Dragon09/odtu_chatbot huggingface dataset:
building sustainable and resilient ecosystems with the convergence of naturebased solutions and digital technologies

in response to the pressing challenges posed by rapid urbanization and climate change innovative urban solutions are needed naturebased solutions nbs and digital technologies dt have emerged as promising strategies to address sustainability and resilience issues integrating nbs which harnesses natural systems with dt which offers robust decisionmaking tools offers a compelling pathway for climate adaptation however the convergence of nbs and digitalization remains unexplored this research focuses on horizon europefunded urban planning projects including the life program known for their commitment to sustainable development and climate adaptation analyzing nbs and dt integration in these initiatives using data from the web of science google scholar the life program and other relevant sources buseeco aims to identify strengths weaknesses and areas for improvement to enhance this analysis advanced methodologies will be employed engaging experts through the delphi method will gather diverse perspectives clarify challenges and establish consensus on integration themes multicriteria decision analysis will help select projects for indepth analysis and advanced linear and nonlinear regression models will unveil correlations and patterns in nbsdt convergence forming a foundation for evidencebased decisionmaking by combining these diverse approaches with a focus on nbsdt integration in european urban planning buseeco aims to elevate sustainable urban development prof santiago is wellsuited to guide buseeco from the perspective of science and technology studies sts usals track record in hosting marie curie fellows and proficiency in project management ensure a supportive research environment buseeco will advance my career by providing me with multidisciplinary skills and training especially in the sts field it aligns with the european horizon framework and aspires to establish sustainable urban ecosystems for castile and len
lensless labelfree nanoscopy

optical nanoscopy has changed the seeing is believing paradigm this was achieved within a limited field of view fov100m2 and required fluorescent markers largefov highthroughput live unimpaired cell imaging is crucial for biology and biomedicine hence improving the space bandwidth product sbp using timeconsuming scanning stitching is not a good solution lensless holographic microscopy lhm inherently bypasses fov limitations by using full sensorsize hologram reconstruction for labelfree object information retrieval its major limitation not yet addressed is its low lateral 1m and axial 3m resolution i will overcome this fundamental problem by pioneering deep uv duv lensless holotomographic nanoscopy lhn as a simple and compact device easily operated inside the cell chamber or outside the laboratory in contrast to lensbased systems owing to dna damage duv is used to sterilize and never image biosamples this paradigm will be shifted to provide a breakthrough 10 giga pixel sbp via a lowdose duv opticalelementsfree no cost no radiation loss lensless setup with a worldsfirst fullangle tomographic scenario numerical aperture 1 and a new class of reconstruction algorithms to decrease the effective pixel to 100 nm and remove background noise i will use lhn to enable the discovery of a new mechanistic understanding of extracellular vesicles expression and intake within large live cell cultures with singlevesicle resolution evs nanosized lipid spheres released by virtually every cell type are currently emerging as novel disease biomarkers and drug nanovehicles lhn is a new research field that inherently makes this a highrisk project but the potential gains are also high as a new era of simple ultrahigh sbp nanoimaging might be opened the proposed multidisciplinary project calls for nearunique expertise in computational microscopy and digital holography which i acquired in cooperation with international leaders
dosimetry of ultrahigh doserate electron beams at solidwater interfaces in electron microscopy a key advance in hydrated samples research

electron microscopy em has played a key role in the discovery of many new materials as well as the elucidation of the role of defect structures and interfaces on material properties and behaviour current electron microscopes are capable of maintaining the relevant hydrated state of samples by means of cryofixation techniques or by using dedicated liquid cells this opens up the possibility of investigating crucial interfaces such as those in complex aqueous systems that despite their significance remain poorly understood the study of watersolid interfaces in the em is currently limited by the sensitivity of aqueous samples and interfaces to the action of the electron beam knowledge of the fundamental chemical processes induced by interaction with the electron beam is needed for the interpretation of results prediction and design of experiments and to potentially mitigate electronbeam effects here i propose to develop novel instrumentation and approaches to allow for the direct determination of the yields of radicals and molecules produced as well as reaction kinetics in the em and at the interface between materials and aqueous solutions this new concept will permit us to precisely assess the effect of important factors in the radiolysis of aqueous solutions inside the em such as the very high electron dose rates the supports liquid volume temperature or the effect of nanomaterials interfaces this newly accessible knowledge will lead to the interpretation of numerous em experiments and will be used to develop novel datainformed adaptive scanning approaches specifically designed for in situ dynamic acquisition with minimal chemical effects in the samples an important goal of this project is to conceive new predictive models for the radiolytic chemistry produced during em experiments which will open the door to the future design of mitigation procedures for radiolysis damage in em
integration of advanced experiments imaging and computation for synergistic structureperformance design of powders and materials in additive manufacturing

the proposed project aims to collaboratively integrate modern data system experiments imaging machine learning and predictive engineeringphysical modelling for additive manufacturing am and materials developments through focused knowledge transfer close interdisciplinary teamwork and fusion of the academicindustrial researchresource the team will jointly establish a systematic data system of the structure properties defects and distortions in am of a range of materials at different scales and use the data for materials development and am process optimisation the effect of am processing and surface treatments on the surface integrity and functional properties eg corrosion resistance of am materials is to be systematically established the project will develop practical imaging and processing algorithms for the analysis design and joint quality control for the input materials in am including powder production engineering and key physical modelling is to be integrated with machine learning for predictive composition and structure design for optimum synergy between printability properties and performances materials development balancing printability and structure properties will be focused on advanced materials requiring critical phase control in am including duplex stainless steels amorphous glass metals and mg the advanced data and materials will serve as a pivoting platform for future research and innovation in am speeding up material development within the full product development life cycle through focused intersectoral and international knowledge exchange and joint ri within a multidisciplinary team the project will contribute to the continuous practical applications of industry 40 technologies and development for industry50 in am further enhancing the design freedom in composition and structure for applicationspecific products and accelerating the researcher development with lasting impact in the eu and beyond
merging scientific evidence with regulatory practices and leveraging identification of endocrine disruptors using new approach methodologies

endocrine disrupting chemicals edcs are substances that alter the function of the endocrine system and negatively affect human and animal health in recent decades there has been a significant increase in for example reproductive disorders and gender incongruence along with a decline in fertility rates all of which may be linked to edc exposure the eu has highlighted edcs as substances of high concern and aims to minimise exposure of humans and the environment by improving regulation and policy yet there remain important gaps in our understanding of the impact of exposures at critical life stages and the tools for identification and ultimately regulation of edcs the merlon project addresses these gaps bringing together worldleading experts in endocrinology chemical safety assessment developmental and molecular biology epidemiology toxicogenomics toxicokinetics modelling regulatory toxicology psychology psychiatry and research ethics we will investigate edcmediated effects on sexual development providing human data on the role of edc exposure during fetal development and changes in minipuberty connecting to puberty reproductive function and gender incongruence using existing biobanks and cohorts merlon will apply and develop 3rcompliant new approach methodologies nams focusing on sexual development and function and the effects of edcs thereon our cuttingedge approaches incorporate transcriptomics pharmacokinetic models biomarker identification and the use of adverse outcome pathways which we will utilize to develop a roadmap for edc identification making the best use of nams into the future with merlon we will engage eu risk assessment bodies public health authorities regulators scientists and researchers healthcare providers and citizens this will ensure all relevant stakeholders have the evidence they need to minimize edc exposure and support effective and evidencebased regulations and policies
using microbotanical remains and modelling to trace migrations of bantu and prebantu expansions in central africa

the bantu expansion was a transformative human migration identified with linguistics that spread farming over much of africa there are competing theories to explain how bantu people spread agriculture from their origin in cameroun across one of the largest continental masses on earth into regions inhospitable for farming such as the congolian forests and the zambezian savannahs bantu people are thought to have adopted agriculture in the sahel before undertaking a series of migrations through forest or savannah corridors east of the atlantic coastal forest and possibly along the coast gradually bringing a stockraising and crops to the entirety of central africa plant remains show the use of arboriculture oil palm canarium and savannah crops cowpea and pearl millet while later migrations incorporated sorghum chicken and cattle however forest crops such as banana sugarcane yams and taro that came from southeast asia are the dominant foods in central africa today however it is unknown if these crops powered the bantu expansion africa was a heterogeneous landscape of foragerfarmerpastoralists interactions and some bantu adaptations to the humid environments might be from prebantu agriculturists for example use of southeast asian crops this project will investigate the prehistoric economy in two poorly explored areas of central africa through reconstructing subsistence with plant microremains phytoliths and starch using sediment from archaeological sites along the envisaged migration routes in central african republic and uganda the resulting data will be combined with archaeological data demographic parameters and geography to model these expansions and test hypothesised routes against linguistically inferred routes in savannah corridors and forest these results will provide the first reconstruction of the early food producer economy while modelling will assess the pathways of this transformative event
stereodefined fluorinated tetrasubstituted olefins by catalytic crossmetathesis

practical strategies that provide facile access to tetrasubstituted olefins bearing a fluorine atom andor a polyfluoroalkyl moiety are crucial to drug discovery and development and are therefore in high demand equally important and soughtafter are reliable and stereocontrolled methods for modifying such alkenes nonetheless such methods are scarce and those available are severely limited in scope in this context catalytic olefin metathesis offers a unique disconnection to access modifiable tetrasubstituted alkenes in either stereoisomeric form still there are no more than a handful of such reactions with all ringclosing metathesis rcm processes affording a cyclic alkene bearing two methyl groups there is only a single reported example of a crossmetathesis cm reaction that affords a tetrasubstituted olefin as a stereoisomeric mixtureinspired by recent progress by the host group we will develop new cyclic alkylidene catalysts that are designed to promote formation of stereodefined tetrasubstituted fluoroalkenes by stereoretentive cm the substrates will be readily available trisubstituted olefins and commercially available ff3csubstituted alkenes the products will be valueadded tetrasubstituted olefins bearing a ff3c moiety as well as a modifiable ccl or cbr bond the method will be applied to the synthesis of fluorinated analogues of natural products such as fluoropateamine aanother key aspect will be application to the modification of important drugs our goal will be to utilize the new catalytic chemistry to generate analogues that might exhibit superior bioactivity or be active in a different disease area we will transform entecavir or barmumycin to their polyhalogenated analogues which will be tested for in vitro bioactivity through collaboration with experts the conversion of readily accessible olefins into their polyfluorinated tetrasubstituted analogs holds considerable and asofyet untapped promise for drug discovery
health innovation procurement support services

innovation procurement in health includes several complex processes including but not limited to needs identification and assessment market maturity assessment supply value chain rearrangement digital transformation and reorganisation demand business case definition and suppliers business models alignment new roles for value chain actors as suppliers users consumers cocreation of solutions regulated by contracts complying with the eu treaty principles transparency open competition nondiscrimination and equal treatment proportionality and mutual recognition value generation along the innovation pathway investors support and risks distribution between the demand and the suppliers such issues should be understood and addressed by all participants in the ecosystem to effectively execute innovation while also mitigating inherent risks throughout the innovation pathwaythe project addresses the critical needs of public procurers hospitals health system and insurers and the innovation providers small and mediumsized enterprises smes and industry within the healthcare sector through the creation and activation of a sustainable and scalable platform of specialist advisory services on public procurement of innovationthe solution takes as a starting point the individual expertise and know how built up by each of the consortium partners in their work within the healthcare sector dating back to 2012 which covers distinct perspectives including providing sme support incubation and acceleration providing consulting services on the sides of public procurers and innovation smes providing legal expertise on public procurement exercises providing access to market access to finance and fast tracking innovation support services based on the diverse set of experiences the consortium partners have garnered in their own spaces they are uniquely well positioned to join forces and address the existing challenges in bridging fragmentation gaps
transport layer engineering towards lower threshold for perovskite lasers

towards demonstrating new electrically pumped lasers based on the emerge metal halide perovskite it is necessary to sandwich the perovskite thin film into transport layers for the integration of electrical devices however it is challenging to maintain the low threshold when introducing transport layers the appearance of perovskitetransport layer interfaces which is absent in most optically pumped perovskite lasers is even considered as detrimental factors to lasing actions by carefully integrating the perovskite films into electrical device structures though reaching very high injection current densities 1 kacm2 often fails to realize lasing actions the next urgent milestone towards electrically pumped perovskite lasers would be realization of low threshold when incorporating transport layers this project has the goal to reduce lasing threshold of perovskite devices through transport layer engineering a strategy which is the key step towards realizing perovskite lasers i will take a holistic approach where two novel strategies are proposed independently two objectives will contribute to solve an important challenge on interface engineering towards electrically pumped perovskite lasersobjective 1 to reduce the surface recombination loss for low threshold i will seek effective approaches to passivate perovskite films through transport layer engineering leading to suppressed radiative and nonradiative recombination loss at perovskite boundariesobjective 2 to reduce recombination loss channels caused by hot carriers for low threshold i will achieve this objective by hot carrier management via selective transport layers aiming at suppressing hot carrier injection and facilitating hot carrier cooling
european corechip for space applications

cochisa aims to foster the european nondependence in terms of critical rf components for space applications for this scalable multichannel radiationhard beamforming corechips operating in xband 10 ghz as well as kaband 28 ghz will be developed the scalable approach will allow to increase the number of beamforming channels as well as to scale the system to higher operational frequencies cochisa does not only focus on the ic itself but also a costeffective plastic nonhermetic mmic packaging process supporting space applications by robust encapsulationfurthermore a fully european supply chain for the corechips will be established based on the european foundry and packaging partners this includes the availability of a proven radiationhard sige bicmos technology with qualified radiationhard libraries due to the establishment of the european supply chain the midterm impact will be the wider use of the european radiationhard technology increasing the number of itarfree european spacegrade componentsa main objective of cochisa is to reach at least trl 7 for the developed and packaged corechips xband and kaband this trl level will be proven by the scheduled radiation and reliability tests during the cochisa project a dedicated work package will prepare the commercial exploitation and market introduction of the project results especially to make the developed corechips available to the european and global space industry
collective effect with ordered nanofibertrapped atomic arrays as efficient lightmatter interfaces

efficient interactions between photons and quantum emitters are at the heart of numerous quantum information devices such as quantum memories switches or gates using chains of individual cold atoms trapped close to an optical nanofiber the goal of the proposed research is to exploit the enhanced linear and nonlinear quantum interactions that can result from the unique features of such onedimensional ordered arrays periodically arranged atomic structures indeed exhibit specific light scattering properties ie bragg reflection super sub and even selective radiance the interaction of guided light with ordered arrays can lead to tailored functionalities unavailable in current lightmatter interfaces novel and resourceefficient quantum memory and gate protocols will be targeted this project will push this original lightatom array paradigm towards building blocks for future quantum technologies the candidate with a strong background in atomic physics quantum optics and nonlinear optics will exploit his expertise to develop the project while extending his skillset towards the implementation of quantum information networks and further developing his innovation and leadership abilities during the fellowship
rational development of nanocrystalline drugs for skin administration

alternative drug delivery is one of the most promising solutions for an increasing number of geriatric and cancer patients heavily challenged by the oral route treatment crystals4skin project targets skin as a pathway for localsystemic therapeutics bringing groundbreaking approach at the cutting edge of biotechnologies so far only particlesize nanomaterials have been explored and used for the skin application extreme potential of the crystal form and surface diversity has not been considered as the source of a product innovation for healthier society yet crystals4skin aims to fill the gap in current state of knowledge by the innovative research of nanocrystalsskin interaction through the integration of structuretopropertytofunction principles bridging chemical matter and biology with cocrystals selected as the models allowing the study of different composition bulk and surface characteristics the research will employ the highest knowledge from the fields of crystal structure analysis simulations synthesis physicalchemical characterisation permeation and toxicity studies targeting beating cancer plan one of the eus flagship initiatives together with the united nations good health and wellbeing sustainable development goal crystals4skin brings together experts in crystal engineering pharmaceutical technology and nanomaterials for biomedical applications to answer the burning question is it only the size that makes the nanocrystals an extremely promising material of the future or are there other structural attributes driving their performance within the skin crystals4skin aims to find the answer and meet the current discussions between regulators academics and industrial parties on the control and use of safe and efficient nanomedicines