Dragon09/odtu_chatbot huggingface dataset:
integrating adaptive learning in maritime simulatorbased education and training with intelligent learning system

while all educational sectors have been affected by the covid19 pandemic the vocationaloriented academic training components in higher education sectors have been more severely affected than others for undergraduate and graduate students studying for a career at sea the pandemic has led to suspension to their simulator training sessions vocational learning opportunities and future careers the simulatorbased education and training domain which forms the platform of skilled manpower supply for the maritime industry faced unprecedented challenge to ensure the continuity of the educational activities and to cope with the constraints imposed by the pandemic highquality vocational education is the cornerstone of effective youth transitions into the labour market for the european society the disruption of simulatorbased training and tutoring sessions has led to concerns regarding whether the higher and vocational educational institutes can produce a sufficient and competent workforce who could adequately carry out onboard navigation functions safely and efficiently in the near future by accounting for the needs knowledge gaps and challenges faced by todays maritime education and training sector the imaster project aims to integrate emerging technologies in vocational education and training to develop an innovative intelligent learning system ils with maritime learning analytics and adaptive learning function to facilitate both remote and onsite maritime simulatorbased education and training the imaster solution will significantly enhance the effectiveness and accessibility of simulatorbased education in the european society and further improve safety security and performance of maritime operations of the future
targeting mfrn2 to inhibit metastatic cancers

metastasis formation is the leading cause of death in cancer patients thus there is an unmet need for drugs that can prevent andor treat systemic metastases we have discovered that breast cancer cells rely on a solute carrier slc transporter for metastasis formation in lung and liver interestingly systemic inhibition of this slc transporter using a therapeutic modality has likely a favorable toxicity profile because knockout mice are viable and have very few and minor phenotypic changes therefore wehypothesize that targeting the slc transporter can be exploited to inhibit metastatic growth to valorize this slc transporter as a drug target we will 1 perform a detailed mechanistic analysis of its function in samples from breast cancer patients 2 define the efficacy profile of the inhibition of this slc transporter against systemic metastasis in mouse models 3 translate the slc transporter inhibitionbeyond breast cancer 4 determine the efficacy and safety of targeting metastatic patientderivedxenograft pdx with antisense oligonucleotides asos against this slc transporter and 5 delineate a strategy to define small molecule inhibitors against the slc transporter to do so we will apply multiplex immunohistochemistry in samples from breast cancer patients and perform stateoftheart metastasis assays in allograft xenograft and pdx mouse models thus we will deliver a comprehensive evaluation of the slc transporter as drug target for treating metastases
metabolomics in precision childhood nutrition a way for precision nutrition

the high prevalence of childhood obesity in several parts of the world indicates a worrying future health scenario making preventiona high priority this prevention should focus on diet and physical activity regarding food the beginning of establishing eating habitsand preferences occurs in childhood being necessary that this prevention and treatment is individualized in this context precisionnutrition offers a new paradigm for health where the focus is to prevention and treatment strategies based on an individuals uniquecharacteristics metabolomics which is in the omics group transcriptomics genomics and proteomics is being considered animportant aspect in precision nutrition reflecting more realistically effect of food on health and disease therefore the aim of thisproject is to identify the metabolomic profile in children aged 36 years and through a longitudinal intervention if eating behaviourand physical inactivity modify the profile of metabolites that can lead to obesity the data for this proposal will be derived from amulticenter parallel randomized and controlled clinical trial that will be carried out with a cohort of children followed initially by oneyear of intervention with the intention of 10 years in total the intervention will be based on healthy eating and physical activitymetabolomics data anthropometric dietary socioeconomic behavioural metabolic biochemical and food environment variableswill be collected similar studies to this are not available in the literature and have the potential to increase knowledge aboutnutritional metabolomics especially in early childhood and serve as a database for other studies with this population this can reducechildhood obesity minimize nutritional and metabolic risks in childhood and reduce the economic environmental and social impactthis disease
in situ expandable ultrasoft and stretchable neural probe clusters

the central cns and peripheral pns nervous systems perform the fast information processing and transmission throughout the body injuries diseases and disorders in the cns and pns represent a major issue for personal health and society as they are associated with several common medical conditions such as neuropathic and chronic pain paralysis major depressions parkinsons disease and epilepsy to name a few many of these conditions cannot be treated with medication but must be resolved by directly intervening in the electrical signaling of the nervous system to access the relevant neural structures within the brain or nerves penetrating probes are necessary one major challenge which is hampering the use of neural interfaces for precision medical treatments is the huge mechanical mismatch between neural probes and nerve tissue which in combination with natural bodily motions causes scar tissue formation around the probes this issue is especially severe for pns interfaces due to excessive tissue motions around the probes there is a lack of technologies that allows for chronic highdensity interfacing i within peripheral nerves and ii of deep regions within the brain the objective of the expandneuro research program is to address the current limitations by developing i new inert ultrasoft 50 kpa stretchable conductor that can be laser processed to 3 m features ii a novel ultrasoft highresolution multielectrode probe technology iii chronically stable penetrating cortical probes and peripheral nerve interfaces based on the probe technology iv in situ expandable ultrasoft neural probe clusters that enable chronic highresolution interfacing of deep brain volumes the project will have major impact within the materials and microfabrication communities and farreaching future implications for treatments of neurological injuries diseases and disorders
automated online monitoring control to improve processes and decision making in cell and gene therapy manufacturing

problem cell and gene therapies cgt represent a breakthrough in the treatment of a wide range of conditions however limited global manufacturing capacity owing to a lack of scalability prevents cgt from becoming widely available to patients therapies are prepared individually at central facilities in a series of complex open manual steps variability is high and a uniform manufacturing process is lacking automated standardized qualitycontrolled and decentralized processes are urgently needed to scale out cgt manufacturing bring down costs and enable treatment for millions of patients true automation requires an understanding of what are known as critical process parameters cpps currently manufacturing of cell therapies is carried out over several days with limited access to knowledge of cpps often obtained through intrusive sampling methods innovation we aim to enable inline continuous monitoring of key cell culture parameters during therapy manufacturing to do this we will create a selfcontained instrument that connects miniaturized biosensor technologies to a novel bioreactor to allow automation of the entire cell therapy manufacturing process in a closed system the device will accommodate a disposable singleuse sampling unit that will ultimately be adaptable to any bioreactor our platform will carry out continuous automated and closed monitoring of a set of welldefined cpps as indicators of the overall state of the cell culture we will select and refine our parameters and establish optimal ranges as predictors of process outcomes and product quality based on prediction algorithms and digital twin analysis this will allow continuous process monitoring while greatly lowering costs and risks associated with manual sampling our first application will be in car t cell therapy production but the advantages of automation with continuous monitoring will be further applied to other cgt product that involves culturing of cells
biocatalytic fluorescence switchon polymerizations for signal amplification in ultrasensitive diagnostics and biosensing of malaria

malaria is one of the most catastrophic infectious diseases causing nearly 250 million deaths in 2021 according to who although malaria is curable delayed diagnosis is the leading cause of death in malaria patients the major obstacle in malaria diagnosis is clinical assessment by conventional methods which requires welltrained clinicians and expensive equipment moreover pointofcare diagnostic tests are not sensitive enough to accurately detect low levels of parasitemia thus there is an urgent need for a rapid accurate and highly sensitive malaria diagnostic method based on the detection of parasite biomarkers in the bloodstream and amplification of weak parasite signals by novel methodsin recent years atom transfer radical polymerization atrp a controlled radical polymerization has been studied as an attractive method for signal amplification in biosensing because the chain reaction accumulates monomers in the form of polymers at the site of polymerization in addition clinically relevant metalloproteins have been detected using this polymerbased signal amplification techniqueherein the aim of this work is to develop biocatalytic fluorescent switchon polymerizations with a triple signal amplification strategy for ultrasensitive diagnostics and biosensing of malaria the polymerizations will be used in assays for malaria diagnosis based on hemozoin metabolic byproduct of all plasmodium species and in immunoassays that involve antibodyperoxidase conjugates lateral flow immunoassay enzymelinked immunosorbent assay elisa and immunofluorescence staining for low abundance malaria antigens the diagnostic platform will be a collective combination and use of multiple independent technologies in a unique design to detect realistic and feasible malaria biomarkers found in peripheral blood
open force microscopy for biology and biomedicine

the emergence and establishment of mechanobiology has led to a growing demand for the mechanical characterization of biological samples moreover nanomechanical tests for diagnosis and prognosis of diseases are now being applied in clinical trials atomic force microscopy afm is likely the most versatile robust and standardized tool for nanomechanical tests of biological systems however commercial afm systems are expensive not dedicated to mechanical tests and difficult to use and customize to solve these problems we propose to develop and build an opensource force microscopy prototype openfmlab built on the instrumentation developed during erc consolidator project mechadyna the openfmlab system will be affordable customizable userfriendly and dedicated to mechanical tests in biology cost reduction will be assured by using opensource design hardware and software and a function exclusively dedicated to mechanical measurements the development of robust protocols and algorithms for calibration data acquisition and data processing will provide easeofuse finally the system will be modular and adaptable to any optical microscope and experimental setup during the openfmlab project we will design build implement and test the system inhouse and with external endusers at biology and biomedical laboratories and industrial partners we will explore cost reduction and create collaborations to add value to the system and define licensing and knowledge transfer and commercialization strategies the final goal of openfmlab is to make afm for nanomechanical testing a common tool in any laboratory
grid forming loads to provide maximum flexibility and enable future power systems with very high renewable generation penetration

modern power systems are experiencing a deep transformation motivated by the massive deployment of renewable energy generation the irruption of electrical mobility and the digitalization of the energy systems in traditional power systems power balancing is provided by conventional power plants that are capable of adjusting the power injection however the recent massive deployment of variable nondispatchable powerelectronics interfaced renewables mainly solar photovoltaics pv and wind power has brought a very important challenge and demands to rethink how the whole power system needs to be designed operated and protected solar pv and wind have limited flexibility compared to other technologies which store the prime resource the flexibility can be provided by operating these noncontrollable renewables below the point of maximum power generation with the associated loss of generation using energy storage or with demand management in addition to power balancing it is also required to provide grid services and forming the grid ensuring stability while this is traditionally provided from the generation side this project focuses on providing these functionalities from the loads thus developing the concept of grid forming gf loads and allowing renewable generators to operate at the point of maximum power availability the project objectives include the concept definition selection of loads development of controllers implementation in relevant applications electrical vehicle chargers pump drives railway power systems systems studies and technoeconomic and environmental studies on the impact the project is structured in seven work packages and includes experimental validation of the concept in selected loads and overall systems studies
biomarkers of the interplay between brain networks and cardiac dynamics for the evaluation of noninvasive braincomputer interfaces

braincomputer interfaces bci hold promise in the restoration of lost sensorimotor abilities after stroke a leading cause of disability yet their effectiveness varies because bci typically need to be customized for each patient for this the development of objective markers for monitoring task performance learning and progress remains one of the main challenges in bci we aim to develop biomarkers to assess the effectiveness and progress of bci interventions netcore focuses on biomarkers derived from brainheart interplay this approach has proven valuable as changes in brainheart interplay correlate with disrupted perceptual abilities and even severitymortality after brain damage notably analyzing brainheart interplay provides more insightful information compared to studying each organ separately our innovative methodology combines network science and biomedical signal processing to estimate interactions between these two systems in the context of motor imagery we will explore various approaches such as generative data methods multilayer networks higherorder dependencies and deducing potential causal interactions from physiologically informed neural models then brainheart interplay will be studied during bci training progression in healthy participants to later contrast with a subset of patients who suffered stroke traditionally braindamage research mainly focuses on the brain itself overlooking its multisystem impact our ultimate goal is to pave the way for future biomedical breakthroughs in the emerging field of brainheart interplay through these efforts netcore strives to enhance the potential of bci in aiding braininjured patients and showing the potential of studying brainheart interplay in healthcare and neuroscientific research netcores development will take place at the paris brain institute which provides an ideal interdisciplinary environment for this research in terms of expertise equipment and human resources
cultural heritage in rural remote areas for creative tourism and sustainability

the main objective of the project is to contribute to the promotion of cultural and creative tourism activities considering the different capacities resources and specificities material creative human of the territories as a mean to help with the sustainable development of peripheral rural areas favoring job creation and population settlement for this the potential of its cultural heritage will be researched taking into account both the artisan material culture techniques materials patterns and decorative elements as well as the intangible culture music oral knowledge and culinary traditions as a resource to promote nonseasonal tourism as a form of sustainable development with a stable population settlement we are going to research the crafts linked to the territory and their implications but we will also carry out a documentation of the productive processes first and foremost we are going to cater to the necessities of the local communities and pay attention to aspects related to societal groups at risk of exclusion such as women the elderly and the youthall this will be developed from a multidisciplinary perspective for which we will count on the various teams most of them linked to different countries that will be part of the consortium each of these partners will contribute to the development as well as to the final result of the project through input directly related to their area of expertise for example among the collaborators we have intellectual teams specialized in the digitalization of heritage research or communication and dissemination as well as as various institutions that will act as a testing ground for the more practical parts of the proposal however if something will characterize our work it will be the constant collaboration between all parties as well as the exchange of advice and experiences that will help to enrich collective knowledge and guarantee optimal results
realworld emission experiments and comprehensive assessment of lowcarbon fuels towards clean hardtoelectrify traffic modes

the realchem project aims to promote a clean and climatefriendly transport system by studying emissions from low carbon fuels in hardtoelectrify hte transport sectors including aviation shipping and heavyduty onroad and nonroad mobile machinery the project will observe emissions from various fuels and engines under reallife conditions model their effects on air quality and human health and focus on the most important new technologies realchem will use a large amount of preexisting data on both lowcarbon and fossil fuels and conduct novel experimental work in all three hte transport modes the aim is to produce guidance and technology packages for cleaner transport in terms of health effects and climate impacts the data will be organized into a lowcarbon fuel emission database which will help realchem generate new knowledge and identify the most efficient new fuels and technologies the project has three main objectives 1 produce robust comprehensive and actionable scientific data on the characteristics of emissions from lowcarbon fuels in the hardtoelectrify transport modes 2 understand the effect of introducing lowcarbon fuels to the developing technology matrix on human health climate and the environment 3 help technology developers and users to understand the emission formation and reduce the harmful pollution from engines using lowcarbon fuelsthese efforts are in line with europes ambitious climate targets the green deal and the vision of zero pollution by 2050 the need for combustionbased technologies in heavyduty transport nonroad machinery shipping and aviation sectors remains and the decarbonisation of these sectors is expected to be driven by a shift from fossil fuels to lowcarbon alternatives this will lead to changes in combustion technologies and air pollutant emissions realchem will provide scientific evidence and recommendations to navigate this changing future
deciphering the oxidizing capacity of the past atmosphere

atmospheric chemistry is an essential component of the functioning of the earths climate it determines the atmospheric lifetime of most climatic agents impacting the nature and concentrations of aerosols greenhouse gases cloud formations determining how this chemical reactivity has evolved in the past is essential both for evaluating chemistryclimate models ccm and for establishing future climate trajectories the chemical activity of the atmosphere is driven by highly reactive atmospheric compounds that have a very short lifetime in the atmosphere because of this ephemeral nature they are not archived in the paleoclimate record reconstructing this chemical activity over time remains a difficult exercise that has not been successful to date using ice cores the multidisciplinary docpast project proposes to develop new tracers of this chemical activity by taking advantage of the revolution introduced by clumps and isotopic anomalies the aim is to use a variety of ice cores covering all latitudes to highlight key elements of the chemical reactivity of the atmosphere this will be done by 1determining in the laboratory the isotopic characteristics of key oxidation reactions of atmospheric of compounds preserved in the ice 2documenting in the ice archives these isotopic compositions and deducing the associated chemical reactivity of the atmosphere 3incorporating in the ccm lmdzinca these changes and measuring their impacts on climate these new isotopic proxies will require the development of new analytical approaches based on the retargeting of an orbitrap towards isotopic measurements and the construction of a very high sensitivity infrared spectrometer paving the way for the use of clumped isotope in broad disciplinary fields using stable isotopes docpast will provide for the first time in situ chirurgicallevel of how atmospheric species are made with unparalleled mechanistic details and set new standards in geochemistry and spectroscopy