Dragon09/odtu_chatbot huggingface dataset:
tuneable conditional control of engineered bacterial therapeutics

engineered microbes are attractive platforms for the diagnosis and treatment of several diseases for example bacteria can selectively target tumors and are ideal vehicles for in situ delivery of therapeutic agentshowever as of today no engineered living bacterial therapeutics in clinical trials have the ability for conditional control of therapeutic activity this lack of reliable control over the timing and dosage of effector molecule production limits the specificity safety and efficacy of current bacterial therapiesin this project i will use of a generalizable synthetic receptor platform to control the in vivo therapeutic activity of engineered bacteria using an externally administered molecules as a proof of concept i will use a receptor responding to a molecule found in the diet to control therapeutic release in tumors i will use a safe probiotic e coli nissle 1917 with demonstrated tumor targeting propertiesin a first research line i will characterize the doseresponse and kinetics of synthetic receptors implemented in bacteria colonizing an in vitro 3d tumor spheroids model i will then evaluate the therapeutic activity of strains producing cytolytic molecules in response to external inducerin a second research line i will characterize conditional control of gene expression and then therapeutic release in tumor mice model using cytolytic and immunotherapeutic effectorsmy work will deliver robust safe and efficient frameworks for conditional control of bacterial cancer therapy by enabling in situ drug delivery with a highlyprecise dosage and timing it will allow physicians and ultimately the patients to finely control bacterial therapeutic activitybecause of its modularity my platform will be further engineerable to detect other conditional inducers this system will be reusable for the treatment of many other pathologies including autoimmune and infectious diseases
decoupling it a global comparative ethnography of the role of it in the mitigation of the climate crisis

climate change is one of the biggest existential issues of our time and there is little global agreement on how to deal with it governments and private sector industries argue that decoupling economic growth from carbon emissions is the best way to reduce climate impact while still maintaining a healthy economy yet how to do so remains an unsolved question most proponents of decoupling see it as playing a central role whereas critics argue that it itself is entangled with incessant capitalist growth and has a large and often unacknowledged climate impact in addition it solutions frequently have the sideeffect of creating new and unforeseen problems social or climatic the challenge of decoupling is thus broader than the management of the relationship between the economy and the climate as much as decoupling is about how we imagine the climate crisis can be solved with technologies trusting that they can create the changes we need it is also about the cultural value of lifestyles that we do not want to change the decouplingit project thus approaches decoupling as a matter of how sociocultural change is generated in the spaces between it climate change and capitalism we study these spaces through ethnographic explorations of how it professionals and enterprises articulate climate change as a problem in demand of itgenerated change and in particular how they practically deploy it with the climate in mind while both climate change and it are manifested in globally diverse ways their interrelationship must be studied comparatively with attention to how particular conditions in different locations give rise to disparate responses consequently we conduct research in distinct but conceptually connected climateithubs each facing climate change in their own ways this addresses a major theoretical gap in qualitative social science research namely how global change is driven through the intersecting roles of it climate change and capitalism
health investments in central and eastern europe

to address the low startup survival rate and the lack of funding in modest and moderate innovation ecosystems within europe namely in central and eastern european countries the consortium led by eit health in collaboration with innostars civitta and other entities as well as an advisory board including the eif will use their individual expertise to implement activities that build critical mass on both the investor and venturebuilding frontgiven the investment challenges in earlystage ventures the project will seek to collaborate with local startup support organizations to provide capacity building initiatives as well as to derisk local innovators to set the foundations for modest and moderate regions to become sustainable and competitive with more dynamic regions within the european ecosystemthe project will be structured around the impact pathway methodology scoping engaging and implementing the specific objectives are 1 to build robust and sustainable earlystage investment ecosystems and increase critical mass 2 to increase venture investments through a cultivating life sciences local investment and b attracting foreign investors into the local innovation ecosystem 3 to provide derisking and investment readiness support for dealflow exchange to increase syndication and 4 to disseminate and implement project outcomes create european foundation to address fragmentation in eu market and support crossborder investmentsin addition to said objectives as well as the expected outcomes set out in the call the project will aim to impact wider european goals including furthering the european innovation agenda increasing investment competitiveness startup as wells as job creation knowledge transfer and widening european outreach furthermore project results are expected to be applicable to other regions and nonhealth related industries and scope a paneuropean funding initiative for health tech ventures rich in assets
the electrophysiological landscape of dreams

why and how do we dream although this question has fascinated humankind since the earliest ages it remains largely unanswered each night when we fall asleep we progressively disengage from the external world until we cease to perceive it and to act upon it despite this sensorimotor disconnection in our dreams we perceive and act and although we do so in a purely imaginary world our experiences bear so much resemblance with the real world that we almost invariably take them for real how does the brain create such a realworld analogue and why based on my previous work in which i identified a neural signature of dreaming i propose to answer this question by studying a set of electroencephalographic eeg potentials which not only occur spontaneously during sleep but in a similar form also during wakefulness as part of reactions to unexpected environmental stimuli the overarching objective of this proposal is to understand the precise role of these brain potentials in the generation of dreams specifically i will 1 provide a systematic characterization of these potentials in the sleeping and waking brain 2 clarify their relation to arousal systems 3 assess how they relate to sensory and motor features of dreams and 4 manipulate them to causally affect dreams to achieve these aims i will employ a unique combination of cuttingedge experimental approaches including 256channelhighdensity eeg sleep recordings combined with controlled sensory stimulations serial awakening paradigms pharmacological manipulations closedloop acoustic slow wave modulation and movement analyses in neurological patients who act out their dreams these projects will contribute to the basic understanding of how and why we dream with implications for the fields of consciousness neuroscience and neuropsychiatry they will also provide technological and pharmacological tools to manipulate sleep and dreams with clinical relevance for patients with sleep disorders
developing the worlds first quantum modem

we are in the midst of a quantum revolution quantum computers will bring unprecedented capabilities to scientists and engineers quantum communication networks now stretch for kilometres enabling unhackable communication protocols remarkably these technologies have evolved independently from one another quantum technologists are well aware of the immense potential of bringing communication and computing together however they have been unable to overcome a critical technical challenge quantum computers and quantum channels operate at vastly different frequency regimes we have solved this challenge our quantum modem is the first device in the world to implement highfidelity quantum transduction and bridge the 100000x frequency gap between the ghzfrequency typical of quantum processors and the thz telecom range with our modems quantum information is no longer confined to cryostats and can be routed via optical fibres across vast distances at room temperature
semanticaware intelligent localization and sensing towards 6g

the rise of applications like smart cities and augmented reality has emphasized the critical importance of precise lowlatency localization and sensing ls in the context of 6g communications meeting ls demands involves inundating transceivers with extensive data from sources like pilot signals and sensors creating redundancy that overwhelms communication networks addressing this redundancy is a key aspect of semantic communications aiming to enhance energy efficiency and support 6g technology semantic communications prioritize transmitting useful information over mere data transmission sails6gs goal is to improve the energy efficiency of ls without compromising utility by leveraging the principles of semantic communications historically ls optimization has focused on primary kpis such as accuracy neglecting energy efficiency sails6g bridges this gap by integrating energy efficiency into ls optimization through three wps wp1 addresses energyconstrained optimization issues using optimization theory tools wp2 tackles complex nonlinear optimization challenges from wp1 employing learning structures wp3 extends energyefficient ls algorithms from wp1 and wp2 considering distributed processing and privacy constraints the applicants expertise in information theory optimization theory and privacypreserving learning along with the supervisors localization knowledge supports these wps the outcome is optimized transceivers reducing energy consumption while meeting ls requirements their performance is evaluated against traditional methods and theoretical bounds the ultimate aim is to introduce a groundbreaking framework for semantic ls widely accepted in the scientific community marking a significant field advancement building this framework boosts the applicants scientific impact and strengthens his managerial educational and research skills facilitated by the supervisors network advancing his journey towards a professorship
straintronic control of correlations in twisted van der waals heterostructures

correlations and topology are the cornerstones of modern condensed matter physics and their coexistence is believed to lead to novel quantum electronic devices with builtin information protection in the landmark discoveries of previous years it has been found that in 2d materials placed on top of each other at a magic rotation angle correlated phases appear in contrast to hightc materials in twisted van der waals materials correlation effects are coupled with topology and thanks to their gate tuneability the exploration of their phase diagram takes only days instead of years this has led to the discovery of a multitude of correlated phases including correlated insulators orbital magnetic nonconventional superconducting and ferroelectric phases etc despite the immense interest the understanding of their behaviour at the microscopic level is limited which calls for further experiments and novel experimental toolsin this project we will implement techniques that are radically new in this field hydrostatic pressure and mechanical strain to uncover the ground state properties of twisted graphene and transition metal dichalcogenide heterostructures since the interlayer coupling plays the dominant role changing the distance of the layers with hydrostatic pressure has a dramatic effect on the band structure and the correlated phases that emerge the symmetries of the system can be deterministically broken by strain patterns applied insitu this very timely project will lead to several breakthroughs including a revealing the ground state of twisted bilayer graphene at different filling factors from the large set of competing phases b insitu engineering of the topology of these systems or c tuning quantum phase transition between nonfermi liquid phases the highly challenging research concept relies on my unique background in sample fabrication quantum transport under strain and pressure and studies on correlated and topological systems
critical infrastructure high accuracy and robustness increase integrated synchronization solutions

critical infrastructure such as telecommunications networks requires gnss based time reference to enable their proper functioning over a large areaespecially emerging telecommunications applications such as 5g or time division duplex require a highly accurate and secure timing distribution failure of the time distribution service can lead to failure of critical infrastructure resulting in blackouts or failure of the telecommunications network with damages exceeding the billion for whole economies as well as severe safety and security risks for the general publicfrom the very nature of the gnss systems they are vulnerable to external independent and arbitrary radio interferences jamming and spoofing consequently the time synchronization may be interrupted or falsified causing the real danger of time reference outage or alteration of the telecom network time reference therefore finding approaches for detecting and mitigating radio interferences jamming and spoofing attacks is a critical issue for the security of telecom networksmoreover critical infrastructure requires safety layers ensuring protection and integrity in the communication between nodes and terminals in the network eg time synchronisation at the base stations of the telecommunications networks the emerging technology of blockchainbased verification identification and coding has been proven multiple times to be the future of information exchange applications in the presented initiative the critical infrastructure high accuracy and robustness increase integrated synchronization solutions chriss will demonstrate first on the market an integrated into one device galileo based timing distribution and synchronization solution enabling increased resilience to gnss signals interference jamming spoofing and cyberattack on fiberoptics distribution layer resulting in increased time distribution service availability accuracy and reliability
revealing the gene regulatory networks that govern cell mechanical properties by single cell microfluidics

changes in mechanical properties of cells are key in a range of processes including cell migration and development and are frequently altered in disease states such as cancers yet despite their key role the gene regulatory networks underlying these processes are currently largely unresolved thus the central aim of my proposed project is to gain a detailed understanding of how cellular mechanical properties are controlled by developing microfluidic technology to simultaneously measure the mechanical phenotype and transcriptome of single cells in high throughput the advent of single cell sequencing methods has been transformational for our understanding of biology and multimodal approaches such as those combining genome and transcriptome measurements of the same cell are likely to be even more so the physical dimension however remains largely unexplored and its exploitation offers the prospect of revealing how the biochemical composition of cells relates to their physical properties i will thus apply my phd experience to develop a microfluidic platform that combines physical and biochemical cell analysis using realtime deformability cytometry and dropletbased single cell rna sequencing by matching the transcriptomic profile of each cell with its brightfield image which yields their mechanical and morphological features i will identify genes involved in the regulation of mechanical properties and their generality across cell types in addition to elucidating fundamental regulators of cell mechanics this technology will allow the investigation of their interplay with gene expression during both physiological and pathological cell state changes
deciphering the effect of vegetation and erosion on basalt and carbonate weathering by novel denudation rate approaches

the chemical weathering of rocks on the earths surface draws down atmospheric co2 balancing emissions from volcanoes and maintaining habitable temperatures basalt and carbonate rocks are particularly crucial in this balance because they are efficiently weathered as estimated from studies of the dissolved elements in rivers basalt accounts for 2035 of modern global silicate weathering and co2 consumption flux despite only covering 5 of earths surface to formulate sensitivities and feedbacks between weathering of these rocks and climate we need an accurate description of the exact processes that drive the conversion of rock to soil by weathering besides water flow erosion rate and vegetation are thought to exercise significant control currently however we lack the tools needed to decipher these controls because the preferred approach used to quantify erosion and weathering rates cosmogenic nuclides produced in situ in quartz does not work in basalt and carbonate lithologies the aim of devendra dedicated to the pioneer of cosmogenic nuclide geochemistry devendra lal 1920 2012 is to eliminate this blind spot using a novel method never applied to basalt and carbonate lithologies the ratio of cosmogenic beryllium10 rained out from the atmosphere to stable beryllium9 released by weathering devendra will develop this system as a novel erosion and weathering rate meter for these rocks and will use this new method to calibrate using globallydistributed soil profiles and catchments of differing climate and erosion rate the laws that govern weathering and co2 drawdown in these rocks the outcomes from devendra will refine the global weathering models that are used to understand earths carbon cycle on geological time scales to predict the trajectory of anthropogenic co2 in coming centuries and to estimate the potential for negative co2 emissions by artificiallyenhanced weathering of basalts
tales of the diasporic ordinary aesthetics affects archives

migration is almost always framed as the result of exceptional circumstances as in the 2015 refugee crisis for instance this impacts the reception of narratives produced by those living in the diaspora works by black and ethnic minority artists are overwhelmingly associated with labels that set them apart from the unmarked norm these frameworks favour generational models such as the windrush generation in britain socalled guest worker literature in germany and ethnic and area studies designations in the us such formulas reinforce an understanding of migration as perpetually new by turning to what we call tales of the diasporic ordinary this project asks what happens if we instead apply a normalising perspective to the study of contemporary diasporic art extending pi haschemi yekanis pathbreaking work on entangled tonalities in the rise of the british novel todo mobilises three conceptual terms aesthetics affects and archives this firstly disrupts models of national canon formation and considers queer diasporic artistic practice and aesthetics as entangled with postworld war ii global histories of the decline of empire neoimperialism and the more recent rise of the new right secondly drawing on innovative methods from autotheory and queer diasporic critique todo stipulates that ordinary diasporic texts promote an affective bearing that exceeds the binary of romanticising the homeland of once and neoliberal ideals of assimilation and integration thirdly the analysed texts complicate official historiographies and contribute to an archive of the lived experiences of migrants and their children across generations exposing the continuity of racism artistic practice can acknowledge negative affects and contribute to a reimagination of community that goes beyond national and heteronormative constraints thus the project underlines the relevance of tales of the diasporic ordinary to challenge racism and foster new modes of belonging
scalable grapheneenabled electrochemical treatment for complete destruction of forever chemicals in contaminated water

poly and perfluoroalkyl substances pfas have been used since the 1940s and are known as forever chemicals due to their extreme persistency to advanced wastewater treatment strategies due to the strength of the cf bond each released molecule of pfas remains in the environment today there are more than 9000 known pfas majority of them being extremely resistant to any kind of degradation and with high bioaccumulation potentials and toxicities electrochemical processes can address the challenge of pfas presence in water provided that the anode material is low cost and can break the cf bond without forming toxic byproducts graphene sponge anode developed by our team is the first material to fulfill both requirements in this project we will aim at upscaling the electrochemical treatment based on graphene sponge electrodes and testing its longterm performance in degrading pfas from complex residual streams this will enable us to answer key scientific and technical questions required for further technology adoption by the water industry many of them related to the fundamental mechanisms of electrochemical cf bond breakage and features of anodically polarized graphene based on the results achieved to date at labscale graphec technology has a strong potential to evolve into a sustainable chemicalfree destruction technology for pfasladen wastewaters and achieve their complete destruction at ambient temperature and pressure in modular units with low capital and operational costfinally this project also aims at keeping the existing intellectual property and engaging early technology adopters in europe and beyond to form a mature network of future clients and reach a technology readiness level trl 6 at the end of the project the project will deliver a new platform technology for the removal of toxic and persistent chemicals from water and is likely to play a key role in the eus green deal agenda for securing a toxicfree environment