Dragon09/odtu_chatbot huggingface dataset:
data spaces for flexible production lines and supply chains for resilient manufacturing

manufacturing industries continuously face the challenge of delivering highquality products under high production rates while minimizing non valueadding activities the recent covid19 pandemic is causing manufacturers to rethink and reassess their global supply chains and the flexibility of their production sites resilience means the ability to withstand difficult situations while flexibility can be considered as the ability to accommodate changes without incurring significant extra costs production processes demanding high human skill such as forming processes requires readjustment of the process parameters of all production steps as a new product evolves the deficiencies can be attributed largely to the lack of efficient ways for trusted data sharing among the stakeholders without interoperability barriers there is a need to be able to determine when such changes lead to deterministicchaotic behavior with far reaching consequencesflex4res provides an open platform to support production networks reconfiguration for resilient manufacturing value chains flex4res will utilize platformbased manufacturing that builds on the stateoftheart gaiax and ids technologies for datasharing in the horizontal supply chain and the asset administration shell aas that is to implement intrafactory reconfiguration practices flex4res considers the digital twin of the valueadding network a key enabling technology to achieve reconfiguration processes in highly flexible production systems and networks the key element of technology linkage is represented by the selfdescriptions with linked standardized information models especially in terms of resilience the developed platform and specialized hardware aim to improve the existing industryestablished lean management approaches related to reconfiguration management through the digitalization of the production characterized as industry40 by allowing for the information sharing between value chain stakeholders
how mechanical and electrical stimuli affect bacteria filamentation a major cell stress response

antimicrobial resistance is on the rise and it is predicted to become the first cause of death by 2050 one of the characteristic bacteria phenotypes of antibiotic resistance and more generally of a stress response is filamentation which has been linked to survival strategies and virulence and is present in the most common form of bacteria in nature biofilms thus characterizing the filamentation phenotype opens the door to understanding the physiology and adaptation of bacterial cells under stress and during colonization processesfilamentation results from a coordination of growth and division which are driven by the assembly machinery of the fts system the min oscillatory system and the nuclear occlusion system in particular fts participates in the septum assembly a ringforming cell wall that will separate the daughter cells whereas the min oscillatory system restricts the assembly of the division machinery at specific locations to avoid nucleoid cleavage when bacteria grow regularly a single septum forms by the middle symmetric division to separate the nucleoids of daughter cells however when bacteria grow anomalously longer filamentation multiple nucleoids continue to segregate along the cell at regular intervals and several putative septa are created yet filamentous bacteria do not grow indefinitely and division events occur randomly in terms of their timing and the selected septum this raises the unexplored question of how size is regulated during filamentation processes in this context we hypothesize that the interplay between mechanical cues eg filament bending and changes in the bacteria membrane potential play a key role to regulate bacterial filamentation thus the main objective of this project is determining how mechanosensitive and electrical properties of the divisiongrowth machinery in e coli regulate its filamentation
unmasking the molecular mechanisms mediating the antiatherogenic effects of glp1ras

cardiovascular diseases cvd are highly prevalent in europe causing more than 39 million deaths yearly atherosclerosis a chronic inflammatory disease of the arterial wall is the main underlying cause of cvd available strategies to treat and prevent atherosclerosis remain suboptimal therefore better understanding of its regulatory mechanisms is required to design new approaches to treat this inflammatory disease recent cardiovascular outcome trials demonstrated that glp1r agonists glp1ra reduce the rates of major cardiovascular events this glp1ra effects are hypothesized to reflect modifications on atherosclerosis through antiinflammatory actions however the mechanisms linking glp1r activation to control of atherosclerosis and vascular inflammation as well as the cellstissues mediating these effects are far from understood the main aim of my proposal is to identify the mechanism by which glp1ra regulate atherosclerosis regression offering a unique and innovative opportunity to study the role of yet unexplored glp1r cell types vascular smooth muscle cells and neurons of the enteric and central nervous system mediating its effects the multidisciplinary perspective adopted combining my background in academic research with preclinical models the experience in biomedical research of the host supervisor and the clinictranslational perspective of the partner supervisor gives this atheroglp1 project with the strong potential to identify novel mechanisms that are expected to have immediate translational importance for targeted use of glp1ras in the clinic to treat atherosclerosis and cvd importantly this proposal will allow me to gain transferable competences and get trained in the latest in vivo and molecular techniques to assess vascular and systemic inflammation letting me to reach scientific maturity to stablish a similar facility at the host institution promoting my transition to become an independent researcher in the era
improving treatment of ischemic stroke using virtual thrombectomy

acute ischemic stroke ais is the leading cause of death and disability globally in 2017 112 million people suffered from a stroke in european union and it is expected to increase by 27 in 2047 the ais occurred due to insufficient blood supply to the brain from blockage of blood clots or thrombus restoration of the blood supply to the brain is the primary objective of medical treatment after the detection of ais this can be done using recently developed minimally invasive endovascular stroke treatment evt the introduction of evt to clinical trials in 2012 revolutionised stroke treatment but nearly 65 of patients face posttreatment complications and disabilities such complications show a huge void in improving the evt treatment using in silico and in vitro approachesthe current project vthrombectomy proposes a framework for mimicking the evt procedure using in silico approach the evt consists of three major components stent retriever blood clot and flexible blood vessel mimicking these components for numerical simulations and understanding the mechanical forces involved is the primary objective of this project in which patientbased images will be used to mimic the cerebral arterial network and mechanical properties of thrombus will be replicated using patientbased clot stressstrain data the development of a virtual thrombectomy procedure will take place by solving these components using a multiphysics approach in a coupled way the major limitations involved in the previous studies were the use of an ideal cerebral artery model with rigid walls and the absence of blood flow during evt vthrombectomy proposes to address these limitations by the inclusion of patientspecific flexible blood vessels with flowing blood parametric analysis of evt using in silico approach can dive deep into the treatment and improves our understanding of the mechanical forces involved which results in improved and efficient devices to retrieve the clot
atomic scale coherent manipulation of the electron spin in semiconductors

currently a great deal of experimental research is dedicated to implement qubits on a wide variety of physical systems in the last decade researchers have observed opticallyactive pointdefects in 2d materials which serve as single photon sources and present spindependent optical emission making them promising spinphoton interfaces in parallel new local probe techniques have been developed to detect magnetic resonance on single atomic spins and more recently to demonstrate controlled charging and positioning of pointcentres in 2d semiconductors onespin lies at the junction of these very active fields inspired by the opportunity that these recent findings bring i propose to coherently probe single electronic spins localized at pointcentres in 2d semiconductors and to engineer their atomic environment the ultimate goal of this proposal is the demonstration of long spin coherence times for quantum information applications to achieve this ambitious goal i will develop a novel approach based on a unique scanning tunnelling microscopy technique which allows for the engineering excitation and optical detection of single spin resonance this approach provides a solution to the current lack of tools capable of simultaneously recording the atomic and electronic structure of defects their optoelectronic response and the coherence properties of their spins using this tool it will be possible to not only determine the role of the environment on spin coherence but also to engineer it by deterministically moving localization centres over the surface creating tailored ensembles of localized spin states i will use 2d semiconductors which being chemically stable and all surface are systems which can naturally be addressed manipulated and engineered using local probe techniques onespin has the potential to open new opportunities in the fields of material science quantum information and semiconductorbased quantum technologies
how to minimize the ecological footprint for functional electronics

a growing desire for continuous data collection real time information and connectivity has resulted in increased demand for electronic functionalities that are fully integrated in everyday objects consumer electronics healthcare wearable electronics iot and smart packaging are examples of market segments that follow this trend printed circuit boards pcbs are the state of the art to create electronic functions however this technology creates an ever increasing strain on the environment because recycling andor dismantling of the pcb can hardly be done a radical sustainability improvement requires disruptive electronics manufacturing processes technologies and materials printed electronics are more environmentally friendly than the traditional pcb due to their additive character printing instead of etching the absence of chemical etching materials low energy demanding process conditions and possibility for recovery or reuse of substrates and metallic inks thereto in ecotron flexible organic printed electronics are advanced through a multidisciplinary approach involving biobased materials innovative print processes and device and module dismantling technologies furthermore recycling technologies and standards will be developed that are eventually integrated in a process design for a printed electronics recycling plant simultaneously the lifetime of printed electronics is improved for larger implementation of printed electronics into everyday products ecotron will create usecase demonstrators in existing stateoftheart electronics products in consumer electronics smart packaging healthcare and wearable electronics market segments to demonstrate the potential environmental enhancements
the most efficient space propulsion ever put in space

deficiencies in propulsion systemscompactness power costeffectiveness fuel efficiency scalability and adaptabilitycurtail the potential of small satellites in low earth orbit leo hindering mission diversity and longevity the imminent surge in the deployment of small satellite constellations to fulfill communication observation and scientific needs underscores the urgency of addressing these limitations ionxs ambition is to craft the most efficient propulsion system for orbital assets our patented ionic liquid electrospray technology with unmatched thrust isp and fuel efficiency enables the versatility of configuring thrusttoisp ratios inflight enduring life durations and vectoring boosts in orbit ionxs transition from technological demonstration to onorbit operation and subsequently market availability will revolutionize the space propulsion paradigm by fortifying satellite mission capabilities and reshaping the course of space exploration
enhanced xcrossdisciplinary communitydriven imaging technologies for earth and environmental material research

the excite network is revolutionizing earth and environmental material science research by consolidating a critical mass of 18 research facilities in 12 european and associated partner countries into a unified infrastructure and providing transnational access to advanced imaging technologies this enables scientists to decipher complex processes within earth materials at scales from nanometres to hundreds of centimetres gaining unparalleled insight into the chemical and physical processes that govern among others environmental toxicity and its impact on human health critical metal extraction for renewable energies and the utilisation of earth materials as longterm storage for climatealtering gases the consortium fosters knowledgesharing and talent attraction bolstering the problemsolving capacity of the european research area moreover excite is driving interdisciplinary collaboration and crossfertilisation across academic institutions scientific disciplines and industry propelling europe towards a sustainable future the initiative offers dedicated training programmes to a new generation of researchers within the european open science landscape paired with access to worldclass imaging facilities and expertise for problemsolving research and innovation excite is introducing innovative service developments such as artificial intelligence and leadingedge imaging experiments to increase the users problemsolving capacity in addition the consortium is implementing customised project valorisation strategies to maximize the impact of research outcomes in academia society and the economy citizen science projects allow the public to participate directly within the excite network contributing to solving eu challenges as such excite is paving the way towards a sustainable future driving scientific excellence and creating positive societal impact
affordable smart gan ic solutions as enabler of greener applications

all2gan will be the backbone for the european power electronics industry by offering an euborn smart gan integration toolbox the project will provide the base for applications with significantly increased material and energy efficiency thus meeting the global energy needs while keeping the co2 footprint to the minimum46 partners from 12 european countries will collaborate on 8 major objectives along the entire vertical value chain of power and rf electronics o1 push the limits of industrial gan devices and systemonchip approaches for 100v o2 leverage the full potential of innovative substrates for gan o3 achieve novel benchmark solutions for lateral gan devices and integrated circuits 650v o4 reach best technical and cost performance of rf gan on si with novel integration concepts o5 break the packaging limits by application driven integrated solutions of high performance gan products o6 advance the methods to evaluate and optimize reliability and robustness of gan components modules and systems for shortest timetomarket and maximum product availability at the end user o7 demonstrate highest affordable performance for greener power electronics and rf applicationso8 roadmapping for the future gan technology development and applications to support longterm exploitationbusiness cases and european leadership beyond all2ganthe collaboration in all2gan is based on a work package structure covering activities on novel power and rfgan technologies for various voltage classes latest packaging technologies research on reliability and demonstration in 11 use cases with ambitious goals and a clear vision all2gan will unleash the energy saving and material efficiency potential of gan semiconductors for a broad field of applications thus being in line with the major challenges outlined in the ecssria all2gan technology will directly contribute to energy saving and cuttingedge green technology innovation asevery watt counts
reconstructing the archaeology of mobile pastoralism bringing the site level into longterm pastoral narratives

camp investigates longterm pastoral dynamics in drylands by developing an innovative and reliable methodology to study archaeological pastoral sites pastoralism has been recently endorsed by the fao as a successful strategy to achieve food security by efficiently exploiting the inherent variability in natural resources modern pastoral systems represent the legacy of animal domestication processes that started before the beginning of the holocene however our understanding of ancient pastoralism is hampered by the lack of a proper methodology that can overcome the ephemeral evidence that characterize pastoral sites camp will pave the way through methodological innovation to a more thorough investigation of past adaptation to dryland environments highly controlled data on the anthropic markers for pastoral activities chemical multielement by portable xray fluorescence phytoliths organic residues and isotopes will be collected in pastoral ethnographic settlements and analyzed to create models that will then be used to interpret the archaeological evidence camp will advance research in a methods and theory in the archaeology of pastoralism b anthropic activity markers and the use of pxrf in archaeology and c adaptive strategies in drylands this project is a unique opportunity to strengthen the study of pastoralism by providing a widely applicable methodology that can augment our knowledge on past human adaptation to drylands and inform the design of sustainable and historicallygrounded development strategies for pastoral futures camp methodology will be potentially exportable to other archaeological sites independently of their chronology cultural or geographic context representing an invaluable advance to archaeological methods at large
unravelling the pathogenic cellcell circuits underlying the tissue memory of nonalcoholic fatty liver disease

with the obesity epidemic global prevalence of nonalcoholic fatty liver disease nafld is currently at 25 and rising nafld results from accumulation of excessive fat in the liver and covers a spectrum of disease states from simple steatosis fatty liver to severe nonalcoholic steatohepatitis nash nafld patients are also at increased risk of developing secondary pathologies including infections and paracetamolinduced liver damage although the mechanisms behind this remain unclear as no pharmacological treatment of nafld exists to date patients are typically instructed to lose weight as this can alleviate symptoms however with the recent proposal of tissue memory of inflammation including nafld it is unclear if weight loss alone is sufficient to restore liver homeostasis or if recovered nafld patients remain more susceptible to secondary inflammatory events recently the host labs have identified key cellcell circuits that control the functional specialization of liver resident macrophages in the steadystate and fatty liver these findings led me to hypothesize that nafld could lead to tissue memory by disrupting the interactions between resident liver cells and establish aberrant cellcell circuits that maintain a pathological state even after weight loss furthermore i postulate that this nafld memory could facilitate the relapse into nafld but also modulate susceptibility to secondary insults indeed my preliminary data indicates altered susceptibility to paracetamol overdose here i propose to use singlecell rna sequencing and epigenetics to investigate how cellcircuits in the liver are perturbed after nafld regression and identify the signals underlying these alterations this project will further our understanding on how liver circuits are distorted in disease and could provide therapeutic avenues to reset pathogenic liver circuits in patients currently suffering from nafld or those in the process of weight loss and recovery
the social life of dead bodies a new ethnographic approach to migrant deaths in and around the mediterranean sea

thousands of people have died in the attempt to migrate into europe through irregular channels in fact 2023 has seen the highest number of migrant deaths in the mediterranean since 2017 we only ever see very few of these bodies some die in the deserts of sudan and libya never to be found others get stuck inside shipwrecks at the bottom of the mediterranean sea even the dead bodies that end up on the shores of europe often remain unknown and thus socially obscure however in their local communities left behind the dead and missing continue to hold great social importancesolid presents an innovative theoretical and methodological approach to understanding the social life of deceased migrants by employing a research strategy that is ethnographic global and collaborative the aim is to promote the humanisation and social visibility of deceased migrants by creating a broader understanding of the human lives behind the tragic statistics of migrant deaths the solid research project introduces the analytical lens of social anatomy which refers to the configurations of social arrangements that emerge around missing or deceased migrants as various people and organisations employ practices of determination to identify understand andor keep indeterminate who has passed away and how by bringing together forensic social economic humanitarian political and criminological actors and perspectives on the same unidentified bodies of deceased migrants solid pursues an innovative analytical approach to the anthropology of death and specifically to dying in anonymity it highlights the social importance of missing and deceased migrants in their communities as well as in europe by tracing the social concerns left behind in somaliland morocco greece and spain through the innovative methodological approach generative collaborations this method captures the multiple configurations of knowledge and practices as different actors respond to the same dead bodies