Dragon09/odtu_chatbot huggingface dataset:
metalorganic framework fieldeffect transistor arrays for chemical sensing

detecting volatile organic compounds vocs at low concentrations is an important but challenging task with a range of applications including checking food freshness monitoring indoor air quality and diagnosing lung conditions through breath analysis in all of these areas highperformance yet compact voc sensors are needed while compact voc sensors exist they suffer from limited lifetimes and low selectivities and often produce questionable data metalorganic frameworks mofs with pores of molecular dimensions are excellent materials to adsorb voc analytes from air even at very low concentrations the moffet project targets the integration of mofs with transistor technology to realize a novel type of voc sensor in addition the modular nature of mofs and microfabrication will be combined to realize an electronic nose demonstrator for the selective detection in mixtures of vocs if successful the project will contribute to novel noninvasive medical diagnostics checking food freshness and monitoring air quality
bioorthogonal implantable iontronic switch to temporally control the local release of chemotherapeutics

our vision for a new type of cancer treatment is based on an implantable therapeutic system capable of programmable ondemand delivery of drugs directly to the tumor we conceive an implantable iontronic switch bioswitch to enable a spatiotemporally controlled administration of highly potent chemotherapeutics without the need for systemic administration of prodrugs or drug conjugatesthis radically new technology will be realized by a combination of nextlevel tools as a result bioswitch can generate previously unobtainable discrete as well as continuous drug concentration profiles at the tumor site and thus allows for the use of highly potent drugs that are otherwise not applicable due to high cytotoxicity the goal is to demonstrate the technologys potential to effectively interfere with tumor progression using a xenograft pancreas cancer mouse model efficiently shrinking tumors in size allows for surgical resection of previously nonoperable tumors and dramatically increases survival ratesour consortium of world leading academics and pioneering smes will ensure the translation of this disruptive technology into the market to maximize the socioeconomic impact
an innovative forest and trees toolkit for reducing malnutrition in africa

malnutrition affects one in three people across the world and is the number one risk factor in the global burden of diseases inadequate intake of fruits and vegetables is a key component of low quality diets especially in subsaharan africa trees are a source of nutrientrich fruits and leafy vegetables and research shows that one promising solution to africas malnutrition problem is to increase the planting of trees that provide nutritious fruits and vegetables currently many countries in subsaharan africa are adopting largescale tree planting programs as a climate mitigation strategy and to improve local livelihoods as such trees can provide a triplewin solution for nutrition conservation and climate goals however the agencies and ngos implementing these treeplanting programs often lack the necessary research and knowledge on which species to plant to maximize benefits for both the environment and people here we will develop a forest and trees toolkit that can be used by extension workers and ngos to make more targeted tree planting programs that also optimize peoples nutrition thereby creating triplewin outcomes for nutrition conservation and climate goals the toolkit will consist of 1 a knowledge platform hosting information on nutritionally important tree species across areas and contexts 2 an app to generate tree species portfolios adapted to local contexts and 3 a user manual on how to use the app including information on how to do live tree portfolio demonstration plots in community areas so that farmers can adopt the trees on their own farms in short the toolkit will be able to identify locationspecific combinations of tree species that address monthonmonth harvest fruits and vegetables and micronutrient gaps in local households diets the development of the toolkit will be based on a unique high quality interdisciplinary dataset that we have collected and compiled during the erc project forestdiet
beyond mapping of the human brain causal deconstruction of brain mechanisms underlying complex social behaviors

social information pervades every aspect of our lives and our ability to process it and respond appropriately is essential to our success as individuals and of society as a whole despite its critical importance there are profound individual differences in social processing abilities the key to understanding this variance may lie beyond isolated cortical regions in the poorly understood largescale interactions between different cortical networks which facilitate the integration of information and the execution of complex tasks we propose a novel framework designed to introduce new tools to the study of some of the most fundamental questions in social neuroscience are there dedicated brain mechanisms for the processing of social information what goes wrong in social information processing disorders and how does social information processing relate to social anxiety do these abilities fluctuate over long time scales years can we predict their change we will create new behavioral tasks to tease apart social task elements and objectively estimate individual social processing abilities using our innovative measure of typicality we will quantify individual differences in performance on social tasks and identify the variance in neural activity which predicts them from a wide range of network features at the high resolution of ultrahigh field 7 tesla fmri this will yield testable hypotheses about the links between networks and social behavior finally and most crucially to test these hypotheses we will use covert neurofeedback a cuttingedge technique which i have been developing to perturb the networks establishing their causal contribution to behavior the combination of novel behavioral neurocomputational and above all perturbation tools for testing causality will provide insights which will profoundly impact our understanding of social information processing in health and advance the reality of personalized treatment of social disorders
nidovirus replication complexes how enzymes shape viral genomes

nidoviruses are an intriguing group of rna viruses whose diverse genome sizes 1141 kb reflect a long history of adaptation to suit specific niches they remain mostly neglected with the exception of the largegenome coronaviridae cov family 32 kb which includes the notorious human pathogen sarscov2 at the other end of the sizespectrum is the smallgenome arteriviridae arv family 11 kb an understudied group of prevalent animalinfecting pathogens viral replication is mediated by a suite of enzymes known as the replication transcription complex rtc at the core of which is the rnadependent rna polymerase rdrp and its unique nterminal domain known as the niran nidorep aims to bridge the prevalent knowledgegap between small and large genome nidoviruses by deciphering the specific structural and mechanistic features of the rtc that regulate genome replication across such vastly different viruses it will be divided into three distinct objectives objective 1 will focus on smallgenome nidoviruses providing the first structural and functional characterization of an arv rtc objective 2 will probe how rdrp speed and fidelity have been finetuned to accommodate the distinct and conflicting replication requirements of diverse nidoviruses this will be achieved through the development of an innovative in vitro sequencing assay also providing a new and robust tool for screening drugs that corrupt rna synthesis objective 3 will investigate the role of the niran in initiation of rna synthesis though proteinpriming providing new insight into the functional evolution of this complex domain while also identifying novel drugtargeting sites nidorep will determine how specific viral enzymes have structurally and functionally evolved to support remarkable genome diversification within a single viral order it will expand our understanding of understudied viruses with epidemic potential and guide drug design strategies against key viral targets
ecology of wildlife livestock human and infectious diseases in changing environments

wilimanid addresses the complexity and the dynamics of the hostpathogen interactions for five animal infectious diseases ids that are ranked as high priority by the eu avian influenza african swine fever west nile fever african horse sickness and chronic wasting disease these ids circulate in livestock and wildlife and at the humananimal interfaces two are causing severe economic losses to farming systems and three represent a threat to human health the main objective of wilimanid is to identify key factors driving their emergence and dissemination in everchanging environments by integrating data at different scales pathogenshostcommunity of hoststerritory and to provide farmers health services and policy makers with innovative strategies and methods for prevention surveillance and control for the ids considered in wilimanid and beyondto meet this objective wilimanid will in particular improve methods for sensitive and accurate detection and identification of pathogens and their variants in complex environments identify drivers promoting the increase in pathogen virulence transmissibility andor hostshift assess the impact of host factors as a key parameter of pathogen evolution and dynamics such as vaccination or preexisting immunity to viral infection identify transmission routes the role of vectors the impact of the environment pathogen reservoirs in wildlife global change impact on migration routes and of the management practices farming trade transport on pathogen dissemination and transmission develop nextgeneration analytical approaches for optimized surveillance and management strategies of ids within a context of global changes disseminate and communicate the results to stakeholders and engage in further coinnovation convert the results into user guides training materials and communication tool kits to optimise their exploitation
supporting architectural and technological network evolutions through an intelligent secured and twinning enabled open experimentation facility

the 6gsandbox project brings a complete and modular facility for the european experimentation ecosystem in line and under the directions set by sns ju which is expected to support for the next decade technology and research validation processes needed in the pathway towards 6g the target is at technologies and research advances that span over the entire service provisioning chain and refer to userdata control and management planes in this direction 6gsandbox introduces the concept of trial networks which refers to fully configurable manageable and controlled endtoend networks composed of both digital and physical nodes the 6gsandbox trial networks incorporate infrastructures distributed in eu namely in malaga athens berlin and oulu and offer to third parties including experimenters from open calls automated experimentation capabilities through a rich and extensible toolbox meant to create tangible and longterm impact the 6g kpis and kvis that will be quantified with the facility will be released to any interested party while the set of developments and apis that will be produced will feed an open repository as an initial step to move the contributions and the lessons learned beyond the project boarders and define a european 6g library
microglia as controller of brain metabolism during aging

microglia represent the main brain residential immune cells in the last years evidence emerged that besides representing the first line of defense against pathogenic insults microglia are also centrally involved in physiological functions essential for correct cns development and function microglia in a spatially and temporally controlled manner influence neuronal apoptosis neurogenesis and myelin formation and manage synapse homeostasis including removing supernumerary synapses during development these widely heterogeneous roles are supported by distinct subtypes or states of microglia present in different regions of the brain and at different times during cns development in the last years triggering receptor expressed on myeloid cells 2 trem2 emerged as a key gene which controls the microglial metabolic state in addition to directing synapse elimination and shaping the functional brain connectivity in the present project i propose that microglia via trem2 direct the genetic signature of specific subgroups of brain cells shifting them toward specific metabolic and developmental patterns i hypothesize that this mechanism is key for the control of metabolism in the hypothalamus where the neuronal contingents orchestrating systemic energy homeostasis reside by using a combination of transcriptomics multiplex protein expression analysis and cellbased imaging methods i will determine which subsets of microglia cooperate within hypothalamic centers and will define the underlying mechanisms i will also assess whether defects in this orchestrated crosstalk affect the central regulation of energy and glucose homeostasis during aging data from this study will provide comprehensive knowledge of microglia functions in shaping hypothalamic complexity and endocrine output also they will offer a targeting potential for new therapeutic strategies that could reverse immunometabolic dysfunction by modulation of hypothalamic microglial function
the racialized leviathan a history of state personifications from hobbes to sarmiento

political thought has always been permeated by personifications a personification is the graphic or rhetorical representation of an abstract idea as a person thanks to the device of personification notions like liberty power the state and the nation acquire concrete form as characters in a narrative of reallife events thomas hobbes leviathan and frances marianne are preeminent models of european state personifications these figures expressed an idea of order and civilization in opposition to a common counterpart savage america but what if america resisted this characterization my research delves into that question it develops a genealogy of the conceptual pair orderdisorder expressed through personifications of europe and america from the 17th to the mid19th centuries furthermore it innovates by examining an underexplored subject the original disruption of this opposition by the argentine thinker domingo sarmiento he constructed a personification of the argentine state that displayed a highly efficient political order which i term a racialized leviathan this project primarily adopts the methodology of conceptual history interpreting texts symbols and concepts related to these personifications within their intellectual and historical contexts it also incorporates insights from postcolonial studies in addition it draws on approaches from literary studies and art theory to elaborate a formal definition of the concept of personification and to explore the way in which works of art articulate ideas the main breakthroughs of this project are a a pioneering historicization of state personifications hitherto mostly studied in its european formats but overlooked in its latin american reception
linking and quantifying the impacts of climate change on inland ice snow cover and permafrost on water resources and society in vulnerable regions

recognising the central role played by snow ice and permafrost in the global climate system the liquidice project joins expert cryospheric observers and modellers to i comprehensively reassess the past and future centuryplus of climateinduced high impact changes to the greenland ice sheet and climate vulnerable locations across the alps norway high mountain asia hma and svalbard including permafrost areas and their ecosystems ii develop new expanded and harmonised data from satellite earth observation eo and ground stations iii use these data to improve and test a hierarchy of ice sheet and glacier models with earth system models esms iv through these steps yield new process understanding and ultimately v inform water resource hydropower and socioeconomic strategies through clear and transparent communication of results and uncertainties the projects strengths lie in new multidisciplinary collaborations across 18 research institutions from eight european countries poland italy denmark germany spain sweden norway united kingdom and india encompassing expertise in field observations satellite eo techniques esm development and application and socioeconomic analysis key deliverables include a fairprincipled new multidecade data catalogues of multiregional snow water equivalent and a 44year eoderived albedo record b assessments of impact of model resolution and degree of coupling on results c refined past and future glacier ice cap and greenland ice sheet freshwater fluxes to oceans and global sea level rise with indirect constraint on antarctica d new hydrological simulations for hma e a new framework for a water discharge impact assessments f socioeconomic integrated risk and adaptation assessments g all with comprehensive dissemination and communication outputs ultimately by advancing snow and ice climate assessment liquidice advances eu efforts toward resilience to high impact climate changes
unravelling the behavioural mechanisms underlying the evolution of disassortative mating

understanding the origins and mechanisms of biological diversity is a central aim of evolutionary ecology mating behaviours contribute to shaping diversity because of their importance in determining the genotypic composition of populations and the association among adaptive traits interestingly recent work shows that disassortative mating the tendency of dissimilar individuals to mate together may stably maintain character diversity within populations examples include traits showing heterozygote advantage like immunity genes yet little is known about the behavioural and genetic basis of disassortative mating linked to traits under balancing selection the proposed project will fill in this knowledge gap by utilizing the polymorphism in predator warning colour patterns in a butterfly as a model to study disassortative mating at a locus under heterozygote advantage in particular i will examine the role of male mating cues on female preference test theoretical predictions of the evolution of disassortative mating and assess if disassortative mating may be modulated by females experience my results will provide novel mechanistic insights into this behaviour and improve our understanding of how interactions between behavioural ecological and genetic factors can shape diversity this project will use a novel and multidisciplinary approach that combines behavioural experiments chemical analyses and electrophysiology of mate cues with genetics to investigate the behavioural and genetic basis of disassortative mating unprecedented detail i will acquire new skills and knowledge in evolutionary biology and genetics that complement my background in behaviour and cognition in return i will share my expertise in topics different from the research done at the host institution which will certainly spark new research ideas and collaborations
law enforcement mobilities across borders

the project law enforcement mobilities across borders lemobab investigates how practices of crossborder police cooperation cbpc contribute to the production of a legal and political european space its overall aim is to connect bottomup insights from selected borderregions with ongoing legislative developments on eu level aimed at enhancing police cooperation in particular the upcoming proposal for a new regulation the police cooperation code three questions lead this research 1 empirically what are the relations and variables between situated bilateral cbpc and the role of legalgeopolitical practice in fostering security cooperation conceptually what role do le mobilities and borderregions play in the creation of a european space and applied how can qualitative police and securityresearchs understanding of complex social legal and political dynamics increase its impact the focus upon le mobilities cbpc as spatiallegal practice enables to contribute filling three gaps 1 at scholarly and policy level an empirical research research gap 2 at the intersection between social and legal policecooperation scholarship and critical security and eu studies the need for spaceandpractice sensitive concepts of lawmaking and of lawenforcement 3 in public scholarship the underused potential of academic knowledge visualisation for increased impact this study will produce empirical results accompanied by empirically grounded practiceoriented and spacesensitive concepts regarding a delicate but core element along the process of european integration the exercise of executive powers beyond national jurisdiction results will provide critical understanding of legal frameworks and of social practices which are of relevance to he cluster iii and contemporary eu policy objectives the innovative pf design will foster a creative and innovate researcher profile visual communication will enhance the projects scientific and public impact
aidriven multiscale methodology to develop transparent wood as sustainable functional material

aitranspwood ambition is to create an aidriven multiscale methodology for new safe and sustainable by design ssbd and functional woodbased composites and demonstrate the concept for transparent wood tw a promising composite with potential applications in several industrial fields such as construction automotive electronics and furniture by developing ai supported ssbd framework for tw we contribute to european green deal by providing innovative sustainable materials and costeffective tools for european industries paving the way towards green and sustainable transition ssbd tools used by the chemicals and materials community with new transparent wood materials increases the innovation capacity of smes and industry for future sustainable productswith the help of aitools and advanced experiments we develop multiscale models from the atomistic scale to continuum for the manufacturing process and the mechanics of the transparent wood allowing for virtual screening of biosourced alternatives for hazardous and petrochemicalbased chemicals required for manufacturing transparent wood using the current solutions the built computational models are openly shared within the european environment for scientific software eessi the userfriendly surrogate model is also made available in the vtt modeling factory environment along with an lca tool for industrial use four tw business cases are conducted with the aim to be commercialized in the construction automotive electronics and furniture industries the ssbd framework will guide the whole creation of the tw products providing a competitive advantage to the european manufacturers interested in introducing the tw composites in the european market also as substitutes of glass and plastic in various applications this can considerably increase the european share in the global production of sustainable tw composites