Dragon09/odtu_chatbot huggingface dataset:
ion channels in erythrocytes a novel understanding from regulation of erythropoiesis and physiological function to diagnostic measures and therapeutic concepts

erythrocytes represent an estimated 84 of all cells in the human body during circulation they experience a huge variety of physical and chemical stimulations such as pressure shear stress hormones or osmolarity changes these signals are translated into cellular responses through ion channels that modulate erythrocyte function ion channels in erythrocytes have only recently been recognised as the utmost important players in physiology and pathophysiology despite this awareness their signalling interactions and concerted regulation such as the generation and effects of pseudo action potentials remain elusive innovation proposes a systematic conjoined approach using molecular biology in vitro erythropoiesis stateoftheart electrophysiological techniques methods to detect erythrocyte functionality and patient samples channelopathies and other red blood cellrelated diseases to decipher and make use of ion channel functions in terms of disease treatment concepts we need to overcome the challenges that hinder the gain of knowledge within the field using genetic manipulation of progenitors cell differentiation into erythrocytes statistically efficient electrophysiological recordings of ion channel activity that are limited by the heterogeneity of the cell population 120 days of lifespan without any protein renewal or access to large cohorts of patientsour multidisciplinary team includes biophysicists and cell biologists to investigate erythrocyte characteristics and bioengineers to develop diagnostic devices innovation involves academic research centres as well as diagnostic labs providing patient samples blood bank research centres developing cultured transfusion products and smes that provide and develop diagnostic tools or innovative therapeutic red blood cell products the consortium offers onsite training secondments and a variety of courses in transferrable and complementary skills to 10 doctoral candidates
glass circulation in the lower dniester region in classical antiquity compositional identification and social network analysis

the project socglass aims to model intersocietal interactions in the lower dniester region in the classical period broadly 6th c bce to 5th c ce through the archaeometric compositional study of glass supply patterns and an investigation of spatiotemporal distribution of glass artefacts modelled by social network analysis sna the vast lowlands north of the danube delta ukraine and moldova formed a natural contact zone between the grecoroman world and the indigenous peoples of the pontic region glass and glass items were often traded across ethnic and societal boundaries the diversity of origins of imported glass in the region will be clarified by compositional analysis of glass finds primarily from the ancient city of tyras testing a model of longterm stable meaningful patterns of glass supply the fellow will trace changes in glass composition over a millennium and match them to possible changes in trade patterns compiling a new model of glass circulation at the ld frontier the spatial patterns of glass distribution in grecoroman cities and sites of the indigenous groups will be quantified and modelled through directed weighted social networks the latter will be interpreted from a historical perspective looking for evidence of meaningful patterns of intersocietal interactions thus socglas will address the issue of social relationships between the grecoroman world and indigenous groups combining archaeometry and sna to gain unparalleled insight into intersocietal networks in the region of the study this approach provides a meaningful framework for combining typochronological historic and archaeometric lines of enquiry but has only rarely been applied to classical studies and never to an archaeological record of such notable temporal length
multiscale amplitudes for collider physics

the large amount of data that will be collected by experiments at the large hadron collider in the coming years will lead to an unprecedented increase in the precision of their measurements to benefit from these precise measurements and improve our understanding of the fundamental laws of physics we must obtain a broad set of theoretical predictions to corresponding levels of precision crucially these predictions require the computation of multiparticle multiscale twoloop scattering amplitudes involving massive particles this poses a formidable challenge that we are currently unable to meetin recent years a new framework for the calculation of amplitudes has begun to emerge building on a deep understanding of the physical and mathematical properties of the amplitudes it uses numerical evaluations to constrain an ansatz for the analytic form of the amplitudeworking in this framework multiscaleamp will redefine the state of the art in multiscale twoloop amplitude calculation by singling out the main bottlenecks in current approaches in particular it will make use of geometric and mathematical tools to understand the analytic structures which underpin the amplitudes and introduce techniques which can handle a number of scales beyond the reach of current approaches this will lead to a wide set of twoloop amplitude calculations triggering a new era of theoretical precisionin summary multiscaleamp will make revolutionary conceptual developments in multiscale amplitude computations and usher in a new era of precision at hadron colliders it will deliver1 novel approaches for the computation of multiscale feynman integrals2 new techniques for the computation of twoloop amplitudes with many scales3 the necessary twoloop amplitudes for the production at hadron colliders of jets in associationwith heavy particles such as higgs bosons top quarks or vectors bosons
global acoustic interaction and psychoacoustic impact of the autonomous vehicles in interior and exterior noise

future urban mobility is envisioned with electrified vehicles xev with driving assistance systems such as autonomous vehicles av coexisting with other road users like pedestrians and cyclists resulting in smart and sustainable cities with less air and noise pollutionhowever one of the most significant problems with xev in urban areas is the lack of noise the noise reduction of vehicles has been very welcomed by society but with the inherent risk of losing its detectability with particular attention to vulnerable road users several studies reported that xevs are more likely to have more accidents with cyclists and run over pedestrians especially the most vulnerable ones like blind people external noise is one of the perils facing the quietness of xev but the interior noise should also be addressed the internal acoustic and vibration environment would help reduce monotony and increase awareness of drivers using automated driving modes with still required human feedback and contribute to the passengers welfarein xev running at low speeds urban areas most internal and external noises are produced by the electric and electronic elements in the powertrain the electrified powertrain offers the opportunity to create specific sounds following certain requirements and endorsing associations for increasing safety in road users awareness of drivers and comfort appreciationthe gapnoise project aims to define a set of actions to fill the gap between the current knowledge and technology in xev and human psychoacoustics combining the engineering fields of electric motors modelling methods control strategies in addition to the recognized interaction between perceived sound quality and vibration thus establishing an ideal theoretical and practical arena for developing a technologically strong community of scientists engineers and social stakeholders capable of boosting the acoustic integration of autonomous vehicles in future urban areas
neuromorphic flexible electrochemical interface for inmemory biosensing and computing

efficient assessment of multiple biochemical and electrophysiology biomarkers directly at the area of interest is an indisputable asset in the individualized healthcare however current implantable systems and bioelectronic technologies still face limitations in ultrasensitive biosensing address the electrical and chemical aspects fragmentally and depend on complex setups and computationally heavy offline processing conventional von neumann architectures face limitations in efficiently handling the increasing sensor output data that can be mainly attributed to the physical separation between sensing memory and computing units here the overall objective is to conceptualize a firstofitskind miniaturized and selfcontained biosensing technology employing neuromorphic devices functioning as onnode sensors and processors inmemory biosensing and computing in soft flexible and biocompatible materials and format i will demonstrate this technology showcasing in an in vivo animal model a proofofconcept implantable biointerface that intelligently interrogates and classifies neurodegenerative diseaserelated biochemical and electrical biomarkers coupled with active elements enabling precise adjustment of stimulation control parameters based on analog inputs this technology holds great potential to advance our understanding and treatments of pathologies through multiplex electrical and chemical monitoring reducing the demands for powerintensive analogtodigital conversion and computational processing furthermore it paves the way for tailored interventions laying the foundation for nextgeneration biomedical modulation systems
identifying metabolic dysregulation to guide novel foxpidasd therapies

the mechanisms underlying monogenic intellectual disability id and autism spectrum disorder asd affecting 2 of the population remain poorly understood moreover most idasd syndromes are still untreatable the exception being some disorders of metabolic origin therefore identifying unappreciated metabolic mechanisms underlying the pathophysiology of idasd provides a promising avenue to treatmentseveral lines of evidence suggest that the transcription factors foxp124 are idasd genes with such an underappreciated role in brain energy metabolism mitochondrial defects and altered metabolic rate in foxp animal models unpublished foxp brain transcriptome data of my host and gwasbased data indicating that foxp12 genes are significantly associated with body mass index in the general population therefore my main aim is to characterize idasd phenotyperelevant metabolic dysregulation in foxp mutants and ameliorate its effects powerful genetic tools in drosophila allow me to probe specific molecular mechanisms with high spatial and temporal resolution and relate them to clinically relevant phenotypes including locomotion behaviour habituation learning and sleep my objectives are to 1 identify phenotyperelevant metabolic target pathways of foxp 2 characterize metabolic dysregulation in foxp neurons with spatial resolution 3 reverse behavioural foxp phenotypes with metabolic or other innovative therapeutic interventionsthis interdisciplinary approach further develops the data analyses molecular and imaging skills that i acquired through my phd training and allows me to merge it with unique diseaserelevant data clinical knowledge and collaborating networks this project has the potential to provide novel insights into the relation of metabolism cognition and behaviour and revolutionize the treatment of foxp124 disorders these insights may also have implications for further molecularly and clinically related idasd disorders
wire widening innovationresearch excellence in filmeu

wire is promoted by all eight heis currently members or soon to be members in the filmeu alliance filmeu fully represents europes geographical cultural and linguistic differences combined with the diversity and richness of its european higher education area ehea and its research area era wire integrates five out of eight academic partners each coming from widening countries a majority of less researchintensive institutions and is led by an institution from a widening country all wire activities are centered in widening countries and it is these countries and less researchintensive heis that are beneficiaries of the of the project wires main objective is to catalyse a step change in the excellence and innovation of the science and value creation activities carried out by and across the filmeu alliance via its capacity building and the promotion of several reforms across the heis in widening countries participating in the alliance wire will capacitate the filmeu alliance research and innovation ri dimensions notably by focusing on management and administrative competencies for the benefit of its members in widening countries and through that increase the overall competitiveness of the alliance wire will achieve this through deeper and more geographically inclusive cooperation between all members of the alliance wire will contribute significantly to the expected outcomes of the call via the consolidation of an inclusive alliance of heis which mostly 5 of 8 come from widening countries through collaboration between themselves and with other actors in local ecosystems they will promote institutional and countrylevel reforms and upgrades facilitate an embedded culture of excellence and value creation driven by artistic research and focus on the cultural and creative industries in view of increased competitiveness and accelerated institutional reforms in their ri dimension
integrated 4d driver modelling under uncertainty

the vision of i4driving is to lay the foundation for a new industrystandard methodology to establish a credible and realistic human road safety baseline for virtual assessment of ccam systems the two central ideas we propose are 1 a multilevel modular and extendable simulation library that combines existing and new models for human driving behavior in combination with 2 an innovative crossdisciplinary methodology to account for the huge uncertainty in both human behaviors and use case circumstances this rigorous treatment of the uncertainty is crucial to assess how much of our confidence in model inputs parameters and structure is justified it also makes explicit how experts from different disciplines judge the outcomes and how justified the underlying assumptions really are our consortium combines all the expertise needed to develop this methodology eg traffic engineering human factors data computer science we have the experimental means to gather the evidence beyond the stateofart needed to realistically simulate near accidents in multidriver scenarios access to many data sources advanced driving simulators and field labs we have a strong international network to collaborate with and harmonize our approach with academic and professional partners in eg the us nads facility australia uq advanced driving simulator and tracslab connected driving simulator facilities china tongji univ 8dof driving simulator and largescale field lab and japan ntsel finally we have all the relevant partners onboard to test and apply the methodology universities and research labs oems and tier 1 vehicle regulators typeapproval authorities standardization institutes insurance companies i4driving offers a proposition for the short and the longer term a set of building blocks that pave the way for a driving license for avs
whose sustainability understanding and redefining just sustainability transformations through disability and queer perspectives

a major adagio of the sustainable development goals is leave no one behind implying that actions addressing the sustainability challenges of our time should not be only ecologically beneficial but also emancipatory for the most vulnerable and marginalized yet many vulnerable and marginalized groups are often left behind in sustainability research and actions despite the increasing engagement of disabled and queer scholars and societal actors for environmental and climate justice their voices are rarely considered in research and action on sustainability transformations using an inter and transdisciplinary approach this project aims to understand and redefine the oftenneglected contributions of disability and queer scholarship and societal initiatives around sustainability towards new theories methodologies and ethics of just and emancipatory sustainability transformationsweird will 1 overcome the fragmentation of disability and queer scholarship around sustainability 2 explain how disability and queer societal initiatives contribute to just sustainability transformations by subverting ableistic and cisheteronormative social norms 3 develop new theories of emancipatory sustainability transformations that rely on subversive social norms 4 generate new transformative methodologies in sustainability science 5 redefine transformative justice for sustainability and the ethics of sustainability sciencethis project is groundbreaking because it will generate new theories methodologies and ethics to systematically integrate issues of justice and emancipation in the study of sustainability transformations that are anchored in but not limited to disability and queer perspectives overall through the synergistic achievement of all its objectives weird will enhance the potential of sustainability science to generate new knowledge about and for just sustainability transformations
reconnecting maritime ecosystems geospatial mapping of the spaces of flows in portcity regions

how can policy tools and actions facilitate the sustainable development of the portcity regions to mitigate negative externalities of port activities improve logistics efficiency and help a more sustainable integration of the port in the hinterland and urbanised spaces also considering the aftermath of the covid19 pandemic the worldwide shock of the 2020 beirut blast has directed public attention towards the challenges of the close relationship between ports maritimerelated activities and their cities and regions abundant literature already exists on port geography and port city development yet the question of facilitating sustainable port expansion and city development in a limited space remains unanswered we need more indepth exploration of how global flows running through ports reshape the built environment in the reportflows project the definition of the portcityregion is inspired by considering cities and regions as constantly dependant on and composed of complex networks large associations and identities rather than fixed spatial territories marked by clear margins considering the current challenges such as globalisation climate change migration digitalisation and the pandemic i will investigate the spatial planning transport and sustainabilityrelated issues and questions in rotterdam and genoa i will use interdisciplinary and contextspecific definitions and typologies moving beyond traditional portcity studies wp1 glossary and taxonomy i will apply multimethod and datadriven approaches to map and analyse the spaces of flows generated by flows from the sea to the hinterland and vice versa wp2 atlas i will propose tailored policy tools to integrate the transport and socioeconomic potentials with the spatial and social realities wp3 toolbox the outcomes of this research will be communicated and disseminated supporting open science practices wp4
decentralized edge intelligence advancing trust safety and sustainability in europe

edgeaitrust aims to develop a domainindependent architecture for decentralized edge ai along with hwsw edge ai solutions and tools which enable fully collaborative ai and learning at the edge the edge ai technologies address key challenges faced by europes industrial and societal sectors such energy efficiency system complexity and sustainability edgeaitrust will enable largescale edge ai solutions that enable interoperability upgradeability reliability safety security and societal acceptance with a focus on explainability and robustness toolchains will provide standardized interfaces for developing optimizing and validating edge ai solutions in heterogeneous systems the generic results will be instantiated for automated vehicles production and agriculture thus offering innovation potential not only in the generic hwsw technologies and tools but also in the three target domains these technological innovations are complemented with business strategies and community building ensuring the widespread uptake of the innovations in europe edgeaitrust will establish sustainable impact by building open edge ai platforms and ecosystems with a focus on standardization supply chain integrity environmental impact benchmarking frameworks and support for opensource solutions the consortium consists of major suppliers and oems encompassing a broad range of application domains supported by leading research and academic organizationsby embracing the opportunity to specialize in edge ai europe can maintain its position in the global context especially as it aligns with decentralized and privacydriven european policy furthermore as ai is closely connected with the green deal this project can provide proper solutions for environmental issues ultimately the project will enable ai to be connected with other strong sectors and industries improving the innovation process and decisionmaking in europe
glass alchemy and medicine evidences of domestic practices in the capital of the andalusi caliphate

the study of material culture is one of the main tools for the past societies knowledge recently new techniques protocols and disciplines applied to traditional archaeological methodology have proved that glass played an important role in economic and social development through history regard to the iberian peninsula works on archaeological glasses has focused on purely typological issues above all from the roman times leaving aside other later historical periods as part of our cultural heritage the study of glass in alandalus can help to understand aspects and practices of andalusian societies for this reason the project glass alchemy and medicine evidences of domestic practices in the capital of the andalusian caliphate galene is proposed which main objective is to establish the classification of glass for cosmetic and medicinal uses in domestic contexts of this period this project proposes the study of an important set of glasses from cordoba spain by combining different skills and multidisciplinary approaches traditional studies experimental archaeology and the chemical analysis of materials to determine for the first time the importance of glass in alchemy and medicine in medieval times the origin and manufacture of these vessels and objects their evolution and whom used them with especial attention to the female gender galene will be conducted by dr velo at the glass and ceramics for the arts vicarte research unit of the universidade nova de lisboa portugal under the supervision of prof vilarigues vicarte is a research group of international relevance that combines different areas for the study of glass in antiquity and in the plastic arts this centre has the facilities and technology necessary for the development of this project that will reinforce the protection of our cultural heritage and contribute to the integrity of the cultural diversity of todays society which is the result of our past and history