Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : NEW (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Mathematics
Entité participante : Université de Parme — Pays : Italie — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1495931.0 €

Project NEW tackles key challenges in nonlinear elliptic and parabolic regularity theory. The outcome answers to fundamental open questions. Achievements include sharp analysis data-solutions in nonuniformly elliptic or parabolic PDEs, singular set estimates in vectorial problems, and maximal regularity in degenerate (possibly nonlocal) monotone operators lacking strong monotonicity properties. These results are supported by innovative hybrid techniques, combining deep insights from harmonic analysis, nonlinear potential theory, and variational analysis, specifically devised to be implemented directly at the PDE level. Beyond technical and theoretical advances, the accomplishments will significantly impact Non-Newtonian fluid mechanics, homogenization, and geometric analysis, transforming techniques and perspectives developed through half a century of progress in nonlinear regularity theory.

Mots-clés : nonuniform ellipticity,nonlinear potential theory,regularity theory
Projet ERC : BeTASTy (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Life Science
Panel : Biotechnology and Biosystems E ngineering
Entité participante : Rede de Química e Tecnologia — Pays : Portugal — Rôle : PI
Acronyme de l'entité : REQUIMTE
Type d'entité : Recherche
Financement ERC de l'entité : 1499791.0 €

Taste properties are vital to humans: they impact human survival, nutrition, health and well-being. The problem of unpleasant taste properties, namely bitter- or astringent-tasting compounds is emerging in many diverse research fields. Beyond the obvious interest in food science, nutrition, and in the improvement/selection of crops, also human taste disorders and drug discovery domains could also benefit from research on astringency and bitterness. Crossing the boundaries among different fields, BeTASTy goes beyond the current state-of-the-art of food-oriented researches to respond to the prominent challenges on astringency and bitterness. This proposal will provide an in-depth mechanistic and functional understanding into the MAIN PHYSICAL-CHEMICAL EVENTS triggering the physiological and neural perception of astringency by an innovative approach considering the main oral key pieces namely salivary proteins, epithelia and emphasizing the role of mechanoreceptors on that sensation. BeTASTy will also unveil how, for some compounds, astringency and bitterness CAN GO TOGETHER by an innovative all-in-one model. Additionally, the individual features that account for sensory differences will be deepened by a pioneering approach based on human organoids and electroencephalography. The final goal, will be the creation of cutting-edge CELL-FREE BIOSENSORS based on the identified orally active mechano- and bitter taste receptors to assess astringency and bitterness respectively, and by overcoming the main drawbacks of the existing (cell-based) ones. Endowed with a truly differentiated and disruptive character, this groundbreaking project will engage food chemistry, biochemistry, neuroscience, sensory analysis and biotechnology fields of research to outdo the state-of-the-art. Only an ambitious and multidisciplinary proposal will yield scientific breakthroughs on the BIOCHEMICAL-NEURAL-PERCEPTUAL TRIAD EVENTS of these taste properties which will eventually enable to tailor them

Mots-clés : mechanoreceptors,organoids,inter individuality,cell free biosensors
Projet ERC : I-STREAM (Horizon Europe, appel 2023, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Texts and Concepts
Entité participante : Université Ca' Foscari de Venise — Pays : Italie — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1302500.0 €

For decades, Caribbean musics have seen unparalleled global popularity, becoming key to the region’s tourism economy. Yet today, Caribbean live music scenes are in peril, reeling from recurring climate-related disasters. In light of music’s centrality to Caribbean tourism economies and cultural life and the increasing frequency and severity of climate related events, the stakes for understanding the role of live music in recovery processes is particularly high. Focusing on three urban contexts - San Juan (Puerto Rico), Kingston (Jamaica), and Havana (Cuba) - I-STREAM will investigate the impact of climate disaster on the long-term rhythms of musical activity – the location, frequency and content of live music in the Caribbean. Responding to methodological challenges affecting research in disaster contexts – such as the displacement of local population and cultural spaces – I-STREAM will integrate ethnographic research with analysis of online concert videography - videos taken in the course of performance and uploaded to online platforms – to analyze musical and geo-temporal data on processes of change and recovery following the occurrence of climate-related disasters. This will complement participatory on-site research and input from local stakeholders (concert goers, musicians and industry professionals) and will shed new light on the changing frequency and diversity of live music performances, a crucial index of displacement and touristification following major disasters in contexts - such as the Caribbean - where music holds a fundamental role in sustaining the economy and in the lives of local inhabitants.

Mots-clés : caribbean music,tourism,climate related disaster,long term rhythms,music scenes,climate migration
Projet ERC : COREDIM (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Human Mind and Its Compl exity
Entité participante : Société Max-Planck pour le développement des sciences — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : Société Max Planck
Type d'entité : Recherche
Financement ERC de l'entité : 360000.0 €

Our ability to interact with our visual world is a remarkable feat: Despite drastic changes in their visual appearance, we can effortlessly make sense of thousands of objects and carry out meaningful actions on them. To understand the nature of our visual representations that underlie this ability, a central goal of cognitive neuroscience is to determine the properties – or dimensions – that make up our representational space of objects. While much progress has been made at identifying the building blocks of visual processing in brain and cognition, our scientific understanding of visual representations remains fundamentally limited by (1) our ability to capture the complexity and variability of our visual world for determining the dimensions underlying our object representations and (2) the difficulty in disentangling visual and semantic contributions to these representations. COREDIM is an ambitious, interdisciplinary program that aims at overcoming these limitations and provide a detailed, interpretable characterization of the core dimensions underlying visual object representations. To reach this goal, COREDIM capitalizes on extensive, targeted sampling of behavioral and neuroimaging data and cutting-edge artificial intelligence methods that allow the identification of interpretable representational dimensions. Project 1 aims at uncovering the core representational dimensions of objects across ventral visual cortex, using a biologically-inspired neural network model tailored to each individual’s functional neuroanatomy and trained to identify the most informative stimuli. Project 2 will identify the relative role of vision and semantic knowledge in shaping our core representational dimensions, through experimental manipulations at the level of the stimulus, task, and with cross-species comparisons. Together, COREDIM promises to transform our understanding of visual processing, laying the foundation for a comprehensive characterization of visual cortex function.

Mots-clés : object recognition vision perception representation fmri meg
Projet ERC : LIRICO (Horizon Europe, appel 2023, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Fundamental Constituents of Matter
Entité participante : Société Max-Planck pour le développement des sciences — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : Société Max Planck
Type d'entité : Recherche
Financement ERC de l'entité : 360943.64 €

Ultracold molecules are the next frontier of quantum technologies: their rich internal structure and tunable long-range interactions enable the exploration of new regimes, unattainable with atomic platforms. Achieving this control requires cooling to ultracold temperatures. However, ultracold molecular interactions are dominated by lossy chemical reactions. Chemical reactions hamper the quantum applications of molecular gases and our strategies to reach the ultracold temperature limit, including the realization of the holy grail of ultracold molecular physics: a Bose-Einstein Condensate of polar molecules. Recently, I successfully developed several shielding mechanisms to protect polar molecules from chemical reactions and exploited them to realize the first quantum degenerate Fermi gas of molecules by direct evaporation. In LIRICO, I will leverage on these previous results to control the chemical reactions of ultracold molecules and thus unlock the full potential of molecular quantum gases. A high-finesse optical cavity will be the fulcrum of LIRICO to tame chemical reactions. Strong light-molecule coupling will create new hybrid light-molecule states, so called molecular polaritons, that will display the ability to turn on-and-off a chemical reaction by simply controlling the molecule-cavity resonance. The addition of final-state sensitive detection methods, such as an ion-mass spectrometer, will allow to fully resolve the microscopic mechanisms that underpin ultracold reactions. I will steer the reaction dynamics at will and control the reaction product distribution with the cavity vacuum, thus realizing a paradigm-changing, fully quantum-mechanical catalysis method for controlling the transformation of molecular materials. Cavity-control of ultracold chemical reactions will open new avenues in the dissipation engineering of inelastic and out-of-equilibrium processes, which is crucial for the development of molecular quantum technologies.

Mots-clés : ultracold chemistry,molecular polaritons
Projet ERC : ELECTROCOFS (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Materials Engineering
Entité participante : Université d'Aveiro — Pays : Portugal — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 240236.25 €

A major breakthrough in chemistry and materials science has been the development of Lithium-Ion Batteries (LIBs), which show great potential for storing energy from renewable sources and as the power sources for electric cars. However, commercially available LIBs are based on transition metal oxide cathodes, presenting limited energy density and raising relevant environmental concerns. Organic materials have received much attention as alternative electrodes because of their high theoretical capacity, resources availability and sustainability. In particular, Covalent Organic Frameworks (COFs) have emerged in the past few years as promising organic electrode materials due to their high stability, high ionic conductivity and outstanding chemical and structural versatility. Low electrical conductivity remains the main bottleneck for real applications of COFs as electrode materials, usually addressed by adding in large amounts of conductive carbon additives that decrease the energy density of the battery. The overarching objective of this project is to design and synthesize new conductive redox-active COFs as cathode materials to enhance LIBs electrochemical performance. The specific goals are: a) To design a new family of stable redox-active COFs built from unexplored building blocks to achieve an optimal balance between capacity, electrical conductivity and porosity. b) To investigate the role of the linkages, building blocks, doping, pressure, anisotropy and morphology on the electrical conductivity, unravelling the fundamental mechanisms of charge transport in COFs. c) To manufacture and test lithium batteries using conductive COFs cathode materials, assessing the influence of the processing techniques on the electrochemical performance.

Mots-clés : covalent organic frameworks electrical conductivity energy storage lithium ion batteries
Projet ERC : DESignSX (Horizon Europe, appel 2023, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and Processes Engineering
Entité participante : Université d'Aveiro — Pays : Portugal — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499851.0 €

DESignSX proposes the application of bio-inspired non-ionic hydrophobic eutectic solvents (DES) to the solvent extraction (SX) separation of lanthanides (Ln) based on the understanding of these complex mixtures that are defined by hydrogen-bonded supramolecular self-assembly. Sustainable metallurgy stands uniquely poised to reduce the environmental impact of existing processes whilst recovering the metal value in end-of-life devices, thereby closing the resource loop. Despite their growing demand and geopolitical criticality, Ln separation remains technologically challenging due to the small monotonic variation in their properties, negatively affecting the economics of their recycling. DESignX seeks to exacerbate the steric factors defining the interactions between Ln and ligands, dictating the ensuing complex geometries and mutual separation selectivity, through the inclusion of complexing agents as components of molecularly crowded DES. By carefully selecting the DES phase binary components, the energy penalty associated with the structuration of the apolar phase may be rationally adjusted to increase the selectivity between adjacent Ln versus the same extractant in conventional SX. Given that the separation of adjacent Ln occurs over dozens of counter-current extraction stages, even seemingly small increases in the separation factors yield measurable environmental and economic gains. DESignSX rely on a tandem experimental-computational approach spanning multiple time and size scales, from a molecular description of pair-wise interactions to laboratory-scale process optimisation. DESignSX will overcome the traditional SX issues of complex flowsheets, third-phase formation, toxicity of the organic diluent through the inclusion of bio-derived components, and entrainment losses, whilst improving the selectivity of the separation. DESignSX outcomes are expected to be transferable to other critical SX separations.

Mots-clés : hydrometallurgy solvent extraction lanthanide separation deep eutectic solvents circular economy
Projet ERC : PolFam (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Université de Bath — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1481283.75 €

Famines are becoming more frequent and deadly, with 250,000 people experiencing famine in 2022 and 35 million people being on the edge of famine. For decades there has been a scholarly consensus that famine is the result of political failure or design, and never solely the result of natural disasters. However, a political culture that makes famine politically unconscionable and that ends famine has not emerged. To understand why famines persist we need to deepen our understanding of famine politics; so far scholarship on the politics of famine has focus on national and international institutions, and the instrumental use of famine by actors and institutions. My research will produce a ground-breaking shift in the science of famine politics by focusing on the everyday politics of famine in communities where it occurs. I am interested in how discourses and the ‘regime of truth’ about famine disperse throughout the social body (in Foucault’s words). In particular, I am interested in how new deadly famines come to be normalised, preventing political rupture. Plus, I am interested in how these discourses can shift blame for famine suffering away from governments, warring parties and actors in global economies, and instead place blame on natural causes and the families of those who suffer and die. To achieve this, I will conduct an ethnographically-informed comparative study across four sites in South Sudan and in Somalia. Initial ethnographic insights have made me structure the research around four cross-case-study research strands: histories and musical memories of past famine; community-narratives that enforce social networks; burial and posthumous practices; and media and social media’s role in anti-famine politics. This ambitious project is feasible because of my previous experience and networks, and because I have carefully built the capacity and track record of a team Somali and South Sudanese – dominated research team.

Mots-clés : famine everyday
Projet ERC : SweetEggs (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Life Science
Panel : Physiology in Health, Disease and Ageing
Entité participante : Gulbenkian Institute for Molecular Medicine — Pays : Portugal — Rôle : PI
Acronyme de l'entité : GIMM
Type d'entité : Recherche
Financement ERC de l'entité : 1481513.0 €

Animals are composed of multiple tissues with different metabolic needs. During differentiation, the establishment of specific metabolic programs allows cells to acquire specialized functions. The nutrients that fuel these cell-specific metabolic pathways are obtained via the diet. In order to secure proper nutrient supply to these tissues, the central nervous system accesses their metabolic states, allowing the animal to mount behavioral strategies to adapt nutrient appetite. Our understanding of how cell-specific metabolic programs regulate animal physiology and behavior has been hindered by the lack of tractable experimental systems. Using Drosophila melanogaster I uncovered that the germline undergoes metabolic reprogramming, upregulating a specific carbohydrate metabolism branch, the pentose phosphate pathway (PPP) and that oogenesis progression requires the supply of dietary sugars, fueling this pathway. I further showed that the germline communicates its metabolic status to the fat body (FB), regulating the transcription of a satiety factor that acts on the brain to regulate sugar appetite. These findings represent a unique experimental platform, which I will use to study how cell-specific metabolic programs and nutrition regulate whole-animal animal physiology and fertility. I will: 1) identify the transcriptional factors regulating metabolic reprogramming in the germline; 2) test the requirement of specific PPP metabolites in germline cell functions and fertility; and 3) identify the molecules mediating the ovary-FB signaling axis and characterize their impact on FB transcriptional regulation, nutrient appetite, and fertility. Metabolic dysfunctions are known to result in many human conditions. This proposal will not only contribute to our understanding of how metabolism ensures reproduction, but will also help developing dietary interventions to tackle impactful human disorders including infertility.

Mots-clés : metabolic programs,germline,fertility,inter organ communication,diet,drosophila,oogenesis,nutrient appetite,pentose phosphate pathway
Projet ERC : HOW2DOUBLE (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Life Science
Panel : Environmental B iology, Ecology  and E volution
Entité participante : Société Max-Planck pour le développement des sciences — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : Société Max Planck
Type d'entité : Recherche
Financement ERC de l'entité : 1493898.0 €

Many eukaryotes have more than two sets of chromosomes due to whole-genome duplication (WGD) and are called polyploids. WGDs explain many cases of speciation bursts and evolutionary inventions. Some evidence suggests an adaptive advantage of polyploids: the origins of many ancient WGDs correspond to the times of extreme climate change, and contemporary polyploids often occupy harsher environments compared to their ancestors. However, most new polyploids are not as lucky and rarely survive. To explain the cause, predict and manipulate this process, we need to understand the basic principles of polyploidy: (1) how it is triggered, (2) what enables the initial survival of newly formed polyploids, and (3) how they stabilize a population and become successful. My program will comprehensively cover all these aspects, from the functional and genetic levels to the evolutionary forces driving the entire process. I propose a cross-disciplinary approach to identify common polyploidy principles in plant and animal diploid-tetraploid species complexes: Arabidopsis lyrata, widespread plant in Northern Hemisphere, and Neobatrachus, burrowing frogs living in the Australian desert. The approach combines classic genetics with the latest genomics technologies and population genetics analysis of natural herbarium and museum collections across broad geographies. I will (1) expose genetic and environmental predispositions to polyploidy formation by mapping natural variation of the unreduced gametes rates; (2) reveal mechanics and genetics stabilizing meiosis in polyploids, comparing recombination and selection across ploidies; (3) uncover polyploid populations recovery processes after bottlenecks accompanying their origin by reconstructing introgression patterns. Deciphering the mechanisms leading to successful polyploidization across the plant and animal kingdoms will deliver groundbreaking advances relevant across biology, agriculture, and medicine.

Mots-clés : polyploidy,meiosis,adaptation,introgression,population genetics,cytology