Dragon09/odtu_chatbot huggingface dataset:
orchestration and programming energyaware and collaborative swarms with aipowered reliable methods

lowpower wireless technology tends to be used today for simple monitoring applications in which raw sensor data is reported periodically to a server for analysis the ambition of the openswarm project is to trigger the next revolution in these datadriven systems by developing true collaborative and distributed smart nodes through groundbreaking ri in three technological pillars efficient networking and management of smart nodes collaborative energyaware artificial intelligence ai and energyaware swarm programming results are implemented in an open software package called openswarm which is verified in our labs on two 1000 node testbeds openswarm is then validated in five realworld proofofconcept use cases covering four application domains renewable energy community cities community supporting human workers in harvesting environmental ocean noise pollution monitoring environmental health and safety in industrial production sites industrialhealth moving networks in trains mobility a comprehensive dissemination exploitation and communication plan including a diverse range of activities related to standardization educational and outreach open science and startup formations amplifies the expected impacts of openswarm achieving a step change enabling novel future energyaware swarms of collaborative smart nodes with wide range benefits for the environment industries and society
prostarget understanding the aggressive nature and key molecular drivers of metastatic dissemination in lethal pca

cancer cells dissemination from primary tumors to distant sites is the most terrifying evolving process of cancer such an irreversible and irreparable process encompasses tumor cells escaping extravasating into blood stream and colonizing distant sites and is known as metastasis origin metastases spread is the leading cause of cancerrelated deaths the scattered but aggressive nature of metastatic disease and the extensive but not striking treatment effort history of metastatic cancers represents still a major obstacle in scientific progress and curability rates stemming from translational cancer research prostate cancer pca hits men with high incidence and shows heterogeneity and resistance to standard of care altogether those hints imply that patients exhibiting disease progression will head into complications succumbing to pcarelated high mortality representing a major socioeconomic problem worldwide importantly pca metastasis strikes after resistance acquisition to antiandrogens and taxols overall limiting treatment efficacy in this context cancer research is vital with the aim of shedding new light on causal factors unrevealing molecular mediators of the metastatic process responsible for treatment resistance leading to patients poor overall survival finding those responsible mediators represents still an unmet medical need to reduce pca mortality rate here we undertake an innovative translational approach to identify molecular cues underlying metastatic pca we focus our attention on a poorly characterized cancer entity castrationnave metastatic pca encompassing a tumor type that is metastatic at the time of first diagnosis this tumor type is responsible for more than 50 of lethal pca in the developed world through the project we will unleash prostate cancer vulnerabilities to finally improve patient overall survival for this reason we built prostarget
exosome characterization platform for early detection of breast cancer

breast cancer is the most common cancer among women worldwide early detection is the most critical element as the survival rate increases by up to 99 although there are conventional screening techniques such as mammography breast cancer is still the second leading cause of cancer death in women one of the holy grails in cancer research is to develop a blood test for early detection sensitive noninvasive and easytouse liquid biopsy techniques will revolutionize cancer diagnosis and treatment monitoring the goal of this project is to develop a complete platform for the isolation and labelfree optical characterization of biological nanoparticles called exosomes extracted from blood exosomes are secreted from the cells into the body fluids and play an important role in intercellular communication these particles are emerged as potential biomarkers for liquid biopsy applications as they carry information about their original cell however the translation of exosomebased analyses from research labs to clinical settings is limited due to the lack of efficient isolation and quantification tools available we aim to develop a novel exosome characterization platform named multimodal interferometricraman imaging platform to detect and quantify exosomes at a singleparticle level without using any labels the combination of the labelfree imaging capability of interferometric microscopy and the chemical content information provided by raman spectroscopy will be an important step for exosomebased diagnostics applications the proposed system will be integrated into a stateoftheart isolation tool creating complete isolation and multiparameter characterization platform the proposed platform will be tested with the exosomes isolated from tumor cells to determine possible biomarkers that can be used for diagnosis the diagnostic capability of the system will be validated with healthy donors and breast cancer patients30 persons each
bioprocesses for metabolite production from marine invertebrate cell lines

the objective of blues is to expand the potential to produce valuable and unique bioactive compounds from marine invertebrates by developing novel cultivation systems of cell lines from 4 phyla of marine invertebrates porifera cnidaria echinodermata chordata and optimizing production yield as an alternative to wild harvesting for many years research has been done to derive continuous cell lines from invertebrates only recently blues partners reached a breakthrough and created the first continuous marine sponge cell line results demonstrated that sponge cells of several species can divide extremely rapidlythe ambition is to design the pathway towards industrial bioprocesses using marine invertebrate cell lines of different phyla as a chassis towards the production of unique highvalue marine biobased compounds an environmentally sustainable alternative to wild harvesting the novel bioprocesses that will be developed are not only an alternative for wild harvesting solving the stock production bottleneck for increased availability of the bioactive compounds but also for a higher level of sustainable alternative contributing to the development of circular processing and circular economythe technology that will be developed in blues will make it possible that valuable marinenatural products are produced in bioprocesses and with that contribute to the blue bioeconomy
colourful predictions unraveling the resolution and neural mechanisms of colour expectation

whether doing sports or driving through city traffic our visual system constantly builds expectations to predict and quickly react to upcoming events however despite the great importance of expectations their form and neural implementation remain a mystery it is completely unknown whether expectations encode a clear picture of the anticipated visual input or just a rough sketch this gap in knowledge is vital since only things encoded in our expectations are expected to enter conscious awareness faster given the high value of colour signals to guide attention in everyday life eg traffic signs this project asks where and when in the brain colour expectations are formed and if they are in full colour or just comprised of few basic hues to track cortical colour expectations with high spatiotemporal precision electro and magnetoencephalography will be combined with anatomical brain scans and cuttingedge computational decoding in a new integrative approach first a decoding model will be built that reconstructs colour from brain responses applying this new model to brain activity of participants anticipating colours will elucidate when and where in the brain colour expectations are formed combined behavioural and electromagnetic measures will then determine the influence of these expectations on our perception finally combining the decoding model with colour similarity levels and individual colour categorizations will clarify the resolution of colour expectations this project will be the first to unravel the neural mechanism influence and limits of colour expectations together with the decoding model as future tool this will open new perspectives on predictive processing perception and imagery but will also have widespread societal implications designing of better recognizable colour traffic signals improving colouring schemes in school books to more effectively guide attention and even for decoding brain responses of lockedin patients
an atlas of organisation of lipids in extracellular vesicles to navigate their roles in cancer metastasis

it is estimated that up to 90 of cancer deaths are caused not by the primary cancer but after it has metastasised ie spread to other organs in the body and it is well known that the locations of metastasised tumours are specific to the location of the primary cancer communication and transfer of material between cells is a fundamental process in cell biology for which nature uses extracellular vesicles evs these nanometresized vesicles are excreted by cells and contain signature combinations of membrane lipids nucleic acids proteins and surface markers evs excreted by cancer cells play an important role in communication between tumours and distant organs where metastases can take hold while more is now understood about the role of ev nucleic acids proteins and surface markers in these processes the role of ev lipid composition and especially the role of asymmetric lipid distribution across the membrane remains overlooked i address this fundamental research question by developing an interdisciplinary approach for mapping the asymmetric lipid composition of evs with varying prometastatic nature from a library of cancer cell lines i will create an atlas of asymmetric lipid compositions of evs excreted by cancer cell lines including quantitative data on the asymmetric lipid distribution between the inner and outer membrane leaflets asymmetric lipid distribution to study the role of ev lipid composition on selective uptake in cells from the original tumour and premetastatic environment i will apply neutron scattering and superresolution microscopy techniques taken together the atlas of cancerderived ev asymmetric lipid compositions that i will develop represents a significant advance to the state of the art and a groundbreaking combination of cell biology with engineeringbased tools for chemical and biophysical indepth characterisation of complex asymmetric membranes
innervationdriven mechanisms of bile duct development

while liver development is wellstudied the signal initiating tubulogenesis of bile ducts therein remains to be identified neurites are present in the liver before bile duct tubulogenesis and in other organs innervation can instruct tubulogenesis however a role for liver innervation in biliary tubulogenesis has not been shown preliminary data from my host lab suggest a strong link between both processes defective biliary tubulogenesis caused by notch mutations in alagille syndrome algs is preceeded by a lack of liver innervation i will test the hypothesis that intrahepatic innervation initiates biliary tubulogenesis first i will apply 3d staining and imaging techniques to study the establishment of intrahepatic innervation at multiple timepoints during development and quantify characteristics of innervation in healthy and algs mice in depth using automated image analysis secondly i will investigate if liver innervation is required for tubulogenesis by performing nerve ablation studies and analyzing its effect on biliary cells finally i will establish a method to perform transcriptional profiling of liver innervation the liver is only innervated by nerve endings from extrinsic neurons and these neurons have their cell bodies in ganglia outside of the organ where also other neurons reside it has thus not been possible to isolate these cells from the liver and analyse their expression profiles using a viral barcode library to label neurons and their axon endings i will perform singlecell rna sequencing on those ganglia and identify and characterize the cells innervating the liver enabling expression profiling of extrinsic nerves will be a game changer in the field of organ innervation and can be applicable to numerous other fields this project will provide fundamental insights into the developmental functions of liver innervation and the molecular mechanisms underlying biliary tubulogenesis providing a basis for future therapeutics
mapping endangered cultural soilscapes in postconflict regions through big earth observation data artificial intelligence and geoarchaeological signatures

signature aims to investigate the longterm settlement and land use dynamics that shaped the cultural soilscapes of the levant with a particular emphasis on revealing new archaeological sites that have been obscured by recent agricultural encroachment and abrupt land disturbances the study area encompasses the endangered archaeological landscapes of the bekaa valley in lebanon and its adjacent fertile plains between the litani and orontes rivers as an aftermath of the lebanese civil war and the longlasting conflict spillovers that followed the traditional agronomic landscapes of the bekaa were severely transformed by agricultural autarky the scarce initiatives that are set in place to map vulnerable heritage primarily focus on wellknown monumental sites such as the unesco complex of baalbek other fragile and less visible archaeological and landscape features such as eroded earthen mounds or tells are largely underrepresented signature combines big earth observation data and geoarchaeological signatures in computational workflows to 1 accurately map and predict the location of anthropogenic soils and landforms 2 monitor historical and presentday land use trends and 3 identify acute landscape transformations affecting the preservation of vulnerable archaeological and heritage assets a key aspect of the project methodology is the integration of multisource and multitemporal satellite data in artificial intelligence procedures coupled with ground and highresolution soil proxies in advanced geostatistical workflows signature will produce and share a set of comparable data and reproducible tools for the study and management of endangered cultural landscapes likely to be adapted and implemented by scholars and cultural heritage practitioners working in conflict and postconflict regions
severe neonatal infection adaptive platform trials in africa

snipafrica aims to establish a clinical research network and architecture to implement adaptive platform trials in subsaharan africa ssa responding to the urgent need for improved treatment of childhood infection in an era of increasing antimicrobial resistance amr snipafrica focuses on the highburden highimpact group of inpatient neonates and infants with sepsis this is a group especially affected by escalating rates of amr in ssa healthcare facilities contributing to much slower than desirable improvements in neonatal mortality across ssa the project will address all aspects of apts in neonatal sepsis from defining potential treatments of interest to translation into clinical guidance and will deliver interventional studies in the two domains of neonatal dose confirmation and drug regimen selection the network and architecture could be readily extended to include older children in hospital with infections with epidemic potential snipafrica will achieve its aim by bringing together partners from the global north and ssa including several with experience in designing and running adaptive platform trials and complex randomised controlled trials in ssa the project therefore builds on existing expertise and capacity to enable an innovative response to the major threat to child health of amr through a new architecture and extended network the work plan includes project management coordination and communication wp1 clinical and microbiological surveillance wp2 adaptive platform core protocol and governance wp3 pharmacokinetics for adaptive platform trial wp4 complex adaptive drug regimen trial wp5 training and capacity building for adaptive trials wp6 and stakeholder engagement and integration wp7 snipafrica aims to trigger a paradigm shift in interventional research in severe childhood infection and to equip a network of ssa institutions and researchers to conduct innovative efficient targeted research in this area
optical entanglement of nuclear spins in silicon

a major breakthrough in quantum information processing is expected once qubits carriers of quantum information can be reliably integrated and controlled in silicon the basis of todays advanced classical information technology previous qubit realizations used the electronic spin of quantum dots or dopants ie atoms of a different species replacing silicon in the lattice however this approach has only allowed for the entanglement of qubits in immediate proximity which has hindered increasing the size of siliconbased quantum information processing systems in openspins these limitations will be overcome by using the nuclear spins of erbium dopants as qubits these are initialized readout and controllably entangled using photons in the minimalloss band of existing fiberoptical infrastructure to demonstrate the unique potential of this approach the specific objectives of the proposal are i the fabrication of nanophotonic resonators with unprecedented purcell enhancement to enable coherent spinphoton coupling ii the direct optical addressing and control of nuclear spin qubits with long coherence and iii the implementation of opticallycontrolled twoqubit quantum gates and entanglement both within a node and over distance the proposed system combines the advantages of two leading platforms for quantum information processing the bandwidth and longdistance connectivity of photons at telecommunications wavelength with the robust control and hourlong qubit storage achievable with nuclear spins in silicon as the proposed chipintegrated resonators can be manufactured using established processes of the semiconductor industry the novel hardware platform implemented in openspins offers unique prospects for future upscaling of quantum information processing systems and quantum networks
grip on mash global research initiative for patient screening on mash

grip on mash will address the unmet public health need of reducing disease burden and comorbidities associated with metabolic dysfunctionassociated steatotic liver disease masld together with seven medical technology pharmaceutical and biotechnology companies we will devise a sustainable and scalable grip on mash platform that will enable access to atrisk patients developing or having masld through the early detection of this condition at the primary care level this platform will allow a the early detection of patients with masld distributed in 12 european centers of excellence coes 10000 patients at high risk of masld defined as patients with type2 diabetes mellitus metabolic syndrome obesity or arterial hypertension will be screened and characterized b better patients stratification the platform will comprise artificial intelligencebased decision support tools that will make use of existing and novel biomarkersbiomarker combinations their predictive accuracy will be tested at the primary care level there we will perform multiomics analysis proteomics lipidomics metabolomics genomics metagenomics and fluxomics in fasted blood samples and we will explore imaging biomarkersorganonachip to find future noninvasive diagnostic alternatives for the current standard liver biopsies and c personalized lifestyle advice by exploring evidencebased lifestyle features and the effect of nutritional recommendations among the cohorts at the coes we will use validated questionnaires to assess physical activity diet sleep smoking alcohol consumption and perception of stress integrating patients perspectives with the participation of two patient organizations the trustworthiness and sustainability of our grip on mash platform will be assessed by investigating potential economic ethical and regulatory barriers to its future adoption grip on mash will change healthcare practice in masld and reduce the disease burden for patients
foster research excellence for green transition in the western balkans

greenforce aims at fostering excellence in the western balkans green transition scientific research and innovation of coplan albania cea north macedonia and ubgef serbia as a means to enhancing their research profile strengthening research and management capacities of their staff and contributing to convergence between western balkans wb and eu research capacities as well as to wider policy initiatives for the wb region this objective is reached through the twinning partnership of five organisations that will work closely to produce territorial knowledge through exploratory research and institutional learning
european holocaust research infrastructure ehri implementation phase

the vision of the european holocaust research infrastructure ehri is to secure seamless access to all sources and expertise from across europe and beyond that are relevant to the study of the holocaust it approaches this vision through the development of a paneuropean distributed research infrastructure that brings together the leading facilities and offers users integrated access to holocaust resources expertise and training in 2018 ehri was added to the esfri roadmap and is currently finalising a step1 application to establish a new european research infrastructure consortium eric supported by eleven countries the ehriip project will facilitate ehris implementation phase and ensure a timely start of its operation as an eric the ehriip consortium consists of representatives from the emerging national nodes of the eleven countries that expressed support for establishing ehri as an eric as well as partners from ukraine and the united states this consortium will undertake a set of coordinated activities that will advance ehris maturity and capabilities and remove any remaining roadblocks to its implementation and early operation the project will achieve three overall objectives i to implement ehri by finalising the governance establishing an operationready central hub and linked national nodes and turning existing highlevel scientific user and technological strategies into operational reality ii to grow ehri by acquiring new potential member and observer countries negotiating cooperation agreements with international and strategic partners and investigating the scope for a future expansion of ehri with regards to the scientific domain covered services offered and user communities served iii to manage and valorise ehri by coordinating between ehriip and concurrent activities and developing strategies that ensure that ehri reaches its full potential with regards to innovation and social economic and scientific impact