Dragon09/odtu_chatbot huggingface dataset:
temporal dependence of enhancer function

during vertebrate development genes are regulated by distal regulatory elements presumably via physical contacts between enhancers and transcription start sites alterations in enhancer sequences andor their interactions with gene promoters can perturb gene expression leading to developmental disorders and cancers which argues for their pivotal role in transcription conversely enhancerpromoter contacts can also be uncoupled from gene activation during developmental transitions and in single cells where they are highly heterogeneous thus the relationship between enhancerpromoter interactions and transcription is frequently indirect and the mechanisms that dictate when promoterenhancer contacts can result in gene expression differences remain unknown the core hypothesis of this proposal is that it is the timing of promoterenhancer communication that instructs gene activation aim1 will examine whether and how the precise timing of enhancerpromoter interactions contributes to transcription my group will determine which molecular mechanisms during transcriptional activation are regulated by enhancers contacting their target genes at different time points during embryonic stem cell differentiationaim2 will investigate how present and preceding enhancerpromoter contacts relate to transcriptional activity and transcription factor binding in single cells my group will develop a genomic approach to trace the memory of preceding interactions at gene regulatory elements thus adding a novel temporal dimension to current singlecell methods by longitudinally combining cuttingedge genomic singlecell and activity perturbation assays my group will uncover how genes integrate regulatory inputs from several enhancers and assess how the timing of genome folding mechanistically contributes to this process this research plan will newly elucidate temporality as a powerful feature that shapes the regulatory potential of enhancers and promoters
producing the next generation of hybrid animalfree cheeses

nutropy is a french startup that develops the next generation of dairy and cheese alternatives we produce bioidentical milk ingredients proteins and fatty acids to develop premium cheese alternatives that taste as good as conventional cheese but are more sustainable healthier and better for the animals this project is dedicated to the development of a new line of hybrid animalfree cheese alternatives containing pulses
joint wireless communication and sensing by holographic surface transceivers

as the standardization of 5g wireless networks progresses the research community has started focusing on what 6g will be motivated by the need of ensuring high datarates while at the same time saving spectrum a major technology that has been proposed for 6g is the integration of communication and sensing services in the same infrastructure this enables wireless networks to perceive the surrounding environments triggering new services and leading to a more efficient use of resources the integrate project focuses on the theoretical algorithmic and architectural foundations of integrated communication and sensing networks developing the first open access networklevel simulator for joint communication and sensing to this end a new implementation of wireless transceiver is proposed which leverages the use of reconfigurable holographic surfaces and allows the integration of communication and sensing with remarkable performance while at the same time reducing the energy consumption specifically integrate will 1 develop reconfigurable holographic surfaces capable of supporting joint communication and sensing tasks and that can be integrated in wireless transceivers with minimal cost and energy requirements 2 characterize the fundamental performance limits of integrated communication and sensing networks developing an algorithmic framework and protocol suite to approach these limits 3 build the first open access software simulation platform for joint communication and sensing networks
tuning brain fate through modulation of chromatin remodelling

the mammalian swisnf chromatin remodellers the baf complexes are critical regulators of gene expression by modulating the accessibility of regulatory regions especially of cell identity genes their importance for cellular maintenance and differentiation is emphasised by the fact that they are frequently associated with disease mutations in genes encoding baf subunits are found in over 20 of cancers and are causative for neurodevelopmental disorders ndd the prevalence for specific ndd with unique clinical features depends on the mutant subunit the molecular changes leading to the disease phenotypes are largely unresolved the functions of baf complexes and specific subunits during human brain development are also still unclear switchfate thus aims to systematically identify the role of individual baf subunits and their mutations in brain development and abnormalities to this end isogenic wild type mutant and engineered human induced pluripotent stem cell hipscderived cerebral organoids will be used in combination with various bulk and singlecell epigenomics and proteomics tools switchfate will investigate gene regulatory mechanisms altered during brain development with crisprcasbased lossoffunction screens for all baf subunits using protein degradation tools targeting specific baf subunits switchfate will pinpoint vulnerable processes and adaptation mechanisms in addition cell type and baf subtypespecific composition interaction partners and target sites along brain development will be mapped to decipher bafdependent gene regulatory networks finally the molecular changes in baf mutationinduced ndd that cause the phenotypic changes in patients will be examined and conserved mechanisms across different genotypes will be deciphered using patientderived hipsc thus switchfate will decode the regulatory functions of baf complexes in the context of cell fate decisions in development and disease paving the way for new therapeutics
stepping up scientific excellence and innovation capacity for climateresilient crop improvement and production

the cropinno establishes collaboration network between institut za ratarstvo i povrtarstvo institut od nacionalnog znaaja za republiku srbiju ifvcns novi sad serbia and internationallyrecognized research institutions from spain csicias cordoba italy unipd padova and germany fzj juelich and uros rostock ifvcns is the national institute of the republic of serbia and worldwide recognized institution in plant breeding however it still lacks in technology and innovation capacity in multiomics and modern phenotyping as well as in international visibility and project management and administration skillsthe main objective of cropinno project is to step up and stimulate scientific excellence and innovation capacity of ifvcns in the field of climatesmart crop improvement and production and enhance its ability to respond and create innovative solutions for the challenges that agriculture faces climate changes and need to feed the increasing population the other cropinno objectives are strengthening of the research management and administration skills of the ifvcns and creating the conditions for positioning of ifvcns as a regional hub of ri in the area of agriculture and creation of climate crops centre these objectives will be achieved through a set of training networking and dissemination activities including shortterm scientific missions workshops international summer schools national and international conferences as well as field days the expected impacts of croppino include improved excellence capacity enhanced strategic networking activities raised reputation research profile and attractiveness of ifvcns and the research profile of its staff strengthened research management capacities and administrative skills of ifvcns staff as well as improved creativity supported by the development of new research activities and collaborations and increased mobility of qualified scientists
greens a training programme on 5rs implementation in the design manufacturing and application of micro and nanorobotic platforms

micro and nanoscale robotic platforms have captured the attention of researchers due to their remarkable ability to perform tailored tasks with unparalleled precision and minimal invasiveness these robots hold great promise with the potential to revolutionize fields ranging from biomedicine to environmental applications from catalytic to externally actuated robots ie magnetic light these robots offer the possibility of targeted drug delivery and enhanced reactivity due to their autonomous motion moreover the recent interest in the collective behavior of micro and nanorobots as swarms has gone handinhand with the implementation of degradable materials to ensure its later removal from the body currently the main focus in the field relies on the design fabrication and implementation of such robots with special emphasis on achieving proper delivery manipulation and final automation of large quantities of them in addition it is also important to explore costefficient and massproduction fabrication techniques to ensure that micro and nanorobots can be manufactured and deployed at scale however one aspect that has not received enough attention is the waste management cycle associated with the fabrication and use of these robots in the greens project we aim to implement for the first time the 5r reduce recycle rethink repair and reuse principle from the manufacturing to the final implementation and removal of nanomicro robotic platforms always accounting for the sustainability of the overall process to minimize the impact of fabricatingapplying them to the environment this initiative is aligned with the sustainable development goals established by the european comission ec and is of great importance to the environmental action program from the ec
active tripletmediator matrices for efficient solidstate triplettriplet annihilation photon upconversion devices

solar irradiation offers the possibility of clean and renewable energy worldwide one major challenge for solar energy conversion is the uncollected and wasted energy from the solar spectrum photons with energy lower than the bandgap of photovoltaic materials are lost a mere 1 utilization of low bandgap photons in todays solar energy installations would result in an additional 3 gw produced capacity equivalent to 5 nuclear power plants triplettriplet annihilation upconversion ttauc provides the possibility to convert two photons of low energy to one of high energy even at low irradiation intensity this allows the two unused photons otherwise penetrating the photovoltaic to be transformed into one useable photon the development of efficient ttauc systems compatible to solar energy harvesting devices is therefore of pivotal importance this project aims at fabricating a material that enables efficient solar energy harvesting at low photon energies specifically we will do this through solid state triplettriplet annihilation upconversion i will employ novel organometallic sensitizers that allow for low energy harvesting these sensitizers will be incorporated into an active host matrix that replaces molecular diffusion with triplet exciton diffusion this is a novel realisation of energy transfer in the solid state and will circumvent current limitations in solid state upconversion this will yield an efficient ttauc solid state material that can be applied to devices by fulfilling these tasks this research project will ultimately contribute to a new strategy for enhancement of solar energy conversion
european doctoral network for safe and sustainable by design electromagnetic shielding material

parasol is a doctoral network at the intersection of electromagnetic compatibility emc materials engineering systemsafety engineering and sustainability management the project will include the safe and sustainablebydesign ssbd approach for vehicles the project researches electromagnetic em shielding solutions which are performancesdefining technologies in terms of em safety weight volume mechanical strength and the cost of a vehicle parasols science case is based on the integration and optimisation of every kpi in the ssbd approach this requires thinking in terms of a tradeoff across a new mix of disciplines to develop innovative solutions accordingly and to consider all the farreaching societal and technical consequences of the design choice up to now even most hightech industries are forced to manufacture several prototypes and perform tests because the actual performance of shielding in the final vehicles is unknown a characterisation strategy embedded in the ssbd approach is urgently needed parasol is the first training network dedicated to the inclusion of the ssbd approach in the design of electronic equipment it answers the recently highlighted pressing need for trained specialist in the field parasol involves 5 academic beneficiaries and 15 industrial associated partners across the complete lifecycle of design solutions from 8 countries a paneuropean approach in a multisectoral context is guaranteed universities an established startup smes and major industries while representing all types of vehicles land air marineparasol will train a new generation of scientific professionals who can transition between disciplines and take up leading positions in the field of electronics safety and sustainability while thinking differently in terms of design solutions these professionals can support europes ambition to play a major role in the safetycritical market for vehicles
safe and efficient storage of ammonia within ships

nh3craft aims at fully designing engineering developing and demonstrating a next generation sustainable commercially attractive and safe technology for highquantity onboard storage of nh3 as marine fuel two innovative modular and scalable steel and composite storage tank configurations for 1000 m3 liquid nh3 at 10 bar and the corresponding auxiliary systems will be installed on a 31000 deadweight tonnage dwt multipurpose vessel the exact vessel has been designated and provided by a participating major ship management company additionally five different types of vessels and corresponding fuelstorage tank concept adaptations will be studied and documented a sss bulk carrier a tanker and a container ocean going vessels a typical ropax ferry and a small inland waterways transportation passenger vesselan innovative digital platform will integrate all core simulations and models through digital interfaces and will develop an engineering system matrix and specifications for the fuel storage supply and piping monitoring and venting subsystemssafety and risk assessment for all vessels will lead to the development of safety guidelines and classification rules nh3craft will showcase the entire nh3 supply chain in order to increase confidence in its use and promote its uptake lca and technoeconomic evaluation will prove the sustainability and will support further exploitation and commercialization of the innovative solutionsthe vision is to pioneer the reduction of ghg emissions by at least 50 by 2050 compared to 2008 and the eventual elimination of total ghg emissions and air pollution from shipping sria for zewt goals remaining consistent with the paris agreement nh3craft aspires to help europe serve societal needs maintain global maritime leadership and support an innovationdriven industry with highly skilled jobs safe efficient and sustainable technological solutions with new international standards rules and regulations
resilient water governance under climate change within the wefe nexus

with increased water scarcity due to anthropocentric and natural causes the tradeoffs and synergies intrinsic to efficiently allocate water resources to various competing uses have become more polarized realizing the importance of an integrated approach in water governance the retouch nexus project introduces and promotes the waterenergyfoodecosystems wefe nexus as a multilevel and crosssectoral approach that advocates the eu water economy and in addition relies on ecological and social considerations the overall objective of retouch nexus is to design and foster integrated innovative and inclusive nexussmart water governance schemes and institutional settings to promote a secure water future in the eu resilient to climate change retouch nexus follows an evidencebased approach to propose assess and optimize a set of wefe nexus smart methods in six different case studies reflecting various crosssectoral multilevel and multistakeholder water governance contexts first the project will monitor water governance by providing a set of nexussmart socioeconomic and environmental indicators that reflect the crosssectoral and multilevel nature of water use second retouch nexus will design integrated and climateresilient water governance practices that ensure sustainable water systems it will also develop economic instruments and business models that support robust water management under crosssectoral competition third retouch nexus will foster more transparent inclusive and innovative engagement mechanisms that empower stakeholder and citizen participation in water governance finally retouch nexus aims to effectively increase the socioeconomic and environmental resilience of water governance in europe by upscaling and endorsing successful and sustainable nexusbased water governance interventions that will be designed and validated throughout the duration of the project
dataspace datashare 20

ds2 draws researchers and practitioners from diverse disciplines to secure that complex lifecycles of intersector data sharing aggregation and provenance take place in a humancentric and trusted way with common structures exportability and insight whilst protecting the sovereign rights of data owners and complying with european data regulations ds2 provides a modular software infrastructure to connect data sources data spacesdata silosdata lakes together for the purpose of crosssector data sharing once connected data consumers and data providers will be able to structure and execute efficient complex data lifecycles that respect the technical and governance related requirements of the participating data sources it will do this via an idt intersector dataspace toolkit which is deployed at each data sourcespace and network connected to any other idtenabled data source the idt toolkit is composed of a broker which manages the failsafe network operation with no central point of control plugged into this is a set of modules for the execution of complex data lifecycles eg filtering labelling both automated and catering for where humaninthe loop is required ds2 will pilot and evaluate its technology using 3 welldefined intersector use cases city scape green deal precision agriculture the ds2 solution enhances and accelerates the shift towards the data economy by addressing the challenges painpoints and requirements with respect to the execution of complex data lifecycle data consumers and data providers can now orchestrate manage and securely execute complex data lifecycles to realize crosssectorial data driven applications
nanoplatforms for neuroscience

neuronanotech will train eleven researchers to tackle one of the major challenges in europes ageing population neurological diseasesthe ability to monitor and modulate neural activity using interfaces has enabled a better understanding of brain function and has led to therapeutic solutions for some neurological disorders yet fundamental technological challenges such as ensuring proper brain tissue interfacing and reliable longterm recordingstimulation after implantation impede widespread clinical use new approaches to provide effective treatments are urgently needed neuronanotech will develop novel nanostructured flexible neural interfaces with highly improved tissue integration minimizing foreignbody reactions and tissue scarring and allowing stable stimulation treatments as main innovation we will develop minimally invasive ultrasensitive spintronic magnetic sensors able to record stably without interfering with stimulation signals and avoiding electrode degradation connecting both interfaces we will construct a lowinvasive closedloop neurostimulation system that integrates feedback signals from the neural activity and provides realtime stimulation of the target structures according to the patients needs to achieve these goals neuronanotech brings together experts in nanotechnology device engineering neuroscience and clinical neurology the individual research projects are highly interconnected ensuring interdisciplinary training researchers will benefit from training in advanced research and relevant complementary skills imparted by an international and intersectoral consortium of research institutes universities companies hospitals and social organisations from 9 different countries we will provide researchers a unique environment focused on innovation and collaboration with a view to commercial applications of the research results this framework will open researchers avenues in both academia and healthrelated industry
a multicentury history and future of fire occurrence in the mediterranean basin and its climatic and atmospheric drivers regime

wildfires in the mediterranean region pose a critical impact on human lives ecosystems and socioeconomic stability understanding the multidimensional nature of wildfires is crucial for assessing future ecosystem dynamics and fire management strategies the underlying coupled mechanisms of the interaction between fire climate components and atmospheric drivers that affect regional fire regime characteristics fire frequency seasonality severity extent etc are still poorly understood therefore there is an urgent need for interdisciplinary approaches to address climatic and atmospheric drivers of fire occurrence especially in fireprone areas with diverse regional climate conditions such as the pyrogenic forest ecosystems of the mediterranean basin the main goal of regime is to disentangle the complex relationship between fire occurrences and the climatic and atmospheric drivers in the mediterranean basin in the past and ultimately model the future probability of fire occurrence to do so a unique network in terms of spatiotemporal resolution of fire history of the basin will be created combining documentary records and treeringbased fire reconstructions wp1 the major modes of largescale climatic drivers atmospheric circulation patterns and teleconnections that modulate fire occurrence will be analysed to understand the complex link to fire occurrence wp2 lastly the potential future changes in fire occurrence over the 21st century will be evaluated to understand the driving factors and the potential consequences wp3 regimes multidisciplinary nature is novel and unique which involves a combination of welldeveloped dendrochronology atmospheric sciences and fire ecology comprehensively studying climatefire interactions climate teleconnections and modelling future fire occurrence based on climate scenarios will seek to inform effective fire management strategies policy development and climate adaptation measures across the basin