Dragon09/odtu_chatbot huggingface dataset:
novel therapeutic platform for aggressive lymphoma nanolymphoma

immunotherapy using antibodies targeting the cell surface has led to important clinical advances in patients with cancer exemplified by cd20antibodies that are firstline treatment in patients with bcell lymphoma however diffuse large bcell lymphoma dlbcl the most common and aggressive form of bcell lymphoma worldwide is still incurable in 40 of patients these patients have poor prognosis due to treatment failure or relapse upon therapy with cd20antibodies 260000 mortalities worldwide in 2020 thus there is urgent need for novel therapies to overcome resistance and enhance antitumor activities in patients with aggressive bcell lymphoma we developed nanofilaments that can efficiently cluster multiple lymphoma membrane targets cd20 and new targets cd22 cd37 to induce potent tumor cytotoxicity this new therapeutic platform nanolymphoma represents a powerful strategy since this approach is independent from genetic cancer subtypes and is broadly applicable in molecular heterogeneous bcell lymphoma subtypes nanolymphoma will evaluate and validate the technical and commercial feasibility of its new therapeutic platform to target human lymphoma cells and prepare for clinical translation to patients with dlbcl nanolymphoma will 1 show that clustering of therapeutic targets on the surface tumor cells potently induces tumor cell death and 2 perform market and business case analyses to ensure commercial feasibility and entry to market through simmunext biotherapeutics nanolymphoma is expected to outperform conventional anticd20 antibody treatment in patients with aggressive lymphoma
fostering the european energy transition with exascale

the energyoriented centre of excellence for exascale hpc applications eocoeiii applies cuttingedge computational methods in its mission to foster the transition to decarbonized energy in europe eocoeiii is anchored both in the high performance computing hpc community and in the energy field it will demonstrate the benefit of hpc for the netzero energy transition for research institutes and also for key industry in the energy sector the present project will draw the experience of two successful previous projects eocoei and eocoeii where a set of diverse computer applications from four energy domains achieved significant efficiency gains thanks to its multidisciplinary expertise in applied mathematics and supercomputing during this 3rd round eocoeiii will channel its efforts into 5 exascale lighthouse applications covering the key domains of energy materials water wind and fusion a worldclass consortium of 18 complementary partners from 6 countries will form a unique network of expertise in energy science scientific computing and hpc including 3 leading european supercomputing centres this multidisciplinary effort will harness innovations in computer science and mathematical algorithms within a tightly integrated codesign approach to overcome performance bottlenecks to deploy the lighthouse applications on the coming european exascale infrastructure and to anticipate future hpc hardware developments new modelling capabilities will be created at unprecedented scale demonstrating the potential benefits to the energy industry such as accelerated design of photovoltaic devices highresolution wind farm modelling over complex terrains and quantitative understanding of plasma coreedge interactions in iterscale tokamaks these lighthouse applications will provide a highvisibility platform for highperformance computational energy science crossfertilized through close working connections to the eera consortium
mediumrange hybrid lowpollution flexifuelhydrogen sustainable engine

mythos proposes to develop a demonstrated innovative and disruptive design methodology for future shortmedium range civil engines capable of using a wide range of liquid and gaseous fuels including safs and ultimately pure hydrogen thus aiming at fulfilling the objective of decarbonize civil aviation as foreseen by the acare sria short mid and longterm goals by 2050 to achieve these the mythos consortium develops and adopts a multidisciplinary multifidelity modelling approach for the characterization of the relevant engine components deploying the full power of the method of machine learning the latter will lead through hiddenphysics discovery to advance datadriven reduced models which will be embedded in a holistic tool for the prediction of the environmental footprint of the civil aviation of all speeds a unique aspect of the project is the highfidelity experimental validation of the numerical approaches mythos consortium through this approach will contribute to reduce timetomarket for engines designed and engineered to burn various types of environmentally friendly fuels such as saf in the short and medium term and hydrogen in the long term the proposed work responds to the needs and objectives of the horizoncl52022d50112 towards a silent and ultralow local air pollution aircrafts call as described in detail below
renewable energy on the high seas scienceinformed and indigenous knowledgebased recommendations for regulatory and governance challenges

the high seas are those marine areas under no states jurisdiction so far all marine renewable energy re activity is being conducted under states jurisdiction however recent advances in technology are raising the prospect of carrying out re activity on the high seas currently only seabed mining activities in the area have been regulated the area is the seabed and ocean floor beyond the limits of states jurisdiction from the legal viewpoint the main gap is a lack of an international regulatory framework informed by participatory mechanisms and supported by scientific evidence for re activities on the high seas especially regarding their environmental and social impacts the primary project objective o is to provide the scientific community and policymakers with scienceinformed and indigenous knowledgebased recommendations in support of the development of re regulation on the high seas two specific os are set to complement the primary o namelyo1 to advance the use of systematic consultation processes that facilitates research at the crossroads of marine sciences and law o2 to advance critical knowledge and understanding of environmental pressing issues comparable to the regulation of re on the high seas such as deepsea mining in the areaa multistep innovative methodology will be adopted by integrating marine scientific knowledge consultative processes and advanced critical research in the subject matter a case study interdisciplinary and participatory involving marine scientists indigenous and coastal communities and policy makers will be conducted onboard the research vessel kronprins haakon at the beginning of the project the case study outcomes will be analysed through critical legal analysis to build a knowledge base for policy recommendations the project will advance the pis career in an international research environment allowing her to generate independent highquality and reproducible results
identification of chemicals in edible fish containing microplastics as potential source for human exposure

microplastics mps are extremely persistent ubiquitous and have the ability to adsorbabsorb chemicals from the surrounding environment marine organisms ingest microplastics and the chemicals are transferred through the food chain and may potentially reach humans through the consumption of fish and shellfish therefore the identification of chemicals arising from this potential human exposure source is of great interest for ensuring food safety and establishing the appropriate legislative framework fishconplastic proposes a simple and robust methodology based on the combination of supramolecular solvents suprass with liquid chromatographyhigh resolution mass spectrometry lchrms that will allow to detect and identify chemicals associated with the intake of microplastics in edible marine species through suspect and nontarget analysis fishconplastic will provide the first overview on chemicalmicroplastic contamination in edible marine species from the mediterranean sea in a second stage the relationship between the chemical present in marine organisms and the microplastics will be investigated for this the quantity size integrity and polymertype of the microplastics found in the marine species analysed will be determined finally all the identified chemicals will be prioritised in a list according to the level of confidence of the identification frequency of detection human risk exposure to chemicals and toxicity fishconplastic will offer to public authorities a comprehensive list of chemicals to be monitored for ensuring food safety which is expected to have a positive impact on net fishery exports in the european community fishconplastic is in line with the european mission on healthy oceans seas coastal and inland waters deepening the knowledge of the mechanisms of chemicals migration and microplastics contribution to the marine species contamination
hydrodynamics and entropy production in lowdimensional quantum systems

in the past years quantum nonequilibrium emerged as a new principal research arena promising to assist the current development of new quantum technologies and to shine a new light on disparate fields of theoretical and experimental physics from black holes to condensed matter and statistical physics as quantum dynamics represents a major challenge for modern computational methods relevant developments have come from devising new generalised and extended forms of classical hydrodynamic theory to effectively describe its macroscopic features this effort is nowadays constituting an essential part of contemporary theoretical physics contributing to a deeper understanding of dynamical phenomena and providing new directions in different experimental areas this proposal focuses on the interplay between classical nonlinear dynamics and quantum evolution promising to a unveil a new deep comprehension of how the nonequilibrium dynamics in manybody quantum systems can dissipate or either recover quantum information and how effective nonlinear classical behaviour emerges b release new efficient theoretical tools to access quantum manybody quantum systems which are strongly interacting and in nonequilibrium settings beyond linear response far away from known regimes of lowenergy lowtemperatures or weak interactions the outcomes will provide new reliable and much needed theoretical methods as well as a new dictionary to catalogue and relate different nonequilibrium phenomena in quantum and classical physics and deepen our understanding of outofequilibrium matter
precommercializing a method for inducing muscle fiber formation for industrial meat production

the global population is expected to reach 9 billion mark by 2050 which will cause an increase of 70 on the global demand for food however if the global trends of meat and animal products consumption continue at the current rate the global mean temperature will rise by over 2c despite the emissions of nonagricultural sectors being drastically decreased therefore a growing need exists to develop more efficient protein production options during embryonic muscle development myoblasts proliferate and undergo differentiation a multistep process which requires cell cycle withdrawal initiation of a muscle specific gene transcriptional program differentiation into fusion competent myoblasts and ultimately celltocell fusion to form nascent multinucleated myotubes that mature to form contractile muscle fibers we have identified a novel signaling cascade that is easily controlled by a small molecule inhibitor leading to faster and more robust in vitro muscle formation than can be achieved with the conventional differentiation medium this occurs through the induction of synchronous differentiation and ultimately enhanced celltocell fusion of the muscle progenitor cells the discovery of a signaling cascade which enhances myoblast fusion draws parallels to the needs of the newly established and evergrowing field of cultured meat which builds upon the techniques used for decades in the in vitro study of myogenesis the cultured meat industry is actively seeking ways to increase production efficiency in order to reach priceparity with the current meat industry therefore taking advantage of processes that can speed up and enhance efficiency of myoblast fusion would facilitate this achievement the goals of the poc project are to improve the maturity of our idea by bringing it to higher trls technology readiness levels implement a precommercial prototype of the proposed product and explore its commercialization potential