Dragon09/odtu_chatbot huggingface dataset:
highlighting novel mechanisms swaying erythropoietin expression and regulation

cellular adaptation to oxygen deficiency hypoxia is a complex biological process germline mutations occurring in the hypoxia genes pathway provided major information to dissect the molecular mechanisms regulating this pathway the objective of hypoxia project is to elucidate the molecular and regulatory mechanisms governing erythropoietin epo gene expression a major actor of the hypoxia pathway the originality of hypoxia lies in identifying naturally occurring germline epo mutations in patients with hereditary erythrocytosis presenting excess red blood cells production recently the host laboratory and european collaborators have identified intriguing genetic variants located in noncoding sequences of epo in six families with erythrocytosis remarkably all families exhibited normal circulating epo levels suggesting gainoffunction potentials of the new epo epo is the hormone that regulates daily red blood cells production and its regulation greatly depends on the developmental stage cellular type and oxygen concentration given the complexity in epo regulation hypoxia aims at deciphering the expression and splicing mechanism of the newly identified epo i will use an innovative cellular disease model based on differentiating human induced pluripotent stem cells hipscs into different epoproducing cells neural crest cells and hepatocytes the wildtype edited and mutant cells will then be studied using next generation sequencing approaches rnaseq and atacseq besides its erythropoietic role studies have highlighted various pleiotropic effects of epo such as its protective role in ischemic injury and wound healing and regulation of metabolic homeostasis including genderspecific epo response thus hypoxia cellular model may lead to the development of new therapeutics or treatments for erythrocytosis anemia and other eporelated disorders the newly identified epo isoforms might render this cytokine a promising game changer in human health
new manufacturing approaches for hydrogen electrolysers to provide reliable aem technology based solutions while achieving quality circularity low lcoh high efficiency and scalability

heraqcles stands for new manufacturing approaches for hydrogen electrolysers to provide reliable aem technology based solutions while achieving quality circularity low lcoh high efficiency and scalability project heraqcles delivers an operational 25kw electrolyser stack including balanceofplant based on aem technology to validate both our novel designformanufacturing architecture and innovative components developed for automated production processesaem electrolysis offers a more attractive costperformance ratio compared to stateofart pem electrolysis because these is no need to utilise precious group metals in stack components like catalysts porous transport layers and bipolar plates for generating hydrogen at reasonably high current density current stack manufacturing processes face bottlenecks limited by many separate components manual assembly and lack of tooling due to low production numbers the project focusses on increasing manufacturing readiness level from 4 to 5 by collectively advancing all components to comply with automated manufacturing processes at industrial scale forming of metal plates 3dscreen printing porous layers pilotscale synthesis of membrane polymers and catalyst validation occurs in three yearly loops using single cell short stack and full 25kw stack configurations where test results are benchmarked against commercially available options to highlight critical improvements of composition functionality and recyclabilitythe experienced consortium brings together a unique combination of knowhows acquired in previous projects eg anione and manufacturing capabilities provided by strong representation from industrial partners 6 out of 8 if successful the final qualified stack prototype can be scaledup quicklyfinally a business plan is established comprising of a technology roadmap an analysis of premium applications an overview of productmarket combinations and feasible market development plans
evolution of galaxies in largescale structures

i propose the project elate evolution of galaxies in largescale structures to be carried out at the kapteyn astronomical institute university of groningen rug groningen the netherlands under the mentorship of prof reynier f peletier elate aims to significantly enhance our understanding of the role of the environment in shaping galaxies by exploring all regions in the largescale structure the main scientific goals are to i robustly define the true location of galaxies in the fornaxeridanus complex ii identify the processes responsible for their morphological transformation in the lss iii provide a comprehensive view of the growth of this supercluster which will serve as a precursor for future studies concerning the evolution of galaxies in the cosmic web the workflow of this project is a combination of computer science observational astrophysics and cosmological simulations thereby bridging the gap between these fields to maximise scientific output the objectives will be addressed by i employing novel tools to define filaments of the fornaxeridanus complex from the 2mass redshift survey and study their structure and overall galactic properties in 3d ii detect lowsurface brightness features in the outskirts of galaxies from the dark energy survey multiband deep images using recently developed tools and thereafter map the assembly history of galaxies in the fornax supercluster my supervisor prof peletier at the kapteyn institute is an expert in studying galaxy evolution and interdisciplinary techniques and will guarantee the success of this project with his strong network in groningen and europe given my expertise in deep photometry and technical skills to execute this project and along with the prospective training that this mscaef will bring i will be competent to lead future research groups of my own paving the way for groundbreaking scientific results with upcoming surveys eg euclid rubin lsst
improvising europe jazz cultural globalisation and the reinvention of multiethnic identities

the research project focuses on issues of musical socialisation cultural assimilation financial strategies and gender inequalities within the jazz scenes of three major european cities barcelona budapest and manchester these three cities are illustrative of fundamental changes in the way that contemporary music scenes in europe are responding to challenges of globalisation and cultural assimilation this is most apparent in the many hybrid musical forms being developed by europes traditional gypsies and current immigrant diasporas quintessential others to express cultural identities given that each selected scenes functioning is closely linked to peculiar ethnic and racial characteristics the three scenes provide compelling examples of the way in which jazzrelated cultural practices reflect shape and reinvent europes cultural landscape this interdisciplinary research project of transnational comparative scope is expected to generate new knowledge on the contemporary musical expressions of cultural diversity and assimilation strategies through music in europe which is essential to design projects that enhance intercultural dialogue the following questions will guide the project how do musicians construct the trajectory of their musical distastes and how it relates to their socioeconomic status how does improvised music function to achieve cultural assimilation and at the same time to maintain distinctions linked to ethnicity race and gender how does gender become a relevant factor in acquiring prestige what types of economic and artistic strategies do musicians develop to achieve artistic autonomy throughout the fellowship the er will conduct 35 indepth interviews with mixedbackground jazz musicians undertake ethnographic fieldwork at eight venues submit two articles present at five conferences organize academic workshops and design an international series of popular science events to further disseminate the results
microfluidic diffusionbased chiral resolution

chirality is an essential property of nature producing and regulating fundamental phenomena in living matter chiral compounds are widely used in medicine clinical pathological and other fields different enantiomers of chiral molecules have significant differences in pharmacological activities metabolic effects toxicity and even opposite effects since most chiral compounds exist in the racemic form it is important to develop strategies for rapid and efficient separation and purification of chiral compounds to deal with inevitable future threats such as diseases and viruses although many techniques for chiral resolutions have been developed over the years most of them are impeded by low efficiency and accuracy high energy consumption tedious preparation and operation and high cost therefore i propose a project crms chiral resolution using microfluidics and helical supramolecular polymers which aims to develop a simple diffusionbased strategy for chiral resolution by incorporating helical supramolecular polymers hsps in this project i will combine the ability of hsps to recognize the handedness of chiral molecules through noncovalent interactions with the diffusionbased separation ability of microfluidics for the enantioseparation of chiral molecules i chose microfluidics for chiral resolution because it is a costeffective and energyefficient technique that takes advantage of the natural flow properties of the fluids entering the flow reactor for diffusionbased separation crms project will not only start a new area of research in the junction of supramolecular chirality and flow chemistry but also have applications in pharmaceutical and cosmetic industries for enantioseparation of chiral drugsingredients
microfluidicsassisted synthesis of dapagliflozinloaded liposomes for heart fibrosis development of a 3d bioprinted multicellular in vitro model

cardiovascular diseases cvds are the leading cause of death worldwide with half of cvds deaths being caused by coronary artery disease myocardial infarction is the most common cause of cardiac insufficiency leading to fibrosis and ultimately heart failure since current therapies for cardiac fibrosis have limitations there is a need for more effective strategies gliflozins eg dapagliflozin and empagliflozin hypoglycemic agents and sglt2 inhibitors usually used for the treatment of type 2 diabetes have been shown in recent clinical trials ie dapahf deliver emperorreduced emperorpreserved to reduce the combined risk of cardiovascular death or hospitalization for heart failure in patients with reduced and preserved ejection fraction regardless of diabetes status they have also been shown to ameliorate myocardial fibrosis postischemia nevertheless most of the underlying mechanisms of these benefits remain elusive and the potential adverse effects of the systemic administration of gliflozins must be recognised in this regard the use of liposomes as in situ injectable drug delivery systems offers many potential advantages for the therapy of myocardial infarction therefore the savetheheart project aims to develop a new therapeutic approach for the efficient treatment of cardiac fibrosis by using liposomes produced by microfluidics to encapsulate dapagliflozin dapa their effect will be studied in a 3d model of cardiac fibrosis that will be obtained by bioprinting a biomimetic type i collagen hydrogel bioengineered with human induced pluripotent stem cellsderived cardiomyocytes myofibroblasts and endothelial cells and cultured under perfusion and hypoxic conditions to better mimic a fibrotic response understanding cell behaviour in the proposed setting this work opens perspective to the optimization of injectable dapaliposome formulations intended as an innovative therapeutic strategy for the treatment of cardiac fibrosis
building knowledge and tools to advance on promoting of freshwater urban ecosystems as nature basedsolution for health and wellbeing in a changing word

cities around the world are undergoing significant transformations and are facing substantial challenges in the form of urban of climate change and ongoing urbanisation the idea that we can work with nature to improve our cities is now seen as vital the concept of naturebased solutions has emerged to foster sustainable development by transversally addressing social economic and environmental urban challenges although the attention to naturebased solutions inclusion is an important pillar of urban sustainability a clear understanding how they can be implemented in the freshwater landscape is still missing even in face of the relevance of the urban freshwaters to wellbeing of the population this investigation aims to fill this gap by analysing the social and environmental impacts of urban streams as important naturebased solutions from protecting water quality to reducing natural hazards while preserving biodiversity and providing health and wellbeing benefits to population by selecting as case studies aveiro and coimbra the research project aims to promote the urban streams and their multiple ecosystem services as important naturebased solutions to mitigate the effects of urbanization and climate change on aquatic ecosystems in the human health and in the wellbeing of the population the project will adopt the research strategies to assess how urban development affect a capacity of urban streams to provide ecosystem services using wellestablished scientific methods and investigate how the degradation of urban streams reflects on the local residents perception of the ecosystem services in terms of benefits health and wellbeing in addition thematic maps of ecosystem services identified in the urban streams will be produced to demonstrate the relevance of urban streams for ecological cultural and social aspects and to demonstrate can this information can be useful to urban planning and governance
tracing the evolution of sensory cell types in animal diversity multidisciplinary training in 3d cellular reconstruction multimodal data analysis and science outreach

all animals need to sense their environments the ability to detect light temperature chemicals sound vibrations and other stimuli depends on an extraordinary range of sensory cell types the diversity and relationships between these receptor cells across the animal phyla the ways in which they have been adapted reused tweaked and sometimes lost is little known but is crucial for understanding how animals survive and thrive in diverse environments most sensory cells are characterised by complex shapes and molecular machinery first discovered by meticulous electron microscopy in the past decades more recently this has been complemented by genetic studies of their development and differentiation in various animal models these two research programmes have however largely remained separate and a unified morphological and molecular understanding of how the diversity of animal sensory cells has evolved is lacking our aim in zoocell is to create a comprehensive view of sensory cell type evolution based on the discovery of recurrent patterns of genetic and subcellular structure across a wide range of new animal models to this end we will combine singlecell genomics correlative light and electron microscopy artificial intelligence and reverse genetics approaches in these species zoocell will bring together europes worldleading expertise in these disciplines and thus contribute to building the field of comparative integrative cell biology in animals while training the next generation of doctoral students in these novel interdisciplinary techniques we will develop new tools for combined molecular and morphological comparative analyses of cell types our interdisciplinary intersectoral and international training programme will also include dissemination and public outreach and the comprehensive training provided will enable our graduate students to assume leadership roles in academia industry and science outreach
isolating manyparticle correlations in time and space

electronic excitations are crucial in many fields of science and engineering timeresolved spectroscopy is widely used to detect dynamics of excited particles electrons and quasiparticles eg excitons or plasmons in the scheme of femtochemistry established since decades one excitation is placed into the system by a pump pulse and its evolution observed by a timedelayed probe pulse however this does not resolve correlations between multiple excitations making it impossible to understand important quantum phenomenawe shall develop and apply new experimental methods to determine multiparticle correlations based on isolating higher than fourth orders of perturbation theory systematically we will separate these contributions without requiring apriori models with tailored femtosecond laser pulse sequences we circumvent the stochastic nature of lightmatter interaction even though we use only classical light and retrieve information from specific orders of a perturbative expansion hitherto only accessible theoreticallywe also consider that many materials are heterogeneous thus we isolate multiparticle correlations in space by combining high nonlinear orders with fluorescence microscopy and photoemission electron microscopy this enables us to avoid ensemble averaging and obtain information for specific domains down to the singlemolecule limitour methods will be applied to determine exciton diffusion in organic materials chiral excitonic couplings plexcitonplexciton interactions quantum coherence in multiexciton generation phononphonon couplings in quantum dots and the role of dark states in correlated materialswe expect impacts to change how complex systems are studied with ultrafast spectroscopy overcoming limitations of singleparticle models we seek a holistic picture of correlated dynamics impacting our understanding and application of solar energy conversion transport in functional materials and quantum technologies
quantumenhanced machine learning

equal1 leverages commercially available semiconductor technology to deliver quantumenhanced machine learning solutions that empower businesses to overcome dataintensive ai challenges today we design quantum processor chips qpus based on silicon qubit technology and integrate them into a cryogenic system running at 270 degrees c our first serversized prototype alice has already demonstrated massive acceleration for ai applications through this project we will finalize the next generation version of our qpu codenamed bluefin number of physical qubits scaled to 64k in a quantum neural network array and integrate it within our workstationsized mvp demonstrator aquaris with its much smaller carbon footprint our scalable costeffective technology provides a path that will impact the trajectory of ai by making it more sustainable we will enable our customers to continue to leverage the power of ai to develop useful realworld solutions
interplay of blending and interfacial zones in sustainable recycled asphalt materials a comprehensive mechanical characterization and modeling study

the interplay of blending and interfacial zones in sustainable recycled asphalt materials a comprehensive mechanical characterization and modeling study bizsramcs aims to equip a promising young researcher dr yi li with advanced skills in interdisciplinary research this project endeavors to advance the sustainability of recycled asphalt materials rams by enabling precise durability predictions through comprehensive microstructural and mechanical characterization of the blending zone bz and interfacial transition zone itz the main research objectives include 1 a profound understanding of rams microstructure 2 enhanced lab assessment and modeling approaches for the mechanical behavior of bz and itz and 3 the development of an accurate numerical tool for predicting the response and cracking behaviors of rams this work carried out in collaboration with tu delft rwth and totalenergies is poised to strengthen the eus scientific and industrial leadership in ram innovation moreover bizsramcs will provide dr yi li with a broad spectrum of learning opportunities including project management intellectual property rights and teaching and supervising under the mentorship of dr liu an experienced scientist at tu delft the fellow will gain diverse knowledge and skills setting the stage for a successful career as an independent researcher in sustainable infrastructure
microbiotat cell interactions antigenspecificity and regulation in health and disease

the microbiota has an enormous influence on human health cd4 t cells play a central role in controlling the interaction with the microbiota by specifically reacting against individual microbial species t cells enable a mutualistic coexistence with microbes inappropriate t cell responses against microbes are in turn associated with inflammatory diseases thus the combination of t cell specificity and functionality form the key determinant for physiological versus pathological hostmicrobiota interactions so far research on t cellmicrobiota interaction is almost exclusively focussed on functional t cell subsets whereas antigenspecificity is rarely addressed this is a significant roadblock for developing targeted therapeutic interventions for microbiotaassociated diseasesthe interaction with the microbiota poses two particular challenges for adaptive immunity first the extremely high diversity of microbial species and thus potential t cell targets second microbes are persistent and thus probably encountered chronically currently we do not know 1 which microbes are targets of specific t cell reactivity in humans 2 how the chronic interaction with the huge number of different microbial species is regulated by t cell specificity and function and 3 how alterations of these parameters contribute to microbiotaassociated diseasesi developed a highly sensitive technology to detect and deeply characterize microbespecific t cells directly from human samples microt will identify microbial target species of human t cells and unravel the molecular mechanisms regulating chronic interaction of t cells with the highly diverse microbiota i will define the impact of specific t cellmicrobiota interactions on chronic inflammatory diseases and upon ageing answering these fundamental questions of microbiotat cell interaction will identify specific immune or microbial targets as an essential basis for rational development of novel targeted therapies