Dragon09/odtu_chatbot huggingface dataset:
aegeus a novel eeg ultrasound device for functional brain imaging and neurostimulation

the overall goal of this project is to develop a radically new diagnostic and therapeutic device for neurological applications which combines a highly innovative ultrasound component for brain imaging and focused stimulation of brain regions with advanced electrophysiological measurements of neural activityfirst goal of the project is the development of a novel ultrasound usbased functional imaging method that in conjunction with electroencephalography eeg allows for high spatiotemporal resolution examination of brain activity while eeg itself yields best data from neural tissue close to the skull the us component is designed to deliver images from deeper brain regionsthe second pillar of the devices function is focused us brain stimulation based on the possibility to localize abnormal activity the neuromodulation component of the novel device can be guided to focal stimulation of selected brain regions which can be further developed into a closedloop design the full envisioned system is a versatile tool that combines eegsensors and us transceivers in a wearable headset the project foresees the development of hard and software as well as algorithms to integrate the information from both modalities into functional neuroimaging with unpreceded spatiotemporal resolutionbeyond the technical realization this project includes a proof of concept study to evaluate and demonstrate practical applicability in healthy participants and in patients with epilepsy during clinical routine examination cognitive and sensory stimulation including testretest validation the new device will reduce the time to examine and treat neurological patients and the cost thereof the ability to perform better diagnosis via accurate imaging targeted neurostimulation and neuromodulation with a costeffective noninvasive device will have transformative effects on treatment options for neurological diseases and stimulate new lines of research in cognitive neuroscience
cellulose nanocomposite separators for the next generation of smart batteries

as the popularity of electric vehicles continues to increase so does the number of batteries reaching the endoflife that are used to power them being expected that by 2030 it will reach 2 million tons worldwide on top of this the complexity of battery production results in very high scrap rates about 1030 especially during production rampup while the scarcity of raw materials in europe are intensifying eu regulations to localize supply chains and safeguard critical raw materials it is evident that there is strong need to increase sustainability in the batteries value chain and contributions may come from improving both their lifetime and recyclability of the cell components in excell it is proposed to prove a new concept for batteries separators based on a 100 natural cellulose nanocomposite with tuneable mesopores obtained by a mixture of nanofibers and cellulose nanocrystals additionally these new separators will be suitable for the incorporation of sensing elements that will enable the new generation of smart battery cells excell will follow the outputs of newfunstg where it was demonstrated that cellulose based ionic conductive materials are possible to be recycled and reused while maintaining the electrochemical performance the pis team has also demonstrated that cellulose nanocrystals are able to create mesoporous ionic conductive channels that can be tunned to specific alkali ions but proper functionalization of the crystals surface excell will now demonstrate the synergic effect of combining both to form hierarchical mesoporous membranes exhibiting a unique set of characteristics that can meet those ones expected for an ideal separator excell will follow an approach of validating the new separator concept and then implement a ipr consolidation and a business case to attract the attention of battery market stakeholders on new opportunities for cell components based on abundant natural resources that are recyclablebiodegradable
buddhisms early spread to tibet dunhuang and the influence of sinitic scriptures

modern scholarship follows emic accounts in situating the origins of tibetan buddhism squarely in india tacitly accepting tibets claim to be heir to the orthodox tradition this oversimplifies the complex history of buddhisms two transmissions to tibet in the 7th and 11th centuries eliding the formative early contributions of sinitic sources principally imparted from the silk road oasis of dunhuang a crucial locus of interaction between tibetan and chinese cultures in the 8th11th centuries manuscripts preserved in the dunhuang caves evidence this sinotibetan nexus in native compositions and translations from chinese into tibetan efforts to trace chinese and sinotibetan influences on the formation of tibetan buddhism have been largely impressionistic but stateoftheart tools such as handwritten text recognition to digitize manuscripts allow their systematic analysis and others permit us to identify fingerprints of tibetan translations from chinese best will locate scriptures and other materials of sinitic origin and trace their impact on tibetan buddhism starting with an examination of the reasons for the prominence of dunhuang we will uncover the conditions permitting the site to become such a multicultural center cradle to a high level of buddhist scholarship identifying sinitic sources introduced into tibet in the early period we will probe their later importance challenging the traditions polemical historiography which represses such recognition we will produce a historical study addressing the background of dunhuangs scholastic buddhist culture studies of individual tibetan translations from chinese linguistic studies of the chinesetibetan lexical interface studies on the most prominent dunhuang monktranslator chos grub investigations of later tibetan historiographical works and a database of tibetan dunhuang manuscripts all contributing to a fundamental revaluation of formative influences on early tibetan buddhism
technologies and methods for improved resilience and sustainable preservation of underwater and coastal cultural heritage to cope with climate change natural hazards and environmental pollution

the thetida project approaches safeguarding and protecting europes coastal and underwater cultural heritage from the effects of climate change and natural hazards in a holistic manner that includes risk management protection and preparedness as complementary strategies to prevent damages to ch sites identify and ward off additional threats and promote policy tools for climate neutrality and economic resilience in coastal areas thetida project achieves this goal through the development of a preventive conservation strategy that includes monitoring risk preparedness and management for underwater and coastal ch ucch sites identify and ward off additional threats and promote adaptation reconstruction and other postdisruption strategies to restore normal conditions to the historic area as well as longterm strategic approaches to adapt to cc and to wield policy tools for economic resilience in this project an interdisciplinary team of researchers experts and practitioners will develop test and validate an integrated multiple heritage risk assessment and protection system with evidencebased monitoring frameworks innovative tools and instruments and through participatory processes citizens science and living labs the project implementation actions will link the social innovations with cuttingedge technologies ict and iot harmonised tools
photonatom nonlinearities and deterministic applications via arrays

the quantum properties of photons allowing lowloss longdistance transmission multiplexing large amounts of quantum information into a single channel and operations in standard roomtemperature settings yield great promise for scalable quantum computing qc however low interaction is their great weakness for quantum information processing qip as quantum circuits require photonphoton interactions to date twophoton interactions have only been facilitated either probabilistically with low efficiency or between individual photons via intermediaries with errors much too large for practical qip panda has an ambitious core goal of building the foundation for a photonic quantum computer an array of neutral rubidium atoms with subwavelength spacing carefully designed to harness collective effects to implement lossless deterministic photonphoton interactions combined with novel highefficiency singlephoton handling we will construct a powerful platform for strong efficient controllable nonlinear operations with many qip applications these include deterministic twophoton quantum gates with unprecedented efficiency and repeat rates we will especially apply our platform to continuousvariable cv qip particularly measurementbased qc which fully utilizes quantum light field advantages but has been hindered by the lack of deterministic nongaussian photon state generation and is not addressed in the quantum flagship using our platform for deterministic photon subtraction will address this and with a cv theory roadmap we will develop pave the way for photonic qc our twophoton gates will also be applicable to discretevariable qip placing panda in a complementary position to many possible portfolio projects panda incorporates worldclass experimentalists and theorists from leading research groups and smes with the expertise required to develop core technology that will both yield marketable ipr and fulfill our ambitious objectives
assessment of volatile analysis for embryo selection during in vitro fertilisation

in vitro fertilisation ivf has irrupted as the most important alternative for getting pregnant in a global world with decreasing natality rates currently ivf success rate is around 20 in order to improve it the selection of the most suitable embryo for implantation is the most important factor in the proposed project we aim to assess embryo selection based on the analysis of the volatile organic compounds vocs they emit during their development gas chromatography coupled to mass spectrometry gcms technique will be employed in the first step of the project for identifying the pattern of vocs that characterise the embryos that successfully reach the blastocyst stage as well as the blastocysts that hatch an electronic nose system which possesses several advantages over the gcms technique such as portability ease of use and considerably lower price will be next developed for the selective detection of the voc patterns identified by the gcms studies initially the study will be performed on bovine during fellows placement at the beneficiary the electronic nose that will be developed for the bovine model will be tested on humans in a realworld environment during the additional nonacademic placement of the researcher at the business partner the results of this test will constitute the basis for the future development of a reliable device for the selection of the most suitable embryos for successful ivf outcomes
a noninferiority randomized trial testing an advice of modea noninferiority randomized trial testing an advice of moderate drinking pattern versus advice on abstention on major disease and mortality

europeans are the largest alcohol consumers policymakers and clinicians are currently perplexed on how to reduce alcohol harms in drinkers due to contradictory guidelines abstention is proposed as the healthiest option by many health advocates stating that there is no safe level of alcohol intake but most nonrandomized studies found lower allcause mortality and other outcomes in moderate drinkers than in abstainers among subjects 50 years however potential biases may compromise these latter studies particularly when effects are null or moderate a large pragmatic randomized controlled trial rct of realistic advice aimed to change behavior addressing clinical endpoints is long overdue it will provide firstlevel evidence to confront the harms of one of the most widely used substances by humankind business issues and conflicts of interests are also at stake we propose a 4year noninferiority rct with 10000 drinkers men 5070 years or women 5570 years consuming 3 but 40 drinkswk to reduce alcoholassociated harms they will be randomized in a 11 ratio to 2 advices 1 abstention 2 moderation 7 drinkswk females and 14 drinkswk males and avoidance of binge drinking with preferential consumption of red wine with meals and consumption spread out throughout the week moderate consumption is hypothesized to be noninferior no participant will be invited to increase hisher alcohol intake the primary endpoint will be a global index of allcause mortality cardiovascular events cancer liver disease depression dementia diabetes tuberculosis or other major infection or injury the difficulties for feasibility are significant but more complex large behavioral trials developed by the principal investigator predimed and predimedplus two largest nutritional trials conducted in europe have attained sufficient compliance in changing not only one aspect of the dietary pattern alcohol but many aspects of diet and lifestyle
sophisticated microbubble coating materials for functional ultrasound sensing

lipidcoated microbubbles are fascinating objects rich in nonlinear dynamics they are used in medicine as ultrasound contrast agents ucas to visualize organ perfusion the contrast enhancement results from their ultrasounddriven oscillations which produce a powerful echo the echo response is sensitive to ambient pressure and the microbubble surroundings so that bubbles have potential sensing capabilities that reach far beyond their current use as contrast agents however ucas contain microbubbles nonuniform in size 110 m diameter and in shell properties the resulting illdefined echo inhibits gamechanging applications such as noninvasive pressure sensing and molecular sensing using functionalized bubbles that bind to diseased cells microfluidics allows controlled formation of monosized bubbles however even the echo response of monosized bubbles is heterogeneous due to uncontrolled shell propertiesi aim to go beyond sizecontrol and enable the microfluidic formation of functional monoacoustic bubbles with a tuned and predictable acoustic response the challenge is to bridge the gaps between fluid dynamics colloid and interface science interface rheology and acoustics to unravel the coupled problem of microfluidic bubbleshell formation and ultrasounddriven bubble dynamics in the bulk and near or targeted to a wall to reach this goal we will develop highly controlled lab experiments at the submicrosecond and submicrometer level together with simulations and theory development the ultimate goal is a physicsbased parametrization of the acoustic bubble response as a function of shell formulation microfluidic control parameters diffusive gas exchange effects and targeted molecular binding of the bubble to a boundary
digital environment for management of permits and compliance in building and construction

digichecks proposes to build a digital framework that implements the following steps to overcome the challenges mentioned and pave the way to a more streamlined approach to manage and process permitsstep 1 standardized permit ontology the first step is to create a shared language for permitting this language formalized in a permit ontology enables the framework to map data from various sources into a common structure and make it processable by a computer in a repeatable mannerstep 2 digitizing permit processes to deal with the many different actors and their respective processes for permitting digichecks proposes to develop a tool based on omg standards where these actors can model their processes into digichecks these process models can be updated and or removed when the processess change step 3 building permit rules digichecks proposed solution contains the ability for permitting authorities to build youre their own rules these rules are used as a base for an automated compliancy checkerstep 4 integration of the previous steps into a permit service api to transform the solution into a service digichecks combines steps one permit ontology two permit process and three permit rules into a service offered through an open api the digichecks permit service api implements the concepts from the ontology to defined rules and these rules are mapped to a process thus digitizing the permit workflow by having an accessible permit service third party developers will be enabled to create new innovative and reliable permitting applicationsthe ultimate objective of the solution is to provide flexibility easeofuse and efficiency to the permit validation and approval system in the construction project environments a solution framework is thus required that allows regardless of the country region or municipality an easy interoperability with the tools commonly used in construction
breakthrough cold generation technology for efficient environmentallyfriendly cooling

we have developed a new cooling technology based on the principle of adiabatic expansion compared to the traditional vapour compression technology it uses air instead of toxic hfcs to transfer energy eliminating this source of pollution and therefore reducing co2e by 50 in dac the energy extracted from the cooled air is not emitted as heat into the atmosphere but turned into electricity unlike in traditional vapor compression acrefrigeration unitsthis electricity is used to contribute up to 30 of energy required for powering up our units hence it is 30 more energy efficient compared with traditional compression systems lower opex this means that they are much cheaper to rundue to much simpler design and smaller size manufacturing costs of our devices are up to 30 lower lower capexdac tech can cool any air regardless of its humidity or initial temperature down to 90c within seconds from the start of operation and under very low pressure
revealing cellular behavior with singlecell multiomics

chemical reactions govern cellular behavior and are revealed by analysis of small molecules involved in intracellular metabolism individual cells in biological systems continuously adapt to improve survival and biological function making them chemically and behaviorally heterogeneous unraveling this heterogeneity is essential to realize the correlation to disease state and health but it is masked in bulk analyses of millions of cells i propose to develop a groundbreaking analytical approach for multiomics of living individual cells to reveal variability in cellular behavior this will be achieved by coupling a microfluidic device that enables controlled chemical exposure of a cell to an efficient ionization probe for online timeresolved mass spectrometric measurements by measuring the dynamics of each cells metabolome lipidome and secretome novel insights into heterogeneity in intracellular activities will be gained in addition the level of heterogeneity will be uncovered through correlation with the cells transcriptomea special emphasis will be given to characterize individual cells that are key regulators of blood glucose by insulin secretion and whose dysfunction leads to type 2 diabetes the behavior of individual cells is heterogeneous and ranges from complete failure to secrete insulin to compensating with increased secretion i will use the singlecell multiomics approach to test the hypothesis that intracellular metabolism is the key to cell dysfunction and analyze healthy and diabetic cells upon chemical exposure to establish i their metabolic heterogeneity and differences ii variations and temporal dynamics in their metabolic behavior and iii metabolic roadblocks that correlate with cell dysfunctionthe singlecell multiomics approach will open new horizons for understanding cellular heterogeneity realizing cellular behavior that promotes health and identifying treatment targets
multifaceted molecular mri toolbox to uncover zn2 in physiology and pathology

to reveal the multiple aspects molecular cellular and anatomical of a studied biological process in health or disease it is necessary to have the ability to spatially map the multiplexity and dynamicity of intra and intercellular events in the context of a whole organism we here propose a conceptually novel approach to spatially map the multicomponent information of a studied biological phenomenon from the deep tissue of a studied subject using a single imaging setup in realizing the importance and diverse roles of labile zn2 in specific tissues we aim to develop zincmrizincmri is a molecular imaging toolbox designed to provide orthogonal mri readouts with which we aim to monitor the multiple facets of zn2 biology through i quantitatively mapping dynamic changes in intra and extracellular levels of zn2 ii spatially monitoring zn2induced gene expression and iii providing complementary highresolution anatomical views of the studied subject to establish zincmri we will design develop and implement i fluorinated synthetic compounds as mri responsive agents for quantitatively mapping changes in labile zn2 levels using 19fmri aim 1 and ii conditional mri reporter genes for mapping zn2induced transcription with 1hcest mri aim 2 capitalizing on the orthogonality of the signals obtained with 19fmri and 1hcest mri zincmri will be applied to map in vivo from the hippocampus region of the brain both the dynamic changes in zn2 levels and the transcription of zn2 regulatory elements in response to physiological and pathological stimuli aim 3 we envision that zincmri which unconventionally aims to study two aspects of zn2 biology using a single imaging modality and is also applicable for the study of deep tissues may affect not only the way we study this ion but could also be further extended to study other metal ions with biological relevance by capitalizing on the scientific paradigm proposed here
fasttrack hybrid testing platform for the development of battery systems

current methods to evaluate liion batteries safety performance reliability and lifetime represent a remarkable resource consumption for the overall battery rd process the time or number of tests required the expensive equipment and a generalised trialerror approach are determining factors together with a lack of understanding of the complex multiscale and multiphysics phenomena in the battery system besides testing facilities are operated locally meaning that data management is handled directly in the facility and that experimentation is done on one test benchthe fastest project aims develope and validate a fasttrack testing platform able to deliver a strategy based on design of experiments doe and robust testing results combining multiscale and multiphysics virtual and physical testing this will enable an accelerated battery system rd and more reliable safer and longlasting battery system designs the projects prototype of a fasttrack hybrid testing platform aims for a new holistic and interconnected approach from a global test facility perspective additional services like smart doe algorithms virtualised benches and dt data are incorporated into the daily facility operation to reach a new level of efficiencyduring the project fastest consortium aims to develop up to trl 6 the platform and its components the optimal doe strategies according to three different use cases automotive stationary and offroad two different cell chemistries 3b nmcsic and 4 solidstate oxide polymer electrolyte the development of a complete set of physicbased and datadriven models able to substitute physical characterisation experiments and the overarching digital twin architecture managing the information flows and the trl6 proven and integrated prototype of the hybrid testing platform