Dragon09/odtu_chatbot huggingface dataset:
challenging autonomous spacecraft through trajectory optimization with robustness

a new space era is coming numerous miniaturized probes will soon pervade the solar system for commercial and exploration needs constellations made of thousands of spacecraft will soon revolutionize spacebased services in the next future minor bodies will be the final destination of diverse space missions since they can give answers to the origin of life and provide resources for the sustainable development of the humanity however the stateoftheart is to control space probes from ground the need for large teams and specific infrastructures yields extremely expensive operations that do not scale for small probesthe castor project challenging autonomous spacecraft through trajectory optimization with robustness will address the spacecraft operation problem by fostering autonomous guidance and control for future small satellites in the vicinity of minor bodies in order to reach its aim the project envisages the definition of an efficient method for robust guidance and control in close proximity and its deployment on appropriate spacecraftcompatible hardware a concurrent methodology will be exploited to implement the highperformance highefficiency hardwaresoftware set validation in a relevant laboratory environment will be performed exploiting the extrema simulation hub developed within the erc extrema project at politecnico di milano and its associated facility raffaello able to simulate the neighbourhood of an asteroidcastor foresees the involvement of two toplevel space agencies nasa and esa and of one of the most important universities in the space research politecnico di milano that will surely help the project to reach its objectives and maximize its future impactthe outcomes from this project will have a significant impact on the future of space exploration and exploitation increasing dramatically the potential scientific return and opening the space and its market to new operators such as small enterprises and universities
extracellular vesiclesmediated crosstalk during human brain development and disease

cellular crosstalk is an essential process influenced by numerous factors including secreted vesicles that transfer nucleic acids lipids and proteins between cells extracellular vesicles evs have been the center of many studies focusing on neurontoneuron communication while the role of evs in progenitortoneuron and astrocyte communication occurring during brain development has not been systematically investigated extracellular signals regulating the development of the brain are key players altered in many neurodevelopmental disorders ndds strikingly we have found that more than 60 of the genes associated with ndds encode for proteins that are loaded into evswith exodevo inspired by new cellnonautonomous mechanisms that we have identified as the cause of ndds i will investigate the role of evs during brain development i will focus on the physiological function of evs that mediate the signals for celltocell crosstalk and combine transcriptomic proteomic imaging and functional analysis of evs derived from human cerebral organoids this will open new avenues in order to tackle fundamental questions such as how different cells communicate and feedback at different times and distances in the highly dynamic process of brain development ultimately this will be investigated in human models of ndds and will allow me to identify pathologically altered cellular crosstalk mediated by evs this knowledge of the cellular processes governing evs biology will provide the basis to better understand novel mechanisms underlying brain development and neurodevelopmental human pathologies and explore new deliverable compounds for therapy my expertise in human brain development and diseases together with the possibility of combing multiple technologies will be indispensable to achieve these essential goals meanwhile exploring these novel aspects of brain development will bring me beyond my current research focus and broaden my perspectives on ndds
towards an ainative usercentric air interface for 6g networks

centric proposes to leverage artificial intelligence ai techniques through a topdown modular approach to wireless connectivity that puts the users communication needs and environmental constraints at the center of the network stack design it all starts with the users objectives and applicationspecific requirements then ai techniques are used to create and customize tailormade waveforms transceivers signaling protocols and rrm procedures to support these requirements this is the usercentric ai air interface aiai that centric will enable to guarantee that centrics aiai can be implemented in practice we will also explore and develop innovative hardware computing substrates with realistic and aiaicompatible energyefficiency properties this includes novel electronics such as neuromorphic computing and mixed analogdigital platforms centric will make this possible by advancing theory algorithms hardware codesign and training and monitoring environments based on digital twins we will focus on providing the desired quality of experience qoe to a given user or type of users while optimizing spectrum usage minimizing energy consumption and guaranteeing emf compliance the results of centric will be validated and demonstrated in laboratory prototypes and its breakthroughs will enable future 6g usecases such as selfdriving vehicles the internet of nano biothings or multisensory holographic communications
exploring multitrophic interactions of defensive insect symbionts at the community level

many animals acquire new abilities after establishing a symbiotic interaction with a microorganism and the last decades have revealed the prevalence of defensive symbioses between animals and microorganisms one of the beststudied cases are aphids that engage in a symbiotic relationship with a facultative bacteria that protect them against parasitic wasps parasitoids parasitoids are small wasps that reproduce by injecting an egg as well as toxic venom compounds into their hosts ultimately killing the host upon parasitoid development to adulthood defensive symbionts however can challenge this process and reduce parasitism success a process that can alter the efficiency of biological control programs against aphids while aphid defensive symbionts have been well studied in the past two decades there is still no direct evidence of the defensive mechanisms against parasitism particularly the interaction between aphid symbionts and parasitoid venom remains unexplored in addition studies have focused on the direct effects of symbionts on parasitoid populations but complex indirect effects on the entire community of aphid natural enemies have been largely overlooked in this multidisciplinary project i propose to fill these gaps in knowledge by 1 unravelling the interaction between parasitoid venom and aphid symbiont protection 2 investigating the indirect effects of aphid symbionts on the insect community of natural enemies and 3 regrouping these themes in a metaanalysis of the scientific literature to empirically assess the effects of insect microbial warfare this proposal will advance our fundamental understanding of the effects of aphid symbionts and it will be of applied interest to improve aphid biocontrol
advanced molecular enantiodiscrimination

enantiodiscrimination is one of the major challenges in contemporary chemistry chiral molecules exist in two nonsuperimposable mirror image forms which induce different effects in biological systems thus they need to be produced in a stereoselective way especially for pharmaceutical use the motivation and societal relevance of this project is based on the fact that if the wrong enantiomers are present in pharmaceuticals their effects can be toxic or even lethal as has been exemplified by the scandal around the use of racemic mixtures of thalidomide in the 1960ies subsequently it became obvious and strongly recommended by the fda and european legislation that medication should contain pure enantiomers therefore there is a strong and constantly increasing need to develop advanced technologies that allow a selective production of enantiomers by new synthesis strategies this challenge is at the heart of the amen project we plan to follow an unconventional concept developed during the erc advanced grant electra in order to obtain single enantiomers instead of racemic mixtures this is achieved by directing the transformation of molecules towards one of the two possible enantiomers with the help of autonomously moving chiral microreactorsthe fundamental strategy has been already validated with proofofprinciple experiments during the erc advanced project and showed extremely high selectivity efficiency and controllability however only at the laboratory scale therefore we plan as a next logic step with technology transfer character to investigate in detail the possibility of scaling up this process and to evaluate its commercial viability and competitivity
environmental resolution mechanisms beyond the nation state a comparative analysis of the implementation of court judgements and managerial agreements

this project studies the national implementation of legal judgements from courts and managerial agreements from noncompliance mechanisms on european and international environmental issues against the background of the increasing impact of climate change and a lack of specialised jurisdiction over environmental disputes beyond the nation state the implementation of legal obligations is a crucial tool to protect earths environment from harm yet systematic insights on the national implementation of socalled resolution mechanisms ie managerial agreements from noncompliance mechanisms and court judgements on supra and international environmental issues are lacking this project will investigate the conditions explaining effective implementation of such agreements and judgements by adapting insights on policy implementation research and comparing processes of implementation across different types of resolution mechanisms it will develop an innovative theorydriven conceptstructural framework based on key conditions from the implementation literature actor preferences institutional legitimacy resolution mechanisms that mirror the existing management and enforcement approaches the framework will enable systematic comparisons across resolution mechanisms and thus account for a diversity of separate but equally valid explanations empirical analysis will follow a mixed methods approach that includes 1 data gathering based on public documents and expert interviews 2 a comparative assessment via qualitative comparative analysis qca including case studies and 3 indepth process tracing of unexpected cases identified in the qca this approach will provide generalisable insights on how different preferences combine with varying degrees of legitimacy and resolution mechanisms to explain the national implementation of managerial agreements and court judgements on environmental issues
smart windows for zero energy buildings

smart windows for zero energy buildings sweb will rely on a variety of innovative smart windows sw solutions and products to meet the market growth potential and address the global environmental challenges faced by the eu to achieve and sustain zero energy buildings market we propose the development of nontoxic abundant longterm functional sw materials photochromic thermochromic electrochromic transparent conducting implemented in parallel with costeffective robust and industrially scalable technologies for fabrication of lowcost thinfilm sw and chromogenic devices with flexibility in design such as photochromic thermochromic electrochromic and selfpowered sw the basis for zero energy buildings in smart cities sweb aims to recruit members of the erachair team that will bring complementary knowledge to the existing core team thereby enhancing scientific excellence increasing visibility and bridging the gap between research to technology transfer this will positively contribute to the achievement of sustainable development goals european targets for clean energy for all europeans the smart specialisation strategy of latvia and contribute to the european research area the shortterm aim is to create a functional era chair team that can implement the strategies defined in the scope of the era chair and ensure sustainability after the end of the project the longterm goal of the sweb is to strengthen the thin films laboratory and the institute of solid state physics in achieving high scientific and innovation results and enhance stakeholders networks with the support of the era chair issp is planning to establish the briefing demo centre for renewable energy in latvia as well as the eu joint graduate school on sw and zero energy buildings completion of these tasks will contribute to the eu becoming a climate neutrality flagship the main task of the era chair is to converge rdi stakeholders policymakers and society
electric vehicles management for carbon neutrality in europe

the electric vehicles management for carbon neutrality in europe ev4euthe electric vehicles management for carbon neutrality in europe ev4eu project will propose and implement bottomup and usercentric vehicletoeverything v2x management strategies creating the conditions for the mass deployment of electric vehicles the strategies will consider the impact on batteries the needs of the users power systems the integration with energy markets and cities transformation the proposed v2x management strategies will be tested in four demonstration sites allowing an evaluation of the proposed methodologies and tools the definition of the appropriate implementation conditions and a consolidation of the most promising solutions and business models technology providers will test different v2x management approaches evaluating their feasibility and adequacy for the existing conditions in cities system operators will estimate the impact of v2x on transmission and distribution levels proposing new services to profit from v2x flexibility mitigating the effect of v2x and supporting the development of both v2x and renewables tools and apps for electric vehicle users will be developed to provide valuable information about the use of electric vehicles and available energy services an open platform that considers interoperability scalability security and privacy requirements will ensure the information exchange between stakeholders and systems the impact of v2x management strategies in different cities will be evaluated in a cosimulation tool considering different perspectives namely the power network cities constraints existing parking lots buildings characteristics etc electric vehicle use patterns and finally v2x management strategies new services green charging sharing charging and surge pricing demand response programs and flexible capacity contracts will be designed and a regulatory framework promoting user adoption will be proposed
targeting tumourhost interactions in paediatric malignant gliomas to reinvigorate immunity and improve radio and immunotherapy efficacy

paediatric highgrade gliomas phggs are malignant deadly tumours developing in infants and children mutations in histone coding genes disturb epigenetic regulation and in cooperation with other oncogenes promote tumour initiation and progression phggs are fastgrowing and diffusive which makes them hard to remove or treat surgery unattainable in midline brain regions and radiotherapy rt remain the only option with transient benefits as median survival is 915 months those tumours are immunosuppressed thus immunotherapy is ineffective we propose that knowledge of tumourhost interactions in the tumour microenvironment tme would reveal novel targets allowing to find new ways to eradicate mutated tumour cells improve efficacy of rt and reinvigorate antitumour immunity to achieve these ambitious goals we built up the international multidisciplinary consortium hitglio we will i use latest singlecell technologies and multimodal imaging to characterise tumourimmune cell interactions in a large spectrum of phgg patient samples ii create cellular and animal models of increasing complexity human gliomamicroglia cocultures dipgderived organoids complemented with ipscderived immune cells and syngeneic phgg mouse models which would be platforms for mechanistic studies and drug screening iii evaluate hypoxiainducible epigenetic inhibitors and blockers of tumourhost interactions to improve rt and immunotherapy responses iv generate nanocarriers functionalised to target immune cells and deliver drugs to the brain v develop more effective cart cells that together with tme reprogramming and rt would boost antitumour immunity vi assess neurodevelopmental alterations and psychological consequences of disease and foster psychological approaches to increase qualityoflife of patients and caregivers the expected outcomes of hitglio would ultimately pave ways to new clinical trials to improve the way phggs are treatedthis action is part of the cancer mission cluster of projects on understanding tumourhost interactions
photoelectrosynthetic processes in continuousflow under concentrated sunlight combining efficiency with selectivity

to be the first co2neutral continent by 2050 europe needs to develop and implement disruptive new technologies based on scientific breakthroughs in this regard utilization of co2 and organic waste as feedstock to generate valuable products will play a key role in turning the chemical industry on a more sustainable circular path in the sunflower project we are going to demonstrate that two highvalue processes co2 or co reduction and glycerol oxidation will be studied first can be synergistically coupled to produce chemicals such as ethylene and lactic acid and fuels using novel photoelectrode assemblies both photocathodes and photoanodes original photoelectrochemical pec device architectures and automated processes the sunflower project is based on the following three hypotheses1 proper engineering of continuousflow pec cells operating under concentrated sunlight will allow current densities similar to the electrochemical ec methods2 one semiconductor alone can supply the necessary energy input for biasfree operation of pec cells while generating two highvalue products3 pec methods can provide superior selectivity compared to their ec counterparts even at high current density operation as the current density and potential can be decoupledto validate our hypotheses we are going to use for the first time the pairing of two highvalue generating redox processes none of them being h2 or o2 evolution concentrated sunlight which has only been used for watersplitting so far customdesigned and developed pec cells elaborating on the photogas diffusion electrode concept machine learning based on the broad dataset collected by the sensors built in the pec system optimizing the performance at a system levelthe proposed combination of these novel approaches will be of groundbreaking nature therefore it opens a whole new arena of solar energy conversion
opensource resilient hardware and software for internet of things

it is common wisdom that security is only as strong as the weakest link in a chain however identifying the chain and its weak links is a huge challenge even more so for opensource hardware aimed at the internet of things iot industrial iot and critical infrastructure most of these devices operate in constrained environments with limited energy budgets and routinely lack essential security and privacy guarantees the primary goal of the orshin project is to create a generic and holistic methodology which we call the trusted life cycle to develop and manage connected devices based on opensource hardware we identified a chain of six essential phases design implementation evaluation installation maintenance and retirement the life cycle will specify how to translate abstract security goals eg build a secure iot product into security policies for the phases and further into concrete security requirements for the building blocks of the product eg use 128bit keysusing this holistic view orshin will address critical links corresponding to three important expected outcomes mentioned in the call to reduce the security threats associated with opensource connected devices1we will propose new models of security properties in order to extend formal verification to the secure opensource hardware realm2to enable effective security audits of opensource hardware and embedded software we will develop practical fast and hardwareaugmented testing techniques3we will create secure and privacypreserving protocols for intradevice and interdevice communication to provide secure communication and authentication methods for connected devicesthese ambitious objectives leading to opensource demonstrators at trl4 are proposed by an international consortium with complementary experience consisting of four hightech smes in collaboration with two excellent academic partners and one important european semiconductor company
exploitation of extreme cavitation conditions for wastewater treatment

one of the most pressing global problems is the increasing pollution of surface and groundwater which threatens the worlds clean water supply and public health wastewater treatment plants wwtps the last barrier between everincreasing human activities and the environment produce huge amounts up to 13 million tonnes per year in the eu alone1 of unwanted semisolid byproduct waste activated sludge was therefore upgrading wastewater ww processes with new circular economy approaches is crucial to achieve the goals of the eu green deal considering was as a resource rather than an unwanted endproduct is the first step towards sustainable ww treatment caviphy will address this need directly by developing a unique device that exploits cavitation to pretreat industrial or domestic was prior to anaerobic digestion ad however this process simple in its fundamentals will never be sufficient to make a substantial contribution to current and future energy needs unless it is extensively modernized and refined to reach its full potential based on the knowledge gained within the erccog cabum we have developed a rotating generator for hydrodynamic cavitation rghc a scalable and costeffective device that works simultaneously as a cavitation generator and a pump with caviphy we will improve the disintegration settleability and dewatering of was resulting in synergistic effects in terms of lower costs associated with reduced volumes of was and environmental burden from its disposal while producing methane a renewable bioenergy source this will have a direct impact on the economics of wwtps as the was associated costs already account for nearly half of the total wwtp operation expenses and will continue to increase