Dragon09/odtu_chatbot huggingface dataset:
empowering neural rendering methods with physicallybased capabilities

while long restricted to an elite of expert digital artists 3d content creation has recently been greatly simplified by deep learning neural representations of 3d objects have revolutionized realworld capture from photos while generative models are starting to enable 3d object synthesis from text prompts these methods use differentiable neural rendering that allows efficient optimization of the powerful and expressive soft neural representations but ignores physicallybased principles and thus has no guarantees on accuracy severely limiting the utility of the resulting content differentiable physicallybased rendering on the other hand can produce 3d assets with physicsbased parameters but depends on rigid traditional hard graphics representations required for lighttransport computation that make optimization much harder and is also costly limiting applicabilityin nerphys we will combine the strengths of both neural and physicallybased rendering lifting their respective limitations by introducing polymorphic 3d representations ie capable of morphing between different states to accommodate both efficient gradientbased optimization and physicallybased light transport by augmenting these representations with corresponding polymorphic differentiable renderers our methodology will unleash the potential of neural rendering to produce physicallybased 3d assets with guarantees on accuracynerphys will have groundbreaking impact on 3d content creation moving beyond todays simplistic plausible imagery to full physicallybased rendering with guarantees on error enabling the use of powerful neural rendering methods in any application requiring accuracy our polymorphic approach will fundamentally change how we reason about scene representations for geometry and appearancewhile our rendering algorithms will provide a new methodology for image synthesis eg for training data generation or visual effects
lipid droplets as innate immunity hubs

successful defence against invaders is critical for survival of eukaryotic cells microbes have developed many strategies to subvert host organisms which in turn evolved several innate immune responses to counterattack as major lipid storage organelles of eukaryotes lipid droplets lds are an attractive source of nutrients for invaders pathogens induce and physically interact with lds and the current view is that they hijack lds to draw on substrates for host colonisation we recently challenged this dogma by demonstrating that lds are endowed with a regulated proteinmediated antibiotic activity our work introduced the new concept that dependence on host nutrients is a generic achilles heel of intracellular pathogens and lds a chokepoint harnessed by innate immunity to organise a frontline defencehere we have formed a multidisciplinary group combining complementary knowledge and transdisciplinary expertise to investigate the hypothesis that lds are innate immunity hubs sensing infection and directly confronting invaders we will characterise in cells and animals how lds efficiently coordinate and precisely execute a plethora of immune responses such as killing signalling and inflammation highthroughput proteomics and lipidomics will identify defensive players 3d electron tomography and confocal microscopy will be combined with proximity labelling strategies and biochemical methods to get unprecedented understanding of host ldpathogen dynamics the successful pathogen mycobacterium tuberculosis will be used to test the medical significance of our findings and unravel bacterial mechanisms of resistance to ldmediated defencescharacterisation of these novel innate immune systems will be paradigmshifting in immunology physiology and cell biology in the age of antimicrobial resistance and viral pandemics unravelling how eukaryotic lds fight and defeat dangerous microorganisms will inspire new antiinfective therapies
promoting innovation for sustainable sorting and recycling of dedicated biobased plastics

biobased plastics are now seen as an ecofriendly substitute for traditional fossilbased plastics interestingly aside from their environmentally friendly origins and in some cases their biodegradability biobased plastics present a promising market potential for recycling particularly through chemical depolymerisation nevertheless before recycling biobased plastics must first be separated and isolated from other packaging materials achieving effective sorting of biobased plastics presents a challenge in the market as biobased plastics require scale to be sorted and to form a circular economy yet they also need circularity as a sustainability selling point to boost their salesthe prosper project brings together three biobased plastic producers including pla and aapeblend producers a major brand owner an epr schemepro participant a supplier of aisorting technology a sorting testing center four waste management companies a municipality and a specialised consultant it is supported by the scientific expertise of three research institutions and universities as well as a policyoriented nonprofit organisation the project offers a comprehensive approach by developing policy interventions epr fee scenarios and quantifying recycling rates and cost benefits associated with these scenarios it also focuses on demonstrating technical advancements in sorting and recycling at industrial scale inside four real waste management companies prosper will also evaluate the market potential for recycled biobased plastic products through consumer studies engagement with companies and pros while also assessing the life cycle social life cycle material circularity indicators and economic business modelsthe institutionalisation of a system change by the different stakeholders in the biobased plastics value chain will be crucial in achieving circularity improving environmental performance and fostering positive impacts in the biobased economy
quantum longrange networks

longrange interactions enable a wide range of novel scaling phenomena in the outofequilibrium behaviour of quantum systems these dynamical phases are particularly relevant to quantum computation as they feature enhanced coherent properties and fast spreading of quantum correlations currently longrange interacting systems evade description in terms of the conventional manybody theory toolbox due to their highconnectivity and to the appearance of metastable states which pose a formidable challenge to state oftheart numerical simulationsqlrnet hinges on the construction of a unified tool exemplified in terms of a prototypical manybody theory model which reproduces the spectral properties of longrange interactions in a modular structure amenable to extensive numerical investigations then the project will focus on the spreading of quantum correlations and entanglement anomalous dynamics and ergodicity breaking universal quasistatic dynamics dynamical phase transitions prethermal phases and universal defect formation the qlrnet approach is organized in such a way to provide both basic intuition and formal understanding while making quantitative predictions for scaling phenomena that can be realised in experimentsthe study of quantum longrange networks will provide at least two solid paths to uncover new physics 1 first by reproducing the lowenergy physics of longrange interactions in a system with reduced connectivity it will give access to novel phenomena which shall also appear in fullyconnected longrange interacting systems 2 secondly it will provide quantum manybody theory with a novel toolbox to understand critical phenomena in nonhomogeneous systems and their role as a source of fresh and vital problems which could be realised in atomic molecular and optical experimentsqlrnet will open a new era of manybody theory where novel dynamical phases are realised by tuning the lowenergy property of interacting systems
reclaiming liberal democracy in europe

in recent years it has become clear that what is frequently described as posttruth politics will be one of the central challenges facing liberal democracy in the 21st century this project addresses the implications of this challenge drawing on a multidisciplinary approach the project will generate a conceptual definition as well as an operationalization and empirical indicators for the analysis of posttruth politics spell out the ways in which posttruth politics constitutes an existential threat to liberal democracy analyze the state of play as regards various dimensions of posttruth politics in europe and use its own empirical findings regarding the state of play to develop policy recommendations methods and toolkits as to how best to respond to various expressions of the phenomenon the project is structured along a temporal and a thematic axis on the temporal axis the project will proceed in three consecutive phases ie a methodologicalconceptual an empiricalanalytical and a criticaladvisory phase on the thematic axis the project is divided into nine academic work packages that address central components of posttruth politics from the perspective of preconditions how such phenomena have come about expressions how they manifest themselves in political processes and potential responses how their effects can and ought to be mitigated the projects academic work packages address posttruth politics from the vantage points of populism public sphere dynamics and impacts on political culture the role of technological aspects in fostering the rise of posttruth politics the twin roles of lack of trust but at the same time also increased demands for quality journalism strategic disinformation as an external challenge to liberal democracy the impacts of regulatory responses to disinformation and importantly also the role that citizenship education and media literacy can play in mitigating the challenge of posttruth politics
flexibly scalable energy efficient networking

flexscale advances disruptive research on complementary optical xhaul network technologies for optical switching nodes and their transceiver interfaces that enable flexible capacity scaling 10 tbs rate per interface 1 pbs capacity per link and 10 pbs throughput per optical node based on utilization of ultrahigh bandwidth photonicplasmonic technologies and the efficient exploitation of optical spatial and spectral switching ultrawideband spectral spatial lanes multiplexing uwbsdm the developed xhaul 6g optical network innovations will achieve record energy efficiency subpj per switchedtransmitted bit and low cost enabled by photonic integration and optical transparency replacingbypassing powerhungry and costly electronic processing systems eg electronic routersswitches the optical nodes and their transceiver interfaces will be controlled by mlenabled sdn control plane approaches that incorporate new resource allocation algorithms and protocols relying on emerging information models and enabling autonomous programmable disaggregated open networks which will optimize traffic flow routing across network layers and segments improving network qos high rates low latency high reliabilityavailability and low costpower consumption as required by 6g specificationsflexscale consortium spans the value chain of industryacademia experts on the targeted topics transformational transceivers and optical switches network planning operation algorithms and protocols development with demonstrated experience on delivering on their promises as indicated by their research output and exploitation towards new products services and standards contributions flexscale is poised to extend europes leadership in 6g xhaul with offerings of highestcapacity flexible optoelectronic interfaces and fast switching nodes that fully exploit the optical spatialspectral resources with the use of novel algorithms and controlplane implementations
neural markers of social brain activation in humanrobot interaction

with the imminent introduction of artificial agents into our digital future robots will become teammates companions and counterparts however it remains unclear whether people would interact with humanoid robots as social partners or use them as mere tools neuromarkerhri seeks to identify neural markers of the activation of social cognitive mechanisms with robots based on hemodynamic responses using supervised ml models this will determine whether the human brain interprets the behavior from a humanoid robot using social eg mirror neuron system theory of mind or general domain cognitive mechanisms eg attention cognitive control with a hypothesisdriven and stepwise approach the project will measure hemodynamic responses with functional nearinfrared spectroscopy fnirs in brain regions associated with social cognition theory of mind and perception of mental states during collaborative interactions with humanoid robots hemodynamic signal features will be included in the machine learning models to identify predictors of social or general domain cognitive mechanisms the projects interdisciplinary nature integrates welldocumented methods of cognitive neuroscience advancements in robotics and stateoftheart machine learning techniques to thoroughly evaluate the factors that modulate the activation of the social brain exposed to humanoid robots outcomes will set standards for future research in humanrobot interaction offer a reliable tool for designers to measure the effect of robot behavior on the users and boost the development and improvement of efficient humanrobot collaboration the current project contributes to creating a humancentered development of technology and would help towards the digital transition in europe allowing to unlock the potential of social industrial and commercial humanrobot collaboration
harnessing quantum resources in network communication and their thermodynamic underpinnings

we are currently at the midst of second quantum revolution a transformative era harnessing various quantum resources for the efficient execution of communication and computational tasks previously unattainable through classical means during the recent past the pointtopoint communication scenarios have seen extensive exploration and practical realization of quantum resource benefits across diverse quantum architectures within the realm of network scenario typical communication systems involve multiple distant parties seeking to exchange information in the present project our primary objective is to delve into the advantageous applications of several quantum resources including quantum superposition quantum entanglement quantum steering and quantum nonlocal correlations in the context of network communications our focus is particularly directed at two broad channel categories in the network scenario the multiple access channel mac featuring multiple senders and a single receiver and the broadcasting channel bc comprising one sender and multiple receivers a fundamental goal lies in examining how distinct nonclassical correlations achieved from multipartite quantum systems can enhance the effectiveness of the limited communication channels available to both senders and receivers in this endeavor we intend to uncover a deeper connection between quantum information theory and quantum thermodynamics while the intricate link between these domains has been highlighted by the work of szilard landauer and bennett our aim is to explore this connection within the quantum realm to its broadest extent with a specific focus on network communication scenarios in addition to introducing a novel avenue for quantifying and detecting quantum resources through experimentally measurable thermodynamic quantities this undertaking also offers insights into why quantum theory holds a special status among mathematically allowed models
challenges and innovative changes in research ethics reviews

trust in science and technology as well as the utility and acceptability of their innovative outcomes is crucially dependent on the ethical qualities of the research this is the reason why research projects are submitted to an ethical review although the existing ethics review infrastructure includes experienced members with expertise in traditional research this is not the case for new technologies and transformative research that result in new human rights such as digital rights thus there is a clear need for ethics committees to evolve in order to cover this gap and to be able to support innovation while embedding new human rights changer aims to promote changes in research ethics reviews that strengthen the capacities of researchers to incorporate ethical judgements in the project design and implementation and to support ethics committees to address new challenges posed by new technologies and new research practices changer will review current practices and ethics criteria will identify and discuss new challenges emerging from new technologies and from new research practices which are not sufficiently covered in the current review process will provide innovative training to ethics review experts and researchers and propose innovative approaches and tools to ethics review reform and new understandings to practice ethics by design supported by guidelines and a policy roadmap the changer interdisciplinary consortium has extensive and longstanding experiencebased expertise in research ethics reviews integrity oversight and human rights and is capable of providing novel solutions to the needs in ethics reviews
toward consolidation of germplasm and cell reversible drying through knowledge transfer

whynotdry will deepen our knowledge on reversible drying in cells and germplasm toward the development of a dry biobanking as an alternative to the current freezing in liquid nitrogen ln ln is expensive requires dedicated facilities and power supply and has a high co2 footprint whynotdry will achieve its aims through a multidisciplinary intersectoral international network of scientists that will i develop a dryingrehydration platform using naturally desiccationtolerant midge polypedilum vanderplanki pv11 cell lines ii identify the best combination of naturally occurring xeroprotectants xerodry from desiccationtolerant insect cell line and the best performing water subtraction platform iii to use the best xeroprotectants mix and the dryingrehydration protocol for mammalian cellsgermplasm vi develop a prototype for controlled dehydration of microvolumes of cell the ri activities leading to these aims will be carried out by knowhow sharing through staff exchanges between 3 eu academies 2 eu smes 2 international partners japan thailand outcomes of whynotdry will be incorporated into a cheap environmentally friendly and easy biobanking for biodiversity conservation assisted reproduction stem cellpersonalized medicine successful development of this technology will set the basis for a radically new green biobanking paradigm simplifying the maintenance and shipping practices in life sciences with enormous reduction in costs and carbon footprint moreover knowledge generated in whynotdry would be applicable to other fields such as agriculture environmental science food processing and the pharmaceutical industry where elective or enforced by climate change drying is dealt with finally whynotdry will empower young scientists with transferable skills ensuring career prospects in academiaindustry and strengthen the internationalsectorial network between disciplines boosting european excellence
fighting cancer with next generation oncolytic immunotherapy in ovarian head neck and lung cancers immune checkpoint response enabling adenovirus technology

tilt biotherapeutics is a clinicalstage biotechnology company developing novel gene therapies for cancer tilts lead asset tilt123 is an oncolytic adenovirus armed with two human cytokines tnf alpha and il2 tilt123 is now in several phase 1 clinical trials in europe the us and china the asset has been tailored to immunologically heat up cold tumors multiple antitumor mechanisms are activated direct immunogenic killing of cancer cells while sparing healthy cells release of tumor epitopes production of cytokines locally at the tumor and stimulation of patients own immune system to attack cancer this approach provides the tumor with presence of immune cells a prerequisite for immune checkpoint inhibitors icis to work and benefit patients the project objective is to provide a curative treatment option to patients with refractory cancer such as the ovarian head and neck or lung cancer and secure a global pharmaceutical customer to take tilt123 to the market
an innovative noncontact and harmless screening modality set to change the course of breast cancer detection and patient monitoring

female breast cancer is the most diagnosed cancer worldwide in 2020 the international agency for research on cancer estimated more than 226 million new cases of breast cancer early detection is crucial to survival recovery rates approach 90 when detected in early stages national populationbased cancer screening programmes in europe currently implement 3 standard imaging modalities mammography ultrasound and mri the downsides of these screening methods include ionising radiation high costs and high false positive rates in screening resultsour multidisciplinary consortium of 16 partners from 10 countries aims to contribute to eus mission on cancer and beating cancer plan by drastically improving the prevention diagnosis and monitoring of breast cancer while reducing the burden on women and female patients and their families health care professionals and others who are directly or indirectly affected by breast cancerthermobreast proposes a new solution for accurate harmless and noncontact screening equally applicable for all age groups and breast densities and capable of detecting precancerous states this riskfree screening technology recently patented by the project coordinator thermomind ltd can detect vascular anomalies and asymmetry caused by cancerous growth it combines innovative screening through multiple sensitive infrared sensors with advanced ai analysis of temporal dynamic thermal patterns through its patientcentred integrated diagnostics approach this project converges intelligent computer vision blood vessel extraction and tissue analysis with advanced information technology to deliver a medical class 1 device that will be validated in an international multicentre clinical study to enhance stakeholder participation thermobreast involves end users ssh experts and a patient organisation in the cocreation of the new screening solution and assesses its health and socioeconomic benefits as well as its cost effectiveness this action is part of the cancer mission cluster of projects on prevention including screening