Dragon09/odtu_chatbot huggingface dataset:
holistic seismic risk assessment of deteriorating offshore wind turbines considering global warming

agingaffected and deteriorating structural elements negatively influence the loadbearing capacity and fragility of offshore wind turbines owts under earthquake and environmental loads increasing ocean temperature and ocean acidification due to climate change exacerbate these impacts highlighting the need for careful consideration for owts against seismic and environmental loads on the other hand the recent installation of owts in seismic active areas eg us and italy and the use of modern larger turbines that are more vulnerable to earthquakes necessitate seismic reliability analysis of deteriorating owts the overall objective of this research is to develop a loss estimation method for owts in a multihazard risk modeling framework by advancing current stateoftheart practices in performancebased earthquake engineering through this postdoctoral fellowship pf my goal is to develop a comprehensive probabilistic framework to assess the fragility and risk of owts exposed to multiple hazards including environmental andor earthquake hazards aging impacts and global warming due to climate change risk and resilience metrics are estimated in terms of financial monetary loss this goal will be achieved through 1 the development of probabilistic models for timedependent corrosion deterioration processes considering global warming 2 environmental wind and wave and seismic hazards estimation 3 owts structural modeling and analysis and development of surrogate models to obtain the structural response and 4 fragility analysis and consequence modeling through estimation of risk metrics
improving clinical trials reporting

this proposal will rigorously evaluate three approaches to reducing research waste and publication bias in clinical trials the findings will provide a firm evidence base to inform efforts to improve the robustness of scientific evidence across the natural and social sciencesnonpublication of results has been estimated to directly waste 85 billion per year in medical research funding gaps left by unreported clinical trial results systematically distort the scientific evidence base because negative findings are especially likely to remain unreported health systems and insurers are often unable to determine how safe effective and costeffective treatments really are leading to costly procurement missteps and suboptimal and sometimes dangerous patient care for example governments worldwide spent over 18 billion on the drug tamiflu before the previously hidden results of several unsuccessful clinical trials emergedtoday research waste safeguards for clinical trials are stronger and more advanced than in any other area of research multiple approaches to tackling the twin problems of research waste and publication bias have been pioneered in the clinical trials space and are now being adopted in other branches of science however it remains unclear which of these measures are effective because their impact has rarely been studied in a systematic and rigorous manner this undermines efforts to improve the robustness of research across the natural and social sciences this proposal will fill an important knowledge gap by providing robust evidence on which approaches to reducing research waste and curbing publication bias are effective breaking new methodological ground it will answer three questionscan stronger funder safeguards reduce research wastecan sending reminder messages to research institutions reduce research wastewhat reminder messages to principal investigators reduce research waste most
cavity quantum electro optics microwave photonics with nonclassical states

optical photons propagate with ultralow loss and do not interact easily which makes them perfect information carriers logical operations and sensing on the other hand rely on nonlinearities and strong interactions ghz clock speed electrical circuits are used for computing and wireless receivers a frequency range where also some of the most promising solidstate quantum devices such as superconducting circuits and semiconductor spin qubits operate and interact the field of microwave photonics combines these two domains of the electromagnetic spectrum with a diverse set of applications ranging from radar and satellite communication to radiooverfiber and remote sensing at the quantum level however no equivalent technology exists this is particularly problematic because quantum systems rely on analog information exchange in a lownoise environment microwave quantum circuits so far are restricted to operate inside an isolated space at millikelvin temperaturesbuilding on our modular electrooptic platform the lowest noise microwaveoptical interconnect to date cqeo will realize a remarkable set of new experiments that were not possible before heralded entanglement and teleportation of longlived qubit states over kilometers of fiber synthesis of optical cat states from microwave cats photonic control and readout of superconducting circuits as well as photonic masing and rf sensing below the standard quantum limit pushing towards higher electrooptic cooperativities will open up the rich physics known from cavity optomechanics except now it is the readily accessible microwave field that experiences dynamical and quantum backaction rather than a mechanical mode this is a new physical limit akin to nonlinear optics that was predicted a decade ago but never realizedcqeo aims to uncover the full range of new physics offered by high quantum cooperativity electrooptics combined with the unique capabilities of circuit quantum electrodynamics
games realising effective and affective transformation societal and cultural domains

games realising effective affective transformation in societal and cultural domainsresearch and innovation in the great project will generate new knowledge of the actual and potential impact of games on european society and new understandings of the innovative uses of games to support the social engagement of citizens leveraging the central role of games in contemporary culture it combines academic studies and practical experimentation with novel applications of games using collaborative design and citizen science methods it brings together researchers with expertise in the areas of games data analytics and policy in an integrated investigation articulated by case studies of the use of games in facilitating dialogue between citizens and policy stakeholders policy makers policy implementers political parties campaigning organisations and affected citizens the context for the research is the climate emergency and each case study is a research cycle addressing a policy issue and research questions with multiple pilots and quantitative and qualitative research activities an important aspect of the method is to place games in an authentic context so that players are aware that their activities have realworld implications and to close the loop by including interactions with policy stakeholders agile methods are applied to adapt games from existing platforms for use as research tools a short games deployed at scale in hit mobile games generating quantitative data and reaching 3 million players and b longer collaborative games based around social dilemmas with small groups generating indepth qualitative data research outcomes include publication of research findings in journal papers a method for using games to rapidly obtain data and insight for policy stakeholders technical resources and guidance for adoption and implementation of the method
metabolic control of immune cell function during fungal infection

the high mortality rates and healthcare costs associated with severe fungal infections highlight the urgent need to unveil their pathogenetic mechanisms and develop more effective diagnosis and treatment measures innate immunity has a key role in host response to fungal infection by mediating fungal recognition and elimination and modulating adaptive immune responses the long pentraxin ptx3 is a soluble pattern recognition receptor that is involved in the recognition and opsonisation of aspergillus fumigatus metabolism is a central regulator of immune cell function phagocytosis of a fumigatus conidia elicits enhanced glycolysis in macrophages and is essential for optimal antifungal effector functions preliminary data from the host lab indicate that ptx3 deficiency by compromising the metabolic reprogramming of macrophages impairs phagocytosis but also their conidiacidal capacity upon infection nevertheless little is known about the mechanistic bases linking the functional activity of ptx3 and immune cell metabolism in the pathogenesis of fungal infection in metafun we propose to i define the molecular and cellular mechanisms whereby ptx3 regulates immune cell metabolism ii dissect the spatiotemporal contribution of ptx3 to intracellular mechanisms of fungal clearance and iii evaluate the contribution of ptx3 to fungicidal mechanisms in a human diseaserelevant context using lungonachip systems this original and interdisciplinary project will reveal previously unanticipated functions of ptx3 in antifungal immunity and will lay the foundations for the identification of new diagnostic and therapeutic targets for fungal disease
hybrid electric propulsion system for regional aircraft

air travel is an important supplement to other means of regional transportation and in some regions the only viable solution however the regional transport market is highly competitive and air travel must demonstrate that it can compete with hispeed trains cars or coaches one major issue is the perception of the high co2 and greenhouse gas ghg emissions by planes for these short journeys hybridization of the propulsion system enables combining the technical components benefits thereby achieving an overall efficiency improvement it is a concept well understood by the general public due to the hybridization of automobiles and can bring a real impact on the reduction of ghg emissionswhile enabling rather than limiting new sources of energy in aviation an ambitious path to reduction of greenhouse gases and the pathway to a cleaner and greener aviation for regional flights is built upon three pillarselectric hybridizationan ultraefficient turboprop thermal engine100 saf compatibilityheart will be a first step on the path to hybridization of regional aircraft and a reduction of up to xx of ghg this will be accomplished by achieving a strategic global objective of demonstrating within 36 months the viability of a hybrid electric thermal turboprop etp within the scope of a dedicated integrated ground test demonstratorheart will build on existing state of the art integrating the following technologies into the demonstratorcore thermal engineelectric motor and power electronicsgearboxpropellernacelle and heat exchangerthis will be executed in conjunction with the toplevel aircraft requirements that will be defined in parallel clean aviation research projects to ensure that these requirements are met in full heart brings together the leading engine manufacturers rolls royce and safran with leading airframers atr airbus and leonardo along with key manufacturers and research organisations
reinforce sciencepolicy interfaces in innovative ways to boost effectiveness and interconnectedness of biodiversity and climate policies

in order to inform global action on biodiversity and climate protection ipbes ipcc and corresponding national processes were created to improve the sciencepolicy interface spi between knowledge holders and decision makers nevertheless there are large differences in the capacities and experiences among countries in supporting and engaging in ipbes and ipcc processes in addition the knowledge systems on climate and biodiversity remain fragmented despite thematic and procedural overlaps in both domainsthe aim of this project is to systematically evaluate and process existing experiences to provide other countries and stakeholders guidance and inspiration for spi development respin will assess existing potentials and barriers to foster spi processes around biodiversity and climate change to provide an improved access to information for decisions at eu national and subnational levels this project will 1 empower knowledge holders to enhance the representation across regions knowledge systems and stakeholder groups in spi processes considering the interlinkages between biodiversity and climate 2 empower decision makers at different levels across the globe to uptake the knowledge and capacity building provided by ipbes and ipcc 3 develop future perspectives for spi engagement at eu level enhancing eu capacities to incorporate ipbes and ipcc functions in their knowledge procedures and funding provisions and 4 develop and disseminate online capacity building programs to upscale best practices and translate relevant project outputs for key stakeholders and decisionmakers across the globein sum respin will develop new spi formats for integrated ipbes and ipcc processes provide training and digital guidelines and develop action agendas with strategic partners to ensure integrated spi processes on global national and subnational levels
next generation of thermalelectrical devices for heat and power management

thermocool addresses critical global challenges energy transition and digitalization with 20 of global energy used for cooling and 16 billion ac units in use energyefficient alternatives are vital thermoelectric coolers te offer a solution saving 1795 kwhy and reducing co2 emissions by 38 per person compared to standard acadditionally te has applications in highpower computing and batteries where conventional cooling falls short the project leverages novel thermoelectric materials to drive advancementsin parallelthermocool contributes to digitalization the internet of everything ioe necessitates trillions of connected devices to power them sustainably thermal energy harvesters are explored tapping into heat sources like the human body buildings and the sun this approach reduces maintenance costs and indirectly cuts co2 emissions by optimizing information flowsthermocool focuses on three key objectives1enhancing the efficiency of energy conversion devices including thermoelectric generators and pyroelectric generators for electricity generation and thermoelectric coolers and electrocaloric coolers for cooling2prioritizing lowcost sustainable materials with minimal reliance on critical raw materials and emphasizing recyclability3demonstrating the effectiveness of these technologies in challenging environments where conventional systems are less efficientcollaborative research will elevate these technologies from trl3 to trl5 involving researchers with complementary expertise in thermoelectric and ferroelectric materialsthese solidstate devices share key advantages zero maintenance costs compactness lightweight silence and environmental friendliness they have the potential to revolutionize energy conversion and cooling addressing pressing global challengesthermocool offers efficient lowcost and ecofriendly solutions that will benefit society the environment and the economy heralding a promising future
hybrid cooling management for it infrastructures

the purpose of hycoolit is to develop a set of processes supported by both digital and technical equipment innovative solutions for an efficient and reliable development of it server rooms for advanced tertiary buildings with a special focus on its replicability through standardisation in parallel a highly innovative rackintegrated adsorption chiller for wasteheat powered server cooling is developed and optimized to carry out efficient liquid cooling of it servers and simultaneously provide cooling to the server room itself in a compact selfcontained and costeffective way the building digital twin environment bdte will be developed as a paas with their specific web api communication microservices to connect specific tools to support planning and design assessment commissioning and performance evaluation processes including advanced technical equipment solutions digitalized through as bdt simbots interactive simulators in the ict ecosystem to enable a more effective integration and operation of these advanced server rooms within the whole buildings moreover simbots pave the way for the future prescription of the innovative technical equipment proposed in the project in addition existing rooms can be mirrored and enhanced with the usage of bdt environments to generate improved baselines and forecasting to support designers in the design phase choosing the best design option and for maintenance engineers to enable performance contracting to realise the kpis all methodology and software solutions will be tested and validated in one of the polimi campus building undergoing renovation of campus server room as a representative trl 5 living lab whereas the innovative rackintegrated adsorption chiller for wasteheat powered server cooling will be tested in a dedicated calorimetric laboratory as trl 4 testing environment
tumor microenvironment normalization for enhanced photodynamic therapy

the progression of cancer is closely associated with alterations in the mechanocellular phenotype and in the structure and mechanical properties of the tumor microenvironment tme in a complex and not wellunderstood manner desmoplasia a tumourassociated fibrotic reaction is responsible for tumor stiffening poses a major barrier to effective drug delivery although novel therapeutic strategies that target cancer cells are emerging their efficacy varies due to intra and interpatient variability as well as tumor heterogeneity notably photodynamic therapy pdt is gaining prominence as a compelling alternative this twostage treatment harnesses both light energy and a specialized drug photosensitizer ps to target cancer cells upon activation by a specific wavelength of light however the effectiveness of pdt is greatly compromised by various resistance factors originating from the complex tme these factors can present several biological barriers including desmoplasia in this project we propose the use of tme normalization treatment with approved antifibrotic drugs in combination with pdt we aim to test the hypothesis that the combination of antifibrotic drugs that remodel and normalize the tme with pdt can increase the pdt efficiency the specific research objectives are focused on breast cancer bc and includes in vitro study of the effect of different components of pdt treatment on bc cells in vivo study of the effectiveness of the combination of pdt with antifibrotic treatment in murine bc models and mathematic modelling to optimize the combination therapies in the proposed project the fellow will acquire scientific and complementary skills according to his personalized career development plan and through advanced training international and intersectoral mobility will reach a position of professional maturity in research
early treatment of atrial fibrillation for stroke prevention trial in acute stroke

patients with acute ischemic stroke and atrial fibrillation are at high risk for recurrent stroke and other adverse cardiovascular complications usual care comprises oral anticoagulation and rate control however it is unclear whether existing interventions for early rhythm control reduce the risk of adverse cardiovascular outcomes in these vulnerable patients eaststroke early treatment of atrial fibrillation for stroke prevention trial in acute stroke is set out to tackle and reduce the individual and societal burden of death and disability by providing evidence for effective secondary prevention using readily available interventions in these patients to this end eaststroke is an investigatorinitiated prospective randomized open blinded endpoint assessment probe multi trial to test whether early rhythm control therapy prevents adverse cardiovascular outcome in patients with acute ischemic stroke and atrial fibrillation compared to usual care up to 1746 patients will be enrolled trial organisation relies on a network of experienced clinical researchers patient representatives and health economics experts outcome evaluation will involve a comprehensive array of clinical and safety parameters health and socioeconomic outcomes including patient reported outcome measures we will also perform costeffectiveness analyses to address the needs of payers and ease implementation into reimbursement schemes the project addresses a major health burden and will provide evidence for more effective prevention of adverse outcomes in an area of high public health need we expect that the results of eaststroke will be implemented rapidly throughout europe will support health equity and will prevent more than 150 thousand recurrent strokes or adverse cardiovascular outcomes over a period of five years by this eaststroke will lead to significant costsavings to european health systems and societies
the gentrification of activism autonomous collective politics and the right to the city in exarchia athens

gapria aims to examine the gentrification of activism which entails the ways radical activist neighbourhoods become gentrified leading to the eviction of emancipatory visions about city life although gentrification and eviction studies have thoroughly documented the social and material costs of gentrification policies on the urban poor they have failed to document their political costs relating to the eviction of communities of activists that produce more emancipatory visions about city life gapria will fill this gap by examining such questions in the urban neighbourhood of exarchia in athens greece that has a long history of antiauthoritarian and direct democratic struggles gapria will examine the gentrification of activism along 4 levels of enquiry 1 the conceptual level whereby activists produce emancipatory ideas about city life 2 the discursive level whereby gapria will aim to substantiate the emerging concept of evictability by exploring through policy and media analysis how certain subjects are produced as evictable 3 the level of praxis whereby through ethnographic fieldwork with activists and residents resistance to gentrification will be documented 4 the comparative level whereby the gentrification of activism will be explored in an interdisciplinary manner through the organization of an international conference engaging scholars from anthropology urban studies politics and human geography gapria will deliver a monograph a special issue and a peerreviewed journal article actions for networking and knowledge transfer include a website a policy brief a community event a short film the organization of an international conference and a proposal for a european research council starting grant results will contribute directly to transnational debates on the costs of urban regeneration policies their interconnection with recent attacks on autonomous activism and the worldwide rise of the far right