Dragon09/odtu_chatbot huggingface dataset:
allogeneic macrophages for cancer therapy

macrophage cell therapy can become an attractive example of a cell therapy with numerous potential applications among them cancer therapy while tcell based therapies so successful for the treatment of hematological malignancies have yet failed to demonstrate effectiveness in the treatment of solid tumors macrophages are a key component of the tumor microenvironment tme and in principle they are capable of killing solid tumor cells however wildtype macrophages commonly respond to the tme by acquisition of a m2like polarization state in which state they rather support tumor growth and metastatic spread this is a first problem for macrophage cell therapy against cancer besides unlike tcells human macrophages cannot be expanded in cell culture resulting in insufficient numbers of obtainable macrophages and thus limiting their utility for cell therapywe have generated genetically engineered human macrophages which have proliferative potential are resistent to tumorinduced repolarization and thus demonstrate oncolytic activity we want to translate these exciting findings into a celltherapy against cancer oncomac relates to the preparation for and design of a preclinical proofofconcept study for these genetically engineered human macrophages so that we will have a sound basis for the translation of our genetically engineered macrophages into clinical trials in particular oncomac will establish the numerous complex analytical procedures which are required by the european medicine agencys regulatory framework for firstinhuman studies of an atmp advanced therapy medicinal product
6gbricks building reusable testbed infrastructures for validating cloudtodevice breakthrough technologies

6g networks currently only existing as concepts are envisioned as portals to a fully digitized society where the physical and virtual world are blended via boundless extended reality xr and also as an enabler for the digital and green transformation of the european industries to support this vision the network capacity must be increased at least by an order of magnitude while infrastructures must be transformed into a very dense continuum thus academia and industry have shifted their attention to the investigation of a new generation of smart networks and infrastructures it is clear that to win this race towards shaping the nextgeneration communication ecosystem a new generation of testbed infrastructures and breakthrough research and technology development is needed needed as well as a new generation of testbeds to support future research initiative to this end 6gbricks aims to deliver a new 6g facility building on the baseline of mature ict52 platforms that bring breakthrough cellfree and ris technologies that have shown promise for beyond 5g networks moreover novel unified control paradigms based on explainable ai and machine reasoning are explored all enablers will be delivered in the form of reusable components with open apis termed bricks finally initial integrations with oran are performed aiming for the futureproofing and interoperability of 6gbricks outcomes
eosc focus

eosc focus will support the coprogrammed eosc partnership in delivering its mission of establishing open science as the new normal and achieving the key objectives which are outlined in the memorandum of understanding between the european union and the eosc association eoscaeosc focus is a collaboration of eight members of eosca and the eosc association aisbl itself the hub of key stakeholders in the european research environment which provides insights on overarching themes important for the realisation of eosc the consortium demonstrates excellent complementarity across the diverse regions and stakeholder groups needed to ensure appropriate coverage of countries and stakeholders eosc focus will provide an effective eosc stakeholder forum consolidate and enhance existing monitoring frameworks identify strategic gaps to inform future iterations of the sria develop and test resourcing models for a sustainable eosc implement the eosc rules of participation and collaborate with other eoscrelated projects other partnerships and international initiatives eosc focus is organised into six work packages wp 1 project coordination wp 2 stakeholder engagement and management wp 3 sria update and technical development wp 4 monitoring and impact assessment wp 5 sustainability of eosc and wp 6 communication dissemination stakeholder forum the combination of these work packages will help the sometimes divergent activities of the broader stakeholder community to focus on the big goal of delivering eoscthe impact of eosc focus will contribute to the increased availability accessibility and reuse of data it will make research results more accessible for citizens it will increase the quality and outreach of science and thus lead to more results from science and its innovation uptake
scalingup of a highly modular rotating packed bed plant with an efficient solvent for capture cost reduction

in a worlds first hirecord will demonstrate at trl 6 a modular co2 capture plant that will comprise a rotating packed bed rpb absorber and an advanced rpb desorber with integrated spinning reboiler rpbisr the plant will be of 10 td co2 capture capacity and will operate with the advanced apbscdrmax solvent it will be operated on the premises of a naturalgas power plant elpedison of an industrial gas boiler total energies one tech and of a quicklime plant cao hellas highlighting the high modularity and flexibility of rpb processes with flue gases of different specifications the advanced capture plant will allow up to 50 capture cost reduction compared to conventional meabased packedbed technologies this reduction will result from at least 10 times lower space footprint due to the use of the rpbs with direct beneficial impacts on capital expenditures as well as a regeneration energy of 2021 gjtco2 due to the use of the apbscdrmax solvent and the rpbisr these features will also enable 20 and 50 lower environmental and safety impacts as the solvent and operating conditions will minimize emissions corrosion and makeup requirements technoeconomic studies will also include an industrial cluster in northern greece where options of co2 utilization as well transportation and sequestration in nearby geological sites will also be investigated extensive societal public acceptance and policy studies will also be performed including surveys to the over 750 members of the industrial association partner seve
establishing the center for environmental and technology ethics prague

the ethical challenges posed by emerging technologies and climate change have been critically examined by ethicists in newly founded research centres all around the developed world yet there is no comparable research program in the czech republic and only a few relevant research initiatives in the entire cee region the era chair position held by prof mark coeckelbergh one of the most prolific and innovative authors in philosophy of technology and environment will help to remedy this situation by establishing an internationally excellent research center for environmental and technology ethics at the institute of philosophy ip the largest humanities institute of the czech academy of sciences the center will contribute to advancing stateoftheart knowledge in environmental and technology ethics in particular by focusing on issues that are globally underresearched andor imperative in the cee region at the same time the project will enable the ip to implement a set of organisational measures and structural changes in particular in the areas of hr international grant support research management and institutional culture with massive support from the ip management planned and realised in cooperation with the era chair holder these changes will improve the international visibility of the ip helping it to both succeed in competing for eu research funds and better integrate the ip into the european research landscape by deploying smart means of approaching diverse target groups this project aims to overcome the existing barriers between the general public concerned stakeholders and the ips research community as well as facilitate the flow of expert ethical opinions in the wider societal debate in its longterm impact this project shall contribute to further increase in public visibility of ssh research and its relevance for tackling urgent societal and political issues
phasesensitive alteration of light coloration in quadripartite garnet cavity

the elder wand of telecom wizards would coherently change the color of light but while the laws of physics do allow mutating the photon chroma all attempts to date have been very inefficient for large frequency mismatches palantiri will initiate a technological breakthrough by providing a viable development path for integrating the coherent and efficient interconversion of information between microwaves and light on a chip we propose a radically new approach building on quadripartite microwave photonmagnonphononoptical photon hybridization process the idea is to exploit optomechanical effects while inserting a magnetic element that maintains high cooperativity both with a mechanical mode through magnetoacoustic coupling and with the microwave antenna through inductive coupling while exploiting magnetic texture to achieve perfect matching of the microwave precession profile with the optical mode this opportunity has recently emerged from progress in material science which allows the fabrication of freestanding micronsize slabs of ultrahigh quality magnetic insulator yttrium iron garnet the suspension greatly suppresses any leakage of phononic or photonic oscillating energy through the substrate palantiris scientific objectives are to deliver within 42 months a proof of principle onchip analog coherent frequency converter with efficiency of the order of unity trl2 the delivered phasesensitive device will provide the breakthroughs needed to achieve a radical expansion of the connectivity capacity of a backhaul network for enabling highspeed internet access for everyone from any location it will also provide the elementary brick to build the quantumready internet infrastructure of the future to achieve these goals our consortium consists of six academic partners cea mlu cnrs tud icn2 mpg from four eu countries fr de nl es and one industrial partner tsst the global budget of the proposal is 33m
literary attention in short fiction or what literature knows about attention and attention politics

literature knows a lot about attention how it is gained and retained how it is mastered and manipulated as such it can contribute significantly to current research in interdisciplinary attention studies transform debates about attentional crises and offer deep insight into attention regimes we live by litattention explores this fundamentally underresearched knowledge domain of literature about attention and attention politics by analysing literary attention in short fiction as litattention will show short fiction does not only cater to shorter attention spans its development was driven by attention anxieties and struggles for attention control which responded to technological innovation new streams of information the rise of attention studies changing modes of reading growing concerns about the limits of human attentional capacities and intensifying struggles for attention sovereignty integrating approaches from educational psychology computational linguistics and literary and cultural studies litattention has four key objectives it will 1 examine the various ways in which short fiction has been shaped by but also shaped discourses on attention and attention management 2analyse the poetics and politics of attention in short fiction by identifying syntactic semantic and narrative strategies that elicit attention and assess how these narratives reflect upon support or subvert attention regimes of their time 3 develop transferable methodological and conceptual frameworks for examining literary attention 4 introduce the important role of literary attention for education the project is the first to conceptualize literary attention and propose a networked approach for its analysis its results will reveal the crucial role of short fiction in changing ecosystems of attention have a deep impact on education and change the way in which scholars teachers and the general public approach the knowledge and value of short fiction
xchromosome driven speciation through testesexpressed genes comparative population genomics meets scrna analysis in primates

primate x chromosomes evolve extraordinary fast and are also tightly associated with the establishment of reproductive barriers between emerging speciesthe hypothesis of this proposal is that genetic conflicts between the x chromosome and the rest of the genome during spermatogenesis cause rapid x chromosome evolution and build reproductive barriers genetic conflicts for transmission to haploid gametes called meiotic drive will cause nonadaptive evolution which is expected to be countered by other genomic elements that will then be under selection such an arms race is expected to lead to a very rapid evolution of the x chromosome and a fast accumulation of incompatibilities between isolated populations leading to speciation the goal of the project is to identify the underlying mechanisms and the genes responsible for meiotic drive using primates as the study system a priori candidate processes include xlinked genes under repeated fast evolution with a focus on genes targeted by pachytene pirnas and on ampliconic genes population genomics analysis will generate specific hypotheses that will then be tested by following expression of candidate genes during spermatogenesis through scrnaseq and validate findings by ultrasensitive in situ staining of single transcripts and immunohistochemistry finally the behaviour of key genes and processes will then be investigated in incipient speciation eventsspecifically 850 individuals of 250 species of primates with full genome data will be analysed for candidate genes on the x chromosome these genes will be investigated in large scale comparative scrna sequencing analyses of 10000 individual testicular cells from 14 primate species including all great ape species thus allowing expression trajectories through spermatogenesis to be inferred and followed up in functional experimentsthe success criterion is to report on primate speciation genes together with their biological mode of action
beyond selfsimilarity in turbulence

a century of exhaustive turbulence research has allowed the development of a wide range of turbulence closure models analytical parametrisations and scaling laws which enter virtually all design and modelling protocols that involve high reynolds number flows closer inspection however reveals that only two extreme and polaropposite turbulence regimes have been wellunderstood and modelled when turbulence is highlystrained and evolves rapidly or when it is lowlystrained and evolves slowly the inbetween regime of intermediate strain perhaps the most relevant for engineering and environmental applications remains obscurethis proposal is about developing and validating a theory for the intermediatestrain turbulence regime based on the conjecture that it is governed by a universal flowbehaviour termed rapid selfsimilarity which combines elements from both the high and lowstrain regimes the proposed investigation is based on three developments first the accumulation of evidence in the literature that intermediatestrain turbulence dynamics may accept an analytical description known as the new dissipation law second the development of machine learning techniques which allow the extraction of physical insights directly from data third the attainment of mature experimental and numerical simulation methods in fluid mechanics capable of resolving the spatiotemporal properties of turbulent flows the impact of onset is potentially very high as it will improve the understanding and modelling of a wide range of applications of engineering and environmental science connected to intermediatestrain turbulence onset will demonstrate that by focusing on two example applications improvement of wind energy harvesting via enhanced wind farm flow modelling and increase of unmanned aerial vehicle flight efficiency and duration by making use of uav group aerodynamics
integrating network digital twinning into future aibased 6g systems

the overarching objective of 6gtwin is to provide the foundation for the design implementation and validation of an ainative reference architecture for 6g systems that incorporates network digital twins ndt as a core mechanism for the endtoend realtime optimisation management and control of highly dynamic and complex network scenarios to achieve this objective 6gtwin will deliver methods modelling and simulation solutions for the definition creation and management of multilayered virtual representations of future 6g systems where heterogeneous domains ie edge fog and cloud and communication technologies eg cellular optical and nonterrestrial networks ntn coexist the project solutions will be demonstrated in two complementary use cases addressing mobility and energyefficiency challenges aligned with the expected use cases of 6g and the key performance indicators kpi defined in previously funded projects including sns ju streamcd2022 finally the participation of small and mediumsized enterprises smes will ensure that the 6gtwin consortium pays particular attention to the replication reengineering and exploitation of the project outcomes regularly aligning the requirements of standardisation bodies with predicted market needs
a european health data toolbox for enhancing cardiology data interoperability reusability and privacy

cardiovascular disease cvd remains the main cause of mortality worldwide accounting for about a third of annual deaths reuse of both structured and unstructured data has the potential for major health benefits for the population suffering from cvd healthcare data reuse in europe faces privacy and fragmentation issues a high diversity in data formats and languages and a lack of technical and clinical interoperability datatools4heart dt4h will tackle such challenges and develop a comprehensive federated privacypreserving cardiology data toolbox this will include in an integrated platform standardised data ingestion and harmonisation tools providing a common data model multilingual natural language processing federated machine learning differentially private data synthesis generation and 7 language models adapted to the cardiology domain dt4h virtual assistants will help scientists and clinicians navigate through largescale multisource cardiology data these tools will be i implemented ensuring privacybydesign and thorough compliance with european regulations and data standards ii optimised as based on multistakeholder usercentred requirements and iii validated in 7 clinical sites across europedt4h will unlock currently inaccessible health data in unstructured data and allow multisite federated data use together with its toolbox dt4h will leave the legacy of a federated learning platform with an embedded metadata catalogue and ai virtual assistants and the cardiosynth open database of synthetic data remaining as available for further research and ai experimentation effective use of the federated learning platform will improve enable improved ai diagnostic and treatment tools deployment of regulated solutions will extend existing healthcare management paradigms to reduce disease burden finally dt4h tools systems and methodology are highly generalised and will translate well to other clinical and research areas in medicine
harmonised l ife c ycle a ssessment methods for sustainable and circular bio based systems

eus climate target plan goals are compelling all the economic sectors to drastically reduce ghg emissions as a result a global shift from fossilbased feedstocks and processes to biobased systems is being gradually carried out due to the depletion and significant environmental impacts of fossil resources to facilitate the green transition of the european industry a more applicable and realistic environmental assessment of biobased systems is being demanded as a way to demonstrate the improved performance of biobased products versus its unsustainable counterparts and identify the best available technologies to promote the sustainability of industrial procedures and fulfil the zeropollution objectives encouraged by the european commissionin this context the lca4bio project aims at developing and validating a new set of improved harmonized precise reliable and applicable assessment methodologies to properly evaluate environmental impacts and circularity in biobased systems that can be applied in certification schemes thus enabling the international trade of this type of products additionally lca4bio will address the development of new prospective life cycle assessment methodologies considering upscaling and future scenarios via integrated assessment models with manageable levels of uncertainty for an accurate comparison between potential environmental impacts of emerging biobased technologies and current systems in the market to do that different stakeholders in the bioeconomy value chain will be involved in a cocreation process that will permit to consider their requirements and test the adequateness of the methodologies developed by the lca4bio partnersthe new approaches developed in lca4bio are expected to stimulate the growth of the european biobased sectors that could lead to reduce the ghg emissions and other environmental impacts and promote circularity processes along the economy and society
agonists of the microprotein brawnin in the treatment of charcot marie tooth disease

this project will provide proof of concept for the neuroprotective potential of agonists of the mitochondrial protein brawnin we have identified that brawnin is an important regulator of mitochondrial function in neurons mitochondria are essential organelles to support metabolic homeostasis in the cell mounting evidence in the literature demonstrate that mitochondria and more broadly metabolic regulation is central to the function of the nervous system axons are especially affected by metabolic deregulation which can lead to axonal degeneration in this application we propose that increasing the cellular levels of protein brawnin using a genetherapy strategy defined as brawnin agonists will be protective in neurodegenerative disease and we will demonstrate this in models of charcot marie tooth disease a peripheral neuropathy strongly associated with altered metabolism and mitochondria overall our project will provide the first demonstration that brawnin is a target of therapeutic interest in axonal metabolic diseases which we will further develop with the ultimate goal to develop brawnin agonists for patients