Dragon09/odtu_chatbot huggingface dataset:
plant mitochondrial genome engineering technology development and application to study fundamental aspects of mitochondrial gene expression

plamiteng has the highly ambitious overall objective to make the mitochondrial genome of seed plants amenable to genetic engineering the project consists of two complementary work packages wps in wp1 talengdm a technology for plant mitochondrial genome editing recently developed by us will be used to systematically study plant mitochondrial gene expression in vivo the focus will be on translation initiation and translational regulation in mitochondria the mechanisms of which are currently completely unknown in wp2 plamiteng will develop a technology for direct genetic transformation of the plant mitochondrial genome the mitochondrial genome is the only genome of the plant cell that due to the lack of a mitochondrionspecific selection system is not amenable to transformation and has remained recalcitrant to the insertion and expression of transgenes taking advantage of i our recent construction of a mitochondrionspecific selectable marker gene ii the generation of a dedicated recipient line for mitochondrial transformation and iii the design of a new transformation strategy referred to as multivectorial transformation that will enable the largescale testing of expression elements for their suitability to drive the expression of mitochondrial transgenes in vivo plamiteng will pursue the development of a robust technology for transformation of the plant mitochondrial genome the possibility to express transgenes from plant mitochondrial genomes will open up entirely new opportunities in both basic and applied research and pave the way to harnessing the enormous potential of mitochondrial biotechnology and synthetic biology
his enemies her rivals gendered expressions of hostility in ancient indian ritual speech and action 1000 bce

this project will chart new territory in the study of the ancient indian ritual texts of the atharvaveda av the socalled magic veda c 1000 bce because of its unorthodox elements the av has historically been overshadowed in india by the other three vedas of the high religion regarded as authoritative by later orthodox hindu currents the av has been similarly neglected in research despite the wealth of data it offers on marginal social strata through the oblique lens of its liturgical hymns this project proposes to mobilize this data through a pioneering study focusing on the indigenous category of hostile ritual it has not been noticed that while hostile ritual hymns calling for the death of an enemy exist from the point of view of both male and female agents the chronologically later ritual manual devotes the hostile ritual chapter exclusively to maleoriented hymns and makes hymns expressing womens hostility a minor topic in the womens ritual chapter do the hymns prefigure or contradict this later categorical separation by gender to answer this the hymns will be analyzed to detect any gendered sociolinguistic registers a first for linguistic work on the av and the results of this analysis compared with details on ritual pragmatics from the manual since the avs core texts are still not fully edited andor translated this entails the critical edition from manuscripts of new hymns plus the firstever translation into english of the hymns and of the relevant parts of the manual the result a case study for the dynamics of gender structuring through the prism of language and ritual evolution will be a model for the meaningful integration of gender in textbased research in terms of career development this project will allow the researcher to broaden her expertise in historical linguistics develop teaching experience and expand the interdisciplinary potential of her work beyond south asian studies
development of a firstinclass inhibitor of fih for cancer immunotherapy

we plan to carry out a valorisation project for a series of novel small molecule inhibitors of factor inhibiting hif fih that we have developed for the treatment of lung cancer as a nextgeneration therapeutic approach in the field of immunooncologythe valorisation plan will include clarification of ip rights and strategy establishing contacts with potential investors and pharma partners and verification of the potential of startup creation moreover valorisation activities will include progression of hits against fih into a lead optimisation campaign with the aim of designating a candidate drug
active inference and the circuits of precision and prediction

the human brain exhibits remarkable cognitive abilities such as imagery attention and mental simulation which along with perception reflect our capacity to infer properties of the world perceptual inference involves a statistical hierarchical synthesis of information from the senses with prior knowledge of the world there is empirical evidence in favour of predictive processing where functional interaction of descending pathways carrying topdown prediction and precision signals interaction with the ascending pathways to generative prediction errors prediction will develop a mechanistic and computational understanding of the hierarchical processing underlying inference in visionrelated human brain areas and will establish how feedback connections enable generative cognitive functions unravelling the neural mechanisms of highlevel visual cognitive functions requires novel ways of thinking about biological information processing and an integrated effort to measure and model cognitive functions at multiple brain scales predicton accomplishes this by integrating concepts and advanced methods from multiple disciplines 1 molecular biology to characterise projection celltypes 2 psychophysics and submillimetre ultrahighfield functional imaging of cortical layers and columns in the human brain 3 precision viral tracing to investigate the anatomical origins and targets of generative networks in nonhuman primates nhp 4 spatiotemporal controlled activation of genetically identified feedback pathways with optogenetics together in multiareal laminar recordings in nhps 4 biologically realistic multiscale computational modelling prediction will describe the functional circuits supporting hierarchical processing and their role in active vision this will take us to the heart of cortical function and its causative role in perception cognition and decisionmaking relative to a range of pathologies as well as to understand what makes us human
the agency of transnational strategic litigators in global governance

litigators feature in a crucial role as we confront the pressing global environmental governance challenges of the 21st century they possess an agency which is capable of driving the evolution and implementation of law across national boundaries and at the supranational level this project proposes to develop a groundbreaking explanatory model of transnational collaborations among strategic litigators which accounts for their modes of collaboration how those collaborations affect their agency in controlling the issues in their respective fields and how they negotiate complex ethical and professional challenges in their work it proposes to develop this model through the combination of comparative doctrinal research and inductive qualitative sociolegal research across four case studies of strategic litigation climate change largescale land transfers pollution caused by extractives industries and species conservation it pursues the groundbreaking aim of explaining the multifaceted and complex deliberations among transnational communities of litigators which give rise to and shape the landmark cases transforming environmental governance in diverse national contexts with this contribution to the sociology of strategic litigators the project will achieve a breakthrough in our understanding of how change can be initiated in legal systems to overcome perpetual obstacles and meet our global environmental challenges it pursues a breakthrough in understanding how litigators drive states and their legal systems to act upon their ability to govern global environmental challenges given the unlikeliness of it occurring through domestic and international lawmaking alone in sum the project aims to develop a groundbreaking model of an innovative type of agency and actor in global governance the strategic litigator collaborating across borders
emerging cooperative autonomous systems information for control and estimation

nowadays attention is drawn towards a new generation of intelligent mobile cooperative autonomous systems cass built with increasingly powerful sensors that allow them to cooperate with other autonomous systems and humans in order to accelerate the industrial ecosystem and better exploit the potential of flexible automation the cooperation of autonomous systems which is an emerging technology in many areas eg intelligent transportation systems and factory automation is done over a wireless network the use of a wireless network to connect spatially distributed systems enables flexible architectures with reduced installation and maintenance costs to existing applications while supporting the development of new applications that would otherwise be impossible the unprecedented tight coupling between control and communication due to the use of a shared wireless network and distributed decision making to orchestrate such systems introduces new challenges current modular design approaches and incremental improvements can only provide limited performance gains and may result in inefficient solutions which may lead to failures during practical deployments to effectively leverage the vast space of possibilities enabled by cass i argue that we need to fundamentally rethink how functionallycomplex cass are interconnected and operate cooperatively bridging the gap between the fields of control estimation and informationcommunication theories minerva will follow a bottomup approach to develop a fundamental yet realistic framework to establish the foundations for realtime control estimation and localization in environments where autonomous systems and humans interact minerva goes beyond the stateoftheart and targets the fundamental bottlenecks of demanding systems using methodologies fundamentally different from the existing ones aiming towards realtime control applications with communication constraints
green membrane bioseparation for circular economy

biogentle will train 12 doctoral candidates dcs with an overarching goal to propel europe to the forefront of research and development of biomolecules that can be used as highvolume commodities or lowvolume but highvalue compounds in food pharmaceutical and cosmetic industries the scientific aim of this network will be to produce and share knowledge insights and solutions to these objectives thereby enabling major steps towards and providing evidence of sustainable biomaterials production on larger scales for application in food pharmaceutical and cosmetics in europe furthermore the implementation of the actions will connect professionals of various backgrounds from academics and from industry in this network thus strengthening collaboration and discussions to bring the biomolecules separation and utilization field to the next level of the circular economy biogentle is both original and innovative because it utilizes a unique interdisciplinary approach combining the power of fundamental analysis experimentation and mathematical modeling to create a flexible bioseparation platform geared toward a green and circular economy the holistic approach from material to process is enclosed in this training network such an approach is strongly recommended for the successful development of novel membrane processes the 12 dcs will be trained and experience the complete chain from materials properties to complete process design and evaluation
engineered symbionts elucidate gut t cell memory and its dysregulation

a detailed understanding of intestinal t cell memory is crucial for novel treatments against inflammatory bowel disease but also for efficient vaccine design th cells induced by the gut microbiota are important for pathogen defence and tolerance but it is unknown whether they form immunological memory characterised by longterm antigenindependent maintenance this has been due to the technical inability of disconnecting t cell induction from bacterial persistence in the gut the gut memory project will yield unique insights into microbiotadirected th cell memory and its dysregulation through uncoupling th cell induction from luminal persistence of the microbemutant strains of nonpathogenic gut bacteria engineered to transiently colonise germfree mice will be combined with stateoftheart adoptive transfer experiments to trace antigenspecific th cells into the memory phase after their inducing bacterium has been cleared from the gut with this i aim to 1 elucidate how the longevity of such responses is regulated by host survival niches versus microbiotamediated attrition uncovering 2 how the sequence of bacterial exposures and their microbial context shape the functional repertoire of such th cells will demonstrate the impact of lineage flexibility on their protective versus pathogenic potential 3 ultimately successive transient colonisations will provide a novel approach to dissect the physiological relevance of microbiotaspecific memory th cells for the luminal microbe host protection and epithelial function these findings will aid mucosal vaccine design and indicate novel approaches to target pathogenic th cells in chronic inflammatory disordersthe groundbreaking nature of this proposal lies in the innovation of being able to uncouple microbiotamediated t cell induction from luminal antigen persistence to understand how t cell maintenance is finetuned to promote hostmicrobial mutualism while avoiding aberrant inflammation
foundations of transcendental methods in computational nonlinear algebra

polynomial equations and inequalities raises fundamental theoretical issues many of which have been answered by algebraic geometry as of applications nonlinearity is also a formidable computational challengebased on recent proofofconcept works i propose new foundational methods in computational nonlinear algebra motivated by the need for reliability and applicability the joint development of theoretical aspects algorithms and software implementations will turn these proofofconcepts into breakthroughsconcretely i will develop a theory of transcendental continuation for the numerical computation of a wide range of multiple integrals based on a striking combination of algebraic geometry symbolic algorithms and numerical ode solvers this would enable the computation of many integrals eg volume of semialgebraic sets or periods of complex varieties with rigorous error bounds and high precision more than thousands of digits building upon transcendental continuation i propose to design algorithms to compute certain algebraic invariants of complex varieties related to algebraic cycles and hodge classes far beyond the current reach of symbolic methods this surprising application is backed by a recent success on picard group computationapplications include algebraic geometry with the development of computational tools to experiment on concrete examples and build databases that document the largest possible range of behavior besides i propose applications to diophantine approximations feynman integrals and optimization
researchers careers multiple pathways

in the frame of the belgian ue presidency first semester 2024 the msca2024be conference aims to physically bring together 150 participants on the theme researchers careers multiple patwaysto achieve this a programme has been designed by four research administrations in belgium with the support of the european commission the conference will take place in mons on 18 and 19 april 2024
twodimensional magnon and spin gases in magnetic van der waals heterostructures

dimensionality plays a crucial role in the physical properties of condensed matter systems in the last century the optimization of fet technology led to the discovery of a new state of matter in which quantum mechanics fully confines any electron motion to parallel to the interfaces ie the twodimensional electron gas 2degmagnons the elementary excitations of the ground state magnetic order either ferro ferri or antiferromagnetic also carry spin in highquality magnetic materials magnons enable longdistance electronic spin information transfer magnonics has been studied extensively in magnetic bulk materials or in thin films where still several subbands are thermally populated the challenging major next step is to realize and study magnon and electronic spin transport in the ultimate 2d magnetic regimethe aim of this erc advanced project is to combine and study strictly 2 dimensional spin transport in two types of vdw magnets in a 2d magnon gas 2dmg in electrically insulating van der waals ferro and antiferromagnets and in a 2d spin gas 2dsg in proximityinduced magnetic grapheneto achieve this aim i will i fabricate high quality 2d vdw materials heterostructures and devices ii realize and study spin transport in a twodimensional magnon gas 2dmg iii realize and study a twodimensional spin gas 2dsg in magnetic graphene and vi develop new spintronics functionalities in hybrid 2dmg and 2dsg heterostructuresthis project will open a regime that has not been explored before magnonmagnon magnonphonon and magnon electronic spin interactions in 2d will lead to phenomena that are either difficult to realize in 3d such as hydrodynamic spin current flow and selfoscillations or have not yet been anticipated at all 2dmg and 2dsg controlled by gates and possibly operating at room temperature will enrich the vdw spintronics and provide new strategies for information technology including heat management
decoding tinnitus unveiling the sociopsychological cognitive and brain mechanisms

tinnitus disorder often referred to as ringing in the ears is a disabling medical condition characterized by a subjective perception of sound without any external acoustic stimulus it is linked with a range of psychosocial disturbances including anxiety depression stress irritability concentration difficulties and sleep disorders resulting in behavioral changes and functional disability given the lack of effective drug treatments comprehensive public health actions are needed first prevention requires the identification of risk factors predicting tinnitus onset and associated distress secondly improving tinnitus clinical management depends on identifying factors predicting the worsening stability or improvement of tinnitus distress over time finally understanding the mechanisms underlying tinnitus by integrating sociopsychological and cerebral aspects is crucial to better address this pathology and provide leads to find treatments we will address the methodological limitations typically associated with small datasets using two complementary datasets the uk biobank provides information on the socioeconomic background the physical and mental health of 500000 participants with longitudinal assessments the audicog dataset ensures high precision in hearing and cognitive evaluations on 300 participants with or without tinnitus we will use machine learning technics on the uk biobank data to identify i the sociodemographic psychological cognitive and health related factors predicting tinnitus apparition and evolution over time the validity of those risk factors will be tested during a clinical study performed in a tinnitus clinic we will also determine ii the cerebral patterns associated with tinnitus using machine learning algorithm we will explore the links between the cerebral patterns and the sociopsychological auditory emotional and cognitive factors with the audicog dataset to establish an integrative model of tinnitus
towards a connected history of population environmental change capital and conflict in russian eurasia 1860s1920s

land limits is a groundbreaking environmental history that explores the ecological impact of population growth in eurasia from the emancipation of the serfs in 1861 to the close of the civil war in the early 1920s a period of unprecedented mobility and demographic flux it redefines the field of late imperial russian and early soviet history by challenging assumptions that in a sparsely populated political territory stretching across a sixth of the worlds surface population pressures occurred only in the agrarian provinces of what was then european russia instead it proposes relocating to the empires borderlands and conceptualizing the empire as multiple geographicallydisparate but ecologicallyinterconnected regions an innovative method of analysing a political entity that usually resists holistic critical enquiry via a programme of nuanced critical historical research conducted in libraries and archives across five nation states the project seeks to understand both intellectual and material dimensions of the relationship between population pressure and anthropogenic environmental change and then interrogates the implications of these ecological shifts it suggests that as increased populations created changes in land use and resource exploitation so these new patterns became both the motor of economic growth via local national and global networks of labour capital and commodities and the fulcrum around which various forms of conflict emerged as land and resources became limited contested and politicised these were vital forces that transformed borderlands and became key factors in the violent collapse of the empire and the evolution of the early soviet state in doing so the project redefines scholarly debates on the nature of economic growth and of state and community violence in the late imperial period by restoring the environment as a vital category in exposing the complex causalities that connected migration capital and conflict
functionalised dense spintronics oscillator networks for neuromorphic computing

this project proposes the functionalisation of dense arrays of spintronic nanodevices called magnetic tunnel junctions mtjs for neuromorphic computing application neuromorphic computing is a field that proposes a novel computing architecture aimed at reducing energy consumption and enhancing computational capabilities compared to conventional computers it mimics the human brain where memory and information processing are physically intertwined one key component is the synapse which plays a crucial role in enabling the communication between neurons and serving as a dynamic plastic memory where the strength of connections between neurons is stored this characteristic allows for tuning these connections in a nonvolatile and reversible manner forming the foundation for intricate learning and memory processesfor this purpose the field of spintronics will be employed focusing on controlling electron spin spintronics has gained significant importance in data storage applications and spintronics nanodevices such as mtjs have recently emerged as promising candidates for neuromorphic computing due to their robustness multifunctionalities and compatibility with compatibility to metaloxidesemiconductor cmos technology they hold strong appeal for the development of artificial synapses and neurons that mimic their biological counterparts due to their low power consumption and fast switching compared to traditional transistors in addition the nanoscale size of spintronic devices allows for the creation of large neural networks the integration of memory and processing in these devices has the potential to revolutionize computational systems and strongly reduce energy consumption while increasing computational speed