Dragon09/odtu_chatbot huggingface dataset:
sunperform synthetic biology united with nanotechnology a biohybrid approach to improve lightharvesting and co2 fixation for high performance sustainable solar fuel production

the advancement of direct solar fuel technologies is key to provide a sustainable secure energy supply for the eu and other global regions and for the challengingtoelectrify aviation and maritime sectors stateoftheart technologies for solar fuel production including natural photosynthesis suffer from low solartofuel conversion efficiency low production rates and prohibitively high costs within the framework of sunperform we will address these critical limitations through an innovative biohybrid approach based on innovations in nanotechnology and synthetic biology sunperform aims to 1 to develop artificial nanocrystal lightharvesting systems to efficiently harvest a larger part of the solar light spectrum 2 to generate advanced microalgal solar cell factories by introducing synthetic pathways for a more efficient rapid conversion of light energy and co2 into lipid fuel precursors microalgal lipids are promising hydrocarbons for fuels being already approved production pathways for sustainable aviation fuel however current lipid production is still too inefficient and slow hindering the costeffective generation of renewable fuels through the implementation and integration of groundbreaking innovations at a pilot scale sunperform aims to achieve a remarkable fourfold increase in the existing solartofuel efficiency this will be demonstrated across two case studies reflecting the different solar irradiances received in europe and africa in addition to technical advancements sunperform will comprehensively evaluate the sustainability technoeconomic and social aspects of this novel route to guide its development as a truly sustainable secure and affordable production platform diverse stakeholders including industry and several partners in africa will be involved in sunperform to support the global development and the european leadership and export position for solar fuel technology
largescale electrosynthesis of borylated azines

the nobel prizewinning suzukimiyaura crosscoupling involves the palladiumcatalysedcoupling of a borylated molecule with an aryl halide and is the 2nd most used process by thepharmaceutical sectorazines are smallmolecules integral to discover and manufacture pharmaceuticals andagrochemicals using azines in suzukimiyaura crosscoupling reactions represents the idealsolution to introduce these important motifs in discovery molecules but here is where theproblems come1 there is currently very limited way of borylating azines2 borylated azines especially the ones containing a boron vicinal to the natom arehighly unstablewe urgently need chemical methods delivering borylated azines in a fast and costeffectivemanner and that can then be employed in suzukimiyaura crosscoupling reactionsas part of our erc2018stg nebular focused on the development of novel photochemicalstrategies in radical chemistry we recently identified a strategy that generates boryl radicalsand provides far greater capability over any other method to both prepare and utilizeborylated azines in modular fragment synthesisbelectro aims to make the synthesis of our borylated azines workable on large scale andthus attractive to pharma and agro industriesthis program provides a unique opportunity for the commercialization of our borylatedmaterials and their utilization by endusers thus providing innovative chemistry solutions andlonglasting impact to pharmaceutical and agrochemical industry and eventually our society
spatiotemporal coordination of microtubuleorganizing centers in two evolutionary distant eukaryotes

microtubuleorganizing centers mtocs are key eukaryotic structures for microtubule nucleation and organization many mtocs contain centrioles organelles with two critical functions i in mitosis they localize to the pole of the mitotic spindle aiding its organization ii after cell division centrioles are repurposed as basal bodies at the plasma membrane where they are essential for ciliaflagella formation defects in centriolebasal body cbb repurposing can have devastating consequences and lead eg to infertility in human sperm cbb functions correlate with subcellular localization but is the spatiotemporal control required for this organelle to fulfill two distinct functions how did the ancestral cbb evolve these functions and why are different mtocs not present simultaneously in a cell to tackle these questions i will first analyze and compare cbb repurposing strategies during the cell cycle of the green alga chlamydomonas rheinhardtii with those in the complex life cycle of the acellular slime mold physarum polycephalum two evolutionary distant eukaryotes to do so i will develop and apply a correlative microscopy workflow in which timelapse imaging of cells is followed by cryofixation and expansion microscopy cryoexm combined with stimulated emission depletion sted using transient overexpression and laser ablation i will interfere with spatial and temporal control of cbb repurposing to elucidate the role of subcellular location of this bifunctional organelle further i will study how cells cope with several different mtocs at a time likely competing for tubulin this project will provide a novel highend correlative livecell and superresolution imaging pipeline which can be easily adapted for various species and cellular structures understanding the different strategies of cbb repurposing that evolved will have broad implications as a basis to understand cbb defects in the human cell cycle and during spermatogenesis
nextgeneration light source driving plasmas to power tomorrows nanolithography

advanced semiconductor devices are produced using extreme ultraviolet euv light at just 135nm wavelength this small wavelength enables patterning the smallest and smartest features on chips the recent revolutionary introduction of euv lithography euvl was the culmination of several decades of collaborative work between industry and science a project apollo of the digital age euvl is powered by light that is produced in the interaction of highenergy co2gas laser pulses with molten tin microdroplets the use of such lasers however leads to unsustainably low overall efficiency in converting electrical power to useful euv light delivering a watt of euv power at the silicon wafer level currently has a megawatt footprint replacing gas lasers with much more efficient solidstate lasers will significantly reduce this footprint it is currently however unclear what laser wavelength and what plasma recipe should be used this is because we lack understanding of the underlying complex physicsmoorelight will deliver the missing insight that is required to efficiently and reliably power nextgeneration solidstatelaserdriven euv light sources 1 we will obtain understanding of phase changes and fragmentation of laserimpacted liquid thin tin targets and develop capabilities for lasertailoring targets 2 we will use tailored targets to investigate how these couple to laser light of variable wavelength and spatiotemporal profile to produce hotanddense plasma this will provide insight through experiments and modeling into the optimum plasma recipe for producing euv light in tandem with efforts 3 to advance predictive plasma modeling by finding the elusive atomic origins of the euv light individually these objectives will significantly impact their related fields of science and technology combined they will enable to sustainably power tomorrows euvl and help realize the eus ambitions regarding its technological leadership in nanotechnology
city tales an artbased participatory framework for studying migrationrelated diversity

this project will study imaginaries of diversity portrayed by afroeuropean artists in lisbon and rotterdam in their films performances and oral stories these stories are not sufficiently related to in the mainstream discourses and the hypothesis is that the arts offer a particularly vibrant textual weft for exploring competing imaginaries of postcolonial urbanity the two european ports are chosen since they position themselves as opentotheworld in light of their maritime history and ensuing migration dynamic yet they significantly differ in the ways that their municipalities frame their multiculturalismi will build the framework of urban artives archives of situated stories to explore nonessentializing conceptualizations of migrationrelated diversity by close reading creative forms of storytelling interviewing and following artists in their city wanderings digitally mapping spaces of inspiration production and performance and producing two creative outputs artives will 1 trace transnational networks of belonging embodied in the local cultural scene and 2 test the possibilities and limitations in relating to these stories in ways that break away with migrantising wiest 2020 conceptions of societythis research will transpose recent developments in the field of critical archival studies namely attempts to account for the transitory nature of identity formation in records preservation to the fields of qualitative cultureoriented urban studies and migration and transnationalism studies in this way artives will bridge the symbolic material and affective aspects of how urban communities realize their sense of belonging and claim agency within highly diverse cities furthermore the project will offer a best practice for working with communitydriven knowledge contributing to the ongoing debate in cultural anthropology and cultural studies on how power relations are implicated in participatory research
future connectivity and digital infrastructure

the wa31 fcdi project aims to specify and develop the future technologies coming from the cns in order to support and manage the operational services like the 4d trajectory management in the future atm system performance requirements for cns systems are becoming increasingly complex and demanding and need to be considered as part of an integrated and holistic system of systems which includes air and ground cns solutions considering convergence towards a common infrastructure and a unified concept of operations where possible in parallel cns systems and infrastructure for both airborne and ground must take a more business and performance oriented approach with efficient use of resources delivering the required capability in a costeffective and spectrum efficient manner the ri results will enable the full implementation of concepts such as infrastructure as a service to facilitate the complete decoupling of service provision infrastructure services information services and all other anss from the physical location of the infrastructure as outlined in the target architecture specified in the european atm master plan ri need enabling the deployment of a performancebased cns service offer
tackling and investigating the southkivu mpox outbreak

with the mpox biology outcome transmission and epidemiology in south kivu mbotesk project we seek emergency funding to address one of the most alarming mpox outbreaks currently unfolding the ongoing emergence of a new lineage of monkeypox virus mpxv clade ib in south kivu democratic republic of the congo drc this outbreak is particularly concerning due to its extensive humantohuman transmission through sexual contact in a densely populated region characterized by a large sex industry and significant crossborder movement without swift intervention there is a high risk of the outbreak spreading internationally penetrating sexual networks worldwidein this project we will leverage our extensive experience with mpox outbreaks in the drc and our current presence in south kivu to tackle this outbreak through a combined approach of research and response to achieve this we will build on local and national expertise and strengthen the drcs research institutions and align with the international responsethis project has four foundational pillars each designed to simultaneously strengthen the response and comprehensively describe clade ib mpxv including its clinical presentation mode of transmission atrisk populations and virological evolution pillar 1 strengthens active case finding and epidemiological surveillance to map and monitor the spread of clade ib mpxv pillar 2 supports realtime genomic surveillance to track the genetic evolution of the strain pillar 3 enhances clinical care through an indepth clinical characterization study pillar 4 engages key populations including sex workers to study community spread vaccine hesitancy and stigma these four pillars eventually feed into pillar 5 by informing on how to best target the ministry of healths planned vaccination campaign with the modified vaccinia ankara vaccine and documenting its impact and realworld effectiveness using the established platforms of pillars 14
physical and molecular underpinnings of the multifunctionality of bacterial peptide assemblies

an important challenge in biophysics is to understand the complex biological functions emerging from the physicochemical properties of simple building blocks showcasing this challenging question is the multiple functions achieved by the phenol soluble modulins psms peptides from staphylococcus aureus able to selfassemble into amyloid structures and underlying s aureus pathogenicity over the past decade the intrinsic capacity to form fibrils in vitro has been directly correlated with the peptide biological activities in vivo this traditional focus severely limits our understanding of the role of more complex intermediate structures and dynamic interactions with the encountered biological membranes here i propose to uncover the molecular determinants and mechanisms of selfassembly and its implication in dictating psms multifunctionality from biofilm formation to inflammation and toxicity i hypothesize that beyond the current one structure one function paradigm intermediate assemblies are the membrane active entities and their coaggregation with membrane components such as lipids and proteins contribute to their distinct functions building on my prior work on psm3 and my leading force in singlecell and singlemolecule characterizations i will 1 reveal the mechanism of selfassembly and the role of lipid cofactors2 uncover the molecular modes of action of diverse assemblies at the membrane interface3 establish in vivo how these assemblies drive host cell inflammation and death4 explore the role of selfassembly in bacterial adhesion in turn biofilm formationby pinpointing the key characteristics of psms assemblies from their physicochemical to structural properties responsible for their different functions this project could set the basis for the design of novel structurebased therapeutics against staphylococcal infections eliciting less antibioresistance
mrna localization and spatial heterogeneity of translation deciphering the code within mrnp composition

mrnas are packed with rna binding proteins rbps to assemble the messenger ribonucleoprotein particles mrnps proper mrnp biogenesis export localization translation and decay are central for gene expression regulation each step requires specific rbps mediating transcript interactions with the cellular machinery so far hundreds of rbps have been identified begging the question of mrnp assembly diversity while canonical rbps are associated with all transcripts some may be accessory concurrent and specific for subclasses of mrnas what finetunes mrnp compositions is not clear and understanding how specific mrnp compositions control mrna fate is a major challenge for rna biology mrna localization and regulated translation are believed to be mechanisms to delimit gene expression to cellular subcompartments ensuring that proteins are synthesized where they complete their functions furthermore some mrnas display heterogeneous translation efficiencies depending on their localization in cells mrna localization and translation heterogeneity appear to be highly dynamic and can be finetuned upon cell differentiation or during stress these phenomena seem crucial during development particularly for large syncytial cells such as drosophila embryos but their prevalence and functions are not understood we hypothesize that mrna localization and translation kinetics are encoded by the different combinations of rbps assembling the mrnps we aim to decipher the link between mrnp composition localization and translation heterogeneity for key mrnas controlling embryonic patterning in drosophila embryos the mrnpcode project will combine mrnp capture proteomic and cuttingedge microscopy for single particle tracking and translation imaging to build a dynamic picture of mrnp composition localization and translation the project tackles longlasting questions beyond the drosophila developmental field by exploring mrnp assembly and its imprinting on mrna fates
from the paradox of individuality to the logic of representation individuals and descriptions in byzantine thought 4th12th centuries

an individual is a unique nonrepeatable entity which is discernable from all other members of the same species a theory of individuality is an explanation of the mode of being of the individualsin the aristotelian philosophical tradition which is one of the essential components of byzantine thought individuals have a particular status as primary substances they are both the ontological foundation of reality and the first object of perception i see petros not humanity but at the same time according to aristotle they cannot be defined as individuals one can only define the species to which they belong and there can therefore be no science of them but only of universals to resolve this tension commentators of aristotle active in the neoplatonic school of alexandria advanced the solution that individuals cannot be defined but can be described the greek term chosen for description hupograph has according to our research hypothesis strongly contributed to linking the logical and ontological problematic of individuality to that of representation so important in byzantium by studying the reception of the main explanation of individuality the solution proposed by porphyry that individuals are constituted by a unique bundle of nonessential properties the elaboration of the christian concept of hypostasis to designate the individual the epistemic role of accidental properties in the process of recognizing a given individual and the question of the reference of the proper name this project aims to reconstruct the theoretical issues of individuality as discussed in byzantium it will confront them with the practice of literary and material portraits in order to verify the central hypothesis of the project which is that the philosophical enquiry about individuality was in byzantium in a unique way strongly influenced by the debate about and practice of representation and that the same logic prevails in description and portrait
empirical and mechanistic foundations for synergistic predictive processing in the sensory brain

humans effortlessly process over 200 spoken words per minute in casual conversation speech recognition algorithms still fail at this challenging task our superior performance stems from our capacity to predict what the speaker may say next understanding how the brain uses these predictions to process the sensory input is crucial to understand perceptual function and dysfunction dyslexia autism and psychosis have all been linked to an impaired handling of predictionshierarchical predictive coding hpc is the current leading framework to understand how predictions help us processing sensory inputs however hpc is only compatible with the function and organisation of the cerebral cortex this is a decisive shortcoming while only cortical stages have the foresight to perform conceptually accurate predictions only subcortical stations have the temporal properties required to correctly process fast sensory inputssynprepro will reformulate hpc as an integrated theory explaining how cortical and subcortical stages work together to proficiently process fast and complex sensory inputs like speechi will use a unique experimentaltheoretical approach to study the human auditory pathway as a model for sensory pathways in four work packages wps wp1 will use cuttingedge human neuroimaging to unravel the implementation of hpc in the auditory pathway wp2 will use innovative modelbased neuroimaging to identify the mechanisms responsible for the generation of conceptually accurate and temporally precise predictions in wp3 i will develop a groundbreaking computational model to identify the neural mechanisms implementing hpc in the thalamocortical loop wp4 will use bigdata analytics to disentangle how cortical and subcortical stages work together to swiftly process speechthe outcomes will turn the cortical paradigm of hpc into an integrated theory of corticosubcortical interactions revolutionising our understanding of perceptual function and dysfunction
chemistry under force

during the last three decades physicists and biophysicists have largely exploited singlemolecule force spectroscopy smfs to advance many fields of physics nanotechnology and biology the ability to probe one molecule at a time allows us to ask and answer questions that are impossible or extremely difficult to approach by ensemble techniqueschemists did not fall into steps behind physicists and biologists and have benefited little from the advent of smfs the mechanics of bonds which is still in its infancy could largely benefit from smfs a big question like how forces and chemistry affect each other merits special attention major questions especially concerning the mechanical reversibility of bonds and bond lifetime under tension could be elucidated over the last years my group has acquired the needed expertise and has developed a range of pioneering smfs approaches that now allow us to tackle this big question requiring a considerable joint effort between synthetic chemists chemical physicists and engineers the extreme difficulty to probe bond reformation after its rupture has been a major failure of smfs for the last 25 years we propose here to solve this problem and adapt smfs to obtain a detailed picture of the mechanics and reversibility of bonds we will design synthesize and probe a series of supramolecular and dynamic covalent tethered bonds in various geometries and chemical environments the tethered structure will ensure that the partners of the bond stay in close proximity after being broken open leaving the possibility of rebinding this will offer remarkable opportunities to investigate in detail how mechanical forces and proximity can trigger chemical reactionsif we wish to gain a deeper understanding of how forces and chemistry affect each other and open new possibilities for chemical synthesis and materials science the development of smfs adapted to detailed chemistry investigations remains a frontier to be conquered