Dragon09/odtu_chatbot huggingface dataset:
understanding material synthesis conditions and complexity at highpressure

functional materials with outstanding technological properties can be found under extreme pressures and temperatures this is particularly true for nitrides and hydrides where the application of highpressure hightemperature hpht conditions has recently revealed an unexpectedly rich and complex chemistry and enabled the synthesis of compounds showing outstanding mechanical and electronic properties with applications in electronics hard coatings hydrogen storage superconductivity and many more however great challenges remain to be conquered in order to truly explore the possibilities permitted by these exotic materials indeed their properties often vanish when brought back to ambient conditions either because the atomic arrangement or the underlying physical processes becomes energetically unfavourable moreover the importance of finitet effects and the structural and dynamical complexity of these hpht phases prohibit computations so far from efficiently guiding experimental synthesisthe goal of this project is to provide the computational tools for guiding the efficient and targeted synthesis of nextgeneration technological materials including the choice of synthesis conditions and precursor materials we will search for materials retaining their functional properties under decompression or are directly synthesizable at ambient pressure to accomplish this we will develop a work flow based on machine learning interatomic potentials to numerically explore experimental synthesis conditions at abinitio accuracy this will enable an analysis of thermodynamic competition between different phases at hpht and rigorous benchmarking against experiments to ensure that we truly portray natures behaviourthis project will open up uncharted horizons for exploiting pressure and temperature as thermodynamic variables to explore new chemistry and synthesis pathways ultimately guiding experiments towards industrially relevant novel technological materials
improving qmri by realizing trustworthy integration of ai in neuroimaging

mri is a key methodology in modern neuroimaging but conventional mri relies on visual interpretation of intensity differences in the images which is heavily dependent on scanner settings quantitative mri qmri is an attractive alternative mri method that allows quantitative measurement of physical tissue parameters enabling objective comparison between patients and across time moreover qmri facilitates early detection of pathological changes in the brain resulting from neurological disorders such as multiple sclerosis unfortunately and despite the demonstrated potential in research settings the implementation of qmri in routine clinical practice remains limited due to long scan and postprocessing times while recent developments in artificial intelligence have the potential to accelerate and improve medical imaging pipelines reduced transparency about the underlying processes the lack of training data sets and limited information about the accuracy of the results has limited its use for clinical qmri applications so farin iqbrain we propose a unique research and training programme that tackles this urgent need for improved and accelerated qmri methodology for neuroimaging applications by integrating both physicsbased models and trustworthy artificial intelligence methods along the qmri pipeline our innovative approach combines the best of both worlds iqbrain will prepare the next generation of qmri specialists trained in the different aspects of the qmrineuroimaging pipeline that can bridge the gap between qmri method development and clinical need through a training programme of networkwide events international secondments and strong interaction between partners from academia industry and hospitals iqbrain offers earlystage researchers a rich combination of knowledge expertise and essential transferable skills that prepares them for a thriving career as rd professionals in the qmri field
investigating virushost interplay in human primary models of genetically modified respiratory epithelium

respiratory viruses can rapidly spread worldwide with a devastating impact as dramatically highlighted by the covid19 pandemic in addition to the pandemic threat posed by influenza a viruses iav or coronaviruses respiratory viruses including iav influenza b virus ibv seasonal coronaviruses and respiratory syncytial virus rsv are the cause of yearly epidemics with a huge impact on human health the vast majority of in vitro studies has been performed with model cancer cell lines however they share limited features with the primary cells found within the human respiratory epithelium robust and relevant ex vivo models of human primary airway epithelia cultured at the airliquid interface ali have been developed over the years and nicely recapitulate the structure and composition of the in vivo respiratory epithelium nevertheless in depth studies on the genes and the potent innate immune interferon ifninduced defences regulating viral replication in such pertinent models are still lacking the invirium project will address this knowledge gap by combining a newly acquired expertise in the generation and gene editing of human ali airway epithelia with a strong expertise in crispr screens and virology the objectives of invirium will be to explore in depth the relationships between major human respiratory viruses sarscov2 iav ibv and rsv and their relevant primary target cells invirium will characterize the ifnstimulatedgenes responsible for the potent antiviral state explore the mechanisms of sarscov2 escape from the ifn system and define the landscape of host genes regulating respiratory virus infection in this physiologically relevant ali model invirium will bring a change of paradigm in the way we study respiratory viruses by implementing cuttingedge approaches in highly pertinent human models and will gather fundamental knowledge that is currently lacking on the interactions between viruses and their primary target cells
nanoscale organization and dynamics of ermitochondria contact sites upon induction of synaptic plasticity

the endoplasmic reticulum er can rapidly reorganize its functional domains and interorganelle communication sites in response to cellular demands ermitochondria communication is essential for normal cell physiology as it conveys lipid exchange mitochondrial calcium uptake among other vital processes for mitochondrial function in neurons activitymediated dynamics of er and mitochondria are required for synaptic responsiveness to induction of synaptic plasticity and stimulating neuronal activity increases the number of ermitochondria contact sites ermcss whilst system modelling predicts that ermcss control the postsynaptic energy landscape the actual contribution of synaptic and perisynaptic interorganelle dynamics to synaptic plasticity is still quite unknownthe small and compact structure of dendrites constrains the visualization of local ermitochondria contact site dynamics being the application of nanoscopy techniques fundamental to follow these processes upon induction of synaptic plasticity the use of cuttingedge superresolution microscopy in this project will provide unprecedented spatiotemporal resolution to the study of activitymediated er and mitochondria dynamics and interorganelle contacts heterogeneity in live neurons likewise it will clarify the contribution of ermcss to sustain normal dendritic physiology as well as the intricate system triggering and upholding synaptic plasticity dysfunction of the ermcss has been reported in various neurodegenerative disorders due to mutation in proteins promoting and supporting ermitochondria communication neurodegenerative disorders are responsible for a great burden in disease as dementias alone affect over 7 million people in europe and this figure is expected to increase dramatically with aging of the population
complex exciton dynamics in materials a firstprinciples computational approach

understanding the energetics and dynamics of excited states formed by lightmatter interactions is essential for applications across optoelectronics and photophysics in systems of reduced dimensionality stronglybound excitons serve as the main energy carriers with long diffusion and relaxation lifetimes as exciton dynamics are coupled to optical selection rules that stem from the atomic structure enhanced exciton transport efficiency can be achieved through local structural modifications such as atomic impurities and interface design as well as crystal fluctuations yet current theories lack a predictive description of the underlying interactions due to such structural modifications highlighting the need for new tools that can capture these complex exciton dynamicstaking advantage of evergrowing computational frontiers in this erc project we will derive and apply a new theoretical approach based on the predictive manybody perturbation theory to compute exciton dynamics as a function of structural complexity in emerging materials we will derive and examine our approach on three emerging excitonic systems of reduced dimensionality organic molecular crystals layered transition metal dichalcogenides and twodimensional hybrid perovskites obji as proofofconcept we will use our theory to study the effect of atomic defects and heterostructure compositions objii as well as lattice fluctuations objiii on the mechanisms dominating exciton relaxation and diffusion and their resulting mobility and lifetimeour research will thus allow for a comprehensive and predictive understanding of the underlying physics dominating exciton decay processes in materials of emerging interest via frontline computations offering novel and tunable design principles for optimized functionality
medical electricity embodied experiences and knowledge construction in europe and the atlantic world c17401840

scientific knowledge has long been understood to be subjective and situated elbow examines this situatedness from a previously unexplored historical viewpoint by investigating the role of lay embodied experiences in eighteenthcentury scientific knowledge construction the project starts from the premise that knowledge is necessarily filtered through individuals embodied cognition and therefore tactile sensory and experiential using eighteenthcentury medical electricity as an empirical case study the project analyses how patients embodied and experiential knowledge influenced the medical knowledge emerging from electrotherapies as well as whose experiences and ways of knowing ended up contributing to scientific knowledge as a novel experimental therapy medical electricity provides an exceptional window into practices of knowledge construction authorisation and marginalisation since electrical treatments and the bodily sensations they created were meticulously recorded by doctors and patients alike these descriptions can be analysed as repositories of experiences and understandings of embodiment as well as epistemological beliefs regarding body life and matter medical electricity offers the perfect vantage point for examining popular epistemological understandings their interaction with scientific epistemologies and the way they manifested themselves in electrotherapeutic practices elbow devises an innovative methodological approach to tease out patients embodied experiences and epistemological beliefs from a variety of sources including scientific treatises doctors casebooks advertisements fiction and egodocuments combining phenomenology and cognitive science with history of medicine methods the project proposes a new theoretically sophisticated approach to analysing historical everyday experiences and embodied knowledgeand thereby a turn towards a new experiential paradigm in history of knowledge
moonlighting understanding the quality and consequences of working multiple jobs

moonlight is a transdisciplinary and multimethod study of the quality of work and wellbeing of contemporary multiple jobholders working in the new economy is increasingly of a flexible and fragmented nature moonlighters or multiple jobholders mjhs can be considered emblematic of how work fragmentation and combinations affect the quality of work and total worker wellbeing moonlight will research the quality of work in first second and other jobs and how this translates into total worker wellbeing i introduce this concept of total worker wellbeing to refer to the complex interdependencies and coexistence of features this is both conceptually and empirically groundbreaking as conceptual research and the development of comprehensive scales on wellbeing at work is still in its infancy and its inclusion enables researchers to make meaningful comparisons between groups of workers both single and multiple jobholders apart from this conceptually innovative part a unique and crucial feature of this programmes empirical approach is its innovative app for dynamic quality and wellbeing assessment moonlight will study the quality and wellbeing of mjhs through comparative research in seven advanced economies denmark germany italy the netherlands poland the united kingdom and the united states even though the meso and macrolevel contexts both have a pivotal role in the prevalence quality and wellbeing of mjhs these levels have so far rarely featured in research a void this programme aims to fill all countries have increasing levels of mjhs but with different welfare state traditions regulations and policies norms and labour markets by researching the practices used to conceptualise classify and measure quality of work and wellbeing and translating these into a futureproof conceptual framework and app that capture the complexities of the modern fragmented world of work moonlight will provide both theoretical and methodological advancement
urban logistics and planning anticipating urban freight generation and demand including digitalisation of urban freight

unchain will break the chains boosting the cooperation between public authorities and logistics stakeholders it will create a set of services for optimal and flexible urban logistics operation management planning and policymaking unleashing the potential that technology and digitalisation can bring to the sustainable urban logistics and moving towards climateneutral and smart cities unchain will implement a standardised and reliable data exchange ecosystem supported by a publicprivate collaborative framework that will allow the establishment of reliable data sharing agreements break data silos and make the urban freight data more available and accessible driven by the unlocked data an innovative set of 12 urban logistics services will be implemented to optimise the allocation of urban space improve the policymaking capacity of local authorities and optimise network management and logistics operation with unchain public authorities will improve their data collection capabilities and have the right tools to achieve sustainability goals meanwhile for operators having services aligned with their own and societys objectives will unlock mutually beneficial cooperation schemes a key factor for longterm collaboration and the establishment of sustainable urban freight transport policies and operations 10 european cities will participate in unchain activities madrid berlin and florence as living labs prague mechelen madeira and riga as follower cities and brest metropole ravenna and alba iulia as peer cities supporting the early adoption of the results also the wellbalanced representation of the urban logistics industry with dhl and ups will ensure largescale impact and feasibility of the project results
maturing the production standards of ultraporous structures for high density hydrogen storage bank operating on swinging temperatures and low compression

mast3rboost will bring to the stage of maturation a new generation of ultraporous materials activated carbons acs and mofs with a 30 increase of the working capacity of h2 at 100 bar reaching 10 wt and 44 gh2lps by turning the labscale synthesis protocols into industriallike manufacturing process densified prototypes of acs and mofs will be produced beyond 10 kg for the first time using preindustrial facilities already in place the process will be actively guided by unsupervised machine learning while the foundations for an indepth supervised learning in the sector of h2 storage will be established with harmonized procedures recycled raw materials for the manufacturing of the ultraporous materials will be actively pursued both from waste agroforestry biomass and from solid urban waste pet and allined bricks in parallel new lightweight al and mgbased metal alloys will be adapted to additive manufacturing via the waam technology databases for mechanical properties relevant to pressure vessel design will be improved covering gaps for testing under compressed h2 waam and engineering capacities comsol numerical calculation will allow to produce an innovative type i vessel demonstrator including balance of plant and with a dedicated shape to better fit onboard a unique combination of maximum pressure up to 100 bar and carefully selected temperature swing will allow producing a system storage density as high as 33 gh2lsys the system will be manufactured to embed 1 kg of h2 becoming a worldwide benchmark for the adsorbed storage at low compression with a highly competitive projected cost of 1780 for the automotive sector this demonstrator will embody an actual and technoeconomically feasible solution for transportations sectors that require storage capacities beyond 60 kg h2 such as trucks trains and planes lca and risk safety assessment will be performed with highquality data and shared with stakeholders of the sector
exploring novel biobased materials and their applications in conservation and restoration with a new interdisciplinary team

when searching for sustainable materials biobased materials obtained from renewable sources are a promising solution for the future and a priority for the european union biobased2uc intends to expand a new line of research at the university of coimbra uc that lies on two vectors 1 the development of biobased materials focus on nanocelluloses and 2 application of the biobased materials in the conservation and restoration of historical cellulosic objects focus on paper documents for that a new interdisciplinary team will be created under the coordination of the era chair holder aimed to establish a permanent research group in the field beyond the duration of the project the era chair holder will be professor naceur belgacem that in addition to being a prolific researcher has a long experience 16 years in coordinating research groups and institutions he will be assisted by the internal team of uc and an international advisory board besides the development of new products and methodologies biobased2uc will strengthen human capital resources at the uc with bettertrained researchers and technicians in the two vectors of the proposal boost the quality of the scientific research developed at uc by succeeding in publishing in high impact journals and in obtaining competitive funding increase the visibility of uc in bridging interdisciplinary areas within the european research area build a network with the paper conservators in portugal museums archives and libraries with the introduction of the new sustainable approaches these institutional changes will in the long term positively contribute to the achievement of a stronger and more circular economy regionally and across europe taking a step forward towards the sustainable preservation of cultural heritage as well to have a new market for nanocelluloses and creation of new jobs the uc is committed to taking the necessary measures to support the sound implementation of the project
pangea calval center for enhancing earth observation ri in the mediterranean

the greek island of antikythera whose name is linked to the history of science is being transformed into a stateoftheart climate observatory and a pioneer station for climate and weather research in the mediterranean the national observatory of athens noa is building the panhellenic geophysical observatory of antikythera pangea a large remote sensing infrastructure leveraging on a strategic investment of the european investment bank the mediterranean is one of the most climatesensitive areas on the planet and the observatory will fill a very important geographical gap in research on climate change and its implications noa holds significant expertise in earth observation to fulfil this mission but it lacks scientific background in key areas of remote sensing and radiative transfer theory and applications along with certain technological backgroundthe pangea4calval twinning project aspires to fill these gaps by building upon pangea a framework of knowledge ri and management capacity to establish a centre for earth observation eo and satellite calibrationvalidation calval in the mediterranean region the project will enhance the human capacity and ri growth in the region towards supporting frontier environmental and climate research pangea4calval is timely to address the tremendous evolution of eo in both technology and application domains the advent of the socalled new space paradigm along with the additional needs for satellite calval and enhancement of copernicus services the project will apply a comprehensive set of activities to transfer knowhow from advanced partners in europe aiming to fill the identified knowledge gaps and fulfil the project objectives pangea4calval will develop an openaccess framework for pangea with the mandate to bring together academia industry regional authorities and the civil society to transform ri capacities into socioeconomic benefits for the region and the eu
the tsars famines economic policy and famine in late imperial russia 18911911

the turn of the nineteenth and twentieth century witnessed transformational changes in the russian economy marked by rapid integration into global markets and stateled industrialization in the same period russian society faced dramatic crises the most devastating of which were a series of famines that cost millions of lives both dimensions of development have been subject to extensive study but the fundamental disconnect between these historiographies leaves a yawning knowledge gap tsarsfamine will conduct a systematic examination of famine intensity and famine relief strategies in regions of the russian empire between 1891 and 1911 constructing the first comprehensive database of demographic and agricultural statistics at the county level using this novel and unique database a multivariate analysis will identify the causes of famine including the potentially significant role of trade policy the project will then combine quantitative and qualitative sources and analytical methods to examine the effectiveness of different faminerelief strategies adopted in different provinces of russia over the twentyyear period tsarsfamine advance the stateoftheart in several ways it will improve our understanding of the deeper socioeconomic outcomes of the state policies that propelled the industrialization of late imperial russia it will contribute to the broader literature on the effectiveness of famine relief exploiting a richly documented historical case study with significant variation in famine intensity and famine relief policies the project promises important insights for development experts and international institutions that engage in the study of modern famines and engage in global famine relief tsarsfamine will be a major accelerator in the career of the researcher who will benefit from relevant expertise and training opportunities at the host institutions expand her international network and advance her research agenda