Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : CTC-MAL (Horizon 2020, appel 2017, Proof of concept grants)
Entité participante : University of Copenhagen — Pays : Danemark — Rôle : PI
Acronyme de l'entité : UCPH
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 149375.0 €

In 2013 I was awarded an ERC consolidator grant to pursue a novel cancer targeting concept using a recombinant malaria protein. As an ERC grantee I verified the malaria protein (rVAR2) binds to this distinct cancer expressed molecule (CSA) in hundreds of cancer cell lines and thousands of tissue biopsies. Our research demonstrate a pivotal role of CSA in cancer cell migration and thus in the formation of metastasis. Circulating tumor cells (CTCs) are cancer cells escaping the primary tumor with the capacity to settle and form a metastasis in distant organs. Isolation of CTC is thus a very attractive non-invasive measure of the stage of a given cancer and provides the opportunity to do direct phenotypic analyses. However CTCs are in most cases very rare (10 cells pr 1ml blood) and does not uniformly distinguish themselves from normal blood cells. Our preliminary data show that rVAR2 very effectively can be used to isolate CTCs from diverse types of cancer with unprecedented specificity and sensitivity. Such a tool could have wide impact for cancer patients because it could sharpen diagnosis, increase prognostic ability, monitor drug efficacy and facilitate molecular characterization of individual cancers with implications for personalized medicine and basic cancer research. The aim of the ERC PoC project is to A) prepare for establishment of a separate company with a strategic product plan and B) further develop and validate the methodology enabling diagnosis, prognosis and guide treatment.

Mots-clés : cancer,circulating tumor cells,liquid diagnostics,diagnostic
Projet ERC : CONNEC (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of London — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : U. London
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1333336.0 €

In 380 CE, the Emperor Theodosius (d. 395) ordered all Roman subjects to follow Catholic Christianity and limited imperial patronage to the Catholic Church. Theodosius was the last ruler to reign over a united empire. At his death the realm was divided into two halves, and by the end of Gregory the Great’s papacy (d. 604), a mosaic of independent kingdoms had replaced the western part of the empire. Yet despite the political division, during this period western clerics built a supra-regional ecclesiastical structure with substantial levels of hierarchy and cohesion. Up to the 1950s historians have largely conceived of these ecclesiastical institutions as organizations with widely accepted power. More recent scholarship, however, has revealed the social origin and fallibility of clerical authority. Nonetheless, this move away from the study of institutions has left unanswered the fundamental questions of how a ‘universal’ church was built at a time of political fragmentation, and how the transition from informal mutual aid to more formal hierarchical structures of law- and policy-making came about. With innovative methods of social inquiry we can offer new answers to these historiographical questions. Our project (CONNEC) will use social network analysis and new institutional theory to trace four processes: how clerical networks adapted to the new secular contexts, how these interactions shaped the development of ecclesiastical law, how clerics constructed and disseminated discourses that supported different structures of the church, and how networks fostered compliance and a sense of accountability among clerics. CONNEC’s use of state-of-the-art methods will be enhanced by the implementation of cutting-edge digital technologies, adapting network analysis software for late antique sources. By bringing together digital tools with qualitative textual analysis, CONNEC will provide a more nuanced understanding of a key process of world history.

Mots-clés : history of late antiquity,history of the christian church
Projet ERC : DIAMONDCOR (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Life Science
Panel : Prevention, Diagnosis and Treatment of Human Diseases
Entité participante : Leibniz Association — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : LG
Type d'entité : Recherche
Financement ERC de l'entité : 1233329.96 €

In Europe, 59 million patients suffer from diabetes mellitus with health costs of 142 billion Euros per year. As one of the most challenging consequences, diabetes inflicts cardiovascular disease leading to cardiomyopathy and cardiac death. A global, current aim lies in preventing cardiac complications in patients with diabetes mellitus. In pathogenesis of diabetic cardiomyopathy, the role of microvascular processes remains largely elusive; my proposal aims at solving this key question – an impossible mission so far. As attractive therapeutic concept and overall objective, the present proposal aims at exploiting microvascular mechanisms for preventing and treating diabetic cardiomyopathy. I will study a novel, unique transgenic pig model of diabetes mellitus combined with advanced, patient compatible molecular imaging. We pioneered distinct genetic manipulations in pigs, including adeno-associated viral vectors (AAV) for microvessel stabilization as well as AAV-based CrispR/Cas9 transduction for in vivo genome editing. Using this cutting edge technology, I could decipher an important role for microvascular capillary rarefaction in the development of diabetic cardiomyopathy in my previous work. In the present proposal, I aim at determining 1. novel, microvascular-focused therapeutic targets for diabetic cardiomyopathy 2. the effect of reduced microvascular damage on myocardial function in diabetes, both in the absence and presence of ischemia. My approach will implement targeting microvessels as new paradigm for treating diabetic cardiomyopathy. I will identify novel therapeutic targets for tailored drug development by industry and academia. My planned work will improve the success rate of clinical trials for the benefit of patients suffering diabetic cardiomyopathy and putatively other cardiac diseases.
Projet ERC : SENSOCOM (Horizon 2020, appel 2014, Consolidator grants)
Domaine scientifique : Life Science
Panel : Neuroscience and Disorders of the Nervous System
Entité participante : Max Planck Society — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : MPG
Type d'entité : Recherche
Financement ERC de l'entité : 943610.15 €

In Europe, approximately one hundred million people are impaired in their communication abilities. These include people with autism spectrum disorders (ca. 3 million) and individuals with dyslexia (ca. 50 million). Current neuroscience research typically associates cognitive functions including communication abilities with the cerebral cortex. By and large, this approach ignores the complex subcortical processing machinery before sensory signals reach the cortex. However, recent pioneering studies imply that dysfunction in tiny subcortical sensory structures can cause selective deficits in our ability to understand others. My goal is to (i) investigate the role of subcortical sensory structures in analysing communication signals and (ii) specify how dysfunction in subcortical-cortical interaction can cause human communication disorders. To do this we will combine very recently developed ultra-high-resolution neuroimaging with a cutting-edge multimodal approach including neurostimulation, and computational neuroimaging. The project will relate sensory subcortical responses to concrete communication behaviour, as observed in healthy individuals and individuals with communication disorders. I expect two key results: First, we will uncover the principles of how subcortical sensory structures operate for dynamic auditory and visual communication signals; this will lead to a novel model of subcortical-cortical interactions that can explain key functions in human communication. Second, the results will resolve long-standing puzzles about the nature of two of the most common hereditary communication deficits (developmental dyslexia and autism spectrum disorders). Immediate consequences of this proposal will include a translational project aimed at improving communication functions with behavioural interventions. Together, the findings may revolutionise our understanding of how sensory subcortical structures shape one of our most important cognitive functions—communication.

Mots-clés : dyslexia,sensory thalamus,predictive coding,top down modulation,cortico thalamic interaction
Projet ERC : LeukaemiaTargeted (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Life Science
Panel : Prevention, Diagnosis and Treatment of Human Diseases
Entité participante : Ludwig-Maximilians-Universität München — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : LMU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 270308.0 €

In Europe, around two million individuals die from cancer each year. Cancer is a genetic disease and each patient's tumour contains several genetic lesions which are identified by next generation sequencing (NGS) and influence patient's outcome. A global current challenge lies in translating NGS data into benefit of cancer patients. As attractive novel therapeutic concept, precision medicine addresses genetic lesions using targeted therapies. A large number of targeted drugs and compounds exist and are currently developed such as kinase inhibitors; unfortunately, numerous clinical trials on targeted therapies failed. In order to better exploit NGS data, it is important to discriminate between genetic lesions that are required and maintain patients' tumours in vivo and others that do not – an impossible mission so far. My proposal aims at solving this key question. Using acute leukaemia as model tumour disease, we propagate primary tumour cells from patients in immuno-deficient mice. We recently pioneered a worldwide unique technique which allows the distinct genetic manipulation of individual patients' tumour cells while they grow in vivo. We will molecularly target tumour-specific genetic lesions one by one; if tumour load is reduced, the lesion fulfils an essential function; essential lesions represent attractive therapeutic targets. Using our cutting edge technology, we will identify genetic lesions with essential, tumour-relevant function (i) in established tumour disease and (ii) in the clinically challenging situations of minimal residual disease and relapse. Our approach implements a new paradigm for target selection in oncology. Our work introduces molecular target validation as important step into the value chain of precision medicine which will tailor drug development by industry and academia. Our approach will improve patient care and the success rate of clinical trials for the benefit of patients suffering acute leukaemia and putatively other cancers.

Mots-clés : target validation,in vivo function of genomic mutations,preclinical in vivo models,acute leukaemia,primary tumour cells of individual patients,patient derived xenografts,genetic engineering
Projet ERC : DEMOSERIES (Horizon 2020, appel 2018, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : Université Paris 1 - Panthéon Sorbonne — Pays : France — Rôle : PI
Acronyme de l'entité : Paris 1
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2216375.0 €

In France, the UK, Germany, the US, and Israel, a growing number of films and television series are set ‘behind the scenes’ of democratic regimes faced with terrorist threats. These works reveal a moral state of the world. They may be analysed as ‘mirrors’ of society, or as ideological tools. But they can also be understood as new resources for the education, creativity, and perfectibility of their audiences; as the emergence of a form of ‘soft power’ that can serve as a resource for public policies and democratic conversation. Because of their format (weekly/seasonal regularity, home viewing) and the participatory qualities of the Internet (tweeting, sharing, liking, chat forums), series allow for a new form of education by expressing complex issues through narrative and characters. As a result, TV series are increasingly recognised in current research. However, their aesthetic potential for visualising ethical issues and their capacity at enabling a democratic empowerment of viewers has not yet been analysed ; nor their power for confronting cultural and social upheavals underway, and developing a collective inquiry into democratic values and human security. DEMOSERIES brings together a team of scholars of moral philosophy, film studies, digital media and cultural data, sociology, law and political science, to explore a corpus of TV ‘security series’ from conception to reception. Doing so requires a particularist ethics based on attention to multi-faceted situations, paired with qualitative methods (interviews with security experts, showrunners, viewers; analyses of images, tropes, words; ethnography of reception) and quantitative methods (tweets and web analytics). By elucidating how these series are conceived by their creators and audiences, DEMOSERIES thus aims to understand if and how they might play a crucial role in building the awareness necessary for the safety of individuals and societies, and in creating shared and shareable values in the EU and beyond.

Mots-clés : television,ethics,political philosophy,film,security,democracy,education,violence,realism
Projet ERC : OPenPal (Horizon 2020, appel 2016, Proof of concept grants)
Entité participante : Scuola Normale Superiore — Pays : Italie — Rôle : Partner
Acronyme de l'entité : SNS
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

In Humanities, written correspondence is a fundamental object of study. The current IT revolution provides means for reassembling and disseminating this precious literary heritage for the first time, while at the same time fostering new forms of scholarly cooperation. As letters create links between people, the value of documents and data increases when different corpora of written correspondences are interconnected and linked. Despite the strong need for common standards and common tools to exploit these connections and to reconstruct the discourse of the Republic of Letters, there is still no simple framework in the current panorama for publishing digitized correspondence corpora. The OPenPal project, led by Prof. Ghelardi, aims to develop a prototype system to manage, publish, export and visualise corpora of various types of correspondence in innovative ways: the idea is therefore to move from the EU-funded project EUROCORR (storing and displaying the critical edition of the correspondence to Jacob Burckhardt (1842-1897) – http://fe.burckhardtsource.org/ –) and to generalise both workflow and data model to new correspondence corpora, by refactoring and redesigning the architecture of Burckhardtsource. The expected outcomes of the OPenPal project will be to produce a prototype to publish digital correspondences (i.e. manuscripts, texts and data) and a toolkit to manage these special editions. OPenPal prototype will enable users to browse texts and data through guided paths, infographic visualisations, and will make it possible to browse a unique space of linked knowledge and trigger social mechanisms for discussion and debate on letters, thus opening from a niche of scholarly content to a wider audience. As a whole, this process will identify a sustainable business model for the new tool, based on linked data technologies in correspondence digital editions.

Mots-clés : correspondence corpora,unique browse space,common standards,open education resources,eurocorr data model,infographic visualisations,multilingual interface,new users categories
Projet ERC : OPenPal (Horizon 2020, appel 2016, Proof of concept grants)
Entité participante : Università Iuav di Venezia — Pays : Italie — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 150000.0 €

In Humanities, written correspondence is a fundamental object of study. The current IT revolution provides means for reassembling and disseminating this precious literary heritage for the first time, while at the same time fostering new forms of scholarly cooperation. As letters create links between people, the value of documents and data increases when different corpora of written correspondences are interconnected and linked. Despite the strong need for common standards and common tools to exploit these connections and to reconstruct the discourse of the Republic of Letters, there is still no simple framework in the current panorama for publishing digitized correspondence corpora. The OPenPal project, led by Prof. Ghelardi, aims to develop a prototype system to manage, publish, export and visualise corpora of various types of correspondence in innovative ways: the idea is therefore to move from the EU-funded project EUROCORR (storing and displaying the critical edition of the correspondence to Jacob Burckhardt (1842-1897) – http://fe.burckhardtsource.org/ –) and to generalise both workflow and data model to new correspondence corpora, by refactoring and redesigning the architecture of Burckhardtsource. The expected outcomes of the OPenPal project will be to produce a prototype to publish digital correspondences (i.e. manuscripts, texts and data) and a toolkit to manage these special editions. OPenPal prototype will enable users to browse texts and data through guided paths, infographic visualisations, and will make it possible to browse a unique space of linked knowledge and trigger social mechanisms for discussion and debate on letters, thus opening from a niche of scholarly content to a wider audience. As a whole, this process will identify a sustainable business model for the new tool, based on linked data technologies in correspondence digital editions.

Mots-clés : correspondence corpora,unique browse space,common standards,open education resources,eurocorr data model,infographic visualisations,multilingual interface,new users categories
Projet ERC : AirKit (Horizon 2020, appel 2017, Proof of concept grants)
Entité participante : University of Cambridge — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : U. Cambridge
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 150000.0 €

In January 2013, the five-year ERC funded project Citizen Sense was launched, investigating the role of low-cost and digital monitoring technologies in facilitating and organising new types of environmental engagement. This proposal brings together a comprehensive citizen-sensing toolkit for users to undertake air quality monitoring that realises the social and environmental potential of these technologies. With the benefit of five years of intensive and cutting-edge research, the Citizen Sense research project is exceptionally well positioned to develop an AirKit, thereby bridging the gap between our research and the early stages of innovation in order to realise the innovation potential of the project. Our research pioneers new strategies of citizen-led monitoring and data analysis that join up hardware and software developments along with social innovations in order to produce an AirKit toolkit that has the potential to revolutionise community monitoring infrastructures and practices. This PoC will help to establish the viability of the AirKit, to refine and address technical issues, and to consolidate the overall direction of the AirKit.

Mots-clés : air quality monitoring,citizen sensing,diy technologies,environmental participation,citizen data
Projet ERC : AirKit (Horizon 2020, appel 2017, Proof of concept grants)
Entité participante : University of London — Pays : Royaume-Uni — Rôle : Partner
Acronyme de l'entité : U. London
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

In January 2013, the five-year ERC funded project Citizen Sense was launched, investigating the role of low-cost and digital monitoring technologies in facilitating and organising new types of environmental engagement. This proposal brings together a comprehensive citizen-sensing toolkit for users to undertake air quality monitoring that realises the social and environmental potential of these technologies. With the benefit of five years of intensive and cutting-edge research, the Citizen Sense research project is exceptionally well positioned to develop an AirKit, thereby bridging the gap between our research and the early stages of innovation in order to realise the innovation potential of the project. Our research pioneers new strategies of citizen-led monitoring and data analysis that join up hardware and software developments along with social innovations in order to produce an AirKit toolkit that has the potential to revolutionise community monitoring infrastructures and practices. This PoC will help to establish the viability of the AirKit, to refine and address technical issues, and to consolidate the overall direction of the AirKit.

Mots-clés : air quality monitoring,citizen sensing,diy technologies,environmental participation,citizen data
Projet ERC : PROVA (Horizon 2020, appel 2019, Proof of concept grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : Politecnico di Milano — Pays : Italie — Rôle : PI
Acronyme de l'entité : POLIMI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 150000.0 €

In a scenario of rising global energy needs, societal acceptance of renewable energy and yearning towards energy saving, the Organic Rankine Cycle (ORC) technology is playing a relevant role for a variety of renewable energy sources, from biomass to geothermal. ORC applications include also waste heat recovery from industrial processes, a segment with strong development potential. Due to the peculiarity of non-ideal flows in ORCs, measurements such as velocity, mass flow rate or turbine performance, which are routinely carried out in standard cycles and turbomachinery (e.g. gas turbines operating with air and combustion gases), are here very challenging. In addition, no appropriately calibrated instrumentation for non-ideal conditions are available, due to the lack of ad-hoc calibration facilities and calibration data. Such an instrument is key to the industry to improve the quality of their plant measurements and the overall energy conversion process. To tackle the aforementioned issues, the team has conceived a standardised methodology, taking advantages of the research facilities and of the developments on simulation tools carried out at the Laboratory of Compressible fluid dynamics for Renewable Energy Application (CREA, crealab.polimi.it) during the ERC Consolidator NSHOCK project, for the design and calibration of an accurate multipurpose probe for non-ideal flows, the Non-Ideal Pitot Probe (NIPP), for economical and independent instant data acquisition. A solution that raised the interest of the leading ORC players, representing over 90% of the market (see letters of interest) and of relevant manufacturer in close field of applications (oil & gas, compressors). Within the ERC PoC PROVA project, we intend to scale up the NIPP technology and accelerate its maturity level, thus assessing its technical and commercial feasibility. A prototipe of the NIPP probe, calibrated for a typical ORC working fluid (siloxane fluid MM), is the tangible outcome of the present proposal.

Mots-clés : non ideal compressible flows,pitot probe,renewable energy,organic rankine cycle,organic fluids