Dragon09/odtu_chatbot huggingface dataset:
synergize understanding sporeforming gut bacteria biology to target pathogens

our intestinal microbiota consists of a dense community of microorganisms highly adapted to the human gastrointestinal tract shared species between individuals indicates the presence of evolved and efficient transmission routes that ensure colonisation of beneficial bacterial species research has traditionally focussed on blocking enteric pathogen transmission routes as a means to prevent disease however a greater focus on understanding the transmission routes of commensal gut bacteria is required to promote health spores are resilient structures that maintain bacterial integrity in a dormant state for extended periods my previous work has shown that sporeformation is a prevalent phenotype in the intestinal microbiota that promotes transmission of anaerobic gut bacteria by maintaining viability in adverse aerobic environmental conditions until ingested by a new host however despite its importance sporulation processes in commensal gut bacteria remain poorly understoodsynergize will characterise the metabolic capabilities of gut sporeformers spore composition and the environmental cues involved in spore formation and germination by identifying combinations of bacteria and nutrients that inhibit enteric pathogens synergize also seeks to provide new approaches to target the problem of increasing antimicrobial resistance in european healthcare systems these probiotic isolate and prebiotic nutrient combinations can be used to create synbiotics rationally designed and ingested to decolonise gut pathogens a deeper understanding of sporulation processes could also allow spores to be used to effectively deliver anaerobic probiotic bacteria to the gut by exploring transmission and colonisation processes of intestinal sporeforming bacteria synergize seeks to understand fundamental adaptations of our intestinal microbiota which could provide new tools to target antibiotic resistant pathogens
controlling imperfect robot swarms

robot swarms are incredibly fragile against imperfections worldclass roboticists agree that one of the fundamental challenges in robotics is on the availability of systematic methods with formal guarantees for the design and control of the swarms force multiplication where sensing actuation and communication are distributed in space however no matter the approach control theory or heuristic tiny imperfections are amplified throughout large numbers of robots and rapidly erode and make unpredictable the overall performance of the swarm notwithstanding imperfections can result in surprising complex emergent behaviors such as intricate trajectory patterns of mobile robot swarmsiswarm questions the current paradigm of fighting imperfections to suppress their damaging effects conversely i propose a rigorous control theory to unleash and ally with imperfections such as dropouts delays and scalingbiasing factors in sensors and actuators as novel distributed control inputs for taming emergent behaviors my paradigm shift requires new ways of analyzing algorithms and their robot integration at the crossroads between algebraic graph theory network theory control and mechatronics for multiagent systemsto achieve the projects goal i will 1 develop a general formulation to characterize the controllabilitystabilizability of emergent behaviors with imperfections as inputs 2 introduce unconventional strategies such as the mismatched lyapunov functions to engineer emergent behaviors 3 construct equivalence principles between imperfections and inconsistent shared information to improve the effectiveness of the swarms collective awareness for faultrecovery algorithms and 4 demonstrate the control of a stateoftheart robot swarm in nonlab conditions by exploiting robot imperfectionsiswarm regards imperfections as part of the solution will inspire innovative research methods and lead new applications of multirobot systems
minimal saponinbased adjuvant vaccine platform

adjuplatform seeks to leverage a breakthrough made in the erc2016stg716878 project to validate a synthetic technological platform for the efficient production of optimised saponin adjuvants and improved costeffective vaccines we have recently developed in the laboratory a potent safe stable and streamlined platform based on an optimised version of the vaccine adjuvant qs21 that has led to patent applications and raised the interest of the pharmaceutical industry in this poc project we aim to exploit our synthetic saponin technology to produce scalable adjuvant and vaccine candidates that outperform existing products more costeffectively lowering the risk profile of the commercialisation potential while also achieving valorisation outcomes for market entry the goal is to demonstrate our innovative minimal adjuvant platform in relevant settings for the advancement of novel adjuvant prototypes and molecular vaccines closer to the market the breakthrough innovation potential of adjuplatform lies in the exploitation of this adjuvant vaccine platform for its application with additional formulation systems in a range of disease areas expanding and improving the available vaccine solutions the high purity and excellent chemical control over our synthetic platform compared to the heterogeneous natural product adjuvants as well as its streamlined modular nature and lowcost profile are distinctive attributes of our technology that will be valorised herein making it a potentially superior alternative to existing vaccine models with less structural definition and costlier timelines the main objectives are 1 demonstrate our synthetic technology platform for the streamlined and efficient development of scalable adjuvant and vaccine solutions and 2 implement valorisation opportunities of our platform and products by establishing an optimal ipr strategy and a gotomarket roadmap for the commercialisation
south slavic clitics in language contact contexts

the project investigates the effect of language contact on the structural make up of clitics through the analysis of their use and function in three south slavic contact varieties molise croatian mc burgenland croatian bc and torlak tk although clitics have been extensively examined in standardized slavic languages very little attention has been paid to marginalized andor endangered varieties besides the language preservation and documentation effect the study aims to provide an insight in the layering of complexity in the syntactic structure of clitics by examining their inventories the structural layers truncated in the simplification triggered by contact as well as those interacting with the structures of the other contact variety specifics of the clitic cluster and the presence or absence of clitic doubling and clitic climbing the chosen varieties constitute a minimal triple since 1 mc has had a very extended contact with italian and italoromance varieties having a fairly rich clitic system 2 bc has been in contact with austrian german displaying very scarce cliticization phenomena and 3 tk has been in contact with serbian standard macedonian and bulgarian all with very rich clitic systems empirically the project combines fieldwork in terms of a sociolinguistic questionnaire and elicitation tasks in the three areas with a corpusbased study the latter extends an ongoing study on torlak to further marginalized south slavic varieties in order to provide a wider perspective onto contactrelated issues the data is treated both quantitatively and qualitatively the results of this investigation will therefore not only fill the gap in the empirical description of the use of clitics in understudied varieties and types of contact but they will also provide a contribution to the fundamental questions on the nature of human language
twinning towards scientific and technological excellence in plant protein research

three key global drivers underpin the increased interest in plant proteinbased diets populationgrowth important role of proteins in a healthy diet and the environmental impact of animalbased food chains while an increasing trend in proportion of plant sources included in diet is obvious the current generation of commercial plantbased alternatives is suboptimal more research is needed to obtain a comprehensive understanding on the impact of plant proteins on technological and nutritional functionality including their digestibility and effect on gut microbiota despite high potential of protein crops in türkiye and tübitaks national reputation in plantprotein research this is not sufficient for its scientific recognition among the eus leading institutes therefore tübitak must improve its scientific and technological capacity build a strong international network and fill the gaps of this emerging protein for food field in this context protwin is the most appropriate tool for tübitak to build a capacity development system at national and eu levels and being able to timely capture opportunities in the field of plant proteins research the overall objective of protwin is to stimulate scientific excellence widening and strengthening networking activities between tübitak and topclass leading counterparts in eu in plant protein innovation for food domain by linking it with aarhus university university of liege and cnrispaam the significant complementarities between these institutions processing digestion and gut microbiota for health and omics analytical platforms will enable through networking excellence in research and innovation through knowledge transfer and exchange of best practice protwin will help raise the research profile of tübitak as well as the research profile of its staff the mutual benefits of protwin partnership will secure new joint research projects in the plant protein domain and provide continuity in the future
skinlike twodimensional materialsbased electronics conformable to rough surfaces

the goal of skin2dtronics is to demonstrate the large scale integration lsi transistor count larger than 1000 of soft and thin skinlike electronic devices on ultraflexible substrates capable of conformally adapting to any rough and curved surface this vision will be realized by atomically thin twodimensional materials 2dms that possess compelling properties for this application high electronic performance environmental stability low toxicity and cytoxicity and extreme resilience to mechanical deformations with the increasing pressure towards ubiquitous electronics wearables internetofthings smart patches etc it is urgent to develop electronics that can be easily integrated on the surface of everyday objects and in the case of health monitoring applications on a variety of rough biological surfaces todays conformal electronics is mainly based on conformal sensors with flexible and stretchable electrodes interfaced to bulky silicon chips responsible for processing this approach is prone to mechanical failures especially at the solderings as the connection between the conformal and solid components remains very challenging the research will rely on the complementary conjuncture of four fields sensors 2dbased electronics flexible electronics and biomedical engineering that the pis of the consortium bring each of them recognized experts in their respective fields and with a valuable experience in leading erc projects
a micrornaregulated cell deathinducing gene therapy for tcell acute lymphoblastic leukemia

tcell acute lymphoblastic leukemia tall is an aggressive hematological malignancy although outcome has improved throughout the years with the use of combined chemotherapy the aggressive regimens required for treatment efficacy often lead to significant short and longterm side effects moreover a significant fraction of tall patients relapse which have extremely poor prognosis the current project aligns with the core goal of our erc consolidator grant il7signeture cog648455 to generate new targeted therapies for improved treatment of tall by aiming to develop a gene therapy cell deathinducing system mirto that uses cellendogenous micrornas to regulate the expression of a cell deathinducing gene specifically in tall cells mirtotall while our innovative strategy has the potential to treat tall patients more effectively and safely it also displays market potential that extends well beyond tall this is because our technology is designed so that it can be adapted to the disease of choice or to particular disease subtypes through simple modifications making it ideal for precision medicine in tall other cancers or other indications in which patients may benefit from the targeted delivery of a therapeutic gene our project will build upon the preliminary data that we have already generated and make use of our models and expertise in the molecular and cellular biology of tall to provide preclinical validation of mirtotall laying the ground for a spinoff that will fully explore the mirto technology platform
saving the kashmirian sanskrit heritage

the importance of kashmirian sanskrit literature was realised by scholars only in the late 19thcentury when the literary canon and historiography of sanskrit literature in the indiansubcontinent had already taken shape texts and whole genres that were unique to kashmir aspolitical history were not properly recognised and led to a distorted view of south asianliterature much has changed especially in the last decades but the latest exodus and dissipationof the kashmirian hindu community is bound to have a lasting negative effect on such studies amajor effort to rescue the still unpublished and often unknown highlights of kashmirian sanskritliterature from oblivion is warrantedin the present project a team specialising in editing kashmirian texts will make a larger number ofcarefully selected texts accessible in first editions by utilizing the vast reservoir of manuscriptscans that has sprung up online in recent years previous work on unknown texts from newly openedup archives has suggested that much more is to be discovered one spectacular example would be a17th century piece of visual poetry from kashmir the wishfulfilling tree which is breakingseveral international records for instance for using thirty languages in its intexts but hasremained completely unknown until very recentlythe project will produce a careful selection of previously unknown kashmirian sanskrit works in tenvolumes they will be accompanied by studies of their literary religious or philosophical aspectsfrom which their significance for the history of sanskrit literature can be grasped the project isa bold attempt to drastically improve the basis of scholarship in kashmirian sanskrit and we shallargue that as a result new genres in sanskrit literature need to be defined
customized 21700 cylindrical cells for special applications

univercell holding gmbh established in 2019 in flintbek germany is revolutionizing the battery industry by developing and producing custom battery electrodes and cells tailored for premium applications like scooters ebikes power tools marine applications stationary storage solutions eaviation and sports cars at the heart of our innovation is the dry electrode processing method offering an ecofriendly alternative to the traditional solventbased manufacturing this shift aims to reduce energy consumption by 27 aligning with the european unions environmental goals financially weve charted a clear roadmap were seeking an eic grant of 2387 million coupled with a 15 million investment from eic accelerator we anticipate our initiatives will generate over 100 direct job opportunities thus bolstering the european economy beyond these economic contributions were committed to ensuring our endeavors resonate with the broader societal aspirations of the european union from sustainability to economic resilience as we set our sights on the future our vision is clear to place europe at the forefront of sustainable battery production while emphasizing environmental efficiency strategic partnerships and a commitment to the broader european community
modeling the perturbational gradients of the human brain

studying the brain mechanisms behind consciousness is a major challenge for neuroscience and medicine accumulating evidence shows that the structural histological functional genetic and neurochemical inhomogeneities of the mammalian cortex do not follow a modular distribution instead these properties change following gradients understood as axes of variance along which cortical features are ordered continuously the gradient describing the axis of largest variance principal gradient obtained for an ample range of cortical features follows a unimodaltransmodal organization ranging from externallyoriented sensory and motor regions to multimodal association regions culminating in regions linked with internally oriented higherorder cognitive functions in this project we propose a novel approach constructing validating and exploring wholebrain computational models combining empirical information including anatomical connectivity spatial maps of local neuroanatomical features to reproduce the configuration of human functional gradients as determined using manifold learning techniques applied to functional magnetic resonance imaging fmri data this will allow us to investigate the process by which functional gradients emerge from the spatial distribution of cortical anatomical inhomogeneities the models will also provide the possibility to investigate how different global brain states behave under perturbations in order to achieve our goals we propose a highly interdisciplinary project that combines stateoftheart principal gradient expertise with wholebrain computational modelling proposing a synergy between two groups with large expertise in each area to address a common question do realistic functional gradients emerge from the dynamical equations when coupled by realistic longrange structural connections and modulated locally by empirical maps encoding relevant neurochemical data
mapping the virological consequences of 5500 years of domestication and shifting breeding practices in horses and donkeys

the emergence of animal domestication and farming practices during the last 10000 years is thought to have enhanced humans exposure to infectious diseases but the consequences of these developments for the health of domesticated animals themselves have been largely overlooked understanding the longterm effects of domestication and breeding practices on the epidemiology and evolution of animal pathogens is yet of foremost importance given current concerns regarding modern farming practices and their impact on animal and public health recent major advances in sequencing and biomolecular techniques have allowed the recovery of rare and degraded dna molecules from ancient biological samples including those of pathogens which can persist in the remains of their hosts for millennia here we will leverage a massive collection of ancient equine dna adna libraries spanning more than 50000 years to investigate the past epidemiological and evolutionary dynamics of dna viruses in horses and donkeys from the earliest stages of domestication to modern days an innovative approach will be implemented for the systematic enrichment of viral dna in adna libraries prior to sequencing to maximize viral detection sensitivity metagenomic analyses of resulting datasets will allow characterizing ancient equine viromes and their variations through time ancient viral sequences will be used for genomic and phylodynamic analyses to reconstruct past viral genomic changes geographical spread and transmission dynamics inferred patterns will be interpreted in the light of detailed knowledge about horse and donkeys domestication and management history which has been generated in recent years virodom will provide major insights into the evolutionary history of important equine pathogens which remain understudied and contribute to the development of an integrative one health vision of infectious diseases history and evolution
twaice predictive analytics and digital twin ecosystem to optimise and automate batteries second life and reuse

our solution solves the major cost and safety problems posed by batteries twaices predictive battery analytics platform can be implemented at all stages of the battery value chain optimizing processes such as development operation and reuse second life there is a substantial lack of transparency in liion batteries a problem which can lead to overly high development and operation costs and pose safety risks our software addresses this problem by empowering customers to better understand their batteries they can obtain precise diagnoses and prognoses on battery health and remaining lifetimes using this information to inform their strategic operational decisions underpinned by digital twin technology we combine battery knowledge with artificial intelligence and machine learning to solve the specific customer needs mainly in the energy and mobility sector wherever it is applied our solution will make significant contributions to reducing co2 and ensuring a greener future
healing societies the impact of social context on intergroup reconciliation

the recent increase in intergroup conflicts emphasize the importance of finding ways how to reconcile members of adversary groups subsequently social psychologists have developed evidencebased reconciliation interventions aimed at improving intergroup attitudes and behaviours towards outgroups even though intervention effectiveness and outcomes depend on the context in which people live most empirical research on reconciliation interventions has ignored the impact of the social context the overarching aim of this proposal is to systematically examine the influence of theoretically crucial and preexisting contextual features on effectiveness processes and durability of reconciliation interventions a degree of conflict and perceived threat b degree of integration vs segregation within communities in which people live c ethnic majorities vs minorities and d social norms on outgroup treatment the project consists of four sequential workpackages in wp1 and wp2 i will conduct largescale longitudinal online studies in four european countries affected by conflict these studies will test and compare the effectiveness processes and durability of established wp1 and contextadapted wp2 reconciliation interventions on intergroup attitudes and reallife behaviours of ethnic majorities and minorities living in different social contexts in wp3 and using field experiments most effective and contextadapted reconciliation interventions will be incorporated into participants real life through intergroup contact and multimedia after establishing the impact of the social context in realistic settings and using heterogenous representative samples in wp4 i will develop and empirically evaluate the first theoretical framework for intergroup reconciliation this project will identify effective reconciliation interventions that fit a variety of social contexts and thus provide concrete and effective tools for peacebuilding agents