Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : DissectCMV (Horizon 2020, appel 2019, Consolidator grants)
Domaine scientifique : Life Science
Panel : Immunity, Infection and Immunotherapy
Entité participante : Weizmann Institute of Science — Pays : Israël — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2000000.0 €

The herpesvirus human cytomegalovirus (HCMV), the largest known human virus, is a ubiquitous pathogen that persistently infects the majority of the world's population through the establishment of latency. Although asymptomatic in most healthy individuals, HCMV can lead to a severe congenital disease, as well as morbidity and mortality in immunocompromised adults. Despite the prevalence and pathogenicity of HCMV, many fundamental questions about this pathogen remain open. We still do not know the complete list of functional elements in HCMV's complex genome and how these contribute to infection progression and latency, we do not understand the determinants that govern infection outcome, and we are missing tools that will facilitate systematic dissection of the host and viral factors that are needed for HCMV infection in different cell types. In this proposal, we suggest to employ our expertise and to develop unique toolsets to shed light on the host and viral factors that regulate the HCMV life cycle. We propose to combine state-of-the art high-throughput tools with mechanistic studies to comprehensively characterize the viral elements that regulate HCMV progression (aim 1), decipher the determinants that dictate infection outcome (lytic vs. latent, aim 2) and develop and implement a sensitive screening platform that will facilitate easy dissection and characterization of HCMV essential components in any cell type (aim 3). The knowledge generated from these objectives will provide a clearer depiction of the different determinants that control HCMV infection and will generate new tools for the benefit of the community. These in turn could help to expand our therapeutic options. More broadly, with its comprehensive and complementary approaches, this work will provide a paradigm for the study of other herpesviruses and for understanding complex host-pathogen interactions.

Mots-clés : cytomegalovirus,herpesviruses,crispr,latency,translation regulation,transcriptomic
Projet ERC : DeCode (Horizon 2020, appel 2017, Consolidator grants)
Domaine scientifique : Life Science
Panel : Neuroscience and Disorders of the Nervous System
Entité participante : Hungarian Academy of Sciences — Pays : Hongrie — Rôle : PI
Acronyme de l'entité : MTA
Type d'entité : Recherche
Financement ERC de l'entité : 1990314.0 €

The hippocampus is essential for building episodic memories. Coding of locations, contexts or events in the hippocampus is based on the correlated activity of neuronal ensembles; however, the mechanisms promoting the recruitment of individual neurons into information-coding ensembles are poorly understood. In particular, the recurrent synaptic network of pyramidal cells (PCs) in the hippocampal CA3 area, receiving external inputs from the entorhinal cortex and the dentate gyrus, is thought to be essential for associative memory. Current models of the associative functions of CA3 are mainly based on plasticity of these synaptic connections. Recent work by us and others however suggests that active, voltage-dependent properties of CA3PC dendrites may also promote ensemble functions. Dendritic voltage-dependent ion channels allow nonlinear amplification of spatiotemporally correlated synaptic inputs (such as those produced by ensemble activity) and can even generate local dendritic spikes, which may elicit specific action potential patterns and induce synaptic plasticity. Furthermore, dendritic processing may be modulated by activity-dependent regulation of dendritic ion channels. However, still little is known about the active properties of CA3PC dendrites and their functions during spatial coding or memory tasks. The general aim of my research program is to understand the cellular mechanisms that underlie the formation of hippocampal memory-coding neuronal ensembles. Specifically, we will test the hypothesis that active input integration by dendrites of individual CA3PCs plays an important role in their recruitment into specific context-coding ensembles. By combining in vitro (patch-clamp electrophysiology and two-photon (2P) microscopy in slices) and in vivo (2P imaging and activity-dependent labelling in behaving rodents) approaches, we will provide an in-depth understanding of the dendritic components contributing to the generation of the CA3 ensemble code.
Projet ERC : FORMSofLABOUR (Horizon 2020, appel 2018, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Exeter — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1611639.0 €

The history of labour and its role in Europe’s preindustrial development has very largely been the history of adult men. FORMSofLABOUR seeks to put other workers in the picture, particularly women and servants, not simply by ‘adding them on’ but by showing how a full understanding of women’s work and of service offers a radical critique of existing approaches to work and to the idea of free labour. It focuses on England in the period 1300-1700 viewed in a comparative Western European perspective, and addressed these issues through three themes. (1) A revolutionary research technique which collects evidence of work tasks from court records to simulate a time-use study is used to explore the experience of work. This technique allows the work activities of women and men, young and old, employees and family members to be illuminated, with evidence of tasks, location and timing of work, creating an entirely new perspective on England’s early modern economy. (2) The theoretical underpinnings of the history of women’s work in the preindustrial economy are explored, reassessing key debates using interdisciplinary perspectives from economics and political science, as well as new archival evidence from themes 1 and 3. Gendered work patterns are viewed through the lens of freedom, rather than patriarchy, to create a step-change in our understanding of gender and work. (3) The issue of the extent to which labour was ‘free’ after the end of serfdom is interrogated through a careful examination of the range of forms of labour and the nature of labour laws, using a variety of archival evidence combined with a comparisons with serfdom and slavery, and the adoption of insights from development economics and anthropology. Together these interlocking themes create a new history of work in the economy which formed the background to grand narratives of Smith and Marx, arguing that with women and servants had been in picture, the story of economic development is transformed.

Mots-clés : work,labour,gender,freedom,labour laws,servants,household economy,youth,women,time use
Projet ERC : Global Horizons (Horizon 2020, appel 2017, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : University of Bern — Pays : Suisse — Rôle : PI
Acronyme de l'entité : UB
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1904188.0 €

The horizon is the line that seems to separate earth from sky, the line that divides all visible categories into two categories: those that intersect the earth’s surface and those that do not. The horizon is key to the experience of space; it defines our perspective on the visible world. The GLOBAL HORIZONS project will investigate the historical meanings and functions of the horizon in visual and intellectual cultures of the pre-Modern world on a global scale. Examining how pre-Modern cultures conceived of the horizon opens a crucial line of inquiry into understanding the many different ways in which humans have conceived of the relationship between an invisible cosmos and the visible world. Non-western art history is rarely taught at European institutions although countless important works of Non-Western art are kept in museum collections all across Europe. Including non-western concepts of pictorial space is key to the project, however, for Eurocentric models of art history have generally privileged the rise of the linear perspective. This framing has limited our understanding of the horizon’s complex rhetorical, visual and epistemological roles. The project’s specific question connects a variety of objects and epistemological categories, such as panel painting, manuscript illumination, profane und religious objects, cartography, travel accounts, and cosmological treaties. The applied methodological approaches will range from art history, visual studies and cultural anthropology. They will also draw upon interdisciplinary expertise, such as technologies of art production, history of science and philosophy. The project thus makes an important contribution to global art history, a highly innovative area in which only very few pre-modern topics have been addressed. It is the ultimate goal of GLOBAL HORIZONS is to suggest a new history of representation in Western medieval art.

Mots-clés : globalization,pre modern culture,transcultural exchange,horizon,perspective,painting,urban spaces,life world,representation
Projet ERC : PEGASUS (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Exeter — Pays : Royaume-Uni — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 46593.75 €

The horse provided us with rapid transportation, an almost unrivaled secondary product that tremendously impacted the politico-economical trajectory of our societies, revolutionizing the circulation of ideas, people, languages, religions and communication. Horse chariotry and cavalry also changed warfare and beyond the battlefield new equestrian technologies have stimulated agricultural productivity. However, the 5,500 year long history of horse domestication and management, which transformed the natural evolutionary trajectory of wild horses into the more than 625 domestic breeds living today, is difficult to reconstruct from archaeology, history and modern genetics alone. Yet, with archaeogenetics, one can access the genetic information from past individuals and track in great detail past population trajectories. In this project, I propose to build on the latest advances in the analysis of ancient DNA molecules to gather new genomic, epigenomic and metagenomic information from ancient horses. This will be integrated with archaeozoological, isotopic and historical data to enhance our understanding of the multiple processes underlying the transformation of the animal that perhaps most impacted our history. Starting from the characterization of pre-domestic populations of wild horses, I will evaluate the genomic and dietary impact of early domestication stages and will explore whether horses were independently domesticated in Iberia and the Pontic-Caspian steppe. I will follow how the emergence of chariotry and the development of heavy cavalry impacted the horse’s behavioural, physiological and biological makeup. I will reveal the horse characteristics that were preferred in various historical contexts and will investigate a diversity of management strategies and husbandry conditions to reveal their impact on horses, from classical and late antique periods until the recent creation of modern breeds by means of intensive selective breeding.

Mots-clés : ancient dna,horse domestication,animal management,animal husbandry,evolutionary genomics,diet,artificial selection,natural selection,biological adaptation
Projet ERC : TRAIN-OLD (Horizon 2020, appel 2018, Advanced grants)
Domaine scientifique : Life Science
Panel : Physiology in Health, Disease and Ageing
Entité participante : Elliniko instituto meletis tis sipsis — Pays : Grèce — Rôle : Partner
Acronyme de l'entité : Hellenic institute for the study of sepsis
Type d'entité : Recherche
Financement ERC de l'entité : 237500.0 €

The host defense, especially the adaptive immunity, is defective in the elderly, with a dramatic drop for the efficacy of vaccination with old age. Interestingly however, the innate immunity of older individuals is relatively intact, and we recently described that epigenetic and functional reprogramming of innate immune cells by certain vaccines and mild infections, termed ‘trained immunity’, induces potent heterologous protection against infections. I propose that induction of trained immunity is an important novel approach to improved vaccination in the elderly. Induction of trained immunity is regulated by the interaction between the host genome, microbiome, and the epigenetic and metabolic programs of specific populations of myeloid cells, and we need to understand how these factors are impacted by age and gender of the host. By understanding the factors that impact the response to BCG (Bacille Calmette-Guerin), the prototype vaccine that induces trained immunity, we will be able to design better vaccines for the elderly. The Key objectives of the project are: Key objective 1: To describe the innate immune cell (sub)populations, and their heterogeneity at single-cell level, responsible for mediating trained immunity in the young and elderly adults. Key objective 2: To identify the complex genetic, epigenetic, microbiome, and metabolic programs that represent the molecular and biochemical substrates of trained immunity in the myeloid cells of the elderly individuals. Key objective 3: To use systems biology to map the heterogeneity of trained immunity response determined by host (epi)genome, microbiome, and environmental factors in the elderly. Expected results: We will understand the main cellular and molecular mechanisms for the induction of trained immunity responses in vivo and the specificities of the response in the elderly. These findings will enable the design of innovative approaches to improve vaccination strategies.

Mots-clés : immune senescence,vaccination,innate immune memory,trained immunity
Projet ERC : TRAIN-OLD (Horizon 2020, appel 2018, Advanced grants)
Domaine scientifique : Life Science
Panel : Physiology in Health, Disease and Ageing
Entité participante : Radboud University Nijmegen — Pays : Pays-Bas — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

The host defense, especially the adaptive immunity, is defective in the elderly, with a dramatic drop for the efficacy of vaccination with old age. Interestingly however, the innate immunity of older individuals is relatively intact, and we recently described that epigenetic and functional reprogramming of innate immune cells by certain vaccines and mild infections, termed ‘trained immunity’, induces potent heterologous protection against infections. I propose that induction of trained immunity is an important novel approach to improved vaccination in the elderly. Induction of trained immunity is regulated by the interaction between the host genome, microbiome, and the epigenetic and metabolic programs of specific populations of myeloid cells, and we need to understand how these factors are impacted by age and gender of the host. By understanding the factors that impact the response to BCG (Bacille Calmette-Guerin), the prototype vaccine that induces trained immunity, we will be able to design better vaccines for the elderly. The Key objectives of the project are: Key objective 1: To describe the innate immune cell (sub)populations, and their heterogeneity at single-cell level, responsible for mediating trained immunity in the young and elderly adults. Key objective 2: To identify the complex genetic, epigenetic, microbiome, and metabolic programs that represent the molecular and biochemical substrates of trained immunity in the myeloid cells of the elderly individuals. Key objective 3: To use systems biology to map the heterogeneity of trained immunity response determined by host (epi)genome, microbiome, and environmental factors in the elderly. Expected results: We will understand the main cellular and molecular mechanisms for the induction of trained immunity responses in vivo and the specificities of the response in the elderly. These findings will enable the design of innovative approaches to improve vaccination strategies.

Mots-clés : immune senescence,vaccination,innate immune memory,trained immunity
Projet ERC : MULTICONNECT (Horizon 2020, appel 2014, Starting grants)
Domaine scientifique : Life Science
Panel : Neuroscience and Disorders of the Nervous System
Entité participante : Maastricht University — Pays : Pays-Bas — Rôle : PI
Acronyme de l'entité : UM
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1500000.0 €

The human brain is one of the largest and most complex biological networks known to exist. The architecture of its circuits, and therefore the computational basis of human cognition, remains largely unknown. The central aim of this proposal is to image human cortical connectivity at multiple spatial scales in order to understand human cortical computations. Whereas canonical cortical microcircuits are an established theory of the repeating structure of the neocortex’s circuits, predictive coding provides a prominent proposal of what these circuits compute. This leads to the core hypothesis of this proposal: the variations in predictive coding computations performed by human cortical microcircuits in different visual areas are grounded in variations in their microcircuit connectivity. As a central case-study, this proposal investigates human visual apparent motion perception in V1/2/3 and V5/MT+. The proposed research program is organized in two workpackages (WP I and II). WP I has the aim of imaging the multiscale connections of human neocortical microcircuits. The projects in WP I focus on structure and move from the mesoscale down to the microscale. WP II has the aim of modelling how microcircuits support predictive coding computations. The projects in WP II focus on function and move from the microscale back up to the mesoscale. Structural and functional assessment of microcircuitry in the human brain only recently became possible with the development of magnetic resonance imaging (MRI) at ultra-high field-strengths (UHF) of 7T and above. UHF diffusion MRI, combined with light microscopy, is used to image circuit structure in WP I. UHF functional MRI is used for computational modelling of computations in WP II. Successful completion of the planned research will significantly advance our understanding of the computations in cortical microcircuits, deliver important new human connectomic reference data, and improve generative models of human cortical processing.

Mots-clés : connectomics,magnetic resonance imaging,light microscopy,generative fmri modeling,computational neuroscience
Projet ERC : SEXHUM (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Kingston University — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : KUL
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1341765.0 €

The humanitarian fight against trafficking in the sex industry legitimizes the enforcement of increasingly restrictive migration laws and controls, which often exacerbate sex workers’ vulnerability to being trafficked. SEXHUM adopts an art-science interdisciplinary approach bringing together visual anthropology, sociology, gender and queer studies and human geography to study the relationship between migration, sex work, exploitation and trafficking. It contextualizes this relationship within the global onset of sexual humanitarianism, a concept coined by the PI. It refers to the ways migrants are increasingly represented, understood and targeted by the media, policymakers and social interventions as vulnerable to exploitation and abuse in relation to their sexual orientation or behaviour. SEXHUM adopts a migration studies perspective and a participative approach to focus on migrant sex workers addressed by sexual humanitarianism as victims of trafficking. It reappraises the concepts of exploitation, slavery and trafficking through the lens of how they are understood and experienced by migrants. The project analyses the global emergence of humanitarian migration governance by examining the impact of sexual humanitarianism across six strategic urban settings in Europe (France – Marseille and Paris), the US (New York and Los Angeles), Australia (Sydney) and New Zealand (Auckland) that are characterized by different policies on migration, sex work (criminalisation, regulation, de-criminalisation) and trafficking. The innovative method developed by the PI combines ethnographic observations, semi-structured interviewing and participative filmmaking to address the narrated as well as the affective, relational and performative dimensions of migrants’ experiences of agency and exploitation. The research will generate needed user-based data on the impact of anti-trafficking initiatives that will be highly relevant to policymaking.

Mots-clés : migration,prostitution,trafficking,social interventions,agency,exploitation
Projet ERC : ISLAS (Horizon 2020, appel 2017, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Earth system science
Entité participante : University of Bergen — Pays : Norvège — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1999054.0 €

The hydrological cycle, with its feedbacks related to water vapour and clouds, is the largest source of uncertainty in weather prediction and climate models. Particularly processes that occur on scales smaller than the model grid lead to errors, which can compensate one another, making them difficult to detect and correct for. Undetectable compensating errors critically limit the understanding of hydrological extremes, the response of the water cycle to a changing climate, and the interpretation of paleoclimate records. Stable water isotopes have a unique potential to serve as the needed constraints, as they provide measures of moisture origin and of the phase change history. We have recently spearheaded a revised view of the atmospheric water cycle, which highlights the importance of connections on a regional scale. This implies that in some areas, all relevant processes can be studied on a regional scale. The Nordic Seas are an ideal case of such a natural laboratory, with distinct evaporation events, shallow transport processes, and swift precipitation formation. Together with recent technological advances in isotope measurements and in-situ sample collection, this will allow us to acquire a new kind of observational data set that will follow the history of water vapour from source to sink. The high-resolution, high-precision isotope data will provide a combined view of established and novel natural isotopic source tracers and set new benchmarks for climate models. A unique palette of sophisticated model tools will allow us to decipher, synthesize and exploit these observations, and to identify compensating errors between water cycle processes in models. In ISLAS, my team and I will thus make unprecedented use of stable isotopes to provide the sought-after constraints for an improved understanding of the hydrological cycle in nature and in climate models, leading towards improved predictions of future climate.

Mots-clés : atmospheric water cycle