Dragon09/odtu_chatbot huggingface dataset:
early inflammatory signatures of ipmn progression

pancreatic ductal adenocarcinoma pdac is a lethal cancer with rising global incidence and poor survival rates early pdac diagnosis is hampered by nonspecific symptoms and by the absence of reliable early biomarkers on the other hand intraductal papillary mucinous neoplasms ipmns precursor lesions of pdac are commonly found during abdominal imaging ipmn management lacks consensus leading to inefficient decisions decisions on empirical assessments of highrisk stigmata hrs and worrisome features wf there is an urgent need for precise ipmn patient classification to guide personalized treatment decisions reducing unnecessary surgeries and late interventionsour ercstg project identified a gene signature marking preneoplastic cells in pdac precursor lesions we propose testing this signature as a biomarker for pdac in ipmn patients to distinguish those at highrisk or lowrisk of progressing to invasive carcinoma successful validation of the signature as a biomarker holds benefit clinical management of ipmn patients mitigating the economic and societal consequences of overtreatment and undertreatment at the same time these activities should advance early detection in pancreatic cancer our multidisciplinary approach and groundbreaking discoveries put us in the best position to tackle this key challenge in immunooncology
superheart a faulttolerant and highly efficient energy hub with embedded shortterm energy storage for high availability electric power delivery

power electronics pe is spreading through society including in mission critical applications however pe devices are prone to failure and high availability is usually ensured using redundancy which is expensive and bulky in the meantime pe allows hybrid ac dc electric distribution which is key to integration of solar power and use of hydrogen as energy carrier but loads can be affected by the limited dynamics of power sources like fuel cells and by disturbances carried by the networkwith superheart we want to build an energy hub connecting power sources and load and able to deliver uninterrupted power to this end we will develop a multiport modular converter with fault ridethrough capability this will be ensured using faulttolerance strategies already proved in the erc poc project uheart improved by the integration of supercapacitors sc to allow using reliable and lowcost mechanical switches to isolate the faulty parts instead of semiconductor switches leading to a significantly higher trl superheart will use sc also for compensating disturbances and the low dynamics of hydrogenbased storage but commercial sc have power and energy densities too low to be practically considered here therefore previously developed highperformance and environment friendly sc will be further optimised in this project and embedded in the converter by optimal codesignin parallel to the technological development we will prepare the monetisation of the ip comprising a market analysis the development of solid business model and techtomarket transition plan and the search for clients and partnersultimately a power converter with embedded sc with availability power density cost and losses 20 better than stateoftheart will have been developed with reduced environmental impact it will be ready for qualification and have undergone field tests potential clients and partners for the development and distribution will have been found
recycling technologies for circular reuse and remanufacturing of fiberreinforced composite materials

the general objective of the recreate project is to develop a set of innovative technologies aimed at exploiting the potential of endoflife eol complex composite waste as feedstock for profitable reuse of parts and materials in the manufacturing industry in the light of this more specific objectives areto develop and validate in relevant environment trl6 novel reuse strategies for large eol composite parts based on smart recognition and inspection for sorting laser induced breakdown spectroscopy high precision dismantling lasershock and repair temperatureassisted reshaping design for disassembly based on reversible joints aiassisted decision support systemsto develop and validate in relevant environment trl6 innovative recycling technologies catalystassisted green solvolysis and electrofragmentation allowing simultaneous recovery of high quality integer clean fibers and of an organic resin fraction reusable as coating material at the very end of the multiple reuse processes of partsto demonstrate at trl6 the use of smart and green reversible thermoset resins as enabling materials for the realization of the next generation of fiberreinforced composites with easier repairability and enhanced reusability facilitating the transition towards recyclablebydesign compositesto develop digital tools for the quantitative evaluation of the environmental and economic performance of the proposed technologies lcalcc as well as their circularity assessment and accelerationto codesign innovative digital learning resources based on moocs gamification and digital twins of some specialty technologies developed in the project with easy adoption and high replicabilitythe objectives and ambition of recreate are fully compliant with the general requirements of the horizon europe digital industry and space 2021 work programme and with the specific requirements of the call horizoncl42021resilience0101
chemical engineering of natural killer cells for cancer immunotherapy

our immune system evolved to protect our bodies from different invaders and to fight against infections and diseases immune cells use sophisticated ways to detect and destroy abnormal cells while sparing our own cells unluckily cancer cells often develop sneaky tricks enabling them to evade this protecting machinery and to survive and proliferate immunotherapy an emerging concept of treatment aims to employ the power of immune system to fight cancer by boosting or reeducation of immune cells one of the approaches the adoptive cell transfer therapy especially in the form of chimeric antigen receptor car cells has shown an unprecedented success in the treatment of certain types of cancer car cells are genetically modified immune cells engineered to recognize and kill cells with specific cancer antigen unfortunately production of genetically modified cars is problematic inefficient time consuming and therefore associated with high costs new approaches enabling production of modified immune cells more effectively faster and cheaper could therefore change the way the therapy is used within this proposal we will explore the potential of an innovative approach for production of chemically engineered immune cells and their application in immunotherapy in particular we will employ our technology based on combination of metabolic engineering and subsequent biocompatible chemical labeling to produce an antibody modified natural killer nk cells that we will investigate in cancer killing experiments we will perform a sidebyside comparison of our technology with the traditional carnk cells both in vitro and in vivo to evaluate the pros and cons of both approaches finally in collaboration with our tech transfer office we will present the technology to potential stakeholders to bring it to the next step in the form of patent licensing or eventually develop the technology further within spinout company
liver electronic offering platform with artificial intelligencebased devices

liver transplantation lt is a lifesaving procedure for decompensated cirrhosis dc and hepatocellular carcinoma hcc its efficacy is hampered by the risk of deathdropout on the wait list wl this risk is driven by organ shortage and is mitigated by organ offering schemes according to a sickest first policy offering schemes prioritize lt candidates with the highest risk of dying as assessed by predictive models to drive allocation organ sharing organizations osos use a 20yearold model the meld predicting mortality in dc but not in hcc because of a dramatic increase in of hcc candidates 40 against 10 in early 20ties meld schemes are increasingly inaccurate with persisting 15 to 30 mortality in countries with lowmedium donation rate this scenario together with advances in prognosis in dc and hcc candidates and statistics prompts lt community to look for updated algorithms to refine offering schemes to address this issue key european lt stakeholders including osos experts in lt statisticians research labs and sme joined leopard building on an innovative harmonized osos prelt dataset and advances in modeling leopard propose to design and validate 1 an aibased leopard predictive algorithm outperforming current allocation models by better stratifying patients on the risk of mortality to be proposed osos to drive allocation 2 dc hcc leopard calculators available for professional for assistance in complex decisionmaking processes 3 omicsradiomics predictive signatures integrated in a prototype 3rdgeneration exploratory model we expect to generate computational tools improving candidates outcomes with more patients transplanted on time adoption of these tools should result in harmonization of european heterogeneous prioritization schemes and in a signification reduction in disparities of access to lt a major objective pointed out by ec leopard should place europe in leading position for organ offering schemes
enhancing research on the integration of formal educational programmes and workplace learning

the project aims to enhance scientific excellence and research potential in the field of research on integrating formal education and workplace learning wpl for students in basic and secondary schools facilitating multifaceted capacity building at the school of educational sciences ses at tallinn university tlu in this field will be achieved through partnership with two internationally leading research institutions with complementary theoretical and methodological expertise finnish institute for educational research fier at the university of jyvskyl jyu and institute of educational sciences at paderborn university upbsince the emergence of industry 40 unleashed by the technological advances of the information age there is an increasing research interest in enriched learning in various authentic environments the proposed project will pay special attention to students participation in authentic work environments outside the school in the context of integrating learning at school and work previous research activities have internationally mainly focused on vocational education our project intends to widen the scope of research on this area by extending the target group and including besides vet students also students in basic education and upper secondary general educationthe projects activities involve common research activities in the area as well as various forms of knowledge sharing and communicative activities such as training guiding phd students workshops conferences common publications etcthe project will introduce novel approaches and methodologies in workplace learning research and provide new insights by applying the social ecology approach for the research in the field of integrating learning at school and at work the methodological knowledge and experiences gained will be applied in planning future international research projects within the framework of the eu research agenda
a novel handheld ultrasound medical imaging probe prototyping initial validation and business development

the lucidwave project introduces a lowcost very capable handheld ultrasound probe for medical imaging based on an entirely new ultrasound technology it aims to provide a light but powerful imaging tool to a wide range medical professionals for bedside pointofcare office and operating room diagnostics doing so it will bring the wellknown capabilities of classic ultrasound imaging closer and faster to the patient helping not only radiologists to make better decisions but also gps nurses veterinarians consequently much time costs and misdiagnosis will be saved for patient and physicianthe project has to following objectives i starting at trl 4 develop and deliver 2 full functional prototypes with all parts integrated into one slim device the capabilities will largely surpass those of current handheld devices ii validate the prototypes performance in a clinical evaluation together with the foundations of a quality management system iso 13485 it will provide a head start for a later formal clinical validation according to the new medical device regulation iii build an entrepreneurial and complementary team by inviting entrepreneursinresidence iv in preparation of a startup a complete and quantified business plan will be created building on a solid value proposition canvas incl usercentric design which is developed into a business model canvas lucidwave fits well into the eic transition programme since it aims to develop a mature proofofconcept validated against stateof art into a prototype ready for clinical validation and for scalingup of the manufacturing the technical part is complemented with a business strategy for a new and healthy startup it addresses one of the key challenges and priorities of europe ie to build a healthy society
distributed and federated crossmodality actuation through advanced nanomaterials and neuromorphic learning

a vast number of pathological brain conditions directly involve aberrant electrical activity of the brain crossbrain centres its technological revolution on the convergence of novel nanoactuation modalities bleedingedge nanoelectronics and miniaturized wireless energy harvesting and communication combining extreme edge computing with advanced nanomaterials featuring tailored physical properties biocompatible coatings and material modifications to prevent glial scarring crossbrain will enable individualized adaptive and highly spatiotemporally localized actuation of brain tissue it will leverage sensing electric local field potentials multiunit neuronal activity and crossmodal nanomaterialbased modulation electrical mechanical thermal ionic concentration optogenetics of neuronal excitability with onboard intelligence the crossbrain platform comprises a swarm of wireless implantable mricompatible microbots for in vivo electrophysiology and crossmodal neuromodulation at the cell and microcircuit levels in freely moving rodents crossbrain delivers a multiplicity of stimulation modalities involving electromechanomagnetothermooptical principles for modulation of nerve cell excitability the microbots will feature both sensing and actuation electrodes engineered with nanomaterials and viral vectors coatings they will be implanted endovascularly deliver genetic material upon command and operate in federation under the networked control and wireless power supply by a tiny central unit which can be worn like an internet of things device crossbrain will deliver autonomous or manual closedloop sensing prediction and actuation through combining multiple neuromodulation mechanisms which will act in a synergistic and dynamic manner to optimally shape stimulation according to individual neuronal firing patterns or clinicians needs as case studies we will explore crossbrain action in animal models of parkinsons disease and epilepsy
boosting photosynthetic activity via nanoparticle addition for biogas upgrading coupled with pigments production

the urgent need to reach eu independence from fossil fuel imports decarbonization and circular economy encourages the development of sustainable technologies for the production of biofuels and high addedvalue products photobiorefineries are a promising platform to produce biofuels and high addedvalue products however the low algal biomass productivities typically limit their application nanobooster will engineer a highperformance photobiorefinery based on the addition of nanoparticles nps to boost haematococcus pluvialis metabolism resulting in a biomethane that meets the en 16723 standard ch495 co22 along with enhanced astaxanthin productivities nanobooster will address two key scientific challenges the elucidation of the mechanisms of interaction between nps and microalgae and the singlestage production of astaxanthin overcoming the first challenge will allow the synthesis of tailored nps to boost h pluvialis growth and astaxanthin content then the optimal conditions of temperature light ph nps and nh4 concentration will be determined at labscale these conditions will be validated in an indoors singlestage continuous system using real centrate as a culture broth which will be pretreated via selective nh3 membrane permeation to achieve optimal nh3 concentration for astaxanthin accumulation the process will be optimized to reach an upgraded biomethane with ch4 95 and co22 and astaxanthin contents of 10 finally the process will be validated under outdoor conditions at demo scale to assess its technoeconomic feasibility and draft a business roadmap nanobooster will position photosynthetic biogas upgrading as a costeffective process easy to implement in the biogas sector the fellow dr vargas will conduct this action at the institute of sustainable processes of university of valladolid under the supervision of dr muoz with secondments at calpech and the university of almera under the supervision of dr gabriel acin
a youthcentred preventive action approach towards cocreated implementation of socially and physically activating environmental interventions

background a vast majority of teenagers do not meet guidelines for healthy movement behaviours ie physical activity sedentary behaviour and sleep posing major risks for developing multiple noncommunicable diseases ncds sustainable implementation of lifestyle interventions focused on teenagers is a key challengeaim yopaape aims to tailor implement and evaluate social and physical environmental interventions for structural improvement in the lifestyle of teenagers 1218 years in vulnerable life situations to reduce their ncd riskapproach yopaape introduces teencentred evidenceinformed cocreation to tackle the complex realworld challenge of unhealthy lifestyles and health inequalities in urban environments in hics nl dk and lmics za ng we will engage teenagers and other key stakeholders in local cocreation communities together with academic researchers and local stakeholders teenagers will take a leading role in 1 mapping the local system including needs and opportunities 2 tailoring interventions to the local context 3 implementing and 4 evaluating interventions guided by our novel superaim framework assessing local systems user perspective participatory cocreation process reach effects adoption implementation and maintenance of interventions in an integrated manner impact all results will be integrated in an open access yopaape toolbox targeted at researchers public health practitioners and authorities policy makers and citizens by establishing an infrastructure for teencentred cocreation including capacity building mentoring and participation of teenager health advocates yopaape will nurture sustainable implementation of teenagerresponsive preventive interventions tailored to the local context improving their agency movement behaviours and wellbeing ultimately halting the rise of ncds and associated healthcare costs
hybrid technologies for sustainable steel reheating

currently ng is normally substituted by hydrogen in upstream processes both blast furnace and dri or limited application in finishing lines current downstream processes totally rely on ng burning as thermal source therefore the massive usage of hydrogen in steel industry as envisioned in the carbon direct avoidance pathway of the estepeurofer masterplan requires a transformation of entire steelmaking process from liquid production process upstream to the rolling and finishing line downstream this research project is aimed at adopting hybrid heating technology based on ng with progressive and increasing h2 utilization in downstream processes thermal treatment and reheating processes which are common to both bf and eaf route have a significant ng demand about 50 nm3t of produced steel also utilization for ladle preheating has a relevant ng demand in the range 515 nm3t in order to allow the shift from ng to h2 and consequently to reduce the environmental impact by using innovative combustion technologies like flameless and oxyfuel combustion impacts on steel quality refractory and furnace must be assessed at high trl 7the general objective of this project is to exploit the hybrid heating technologies by evaluating the effects of the steel products on the refractories and also on the combustion systems three demo cases testing innovative multifuel burner and testing the limit of current systems at trl 7 will facilitate the hydrogen transition of the steel sector achieved results will bring to a co2 saving in the range 7525mtyear regarding the steel quality the project activities will individuate the optimum processing parameters to ensure that primary scale and associated scale defects do not persist through to the final product
psychiatric disorders and comorbidities caused by pollution in the mediterranean area

the psychiatric disorders and comorbidities caused by pollution in the mediterranean area psycomed project proposes a mscastaff exchange program that aims to characterise the role of anthropogenic pollutants in the mediterranean area as a risk factor of neuropsychiatric disorders and associated pathologies and the role of neuroinflammatory responses in the disease progression the consortium comprises 11 beneficiaries 8 academic 3 smes and 3 tc partners putting together complementary expertises in environmental and life sciences academics and analytical biology or natural therapeutic phytocompounds smes through a multiscale from molecular to clinical science multimodal from mechanistic to behavioural approaches and intersectoral strategy psycomed will correlate the effects of pollutants on psychiatric symptoms with alterations of inflammatory pathways in animal models and psychiatric patients we will investigate neural mechanisms underlying pathological changes in vitro and in in vivo preclinical models natural substances with therapeutic potential will be tested for their ability to restore healthy mechanisms and alleviate pathological symptoms in animal models psycomed offers a unique framework to build a network synergy by bringing together themes and scientific practises in the mediterranean area the partners will share knowledgeknowhow through secondments and workshops in support of psycomed scientific objectives this will improve the skills of staff members and their opening to the academic and private sectors by proposing common protocols and experimental design the participants will foster standardization of experimental procedures and diffusion of good laboratory practise at a global level the consortium will acquire the capacity to tackle complex neurobiological challenges while building longlasting collaborations psycomed will provide decisionmakers with the ground for public health orientations with societal impact