Dragon09/odtu_chatbot huggingface dataset:
electrically triggered zwitterionic polymers for water harvesting solutions

more than twothirds of the global population will experience severe water scarcity by 2030 water harvesting wh and managing strategies need to be developed urgently in europe to face this challenge since climate change makes rain and drought unpredictable water harvesting materials need to collect and release water with deterministic stimuli as electricity the applicant experienced researcher er during her phd and first postdoc studied the interaction between water and conductingsemiconducting polymers she worked on a conducting polymer with glycolated side chains able to undergo volumetric expansion driven by ions and water intake she believes that such materials are promising for wh as the collection and release is driven by an electrical stimulus to increase the water stabilization and retention she plans to synthetize a new class of polymers based on an electricalresponsive backbone and zwitterionic waterstabilizing side chains to this end the er will be trained on design synthesis and characterization of polymers at the host institution the basque centre for macromolecular design and engineering polymat by prof david mecerreyes a leading expert in design and synthesis of innovative polymers she will then fabricate a prototype that will be tested in a greenhouse on living plants during the secondment at the linköping university liu with the electronic plants group led by prof eleni stavrinidou an emerging expert on interfacing polymers and plants finally the er will spend a placement at the end of the fellowship at the polykey a startup focused on sustainably scaling up laboratory polymerization processes dr andere basterretxea the ceo of polykey will supervise the er training her on scale up procedures esprinkle will contribute to the scientific and personal growth of the er who at the end of this fellowship will be a highly specialized competitive profile as independent research leader or as manager in industry
shaping functional ecosystems of the future

accelerating climate change is moving ecosystems rapidly beyond the bounds of historical variability many of the traditional conservation approaches trying to maintain a status quo are no longer effective rather than resisting change we need to guide transforming ecosystems towards preferred ecological outcomes assisted migration the active translocation of species to mimic range expansion under climate change is a widely proposed adaptive management strategy but it is also controversial as it disrupts longheld views on biological conservation focusing on risks and ignoring benefits has hampered scientific research on assisted migration and halted necessary conservation innovation yet the costs of inaction are too high and time is running out in futurenature i will approach the assisted migration of plant species from an innovative functional perspective shifting the focus from minimising the impact of translocated species to maximising their contribution to the functioning of novel communities i will advance our understanding of how assisted migration can safeguard functioning ecosystems by combining the wealth of large observational databases stateoftheart joint species distribution models and a cuttingedge climate change experiment specifically i will 1 study the contribution of noninvasive alien species to ecosystem functioning 2 incorporate species interactions and traits into species distribution modelling to simulate novel grassland communities and 3 experimentally test the functionality of the best performing communities under future climate scenarios with the knowledge gained we will be able to shape ecosystems that will not only survive but thrive under climate change futurenature will provide a greenprint to study assisted migration across species groups and ecosystems and ideally enable a paradigm shift in conservation thinking by lifting the psychological barriers preventing changes in natural ecosystems
improving the effectiveness and safety of epigenetic editing in brain regeneration

the central nervous system has a limited capacity for selfrepair therefore technologies to replace lost neurons after an injury including stroke or neurodegenerative diseases are of great need the project regenerar aims to develop a nonviral delivery formulation up to trl4 for the delivery of an epigenetic reprogramming formulation to reprogram glial cells into neurons the in vitro safety and targeting of the formulation will be tested against glial cells and organotypic cortical slice cultures several routes of administrations will be tested to enhance the accumulation of the formulation in the brain in addition the in vivo safety elimination targeting and epigenetic reprogramming will be evaluated in addition toxicological studies will be performed in glp conditions to evaluate both in vivo systemic and local brain effects of the formulation the development of the nonviral formulation will take in account the contributes of key stakeholders in the area of gene editing health institutions patient associations among others a roadmap will be developed for upscaling innovation to higher trls upon the end of the action
the ultrastable state of metallic glasses and its role in the structural pathway of ageing

what are the structural characteristics of ultrastable metallic glassesthe recently discovered ultrastable state of metallic glasses mgs exhibits a variety of thermodynamic stability levels in combination with an enhanced kinetic stability as a hypothesis observed levels of excess enthalpy originate from faster relaxation contributions that are locally embedded in an otherwise stable structure such features remind strongly of novel mgstates of structurally heterogeneous glasses that were recently reported by experiments on conventional mgs and molecular dynamics simulationsthe aim of the pathage project is to test the hypothesis in terms of the ultrastable mgs relation to these novel structural states this builds on quantifying the evolution of the ultrastable state in response to thermal stimulus by tracing the structural transformation towards the supercooled liquid or eventual crystallization three possible mechanistic routes will be considered first a frontinitiated process as observed for ultrastable molecular glasses second a homogeneous structural evolution triggered by fast relaxation contributions third a transformation involving an underlying phase transition of a heterogeneous glass statein order to distinguish between the proposed transformation scenarios the following novel experimental approaches will be used in addition to traditional methods the socalled singleparameterageing formalism known from the field of molecular glasses which will allow for predicting and testing the homogeneous ageing scenario surface sensitive methods that probe nanoscale heterogeneities revealing the formation of structurally heterogeneous glassy states spatially resolved electron diffraction combined with atomistic simulations to identify preferred local structural motifsin concert these approaches will significantly enhance the understanding of the unique ultrastable mgstate thereby unlocking potential for novel applications of mgs
evolution and molecular mechanisms of adaptive organ allometry in atlantic salmon salmo salar

species radiations can be driven by changes in body proportions allometric changes that is natural selection acting on size and not in shape discovering the genetic and developmental basis of allometry has both fundamental importance for understanding the emergence of biological diversity as well as in practical terms such as in understanding cancers only a few allometry mechanisms are known to explain adaptive differences in organ size within a vertebrate species the salmoscales project will fill this knowledge gap by discovering the molecular developmental and evolutionary mechanisms that give rise to allometry of reproductive organs in atlantic salmon salmo salar salmon show a fascinating adaptation of organ allometry associated with a tradeoff in life history strategies dwarf landlocked ecotypes prioritize egg size over egg number and in consequence have ovaries that are 50 smaller compared to their seamigrating congeners the decreased ovary size in dwarf salmon provides a unique model to study how allometry emerges within a single species and interplays with life history strategy salmon reproductive development is governed by transcriptional regulators that include the genes vgll3 and six6 these genes are top candidates for mediating ovary allometry as my preliminary results suggest that vgll3 interacts with hippo signaling pathway mediating organ size as well as transcription factors controlling for germ cell development in salmon gonads i will dissect the genotypephenotypefitness map of ovary allometry from the molecular to the species level with an integrative approach combining cellular genomics gene editing and a powerful quantitative genetics framework the results will have applied significance in aquaculture to inform precision breeding for egg brood and maturation characteristics as well as in the medical field where revealing the mechanisms that coordinate ovary growth and size are important to understand ovarian cancers
myopia control in the real world treatments target timing and terminus

background myopia or nearsightedness is increasing dramatically all over the world mostly due to higher levels of education and changing lifestyles of young generations the expectation is that half of the worlds citizens will be myopic by 2050 myopiarelated complications later in life are a serious threat to vision and will increase the rates of blindness prevention strategies and pharmacological and optical treatments to delay progression of myopia in childhood are emerging but most eye care professionals still do not control myopia due to inadequate information and unpredictable outcomes aim to radically improve patient management in myopia by providing an agile aibased clinical decision support system stooled on a solid scientific basis of integrated multidisciplinary data approach 1 to construct populationbased reference centiles for eye growth and progression of myopia for screening and surveillance of myopia in young generations in europe2 to capture highquality longterm prospective data from the real world on myopia control and specifically gain evidence on timing effectiveness side effects and acceptability of current treatment modalities in daily practice3 to investigate patient profiles for poor response and adherence to myopia control4 to predict the final outcome of myopia based on a plethora of potential predictors using advanced machine learning techniques5 to develop the controlmyopia platform with a usercentred and highly interactive design which provides an accurate prediction of myopia outcomes with and without myopia control and which recommends the right prevention and treatment for the right patient at the right timeimpactcontrolmyopias outcomes will have widespread impact on clinical care patient participation public health design of clinical trials research innovation and policy changes
improve interconnected innovation ecosystems supporting actions for citizen awareness and twin transition in the entire cosmetic value chain

actt4cosmetics aims at fostering the creation of a more efficient open inclusive and interconnected innovation ecosystem in the field of cosmetics across europe by drawing on the strengths of existing ecosystems and by pulling in new less wellrepresented stakeholders and less advanced innovation territories by implementing joint activities between ri actors public authorities and the private sector towards innovation deployment actt4cosmetics aims to integrate the entire value chain of the cosmetic industry to implement structural changes such as digital and ecological transitions but also innovation as a lever for sustainable growth to respond to the main local and eu challenges in the field of cosmetics for the benefit of the society to improve the digital and sustainability maturity and to find innovative sustainable solutions the consortium will use actt4cosmetics to inform the stakeholders train the entire ecosystem through capacity building actions boost sectorial and cross sectorial collaborations and share funding opportunitiesactt4cosmetics has 3 ambitious general objectives in line with the horizoneie2022connect02 call expectations i innovation deployment through digital transition in the cosmetic sector ii reinforcing green transition in the cosmetic sector in order to fight climate change iii create consumercitizen awareness of implication in and sensibilization on cosmetic industryactt4cosmetics gathers 8 partners and 2 associated partners from 6 countries the partners are very complementary as they have both common assets and separate key competences an implementation plan is presented in the form of 7 work packages synergy in communication and dissemination by the partners and stakeholders will permit to maximize the actt4cosmetics project impact solutions to overcome the fundamental barriers by creating an open inclusive efficient cosmetic ecosystem to go towards digital green and societal transition all over europe
climatejusticeready

cities in the global north are increasingly adopting naturecentered and other green infrastructure interventions to respond to climate risks and impacts and enhance their adaptation and resilience capacity yet plans for such green infrastructure gi and other urban greening interventions tend to underestimate risks of displacement for lowerincome and minority residents what myself and others have previously called green climate gentrification despite increasing recognition of this process and concerns for the displaced few municipal green interventions are coupled with social provisions such as social housing residentdriven economic development schemes to protect residents from displacement yet predicting and preventing green gentrification is the only way to build a green resilience agenda that upholds the stated social and environmental goals of such plans and avoid green paradoxes born out of urban renaturing projects and which municipalities have expressed commitment to avoid in this poc i propose to further analyze the social equity impacts of climate adaptation and green resilience efforts and build on my greenlulus erc in order to a create a replicable interactive community and policydriven predictor index tool and analysis for green gentrification in the context of planned green climatecentered infrastructure and b test the early development of an actionable pilot municipal policy and planning instrument such as a climateadaptation focused community land trust a municipal green bond program for equitable climate resilience a communitybased stewardship fund or green minorityowned green business seed grants among others to prevent green climate gentrification these tasks will be decided and built in partnership with municipal governments and community groups based on pilot cities included in my finishing erc project barcelona and boston so that this poc can support them in their work for more just green cities
quantum applications with rydberg atom arrays

rydberg atoms arrays have emerged as a promising platform for assembling quantum matter in a bottomup approach this platform combines deterministically prepared reconfigurable arrays of individually trapped cold atoms with strong coherent interactions enabled by excitation to atomic rydberg states and in situ state readout it enables a scalable realization of quantum spin models with system sizes beyond what can be simulated on classical computers the main goal of this project is to harness manybody properties of rydberg atoms for applications in nextgeneration quantum technology the first goal is to explore the possibility to harness a novel robust dynamical quantum manybody phenomenon as a tool to generate useful entangled states in systems with limited control specifically we will study the entanglement properties of quantum manybody scars a natural phenomenon first discovered in rydberg atoms arrays regarding their utility for measurementbased quantum computation quantum error correction and quantum metrology our second goal is to study and develop novel approaches for implementing information processing protocols with rydberg atom arrays based on an intimate connection to maximum independent set problems this includes the exploration of analog quantum annealing algorithms the development of noiseresilient gate sets for circuitbased approaches and preparation and manipulation of topologically protected qubits the third objective is to develop novel tools to characterize quantum manybody states of rydberg atom arrays and access fundamental properties such as entanglement measures
spactory revolutionising pharmaceutical development and manufacturing through microgravity

over 2000 rd experiments have been done in space until now space nearzero gravity yields biochemical crystals orders of magnitude more defined pure uniform and precise than in terrestial environments the lowgravity accelerates the development and preclinical testing of complex molecules eg proteins and unleashes the potential of innovative highvalue mabs therapies saving patients lives and improving their qolto make it real after 11 space missions spacepharma is committed to bringing the first mabs factory to space moti the main spactory building block brings accessible scalable and affordable microgravity manufacturing controlled from earth and able to fly in any satellite compatible with any launcher for our customers the pharma industry it means shorter time to space faster market access and affordable drug development for spacepharma it is a paradigm shift from drug rd to manufacturing for eu it means leading the spatial race in drug development
stem cell riboregulation a new layer to control selfrenewal differentiation and metabolism

although multiple regulatory layers have been reported to control stem cell differentiation including epigenetics cell signaling and metabolism we still lack sufficient knowledge on how differentiation processes are connected and coordinated the hentze laboratory recently discovered that rna modulates riboregulates the activity of the glycolytic enzyme enolase 1 eno1 and that this interaction is essential for in vitro murine embryonic stem cell differentiation additionally unpublished data from the laboratory show that the glycolytic enzyme pyruvate kinase pkm is also riboregulated however the role of riboregulation during primary stem cell differentiation remains elusive previously rnabound proteomes have either been identified in cultured cells or ex vivo in whole organs i aim to investigate enzymerna interactions in primary stem cells and differentiated progeny using the hematopoietic system as a model first i will analyze the rnabinding activity of previously in cellulo profiled enzymes eno1 and pkm in vivo and ex vivo during hematopoietic stem cell hsc differentiation by rnaproximity ligation assays profiling of stem cell activity and transcriptome analysis aim 1 secondly i will analyze identify and comparatively quantify global rnaprotein interactions in hscs progenitors and mature blood cells by developing a method to profile in vivo rnaprotein interactions aim 2 in an interdisciplinary approach i will pair fluorescenceactivated cell sorting with stateoftheart rnaprotein crosslinking approaches and ultralow input proteomics analysis the generated data will help for the first time to understand at the analytical and functional level whether and to what degree riboregulation of enzymes represents a regulatory paradigm operational in mammalian cells with a focus on hematopoietic stem cell differentiation
preparing the ground for autonomous multimodal supply chains

autosup will drive the industrial transition to seamless multimodal automatic freight transport and enhance the operation of hubs as nodes in a physical internet logistics network a multidisciplinary team of 17 partners including four organisations engaging in the activities their ecosystems of transport and logistics stakeholders willdefine automation requirements for seamless multimodal automatic freight transportempower stakeholders with an open readytouse datadriven decision support system to help them implement and deploy automated processes and solutions and make strategic decisions about future investments the systems will support undertaking feasibility studies via simulation to assess the efficiencies and impact of new solutions whilst considering sustainability financial and social impactssupport the transition path to automation in two living hubs antwerp and trieste ports focusing on the link of the two large transport nodes with road corridors rail inland waterways and airports covering 6 diverse use casesdesign new operational governance and organisational change management models for autonomous logistics that incentivise crossmode collaboration and reduce investment costsvalidate operational and cost efficiencies of solutions via feasibility analysis impact assessment and the engagement of representative stakeholdersestablish a strategic and cohesive alliance and thematic working group for the alignment of multimodal automation adoption roadmaps across rail road aviation waterborne and alternative innovative modes of transport and contribute to lowering automation adoption barriers through comprehensive transition guidelines capacitybuilding sessions and policy recommendationsautosup integrates social innovation practices in research to foster automation adoption and enhance safety accounting for the workforce dynamics and skills needed for the transition to autonomous operations
artificial induction of tertiary lymphoid structures tls in tumors using intratumoral mrnas to evaluate its synergy with immune checkpoint inhibitors

tertiary lymphoid structures tls are ectopically generated lymphoid structures with some level of cellular organisation similar to the secondary lymphoid organs characterised by having a bcell zone adjacent to a tcell zone the presence of tumor immune infiltrates especially in the form of tls has been linked to a better cancer prognosis in different types of tumor and improved response to immune checkpoint inhibitors icb however interestingly not all the patients develop tls and the cellular composition and organisation within the structures can vary specifically the role of b cells in the tumor microenvironment is controversial while some studies have reported a protumoral effect possibly through differentiation of regulatory b cells metadata shows a strong association between the presence of a transcriptional b cell profile on the tumors and the improved patient outcome moreover the presence of b cells in the tissue microenvironment is also positively associated with an improved response to icb however even though these strong statistical associations and the relevance of tls in the cancer prognosis still little is known about the mechanisms underlying their function and the specific role of b cells in the antitumoral response elicited in this proposal we will study novel therapies for artificial tls induction by using intratumoral injection of mrnas encoding for specific cytokines we will deeply characterise the synergy between immunotherapy treatments and tls in the tumor development by using the stateofthe art spatial transcriptomics and immunophenotyping finally we will decipher the function of tumorspecific b cells on the tumor microenvironment and the relevance of tumorspecific secreted antibodies in the overall antitumoral response ultimately the knowledge generated with this proposal will provide relevant information to guide future immunotherapy treatments