Dragon09/odtu_chatbot huggingface dataset:
deciphering the impact of bioelectrical communication on human neuromuscular organoid maturation

stem cells and organoids have revolutionized our ability to build tissues and organlike structures in a dish organoid models of a wide range of human tissues are increasingly applied to drug and treatment development and to fundamental and translational studies however the challenge of simultaneously growing more than one different tissues in a single functional organoid remains human neuromuscular organoids nmos represent a landmark discovery toward building more complex and physiologically relevant human tissues in vitro nmos closely capture the cellular repertoire and structural and functional properties of the neuromuscular system but similar to other organoids they do not reach adult tissue stages of maturation at least in part due to lack of connectivity and in vivolike sensory inputs including bioelectrical cues essential in physiological phenomena in a multidisciplinary approach the eneuromus project aims to test the hypothesis that delivery of brainlike input currently excluded from nmo models will enhance the complexity and maturation status of nmos toward adult tissue stages to this end nmos will be interfaced with conformable multielectrode arrays based on organic conducting polymers to expose nmos to brainlike input via electrical stimulation and to record nmo electrophysiological activity in a growth stagedependent manner to decipher the effects of electrical stimulation on tissue maturation electrophysiology assays will be combined with cuttingedge technologies including spatial transcriptomics optogenetics and advanced imaging this analysis pipeline will result in a rich dataset unravelling the longterm effects of electrical stimulation and the molecular pathways involved in the maturation of human neuromuscular organoids overall the eneuromus project will deliver a novel and sophisticated framework for engineering the next generation of biohybrid organoids as tools for modelling human development and disease
aibased wearable sensors for continuous monitoring of diabetes and cardiovascular diseases

cardiovascular diseases cvds are the leading cause of death in europe with a total of 39 million deaths yearly accounting for 45 of all deaths diabetes is another widely spread disease affecting 60 million people in the eu 10 of the total population diabetes is the major cause of death in the age of 2079 also europe has the highest number of children with type1 diabetes compared to other regions with approximately 140000 diagnosed children and it has one of the highest prevalence rates of diabetes in children with 21600 new cases per year frequent glucose monitoring is critical for keeping blood glucose levels within a specific range to prevent potential cardiometabolic disease progression and pathophysiological changes current standard healthcare systems are passive and reactive which deal with issues incidents and accidents after the opportunity to prevent damage to the patient has passed with reactive healthcare doctors provide treatment once patients contact them after developing noticeable symptoms actions are taken after things go wrong and sometimes after the opportunity to save the patient has passed besides economically reactive safety measures are costly in the long term moreover this routine fails to prevent the onset of health conditions by prioritizing diagnostics and treatment sensai aims to tackle the limitations of centralized and reactive healthcare systems by taking a proactive approach using tailored noninvasive and personalized solutions wearable monitoring devices specifically developed for diabetes and cvds without affecting peoples daily routines
nanopersonality engineering and manipulating green solvents by nanobubbles nimble

nanobubbles exhibit several unique physical and mechanical characteristics such as dramatically reduced buoyancy extremely high surface areavolume ratio large zeta potentials enhanced solubility of gas in water these properties render them good candidates for several commercial applications such as fineparticle flotation wastewater treatment and in food and agricultural industries a most important challenge lies in establishing facile and easilycontrolled methods to promote nanobubble formation and indeed liquidphase nanodroplets ie in realising reproducibly and consistently a nanophase nimble revolutionises formation of the nanophase providing substantial enhancement in effective gasliquid solubility in water and aqueous media further energy demands are very low visvis other nanobubblegenerating technologies with nanobubble stability over months a grand challenge lies in understanding underlying mechanistic phenomena involved in nanophase formation and the metastability of pure nanobubbles indeed developing experimental and theoretical insights into controlled ondemand release for nanobubbles is also vital for efficient processengineering applications in this erc nimble project stateoftheart computersimulation methods in molecular and larger continuum scale will be employed in tandem with advanced experimental setups and techniques to investigate and manipulate mechanisms of nanophase formation in the presence of electric fields workpackage 1 as well as its controlled ondemand release workpackage 4 with applications to carbon capture and agriculture using nanobubbles carrier personality nimble will employ stateoftheart experimental and simulation methods to investigate and manipulate nanophase formation in electric fields and controlled release and study their mobility and carrier agency with applications in carbon capture water treatment and agriculture
negotiating sovereignty challenges of secularism and nation building in central eastern europe since 1780

why does the modern state with its claim to sovereignty care so much about secularization and resacralization in order to address this question the project examines the prehistory of the conflictridden relationship between transnational institutions and the modern state and also the players who stood at the point of intersection of the two by analysing the shifts in relations between the state and one of the oldest transnational institutions in the world the catholic churchthe project examines the conflicts between church and state and the various processes involved in attempts to address these conflicts first and foremost by studying the history of the oaths of loyalty that the chief pastors of the catholic church were obliged to take and the tensions which arose because of these conflicts in the habsburg monarchy and its successor states between 1780 and 1990 oaths of loyalty to the state bear the marks of the changing relationships between the nation state and the transnational catholic church and were generated directly through the negotiations of sovereignty among these actors the project will offer a comprehensive interpretation of oaths of loyalty in the context of josephinism nation building and communism and their transformations in the context of the shifting relationships of the national state and transnational loyalties thus it will provide much needed tools for a longue dure and comparative analysis of statechurch relations in central eastern europe it will also discuss patterns of continuity and discontinuity between the church policy of different regimes the common and different features of the role of catholicism in nation building and the related change of function of the catholic hierarchy among the peoples of the habsburg monarchy on the plane of global history it will offer new insights into the roots and the prehistory of the conflicted relationship between transnational institutions and state sovereignty
enabling massive integration of pv into buildings and infrastructure

a dramatic rise in the implementation of renewable energy sources is needed if we want to meet european climate protection targets photovoltaic pv costs have decreased spectacularly over time turning photovoltaics into one of the most competitive sources of electricity in the eu an economically feasible and spacesaving approach to increase the capacity of renewable energy sources is to integrate pv systems into structures that already exist or to build new structures that originally integrate a pv functionbuildingintegrated and infrastructureintegrated pv are technologically proven solutions due to its multifunctionality buildingintegrated photovoltaic bipv installations can achieve a better economic and ecological balance over their lifetime than conventional building elements new technologies for pv cells electrical connections and front and back covers allow a free choice of formats and colours for integrated pv modules likewise infrastructureintegrated pv offers a large potential for pv integration due to the unique advantages of somewhat standardized constructions little emphasis on aesthetics and a small number of builders and owners compared to the building sectorhowever integrated pv ipv is still a niche market several barriers are still preventing the massive integration of pv into buildings and infrastructure the project massipv has been conceived as a multidisciplinary action that connects key players along the pv and construction value chains the goal of the project is to demonstrate that suitable tools technologies and methods combined with a collaboration framework among key stakeholders can overcome the barriers preventing the mass deployment of ipv and deliver multifunctional and costeffective ipv systems for buildings and infrastructure six different built objects will be used to demonstrate the technology representing different construction typologies in five different locations in europe
improving digital empowerment for active healthy living

the improving digital empowerment for active healthy living project ideahl aims at developing and testing new models and approaches of digital health literacy dhl intervention development and application through the cocreation of a comprehensive and inclusive eu dhl strategy the ideahl consortium is composed of 14 multidisciplinary partners from 10 eu member states which work hand in hand with patients citizens and the broad socioeconomic sector at local levelthe project will first conduct an extensive mapping of health literacy hl and dhl research initiatives and projects in the eu and beyond it will define best practices and champions in these fields to foster knowledge exchange and uptake of selected practices building on these foundations ideahl will launch a large cocreation process to design and plan its eu dhl strategy the project will involve over 1300 different stakeholders from citizens and patients to healthcare and social services policy makers nonhealth sectors academia etcthe collected feedbacks will allow to develop an inclusive strategy to improve dhl for the benefit of all citizens focusing on health promotion disease prevention treatment and selfcare as well as on monitoring its impact on the wellbeing productivity and the economy the strategy will pay special attention to social innovation inclusion gender and ethics privacy dimensions finally a number of actions of the strategy will be piloted in the 10 project countries from the testing and evaluation of the pilots ideahl will be able to put forward a common eu monitoring model and indicators for dhl levelsthe ultimate purpose of the project will be to empower eu citizens in using digital tools to take a more active role in the management of their own health and wellbeing as well as supporting social innovations for personcentred care models
restoring anisotropy in living tissues in situ

regenerative medicine aims to restore the composition and organisation of damaged tissues of the human body to regain tissue functionality when regenerating tissues inside the body in situ however restoration of tissue structural organisation is commonly overlooked this is particularly problematic for the heart where functional performance is inseparable from its structurally aligned anisotropic organisation at length scales from the cell to the organ two decades of cell gene and materialbased therapies to regenerate the damaged heart have mainly targeted the restoration of tissue composition so far with limited success i hypothesise that synergistic restoration of tissue anisotropy will radically improve therapy outcomes as it provides the proper environment for cell function will promote coordinated contraction and halt adverse effects like fibrosis and inflammation with my team i will test this hypothesis and explore an entirely new concept for restoring cardiac tissue anisotropy remotely using ultrasound we will create living model systems at the cell and tissue level that recapitulate the increasing heterogeneity of damaged cardiac tissue following cardiac infarction offer control of cardiac dynamics and allow manipulation of structural organisation to delineate the interplay between anisotropy and cell and tissue functions by integrating mechanistic understanding from cell and tissue level with multiscale computational modelling in comparison with an ex vivo living heart model we will rationally design strategies to mechanically realign diseased disorganised cardiac tissue at the organ level and evaluate to what extend this can be achieved using ultrasound by focusing on regenerating structurefunction properties in situ this multidisciplinary technologydriven project provides unique insights and novel tools that may open up new therapeutic concepts for regenerative medicine in general and cardiac regeneration in particular
democratize trustworthy and efficient large language model technology for europe

the trustllm project will develop european large language models llms on an unprecedented scale trained on the largest amount of text so far in european ai covering a range of underrepresented languages and pushing the limits of european exascale computing the main objective is the development of an open trustworthy and sustainable llm initially targeting the germanic languages this will create the foundation for an advanced open ecosystem for next generation modular and extensible european trustworthy sustainable and democratized large language models the trustllm project and the surrounding ecosystem will enable support and improve contextaware humanmachine interaction in a wide range of applications to achieve this trustllm will tackle the full range of challenges of llm development from ensuring sufficient quality and quantity of multilingual training data to sustainable efficiency and effectiveness of model training to enhancements and refinements for factual correctness transparency and trustworthiness to a suite of holistic evaluation benchmarks validating the multidimensional objectives the trustllm consortium has unique expertise and practical experience in building llms combined with leading nlp researchers as well as organizations working on transfering the technology to companies and endusers the models developed will be the most powerful and trustworthy llms in europe and they will constitute a major breakthrough in ai that will establish a new foundation for the next generation of largescale european ai models our focus on germanic languages can serve as a blueprint for future activities in other families of languages this will help secure europes sovereignty with respect to crucial ai technologies establishing a novel framework for european collaboration on llms and creating the foundation for a paneuropean center for llms and largescale ai to maximise the scientific social and economical impact
preclinical development of a nanomedicine candidate for fabry rare disease treatment to enter clinical phase

despite the development of new orphan medicines in recent years there are still limited treatment options available for rare diseases nano4rare team has developed a patent protected nanoencapsulation ket for the development of costeffective therapies for rare diseases based on biomolecules nano4rare team has successfully used this technology for the development of a new patent protected medicinal product candidate named nanogla for the treatment of fabry disease which is one of the most devasting lsd rare diseases nanogla has been designated on january 2021 as orphan drug by the european medicine agency ema and the european comission with the eu h2020 smart4fabry nanogla was brought to an advanced stage of preclinical development first glptoxicology in rats included under phoenix eu project 95311020212025 nanogla production will be scaledup and brought to gmp conditions as a first objective nano4rare project will use nanogla engineered batches produced in the frame of phoenix project to complete the preclinical phase and generate sufficient quality data on safety efficacy and quality in order to get approval by regulators to proceed with clinical phase as a second objective a new spinoff company will be created for the advancement of the nanogla towards the market and the commercialisation of the patent protected nanoencapsulation platform to generate new product candidates for rare disease treatments
reduce reuse rethink packaging towards novel fiberbased packaging and reuse schemes uptake

packaging waste accounts for 36 of solid waste in eu towns with plastics being the most widely used material in european food retail covering 37 of food sold recent research shows that important reductions can be achieved by focusing on six plastic applications that are projected to account for 86 of the total reduction achievable by 2040 with multilayermultimaterial packaging constituting the biggest untapped potential consumer awareness of packaging waste and their environmental and social externalities is driving change while major brands encounter difficulties in selfregulating as they lack innovative solutions immediately applicable for their most complex packaging retailers as key actors in the food value chain can choose to lead the transition by promoting a fundamental rethinking of their delivery chainsr3pack will contribute to reduce reuse rethink packaging by securing fast and extensive uptake of industrially relevant crosssectorial costeffective innovative technologies allowing immediate substitution of complex multilayer plastic packaging with high performing fiberbased packaging and economical industrial and environmental optimisation of reuse schemes demonstrated at large scale and transnationally in 3 eu countries by 2 major retailers covering the needs of 13 different food product types r3pack will moreover offer a clear pathway towards a normalized framework for reusable packagings food safety and for reusable packagings washing methods that will serve as reference at eu level r3pack will finally offer decision support tools ready to be used by businesses to choose the right packaging solution between optimized reuse schemes and developed r3pack paperbased packaging meeting closely the needs of their products
democratizing quantum computing with 3d scalable and customizable quantum processors

quantum computing is moving from a research field to an emerging industry but quantum computer integrators face a critical bottleneck quantum processing units qpus are exceedingly scarce if a team of innovators envisions a new type of quantum computer they have two main options they can either raise enormous capital and build their own qpus or rely on a university lab for support this situation reinforces the dominance of incumbent tech giants and stifles innovation when the field needs it the most we reduce the capital intensity of the field by bringing customizable scalable and affordable qpus to the market we achieve this by combining three proprietary technologies parameterized designs highyield fabrication and scalable 3d architecture we have demonstrated our ability to deliver fully packaged qpus in less than 30 days to our customers this project will advance our 3d architecture from prototype to product and offer our customers modular 1000 qubit qpus
trustworthy ai for improvement of stroke outcomes

trustroke proposes a novel trustworthy by design and privacypreserving aibased platform to assist clinicians patients and caregivers in the management of acute and chronic phases of ischemic stroke based on the integration of clinical and patientreported data outcomes and experience for a trustworthy assessment of disease progression and risks enabling more personalised and effective management of stroke as well as providing interhospital benchmarking and sharing best practices specifically trustroke will address to risks of i clinical severity at discharge ii clinical worsening leading to unplanned hospital readmissions iii poor mobility incomplete recovery and unfavourable clinical longterm outcomes iv stroke recurrenceto this purpose a federated learning infrastructure will enable multiple clinical sites to build several trustworthy ai based predictive models by leveraging stroke data without compromising privacy and implementing bestinclass security and privacy protocols fairified clinical data from leading european hospitals and outpatient monitored data from a remote homecare system will be used i to train and validate trustworthy ai models for stroke prediction ii to personalise patients assessment of cardiovascular risk factors treatment compliance and communication with healthcare professionals trustroke platform will be trustworthy by design since it will be compliant with the recognized guidelines for building fair resources and trustworthy ai systems including the need for transparency explainability robustness accountability accuracy and security of the learned ai models a series of user experience studies will be performed to increase the usability of the platform and improve the communication to the endusers a final proof of concept clinical study conducted by world class stroke centres will ensure the highest level of trustworthiness of trustroke
business angels and crowdinvestors for startups human capital

the project aims at developing both an advancement on the extant research on the role of human capital hc within two major actors of the entrepreneurial finance ecosystem business angels bas and crowdinvestors cis and an original set of competencies generated by a partnership of academic and nonacademic institutions direct objective of the project is building a competence network able to improve employability and career prospects both in and outside academia in the entrepreneurship and finance sector thanks to a fully international interdisciplinary and intersectoral mobility of eu researchers a total of 91 outgoing secondments and 91 incoming secondments of researchers will be committed from the partners involved in three countries the objective of the project is to design develop and maintain a eu dataset on different dimensions of bas and cis innovative hc characteristics and their impact on startup survival and success performancesresearch on the relationship between investors hc and the growth and performance of startups within the entrepreneurial finance ecosystem is still at a seminal level considering the the impact of digitization the study of competences related to green and sustainability investing and female entrepreneurship the project will help advancing these research streams going beyond traditional hc features and assessing their impact on startup survival subsequent financing channels and a comprehensive set of financial and nonfinancial performance indicators through its training and dissemination activitiesthe project is expected to generate a large scientific economic and societal impact the results will offer useful suggestions to market operators and policymakers for emphasizing the contribution of bas and cis towards digitization and green transition in the finance sector