Dragon09/odtu_chatbot huggingface dataset:
allliquid phase janus bidimensional materials for functional nanoarchitectures and assemblies

asymmetry is a key structural feature in natural systems and allows for selforganization and unidirectionality of chemical transformations janus bi aims at developing an innovative protocol for the production of 2d materials bearing different functionalities on the two opposite sides the challenge is to implement the full process in the liquid phase and thus not resorting to solid phase transfer techniques which is the current stateoftheart with this new method janus 2d material colloidal inks can be directly produced and used as they are or for further solution processing of thinfilms andor more complex architectures the core of the project is the challenging protocol proposed which rely on the versatility of liquid phase exfoliation lpe of 3d crystalline powders of intrinsically layered species to produce 2d material inks and on the large availability of chemical functionalization approaches for 2d materials both aspects being soundly mastered by the pi of janus bi a first exfoliation produces quasi2d nanosheets which are aselectively functionalized with bulky groups so as to completely cover the exposed faces the functionalized quasi2d objects are then subjected to further lpe providing singlefaced functionalized 2d materials a second functionalization step is forced to happen on the uncovered face due to the steric hindrance of the pendant functionalities present on the other the settingup of a similar protocol requires a tight control over the nanochemistry and nanomorphology of the substrates employed resulting in a substantial gain of knowledge in controlled functionalization processes for 2d colloids once the guidelines for its successful implementation are identified the development of a whole library of janus 2d inks is enabled and many further goals can be targeted which are here exemplified by the construction of selfassembling superstructuresinterfaces and of photoactive and photocatalytic nanosystems
humanities rock research shaping the future of humanity

the humanities rock ern 20242025 builds upon the successes of the 20182019 2020 and 20222023 editions all organized by the university of ljubljana our core mission remains consistent to facilitate closer interaction between research and the general public our overarching objectives persist to enhance understanding of research and innovation activities to bolster public recognition of science and research education to underscore the researchers role in society and the economy to showcase the tangible impact of research on daily life and to inspire young individuals to consider research and scientific careersin an era where science denialism and skepticism towards scientists are prevalent often attributed to academias hesitance to engage with the broader public our 20242025 edition unites stem and ssh disciplines with the explicit goal of bringing research and researchers to the forefront our aim is to establish direct channels of communication with the general public reinstating credibility and trust in research innovation and those who drive these efforts while promoting public recognition of science and research educationthe 20242025 edition focuses on the expansive theme research shaping the future of humanity this theme underscores researchs pivotal role in shaping societys future and generating sustainable impact it aspires to mobilize citizens encouraging them to embrace innovative solutions and approaches while fostering greater societal acceptance and engagement with science and researchour planned activities are particularly geared towards children young individuals and those who may typically be less inclined towards science these activities encompass shows competitions exhibitions lab visits workshops discussions handson experiments eu corners open days and live interactions with scientists these events will take place in public venues and research institutions which will open their doors to visitors
twodimensional dipolar quantum gases fluctuations and orders

ordering in twodimensional 2d worlds is fundamentally different from what we know in 3d thermal fluctuations preclude conventional longrange order an unconventional ordering mechanism based on topological defects may occur the resulting order is topological remains fluctuating and intimately depends on the interparticle interactions many systems including frustrated magnets superconductors colloids and quantum gases exhibit such orders their topological origin confers them exotic properties of high technological interest yet still partly enigmaticin ultracold bose gases of magnetic atoms shortrange and longrange anisotropic dipolar interactions compete recently such gases were observed to stabilize despite attractive mean interactions through the effect of quantum fluctuations this fueled the discovery of several new phases of matter in such 3d gases a prominent example being supersolids which show simultaneous superfluid and crystal orders building on my expertise in both fields i propose to expand the rich physics of magneticgas orders to the exotic and yet unexplored 2d universe in a new experimental setup due to the unique variety of orders featured in magnetic quantum gases superfluid crystal plus their anisotropic features orientational orders and their remarkable intertwining an unprecedented playground for 2d topological ordering will be at hand by exploring the phase diagram i will aim to bring a deep understanding of ordering and reveal new quantum phases first i will focus on the repulsive regime and characterize the interplay between longrange anisotropic interactions and topological superfluidity i will then explore the fluctuationstabilized attractive regime here i will map the novel variety of orders that 2d worlds provide focusing on their ordering mechanism will reveal unprecedented phenomena such as topological supersolidity and superfluid liquidcrystals opening new research avenues
pharmacomodulation of epithelia for induction of antimicrobial peptide expression a disruptive approach to fight antibiotic resistance

the maximmun project aims at preventing and treating infections and situations of conflict between the host and its microbiota by developing a disruptive technology based on molecules that boost antimicrobial peptides amp of the innate immune system to face the problem of antibiotic resistance this highpotential technology may be relevant both in situations of endemic infections in the developing world and infectious or inflammatory pathologies in industrialized countries our objective is to establish the proofofconcept that among a series of hit molecules identified for their capacity to promote amps a small subgroup may qualify to lead molecules that can then be pushed into the late phases of the rd pipeline with the perspective of a phase i clinical trial to achieve this transition our project will range from the comprehension of microbial mechanisms leading to antibiotic resistance to the comprehension of amp regulations the identification of molecules and their optimization by medicinal chemistry and the characterization and evaluation of their protective efficacy in preclinical validation models thus we expect to develop innovative molecules as future antimicrobial drug candidates
advancing transregional border studies

the project positions tallinn university tlu to become a leading institutional and intellectual platform for scholarly exchange on border studies in partnership with the university of eastern finland uef and the university of amsterdam uva the uniquely designed eurasian border lab to be established and anchored at tlu will become a platform that catalyses transregional conversations and synergies between the euroamerican and asian border scholars and addresses the contrast between bordering as an increasingly complicated conceptual process and the more straightforward policyoriented approaches to borders the eurasian border lab through its online and offline activities will investigate bordering across the increasingly volumetric and virtual spaces crossfertilize research findings and reach out to practitioners policymakers and the public tlus vanguard position in advancing a transregional and multilayered approach to understanding key social political and environmental issues through bordering is expected to boost its scientific excellence enhance its institutional capacity to administer research and improve access to new research collaborations the partners complementing each other in their strengths and research foci will contribute key expertise and professional networks for knowledge mobilization while engaging actively in the joint research activities capacity building and attracting early career researchers
the european network of he cluster 4 industry national contact points

the mission of the ncp4industry cluster 4 industry ncp network is to set the basis of equal and consistent national contact points services on the industry sector by facilitating transnational cooperation between ncps within the cl4 industry and by fostering the circulation of knowledge good practices and available opportunities among industrial research and innovation communities the cluster 4 industry ncp network is the main source of practical information and assistance in participation in the cluster 4 industry related destionations and topic calls of the horizon europe framework programme the network will support the cluster 4 industry national contact points ncps and the european ri communitythe new consortium consists of 17 officially nominated ncp organizations and has an excellent representation from member states associated countries and widening countries nevertheless the entire network of cl4 industry ncps goes beyond these 17 project beneficiaries ncp4industry counts with all cl4 industry ncps not only by offering tailored support but also by including them in the planning of activities in order to meet their needs and the needs of their clientsthe ri community will benefit from ncp4industry accessing relevant background information about he industry related calls for proposals benefiting of matchmaking events mentoring and training activities and enhaning the access to funding opportunities thankful to knowledge transfer and communication measures the ncp4industry project outcomes will therefore lowering accessing barriers to european funding through a consistent level of european and national services provided by the national contact points across europe and beyond
tool for the analysis of information transfer in manuscript cultures

this poc project aims to alleviate the hesitancy of scholars working on texts preserved in manuscripts or other handwritten media to adopt advanced digital methodologies in their research by developing a free shareable flexible lowthreshold research tool which may be used as a starting point for researchers interested in studying the textual transmission of information in manuscript cultures it will take the form of a predesigned but flexible data model datainput framework and database solution through which data can be queried and exported for further analysis using relevant tools for statistical and network analysis it will be accompanied by a detailed user manual guiding users through the workflow from data input to analysis and tutorial videos explaining in nonspecialist terms to scholars of historical textual corpora the procedures leading from database design and population to the application of relevant analytical tools it will also contain a description of best practices and recommendations for the organization of collaborative teambased project implementation the tool will be designed in such a way as to be easily adapted to a wide range of research projects on any type of textual corpus regardless of its language or genre the tintramac research tool will be freely downloadable and nonprofit but aims to save significant time and resources for researchers and research projects focusing on largescale textual corpora based on handwritten sources from manuscript cultures promoting groundbreaking research by clearly demonstrating the benefits of employing such advanced digital methods in their fields at the same time it aims to lower the threshold of adoption by making the tintramac research tool freely available and it aims to flatten the learning curve for nonspecialist users by making it highly accessible
deciphering the melanomaniche cell interplay to identify novel treatments for metastatic melanoma

metastasis is the leading cause of death among patients with solid tumours including melanoma the most serious type of skin cancer despite tremendous progress in the development of effective targeted and immunotherapies patient survival is still low understanding the mechanisms regulating the dissemination of cancer cells is critical to uncover new vulnerabilities of aggressive tumours whilst previous research has mostly focused on cellintrinsic properties of cancer cells the aim of this project is to define the impact of signals from the cancer cell niche on melanoma dissemination in vivo with the longterm goal of discovering drug targets and developing new pharmacologic strategies against metastatic melanoma building upon previous results from the ablain laboratory i will elucidate and target the mechanism by which melanoma cells change their adhesion properties in response to local igf1 signalling additionally new interactions between melanoma cells and niche cells will be identified by scrnaseq in human metastatic melanoma tissue obtained from the hcl hospital and recapitulated in reconstructed human skin systems and in zebrafish models i will investigate the role of these interactions in the regulation of melanoma cell behaviour by combining genetic and pharmacologic manipulation with cuttingedge liveimaging in vitro and in vivo this fellowship through advanced interdisciplinary and intersectoral training and collaborations will serve as a launchpad for reaching a position of academic independence whilst facilitating a transfer of knowledge between myself the crcl and several collaborators and addressing an unmet need for a better understanding of the behaviour of aggressive tumours i will use this award to expand my skillset build an international professional network and establish myself as an expert in the field of cancer cell behaviour producing high quality cuttingedge research with strong translational potential
cohesin and its regulators from chromosome dynamics and nuclear architecture to human diseases

cohesin is an evolutionarily conserved multiprotein complex that belongs to the structural maintenance of chromosomes protein family it can topologically entrap dna molecules mediating sister chromatid cohesion a function important for accurate chromosome segregation and dna replicationrepair it has been recently discovered that cohesin can generate and maintain dna loops by an atpasedependent in cis dna tethering activity called loopextrusion critical for organising chromatin architecture and regulating gene transcription and as such thought to be important for cell differentiation and development however the molecular mechanisms by which the cohesin complex achieve these key cellular functions remain to be elucidated mutations in genes coding for cohesin and its regulators lead to a class of developmental disorders collectively called cohesinopathies and have been found in several types of cancer nonetheless the pathogenesis of these devastating human diseases is poorly understoodcohesinet aims to answer outstanding questions in the field of cohesin biology by a highly innovative research programme this consortium will investigate fundamental mechanisms on how cohesin acts during chromosomal cohesion and loop extrusion identify regulatory modules of cohesin functions and get insights into the molecular bases of cohesinrelated diseases these ambitious goals will be achieved using multidisciplinary hypothesisdriven and exploratory approaches while promoting a culture of communication and cooperation among academic and private institutions across the european union a team of ten phd students will be trained by the cohesinet consortium to address these scientific questions and be empowered with skills that will enhance their career perspectives while experiencing firsthand the value of open science and the importance of inclusion transparency accessibility and integrity in scientific research
nanoencapsulation of bioactive compounds from plant by products to produce sensitive skin cosmetics

the main aim of the nanocosmos project is to create a european multidisciplinary and intersectorial network to harness the recovery of valuable bioactive compounds from plant byproduct matrices for nanoapplications in the cosmetics industry the project will ensure i exchange of knowledge on bioactive compound properties ii optimization of green extraction processes of such compounds from plant byproduct materials iii creation of innovative nanoencapsulated biocomponents for cosmetics formulations mainly targeted on human sensitive skins nanocosmos project will aim at enhancing cross fertilization in the area of bioactive compounds from different plant byproduct materials which will result in a more costeffective use of skills and resources in circular bioeconomy it will also involve handson practice in different analytical methods in connection with industrial scaleup performed by both young researchersphd students esr experienced researchers er and experienced academics science and business cooperation will allow the development of a joint research network to address current needs in the area of the cosmetic industry the project will promote university business dialogue and partnership especially in the context of greater involvement of practitioners in the preparation of esr career development
european thematic network for unlocking the full potential of operational groups on alternative weed control

oper8 will setup a selfsustainable multiactor euwide thematic network to support and promote solutions for nonchemical weed control by building upon the knowledge and outcomes of 8 operational groups 7 countries and stimulate knowledge exchange among all relevant actors and stakeholders with the ambition to achieve a high impact and improve the sustainability of the european agricultural sector the synthesis of partner ogs is based on their expertise geographical location novelty of solutions as well as the established connections with the akis actors special emphasis has been placed on collaboration schemes among these ogs that progress at a different pace providing the opportunity to learn from the early birds which will bring handson experience the project will follow a multiactor approach implement a bottom up and top down model and build upon cocreation cross fertilisation activities to help farmers access uptodate knowledge tools and techniques applicable to specific conditions and needsto this end oper8 will i establish a stakeholder engagement processes to assemble the 7 national networks nns ii capture the drivers barriers and root causes of lack of nonchemical weed control adoption as part of a bottomup approach iii establish crossfertilisation activities within and between the nns to cocreate showcase and evaluate nonchemical weed control methods and iv deploy knowledge transfer tools and techniques workshops demo farms cap measures to adapt and scale up alternative weed control solutions and ensure their diffusion across eu a series of actions eg demonstration activities policy recommendations and training sessions for integrating project results into the cap national strategic plans will be implemented strengthening the akis and ultimately paving the way towards a transition to a sustainable agriculture in adherence to the green deal and its farm to fork strategy
continuous enzyme evolution solving bottlenecks in enzyme engineering to design nextgeneration biocatalysts

directed evolution has revolutionized the application of enzymes in industrial settings by allowing users to tailor the properties and activities of biocatalysts to their needs but classic directed evolution is notoriously labor and timeintensive as it manually stages mutation selection and amplification cycles in contrast continuous evolution ce approaches aim to achieve these steps within a replicating organism making it possible to engineer efficient enzymes in a matter of days rather than months or years unfortunately current ce approaches are typically applicable only to model enzymes with little industrial valueto unleash the full potential of ce we will develop a scalable lowtech ce platform which is readily applicable to biocatalysts that provide valueadded products toward this end we will merge a versatile selection system we recently developed with strategies to diversify the genes of targeted enzymes in vivo and an autonomous setup to grow bacterial populations continuously combined the resulting ceplatform will enable us to engineer biocatalysts along many and long evolutionary trajectories moreover analyzing the fate of these populations by sequencing will allow us to map the sequencestructurefunction relationships of these biocatalysts based on the systematic datasets generated in these efforts we will train machinelearning mlmodels to predict functional sequences lastly in a mldirected ce approach we will establish a designbuildtestlearn cycle to improve models and guide ces toward promising but otherwise inaccessible sequence spacesoverall contizymes will overcome unaddressed challenges associated with the application of biocatalysts that promote soughtafter cc chalogen and cnbond forming reactions we will not only engineer these enzymes at an unprecedented rate and scale but also map their fitness landscapes and take a critical step toward the ondemand design of nextgeneration biocatalyst
twinning to build an industrial ecosystem around the core principles of industry40 and the digital twin

core innovation centre core is a private nonprofit research organisation based in greece and founded in 2021 as a full subsidiary of core innovation technology oe focusing on industry40 technologies like machine learning iot edge and cloud computing innovation management and communication the vision of core is to become the biggest ri centre in southeastern europe in the fields of industry40 core aims to create an industrial ecosystem composed of manufacturing companies and knowledgeresearch institutions around the core principles of industry 40 such as automation zerodefect manufacturing and flexible production based on a number of core technologies such as machine learning robotics bigdata and digital twins this vision will be materialised through the development of industry 40 test labs which are practical environments where companies and research institutions develop test and implement industry 40 solutions under realistic conditions as well as codesign the associated digital processes and new business models the overall twin4twin goal is to raise the research profile of core as well as the research profile of its staff in the field of digital twin technologies in parallel with the objectives twin4twins concept approach is divided into four clusters a digital twins scientific excellence b research and innovation management upskilling c business development and d exploratory research project to do that core will run the twinning exercise with leading eu organisations namely ita from spain reduced order models research in digital twins scch from austria big data real time streaming technologies and ssf from switzerland test and demo platform to be used as use case and provide the replication potential towards the greek smart factorytwin4twin aims to reduce the disparity in production between greece and topclass leading countries through knowledge transfer in smart manufacturing technologies