Dragon09/odtu_chatbot huggingface dataset:
mythical discourse and religious agency in the puranic ecumene

the puranas primordial texts constitute the most voluminous and enduring genre of sanskrit literature these anonymous texts narrate the mythic cycles associated with the major deities of hinduism visnu siva brahma the goddess etc the puranas have also been integral to processes of placemaking by creating maps of geography and celebrating the salvific potential of sacred sites in myths that imbue the landscape with divine agency while many important puranas were first recorded and circulated in the first millennium cea time of significant social change marked by the flourishing of regional devotional movements and innovations of temple and imagecentered religious practices the genre has remained a living tradition through the colonial period until the present day despite the traditions centrality for cultural production in south asia we know very little about their historical embeddedness as the puranic composers and transmittersin accordance with the anonymity characteristic of the genredisguised their own historicity behind claims of primordiality and divinely inspired teachings more than just a body of literature the puranas are a dynamic mythical discourse purana makes a critical intervention in the field by tracing the composition transmission translation and agency of the puranas as a transregional and transhistorical process involving multiple actors audiences and geographic contextsfrom hindu scribes and persian poets to portuguese jesuits and khmer rulers adopting a longue dure perspective we argue that the puranas mythical discourse underlies and unites the religiopolitical culture of the sanskrit cosmopolisestablishing what we call a puranic ecumene a vast part of the inhabited premodern world united by a distinctive mythical discourse a hegemonic vision of the integration of society and cosmos and a remarkable way of anchoring the present in the continuing ancient past
microfluidic ev quantification for pointofcare crc diagnostics

the quantev project aims to revolutionize the landscape of colorectal cancer crc diagnostics through the development of a groundbreaking pointofcare poc platform leveraging the emerging potential of extracellular vesicles evs as robust biomarkers for crc this interdisciplinary endeavor combines cuttingedge microfluidic technology with advanced analytical methods to enable the sensitive rapid and costeffective detection of crcspecific evsby designing fabricating and characterizing a microfluidic ev enrichment module the project pioneers an innovative approach for the selective capture of crcassociated evs from patientderived samples simultaneously a stateoftheart fluorescencebased ev detection and quantification module is developed to provide accurate and realtime analysis of the captured evs these two modules are seamlessly integrated to create a labonachip diagnostic platform capable of detecting crc at early stages with exceptional sensitivity and specificityfurthermore quantev places a strong emphasis on translational research collaborating closely with clinical partners to validate the platforms performance using patient samples the project also incorporates extensive open science practices to foster collaboration transparency dissemination of research outcomesupon successful completion the quantev platform holds the potential to revolutionize crc diagnostics offering a costeffective noninvasive and efficient alternative to current screening methods beyond crc the technology developed in this project can pave the way for the application of evbased diagnostics in various other diseases driving advancements in personalized medicine and improving healthcare outcomes
learning to appreciate aesthetic values

the overarching goal of the project is to define aesthetic learning as a complex multilayered mental process from an empirically informed philosophical perspective the research project will rely on a the philosophical literature concerning aesthetic values and b psychological evidence in cognitive sciences about the acquisition and development of perceptual and affective discriminatory capacities the outcome of the project will be a model of aesthetic learning capable of exploiting the most recent advancements in the cognitive sciences within a rigorous philosophical framework by focusing on such basic and uncontroversial components of aesthetic appreciation as perception and emotions the project will establish viable criteria for the definition of aesthetic values that can be perceptually learnt and for the definition of aesthetic appreciation such a model will be submitted to experts in art teaching made available for experimental testing and introduced to broader audiences thanks to the fellowship the er will fulfill the career goal of becoming an established researcher in the field of philosophical aesthetics either with a permanent position or as a pi of a research project in a european university
fully electrically controlled ultrafast chiral light handedness switching in organic lightemitting devices

chiral light with a rotating electromagnetic field is revolutionizing optoelectronics quantum optics and spintronics this unique light delivers either left or right optical information based on its polarization similar to how alternating electrical signals transfer sound and images despite centuries since the discovery of chiral light achieving electrical modulation of its handedness in lightemitting devices remains a significant challengetraditional methods of switching chiral emission handedness eg inverting material stereochemistry or mechanically rotating optical filters encounter practical limitations complicated fabrication and slow switching speeds however electrical modulation of light handedness simplifies manufacturing processes and enable insitu controllability this allows for not only the switching of handedness but also capability to do so at high frequenciesmy approach departs from prior research instead of focusing on emitters i will investigate the largely overlooked molecular environment of these emittersthe host materials these materials account for 90 of hostemitter blends and significantly influence the transport properties of organic lightemitting devices but their role has been surprisingly neglected in previous researchmy objective is to create a chiral environment for emitters using chiral host materials thereby manipulating electron behavior such transport behavior will polarize the entire recombination processes making the chiral emission handedness dependent on current flows integrating these materials into a new chiral organic lightemitting transistor the goal is to achieve ultrafast handedness switching of highly polarized chiral emission within a single devicedespite notable challenges creating such light sources offers direct chiral light generation and rapid control over its handedness potentially revolutionizing future optical communication imaging and display technologies
founding a global image data ecosystem

digital image data is a crucial part of biological research fueling an exponentially growing body of research output a surge in volume and diversity of bioimage data owing to the fast developing imaging technologies has brought to light many challenges including in sharing open image data resource owners research infrastructures as well as grassroots communities are actively tackling these challenges by developing file formats ontologies metadata models to ensure that shared data is in line with the fair principles however many of these solutions remain regional and a global coordination effort is necessary to enable seamless image data sharing this project will lay the foundation for a global image data ecosystem gide that connects different biological and biomedical image data resources across the globe to allow metadata and data sharing gide will bring european research infrastructure and image data resource owners together with their counterparts from australia and japan to develop the basis of image data sharing these interactions can then be used as a blueprint to engage with the wider global bioimage data community while strengthening the position of european infrastructures in the landscape to enable partner resources and research infrastructures to communicate in one language coordinated technical development towards use of harmonised imaging ontologies and metadata models will be carried out proof of concept implementations using harmonised image data and metadata will showcase the project developments and encourage adoption of these recommendations globally these developments will also lay a crucial and strong foundation to build a future federated image data ecosystem on together global efforts towards gide will provide a necessary framework for bioimage data to grow into a democratised resource enabling innovative research in europe and across the globe
noise in fluids

fluids in complex regimes show random features the aim of this project is approaching several questions around the randomness of fluids by means of a theory that could be called stochastic fluid mechanics the distinctive feature of this theory opposite to others that investigated the stochastic features of fluids is that it is based on the usual continuum mechanics equations in particular the navierstokes and euler equations but suitably modified by the presence of random elements like an additive or a transport type noisestochastic equations of fluid dynamics have been studied already for three decades and the number of foundational results is very large however two basic directions have been explored only partiallya the origin and the form of noise in fluidsb the consequences of the presence of noisethis project will make progresses in these two directions describing the noise near boundary due to vortex productions including the question of intrinsic stochasticity at the boundary the propagation of additive noise at small scales to a transportstretching noise at large scales the consequences of transport noise on eddy viscosity enhanced dissipation enhanced coalescence and other applications in turbulence and geophysics the most ambitious core of the project is putting together these pieces in a picture that explains the mechanism of regularization by noise for the 3d navierstokes equations the additive noise at small scales is responsible for a transportstretching noise at larger scales which could prevent blowup of high intensity vortex structures we have already proved recently that a noise of transport type only has this regularization effect but stretching amplifies vorticity and new progresses are needed to cope with both processes we aim to use the experimentally observed fact that small scale velocity should be approximately orthogonal to vorticity in high intensity regions
clinical portfolio strategy for regenerative muscle stem cell therapies

myopax is a women founded company with locations in germany and in denmark myopax uses a proprietary patented firstinclass stem cell technology to become the leading engineering platform for the treatment of skeletal muscle wasting disorders in europe alone more than 20m people are affected by the devastating consequences of muscle wasting only palliative care is availablewe developed a method to produce pure and highly regenerative muscle stem cell populations phsats primary human satellite cellderived stem cells preclinically phsats potently build new muscle and refill the muscle stem cell pool longterm effect we are setting up three stem cell platforms for todays unmet medical needs 1 satori original phsats patented in eu2021 us2022 to treat local muscle defects with a single injection 2 satgeno genetically corrected phsats in genetic muscular dystrophies a patent has been filed in 2022 satori and satgeno are clinicaltrialready firstpatientin is planned for q3 2023 3 satuni muscle stem cells derived from induced pluripotent stem cell ipsc as a universal allogenic muscle stem cell product we will deliver preclinical efficacy in 2024 for thus offtheshelf productwith women techeu we aim to further develop our clinical strategy including an international regulatory and ip strategy detailed market analysis and network building with kol the mentoring will help us to prepare the fundraising round which includes company valuation strategies preparation for due diligence and financial planning the support will get myopax venture capital ready to leverage the technological potential and expand the clinical portfolio giving back muscle power to those who need it
userdriven applications and tools for climateinformed maritime spatial planning and integrated seascape management towards a resilient inclusive blue economy

oceanids aims at building userdriven applications and tools which act as an enabling technological layer for regional authorities stakeholders in order to achieve a more resilient and inclusive systemic pathway to a blue economy in coastal regions brining spatial and nonspatial data services under a singleaccess window platform for climateinformed maritime spatial planning cimsp the project will allow a more integrated seascape management of coastal regions the project delivers a decision support tool the oceanids decision support platform odsp with an overarching target to collect harmonise and curate existing climate data services making data accessible reusable and interoperable for the development of local adaptation strategies oceanids facilitates access to knowledge data digital services critical for better understanding and managing climate risks enhancing adaptive capacities and supporting transformative innovationsin addition oceanids sees inclusivity as an enabling and required factor towards a blue economy the project has a strong focus on behavioural change both on individual as well as on a systemic level enabling participating regions and communities to better understand and use potential social tipping points and systemic leverage points to accelerate transformative changes towards climate resilience to achieve this it promotes inclusive and deliberative governance through meaningful engagement and dialogue between citizens and stakeholders this will be achieved using casespecific tools ie ephemeral social networks leveraging local citizens assemblies for bottom up deliberation cultivating a culture of civic engagement thus empowering individuals to take action in their own communities finally the project will contribute to mobilising sustainable finance and resources towards adaptation at scale and closing climate protection gap
integrated battery and energy management system for secondlife battery energy storage

octaves product consists of a secondlife battery energy storage system equipped with octaves cuttingedge battery and energy management technology the novel technology relies on a deep integration of the battery management system and the energy management system it makes the raw battery cell measurements available for optimisation of the battery systems charging strategy the data are sent to octaves battery cloud where it is used in advanced machine learning methods and digital twins of the cells are created to extract useful insightsthis innovative technology opens up a range of improvements in the operation of the system such as optimal control extended lifetime improved monitoring and enables predictive maintenance it is particularly useful for secondlife battery storage the goal of this project is to bring octaves product to the market by lifting the technological readiness from trl 5 to 8 and prepare the go to market via the blended finance modality
identifying strategies to reduce osteoporosisdriven bone loss through the development of microphysiological bone remodelingonchip tools

osteoporosis is a common skeletal disorder characterized by imbalanced bone remodeling where osteoclast activity is exacerbated leading to increased bone degradation and fracture risk the socioeconomic burden of this disease is elevated in the eu and is expected to further increase in coming years highlighting the need of improved disease models and drug screening platforms in preclinical research organonchip ooc technology has been demonstrating high potential to replace anima testing in drug screening and pathophysiological modeling but current output measurements in ooc applications are still mostly limited to endpoint assays or require large volume of sample in addition bone ooc models competent for exacerbated bone resorption the main consequence of osteoporosis are still lacking indicating a need for improved and more representative modelsto address this issue in this project i aim to identify and validate potential strategies to reduce osteoporosisdriven bone loss through the establishment of a boneonchip model with integrated sensors for online detection of bone degradation biomarkers i will combine knowledge from disciplines ranging from microfabrication tissue engineering molecular biology imaging and electrochemistry to fabricate osteoclast resorption biomarker sensors and integrate them in ooc models that faithfully replicate the bone microenvironment my experience in osteoclast biology will be integrated with the extensive expertise of the brigham and womens hospital harvard medical school in tissue engineering microfabrication and materials science for the successful implementation of this proposal these experiences will provide the optimal training environment not only to become a leader in organonchip disease modelling but also to position myself advantageously to succeed in nonacademic sectors
shaping intestine epithelium using viscoelastically dynamic matrices

intestine epithelium ie compartmentalization and morphogenesis are profoundly influenced by intrinsic biochemical signals and microenvironmental cues in the extracellular matrix ecm especially viscoelasticity recent studies have revealed substrate mechanical properties have clear influences on intestine stem cell isc fate ie polarity selforganization and morphogenesis however most of these investigations were performed in constant and static conditions neglecting the active and dynamic nature of in vivo ecm furthermore whether and how dynamic matrix viscoelasticity contributes to the emergence of symmetry breaking and tissue regionalization in early intestinal morphogenesis remains elusive so far in this project we propose to use dynamic hydrogelbased matrices with lighttriggerable changes in viscoelasticity to study the transduction of molecular mechanosensing into collective cell dynamics during symmetry breaking and tissue patterning in ie development we hypothesize that anisotropic substrate viscoelasticity could heterogeneously activate mechanosensing pathways in iscs and affect isc proliferation and differentiation leading to changes in cell activities sorting and tissue segregation in brief with dynamic substrates we will create viscoelastic patternsgradients by in situ light patterning and elucidate ie dynamics related to the emergence of cell shape migration isc fate and tissue compartmentalization as functions of the mechanical stimuli we also aim to identify the molecular principles of ie mechanotransduction which will improve our understanding of ie development morphogenesis and homeostasis the knowhow from this project will also enable the fabrication of artificial intestineonachip devices for further developmental studies relying on the multidiscipline approaches this action will greatly enhance the competence of the researcher as well as bring added value in scientific and societal aspects for the eu
metal additive manufacturing with sinterbased cold metal fusion technology for mass production of metal parts

commercial am technologies for metal parts have restricted material selection and high production costs that limit their application to prototypes and small batchescmf is a patented process to produce metallic parts in which we successfully merge the sinterbased approach used in powder metallurgy with the selective laser sintering the am equipment widely used to form plastics parts our innovation is based on our unique metal feedstock that can be processed on existing systems for plastics in the marketwith this new approach we offer metal manufacturers i an innovative technology that provides the freedom and adaptability to produce more complex parts with a lower capex ca 95 as we have adapted the process for the costefficient plastic am machines in the market ii the series production of metal parts via 3d printing with costsaving potential of up to 90 when scaling production to larger series 100000 parts and available with a great variety of materials
opening the electricity ecosystem to multiple actors in order to have a real decarbonization opportunity

opentunitys mission is to create a flexibility ecosystem reducing interoperability barriers and favouring the use of standards in order to decarbonize eu grids and put the enduser in the spotlight grid operators prosumers market actors etc will be supported by opentunity via innovative methodologies backed by advanced interoperable software modules in order to provide them with new features and services related to 1 technologies to boost flexibility in prosumers environment 2 technologies for grid operators to better manage grid operations opentunity will also evolve adapt and integrate a federated data space infrastructure in which actors from different fields will share services and find synergies among them in order to create a reliable energy system in which different verticals electromobility gas oem etc will be able to seamlessly collaborate with each other opentunity will be demonstrated in 4 different countries greece slovenia spain and switzerland benefitting 26852 citizens and reducing 9122 mtco2eq ghg emissions and energy poverty by 30 by 2032
improve safety in polymedication by managing drugdruggene interactions

polypharmacy multimorbidity and genetic heterogeneity can affect drug efficacy raise the risk for adverse drug reactions adrs and increase healthcare costs adrs are among the leading causes of death in developed countries and a major cause of hospitalization drugdrug interactions ddis and druggene interactions dgis are highly interconnected and require a holistic approach to improve safety of our citizens however investigations on reallife drugdruggene interactions ddgis in clinical trials are unfeasible due to combinatorial explosion high costs and ethical concerns hence significant knowledge gaps exist furthermore the lack of participation in managing their conditions might be excessively demanding for polymedicated and multimorbid citizens safepolymed will develop a novel and innovative framework to define assess and manage ddgis for physicians and individual patients resulting in education and empowerment of citizens as well as in reduced healthcare costs by improving patient safety the main objectives of safepolymed are 1 development of a novel evidencebased risk scoring system using machine learning on large realworld datasets to identify patients at risk 2 identification and validation of patient reported outcome measures for multifactorial patient safety in collaboration with european patient organizations 3 development of an electronic tool to empower patients by allowing them to properly manage their therapies check for and educate about ddgis and collect their patient reported outcomes 4 mathematical modelling of clinically relevant compounds to derive individualized dose adaptations for safe and effective dose regimens in case of ddgis accessible via a webbased decision support system with tailored information for either citizens or physicians and 5 validation of the developed safety tools in a proofofprinciple study including representative patient cohorts from different european clinical sites