Dragon09/odtu_chatbot huggingface dataset:
mobile artificial intelligence solution for diabetes adaptive care

the melissa project aims to provide a clinically validated effective trustworthy and costefficient artificial intelligence aibased digital diabetes management solution to support both health care providers hcps and insulintreated patients with diabetes pwd in their daily routine with personalised treatment and care recommendations the solution is independent of the used glucose monitoring devices and is based on the combined use of already prototyped advanced aiapproaches and innovative tools for quantification of lifestyle and behavioural factors taking into consideration sexgender aspects age and socioeconomic parameters related to the development of diabetes more specifically core element of the project is the daily insulin treatment adjustment to ensure glucose control using an already introduced selflearning approach based on reinforcement learning the approach is datadriven realtime and of low computational cost and allows daily adjustment of the insulin infusion profile on the basis of the fluctuations in the patients glucose the approach takes into consideration patients treatmentrelated glucose insulin and carbohydrate intake and conceptual information and during the project will be further extended and optimized to include additional lifestyle and behavioural parameters furthermore tools for assessing the risk of short and longterm complications will assist hcps in reaching better decisions on adjustments to the treatment schemes to meet the objectives the consortium brings together partners active in the fields of diabetes pwd and hcps diabetes technology ai behavioral sciences ethics in ai regulatory affairs healthcare economics and clinical trials to further cocreate clinically develop optimize and clinically validate an aibased solution for more effective and costefficient diabetes management through personalised treatment and care
novel approaches to error detection and protection with superconducting qubits

superconducting qubits have emerged as a leading platform for realizing intermediate and largescale quantum computing and quantum simulation this success has been due to the exceedingly wide range of qubit encodings and rich physics attainable by combining superconducting circuit elements to achieve high coherence qubits and high fidelity quantum operations in this project i will demonstrate novel approaches to two central aspects of the future of superconducting quantum computing 1 despite the dramatic scaling in the number of qubits the fundamental workhorse to implementing quantum algorithms and quantum error correction is still twoqubit interactions 2 there has recently been a large interest in novel socalled protected qubit encodings for high coherence but none have yet been competitive with standard nonprotected qubits the main results of novadepro will be implementation of a novel qubitqubit coupling mechanism enabling fast microwaveactivated multiqubit gates demonstration of the first singleshot highfidelity fourqubit gate and parity readout enabled by the new coupling technique in a surface code quantum error correction layout a new approach to hybrid superconductorsemiconductor josephson junctions with high stability as demonstrated in our recent experiments and coherence properties compatible with stateoftheart superconducting qubits the first demonstration of superconducting circuits that combine standard insulatorbased and hybrid superconductorsemiconductorbased josephson junctions to implement new highcoherence protected qubit encodings and straightforward quantum control schemes these achievements will push the boundaries of superconducting quantum computing by opening a new path for highfidelity error correction in intermediate and largescale quantum computing and demonstrate a new family of high coherence protected qubits in a firstofitskind hybrid quantum circuit
multispectral scattering matrix for enhanced skin imaging

during the erc reminiscence project we developed a new microscope whose performances exceed our initial expectations based on a reflection matrix approach of wave imaging this device called deepinsight provides an unprecedented imaging performance it allows noninvasive labelfree realtime and threedimensional imaging of tissues with a 1 mmpenetration depth at a 500 nmresolution beyond the structural information provided by standard reflectivity images it also enables quantitative imaging of tissues by mapping biomarkers such as the refractive index tissue dynamics or scattering strength this patented innovation thus represents a paradigm shift in labelfree microscopy in the framework of this project we want to investigate its extremely promising potential for dermatology and cosmetics industry our proposed solution overcomes the fundamental limitations of existing microscopes confocal oct in terms of penetration depth resolution and 3d frame rate it will be a turning point for the early detection of melanoma which remains a blind spot for current technologies beyond this specific problem its real time capabilities will be exploited for noninvasive angiography in order to identify subsurface vascular and structural features known to be associated with numerous skin diseases following the poc project we plan to establish a startup company to further develop the microscope and market it to hospitals and cosmetics industry
innovative tools to treat and model complex cancer environments

theratools has arisen as a multidisciplinary research and training network that encompasses a full academical and technological view of the development of scientific tools for the comprehensive research of malignant tumors localized beyond a biological barrier as in brain tumors this challenging objective needs of the concerted effort of both academic and industrial organizations as such theratools is formed by a consortium composed by a four academic beneficiariespolymatuniversity of the basque country spain university of aveiro portugal italian institute of technology linked to santanna school of advanced studies italy and technion israel institute of technology israel and b 6 industrial partners polimerbio spain beonchip spain metatissue portugal vetex cyprus imed spain and nanoscribe germany all the partners will be involved in both research and training activities framed within this networktheratools consortium and working plan has been configured to stablish a supportive network within a ejd in the topic of the development of innovative tools to treat and model complex cancer environments this network considers the engagement of 9 earlystage researchers that will have the opportunity to be awarded with double doctorate degrees in two different countries theratools network will offer to the esrs high quality training opportunities across several disciplines to conceive a full view of the development of therapeutics from the synthesis of the drugs to their validation in invitro models in its endeavor to translate the experience of the participants into products for health benefit theratools will transfer the knowledge and competences to young researchers providing them with enhanced career perspectives in both the academic and nonacademic sectors through international interdisciplinary and intersectorial mobility combined with an innovationoriented mindset and an excellence level of training
how to make a limb a new insight using threedimensional synchrotron palaeohistology

tetrapods ie fourlimbed animals are the only backboned animals to have truly conquered the land and have achieved worldwide distribution in a wide range of environments several fish groups have attempted to colonise terrestrial habitats eg mudskippers among rayfinned fish lungfish among lobefinned fish but only tetrapods were able to initiate a largescale radiation what is the key to this success our limb skeletons have obviously played a crucial part by allowing us to walk and support our weight outside of the water but that is not their only function for example at some point during the early evolution of tetrapods the haematopoietic blood cellproducing tissue transferred to the bone marrow it has been suggested that this protected the production of blood cells from uv radiation and made it more efficient this extraordinary multifunctionality evolved through successive microanatomical innovations beginning 400 million years ago the underlying reasons and processes are still unclear partly because traditional palaeontological techniques have not been able to uncover the crucial changes in 3d microarchitecture from fin to limb i will overcome these limitations using a novel crossdisciplinary approach based on stateoftheart threedimensional tomographic imaging techniques at high resolution i will combine 3d modelling with virtual simulations of biomechanical stress evidence of biomarkers and functional genomics to provide the first comprehensive picture of three major steps in the limb evolution 1 the shaping of our limb into three segments 2 the origin of bloodcell production in limb bones and 3 the role of ossified mineralised ends in the exceptional locomotor radiations of tetrapods this project will illuminate the process by which our limb skeletons became not just structural props and locomotory levers but essential powerhouses of cell manufacture without which we cannot survive
ecofriendly and costeffective preparation of single atoms catalysts

the design of efficient catalysts is vital for developing advanced catalytic processes which allows to switch to more sustainable industry single atoms catalysts has caught all the attention within the field of catalysis owing to their outstanding catalytic performance being potential efficient systems however their applications in industry is hindered by the low metal loading required and by the lack of an environmentally friendly simple and inexpensive batch preparation method ecofriendly and costeffective preparation of single atoms catalysts ecosacs aims to synthesize several sac formulations using high metal loading through a new and innovative mechanochemistry route allowing their batch preparation in a near future the specific goals of ecosacs are i use of continuous flow mechanochemistry reactor for the synthesis of given sacs formulations mainly composed by reducible metal oxides supported noble ptau and earth abundant cofe metals ii verify the versatility of this new synthesis method iii determine the physicochemical properties and electronic environment of the sacs by using traditional and advanced characterization techniques iv determine the catalytic activity of sacs in selective oxidation reaction of biomass derived molecules and v develop an understanding of the relationship between physicochemical properties and the activity and stability of sacs the results of this project have the potential to introduce a green and lowcost continuous preparation of sacs and thereby develop more sustainable and greener european and global industry sectors being align with the european green deal program area 3 industry for a clean and circular economy throughout this project i will learn new techniques relevant to industrial catalysis develop my skills as an independent researcher and mentor and expand my network to include international collaborations and relationships as transition to an established researcher
toward active nanophotonic using colloidal quantum dots

aqdtive project targets the design of an all nanocrystal nc based active imaging setup this includes the design of a focal plane array fpa ie a camera which active layer is made of narrow band gap ncs and which light matter coupling will be designed to enhance the light absorption other new functionalities such as a bias reconfigurable spectral response are also targeted to transform nc as viable platform of active nonanophotonics a second key development of aqdtive is the design of ncbased light emitting diodes leds with operation from 2 to 5 m this spectral range corresponds to a spectral window where electroluminescence of ncs is currently not reported and where bright sources remain technologically challenging a bright led will then be coupled to a fpa to obtain an all ncbased active imaging setup last to support the development of such device aqdtive includes a deep investigation of the electronic structure in operando a unique setup will be fabricated that enable pumpprobe photoemission measurements while the device is pumped under resonant ie with band edge energy condition and while device is under operation ie under bias application moreover using nanobeam photoemission i target to obtain a direct imaging of the device energy landscape in operando together these objectives will enable a new generation of infrared sensors operated in the extended short and mid wave infrared that will be collaboratively transferred to industrial partners
nextgeneration vaccines and diagnostics to prevent livestock reproductive diseases of worldwide impact

endemic and zoonotic infectious reproductive diseases of livestock cause major economic losses globally and threaten both food security and public health reprodivac will develop new and improved vaccines and diagnostic tools required to better control four priority abortifacient diseases porcine reproductive and respiratory syndrome prrs q fever ovine enzootic abortion oea and porcine brucellosis the consortium spans academia and industry with complementary expertise including structural biology microbiology immunology plant and veterinary sciences this enables us to address reproductive disorders with an interdisciplinary approach 1 applying reverse and structural vaccinology to select and design vaccine and diagnostic candidate antigens 2 exploiting relevant protein expression systems for the production of these antigens 3 producing rationally attenuated and viral vectored vaccines and 4 developing a suite of molecular and immunological diagnostic tests including pointofcare tests poc to discriminate vaccinated from infected animals diva we will develop a broadly protective prrsv vaccine and a serological elisa that will reliably correlate with prrsv neutralising antibody titres we will identify protective subunit vaccine candidates for q fever and validate a companion serological diva test we will further refine an oea vaccine for commercialisation and pursue a complementary approach towards a divacompatible nextgeneration subunit vaccine and serological and molecular divapoc tests we will develop live attenuated brucella suis vaccines and brucellosis diagnostic tests with improved specificity these new vaccines and diagnostics will be further developed by our industrial partners and made accessible to users thereby by using the latest technologies in vaccine and diagnostic development reprodivac will improve animal health and welfare productivity and sustainability of the livestock sector as well as human health
controlling large language models

large language models lms are quickly becoming the backbone of many artificial intelligence ai systems achieving stateoftheart results in many tasks and application domains despite the rapid progress in the field ai systems suffer from multiple flaws inherited from the underlying lms biased behavior outofdate information confabulations flawed reasoning and moreif we wish to control these systems we must first understand how they work and develop mechanisms to intervene update and repair them however the blackbox nature of lms makes them largely inaccessible to such interventions in this proposal our overarching goal is to develop a framework for elucidating the internal mechanisms in lms and for controlling their behavior in an efficient interpretable and safe manner to achieve this goal we will work through four objectives first we will dissect the internal mechanisms of information storage and recall in lms and develop ways to update and repair such information second we will illuminate the mechanisms of higherlevel capabilities of lms to perform reasoning and simulations we will also repair problems stemming from alignment steps third we will investigate how training processes of lms affect their emergent mechanisms and develop methods for finegrained control over the training process finally we will establish a standard benchmark for mechanistic interpretability of lms to consolidate disparate efforts in the community taken as a whole we expect the proposed research to empower different stakeholders and ensure a safe beneficial and responsible adoption of lms in ai technologies by our society
improved high fidelity hydrodynamic model for floating offshore wind turbine analysis

the floating offshore wind turbine fowt industry has rapidly grown from 23mw in 2009 to an impressive 15mw by 2023 with plans for larger 20mw and 25mw capacities this growth poses challenges in cost fabrication manufacturing and installation due to increased floater size and weight low to mediumfidelity hydrodynamic engineering models and higher safety factors are one of the reasons for this surge highfidelity models offer the most accurate representation of the underlying physics minimizing approximations however they come with high computational costs our primary objective is to adopt highfidelity cfdbased hydrodynamic models by significantly reducing computational time using the swense and integrating them into aeroelastic solvers for fowt analysis this methodology involves decomposing the velocity field into incident and complementary velocity fields and solving only the complementary velocity field in the cfd domain saving significant computational time the developed solver will be systematically upgraded four work packages from single floating body to multibody fowt simulations the resulting solver will play a pivotal role in unraveling the aerohydrostructural behavior of fowt systems during extreme wave interaction fostering advancements in operation and maintenance research and effectively addressing technical knowledge gaps in the fowt field there will be experiments to analyze boatfowt interaction as well as to evaluate the developed solver my host institution runs the renowned aeroelastic tool hawc2 and my supervisor is a worldrenowned expert in the numerical development of fowt and physical model testing he is wellsuited to mentor this project with his expertise in both hydrodynamics and aeroelasticity this endeavor will bridge the gap in my expertise transforming me from a hydrodynamicist into an overall floating wind energy specialist while gaining a knowledge base from aerodynamics and aeroelasticity
evasionaware detection sandbox

mobile malware is getting harder and harder to detect this is one of the reasons why malicious apps regularly appear on the official play store despite the considerable effort google and the security industry put into early detection and validation of each application to mitigate this problem evades aims to combine a number of novel techniques developed as part of the erc bitcrumbs project into the first evasionresilient scalable and maintainable sandbox to analyze android applications our current prototype outperforms all opensource and commercial competitors showing a significant technological advantage over the current market we already performed preliminary experiments and the results we obtained are as worrisome for users as they are encouraging to justify a business idea in fact 70 of the android malware we tested with our technology implemented some form of evasion targeting existing malware analysis tools this shows that the data we are using today to decide whether applications are benign or malicious is completely unreliablethe evades project will focus on transforming our prototype serverside component into production software developing the missing clientside components required to produce an mvp and exploring different ways we could sell and monetize our technology we are certain that our solution has the potential to revolutionize the android security market by providing a more accurate and scalable way to collect information about the behavior of applications this is paramount for any mobile security solution as well as for existing and future machine learningbased approaches that today struggle to use the unreliable information provided by existing dynamic analysis systems
coherent rapid optical communication under the stratosphere

communication is the heart of our society however 13 of the world population still does not have access to the internet while the appetite for connectivity is growing worldwide as rf networks are reaching their limits in bandwidth spectrum and security new architectures are required to reach all populations and support increase in traffic laser communication is the ideal candidate but faces issues due to beam scrambling when crossing the atmosphere crocus will develop a high throughput reliable and embedded laser communication terminal based on its unique patented technology cailabs has already built laser communication terminal subsystems demonstrated performance on the ground through strong turbulence and validated the relevance of its solution with early adopters we now need to industrialize it into a mature product that will be integrated worldwide inside ground station drones airplanes ships and any vehicle below the stratosphere
it yet remains to see hybrid electrochemical energy storage system of high power and improved cycle life

this project focuses on the electric energy storage and offers research on novel type of hybrid electrochemical capacitor hec thatstores the energy quickly due to high power efficiently due to reversible interactions inside and demonstrates the satisfactoryperformance over thousands of chargingdischarging cyclesinnovative concept of redoxactive electrolyte as a component that allows for full insertion of the negative electrode will beresearched a comprehensive study including several operando techniques will be provided with elaboration on the mechanismsthat govern the performance fade finally the device of high energy density 50 whkg and power over 1 kwkg retained over atleast 1 000 of cycles is aimed to be delivered
applying new solutions for cultural heritage protection by innovative scientific social and economic engagement

anchise applying new solutions for cultural heritage protection by innovative scientific social and economic engagement aims at offering to european societies efficient methods knowledge and toolkit to enhance the protection of cultural heritage against looting and illicit trafficking crossing the methodology of networking that has proved its efficiency in the h2020 netcher project with the innovative results of new technologies developments 3dphotogrammetry for site monitoring data engineering and ai for border control object identification and heritage collection protection spectral fluorescence signature for object authentication anchise will create an operational set of tools applicable for european contexts and replicable in other situations abroad the aim of the project is to bring coordinated solutions to the key existing needs in the domain of cultural heritage protection 1 understand 2 prevent 3 act 4 repairanchise will consist of 1 a hub of social science politics and economics for indepth results likely to lead to structural evolutions in heritage protection 2 a largescale evaluation of technologies and needs 3 a toolkit of innovative solutions 4 pilot experimentation areas museums border control archaeological sites and 5 a unique and wide network of practitioners9 demonstrations will involve at list 150 practitioners guidelines and procedures on the use of anchises tools will be largely disseminated interpol pandora institutions in charge of cultural heritagethe consortium is a strong partnership of leading stakeholders in the fight against illicit trafficking of cultural objects companies parcs iconem inov research centres fraunhofer iccs cyprus institute universities french school at athens university lyon 2 university of poitiers eui florence cyprus university of technology practitioners frances national police college icom and associations michael culture