Dragon09/odtu_chatbot huggingface dataset:
renewable and safe aromatic compounds as replacements for substances of concern

fossilbased aromatic chemicals like phenol bisphenol a bpa bpa derivatives and alkylphenols are produced on a million ton scale and are commonly used in surfactants flame retardants and plastics however they also raise serious environmental and health concerns especially in applications that result in potential exposure to the body such as detergents furniture textile or food packaging therefore this multidisciplinary eu project aims at developing renewable compounds as benign alternatives for current aromatic chemicals following the safe and sustainablebydesign ssbd framework the project will focus on the molecular design of novel biobased compounds as alternatives for substances of very high concern svhc via an inventive catalytic biorefinery of biomass sides streams new approach methodologies nams will be used for hazard assessment of the new chemicals in terms of human health and environmental toxicity machine learning models will be developed for the design phase and for the insilico impact assessment of the novel chemicals successful products will be safe follow the principles of green chemistry demonstrate a lower carbon footprint than their petrochemical counterparts and will have a calculated life cycle and socioeconomic impact formal ssbd reporting in radar will demonstrate the applicability of the framework and support eu policy the selected radar chemicals will be upscaled to multi kg scale and investigated in industrial applications while they will be benchmarked against functional properties of standard flame retardant surfactant or can coating materials radar data will allow mapping of the substitution barriers in terms of supply production cost and performance to reach its goals the radar consortium involves all relevant industrial actors along the value chain ranging from biomass refinery to chemicals production and brand owners in end markets supported by excellent knowledge institutions
skin microbial metabolites and antimicrobial peptides at the interface of skingut inflammation

skin diseases affect 900 million people worldwide despite major efforts gaining insights in the disease mechanisms underlying atopic dermatitis ad the most common inflammatory skin disease isd an effective treatment is currently lacking ad is accompanied by skin and gut microbiota dysbiosis suggesting an uncharacterized interplay between skin and gut furthermore antimicrobial peptides amps that limit growth of bacteria in the host were found deregulated in isds and inflammatory bowel disease most of the hostmicrobe interactions are mediated by microbial metabolites that can spread and affect distant organs interact will investigate how skin microbial metabolites influence skin and gut inflammation through innovative research at two world leading research universities the medical university of vienna austria and university of california san diego usa under the supervision of profs erwin wagner and richard gallo respectivelyrecent results from the applicant demonstrated gut alterations with neutrophilic infiltration and increased fecal amps in a genetically engineered mouse model gemm of ad generated in e wagners laboratory hence this study will test the hypothesis that skinderived microbial metabolites promote skingut inflammation inducing amp expression and neutrophil recruitment using state of the art technologies such as metabolomics and novel gemms as well as patientderived material this project will determine the therapeutic and biomarker potential of microbial metabolites which will have profound implications for isdthe experimental approach combines the applicants expertise in hostmicrobe interactions with e wagners competence in mouse genetics and inflammatory diseases as well as r gallos knowledge of amps and skin microbiome the msca pf will support the applicants career development by fostering acquisition of mechanistic and complementary skills while studying a global health problem and economic challenge
understanding humanrobot bonding to optimize personal support

robots are rapidly entering the human arena as social entities to support education and healthcare where human resources fall short the ease and naturalness with which humans interact with social robots forebode a high potential but also present new scientific challenges i see a paradox of nt wanting to emulate humans in robots but still create the human feel in connectedness ample research has been done in engineering design and computer sciences yet the question from a human perspective is understudied why would one be willing to befriend such a thing while building affective relationships is crucial to prolonged humanrobot interaction no encompassing theory exists that explains how why and when humans would bond with robots my aim is to fill this knowledge gap and unravel the paradox by bridging the fragmented multidisciplinary knowledge in a novel crossdisciplinary and integrative model of humanrobot bonding explaining how and why people differ in relating to robots and when robots can not provide personal support my model identifies key propositions underlying bonding with robots and elucidates how people process reality and mediabased information explicate the role of emotional states relevant needs and affordances empirically examined through varying communication contexts my advantageous multimethod approach pairs fundamental with insitu research tests my model in labstudies wp1 and the real world in education wp23 healthcare wp4 and therapy wp5 it uniquely compares autonomous social robots in different roles in longitudinal designs with new psychometrically sound measurement devices and bayesian statistics to bring required methodological innovations to the field results complement and integrate current perspectives on robots enrich the understanding of communication and has potential groundbreaking implications for science nd society wp6 envisioning expansive applicability of communication robots
upgrade of the centre of excellence lignosilva

the lignosilva centre of excellence for forestbased industry stands for a systematic and structural change in the research landscape of the forestbased sector fbs the eu has made a strategic turn towards a circular bioeconomy striving for a lowcarbon society based on renewable sources including wood biomass it requires to transfer of knowledge and brings new innovation into fbs practice fbs research landscape in slovakia as well as in countries with similar political histories is highly fragmented and loses much of its potential due to insufficiently organised structures and strategies moreover it is not linked to collaboration with westernnorthern eu countries in the long run this affects the entire value chain the overall objective of the coe is to contribute to overcoming these shortcomings by upgrading the existing lignosilva center of excellence coe the essence of upgrade lies in institutional reform that introduces european science management standards increases excellence expands research capacities digital transformation based on the implementation of forestry 40 and pulp paper 40 into coe researchinnovation activities support for open science and more efficient knowledge transfer to fbsthe main goal is to bring excellent research and applicable innovation into fbs in three research areasintelligent technologies and systems supporting wood production and industrial wood processingpulp and paper technologies for biodegradable packaging and special papers development with multifunctional properties recycling technologies and use of cellulose sludge and wood ashcoe lignosilvas objective will be reached by concentrating the research and infrastructure capacities of the national forestry centre and the pulp and paper research institute in bratislava they will build up and foster cooperation with the advanced partners fraunhofer wilhelmklauditzinstitute germany
maritech talent programme

the maritech talent will develop a twin transition intrapreneurship skills development programme bringing maritime industry professionals and innovative enterprises with concrete digital solutions together in a twoway learning experience the programme will provide necessary twin skills for the maritime workforce support to deep tech solutions providers developing key technologies for unlocking the twin transition in the maritime industry th maritech talent programme will apply a challengebased intrapreneurship model which will nurture learning by working on the most pressing needs identified by the ports and maritime companies themselves teams consisting of current workers and deep tech startups scaleups and smes will work together to apply concrete solutions undergoing the necessary training on the way on the one hand the programme will secure the required skill set for the maritime workforce related to the green and digital transition they will acquire operational knowledge in key digital domains enablers of the twin transition in the maritime industry such as machine learning and data analysis for predictive maintenance energy management systems system integration automation remote operation cybersecurity and enavigation through direct collaboration with deep tech solution providers on the other it will provide valuable insights and feedback on the relevance and effectiveness of the applied digital solutions as a final result maritime companies and ports will gain indepth insights into the benefits digital solutions can bring to their operations while at the same time their employees will become skilled and confident in their use
unravelling apoe4 contribution to taumediated synaptic degeneration in ad by combining advanced proteomics and super resolution microscopy

alzheimers disease ad is one of the biggest scientific and socioeconomic challenges of the 21st century currently there is no cure aggregates of amyloid and tau protein along with neuroinflammationgliosis are hallmarks of ad that lead to synaptic and neuronal loss as the basis for cognitive decline the latter correlates closely with the brain distribution of tau aggregates providing a strong incentive to investigate a link between tau accumulation and synaptic degenerationbrain apolipoprotein e apoe mainly produced by astrocytes is essential for lipid transport to neurons and synaptic functions apoe4 isoform is the strongest genetic risk factor for ad and contributes to taumediated neurodegeneration determining how apoe4 controls taumediated synaptic degeneration is thus essential to understand ad and develop efficient treatments yet this requires fine characterization of apoe4 functions at taudamaged synapses with a synaptic resolutionsynapoe will test in 3 work packages the hypothesis that apoe4 worsens taumediated synaptic degeneration by altering the astrocyteneuron interactions at the synapse1 synaptic changes identify directly at taudamaged synapses the apoe4mediated structural and functional synaptic changes2 protein players identify the protein players underlying these structural and functional synaptic changes3 mechanisms discover the mechanisms through which apoe4 promotes tauassociated synaptic degeneration based on the protein players identified in wp2synapoe aims to decipher how apoe4 drives taumediated synaptic degeneration providing a deeper understanding of ad pathophysiology synapoe achieves unprecedented synaptic resolution by combining advanced proteomics super resolution microscopy at synapses electrophysiology and behavioral testing this will help unravel the mechanisms leading to synaptic loss and subsequent cognitive decline providing new targets for drug design to protect synapses
apobec mutagenesis a novel achilles heel of breast cancer

apobec mutagenesis is a cellular mechanism by which genetic alterations are acquired somatically driven by apobec enzyme family members this mechanism is prominently observed in 15 of primary and 25 of recurrent breast cancer the most common cause of cancerrelated death in middleaged women current evidence suggests apobec mutagenesis contributes to all disease stages ie cancer initiation progression and treatment resistance the core idea of the amber project is that unravelling the mechanism of apobec mutagenesis induction and maintenance will turn this mechanism into breast cancers achilles heel to prove this i will answer several challenging research questions why is apobec mutagenesis operational in breast cancer how does apobec contribute to disease progression can we target apobec mutagenesis or apobec driven tumours specifically first i will reveal epidemiological and molecular evidence for factors inducing apobec mutagenesis in breast cancer this may help to prevent apobec mutagenesis from occurring potentially decreasing breast cancer incidence second using global and single cell genomics i will secure a link between apobec mutagenesis and disease progression giving leads to delay progression third i will exploit a potential vulnerability of apobec driven breast cancer since i have found that these tumors may depend on a proficient homologous dna repair hr pathway when experimentally confirmed targeting hr may extinguish apobec driven disease finally i have observed that apobec mutagenesis associates with a profound immune response i hypothesize that this is due to a new type of neoepitopes being produced if proven true targeting these neoepitopes provide another effective means to eradicate apobec driven tumors i am confident amber will provide the fundamental insights into apobec mutagenesis needed to turn it into an achilles heel which may help to prevent delay or cure apobec driven breast cancer
airbased solar thermal electricity for efficient renewable energy integration compressed air energy storage

highly efficient energy conversion of solar power and storage will play a vital role in a future sustainable energy system thus this project focuses on the development of a novel highefficiency solar thermal power plant concept with an integrated electricity storage solution the project combines airbased central receiver concentrated solar power csp and compressed air energy storage caes to maximize conversion efficiency and power grid energy management enabling a new operation strategy and business models the hybrid concept initiates a futuristic era with adaptive renewable power plants producing both electrical and thermal energy including process heat supply and reverse osmosis desalination because cheap offpeak electricity is used to provide the air compression work of the topping brayton cycle the overall peak solartoelectric energy conversion efficiency of the proposed power plant may reach up to 40 efficiency which roughly doubles the peak efficiency with respect to stateoftheart csp technology the projects activity will cover the technoeconomicenvironmental optimisation of the innovative cspcaes plant using representative boundary conditions provided by grid operators and specialised partners as well as the development and extensive testing of key components needed for its implementation the main development will cover i an advanced highefficiency solar receiver ii optical sensors and aibased control iii optimized caes with heat exchangers and compressorexpander detailed designs and iv innovative integration of desalination the proposed technology is set forth by an interdisciplinary partnership spanning the entire csp value chain targeting a trl of 67 the asterixcaesar concept will be validated with a demonstration scale of 480 kwth prototype in a relevant environment
interaction of elastoinertial turbulence and material microstructure interet

transport and handling of complex fluids is an important contributor to world energy consumption 10 is estimated to come from pumping suspensions and improving their mixing and heat transfer is a key for new applications from process industry to medicine a tiny amount of polymers making the fluid viscoelastic can completely change its flow reducing turbulent friction and pumping power by around 70 at large scales but creating a whole new kind of turbulence at small scales elastic turbulence has recently received exponentially increasing attention as a promising way to increase mixing and heat transfer at small scales eg labonachip applications efficient cleaning and storage of fluids in the ground but also as undesired source of chaotic flow paths and friction cell sorting blood flow however large gaps exist in understanding elastic and elastoinertial turbulence between conflicting experiments and theories and multiscale interactions needed to sustain itthe interet proposal will revolutionize the stateoftheart understanding of elastic fluids turbulence and its interaction with material microstructure by synergetic simulations and experiments that were impossible until now this will be achieved by our highfidelity methods that for the first time enabled threedimensional studies of elastoviscoplastic fluid turbulence suspensions of tens of thousands of particles and experimental timeresolved measurements on microscale theories for newtonian turbulence do not hold for elastic fluids and there is an urgent need for improved theories and models in wallbounded turbulence of complex fluids interet proposal aims to i perform the first simulations and experiments of eit in matching wallbounded geometries ii apply methods for direct experimental measurement of timeresolved stress fields and compare with simulations iii improve microscopic models and predictions of elastic instability and turbulence
combustion of liquid ammonia assisted by plasma discharges as a novel and clean energy conversion method

caipirinh3a aims to overcome the technical barriers hindering the uptake of ammonia as an alternative fuel by developing and demonstrating an entirely novel technological concept the plasma mist ammonia plasminh3 burner a first of its kind plasmaenabled selflearning combustor burning efficiently liquid ammonia with ultralow nox emissions leveraging detailed and accurate kinetic models innovative injectors nonequilibrium plasma systems for plasma assisted combustion and tailored combustion control strategies caipirinh3a will generate a truly vibrant and multiphase cocktail of chemical species which will activate multiple synergetic effects for enhanced combustion in a smart framework the targeted performance metrics are outstanding and go far beyond current paradigms a thermal efficiency comparable to conventional diesel engines 40 b tier 4 nox emissions 75 gkwh c 50 decrease in ignition delay and extension of the flammability limits by 20 d near zero ammonia concentration in exhaust 10 ppm the technological feasibility and future potential of caipirinh3as concept will be investigated through extensive testing at trl4 and holistic impact assessment studies seamlessly integrated in a future clean ammonia economy and in line with strategic eu action plans fit for 55 green deal caipirinh3a holds promise for a sustainable future for our societies with vast environmental and socioeconomic impact in the power generation and all transportation sectors during the project this promise will be fostered through targeted communication and dissemination actions as well as the development of tailored business models for future exploitation hence caipirinh3a paves the way for a disruptive solution which is eminent and urgent towards the reorientation of the energy conversion sector from fossil fuelbased to carbon freebased combustion systems and the ultimate goal of climateneutral europe by 2050
quantum and classical ultrasoft matter

qluster is constituted as a collaborative network for advancing research in fundamentals and applications training esrs with broad skillsets and high adaptability to the increasingly knowledgebased economy of the eu and with a strong commitment to communicating science to society despite similarities in phenomena language and methods employed to study clustering and mesophase organization across widely different length scales from subatomic to macromolecular a coherent effort to bring distinct communities in classical and quantum soft matter together has not been yet undertaken our objective is to advance the fundamentals in such fields far beyond the state of the art crossfertilizing and creating permanent ties between communities that have evolved separately so far and fostering the transfer of knowledge essential for a broad range of applications the ambitious research and training programme will address the properties of classical and quantum soft matter systems under a common framework based on the underlying ultrasoft interactions of the constituents ultrasoftness is the key factor leading to the observed complexity in the dynamics structure and response to external drives of these different entities complex polymers soft colloids rydberg atoms in optical lattices vortex matter in superconductors etc qluster comprises a unique theoryexperiment balanced team of specialists in quantum optics polymer physics and macromolecular chemistry among others providing a valuable platform for communication between the different communities of research in ultrasoft matter the impact in the academic and private sector of the eu will be broad there are no previous examples of similar initiatives in the world and qluster will put the eu in a privileged position through fostering transfer of fundamentals and methods to innovate in largescale sectors as eg tyre manufacturing and to find innovative applications of quantum science
industrial water circularity reuse resource recovery and energy efficiency for greener digitised eu processes

resurgence addresses industrial circular water systems in a wide perspective which embraces efficient technologies for water circularity energy and feedstock recovery with the aim of contribute to eu climate neutrality circularity and competitivenessresurgence will work in 4 case studies that include 3 industrial sectors pulppaper chemical and steel as well as a 4th case to explore the synergies between urban water treatment and industriesinnovative solutions will be tested for water treatment membranes electrochemical technologies adsorbents advanced oxidation processes and hybrid biological systems exploring also the recovery of energy heat electricity biogas h2 and feedstocks bioactive fenols biopolymers cellulose lignin latex acrylic polymers phosphate nitrogen biochar mofs and metals including critical raw materials digital tools will be also developed and applied including models for energy water and risk management physical and software sensors for data acquisition digital twins and decisionsupport tools enabling optimal water treatment technology setup and daytoday operation with seized flexibility opportunities on smart gridsthe project will be guided by a comprehensive sustainability and economic assessment to support by evidence the gains of these technologies togheter with hs analysis local effects multiplication of case studies is pursued by promoting seeds of future hubs for circularity a comprehensive consortium of 20 partners from 11 countries covering the whole geographical scope of the eu and with international cooperation with turkey and pakistan will work together to achieve significant outcomes and produce longterm impact