Dragon09/odtu_chatbot huggingface dataset:
cyber security toolbox for connected medical devices

accelerated digitalisation in health sector brings opportunities for costeffective and efficient delivery of personalised care through medical devices including software connected to it networks and increasingly combined with novel technologies ai cloud computing blockchain or 5g networks and simultaneously europe is witnessing an increase in the complexity and sophistication of attacks threatening such critical infrastructure cylcomed addresses the overall ambitious goal of strengthening the cybersecurity of connected in vitro diagnostic and software as medical devices cmds ivds samd maintaining their performance and safety for patients and preserving or enhancing the confidentiality integrity and availability of private data they exchange or allow to be remotely accessed and focusing on humans operating the technology as the weakest link in the chain for security and privacy with training and awareness measures tailored to healthcare staff needs it does so by enabling adoption by all ecosystem stakeholders of technologically sovereign and trustworthy cybersecurity methodologies and toolboxes for connected medical devices and the environments in which they are managed and operate platforms complemented with fitforpurpose guidance covering identifed risks and gaps it will further deliver i risk assessment framework with risk benefit analyses schemes and ii toolbox addressing cybersecurity risks and gaps in connected medical devicesiii assessment and extension of baseline standards best practices and guidelines covering challenges for cmds including sw making them fit for purpose when used in conjunction with novel technologies iv demonstrations and case studies in relevant on premise hospital scenarios covid19 patients monitoring and remote telemonitoring scenarios improving the life of paediatric patients cylcomed has 9 partners from 7 eu member states and 1 associate partner from switzerland and a duration of 36 months
computational model predictive and adaptive control tools

model predictive control mpc is applied with success in industry for automating constrained multivariable dynamical systems in an optimized way however some crucial aspects of mpc design largely remain to be addressed to unleash the full potential of mpc in applications the efforts required to collect experimental data identify the prediction model and calibrate the controller must be reduced considerably the controller must selfadapt seamlessly to cope with unforeseen changes and not require excessively demanding computer hardware for deployment this project aims to address methodologically such aspects and establish a theoretical and algorithmic framework for designing the next generation of nonlinear adaptive embedded mpc systems from data firstly to reduce datacollection efforts significantly we will develop tools that enable the design of experiments based on novel activelearning approaches to nonlinear system identification coupled with robust mpc schemes to ensure safe data collection secondly to cut calibration efforts down drastically we will devise innovative preferencebased methods that can learn from calibrators assessments and automatically detect critical closedloop scenarios thirdly we will develop methods for seemingly adapting the prediction model at runtime to cope with uncertainties and model mismatches not seen during the design as well as methods for approximating the control law with different tradeoffs between the amount of required online computations and the obtained closedloop performance to demonstrate the potential industrial use of the methodologies and algorithms developed in the project we will formulate and solve laboratory benchmark problems on an experimental robotic platform a challenging system for datadriven control due to its highly nonlinear multiinputmultioutput and fastsampling dynamics
integrated needlefree injection and sensing using optomicrofluidics

needlebased injections have revolutionised healthcare by providing an efficient delivery method for medications such as vaccines however there are significant drawbacks associated with using needles on a societal environmental and technological level needle phobia and infection risks can significantly impact patient compliance and safety with medical treatments while millions of used needles contaminate the environment every day lastly the effectiveness of certain drugs increases when injected intradermally but targeting the dermis is challengingwith isens we want to revolutionise the experience of people who receive and perform frequent injections to this end we are developing and commercialising a portable and needlefree injector called boldjet our technological breakthrough is threefoldneedlefree injection breakthrough we introduce an innovative needlefree injection technology globally pioneering the use of thermocavitation microjets our system excels in the precise and consistent delivery of liquids into the skins superficial layers surpassing current stateoftheart methods smart sensing capability the boldjet device will incorporate cuttingedge sensing technology enabling it to assess the unique properties of the patients skin before each injection this breakthrough allows for semiautomatic calibration tailoring the injection parameters to the specific skin type and treatment area realtime monitoring and precision boldjet goes beyond conventional methods by offering realtime monitoring of injection depth and volume this feature guarantees that each dose is administered accurately and consistentlywith our triple technology platform we will offer a safer more effective and minimally invasive injections that do not contaminate our environment this patientfriendly technology will result in a positive effect on society allowing millions of people to receive better and more personalised healthcare
diagnostic her2dxguided treatment for patients with earlystage her2positive breast cancer

her2 breast cancer affects around 390000 women annually worldwide ie 3 patients every 4 minutes over the last decade polychemotherapy and her2targeted therapies have improved patients survival however the reality is that most patients are cured with less intense toxic and costly drugs up to now no diagnostic test existed to guide the optimal therapy for each patient the 27gene her2dx test trl8 is a novel minimally invasive diagnostic tool which provides unprecedented predictive information for therapy optimization in earlystage her2 disease the definitive project will prospectively validate her2dxs clinical effectiveness proving its ability to significantly i reduce toxicities ii improve quality of life and ii reduce direct and indirect costs while maintaining efficacy endpoints and survival outcomes in patients with early her2 breast cancerdefinitive will combine international experts in breast cancer from international reference hospitals comprehensive cancer networks regulatory hta and medical statistics experts smes policy makers patient associations living labs and medical society networks definitive consortium will conduct a pragmatic clinical trial across 44 centres in 7 european and associated countries to randomize 304 patients with stage ii to iiia her2 breast cancer in a 11 manner and to be treated with the result of the her2dx test to guide treatment vs without the result of the test treatment by physicians choice according to local guidelines the inclusion and exclusion criteria will be very broad to make sure that most patients can participate in the trial and the results could be generalized to the overall population treated in realworld settings beyond seeking the endorsement and implementation of her2dx diagnostic test by clinical guidelines and healthcare systems definitive will boost the incorporation of affordable noninvasive diagnostic tools in the field of genomics and precision oncologythis action is part of the cancer mission cluster of projects on diagnostics and treatment diagnostics
enhancing entrepreneurial ecosystems for education

entreprenedu brings together different innovation stakeholders and educational entities from 6 different european countries 3 lowmoderate innovative regions it bg el and 3 high innovative regions be de ie the project aims at creating a high replicable and scalable education model cd venture capital program for both businesses and educational systems via a series of 3 hackathons developed at regional level supporting developed concept and ideas to become concrete solution at the end of the project the program will be validated in the 3 educational entities that are part of the consortium more specifically entreprenedu aims at enhancing the proliferation of new business model and entrepreneurial skills directly involving 90 teams of youth age 18 to 30 years old in 3 different hackathons 30 teams per hackathons providing a highlyreplicable model to provide business know how for young europeans which will be validated in 3 educational institutions it gr bg supporting the 12 most viable and promising ideas and concepts from the early stages to the commercialization of their solutions through 5 concrete outcomes that should be reached by the end of the project please refer to section 13 validating the venture capital program educational model in 2 universities and 1 vet entity on 90 studentsthe entreprenedu unique and interdisciplinary methodology will enhance entrepreneurial knowhow and business skills and activities in less and moderate developed innovation regions thus reinforcing their acceleration capacity and enabling youth to scale their concept to fully concrete solutions with strong market potential subsequently enhancing the development and competitiveness of these regions
targeting rank receptor as a novel therapeutic strategy in triple negative breast cancer

breast cancer is the most common malignancy among females in the western world resulting in nearly half a million deaths annually mainly due to metastatic disease triple negative breast cancer tnbc accounts for almost 1520 of all breast cancers 300000 women diagnosed worldwide per year and is commonly diagnosed in women younger than age 40 tnbc remains a clinical challenge due to high rate of relapse a propensity to form visceral metastasis and limited targeted therapies thus there is an urgent need to identify novel targeted therapies for the treatment of the tnbc targetrank is based on the innovative idea of generating novel drugs targeting rank receptor instead of its ligand rankl for the treatment of tnbc as well as a new panel of antirank human antibodies for research and diagnostic purposes small molecule inhibitors generated during the project could plausibly be positioned as a novel targeted therapy for tnbc and antirank antibodies commercialized for research applications due to the lack of specific antibodies on the market the most important benefits of targetrank are based on the unmet need to improve the treatment of tnbc patients and the economic burden for public health systems generated by standard nonselected and ineffective cancer treatments in addition if drugs against rank prove to be efficient targetrank derived assets could also clinically benefit most of the patients suffering bone metastasis that are currently treated with bone resorption drugs denosumab and bisphosphonates although our products are aimed for breast cancer they may be therapeutically relevant for other tumors expressing rank as nonsmall cell lung cancer rank antibodies will allow to stratify patients that might benefit from rank blocking molecules improving the existing treatments for skeletalrelated events and reducing the main complications associated with lifealtering morbidity affecting several types of prevalent cancers
surface water information management swim

the swim surface water information management project assembles a geographically diverse and interdisciplinary consortium comprising of smes a research organisation and an enduser ngo from 3 european countries cyprus germany and spain and two international copernicus cooperation partners usa and colombia together we aim to develop and test at trl4 a copernicusbased surface water information management application that provides continuous reliable and accurate monitoring and reporting of various ecological parameters water quality algal blooms predict future conditions water quantity and water balance assess risks related to surface waters floods and droughts and translate this information into direct easytounderstand actionable recommendations via an artificial intelligence decision support system and an interactive userfriendly layout alerts data visualization layers and reports to be used by water management authorities and relevant stakeholders for surface water management and more reliable decisionmaking swim will contribute to uns sustainable development goal 6 ensure access to water and sanitation for all and other important european initiatives and directives like the water framework directive and surface waters ordinance swim will use surface water information from copernicus earth observations eo satellite data that is calibrated and enhanced using insitu measurements from our patented satellite based iot internet of things hardware platform called wamo water monitoring developed by the consortium the platform will combine three main aspects of water management for specific water basins a water quality module including identification tracking predictive analysis and reporting of water quality indicators a water balance module for assessing the hydrological balance of water bodies and lastly a natural disaster assessment module for identifying and mapping of areas at risk of floods and droughts
cocreating transformative pathways to biological and ecosystem ocean observations

the bioecoocean project proposes a foundational change in how we approach biological and ecosystem bioeco ocean observation to enhance scientific understanding improve management and ensure sustainable use and development of the ocean our multi inter and transdisciplinary approach emphasises cocreation with diverse stakeholders to develop a blueprint for integrated ocean science bios to support and encourage operational workflows adhering to fair data principles this innovative product promotes holistic thinking facilitates communication and strengthens the ocean observing value chain the project also includes a strong research component advancing data collection monitoring dataflows and models for bioeco essential ocean variables eovs we will operate in living labs cocreating with stakeholders generating new primary data and leveraging existing data and observing infrastructure globally key objectives include developing an inclusive cocreated blueprint advancing eov implementation assessing current practices and technological options delivering excellent research cocreating operational workflows and prioritising capacity building the project will increase the technology readiness levels trl of critical components of bioeco ocean observation systems and tools and in particular the trl of the integrated ocean observing system the project will prioritise capacity building and collaboration with global ocean observation initiatives eg goos and mbon as well as with the overall biodiversity monitoring community eg geo bon that seeks to develop a global framework for biodiversity monitoring in the framework of the convention on biological diversity cbd to ensure wide discussion and adoption of its coproduced standards overall this project will significantly impact and strengthen various sectors and stakeholders involved in ocean and biodiversity observation and management from local to national to global levels
interoperability of the power electronics dominated grid by openness

power electronic pe devices are a key enabler for integrating renewable energy into our power system however to achieve interoperability of pe devices barriers are present in technology but also in intellectual property and regulation to overcome these barriers interopen offers a unique doctoral training program for 10 researchers that integrates multisectorial knowledge gathering electrical engineering and legal researchers to achieve the common goal of the interoperable pedominated power system openness will be a pivotal factor across the different doctoral projects tackling fundamental aspects of modern pebased electrical systems such as control protection interoperability governance and intellectual property challenges in line with the un sustainable development goals and the eu green deal interopens research program is divided into three complementary parts 1 engineering components for swift interoperability 2 integration of a resilient and flexible power system and 3 enabling interoperability from a legal and regulatory viewpoint interopens training program puts a particular emphasis on maneuvering the complex and rapidly growing power systemelectronics sector with specific intersectoral trainings on eg change management in critical infrastructure how to give good recommendations or simplification approaches for an efficient description of complex contexts to other domains comprised of 8 academic partners and 13 industrial associated partners interopen offers a broad industry and transmission system operator expertise for doctoral trainings research and secondments compared to previous eu projects and doctoral training networks on the interoperable pedominated grid interopen is innovative by including two fundamental and new aspects 1 the interplay of technical and legal perspectives is considered and 2 openness principles are the heart of engineering and legal research as well as training
dynamics of water next to solidstate surfaces and polymers

despite numerous studies of liquid water its molecular structure has not yet been fully resolved and understanding of its specific properties remains limited recent experimental and theoretical studies have shown that interfacial water formed on surfaces of various synthetic materials tends to exhibit longrange order specifically water exhibits unique physicochemical properties next to the super hydrophilic nafion surface such as the exclusion of solutes and microspheres higher refractive index and viscosity absorption at 270 nm and charge separation susceptible to incident electromagnetic energy ordered layers of water molecules have been also found next to biomolecules like proteins or dna suggesting a dynamic interaction between matter and aqueous media based on hydrogen bonding or other electrostatic interactions simulation studies have also shown that water adjacent to graphene surfaces could build an extensive hydrogen bond network suggesting that water might be involved in the pp interactions between aromatic groups in the attic project the water layer built in the vicinity of various surfaces will be extensively investigated at a molecular level by employing dielectric thz and raman spectroscopic techniques the spectroscopic studies will be initially focused on nafion and other hydrophilic surfaces and subsequently the interactions of water with the aromatic groups of graphene will be explored the last part of the project includes spectroscopic studies next to orthogonally synthesized styrenebased polymers that bear different functionalization to explore how alterations in the electronic density of aromatic groups affect the water dynamics and the overall selfassembly state of polymers in water this project aims to bridge the gap between diverse experimental and theoretical works on unique water properties and to pave the way for the development of innovative waterbased technologies
flexible and improved bordercrossing experience for passengers and authorities

the flexicross project aims to increased security and reliability of eu border checks for people and goods while enhancing and improving the border management capabilities through the development deployment and validation of a toolkit of innovative borderchecking solutions in real operational environments addressing road rail and port borders the resulting flexibility and dynamicity of border check planning will offer novel capabilities such as dynamic deployment of checkpoints and support via mobile applications for border personnel while guaranteeing high level of security privacy of personal data and protection of peoples fundamental rights through the flexicross solutions the following functionalities will be delivered i antitrafficking and antismuggling protection via predictive risk assessment of vehicle and people ii enhanced border security through portable biometric based checks iii secure person verification through realtime multisource crossreferencing iv flexible fast and costeffective deployment of adhoc border check points bcp v secure private and traceable sensitive personal data exchange based on blockchain technology and vi increased safety and improved experience for borderpersonnel based on advanced human machine interfaces and enhanced situational awareness via augmented reality ar to achieve these ambitious goals the flexicross project engages key european border authorities and endusers police portrail operators etc and brings them together with leading sw and technology developers research organizations and innovative smes to codesign the requirements and the solutions and to validate the project outcomes this collaboration will drive the deployment of three stateoftheart borderchecking trial facilities to enable real life trials in diverse operational environments namely vehiclebased road border crossing railbased bordercrossing and port embarkationdisembarkation
nr2f6 blockade as adoptive immune cell therapy for metastatic melanoma

melanoma cases and deaths are expected to increase in the coming years representing a significant burden for the european economy and healthcare system metastatic melanoma mm is the most serious form of skin cancer and is characterised by uncontrolled metastatic spread of melanocytes to distant sites although standard treatments exist significant clinical challenges remain resulting in limited response and high mm recurrence rates as a result of these limited treatment options the quality of life of mm patients is dramatically compromised emerging immunotherapies such as adoptive cell therapy act are promising but have significant obstacles including long manufacturing times high costs and most critically rapid exhaustion of infused cells due to the tumour immune microenvironment timeresearch in gottfried baiers lab has identified a unique way to effectively stimulate the immune system with an act by inhibiting nr2f6 an intrinsic immune checkpoint of t lymphocytes this is done through our nr2f6 blockadebased adoptive immune cell therapy for metastatic melanoma nr2f6aim approach where t cells are engineered for enhanced immune fitness prior to infusion this greatly sensitises the patients immune system to currently available immune checkpoint inhibitor therapy ict this approach will permit us to deliver a combinatorial treatment that can overcome time immunosuppression providing curative potential against mm nr2f6aim will block nr2f6 by a nonviral timeboxed gene silencing through a synthetic small interfering rna sirna transfection method this method will allow us to overcome therapeutic manufacturing hurdles through a oneday inhospital preparation of the act nr2f6aim will verify and optimise the technology in relevant in vivo and ex vivo study models to validate the potential of this innovative act it will also develop and execute an ip strategy and a commercial feasibility analysis to enter the mm market