Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : cenRNA (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Life Science
Panel : Molecules of Life: Biological Mechanisms, Structures and Functions
Entité participante : Heidelberg University — Pays : Allemagne — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1896250.0 €

One of the most astonishing processes in the life of a cell is the division into two daughter cells. Such a highly organized process would presumably be regulated tightly by the underlying centromeric DNA sequence; however, the sites of chromosome attachment to the microtubule spindle are regulated by epigenetic mechanisms. The best-characterized epigenetic mark for centromeres is the histone H3-variant CENP-A, which replaces H3 in some of the nucleosomes within centromeric chromatin. Centromeres are embedded in pericentromeric heterochromatin and it has become apparent in recent years that heterochromatin is transcribed into non-coding RNAs. We have recently shown that a long non-coding RNA from pericentromeric heterochromatin of the X chromosome (SATIII) in Drosophila melanogaster localizes in trans to centromeres of all other chromosomes and is an essential component for correct loading and maintenance of CENP-A and, therefore, genome stability. Additional RNAs in Drosophila and RNAs from other species have been linked to centromeric chromatin, but their function is not understood. We propose that a complex, RNA-based epigenetic mechanism regulates centromere establishment and function. This proposal is designed to the precise function of SATIII RNA by identifying the associated protein complexes as well as structural and post-transcriptional features of SATIII. We will evaluate the mechanisms by which SATIII functions as a heritable mark of centromeres through generations, during the developing germ line, and species separation. In parallel, we will systematically identify and characterize centromere-associated RNAs (cenRNAs) in Drosophila and human cells. We will elucidate their function in centromere biology and chromosome segregation, essentially as we have done and propose to do for SATIII. These experiments are designed to provide a detailed understanding of the essential, RNA-based epigenetic regulation of centromeres.

Mots-clés : centromeres,non coding rna,heterochromatin
Projet ERC : ACROSS (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Southampton — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 826652.06 €

One of the most exciting research questions within archaeology is that of the peopling of Australasia by at least c.50,000 years ago. This represents some of the earliest evidence of modern human colonization outside Africa, yet, even at the greatest sea-level lowstand, this migration would have involved seafaring. It is the maritime nature of this dispersal which makes it so important to questions of technological, cognitive and social human development. These issues have traditionally been the preserve of archaeologists, but with a multidisciplinary approach that embraces cutting-edge marine geophysical, hydrodynamic and archaeogenetic analyses, we now have the opportunity to examine the When, Where, Who and How of the earliest seafaring in world history. The voyage from Sunda (South East Asia) to Sahul (Australasia) provides evidence for the earliest ‘open water’ crossing in the world. A combination of the sparse number of early archaeological finds and the significant changes in the palaeolandscape and submergence of the broad north western Australian continental shelf, mean that little is known about the routes taken and what these crossings may have entailed. This project will combine research of the submerged palaeolandscape of the continental shelf to refine our knowledge of the onshore/offshore environment, identify potential submerged prehistoric sites and enhance our understanding of the palaeoshoreline and tidal regime. This will be combined with archaeogenetic research targeting mtDNA and Y-chromosome data to resolve questions of demography and dating. For the first time this project takes a truly multidisciplinary approach to address the colonization of Sahul, providing an unique opportunity to tackle some of the most important questions about human origins, the relationship between humans and the changing environment, population dynamics and migration, seafaring technology, social organisation and cognition.

Mots-clés : marine,maritime,palaeolandscape,seafaring,migration
Projet ERC : TOPONANOP (Horizon 2020, appel 2016, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Institute of Photonic Sciences — Pays : Espagne — Rôle : PI
Acronyme de l'entité : ICFO;ICFO-CERCA
Type d'entité : Recherche
Financement ERC de l'entité : 2748437.0 €

One of the most fascinating phenomena in nature is the interplay between quantum mechanics and the flow of electrons in solids. A tangible example is the quantum hall effect, where electrons flow with virtually zero dissipation. That is because electrons can flow only in one direction, which makes them move around objects without scattering, representing robustness by topological protection. Essential for this effect is the magnetic field that breaks time-reversal symmetry. Recently, however, with the advent of novel exotic quantum materials, completely new concepts for topological and non-reciprocal phenomena have appeared on the horizon, without the need to apply any magnetic field. These materials exhibit intrinsic topological character due to quantum mechanical interferences. TOPONANOP’s vision is to exploit these extraordinary quantum properties in order to control light at the nanoscale in a radically new way. One of the main objectives is to generate nanoscale optical fields (plasmons) that propagate in only one direction and implement topologically protected plasmons such that they move around defects and corners. At the same time, visualizing and controlling electromagnetic excitations will be used as a tool to unravel extraordinary phenomena in exotic quantum materials. To this end, TOPONANOP will apply novel low-temperature, THz and infrared, near-field imaging and spectroscopy techniques to directly spatially visualize the plasmon non-reciprocity and topological character. Topological nano-photonics is a new paradigm for novel quantum materials and will enable novel future applications in miniaturized photonic isolators, diodes and logic circuits and could lead to completely new concepts for communication systems, optical transistors and optical information processing.
Projet ERC : TURNSTONE (Horizon 2020, appel 2019, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Technical University of Denmark — Pays : Danemark — Rôle : PI
Acronyme de l'entité : DTU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1874669.0 €

One of the most important outstanding questions in physics is arguably the understanding of correlated electrons in condensed matter. The theoretical framework is given by the Hubbard model, however, no analytical solutions have been found and numerical treatments are challenging and controversial. Although great progress has been made in experimental implementations of the Hubbard model in cold atom lattices and ion traps, the most interesting regime of low temperature and strong interactions, presumably accounting for the physics of High-Tc superconductors, is yet to be realized. In this project a new experimental platform is proposed for realizing tunable lattices of coupled quantum dots (QDs) by combining Molecular Beam Epitaxy crystal growth of semiconductor nanostructures, state-of-the-art semiconductor processing, and low-temperatures quantum transport. Macroscopic networks of ultra-high quality InAs nanowires will be combined with epitaxial integration of dielectric layers and gate metals. The gates thereby retain the ultimate limit of uniformity; overcoming previous problems with QD arrays. Conservative estimates of the on-site Coulomb interaction ~100-200Kelvin and with fully gate-tunable tunnel couplings, the strongly interacting, low-T regime is easily reachable. Both square and honeycomb lattices will be realized and the macroscopic properties will studied by transport and quantum capacitance spectroscopy at mK temperatures, and in addition, the currents will be locally probed by scanning SQUID microscopy. Furthermore, by a new concept for gating, we achieve tunable spatial modulation of tunnel couplings, and thereby enable in situ tunable gauge fields, tunable disorder, and controlled symmetry breaking. A proof-of-concept experiment is discussed. If successful, the results will have major impact on physics, technology and material science by providing a tunable model of the foundation of solid state physics.

Mots-clés : mbe growth of semiconductor nanostructures,low temperature transport,quantum dot lattices
Projet ERC : SMIC (Horizon 2020, appel 2019, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Human Mind and Its Complexity
Entité participante : Centre national de la recherche scientifique — Pays : France — Rôle : PI
Acronyme de l'entité : CNRS
Type d'entité : Recherche
Financement ERC de l'entité : 1415974.0 €

One of the most powerful ideas of the past quarter century is that our personal and social identities and their various components (gender, age, class etc.) are not natural properties, but are socially constructed through the combination of our actions and others' interpretations of them. Research in sociolinguistics has shown that language is critical to this process, and our interlocutors take into account not only what we say but also how we say it. For example, studies have shown that speakers using colloquial expressions (like pronouncing the word 'drinking' as drinkin') are perceived to be friendlier than speakers saying the same thing using more formal expressions (i.e. saying drinking). On the other hand, the latter are often perceived to be more competent than those using colloquial language. Although identity construction through language is a fundamental notion in the humanities and social sciences, we do not yet have a precise characterization of the cognitive processes involved. As a result, these influential ideas have remained isolated from work in cognitive science, computer science and artificial intelligence. The goal of SMIC is therefore to construct a mathematically explicit, computationally implemented theory of the identity construction process based on the hypothesis that identity construction is very similar to other kinds of linguistic communication, i.e. hearing drinkin' and thinking that the speaker is friendly is the same basic cognitive process as hearing drinkin' and thinking about imbibing liquid. Modeling linguistic communication is a central concern of formal pragmatics, and recent developments in this field have created exciting new experimental, mathematical and computational tools for studying linguistic meaning in context. SMIC aims to take advantage of these developments to build the model, and, in doing so, unite diverse lines of research across the social, cognitive and information sciences.

Mots-clés : social meaning,identity construction,game theory,pragmatics,semantics,sociolinguistics,gender,dialectology,computational modeling,psycholinguistics,fieldwork,ideological structure
Projet ERC : MenWomenCare (Horizon 2020, appel 2014, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Leeds — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1079426.0 €

One of the most profound and long-lasting effects of the war efforts of all major combatant nations during the First World War was the high number of casualties caused by modern industrial warfare. Examining the case of Britain, this project asks what formal and informal structures developed in the interwar years to provide medical and social care to the unprecedented number of war disabled. It further explores how these different forms of care both were shaped by gendered understandings of care-giving and utilized gender to mobilize public and private support for disabled ex-servicemen. While there have been a number of studies of charitable organizations established for the care of disabled ex-servicemen, and of the relationships between the State, the soldier and his family in this era, this is the first study to examine the role of these formal institutions alongside and in relation to the informal social and medical care provided by the family in this period. Through its examination of issues of social, political and domestic responsibility for the care of disabled ex-servicemen, issues which continue to have relevance in light of the survival of service personnel from conflicts such as Iraq and Afghanistan who have suffered massive injuries and multiple amputations, the project seeks not only to engage with historical discussions of the development of medical practice in the first half of the twentieth century but also, through engagement with current policy makers working with and for disabled service personnel, to make a significant intervention into contemporary social policy relating to the provision of medical and social care. By utilizing the methodological prism of gender studies, this project also explores the ways in which medical and social care were gendered to interrogate social and cultural understandings of care-giving in the first half of the 20th century and thereby gain greater insight into the relationships between men, women and care.

Mots-clés : history of masculinity,history of disability,first world war,history of medicine,history of the family,history of welfare,personal narrative,care giving,social care,social policy
Projet ERC : MFreePEC (Horizon 2020, appel 2019, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Synthetic Chemistry and Materials
Entité participante : Ben-Gurion University of the Negev — Pays : Israël — Rôle : PI
Acronyme de l'entité : BGU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1495850.0 €

One of the most promising future sources of alternative energy involves photoelectrochemical cells (PECs) that can convert sunlight and water directly to clean hydrogen fuel. Up to now, the PEC field has been dominated mostly by metal-based materials and despite the progress in this field, semiconductors that fulfil all the stringent requirements as PEC semiconductors do not exist today and novel materials are still much sought after. Thus, the development of suitable semiconductor materials will be a game changer, allowing PECs to fulfil their role in the energy-devices landscape. The aim of this project is to introduce a new class of metal-free materials that are particularly suitable as semiconductors in PECs through the development of new strategies for the controlled synthesis and growth of metal-free materials on various substrates, ranging from carbon nitride to nitrogen-doped carbon and new carbon-nitrogen-phosphorus/boron/sulfur materials (referred as CNXs, X = P, B or S). Central to this goal is the understanding of the growth mechanism of CNX layers from the molecular level, which will in turn permit the rational design of synthesis and deposition methods. More specifically, we will (i) develop effective deposition pathways of CNXs on substrates with controlled properties, (ii) understand the factors that determine the CNX layer properties and, from this, (iii) control CNXs properties such as band gap, exciton lifetime, crystallinity, porosity, and electronic structure, with the aim of improving their photoelectrochemical activity through rational design of the synthetic parameters. This highly interdisciplinary proposal combines materials science, photoelectrochemistry and supramolecular chemistry. It will open up new opportunities in these fields, in particular in the synthesis and deposition of metal-free materials, and it will significantly accelerate the integration of lightweight materials into energy–conversion and other devices.

Mots-clés : light elements materials,carbon nitride,carbon nitride heteroatoms,photoelectrochemical cells,2d materials,self assembly,carbon nitride films
Projet ERC : SELFORGANICELL (Horizon 2020, appel 2015, Starting grants)
Domaine scientifique : Life Science
Panel : Molecules of Life: Biological Mechanisms, Structures and Functions
Entité participante : Institute of Science and Technology Austria — Pays : Autriche — Rôle : PI
Acronyme de l'entité : ISTA
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1496686.99 €

One of the most remarkable features of biological systems is their ability to self-organize in space and time. Even a relatively simple cell like the bacterium Escherichia coli has a precisely regulated cellular anatomy, which emerges from dynamic interactions between proteins and the cell membrane. Self-organization allows the cell to perform extremely challenging tasks. For example, for cell division, more than ten different proteins assemble into a complex, yet highly dynamic machine, which controls the invagination of the cell while constantly remodeling itself. Although the individual components involved have been largely identified, how they act together to accomplish this challenge is not understood. It has become clear that sophisticated biochemical networks give rise to intracellular organization, but we have yet to uncover the underlying mechanistic principles. In this research proposal, I aim to develop a detailed mechanistic understanding of the self-organizing, emergent properties of the cell. To this end, my research group will develop novel in vitro reconstitution experiments combined with high-resolution fluorescence microscopy and theoretical modeling. Following this “bottom-up” approach, we will quantitatively analyze collective protein dynamics and emergent mechanochemical properties of the bacterial cell division machinery. I aim to answer the following fundamental questions: 1) What is the biochemical network giving rise to the dynamic assembly of the divisome? 2) How do the components of the divisome interact to generate force? 3) How do peptidoglycan synthases build the cell wall? By comparing protein dynamics in vitro with those measured in vivo, we will provide a link between molecular properties and the processes found in the living cell. This project will not only improve our understanding of the bacterial cell, but also open new research avenues for eukaryotic cell biology, synthetic biology and biophysics.

Mots-clés : self organization,synthetic biology,in vitro reconsitution,bacterial cell biology
Projet ERC : BECAME (Horizon 2020, appel 2019, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Synthetic Chemistry and Materials
Entité participante : University of Santiago de Compostela — Pays : Espagne — Rôle : PI
Acronyme de l'entité : USC
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1999679.0 €

One of the remaining primary challenges in modern chemistry is the development of clean, energy- and cost-efficient catalytic processes that can allow to convert simple and abundant chemical feedstocks into high value-added products. Given the vast reserves of methane from natural gas, available worldwide, the direct use of the simplest alkane as source of fuels and chemicals could have a great impact in our society. However, methane´s low intrinsic reactivity has rendered its use extremely difficult for purposes beyond aerobic combustion and the production of syngas. Despite some recent advances in the field, a general strategy for a diverse and versatile use of methane is elusive. The overall aim of this proposal is the development of a new paradigm in catalysis which can provide new catalytic processes that allow direct methane functionalization by using it as a methylating reagent in a variety of C-C bond forming reactions. The approach described in this proposal is based on a cooperative interaction between two transition metal complexes in which an early transition metal is responsible for the methane C-H activation and a late transition metal is the actual catalyst of the methylation process. The link between these two processes is a transmetalation step and will be used to transfer the mechanism of typical cross-coupling reactions to the field of methane functionalization. New pathways for the direct use of methane in reactions such as allylic alkylation, conjugate addition, cross-coupling, C-H methylation and alkene hydromethylation will be developed based on this novel bimetallic catalytic strategy. It is envisioned that the proposed research will lead to a new concept at the interface of catalytic cross coupling reactions and C-H activation. It will contribute to the fundamental understanding of these two reactions and will provide the basis for a new technology for energy efficient and environmentally friendly, thus sustainable, methane conversion.

Mots-clés : organometallic chemistry
Projet ERC : EPP (Horizon 2020, appel 2016, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Individuals, Markets and Organisations
Entité participante : University of London — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : U. London
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1291064.0 €

One of the ultimate goals of economics is to inform a policy that improves welfare. Despite that the vast amount of empirical works in economics aims to achieve this goal, the current state of the art in econometrics is silent about concrete recommendation for how to estimate the welfare maximizing policy. This project addresses statistically optimal and practically useful ways to learn the welfare-maximizing policy from data by developing novel econometric frameworks, sampling design, and estimation approaches that can be applied to a wide range of policy design problems in reality. Development of econometric methods for optimal empirical policy design proceeds by answering the following open questions. First, given a sampling process, how do we define optimal estimation for the welfare-maximizing policy? Second, what estimation method achieves this statistical optimality? Third, how do we solve policy decision problem when the sampling process only set-identifies the social welfare criterion? Fourth, how can we integrate the sampling step and estimation step to develop a package of optimal sampling and optimal estimation procedures? I divide the project into the following four parts. Each part is motivated by important empirical applications and has methodological challenges related to these four questions. 1) Estimation of treatment assignment policy 2) Estimation of optimal policy in other public policy applications 3) Policy design with set-identified social welfare 4) Sampling design for empirical policy design

Mots-clés : microeconometrics,program evaluation,decision theory,partial identification,machine learning