Dragon09/odtu_chatbot huggingface dataset:
stapled peptide analogues as inhibitors of the ccr4not complex to regulate the mrna degradation

rna has gained significant attention in the past few decades due to its evolutionary role in gene regulations in the regulation process rna seldom works as an individual entity rather associated with several proteinprotein complexes ppcs and those complexes play a key role in mrna maturation typically mrna undergoes different posttranscriptional modifications and deadenylation is one of those posttranscriptional events in which shortening of the polya tail at the 3 end of mrna occurs and it plays a major role in mrna stability deadenylation is often regulated by different ppcs and dysregulation of these complexes severely impaired this process in fact in many cancer cells shortening of polya tail has been found due to the nonspecific deadenylation event therefore chemical modulators that can regulate the deadenylation process have immense therapeutic importance ccr4not is one of the most studied deadenylase complexes which actively participate in the deadenylation process several types of mrnaassociated proteins not4 bam and roquin are known which recruit rna to the ccr4not complex for deadenylation by interacting with caf40 through its evolutionary conserved site caf40 binding motif cbm domain moreover mrnaassociated proteins and rna both share the same binding surface of the caf40 protein therefore blocking the interaction between caf40 and rna would serve the inhibitory activity of the ccr4not complex towards the deadenylation process from crystal structure it has been found that the cbm domain of bam protein interacts with the caf40 protein through its helical surface here in this proposal we will design helical hydrocarbon stapled peptide analogues of cbm domain to exploit the proteinrna interaction by regulating the activity of ccr4not complex towards deadenylation process several biophysical computational and cellbased assays will be utilized to investigate the activity and mechanism of deadenylation process
submarine cables for research and exploration

this proposal responds to the call next generation of scientific instrumentation tools and methods 2022 horizoninfra2022tech01 the proposal seeks to directly address the challenges to develop a new worldclass research instrument integrating already existing nren and epos infrastructures and copernicus marine service from three european nations as well as paneuropean and panamerican institutions to disseminate fair compliant state of polarisation and distributed acoustic sensor data gathered from the same already installed live telecommunications submarine optical fibres in a temporally consistent and geographically dispersed way such an instrument would deliver innovative scientific instrumentation methods and tools as well as advancing the involved research infrastructures by developing new state of the art services and longterm data sets of unique scientific value this project will enable continuous recording of these types of data for research use by nrens for the first time thus supporting of diverse academic industrial and governmental user communities through the integration with epos data infrastructure existing research communities in solid earth epos and marine science emso industrial and public body communities can be complimented with entirely new types of data sets unavailable to them before which it is believed will lead to new areas of research
intelligent wearable system for enhanced personalized gait rehabilitation

one common consequence of specific medical conditions such as stroke or other brain injuries and certain operations is the need for post event rehabilitation in many cases the inability to walk properly requires professionally monitored gait rehabilitation gait rehabilitation is important to restore the gait performance of mobility impaired patients and gait training frequency represents a key factor for effective rehabilitation gaitrehub aims to develop an effective comprehensive approach to providing targeted homebased gait rehabilitation by integrating cuttingedge technologies from the areas of 1 computerbased design and modelling of customized smart insolesocks 2 wearable sensors and flexible embedded electronics realization 3 home assistive robots data analytics and artificial intelligence algorithms development as well as userfriendly software tool for gait rehabilitation and 4 preclinical validation of the developed holistic integrated and interactive system our rehub the gaitrehub consortium consists of international recognized institutions and organizations 4 from academic and 3 from industrial sector from belgium italy greece serbia chile and thailand gaitrehub will facilitate the exchange of knowledge skills and competencies throughout 199 personmonths of carefully planned secondments promoting international and interdisciplinary collaboration and disseminating the project results to all stakeholders this interdisciplinary and intersectorial project offers an excellent research and innovation environment for the personal and professional growth of the seconded staff members the outputs of gaitrehub will effectively enhance the personalized rehabilitation of neurologically injured patients and any other patient in need of gait rehabilitation while also sustaining ri collaboration within the consortium developing the potential for commercialization and working to improve health outcomes for our society
the manosphere pill pathways of boys and men into online male supremacism in portugal and ireland

this research intends to explore the discourses and social dynamics constructed on social media by manosphere groups particularly pickup artist incel and mgtow communities as well as its roots and if these discourses are successfully imported to the portuguese and the irish contexts comparing both the study will focus on the gender identity narratives created by men who identify with these groups or singular influencers with similar discourses pickup artists and mgtows share the red pill theory which is characterized by a rejection of the mainstream beliefs around gender ie the views of liberal feminists whom they believe are marginalizing men to deal with it they advocate for individual selfimprovement and reject political correctness and incels use the term black pill to describe the belief that there is no hope for them to have a romanticsexual relationship which can lead to radicalisation and support for violence against women the main goal of this research project is to examine the construction of narratives about gender in portuguese and irish communities of men online
initiative for european semiconductorbased largescale quantum computer

qlsi2 brings together the expertise of 23 partners from 9 countries with the ambition to demonstrate a cloudaccessible 200qubit semiconductorbased quantum computer by the end of 2027 in addition the consortium aims to demonstrate the implementation of meaningful use cases on this demonstrator the qlsi2 project will leverage the expertise of key european players rtos academic laboratories startups and large companies in complementary fields of quantum technologies from hardware to software to define and implement a roadmap towards such an ambitious goal the roadmap will extend its vision to the entire value chain including the supply chain particular attention will be paid to the industrialisability of the proposed solution in order to keep europe at the forefront of the race for quantum supremacy for a long time to come the roadmap will be implemented considering both heterostructurebased and fdsoibased routes in addition and following these two routes qlsi2 aims to advance both technology and manufacturing readiness to a level high enough to meet europes ambitions for the industrialisation of quantum technologies with a particular focus on scalability with these overall objectives and expected outcomes qlsi2 will have a significant impact on the field towards lsq
making access to the ocean affordable through our seasprings mooring solution

tfi seasprings is a novel mooring solution for floating offshore structures eg floating offshore wind turbines fowts stateoftheart mooring systems mainly approach the complex offshore mooring challenge by increasing the systems strength our patentpending tfi seasprings innovation changes mooring system response to reduce peak loads by 50 and wear and tear by 30 as a result mooring systems can be significantly lighter their lifespan can be extended and it allows use of smaller deployment vessels with greater availability and a reduction of 170kday on vessel hire these factors all lower capex and opex which can support fowts in reaching target levelised cost of energy lcoe of 90mwh from 160mwh this makes seasprings a very attractive solution to fowt developers and energy consumers the smaller footprint lighter chains and use of a semitaut rather than catenary system reduces environmental impact and crucially opens up new locations for deployment
high accuracy service harnessed trusted application and governance

the growing introduction of automated or even autonomous machinery on farms makes the need for good quality data more critical moreover the demand is increasing to log the outputs of those machines for analysis documentation and compliance however current datafiles sent to or retrieved from machinery lack quality standards they cannot be certified because any guarantee on the integrity of the used data and workflow is missing hashtag is therefore leveraging space assets and services to safeguard the reliability of data ensuring trusted application and governance within a period of two years three building blocks will be developed to proof our concept 1 standardising protocols logging and verifying prescribed tasks using machine data flows to assure asapplied maps are trustworthy2 standardising the processing of high quality eo data from copernicus into prescription maps3 using galileos high accuracy service and navigation message authenticator in a gnss receiver to provide trusted and accurate machine positioning integrating these components will result in a workflow capable of generating a transparant and authenticated data chain of eo data to asapplied maps this is relevant for current reality where food production and processing are international businesses with ingredients from around the world governed by food standards and environmental regulations our solution deploying space assets can be used anywhere in the world hence leveraging european knowledge and expertise to enable the next level of sustainable and regenerative farming international partners from serbia are included and use cases in brazil ukraine and indonesia will be explored hashtag will reach out to standardisation initiatives in agritech to promote its results and increase impacts the specific advantages that the european space infrastructure offer are important to develop globally acceptable and affordable private and public uptake of our space assets
vetting implicit normativity in climate economics

the project addresses the inherent presence of value judgments in current integrated assessment models iams of climate change impacts though widely used to inform public policy many aspects of iam design and use require making assumptions of an implicitly normative nature assumptions that are ultimately about the values that individuals and communities ought to pursue this raises a host of philosophical and methodological questions for which an interdisciplinary approach is needed which actors and in which contexts scientists at the model design stage policy makers at the decision stage etc should be in charge of making the normative choices that iams require what practices and protocols are best suited to facilitate the recognition of normative assumptions in iams the oversight by experts and stakeholders and if possible the resolution of the uncertainty that surrounds them to answer these questions the project will first propose a taxonomy of implicitly normative assumptions in iams then for each type identified it will aim to determine which of several approaches is best suited to deal with that type of normativity the resulting account will be a new model of iam research that indicates how one ought to proceed in concrete contexts of iam design assessment and use to achieve these objectives dr nappo will receive crucial training at politecnico di milano under the cosupervision of a philosopher of science and of a climate economist he will integrate his demonstrated competences in the epistemology of scientific modelling and climate change ethics with new skills which include firsthand experience with iam modelling practices and grasp of their mathematical underpinnings this training will allow dr nappo to not only advance the literature on iam normativity significantly beyond its current limits but to also contribute to making iam research more reliable and objective through an effective dissemination and exploitation plan
intervention on the determinants of and expertise in physical activity behaviours

the intervention on the determinants of and expertise in physical activity behaviours indeep research programme and training network will train a new generation of doctoral researchers who will gain expertise in innovative interdisciplinary research activity in physical activity pa and health promotion specifically the doctoral network will support the theoretical and applied development of the stateoftheart of determinants of pa and evidencebased population level pa interventions by promoting international interdisciplinary and intersectoral mobility across the pa for health sector progressing the work achieved in the jpi hdhl dedipac kh cost action ca19101 depass responded directly to the gaps and research needs in relation to the absence of european harmonised data on pa and their determinants grounded in depass the indeep network seeks to generate excellence in research and training providing graduates that will advance the stateoftheart in pa promotion through a comprehensive understanding ofthe associated determinants indeep addresses the need for a genuinely multidisciplinary approach to addressing the challenges of improving pa in youth and across the lifespan arising from the poor efficacy of existing approaches to pa change the network ultimately aims to provide an intervention development toolbox supporting the integration of determinants of pa behaviours behaviour change theory and intervention cocreation to aid in the development of evidencebased interventions which integrate topdown and bottomup intervention approaches outcomes beyond the lifetime of this project have the potential to have important societal and global impacts including contributing to achieve many of the bangkok declaration sustainable development goals sdgs including contributing to good health and wellbeing gender equality work and economic growth reduced societal inequalities sustainable communities and climate action
sustainable energy and alternative fuels from advanced intermediate renewable energy carrier technology

the aim of the seafairer project is to demonstrate at technology readiness level trl 7 the production of improved intermediate biofuels followed by processing in existing refinery infrastructure to deliver climatepositive dropin biofuels for maritime transport the feedstock biogenic waste residues will be transported in short distances to decentralised vertical intermediate pyrolysisbased reactor vinter units the seafairer project will collect characterise and process 3 different residual biomass feedstocks i rice husk from the valencia region spain ii biowaste sieving material from bavaria in germany and iii agave bagasse from southern mexico these feedstocks have been strategically selected from exclusively fair and residual sources without indirect land use change iluc issues the vinter unit will convert the biomass through a singlestage intermediate pyrolysis and postreforming process into three main products biochar raw oil intermediate biofuel and syngas the highquality biochar is suitable for european biochar certification ebc as carbon sink with vast agricultural and industrial applications the carbon sink will play a crucial role to achieve the climate targets of the maritime transport sector at commercial scale the intermediate biofuel which has a high energy density approx 32 to 36 mjkg branches out into two market entry pathways that leverage existing refinery infrastructure pathway a is designed to cover the immediate biofuel needs of the industrial maritime shipping sector which is under considerable regulatory pressure and has strict ghg reductiondecarbonisation targets such as the ones set out in fueleu maritime this pathway will target direct blends b10 to b30 of intermediate biofuel vinter raw oil on par with very low sulfur fuel oil vlsfo according to the iso 82172017 quality thresholds for marine fuels cf table 4 pathway b targets the medium to longterm demands of the maritime industrial shipping sector in this case the intermediate biofuel will be upgraded via hydrodeoxygenation hdo targeting higher blending capacity up to pure dropin fuel quality b50 to b100 on par with marine diesel oil mdo according to the iso 82172017 quality thresholds for marine fuels
prokurdish mevlid commemorations in turkey contested understandings of a popular islamic practice among rival ethnopolitical actors

this project is an inquiry into how actors strategically utilize religious repertoires and practices to articulate their political subjectivities it mainly focuses on alternative mevlid celebrations organized by the rival factions of the kurdish movement in turkey the sunni islamist hizbullah and the secular ethnonationalist kurdistan workers party pkk to commemorate the birth of prophet muhammad based on ethnographic fieldwork in diyarbakir the project will investigate how a local islamic practice has become a contested political arena in turkeys predominantly kurdish region where rival nationalist interests and imaginaries compete for political dominance and legitimacy particular attention will be given to the conditions embedded in local power structures and everyday practices which shape actors sense of identity and belonging drawing upon bells theoretical exposition on ritualization and connertons commemorative ritual theory this project will offer a new perspective to investigate the intersection between religion and politics by analyzing a politicized ritual environment in which various public expressions of kurdish and muslim identities are produced and disseminated the methodological novelty of this project lies in its attempt to combine ethnographic inquiry with political science to shift the analytical focus from organizational and structural level explorations to daily human practice and interaction in social contexts
an equipment for responsive adsorption assessment of dynamic adsorbents in liquid phase

liquid phase adsorption technology is crucial in industrial sectors focused on the separation purification or extraction of liquids or dissolved species such as petrochemical water treatment and pharmacologic industries however the characterization of the adsorption capacity of sorbents towards adsorptives in the liquid phase is still complex commonly used procedures for liquid phase adsorption characterization are tedious time consuming and manually done this is mainly due to the lack of standardized procedures and the absence of specialized instrumentation to automatize the measurements thus the transfer of liquid phase adsorption methods to a wider market of laboratory instrumentation has significant market potential for smes and promotes materials discovery in industry dynamic flexible porous materials such as metalorganic frameworks are already recognized as highly selective adsorbents suitable to revolutionize separation technologies in order to completely unlock the potential of dynamic porous sorbents industrial rd departments research institutes and academic institutions require advanced instrumentation for assessing the liquid phase adsorption capacity of dynamic porous materials dynalip aims to develop a novel advanced online liquid phase adsorption technology to perform quantitative and exact liquid phase adsorption measurements the successful project completion will allow the commercialization of an advanced device for laboratory use to promote the discovery and analysis of novel porous materials for highly selective liquid phase separation applications
glidesymmetric metamaterials for innovative radiofrequency communication and sensing genius

genius glidesymmetric metamaterials for innovative radiofrequency communication and sensing is an industrial doctoral programme led by top european actors of research and innovation in the field of radiofrequency rf systems with applications to aerospace communications and automotive sensing proposing novel scientific tools provided by glidesymmetric gs artificial materials or metamaterials it has recently been discovered that these metamaterials characterized by a special symmetry inside their constitutive unit cells possess marvelous electromagnetic em properties propagation in an ultralarge bandwidth strong isolation and high absorption features capable to address the open challenges of modern rf systems motivated by the increasing demand of ubiquitous connectivity and the growing automation of transportsgenius aims at training highly skilled and creative researchers capable to propose outofthebox solutions to industrial needs by means of their knowledge of physical properties of complex em systems the design of devices will be enabled by the development of suitable modelling methods circuitbased integralequationbased quasioptical shedding light on the properties of gs materials and providing fast and reliable data on their behaviour the intersectoral character of the training reflects its interdisciplinarity content researchers will benefit of academic expertise in gs metamaterials of the industrial knowledge of applicative needs and of fabrication and test facilities not commonly found at individual institutionsgenius will be the only international training program bringing together metamaterial physics and applicationoriented rf design its researchers will benefit of a dense network of contacts with scientists acquired during networkwide training events suitably complementing the skills acquired through research to improve their career prospects in the european and worldwide innovation sector