Dragon09/odtu_chatbot huggingface dataset:
migrations of textual and scribal traditions via largescale computational analysis of medieval manuscripts in hebrew script

midrash aims to construct a groundbreaking interdisciplinary methodology for a global approach to the study of the treasure trove of medieval literary manuscripts in hebrew script jews produced and consumed a prodigious cornucopia of texts in hebrew aramaic judeoarabic and other vernacular languages intertextually closely related like a mille feuille the manuscripts constitute the unique remains of medieval jewish literary culture having survived and witnessing to centuries of migrations persecutions and censorship with the recent digitization of the extant manuscripts and with contemporary advances in computer vision natural language processing and machine learning the time is ripe for broad new studies into this manuscript culture we can now study questions regarding their materiality textuality transmission and historical contexts on an unprecedented scale or heretofore beyond reachmidrash proposes a pioneering study of the extensive corpora of 1 biblical manuscripts 2 midrash late antique exegetical and homiletical commentary on the bible 3 medieval commentaries of the bible and mishnah and 4 liturgical manuscripts only a small fraction have been transcribed let alone studied stateoftheart and bespoke algorithms will be applied to resolve issues of reading order code switching and transcription errors once mechanically transcribed known and unknown works will be identified and reconstructed and multilingual intertextualities discerned the latest finegrained paleographical techniques and trained neural networks will be brought to bear on questions of provenance and transmission philological methods and computational linguistics will be applied to questions of textual fluidity and evolution to further our knowledge of the production and transmission of hebrew manuscripts and texts their authors scribes and readers and enhance their role as the pivotal aspect of european and mediterranean intellectual history
desynchronizing weak cortical fields during deep brain stimulation

deep brain stimulation dbs is a surgical treatment for parkinsons disease and other neurological disorders by applying pulsed alternating electric currents to targets deep in the brain dbs induces widespread changes in neural network activity although motor symptoms can be reduced by dbs in most patients some patients suffer from severe side effects or insufficient symptom reliefmany attempts have been made to optimize the therapeutic effects of dbs but these attempts have been restricted by a lack of understanding of how dbs exerts its therapeutic effects various therapeutic mechanisms have been proposed but none have fully explained all of the complex effects of dbs these theories have focused on direct and indirect effects of the strong electric fields near the stimulation contacti propose a radically new hypothesis on the therapeutic mechanism of dbs that harnesses current insights from noninvasive brain stimulation weak electric fields during noninvasive brain stimulation have recently been shown to desynchronize neural activity from the surrounding network activity i suggest that weak electric fields during dbs desynchronize cortical activity which can in combination with the effects of strong subcortical electric fields reduce pathological synchrony in motor system networks and thereby restore motor controldecode will integrate largescale volume conduction modeling to estimate and steer personalized electric fields biophysical neural network modeling to understand the physiological consequences of weak fields and their interaction with strong field effects and eeg measurements in humans to verify these models finally based on the obtained knowledge and computational tools decode will clinically test the hypothesis in patients with parkinsons disease if successful decode will start a new era in our understanding of the therapeutic network mechanisms of dbs and trigger clinical breakthroughs to optimize dbs therapy
foodcost food costing and internalisation of externalities for system transition

ensuring sustainable food systems requires vastly reducing its environmental and health costs while making healthy and sustainable food affordable to all in current food systems many of the costs of harmful foods and benefits of healthful foods are externalized ie are not reflected in market prices and therefore not in decision making of actors in food value chains solving the externality problems means to determine current costs of externalities and redefine food prices true pricing to internalize them in daily practice policy makers businesses and other actors in the food system lack sufficient information and knowledge to internalize externalities to achieve a sustainable food system foodcost responds to this challenge by designing a roadmap for effective and sustainable strategies to assess and internalise food externalities foodcost provides approaches and databases to measure and value positive and negative externalities proposing a gamechanging and harmonised approach to calculate the value of climate biodiversity environmental social and health externalities along the food value chain based on economic cost principles foodcost provides an analytical toolbox to experiment analyse and navigate the internalisation of externalities through policies and business strategies providing tools and guidance to policy makers and businesses to assess the sustainability impact of their internalisation actions foodcost emphasises the diversity of challenges of true pricing in different value chains and countries and regions and cocreates tests and validates the valuation and internalisation approaches in 11 diverse case studies enabling to test validate and enrich the approaches in order to transit towards a sustainable food system the project will be based on a multiactor approach that will ensure a continuous dialogue with all relevant actors across the whole food system land and sea
functionalized graphene based electrode material for lithium sulfur batteries

fungrab project addresses the pressing need for ecofriendly sustainable and rechargeable batteries with high capacity energy density and long lifespan which will significantly expand the energy storage marketwith the rapid development and broad application of mobile devices electric and unmanned vehicles as well as with the rise of smart grids and networks for the internet of things the demand for batteries with higher performance lower cost and lower environmental burden is rapidly growing in order to address the aforementioned challenges various strategies emerged over the past few years for the development of advanced composite cathodes designed for high sulfur utilization and stability in particular the pinning of sulfur is pursued by engineering materials as highaffinity hosts for sulfur to hinder the shuttling of lithium polysulfidesfungrab project aims to deliver the upscaling of an industriallyrelevant onestep novel manufacturing process for a lithiumsulfur batteries electrode material enabling a significant boost in the cycling stability without sacrificing its performance ie capacity this will be achieved through the implementation of costeffective materials and processes along with taking our technology readiness level from 2 to 4 thus shaping a significant business opportunity enabling us to continue development within an eic transition project
a sonar sensing system for crop yield estimation

with the rapidly growing world population accelerated climate changes and global migration nutritional security is a major challenge this situation calls for fast development and utilisation of agricultural technology that will push agricultural yield production to its full potentialyield estimation in agricultural production is thus central for both agricultural planning as well as for successful agroeconomic management despite its importance agricultural yield estimation is currently almost solely done manually without assisting technology and it is therefore inaccurate and limited to small areas to meet this challenge we offer a unique sonar sensing system for largescale rapid yield estimation our technology as demonstrated in a recent peer reviewed paper and in additional preliminary studies has unexampled advantages compared to other sensors the sonarbased crop estimating sensor has been patented and initial tests show that it is capable of estimating pepper and tomato yields with 90 accuracy under laboratory conditions the technology has several advantages over pursued optical based solutions including the ability to penetrate the vegetation and its functionality under all lighting conditions in the proposed project we will expand those tests to additional key vegetables eg cucumbers and elaborate our approach to make it functional under field conditions aiming to provide farmers with a reliable tool for crop estimation our team is composed of sonar agriculture robotics and business experts covering all of the needs of the project we will collaborate with agrirobotics companies and agricultural stakeholders in the eu to fulfil the goals of our poc project the project will ultimately lead to the necessary steps for establishing a spinoff company that will exploit this invention and provide a product to the benefit of european and worldwide farmers
onchip model of mucociliary clearance for the design of drug formulations aimed at chronic respiratory diseases

chronic respiratory diseases crds caused 4 million deaths worldwide in 2019 crd treatments are often administered by inhalation in particulate formulations however mucociliary clearance mcc acts as an effective physical barrier that prevents drugs from reaching the target cells this mechanism relies on the beating of cilia on the bronchi surface which allows the displacement of the overlying mucus layer inhaled drugs are thus trapped by the mucus and quickly evacuated from the airwaysthe objective of the must project is to model the mechanism of mcc using a microfluidic chip to assess drug penetration through the moving mucus and thus provide a screening platform for new drug formulations our main objective can be subdivided into three research objectives 1 develop an adequate synthetic mucus model 2 reproduce the mucociliary clearance mechanism on a microfluidic chip 3 screen innovative drug formulations using our chipin this project we combine expertise in biophysics physical chemistry soft condensed matter and nanomedicine the originality of our approach lies in 3 key aspects 1 we will develop a synthetic mucus model that reproduces all the properties of native human mucus 2 we choose to design a noncellular mcc model which will provide an easy quick cheap and reproducible alternative to cellbased mcc models 3 we will apply an original technique called differential dynamic microscopy ddm to characterize the drug behaviour in the chip ddm is perfectly adapted to measure particle diffusion in biological hydrogels under flowing conditionsour innovative screening platform will pave the way to design more efficient formulations to treat crds with higher delivery rates thereby improving the available treatments and lowering their costs this project is in line with the united nations aim to reduce by 2030 by onethird premature mortality from noncommunicable diseases including crds through prevention and treatment
force production of myosin 18 and its molecular sociology with myosin 2

the cytoskeleton is a complex protein web organised through the cell to provide structure and cell shape dynamics one critical and often overlooked component is myo18 which is part of the myosin superfamily of motor proteins by interacting with actin myosins canonically produce force through a series of conformational changes driven by the hydrolysis of atp however myo18 appears not to cycle through the set of conformations found for other myosins due to its divergent sequence it is therefore hypothesised to act as an actin crosslinker rather than actively producing force another myosin family myo2 is the most prominent force producing component in the muscle sarcomere and in stress fibres which drive cell migration myo2 performs its role by forming filaments through a coiled coil domain creating a structure with multiple force producing heads ready to bind and move along actin the coiled coil of myo18 allows recruitment into myo2 filaments within these niches but its role is obscure given its divergent behaviour the sociology between these two myosin families that is the specific interactions of different partners in space and time is interesting given the complementary features of these two protein families this study aims to structurally characterise myo18 in different nucleotide states on and off actin to gain insights into the evolution and function of its cryptic cycle furthermore this work will assess through structural characterisation how myo18 and myo2 directly interact through their coiled coil domains this association will then be analysed through biophysical studies exploring how myo18 alters force production and function by intercalating into myo2 filaments
support stakeholders on carbon capture utilisation and storage of etip zep and iwg9

support stakeholders on carbon capture utilisation and storage of etip zep and iwg9the overarching goal of this proposal is to bring together and further develop a strong inclusive network of ccus stakeholders effectively interconnecting and coordinating the activities of ccus european technology innovation platforms etip zep and the ccus set plan implementation plan working group iwg9 to support the development and implementation of the set plansupporting the alignment and efficient coordination of stakeholders including industry researchers public authorities civil society in order to accelerate the delivery of the ccus research and innovation ri activities and to progress the emerging policy priorities at eu and national level for the implementation of ccus will be crucial over the coming years for europe to reach the ambitious climate targets for 2030 and 2050this will be achieved by efficiently aligning and coordinating the activities of etip zep and the iwg9 in a joint work programme establishing networks and other fora to enable the stakeholders to collaborate and coordinate effectively pooling expertise experience and resources to address common challenges engaging also with other programmes and external stakeholders facilitating engagement and creating greater interaction and cohesion between the different ccus activities supporting the ccus community to develop clear strategies and recommendations accompanied by a strong continuous programme for outreach dissemination and communication
deciphering the microglianeuron interactions in human alzheimers disease

the goal of this project is to decipher the exact cellular and molecular mechanisms by which human microglia transduce toxicity to neurons in alzheimers disease ad genetics revealed that microglia are one of the central players in the pathogenesis of ad i and others have characterized the phenotypic response of microglia in ad using transcriptomic and epigenetic tools nevertheless it is yet to be defined how microglia communicate with other cells in the brain by which mechanism they lead to neuronal alterations and what the particular role of different microglial activation states is in this process i will investigate the two major functional outputs of microglia namely physical interaction with synapses and release of inflammatory factors that induce neuronal dysfunction and degeneration in ad determining the role of human microglia in ad comes with technical challenges including lack of homology between mouse and humans and limited expression of ad risk genes in mouse microglia i will use a human microglia xenograft model i pioneered where ipscderived cells are transplanted into the mouse brain and in which they adopt a brain resident phenotype and can be exposed to amyloidb plaques i plan to combine xenotransplantation of genetically engineered ipscderived microglia and neurons with stateoftheart strategies to define the human microgliasynapse protein interactome as well as the cellspecific proteomesecretome i aim to 1 define the surface protein interactome between human microglia and mouse synapses in vivo 2 cotransplant human microglia and human neurons in the mouse brain to explore human to human specific aspects of this interaction and 3 investigate the human microglia specific secretome in ad this project will be the first of its kind to directly study the role of human microglia in the ad brain at cellular and molecular levels opening new avenues for the development of new therapeutics and biomarkers to tackle disease
proving causality of liquidliquid phase separation for the acquisition of nuclearlike functions by giant viruses viral factories

giant viruses gvs encode thousands of orfan genes but their study has been nearly impossible due to the lack of genetic tools for reverse genetics the aims of vidama and the tools i designed will shed light into this viral protein dark matter particularly i will study how new genes from mimivirus were engineered during evolution to acquire nuclearlike function for their viral factories vfs vfs physically separate viral dna replication and transcription from translation and likely segregate dna into active and silent how these functions are accomplished remains elusivei will demonstrate causality of liquidliquid phase separation llps for the acquisition of nuclearlike functions of the viral factories vfs of mimivirus to do so i will1 generate genomewide lossoffunction screens for the identification of gene function and proteomewide localization of virtually all mimivirus and its host acanthamoeba proteins2 combine biochemistry and cell biology to dissect the nature functions and components of the vfs of mimivirus 3 strip down vfs to their minimal components in order to utilize them to improve production efficiency and purity of mrna during in vitro transcription vidama will empower the gvs scientific community with genomewide and proteomewide data of gene function and protein localization it will transform the field from mostly descriptive to allow the dissection of the molecular mechanisms behind viral phenotypes vidama will also address the molecular mechanisms that allow the vfs to acquire nuclearlike functions directly tackling the viral eukaryogenesis theory the new classification of vfs as membraneless organelles and the study of the molecular mechanism behind their biogenesis and functions will shed light into general mechanism of llps the generation of in vitro vfs promises an optimization of in vitro transcription systems with tremendous impact on mrna therapeutics at the development and production level
social innovation responsive environments network

the main aim of the sirene proposal is to support the growth of social innovation ecosystems delivering ecofriendly and sustainable communitybased services for shafe smart healthy agefriendly environments implementation in europe by providing a workable framework for investment and the broad adoption of highquality smart living solutions combining the housing sector and ict infrastructurethere have been several initiatives and previous csas aiming to promote innovation and support stakeholders to increase investments in relevant societal areas often providing support measures to different actors such as webinars trainings workshops twinnings however their impact usually runs shorter than desirable in the mid and longterm sirene identifies a diverse approach connect stakeholders by having them working together towards a social innovation framework and supporting tools claiming that this joint collaborative and cocreative work will increase awareness of innovation actors on social innovation concepts methods and he skills to leverage them make social entrepreneurs aware of potential business opportunities funding and investment around shafe create alliances and synergies between different stakeholders within ecosystems and between ecosystems ensure that business actors have access to social innovation and entrepreneurial knowledge unleash the potential of social innovation ecosystems on shafethe desired impact of the sirene proposal is to improve the wellbeing and housing conditions of the european population by empowering social and private entrepreneurs sirene leverages on the networks and outcomes of the shafe network and the cost action19136 net4agefriendly shine and afe coordination the ectp and homes4life tecnalia the thematic inovation ecosystem on housing and health echa and israa as well as the european reference framework on smart agefriendly housing the green deal and h2020he ict funded projects
personalised medicine empowerment connecting innovation ecosystems across europe

the general purpose of preciseu is connecting innovation ecosystems across europe to efficiently advance towards a truly personalised healthcare transferring practices and solutions from region to region and scaling up deeptech healthcare innovations based on advanced therapies medicinal products and health data across europe the preciseu consortium is composed of regional authorities and innovation players from 9 nuts 1 and 2 regions supported by clusters universities research centres and infrastructures ngos and networks and engaging regional and european innovators scientists and entrepreneurs across the eu health innovation space also involved as partner in the consortium one ukrainian region rivne represented by the rivne medical cluster has a relevant role as ukraine is open for cooperation innovation and joint projects for reconstructionthe european continent faces a set of challenges in terms of the swift and effective implementation of medical care which were brought sharply into focus during the covid19 pandemic healthcare remains a concurrent gap between innovation leaders and emerging and moderate innovators classification according to the regional innovation scoreboard ris which impacts all spheres economics social and living standards and which requires significant expertise and knowledge as well as expansive collaboration between innovation networks and all stakeholders and communities across europe preciseu is aware that taking next steps in the development and organisation of pm is a key issue for europe and that more coordination efforts between key european stakeholders is necessary to foster its implementation by focusing on health data and advanced therapies as key drivers of personalized medicine models preciseu will not only provide regional ecosystems with european connectivity but will most importantly address the significant and urgent needs of the regions
mera ethical accurate drug development

using patented fluid management technologies the mera system has the ability to culture drug stain 3d tissues on a large scale while monitoring everything in real time through a fully automated florescent microscope 3d microtissues are added to a dedicated consumable bioplate the plate is then integrated into the main mera system a chemical cocktail can be introduced to selected wells on a plate in order to mature the cells into different tissue types such as liver heart neuronal or cancer the fluid pathway can be changed to allow the introduction of a drug or stain to batches of multiple different tissue types the fluid can then be recirculated replicating the conditions in the human body where organs interact with each other the whole process can be monitored using the automated microscope in wide field or florescent modes the system is modular scalable allowing a single unit to run up to 800 microtissues simultaneously