Dragon09/odtu_chatbot huggingface dataset:
supporting regional environmental sustainability assessment for the biobased sectors to improve innovation industries and inclusivity in south europe

the bioinsouth project aims to support decisionmakers to incorporate considerations of ecological limits into their regional bioeconomy strategies and roadmaps when it comes to circular biobased activities the project aims to develop guidelines and digital tools considering the safe and sustainable by design ssbd assessment framework to support the adoption of innovative methodologies to assess environmental impacts in multiple industrial biobased systems increasing regional competitiveness and innovation capacity and contributing to the eu fair green transitionthe project will focus on southern mediterranean european regions with particular attention to regions currently lagging behind ie regions in widening countries such as cyprus slovenia greece and portugal while the project will see the wider participation of other southern mediterranean countries including spain france and italy and international cooperation with turkey and argentina in the advisory boardthanks to the experience of the bioeast initiative that bioeast hub cz brings in bioinsouth will reach the main objective by establishing regional hubs bringing together a broad range of stakeholders including policymakers and public authorities expert voices market actors especially smes and civil society especially ngos the methodology will also seek the collaboration and exchange of best practices among the hubs within a macroregional bioinsouth network and with international organisationsthe concept will be demonstrated in 8 regions in the partners countries under a fully transferable casestudy approach that can be replicated throughout other southern european regions after the end of the project
the first nonclogging continuous flow reactor technology

flow chemistry represents a promising tool for the fine chemical and pharmaceutical industries to manufacture chemicals and drugsin a cheaper greener and safer way however current continuous flow systems present technical limitations especially regardinghandling solids and liquid viscous which have hindered their adoption by the industry today only 33 of the chemical processes canbe conducted in continuous flow systems due to solid particles that clog the process at qfluidics we have developed a breakthroughtechnology that overcomes the limitations of conventional flow systems our proprietary technology the liquid tube allows to handlesolids without clogging paving the way toward a wide range of chemical processes and enables process intensification making thistechnology ideal for industrial scale with the support of the eic we will industrialize our liquid tube flow reactors bringing to the marketmodular solutions for research and industrial scale applications
nonequilibrium field theory of molecular rotations

at the interface between chemistry and physics in this project we aim to develop a nonequilibrium fieldtheoretical approach to investigate molecular rotations in the presence of a manybody environment and driving laser fields unlike electrons or atoms molecules are extended objects with a rich internal structure and the possibility to perform rotations in compliance with the nontrivial algebra of quantized angular momentum a longstanding goal of chemical physics is the control of bimolecular reactions molecular reactivity strongly depends on the relative orientation of molecules which in turn is affected by the surrounding environment external laser pulses are applied to prepare the reactants in certain rotational states andor drive them to a specific alignments thus the interplay between external driving and dissipation due to the solvent is crucial for the quantum control of molecular rotations in this inherently outofequilibrium context we aim to develop a fieldtheoretical approach to describe molecules in bosonic and fermionic baths starting from diatomic molecules we aim to extend our theory to more complex structures and different shape and duration of the aligning laser pulses the project aims to pave the way for a highly innovative strategy to model dynamics of molecular systems and composite impurities based on quantum field theory in its nonequilibrium functional formulation
matching investors and eu funded innovations

the introduction of the innovation radar is a great step forward for bringing investors and innovations together however it is not enough as there still exists a lack of understanding between the investors and the innovators based on the innovation radar report there is a large gap where almost half of all innovations see access to finance as the main bottleneck for bringing their innovation to market currently investors lack information on new innovations coming from the research initiatives and researchers lack experience and access when it comes to reaching out to investors and scaling up their businesses the purpose of this csa and the mission of invest is to overcome this lack of information and bridge the gap between research projects and investors from both sides hereby significantly increasing the number of new ventures created from eufunded innovations to bring innovators and investors together and to reduce the information disparity it is crucial to leverage the innovation radar data and enrich it with third party data so that innovations and investors become able to find each other and have ways to put this information into perspective when possible ie benchmarking pattern finding comparing to make this connection successfully innovations need to be investor ready which will be accomplished through our targeted venture building and tech due diligence activitiesinvest brings europes leading startup data platform together with venture builders and tech dd service providers to create the ideal matchmaking platform that can bring a step change in the number of new ventures created
collective regulation of cell decisions

developing systems show an unmatched complexity due to an entangled regulation across different levels of organization errors in this regulation often lead to tissue and organ malformations and disease accordingly cell decisions like division fate or motility are not only guided by local signals generated at the cell microenvironment but also integrate cues propagated by collective properties at the tissuelevel such as tissue rigidity how the cells macroenvironment impacts cell decisions is still elusive largely because we lack methods and concepts to identify and eventually control collective tissue properties i will tackle this question by harnessing the physics of collective behaviours as design principles for synthetic in vivo developmental biology we build on our discovery that embryonic tissue rigidity emerges via phase transitions only when a simple cell parameter cell connectivity reaches a specific but generic value the critical point by identifying the responsible cell parameters and their critical points we will build tools to tune those parameters engineer for the first time a set of tissue physical properties in vivo and explore their role in cell decisions we will use the developing zebrafish as a model and quantitatively map cell parameters and the critical points at which tissue properties emerge control tissue properties by optogenetically tuning the responsible cell parameters in relation to the critical points dissect mechanisms of collective regulation of cell polarity and fate decisions at singlecell resolution derive generic principles of multiple cell decisionmaking by comparing species operating near or far from critical points uncovering how collective properties impact cell decisions will reveal mechanisms of tissue development transcending biological scales generate new hypotheses of how developing systems optimise biological functions and inform strategies for tissue engineering and disease treatment
developing sustainable solutions for viticulture through multiactor innovation targeting breeding for integrated pest management

according to the world economic forum and the european unions biodiversity strategy for 2030 biodiversity loss and ecosystem collapse are major threats facing humanity in the next decade massive consumption of chemical pesticides in agriculture is a significant contributing factor viticulture ranks high among the crops that depend on a massive consumption of chemical pesticides consuming approximately sixty percent of the fungicides applied in the eu making it a priority target for reducing the use of chemical plant protection products at the same time grapevine is economically and culturally important in the eu with wine being the largest eu agrifood sectorrecent advances and new perspectives in grapevine breeding have opened the possibility for grapebreed4ipm to address the reduction of fungicides and preserve biodiversity lessons learned from past experience in viticulture have shown that success in improving sustainability relies on global involvement of all actors therefore we brought together the top european research groups in grapevine breeding and involved different stakeholders along the grapevine industry value chain in a multiactor and codesign approach to produce the best insights for maximum impact the project will develop grapevine varieties with resistance to relevant diseases adapted to local environmental and pedoclimatic conditions and with the goal of reducing reliance on chemical pesticides in addition the project will provide farmers winegrowers and advisers with best practices and guidelines for integrated pest management adapted to diseaseresistant varieties as ingredients for their largest possible adoption and leading to a longawaited more environmentally friendly and sustainable viticulture in europe the projects outcomes will support evolution of the grapevine market to meet regulatory requirements and consumer expectations a market that is expected to reach nearly eur 204 billion by 2025
prognosis improvement of unprovoked venous thromboembolism using personalized anticoagulant therapy

venous thromboembolism vte is a frequent and lifethreatening disease in 50 of cases vte occurs in the absence of any major risk factors unprovoked vte in these patients when anticoagulation is stopped after 3 months of anticoagulation more than 35 will develop recurrent vte consequently international guidelines recommend to treat these patients indefinitely however such practice exposes them to a substantial increase risk of bleeding nevertheless after several years of anticoagulation in all patients with unprovoked vte the risk of anticoagulantrelated bleeding is expected to exceed the risk of recurrent vte after stopping treatment in addition extending anticoagulation indefinitely in all patients with unprovoked vte exposes 65 of patients to an unjustified high risk of bleeding who would never have experienced recurrent vte after stopping treatmentin this setting optimal duration and management of anticoagulation remains a pivotal and unresolved challenging issue which has the potential to markedly improve longterm prognosis of unprovoked vte based on quantitative and qualitative approaches morpheus will for the first time integrate i clinical laboratory and imaging biomarkers personalized medicine and ii socioanthropological markers patientcentred model into sets of prediction rules for optimizing anticoagulant management integrated in a shared decisionmaking process the ultimate goal of the european morpheus project will be to develop and validate a timedependent multicomponent tool integrated in a shared decisionmaking process regarding anticoagulant treatment duration in patients with unprovoked vte the whole morpheus program leaded by a consortium of outstanding european researchers in the field of vte will constitute a major breakthrough compared with the present standard of care in patients with unprovoked vte with major scientific public health economic and societal impacts
system for safe biological chemical radiological and nuclear assessment rescue and decontamination

emerging technologies on fast aerosolvapour sensors and fast and massive decontamination previously developed up to trl5 by participants of this proposal have demonstrated to be ideal candidates to provide universal fast and portable protection against cbrnthis project will mature these safe technologies and develop operational procedures for detection protection decontamination and assessment itself and will measure their effectiveness in experimental tests and practical demonstrations in operational environment trl7ex intrinsically safe cbrne aerial drone with sensors semiautonomous navigation even in denied gnss and automatic detection of victimstechnology and operating procedures for sheltering responders including vehicles against cbrne toxic clouds and aerosolsmass decontamination of infrastructures and vehicles tech procedures based on aerosol dynamic aggregationsensors and procedures for reliable assessment of cleanliness mass decontamination of people ie crowded arenadecontaminator of respiratory system of a victim or lung cleaneroperating procedures for safe cbrne debris removal and excavationadditionally after analysis of cbrne associated risks in rescue and recovery operations it will develop and validate an ai modular tool for generating operating procedures for first responders operating under a cbrne event these reliable useful tools and procedures at trl7 will substantially increase safety for all firstresponders either cbrn specialized nonspecialized and even rescuedogs minimizing the need to enter in a contaminated area and exposure of first responder and providing smart advice and fused information they haste a safe response and recovery reducing the number of victims and their severity as well as the environmental impact particularly crowded events will be safer against cbrn episodesintrinsic safety in explosive atmospheres is key to prevent catastrophic explosions with a terrific impact
a wearable electromagnetic interface for contactless environmental sensing with haptic feedback

insight will contribute to the new generation of electronic travel aids eta for visually impaired people by proposing the first augmented reality wearable electromagnetic haptic interface the interface will be designed entirely on a flexible substrate and integrated inside a glove replacing the actual generation of rigid bulky sensors it will include a radar an array of reconfigurable superdirective flexible antennas conformal to the body and a network of haptic actuators the superdirective antennas together with adhoc designed superresolution algorithm ie overcoming the radar sensor resolution will be proposed for an accurate sensing of the environment aimed at improving the navigation ability of visually impaired people the system will also allow to remotely feel the surrounding environment and objects shape the haptic actuators located inside the glove will be used to convey a contactless tactile sensation to the user a solid phantom of the human hand will be used to experimentally test the exposure and device performance for multiple conditions and realistic scenariosthis proposal is perfectly in line with the research priorities of the eu since it aims to boost the innovation in digital technologies and wearable electronics while facilitating the integration of visually impaired people in the society and significantly improving their independence insight is an intrinsically interdisciplinary and intersectoral project involving antenna design radar signal processing bioelectromagnetics and haptics this fellowship will be carried out at universit de rennes 1ietr fr thanks to the unique available know how in flexible antennas microelectronics and bioelectromagnetics under supervision of prof r sauleau a secondment 4 months is also planned in the rogers research group northwestern university usa under supervision of professor j a rogers worldwide expert in wearable and flexible biosensors
currentfree stellarator for fusion power plants

a currentfree stellarator is a type of magnetic confinement device that confines a hot ionized gas in a toroidal vacuum vessel with external magnetic field coils if the gas is sufficiently hot hydrogen isotopes fuse to helium cores and neutrons releasing a total of 176 mev energy per reaction as neutrons are not confined by the magnetic field they deposit their energy in an actively cooled wall this drives a standard heat cycle with a turbine to generate electricity a mature technology proxima fusion is already working on an integrated modeling framework to deliver a reactor relevant and costcompetitive configuration based on the concept of a currentfree stellarator by informing the modeling framework of engineering constraints and vice versa proxima fusion can ensure that their engineering design based on the optimized configuration can be built while massively decreasing expected manufacturing costs due to optimization for higher error tolerance
environment research infrastructures innovation roadmap

envrinnov will codesign test and validate a common innovation roadmap for the european environmental and earth system research infrastructures envri community this roadmap will set a credible pathway for the envri community to establish and operate an envri innovation hub eih for the future development of new stateoftheart technologies and services the project will also develop the tools policies and community necessary for the roadmaps successful implementation to achieve this envrinnov will i conduct a comprehensive analysis of envri services and technological needs gaps and define how to monitor them regularly ii define digitalize and promote the uptake of common envri innovation strategies for new technologiesservices development to meet emerging needsgaps this will be done by defining and testing innovation cocreation mechanisms between envris industry and the scientific community and shaping them into common policies the project will also develop an envri innovation capacitybuilding programme a digital platform to enable them and an uptake strategy to promote them iii engage the esfri and ri environment ecosystems to ensure longterm synergies and complementarities with envri and gather feedback and support for the roadmap finally the project will plan for the timely and realistic implementation of the roadmap by also creating and validating with the envri community an implementation plan governance model and business model for the eih envrinnovs approach supports esfris strategic objective to accelerate the exploitation of eu ris as knowledge innovation hubs it will help strengthen the european response to the climate crisis and its associated scientific societal and economic challenges by increasing the capacity of envris to respond to them it will contribute to a more effective eu ri landscape and support better integration across thematic areas and with the eu technology infrastructure landscape
bioprotect balloon implant system enabling safe prostate radiation treatment even at extreme dosage

prostate is the 2nd leading cancer in men in the world with more than 14 million men diagnosed every year globally 50 of men will be treated with radiation treatment radiation is a highly effective treatment however it has significant complications mainly injuring the rectal tissue approximate to the prostate treatment area up to 35 of the patients will experience rectal toxicity side effects such as bleeding urinary bowl and erectile dysfunction damaging severely patients quality of life there is a growing need for a solution that protects the rectum from the radiation field our soluton prospace is a biodegradable medical grade copolymer 7030 poly llactidecocaprolactone balloon spacer deployed in the prostaterectum interspace it creates a 18cm symmetric distance between the prostate rectum allowing physicians to radiate prostate tumours sparing healthy rectal tissue
enzyme immobilization for enhanced transdermal penetration of bioactive compounds for treating skin diseases

the use of natural bioactive compounds nbcs in dermatological treatment is a promising healthcare frontier however their effectiveness is hindered by limitations in skin penetration enhancing their delivery to target skin layers or specific disease sites remains a significant challenge encapsulation of nbcs within nanodispersions nds and their embedding in a biopolymer hydrogel matrix has demonstrated promising outcomes in terms of improving the delivery of nbcs through the skin however theres still a need for more significant enhancement in penetration while the reasons behind this effect remain uncertain this project aims to overcome these challenges through the immobilization of enzymes like hyaluronidase that breaks down hyaluronic acid major skin component within the biopolymer hydrogel matrix by prioritizing enzyme immobilization as a catalyst for enhanced penetration this project pushes the boundaries beyond traditional encapsulation methods this project plans to extract bioactive compounds from natural sources and investigate effective biocompatible encapsulation methods additionally it will assess the biopolymer hydrogel matrix where the developed nds and enzymes will be incorporated and immobilized the equilibrium of the immobilized enzyme will be carefully studied to achieve optimal association and dissociation aiming to enhance transdermal delivery while maintaining skin health moreover comprehensive bioavailability and cytotoxicity studies as well as in vitro and ex vivo analyses for in depth characterization of the transdermal delivery of nbcs are planned by merging biocatalysis and nanomaterials this project offers a more effective alternative to conventional treatments including skin cancer minimizing the ecological impact
interplay of cmv with cellular pathways states and cell types

the herpesvirus human cytomegalovirus hcmv the largest known human virus is a ubiquitous pathogen that infects the majority of the worlds population although subclinical in most healthy individuals hcmv can lead to a severe congenital disease as well as morbidity and mortality in immunocompromised adults despite the high prevalence and pathogenicity of hcmv numerous fundamental questions about this pathogen remain open we still do not know what many of its viral proteins do and how they modulate cellular processes we do not understand the determinants that govern dependencies and vulnerabilities of infection in different cell types and we are missing tools that facilitate molecular dissection of hcmv in relevant infection modelsin this proposal we plan to develop and apply unique tool sets to uncover the host pathways and factors that orchestrate hcmv life cycle in different cell types and in higher complexity infection models we propose to combine stateoftheart highthroughput tools with mechanistic studies to comprehensively characterize how hcmv proteins perturb central host cellular processes aim 1 identify hcmv common and cellspecific host dependencies and vulnerabilities in different cell types aim 2 and develop an advanced platform for probing cmv dependencies in organoid and organism infection models aim 3 the knowledge generated from these objectives will provide a comprehensive depiction of the interplay of hcmv with its host and could help expand our therapeutic options more broadly with its comprehensive and complementary approaches our work will provide a paradigm for understanding complex hostpathogen interactions