Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : INSITE (Horizon 2020, appel 2017, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : KU Leuven — Pays : Belgique — Rôle : Partner
Acronyme de l'entité : KUL
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 726375.0 €

Tissue Engineering (TE) refers to the branch of medicine that aims to replace or regenerate functional tissue or organs using man-made living implants. As the field is moving towards more complex TE constructs with sophisticated functionalities, there is a lack of dedicated in vitro devices that allow testing the response of the complex construct as a whole, prior to implantation. Additionally, the knowledge accumulated from mechanistic and empirical in vitro and in vivo studies is often underused in the development of novel constructs due to a lack of integration of all the data in a single, in silico, platform. The INSITE project aims to address both challenges by developing a new mesofluidics set-up for in vitro testing of TE constructs and by developing dedicated multiscale and multiphysics models that aggregate the available data and use these to design complex constructs and proper mesofluidics settings for in vitro testing. The combination of these in silico and in vitro approaches will lead to an integrated knowledge-rich mesofluidics system that provides an in vivo-like time-varying in vitro environment. The system will emulate the in vivo environment present at the (early) stages of bone regeneration including the vascularization process and the innate immune response. A proof of concept will be delivered for complex TE constructs for large bone defects and infected fractures. To realize this project, the applicant can draw on her well-published track record and extensive network in the fields of in silico medicine and skeletal TE. If successful, INSITE will generate a shift from in vivo to in vitro work and hence a transformation of the classical R&D pipeline. Using this system will allow for a maximum of relevant in vitro research prior to the in vivo phase, which is highly needed in academia and industry with the increasing ethical (3R), financial and regulatory constraints.

Mots-clés : in silico modeling,computational modeling,tissue engineering,mesofluidics,in vitro,bioprocess engineering,systems biology,bone regeneration
Projet ERC : ESTIA (Horizon 2020, appel 2015, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Mathematics
Entité participante : University of Bristol — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1873483.0 €

Title: Exponential Sums, Translation Invariance, and Applications. Short Summary: Exponential sums are fundamental throughout (analytic) number theory, and are key to the robustness of applications in theoretical computer science, cryptography, and so on. They are the primary tool for testing equidistribution (apparent “randomness”) of number theoretic sequences. For a century, bounds for such sums of degree 3 or more have fallen far short of those conjectured to hold. The landscape for exponential sums changed decisively in late 2010, when the proposer devised the “efficient congruencing” method. As a result, mean value estimates associated with translation invariant systems are now within a whisker of the main conjectures. Very significant progress has resulted in such Diophantine applications as Waring's problem, the validity of the Hasse principle for systems of diagonal equations, and equidistribution of polynomial sequences mod 1. It is little understood in the wider community that efficient congruencing offers a fundamentally new approach to estimating moments of Fourier coefficients of wide generality, with hitherto inaccessible applications. We propose: (i) to generalise efficient congruencing to approximately translation invariant systems, and explore consequent applications to Diophantine problems such as Waring's problem, restriction problems from discrete Fourier analysis, and bounds for the Riemann zeta function within the critical strip; (ii) to extend the method to the multidimensional setting relevant to the investigation of local-global principles for spaces of rational morphisms from rational curves to diagonal hypersurfaces; (iii) to explore the application of efficient congruencing over function fields where the ground field is a finite field, in particular as a vehicle for establishing estimates of use in randomness extractors; (iv) to investigate the potential use of higher degree translation invariance in generalising Gowers norms.
Projet ERC : MUSICOL (Horizon 2020, appel 2018, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : Fondation de l’ENS-PSL — Pays : France — Rôle : Partner
Acronyme de l'entité : FENS
Type d'entité : Autres
Financement ERC de l'entité : 341110.0 €

To better understand cultural relations in today’s multi-ethnic, multicultural societies, we need to revisit the legacy of modern empires. This project delves into the musical dimension of the French empire and what differences were negotiated through aurality, long-neglected by historians. Focusing on musical life and media from Dakar and Rabat to Saigon, 1900-1962, it studies how music was practiced, heard, and understood in a variety of colonial contexts. Crucially important is the need to investigate the tastes, practices, and interactions of Europeans and natives, usually studied in isolation. Such scope requires an entirely new methodological paradigm: relational, comparative, and integrative-synthetic. Traversing disciplinary boundaries separating musicology from history, media studies, and ethnomusicology, the project has four objectives: (1) To musicalize history, it probes what musical fields of production contribute to current debates on the nature of empire and colonial identities. (2) To historicize aural media, it examines live and recorded music on radio as windows on the dynamic nature of colonial coexistence. (3) To globalize music history, it brings new coherence with its focus on a single empire and without imposing postcolonial models of domination/resistance. (4) To creolize research, it integrates indigenous research and promotes dialogue with collaborators from the former empire. Foundations laid by the PI’s prior research in colonial archives, availability of sources, each team member’s expertise and focus on one field, their shared method, and common purpose insure its feasibility. This pioneering study of the modern French empire through music will generate new insights into its mechanisms and constituencies, taking colonial, media, and music history in unprecedented directions. Only in understanding the aurality of colonialism--what helped their imperialism take hold and last--can Europeans grasp its full nature, meaning, and legacy.

Mots-clés : colonial radio history,colonial governance,urban spaces,french empire,concerts,musical networks
Projet ERC : CICERO (Horizon 2020, appel 2016, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Physical and analytical chemical sciences
Entité participante : Board of the Swiss Federal Institutes of Technology — Pays : Suisse — Rôle : PI
Acronyme de l'entité : ETH Zurich
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2130088.0 €

To date no experiment has investigated ion-molecule reactions at temperatures significantly below about 20 K, for two reasons: (i) Cooling the translational and internal degrees of freedom of ions and molecules is extremely challenging. (ii) Even very weak stray electric fields accelerate the ions. A potential difference of only 1 mV across the reaction volume imparts a kinetic energy of 1 meV to ions, which corresponds to a temperature of about 12 K. Quantum mechanical effects arising from the translational and the frozen or hindered rotational motion of the reactants in the intermolecular potential are only expected to be significant below 20 K and have therefore not been observed yet in ion-molecule reactions, even for reactions involving the lightest ions and molecules. This proposal aims at developing a new experimental method to study ion-molecule reactions at temperatures down to 100 mK and to study ion-molecule reactions involving light species, with particular emphasis placed on the observation and quantification of quantum effects in low-temperature ion-molecule chemistry. To reach this goal, we will study the ion-molecule reactions within the orbit of a highly excited Rydberg electron, which will shield the reaction from stray fields without affecting its outcome. To reach very low collision energies, we will use a merged-beam approach relying on a surface-electrode Rydberg-Stark deflector. In the preparatory phase of this proposal, we have carried out a proof-of-principle measurement of the H2+ + H2 -> H3+ + H reaction below 1 K using a simplified version of the "ideal" instrument and demonstrated the feasibility of our method. We now plan to exploit the full potential of our new approach and study important ion-molecule reactions in a temperature range thought until now to be experimentally inaccessible.

Mots-clés : ion molecule reactions,cold chemistry,rydberg molecules
Projet ERC : CLIFF (Horizon 2020, appel 2020, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : University of Amsterdam — Pays : Pays-Bas — Rôle : PI
Acronyme de l'entité : UvA
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2499192.0 €

To halt climate change, the 2015 Paris Agreement implicitly requires leaving fossil fuels (FF) underground (LFFU) and coherent financial flows. This implies stranding huge amounts of FF resources and assets (worth $16-300 trillion), affecting big investors: FF firms, shareholders (pension funds/philanthropies), debt financers (aid agencies/development banks) and governments. Research is scarce on big investors, the implications for developing countries with FF resources, and how LFFU can be equitably mobilized. Hence, CLIFF addresses the question: What is the role of big investors in leaving fossil fuels underground (LFFU), what are the North-South implications of LFFU and what measures can be taken by whom to equitably allocate and accelerate shareholder and stakeholder responsibility in energy transformation for inclusive development? LFFU has high stakes, disputed values, and urgency, so CLIFF combines institutional analysis and a theory of change for inclusive development (ICID) using a transdisciplinary, comparative case study approach. It has 4 substantive work packages: (a) a research protocol; (b) case studies on FF firms; pension funds; philanthropic foundations; aid agencies/development banks; developing countries with new FFs; (c) a geo-political analysis, and (d) an integrative analysis. CLIFF innovatively examines big investors and countries with new FF discoveries and growing vested interests in opposing climate policy implementation; and agents of change who address these vested interests (theory of change). CLIFF develops an innovative theoretical model (ICID) to analyse these actors and the changing North-South aspects, a CLIFF Interactive Atlas, and a Stranded Asset Index, co-creates equitable policy instruments; and assesses strategies of agents of change to make such climate policy instruments politically feasible and effective. Rather than ‘Building Back Better’ from the COVID-19 pandemic, CLIFF strives for Catalysing Climate-resilient Change.

Mots-clés : inclusive development,theory of change,stranded assets,stranded resources,institutional analysis,financial actors,fossil fuel,north south,pension funds,philanthropic foundations,export credit,development banks
Projet ERC : EnTER (Horizon 2020, appel 2019, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : Delft University of Technology — Pays : Pays-Bas — Rôle : PI
Acronyme de l'entité : TU Delft
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1500000.0 €

To meet the growing demand for green energy carriers and clean water for the next decades, we can use the increasing supply of harvested solar and wind energy to synthesize fuels (hydrogen, syngas, ammonia, etc.) and clean water via electrochemical methods. Electrochemical methods have the advantage of single-step, energy-efficient and low-temperature conversion of chemicals. However, despite developments in electrocatalysts and system design in the past decade, none of the electrochemical methods has grown to a market-leading technology in the energy or water sector because of limitations in process intensification. A boost in electrical current density, without sacrificing energy efficiency, is required to allow large-scale deployment. This process intensification needs breaking three limitations in mass transport, at three different scales: 1) the diffusion boundary layer (microscale), 2) gas bubble interference (mm-scale) and 3) concentration gradients in the flow compartments bulk. This ERC project will use a multiscale approach to address these three mass transport limitations, and has the objective to understand and enhance mass transport using novel concepts. Diffusion limitations will be addressed via studying suspension electrodes, gas bubbles will be controlled while synergistically disturbing the diffusion boundary layer via pressure swing control, and reactor engineering concepts that are new to the field of electrochemistry are used to mitigate macro-scale concentration gradients. Water electrolysis, CO2 electrolysis and electrodialysis will be used as tool to evaluate these strategies, using fluorescence lifetime imaging (FLIM) and micro particle image velocimetry (μPIV) to observe the local environment at microscale within large-scale systems. This multiscale approach with in-situ measurements of local flow and concentrations will target the fundamental understanding and control of mass transport limitations for universal electrochemical conversion.
Projet ERC : STRATIFY (Horizon 2020, appel 2015, Advanced grants)
Domaine scientifique : Life Science
Panel : Prevention, Diagnosis and Treatment of Human Diseases
Entité participante : University of London — Pays : Royaume-Uni — Rôle : Partner
Acronyme de l'entité : U. London
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1646900.33 €

To reduce the burden of mental disorders it is a formidable aim to identify widely applicable disease markers based on neural processes, which predict psychopathology and allow for targeted interventions. We will generate a neurobehavioural framework for stratification of psychopathology by characterising links between network properties of brain function and structure and reinforcement–related behaviours, which are fundamental components of some of the most prevalent mental disorders, major depression, alcohol use disorder and ADHD. We will assess if network configurations define subtypes within and if they correspond to comorbidity across these diagnoses. We will identify discriminative data modalities and characterize predictors of future psychopathology. To identify specific neurobehavioural clusters we will carry out precision phenotyping of 900 patients with major depression, ADHD and alcohol use disorders and 300 controls, which we will investigate with innovative deep machine learning methods derived from artifical intelligence research. Development of these methods will optimize exploitation of a wide range of assessment modalities, including functional and structural neuroimaging, cognitive, emotional as well as environmental measures. The neurobehavioural clusters resulting from this analysis will be validated in a longitudinal population-based imaging genomics cohort, the IMAGEN sample of over 2000 participants spanning the period from adolescence to adulthood and integrated with information generated from genomic and imaging-genomic meta-analyses of >300.000 individuals. By targeting specific neural processes the resulting stratification markers will serve as paradigmatic examples for a diagnostic classification, which is based upon quantifiable neurobiological measures, thus enabling targetted early intervention, identification of novel pharmaceutical targets and the establishment of neurobehaviourally informed endpoints for clinical trials.
Projet ERC : Bi3BoostFlowBat (Horizon 2020, appel 2020, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : University of Turku — Pays : Finlande — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499880.0 €

To satisfy our growing energy demand while reducing reliance on fossil fuels, a switch to renewable energy sources is vital. The intermittent nature of the latter means innovations in energy storage technology is a key grand challenge. Cost and sustainability issues currently limit the widespread use of electrochemical energy storage technologies, such as lithium ion and redox flow batteries. As the scale for energy storage is simply enormous, the only option is to look for abundant materials. However, compounds that fulfil the extensive requirements entailed at low cost has yet to be reported. While it is possible that the holy grail of energy storage will be found, for example by advanced computational tools and machine learning to design “perfect” abundant molecules, a more flexible, innovative solution to sustainable and cost-effective large-scale energy storage is required. Bi3BoostFlowBat will develop game changing strategies to widen the choice of compounds utilizable for batteries to simultaneously satisfy the requirements for low cost, optimal redox potentials, high solubility and stability in all conditions. The aim of this project is to develop cost-efficient batteries by using solid boosters and by eliminating cross over. Two approaches will be pursued for cross-over elimination 1) bio-inspired polymer batteries, where cross-over of solubilized polymers is prevented by size-exclusion membranes and 2) biphasic emulsion flow batteries, where redox species are transferred to oil phase droplets upon charge. Third research direction focuses on systems to maintain a pH gradient, to allow operation of differential pH systems to improve the cell voltages. Limits of different approaches will be explored by taking an electrochemical engineering approach to model the performance of different systems and by validating the models experimentally. This work will chart the route towards the future third generation battery technologies for the large-scale energy storage.

Mots-clés : flow batteries,redox active solids,energy storage,liquid liquid electrochemistry,bipolar membranes
Projet ERC : microCrysFact (Horizon 2020, appel 2015, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : Board of the Swiss Federal Institutes of Technology — Pays : Suisse — Rôle : Partner
Acronyme de l'entité : ETH Zurich
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1100981.0 €

To study and understand the aggregation, nucleation, and/or self-assembly processes of crystalline matter is of crucial importance for research and applications in many disciplines. For example, understanding the formation of crystalline amyloid fibres could lead to advances in the treatment and prevention of both Alzheimer’s and Parkinson’s diseases, whereas controlling the process of crystal formation can play a significant role in obtaining chemicals and materials that are important for industry as well as society as a whole (e.g., drugs, superconductors, polarizers and/or frequency modulators). Despite the impressive progress made in molecular engineering during the last few decades, the quest for a general tool-box technology to study, control and monitor crystallisation processes as well as to isolate metastable states (dynamic capture) is still incomplete. That is because crystalline assemblies are frequently investigated in their equilibrium form, driving the system to its minimum energy state. This methodology limits the emergence of new chemicals and crystals with advanced functionalities, and thus hampers advances in the field of materials engineering. µ-CrysFact will develop tool-box technologies where diffusion-limited and kinetically controlled environments will be achieved during crystallisation and where the isolation of non-equilibrium species will be facilitated by pushing crystallisation processes out of equilibrium. In addition, µ-CrysFact’s technologies will be used to localise, integrate and chemically treat crystals with the aim of honing their functionality. This unprecedented approach has the potential to lead to the discovery of new materials with advanced functions and unique properties, thus opening new horizons in materials engineering research.

Mots-clés : technology,crystallisation processes,molecular engineering,metastable states,thermodynamic state,kinetically controlled environments,localisation,integration,and functional matter
Projet ERC : microCrysFact (Horizon 2020, appel 2015, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : Board of the Swiss Federal Institutes of Technology — Pays : Suisse — Rôle : Partner
Acronyme de l'entité : ETH Zurich
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

To study and understand the aggregation, nucleation, and/or self-assembly processes of crystalline matter is of crucial importance for research and applications in many disciplines. For example, understanding the formation of crystalline amyloid fibres could lead to advances in the treatment and prevention of both Alzheimer’s and Parkinson’s diseases, whereas controlling the process of crystal formation can play a significant role in obtaining chemicals and materials that are important for industry as well as society as a whole (e.g., drugs, superconductors, polarizers and/or frequency modulators). Despite the impressive progress made in molecular engineering during the last few decades, the quest for a general tool-box technology to study, control and monitor crystallisation processes as well as to isolate metastable states (dynamic capture) is still incomplete. That is because crystalline assemblies are frequently investigated in their equilibrium form, driving the system to its minimum energy state. This methodology limits the emergence of new chemicals and crystals with advanced functionalities, and thus hampers advances in the field of materials engineering. µ-CrysFact will develop tool-box technologies where diffusion-limited and kinetically controlled environments will be achieved during crystallisation and where the isolation of non-equilibrium species will be facilitated by pushing crystallisation processes out of equilibrium. In addition, µ-CrysFact’s technologies will be used to localise, integrate and chemically treat crystals with the aim of honing their functionality. This unprecedented approach has the potential to lead to the discovery of new materials with advanced functions and unique properties, thus opening new horizons in materials engineering research.

Mots-clés : technology,crystallisation processes,molecular engineering,metastable states,thermodynamic state,kinetically controlled environments,localisation,integration,and functional matter