Dragon09/odtu_chatbot huggingface dataset:
enhancing social innovation in rural areas

esira acknowledges that innovative social economy initiatives focusing on local networks competences and resources are able to recognise the important role of citizenled activities to fulfil the needs of rural areas especially marginalised ones nevertheless many policies and initiatives fail to effectively support them andor engage the more vulnerable groups of population the main objective of esira is to contribute to the rollout of placebased innovative social economy initiatives for rural inclusion and development in marginalised rural areas by supporting enabling frameworks wellinterconnected policy architecture and directly piloting innovative solutions which ultimately build more inclusive resilient and prosperous rural areas to achieve it esira will implement a work plan focused on i the research of communityled rural innovation spaces able to connect and empower actors reinforce the social capital and sense of community considering the great diversity of rural areas within europe and eventually ii nurturing and piloting social economy initiatives that strengthen the inclusiveness and living conditions of different groups of population in vulnerable situation from the improvement in the provision of social services economic diversification and sustainable management of the natural capital this will enable to iii stocktake and formulate recommendations for policymakers to better support the third sector and local communities increasing the understanding of the needs and challenges of vulnerable groups of population and social economy and iv boost the knowledgeexchange among local actors building up their capacities and facilitating the scale up and replication of social economy initiatives across rural europe 9 regions in 7 european countries will be involved in the project the exploitation and dissemination activities will aim at expanding those regional spaces and replicating our concept in new regions
winds in galaxies

massive black holes bhs reside at the center of galaxies and release an extraordinary amount of energy during their accretion phase such energy drives galaxyscale gas outflows that can significantly influence the evolution of the host galaxy despite the remarkable theoretical and observational progress in quantifying the energetics and dynamics of such outflows establishing their role during the formation and evolution of galaxies remains a longstanding problem in modern astrophysics wings is designed to finally settle whether outflows driven by bhs are able to shape galaxies and their environment or not to achieve this goal we will build up a novel observational and theoretical framework that investigates the role of outflows in the early universe when bhs and galaxies are growing at the highest rates and outflows are expected to be more common and powerful leaving a prominent mark on galaxy evolution thanks to the pi wings will have access to several key observing programs carried out with alma and vlt as well as the guaranteedtime observer gto program 900 hours with the nirspec spectrograph on board the soontolaunch jwst by exploiting both observations of local outflows and zoomin simulations we will develop a 3d kinematic outflow model that will be an asset in i interpreting existing highredshift data and upcoming jwst observations ii characterizing for the first time outflow properties across cosmic time up to z9 and iii identifying feedback signatures in the interstellar and circumgalactic medium properties the combination of jwst alma and vlt observations will enable wings to assemble the largest highspatial resolution survey of multiphase outflows the support from the erc will be crucial to assemble a unique team mixing the observationoriented and theoryoriented approach as a joint effort of observations and simulations is the key to make a major breakthrough in understanding outflows driven by bhs
understanding the drying behavior of polymercoated particle dispersions using optical tweezers

after spilling coffee a telltale circular stain is left by the drying droplet this universal phenomenon known as the coffee ring effect is observed independent of the dispersed material however for many technological processes eg coating and inkjet printing a uniform particle deposition is required and the coffee ring effect is a major drawback in preliminary work i found that the coffee ring effect can be avoided by coating the dispersed particles with surfaceactive polymers which leads to a homogeneous particle film independent of the dispersed material type shape and liquid the aim of the project coffeerings is to provide a fundamental understanding on how the physiochemical properties of the polymer coating affect the interactions of the particles and the drying behavior of the respective particle dispersioni will receive handson training on optical tweezers by the hosting group to fundamentally determine and systematically quantify the changes induced by the polymer coating throughout all stages of the drying process with singleparticle resolution in wp1 i will synthesize a series of model particles with a defined polymer coating and adjust polymer type grafting density and chain length in wp2 i will use optical tweezers to measure their interaction potential in bulk liquid their adsorption rate to liquid interfaces and their interaction potential when confined at liquid interfaces which will mimic the involved interactions within drying dispersion droplets in wp3 i will investigate the drying behavior of the particle dispersions and combine the macroscopic drying manifestations with the microscopic interactions determined in wp2the successful realization of this project will improve the compositions of particlepolymersolvent mixtures to obtain reliable homogeneous deposits which will stimulate technological advances coating and inkjet printing processes
dendrosomatic coupling and global neuronal signaling

the mechanism for anaesthesia has eluded neuroscience despite being used as a medical intervention for more than two centuries two facts are clear lossofconsciousness under anaesthesia correlates with a massive reduction in global neuronal signalling and a decoupling of feedback information we recently found that the apical dendrites of layer 5 pyramidal neurons are effectively cut off from the cell body under anaesthesia and that higher order thalamic input maintains dendrosomatic coupling via the activation of metabotropic glutamate and acetylcholine receptors we hypothesize that dendrosomatic coupling the influence of the apical dendrite on the soma regulates the flow of information around the brain if true this would mean that dendrothalamic coupling is a ubiquitous mechanism by which the brain via thalamocortical interactions can regulate the degree to which feedback is reintegrated into any given cortical column moreover since human pyramidal neurons are twice as long as rodent neurons the issue of dendrosomatic coupling in human neurons is even more profound here we propose to comprehensively investigate this cortical coupling mechanism in vitro and in vivo using stateoftheart approaches developed in my laboratory and specifically designed to investigate dendritic signalling we will also perform experiments in resected cortical tissue from human patients using fastviral expression of optogenetic constructs an approach that we have also developed and tested in my laboratory lastly we use modelling to probe the consequences of dendrosomatic coupling both for singlecell computation and the principles of multicompartment neuronal networks dendrosomatic coupling as a dynamic mechanism for global neuronal signalling is a bold new perspective for which we have clear evidence and which stands to revolutionize our understanding of cortex and possibly also provide insights into more efficient neural network architectures
reinvented through crises the political economy of the western european left within european integration

due to recurring economic and political shocks the past decade has consolidated crisismanagement and resilience as a key priority of the european union eu academic research has long interrogated the ways in which crises are dealt with at the european level yet the excessive emphasis on electoral trends or eliteled processes has failed to capture the longterm quiet politics of support towards european integration the role of european progressives a key source for the european ideals of solidarity and internationalism has received little attention this is surprising given the fact that progressive politics and european integration have both experienced a long series of mutations and adaptations shaped by recurring crises while these processes have been studied separately little attention has been given to their intersection as a result progressive politics has been conceptualised as a passive victim of increasing integration and the eu is often seen as squeezed in the middle between populism and technocratic decision making criseu will build a theoretically informed and impactoriented study to investigate the ideas and group characteristics that through critical junctures create longlasting support to integration the main hypothesis i will investigate is that progressive politics is reinvented at different stages in relation to three interrelated factors 1 the changes in the composition of leftwing social networks in relation to gender age education etc 2 the evolving memories of past crises 3 the shifting understanding of what is needed to ensure euorpean integration beyond academia the proposed research will help political parties and trade unions identify the factors that drive disintegration within the eu the ways in which memory informs crisismanagement and the role played by social networks pluralism in driving policy innovation
comprehensive methodological and operational approach to clinical trials in rare and ultrarare diseases

realised implements a collaborative and comprehensive methodological and operational approach to clinical trials in rare diseasesenabling timely drug development and approval centred on patients needs with high level of evidence reachable in a limitedenvironment the core of realised operational approaches includes the systematic procedures for patients referral the certification ofclinical sites and filling the gaps for successful development of rare and ultra rare diseasesurd clinical trials using 4 urd diseasesfrom 4 european research networks erns realised methodological teams will optimise innovative statistical and quantitativeapproaches for design and analysis of urdcts developed in the past 10 years and refined in the last years to facilitate the regulatorypathway for innovative drug development realised is implemented in a public private partnership consortium including regulatorsand hta bodies representatives to cocreate operational and methodological approaches in an iterative procedure using amultistakeholders agreement process realised will increase the incentives and motivation for the pharmaceutical industry byreducing many uncertainties on the path of drug development in urd that will follow widely accepted rules to achieve theseinnovative approaches realised will capitalise on an international multistakeholders effort as the problem in urd drugdevelopment cannot be solved in a restricted geographical area with the development and deployment of playbooks arising from thecocreated developments realised will ascertain visibility and readiness of the innovations the overall ambition of realised is tochange the paradigm of ct design for urd by enlarging the spectrum of methodological and operational approaches and toestablish a sustainable innovative and optimised ct paradigm for urd medicinal product development programs whilemaximizing the acceptance by all stakeholders
machine learning combined with spectral imaging for inferring the toxicity of micro and nanoplastics

the project aims to advance our understanding of potential risks posed by micro and nanoplastics mnps to human gastrointestinal health through a combination of quantitative experimental and computational approaches leveraging powerful machine learning ml algorithms and versatile spectral imaging techniques towards this goal the project will first deliver a framework to extensively characterise mnps using multiple spectral imaging techniques covering from micro to nanoscale coupled with complementary instruments the fused characterisation data will be combined with experimental in vitro bioassays to develop ml models enabling the prediction of toxicity patterns and unveiling key drivers of mnp toxicity harnessing the broad literature data a knowledgebased deep learning approach will be employed to unlock mechanistic insights into toxicological pathways the most ambitious part of the proposal is to integrate previously acquired knowledge to develop innovative predictive models for predicting human health impacts of mnps based on their physicochemical properties this will be achieved through two independent pathways one built on insights from in vitro experiments and another rooted in extensive literature data the groundbreaking approaches hold the potential to revolutionise the characterisation and risk assessment of mnps significantly reducing reliance on expensive in vitro and in vivo experimentsthis project offers a unique integration of approaches competencies and resources in environmental science life science analytical chemistry machine learning and computer vision and technological developments of spectral imaging instruments the outcomes could yield potential breakthroughs in numerous key applications of tremendous human technological and environmental importance such as toxicological screening of drugs safety assurance and environmental hazard monitoring and open a whole new field of research in toxicology
dynamics of the solar corona in the era of data intensive observations

the aim of this proposal is to establish close research collaboration between several leading european and south american research teams specialising in solar physics and gain new paradigmchanging knowledge about dynamic processes in the solar atmosphere through the systematic research staff and knowledge exchange and joint research efforts exploiting existing data and facilities including innovative data analysis techniques based on the machinelearning approach the expected scientific impact is a major development of our knowledge of the key physical processes operating in the solar atmosphere including breakthroughs in revealing the coronal heating mechanism transformative progress in our understanding impulsive energy realises such as solar flares and cmes major development of mhd wave theory and first application of machinelearning techniques in the study of solar atmospheric wave processes the project includes four scientific work packages which address specific key challenges of modern solar physics and heliophysics quasiperiodic pulsations in solar flares heating of the solar atmosphere and large and fine scale evolution of cmes and a communication and dissemination work package the expected economic and technological impacts include gaining firsthand experience in the analysis of complex oscillatory processes experience in designing and applying machinelearning techniques for pattern recognition novel diagnostic techniques of input parameters for space weather forecasting models creating a ground for knowledge exchange with local industries and production of highlyskilful specialists in numerical modelling and data analysis the expected societal impact is strengthening the research links between the european and s american research communities improving the public awareness of modern solar and heliophysics and motivating school students to pursue careers in science
modeselective abinitio photoinduced dynamics in conjugated polymers

organic conjugated materials ocms possess unique electronic properties compared with other traditional semiconductor materials due to the delocalization and high polarizability of electrons supporting the motion of charge carriers as well as their significant electronic correlation and electronphonon couplings they present a remarkable flexibility allowing to tune their optical electronic and mechanical properties at will through molecular engineering making ocms most suitable for a broad range of technical applications ranging from optoelectronics as components of lightemitting diodes to photovoltaic cellsrigidity and conjugation as well as the interchromophoric geometry play a crucial role in the primary energy transfer mechanisms along aconjugated polymer ie throughbond or throughspace processes the strong coupling between the electronic and nuclear degrees of freedom leads to selftrapping and spatial localization of excitons in a region whose spatial length is determined by conformational defects manipulating these nuclear degrees of freedom may lead to a blockade or an enhancement of energy transfer along the bond recent experiments have pointed out that in specific polymers exciton transfer is a coherent process rather than a sequence of incoherent hopping type events the accurate description of these photoinduced pathways considering all degrees of freedom involved constitutes a challenge to datethe goal of the fellowship is to advance stateoftheart computational methods for describing the photoinduced and laserdriven coupled electronnuclear dynamics of large conjugated molecules with the aim to include quantum coherence effects and to enable predictive calculations of exciton dynamics and of energy transfer in such polymeric systemsthe researcher will carry out the fellowship in the laboratory of collisions aggregates and reactivity university of toulouse iii under the supervision of dr nadine halberstadt
implementing geriatric assessment for dose optimization of cdk 46inhibitors in older breast cancer patients

current evidence from both randomized trials and realworld evidence studies suggests that older breast cancer patients derive clinical benefit from the addition of cdk 46inhibitors to endocrine therapy but with higher risk for adverse events and treatment discontinuation compared to younger patients the important project will design and conduct a pragmatic clinical study with a decentralised approach for older patients with advanced breast cancer aiming at high level of evidence level i with multilayer results that can enable changes in current clinical practice this study will be conducted across 6 six eu countries and will include more than 500 female and male patients the project will also perform a series of analyses over a a wide range of clinicalrelevant primary and secondary endpoints targeting to contribute to current clinical practice and b the implementation of specific strategies aiming at more individualized treatment and followup approaches to a clinical trial setting that highly resembles realworld setting due to the trials pragmatic designthe project will be developed in 60 months by a competitive consortium of 19 partners from 11 countries which corresponds to a wellbalanced structure involving clinical sites smes universities and patient advocacy organizations despite the great diversity of entities within the proposal important partners bring stateoftheart complementary skills ensuring the ability of the consortium to successfully complete the proposed workthis action is part of the cancer mission cluster of projects on diagnosis and treatment
3d nanoscope a highly accessible highperformance device for live cell nanoscopy

contemporary optical microscopy techniques are capable of imaging subwavelength 400nm structures however challenges such as phototoxicity slow acquisition speeds and difficulties in extending to 3d imaging have hindered their widespread adoption in livecell studies light field microscopy lfm allows 3d imaging of biological samples with a single snapshot reducing phototoxicity and allowing fast imaging of whole live cells recent breakthroughs have demonstrated singlemolecule lfm with sub100nm resolution offering a straightforward optical design that holds immense promise for integrating complementary methods to study realtime dynamics in live cells without causing damage3dnanoscope4all will develop and formalise a highly accessible highperformance device for live cell nanoscopy for that three novel yet robust techniques will be merged in a single device i lfm as the core technique ii 3dsrrf facilitating highresolution rapid measurements and iii singlemolecule orientation microscopy providing spectroscopic insights into 3d molecular order the combination of these cuttingedge technologies will enable both structural and dynamic measurements of live cells in a powerful yet affordable deviceafter validation this nanoscope will be used to reveal previously poorly understood processes involved in the dynamics between viral particles 120nm and cell membrane interactions during human immunodeficiency virus hiv infection these advancements will not only broaden the current understanding of hiv infection but also pave the way for future research based on superresolution microscopy techniques applied to other hostpathogen interactions
social learning for urban climate justice in latin america

latin america la stands out as the worlds most urbanized unequal and one of the most disasterprone regions its vulnerability to climate change is rapidly increasing disproportionately affecting impoverished communities in an intersectional manner these communities contribute the least to greenhouse gas emissions do not benefit of economic growth and are excluded from policy making climate justice movements advocate for collective action against such injusticeslearnucj seeks to unpack the potential of social learning for urban climate justice ucj policy making and urban planning learnucj adopts a transdisciplinary approach fostering knowledge coproduction among stakeholders the methodology is participatory ensuring diversity and networkbuilding it employs an ethnographic methodology collecting data through interviews and onsite observations the project will focus on bogot colombia and mexico city mexicolearnucj incorporates training and knowledge transfer objectives under the guidance of dr rodrguezlabajos at upf i will receive training in environmental justice and intersectionality this training will enhance my skills in qda leadership written and oral communication i will transfer my expertise in participatory strategies la policies and governance learnucj plays a significant role in realizing my vision of becoming a professor researcher and a policy advisor for climate justiceto maximize outcomes and impacts learnucj will undertake dissemination and exploitation activities to ensure broad access to outcomes two openaccess papers will be published all communication activities aim to raise awareness about ucj among target groups a major achievement of learnucj will be the establishment of the alliance for climate just cities acjc a collaborative network for social learning and climate justice this network will contribute innovative ideas to inform the development of more equitable policies