Dragon09/odtu_chatbot huggingface dataset:
new generation of bioactive coating for intravenous catheters and implantable medical devices to prevent infections and thrombosis

catheters and implantable medical devices contacting with the bloodstream are sources of internal blood infections and thrombosis catheterrelated bloodstream infections are one of the major causes of patient morbidity and mortality in intensive care units both thrombosis and catheterrelated infections are leading to prolonged hospital stay increased risks of mortality and high costs for healthcare system currently there is no coating technology on the market that allows preventing these two complications at once we developed a new innovative coating technology that enables simultaneous prevention of thrombosis and internal bloodstream infections this coating is made of layerbylayer crosslinked nanogels that can be loaded with an antithrombotic andor antibiotic drug we found that layerbylayer assembly of these nanogels controls the amount of releasable bioactive agents from coatedsurfaces innovation of our technology is linked to the wider space of used nanoreservoirs that can entrap several bioactive molecules thus combining several biological activities in a single coating in addition these nanoreservoirs can be deposited as a coating on the surface of any biomaterial or medical device whether metallic biological or polymericwe have built a consortium that combines the key technical and business experience to bring our innovative coating product to market readiness cmdcoat a young sme counts with top researchers and specialists in the field of cardiovascular diseases biologists chemists and pharmacist fresci is a company specializing on the business strategy and innovation management together we aim to accelerate the technological development and validation of our coatix technology and bring to the market a new bioactive coating solution for implantable medical devices
trust in european democracies

political trust has long been regarded as an important element of regime support and factor of regime stability it is widely associated with a number of positive outcomes in representative democracies political trust drives citizens interest and engagement in politics increases voting turnout and makes lawabiding behavior more common political trust is frequently equated to diffuse regime support and thus linked to the effective functioning and stability of the political system the proposed research effort will monitor the structural longterm drivers of political trust but also emphasize the strategies which can be employed by diverse actors and agencies to strengthen accurate and informed judgments of agency trustworthiness the objective of this ambitious project is twofold first we aim to design and implement a complex research effort to collect comprehensive evidence on the judgments of trustworthiness in a range of european states second the project will develop a comprehensive and transparent toolbox of shortterm and longterm policy interventions including recommendations and methodologies for enhancing trust in political institutions boosting transparency and inclusiveness of representative systems in europe while there is a growing concern about the crisis of democracy and democratic backsliding this research effort will provide an innovative theoretical perspective on the sources of regime support and strategies for trust building in the public domain the project looks at the different drivers of positive high trust in democracy and negative high trust in autocracy the project will facilitate development of a new paradigm of political trust and trustbuilding and will inspire emergence of new insights on the multifacet origins of political trust and multifactor nature of trustworthiness the project has partners in austria czechia france germany greece italy poland romania slovakia slovenia sweden and ukraine
physiological and evolutionary responses of cyanobacteria in a sustainable mars exploration program

the worlds major space agencies share a goal of sending humans to mars within the next few decades a sustainable human presence there akin to todays presence in antarctica could generate paradigmshifting knowledge at an unprecedented pace one major challenge lies in providing the food oxygen and other necessary consumables these cannot be shipped from the earth over the long term they should instead be produced on site and for this nostocaceae cyanobacteria can be instrumental fed with materials available in the martian ground and atmosphere they could provide feedstock for a range of bioprocesses which in turn could produce a wide range of consumables however fundamental knowledge is lacking to turn this concept into practical solutions the physiology of cyanobacteria in the foreseen cultivation conditions is poorly understood these conditions combine low total pressures low partial pressures of dinitrogen interactions with a basaltic substrate from which nutrients are leached and high concentrations of chaotropic saltsin the proposed project i will enable a deep understanding of cyanobacterial physiology in these conditions for this i will employ a unique approach combining cultivation assays in unique hardware previously developed by my team adaptive laboratory evolution cuttingedge omics technologies the development of a mathematical model which can predict the productivity and efficiency of cyanobacterium cultivation from martian resources and the construction of a testbed for the experimental validation of this model i will use the generated knowledge and tools to design characterize and demonstrate the viability of bioprocesses which dramatically improve the odds that mars exploration is done in a sustainable way finally i will adapt the concepts developed for bioproduction on mars to open new avenues for sustainability on earth which i plan to follow up by applying for an erc proof of concept grant
climate tectonics interactions using big datainformed models

earth topography and its subsurface are the result of complex interactions between tectonics and climate sediments in the shallow subsurface contain vital resources including water and energy that are crucial for mankind they also provide temporary and longterm waste and energy storage at the same time active deformation and rapid climate change interact posing significant risk for natural hazards such as debris flow hillslope instabilities and active faulting the objective of the initiate doctoral network is 1 to fill key knowledge gaps how climate tectonics interactions on a wide range of spatial and temporal scales control distribution of sediments landscape stability and geohazards using bigdata informed models and 2 to improve urgently needed training in linking large data sets to deterministic forward models and machine learning the training of a pool of dcs provides an excellent capacity building for the next generation of geoscientists combined training in large data modelling and entrepreneurial skills will prepare the dcs to create their own startup business at the end of the project and or be employed in industry or academia
who needs virtue the early academy and the way to happiness

who needs virtue the early academy and the way to happiness wnv aims to show that the theories developed in the early academy the phase of the academy immediately following the death of plato are crucial for understanding the dynamics and interplay of the origin of the debate on virtue and happiness in the 4th century bcehow do we human beings attain happiness and to what extent if any does virtue contribute to happiness these questions lie at the heart of western ethics from as early as the 5th century bce in antiquity there were two major competing answers to the question of how happiness and virtue are related the first model advanced by plato suggests that virtue arete is a sufficient condition for human beings to secure happiness eudaimonia differently aristotle holds that virtue is not sufficient for someone to live a happy life for other nonmoral goods eg health wealth and friends are also required these two models are usually examined in terms of their similarities and differences yet what is missing from the picture is an account of the framework in which this debate originally emerged and the discussions that contributed to shaping these responses wnv seeks to fill this gap by advancing the hypothesis that coeval developments in ancient virtue ethics can be more effectively understood as the result of a dialectic with and in the backdrop of the discussions of virtue and happiness conducted by the first generation of platos students
women tech eu x ctd as

primary objectives are market mapping and scaling growth related to our business plan it is highly relevant to implement these in our strategic planning and development from an early stage to assess our market opportunity at a fast pace secondary objectives are preparing our business for expansion through insight into public procurement and employmentup until today we have gained information on the market situation for vr training in norway and characteristics that are important to take into consideration in our country however we are focusing on developing vrtraining on international standardized procedures confirming a great potential for our solution outside of the country in order to succeed we need to dedicate resources to execute an analysis of the international market in particular we need to conduct a competitor landscape analysis in the field this includes addressing suppliers of medical training in vr and suppliers of elearning for procedural training additionally we need to address which markets will be our primary objectives for future expansion these will be addressed by conducting a target market analysis and industry overview we thereafter need to get insight and knowledge on the purchase process for our primary objectives besides building the foundation for our employmentwomen techeu can help our business growth strategy both through mentorship and financing we would benefit from having a mentor with experience from working with business in a fastpaced growth environment furthermore we would benefit if the mentor had worked with medtech andor internationalization it would be valuable for us to have a mentor that could play an active role in helping us improve our starting point related to facing the demanding and timeconsuming purchase process included in this is having mentorship to help us evaluate and strengthen our foundation for building a highperformance team
interregional deeptech and photonics support network for manufacturing

in recent years the manufacturing sector has been one of the stable pillars of european economic growth and therefore prosperity photonics as one of the advanced technologies for industry identified by the european union is a relevant deep technology that plays a key role in supporting and innovating the manufacturing ecosystem on the european landscape several initiatives exist that facilitate cooperation on photonics ranging from the public private partnership photonics21 to european wide clusters like epic association and the digital innovation hub photonhub europe however they focus mainly on support for individual organisations and while there is also the s3 platform partnership on photonics there is no support available to coordinate interregional cooperation in deeptech with the focus on photonics for manufacturinggoal of the project is the establishment of an interregional deeptech innovation support network for manufacturing with the focus on photonics output will be a joint supraregional strategy with bestpractice measures for the use of deeptechphotonics to support european missions and company competitiveness this strategy will be codeveloped by relevant regional stakeholders from the government body research industry and makers communities and include tangible steps to use the complementarities and cooperation potential of the regions to ensure crossfertilisation
understanding the evolution of continuous genomes

an organisms phenotype depends on a multitude of genetic variants spread over a linear genome this is widely understood and yet in practice has hardly been incorporated into population genetic analysis recent developments in theory computation and sequencing technology now make it possible to obtain and analyse whole haploid genomes on a large scale this proposal is to develop and apply a theoretical analysis of genetic variation that is spread over continuous linear genomes theory and methods will be developed in close interaction with empirical data from artificial selection experiments and from an intensely studied hybrid zone in antirrhinum for both we have a known pedigree and phased wholegenome sequence population structure will be analysed by following blocks of genome through pedigrees and across twodimensional landscapes selection on discrete loci will be analysed by finding its effect on surrounding haplotypes by analysing how favoured alleles become disentangled from heterogeneous backgrounds and by seeing how haplotype blocks flow past selected clines the contribution of variants that are spread across the genome to gwa to selection response and to hybrid zones will be modelled and the overall effect of inherited fitness variance on haplotype structure will be determined this work will establish a new framework for population genomics that goes beyond the current focus on individual loci it will help bridge the distinct communities within genomics quantitative genetics and population genetics which currently tackle these problems largely in isolation the project will develop better tools for inferring selection and population structure from dna sequence data and more fundamentally will give us a deeper understanding of how the abundant variation that is carried on linear genomes is shaped by evolution
kabbalah philosophy and power in the 14th and 15th centuries iberian peninsula

in the two centuries leading up to the expulsion from the iberian peninsula jewish communities continuously grappled with internal discord and shifting relationships with christian rulers and muslim neighbours internally two significant intellectual divisions took shape one targeted the nature of knowledge setting philosophers against kabbalists the other revolved around the interpretation of jewish law split between advocates of symbolic exegesis and proponents of literalism additionally a parallel rift rooted in demographic factors between jews steeped in islamic traditionsemphasizing philosophical speculation and esoteric imageryand those from central european regionsprimarily invested in talmudic studies and pietistic spiritualityincreasingly overlapped those intellectual divides externally these same communities were wrestling with the rise of christian dominance and the waning of islamic culture all these tensions are embodied by the ban waqr family andalusian in origin they lived in various cities served the crown and authored works in different languages on varied subjects they reached their literary peak with joseph b abrahams massive yet littleexplored conciliatory treatise between philosophy and tradition this judoarabic work aimed both to address the pressing intellectual challenges and to mend the communal fabric kapp will unfold in two phases first a historical exploration of the ban waqr family examining their contributions to the landscapes they inhabited second an analysis of the philosophical depth and political ramifications of josephs magnum opus through this bifocal lens kapp seeks to redefine our understanding of the interplay between these conflicts illuminating the critical roles that philosophers kabbalists and scholars with divergent interpretations of jewish law played as social forces thereby rendering ageold debates about the intricate mosaic of medieval jewish life in new sharper contours
future data services and applications for airports and network

fastnet belongs to working area wa5 addressing topic wa51 fasttrack innovation and uptake for capacity on demand and dynamic airspace and focusing on future data services and applications for airport and networkfastnet proposes solutions that contribute to the evolution of atm aviation into an integrated digital ecosystem characterised by distributed data services this project aims at further enhancing the airports and network integration in tactical pretactical and strategic planning through the development of the following two solutionssolution 1 enhanced aopsnop tactical planning with the inclusion of an airporttoairports aop to aop collaborative planning process and the use of artificial intelligence the solution aims to extend the consolidated demand and capacity balancing dcb process amongst airports and nm in this context it will include an airporttoairports collaborative planning process prior to the airporttonetwork process for performance benefits of all connected airports and the network such as improved punctuality optimized use of ground and airspace capacity thus leading to higher network efficiencysolution 2 aopnop strategic and pretactical planning this solution aims to extend the timeframe of the aopnop integration focusing on the strategic from months in advance until d7 and pretactical d7
organizing skills development for smart specialization conference under the hungarian presidency

in todays dynamic industrial landscape the agility of workers to embrace change stands as a critical factor the competitive edge of industries heavily relies on the adeptness innovation and adaptability of their workforce identified skill gaps and mismatches between labor demand and supply pose direct hindrances to the creation of employment opportunities it is imperative that skill development aligns with the evolving socioeconomic dynamics education and training must be tailored to equip individuals with the requisite skills to navigate and excel in the field of greendigital technologiesthe hungarian presidency conference will address different aspects of skills development and the smart specialization concept through various program formats and networking activities involving eulevel and national policymakers researchers and training expertsthe conference will contribute to developing the conceptual framework of skills development for smart specialisation address differences between member states and provide evidence for better integration of skills development into s3 strategies
optical sorting of cholesteric liquid crystal droplets

interaction between light waves and chiral matter is a fundamental topic in optics and material sciences when the matter is chiral light can exert linear and angular momentum optical torque which has a differentiated sense depending on the handedness of the material and the helicity of the light in this project we propose to exploit the intrinsic chirality of cholesteric liquid crystals droplets on a microfluidic chamber to generate a differentiated rotation on different enantiomers of cholesteric liquid crystal it has been shown numerically that rotating disks on a fluid produce a sorting effect isolating the disks with different rotation senses in this project we propose to exploit the chirality in cholesteric liquid crystals to generate contactless enantioseparation of droplets with plane wavefront linearly polarised light ensuring a robust and scalable enantioseparation technique the project contemplates producing optical enantioseparation of polydisperse cholesteric liquid crystal droplets immersed in a microfluidic chamber the project focuses on developing multidisciplinary aspects of light and matter interaction specifically when there is a handedness both in light and matter and is expected to generate impact and enhance new concepts in multiple fields ranging from applied mathematics to chemistry the researcher of the proposed project is gregorio gonzlez phd candidate of the university of chile chile with experience in nonlinear dynamics induced by light interaction on liquid crystal layers the supervisor will be professor etienne brasselet in the singular optics group at the host institution the university of bordeaux france
biodiversity value in spatial policy and planning leveraging multilevel and transformative change

despite international and european policies in place to halt biodiversity loss the effect of multilevel and multisector direct and indirect drivers of change contribute to continuing negative trends the biovalue proposal was designed upon the fact that persistent land use and land cover changes have a major effect on biodiversity loss and on the assumption that a transformative change is needed on paradigms goals and values shaping current spatial dynamics by a mix of sectoral policies such transformative change is in line with the ipbes 2020 report and the eu biodiversity strategy 2030 calling for coresponsible engagement of all relevant actors in a wholeofsociety approach to biodiversity to address this call we will explore the transformative potential of spatial planning as the arena for action and the territorial expression of multilevel policies strategic to invert current trends of biodiversity loss the objective of biovalue is to safeguard and increase biodiversity by better articulating three instrumental perspectives spatial planning environmental assessment and economic and financing instruments individually and in combined action biovalue builds upon knowledge created by several eu projects including a conceptual framework on transformative change to be adapted for analysing the potential of instruments and their interactions in local casestudies transformative potential lies in a focussing on key steps of the mitigation hierarchy avoid minimize and offset b addressing indirect drivers ia by guiding the operationalisation of the renewed eu finance strategy within spatial planning to avoid significant harm and to ensure redesign of potentially harmful projects in the design phase and c by providing better articulated instruments for mainstreaming biodiversity concerns into other sectors across different levels of governance
regulation of epithelialcells renewal by basement membrane protein composition and stiffness during gut homeostasis

the intestinal epithelium forms a tight barrier against pathogens and toxins while simultaneously absorbing ions and nutrients it is the fastest selfrenewing tissue in the body as over 35 days a complete turnover of epithelial cells is achieved homeostasis is maintained by tight coordination between epithelial cell proliferation differentiation migration and extrusion epithelial cells adhere and migrate on the basement membrane a unique sheetlike extracellular matrix that separates epithelial cells from the underlying mesenchyme composed primarily of laminins and typeiv collagen the basement membrane provides structural support promotes cell adhesion and polarity and serves as a mechanical and biochemical signaling hub although great advances have been made in identifying morphogenetic regulators of epithelialcell renewal spatial regulators that limit proliferating cells to the crypt or guide cell migration towards the villus tip are still missing interestingly basement membrane protein composition varies across the cryptvillus axis which could also affect its stiffness however whether these variations play a role in regulating epithelial cell renewal has not been addressed the overarching hypothesis of regutbm is that basement membrane protein composition and or stiffness define specific zones that promote cell proliferation or cell death and provide cues for directional migration of epithelial cells in gut homeostasis using exvivo tissue cultures and invivo mouse models i will characterize the basement membrane protein composition and stiffness using 2d intestinal organoid cultures i will decouple the regulatory impact of tissue stiffness and protein identity on epithelial cell renewal and identify the molecular mechanism which facilitates bmepithelia crosstalk during gut homeostasis