Dipak-001/mistril_dataset huggingface dataset:
user: What are the symptoms of Angina ?

assistant: Pain and discomfort are the main symptoms of angina. Angina often is described as pressure, squeezing, burning, or tightness in the chest. The pain or discomfort usually starts behind the breastbone.
                
Pain from angina also can occur in the arms, shoulders, neck, jaw, throat, or back. The pain may feel like indigestion. Some people say that angina pain is hard to describe or that they can't tell exactly where the pain is coming from.
                
Signs and symptoms such as nausea (feeling sick to your stomach), fatigue (tiredness), shortness of breath, sweating, light-headedness, and weakness also may occur.
                
Women are more likely to feel discomfort in the neck, jaw, throat, abdomen, or back. Shortness of breath is more common in older people and those who have diabetes. Weakness, dizziness, and confusion can mask the signs and symptoms of angina in elderly people.
                
Symptoms also vary based on the type of angina you have.
                
Because angina has so many possible symptoms and causes, all chest pain should be checked by a doctor. Chest pain that lasts longer than a few minutes and isn't relieved by rest or angina medicine may be a sign of a heart attack. Call 911 right away.
                
Stable Angina
                
The pain or discomfort:
                
Occurs when the heart must work harder, usually during physical exertion
                
Doesn't come as a surprise, and episodes of pain tend to be alike
                
Usually lasts a short time (5 minutes or less)
                
Is relieved by rest or medicine
                
May feel like gas or indigestion
                
May feel like chest pain that spreads to the arms, back, or other areas
                
Unstable Angina
                
The pain or discomfort:
                
Often occurs at rest, while sleeping at night, or with little physical exertion
                
Comes as a surprise
                
Is more severe and lasts longer than stable angina (as long as 30 minutes)
                
Usually isnt relieved by rest or medicine
                
May get worse over time
                
May mean that a heart attack will happen soon
                
Variant Angina
                
The pain or discomfort:
                
Usually occurs at rest and during the night or early morning hours
                
Tends to be severe
                
Is relieved by medicine
                
Microvascular Angina
                
The pain or discomfort:
                
May be more severe and last longer than other types of angina pain
                
May occur with shortness of breath, sleep problems, fatigue, and lack of energy
                
Often is first noticed during routine daily activities and times of mental stress
user: How to prevent Angina ?

assistant: You can prevent or lower your risk for angina and heart disease by making lifestyle changes and treating related conditions.
                
Making Lifestyle Changes
                
Healthy lifestyle choices can help prevent or delay angina and heart disease. To adopt a healthy lifestyle, you can:
                
Quit smoking and avoid secondhand smoke
                
Avoid angina triggers
                
Follow a healthy diet
                
Be physically active
                
Maintain a healthy weight
                
Learn ways to handle stress and relax
                
Take your medicines as your doctor prescribes
                
For more information about these lifestyle changes, go to How Is Angina Treated? For more information about preventing and controlling heart disease risk factors, visit the Diseases and Conditions Index Coronary Heart Disease, Coronary Heart Disease Risk Factors, and Coronary Microvascular Disease articles.
                
Treating Related Conditions
                
You also can help prevent or delay angina and heart disease by treating related conditions, such as high blood cholesterol, high blood pressure, diabetes, and overweight or obesity.
                
If you have one or more of these conditions, talk with your doctor about how to control them. Follow your treatment plan and take all of your medicines as your doctor prescribes.
user: What is (are) Heart Failure ?

assistant: Heart failure is a condition in which the heart can't pump enough blood to meet the body's needs. In some cases, the heart can't fill with enough blood. In other cases, the heart can't pump blood to the rest of the body with enough force. Some people have both problems.
                
The term "heart failure" doesn't mean that your heart has stopped or is about to stop working. However, heart failure is a serious condition that requires medical care.
                
Overview
                
Heart failure develops over time as the heart's pumping action grows weaker. The condition can affect the right side of the heart only, or it can affect both sides of the heart. Most cases involve both sides of the heart.
                
Right-side heart failure occurs if the heart can't pump enough blood to the lungs to pick up oxygen. Left-side heart failure occurs if the heart can't pump enough oxygen-rich blood to the rest of the body.
                
Right-side heart failure may cause fluid to build up in the feet, ankles, legs, liver, abdomen, and the veins in the neck. Right-side and left-side heart failure also may cause shortness of breath and fatigue (tiredness).
                
The leading causes of heart failure are diseases that damage the heart. Examples include coronary heart disease (CHD), high blood pressure, and diabetes.
                
Outlook
                
Heart failure is a very common condition. About 5.7 million people in the United States have heart failure.Both children and adults can have the condition, although the symptoms and treatments differ. The Health Topicfocuses on heart failure in adults.
                
Currently, heart failure has no cure. However, treatmentssuch as medicines and lifestyle changescan help people who have the condition live longer and more active lives. Researchers continue to study new ways to treat heart failure and its complications.
user: Who is at risk for Heart Failure? ?

assistant: About 5.7 million people in the United States have heart failure. The number of people who have this condition is growing.
                
Heart failure is more common in:
                
People who are age 65 or older. Aging can weaken the heart muscle. Older people also may have had diseases for many years that led to heart failure. Heart failure is a leading cause of hospital stays among people on Medicare.
                
Blacks are more likely to have heart failure than people of other races. Theyre also more likely to have symptoms at a younger age, have more hospital visits due to heart failure, and die from heart failure.
                
People who areoverweight. Excess weight puts strain on the heart. Being overweight also increases your risk of heart disease and type 2diabetes. These diseases can lead to heart failure.
                
People who have had a heart attack. Damage to the heart muscle from a heart attack and can weaken the heart muscle.
                
Children who havecongenital heart defectsalso can develop heart failure. These defects occur if the heart, heart valves, or blood vessels near the heart dont form correctly while a baby is in the womb. Congenital heart defects can make the heart work harder. This weakens the heart muscle, which can lead to heart failure. Children dont have the same symptoms of heart failure or get the same treatments as adults. This Health Topic focuses on heart failure in adults.
user: What are the symptoms of Heart Failure ?

assistant: The most common signs and symptoms of heart failure are:
                
Shortness of breath or trouble breathing
                
Fatigue (tiredness)
                
Swelling in the ankles, feet, legs, abdomen, and veins in the neck
                
All of these symptoms are the result of fluid buildup in your body. When symptoms start, you may feel tired and short of breath after routine physical effort, like climbing stairs.
                
As your heart grows weaker, symptoms get worse. You may begin to feel tired and short of breath after getting dressed or walking across the room. Some people have shortness of breath while lying flat.
                
Fluid buildup from heart failure also causes weight gain, frequent urination, and a cough that's worse at night and when you're lying down. This cough may be a sign of acute pulmonary edema (e-DE-ma). This is a condition in which too much fluid builds up in your lungs. The condition requires emergency treatment.
                
Heart Failure Signs and Symptoms
user: How to prevent Heart Failure ?

assistant: You can take steps to prevent heart failure. The sooner you start, the better your chances of preventing or delaying the condition.
                
For People Who Have Healthy Hearts
                
If you have a healthy heart, you can take action to prevent heart disease and heart failure. To reduce your risk of heart disease:
                
Avoid using illegal drugs.
                
Be physically active. The more active you are, the more you will benefit.
                
Follow a heart-healthy eating plan.
                
If yousmoke, make an effort to quit. Talk with your doctor about programs and products that can help you quit smoking. Also, try to avoid secondhand smoke.
                
Maintain a healthy weight. Work with your health care team to create a reasonable weight-loss plan.
                
For People Who Are at High Risk for Heart Failure
                
Even if youre at high risk for heart failure, you can take steps to reduce your risk. People at high risk include those who have coronary heart disease,high blood pressure, ordiabetes.
                
Follow all of the steps listed above. Talk with your doctor about what types and amounts of physical activity are safe for you.
                
Treat and control any conditions that can cause heart failure. Take medicines as your doctor prescribes.
                
Avoid drinking alcohol.
                
See your doctor for ongoing care.
                
For People Who Have Heart Damage but No Signs of Heart Failure
                
If you have heart damage but no signs of heart failure, you can still reduce your risk of developing the condition. In addition to the steps above, take your medicines as prescribed to reduce your hearts workload.
user: What is (are) Thrombocythemia and Thrombocytosis ?

assistant: Thrombocythemia (THROM-bo-si-THE-me-ah) and thrombocytosis (THROM-bo-si-TO-sis) are conditions in which your blood has a higher than normal number of platelets (PLATE-lets).
                
Platelets are blood cell fragments. They're made in your bone marrow along with other kinds of blood cells.
                
Platelets travel through your blood vessels and stick together (clot). Clotting helps stop any bleeding that may occur if a blood vessel is damaged. Platelets also are called thrombocytes (THROM-bo-sites) because a blood clot also is called a thrombus.
                
A normal platelet count ranges from 150,000 to 450,000 platelets per microliter of blood.
                
Overview
                
The term "thrombocythemia" is preferred when the cause of a high platelet count isn't known. The condition sometimes is called primary or essential thrombocythemia.
                
This condition occurs if faulty cells in the bone marrow make too many platelets. Bone marrow is the sponge-like tissue inside the bones. It contains stem cells that develop into red blood cells, white blood cells, and platelets. What causes the bone marrow to make too many platelets often isn't known.
                
With primary thrombocythemia, a high platelet count may occur alone or with other blood cell disorders. This condition isn't common.
                
When another disease or condition causes a high platelet count, the term "thrombocytosis" is preferred. This condition often is called secondary or reactive thrombocytosis. Secondary thrombocytosis is more common than primary thrombocythemia.
                
Often, a high platelet count doesn't cause signs or symptoms. Rarely, serious or life-threatening symptoms can develop, such as blood clots and bleeding. These symptoms are more likely to occur in people who have primary thrombocythemia.
                
Outlook
                
People who have primary thrombocythemia with no signs or symptoms don't need treatment, as long as the condition remains stable.
                
Other people who have this condition may need medicines or procedures to treat it. Most people who have primary thrombocythemia will live a normal lifespan.
                
Treatment and outlook for secondary thrombocytosis depend on its underlying cause.
user: What causes Thrombocythemia and Thrombocytosis ?

assistant: Primary Thrombocythemia
                
In this condition, faulty stem cells in the bone marrow make too many platelets. What causes this to happen usually isn't known. When this process occurs without other blood cell disorders, it's called essential thrombocythemia.
                
A rare form of thrombocythemia is inherited. ("Inherited" means the condition is passed from parents to children through the genes.) In some cases, a genetic mutation may cause the condition.
                
In addition to the bone marrow making too many platelets, the platelets also are abnormal in primary thrombocythemia. They may form blood clots or, surprisingly, cause bleeding when they don't work well.
                
Bleeding also can occur because of a condition that develops called von Willebrand disease. This condition affects the blood clotting process.
                
After many years, scarring of the bone marrow can occur.
                
Secondary Thrombocytosis
                
This condition occurs if another disease, condition, or outside factor causes the platelet count to rise. For example, 35 percent of people who have high platelet counts also have cancermostly lung, gastrointestinal, breast, ovarian, and lymphoma. Sometimes a high platelet count is the first sign of cancer.
                
Other conditions or factors that can cause a high platelet count are:
                
Iron-deficiency anemia (uh-NEE-me-uh)
                
Hemolytic (HEE-moh-lit-ick) anemia
                
Absence of a spleen (after surgery to remove the organ)
                
Inflammatory or infectious diseases, such as connective tissue disorders, inflammatory bowel disease, and tuberculosis
                
Reactions to medicine
                
Some conditions can lead to a high platelet count that lasts for only a short time. Examples of such conditions include:
                
Recovery from serious blood loss
                
Recovery from a very low platelet count caused by excessive alcohol use and lack of vitamin B12 or folate
                
Acute (short-term) infection or inflammation
                
Response to physical activity
                
Although the platelet count is high in secondary thrombocytosis, the platelets are normal (unlike in primary thrombocythemia). Thus, people who have secondary thrombocytosis have a lower risk of blood clots and bleeding.
user: Who is at risk for Thrombocythemia and Thrombocytosis? ?

assistant: Primary Thrombocythemia
                
Thrombocythemia isn't common. The exact number of people who have the condition isn't known. Some estimates suggest that 24 out of every 100,000 people have primary thrombocythemia.
                
Primary thrombocythemia is more common in people aged 50 to 70, but it can occur at any age. For unknown reasons, more women around the age of 30 have primary thrombocythemia than men of the same age.
                
Secondary Thrombocytosis
                
You might be at risk for secondary thrombocytosis if you have a disease, condition, or factor that can cause it. (For more information, go to "What Causes Thrombocythemia and Thrombocytosis?")
                
Secondary thrombocytosis is more common than primary thrombocythemia. Studies have shown that most people who have platelet counts over 500,000 have secondary thrombocytosis.
user: What are the symptoms of Thrombocythemia and Thrombocytosis ?

assistant: People who have thrombocythemia or thrombocytosis may not have signs or symptoms. These conditions might be discovered only after routine blood tests.
                
However, people who have primary thrombocythemia are more likely than those who have secondary thrombocytosis to have serious signs and symptoms.
                
The signs and symptoms of a high platelet count are linked to blood clots and bleeding. They include weakness, bleeding, headache, dizziness, chest pain, and tingling in the hands and feet.
                
Blood Clots
                
In primary thrombocythemia, blood clots most often develop in the brain, hands, and feet. But they can develop anywhere in the body, including in the heart and intestines.
                
Blood clots in the brain may cause symptoms such as chronic (ongoing) headache and dizziness. In extreme cases, stroke may occur.
                
Blood clots in the tiny blood vessels of the hands and feet leave them numb and red. This may lead to an intense burning and throbbing pain felt mainly on the palms of the hands and the soles of the feet.
                
Other signs and symptoms of blood clots may include:
                
Changes in speech or awareness, ranging from confusion to passing out
                
Seizures
                
Upper body discomfort in one or both arms, the back, neck, jaw, or abdomen
                
Shortness of breath and nausea (feeling sick to your stomach)
                
In pregnant women, blood clots in the placenta can cause miscarriage or problems with fetal growth and development.
                
Women who have primary thrombocythemia or secondary thrombocytosis and take birth control pills are at increased risk for blood clots.
                
Blood clots are related to other conditions and factors as well. Older age, prior blood clots, diabetes, high blood pressure, and smoking also increase your risk for blood clots.
                
Bleeding
                
If bleeding occurs, it most often affects people who have platelet counts higher than 1million platelets per microliter of blood. Signs of bleeding include nosebleeds, bruising, bleeding from the mouth or gums, or blood in the stools.
                
Although bleeding usually is associated with a low platelet count, it also can occur in people who have high platelet counts. Blood clots that develop in thrombocythemia or thrombocytosis may use up your body's platelets. This means that not enough platelets are left in your bloodstream to seal off cuts or breaks on the blood vessel walls.
                
Another cause of bleeding in people who have very high platelets counts is a condition called von Willebrand Disease. This condition affects the blood clotting process.
                
In rare cases of primary thrombocythemia, the faulty bone marrow cells will cause a form of leukemia (lu-KE-me-ah). Leukemia is a cancer of the blood cells.
user: How to prevent Thrombocythemia and Thrombocytosis ?

assistant: You can't prevent primary thrombocythemia. However, you can take steps to reduce your risk for complications. For example, you can control many of the risk factors for blood clots, such as high blood cholesterol, high blood pressure, diabetes, and smoking.
                
To reduce your risk, quit smoking, adopt healthy lifestyle habits, and work with your doctor to manage your risk factors.
                
It's not always possible to prevent conditions that lead to secondary thrombocytosis. But, if you have routine medical care, your doctor may detect these conditions before you develop a high platelet count.
user: What causes Thrombotic Thrombocytopenic Purpura ?

assistant: A lack of activity in the ADAMTS13 enzyme (a type of protein in the blood) causes thrombotic thrombocytopenic purpura (TTP). The ADAMTS13 gene controls the enzyme, which is involved in blood clotting.
                
Not having enough enzyme activity causes overactive blood clotting. In TTP, blood clots form in small blood vessels throughout the body. These clots can limit or block the flow of oxygen-rich blood to the body's organs, such as the brain, kidneys, and heart. As a result, serious health problems can develop.
                
The increased clotting that occurs in TTP also uses up many of the blood's platelets. With fewer platelets available in the blood, bleeding problems can occur.
                
People who have TTP may bleed inside their bodies, underneath the skin, or from the surface of the skin. When cut or injured, they also may bleed longer than normal.
                
TTP also can cause red blood cells to break apart faster than the body can replace them. This leads to hemolytic anemia.
                
Inherited Thrombotic Thrombocytopenic Purpura
                
In inherited TTP, the ADAMTS13 gene is faulty. It doesn't prompt the body to make a normal ADAMTS13 enzyme. As a result, enzyme activity is lacking or changed.
                
"Inherited" means that the condition is passed from parents to children through genes. A person who inherits TTP is born with two copies of the faulty geneone from each parent.
                
Most often, the parents each have one copy of the faulty gene, but have no signs or symptoms TTP.
                
Acquired Thrombotic Thrombocytopenic Purpura
                
In acquired TTP, the ADAMTS13 gene isn't faulty. Instead, the body makes antibodies (proteins) that block the activity of the ADAMTS13 enzyme.
                
"Acquired" means you aren't born with the condition, but you develop it sometime after birth.
                
Triggers for Thrombotic Thrombocytopenic Purpura
                
It's unclear what triggers inherited and acquired TTP, but some factors may play a role. These factors may include:
                
Some diseases and conditions, such as pregnancy, cancer, HIV, lupus, and infections
                
Some medical procedures, such as surgery and blood and marrow stem cell transplant
                
Some medicines, such as chemotherapy, ticlopidine, clopidogrel, cyclosporine A, and hormone therapy and estrogens
                
Quinine, which is a substance often found in tonic water and nutritional health products
user: Who is at risk for Thrombotic Thrombocytopenic Purpura? ?

assistant: Thrombotic thrombocytopenic purpura (TTP) is a rare disorder. Most cases of TTP are acquired. Acquired TTP mostly occurs in adults, but it can affect children. The condition occurs more often in women and in Black people than in other groups.
                
Inherited TTP mainly affects newborns and children. Most people who have inherited TTP begin to have symptoms soon after birth. Some, however, don't have symptoms until they're adults.
                
It isn't clear what triggers inherited and acquired TTP, but some factors may play a role. These factors may include:
                
Some diseases and conditions, such as pregnancy, cancer, HIV, lupus, and infections
                
Some medical procedures, such as surgery and blood and marrow stem cell transplant
                
Some medicines, such as chemotherapy, ticlopidine, clopidogrel, cyclosporine A, and hormone therapy and estrogens
                
Quinine, which is a substance often found in tonic water and nutritional health products