Dragon09/odtu_chatbot huggingface dataset:
skin microinjector

needlebased injections are very common in modern medicine notably in ongoing vaccination efforts worldwide however needle phobia and infection risks affect patient compliance with medical treatments while millions of used needles contaminate the environment lastly the effectiveness of certain drugs increases when injected intradermally but targeting the dermis is challenging thus new minimalinvasive procedures are needed jet injectors are needlefree medical devices that pressurize thin liquid filaments to penetrate the skin jet injections have been effective in subcutaneous and intramuscular delivery ex vivo and in vivo however the expected needlefree revolution for medical treatments has neither been fulfilled nor widely commercialized due to factors such as a bruising a painful consequence of delivering large volumes in a single location b when using wrong energy settings or misalignment with respect to the skin the injected liquid can perfuse other layers c the rejected liquid splashes back leading to an incorrect dose delivery risks of cross contamination of the injector parts or splashback on the care giver d commercial jet injection methods such as springs or compressed gas are noisy which can distress the patient hence there is a need to develop a new way to deliver smaller doses with maximum accuracy in targeting specific skin layers boldjet is aimed at revolutionizing the experience of people who receive or perform frequent injections by developing for the first time a needlefree device using microjets that is safer minimally invasive and ecofriendly by avoiding the use of needles we can increase adherence to treatments by patients with fear to sharps and expand clinical routes for existing drugs and treatment
use of opensource p2p energy sharing platforms for energy democratization

the u2demo project aims to create innovative consumercentered management strategies that facilitate widespread participation in peertopeer p2p trading and energy sharing this initiative will promote equitable and democratic access to sustainable energy resources the collaboration brings together twenty partners including associated partners from eight countries pooling their expertise to develop strategies that will be seamlessly integrated into opensource nonproprietary tools and platform these solutions align with principles of openness technology neutrality interoperability scalability replicability reliability security and trustworthinessthese strategies will undergo testing within at least four diverse energy communities each characterized by unique attributes and governance models the overarching objective is to assess advanced p2p trading and energy sharing tools determine optimal implementation conditions and consolidate the most promising solutions and associated business modelsthe p2p trading and energy sharing tools will account for existing flexibility services managed by transmission and distribution system operators tsos dsos including both implicit and explicit demand response dr programs as well as dynamic capacity and price signalscontracts the initiative strives to enhance coordination leveraging information exchange through existing dataspaces and middleware decision support algorithms will empower consumers and prosumers to actively engage in energy and flexibility services promoting negotiation and collaboration among peers and stakeholders maximizing their benefitsall interactions offers contracts and coordination within p2p trading and energy sharing tools will adhere to existing and forthcoming standards and will be executed using blockchain this approach ensures the credibility and traceability of all activities conducted in p2p trading ultimately fostering greater consumer engagement
contributions of muscle mechanics and sensorimotor control to agile locomotion

humans and animals navigate complex terrain seemingly effortless this is in stark contrast with even the most performant robots illustrating that walking over complex terrains is by no means trivial our neuromusculoskeletal system is equipped with mechanisms that allow us to recover from unexpected perturbations two key mechanisms are muscle intrinsic mechanics and sensorydriven feedback control immediate changes in muscle force upon a perturbation allow the body to respond fast to sudden perturbations through quickacting muscle mechanical responses feedback responses slower due to transmission delays are also critical to stability as they are more flexible whereas muscle mechanical responses are determined by feedforward control and muscle properties we do not yet know how these pathways interact to help us maintain agility and robustness in the presence of external perturbations or in the case of sensory loss i aim to gain novel insights into how muscle mechanics and sensory feedback allow agile locomotion across conditions i will unravel fundamental principles governing relative contributions of these mechanisms using a blended experimental and computational approach i already collected a unique experimental dataset that i will combine with physicsbased simulations i will use novel approaches to predict locomotion patterns and feedforward and feedback control by optimizing performance criteria in presence of sensorimotor noise without relying on experimental data validation of simulation to experimental data allows us to evaluate which performance criteria and muscle properties drive observed interactions between muscle mechanics tuned by feedforward and feedback control as many neurological disorders impair stable locomotion fundamental insights obtained through my project have potential to inform treatments lastly novel insights in locomotor neuromechanics inspires designs of legged robots and prosthetics to assist during locomotion
multimessenger softfield spectroscopy of molecular electronics at interfaces

the realtime interrogation of molecular electronics at the interface between different media is key to understanding the fundamental mechanisms at the basis of processes such as catalysis solar energy harvesting and charge transport in optoelectronic devices such an investigation ultimately requires attosecond temporal resolution and picometer spatial accuracy to capture in realtime the energy exchanges mediated by the electron wave function and the competing structural changes of the target experimental strongfieldlaser physics has been demonstrated to provide outstanding spectroscopical methods for this purpose such as highharmonic generation spectroscopy attosecond science and laserinduced electron diffraction however it also presents intrinsic limitations such as high peak intensities low efficiency and poor tunability these obstacles have so far hindered its application to the study of highcomplexity systems for example complex interfacessoftmeter aims at filling this gap we are proposing a novel multimessenger twocolor spectroscopy namely softfield spectroscopy that converts the concepts of strongfield physics into the moderate or weak field regime and overcomes its limitations while still providing an unprecedented spatiotemporal resolution the new protocol will be developed in the first phase of the project it is based on an interferometric setup combining fewfs ultraviolet pulses with fewcycle ir pulses and on the multimessenger measurement of the laserinduced electron diffraction and the highharmonic radiation of the target in the second phase of the project the novel softfield scheme will be employed for the realtime interrogation of electronics at molecular interfacessoftmeter will pave the way for a new class of ultrafast laser spectroscopy experiments with a large impact on several disciplines ranging from photochemistry to biology as well as from energetics to environmental science
self assessment protection healing tools for a trustworthy and resilient ccam

selfy will increase ccam ecosystems safety security robustness and resilience by researching and developing a toolbox made of collaborative tools which main pillars are i situational awareness through collaborative perception and monitoring ii data sharing advanced processing for detection of malicious events and decisionmaking iii resilience increased ability to adapt and respond to cyberthreats and cyberattacks and iv trust including guarantees regarding privacy confidentiality integrity and immutability of data in a collaborative ccam environment selfy tools can operate individually andor cooperatively with other tools generating a distributed global solution where selfprotection selfresponse and selfrecovery decisions will be managed locally or globally as appropriate for any given cyberattack malicious activity or hazard extending the operational design domain odd in europe 50 million connected cars are expected in circulation by 2026 and eu regulations requires for cybersecurity certificates for vehicles in this scenario selfy long term impact is grounded on a value proposition that is oem andor vendor agnostic thus facilitating adoption at all stages of the value chain additionally the consortium involves all necessary stakeholders for cocreating a sound and comprehensive ccam solution including oems road operators traffic and infrastructure management researchers and policymakers selfy expected outcomes include 5 traffic and infrastructure management organizations adopting the selfy toolbox which will benefit of a 90 effectiveness rate in detection of vulnerable vehicles and security breaches and an increase of 75 off the mitigation rate at demonstrated in trl6 by the end of the project
selfassembly shifting our view of life

biology invites us to understand life as hard work living beings are mainly viewed as systems requiring the constant input of energy and the detailed regulation by genetic material these ideas of life very much influence the general understanding of living systems and particularly interesting for this project it influences current philosophy of science accounts of the understanding and explanation of living processes but what if life is much less hard work than often presented and what if genes should be understood as nudgers rather than as directing living processes selfassembly is the spontaneous formation of complex patterns and structure it can be visualized as a pile of lego bricks turning into a ninjago fortress on its own there are no legobuilders the parts selfassemble possibly as a result of chemical and physical processes working between and on the parts recent nanoscience research efforts at the intersection of chemistry biology and material science increasingly utilize selfassembly processes in the development of new materials technologies and understanding of living systemsassemblinglife will on an interdisciplinary basis build a new theoretical framework withing the philosophy of science for understanding and explaining life building on the increasing focus and knowledge about selfassembly processes that carry the potential to shift our view of life the project will provide a new understanding of genetic causation starting from the idea of genes as nudging selfassembly processes rather than as providing detailed regulation and it will develop new theory of scientific explanation that will account for the observation that selfassembly processes do not behave like classical mechanisms or interventions targets assemblinglife plan for contributing novel and needed theory and conceptual tools both to the philosophy of science and to the empirical life sciences
realising girls and womens inclusion representation and empowerment

in order to prevent and reverse inequalities and promote girls and womens inclusion representation and empowerment it is necessary to better understand the root causes of gendered power hierarchies and gender gaps across political social economic and cultural spheresrewirings overall objective is to contribute to practical sustainable and structural institutional change in these spheres through evidencebased understanding of cumulative effects of gender stereotyping and multiple forms of discrimination and disadvantagesthe project therefore involves extensive research in six countries including belgium the netherlands spain south africa poland and the uk and collaboration with a variety of stakeholders the project team will carry out a survey and interventions in addition to qualitative data collection media discourse analysis and legal policy analysis rewiring incorporates innovative responses to the challenge to properly identify how the interrelations of power and barriers shape gender inequality and exclusion within the different spheres and how these can be effectively changed it does so first by developing an approach that combines insights from the institutional experiential and symbolic levels of gender inequality in the fields of decisionmaking law and policies work education and media this will provide the basis for a much needed multidisciplinary transformative equality approach this approach will also add to the stateof theart by taking intersectionality culture and crises into account as relevant contextual factors for making such an approach work second the analysis combines various research techniques geared towards cocreating practical solutions innovative tools and policy responses for the effective mainstreaming of transformative equality in public and private institutions the project thus aims to rewire institutions so as to dismantle the structural root causes of gendered power hierarchies
microgelnanoparticles colorimetric sensor for pesticide detection

the microsens poc proposal aims to realize a novel nakedeye assay to detect paraquat pq a harmful pesticide that has been banned in europe since 2007 but is still employed in many countries endangering health and the environment globally pq is present at very low concentrations and hence there is an urgent need for sensors with high detection capability to this end building on the knowledge gained during the pis recent erc grant we will exploit the thermoresponsivity of microgels combined with plasmonic nanoparticles integrated in a microfluidic device to improve current detection limits our sensing platform will be realised in a portable format to provide a simple readytouse and cheap test with a response visible to the nakedeye as in a simple covid test that will be designed to enhance detection capability production time and costs the resulting platform will therefore be an important tool for environmental and health surveillance that can also be made available to common people such as farmers and people living in rural areas moreover it will be based on a simple scheme that in principle can be easily extended to the detection of other water contaminants making this proposal highly promising for future industrial actions with direct relevance to society
advancing hydrogen h2 technologies and smart production systems to decarbonise the glass and aluminium sectors

the glass industry will have to be completely decarbonized in the next 30 years the lifetime of a glass furnace is about 1215 years so it is urgent to start innovating because the year 2050 is only 2 furnaces away h2glass aims to create the technology stack that glass manufacturers need to a realize 100 h2 combustion in their production facilities b ensure the required product quality and c manage this safely h2glass will address the challenges related to nox emissions and high flame propagation speed process efficiency and supply of h2 for onsite demonstrations digital twin techniques will be critical for riskbased predictive maintenance optimized production control and combustion system control hydrogen will be supplied by a portable electrolyser cofunded by the industrial demonstrators and the oxygen produced will be reused in the process the h2glass technologies and design solutions will be validated up to trl 7 on 5 industrial demonstrators from 3 segments container glass flat glass and glass fibre which together represent 98 of the current glass production in the eu the expertise of partners such as steklarna hrastnik ptml pilkington owens corning and stara glass representing the state of the art sota in the use of h2 in the glass process will be an asset for the h2glass consortium a demonstrator for the aluminum industry hydro will prove the transferability of the basic solutions and underlying models to energyintensive industries that have similarities with the glass manufacturing process thus strengthening the impact of the project in eu the glass and aluminium industries employ 400000 people in europe generate 35b and emit ca215 mt co2e the innovations generated by h2glass will potentially create 10000 new jobs and unlock 1 5b revenues for glass technology deployment 17b investments and 200000 new jobs for green h2 and cut emissions by ca80
illuminating the enteroviral life cycle

enteroviruses are highly prevalent pathogens that have enormous clinical and socioeconomic impact wellknown examples are poliovirus coxsackievirus enterovirusa71 enterovirusd68 and rhinovirus although important insights have been obtained in the enteroviral life cycle many important questions remain unanswered due to shortcomings of current imaging and biochemical methodologies there is a high need for novel technologies that allow sensitive and realtime observation of the dynamics and localisation of viral rna viral proteins and host factors at the singlecell level my longterm goal is to understand enterovirus replication and translate knowledge into the development of antiviral drugs my lab has a longstanding track record and has made many important contributions to understanding the molecular mechanisms of enterovirus replication and the formation of viral replication organelles recently we constructed a reporter virus that in combination with highresolution microscopy allowed for the first time to visualize translation and the regulation thereof of single enteroviral rnas in living cells the goal of this project is to visualize and dissect the spatial and temporal regulation of different phases of the enterovirus life cycle as a first step novel recombinant reporter viruses for application in realtime imaging technologies will be developed these viruses will be used to study viral rna replication virus assembly and prelytic virus release in living cells moreover they will be instrumental to study the structure and composition of the viral replication organelles and the associated replication complexes through advanced cryoelectron microscopy and tomography technologies and proteomicslipidomics analysis respectivelythis project will lead to important new insights into the molecular interplay between enteroviruses and their hosts which is essential for developing urgently needed antiviral drugs
european rare diseases research alliance

the european rare diseases research alliance erdera aims to improve the health and wellbeing of the 30 million people living with a rare disease in europe by making europe a world leader in rare disease rd research and innovation to support concrete health benefits to rare disease patients through better prevention diagnosis and treatment this partnership will deliver a rd ecosystem that builds on the successes of previous programmes by supporting robust patient needled research developing new diagnostic methods and pathways spearheading the digital transformational change connecting the dots between care patient data and research while ensuring strong alignment of strategies in rd research across countries and regions structuring goaloriented publicprivate collaborations targeted at interventions all along the rd value chain will ensure that the journey from knowledge to patient impact is expedited thereby optimising eu innovation potential in rd to support its ambition and missions erdera has been designed as a comprehensive and integrated ecosystem of which structure can be compared to an institute encompassing three main parts i funding ii internal in house clinical research network that implements research activities targeting clinical trial readiness of rds and accelerating diagnosis and translation of research discovery into improved patient care and iii related supporting services data expertise education and training as well as an acceleration hub that serve external and internal rd community all supported by allembracing coordination and strategy and foundational international alignment
eurozip european zincion plant

with the h2020 enerz101009255 grant enerpoly successfully developed a zincion battery cell product using production equipment typical to lithiumion batteries the zincion battery offers a costeffective reliable and sustainable solution for stationary energy storage with noncritical materials sourced in europe feedback from customers energy storage integrators is positive but customers want enerpoly to scale production to reduce design barriers timetovolume and timetomarket the european zincion plant eurozip project establishes a customer qualification plant cqp located in europe to improve operational efficiency reduce costs and increase profitability of zincion manufacturing eurozip also refines and matures enerpolys sustainabilityfocused corporate structure and processes to achieve company scalability this scalability will enable commercialization at gwhscale making enerpolys zincion batteries available for the european energy transition
twinning for excellence of the serbian research center for quantum biophotonics

the project objective is to raise the excellence and reputation of the institute of physics ipb in all scientific management and administrational aspects relevant for international ri activities in this context the emerging scientific field of quantum biophotonics will be systematically developed and all aspects of classical biophotonics are going to be significantly improved the final goal is to establish a quantum biophotonics center at ipb with scientific excellence and a research light house character this development will be a result of a tailored institutional strategy for ipb and knowledge transfer through strategic networking with two highprofile european partners friedrichschiller university jena fsu and the italian national research council cnr quantum biophotonics is an emerging field for ultrasensitive and reliable measurements in a wide bioenvironment since classical metrology cannot successfully meet the increasing demand for higher sensitivity biophotonics is a concrete multidisciplinary scientific field with potentially highimpact applications in medicine pharmacy agriculture environmental protection therefore it is crucial that an institutional strategy should include a tailored scientific strategy addressing this specific scientific fielda scientific exploratory project will include the development of all relevant methods and practices learned from the european partners a longterm partner of ipb the faculty of biology university of belgrade is included to help ipb biologists in choosing preparing and cultivating suitable biosamples in particular the project consortium is pursuing the following project goals regarding the expansion and strengthening of the resources and know at ipbideveloping a shortterm institutional strategy including excellent research at ipb based on strong development of quantum biophotonics ii improving management administration and organization skills in ipb utilizing