Dipak-001/mistril_dataset huggingface dataset:
user: What causes Wilson Disease ?

assistant: Wilson disease is caused by an inherited autosomal recessive mutation, or change, in the ATP7B gene. In an autosomal recessive disease, the child has to inherit the gene mutation from both parents to have an increased likelihood for the disease. The chance of a child inheriting autosomal recessive mutations from both parents with a gene mutation is 25 percent, or one in four. If only one parent carries the mutated gene, the child will not get the disease, although the child may inherit one copy of the gene mutation. The child is called a carrier of the disease and can pass the gene mutation to the next generation. Genetic testing is a procedure that identifies changes in a patients genes and can show whether a parent or child is a carrier of a mutated gene. Autosomal recessive diseases are typically not seen in every generation of an affected family.
                
The following chart shows the chance of inheriting an autosomal recessive mutation from parents who both carry the mutated gene.
                

                
Genetic Diseases   Each cell contains thousands of genes that provide the instructions for making proteins for growth and repair of the body. If a gene has a mutation, the protein made by that gene may not function properly. Not all gene mutations cause a disease.   People have two copies of most genes; they inherit one copy from each parent. A genetic disease occurs when one or both parents pass a mutated gene to a child at conception. A genetic disease can also occur through a spontaneous gene mutation, meaning neither parent carries a copy of the mutated gene. Once a spontaneous gene mutation has occurred in a person, that person can pass the gene mutation on to a child.   Read more about genes and genetic conditions in the U.S. National Library of Medicines Genetics Home Reference at www.ghr.nlm.nih.gov.
user: What are the complications of Wilson Disease ?

assistant: People who have Wilson disease that is not treated or diagnosed early can have serious complications, such as
                
- cirrhosisscarring of the liver  - kidney damageas liver function decreases, the kidneys may be damaged  - persistent nervous system problems when nervous system symptoms do not resolve  - liver cancerhepatocellular carcinoma is a type of liver cancer that can occur in people with cirrhosis  - liver failurea condition in which the liver stops working properly  - death, if left untreated
user: What to do for Wilson Disease ?

assistant: People with Wilson disease should reduce their dietary copper intake by avoiding foods that are high in copper, such as
                
- shellfish  - liver  - mushrooms  - nuts  - chocolate
                
People should not eat these foods during the initial treatment and talk with the health care provider to discuss if they are safe to eat in moderation during maintenance treatment.
                
People with Wilson disease whose tap water runs through copper pipes or comes from a well should check the copper levels in the tap water. Water that sits in copper pipes may pick up copper residue, but running water lowers the level to within acceptable limits. People with Wilson disease should not use copper containers or cookware to store or prepare food or drinks.
                
To help ensure coordinated and safe care, people should discuss their use of complementary and alternative medical practices, including their use of vitamins and dietary supplements, with their health care provider. Read more at www.nccam. nih.gov/health. If the health care provider recommends taking any type of supplement or vitamin, a pharmacist can recommend types that do not contain copper.
                
People should talk with a health care provider about diet changes to reduce copper intake.
                
Liver Transplant
                
A liver transplant may be necessary in people when
                
- cirrhosis leads to liver failure  - acute liver failure happens suddenly  - treatment is not effective
                
A liver transplant is an operation to remove a diseased or an injured liver and replace it with a healthy one from another person, called a donor. A successful transplant is a life-saving treatment for people with liver failure.
                
Most liver transplants are successful. About 85 percent of transplanted livers are functioning after 1 year.2 Liver transplant surgery provides a cure for Wilson disease in most cases. More information is provided in the NIDDK health topic, Liver Transplantation.
user: How to prevent Wilson Disease ?

assistant: A person cannot prevent Wilson disease; however, people with a family history of Wilson disease, especially those with an affected sibling or parent, should talk with a health care provider about testing. A health care provider may be able to diagnose Wilson disease before symptoms appear. Early diagnosis and treatment of Wilson disease can reduce or even prevent organ damage.
                
People with a family history of the disease may also benefit from genetic testing that can identify one or more gene mutations. A health care provider may refer a person with a family history of Wilson disease to a geneticista doctor who specializes in genetic diseases.
user: What to do for Wilson Disease ?

assistant: - Wilson disease is a genetic disease that prevents the body from removing extra copper.  - Normally, the liver filters extra copper and releases it into bile. In Wilson disease, the liver does not filter copper correctly and copper builds up in the liver, brain, eyes, and other organs.  - Wilson disease is caused by an inherited autosomal recessive mutation, or change, in the ATP7B gene. In an autosomal recessive disease, the child has to inherit the gene mutation from both parents to have an increased likelihood for the disease.  - The signs and symptoms of Wilson disease vary, depending on what organs of the body are affected. People with Wilson disease may have      - liver-related signs and symptoms    - central nervous system-related signs and symptoms    - mental health-related signs and symptoms    - other signs and symptoms    - A health care provider will treat Wilson disease with a lifelong effort to reduce and control the amount of copper in the body. Treatment may include      - medications    - changes in eating, diet, and nutrition    - a liver transplant    - People with Wilson disease should reduce their dietary copper intake by avoiding foods that are high in copper, such as      - shellfish    - liver    - mushrooms    - nuts    - chocolate    - A person cannot prevent Wilson disease; however, people with a family history of Wilson disease, especially those with an affected sibling or parent, should talk with a health care provider about testing.
user: What is (are) Crohn's Disease ?

assistant: Crohn's disease is a chronic, or long lasting, disease that causes inflammationirritation or swellingin the gastrointestinal (GI) tract. Most commonly, Crohn's affects the small intestine and the beginning of the large intestine. However, the disease can affect any part of the GI tract, from the mouth to the anus.
                
Crohn's disease is a chronic inflammatory disease of the GI tract, called inflammatory bowel disease (IBD). Ulcerative colitis and microscopic colitis are the other common IBDs. More information is provided in the NIDDK health topics, Ulcerative Colitis and Microscopic Colitis: Collagenous Colitis and Lymphocytic Colitis.
                
Crohn's disease most often begins gradually and can become worse over time. Most people have periods of remissiontimes when symptoms disappearthat can last for weeks or years.
                
Some people with Crohn's disease receive care from a gastroenterologist, a doctor who specializes in digestive diseases.
user: What is (are) Crohn's Disease ?

assistant: The GI tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anusa 1-inch-long opening through which stool leaves the body. The body digests food using the movement of muscles in the GI tract, along with the release of hormones and enzymes. Organs that make up the GI tract are the mouth, esophagus, stomach, small intestine, large intestinewhich includes the appendix, cecum, colon, and rectumand anus. The last part of the GI tractcalled the lower GI tractconsists of the large intestine and anus. The intestines are sometimes called the bowel.
user: What causes Crohn's Disease ?

assistant: The exact cause of Crohn's disease is unknown. Researchers believe the following factors may play a role in causing Crohn's disease:
                
- autoimmune reaction  - genes  - environment
                
Autoimmune reaction. Scientists believe one cause of Crohn's disease may be an autoimmune reactionwhen a person's immune system attacks healthy cells in the body by mistake. Normally, the immune system protects the body from infection by identifying and destroying bacteria, viruses, and other potentially harmful foreign substances. Researchers believe bacteria or viruses can mistakenly trigger the immune system to attack the inner lining of the intestines. This immune system response causes the inflammation, leading to symptoms.
                
Genes. Crohn's disease sometimes runs in families. Research has shown that people who have a parent or sibling with Crohn's disease may be more likely to develop the disease. Researchers continue to study the link between genes and Crohn's disease.
                
Environment. Some studies suggest that certain things in the environment may increase the chance of a person getting Crohn's disease, although the overall chance is low. Nonsteroidal anti-inflammatory drugs,1 antibiotics,2 and oral contraceptives2 may slightly increase the chance of developing Crohn's disease. A high-fat diet may also slightly increase the chance of getting Crohn's disease.3
                
Some people incorrectly believe that eating certain foods, stress, or emotional distress can cause Crohn's disease. Emotional distress and eating certain foods do not cause Crohn's disease. Sometimes the stress of living with Crohn's disease can make symptoms worse. Also, some people may find that certain foods can trigger or worsen their symptoms.
user: What are the symptoms of Crohn's Disease ?

assistant: The most common signs and symptoms of Crohn's disease are
                
- diarrhea  - abdominal cramping and pain  - weight loss
                
Other general signs and symptoms include
                
- feeling tired  - nausea or loss of appetite  - fever  - anemiaa condition in which the body has fewer red blood cells than normal
                
Signs and symptoms of inflammation outside of the intestines include
                
- joint pain or soreness  - eye irritation  - skin changes that involve red, tender bumps under the skin
                
The symptoms a person experiences can vary depending on the severity of the inflammation and where it occurs.
user: What to do for Crohn's Disease ?

assistant: Researchers have not found that eating, diet, and nutrition cause Crohn's disease symptoms. Good nutrition is important in the management of Crohn's disease, however. Dietary changes can help reduce symptoms. A health care provider may recommend that a person make dietary changes such as
                
- avoiding carbonated drinks  - avoiding popcorn, vegetable skins, nuts, and other high-fiber foods  - drinking more liquids  - eating smaller meals more often  - keeping a food diary to help identify troublesome foods
                
Health care providers may recommend nutritional supplements and vitamins for people who do not absorb enough nutrients.
                
To help ensure coordinated and safe care, people should discuss their use of complementary and alternative medical practices, including their use of dietary supplements and probiotics, with their health care provider. Read more at www.nccam.nih.gov/health/probiotics.
                
Depending on a person's symptoms or medications, a health care provider may recommend a specific diet, such as a
                
- high-calorie diet  - lactose-free diet  - low-fat diet  - low-fiber diet  - low-salt diet
                
People should speak with a health care provider about specific dietary recommendations and changes.
user: What are the complications of Crohn's Disease ?

assistant: Complications of Crohn's disease can include
                
- bowel obstruction. Crohn's disease can thicken the wall of the intestine. Over time, the thickened areas of the intestine can narrow, which can block the intestine. A partial or complete obstruction, also called a bowel blockage, can block the movement of food or stool through the intestines. A complete bowel obstruction is life threatening and requires immediate medical attention and often surgery.  - fistulasabnormal passages, or tunnels, between two organs, or between an organ and the outside of the body. How a health care provider treats fistulas depends on their type and severity. For some people, fistulas heal with medication and diet changes, while other people will need to have surgery.  - anal fissuressmall tears in the anus that may cause itching, pain, or bleeding. Most anal fissures heal with medical treatment, including ointments, warm baths, and dietary changes.  - ulcers. Inflammation anywhere along the GI tract can lead to ulcers or open sores in a person's mouth, intestines, anus, and perineumthe area between the anus and the sex organs. In most cases, the treatment a health care provider prescribes for Crohn's disease will also treat the ulcers.  - malnutritiona condition that develops when the body does not get the right amount of vitamins, minerals, and nutrients it needs to maintain healthy tissues and organ function. Some people may need IV fluids or feeding tubes to replace lost nutrients and fluids.  - inflammation in other areas of the body. The immune system can trigger inflammation in the      - joints    - eyes    - skin
                
Health care providers can treat inflammation by adjusting medications or prescribing new medications.
                

                
Crohn's Disease and Colon Cancer   People with Crohn's disease in the large intestine may be more likely to develop colon cancer. People who receive ongoing treatment and remain in remission may reduce their chances of developing colon cancer.   People with Crohn's disease should talk with their health care provider about how often they should get screened for colon cancer. Screening can include colonoscopy with biopsies. Such screening does not reduce a person's chances of developing colon cancer. Instead, screening can help diagnose cancer early and improve chances for recovery.
user: What to do for Crohn's Disease ?

assistant: - Crohn's disease is a chronic, or long lasting, disease that causes inflammationirritation or swellingin the gastrointestinal (GI) tract.  - The exact cause of Crohn's disease is unknown. Researchers believe that factors such as an autoimmune reaction, genes, and environment may play a role in causing Crohn's disease.  - Crohn's disease can occur in people of any age. However, it is more likely to develop in people      - between the ages of 20 and 29    - who have a family member, most often a sibling or parent, with inflammatory bowel disease (IBD)    - who smoke cigarettes    - The most common signs and symptoms of Crohn's disease are diarrhea, abdominal cramping and pain, and weight loss.  - A health care provider diagnoses Crohn's disease with the following:      - medical and family history    - physical exam    - lab tests    - upper GI series    - computerized tomography (CT) scan    - intestinal endoscopy    - Which treatment a person needs depends on the severity of the disease and symptoms.  - Good nutrition is important in the management of Crohn's disease. A health care provider may recommend that a person make dietary changes.  - People with Crohn's disease should talk with their health care provider about how often they should get screened for colon cancer.
user: What is (are) What I need to know about Kidney Stones ?

assistant: A kidney* stone is a solid piece of material that forms in a kidney when there are high levels of certain substances in the urine. These substances are normally found in the urine and do not cause problems at lower levels.
                
A stone may stay in the kidney or travel down the urinary tract. Kidney stones vary in size. A small stone may pass on its own, causing little or no pain. A larger stone may get stuck along the urinary tract. A stone that gets stuck can block the flow of urine, causing severe pain or bleeding.
                
*See the Pronunciation Guide for tips on how to say the words in bold.
user: What is (are) What I need to know about Kidney Stones ?

assistant: The urinary tract is the bodys drainage system for removing wastes and extra water. The urinary tract includes two kidneys, two ureters, a bladder, and a urethra. The kidneys are two bean-shaped organs, each about the size of a fist. They are located near the middle of the back, just below the rib cage, one on each side of the spine. Every day, the two kidneys process about 200 quarts of blood to produce about 1 to 2 quarts of urine, composed of wastes and extra water. The urine flows from the kidneys to the bladder through tubes called ureters.
                
The bladder stores urine until releasing it through urination. When the bladder empties, urine flows out of the body through a tube called the urethra at the bottom of the bladder.
user: What causes What I need to know about Kidney Stones ?

assistant: Kidney stones are caused by high levels of calcium, oxalate, and phosphorus in the urine. Some foods may cause kidney stones in certain people. You may be more likely to get a kidney stone if you have
                
- a condition that affects levels of substances in your urine that can cause stones to form  - a family history of kidney stones  - repeating, or recurrent, urinary tract infections  - blockage of your urinary tract  - digestive problems
                
You may also be more likely to get a kidney stone if you dont drink enough fluids or if you take certain medicines.
user: What is (are) What I need to know about Kidney Stones ?

assistant: Doctors have found four main types of kidney stones:
                
- The most common types of stones contain calcium. Calcium is a normal part of a healthy diet. Calcium that is not used by the bones and muscles goes to the kidneys. In most people, the kidneys flush out the extra calcium with the rest of the urine. People who have calcium stones keep the calcium in their kidneys. The calcium that stays behind joins with other waste products to form a stone. People can have calcium oxalate and calcium phosphate stones. Calcium oxalate stones are more common.  - A uric acid stone may form when the urine contains too much acid. People who eat a lot of meat, fish, and shellfish may get uric acid stones.  - A struvite stone may form after you have a kidney infection.  - Cystine stones result from a genetic disorder, meaning a problem passed from parent to child. The disorder causes cystine to leak through the kidneys and into the urine.
user: What are the symptoms of What I need to know about Kidney Stones ?

assistant: You may have a kidney stone if you
                
- have pain while urinating  - see blood in your urine  - feel a sharp pain in your back or lower abdomenthe area between your chest and hips
                
The pain may last for a short or long time. You may have nausea and vomiting with the pain.
                
If you have a small stone that passes on its own easily, you may not have symptoms at all.
user: How to diagnose What I need to know about Kidney Stones ?

assistant: To diagnose kidney stones, your doctor will do a physical exam and ask about your medical history. The doctor may ask if you have a family history of kidney stones and about your diet, digestive problems, and other health problems. The doctor may perform urine, blood, and imaging tests to complete the diagnosis.
                
- Urine tests can show whether you have an infection or your urine contains substances that form stones.  - Blood tests can show problems that lead to kidney stones.  - Imaging tests are used to find the location of kidney stones in your body. The tests may also be able to show problems that caused a kidney stone to form.
user: What are the treatments for What I need to know about Kidney Stones ?

assistant: The treatment for kidney stones usually depends on their size and what they are made of. Kidney stones may be treated by your regular doctor or by a urologista doctor who specializes in the urinary tract. You may need treatment if you have symptoms or if a kidney stone is blocking your urinary tract. Small stones dont usually need treatment. Still, you may need pain medicine. You should also drink lots of fluids to help move the stone along. If you are vomiting often or dont drink enough fluids, you may need to go to the hospital and get fluids through a needle in your arm.
                
If you have a large kidney stone or your urinary tract is blocked, the urologist can remove the stone or break it into small pieces with the following treatments:
user: How to prevent What I need to know about Kidney Stones ?

assistant: To prevent kidney stones, you need to know what caused your kidney stone. Your doctor may ask you to try to catch the kidney stone as it passes in your urine. The kidney stone can then be sent to a lab to find out what type of stone it is. If you have treatment in the hospital and the doctor removes the stone, it will also be sent to a lab for testing.
                
Your doctor may ask you to collect your urine for 24 hours after the stone has passed or been removed. Your doctor can then measure how much urine you produce in a day and mineral levels in the urine. You are more likely to form stones if you dont make enough urine each day or have a problem with mineral levels.
                
Once you know what type of kidney stone you had, you can make changes in your eating, diet, and nutrition and take medicines to prevent future kidney stones.
user: What to do for What I need to know about Kidney Stones ?

assistant: You can help prevent kidney stones by making changes in how much you consume of the following:
                
- fluids  - sodium  - animal protein  - calcium  - oxalate
                
Drinking enough fluids each day is the best way to help prevent most types of kidney stones. You should drink 2 to 3 liters of fluid a day. If you had cystine stones, you may need to drink even more.
                
Though water is best, other fluids may also help prevent kidney stones, such as orange juice or lemonade. Talk with your health care provider if you cant drink the recommended amount due to other health problems, such as urinary incontinence, urinary frequency, or kidney failure.
                
You can make the following changes to your diet based on the type of kidney stone you had:
                
Calcium Oxalate Stones
                
- reduce sodium  - reduce animal protein, such as meat, eggs, and fish  - get enough calcium from food or take calcium supplements with food  - avoid foods high in oxalate, such as spinach, rhubarb, nuts, and wheat bran
                
Calcium Phosphate Stones
                
- reduce sodium  - reduce animal protein  - get enough calcium from food or take calcium supplements with food
                
Uric Acid Stones
                
- limit animal protein
                
More information about how changes in diet affect kidney stone formation is provided in the NIDDK health topic, Diet for Kidney Stone Prevention.
                

                
Medicines
                
Your doctor may prescribe medicines based on the type of kidney stone you had and any health problems you have that make you more likely to form a stone.