Dragon09/odtu_chatbot huggingface dataset:
pfas exposure relationship to serum lipids in children and adults mechanism of action and potential treatment of high exposed individuals

perfluoroalkyl substances pfas are widely used persist in the environment and are present in all human populations many hotspot areas across europe in which humans are exposed through contaminated water or food has raised public concern due to the possible adverse health effects of pfas the overarching aim of my proposal is to determine if pfas exposure is causally linked to increased serum cholesterol and liver enzymes and if pfas elimination can be enhanced pilot findings from our first ever randomized crossover trial suggest that administration of the bile acid sequestrant cholestyramine significantly reduces serum pfas in 34 high exposed individuals probably by reducing intestinal reabsorption in work package 1 wp1 i will explore the promising pilot findings in a rigorously conducted randomized crossover trial a trial administering the food supplement psyllium which also reduces bile reabsorption will be undertaken pfas exposure has been associated with increased serum cholesterol and liver enzymes which pose a major impact to human health due to the causal link to cardiovascular diseases cvd it remains unclear whether the associations are causal and mechanisms by which pfas affect lipid metabolism are not established in wp23 i will study the causal relationships between child and adult pfas exposure and serum lipids and liver enzymes in high quality prospective cohorts using a novel statistical approach target trial emulation to establish causal effects in observational data in wp4 the mechanisms by which pfas affect lipid metabolism in human liver cells will be investigated overview see figure 2 the project will break new grounds for our understanding of the mechanism of action of pfas on lipid metabolism and the relation with serum cholesterol and liver enzymes as well as whether pfas elimination can be enhanced which will guide authorities in the handling and advise of hotspots and regulation of pfas to reduce future cvd
unleashing gaze neurocognitive processes underlying gaze control and perception across freeviewing eye movements

we constantly move our eyes to explore our surroundings in between short periods of fixation saccades cause drastic changes to the visual input yet we experience a continuous and stable world from the incessant flow of snapshots while the perceptual consequences of saccadic eye movements are manifold experiments to study them are surprisingly similar and lean towards a paradoxically passive investigation of active visual perception instead of isolated stereotyped eye movements directed by artificial cues everyday gaze is dynamically driven by scene statistics and internal goals to genuinely understand active perception across eye movements we need to study it under natural but still precisely controlled conditions which so far has been hindered by methodological limitations the transient nature of perisaccadic phenomena requires realtime knowledge of the upcoming saccade to tailor the perceptual measurement to its predicted spatial and temporal dynamicsfortunately freeviewing saccades are not random but guided by salient and relevant scene features my team and i will introduce a methodology that evaluates these factors online to predict saccades during free exploration on dynamic visual noise to study active perception through gazecontingent measures across unconstrained viewing my approach integrates highprecision yet rigid techniques from classic vision science with more flexible but coarser methods of scene viewing research where subtle perisaccadic processes are traditionally not consideredcombining stateoftheart psychophysical computational and neuroscientific expertise freeview will pioneer our understanding of actually active perception and gaze control assess the validity of inferences drawn from atypical instructed saccades and introduce a versatile tool for testing populations that may struggle to learn or adhere to stringent instructions such as children the elderly patients or nonhuman primates
retrofitting of fishing fleets with low payback time and easy to deploy solutions for footprint and ghg emissions reduction

refest is focused on the most promising scalable technologies with low capex easy to deploy and suitable to be installed in a broad range of traditional fishing ships to provide hydrodynamics electrical power management alternative propellers solar electricity generation and propulsion batteries sensoring and digitalization hull appendages and air lubrication refest aims to achieve trl6 procedures and technologies to secure the reduction of fuel consumption and ghg emissions up to 40 reduction compared to the original design the solutions proposed will be designed to ready to deploy in a broad range of small fishing vessels and they are characterized by a low capex and opex requirements to significantly reduce the payback time ensuring upscaling of the proposed solutions after project implementation till 2029 the main innovations are summarized as follow i innovative design by the use bulbs and spray rails that allow to improve hull hydrodynamics to minimize the water friction and reduce external and underwater noise iirecyclable thermoplastic composites for maritime applications iii air lubrication systems iv integration of multifunctional optical fibre sensors for hull fishing ships monitoring v propulsion systems based on rim drive solutions and its hybridization with current diesel engines vi battery pack optimized to be used under cold weathers and with high percentage of reusablerecyclable components vii bms ems and pms to maximize the energy consumption in the vessel viii cloudbased ecodriving software and ix lowweight and flexible silicon pv panels viii three retrofit demo traditional fishing ships in north sea denmark norway and baltic sea lithuania
a trustworthy speechbased ai monitoring system for the prediction of relapse in individuals with schizophrenia

schizophrenia affects a staggering 21 million people worldwide with 80 of these citizens suffering from a relapsing disease putting their health and safety at enormous risk timely detection of these psychotic relapses would require very frequent contact with clinicians which is neither desirable nor feasible an accurate online relapse predictor could alert clinicians of subtle deterioration which enables timely intervention and allow safe discontinuation of longterm medication which so many affected citizens desire our consortium demonstrated that subtle alterations in speech carry a predictive signal for psychosis onset this project will develop an ai monitoring system that leverages spoken language processing slp and natural language processing nlp of speech recorded at home to calculate the relapse risk the monitoring tool we develop will be validated retrospectively in a longitudinal cohort crosssectionally across six languages after which it will be tested prospectively in a multicenter randomized trial with the end goal of improving functional and clinical outcomes of those affected by schizophrenia developing such a system for exceptionally vulnerable people requires buyin from clinicians and mental health care service users namely trust a lack of trust is the biggest obstacle to the realworld implementation of a speechbased monitoring system trusting will develop a framework that systematically ensures addressing all the criteria for trustworthy ai put forward by the eu this will ensure an empirically based and validated tool that can reliably detect pending relapse as the core philosophy of trustworthiness is part of every aspect of the project it will be a system more likely to be welcomed and embraced by service users and their carers trusting generates the scientific and social foundation for disruptive technology to deliver the unmet promise of an equitable and just form of healthcare for people at risk of relapse
accelerated precision tests of lepton universality

the standard model sm of particle physics describes most fundamental phenomena extraordinarily well but unresolved questions such as the matterantimatter asymmetry remain new physics np able to resolve these questions has not been found in direct searches yet so it must be either extremely rare or manifest at higher energies that can only be probed by precision sm measurementslepton flavor universality lfu is one of the most precise predictions of the sm but discrepancies with measurements have emerged in decays of b hadrons unambiguously establishing the presence of lfu breaking effects is therefore one of the most vital and timely challenges in hep however the current experimental precision is not sufficient for a discovery due to the limited size of data sets therefore the lhcb experiment at cern is being upgraded to measure b hadrons at higher rates but at these rates efficient selection of signals requires exceptional computing demands cpubased systems no longer meet these demands so realtime selection constitutes a major bottleneck the allen system that i have pioneered and led from proofofconcept to the new lhcb baseline implementation solves this by using graphics processing units and even provides a large headroom in computing resourceswith alpaca i will build a team to demonstrate that the experimental precision of lfu observables required to establish the presence of np is reached by using accelerated realtime analysis systems we will 1 enhance allen using the extra computing resources to increase the data samples for lfu observables by a factor two 2 test lfu in ratios of branching fractions of b c l nu transitions with electrons for the first time at lhcb 3 characterize np by measuring angular observables of b c tau nu transitions at lhcb4 direct the design of future experiments and facilities by unlocking new computing potential
14 angstroms module integration

the 14ami project is about creating technological solutions for the 14 angstrom cmos technology node including a fully integrated functional cfet complementary field effect transistor as new active cmos device and stateoftheart holistic metrology techniques for both wafer and mask inspection and review all is aimed to keep the pace in the industry to follow moores law the project addresses the following 3 main pillars that are relevant in enabling manufacture of 14a technology 1 lithography 2 metrology and 3 process module integrationin lithography the aim is to realize solutions for the 055na euv scanner platform to secure 14angstrom node compliance in performance that is resolution alignment throughput and optics lifetime in metrology the objective is to cover wafer and mask metrology and quality control the aim is to develop holistic metrology tools methods and data analytics to improve overlay cd and focus measurement and quality control with a precision to tolerance pt ratio between 01 and 03 in process module integration work covers the realization and demonstration of a cfet complementary field effect transistor cmos device three options will be investigated for integration a monolithic sequential and a hybrid solution in addition the partners will develop a pfasfree photo resist to reduce the ecological footprint of photolithography processes and a smart ai based sensor technology to improve vacuum chambers efficiency and reduce waste at societal level the expected impact of the 14ami project will support the partners and their supplier network to stay at the leading edge of hightech developments crucial to meet the digitization challenges of the european society moreover 14ami will boost industrial competitiveness and attract talent in europe while enabling new application in areas such as security communication and enabling of further automation in mobility health and research
longterm microphysiological sample imaging for evaluation of polypharmacy in liver

delivery aims to build a radically new technology for personalized health care which provides for the first time the possibility to investigate polypharmacy on individual patients polypharmacy is the effect that the many combinations and permutations of drug mixtures which are typically prescribed to the chronically sick or the elderly population eg painkillers beta blockers blood thinners antidepressants and statins have on the human body polypharmacy is becoming a major issue in the ageing population as well over 10 of hospital admissions for people over 60 years of age are due to currently unknown interactions of the multiple drugs being prescribed by the specialized physicians and general practitioners routinely visited by the elderly currently no single platform exists that can be utilized in a highly parallelized fashion to monitor such effects at the cellular and tissue level delivery will provide an integrated microphysiological system mps culture and microscopic imaging platform specifically for the purpose of maintaining treating and longterm imaging of patientspecific cells within their microenvironment this mps platform will allow physicians biomedical scientists and researchers to determine the individual response of human tissue biopsies to a combination of multiple drugs delivery will enable individualized treatment options providing essential tools towards a better quality of life for older people by allowing improved personalized healthcare novel medicines with the potential to reverse the effects of ageing and nonalcoholic fatty liver disease nafld will be tested within typical polypharmacy contexts to determine possible interactions and the delivery mps system will be the purposebuilt platform to provide this service such a system also requires a paradigm shift in microscopy away from the single bulky instrument providing one imaging modality towards compact and modular yet still highend devices
systematically dissecting the regulatory logic of chromatin modifications

chromatin modifications are a key mechanism for regulating gene expression patterns in normal and disease settings nonetheless despite the ubiquity of epigenomics data the causal functions of specific chromatin modifications have proved challenging to unravel this knowledge gap reflects limited approaches to dissect how chromatin modifications influence transcription quantitatively and contextdependently across diverse genomic features or variants in any given celltype here we propose to systematically interrogate the functional impact of specific and combinatorial chromatin modifications within tensofthousands of contexts in living cells using a novel modular epigenome editing platform we will produce the largest precision chromatinperturbation dataset to date and exploit it to capture multimodal functional responses at allelicallyresolved singlecell resolution across developmental lineages the unprecedented scale of the work will uncover the regulatory logic by which distinct chromatin states interact with genomic motifs sequence variants and cellular identity to shape quantitative gene expression patterns by integrating data and deploying genetic screens we will further identify the transacting and cisstructural mechanisms that underpin complex relationships our technology will circumvent the key limitations of existing approaches by excluding pleiotropy and redundancy whilst systematically isolating functional genome x epigenome interactions the cumulative insights will be used to build a predictive model based on rational rules for how specific changes in chromatin marks instruct or reflect gene expression states within specific contexts this will aid design strategies for precision medicine and create guiding principles to attribute functional significance to epigenome profiles in health and disease
pentecostal exorcisms in london creative and integrative rituals in a multicultural city

a common practice throughout much of the history of christianity the expulsion of demonic entities also known as exorcism continues to occur on a regular basis in the capital cities of europe these religious rituals are customary in pentecostalism a form of protestantism that grew exponentially in the last century especially in lain america and africa however although most of the studies about pentecostalism in the global south observe the importance of exorcisms the literature about this religious movements diaspora to europe focuses more on the integration of participants in a migratory context which leaves a gap in the analysis of these researches thus pentex aims to analyse pentecostal exorcisms in two pentecostal churches one from latin america and one from africa in london united kingdom by acknowledging these rituals creative in which outside practices are resignified and integrative in which they control and regulated the participants practices and social roles features furthermore pentex aims to observe the conviviality of pentecostals with other social groups in london and the role and adaptation of exorcisms in these interactions pentex will also analyse cases of violence in the city that resemble pentecostal exorcisms by observing if the churches spiritual warfare against evil and demonisation may materialize into violence and how the participants ngos that promote human rights and policymakers understand these cases
positioning of an artificial centrosome in a dynamic actin network

the centrosome is one of the main microtubuleorganizing centers in cells spawning filaments that define the cells shape and polarity peculiarly it is almost always positioned either at the center of the cell or at its periphery rarely in between precise centrosome positioning is crucial when positioned in the center the centrosome has the fundamental task of integrating information from the whole cell via the microtubule network instead its swift transition to the periphery is a key step of cell differentiation and polarization yet despite its importance the mechanism regulating this transition is unknown several factors are probably involved and regulated in the process including forces due to molecular motors or to the dynamics of the actin and microtubule networks in particular the role of the actin network inside which the microtubules are embedded is starting to be understood as a fundamental player yet the precise physical mechanism is not understood this project consists in resorting to the in vitro reconstitution of both the actin and the microtubule networks at the same time to study their interaction in a minimal biomimetic system using an artificial centrosome spawning microtubules and embedding it inside an artificial actin cortex in a dynamic state adding molecular motors to provide activity and confining it inside cellsized microwells we aim to understand how a sharp center to periphery transition can occur and what are the physical processes involved the possibility to add different purified components one at a time will allow exploring what role factors such as motor and polymerizationbased forces or the mechanical coupling to a contractile actin network play individually and combined in defining and controlling precise centrosome positioning the project paves the way for the understanding of centrosome positioning in cells but also represents an big step in the ongoing effort to build a synthetic cell from scratch
constellation optimization for continuous variable qkd

in todays highly interconnected world secure communication between distant parties is paramount quantum key distribution qkd protocols rooted in quantum mechanics offer a promising solution to this challenge by ensuring the generation of secure keys with high data exchange rates this project objectives seek to advance the state of secure data exchange by optimizing quantum state transmission within qkd protocols focusing on continuous variable qkd cvqkd we aim to pioneer novel algorithms that not only bolster security but also enhance cryptographic system efficiency by shaping constellations and fortifying security proofs cocovaq provides imperative contributions for secure communication safeguarding sensitive digital informationcurrently stateoftheart cvqkd protocols lack the sophisticated tools developed within the scope of optical communication systems such as adaptive methods for optimal constellation optimization which enable the transmission of secret keys at a high rate additionally existing security analyses of cv qkd protocols with practical discrete modulation often overlook critical symmetry aspects of the transmission algorithms that are imperative to establish security against arbitrary attacksin response our project endeavors to devise groundbreaking algorithms for constellation shaping and introduce symmetry properties to cvqkd protocols employing discrete modulation with provable security notably discrete modulation typically results in a substantial penalty on the resilience against attacks with the aid of constellation optimization this project aims at mitigating this penalty by between 10 and 20 orders of magnitude ensuring a theoretically secure exchange of secret keys of high rate at long distances finally cocovaq will showcase practical demonstrations of the entire system bridging the gap between theory and realworld applications
building a european strategic research and innovation area in direct synergy with eu and international initiatives for pandemic preparedness plus

be ready plus aims to extend and enhance the efforts initiated by be ready in preparing for pandemic response across europe the primary objective is to establish a robust and coordinated european partnership ep for pandemic preparedness fostering strategic alignment among member states associated countries and key stakeholders this will be achieved through the following key pillars1 paving the way for the future european partnership be ready plus will provide the necessary administrative and organizational support to ensure a smooth transition to the ep this includes drafting operational procedures governance frameworks preparing requirements to launch joint transnational calls and engaging key stakeholders to create a solid research and innovation framework 2 paving the way for pandemic preparedness the strategic research and innovation agenda sria established by be ready will be disseminated and updated to reflect new research needs and gaps be ready plus will also prepare the ground for everwarm networks of clinical study sites across europe ensuring rapid response capabilities for future health threats 3 maximizing the impact of be ready plus this pillar ensures comprehensive communication and dissemination activities leveraging digital platforms while maintaining crucial engagements it aims to engage a wide range of stakeholders from scientific communities to policymakers and the public to foster collaboration and increase awareness about pandemic preparedness be ready plus builds on the successful foundation of be ready expanding the consortium to 31 partners from 21 countries by the addition of 10 new partners and 5 new countries we will work in synergy with a broad range of european stakeholders and initiatives overall be ready plus will contribute to a more resilient europe by preparing a detailed operational framework fostering strategic coordination and ensuring readiness for swift response to future health crises