Dragon09/odtu_chatbot huggingface dataset:
regaining control of cancer at biological borders

during dissemination cancer cells must face and overcome several physiological borders including the immediate stroma for local invasion and the endothelium for longdistance metastasis at these critical junctures cell plasticity between epithelial e and mesenchymal m states could determine metastasis potential based on our preliminary data ideallypositioned cues emanating from the normal stroma contain the tumour in situ once this first border is breached rare cancer cellendothelial interactions trigger further dissemination through the vascular border moreover cancer cell plasticity is vital throughout this process enabling optimal response to distinct border microenvironments in bordercontrol we will build on our cuttingedge cell biology expertise and close collaboration with clinicians to define the molecular signals underlying these border crossings and gain unprecedented information on how cancer cells overwhelm these natural defences starting with patient tissues we will spatially profile the tumourstroma border to identify receptorligand pairs that regulate invasion we will use microfluidics to image catch and profile cancer cell crossings at endothelial hotspots and determine key molecular regulators of the process in endothelial and cancer cells building on our novel discovery of endosomally regulated em cell states we will test how em transitions impact borderbreaching potential these novel concepts will be investigated with interdisciplinary methods scrnaseq synthetic biology colour barcoded hts and our new technologies dynamically tuneable multicelltype migration and invasion imaging platforms to determine the specific interactionsmechanisms regulating border crossings finally we will take the molecular level discoveries from the cancerlimiting borders back to the patients assessing clinical relevance using designer tmas and expect to uncover novel biomarkers and therapeutically actionable targets
fast testing of multicomponent adsorption and diffusion in porous materials

the european green deal aims to reduce greenhousegas emissions by 55 by 2030 and achieve netzero emissions by 2050 the industrial sector accounts for ca 45 of carbon dioxide emissions stemming from energyintensive processes like power generation and chemical mixture purifications adsorptive separations by nanoporous materials have emerged as a promising platform for energyefficient industrial purification and carbon sequestration however to evaluate the performance of an adsorbent and design a separation process it is crucial to understand the adsorption thermodynamics and kinetics measuring multicomponent adsorption is complex and timeconsuming and adsorption kinetics are even more challenging to measure as a result multicomponent diffusion measurements are rare due to the constraints of current measurement methods by bridging adsorptiondiffusion studies and microfabrication the fastmap project will develop a new methodology to overcome the challenges of measuring multicomponent isotherms and diffusivities via a novel approach to realize outofequilibrium conditions combined with mass spectrometry the behaviour of fastdiffusing molecules will be thoroughly evaluated even in small adsorbent particles and in both single and multicomponent scenarios this approach will enable the rapid evaluation and selection of adsorbents for separation processes thereby accelerating progress towards the zeroemissions target of the eu the fastmap project bridges the candidates strong background in porous materials with the host groups extensive experience in microfabrication making it a feasible undertaking
advanced 4d printing technologies in corneal regeneration a pathway to restored vision

corneal blindness is the 3rd leading cause of blindness globally affecting 117mi people although the cornea is the most transplanted tissue only 1in70 patients in need receive a cornea due to a severe shortage of donor tissue3d bioprinting offers an attractive solution however existing technology cannot mimic the complexity of cornea tissue which is necessary to reproduce its optomechanical biological functionalitythe keratoprinter project thus proposes a highly ambitious approach to develop a 4d bioprinting suite that can deliver a fully functional biocompatible fullthickness nativelike human cornea the consortium combines worldclass partners to providea an innovative scalable cell source with high cell viability nativelike functionality in vivo for the different cell types in the cornea b several multimaterial bioink formulations which can reproduce the nativeenvironment heterogeneity extracellular matrix to deliver the optical mechanical biological functionality c singlecell bioprinting resolution with m accuracy inprocess monitoring for clinicallevel quality control at viable printing speeds d clinical handling technology for transportation logistics surgical implementation supported by complementary implementation of multiple bioprinting technologies e gmpcompliant cell manufacturing and bioprinting technologies supported by in vivo glp studies for fast translation to the clinical environment f early regulatory engagement augmented by a thorough regulatory and ethical analysis culminating in a comprehensive regulatory pathway to support future commercialisation and g a dedicated community of researchers clinicians healthcare providers regulatory and standardisation bodies patient groups technology developers industry to translate project results into targeted outcomes longterm impactsultimately keratoprinter aims to enable millions of people to receive visionsaving therapy by 2035
do plant volatiles shape species interactions in agroecological fields

plants use volatile organic compounds vocs to continuously communicate with antagonistic organisms such as herbivore pests and mutualistic organisms such as natural enemies of the pests and pollinators but we only know the basics of this communication and most of the studies come from laboratory experiments involving only pairwise or at most threespecies interactions how vocs mediate multitrophic plantinsect interactions in field conditions remain massively unknown in panoply i will be the first one to study how vocs shape plantinsect interactions in an unpresented longterm scale from the lab to the field i will use the scientifically and economically important perennial system of grapevine vitis vinifera and the leafhopper pest scaphoideus titanus which is the main insect vector of flavescence dore fd a lethal quarantine disease of threat to european grapevines i will test voc from aromatic plants that is a major group of plants containing vocs that are distinct from other plant species i will use single and mixtures of species of aromatic plants to 1 identify vocs that can affect life history traits of development host choices and reproduction of grapevine leafhopper 2 validate in the greenhouse and on common garden experiments how vocs affect insects behaviour and survival 3 test aromatic plants in analytical field experiments over the long term to understand the role of vocs on mediating multitrophic plantinsect interactions panoply will be the first demonstration of how vocs shape multitrophic plantinsect interactions in perennial plants answering this significant knowledge gap panoply will i reveal the mechanisms of plantmediated cues and their longterm effects on plantinsect interactions ii open new avenues for research in chemical ecology and agroecology and iii enhance crop health and insects biodiversity by preventing plant disease outbreaks through biological pest control and zeropesticides use
the activist the archivist and the researcher novel collaborative strategies of transnational research archiving and exhibiting social and political dissent in europe 19th 21st century

the project the activist the archivist and the researcher novel collaborative strategies of transnational research archiving and exhibiting social and political dissent in europe 19th21st centuries activate fosters intersectorial and interdisciplinary collaboration through the international research cooperation of 16 academic and nonacademic institutions from 7 countries across western central and eastern europe activates objective is to develop innovative methodologies and new knowledge as well as share best practice based on the principles of diversity inclusiveness and open science between researchers archivists curators and public educators through a reflective approach on social and political dissent in a longterm and comparative perspective by focusing on the transnational circulation of people ideas discourse practice and archives activate aims first to contribute to a new narrative on european protest and its relations with noneuropean spaces secondly the project engages reflective archival research and exhibiting practices to explore the role and impact of archives on different space and time scales approaching them as an ecosystem of active agents of memory and change through secondments and networking activate partners will share their expertise and best practice on material audiovisual and borndigital documents and data they will organise thematic seminars workshops training and public programmes to increase institutional outreach that will serve as a model for future endeavours ensuring cooperative relationships and impact on the wider community beyond the life of the projectactivate strives for new synergies between academic research and heritage institutions fostering better knowledge integration and promotion of dispersed cultural heritage which european democracies need to preserve with care
artificial rna regulators to probe control and design gene regulatory networks in bacteria

rna is common to all organisms despite its major function as the coding agent for protein synthesis an increasing number of regulatory roles have been assigned to rna in bacteria small rnas srnas constitute the beststudied class of noncoding regulators estimated to control 20 of all genes in a given organism most srnas affect gene expression by basepairing with multiple target mrnas resulting in either gene repression or activation srna regulators are modular versatile and highly programmable and thus have gathered momentum as control devices in synthetic biology and biotechnologymy group has recently established artificial srnas as a potent genetic tool to screen detect and characterize microbial phenotypes we have now extended this method by a novel sequencing approach called ligseq allowing us to map srnatarget interactions at the population level and in a high throughput manner we have further shown that srnas expressed from the 3 untranslated regions utrs of mrnas can serve as tuneable autoregulatory elements and thus bear ample possibilities for the design of artificial gene networks i therefore posit that artificial srnas are powerful yet understudied control elements of the synthetic biology toolbox with largely untapped regulatory potentials i thus propose to 1 exploit artificial srnas to investigate the molecular principles underlying target selection and rna duplex formation by bacterial noncoding rnas 2 harness the power of artificial srnas to study essential gene functions and the mechanisms underlying antibiotic resistance in bacteria 3 employ 3utrderived srnas as programmable feedback devices in synthetic gene regulatory circuits this combined work will generate the molecular framework to employ artificial srnas for synthetic biology applications and shed new light on medically relevant processes such as antibiotic resistance of microbial pathogens
avicenna live the immediate context of avicennas intellectual formation

avicenna ibn sn d 4281037 is among the most influential philosophers in history and the most important philosopher of the islamic tradition he is described as a mozarttype wunderkind who very early had completed his education and perfected his understanding of reality yet throughout his life avicenna was also an eager student of his teachers or himself a dedicated teacher to his students leading to the keyquestion of alive to what extent have avicennas personal relations with his peers influenced the formation and formulation of his own philosophy did he reform or reformulate his thoughts in light of his personal interactionsmodern scholarship on avicenna has often evaded these questions frequently referring to his autobiography according to which he supposedly never added anything to his views after his eighteenth birthday what is more scholars appear either unaware of the existence of sources that allow the examination of avicennas potential indebtedness to and interaction with his peers or deterred by the challenges involved in exploring them systematically as a result the immediate context of avicennas intellectual formation remained a surprisingly understudied area of research in defiance of its enormous potential for new insights not only into particular parts of his oeuvre but into his philosophy as a wholealive offers a radically new way of approaching avicenna by studying four unique source texts that enable us to circle in on his intellectual upbringing and development thereby providing an entirely novel paradigm for all future investigation in the field at the same time alive will make an important contribution to the digital humanities by furnishing an online platform that will facilitate the study of diverse and difficult textual corpora for both alive and future projects sharing these challenges
characterising thermal stress response in passerines from underlying mechanisms to evolutionary consequences

our ability to quantify and predict the magnitude of environmental global changes effects represents one of the major challenges of the 21st century these changes are characterised by a a gradual increase of ambient temperature through time but also leading to an increased frequency of climate anomalies such as heat waves habitat urbanisation in particular is a key driver of the increase of ambient temperature these temperature changes can drastically modify the phenology of species their geographic distribution food webs interspecific interactions but also life history trajectories behaviour and physiology of individuals yet endotherms capacities to adapt to thermal stress remain poorly understood the aim of this project is to evaluate the harmful repercussions of thermal stress on the physiology of organisms and on their life history trajectories reproduction and survival using a multidisciplinary and integrative approach i plan to conduct two experiments on great tits to assess the effects of thermal stress on different molecular and physiological mechanisms metabolic rates mitochondrial function markers of ageing stress hsp expression by manipulating temperature increase decrease mismatch under common garden conditions during development and growth period and follow various life history traits such as growth and survival patterns this project will provide exceptional insights to characterise variation of individuals life history trajectories and physiological responses to thermal stress and unusually warm temperatures such results will be key to pinpoint the mechanisms linking thermal changes to any potential effects on lifehistory trajectories which is crucial to monitor organisms responses to climate change we hope that this work will help to assess the fitness prospects of wild animals and potentially to predict extinction risks of animal populations in the context of global changes
welfare surveillance digital seams in the social safety net

automated data collection and algorithmic decisionmaking tools are increasingly integrated in social welfare policy where they are primarily used to determine which citizens are deemed eligible for social support which could be excluded and which might be accused of fraud despite being overtly presented as a benign technical advancement such welfare surveillance tools play a role in reshaping the structure of the social safety net they can support the work processes of welfare institutions with improved efficiency but can also reduce the human discretion of practitioners integrate hidden biases into evaluation procedures or cast a net of perpetual suspicion on citizens claiming a right to social assistance in their time of need the surveilwel project draws on a qualitative multisited ethnographic fieldwork within welfare institutions in slovenia where the automation of welfare eligibility assessments and fraud detection is both prevalent and technologically advanced to shed a light on these previously unexplored technologies and practices this project aims to map the work processes institutions and data streams involved in welfare eligibility tests and investigations of suspected fraud to critically examine the unintended and differentiated consequences arising with the introduction of digital and automated welfare surveillance tools and to evaluate how can digital welfare surveillance tools be reformed to produce better social and material welfare interventions by producing tangible applied knowledge on digital welfare surveillance this project seeks to inform slovenian and european welfare practitioners policymakers and citizens on the merits and pitfalls of digital welfare surveillance as they grapple with questions on the design structure inclusiveness and accountability of the future welfare state
early identification and remediation of literacy numeracy and socialemotional difficulties in kindergarten an examination of the efficacy of a multitiered system of support mtss

quality education for all is one of the eus top priorities however several european education systems are regularly pointed out as being underperforming inequitable or segregated the core objective of the 4year mtssk project is to adapt implement and assess the effectiveness and efficiency of a promising american educational approach for kindergarten in five european countries the socalled multitiered system of support mtss aims at reducing inequalities by training teachers to improve the socioemotional literacy and numeracy skills of all students and more particularly of the most vulnerable ones this model calls to adopt evidencebased teaching practices and to regularly and monitor students progress on the basis of objective data tier 1 to provide early and more intensive group interventions to students who do not progress as expected tier 2 and to provide even more intensive interventions to students who continue to need it tier 3 this model has been shown to improve equal opportunities of school success and inclusion by significantly diminishing the number of students with learning and behavior difficulties and referred to special education services however data is missing as regards comprehensive implementation of this model its efficacy in kindergarten its applicability in the european educative systems and the costbenefit ratio of this measure in addition to fill these gaps the mtssk project also aims at making accessible for stakeholders schools and teachers on a dedicated freeaccess website evidencebased syntheses intervention tools and skills assessment instruments developed for the study to disseminate the results and data in the perspective of the openscience framework and to make policy recommendations for eu and national authorities
corporate moral progress

within business ethics there is a longstanding debate concerning corporate moral responsibility the question of whether corporations themselves are the kinds of things that can be responsible for wrongdoing proponents of this view hope to vindicate our sense that firms are the appropriate targets of blame and censure however proponents have failed to decisively make their case and they have also failed to come to terms with the magnitude of corporate wrongdoing even if firms are possibly responsible this is far short of showing that corporations have the sensitivity incentives position to be anything but accidental agents for good let alone equal members of the moral community as corporations are some of the most significant actors in modern society this presents a real problem if it is right to think that corporations have genuine obligations then a sincere effort must be made to come to terms with why they fail to meet them as well as how to train firms to behave morally in the future in short corporations need a moral education given this cmp is broken into three objectives it will consider whether corporations are capable of being morally responsible for their actions it will uncover the challenges to corporate moral conduct it will determine whether and how to facilitate corporate moral progresscmp will meet these objectives with resources far outside of business ethics defending corporate moral agency involves using cuttingedge work within metaphysics philosophy of mind and philosophy of action understanding corporate wrongdoing requires reconceiving of how corporations make moral decisions and are motivated to act on them as well as the nature of their privilege in society and determining how to improve firms morally requires integrating work on moral education and moral progress with management disciplines such as strategic management by doing all of this cmp will pursue concrete ways to improve firms for good
personalized and subjective approaches to natural language processing

my project personae will make language technology lt accessible and valuable to everyone i will revolutionize research in subjective tasks in nlp such as abusive language detection and sentiment and emotion analysis by developing a new field called personal nlp yielding new datasets tasks and algorithms this new research area will explore subjective tasks from the perspective of the individual as information receiver making users active actors in the creation of lts instead of mere recipients this will allow for a more tailored effective approach to nlp model design resulting in better models overall each person has their own interests and preferences based on their background and experience these factors impact their views of what makes them happy angry or depressed over time language technologies lts can consider individual preferences however current research presumes a static view of subjectivity that a single ground truth underlies subjective tasks such as abusive language detection an assumption that lacks human variability and prevents universal access to lts languagebased ai such as virtual assistants is widely available but despite significant scientific advances most lt applications are inaccessible to individuals and their publics opinion has become increasingly negative gpt3s 2020 release boosted businessoriented applications such as copywriting and chatbots yet few that let people improve their livesfor example by controlling what they see on social media this gap becomes more pronounced for subjective tasksi will design subjective lts that can be adapted by individuals at will over time based on an ambitious meta approach able to generalize from existing disconnected work personae will rely on fully personalizable privacyaware algorithms that can be used by anyone it will reveal benefits of lt far beyond those of existing systems paving the way for future applications