Dragon09/odtu_chatbot huggingface dataset:
effect of ph on colloidal structures in human intestinal fluids and intestinal absorption of anticancer drugs

oral administration followed by intestinal absorption is the preferred way to deliver drugs to the body therefore estimating thecorrect oral dose to achieve a therapeutic effect is an important challenge when developing drug products predicting intestinal drugabsorption needs to consider multiple influencing factors including properties of the drug the formulation and the human intestinalfluids hif one of the critical factors of hif is ph as it may influence intestinal drug absorption both directly and indirectly the directeffect of ph on a drugs ionisation state and subsequently intestinal absorption is widely known however the effect of ph on thesolubilisation and absorption of lipophilic drugs by changing the colloidal structures present in hif has not yet been systematicallyanalysedunderstanding this indirect ph effect is especially needed to improve dose predictions for drugs with a narrow therapeutic windowsuch as anticancer drugs and address both inefficiency and potential side effects the proposed project therefore aims to understandand predict the ph effect on colloidal structures in hif and how it affects the absorption potential of anticancer drugs in both fastedand fed state conditionsto achieve its goal the project combines the expertise of the host group at ku leuven in absorption profiling using in vitro and invivo methods with the applicants experience in predictive in silico modelling this approach will provide unique insights into theindirect ph effect on drug absorption and contribute to the development of in silico predictive models to guide the earlystageformulation and dose optimisation of anticancer drugs as such the project will have important value for pipelining new anticancerdrugs and will benefit the european commission priorities for 20192024 such as the pharmaceutical strategy and europes beatingcancer plan
envisioning an integrated quadruple helix and rri framework for food system transformation and regional innovation ecosystem enhancement

vision4food aims to enhance the sustainability and resilience of eu food systems through the development of innovative governance models that contribute to better informed decisionmaking processes while promoting social engagement and innovation in 5 european regions finland spain italy greece poland with different innovation ecosystem maturity levels through the project our regions will be supported to strengthen their role in the creation of food innovation platforms fips fostering collaboration among quadruple helix stakeholders and facilitating the identification and scaling of innovations for food system transformation the methodology involves cocreating ri strategies emphasizing open science and responsible research innovation rri through vision4food multistakeholder approach and the integration of tools and services we will provide them all the necessary support for knowledge exchange networking and priority setting in the form of an acceleration agenda tailored to each regions priorities and needs while facilitating the transition to an innovative and inclusive food system we will closely monitor and evaluate the performance of the governance models operation providing evidence of its impacts
advanced 3d in vitro models based on magneticallydriven docking of modular microscaffolds

this project is focused on the design the production the characterization and the proposal for future commercialization of 3d modular coculture systems specifically designed to recapitulate the physiopathological microenvironment of brain tumor the key technology at the base of the proposed project is the design of magnetic microscaffolds and their fabrication through twophoton polymerization 2pp a disruptive mesoscale manufacturing technique that enables lowcost obtainment of microstructures with nanometric resolution characterized by unprecedented levels of accuracy and reproducibility a microtubular structure scaffolding endothelial cells and connected to a fluidic system will be exploited to mimic the bloodbrain barrier this biohybrid device will be the base for the assembly of ferromagnetic microcages hosting glioblastoma cells and will be provided with docking systems for superparamagnetic microcages carrying undifferentiated and differentiated neuronal progenitor cells this approach represents a disruptive innovation with respect to other 3d models available in the literature as it will allow a faithful recapitulation of the complex glioblastoma microenvironment through a platform that can be very easily handled in any laboratory highthroughput screenings of brain drugs and in vitro testing of the efficacy of different anticancer therapies are envisaged upon successful accomplishment of the project leading to a pioneering generation of flexible multicellular platforms easily adaptable to the mimicry of different pathological conditions
4d braintargeting nanomedicines for treating neurodegeneration

aging aging genetic and environmental factors have increased the prevalence of patients with neurodegenerative brain conditions with limited treatment modalities one prerequisite for effective brain treatments is the ability to target nextgeneration medications including rna and protein drugs to specific neurons and brain regions nanotechnology platforms offer new therapeutic avenues for targeting drugs to organs and cells their implementation in neurodegenerative diseases is nascent in this research program we aim to advance far beyond the stateoftheart and elucidate the molecular and structural characteristics for designing nanotechnology drugs that target and treat brain neurodegeneration in preliminary studies we show that the bloodbrainbarrier bbb overexpresses diseasespecific receptors during neurodegeneration which enable targeted nanoparticles to cross the bbb and penetrate neurons albeit these findings the magnitude mechanism and nanotechnological molecular pattern for brain targeting are lacking to address this fundamental gap we will use advanced computation and engineering concepts to develop 4dbraintargeting nanoparticles that cross the bbb intact to target specific neuronal populations and brain regions robotic synthesis coupled with active learning algorithms will be used to construct nanoparticles with combinations of targeting moieties on their surface and evaluate their neuronal specificity supported microfluidic bbb apparatus will be used to screen the nanoparticles ability to target and cross the bbb a trackandseek radar system will locate the nanoparticles in the brain directing localized robotic biopsy of the nanoparticles in the destination cells in the brain to connect our findings to future clinical implementation fmri will be used to record the therapeutic activity of the nanoparticles in the brain this program will provide the community with essential findings to allow braintargeted therapeutics
spatiotemporal characterization of extrachromosomal dna transcription and its key regulators in cancer cells

extrachromosomal circular dna ecdna present in cancer cells stochastically amplifies oncogenes and drug resistance genes independent from the core genome and thereby contributes to tumor adaptability and heterogeneity while ecdna prevalence diversity and biological traits have been studied we lack insights into their expression regulation it is unclear how it differs from chromosomal genes and how it is linked to the nonrandom and dynamic nuclear localization patterns observed for many ecdna moreover we are unaware of the proteins that participate in interactions with nuclear compartments to control ecdna transcription most studies using sequencing and fish methods fall short in describing these dynamic processes however understanding their implications is vital for designing therapies that target ecdna expression as a whole instead of targeting individual oncogenes to advance our knowledge we need tools to map ecdna transcription at high temporal and spatial resolution and systematic methods to screen for associated proteins the aim of this project is to identify crucial overarching mechanisms and players of ecdna transcription through an interdisciplinary approach the medema group has devised protocols to induce extrachromosomal amplification of drug resistance genes in diverse cellular backgrounds and genetically tag them for imaging and perturbation the present study will build on this work to for the first time reveal the spatiotemporal coregulation of ecdna transcription and localization using innovative imaging reporters for measurements in single live cells and use unbiased proteomic profiling to map factors that interact with ecdna and regulate their expression besides addressing outstanding questions in the field our study will create unique cell models and datasets as a basis for future studies our results will furthermore inform the design of more effective treatments for the many cancer patients affected in europe and worldwide
mitochondrial strategies in ferroptotic cell death

mitochondria serve as the epicenter of cellular metabolism their dynamic communication with other compartments within the cell ensures proper cellular function my recent work reveals how mitochondria communicate with the plasma membrane pm to transport a redoxactive lipid coenzyme q ubiquinone or coq this communication is crucial for inhibiting a form of ironmediated cell death called ferroptosis notably coq is exclusively synthesized within the mitochondria and plays a pivotal role in maintaining the mitochondrial respiratory chain as well as other metabolic pathways such as pyrimidine synthesis fatty acid oxidation and proline metabolism my work highlights that cellular defense is primarily orchestrated from the mitochondria and surprisingly dependent on a moleculecoqthat is indispensable for mitochondrial function this work shows that mitochondriaknown as cell death inducersprotect cells from ferroptosis and opens several key questions that i will address in mitoferroquest including i which proteins and metabolic pathways within the mitochondria dictate whether coq should be exported or retained within the mitochondria ii do mitochondria have other ways to defend against ferroptosis or is coq export their only defenseiii does mitochondrial communication extend beyond the pm and involve interactions with other organelles such as the endoplasmic reticulum er in protecting cells against ferroptosisanswers to these questions will enhance our understanding of mitochondrial strategies in ferroptosis potentially paving the way for new therapies in conditions where ferroptosis is implicated like neurodegenerative disorders mitoferroquest sets the stage for my overarching goal of exploring ferroptosis in diseases with compromised mitochondrial function such as leigh syndrome with the aim to assess its potential as a therapeutic target
nanooxygenation in water treatment by ambientpressure airfed ultralowenergy nanobubble generation

spun out of ucd chemical engineering aquabs ambitious mission is to no less than clean up the worlds water the intellectual machinery embedded in our nanobubblegeneration and controlled release this is based on an electricfieldinducing electrostriction which serves to create a transient negativepressure region thereby sucking in gas into the liquid in the form of many nanobubbles which are kinetically metastable typically for many weeks and longer the energy costs of this additivefree noncontact method are an order of magnitude lower than classical approaches eg involving massive pressure drops from pumping across venturi tubes etc with a far longer lifetime and smaller more uniform size range in this project we will revolutionise the lowenergy and lowmaintenance aeration of water the novel nb generator will be tested in three use cases wastewater treatment aquaculture and agriculture and prepared for full commercialisation
fibrebased plasmonic micro reactor for flow chemistry

major challenges of the european and worldwide society such as the climate crisis insufficient environmental protection food and pharmaceutical shortages and military aggressions require technologies that substitute fossil fuels with sustainable energy sources in basically all industries following the green deal of the eu commission the european continent shall become the first climateneutral continent by 2050 the chemical industry is a major contributor to co2 emissions as it accounts for about 30 of the industrys total energy use worldwide even though socalled photochemistry promises to sustainably produce chemical compounds by sunlight corresponding reactors suffer from insufficient light management even in modern micro flow reactors which hinders their upscaling to applications in industry this is exactly where the key to the technological and economic breakthrough lies and this is where reactor comes into play it will contribute to the ambitious goal of a sustainable chemistry by developing and validating a novel type of lightdriven chemical reactor with enormous scaleup potential for industrial applications it will be based on an interdisciplinary and innovative technological approach combining optical fibres for smart light management metallic nanoparticles as efficient energy transmitters nano and microfabrication for microfluidic functionalization as well as monolithic optical integration and flow chemistry as an ecofriendly and safe chemical technology for the first time a demonstrator of the novel reactor architecture will be setup and benchmarked with relevant photochemical reactions ultimately the proposed fibrebased microfluidic reactors will enable implementation of new and efficient routes driven by light to prepare pharmaceuticals agrochemicals and materials on both lab and industrial scales
quantitative analysis for modern signal processing

cell phones digital cameras medical imaging and environmental monitoring signal processing is at the core of our modern world motivated by the emergence of telecommunications in the 1960s mathematical signal processing succeeded in providing a theoretical framework for the digital transmission of analog data in communication systems however as new technologies and applications arrived much of the existing theory falls short of providing a sufficient formal description to support them this project contributes to the development of mathematical theory and formal descriptions of many modern signal processing applications that are to date merely heuristically validated my specific objectives are the following 1 quantitative analysis of sampling schemes where measurements are collected over continuous trajectories and signals evolve in time during the measuring process combining different aspects from the theory of mobile sampling and dynamical sampling 2 advances in the method of sampling with derivatives hermite sampling to integrate modern signal setups modeled by shiftinvariant spaces through exploring new connections with shiftpreserving operators theory 3 quantification of existential results concerning sampling and interpolation with quasicrystals to explicitly estimate stability marginsduring my phd i worked on harmonic analysis and sampling theory including the topics of exponential bases shiftpreserving operators and dynamical sampling many of the methods i developed will be applied in this project complementarily my supervisor jose luis romero is an expert on sampling in shiftinvariant spaces mobile sampling and quantitative sampling theory working at univie the academic house of many experts in these fields i will benefit from the perfect environment to successfully develop my objectives
monitoring reporting and verification of soil organic carbon and greenhouse gas balance

mrv4soc aims at designing a comprehensive robust and costeffective tier 3 approach accounting for changes in as many c pools as possible to estimate ghg and full c budgets coupling c and n cycles quantify soil organic carbon soc accumulation and assess the results of traditional management practices and c farming the main challenges addressed in mrv4soc are i monitoring changes in soc accumulation due to climate change and socioeconomic pressures ii accounting for c and n cycles in full c budgets iii development of scientificallysound standard and transparent tier 3 methodology at different scales iv implementation of highquality insitu and rs data for testing methods and scaleup purposes iv standardisation of monitoring reporting and verification schemes to ensure transparency robustness and costeffectiveness and v a lack of trust in voluntary carbon markets to overcome these challenges mrv4soc will develop 6 specific objectives which will be measurable verifiable and monitored through kpis pointing at specific targets mrv4soc proposes a comprehensive 3year work plan that ranges from the assessment of c pools in 9 land use land cover classes located in 14 demonstration sites ds to the potential integration of the approacmrv4soc aims at designing a comprehensive and robust tier 3 approach accounting for changes in as many c pools as possible aboveground biomass below groundbiomass litter dead wood soil organic carbon and harvested wood products fully aligned with national ghg reporting mrv4soc seeks to develop solutions applicable for different spatio temporal scales and climate change scenarios and validated for a wide variety of ecosystems in arid temperate and continental climate zones in collaboration with local stakeholders the proposed approach will help establish reliable and transparent c farming credits within a costeffective monitoring reporting and verification mrv methodological framework
utilizing iotsystems for decentralized production control and offering surplus production capacities on a production platform

assemblean is an automation and production technology company emerging from years of research in the field of decentralized production control xiaojun yang and alexander pöhler investigated the question of how to increase the utilization of production facilities it became apparent that many production capacities remain unused during this research at the heinz nixdorf institute of the university of paderborn we developed a decentralized production control system with which existing production systems can be equipped these control systems then communicate with each other in order to subsequently take over production control automatically this leads to significant improvements in production processes in addition the production control systems identify free capacities automatically assemblean wants to use these capacities and make them available to other companies for this purpose a productionasaservice platform was also developedwith this ondemand production platform products can be built completely digitally the wide range of production processes and services enables us to offer to handle the entire supply chain of the products from purchasing raw material and standard parts to manufacturing assembly and shippingassemblean has received a grant of 565000 this has been used to develop both products the decentralized production control and the production platform until we founded assemblean gmbh in march of this year xiaojun yang and alexander pöhler cofounded assemblean our startup has grown into an eightperson team four fulltime employees and four student assistants contribute expertise from the fields of mechanical engineering industrial engineering and it both founders have already gained startup experience through starting and building up an ecommerce gmbh operating throughout europe
making sense of the unexpected in the gravitationalwave sky

general relativity gr is more than a century old but is still our best macroscopic description of gravity key gr predictions are black holes bhs and gravitational waves gws whose spectacular confirmation led to two recent physics nobel prizes the future of gw astronomy however is even brighter since detectors will observe bhs at cosmic dawn and probe their enigmatic event horizon where gr clashes with quantum mechanics in the information loss paradox these experiments will measure signals hundreds of times smaller than today necessarily discovering anomalies and deviations from current predictions eg due to the astrophysical environment on the fundamental side precision gw astronomy will open countless possibilities for understanding the standard model of particle physics and its extensions gravity and cosmology by itself however precision is not knowledge to harness the power of these measurements a groundbreaking framework is urgently needed to solve the very nonlinear equations of gr and develop waveform models to unprecedented accuracy and to convert these results into concrete interpretation tools gwsky will leverage the worldleading expertise of its pis in astrophysics gwsource modeling particle physics and gr and recent paradigm shifts to build an overarching framework answering a fundamental question when inevitably an anomaly in a gw signal is identified what is it a gravitational effect not predicted by gr the influence of nearby matter or merely an imprecise calculation of the expected signal even tiny deviations from gr would shake physics to its core but to claim a deviation from it one needs to filter out first the contributions from the astrophysical environment instrumental artifacts and systematic modeling uncertainties gwsky will provide tools to disentangle these contributions enabling precision gw astronomy with upcoming observational runs and new facilities on the ground and in space
european photonic quantum computer

photonics is one of the first platforms explored for quantum computing qc bringing the advantage of low decoherence and natural connectivity for distributed and blind qc recent years have witnessed a stepchange in the scale complexity and scope of qc with photons which recently led to 3 out of the 4 demonstrations of quantum advantage from canadian and chinese groups these impressive achievements were obtained with squeezed light in bulky apparatus that are not fit for scalability europe shows strong leadership in development of integrated optical qc platforms with breakthroughs in the development of high transmission dense photonic chips record efficiency detectors and deterministic single photon sources photonic qc also benefits from a clear roadmap toward fault tolerant architectures proposed by leading eu quantum algorithm teams epique gathers world leaders in photonics qc with expertise in both technology and algorithms from academia and smes who work together to deliver the technological breakthroughs required to push the platform toward general purpose qc this will be achieved via new nanofabrication that combines novel switching with mature silicon compatible circuitry via optimising both single photon sources and detectors via new interfacing possibilities in silicon nitride and direct write modular chips via fast low loss switching in lithium niobate and via quantum architectures that leverage all of these advances epique will develop three qc prototypes that will demonstrate essential building blocks of generating and fusing quantum states to entangle 10 qubits and critical measurement and feedforward capabilities required to scale the platform to 1000 qubits at the end of this project we will have proven a route to general purpose quantum computing that will strengthen private investment in eu based optical qc companies