user: What are the symptoms of Wilson Disease ?

assistant: The signs and symptoms of Wilson disease vary, depending on what organs of the body are affected. Wilson disease is present at birth; however, the signs and symptoms of the disease do not appear until the copper builds up in the liver, the brain, or other organs.
                
When people have signs and symptoms, they usually affect the liver, the central nervous system, or both. The central nervous system includes the brain, the spinal cord, and nerves throughout the body. Sometimes a person does not have symptoms and a health care provider discovers the disease during a routine physical exam or blood test, or during an illness. Children can have Wilson disease for several years before any signs and symptoms occur. People with Wilson disease may have
                
- liver-related signs and symptoms  - central nervous system-related signs and symptoms  - mental health-related signs and symptoms  - other signs and symptoms
                
Liver-related Signs and Symptoms
                
People with Wilson disease may develop signs and symptoms of chronic, or long lasting, liver disease:
                
- weakness  - fatigue, or feeling tired  - loss of appetite  - nausea  - vomiting  - weight loss  - pain and bloating from fluid accumulating in the abdomen  - edemaswelling, usually in the legs, feet, or ankles and less often in the hands or face  - itching  - spiderlike blood vessels, called spider angiomas, near the surface of the skin  - muscle cramps  - jaundice, a condition that causes the skin and whites of the eyes to turn yellow
                
Some people with Wilson disease may not develop signs or symptoms of liver disease until they develop acute liver failurea condition that develops suddenly.
                
Central Nervous System-related Signs and Symptoms
                
Central nervous system-related symptoms usually appear in people after the liver has retained a lot of copper; however, signs and symptoms of liver disease may not be present. Central nervous system-related symptoms occur most often in adults and sometimes occur in children.1 Signs and symptoms include
                
- tremors or uncontrolled movements  - muscle stiffness  - problems with speech, swallowing, or physical coordination
                
A health care provider may refer people with these symptoms to a neurologista doctor who specializes in nervous system diseases.
                
Mental Health-related Signs and Symptoms
                
Some people will have mental health-related signs and symptoms when copper builds up in the central nervous system. Signs and symptoms may include
                
- personality changes  - depression  - feeling anxious, or nervous, about most things  - psychosiswhen a person loses contact with reality
                
Other Signs and Symptoms
                
Other signs and symptoms of Wilson disease may include
                
- anemia, a condition in which red blood cells are fewer or smaller than normal, which prevents the bodys cells from getting enough oxygen  - arthritis, a condition in which a person has pain and swelling in one or more joints  - high levels of amino acids, protein, uric acid, and carbohydrates in urine  - low platelet or white blood cell count  - osteoporosis, a condition in which the bones become less dense and more likely to fracture