Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults.

Some antiepileptic drugs but not others are useful in clinical practice for the prophylaxis of migraine. This might be explained by the variety of actions of these drugs in the central nervous system. The present review is part of an update of a Cochrane review first published in 2004, and previously updated (conclusions not changed) in 2007.