Dragon09/odtu_chatbot huggingface dataset:
society ripensaci

think again change your perspective and be ready to revisit your knowledge of reality this is what ripensaci means and is our invitation to our fellow citizens the european researchers night is the perfect escape route from customary mental paths and an occasion to explore uncharted thoughts by spending one night with the researchers visitors will change the lenses through which they see things and get a glimpse of the multitude of possible points of view rethink about what we know from a different perspective is a useful necessary practice for the inhabitants of a world that is facing epochal changes and threats ripensaci also means think us again think about our place and actions within our society our economies our environment the european researchers nights proposed by the society consortium revolve once again around the responsibility of humankind on this complex planet where everything is so inextricably connected research provides excellent tools to decipher these connections and foresee the long term implications of our choices a deeper understanding of our impact is necessary to disrupt consolidated habits and allow the construction of a new reality taking advantage of a wide network of stakeholders society ripensaci will propose a variety of topics planned to engage different publics with a particular focus on kids and youngsters both editions will be held in bologna cesena cesenatico forl predappio ravenna rimini and ferrara activities will address the themes of development sustainability environment people knowledge digitalisation
quantum reservoir computing based on engineered defect networks in transition metal dichalcogenides

todays computation based on parallel processing of information is reaching its physical limitations and novel solutions are to be found in the close future to overcome such major hurdle this project aims to achieve the first proofofconcept of quantum reservoir computing qrc scheme based on networks of quantum materials qms defects which will enable the fabrication of prototypical computing devices the engineering of defect network characteristics such as density and defect typology will allow tailoring the defects network physical properties and ultimately its neuromorphic and computing complexity the project is feasible yet groundbreaking because it capitalizes upon the very different expertises both experimental and theoretical comprised within the partners consortium all of which are required to implement a novel qrc scheme as such this project will result in unprecedented characteristics that extend the conventional boundaries of ict electronic devices and systems and pave the way for the development of novel quantum technologies
expanding digital health through a paneuropean ehrxfbased ecosystem

xpandh is a csa aimed at mobilizing and building capacity in individuals and organisations to create adapt and explore purposeful use of interoperable digital health solutions based on a shared adoption of the european electronic health records exchange format eehrxf across europe this paneuropean effort will use a networkofnetworks approach ensuring that digital health actors are motivated and supported by tailored guidance and real examples to help early adopters to advance to the concrete use of eehrxfembedded digital health solutions to add value to health and care and promote personal and european health data spaces xpandh pursues the main goal of maturing and accelerating a sustainable and scalable interoperability environment for digital health innovations based on the eehrxf around 5 goals 1 to develop robust technical specifications and resources for the eehrxf building 2 to establish the xbundle readiness model 3 to verify the usefulness of the xbundle in realworld with a set of early adopters grouped under selected adoption domains 4 to mature a paneuropean digital health ecosystem of solution providers and endusers 5 to develop a framework for sustainable ecosystem the consortium will thrive on past and ongoing ehealth interoperability projects and services and particularly on the xehealth and digitalhealtheurope projects recommendations through digital health data activism and strong patient engagement it brings together 26 digital health actors under a cocreation and coimplementation concept supported by a policy board linking to governments and the ehealth network to expand its impact 10 xpanddh networks of hundreds of health stakeholders will be nurtured to form a vibrant paneuropean digital health space converging on common usable and reliable tools for real interoperable services that adoption of the eehrxf and enhance healthcare cooperation for better health towards a european health union
valorisation of food production sidestreams as multifunctional ingredients by an innovative fermentation process

green spot technologies has developed an innovative solidstate fermentation ssf process that converts large amounts of fruit and vegetable sidestreams from the food processing industry into high valueadded ingredientsthese ingredients are high in dietary fibre and complete protein low in fat and sugar free from gluten lactose and gmos and rich in vitamins essential minerals fatty acids and betaglucan prebioticscrucially ours is the first ssf process that allows for costeffective upscaling and automationin the past 4 years gst has developed this technology up to trl 6 we were able to scaleup our production of different flours up to dozens of kgweek which allowed real consumer trials during the seed fund period our value proposition has raised the interest of several large food manufacturing companies such as nestlgsts flour planet project supports the eus green deal goal of accelerating the transition to a sustainable food system farm 2 fork strategy
safeguarding biodiversity and carbonrich forest networks in europe

the eu has developed ambitious policies and regulations to halt biodiversity loss resulting from intensive use of forests and land and climate change reversing the decline of biodiversity requires safeguarding existing biodiversity and fostering the adaptive capacity and resilience of the ecosystem safenet relies on a portfolio of complementary tools to develop strategies and solutions to protect and foster biodiversity while considering the need to manage forests for climate change mitigation wood and ecosystem service provisioning safenet integrates cuttingedge methods in biodiversity monitoring and mathematical modelling with massive remote sensing and species datasets to better understand the climate change induced shifts in the distributions and migration of genes species communities ecosystems under different climate and forest and land use scenarios this will allow the prioritization and implementation of anticipatory conservation and management measures including the protection of corridors among the network of primary and oldgrowth and other ecologically valuable forests safenet implements a multiactor approach and engages key stakeholders including policymakers forest practitioners regional and national authorities certification bodies and forestvalue chain stakeholders in regional living labs developed in case study areas covering four biomes across europe and a european level policy lab stakeholders will cocreate solutions with researchers to develop sustainable strategies for real landscapes and innovate eulevel strategies and policies to reconcile conservation goals methodologies and scientific advances developed by safenet as well as the transdisciplinary teams expertise in mathematical biology remote sensing forest economy and ecology environmental conflict management policy analysis and sciencepolicy interaction and stakeholder engagement and disseminationoutreach ensure the success of safenet and its impact
stackable surface rationalization for freeform architectural design

stack will pioneer a mathematical framework and develop computational design tools for freeform surface stackability complemented by 3d elastica theory unlocking the potential for advanced digital fabrication workflows such as hot blade cutting demonstrating our technologys capabilities within the architecture engineering and construction aec sector
multicore fibers for future quantum networks

amid global uncertainties and evolving geopolitical tensions ensuring the secrecy of critical communications and safeguarding european technological sovereignty has become paramount the vulnerabilities of traditional encryption methods have already been exposed and there are indications that certain countries are already employing the harvest now decrypt later principle emphasizing the urgency for enhanced digital security measures quantum key distribution qkd offers a revolutionary approach to secure key exchange harnessing the principles of quantum mechanics to provide perfect secrecy however the widespread adoption of qkd still faces significant obstacles including compatibility issues with existing telecom infrastructure and the current low secure key rates skrrecent manufacturing advancements in multicore fibers mcf place them as a compelling answer as they offer a host of advantages for instance they provide support for spatialdivision multiplexing enabling to reach the skr capacity demands
decentralised ammonia production from renewable energy utilising novel sorptionenhanced plasmacatalytic powertox technology

the dare2x project is proposing a disruptive approach to decarbonising ammonia nh3 production development of sorptionenhanced plasmacatalytic synthesisnh3 is the chemical produced in the second highest quantities globally and is responsible for 18 of global co2 emissions furthermore its demand is expected to increase drastically in the coming decade through its huge promise as a green fuel as a result decarbonisation of nh3 production is an essential goal for decarbonisation of the eu economy by 2050 the timing is vital in starting the push for future production technologies for green nh3 to meet the expected increase in demandthe main challenges for realising european green nh3 production is to transition away from fossil fuelbased centralised haberbosch facilities to decentralised dynamic systems that can be coupled directly to renewable electricity generators at or near the point of use this does however require significant developmentsdare2x will overcome these barriers through the following gamechanging solutions i reactors utilising nonthermal plasma to drive nh3 synthesis ii novel more active catalysts using lowcrm materials iii stable and efficient nh3 sorption materials for insitu nh3 separation these innovations will be integrated into a single sorptionenhanced plasmacatalytic device that will be validated at trl4 the economic environmental and social feasibility will be assessed through lca lcc and a social acceptance studyto meet these objectives dare2x combines worldleading research institutions and innovative and rdperforming smes specialised in renewable technologies materials engineering and technology demonstrations the novel dare2x approach has the potential to make decentralised production of green nh3 costcompetitive providing european selfsufficiency of this vital future fuel and creating european scientific and innovation excellence that will spawn new companies and create jobs
rationallydesigned turbo reagents for innovative organometallics

this project aims to study the structure dynamics and reactivity of prominent alkali and alkalineearth organometallics species by ab initio and multiscale computational approaches main group organometallic compounds are cheap and mostly nontoxic therefore they are appealing to industrial processes and are employed today in an evergrowing list of reactions including drug synthesis or fertilizer manufacturing in fact little is known about their molecular structures in solution and the mechanisms by which they react hampering the development of more efficient reagents or experimental conditions this is due to their highly fluxional nature yielding a diversity of structures in fast equilibria controlled by the solvent ab initio molecular dynamics offers the best way to investigate these systems as demonstrated by recent studies unveiling the structure of a pure grignard reagent and its reaction with carbonyl substrates in a thf solution peltzer et al jacs 2020 this project expands the horizon over considerably more challenging and intriguing members of the grignard family formed by mixing metals species or solvents which show unexplained synergistic effects on reactivity and selectivity first the project will characterize the structures and reactivity mgc bond formation of mixed mgli turbogrignard and turbohauser reagents in solvent then attention will be drawn on the recently discovered remarkable synergy produced by running the grignard reaction in nonmiscible mixture of organic and green deep eutectic solvents by understanding the role of the mixed solvents for these reactions the project aims to open the route for the design of cheaper and environmentally friendly experimental conditions the project carried out in collaboration with an international experimental leader will have a great positive impact on the applicants career identifying him as one of the key players in the development of green efficient main group chemistry
modeling microbial life in polluted aquifers

groundwater pollution is a significant threat to human health and ecosystems and one of the leading causes of limited access to goodquality water resources worldwide biodegradation is an effective means to remove chemicals from the environment and several remediation techniques benefit from degrading bacteria to eliminate pollution from aquifers reactive transport models rtms have proved to be valuable tools to support remediation however efforts made so far to model biodegradation in polluted aquifers have been incomplete as they did not thoroughly consider that microorganisms behaviour in groundwater depends on their metabolism and physical interaction with the porous mediumthe microlifepaqs project aims at implementing a novel and interdisciplinary approach for pollutant biodegradation modelling as reliable support for groundwater remediation optimisation modern and newly collected microbiological omics data will constrain rtms of degrading bacteria with information about their metabolism moreover microorganisms will be considered as reactive biocolloids moving in the subsoil this omicsinformed rtm of biocolloids will be tested in a contaminated test site considering naturally occurring bacteria or injectedstimulated for bioaugmentationbiostimulationworking on this project at the delft university of technology will enrich my existing expertise with advanced skills in reactive transport modelling and microbiological analysis modelling moreover the secondment at the technical university of denmark will provide additional knowledge about innovative contaminated site investigation and advanced bioremediation strategies this transfer of knowledge will foster research and innovation on these topics as the united nations and european union strive to eliminate pollution to reduce the risk for human health and ecosystems and secure safe water resources and sanitation for everyone this project will also contribute to this global challenge
social and human centered xr

the social and human centered xr sun project aims at investigating and developing extended reality xr solutions that integrate the physical and the virtual world in a convincing way from a human and social perspective the virtual world will be a means to augment the physical world with new opportunities for social and human interactionwe will address the following limitationslack of solutions to develop scalable and costeffective new xr applicationslack of convincing solutions for mixing of the virtual and physical environmentlack of plausible and convincing human interaction interfaces in xrbarriers due to resource limitations of enduser deviceswe will develop solutions to surpass current limitations includingdevelopment of scalable solutions to obtain plausible and convincing virtual copies of physical objects and environmentsdevelopment of solutions for a seamless and convincing interaction between the physical and the virtual worlddevelopment of wearable sensors and haptic interfaces for convincing and natural interaction with the virtual environmentdevelopment of artificial intelligencebased solutions to address current computing memory and network limitations of wearable devicesthe developed solution will be demonstrated in three reallife scenarios1xr for rehabilitation after accidents or diseases2xr in the industry to increase safety and improve social interaction among workers3xr to remove interaction barriers for persons with disabilities
the role of gpcrs and homing molecules in the control and regionalization of mucosal immunity

mucosal immunity is essential to preserve homeostasis and for pathogen control within the gut and the airways the emerging dogma of immune regionalization has opened to new questions about which elements drive cell adaptation to different niches and how this can be targeted to cure diseases the intestine and the airways are functionally diverse along their length and disorders can differentially impact on different mucosal tissue regions mucosaassociated lymphoid tissues malts are located along the intestine and the airways to drain selective tissue segments and support protective immunity whether malts located in different tissue areas show immune regionalization remains poorly understood also little is known about which molecules control such immune diversity g proteincoupled receptors gpcrs are surface proteins important for cell migration and compartmentalization in lymphoid tissues but their role in immune regionalization is not clear we propose to apply a combination of imaging flow cytometry spatial gene editing and sequencing techniques to study the role of gpcrs in immune regionalization of malts at steady state and in disease in the intestine we will phenotypically and functionally profile immune cells and gpcrs expression within peyers patches pps from different gut regions in physiology or in the context of inflammation and obesity similarly we will analyze immune regionalization of bronchusassociated lymphoid tissues and noseassociated lymphoid tissues within the airways at steady state or upon infections finally we will characterize the role of a candidate gpcr gpr35 in the induction of intestinal and respiratory immunity our preliminary data show that gpr35 shapes cell recruitment to inflamed airways and influences cell positioning within pps by applying the abovementioned approaches and dedicated mouse models we will study how gpr35 regulates mucosal immunity and if it represents an attractive clinical target
development of extracellularbased artificial bionanoparticles a novel targeted vector with high potential in cancer therapy

in spite of a growing toolbox of therapies including classical radiotherapy chemotherapy or surgery and emerging immunotherapy precision medicine or hormone therapy treatments cancer is a multifaceted global health issue that continues to demand new solutions the advent of nanotechnology has added nanoparticle npsbased approaches to the available toolbox in cancer therapy indeed we now have nps with extraordinary properties including drug loading antibody functionalization and remote activation capabilities however these promising advances have so far failed to materialize in the clinic largely due to a lack of selective delivery to tumors dexter attempts to change this situation by combining recent multidisciplinary advances in the fields of nanomedicine and extracellular vesicles evs specifically dexter aims to develop new procedures to create bioartificial evs that maintain selective targeting properties after loading them with therapeutic nps these artificial evs have the potential to overcome the limitations of using native evs whose targeting and immune systemevading properties are compromised after loading with nps for this fundamental problems need to be resolved to realize their potential for application in the clinic in particular there is a clear lack of understanding regarding the stability of exosomes during longterm storage as well as their interactions with cells from the immune system in their application in vivo dexter will shed light on the key factors that govern the fate of npsloaded exosomes providing clues to modify them in order to achieve a strong enhancement of their ability for selective delivery of therapeutic loads to tumors the developing of dexter in the host institution will allow me to mature and acquire new research lines developing new competences in nanotechnology and chemical technology research and will be crucial to encourage my independency in this stage of my career
improving understanding of lung immunity in tuberculosis to establish a diverse innovative tb vaccine pipeline targeting mucosal immunity

tuberculosis tb remains one of the most devastating infectious diseases worldwide killing over 4000 people every day prevention of tuberculosis infection by novel vaccines would provide the most costeffective approach to achieve the goals of the who end tb strategy and the sustainable development goals of the united nationswhile there are few promising tb vaccine candidates available innovation by new platforms and strategies is needed to ensure that the most effective and affordable vaccines are developed tbvachorizon will innovate and diversify the global tb vaccine pipeline by pursuing four objectives1define the composition spatial organisation and functioning of protective immune responses in the mycobacterium tuberculosisinfected lung2evaluate whether mucosal revaccination with bcg and other live attenuated vaccines improves protective efficacy against tuberculosis infection in mice nonhuman primates and humans3identify host immune response profiles and biomarkers of natural and vaccineinduced immune protection in the lung4support next generation tb vaccine development by standardised headtohead testing of selected vaccine candidates in animals and the establishment of novel delivery systems adjuvant formulations and gmp platforms for live attenuated vaccinestbvachorizon will increase our understanding and develop tools pertaining to immune protection in the lung the major site of tuberculosis infection this knowledge will be exploited to develop mucosal strategies for translating towards clinical evaluation and possible implementation the interwoven activities will consolidate europes leading role in tb vaccine research and innovation with the ultimate goal of accelerated availability of affordable accessible and more effective tb vaccines