Dragon09/odtu_chatbot huggingface dataset:
bridging knowledge communication and action for food safety in a changing climate

ambrosia aims to transform the european approach to food safety in view of the impacts of climate change it will enable for the first time a holistic systemic approach to food safety risk assessment across the supply chain in view of climate change models with the use of digital technologies including ai bridging the knowledge of agrifood and climate modelling and forecasting scientists and experts in food predictive microbiology and risk assessment ambrosia will make possible the modelling of climate change risks individual and cumulative and their impact on food safety from farm to fork in 4 major biogeographical regions within europe atlantic boreal continental and mediterranean as well as the prediction of likely novel sources of risk and hazards across key food groups consumed by eu citizens first the project will develop a tailor made holistic risk assessment methodological framework for the study of climate change impact on food safety the use of spatiotemporal climate model projections will be integrated with models of food safety hazards to enable the development of detailed predictive models then a digital platform will be developed and deployed for the integration of climate model projections with food safety data for the purposes of prediction and monitoring of food safety risks and hazards emanating from climate change events or processes as well as for the communication of mitigationadaptation measures extensive use will be made of a variety of data sources to enable the use of ai techniques deep learning for predictive modelling to be fully used in the food safety domain the project will focus on fusarium mycotoxins a recognised hazard from grains wheat oat barley corn and derived products and enteric pathogens salmonella e coli in fresh produce vegetables and salads using a multiactor approach ambrosia will raise awareness and provide strategic advice on mitigation and adaptation strategies
ctpdependent molecular switches an emerging new principle in cellular regulation

nucleotidedependent molecular switches play key roles in the regulation of cellular processes such as translation protein folding and transport cytoskeletal dynamics and cell differentiation until recently their function was thought to rely exclusively on the purine nucleotides gtp or atp as cofactors this paradigm changed in 2019 when my group identified a fundamentally new class of regulatory switches now called cswitches that depend on the pyrimidine nucleotide ctpthe few cswitches studied to date have important functions in bacterial growth and pathogenicity database searches predict that cswitches are highly diverse and widespread in nature however the physiological roles and modes of action of these proteins are still largely enigmatic the overarching goal of c switch is to provide comprehensive insight into the biology of cswitches and clarify the ways in which this newly identified regulatory principle can control protein activity and cellular functions for this purpose we will employ both bioinformatic and experimental methods to systematically identify new types of cswitch proteins and perform detailed mechanistic studies of prototypic representatives using stateoftheart in vitro and in vivo approaches cswitch will thus break new ground in the understanding of cellular regulation and pave the way to a global understanding of cswitches as versatile regulators in biology importantly proteins containing a canonical cswitch domain are absent from humans and other mammalian systems cswitch will therefore also explore the pharmacological potential of cswitches as new targets for antibacterial and antivirulence therapies thereby possibly opening new avenues for translational applications and supporting the current global effort to combat bacterial antibiotic resistance
research infrastructure technology infrastructure for impact

research infrastructures ris and technology infrastructures tis are both essential and complementary elements for functional and efficient ri ecosystems in europe they play a crucial role in strengthening european ri capacities from exploratory research to the development validation and integration of innovative knowledgebased solutions into new products processes and services the ritifi consortium composed of ri and ti stakeholders from 19 european countries aims to improve the integration and structure of the european ri landscape it will do so by developing a functional framework for the integration of ri and ti services tailored to the needs of endusers by providing guidelines and methods to improve the visibility and access conditions of ri and ti to endusers by developing an agile and tifriendly governance model at european level provide a comprehensive and multilevel analysis of the ri and ti policy landscape and propose an action plan to ensure alignment and synergies of access policies develop a process for prioritisation and synergies of investment plans for ri and ti sustainability raise awareness and stimulate the inclusive engagement of managers users and policy makers in the development of an integrated ri and ti landscape the project will follow a 4phase methodology based on the validation of ri and ti concepts to ensure a common understanding development of a strategic analysis of the ti landscape and a strategic analysis of the integrated ri and ti landscape in 5 selected areas based on the information gathered and extended beyond the selected areas recommendations to policy makers and the riti community will be drafted in parallel the project will engage with the community from the beginning creating awareness promoting knowledge sharing validating results and encouraging adoption thus an ri ecosystem with interconnected and sustainable ri and ti will accelerate the digital and green transition in europe
next generation xrayh micro and nano scintillating detectors

modern radiation therapy treatment is driven by the everlasting demand for suitable detectors that can perform under different radiation beams photon proton electron ion etc at small fields the industrially developed dosimeterdetectors are still limited by the significant size requirement volume averaging effect lack of sensitivity correction factors and low signaltonoise ratio etc thus quality treatment is still hampered and continues to risk the patients in addition scintillatorbased xray cameras are still suffered from low compactness modest response time and crosstalk which shows strong limitations in the existing technology in this context this research work is devoted to the design and fabrication of a novel extremely compact realtime dynamic and highly sensitive xrayh micronano scintillating detector xmind the developed microdetector will be tested for highenergy photon and particle beam characterizations along with simulation techniques a multidosimeter system exploited from a bundle of single detectors will be realized and tested targeting the next generation xray cameras subsequently a nanometric scintillating detector will be demonstrated in surface physics application in synchrotron targeting highresolution local 2d chemical mapping of a material by employing a novel dualprobe technique thus the medical outcomes of this research will explore miniaturized dosimetry exact dose verification in the small field that initiates earlystage tumor treatments and the first step of new generation xray cameras with improved performances the physics outcomes are expected in the direct surface imaging of xray freestanding waves xsw the new fundamental knowledge developed in this project could be applied to other multiple domains from the project i aim to improve my expertise by trainingthroughresearch with leading experts worldwide and bring this knowledge back to europe to share and integrate me
lighting the way towards in situ osteochondral regeneration through microextrusion and filamented light bioprinting

traumatic injuries to the osteochondral tissues of diarthrodial joints like the knee result in pain functional impairment and increased risk of developing posttraumatic osteoarthritis ptoa and its comorbidities current treatments based on cellfree grafts or cellbased therapies are expensive and often with limited availability ultimately leading to total arthroplasty to relieve the pain and restore function however the risk of revision of these implants is unacceptably high in young active patients predicting a looming epidemic of revision surgeries as these implants start to fail luminate proposes a personalized onestage regenerative approach to target large osteochondral lesions thus preventing ptoa and avoiding costly and invasive arthroplasty surgeries luminate will develop a next level in situ bioprinting unit called endoflight which combines three toolheads ie microextrusion filamented light jetting to print photoresins laden with patientderived cells directly at the site of injury endoflight uses filamented light to bioprint highly architected scaffolds with excellent cell guidance properties in seconds together with microextrusion and jetting toolheads in an arthroscopic setup we can deposit multiple biomaterials biomolecules and cell types together with lightassisted crosslinking of complex structures directly in vivo in a minimally invasive manner the whole procedure will be extensively validated in a humanrelevant in vivo large animal model paving the way for clinical translation after the end of the project the exploitation of the results will be ensured through market analysis the foundation of a spinoff that will commercialize the project results and analysis of regulatory aspects of all components of the bioprinting suite overall luminate will ensure widespread health benefits to the patients suffering from these lesions and will pave the way for enormous socioeconomic advantages for our aging society
integrated emerging approaches for joint protection and restoration of natural lakes in the spirit of european life heritage support procleanlakes

procleanlakes targets to combat the combined impact of various disruptive factors that generate continuous pressure on the lakes ecosystem status and facilitate the accumulation of emerging nonregulated chemical contaminants and nutrient enrichment the project will design and demonstrate the feasibility of integrated naturebased emerging approaches for joint protection and restoration of european natural lakes enl and their biodiversity considering scenarios which imply the presence of various pressures that affect the aquatic ecosystems status the holistic transdisciplinary approaches that are to be used in the project based on the synergic effect of the economicenvironmentsocial nexus targets to support the improvement of enl ecological and chemical status in association with major eu instruments sustainable development goals and policies related to freshwater ecosystems the project engages multiple sites affected by the presence of various pressures and stressors that will be the subjects for the demonstration of integrated protection and restoration solutions efficiency a replication roadmap powered by the necessity of assuring upscaling and universality of the optimal integrated solutions is will be developed to prove the replicability an is support platform which merges a business accelerator with an adaptive artificial intelligence ai solution for empowering citizen science related to lakes protection and restoration will assure the collaboration between the municipalities and citizens and will offer capacitybuilding and encourage codevelopment and codesign towards natural lakes protection and restoration tools such as mobile decision support platforms serious games for digital readiness elearning and augmentedbased modules for reinforcelearning and multiple ai machine learning analytical frameworks will be developed to assure the synergic approach toward the maximization of integrated solutions impact and replicability
intelligent lung support for mechanically ventilated patients in the intensive care unit

invasive mechanical ventilation mv is one of the most important and lifesaving therapies in the intensive care unit icu in most severe cases when mv alone is insufficient extracorporeal lung support els is initiated however mv is recognised as potentially harmful because inappropriate mv settings in icu patients are associated with organ damage contributing to disease burden studies revealed that mv is often not properly provided despite clear evidence and guidelines furthermore treatment decisions by the healthcare providers especially regarding mv and els often remain incomprehensible to the patients and their relatives since flow of information from caregivers to patients is challenged by a number of factors including limited time and resources communication problems as well as patients capacity to comprehend and memorise information the project proposed herein aims at clinically validating and extending our intellilung artificial intelligence decision support system aidss designed to optimise mv and els settings to improve the care of icu patients alongside caregiverpatient communication thereby best practice evidencebased mv and els within safer therapy corridors for longer periods faster weaning from mv and improved survival could be achieved even in nonexperienced hands additionally this project will improve the information flow from caregivers to patients and relatives in the icu setting therefore we will develop a digital solution that allows automatic generation of an extensive plainlanguage information package for patients and their relatives communicating highly individualised information on diseases and knowledgebased diseasemanagement strategies thus facilitating highquality current and subsequent care through health literacy empowerment and patientcentredness we will perform a retrospective and prospective multicentre study to validate our intellilung aidss and the patient information software
bridging research institutions to catalyze generative ai adoption by the health sector in the widening countries

in a bid to harness cuttingedge ai advancements slovenia and austria ai research frontrunners united with two widening countries north macedonia and serbia to propose a transformative mission to bridge the knowledge gap and to propagate generative ai expertise with the goal to meld ai into pragmatic medical contexts together they are laying a foundation for a crossborder collaboration methodology that through training missions workshops seminars and collaborative deep dive research would enrich minds and redefine medical practices the collective effort wisdom and adaptability as a guiding principle will dive into the core of the large language models to explore the capability of transforming complex medical knowledge into valuable medical diagnoses and treatment recommendations through simulated realworld medical challenges the team will resonate in the practicality of generative ai and the specific requirements that such aibased software would require to be implemented practically in the hospitals through this project the partners from the widening countries will master coordination skills while the research on generative ai will alter the medical landscapes
integrated climate action

the iclimateaction project addresses the need of increased coordination and synergies among the global climate observing system gcos the group on earth observations geo and the world meteorological organization wmo to improve the international alignment across organisations regarding creation management and utilization of climate data all three organizations have key coordination functions along the value chain of climate data including production curation and exploitation and that support evidencebased decisionmaking to manage risks and adapt to a changing climate the iclimateaction will support gcos geo wmo in their common endeavor to strengthen the global system for standardized open accessible usable and interoperable global observation systems for essential climate variables ecvs and aiming at a shared and coordinated strategy towards the development of a more coherent sustainable and comprehensive global observing system for climate the iclimateaction strategy serves the implementation of eu actions supporting eo programs including the copernicus services esaclimate change initiative eumetsat satellite application facilities and aiming at enhanced climate data uptake to fulfill the european green deal guided by its overarching objective to advance the current observing system and its ability to monitor and predict the evolution of the earths climate the project will develop its action plan around 4 specific objectives implemented through 7 work packages and 2 useful demonstrators allowing to cluster existing activities around urban and ecosystems resilience serving as benchmarks for the coordination and providing focus on two climate change adaptation and mitigation areas of relevance for science and policy making goals the iclimateaction project will foster eo data exploitation and deliver a set of recommendations for a sustainable interorganization coordination to maximize the value and impact of the eo data chain
training doctoral researchers in advanced strategies towards energyneutral wastewater treatment

neuten pioneers a comprehensive approach to tackle the two most challenging environmental health and societal issues including water pollution with key priority pollutants kpps and the need for clean and renewable sources of energy current chemical treatment technologies developed for the degradation kpps are mostly energyintensive and costly established biological wastewater treatment systems eg anaerobic digestion only remove certain kpps to a limited extent neuten will innovate in advanced and sustainable catalytic systems for the generation of energy carriers or the conversion of kpps from wastewater to energydense hydrochar wp1 manipulation of the microbial consortia and design of highly novel support structures will also enhance renewable energy carrier generation and superior kpp removal efficiencies from anaerobic digestion systems wp2 lastly the integration of both chemical and biological treatment methods will be investigated with the ultimate goal of achieving selfsustained wastewater treatment systems wp3 implementation of artificial intelligence tools and market behaviour analysis allows for the development of business models that are not only environmentally sound but also economically viable wp4 the project aims to train 15 highly skilled doctoral candidates providing them with a unique interdisciplinary and intersectoral research training program by a broad consortium encompassing 18 intersectoral partners 6 academic 12 nonacademic in 10 countries the highly relevant field combined with an advanced training program that encompasses transversal skills and training through research will ensure that highly trained professionals will enter the job market further strengthening the competitiveness of the eu in this domain neutens holistic approach promises to set a new standard in water treatment technologies with longterm impacts on environmental protection public health and economic sustainability
tracking hydrates in refined subneptunes to tackle their emergence and evolution

thirstee is a groundbreaking project focusing on subneptunes a class of planets with masses and radii between those of earth and neptune these planets are the most common in the galaxy especially around sunlike stars but the most basic questions about their origin and nature remain unanswered are subneptunes gas dwarfs earthlike cores surrounded by large hydrogenrich envelopes formed near their observed closein locations or water worlds planets formed beyond the snow line composed of a 11 mixture of ice and rock if the latter exist what are their demographic and individual properties and how do they depend on stellar host type do any of them harbour liquid water oceans below their atmospheresthe gas dwarf hypothesis has the most traction in the field but recent evidence suggests the existence of water worlds the observations however can be explained by both scenarios due to the modelling degeneracies that surround these planets thirstee aims to solve this debate using a multitechnique approach combining transit radial velocity and atmospheric characterization data with a novel statistical framework that accounts for observational biases this dataset constitutes a valuable addition to the community enlarging the known sample into unexplored regions of the parameter space and enabling a direct comparison with synthetic planet populations thirstee is designed to mitigate all the shortcomings that have prevented previous studies from reaching conclusive results about this enigmatic population for the first time such an ambitious program can be pursued thanks to the simultaneous operation of stateoftheart observational facilities the project seeks to answer key questions about subneptune formation and evolution their atmospheres and their demographic properties thanks to its unique approach thirstee will revolutionize our understanding of subneptunes and their potential significance in the search for life beyond earth
beyond influence the connected histories of ethiopic and syriac christianity

the innovative beinf project interrogates the connected histories of ethiopic and syriac christianity in their various complexities and nuances it accomplishes this task through a series of five discrete but complementary case studies addressing 1 aramaic loanwords in ethiopic 2 the socalled nagran episode in which the sixthcentury aksumite ruler kaleb intervened on behalf of syriac christians who were being persecuted in the arabian peninsula 3 the ethiopic abba grima gospels including especially their illumination programs 4 the hagiography of the nine saints who are alleged to have brought about a second christianisation of ethiopia in the late fifth and early sixth centuries 5 the ethiopic reception of syriac literature beinfs innovation is multifaceted it adopts a multidisciplinary approach that brings together methods that are traditionally categorized as distinct and disconnected including especially art history linguistics manuscript studies philology textual studies and history in addition it rejects area studies and unites fields that have traditionally been isolated and siloed off in problematic ways finally it proposes to move beyond influence as an analytical category for analysing connections contacts exchanges and the actors and cultural brokers responsible for them and instead adopts a methodological and theoretical stance inspired by connected history especially in the sense of histoire croise with these innovations beinf is positioned to make significant longlasting contributions to the field of ethiopic studies both in content and in concept while also serving as a paradigmshifting model for other projects in the humanities addressing areas of inquiry that have traditionally been dominated by illframed questions of influence and that are primed to move beyond influence to explore connected histories with all their nuance complexity and texture through a multidisciplinary approach