Dragon09/odtu_chatbot huggingface dataset:
promoting social innovation to renew multilevel and cross sector water governance

over the last decades water governance has drastically evolved progressively moving from a resource management silo approach to the integrated water resources management the validation of innovative and cross sector governance is the forthcoming step to face the multidimensions societal challenges such as the climate change impact population growth at the global scale and ensure a safe crosssectorial water access and uses at the local scale the next chapter of water governance still needs to be framed with the clear challenge of involving equally all the stakeholders including the citizen to allow transparency inclusiveness and accountability the governance is foreseen as one major lever to support and orientate water policy and sectoral policies impacting the water sector water energy food ecosystem wefe nexus needs to be valued to embrace all the water uses in a sustainable manner across generations the main objective of innwater promoting social innovation to renew multilevel and cross sector water governance is to provide a set of digital tools and services that will be gathered in innwater governance platform to support tailored multilevel and crosssector water governance associated with economic and financial mechanisms to support eu green deal transition while ensuring water systems sustainability the innwater project will deliver a governance assessment matrix quintuple helix and citizen trust engagement framework wefe nexus economic and resources allocation simulation including household water tariff and environmental costs a selfsustaining governance community composed of 5 pilot sites in fr uk hu sp it addressing different water challenges a set of raising awareness and training tools the identification of replication opportunities in at least 14 eu basins and a set of policy regulation and economic recommendations to support eu policy implementation and new orientations
changing inequality at educational transitions

educhange aims to become one of the first ever projects to conduct simultaneous field experiments in four strategically selected countries denmark germany hungary iceland with the goal to reduce inequality at the educational transition from compulsory to secondary education and at the transition to higher education while experimental intervention studies have become more common in sociology and economics in recent years educhange will address five critical limitations in this literature 1 no information or career guidance experiment with the goal to reduce inequality at educational transitions has ever been implemented in different countries with a harmonized design this is puzzling given the importance of institutional context for the generation of inequalities in education 2 the majority of experiments focus on the transition to higher education while neglecting earlier transitions which are particularly relevant in tracked european education systems 3 previous experiments have hardly considered the role and knowledge of professional counsellors 4 previous interventions have mainly focused on updating students biased perceptions of costs and returns while neglecting other psychological and social barriers 5 advances in multimedia technologies have only to a limited extent been integrated in previous experimentskey outcomes of educhange will include a a more nuanced conceptual understanding of how career guidance and information provision can help to reduce inequalities b a comparative study of students subjective evaluation of costs returns and probabilities of success and psychological barriers they attach to different educational alternatives in a comparative perspective c knowledge about to what degree institutional context has an impact on whether information provision and career guidance can reduce inequality at two key educational transitions and potentially affect persistence at the next level
utopcycle the social movement of platform cooperatives in bike delivery

in delivery sector in contrast to the platform utopia of a datadriven business cooperative platforms oppose the utopia of delivery without exploitation nor carbon emissions this project focuses on two cooperatives rayon9 in lige and les cargonautes in paris along with one international network coopcycle its originality lies in understanding them both in the light of the concept of embedding these cooperative platforms are at the forefront of the countermovement by which society is defending itself against uberisation but this complex and multidirectional process not only engages public authorities and regulation at a local national or international level it is also emerging from below thanks to alternative socioeconomic forms such as bike delivery cooperatives this project mobilizes the tools of the sociology of work and social movements in the theoretical framework of a political economy of reembeddedness it makes the choice of an interdisciplinary approach to break down barriers between the fields of labour studies and social movement studies it goes beyond the state of the art by intending to operationalize the concept of embeddedness in the context of cyclologistical revolution it proposes an european investigation in a participatorydesign research where the problematization is built from the field this research protocol targets rayon9 and les cargonautes both specializing in the lastmile sector eg deliveries by cargo bike with electric assistance this last link in the chain is also the most expensive and the most polluting creating a real logistical headache this comparative ethnographic study is composed of two research axes first it analyses the cyclologistical transformation of bike delivery in platform cooperatives highlighting its political dimensions second it aims to understand what makes reembedding of bike delivery possible or not addressing the challenge of intercooperation
dental morphology across the tooth row geometric morphometric analysis of multiple tooth positions reconstruction of missing teeth and implications for hominin taxonomy

our understanding of human evolution depends on reliable taxonomic identification of fossils and an understanding of their phylogenetic relationships teeth are a key source of evidence they are wellpreserved in the fossil record and their morphology is under strong genetic control stateoftheart methods involve 3d morphological analysis of internal dental structures but due to statistical challenges and fossils frequently missing teeth these analyses focus on each tooth position individually this means that important aspects of variation across the tooth row are not captured and as a result key issues in hominin systematics remain unresolvedtoothrow will overcome these limitations by developing a novel methodological framework to analyse the morphology of the entire tooth row in a single analysis even in incomplete specimens i will use cuttingedge geometric morphometrics and multivariate statistics to estimate the morphology of teeth missing from fossil specimens providing a powerful reconstruction tool morphological analysis of the complete dental arcade will be developed and tested on large extant hominoid samples before being applied to two fossil hominins homo habilis and homo naledi both species are central to our understanding of human evolution yet the relationship between them and other hominins remains unresolvedthe rbased analytical toolkit developed by toothrow will advance applications of geometric morphometrics to include multiple skeletal elements with applications in fields such as palaeontology vertebrate morphology and forensics the university of vienna home to a leading competence centre in morphometrics and embedded in large networks of anthropological and evolutionary research is the ideal host for this project results will be disseminated to a broad range of audiences through scientific conferences publications in highimpact open access journals an opensource r toolkit and outreach activities
revealing the hidden mechanism of room temperature relaxation in glasses

glassmakers have known since ancient times that rapid cooling of a viscous liquid makes it stop flowing and transition into a solid glass state glasses are not in thermodynamic equilibrium and consequently their properties change over time as the structure relaxes toward a lower energy state at room temperature rt the glass state is believed to be frozen and remain almost forever 1010 years however recent stain measurements on aluminosilicate glasses have shown that the dynamics are not fully arrested at rt that is rt relaxation occurs and leads to changes in glass volume and enthalpy thus challenging the current consensus on glass relaxationin this project we will decipher the linkage between structure and rt relaxation in selected glasses with different types of chemical bonding the aim is to reveal the hidden structural mechanism behind rt relaxation to this end we will first elucidate the composition dependence of rt relaxation modes and subject the glasses to varying degree of relaxation to identify the crossover temperature of relaxation modes then the structural evolution associated with relaxation will be tracked and the corresponding atomic configurations will be constructed finally we will perform rigidity and energy landscape analyses to reveal the connection between glass network topology and propensity toward rt relaxationthe project builds on complementary expertise of the fellow applicant structure characterization atomistic simulations and supervisor relaxation glass science together with the research and training environment provided by the host organization aalborg university denmark this will ensure the achievement of this timely and innovative project as well as the dissemination and exploitation of the expected results the research outputs will deepen our understanding of glass relaxation the fellow applicant will emerge from the project with new skills and the capability to launch his own research group
seismic risk reduction and adaptation for complex timedependent industrial systems

adapting to the increasing threat of natural hazards is one of the most pressing current societal issues specifically seismic risk reduction and adaptation of complex intertwined industrial facilities are keys for an effective eu green transition nevertheless the most common policies still rely only on static risk analyses neglecting temporal and spatial interactionsin fact no one has yet tackled the critical aspect of industrial system adaptation accounting for the dynamics of the hazard of the system itself and its recovery processes this comes with no surprises as system adaptation is a highly complex stochastic process deeply rooted into the future where uncertainties at all levels play a crucial role this critical research gap is filled with the seismic risk reduction and adaptation for complex timedependent industrial systems reactis project which is the first integrated uncertainty quantification uqbased methodology that aims to solve these open questions the project will examine the stochastic dynamics of the performance of industrial facilities subjected to timevariant seismic hazards in particular the recovery processes of the systems will be deepened and treated from a uq and stochastic dynamics perspectivebuilding upon preliminary collaboration the project will focus on the stochastic dynamics and recovery of a single 1node system then a realworld complex industrial case study will be deployed leveraging concepts from spatial statistics and graph theory the intertwined network topology of the industrial system will be mapped specifically the evolution of the dynamics of the system will be extended to a mnodes initially deterministic then random network configuration finally our research will encompass an indepth analysis of seismic risk and adaptation strategies formulation this effort aims to identify the criticalities and vulnerabilities within the industrial system networks
mitochondrial dna homeostasis in growing cells

mitochondrial dna mtdna constitutes a substantial proportion of dna in eukaryotes and its regulation is critical not only for mitochondrial function but also for cell survival however it is still unclear how mtdna copy number is maintained during cell proliferation and how mtdna copy number impacts on cell function recently my group showed that in budding yeast mtdna copy number is tightly linked to cell volume to maintain constant concentrations providing an elegant and potentially conserved strategy for mtdna homeostasis but how is mtdna coupled to cell volume based on my groups work we proposed that nuclearencoded mtdna maintenance factors produced in proportion to cell volume limit mtdna replication and stability this provides a conceptual mechanism for how cells link mtdna copy number to total cellular protein content and opens the door to a quantitative and molecular understanding of mtdna homeostasiswith mitosize i will reveal the molecular basis of this limiting machinery mechanism to test whether the mechanism is conserved across species and to chloroplast dna i will use two evolutionary distant eukaryotes s cerevisiae whose size i can control genetically and c reinhardtii whose size i can control with light i will use an interdisciplinary approach combining molecular biology quantitative livecell imaging and modelling to develop a quantitative understanding based on measurements of mtdna replication and degradation i will then unravel the contribution of the limiting machinery regulation to the dynamic adaptation of mtdna to changing environments moreover by breaking the coupling of mtdna copy number to cell volume i will dissect how cell volume and mtdna copy number determine cell function and aging by identifying the molecular regulation underlying organellar dna homeostasis i will address a fundamental question in cell biology and open the door to new intervention strategies for mtdna misregulation in diseases
agroforestry business model innovation network

the overall objective of af4eu is to promote the european af through the development of a multiactor interactive and innovationdriven expanded agroforestry network this will be based on the sharing of successful practical experiences and existing research knowledge applied to different and new territories climates and agricultural sectors connected through icttools with a special focus on the development and implementation of new costeffective practices business models and afextension services considering the whole food chain and therefore including consumers all af4eu partners have associated networks of af farmers policy makers and advisors thanks to their leadership of the european agroforestry association national network and others are large farmers association itself eg efi that will be an essential part of the 11 regional agroforestry innovation networks including relevant actors and specially operational groups the andalucian ministry of agriculture as policy maker is also part of the consortium a set of 33 successful af farm business models will be analysed across europe from a sustainability perspective economic environmental and social the project builds up on previous h2020 projects and aims at developing an af knowledge platform that integrates a enduser i searchable knowledge reservoir namely knowledge cloud ii an alivehandbook iii an agroforestry innovation business decision support tool afibus dss including a business and a business environment analysis targeting af policy in europe and a multilingual massive open online course mooc with training modules targeting farmers and advisors af4eu will definitively contribute to the implementation and uptake across europe thanks to the supply of costeffective business models techniques and a successful communication dissemination and exploitation planning reaching a large audience in europe
development characterisation of a prevascularised tubular scaffold for tracheal regeneration that supports the formation of an ipscderived epithelium

tracheal damage is often lifethreatening and its incidence has increased due to invasive mechanical intubation of covid19 patients short defects undergo a surgical procedure anastomosis but this is not feasible for extensive defects while bioengineered approaches for such defects have been investigated there has been little translation into the clinic as implants weaken over time and fail to support the formation of neotracheal tissues i aim to solve this problem by developing and characterising 3d printed tubular scaffolds for use as medical devices for tracheal restoration via a global fellowship involving royal college of surgeons in ireland and boston university followed by a nonacademic placement in cellink scaffolds will be designed to mimic tracheal biomechanics and will be extensively characterised induced pluripotent stem cells ipscs will be used to develop a prevascularised mature respiratory epithelium on disc scaffolds in combination with endothelial progenitors and human mesenchymal stem cells hmscs the triculture will then be moved into the tubular design and the prevascularised mucosal substitute will be grown and assessed in vitro as an approach for ex vivo seeding of tracheal grafts prior to implantation the ability of the tubular scaffold to support the growth of cartilage tissues will be assessed using a combination of bioprinting and differentiation of hmscs itrach will provide me with crucial training in advanced research skills ipscs stem cell biology biomaterials 3d printing and transferrable skills intellectual property project management entrepreneurship professional enhancement and science communication this fellowship will provide me with the required technical and complementary skills to enhance my employability and to allow me to transition into a research position in a leading biomedical company while also allowing for the possibility of me staying in an academic role with links to industry
ai4soilhealth accelerating collection and use of soil health information using ai technology to support the soil deal for europe and eu soil observatory

the objective of ai4soilhealth is to codesign create and maintain an open access europeanwide digital infrastructure compiled using stateoftheart artificial intelligence ai methods combined with new and deep soil health understanding and measures the aibased data infrastructure functions as a digital twin to the realworld biophysical system forming a soil digital twin this can be used for assessing and continuously monitoring soil health metrics by land use andor management parcel supporting the commissions objective of transitioning towards healthy soils by 2030 the project is divided into seven 7 workpackages including wp2 policy and stakeholder engagement networking and synchronising with eu and national programmes wp3 soil health methodology and standards developingtesting methodology to be used by wps 46 wp4 soil health insitu monitoring tools and data developing field and laboratory solutions for observations measurements wp5 harmonised euwide soil monitoring services developing the final suite of tools data and services wp6 multiactor engagement pilots organizing fieldworks and collect users feedback wp7 soil literacy capacity building and communication organizing public campaigns and producing educational materialskey deliverables include 1 coherent soil health index methodology 2 rapid soil health assessment toolbox 3 ai4soilhealth data cube for europe 4 soilhealthsoildegradationmonitor and 5 ai4soilhealth api and mobile phone app produced tools will be exposed to targetusers including farmer associations in 10 countries so their feedback is used to improve designfunctionality produced highresolution paneuropean datasets will be distributed under an open data license allowing easy access by development communities ai4soilhealth will provide an effective soil health index certification system to support landowners and policy makers under the new green deal for europe
ancestral molecular function of polycomb repressive complex 2 prc2 in green algae lineage

polycombgroup pcg proteins assemble into complexes to maintain cellular identity in multicellular organisms and regulate phase transitions in plants by epigenetic gene repression polycomb repressive complex 2 prc2 is one of the complexes that is evolutionary conserved and catalyzes trimethylation of histone h3 on lysine 27 h3k27me3 prc2 is extensively studied in flowering plants where it determines cell fate during development reports predicts putative homologs of prc2 subunits encoded in the genomes of unicellular green algae but no molecular evidence of prc2 complex composition targeting and function is available the main goal of pamfgal project is to describe the molecular functions of prc2 in the green lineage to elucidate its ancestral roles it will examine histone modifications in in three trophic states of green algae using chip rna and bssequencing and determine their impact on the transcription level of genomic elements by utilizing transgenic algae and complementation of moss coupled with histone modification analysis the project will investigate prc2 activity conservation in the green lineage it will characterize prc2 complex composition using coip and fret microscopy phenotypic analyses of prc2 subunit knockout mutants will elucidate the functional role of prc2 in growth and reproduction of green algae understanding of epigenetic regulation in growth and metabolism of unicellular green algae will contribute to more efficient ingredients production rafa krela will be based in the group of dr iva mozgova biology center cas focused on epigenetic regulation of photoautotrophic development and evolution of the prcs training will involve algae cultivation bioinformatical analysis molecular biology and epigenetic methods and the applicant will take part in leadership and project management training as well results will be presented at scientific and industrial conferences and in highprofile scientific journals
deciphering commensalhostpathogen metabolic interactions to combat intestinal infections

our intestinal tract offers an attractive environment for bacteria the beneficial bacteria of our microbiota feast on undigested foods and provide numerous health benefits enteric pathogens see this environment as an entry point for infection both groups influence each other creating a tripartite interaction with us the host understanding this interaction represents an emerging research area to combat infections poised to improve human health bacteroides are key commensals in these triangular interactions as they produce diffusible intermediates as part of their metabolism that are utilized by pathogens and the host these metabolites arise from the action of 100 polysaccharide utilization loci pul that have been a major focus from biochemistry to gene regulation while the field has focused mostly on transcriptional pul control recent work from my group and others demonstrated that bacteroides employ noncoding rnas to regulate metabolic genes these insights raise the questions what is the mechanism by which noncoding rnas regulate pul and how do these mechanisms fit within the tripartite interaction between bacteroides the host and pathogens in gutcheck i hypothesize that pul regulation integrates transcriptional and rnamediated posttranscriptional control which in turn shape the outcome of hostpathogen interactions to test this hypothesis i will answer three specific questions 1 how is pul expression regulated2 how does pul regulation impact interactions with pathogens and the host 3 to what extent can pul regulation be manipulated to thwart pathogen invasion the proposed work will incorporate a threeway model for bacteroides host tissue and a pathogen along with modern techniques such as crisprbased screens and triple rnaseq the functional insights gained will establish fundamental understanding of hostmicrobiotapathogen interaction and may lead to novel rnabased treatments for intestinal infections