Dragon09/odtu_chatbot huggingface dataset:
numerical experiments in particle oceanic turbulence based on new computational and analytical perspectives

marine microplastic pollution has emerged as a global environmental problem in recent years presenting numerous challenges to ecosystems and human health microplastics originate from a variety of sources posing a threat to marine organisms and ultimately the food chain in recent times there has been a significant increase of research related to this topic from multiple angles however the fluid mechanics understanding of this problem in terms of distribution and aggregation of microplastics in ocean turbulence is still a topic in its infancy the neptune project thus aims to provide new theoretical insights and computational tools with the final goal to better understand the problem and contribute to the european mission restore our oceans and waters the project is designed to be very ambitious and highly interdisciplinary indeed from a scientific perspective the foundation upon which it is constructed consists of computational science fundamentals of fluid mechanics and turbulence physicsbased modeling and data science harnessed through advanced machine learning techniques each of these elements is designed to be pushed beyond the boundaries of the current stateoftheart to yield novel scientific and technological insights that will drive socioeconomic advancements the projects primary goals encompass i the extension of an advanced computational solver to simulate microparticles within ocean turbulence in conjunction with various biophysical models ii the better understanding of the distribution and aggregation of microparticles in turbulence and iii pioneering the utilization of datadriven techniques to obtain reduced order models and unravel the intricate nonlinear behavior of microparticles in turbulent environments in this regard the candidate through this fellowship plans to boost his academic career by integrating toptier research with training dissemination and networkcreation activities
imidazole propionate and fibrosis in cardiometabolic diseases

fibrosis is a pathological feature caused by excessive extracellular matrix secretion resulting in scar tissue that causes thickening and loss of tissue mobility culminating in impaired organ function it is a common feature of heart failure and nonalcoholic steatohepatitis and an important determinant of morbidity and mortality however relatively little is known about the underlying aetiology we and others have mapped alterations in the gut microbiota in different cardiometabolic diseases focusing on the functions performed by the microbiota impact builds on our work showing that humans with type 2 diabetes have high plasma levels of the microbial metabolite imidazole propionate imp and that imp impairs insulin signalling through p38gamma we also resolved the xray crystal structure of urocanate reductase urda the bacterial enzyme responsible for imp production our recent work showed that imp is more strongly associated with heart failure and that treatment of mice with imp promotes both cardiac and liver fibrosis consistent with studies showing that p38gamma signalling is implicated in fibrosis developmentimpact will first use stateoftheart clinical assessments to determine how circulating levels of imp correlate with fibrosis in heart and liver second we will explore the kinetics by which imp induces fibrosis in mice and how this process is associated with immune cell infiltration and disease progression third to provide mechanistic understanding we will perform similar experiments in mice lacking key target signalling components eg p38gamma combined with single cell sequencing that will guide us in producing tissuespecific knockouts to elucidate the cellular crosstalk fourth we will generate urda inhibitors and test their potential to reduce imp production in isolated bacteria complex microbial communities and colonised mice thus impact has the potential of generating new therapies to diseases with unmet clinical needs
a giant leap for keyword spotting

speech technologies like keyword spotting kws which is concerned with the detection of keywords from an audio stream comprising speech are nowadays in vogue thanks to their integration in many electronic devices in order to comfortably interact with them by means of the voice despite all the research progress made over the last decades the performance of speech technologies is still severely degraded when acoustic distortions like background noise or reverberation are present this can make these technologies completely unusable for the realworld applications as a result this project proposal aims at taking kws technology forward by researching and developing novel stateoftheart acoustic distortionrobust methods based on concepts successfully applied to related areas like automatic speech recognition to get a leap of kws performance in realworld ie noisy acoustic conditions this will be achieved while working towards two different and exciting timely goals with high social impact giving an interdisciplinary dimension to this action 1 the preservation of the nasas apollo mission speech recordings for future generations during the outgoing phase and 2 the improvement of hearingimpaired peoples life quality by facilitating voicebased interaction with hearing assistive devices like hearing aids during the incoming phase
cybersecurity platform used for scoring predicting and remediating potential security risks

enthec is an earlystage deeptech startup pioneer in the development of cybersecurity solutions against cybercrime mara rojo cofounder and ceo of enthec is a computer engineer phd in telematics with more than 12 years of experience in cybersecurity at corporates such as bbva santander indra or airbus who is becoming one of the leading women in the european cybersecurity ecosystem constantly emerging sophisticated cyberattacks jeopardize thousands of businesses every minute of every day europe must build resilience to cyberattacks while making sure that data protection and freedom of citizens are strengthened that is why enthec is developing kartos a unique cybersecurity platform used for scoring predicting and remediating security risks based on artificial intelligence that analyses the companys leaked information anywhere on the internet deep web and dark web kartos instantly identifies vulnerabilities active exploits and advanced cyberthreats to help companies rigorously protect their business and strengthen their security posture from outside its it perimeter enabling them to see what a hacker sees thus remediating risks before a potential attack the cybersurveillance platforms market is dominated by us companies which may alter their analysis by strategically affecting european companies kartos is the only european solution able to defend the sovereignty of european companies in this market cybersurveillance platforms are a niche market within the cybersecurity marketplace in which enthec will commercially target the european north america latin america and middle east valued at 6000m in 2027 at that time the global cybersecurity market will be 281000m according to grand view research the successful completion of the development and commercialization of kartos is a great business opportunity for enthec to become a european cybersecurity leader and to generate revenues of more than 20m by 2028 and more than 90 skilled jobs
soils for europe

soils are under multiple pressures including climate change urbanization pollution overexploitation and biodiversity loss the specific objectives of the eu mission a soil deal for europe address all these pressures needing now i actionable research and innovation roadmaps for its concretization and ii an overarching transdisciplinary agenda to identify the thematic and regional tradeoffs and synergies that allow the sustainable use management and protection of european soils defining such an agenda requires the direct involvement of a wide range of stakeholders bringing together multiple perspectives and ecological environmental economic and social contexts to do that at the core of solo will be the implementation of think tanks one for each soil mission objective with the aim of cocreating knowledge and identifying the knowledge gaps drivers bottlenecks and novel approaches as well as suggesting kpis to monitor the progress of the mission ri related activities together with an open digital platform the think tanks will function as an operational tool for implementing a participatory process that will last beyond solos lifespan solo will also address the potential differences in the regional implementation of the soil mission by testing its approach in four cocreation regional nodes generating their own regional roadmaps that will be matched with the european ones these explicit linkages between the cocreation mechanisms and the different project components aim to produce a shared understanding of needs and comprehensive identification of research and innovation priorities and other critical activities for the success of the soil mission
the filmmaker in brazilian indigenous communities the impacts of a new social and political position

this project combines approaches from anthropology and film studies to investigate how the systematic use of audiovisual equipment and techniques has contributed to the creation and consolidation of the position of the filmmaker in brazilian indigenous communities designed in collaboration with indigenous filmmakers it will study three communities from different parts of brazil each with different histories and traditions of filmmaking the kuikuro the maxakali and the guajajara in undertaking these studies bfic proposes an expanded and comparative analysis of the filmmakers consolidation as a new socialpolitical position that holds great prestige alongside traditional roles like the community leader the health agent the shaman and the teacher around 90 of brazilian indigenous communities now have their own filmmaker they are responsible for transmitting technical audiovisual knowledge to younger generations for cultural registration and for disseminating information to mainstream media however it is also undeniable that indigenous production has gone beyond the limits of ethnographic film and occupies a place in wider cinematographic culture the filmmaker is therefore central to the exchange of symbolic production and their work contributes to subverting and decolonising commonly held visual notions of what it is to be indigenous the open access journal articles and collaborative short film produced by this project will explore the consolidation of the position of filmmaker in detail for the first time alongside a range of dissemination activities targeted at academics and an interested general public it will also hold audiovisual workshops in indigenous villages to directly strengthen ties between the kuikuro maxakali and guajajara communities in doing so bfic will help to reinforce the struggle of indigenous peoples for the right to land life and the preservation of the environment
enabling virtualized wireless and optical coexistence for 5g and beyond

ewoc project aims at developing a novel converged optical wireless network solution relying on a flexible virtualizable infrastructure required for full resource optimisation beyond 5g b5g requirements fundamental innovation will be sought through merging of the enabling concepts of optical layer virtualization high frequency mmwave transmission multiple antenna technology cell densification terraoverfiber tof based femtocell connectivity and cloud radio access network c ran architecture ewoc will aim at high capacity low latency communications 4090 ghz frequency providing the basis for a 50fold improvement over the 5g baseline this necessitates development of novel femtocell technology and seamless coexistence with first round legacy deployment such scenario also requires novel channel models and simulation methodologies to attain the desired tradeoff between coverage throughput and densification limits ewoc will rely on fiberoptic deployment towards tof connectivity as an added on feature for the cran architecture supporting resource management of versatile services with varying demands scenario compliant optical fronthaul virtualisation techniques designed to provide cost effective beyond stateoftheart resource optimisation will be pursued through novel optical transceiver schemes and software defined networkbased digital signal processing techniques research and training disciplines will serve as building blocks towards the scientific and socioeconomic goals of increased capacity coverage flexibility spectral efficiency cost effectiveness vendor agnosticism and upgradability ewoc provides a framework for promotion of such interdisciplinary innovation with strong interoperability of models and methodologies from different disciplines as such ewoc training network is designed to foster opportunities for scientific and professional growth of esrs from both topical and interdisciplinary standpoints
groundwater discharge of carbon in permafrost peatlands discpp

a better understanding of highlatitude terrestrial carbon c cycling is essential for predicting global climate futures this urgency arises from the large c stocks present in permafrost soils and the rapid regional warming observed during the past decades complexity introduced by strong coupling between hydrology soil temperature and biogeochemical processes in these systems impedes efforts to close the c budget and understand the fate of newly thawed soil organic c notably groundwater discharge of c gdc stands out as a significant source of uncertainty in the highlatitude c budget because these fluxes are difficult to measure highly heterogeneous and strongly impacted by permafrost thawthe main objective of the discpp project is to improve understanding of gdc fluxes within permafrost peatlands groundwater plays a key but uncertain role in the functioning of these distinctive crich wetland ecosystems by combining field measurements with ecosystem modeling discpp will address three knowledge gaps 1 what are dominant drivers responsible for spatial and seasonal fluctuations in gdc from permafrost peatlands 2 how will climateinduced changes to hydrology and c cycling impact gdc and 3 what is the contribution of gdc to the overall c balance of permafrost peatlands the project will be conducted at stordalen mire an intensively characterized permafrost peatland in subarctic sweden the modeling component will employ ecosys a validated processrich mechanistic ecosystem model that has demonstrated applicability in highlatitude ecosystemsdiscpp would significantly advance my career via relevant skill development exposure to different highlatitude ecosystems and establishment of new relationships with leading experts in ecohydrology additionally the project will enhance comprehension of how lateral c fluxes via groundwater discharge impact highlatitude c cycle and climate feedbacks a current gap in global climate models
designing allcarbonbased colour tunable random lasers for speckle free imaging applications carlito

the practical application of conventional lasers is often hampered by inherent difficulties related to their bulky expensive and highly coherent nature some of these issues can be overcome by socalled random lasers rl devices in which laser emission stems from the random walk of photons in a disordered medium however achieving efficient tunable and stable rl remains difficult to date a large variety of nanostructured metals and semiconductors organic dyes and quantum dots qds were proposed as passive or active scatterers to fabricate rls however organic dyes usually suffer from rapid photobleaching while semiconductor qds are affected by fluorescence blinking and their toxicity can be a serious pitfall in biomedical rl applications carlito proposes the use of carbon nanostructured materials cnms to design an entirely new class of rls for a wide range of photonic applications where a stable and lowthreshold rl is obtained by the combined use of different cnms as active and passive light scatterers the ambitious goal of carlito is designing the first allcarbonbased rl acrl capable to yield highquality rl from hybrid cnms by taking advantage of the peculiar electronic properties of different zero one and twodimensional nanocarbons acrls will be a new family of lowcost nontoxic and fully biocompatible rl devices which can be easily tuned to emit photons within the entire visible spectral region achieving these targets will advance rls well beyond the current stateoftheart favouring their transition into realworld technology such as in live cell microscopy speckle free imaging and sensing in particular the application of acrls in speckle free imaging will be directly tested within the scope of carlito
tritium impact and transfer in advanced nuclear reactors

the titans tritium impact and transfer in advanced nuclear reactors multidisciplinary project is built to contribute to research and innovation to improve knowledge on tritium management in fissionfusion facilities and provide robust science to eu safety regulators radiation protection authorities and decision makers titans will answer the main challenges of the call i tritium permeation description and associated modeling ii tritium measurement iii mitigation of tritium release iv gain expertise on dismantling activities v improve knowledge in radiotoxicity and radiobiology both combined to dosimetry specific to each biological model studied the titans work program is established from the results obtained in the former eu transat project and thanks to scientific discussion within transat sac titans members and external experts from eubroader countries titans will improve modelling tools to assess tritium inventorymigration in nuclear fissionfusion reactors in order to identify where the new barrier concept developed within titans are needed to limit the spread of tritium the tritium release during dismantling of tritiumcontaminated setup will be evaluated with the help of innovative tritium inventory measurement techniques developed within titans finally to ensure tritium circular economy a mobile device for tritiated water processing will be developed at last human and environmental toxicity impacts after an accidental release of tritiated particles will be assessed through studies on i the behaviour of aerosols in the environment ii biological effects on a mussels population iii biokinetics by the skin route and iiii genotoxic effects on human lung macrophages in order to estimate a doseresponse relationship a dosimetric study specific to each organism or cell type will be carried out this 3 years project with a 3 m allocated budget gathers 21 partners from european countries and uk all involved in tritium activities
insectbrain inspired neuromorphic nanophotonics

we propose nanophotonic onchip devices for integrated sensing and neural computation inspired by the insect brain this will uniquely combine four lines of research 1 progress in understanding insect neurobiology that provides proven circuit designs to solve significant problems such as autonomous navigation 2 advanced iiiv semiconductor nanowire technology that exploits light to obtain a large number of interconnects with extremely low power consumption 3 optically efficient stable molecular dyes that can be used for novel memory components 4 circuit technology developed for quantum computing as proof of concept we target the complete pathway from polarised light sensing in the insect eye to the internal compass and memory circuits by which this information is integrated in a continuous accurate estimate of location building on verified models we will first demonstrate that the computational principles can be implemented using overlapping light signals in a nanoscale system with high error tolerance and orders of magnitude better energy and spatial footprint than present technologies we will then explore neuromorphic memory functionalities from nanoelectronics and molecular dyes in parallel with deeper investigation of the memory substrates in the insect brain the same nanostructures used for computing can be used for optical sensing and we will develop an integrated sensor and information processing array to extract global orientation information from polarised skylight the direct outcome will be an energy efficient robust chip enabling autonomous vehicle navigation without gps with many potential applications but more importantly the novel neural components we will develop can then be reassembled into a wide spectrum of circuits to mimic other computations in the insect brain the technology platform can be integrated with silicon technology and we will demonstrate the pathway to upscaling and commercialization
engineering human cortical brain organoids connections to restore brain functions

brain injuries affecting the cerebral cortex result in devastating neurologic deficits from irreversible loss of neurons and still do not have any therapeutic option the only possible treatment for these conditions would be the reconstruction of the lost neuronal circuits which could be achieved in principle by stem cell therapy however when stem cells are engrafted they only provide trophic effect and are incapable of substantial tissue replacement and rewiring the damaged tissue with this project i aim at implementing a paradigm shift toward a new targeted therapeutic approach enabling restoration of functional neuronal network activity in cortical brain lesions in this view i aim at i developing a humanspecific hydrogel able to support cortical brain organoids cbos engraftment ii achieving in vitro guidance of functional neuronal connections between cbos via 3 dimension 3d bioprinting iii connecting cbo and lesioned mouse visual cortex using intravital 3d bioprinting iv achieving in vivo functional network restoration via guided cbo integration within the lesioned cortex circuit i already developed in vivo fabrication of customized 3d hydrogels by 2photon mediated crosslinking of photosensitive polymers in cortical brain of living mice adjacent to implanted cbos able to guide cbos growth in vivo the groundbreaking nature of connect lays on the novel idea of i creating in situ extra cellular matrix ecm mimic structures to reestablish in vivo the neuronal network and the lost neurological functions ii using brain organoids as an electrically active unit with defined organized structure to stimulate brain plasticity and reinforce synaptic connections with the host brain tissue the proposed project has the potential to provide a new beyond stateoftheart therapeutic option for cortical brain lesion therapy only possible combining multiple competences belonging to different fields neuroscience cell therapy bioengineering