Dragon09/odtu_chatbot huggingface dataset:
how salty was the mediterranean outflow water

heat and salt are major components of the thermohaline circulation of the global conveyor belt as they regulate the masses of water bodies and and hence oceanclimate dynamics the thermohaline circulation thc has played a significant role in the past climate extremes such as the onset of the northern hemisphere glaciation although the temperature component of the thc can be extracted applying various methods such as foraminiferal magnesiumcalcium thermometry and alkenone thermometry salinity information of past seawaters is still among the unknowns in paleoclimate studies due to the lack of a direct paleosalinity proxy thus the role of one important salt contributor the mediterranean outflow water to the deeper levels of the thc during major climate shifts in the geological record is scarcely documented to that extent this research proposal aims at establishing and exploring a new proxy that will allow to extract information on past salinity changes in seawater from deepsea benthic foraminifers as second step i will investigate the role of the mediterranean outflow water in the thc and the shift in oceanclimate dynamics during a welldocumented major climate shift ie the earlymiddle pleistocene transition 1207 million years ago when the 41kyr glacialinterglacial cycles were replaced with 100kyr abrupt cycles execution of this project will allow me to enhance my scientific portfolio by learning a new technical instrument joining a new research group in an internationally fastgrowing research center having the opportunity to manage my own research budget and benefitting from the experience of the chosen supervisor which are positive impacts for an early career scientist in becoming an established independent researcher
rewriting rights feminist legal narractors from arendt to womens courts

the scene of the trial has always been at the core of feminist theories and practices of law since it has often been identified as the space in which womens voices and bodies could break into the legal scene in order to claim for justice the project aims to broaden our gaze of the legal scene adopting a new perspective those of women who even if they are not the main legal actors judges lawyers plaintiffs engage with the language of rights in order to retell rewrite or restage a trial from their situated position their voices do not limit to narrate the event of the trial but actually perform a retrial with the dual aim of highlighting the failure of the legal language in doing justice and offering alternative possibilities to regenerate and resignify it from arendts pioneering report on the eichmann trial to the experiences of womens courts these both critical and creative practices are disseminated in the feminist field but they have never been studied together through the newly defined concept of legal narractors this ambitious and timely project aims to produce the first study of these narrative and performative practices of retrial which have the merit of promoting a critical but not fatalistic approach to justice using as starting point of the reasoning in line with the feminist situated knowledge the story of a case rather than a theoretical abstraction the main objective of the project is threefold 1 empirically to build an archive of feminist narrative and performative practices of retrial 2 conceptually to provide a definition and a theoretical framework for the new expression legal narractors 3 normatively to explore how main legal categories such as equality difference recognition gender subject of rights victim witness truth and truthseeking and reparation are resignified by these practices
facilitating personalised lung treatment decisions through a deeptech ai clinical decision support system

with the support of eic funding thirona aims to transform their innovative thoracic ai imaging system lungq into an endtoend clinical decisions support system cdss called lungqcare the current information workflow of thoracic imaging makes it exceedingly complicated to personalise lung treatments however lungqcare tackles this challenge by enabling radiologists to quantify medical imaging and disease phenotypes to deliver structured analyses to lung doctors this empowers them to interpret medical imaging effectively and offer personalised treatments to their patients for optimal disease management while reducing costs lungq displayed clinical impact by reducing anaesthesia induced bronchoscopic interventions by 815 for copd cases additionally lungq reduces the time to analyse cystic fibrosis images from days to minutes with medical and technical expertise thirona has the capabilities to lay the foundation for a scalable and groundbreaking ai platform in lung care
enhancing the insitu environmental observations across undersampled deserts cirocco

ciroccos vision is to establish an endtoend sensing system composed of a distributed network of costeffective sensing nodes coupled with stateoftheart data fusion remote sensing and assimilation modelling techniques a mix of wireless communications including satellite and local wireless sensor networks is used for the collection of data the defined network of sensors will enhance the current lack of ground observation in desert areas covering egypt serbia and spain offering an operational and in parallel easy to maintain and expand solution four services are developed i renewable energy systems planning ii air quality early warning system for human health iii land use and ecosystem management iv modelling of ghgs and particles emissions to validate the quality of the collected data and drive the sustainability and exploitation path of the overall system cirocco performance and capabilities will be tested and validated in reallife settings in four large in cyprus egypt serbia and spain commercialisation services ensure the sustainability of the installation and in parallel fair management of data will support crosscopernicus ecosystem integration and assimilation services
bioprospecting and production of bioactive molecules from european bryophytes

liverworts an ancient group of land plants are a rich and yet still underexploited source of a wide range of biologically active compounds with high potential for the bioeconomy sector as ingredients of cosmeticscosmeceuticals and pharmaceutics however their slow growth rate in nature and the consequent difficulty to obtain large amounts of single compounds have until now severely hindered the indepth exploration and exploitation of the full spectrum of activities of liverworts secondary metabolites recent breakthroughs in the identification of some of the genes involved in the early steps of liverwortspecific compounds suggest that in addition to the establishment of improved methods for growth in axenic conditions reconstruction of liverwort metabolic pathways in heterologous systems is a promising way forth towards the practical exploitation of liverwort biochemical diversity and its industrial scale upthe bryomolecules project will use a combination of cultivation of axenic cultures and production of the active compounds in heterologous systems to define the most suitable production platforms for their largescale production the project will achieve a very sustainable use of the chemical diversity of wild eu bryophyte species a largely untapped source of high addedvalue natural products without significant impacts on their biodiversitybesides the identification of relevant lead compounds for cosmeticscosmeceuticals and pharmaceutics another major impact of the project will be the production and release according to fair principles of a database of metabolites and biosynthetic genes of european bryophyte species that will fuel in the years to come the development of novel biobased products based on bryophytederived lead compounds according to the concept of eu valorizing biodiversity for eu bioeconomy
decoding diabetic kidney disease

diabetic kidney disease dkd is a rapidly growing worldwide health problem and represents one of the most serious threats in current medicine dkd is the most common cause of chronic kidney disease ckd with 20 of dkd patients progressing to endstage renal disease which is associated with tremendously increased morbidity and mortality the pathophysiology of dkd is complex incompletely understood and the number of treatment options is low the vision of decodedkd is to utilize a patientcentric research approach to identify novel pathways and druggable targets in patients suffering from dkd concrete objectives are 1 to establish a spatially resolved multiomic landscape of human dkd 2 to dissect and identify therapeutic pathways and signalling networks for novel drug target identification 3 to incorporate patientderived invitro models for target validation it is envisaged that novel spatial and singlecell multiomic technologies will generate a blueprint and predictive model of dkd this unbiased map will serve to generate testable hypotheses with spatial and temporal coordinates at singlecell resolution to identify diseaserelevant pathways and novel drugable targets invitro and invivo genome editing approaches will be employed combined with highthroughput screens invitro assays with humanderived kidney organoids will be used to screen potential compounds facilitating the development of novel therapeutics this highly ambitious interdisciplinary proposal requires the expertise of biomedical engineers computational biologists biomedical researchers and physicianscientists the generated knowledge and outcomes of decodedkd will alone and especially together be truly transformative and provide an incremental step forward towards novel drug targets and precision medicine for the treatment of diabetic kidney disease using a systems medicine approach
algorithms for structural variation analysis in challenging genomic regions

structural variations are genomic alterations affecting portions of the chromosomes longer than 50 base pairs these alterations are a main contributing factor to human diseases and different types of cancer the main limitation of current approaches for the analysis of structural variations lies in their unreliability in characterizing these alterations in repetitive and hardtocall regions of the genome structural variations falling in these regions can not be routinely detected and their significance is still unknownin this proposal we aim to develop novel computational approaches to address the challenge of fully characterizing structural variations in these hard and still uninvestigated regions by developing accurate tools for comprehensive detection of structural variations we aim to increase our current knowledge of this class of genetic alterations moreover by designing new benchmarking methodologies we will provide a more accurate evaluation of our as well as other tools this will also assist the development of new generations of tools able to accurately characterize structural variations that are currently unknownwe will employ a multifaceted strategy that is not limited to a single sequencing technology by combining data coming from different sequencing technologies and ideas coming from alignmentbased assemblybased mappingfree and pangenomicbased approaches we will be able to take a significant step towards the complete characterization and analysis of structural variationsthe development of new tools and the planned collaboration with biologyoriented research groups will enhance our understanding of the impact of structural variations on human health diseases and cancer and hence improve clinical diagnostics and pave the way for personalized medicine
streaming flexibility to the power system

the ambition of the stream project stream is the creation of an innovative and robust flexibility ecosystem stream ecosystem on the low voltage lv grid side of existing power markets connecting data technologies stakeholders and markets thus facilitating the flexibility provision a variety of benefits for both technical and nontechnical aspects of energy services supporting power market and power grid operations will be created stream will empower data from flexible devices and support creation of other citizen services through a usercentric approach to improve their acceptance the exploitation of both types of services will benefit from new business models built upon local lv flexibility markets and novel barterlike mechanism developed in streampresently such services and business models dont exist in either established or developing power markets the stream ecosystem covers their implementation includes various stakeholder groups on all levels of power markets from smallscale endusers energy communities escos service providers to market and system operators to achieve the goals stream consortium comprises relevant actors to capture the entire flexibility value chain within stream ecosystem from end users energy communities to service providers flexibility services providers market operators dsos and tso complemented by technology and research partners the latter will supply knowledge in a form of stream tools that will enable the realization of stream ecosystem they will be adapted deployed calibrated and demonstrated in the 4 stream pilots that serve as a basis for benchmarking of stream ideas they cover geographical economic size and type diversity of the consumers while complementary the pilots focus on a specific part of stream ecosystem the pilot partners have all the essential roles and authority to carry out the specified activities
organonachip focused strategic partnership

orchestra project aims to build solid and productive links between odtü mems turkey and three internationallyleading counterparts tue the netherlands imec belgium and ufr germany in order to strengthen scientific and research capacity of biomems research unit of odtü mems by raising the research profile of its staff and broadening its recognition as a centre of excellence in the field of microfluidics biosensors and particularly organonachip systems with the four twinning partners in place odtü mems aims to acquire the expertise needed not only to fill the identified gaps regarding knowledge capacity and networking but also to join leading networks of excellence in microfluidics biosensors and organonachip based research areas as an equal partner the consortium expects to expand the rd capabilities of the partners to attract and provide scientific personnel via the orchestra to the thematic focus of microfluidics biosensors and organonachip systems contributing to critical mass for the widespread application of such promising systems empowering the partnering organisations will result in knowledge transfer joint publications and future research projects the consortium is strongly committed to further develop this partnership with a longterm sustainable horizon of cooperation beyond the projectconsequently orchestra project aims to promote new opportunities for the consortium members via development of productive and sustainable links among them for higher levels of excellence in the field of microfluidics biosensors and organonachip platforms with a major focus on enhancing the range of competences of the coordinator objectives dedicated to achieve this goal1 raising the research profile of odtü mems and its researchers2 enhancing institutional capacity of odtü mems3 excellence in the wider impact for the ecosystem and beyond4 integration into european networks of excellence
accelerating the sustainable production of advanced biofuels and rfnbos from feedstock to enduse

fuelphoria will demonstrate the establishment of sustainable complete value chains for advanced biofuels and rfnbos for providing europe with sustainable secure and competitive energy supply schemes the project will practically showcase a portfolio of nine complete value chains which will be set up and tested in real environment contexts with the active participation of all key players including the feedstock suppliers two biogas plants a winery plant an urban waste treatment plant the technology providers who will convert through chemical electrochemical biological thermochemical and photobiological processes the feedstock co2 digestate urban municipal biowaste into an array of advanced biofuels and rfnbos light to long parafins ie ch4 mediumlong chain hydrocarbons esters ie biodiesel and light alcohols ie ethanol methanol that meet quality specifications as defined by the endusers in the transport sector aviationmaritime road transport and in the power production sector gas or oil fired thermal plants through four demos in europe belgium spain greece while european export potential through international collaboration with africa is also envisaged special emphasis will be also given to the logistics around the fuel production systems ie for the sustainable supply of feedstock and the efficient transport of the final products to their end application to do this across the fuelphoria project the value chain approach is combined with the life cycle assessment approach in order to not only consider all the different stages of the value chain from feedstock to end use but also to explore how the value chain operates as part of a larger system fuelphoria will define and setup business models and marketing concepts and prepare market entry of the technology solutions as well as of the endproducts and will develop policy recommendations for realising the energy system transition potential
its the symmetry stupid gearing up tensor networks for the topological quantum revolution

this proposal is set in the era of the second quantum revolution in which there is a strong need for a computational framework to describe and simulate topological materials and quantum devices possessing exotic particle statistics the two leading actors symmetries and tensor networks the story while the topological materials seem to defy landaus symmetry breaking paradigm as they do not exhibit a local order parameter tensor networks strike back with the emergence of a local pullingthrough symmetry of the local tensors describing them the catch the symmetry happens in the shadow world of entanglement degrees of freedom is in general noninvertible and speaks the language of bimodule categories the magic the tensor network picture makes the abstract concepts and mathematical tools needed to describe topological and critical systems such as cohomology theory and bimodule categories very tangible and concrete as wavefunctions of quantum spin systems which can easily be put on a computer the mission develop the mathematics of tensor network representations of higher categorical and noninvertible symmetries construct a computational toolbox which exploits those symmetries construct explicit matrix product operator intertwiners for dualities between theories with nonabelian categorical symmetries construct novel cfts from categorical data create a bridge between bimodule categories and integrability the crescendo tensor networks with categorical symmetries take over the world by 1 setting up realspace renormalization group flows in which unwanted relevant perturbations are crushed and 2constructing and evaluating quantum error correcting codes based on nonabelian anyons the takeaway deep theoretical ideas and state of the art computational aspects are not parallel lines of development but are one and the same and must be fused with each other the moral for things to remain the same everything must change
highthroughput ultrasoundbased volumetric 3d printing for tissue engineering

cardiovascular diseases are the leading cause of death globally efficient drug testing and disease models are needed to reduce their death toll myocardial cell constructs eg spheroids organoids or organs on a chip hold promise as disease models and can reduce animal testing unfortunately cell constructs often lack the natural spatial complexity of their invivo counterparts and consequently the cells remain immature and nondifferentiated although 3d printing offers great flexibility regarding the printed structure some limitations apply the printing process is either slow or not suited for printing the smallscale nested structures needed to create viable and functional myocardial cell constructs to 3d bio print viable myocardial cell constructs we must therefore break through several roadblocks limiting the potential of bioprintingour solution coined sonocraft combines rapid volumetric 3d printing technology with ultrasonic particle manipulation to create centimetrelong aligned cardiac constructs within hydrogels an artificial vasculature incorporated within the hydrogel matrix assures perfusion with oxygen and nutrients acoustic particle manipulation our tool of choice for cell manipulation as it is cheap biocompatible labelfree and achieves the required resolutionto reach the objectives sonoprint is equipped with a range of advanced features i an acoustophoresis chamber for precise cell patterning in 3d ii microfluidic nozzles for injecting multiple cell types iii moveable printheads for flexible cell deposition iv a temperaturecontrolled cell culture incubator and v full automation for userfriendly operation the visionary sonocraft holds potential to transform tissue engineering regenerative medicine drug screening and disease modelling with its technological breakthroughs overcoming current limitations in the field
pathways towards a fair inclusive and innovative data economy for sustainable food systems

the digital transformation of food systems has entered a twilight zone datadriven innovations have proven to be promising but it is still unclear how to upscale adoption and have broader acceptance the data4food2030 project aims to improve the data economy for food systems de4fs by expanding its definition mapping its development performance and impact to create new insights and opportunities this contributes to a more competitive and sustainable food system in the eu and supports implementation and adaptation of relevant policies such as a digital single market green deal and the common agricultural policy data4food2030 is a 4year project that aims to 1 enlarge the knowledge base and insight into the de4fs 2 develop a system that monitors and evaluates the development performance and impact of the de4fs on relevant eu policies 3 identify drivers and barriers and turn these into opportunities recommendations and solutions 4 test solutions and evaluate recommendations in case studies and through stakeholder dialogues and 5 provide future scenarios and a roadmap and sustain the monitoring system to support policy development and accelerate the desired future state of the de4fs data4food2030s approach is targeted at an improved future state of the de4fs from which clear design principles recommendations and solutions are derived for improving and adapting policies and practices at public and private level as an essential part of the project stakeholders are deeply engaged to provide input to various de4fs concepts and evaluate several project outcomes to increase the impact of the project nine case studies provide reallife examples of the de4fs at micro and mesoeconomic level deploying data and technologies which are used for mapping and improvement to promote dataenabled business models in this way data4food2030 creates credible pathways to navigate properly through the twilight zone towards a fair inclusive and innovative de4fs