Dragon09/odtu_chatbot huggingface dataset:
next generation ultrahighspeed microwave photonic integrated circuits using advance hybrid integration

in pattern will worlds first process design kit pdk for microwave photonics at ultrahigh frequencies above 100 ghz as well as bringing new functionalities into pic such as magnetooptics isolators and acousto optics modulators aom patterns approach to ultrahigh frequencies is holistic and includes all the aspects such as design and simulation generation detestation modulation and packaging to achieve this goal we propose a massive hybrid integration of several different pic platforms such as inp and lnoi but also including new materials such as yttrium iron garnet yig we also develop cointegration of electronic sige chips with pics which especially a necessity in ultrahigh speeds lnoi is of the most promising emerging materials for pics that comprises a unique set of interesting optical properties a high electooptic coefficient a high intrinsic 2ndorder nonlinearity and a large transparency window which makes it ideal for electronics manipulation of light at many wavelengths eo modulation inp is an ideal platform for generation and detection of light and yig is a known magnetooptics material if put together truly novel and advanced functionalities and opportunities arise in addition in pattern we developed packaging solutions and for such high frequencies which one of the main barriers in this field moreover we also develop software expertise for design automation eg rf signal routing and endtoend circuit simulation and design which is extremely challenging at these frequencies we also demonstrate the capabilities of the platform in 6 different applicationoriented prototypesto achieve these objectives pattern put together the expertise of 10 well know smes rtos and industrial players to achieve these objectives in 48 months project once developed pattern will pave the way for the new generation of advanced pic products in wide range of applications from telecom 5g6g to quantum technologies lidar and sensing
coastal observation advances leveraging space technology services

coastal zones are critical regions accommodating a significant proportion of the global population and hosting diverse ecosystems that provide essential services coastal blue carbon ecosystems such as mangroves seagrasses and salt marshes play a crucial role in carbon sequestration and storage biodiversity and coastal protection despite their socioeconomic and biological importance they face numerous threats from human activities and climate change necessitating their conservation and management mapping modelling and monitoring coastal zones using earth observation eo data is essential for this task it needs to consider the complex coastal dynamics past and future change scenarios and the interaction between blue carbon and the coastal zone dynamics by integrating eo data advanced modelling techniques and detailed processbased morphodynamic models coasts aims to develop a downstream service for coastal observation with a focus on blue carbon this service utilizing copernicus marine and other initiatives will provide govern stakeholders and coastal planning with relevant information for developing coastal management strategies including the assessment of blue carbon habitats and their environmental services further coasts will develop innovative methods and comprehensive analyses to create new business models related to emergent blue carbon markets and will offer new international income sources for countries with blue carbon ecosystem presence coasts will initially focus on pilot sites in germany jersey and the maldives where govern customers have a demand and support the project the learnings from these examples will form a blueprint for broader application in other regions in response to a growing global need supported by an interdisciplinary team and strong links with governmental institutions the coasts project presents an innovative scaleable and sustainable approach to coastal conservation and blue carbon management
noninvasive computational immunohistochemical staining based on deep learning and multimodal imaging

in most european countries the diagnosis of cancer is achieved by examination of haematoxylineosin he staining by an experienced pathologist nevertheless several other diagnostic approaches exist eg immunohistochemical staining which are not applied routinely for all cases due to their technical complexity duration and cost therefore an important unmet medical need for fast noninvasive and labelfree immunohistochemical staining based on molecular imaging without laborious sample treatment exists this demanding challenge will be tackled in stainit using a noninvasive labelfree measurement technique called multimodal imaging eg the combination of coherent antistokes raman scattering second harmonic generation and twophotonexcited fluorescence the multimodal images will be analysed using deep learning approaches such as convolution neural networks cnns these cnns are utilized to mimic immunohistochemical stainings cnns are neural networks that learn the feature representation of the data which is optimally suited to model a specific immunohistochemical staining in stainit the staining models will be developed along with the methods to quantitatively understand the nonlinear behaviour of the cnns with the envisioned approximation approaches for cnns these models no longer act as black box systems and a quantification of tissue changes associated with the staining models can be achieved for the very first time stainit will develop a labelfree noninvasive labourinexpensive and fast computational immunohistochemical staining which can be easily implemented into clinical routine yielding increased diagnostic reliability and a better understanding of disease pathogenesis a fast test of the antigen ki67 in an intraoperative frozen section consultation situation or the use of collagen iv as a quality control marker of tissueengineered medicines are some of the exciting application possibilities of such staining model
anosognosia and delusions in the diseased brain

why is the diseased human brain able to produce false beliefs that persist despite evidence to the contrary unawareness of neurological disturbances anosognosia and delusions are examples of such false beliefs both have productive narrative features both have been independently linked to processes involved in selfreflection metamemory and errormonitoring despite their phenomenological similarities the research investigating their mechanisms has progressed independently unawired will provide the first indepth investigation of anosognosia and delusions in combination to test the hypothesis that they share common brain mechanisms although these symptoms impact significantly on a range of brain disorders the proposal focuses on alzheimers disease ad in which the difference between patients who show the most severe form of these symptoms and patients who never present them is striking yet largely unexplained in particular it is not known whether these symptoms represent a response of the spared brain to the damage depending on preexisting vulnerability or resilience or are a consequence of the damage itself depending on type localisation and severity of pathology by combining advanced imaging with experimental paradigms and extended clinical and biomarker characterisation unawired will 1 establish whether anosognosia and delusions define a specific clinical subtype in ad 2 determine if they are associated with premorbid personality and cognitive abilities 3 identify the brain networks specifically altered in the anosognosiadelusion ad subtype4test if anosognosia is associated with an imbalance in the brain neurotransmitter dopamineunawired will deliver a new framework to study the interplay between the spared and damaged brain in the origin of productive symptoms across neurological diseases by doing so it will open a window towards a better understanding of the uniquely human abilities of selfreflection and consciousness
oscars open science clusters action for research and society

oscars open science clusters action for research and societythe oscars project brings together esfri and other worldclass research infrastructures organised in five science clusters envrifair environmental science eosclife life science escape astronomy and particle physics panosc neutron and light source science and sshoc social science and humanities that have cooperated over the last four years to rise the efficiency and productivity of researchers by providing open data services and infrastructures for discovering accessing and reusing data the proposed oscars project aims at combining individual clusterbased key activities and new shared strategic pathways towards two major objectives a consolidating achievements from the five h2020 infraeosc20180104 projects into lasting interdisciplinary services and working practices
design rules for efficient photogeneration in metal oxides

photoelectrochemical pec water splitting is an attractive route for green hydrogen production despite nearly half a century of research efforts no material has successfully met the stringent requirements for a photoelectrode material the light harvesting semiconductor within the pec cell metaloxides are widely viewed as the most promising photoelectrode materials for their exceptional stability in aqueous electrolytes but those with suitable band gaps for visible light absorption typically have open d shell configurations and suffer from low photoconversion efficiencies i hypothesize that the underperformance of such materials is related to their electronic configuration which reduces the photogeneration yield of mobile charge carriers an overlooked yet critical loss mechanism in metaloxides thus unlike conventional semiconductors where all absorbed photons generate electrons and holes in metaloxides with open d shell configuration many of the photons give rise to localized electronic transitions that do not contribute to the photocurrent in addition polaronic transport and charge carrier recombination reduce the charge carrier collection efficiency dream will address these challenges and provide a leap forward in understanding the photogeneration processes in metaloxide photoelectrodes and their effect on photoconversion efficiency to achieve these goals we will couple systematic control of crystallographic structure d orbital occupancy and local cation environment using heteroepitaxial thin film growth together with wavelength and temperatureresolved characterization of the photogeneration yield spectrum the knowledge gained by these fundamental investigations will lead to new design rules which we will employ to engineer new metaloxides with near unity photogeneration yield and integrate them into novel device architectures enabling highly efficient pecpv tandem cells for unassisted solar water splitting
neuromophic systems based on memristor and ferroelectric devices for computing applications

artificial neural networks anns are simplified models and hardware that simulate how the brain of living beings especially humans process information anns are inspired by the nervous system and biological behavior creating a layered interconnection system of artificial neurons that collaborate to process input data and generate output anns differ from other ai models in having the ability to learn automatically machine learning this technology has enormous current impact and potential for future applications just to mention a few ones autonomous vehicles renewable energy economy and financial predictions computer visions and disruptive medicine and health care services in the last decade anns have become a very popular topic but the technology itself has been around for many decades with several problems yet to be solved for example current computer systems are highly inadequate in terms of data processing storage and transmission aspects related to energy consumption are also an unsolved problem where the rational use of energy and natural resources is a fundamental objective of global sustainability nemerfec aims to realize novel anns through the development of hardware based on memristive and ferroelectric material systems such thin films of binary and complex oxides are to be deposited by physical ablation methods such as pld and sputtering with a high degree of control during deposition advanced characterization techniques microfabrication and nanofabrication of devices will be performed at the clean room facilities of the aragon nanoscience and materials institute inmacsic to obtain anns at nanometric scales and with an ultrafast response time the final anns will be implemented in the analysis of thermal images in hyperthermia processes with magnetic nanoparticles at the nano scale biomagnetics company during the nonacademic placement period these possible results will be completely novel in this type of application
grapheneenzymebased nanohybrid agent to overcome environmental and sustainability thresholds in water management systems

biofouling on surfaces is one of the most pressing global threats exacerbated by the world growing population and subsequent industrial activities as well as climate change it affects all societal infrastructures including maritime operations water management and foodbeverage systems the main problem underlying all these infrastructures is the colonisation of microorganisms on watercontact surfaces forming biofilms biofilms can harbour microbial populations of diseasecausing pathogens which are associated with waterborne disease outbreaks that occur every year worldwide and their disinfection is currently a critical and challenging process biofilms are also associated with microbially influenced corrosion mic which is estimated to affect up to 20 of corrosion in water management systems costing billions of dollars only for rehabilitation hitherto the most effective antibiofouling strategies rely on the release of toxic and persistent bioactive agents remaining ineffective to prevent biofilm formation on surfaces under the current demand and environmental guidelines under bionanoact a new bioactive bionanohybrid agent generated by the insitu synthesis of metal nanoparticles in enzymegrafted biographene matrices will be developed and immobilised in polymeric formulations to produce novel nanocomposite coatings with longlasting antifouling and antimic protective effects on surfaces these multifunctional biobased nanomaterials will overcome current limitations in biofouling mitigation and enable scientific breakthroughs particularly in synthesis and grafting methodologies as well as in the interaction between biofilmsmart material and engineered waterborne systems this project will also bring together researchers and industry professionals working on stateoftheart strategies for biofouling mitigation and mic that will provide interdisciplinary training and a solid platform for knowledge transfer to the msca researcher
cytohemocompatible magnetic hybrid nps made of iron oxidesilver sulfide quantum dots with luminescence in the nearinfrared region for combinational therapy of peritoneal metastasis

peritoneal metastasis pm is considered as the terminal stage of metastatic colon cancer with still poor median survival rate even with the best recent chemotherapy chem treatment suggesting the need for advanced methods to assist with the early diagnosis and treatment however the newest methods combine cytoreductive surgery with hyperthermic intraperitoneal chem hipec which uses mild hyperthermia hyp by circulation of a hot fluid to boost the diffusion and cytotoxic effect of drugs a recent development in patients with unresectable pm is pressurized intraperitoneal aerosol chem pipac that combines a diagnostic laparoscopy with locoregional administration of chem as an aerosol nonselective biodistribution low bioavailability high drug concentrations limited drug circulation time and various sideeffects limit the utilisation of hipec and pipac innovative drug delivery system with the controlled drug release at tumour site can enhance the therapeutic efficacy utilisation of nanoparticles nps as carriers to deliver drugs with the possibility of tagging them with targeting agents will overcome the offsite toxicity cytohemocompatible magnetic hybrid nps silver sulphideiron oxide with luminescence in the nearinfrared region for combinational therapy of peritoneal metastasis sante project aims to develop multimodal therapy approach for diagnosis and treatment of pm it intends to enhance the efficacy of pm treatment using a combination of image guided remotely activated nanohyp coupled with targeted chem tumour targeted ag2s will allow preoperative detection of microscopic or residual tumours to improve resection before chemhyp iron oxide targeting agentcetuximab and the chemotherapeutic drugcisplatin are all clinically used for the treatment of various type of cancers the result of this fellowship will enable scientists in the pm field to translate the novel diagnostic and therapeutic methods into clinical practice and marketa
international cooperation of high containment research infrastructures from epidemic preparedness to response

emerging infectious diseases eid do not respect borders they rank as global catastrophic risks for humanity along with climate change and biodiversity loss the covid19 pandemic showed how coordination of global research through cooperation and sharing of data and expertise are crucial for efficient and effective preparedness to eids and vital for a rapid response nevertheless there are still major challenges limiting global cooperation among high containment laboratories hcls hcls are critical infrastructures for the development of medical countermeasures eg vaccines and therapeutics against high consequence pathogens in order to fulfil its role and given the global threat of eids the european research infrastructure on highly pathogenic agents erinha together with its partners proposes to establish and reinforce interactions with hcl research infrastructures ri worldwide to strengthen pandemic preparedness and response capacities interceptor international cooperation of high containment research infrastructures from epidemic preparedness to response a consortium with key hcls from europe and across the world will focus on access provision to hcls enhancement of the human capital of hcl including in biorisk management critical resources sharing harmonisation and interoperability the proposed actions will help ensure broader access to stateoftheart hc facilities while respecting the necessary biosecurity and biosafety constraints and promote the establishment of a sustainable global network of hc ris by expanding access to hc ris strengthening the human capital base promoting sharing of knowledge skills and experience and providing opportunities for common training programmes and staff exchanges interceptor will reinforce the next generation of hcl researchers and facility managers and extend the opportunities for access to hcls required to push the boundaries of science and innovation in the field of eids
reversing vaccine hyporesponsiveness

prevention of infectious diseases through vaccination is one of the greatest achievements of medicine yet there is growing realisation that vaccine immunogenicity and efficacy varies greatly across populations in high versus lowmiddle income countries lmic and in urban versus rural areas within one country for example whereas vaccination of volunteers in europe with attenuated malaria vaccine can result in 100 protection the efficacy drops to only 29 when tested in africa where it is needed most other vaccines such as rotavirus bcg yellow fever and ebola show similar trends in either immunogenicity or efficacy it is my ambition to take on the challenge of understanding the mechanisms underlying vaccine hyporesponsiveness across populations and find ways to reverse iti hypothesize that the variation in the immunological network shaped by exposure to microorganisms and parasites as well as by cellular metabolic state of populations residing in distinct environmental conditions underlies vaccine hyporesponsiveness and can be reversed by immunological and metabolic interventions to address this i will compare unique cohorts from lmic and europe using single cell technologies to understand the immunological and metabolic networks that govern innate and adaptive immune responses not only blood but also secondary lymphoid organs will be studied to gain critical information on key cellcell interactions within germinal centers and how they are influenced by cells beyond b and t cells discovering key pathways underlying hyporesponsiveness i will take advantage of increasing availability of clinically approved modulatory compounds to target these pathways to improve vaccine responses in our in vitro models i will also perform a proof of concept clinical trial to establish a pipeline for translating the fundamental insights gained to human testing and pave the way to new horizons for vaccines to show their full potential worldwide
microbiomedrivers of liver fibrosis

liver fibrosis is increasing in prevalence in many western populations mainly due to alcoholic liver disease and nonalcoholic fatty liver disease and has a major burden on care provision as to date there is no specific intervention to reverse fibrosis one of the factors that could regulate liver fibrosis is the intestinal microbiome as various microbial derived compounds reach the liver through the portal vein and act on the liver cells including stellate and kupffer cells the main drivers of liver fibrosis my hypothesis is that the hepatic stellate cells phenotype could be driven by the microbiome and microbial derived metabolites the key objective is to gain comprehensive understanding on how the microbiome modifies liver homoeostasis and contribute to liver fibrosis development using analysis of the network perturbation in disease coupled with microbiome experimental techniques to achieve this i plan to answer three main questions 1 which microbiome states and microbiome derived metabolite modulate fibrosis 2 how does these microbiome states and metabolites changes the hepatic stellate cells phenotype at a cellular and spatial level 3 which are the mechanisms by which the microbiome modulates liver fibrosis this will allow characterizing in depth and dissecting the molecular mechanisms of fibrosis and the contribution of microbiome and microbial associated products furthermore identification of potential factors affecting the course of the disease may lead to potential assisting therapies involving the microbiome and at term leading to an improvement in the prognostic and management of patients with liver fibrosisthe marie skodowskacurie fellowship is an important point in my career because it will allow me to ask relevant and innovative questions about hostmicrobe interactions learn new approaches and transition from being a physician to an early career physicianscientist and a research group leader