Dragon09/odtu_chatbot huggingface dataset:
nonviral gene modified stem cell therapy

despite the increasing awareness that cell and genetherapy approaches have tremendous biomedical potential their broad clinical application has been challenging due to prolonged and expensive production times and the emergence of severe immune and genedelivery dependent side effects in this proposal we aim to establish a streamlined and highthroughput protocol for ipscbased cell therapy by combining a novel technological platform for gene delivery with a breakthrough biological concept that will permit to manufacture functional genecorrected blood forming stem cells and car t cells to achieve this we will use and optimize photoporation as nonviral gene delivery method for crisprmediated and sitespecific geneediting to obtain controlled car expression and for performing genecorrection in ipscs from these genemodified ipscs we will generate car t cells and blood forming stem cells respectively by selectively targeting a signaling pathway that we established to be critical in human blood cell development and particularly t cell development following functional validation of the generated cell products we will optimize the current protocols to increase the potential for clinical implementation and establish a highthroughput photoporation platform to generate a large number of car expressing ipsc lines from different ages sex and ethnicities to demonstrate the populationwide implementation potential of our approach this will allow to generate a bank of wellcharacterized hladefined car expressing ipsc that can be used as oftheshelf cell therapy products thereby significantly advancing the currently implemented adaptive car t cell approaches by reducing the production costs and time by selectively targeting the car into a wellcontrolled location which will prevent variability and by facilitating the production and evaluation of novel cars for other cancer entities such as solid tumors
young homeownership

consider a household looking to buy a house in attractive locations this household competes with other buyers to purchase their desired property since the number of listed properties is limited in this scenario what is the impact of subsidizing a given group what is the impact of a change in public policy that affects one group more than others do households respond to the policy by changing their preferences yoho young homeownership builds on a simple yet powerful insight if a buyer is competing against other buyers from the same group then changing financial conditions for that group will not change their access to the housing market but may affect how much they can pay the insight that yoho proposes to formalize is that if a policy targets a large share of buyers subsidizing them will likely not lead to higher homeownership rates but to rising prices moving beyond marketlevel outcomes yoho will further dig deeper into the potential side effects for young buyers such as limited access to attractive locations yoho will combine norwegian register data natural experiments and theoretical modeling in line with the stateoftheart housing literature to answer questions of large importance for society the economic situation for households and future research into affordability and homeownership access to the housing market is an ongoing societal challenge in many countries that involves the general public policymakers and academics the work in yoho is at the core of this challenge with the potential to make a meaningful contribution to the debate the research will be conducted under professor florian heiders guidance at the leibniz institute for financial research safe which aims to produce original highquality research and researchbased policy advice in all finance areas and a regular and permanent exchange with members of governments parliaments central banks and supervisory authorities in germany and europe
modelling and control of flexible structures interacting with fluids

the modconflex consortium comprises a group of 10 academics and 4 senior researchers in industry ore catapult with expertise in control theory artificial intelligence complex dynamical systems distributed parameter systems fluid dynamics aeroelasticity power electronics power systems swimming theory and marine engineering our aim is to train the next generation of researchers on the modelling and control of flexible structures interacting with fluids water and air contributing to the latest advances in control theory artificial intelligence and energybased modelling our main applications are in the control of floating wind turbines the prime renewable energy source of the future and in the control of highly flexible aircraft aircraft with very high aspect ratio our research plans are organized into three scientific work packages which cover mathematical systems theory modelling and model reduction boundary control systems porthamiltonian systems exact beam theory relevant aspects of control theory internal model controllers with antiwindup nonlinear model predictive control robust control reinforcement learning aeroelasticity stochastic algorithms we believe that science and technology in europe will greatly benefit from this research and from the education and knowledge that we will impart to a new generation of researchers key strengths of this consortium include a research environment that brings together mathematicians and engineers to provide the projects young researchers with a unique training environment and a network of associated industrial partners that will allow all the young researchers to participate in industrial secondments we have the critical mass to cover all aspects of training and we have an excellent track record of past collaboration and of training young researchers
the role of gender in virtual work environments

virtual forms of interaction at work are gradually replacing the traditional inperson work style across many knowledgeintensive industries and this change could signal the beginning of a lasting shift in how work is conducted despite obvious benefits this emerging trend also raises an array of complex challenges namely related to inclusiveness and participation in virtual work environment understanding the complexities of inclusive interactions in these digital environments and what new challenges may arise is a crucial issue as a first step this proposed research program seeks to focus on female participation and engagement on virtual work settings in doing so it aims to investigate how interactions from and towards women are different compared to their male peers in virtual work environments what are the drivers of potential differences and finally how digital platform architecture and design opportunities could be exploited to alleviate the barriers to female participation and interaction in these emerging work settings to address these questions a largescale randomized vignette survey experiment with actual professional respondents is proposed the results of the proposed experiment can enhance our understanding from the new virtual form of work and could generate implications for companies on how to arrange and design their virtual work environments
a design study for a muon collider complex at 10 tev center of mass

two facility concepts have been considered as potential pathways to the future of particle physics at the energy frontier in europe fcchh a 100 tev circular hadron collider and clic a 3 tev linear lepton ie electronpositron colliderthe recent european accelerator rd roadmap includes a novel option a 10 or more tev muon collider which expands the lepton collider energy reach and promises compact dimensions high efficiency and limited costmuons are pointlike particles in contrast to hadrons a 10 tev muon collider would have a comparable physics case for a number of physics processes to a 100 tev hadron colliderthe muon collider promises high benefit but also faces a significant risk as it is the first of its kind and uses novel advanced technologiesthe mucol design study will address the core challenges identified in the roadmap develop the concept and technologies and demonstratethe physics case of the muon collider is sound and detector systems can yield sufficient resolution and rejection of backgroundsno principle technological issues will prevent the achievement of a satisfactory performance of the accelerator or the detectorsthe muon collider provides a highly sustainable energy frontier facility compared to other equivalent colliders andexploiting synergies with other scientific and industrial rd projects can provide europe a leading edge in discovery potential and development of associated technologiesthe final report will include a thorough assessment of benefits and risks of the accelerator and detector complex including an evaluation of the scientific industrial and societal return beyond highenergy physics the cost scale and sustainability of the complex and the impact arising from an implementation on the cern site this will allow the next european strategy for particle physics update esppu process to make informed choices for the selection of the next large collider to be built in europe
bridging greek philosophy christianity and islam an edition of the late antique testimonies of heraclitus

the chief objective of the project is to produce the first complete collection of the late antique testimonies concerning the early greek philosopher heraclitus this source collection will include an english translation of the texts in the various relevant languages mainly greek and arabic but also latin coptic and syriac and a running commentary of the testimonies highlighting both the philological and the philosophical importance of the late antique afterlife of heraclitus the project will thus also provide the very first indepth study of the reception of the thought and the tenets of heraclitus in this fundamental periodthe name of heraclitus was still resonating in third century rome fifth century alexandria and ninth century baghdad but no one has put together the existing evidence to tell that story yet the main philosophical and exegetical objective of the project thus consists not only in the analysis of the various ways in which different authors have expounded the views and the sayings of heraclitus but also in the assessment of the remarkable patterns of continuity and change that characterise the heraclitean interpretations in the broad chronological span of late antiquitythe figure of heraclitus lies indeed at the intersection of historical periods and exegetical traditions that tend to be considered separately my project aims to challenge this approach by showing that the literary and philosophical production pertaining to research fields such as greek philosophy christianity and islam has to be jointly taken into account if we want to understand both the interpretative history and the theoretical relevance of the tenets of heraclitus for this reason the project includes not only the greek reception of heraclitus but also domains neglected by scholarly research such as the gnostic writings of the nag hammadi library and the texts produced in the framework of the translation movement from greek into syriac and arabic
ritual action making deterrence matter in international security and memory politics

deterrence is the strategy of dissuading an opponent from taking an unwanted action for its prospective costs would outweigh the anticipated benefits either by the threat of effective defence or that of retaliation the role of ritual in making deterrence effective affectively charged and credible in the eyes of its practitioners has remained below the radar of the existing research ritual deterrence is the first project to pursue a ritualcentred investigation of deterrence in order to advance the understanding of the political and psychological functions of this newly foregrounded practice in international security and memory politics theoretically the project breaks new ground in fostering the understanding of ritual action in international relations the symbolic logic of which remains neglected compared to the logics of consequences appropriateness practice and habit in the study of world politics empirically it addresses the imperative for systematic crosscultural and crossdomain research on deterrence as a multimodal social practice in delivering a new description of the practice of deterrence and an overhaul of the theory of deterrence the project offers a comprehensive rethinking of the performance credibility and the presumed effect of deterrence the project will provide an innovative ritual theory of deterrence in the contexts of international security and memory politics on the example of a vital historical natowarsaw pact and different contemporary cases natorussia usarussia usachina memory laws in eastern europe the study combines discourse and practice analysis with expert interviews participant observation of military exercises and wargaming encompassing both direct and extended deterrence along traditional and emerging domains of deterrence tracing and historicising the interaction ritual chains of deterrence will generate crucial knowledge about how deterrence performances enact and legitimise political communities
improving and upscaling primary prevention of cancer by addressing childhood obesity through implementation research the prevent approach

prevent improves upscaling of primary interventions for weight control management during childhood and adolescence to reduce cancer risks in adulthood this relies on current evidence that relates excess body weight with increased cancer risk towards this end prevent applies a series of implementation research actions in the following directions first it identifies barriers to current interventions and policies preventing them from upscaling to different geographical socioeconomic and cultural settings then it introduces new multiactor and contextaware interventions along with new user engagement strategies to face the current upscaling bottlenecks
polarsense polaritonic compact gas sensor demonstrator

monitoring gases and particles through the use of smart sensors has a crucial role in a wide range of applications from environmental control to breath analysis for diagnostics with the information provided by these sensors we are able to predict prevent and act in potentially dangerous situations in order for the data to be effectively transferred the gas sensors must be integrated into portable devices with wireless connectivity and must be miniaturized concurrently to meet this requirement the sensors must possess high sensitivity selectivity speed ultralow power consumption and compatibility with silicon technology however currently no existing technology on the market fulfils all of these criteria polarsense aims out to develop an optical infrared gas sensor demonstrator chip based on a novel graphene electropolaritonic platform that is designed to address all of the aforementioned technical and commercial requirements this will be demonstrated through its functionality and performance with the capability of detecting multiple gases in a scalable cmos compatible system with a sensitivity of 01 ppm alongside specific optically active elements and an electrical detector all integrated within one single device the result is a highly compact and efficient sensing platform that does not require an external photodetector to achieve this polarsense will simulate design and fabricate a demonstrator chip in accordance with the specifications of our industrial partners and test with a compact interferometer with a broadband infrared source to evaluate the performance we will then validate the sensing performance of the demonstrator system with acetone gas in a matrix containing different concentrations of ethanol andor water vapor that are typically present in breath analyzer and environmental monitoring applications
women at work for a comparative history of african female urban professions soudn tanzania and ghana 19191970

womatwork represents the first comparative investigation into the history of female urban popular professions in three african countries ghanagold coast sudan and tanganyikatanzania over the course of fifty years 19191970 not only is this topic understudied in african history but these professions ie midwives beauticians wedding singers market vendors craftswomen are also characterised by fascinating and unsettling aspects for example notions such as a set price for a service and fixed working times or workplace did not apply to many of them womatwork aims first to discover the peculiarities of these labour patterns and see their historical transformations as a result of political changes and the introduction of new technologies and commodities secondly it examines professional subjectivities the work ethos norms and values of women at work finally it questions the relationship between these professionals and their communities including in the light of the social stigma sometimes attached to them as well as the nexus between these labourers and protest charting when and why they laid down their tools based on an innovative methodology this project seeks to overcome the invisibility of women in official archives by weaving together different threads of sources it begins inside those photographic archives connected with institutions that had conscious agendas of representation and routines of intense textual production for example missionary stations in some cases these visual and textual sources lead to networks or families of women professionals whose oral history will be solicited third the project aims to analyse the vernacular press combined with oral accountsthrough these objectives and methodologies womatwork will be a participant in the mission of writing a more democratic more inclusive history one that firmly establish the centrality of womens labour in african his
protecting and restoring biodiversity using mainstream finance biofin

if biodiversity is to be placed back on a path to recovery new tools and knowledge are required to redirect financial resources from destructive economic activity towards naturepositive investment the financial system consists of interacting and dynamic actors who value certainty rules and governance structures and efficiency outcome transparency and low monitoring costs we aim to create a unifying framework and technology that creates the enabling conditions for naturepositive investments activities that protect and restore biodiversity such as naturebased solutions are frequently unique multiactor efforts carried out at a local scale with positive but complex outcomes we resolve this by establishing a categorisation of nature based solutions nbs alongside a menu of good governance structures and a library of stakeholder engagement this will draw on expertise and best practice in natural capital and economics to streamline decision making and accelerate transaction completion by standardising the investment process and creating the enabling conditions for largescale finance to accelerate naturepositive business models we create a data analytics and underwriting engine to advance conventional project appraisal and risk assessment and account for and model expected outcomes we will assess and validate our approach across diverse reallife case studies learning sites our findings and approach will initiate a twin green and digital transition that resolves transaction complexity and creates the enabling conditions for largescale investment that are required if the eu is to achieve its biodiversity goals our outcomes will identify remaining gaps in the taxonomy and support policy forming through evidencebased recommendations and we will codesign develop and establish pathways for skills and knowledge accelerators for the european financial services industry
herccules heroes in southern europe to decarbonize industry with ccus

herccules aims at defining a firstofakind integrated and replicable approach for the implementation of the whole ccus chain to two strategic sectors of the circular economy cement and energyfromwaste efw in an area italy and greece where the industrial promise of ccus is largely unexplored leveraging on the potential of two clusters of emitters in northern italy cement efw and greece cement herccules will pave the way towards the implementation of the first fullscale ccus chain in southern europetechnological infrastructural safety societal regulatory and financial issues will be addressed by a multidisciplinary approach to build an herccules paradigm comprising nine basic chapters1trl78 demonstration of 2 flexible and retrofittable co2 capture technologies to be tested in 2 largescale cement plants 1 efw plant with residual wastebiomass feed to approach nearly zero or negative emissions 9000 h of tests2 design of the optimal co2 transport network for utilization and storage under different infrastructural evolution scenarios3trl8 geological storage of captured co2 in the two most advanced co2 sites in southern europe prinos and ravenna4demonstration in industrial environment of novel co2 mineralization solutions and reuse technologies for the production of a breakthrough hydraulic binder enabling the industrial production of a carbonsink concrete 1000 h of tests5experimentallysupported technoeconomic analyses with risk assessment to ensure the safety of the full ccus chain6advancement of societal readiness through a participative approach7identification of business models and financial mechanisms tailored to ccus 8trl89 prefeed studies on the most promising herccules implementation options9adhoc case studies to verify the replicability of the herccules paradigmknowhow data and models will converge into a dedicated exploitation plan to seed ccus across europe
advancing the zerotolerance approach to genderbased violence in higher education and research in the european research area

gendersafe advances efforts to implement a zerotolerance approach to genderbased violence in higher education and research in the european research area its overall objective is to contribute to building safe inclusive and respectful research and higher education this will be realised through building capacities mutual learning and exchange setting up instruments to monitor the uptake and content of research performing organisation rpo policies and promoting uptake of policies at the level of the national authorities and research funding organisations rfos this overall objective will be achieved through a fivefold strategy comprisingincreasing robustness of zerotolerance policies by building a common policy discourse in the eu reflecting stateoftheart theoretical debates including attention to power and intersectionality mobility and precarityfacilitating the uptake and ownership of a zerotolerance approach to genderbased violence policies through mutual learning exchange and codesign in a community of practice involving multiple circles of various types of stakeholdersbuilding institutional capacities to set up and implement genderbased violence policies through training of responsible staff and officerscreating a knowledge base on the uptake and contents of zerotolerance policies at rpos in the eu through a data collection and monitoring systemraising awareness and creating uptake through carefully designed communication dissemination and advocacy activities