Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : HPDR (Horizon Europe, appel 2021, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Mathematics
Entité participante : Institute of Mathematics, Physics, and Mechanics — Pays : Slovénie — Rôle : Partner
Acronyme de l'entité : IMFM
Type d'entité : Recherche
Financement ERC de l'entité : 310092.5 €

The aim is to develop an emerging field of complex analysis and geometry focused on holomorphic partial differential relations (HPDR). Such a relation of order r is given by a subset of the manifold of r-jets of holomorphic maps between a pair of complex manifolds, and the main question is when does a formal solution lead to an honest analytic solution. This complex analogue of Gromov’s h-principle is highly important but poorly understood. The project will focus on the following problems.  (A) Oka theory concerns the existence and approximation of holomorphic maps from Stein manifolds to complex manifolds, corresponding to HPDRs of order zero. The central notion of Oka theory is Oka manifold; this is a complex manifold such that the h-principle holds for maps from any Stein manifold into it. Recently developed techniques give a promise of major new developments on Oka manifolds and their applications to a variety of problems in complex geometry. (B) Open first order HPDRs. Oka-theoretic methods will be applied in problems concerning holomorphic immersions and locally biholomorphic maps.  (C) First order HPDRs defined by analytic varieties in the jet bundle. Application of Oka-theoretic methods in holomorphic directed systems, with emphasis on complex contact manifolds and holomorphic Legendrian curves.  (D) Applications of Oka theory to minimal surfaces. Development of hyperbolicity theory for minimal surfaces. The Calabi-Yau problem for minimal surfaces in general Riemannian manifolds. Study of superminimal surfaces in self-dual Einstein four-manifolds via the Penrose-Bryant correspondence. These closely interrelated topics embrace major open problems in three fields, with diverse applications.

Mots-clés : oka manifold,stein manifold,complex contact manifold,minimal surface
Projet ERC : MENBELONG (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Soci al World and Its Interactions
Entité participante : Université pontificale catholique du Chili — Pays : Chili — Rôle : Partner
Acronyme de l'entité : PUC
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 92500.0 €

The successful integration of migrant populations requires that individuals who permanently relocate to a host country develop a sense of belonging. This involves not only economic and legal integration, but also the sharing of values, practices, and social networks with others. Single men form the largest group within global migration flows but face the harshest challenges to successful integration and belonging. They are frequently viewed as taking away opportunities from citizens and are deprioritized in social services in favour of families and women. They are also often stereotyped as hypersexualized or criminal. In the face of these obstacles, single migrant men create a range of unique belonging strategies that take place outside family networks and formal integration processes. Yet existing migration research tends to focus on the experience of women and families and the integration of specific groups of migrant men (usually Muslim) in Western democracies. As a result, we know very little about how single migrant men develop a sense of belonging outside of these restricted contexts. In this project, I investigate single migrant men’s experiences of belonging across five countries that have experienced abrupt, large-scale migration flows and that have different gender equality levels and integration policies. These groups include Syrians in Türkiye, Mexicans in Canada, Turks in Germany, Myanmarese in Thailand, and Venezuelans in Chile. My team includes country experts from the disciplines of migration studies, anthropology, sociology, gender studies, and community mental health with expertise in archival research, experimental surveys, interviews and photovoice. I draw on these perspectives to develop a theory of migrant belonging. This comprehensive approach will impact theories of migration and gender by providing intersectional and international insights into how single migrant men develop a sense of belonging in the face of serious challenges.

Mots-clés : masculinity,intersectionality,belonging,stigma,mixed methods research,non eu countries
Projet ERC : RESOUND (Horizon Europe, appel 2022, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Texts and Concepts
Entité participante : Université polytechnique de Madrid — Pays : Espagne — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 195750.0 €

Plainchant, the sacred Christian chant, is the most ancient Western corpus preserved in musical notation. Before the unifying adoption of the Gregorian liturgy throughout Europe in the 9th century, a number of liturgical families –each one with its own chant repertoire– emerged in the ancient Western Roman provinces. Among them, the Hispanic liturgy was recorded –text and music– in manuscripts between ca. 700 and ca. 1300. These sources allow us to know the liturgy’s ceremonies and texts, but not the melodies themselves. In fact, notational signs do not indicate the specific intervals between the notes, since they were written prior to the use of a notational system in which each individual sign contains precise pitch information. As a consequence, the Hispanic musical notation is considered indecipherable and its thousands of melodies still remain silent.  RESOUND aims to achieve what has so far been considered an impossible task: bringing to life the sounds of Hispanic chant. To accomplish this goal, we will use tools from the fields of bioinformatics, genetics, computational analysis, aural architecture and virtual restoration of sound and images, along with tools from the humanities, including musical performance. Computational analysis aside, these tools have never been used in the study of medieval chant, let alone in combination. By recovering the sounds of Hispanic chant and establishing these innovative methods, we will be able to offer new understandings of the generative and evolutionary dynamics of the European plainchant repertoires. In this way, we will not only recuperate the Hispanic melodies, but also restore a significant part of the soundscape of medieval Europe. Thus, by reversing the standard approach via focusing on a territory considered peripheral, we will shed new light on the process of cultural creation in the European Middle Ages.

Mots-clés : digital humanities,big data,computational analysis,plainchant,medieval music,creation processes
Projet ERC : SevenFrontiers (Horizon Europe, appel 2023, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Study of the Human Past
Entité participante : Académie royale néerlandaise des arts et des sciences — Pays : Pays-Bas — Rôle : PI
Acronyme de l'entité : KNAW
Type d'entité : Recherche
Financement ERC de l'entité : 2500000.0 €

Our lives would be unthinkable without the production of millions of tons of cotton, sugar, palm oil or soy. All these commodities are obtained at the lowest possible price with often detrimental consequences for people and nature. The scale of the resulting environmental crises may be something of recent making, its mechanisms can be traced many centuries ago and are crucially part of the history of global capitalism. This project will go back to the pivotal decades when Europe recovered from the devastating Napoleonic wars, the Industrial Revolution picked up steam and global trade went through fifty years of rapid growth, a spurt even more spectacular than after the opening of the Suez Canal in 1869. Against this backdrop the project’s research team will examine the immense transformative effects of commodity frontiers in the Global South that fed the rise of early industrial capitalism. We will assess these transformations by taking the seven most exported commodities from the Global South as the unit of analysis (sugar, cotton, coffee, tea, precious metals (gold/silver), opium and cereals). We will map the wide-ranging and diverse social consequences of the massive mobilization of labour and land necessary to produce these commodities using an extensive historical database on global labour relations developed by an international group of scholars. We will further examine how these commodity frontiers were organized and financed by using underutilized archives of prominent locally and globally operating merchant houses. Finally, we will assess the actual contribution of the production of the seven commodities in the Global South to the upsurge of global trade. Data mining from digitized sources such as newspapers will allow us to identify trade patterns that so far escaped historical statistics. Thus, we will break new grounds in understanding how early on in the nineteenth century global trade and production patterns emerged that shaped the world of today.
Projet ERC : EPICURE (Horizon Europe, appel 2023, Advanced grants)
Domaine scientifique : Life Science
Panel : Physiology in Health, Disease and Ageing
Entité participante : Université technique de Munich — Pays : Allemagne — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2499999.0 €

Cardiac diseases are the leading cause of death worldwide, making human cardiac regeneration one of the most critical unmet clinical needs. The epicardium, the mesothelial envelope of the heart, is the source of several cardiac cells and provides signals that are essential for myocardial growth and vessel formation during development. Extensive animal research has indicated that the reactivation of these embryonic epicardial programs is the key to adult tissue repair in regenerative species such as the zebrafish, as well as in rodents up until a few days after birth, before the heart’s capacity for regeneration is lost. How the human epicardium develops and responds to injury is largely unknown. We recently established the first human pluripotent stem cell-based cardiac organoids showing the self-organization of epicardium and myocardium into a functionally patterned structure resembling the embryonic ventricular wall. These ‘epicardioids’ offer unique possibilities to study the dynamics of human epicardium development and function at a single-cell resolution. EPICURE aims at decoding and harnessing these programs as potentially transformative means for human heart regeneration. State-of-the-art lineage recordings, 3D imaging, and spatial multiomics in epicardioids will be used to dissect the fate acquisition mechanisms of the human embryonic epicardium and identify critical signalling pathways in health and disease. This in vitro approach will be complemented by charting a spatiotemporal, cross-species single-cell atlas of the cardiac injury response ex vivo and in vivo, including the first genetic lineage tracing of the adult epicardium in a large animal model. Finally, we will capitalize on the novel concept that CRISPR-mediated, temporal programming of the epicardium could drive meaningful heart regeneration in adulthood. Clearly, EPICURE will yield a wealth of new insights into human epicardial biology while breaking new ground in cardiac regenerative medicine.

Mots-clés : stem cells,organoids,transgenic large animals
Projet ERC : QFIELBS (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Fundamental Constituents of Matter
Entité participante : Conseil national de la recherche — Pays : Italie — Rôle : Partner
Acronyme de l'entité : CNR
Type d'entité : Recherche
Financement ERC de l'entité : 67185.0 €

Our understanding of the physical world, from cosmological distances to subatomic scales, is based on field theories, with General Relativity and the Standard Model among the most validated descriptions of reality. Despite their history of success, the application of field theories, particularly in the quantum domain, is still characterized by a rich set of open questions related to processes in- and out-of-equilibrium.  A paradigmatic example of a process in which field theories are successfully applied is that of first-order phase transitions. In this case, the dynamics of a system far from equilibrium cannot simply be described in terms of a perturbation of a steady state, but instead require combined tools and concepts taken from statistical and quantum mechanics. The transition results from the dynamics between field values associated with local minima of the system's energy. In the quantum regime, these local minima correspond to the so-called vacuum state of the field, making the problem well-defined but, surprisingly, exactly solvable in only a few simple cases.  Relaxation dynamics between different vacua, commonly known as False Vacuum Decay (FVD), is a case study that has significant impacts in broad and interdisciplinary research areas. Models have been proposed to estimate the decay rate, entanglement generation at the beginning of the decay, the dynamics of decay products, and the generation of topological defects at the end of the relaxation process. However, our knowledge to date is limited by a substantial lack of experimental observations.  This project aims to experimentally realize FVD and other challenging quantum field theories, both in the perturbative and in the non-perturbative regimes, such as confinement physics, using ultracold atomic spin mixtures through proper mapping of the atomic wave function into a quantum field representation and a unique set-up that ensures extremely stable magnetic field conditions.

Mots-clés : quantum simulation of field theories,out of equilibrium phenomena,quantum magnetism,coherently coupled atomic mixtures,analog models of gravity
Projet ERC : NODE (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Systems and Communication Engineering
Entité participante : Conseil national de la recherche — Pays : Italie — Rôle : PI
Acronyme de l'entité : CNR
Type d'entité : Recherche
Financement ERC de l'entité : 2499640.0 €

Artificial semiconductor heterostructures played a pivotal role in modern optoelectronic technologies, providing a highly effective platform for the generation of light across the mid-infrared (3-25um wavelengths) and Terahertz frequency ranges (50-250um). However, their challenging quantum engineering also limited their adoption in a spectral region (25-50um) still unexplored, and their use in frontier domains as integrated photonics and quantum science.  NODE aims to intersect two materials platforms that in the last decade widely progressed – artificial semiconductor heterostructures and bi-dimensional materials – to deliver a technological revolution in the whole far-infrared (FIR) (25-250um). By combining the potential offered by the lithographic engineering of quantum cascade lasers (QCLs) with the giant non-linearities of Dirac materials, NODE aims to develop compact and coherent, solid-state classical and not classical FIR sources, leading to an entirely new and disruptive platform of FIR instrumentation.  To reach these ambitious objectives, the versatile quantum design of QCLs will be exploited to engineer an ultrabroadband gain spectrum. By inserting graphene or topological insulators in the core QCL semiconductor heterostructure and implementing resonators of exotic fashion - elliptical tapered ring microcavities, sculptured wire lasers or gate-tunable plasmonic lasers - NODE will deliver the first: ps pulse, ring micro-resonator FIR comb, squeezed FIR laser, and electrically pumped source in the Reststrahlen band. A fast FIR technology to probe quantum correlation effects will be also devised.  Radically new concepts and interdisciplinary approaches, encompassing advanced materials and device engineering, non-linear and plasmonic phenomena, drive this ambitious project. Advancing the understanding of the complex non-linear dynamics in the devised systems, NODE prospects new directions and long-term impacts on fundamental, quantum and applied science.

Mots-clés : micro lasers,bi dimensional materials,far infared
Projet ERC : Si3 (Horizon Europe, appel 2023, Advanced grants)
Domaine scientifique : Life Science
Panel : Prevention,  Diagnosis and T reatment of Human Diseases
Entité participante : KTH Institut royal de technologie — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2851875.0 €

This project aims to design, construct, and evaluate a novel instrument for molecular imaging of radioactive nuclides in the human body. The hypothesis is that, by using next-generation silicon sensors to measure each photon interaction and applying kinematic constraints, the incident photon direction can be calculated. Thus, we can remove state-of-the-art mechanical collimators. The main objective of this project is to explore the physical limits of efficiency and spatial resolution and evaluate the concept for this new technology in medical imaging applications.  The new instrument should improve detector efficiency by about a factor of one million, reducing examination time from an hour to less than a second. The concept aims to overcome Compton cameras' shortcomings such as complicated geometries with low efficiency, that, despite several attempts, prevented this technique from going beyond an early prototype stage. The new sensor concept consists of a massive block of silicon built up from a multitude of sensors, with high resolution in space, energy and time and including signal shaping and data processing. The system will have orders of magnitude more read-out pixels than ever before in medical imaging. The system design and image reconstruction process are conceptually challenging, addressing several scientific problems at the component level such as pixel charge collection and capacitance, but also including image reconstruction from fragments of event circles, combinatorial problems involved with tracing each event to discern the correct order of interactions and to reject background events. Over a 10–20-year period, the technology could replace the current installed base, leading to significant impacts on adjacent research fields, such as drug development and targeted radionuclide therapy.

Mots-clés : molecular imaging,spect,single photon emission computed tomography,radiopharmaceuticals,targeted radionuclide therapy,compton camera,compton imaging,silicon sensors,photon counting,nuclear medicine,nuclear imaging
Projet ERC : BAMBBI (Horizon Europe, appel 2021, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Materials Engineering
Entité participante : Université polytechnique de Catalogne — Pays : Espagne — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2497334.0 €

Bacterial bone infections are one of the great challenges of orthopaedic and maxillofacial surgery, aggravated by antibiotic resistance, a serious health threat responsible for 700,000 deaths per year. The recent discovery of the bactericidal properties of some naturally occurring surface topographies has opened a new avenue of research. However, there is incomplete knowledge of the mechanisms of action and too many unanswered questions to translate these advances into clinical use. BAMBBI aims to tackle this challenge by developing synthetic bone grafts featuring contact-based antimicrobial properties, adding antimicrobial activity to their capacity to support bone regeneration. Using a novel bottom-up approach inspired in biomineralization routes, I intend to engineer the surface of calcium phosphates with an unprecedented and fine control of nanotopography by harnessing the power of ions and organic molecules (e.g. amino acids, calcium chelators and surfactants) to drive crystal nucleation and growth. Moreover, we will further enhance the antimicrobial effect by exploiting the synergy with chemical moieties to modulate bacterial affinity for the surface and/or confer additional antimicrobial properties by immobilisation of antimicrobial peptides. This will provide us with a platform to study the contact-based bactericidal mechanisms in depth and unravel the role of nanotopography and surface chemistry and their interplay with the intrinsic properties of bacteria. Only considering all these parameters will it be possible to unveil the causes of the substantial differences in bactericidal efficacy of a given substrate for different bacteria and design more efficient antibacterial surfaces. In addition to being a major breakthrough in the field of bone regeneration, the progress in new methods of fine-tuning the nanostructure of calcium phosphates will have an impact in very diverse fields such as catalysis, water purification and protein separation.

Mots-clés : antimicrobial materials,nanostructured materials,biomineralization,bone biomaterials
Projet ERC : DYNANOINT (Horizon Europe, appel 2023, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Physical and Analytical Chemical Sciences
Entité participante : Université de Jyväskylä — Pays : Finlande — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2499594.0 €

Metal nanoclusters (MNC) are atomically precise metal nanoparticles with definite mass, structure, and chemical composition. Their metal core of 1-3 nm in diameter exhibits quantized electronic structure, and they are chemically stabilized by a molecular surface layer which is modifiable for functionalization and optimized biocompatibility, making them promising materials for novel applications in bioimaging, biosensing and nanomedicine as fluorescent markers, sensors and targeting drug carriers, paving way to personalized medicine and therapeutics. Their ultrasmall size makes them amenable to atom-scale modeling which may greatly help experimental efforts to design their properties for applications. However, consolidated simulation strategies capable of dealing with phenomena over a wide range of dynamical processes at the nanocluster – biomolecule interfaces are missing. To address this need, DYNANOINT will develop new multiscale simulation strategies, assessing critically graph theory and machine learning (ML) methods as potential accelerators for discovery of structure-function relationships combined with traditional electronic structure methods and force-field based dynamical simulations. The methodology is applied to (i) weak chemical interactions between MNCs and proteins, (ii) electronic excitations and charge-transfer interactions at the MNC – environment interface, and (iii) chiral MNC – environment interfaces. PI’s extensive collaboration network to three key experiments around the world ensures efficient spread of impact of this theoretical-computational project to real-life applications. The project has a broad impact on computational nanoscience since the developed open-source software will give new tools to study structure-function relations in low-dimensional, low-symmetry nanostructures for which combination of robust, transferable, and interpretable ML models with traditional simulations methods poses a significant contemporary challenge.

Mots-clés : gold,silver,dna,nanocluster,protein,density functional theory,molecular dynamics,machine learning