Dragon09/odtu_chatbot huggingface dataset:
brownian particles in nonequilibrium baths

the power of thermodynamics comes at the expense of certain assumptions and idealizations an important premise is the concept of a thermal bath which is in contact with the examined system typically such baths are idealized as an infinite reservoir of heat that remains in equilibrium regardless of whether the system in contact is in equilibrium or not such description however is only valid when the bath relaxation time is much faster than typical time scales of the system otherwise a driven system excites the bath out of equilibrium and will interact with nonequilibrium fluctuations recent experiments using colloidal particles within viscoelastic baths whose relaxation times are comparable to colloidal timescales have revealed surprising and only poorly understood novel behaviors which are attributed to the nonequilibrium properties of the bath examples include particle oscillations inside moving optical traps a fastened hopping dynamics across potential barriers an up to 100fold enhanced rotational diffusion of drifting particles but also the presence of about onemillionfold increased magnus forces here we propose a series of novel experiments aiming to uncover the impact of a nonequilibrated bath on the behavior of externally driven colloidal particles but also to exploit such effect for applications in those experiments we will investigate how nonequilibrium surroundings affect erasure processes of logical information or modify the design of optimal finite time protocols in addition we will construct an unprecedented microscopic engine which unlike conventional heat engines is not operated between two heat baths but which is periodically coupled to nonequilibrium baths with different relaxation times the selection of the examples being pursued within this proposal has been chosen not only to demonstrate the manifold consequences of nonequilibrium baths but also provide possible overlaps beyond the field of soft condensed matter
nonlinear dynamics of fluctuating twodimensional materials in action

twodimensional 2d materials are unique platforms for studying fundamental science they bridge the gap between the world of atomic scale dynamics and the world of macroscopic mechanical vibrations owing to their small size they can enable exploration of research areas that lie at the forefront of classical and quantum technologies but at the same time their noisy and nonlinear nature limits their performance this combination of fluctuations and nonlinearities brings to light a new regime of mechanics that has remained largely untapped and that if wellunderstood can open a wide range of trajectories in highperformance sensing and labona chip devicesncanto aims at elucidating this strong interplay between nonlinearities and noise at the atomic scale and will leverage the acquired knowledge to engineer 2d nanomechanical devices that i offer extreme frequency stability and ii enable robust and highlysensitive singlecell sensing to realize this vision i will explore the influence of a range of nonlinear dynamic phenomena on two important noise sources namely frequency fluctuations and biological noise my approach will combine stateoftheart modelling and experimental techniques to deliver novel designs that utilize nonlinear dynamic phenomena at their core these designs will quench frequency noise in 2d resonators for breakthrough performance on the one hand and will enhance biological rhythms at the singlecell level for robust drug screening on the other by linking stochastic dynamics nanomechanics nonlinear dynamics and structural optimization i will develop a multidisciplinary research area that will enable a groundbreaking leap forward in the utilisation of 2d materials as nonlinear sensors in frequencybased metrology and biohealth ncanto will thus not only herald new frontiers in nanomechanics but will also open new routes towards engineering nanotools for rapid screening tests in drug development and personalised medicine
legonucleotides for detection

sensors have a vital importance on human life detecting diseases or contaminants that endanger the environment a widely pursued challenge has been to develop universal biosensors with the flexibility to detect molecules regardless of their size antibodies have been used to fulfill this aim but singlestranded oligonucleotides aptamers interact efficiently with targets and have also been proposed as an alternative however aptamers lack the ability for versatile functionalization to tune affinities and they suffer from highly complex selection and identification chem2sense proposes an interdisciplinary approach to overcome these obstacles my hypothesis is that a new strategy based on the reversible conjugation of aptamers with small molecules will remove barriers in designing universal biosensors chem2sense aims to redesign the aptamer concept with flexible oligolegonucleotides and a cuttingedge nanopore sequencing methodology the two objectives will be to develop chemically modified nucleotides as legobricks to build highaffinity aptalegomers and to develop a groundbreaking sequencing methodology using artificial intelligence to boost aptalegomer identification the proposed legonucleotides are synthetic nucleotides that reversibly attach small molecules in a dynamic combinatorial library after challenging a vast library against a target a darwinian chemical selection will occur leading to the best fit the aptalegomer a highaffinity oligonucleotide of natural and conjugated legonucleotidestherefore the objective of chem2sense is to create a groundbreaking methodology that overcomes significant obstacles in aptamers development providing a powerful synergy between novel chemical aptalegomers generation and a direct method for selectionidentification using the latest advances in oligonucleotide sequencing chem2sense will bring highly sensitive and versatile aptalegomers to a broad range of vital applications
revealing the bacterial response to temperature and antibiotics stress via multiscale imaging

antibiotic resistance is one of the biggest scientific and health challenges of our time if actions are not taken antibiotics resistance infections will become the first cause of death by 2050 one of the most common signs of bacterial infection is a rapid increase of the host temperature that exposes bacteria to a heat shock hs to survive and quickly adapt to this new environment bacteria activate the synthesis of specific proteins called heat shock proteins hsps in ecoli hsps expression is mediated by the alternative sigma factor sigma32 sig32 the molecular processes that are associated with the bacterial stress responses induced by a combination of change in temperature and presence of antibiotics have not yet been investigated in detail due to the technical challenges of monitoring this combination of stresses with the necessary temporal and spatial accuracy celltocell fluctuations in protein expression could affect single cells survival therefore these processes should be studied with single cell precision i propose to investigate bacterial responses to the combined stresses of temperature increase and antibiotics at single cell level in live ecoli using a combination of microfluidics and single moleculesuperresolution imaging i will design and build a microfluid system able to control the stress landscape of temperature and antibiotic concentrations this will allow me to study sig32 expression during hs using fastmaturating fluorescent protein fusions next i will monitor how hs affects proteins synthesis by measuring the diffusion changes of single ribosomal subunits s30 and s50 during hs using single particle tracking palm finally i will quantify the interplay between hs response and antibiotic susceptibility by monitoring sig32 levels and the diffusion of ribosomal subunits taken together my results will provide for the first time a quantitative picture and a new framework to study bacterial response to multiple stresses
unlocking a t cellmediated immune response in therapychallenged tumors

immuno and targeted therapies have revolutionized the treatment of cancer patients and more innovative therapeutics such as kras inhibitors krasi are entering the clinic however their use as monotherapies fails to achieve durable tumor control in most patients and the development of combination therapies remains challenging without an understanding of the complex and dynamic biology that unfolds upon therapeutic challenge in the tumor microenvironment tme most of our knowledge on combination therapies is based on primary treatmentnave tumors but how signaling networks of cancer cells and their interactions with immune cells evolve under therapeutic challenge over time is poorly understood and strategies to overcome immuneevasive tmes are lacking here we build on our expertise in modeling the dynamic changes of cancer cells in all phases of therapy to move towardsstrategic mechanismbased combination therapies our vision is to unlock a t cellmediated immune response in therapychallenged tumors unlockit to achieve durable therapy responses in cancer patients 1 we will use our improved molecular time machine catchseq together with novel krasi and unique krasdriven tumor models to understand tumortme coevolution under krasi and related mechanisms of drugresistance 2 we will characterize mediators of antigen processing and presentation in treatment nave therapychallenged and immune evasive cancer cell states by using stateoftheart genomewide crisprcas9 screens in combination with innovative phenotypic readouts this approach offers a soughtafter opportunity to uncover mechanisms that make cancer cells visible to immunity 3 finally we aim to overcome immuneevasive tmes by understanding and targeting antigenpresenting cells in the tme taken together unlockit will provide new mechanistic links between oncogenic pathways and immunity and thereby establish a rational basis for combining targeted and immunotherapies
recyclable elastomeric plastics safely and sustainably designed and produced via enzymatic recycling of postconsumer waste streams

in the repurpose project local postconsumer waste is upcycled to new functional rep polymers targeting the highvalue market of thermoplastic elastomers that nowadays encounter recycling problems new building blocks derived from biomass or enzymatically degraded polyolefin or paper and cardboard waste will be incorporated giving the rep polymers unique features i tuneable elastomeric properties avoiding the need for additives ii production processing and recycling on existing equipment thus avoiding the need for huge capex investments iii controllable degradation in different habitats and iv unprecedented indefinite recycling outcompeting fossil carbon with every recycling step repurposes xfactor hence lies in the nonfossil content steering rep to higher value than the original plastic waste fractions the first biodegradable and recyclable elastomeric polycondensates in the world combining the functional strength with the leverage in ecology in higherend applications will create a considerable market traction when good marketing production and servicing are surrounding this innovative repurpose platform to enable this development the repurpose consortium is spanning the value chain from i waste handler recyclers and regulatory framework advocates over ii specialty bio or wastebased building block producers iii technology developers for rep polymerisation processing and detection to iv end users for consumer goods automotive and building and construction all advised by experts in safety and sustainabilitybydesign life cycle assessment business modelling and responsible research and innovation four universities and research centres a nonprofit organisation six smes including two startups from seven eu countries and the uk address the research challenges and pave the way for bringing the innovation to the broad public and creating a resilient and sustainable european plastics industry
multiscale investigation of mineral biosignatures with novel and integrated synchrotron approaches

microorganism are known to trigger or mediate the formation and transformation of different minerals such as carbonates and silicates microbialmineral interactions potentially generate chemical and structural characteristics in biominerals which can be preserved deep in time as mineral biosignatures and be explored in the search for life on early earth or mars we plan to investigate signatures of life in archean proterozoic and modern sedimentary structures by integrating chemical morphological and structural information using a pioneering approach based in laboratory and synchrotronbased advanced imaging methods our approach will integrate stateofart laboratory characterization of geochemistry and mineralogy with mineral and crystallographic textures and ultrastructure in 2d and 3d it will shed light into the understanding on the biomineralization processes of microbial carbonates and cherts and provide biological interpretations of relevance to studies on early life on earth and mars contexts
unravelling the behaviour of inorganic nanophases in leaves to optimize the foliar delivery of sustainable agrochemicals

population growth and the expectedtoincrease abiotic stresses due to climate change are putting the agroecosystems under pressure the dependence on inorganic agrochemicals ias for fertilization and plant protection will lead to an increase in their use yet current ias do not efficiently reach their target they lead to waste of resources pollutions and environmental degradations foliar application of nanostructures is one of the proposed solutions to optimize ias in order to better protect crops but also their agroecosystem nanoias can exhibit reduced leaf leaching and increased bioavailability allowing to strictly apply the right dose of ia however the lack of knowledge on ia behaviour at the leaf interface hinders our ability to predict optimized nanostructures the leaphy project aims to establish a rationale for the design of such nanoias model nanoias with controlled morphologies and surface properties will be designed and exposed to isolated plant cells or model leaves characterized for their surface characteristics and interfacial functional groups the pathways and associated rates of uptake transformations and in planta behaviour will be quantified these results will be used to establish a predictive modelling framework for the biological and chemical interactions that govern ia adhesion uptake and translocation from leaves to other plant tissues and organs this knowledge will be leveraged to design and test bio and geoinspired copperbased fertilizers and pesticides with improved delivery efficacy the teams expertise in tuning inorganic reactivity at plant interfaces and studying the resulting interactions and speciation changes is the backbone of leaphys stateoftheart experimental strategy this project will be a cornerstone in implementing solutions to contribute to building a rationale for safe foliar phytoprotection and fertilization strategies
composite material technology for nextgeneration marine vessel propellers

copropel puts forth a holistic approach towards the realisation of marine propellers made of advanced composite materials compared to their traditional counterparts marine composite propellers offer efficiency gains in propulsion efficiency noise reduction and weight savingsthe copropel project will see an interdisciplinary team of experts drawn both from research and industry from theoretical considerations and numerical modelling to precision manufacturing assembly and experimental verification testing the copropel action brings together 9 organisations from 5 countries 4 research institutes twi university of ioannina brunel university london and the bulgarian ship hydrodynamics centre 4 industrial partners loiretech meca danaos and glafcos marine with one certification body bureau veritas marine offshore together we will develop and bring to market a marine composite propeller with an embedded structural health monitoring system the proposed activities will mature our technology readiness level to 56 and drastically derisk the integration of the investigated solutions on future products effectively resulting in reducing the direct operating costs for the operators while minimising the environmental impactexisting work by the partners has shown an approximate 12 reduction in energy consumption and subsequent fuel consumption with the potential savings exceeding 15 at fullscale marine vessel propellers which will be investigated and confirmed during our realtime sea trials as part of the copropel project
critical raw material treatment and recovery from mining tailings and waste dumps

the characterization and cultivation of tailing dams and waste dumps for the treatment and subsequent recovery of critical raw materials is an actual priority concerning eu member statesthis activity is both linked to the purpose of the remediation of old mining sites for a new employment of the area and the soil reuse and to actually developing mining activitiesin this perspective the geophysical charaterization of tailing dams in order to organize the subsequent excavation and treatment activities is fundamental together with the social acceptance and the environmental impact evaluation of all the processaccording to the different kind of excavated materials and the related content of critical raw materials physical and chemical treatments may be proposed such as sieving magnetic and electric separation fluid media separation chemical andor biological leaching crystallization and precipitation solvent extraction membranebased processes or the integration of those all the performed operations must be evaluated according to environmental and economic aspects
bound to accelerate the rollout and expansion of energy communities and empower consumers as fullyfledged energy market players

with its clean energy for all europeans package cep the european commission formally recognised and instrumentally brought forward community energy projects including definitions for renewable energy communities recs and for citizen energy communities cecs the new concepts introduced in the cep set the course for a more active role of eu citizens in the energy markets to fully concretize the benefits envisioned by the cep a myriad of barriers needs to be overcome and progress needs to be done to clarify and streamline the concepts of rec and cec enabling its uptake by all interested citizensmotivated by that challenge communitas will promote energy citizenship enabling citizens to take control of their own path towards sustainability by becoming an active element of the energy markets the project will deliver a knowledge base that will provide users with technical administrative and legal information on ecs streamlining the creation and expansion of this concept communitas will also deliver an innovative set of tools capitalizing on technologies such as iot blockchain and cloud computing to unlock citizens active participation in energy markets and communities all integrated into an open digital onestopshop communitas core platform ccp allowing ec members to have an aggregated position in the energy markets or explore ancillary services using different energy assets or load profiles of the communityas a project that aims to position citizens in the centre of energy markets communitas has citizens at the centre of its own approach citizens will be involved in social and policy labs throughout the whole project in order to frequently factor in their feedback wishes needs into the core developments of the project
enhanced quantum resilience through twists

quantum technology will revolutionize information transmission processing and sensing with unprecedented potential for science economy and the society as a whole yet the strong sensitivity of quantum systems to unavoidable environmental noise impedes quantum technological breakthroughs here we propose to twist coupled elemental quantum systems such that they form a global robust quantum state that is resilient against environmental perturbations for instance in magnetic spin chains fixing the magnetization at one end while rotating the magnetization at the other end can result in stable quantum helices such quantum twists cannot easily be unwound they exhibit topological protection we want to explore the full potential of this concept and extend it to higherdimensional twists including vortices and skyrmions see fig 1 the main objectives of this project are to 1 theoretically describe quantum twists in chains and arrays of atoms 2 identify concrete realizations in cold atoms and solid state systems 3 supply a general theory for quantum twists and connect it to topological models in highenergy physics 4 designing and implementing an ontop errorreduction scheme for quantum information processing the presented approach is unrelated to known quantummechanical topological approaches in electronic and magnetic systems that rely on momentum space adiabatic manipulations or globally indistinguishable quantum states quantum twists can serve as a topological source of entanglement quantum energy storage and establish an independent and versatile noiseprotection mechanism for future quantum devices
smart eskins for lifelike soft robot perception

nature through millennia of evolution has endowed living organisms with unmatched sensory adaptability as robotics weave more deeply into the fabric of human society a compelling challenge emerges mimicking the sensory intelligence intrinsic to these life forms the intricate synergy between the organisms skin and brain delivering unrivalled sensory insight and data interpretation epitomises a domain in robotics still uncharted cultivating such perceptive sense in robots is crucial it heralds a future with enhanced safety and adaptability in humanrobot interactions revealing new horizons for innovative applicationsselect aims to bridge this perception gap in soft robotics a rapidly evolving robotic field inspired by the softness of living beings at the heart of select lies the ambition to pioneer smart electronic skins eskins that resonate with the sensory capability of organisms selects objectives include1 develop multimodal eskins for holistic perception2 build models to simulate the integration of eskins and robots3 explore automated adaptive eskin designs4 advance learning algorithms to decode eskin data5 streamline eskin deployment and trainingselects outcomes promise to redefine soft robot perception synergising eskin sensory attributes with stateoftheart machine learning beyond advancing robotics select envisions reshaping our interaction dynamics with intelligent systems championing a new epoch of humanmachine symbiosis