Hypothermia to treat neonatal hypoxic ischemic encephalopathy: systematic review.

To systematically review the effectiveness, as determined by survival without moderate to severe neurodevelopmental disability in infancy and childhood, and the safety of hypothermia vs normothermia in neonates with postintrapartum hypoxic-ischemic encephalopathy and to perform subgroup analyses based on severity of encephalopathy (moderate or severe), type of hypothermia (systemic or selective head cooling), and degree of hypothermia (moderate [<or=32.0-33.5 degrees C] or mild [>or=33.6 degrees C]).