Dragon09/odtu_chatbot huggingface dataset:
a revolutionary cell programming platform based on the targeted nanodelivery of a transposon gene editing system

aim the nanoengine project aims to develop a firstinclass dnabased nonviral targeted in vivo cell programming technology that can be utilized for treating a broad range of diseases including cancer and genetic disorders in this project the consortium aims to assemble characterize and test the targeted nanoparticles explore smallscale synthesis conduct proof of concept studies and develop a preliminary business planunmet need currently the accessibility of cell therapies specifically cart cell therapy to the general patient population is limited by high costs complexity and safety concerns these limitations are caused by 1 ex vivo manufacturing processes of adoptive cell technologies 2 requirement of highly specialized clinical facilities and 3 the clinical toxicities and the need for preconditioning chemotherapy therefore there is a large unmet need for alternative approaches that makes adoptive cell therapy truly affordable scalable and widely accessible in an outpatient setting solution we will develop targeted nanoparticles that form cart cells in vivo by combining a proprietary t cell bindercoated longcirculatory lipid nanoparticle and a nonviral transposonbased gene editing system as such we will circumvent the aforementioned issues associated with traditional cell therapies with reduced cost complexity and associated clinical risks greatly increasing the accessibility of cell therapies to patients worldwideconsortium the consortium will leverage main applicant nanocells deep knowledge on nonviral gene transfer technologies uu provides critical expertise on nanomedicine protein and cell engineering kiuoxf has developed a revolutionary single particle analysis method which allows the consortium to obtain unique drug product characterization insights sintef adds crucial knowhow on bulk analysis of targeted nanoparticles and is closely involved in regulatory standards for nucleic acid therapeutics qsar uses machine learning to predict nanoparticle performance and minimize experimental work
engineering cellular selforganisation by controlling the immunomechanical interplay

both scar formation and restitutio ad integrum during bone regeneration rely on cellular selforganisation that involve cell contraction and fibronectincollagen formation this early stage of cellular selforganization is later followed by angiogenesis and mineralisation scarfree regeneration of physiological tissue homeostasis requires balanced downregulation of early inflammation however little is understood of the immunemechanical coupling involved we aim to lay the foundation for reducing patient suffering resulting from scarring by combining two distinct scientific worlds for which we have been a major driving force the distinct regulation of local inflammation and the mechanobiology during regeneration by combining both of our areas of expertise we aim to harvest the potential of the novel crossdisciplinary field immunomechanicsthis ambitious project concentrates first on identifing the different mechanical niches that immune cells experience early in successful healing and nonhealing second we will engineer synthetic niches to control fibroblasts and fibroblastimmune cell interactions to steer cell selforganisation and matrix formation in vitro third we plan to verify that these synthetic niches reprogram hematoma composition and can thus reduce later scarring in vivo the proposed experiments are challenging as they have never been done this way before but are feasible since they capitalise on our strengths in osteoimmunology and mechanobiology novel technologies will be combined in a unique way to engineer the immunemechanical cell niche to passivate activated immune cells and to reprogramme cell fate this will allow us to substantially advance the basic understanding of the interplay between immune cells and their mechanical niche during early regeneration by harnessing the mechanisms of the immunemechanics interplay we will lay the foundation for advancing immunemodulatory therapies to reduce harmful scarring
mixed augmented and extended reality media pipeline

maxr is a 30month ia that will define develop and demonstrate a complete pipeline of tools for making processing and delivering maximumquality xr content in real time the pipeline will be based on open apis open file and data transfer formats to encourage development and support the integration of new open source and proprietary tools maxr builds on recent research and advances in virtual production technologies to develop realtime processes to deliver better quality greater efficiency enhanced interactivity and novel content based on xr media datathe interdisciplinary consortium of eleven partners from five countries covers the chain from technology development and product innovation to creative experiment and demonstration and from xr media creation to delivery to the final consumer it is built around europes leading media technology developers together with creative organisations operating in arvrmr virtual production interactive games new media tv video and news multimedia and immersive performance
framework editing of macrocycles through catalytic olefin metathesis

bioactive macrocyclic compounds are valuable platforms in drug discovery more often than not natural products represent attractive leads the structures of which may be altered by chemical synthesis to enhance efficacy lower toxicity and superior physicochemical properties the proposed project aims to a practical and programmable strategy for precise skeletal editing of large ring structures by aligning catalytic ringopening metathesis site andor stereoselective modification of the linear intermediates and formation reformation of the macrocycle through catalytic ringclosing metathesis the advance will significantly enhance our ability to navigate hitherto unexplored chemical space needed for drugs discovery the proposed investigations are centered on epothilone c an important naturally occurring compound we will to demonstrate the versatility of our approach by precise framework editing of this anticancer agent in a systematic way the first phase will entail ztoe isomerization of the macrocyclic alkene an alteration that will significantly change the molecules threedimensional shape this will be followed by site specific insertion of a methylene or a hydroxy methylene at one or both sides of the acyclic allylic sites we will then reclose the ring similarly ring contraction will be implemented through deletion of one or two methylene groups finally ring expansion and ring contraction will be combined to achieve ring distortion
next generation internet discovery and search

since the inception of the internet applications and services using the internet have evolved significantly in addition the number of devices connected to the internet the creation of vast data lakes as well as distributed data cooperatives has made searching and discovering data and generally resources a difficult yet very important field of research development and innovationtoday it is even more important to be able to find represent and ultimately make sense of internet based data sources and resources without the need of relying on nontransparent organisations offering such services potentially violating privacy and trustthe vision of the ngi search project is to change the way we use and experience search discover data and resources in general on the internet and web this includes new user interfaces for searching and representing data eg voice and image based heterogeneous data sources eg iot semantic data multimedia social media as well as traditional websites new methodologies eg machine learning and natural language processing in generic context and specific use cases eg industry 40 health social media
establishing a laboratory of cultural heritage in central romania

how can a university from a widening country achieve rd excellence faster and better the elabchrom project provides a twofold answer to this challengeon the one hand the solution we propose is not just a contingent twinning between various research institutions but a longterm partnership in the form of a university consortium that covers all branches of academic life in this respect lucian blaga university of sibiu lbus co has chosen as partners for elabchrom the university of jyvaskyla p1 and the university of burgundy p2 ie two of the best universities within the forthem european university in which lbus was included in 2021on the other hand a viable solution is also to exploit the advantages of the regional ecosystem which in the case of lbus translates primarily through the status of cultural cityarea of sibiu this status corroborated with the higher degree of development of ssh research directions in the lbus determined the choice of the main field of elabchrom specifically our project aims to establish with the support of the universities from the forthem alliance a laboratory of cultural heritage within lbus which will lead to an increase in the capacity to achieve excellence in research at the level of the institution as well as to a closer connection between citizens and academiaaccording to elabchrom lbus will be able to bridge the gap that still separates it from other member states universities through a series of institutional reforms the establishment of the laboratory organized mobilities and training of researchers and administrative staff joint activities with p1 and p2 common conferences publications and applications as well as through an exploratory research project meant to explain sibius successful development by exploiting its cultural heritage as well as to produce a model of regional development that can be transferred to other areas of the widening countries
strain engineered spatial light modulators based on 2d semiconductors

the main goal of stenso is to explore a new concept of spatial light modulators based on strain engineering of twodimensional semiconducting materials spatial light modulators allow for the creation of twodimensional light patterns and have found many applications in photonics image projection holography aberrations correction laser surgery optical tweezers etc these devices typically consist of an array of pixels that individually control the phase or amplitude of light passing through it or reflecting off it in stenso i will exploit the large refractive index tunability of 2d semiconducting materials upon mechanical deformation studied in my erc stg 2dtopsense to fabricate a new concept of spatial light modulator device
selfmanaged sustainable highcapacity optical networks

the goal of the season project is to design and validate a sustainable transport network infrastructure able to support beyond 5g and new emerging services the season infrastructure will rely on the joint usage of multiband mb and space division multiplexing sdm spanning the access aggregation and metrolonghaul segments supporting the requirements for xhaul further integrating the packetoptical and computing layers and targeting costeffective capacity increase a critical objective of such architecture is to ensure energy efficiency season will rely on powerefficient digital signal processing dsp mboversdm optical switching pointtomultipoint transceivers allowing traffic aggregationrouter bypassing and converged packetoptical solutions reducing the number of oeo conversions such complex infrastructure requires rethinking the control and orchestration systems towards autonomous optical networks addressing not only the integration in overarching control systems of the radio access network ran access and transport segments but also adopting more agile devops methodologies season will leverage on cognitive networks powered by streaming telemetry realtime network measurements and artificial intelligencemachine learning aimlaided service management and orchestration for nearreal time network operation moving intelligence as close as possible to the data plane and devising a distributed system based on multiple communicating agents and datadriven closed control loops season will have a clear impact on the society in a context with increased needs of connectivity and higher capacity demand required for services such as vrarthe season consortium includes major european telecom operators telefonica tim major vendors adva infinera pg ericsson three consolidated smes accelleran wings and westaquila and four topreputed research centres and academia cnit cttc fraunhofer hhi and upc
multiscale imaging of cardiovascular pressure gradients a paradigm shift in hemodynamic risk prediction

regional quantification of cardiovascular pressure gradients is critical for diagnosis treatment planning and risk prediction of many cardiovascular diseases still for a large number of conditions noninvasive assessment is obstructed by inherent method limitations and a wide range of cardiovascular instances exist where regional pressure behaviour remains unexplored the multipress project main objective is to develop a novel imaging paradigm for noninvasive assessment of cardiovascular pressure gradients overcoming critical limitations of existing techniques through a unique multiscale approach doing so the multipress project seeks to for the first time extend noninvasive hemodynamic risk prediction into previously inaccessible cardiovascular domains advance our knowledge of complex hemodynamic behaviour and tackle remaining urgent clinical challenges across the heart aorta and brain using deep integration of advanced fullfield magnetic resonance imaging 4d flow mri superresolution networks and physicsinformed image processing a set of core developments will allow for unique comprehensive imagebased pressure gradient assessment across 1 spatial bigsmall vessels 2 temporal fastslow flows and 3 flow laminarturbulent scales with developments consistently validated in dedicated insilico invitro and invivo cohorts these developments will then be utilized on a set of core applications across 4 cardiovascular scales heartaortabrain addressing urgent clinical challenges and extending imagebased pressure gradient quantification through previously inaccessible domains based in a unique multidisciplinary setting at scandinavias largest university hospital successful delivery of multipress will represent a paradigm shift in clinical hemodynamic risk prediction and pave way for new scientific knowledge revitalizing risk stratification of complex cardiovascular disease across the heart aorta and brain
deploying ecosystemic solutions to improve soil health and uncovering subsoil functions in the critical zone

life on earth thrives on the foundation of healthy soils including topsoil and subsoil while extensive research has focused on the topsoil layer the subsoils remain largely unexplored by bringing together key experts and practitioners deephorizon aims to unlock knowledge of the subsoil in critical zone in order to deploy ecosystemic solutions to improve subsoil functions for soil health deephorizon goal is to develop tools that will enable practitioners land managers and policy makers to access subsoil properties subsoil functions soil health indicators and financial decision support tools to promote sustainable subsoil management through a multiactors approach from farmers to policy makers deephorizon will 1 collect and use existing data on subsoils 2 generate new knowledge through extensive subsoil sampling and experimental effort 40 core sites to measure biological physical and chemical properties of different subsoils with contrasted management and different soil type organicmineral land uses forest grassland cropland and seminatural areas and climate 3 use innovative processbased models to quantify actual and potential subsoil functioning and soil health indicators and 4 involve practitioners and stakeholders in the project through living labs and partner networks to cocreate test and deploy innovative solutions to improve subsoil functions over 100 test sites across europe by creating its own community of endusers and key stakeholders deephorizon will ultimately promote sustainable management practices policyincentives and guidelines at eu level for increasing carbon storage and ecosystem services in subsoils and disseminate and communicate materials to a better understanding of subsoil relevance to the general public by improving knowledge and consideration of subsoils in general deephorizon will enhance soil health and pave the way for a more sustainable and resilient environment in europe
geothermal synergy enhancing industrial energy efficiency through steam hightemperature heat pumps and heatpowered cooling systems with operational flexibility and public trust

the geosyn aim to validate a groundbreaking geothermal steam heat pump coupled with heatpowered refrigeration systems for industrial applications specifically for the cascading use of heat from deep or shallow rock formations the solution prioritises environmental sustainability utilising water as the working fluid in all subsystems and anticipates improvements in costefficiency for geothermal application developments the solution aims to facilitate the exploitation of geothermal energy sources in regions with or without significant hydrothermal reservoirs seamlessly integrated with the industrial context and demonstrating versatility for widespread adoptionthe expected outcome is a substantial increase in the deployment of geothermal resources for heat and cold generation offering reduced environmental impact and enhanced economic attractiveness compared to the use of fossil fuels or electricity from the grid the envisioned design is a flexible solution capable of delivering stable and costefficient energy tailored to the specific site and application the solution is planned to be integrated with other renewable sources to enhance power supply reliability and grid stabilitythe geosyn will act to increase the awareness of the civil society on geothermal energy and will engage with policy makers to include the deployment of geothermal in local regional and national policies in addition it will demonstrate the affordability of geothermal heating and cooling uses for productive processes with existing examples and demonstration of the benefits of using the geosyn technology in industry increasing trustthe geosyn consortium consists of 10 organisations from 5 european countries italy denmark france norway ukraine representing different levels of geothermal maturity and with extensive experience in the sector both from the technological and social sciences point of view
building resilient research ethics diagnostics and medicines regulatory capacity during routine and public health emergency periods

an effective and strong regulatory system for health technologies is critical especially during epidemics and pandemic situations the demand for rapid approval and application of a variety of health technologies including diagnostics and medicines during covid19 has reawakened the world to the urgent need to have resilient regulatory capacities that can respond in a timely manner with corresponding efficiency national medicines regulatory authorities and research ethics committees are duty bound to prepare and be ready to respond in any health emergency through edctp2funded projects namely smert proforma pavia and ascend substantial progress has been made on strengthening some procedures for clinical trial control and pharmacovigilance these projects have enabled tanzania to attain who maturity level 3 making it a role model in east africa despite of this health technologies regulation in tanzania has struggled to cope with emergencies as witnessed in the covid19 pandemics due to limited capacity in the area of research ethics therapeutics vaccines medical devices and other health technologies we now propose breedime to further build our capacity in the context of epidemic and pandemic preparedness breedime will enable tanzania to achieve rapid response clinical trial regulatory capacity for therapeutics vaccines and diagnostics capacity for postmarket evaluation and appraisal of health technologies establish research ethics framework for electronic health data and materials storage access and sharing within and outside the country and establish a southsouth learning centre in clinical trials regulatory and ethical review capacities these objectives will be achieved through engagement of stakeholders in academia civil society public and government to generate evidence to inform new regulatory guidelines this will strengthen health technologies regulation and will enable rapid access to health care and technology during emergency rwanda which recently established her food and drugs agency will become the first mentee under the breedime southsouth networking in ethics and medicines regulatory capacity building the impact of the outputs of this study will be ensuring safety of pre and post registration health technologies in tanzania and east africa at large
uncovering the mechanisms behind rapid motor adaptation in the brain using recurrent neural networks

animals and humans learn some motor skills very slowly for example it takes about a year for a baby to learn to walk in comparison motor adaptation can be very fast for example the first time someone walks on snow it might take them a little time to get used to the new conditions but not a whole year and adaptation depends on previous acquired skillset mastering tennis for instance increases how fast squash is learned but also some bad habits from tennis have to be unlearned and switching to squash for too long can hurt ones performance in tennis but how the brain learns different motor skills is still unknown the main reasons are 1 it is very hard to record single neural activity for the time it takes to learn a new skill and 2 bottomup methods from computational neuroscience are very precise for modelling neurons and synapses ie the connections between neurons but fall short when it comes to learning behaviourally relevant tasks in contrast methods from machine learning are becoming increasingly more powerfulmy innovative idea is that instead of focusing on skill acquisition which is slow i propose to focus on rapid adaptation where recordings during its whole duration is feasible i propose to use datadriven machine learning methods alongside newly acquired motor datasets to uncover where changes occur in the brain during motor adaptation which brain regions are involved which rules govern the changes and how different motor skills interact unravelling the fundamental mechanisms underpinning rapid motor adaptation will equip me with the knowledge necessary to engineer tools that accelerate motor adaptation particularly for medical applications 100 million people in the eu alone suffer from a disability including movement disorders i propose to leverage these tools to accelerate how quickly users can adapt to intracortical braincomputerinterfaces to improve quality of live and increase patient adoption rate