Dragon09/odtu_chatbot huggingface dataset:
photonic system engineering with microcombs

optical frequency combs are fascinating photonic devices for realizing modern applications that rely on precision frequency synthesis and metrology today microcombs offer the prospect of attaining in a single chipscale formfactor an optical frequency comb with outstanding performance in terms of line spacing and bandwidth coverage with microcombs some proof of principle labbased systemlevel demonstrations have been realized but these make use of large bulk components and instrumentation that prevent the largescale deployment of this technology in massmarket applications the overall ambition of this doctoral network is to provide the scientific and training necessary to bridge the gap between proofofprinciple applications and deployment of this disruptive technology the network brings together experts from academia and industrial leaders in microresonator frequency combs heterogeneous integration packaging technology and nonlinear physics while covering a wealth of emerging applications from quantum information processing to biophotonics the collaborative science is embedded in a meaningful comprehensive and tailoredmade training program that covers crucial aspects in diversity digital science entrepreneurship and innovation this network will catalyze the career of 12 doctoral candidates who will pave the way for novel scientific endeavors and deploy this technology in massmarket applications from datacenter interconnects to lidar in selfdriving cars
targeting r2tptttwacmtor complex in ovarian cancer

ovarian cancer oc is the most lethal gynecological tumor and has an especially high impact in europe 70 of patients develop an advanced stage due to the lack of early diagnosis tools and chemotherapy resistance therefore a better understanding of altered molecular mechanisms driving oc progression is needed preliminary data from the host lab suggest that a complex formed by r2tptttwac upon glucose and glutamine depletion impairs mtor activation moreover the components of this complex are coexpressed in oc a disease influenced by mtor signaling and metabolic reprogramming thus our hypothesis is that wac regulates an mtor activation pathway that influences oc progression and response to chemotherapy and that targeting this complex is a potential therapeutic prospect for the treatment of oc in particular we propose to i establish the mechanism and role of the r2tptttwacmtor complex in oc and ii to identify new therapeutic strategies targeting this complex for the treatment of ocwe have envisioned this project as a diverse node of cancer signaling and protein experts with a predicted outcome highly transferable to society the translational character of this proposal from molecular mechanism to therapeutics relies on the integration of an interdisciplinary team formed by the host group proficiency in structural biology and my expertise in molecular biology and drug discovery together with scientific experts on experimental therapeutics and bioinformatics from the host institution and collaborators importantly i will have the opportunity to develop new professional skills by both scientific exchanges and specific courses and to participate in dissemination activities to translate our findings to the scientific community and society thus the msca fellowship will allow me to develop unique technical and transferable skills to help me progress in my career developmental plan and establish myself as a leader in cancer research in europe
ecosystems mapping and planning through open dialogue for wider cooperation across eu regions based on the entrepreneurial discovery

empowered by neia brings together a team of stakeholders from 7 eu countries 2 regional innovationdevelopment agencies and 5 business support organizations incubators and accelerators with he ambition to engage in a process of peer mutual learning and cooperation and support clean tech for sustainable development based on an indepth analysis of strengths weaknesses challenges and gaps in the ecosystems they represent the empowered by neia team members strive to bring together the members of the innovation ecosystems they represent as active stakeholders in bottomup policymaking activities tailored to their needs through an entrepreneurial discovery process we aim to stimulate a participative process that will allow to identify the best innovation opportunities in each ecosystem and align them with the ones of the peers the results of the entrepreneurial discovery run locally by each partner will represent the foundation of action plans elaborated according to the european entrepreneurial region approach to strengthen the collaboration between the regional european innovation ecosystems these plans will be back up with collaboration and project ideas for which public and private funding will be sought through the involvement of the empowered by neia consortium partners in landmark initiatives such as the european association of development agencies eurada the vanguard initiative or the activities of the european entrepreneurial region initiative we will connect with external peers to expand the learning and cooperation process disseminate our activities and increase their impacts
theory of tone

tonal languages are no longer perceived as exotic according to modern concepts about 5060 of the worlds languages are tonal however the main shortcoming of the majority of research dedicated to tones consists in a narrow panorama of research it is most often limited either to the description of the tonal system of a certain language or to a particular problem like correlation of tone and accent etc the goal of the project is twofold a to prove that any tonal system can be classified into one of the presumably four categories and b typical trends of change of these systems in diachronic perspective are movements from one category to another according to rules that have to be identified it will be done on the basis of rich language data the project covers all major areas of localization of tonal languages within a fiveyear project it is impossible to explore all the tonal languages of the world thus a balanced sample of 150200 languages will be carefully studied this sample takes into account the language family area of distribution and other relevant parameters including information on language structure characteristics of the tonal system functions of tone tonal density index this ambitious goal can be achieved through the participation of leading specialists in tonal languages like larry hyman and other prominent tonologists the present project is a breakthrough as it will make possible to discover substantiate indepth correlations between suprasegmental characteristics of a language correlations between suprasegmental system and other parameters such as genetic affiliation areal distribution or morphological structure the adopting the terminological system that can be applied to any tonal system of any language will lead the research team to an adequate comparison of tonal systems special attention will be paid to intermediate types the study of languages will combine typological genetic and areal approaches
advancing nanoscale devices based on solidstate nanochannels ssns modified with bioactive building blocks

nanobiosens seeks to expand the potential of solidstate nanochannels ssns in the field of electrochemical sensing and the study of phenomena at nanoscale ssns have garnered significant attention among researchers due to their promising applications inspired by the sophisticated transport mechanisms found in biological channels in nature ssns offer precise control over ion transport ion transport across ssns is controlled by the geometry and physicochemical properties of the surface thus highly selective and sensitive transport relies on controlling the internal chemistry and architecture of the channel ssns offer in addition new avenues to diverse device with nanofluidic and sensing applications in this project we endeavor the creation of ssnbased devices for biosensing while simultaneously delving into fundamental studies of building block behavior in nanoconfinement to achieve these objectives i will develop and test a novel dualsignal setup that combines electrochemical and iontronic measurements in ssns while pure electrochemical sensing faces challenges related to sensitivity cost efficiency and complexity iontronic sensing enables the adjustment of ion transport properties in ssns enhancing the performance of the sensor leveraging ssns exceptional sensitivity we will pioneer highly sensitive enzymebased biosensors the innovative dualsignal sensing mechanism will harvest both the information of ec sensing and the high sensitivity of iontronic sensing it will offer fundamental studies on building block performance within nanoscale confinement providing invaluable insights into their behavior such studies are crucial for refining the precision and effectiveness of nanoscale architectures and their applications thus nanobiosens extends beyond immediate impact seeking to push the boundaries of ssn exploring novel methods and mechanisms for future advancements and applications
text and idea of aristotles science of living things

text and idea of aristotles science of living things tida pursues two objectives one philosophical the other philological both of which can only be achieved in tandem subjecting aristotles treatise on the soul the de anima da and related treatises to a new and comprehensive philosophical interpretation while making available the original greek texts in a way that complies with the standards of contemporary textual criticism philosophically the aim is to replace the interpretive approach that governed philosophical discussions around the da for the past 5 decades with a more coherent and philosophically more informative interpretation according to the received approach the argument of the da falls into the domain of philosophy of mind this assumption fruitful though it was for our understanding of many of the das arguments obfuscates the main aim and purpose of the treatise tida shows how the da is not concerned with the philosophy of mind as such but with defining the first principle of the science of living things we show how the da divides explanatory labour with the other treatises pertaining to that science and most importantly what the resulting scientific theory of living things has to say about the issues of the philosophy of mind philologically the goal is to produce reliable critical editions of the relevant texts print and digital which we astounding as it might seem still do not possess as the constitution of the texts will depend on the philosophical evaluation of alternative manuscript readings only the closest collaboration between textual critics and philosophers will yield progress there is reason to expect improved original texts and a genuinely new and more informative perspective on aristotle on the mind in effect tida consists in a fiveyear interdisciplinary research team designed to give future philosophical and philological work on aristotles science of living things a new and lasting foundation
understanding the hostenvironmental interactions across the lifespan determining lung function trajectories and copd

chronic obstructive pulmonary disease copd has been traditionally understood as a selfinflicted disease caused by tobacco smoking occurring in old individuals over the past few years however our group and others have proposed that the pathogenesis of copd goes beyond smoking and that there is a range of lung function trajectories through life trajectome some of them have roots in early life and can lead to copd cardiovascular and metabolic morbidity as well as premature death while others are associated with healthy ageing here i propose that detrimental gene g and environment e interactions occurring early in life t constitute a first injury hit that alters the normal lung developmental program and modify the pace of normal lung aging by reducing the resilience of the lungs to future gxext interactions accordingly lifelong gxext interactions determine the individual trajectome and eventually the occurrence of copd and associated multimorbidity predictcopd aims to identify the interactions and mechanisms that determine which individuals will develop copd and multimorbidty at some point of their life the specific aims are 1 to identify the lifelong environmental and host risk factors associated with the trajectome copd and multimorbidity 2 to use a novel liquid biopsy method to identify biological factors driving the trajectome copd and multimorbidity 3 to identify clinically relevant preventive andor early therapeutic targets integrating the results from aims 1 and 2 with novel analytical approaches and 4 to validate findings both in vitro and in other available cohorts the project will leverage from several available population and copd patient studies with available clinical data and biological samples the results of predictcopd have the potential to 1 promote healthy ageing by preventing and eventually eradicate copd and associated multimorbidity and 2 change copd treatment from palliative to causal
transmission over channels with insertions and deletions

insertions and deletions represent perhaps the most challenging impairments exhibited by communication channels in a wide range of applications from recording systems and covert communications to dna storage while tremendous progress has been made in determining the ultimate limits of communication using informationtheoretic tools as well as in designing and implementing signaling solutions for various channel models with practical significance for the case of insertiondeletion channels even the simple scenarios are not fully understood for instance we do even not know the capacity of the basic independent and identically distributed binary deletion channel trancids will take on the monumental challenge of conquering the insertions and deletions by developing precise theoretical limits of communication and by designing explicit and implementable coding solutions approaching these limits specifically trancids will 1 establish with precision the capacity of basic deletioninsertion channels and obtain tight upper and lower bounds on the capacities of more sophisticated channel models encountered in practice including the effects of noise and interference 2 formulate and explore wireless communication problems with insertions and deletions including multiinput and multioutput systems as well as different multiuser communications settings 3 develop explicit and implementable channel coding solutions for a variety of channel models with insertions and deletions of practical importance 4 address the channel capacity and code design problems for channels with additional impairments such as permutations as motivated by invivo dna storage applications trancids will highly impact different emerging applications such as dna storage and beyond 5g wireless communications furthermore the findings will help facilitate the development of dna computing technologies of the future
singlesource collaborative publishing

book publishing involves many stakeholders and a complex set of inflexible tools and formats current workflows are inefficient because authors and editors cannot make changes directly to the content once it has been laid out they are costly because creating different output formats such as pdf epub or html requires manual labor finally new requirements such as the european directive on accessibility incur additional costs and delays the goal of the onepub poc project is to demonstrate the feasibility and value of a book production workflow based on a set of collaborative editing tools and a single document source representing the ground truth of the book content and layout the editing tools will be tailored to the needs of each stakeholder eg author editor or typesetter and will feature innovative interaction techniques from the pis erc project onethe project will focus on textbooks and academic publications as its testbed because they feature some of the most stringent constraints in terms of content types and content layout they also run on tight deadlines emphasizing the need for an efficient processonepub will define a unified format for the document source create several collaborative document editors and develop an open and extensible architecture so that new editors and addons can be added to the workflow together these developments will set the stage for a new ecosystem for the publishing industry with a levelplaying field where software companies can provide components while publishers and their service contractors can decide which components to use for their workflows
guided by a sixth sense unravelling magnetic migration in monarch butterflies

each fall millions of monarch butterflies take off from to migrate over up to 5000 km to their overwintering sites during their long journey they employ a wide range of cues to maintain their southerly flight direction while monarch butterflies have been shown to be sensitive to magnetic information its role during migration remains elusive in this project i will test the role of the earths magnetic field during migration using a doublewrapped 3dhelmoltz coil i will study whether butterflies can use magnetic cues as a compass to keep their migratory direction magnetic compass in addition by virtually displacing migratory monarch butterflies i will investigate whether they can also determine a specific goal location or even their own global position based on magnetic cues magnetic mapi will next study the neural coding of magnetic information in the monarch brain i will target candidate compass neurons within the navigation network of the central complex using multichannel tetrode recordings i specifically aim to obtain recordings from the headdirection neurons during magnetic field manipulation i will test how the different magnetic field components are encoded in central complex neurons in this way i aim to obtain a detailed picture of the neuronal correlate for magnetic orientationbesides compass or map magnetic cues could also be used for compass calibration while time compensation is a crucial aspect of a navigation how it is established at a neuronal level remains elusive i will investigate the role of the magnetic field as a geostable reference system for compass calibration to do so i will combine magnetic manipulations and a simulated sun stimulus to create cueconflicts i will use extracellular tetrode recordings in tethered navigating butterflies to investigate the influence of cueconflicts on the neural coding i aim to unravel how magnetic and celestial cues are integrated to create a timecompensated sun compass
hybrid humanai decision support for enhanced human empowerment in dynamic situations

humaine will research develop validate and promote a novel operating system for humanai collaboration which will enable the development of advanced decision making applications in dynamic unstructured environments in different industrial sectors the humaine os will empower ai solution integrators to implement humanai collaboration systems that outperform ai systems and humans when working in isolation humaines developments will be integrated into a single os platform which will coordinate four interwind components offering active learning al neurosymbolic learning swarm learning sl as well explainable ai xai capabilities these advanced ai paradigms are ideal for exploiting true humanai collaboration since in each of them the worker is the key actor with complete control and understanding of the performed operations al enables the development of effective humanintheloop systems that involve humans when ai faces increased uncertainty neurosymbolic learning combines dl with semantics and rules to complete highly complex tasks with high accuracy while requiring considerably less training data than current ai models advanced xai models will be made available providing explanations of models predictions while considering the global context instead of just analysing the feature importance of a single ai model humaines xai will provide guidance to humans to enable the timely optimisation of al and sl models where human participants provide feedback dynamically as well as finetuning of neurosymbolic models the platform will handle various types of structured and unstructured data including inputs from humans that will be semantically correlated through ontologies knowledge graphs and semantic interoperability humaine will complement its platform with complementary resources eg training and will be build a vibrant community of interested parties around it to drive exploitation and wider use of the projects results
greenhouses as vital landscapes sustainability relationality and the future of food

greenhouses play a crucial role in europe ensuring the production of affordable vegetables but they are under great pressure to change the eu is encouraging consumers to move towards a plantbased diet necessitating an increase in horticultural productivity simultaneously the uns 2030 sustainable development goals include reducing land degradation and biodiversity loss such pressures including requirements to reduce chemical use in the netherlands and water use in spain and social unrest about the exploitation of migrant workers challenge the industrial model of production using ethnographic methods vitalgreenhouse will examine how greenhouse growers workers scientists and environmental community groups are experimenting with sustainability in spain and the netherlands both leaders in intensive greenhouse use our team will study how different versions of sustainability are performed in the various and often competing practices of growing food handling multispecies relations and addressing workers rights the work is divided into four subprojects 1 studying the multispecies relations of growers pickers and other nonhuman laborers such as pollinator bees 2 investigating how growers and workers are adapting to or resisting climateintelligent agriculture a recent iteration of sustainability 3 examining how greenhouses spark and sustain labour mobilities creating novel ways of belonging forged through working in the greenhouse and 4 historicising and contextualising current sustainability practices in the european greenhouse complex vitalgreenhouse will develop an innovative analytical framework that conceives of sustainability as a relational practice and theorises greenhouses as a vital landscapes combining political ecology science and technology studies and decolonial thought vitalgreenhouse will produce a new understanding of sustainability for environmental anthropology