Dragon09/odtu_chatbot huggingface dataset:
centre of excellence for the technologies of gene and cell therapy

scientific discoveries on mechanisms of biomedical processes and invention of technologies to repair diseaserelated genes or destroy cancer cells represent the foundation of an important pillar of personalized medicine the new centre of excellence for the technologies of gene and cell therapy ctgct will be the first centre of excellence in biomedicine in slovenia and unique with an approach combining mammalian cell synthetic biology and immunology to develop novel technologies for the development of gcts and cancer immunotherapy in the eu and beyond the aim of ctgct is to become one of the leaders in the interdisciplinary breakthrough science technologies for gct and a model for international research excellence industrial collaboration and public engagementctgct will gain a competitive edge based on the vertical integration of the technologies for whose further development the foundations have been laid at the national institute of chemistry si and with support of expertise and knowledge of the advanced partners university college london uk university medical centre utrecht nl charit universittsmedizin berlin de and technical university dresden de supported by the involvement of clinicians and patient organizations ctgct will enable translation of research achievements into therapeutic applications primarily neurological and rare genetic diseases and cancer immunotherapy and establish a capacity to prepare the gmp clinical grade therapeutic reagents which is currently a bottleneck to effective translation by bridging gap in translation ctgct will facilite high impact of excellent research and innovation on health in slovenia as well as in the west balkans east europe and beyond it will strengthen scientific capabilities and longterm collaborations with partners and others leading scientific institutions from abroad as well as improve accessibility of the gcts
brain mosaicism matters organoids in focus to unveil mechanisms in epileptogenic cortical malformations

epilepsy a global neurological disorder affecting around 70 million people poses a significant medical challenge with onethird of patients facing drugresistant epilepsy cortical malformations such as focal cortical dysplasia type ii fcdii are associated with pediatric drugresistant epilepsy for which surgical intervention serves as the main therapeutic approach for seizure control fcdii is marked by cortical dyslamination and the presence of abnormal cytomegalic cells recent findings show that fcdii results from brain mosaicism due to postzygotic mutations in genes of the mtor pathway which produces excessive activation of the pathway nevertheless as the human surgical fcdii samples represent an advanced disease stage we poorly understand its developmental origin and mechanisms moreover the link between mtor activation and epileptogenesis remains unclearto address these critical knowledge gaps a diseaserelevant fcdii model is needed for the preservation of humanspecific features i will use a mosaic cortical organoid model that expresses an inducible mtors2215f mutant construct to reflect the somatic nature of fcdii induction of the mutation at different time points will shed light on the specific time frame during which mutations occur in fcdii patients and enable us to generate a preclinical model replicating an fcdiilike phenotype next i will perform singlecell transcriptomic profiling at various developmental stages to uncover the cellular and molecular mechanisms behind fcdii development finally the neuronal network activity of mosaic fcdii cortical organoids will be characterized focusing on identifying the primary drivers of epileptiform activity among mutant cytomegalic or nonmutant nearby cells in brief this preclinical fcdii model has the potential to unveil novel developmental mechanisms offer new noninvasive avenues for treating fcdii patients with drugresistant epilepsy and boost my career trajectory in the field
chance or intentional cellular decisions explored

cells are incredibly complex outofequilibrium systems that constantly react to changing environments in an efficient and strategic manner as a consequence it is necessary for cells to make fast and accurate decisions about their functional roles to fit their needs both at short and long timescales throughout the decisionmaking process fluctuations in protein levels called noise play a pivotal role a high amount of noise allows probabilistic decisionmaking and enhances fitness when cells find themselves in variable environments however noise can be detrimental for commitment to cellular decisions requiring cells to implement strategies to minimise noise when it is unfavourable due to the prevalence and importance of cellulardecision making in healthy and pathogenic cells it is highly important to identify the molecular events that drive and modulate noise throughout the decisionmaking process this requires singlecell approaches that identify the molecular drivers modulators and enforcers of cellular decisions at both short and long timescalesin chance or intentional cellular decisions explored we will identify the molecular drivers of cellular decision the feedback architectures that modulate commitment to decisions and physical properties that enforce memory of decisions we propose an ambitious research program that maps the mechanisms underlying cellular decisionmaking by combining singlemolecule imaging singlecell sequencing and timelapse microscopy with mathematical models the results will provide a muchneeded quantitative characterization of the decisionmaking process at three distinct timescales since protein noise has been associated with various pathological conditions including infections and cancer the results from choice will have a wideranging impact
understanding the role of b cell phenotypes as a predictor of the efficacy and prognosis of allergen immunotherapy using allergic rhinitis to house dust mite as a model

allergic rhinitis ar is one the more prevalent respiratory allergic disease affecting 2030 of the global population the inflammatory process is mediated by eosinophil infiltration and ige secreted by plasma cells ige is a key component in allergies so understanding ige production and its inhibition is important for treating these diseases allergen immunotherapy ait is the only treatment that targets the etiology of allergic diseases however the efficacy of the treatment reaches 7080 in the best scenarios lower for food allergy it has a high cost and most important prediction of the effectiveness of the treatment is not possible with actual biomarkers in this proposal the candidate seeks to better understand the phenotypes of b cells key cells implicated in allergy that are modified with ait the knowledge generated by this study will provide biomarkers of ait prognosis and even predict the outcome of the therapy by analyzing the b cell compartment in patients candidate for aitusing very innovative approaches we will analyze the b cell repertoire involved in the resolution of ar through ait b cell repertoire will be analyzed in bulk before and after ait in addition antigen specific b cells will be immortalized so the antibody sequence as well as reactivity can be studied moreover we will perform an ex vivo class switch assay that could potentially predict the outcome of ait using cytokine microenvironments like those produced by the therapy and or the pathogenic situations b cell switching from igdm or igg1 to igg24 appears to be a critical step in the effectiveness in ait because ige memory resides in the igg compartment we will use ar to house dust mite patients as a model as it is one of the most prevalent allergic diseases
assessing the impact of digital technology solutions in agriculture in reallife conditions

the quantifarm project focusses on supporting the further deployment of digital technologies in agriculture dats as key enablers for enhancing the sustainability economic environmental social performance and competitiveness of the agricultural sector it will achieve this by establishing a framework for assessing the impact and effectiveness of dats in agriculture and developing innovative tools services and recommendations for farmers advisors and policy makers following a multiactor approach quantifarm will build the project activities around 30 test cases tcs which span over 20 countries in 10 of the 11 biogeographical regions across europe capturing multiple geopolitical and financial settings all 30 tcs take place in commercial farms of different types sizes ownership and operating conditions from 7 agricultural sectors different aspects of these tcs will be examined in the context of different work packages wps the tcs actors will be engaged in participatory observation activities to offer valuable input and actively support the behavioural analysis wp1 the establishment of the assessment framework wp2 and the codesign of an innovative toolkit for farmers advisors and policy makers wp3 the lean multiactor approach will be used in the testing activities to evaluate the quantifarm toolkit and validate the assessment framework by testing the various dats in real life conditions across 3 iterationsgrowing seasons wp4 the outcomes will be transformed into policy recommendations wp5 and will feed the quantifarm dia that will help build the capacities of farmers advisors in dats finally a wp on dissemination ecosystem building and exploitation wp6 will guarantee the wider dissemination and knowledge transfer in a multiactor context of the outputs of the project quantifarm includes 32 partners 12 of them representing farmers and advisors
genomics and biogeography of physalideae solanaceae integration of molecules morphology and fossils to resolve the evolutionary history of the physaloids

the nightshade family solanaceae at once illustrates the common challenges of molecular dating and presents a prime opportunity for expanding knowledge of biogeography and evolutionary history its most widely diverse tribe physalideae contains roughly 300 species mostly distributed in south america half of them with fruit key innovations known as the inflated fruiting calyx the same structures are present in the oldest fossils of the family recently discovered in the south of south america reinforcing the idea of this area as the ancestral zone of origin and diversification for solanaceae after decades of molecular phylogenetics and fossil discoveries i aim to introduce an integrative approach to disentangle the evolutionary and biogeographic history of the physaloids in the light of fossils morphology and museum genomics to approach this i will first infer a calibrated totalevidence phylogeny for the physalideae including fossils and extant taxa building on these results i will estimate diversification rates to test whether phenotypic changes in the fruiting calyx inflation affected them finally and also using the calibrated phylogeny i will reconstruct the ancestral areas of distribution of physalideae and i will test whether there is a correlation between the inflated calyx and the macroevolutionary dispersal rates the convergence of genomics paleobotany and evolutionary morphology will allow us to test if the inflation of the fruiting calyx may have spurred the diversification and distribution of physaloids over the americas and across continents shaping the biogeographic patterns we see today
market design and participation comprehensive design for matching markets

market design combines theoretical and empirical methods to design analyze and enhance realworld assignment markets many of these markets involve limited or no monetary transfers civil servants eg teachers daycare placement for children organ allocation for patients and so on these markets often interact with external opportunities or themselves over time for example a patient in need of a kidney may have multiple treatment options families must choose from various childcare alternatives or public school teachers may request multiple transfers throughout their careers however we have a limited knowledge about how these multiple opportunities interact with the assignment procedure incorporating such options into the design of these markets is challenging due to data limitations as well as the complexity of the modelsthe madpart project aims to address these challenges by understanding and improving the design of assignment markets in the presence of outside options it has two primary objectives 1 investigating how outside options discourage market participation and undermine policy objectives specifically exploring how participationblind procedures contribute to these losses 2 identifying novel and innovative designs that enhance the functioning of these markets this will be achieved through the combination of advanced theoretical models and cuttingedge empirical methods the project will leverage unique and novel datasets from four assignment markets the allocation of public school teachers to schools children to public daycares kidneys to patients and social housing allocation these markets exhibit dynamic interactions with external optionsthe outcomes of the project will give a more comprehensive and deeper understanding of assignment markets and potentially lead to significant policy innovations
remlp recycling multilayer plastic

there is an urgent need for solutions to tackle singleuse plastic waste called multilayer plastic mlp while mlp are extremely valuable packaging materials there is currently no mainstream technically and economically viable solution for recycling them fych has developed a patentprotected groundbreaking recycling process to recycle mlp remlp and recover the full value of their polymers by removing inks adhesives odours and other contaminants to date remlp can process 100 kgday of the 10 most common postconsumer and industrial mlp waste the success of our prototype plant has already brought in early adopters like formaspack and attracted the interest of plastic recyclers who are struggling to process an overload of nonrecyclable plastics and plastic converters who are demanding highquality recycled plastic materials we plan to commercialize remlp through direct turnkey plant sales 15mplant while also generating revenue from royalties of recycled polymers the supply of customized delaminating reagents and technical assistance for plant operation we are requesting 23m in grant from the eic to optimize the industrial process over 12 months to ensure the consistent recycling of 500kghour and obtaining food contact material approval of the recycled output this milestone will pave the way to becoming an international reference in the plastic recycling industry we are also requesting 45m in equity 50 coinvestment between eic and private investorto bring remlp to a fully industrial scale of 1000 kghour trl9 and leverage a future series a from new shareholders for scaleup this project will make 19 industrial remlp plants operational by 2029 thus avoiding 25080 tonnes of plastics ending up in illegal dumping grounds 72960 tonnes from leaking into the environment the emission of 11000 tonnes of co2 associated to the incineration of nonrecyclable waste and 80927 tonnes associated with landfilling
subaltern workers labour relations and empire building in the portuguese estado da ndia 15101663

how and to what extent did free and unfree noneuropean labour contributed to build and sustain the portuguese asian empire during the 16th and 17th centuries this is the main question i will address in this project by exploring the case study of the estado da ndia henceforth ei between 1510 and 1663 the main hypothesis i want to test is that the ei was able to develop and sustain itself even in times of decline due to a highly intensive extraction and allocation of noneuropean labour especially when compared with other european counterparts in the indian ocean namely the dutch and the english this project dialogues therefore with a wider trend in the historiography that analyses the importance of the populations under european imperial dominion for empire building and economic development especially in what concerns noneuropean capital natural resources and labour the allocation of labour in colonial settings was noticeable in many dimensions of the everyday life this project will focus on three intertwined locus of observation the military the urban and the rural labour markets by gathering evidence from european and asian archives building and testing a dataset on occupational structures and labour relations in the portuguese ei empirelab will offer a first insight in labour dynamics in portuguese asia the findings of empirelab will provide historians of the european and noneuropean empires with comparative data and an innovative perspectivein order to feed larger debates both in academic and nonacademic contexts regarding the impact of colonialism in our societies it will raise awareness about labour and migration in historical perspective thus helping to overcome established preconceptions about the relevance of labour for imperial history moreover it will contribute to an improved assessment of the origins and maintenance of inequalities in the early modern colonial period
environmental gentrification and emerging collectives in uncertain times

in the global north in the face of the looming threats of manifold environmental crises there is an increasing sense of urgency to enhance cities sustainability yet topdown paradigms of urban regeneration can contribute creating enclaves of environmental privilege thereby excluding lower income and minority groups from their benefits much recent scholarly debate has focused on the multiple effects of evictions and displacements as well as on active practices of resistance but what happens if after years of protests grassroots groups become the main actors in processes of collective reappropriation and management of urban spacestakeback is an anthropological study of emerging forms of collective care at a moment where the interlocking crises of capitalism democracy and the environment have become more apparent than ever before it follows a comparative case study design through the analysis of different urban mobilizations focused on the collective reappropriation andor use of exindustrial areas in north america montreal canada and europe turin italy it is based on indepth ethnographic research which will include the analysis and production of visual materials by exploring evolving practices and understandings of care within activism takeback will contribute to debates on the shifting meanings of urban citizenship in an increasingly vulnerable worldthe project will be based at polytechnic of turin with an outgoing phase at concordia university montreal takeback will allow me to gain new knowledge in the areas of urban geography and visual ethnography to combine this with my previous expertise in political anthropology and ethnographic research and it will act as a pilot for my own erc starting grant ultimately the project will expand theoretical and practical knowledge about grassroots solutions to the challenge of building more equal and sustainable urban environments
the first multimessenger detection of a supermassive black hole binary

supermassive black hole binaries smbhbs are a natural outcome of galaxy mergers they can be identified as quasars with periodic variability in timedomain surveys or from strong gravitational waves gws by pulsar timing arrays ptas making them exceptional multimessenger sources despite their expected ubiquity they have remained undetected but upcoming data of unprecedented quantity and quality from the legacy survey of space and time lsst and increasingly more sensitive ptas will bring these multimessenger monsters mmmonsters within reachmmmonsters at the intersection of astronomy and data science is an ambitious program to deliver the first multimessenger detection of a smbhb leveraging existing timedomain data we will improve smbhb searches advancing our understanding of binary signals and quasar noise for the first time we will search for more complex and likely more common nonsinusoidal periodicity using the lsst data previews i will develop novel machine learning tools to capitalize on the lsst dataset with advance preparation mmmonsters will be poised to reliably detect binaries in the first few lsst data releases making the project extremely timely and impactfulon the gw side i will pave the way for the first pta detection of an individually resolvable binary i will build novel pta detection pipelines that directly incorporate em data from a catalog of 20 million galaxies which we will compile including all the potential binary hosts my approach will accelerate the first detection of a smbhb and allow the subsequent identification of the binary host galaxy i will forge the ultimate boost in binary detectability through the joint analysis of time domain and pta data in a multimessenger data streammmmonsters will establish strong eu leadership in timedomain astronomy and gw physics through groundbreaking results and by training early career scientists in the emerging field of multimessenger astrophysics
quantumbased cybersecurity protocols

the internet is a ubiquitous technologywith many tasks in private and business lives now achieved online still the networks remain vulnerable to malicious agents and the number of cybersecurity attacks is on the risea trend that will likely continue with the advent of more powerful computersat levelquantum srl an earlyage deeptech innovative startup we deliver an unprecedented level of security provided by our 4th generation quantum key distribution protocol which is physically and mathematically safe against all possible attacks we can become one of the first companies to bring quantum cryptography systems suitable for longdistance fiber and satellitebased quantum key distribution of absolute security to the broader market our solution can secure the networks today and in the future when quantum computers reach their longpromised unprecedented powerin this project we aim to update our business plan conduct market customer research and build a strategy for growth for a diverse and genderinclusive stem workplace in quantum technologies taken together combining the development results of this project with our superior technology will help our company to contribute to the eus digital economy