Interventions involving a major dietary component improve cognitive function in cognitively healthy adults: a systematic review and meta-analysis.

Accumulating evidence suggests a role for diet in promoting brain health. The purpose of this systematic review was to (1) quantitatively assess whether interventions with a major dietary component can enhance cognition in cognitively healthy adults and (2) identify responsive domains of cognition to inform the design of future dietary trials. Electronic databases were systematically searched to find eligible randomized controlled trials that assessed the effect of interventions with a major dietary component on cognitive function or incident dementia in adults without known cognitive impairment. Standardized mean differences (SMDs) (95% confidence interval [CI]) were combined using a random-effects meta-analysis, and tests of homogeneity of variance were calculated. Two trials reported dementia outcomes and were qualitatively described. Fifteen trials encompassing 6480 participants were eligible for meta-analysis. Compared to control, intervention improved performance on measures of global cognition (SMD = 0.14, 95% CI 0.01-0.27, P = .05, I