Dragon09/odtu_chatbot huggingface dataset:
a multiplexed plasmophotonic biosensing platform for rapid and intelligent sepsis diagnosis at the pointofcare

ambrosia aims to provide the foundations for a multisensing futureproof point of care unit for sepsis diagnosis offered by a cmos compatible toolkit and enhanced by onchip photonic neural network technology to provide an accurate and rapid diagnosis ambrosia will be investing in the established ultrasmallfootprint and elevated sensitivity of integrated plasmophotonic sensors reinforced by the wellknown onchip slowlight effect and microtransfer printed lasers and photodiodes on si3n4 as well as the functional processing and classification portfolio of integrated photonic neural network engines towards painting the landscape of the nextcoming disruption in sensor evolution tailoring them in systeminpackage prototype assemblies with the sensors being cheap disposable pluggable modules that can rapidly and accurately diagnose sepsis at the bedside in clinical environments ambrosia targets to demonstrate a point of care unit incorporating i a switchable sensor area array with each sensor area facilitating a pluggable 8channel labelfree plasmophotonic sensor for sepsis diagnosis with a sensitivity over 130000nmriu and a limit of detection below 108 riu for each interferometric sensor ii an embedded si3n4 photonic neural network processing and classifying at the same time the data from at least 7 biomarkers with zeropower providing in the first minutes an accurate and rapid diagnosis for sepsis iii microtransfer printed lasers and photodetectors on chip that will drastically decrease costs of both the sensing and neural network modules and render the sensor arrays disposable
tracing human cortical neurons involved in epileptic processes at multiple scales

epilepsy is one of the most common chronic neurological diseases in humans affecting 50 million people worldwide this brain disorder is characterised by hypersynchronous neural activity resulting in seizures abnormal recruitment of cells induces unusual behaviour sensations or loss of awareness epilepsy has a substantial economic effect on health care needs or the loss of productivity in workinvestigating the role of different neuron types in generating pathological activities is essential for identifying what makes a brain region predisposed to generate epileptic events most information regarding the properties of neuronal circuits during epileptic activity comes from animal models however recent studies have shown substantial differences when comparing human tissue to animals and epilepsy models to disease i aim to utilise a unique multilevel approach to follow how neurons are recruited into epileptic events and categorise them at an unprecedented level of detail in human epileptic patients i plan to analyse cellular activity in recordings obtained in vivo and characterise human cortical neurons in vitro with simultaneous intra and extracellular electrophysiology completed with post hoc histology this will be the first study examining neuronal behaviour and subtypes in the same epileptic patients both in vivo before surgery and in vitro after surgery this innovative approach will provide valuable information on the role of the different neuron types in the generation of epileptiform activitythe fundamental knowledge of the cellular mechanisms of epileptic events specific to humans could help us understand the human disease deeply and thus achieve a significant breakthrough in epilepsy treatment enhancement in the diagnostics and cure of epilepsy would considerably decrease the cost of medical care and promise an invaluable improvement in the quality of life on the individual level
seawater hydraulic pto using dynamic passive controller for wave energy converters

the shy project will develop a composite linear pump and controller valve that use seawater as the working fluid and enable the use of a dynamic passive controller to maximise the power capture a dynamic passive controller involves the dynamic control of active energy ie only damping forces this has been shown to provide a significant increase in power capture relative to optimum linear damping without the requirement to provide additional reactive energy the performance of this control strategy and associated technologies will be proven by applying it to the wavepiston wave energy converter however it is expected to be equally suitable for a wide range of wave energy converters that utilise a hydraulic pto a numerical model of the system will be constructed and used to develop a control strategy designed to minimise the levelized cost of energy rather than maximise power capture which is a common but suboptimal objective for many control strategies the control strategy will first be calibrated and validated using a hardwareintheloop test programme and subsequently validated using the wavepiston offshore test bench at plocan two generations of the linear pump and controller valve will be fabricated designed for mass production with consideration of its full lifecycle impacts although the actual prototypes may use low volume techniques to limit project costs the second generation prototypes will be based on learning from experiences and the performance of the first generation a condition controller designed to increase the remaining useful life and thus reduce the lcoe will also be investigated this will include identifying condition signatures that indicate a deterioration in one or more components and then using this signature to first estimate the remaining useful life followed by identification of modifications to the control strategy to extend the remaining useful life
storytelling as pharmakon in premodernity and beyond training the new generation of researchers in health humanities

storypharm will deliver an international interdisciplinary and intersectoral programme of doctoral training recruiting 15 fellows who will become highly skilled cultural historians specialising in premodern intellectual and healthcare worlds grecoroman sasanian byzantine western medieval and islamic acquiring interdisciplinary knowledge in classics medieval studies narrative medicine health humanities and medievalism along with transferable skills the fellows will be able to use develop and deploy cuttingedge approaches to storytelling and its ethical ramifications for scientific professional business healthcare and social purposes the consortium of storypharm will comprise 5 universities across europe ucy uni ba lu cu uni sa it will also have 7 associated partners including nonacademic and nonprofit institutions businesses and health and pharmaceutical actorsstorypharms research objectives and training programme including secondments in both academic and nonacademic environments will expose the fellows to a variety of research training and work settings by integrating interdisciplinary and transdisciplinary methodologies and engaging leading experts from various fields storypharm will deliver an innovative phd programme that will go beyond the standard phd curriculum in the humanities the combination of academic and handson training associated with exposure to diverse settings will produce a critical mass of young specialists with exceptional career prospects in academia industry and the healthcare sector these specialists will be ideally positioned to 1 achieve groundbreaking research results 2 meet current trends and needs in the job market 3 work towards establishing a humancentred medical system and 4 create better and more resilient societies storypharm will establish the field of premodern health humanities and address the need for a dialogic and empathetic approach in the healthcare sector
salami sapphire and diamond labonachip microfluidics microreactors for extreme conditions experimentation

extreme conditions ie high pressures high temperature hpht or harsh chemical environments are extremely difficult to study and to observe undisturbed in the field and to replicate in the laboratory this critically slows down the rate of discoveries both for several industrial processes or in environmental sciences new types of transparent reactors are needed to implement fastscreening to speed up experimentations in harsh conditions while microfluidics could address these limitations current solutions do not propose simultaneously high pressure high temperature capability chemical inertness and transparencya new microfabrication technology developed in the erc cog big mac project allowed the development of an innovative microfluidics platform made out of sapphire for pioneered applications in hp microbiology and bioprocesses insitu characterisation of geo and hp bioprocesses over a broad range of pressures 300 bar and temperatures 200c in the erc poc salami project i aim to extend this concept to a new family of microfluidic devices based on sapphire and diamond to meet the actual needs of potential endusers kbar 700c these microfluidic reactors will be highly disruptive because they are both uniquely transparent and resistant to harsh pressure temperature and chemical conditions the erc poc salami project will extend the frontiers of microfluidics with marketready extreme conditions plugandplay and userfriendly labonachip for labscale and fieldbased nonspecialist applications it will enable measurements in extreme environments in multiple areas that do not currently benefit from microfluidics thus opening new lines of questioning for research and simplified and cost effective diagnostic tools for industry while hpht technologies miniaturisation and fast screening capability can greatly reduce costs for process optimisation
efficient verification of quantum computing architectures with bosons

quantum devices offer great promise for computation cryptography communication and sensing alternative approaches to quantum information processing in which bosonic modes are the carriers of information have attracted increasing attention because they offer a hardwareefficient path to faulttolerance and scalability thanks to their inherently large hilbert space however this poses the problem of providing rigorous guarantees of the correct functioning of these promising bosonic architectures a task known as quantum verification to date this verification is performed by generalpurpose tomographic techniques which rapidly become intractable for large quantum systems thus other methods are needed as quantum devices are scaled up to achieve realworld advantagesveriqub will introduce a new approach to the verification of quantum computing architectures with bosons based on continuousvariable measurements veriqubs technological toolbox will comprise two main elementsi we will experimentally demonstrate the verification of multimode bosonic systems for optical and superconducting architectures well beyond the stateoftheart and provide the first demonstration of verified quantum computational speedupii we will develop a theory framework that defines the fundamental advantages of our contribution putting special emphasis on identifying and verifying resourceful bosonic quantum devicesthe veriqub consortium comprises world leading scientific partners who are ideally positioned to achieve the ambitious vision of this project and build a stateoftheart verification technology toolbox enabling bosonic quantum computing architectures to scale up and positioning europe as a leader in this domain
investigating the genome and transcriptome dynamics of early interspecific hybridization

hybridization has shaped the evolution of every kingdom of life by combining highly diverged genomes hybridization can drive genetic exchange across lineages hybrid genomes often present hallmarks of genome instability but direct proof of higher rates of mutational events are lacking what triggers genome instability in hybrids and when it arises remains a mystery to address this question i propose to investigate early hybrid history i seek to conduct a comprehensive characterization of hybrid lethality genome stability and gene expression employing saccharomyces yeast as a model due to their tractability and ability to form hybrids despite extreme sequence divergence between parental founders these studies will focus on the early phases of interspecies hybrid clonal expansion that immediately follow zygote formation i will first quantify how parental divergence in conjunction with environment influence the genome stability and viability of asexually expanding hybrids next i will combine ultralong read dnasequencing with singlecell rnasequencing to assess the structure and complexity of hybrid genomes how they evolve over time and the genomic heterogeneity of hybrid cell populations with singlecell resolution finally by conducting transcriptomic analysis of clonally expanding hybrids i will determine gene expression dynamics at the onset of hybridization and whether the parental subgenomes converge toward similar gene expression signatures to enter the aforementioned stabilization phase mechanistic characterization of the interaction between hybrid viability genome instability and gene expression phenotypes will provide an unprecedented view of how early hybrid genomes arise are maintained and evolve
receptor recruitment as an organizational principle for selfassembling matter

receptor recruitment occurs in biology as a response to binding for example by virus particles to a cell membrane the interactions that underlie the binding process are typically multivalent in nature in other words multiple interactions of the same motif occur simultaneously to provide a collective cooperative effect this project aims to employ recruitment as a design criterium for selfassembling building blocks into welldefined architectures intrinsically weak and dynamic interactions are essential in achieving selfassembly and recruitment exquisite control over stoichiometry and structure of the assemblies is achieved by harnessing groundbreaking developments in the understanding of these multivalent interactions followup fixation processes will be developed to transfer the molecular organization onto stable building blocks and materials functional eg fluorescent groups will be implemented into the systems to provide insight into recruitment and selfassembly processes these breakthrough insights will be used tackle challenges with the identification sensing and isolation of biological particles highthroughput methods will provide technology to screen multiple virusglycan combinations with the aim of providing fingerprints of viruses based on their binding behaviour platforms with nanoscale dimensions and molecular functionalities will be prepared which will be used for singleparticle sensing and particle isolation of for example virus particles and extracellular vesicles as such this proposal takes inspiration from nature by borrowing recruitment as a concept to build selfassembled materials and to contribute to a better understanding of living systems using new detection and isolation tools with application prospects for biomedical platforms and smart materials
landbased automated recirculating aquaculture

in order to improve food security and climate resilience blue planet ecosystems bpe aims to decouple the production of animal protein from the ocean by turning sunlight into seafood it is the companies vision is to establish largescale autonomous aquaculture operations in deserts and urban environments with no environmental impact on a scale that is able to feed cities and countries
plasmonenhanced nanochannels for protein isoforms tracking and identification

singlemolecule protein sensing and sequencing technologies are emerging on the horizon as new powerful tools which ultimate goal is the characterization of the proteome namely the total set of proteins made by a cell or organism despite recent advances challenges in terms of fulllength reads high throughput and intrinsic complexity related to the larger set of building blocks ie 20 amino acids still remain furthermore the unambiguous identification of proteins at low concentration is an open issue for conventional techniques such as mass spectroscopy and elisa i aim to develop a plasmonenhanced singlemolecule sensing device to track and identify proteins combining a dualcolor aminoacidspecific technique to label the proteins and the enhancement to the fluorescence provided by properlydesigned plasmonic nanostructures integrated within a nanochannelbased device the plasmonic nanochannel is filled with a custommade gel to slow down the motion of proteins and separate them by their molecular mass during the electrophoretic migration meanwhile plasmonic nanostructures enhance the fluorescence signals acquired from each individual dualcolor labelled protein i will focus on the optimization of the device and testing its capabilities for the discrimination of clinicallyrelevant isoforms of vascular endothelial growth factor vegfa family i will tackle the challenge of isoforms identification even further by using the device to discriminate between vegfa and vegfb which differ for only six amino acids at the c termini results from this work will provide a technique for the identification and quantification of protein isoforms with singlemolecule resolution potentially the use of this diagnostic tool will provide new insight into the role of vegf isoforms and their updown regulation into several diseases and in turns also new avenues for targeted therapeutics
endoscopic brush cytology and single cell clinal dynamics of early easophageal adenocarcinoma for detecting cost effective surveillance strategies and prediction of cancer recurrence

in many european countries the recent rise in incidence of esophageal adenocarcinoma eac is without precedent eac is notorious for its highly aggressive biological behavior leading to invasive disease and early metastases the only way to reduce mortality is through treatment in early stage of the cancer eac has a well recognized premalignant precursor lesion identified as esophageal metaplasia or barretts esophagus be which offers important opportunities for treatment in early stages of cancer which may reach 5 years survival rates up to 80 however these patients need to be monitored constantly for timely intervention in case of disease recurrence or metastases the problem is that after endoscopic treatment up to 30 of cases will develop recurring cancers or even present with metastases which requires additional endoscopic treatments or surgery currently it is impossible to predict which of the treated be patients with will have stable disease and which will recur or progress to invasive cancer as a consequence all treated patients need to remain in frequent endoscopic surveillance this leads to overtreatment of a large group of be patients and undertreatment of those with more aggressive disease there is a low cost effectiveness of endoscopic therapies low quality of life of patients and poor satisfaction of care providers an accurate risk stratification method for early aec in be patients is therefore an unmet clinical need the ambition of the endeavor consortium is to implement an innovative risk stratification method which encompasses minimally invasive cell collection supplemented by single cell genomic analysis to address this specific need taking into account patient characteristics gender dimensions an optimal model model will be tested in a randomized controlled prospective trial future implementation of this method will reduce health care costs increase quality of life and satisfaction of health care providers this action is part of the cancer mission cluster of projects on diagnostics and treatment diagnostics
qed factorization for exclusive semileptonic bmeson decays

exclusive semileptonic b decays provide an important laboratory for measuring fundamental parameters of the standard model sm or to search for yet unknown particles and interactions various tensions between experimental measurements and sm predictions have been guiding the theoretical efforts over the past yearsto draw reliable conclusions from the anticipated experimental highprecision data for such decays in the coming years requires a rigorous study of subleading corrections that have been neglected so far with the proposed action the researcher aims to investigate the impact of socalled structuredependent electromagnetic corrections to kinematic distributions in semileptonic b decays using modern effective field theory and factorization methods a systematic study of qed corrections along these lines is a relatively new field of research and in certain cases revealed surprising enhancement mechanisms not captured in a pointlikemeson description an analysis of these effects in semileptonic transitions at the differential level is ambitious and phenomenologically interesting photon couplings between the charged leptons and the meson constituents might lead to enhanced effects in rates or angular distributions uncertainties from novel hadronic parameters must be added to clean ratios with reduced hadronic uncertaintiesconceptually factorization is achieved using of softcollinear effective theory and heavyquark effective theory the analysis of these decay amplitudes require modern subleading power techniques to deal with technical difficulties such as endpoint singularitiesthe action is subdivided into four workpackages wp factorization theorems for charged and neutralcurrent semileptonic transitions are derived in wp1 and wp2 respectively novel concepts regarding the treatment of endpointsingularities are developed in wp3 and wp4 aims at a collinearphoton inclusive jetlike treatment of electronic channels
translating a new metabolic engineering strategy to industrial biotech applications

industrial biotechnology plays a key role on the road to a sustainable climateneutral and circular economy however disruptive innovations are needed to substantially increase the efficiency of biobased processes for the production of chemicals the erc cog project strainbooster aimed to develop a generic metabolic engineering strategy to maximize the productivity of microbial cell factories it is based on the concept of enforced atp wasting eaw a targeted intervention in the energy metabolism of the cell that enhances the overall metabolic activity boosting also product synthesis the project reached its central goals and could demonstrate in several case studies the enormous potential of eaw to improve productivity up to tenfold increase and product yield with these results strainboosters innovation is now mature to initiate a transfer from smallscale example processes in an academic lab to realistic industrial applications this is the goal of the poc project transmetech two companies one younger startup colipi and one established big biotech player basf have already indicated their high interest to collaborate with us within this poc project to jointly explore the potential of eaw for their innovative bioprocesses oil production by oleaginous yeast colipi and synthesis of terpenoidbased products basf in addition to further improve the efficiency of eaw in industrial applications we will validate different expression systems for autoinduction of eaw in twostage processes which are also directly relevant for our partners in summary through transmetech we will establish partnerships with biotech companies to facilitate the translation of the strainbooster approach and showcase its power in concrete industrial applications on the long run our method will enable higher efficiencies of commercial bioprocesses and thus contribute to the establishment of sustainable production routes one of the most urgent societal challenges