Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : HIV ECLIPSE (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Life Science
Panel : Immunity, Infection and Immunotherapy
Entité participante : University of Edinburgh — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 529857.0 €

The HIV eclipse phase typically refers to the time between a virus entering a sexually exposed person and detection of viral RNA in their plasma. Of the four phases of HIV-1 infection (eclipse, acute, chronic and AIDS), the eclipse phase is currently the only window of opportunity for viral clearance. Systemic infection is currently irreversible after the onset of the acute phase. Preventing systemic HIV infection after exposure, therefore, requires understanding and targeting the eclipse phase. Information on this phase, however, is partial and indirect, with fundamental gaps in our knowledge of its role in limiting transmission, in determining the efficacy of infection control strategies, and in governing later infection. Mathematical modelling, when combined with statistical inference, is a useful tool for hypothesis testing and prediction using incomplete information. To date, however, there are no mathematical models that are particularly suitable because current models do not account for two important characteristics of eclipse phase infection. First, none of these models reconcile the very small per-exposure HIV-1 acquisition probability with the high estimate of the basic reproductive number, R0, during acute phase infection. Second, models of acute phase plasma viral load obscure early local dynamics of HIV when the virus forms local, heterogeneous clusters of infection in the genital mucosa before entering the lymphatic and blood systems. My research programme will develop novel models of HIV that are calibrated to diverse data sources to ascertain whether eclipse phase dynamics determine the acquisition of HIV and later infection dynamics. I will use phylogenetic analysis of HIV samples to quantify the role of the transmitting partner in determining viral inoculum dose size, eclipse phase dynamics and HIV acquisition. This research will generate testable predictions for exposed populations and aim to propose novel methods for infection prevention.
Projet ERC : FUSION (Horizon 2020, appel 2019, Consolidator grants)
Domaine scientifique : Life Science
Panel : Molecules of Life: Biological Mechanisms, Structures and Functions
Entité participante : University of London — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : U. London
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2280390.0 €

The HIV-1 vaccine research has re-emerged in the last few years due to the identification of antibodies that neutralize most HIV-1 circulating strains. A deeper understanding of the mechanistic mode of target recognition for these antibodies represents a big hope in the field. This project aims at understanding and characterizing polyclonal antibody responses to aid rational vaccine design via radically new technologies on light microscopy. The molecular mechanism of time-resolved HIV-1 fusion will be visualized and quantified on the surface of living cells by combining real-time single virus tracking, fluorescence fluctuation spectroscopy and 3D single molecule localization microscopy (SMLM) imaging. The implementation of a new technology that allows three-dimensional nanometre localization of single particles will allow us to multiplex single molecule experiments with functional readouts for single-virus HIV-1 fusion simultaneously. Here, I will systematically establish the mechanism of action of different families of neutralizing antibodies and how they disrupt the three-step HIV fusion reaction, conserved among different HIV tropism, recently discovered by our group. I will unveil the molecular insights on the precise Env-induced, time-resolved stoichiometry of CD4 and co-receptors (CCR5 or CXCR4) in the presence and absence of different combinations of bNAbs and study their impact on HIV transmission. FUSION will open new avenues to design putative drugs that target host-specific receptor and co-receptor oligomeric states to block HIV-1 fusion. This project systematically applies cutting-edge time-resolved imaging approaches as a gold standard to ascertain how different combinations of bNAbs perturb the HIV fusion mechanism in CD4+ T cells and macrophages. I will establish a world-class laboratory in HIV-1 and single molecule microscopy. I will decipher several key virus–host cell interactions at molecular level and contribute to rational vaccine and drug desig

Mots-clés : single molecule fluorescence,number and brightness,single virus tracking,super resolution light microscopy,hiv 1 fusion,membrane fusion mechanism,broadly neutralizing antibodies,live cell imaging
Projet ERC : HYPNOTIC (Horizon 2020, appel 2016, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Systems and communication engineering
Entité participante : Université Paris Cité — Pays : France — Rôle : Partner
Acronyme de l'entité : UP Cité
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 299846.13 €

The HYPNOTIC project aims at achieving a breakthrough in Silicon laser science and technology by taking forward the III-V semiconductors on Silicon hybrid technology into the nanophotonic world to make the dream of the convergence of microelectronics and photonics on a chip come true. This project intends to take up the challenge of bringing to reality electrically powered photonic crystal nanolasers as reference sources for dense integration and logical processing in a Silicon-based optical platform by accomplishing: (i) power efficiency with extremely low activation energies of few fJ, (ii) high bandwidth beyond 40Gbits/s, (iii) compactness with footprints less than 100µm² for high integration density of 103-104 of devices per mm2. A paradigm change will be brought to Silicon photonics by laying down 3 corner stones which consist firstly in the realisation of ultimate nanolaser diode sources at telecom wavelengths using an optimised single hybrid active nanocavity. Secondly, the groundbreaking atomic physics concepts of superradiance and lasing without inversion of population resonators will be transposed to nanophotonics by coupling several active nanocavities. Besides studying them for their fundamental interest, the project will capitalise on them to drastically augment the power efficiency and the modulation bandwidth of the nanosources. Finally, the fabricated nanolaser diodes using these novel concepts will be exploited to demonstrate cutting-edge flip-flop and memory devices able to surpass current off-chip electronic random access memories in access times and bandwidth which could enable unprecedented computational power.
Projet ERC : HYPNOTIC (Horizon 2020, appel 2016, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Systems and communication engineering
Entité participante : Centre national de la recherche scientifique — Pays : France — Rôle : PI
Acronyme de l'entité : CNRS
Type d'entité : Recherche
Financement ERC de l'entité : 1681874.87 €

The HYPNOTIC project aims at achieving a breakthrough in Silicon laser science and technology by taking forward the III-V semiconductors on Silicon hybrid technology into the nanophotonic world to make the dream of the convergence of microelectronics and photonics on a chip come true. This project intends to take up the challenge of bringing to reality electrically powered photonic crystal nanolasers as reference sources for dense integration and logical processing in a Silicon-based optical platform by accomplishing: (i) power efficiency with extremely low activation energies of few fJ, (ii) high bandwidth beyond 40Gbits/s, (iii) compactness with footprints less than 100µm² for high integration density of 103-104 of devices per mm2. A paradigm change will be brought to Silicon photonics by laying down 3 corner stones which consist firstly in the realisation of ultimate nanolaser diode sources at telecom wavelengths using an optimised single hybrid active nanocavity. Secondly, the groundbreaking atomic physics concepts of superradiance and lasing without inversion of population resonators will be transposed to nanophotonics by coupling several active nanocavities. Besides studying them for their fundamental interest, the project will capitalise on them to drastically augment the power efficiency and the modulation bandwidth of the nanosources. Finally, the fabricated nanolaser diodes using these novel concepts will be exploited to demonstrate cutting-edge flip-flop and memory devices able to surpass current off-chip electronic random access memories in access times and bandwidth which could enable unprecedented computational power.
Projet ERC : Hi-OMICS (Horizon 2020, appel 2017, Proof of concept grants)
Entité participante : Barcelona Supercomputing Center — Pays : Espagne — Rôle : PI
Acronyme de l'entité : BSC
Type d'entité : Recherche
Financement ERC de l'entité : 149375.0 €

The Hi-OMICS PoC aims to pave the road to commercialisation of the Hi-OMICS Controller, a Software Defined Infrastructure Controller (SDI) specifically designed to efficiently manage Computational Genomics workloads running on upcoming SDI platforms. The necessary activities to achieve this status are structured in two blocks: 1) Market analysis, Commercialisation Plan and the definition and implementation of a IPR protection plan for the Hi-OMICS Controller; and 2) Software development efforts to bring Hi-OMICS Controller to a Commercial Readiness Level 6. The PoC will build on top of the research conducted within the Hi-EST project (ERC Starting Grant, GA 639595). It will close the gap between the research results of the Hi-EST Starting grant and the production of a commercial software solution (Hi-OMICS Controller) for the Computational Genomics sector. In particular, the solution will target facilities running Computational Genomics pipelines for genomic or transcriptomic sequences derived mostly, but not only, from Next Generation Sequencing. The result of this effort will be the achievement of a market-ready Hi-OMICS Controller.

Mots-clés : software defined infrastructures,computational genomics,process optimisation,software acceleration,disaggregated computing
Projet ERC : CUBE (Horizon 2020, appel 2019, Synergy grants)
Entité participante : University of Turin — Pays : Italie — Rôle : PI
Acronyme de l'entité : UNITO
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2079791.0 €

The Holy Grail of selective C-H activation has been vigorously pursued for more than 70 years in all areas of catalysis - homogeneous, heterogeneous and biological - yet with scarce cross-fertilization. CUBE will bridge this gap, by synergistically disclosing the secrets of Cu-containing biological and synthetic catalysts and translating the acquired knowledge into rationally designed new catalysts with unprecedented activity, selectivity and turn-over numbers. CUBE will capitalize on the recent discovery of abundant and experimentally accessible natural enzymes (LPMOs) that activate resilient C-H bonds using a mono-Cu catalytic center, thus providing a biological analogue to synthetic Cu-zeolites. CUBE will also harness the potential of metal-organic frameworks (MOFs), which offer unprecedented (“enzyme-like”) flexibility in catalyst development. C-H activating Cu-containing Zr-MOFs have just been described. CUBE will generate trans-disciplinary insights into Cu-based catalysts to progress beyond the state of the art in C-H activation. To this aim, we will elucidate the key mechanistic features of oxidant activation by O2, as well as N2O and H2O2, and then C-H activation. Emerging design principles from these studies will evolve new catalysts, including engineered enzymes, enzyme-polymer hybrid materials, and MOFs. To enable these efforts, we will develop novel methodologies at the interface of spectroscopy and computational chemistry. The project brings together leading players in complementary fields: design, synthesis and testing of catalysts (UiO), enzymology and protein engineering (NMBU), spectroscopic investigations of heterogeneous catalysts (UoT) and spectroscopic/computational studies of homogeneous and biological catalysts (MPI). Through a work-plan conceived to maximize cross-fertilization within the project team, we will design and develop novel catalysts for tomorrow’s C-H activation chemistry.

Mots-clés : protein engineering,chemical biology,bioinspired catalysts,c h activation,direct methane conversion,bio catalysis,enzymatic catalysis,pmmo,lpmo,cu zeolites,cu zr metal organic frameworks
Projet ERC : CUBE (Horizon 2020, appel 2019, Synergy grants)
Entité participante : Max Planck Society — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : MPG
Type d'entité : Recherche
Financement ERC de l'entité : 2103750.0 €

The Holy Grail of selective C-H activation has been vigorously pursued for more than 70 years in all areas of catalysis - homogeneous, heterogeneous and biological - yet with scarce cross-fertilization. CUBE will bridge this gap, by synergistically disclosing the secrets of Cu-containing biological and synthetic catalysts and translating the acquired knowledge into rationally designed new catalysts with unprecedented activity, selectivity and turn-over numbers. CUBE will capitalize on the recent discovery of abundant and experimentally accessible natural enzymes (LPMOs) that activate resilient C-H bonds using a mono-Cu catalytic center, thus providing a biological analogue to synthetic Cu-zeolites. CUBE will also harness the potential of metal-organic frameworks (MOFs), which offer unprecedented (“enzyme-like”) flexibility in catalyst development. C-H activating Cu-containing Zr-MOFs have just been described. CUBE will generate trans-disciplinary insights into Cu-based catalysts to progress beyond the state of the art in C-H activation. To this aim, we will elucidate the key mechanistic features of oxidant activation by O2, as well as N2O and H2O2, and then C-H activation. Emerging design principles from these studies will evolve new catalysts, including engineered enzymes, enzyme-polymer hybrid materials, and MOFs. To enable these efforts, we will develop novel methodologies at the interface of spectroscopy and computational chemistry. The project brings together leading players in complementary fields: design, synthesis and testing of catalysts (UiO), enzymology and protein engineering (NMBU), spectroscopic investigations of heterogeneous catalysts (UoT) and spectroscopic/computational studies of homogeneous and biological catalysts (MPI). Through a work-plan conceived to maximize cross-fertilization within the project team, we will design and develop novel catalysts for tomorrow’s C-H activation chemistry.

Mots-clés : protein engineering,chemical biology,bioinspired catalysts,c h activation,direct methane conversion,bio catalysis,enzymatic catalysis,pmmo,lpmo,cu zeolites,cu zr metal organic frameworks
Projet ERC : CUBE (Horizon 2020, appel 2019, Synergy grants)
Entité participante : University of Oslo — Pays : Norvège — Rôle : CO-PI
Acronyme de l'entité : UiO
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2906039.0 €

The Holy Grail of selective C-H activation has been vigorously pursued for more than 70 years in all areas of catalysis - homogeneous, heterogeneous and biological - yet with scarce cross-fertilization. CUBE will bridge this gap, by synergistically disclosing the secrets of Cu-containing biological and synthetic catalysts and translating the acquired knowledge into rationally designed new catalysts with unprecedented activity, selectivity and turn-over numbers. CUBE will capitalize on the recent discovery of abundant and experimentally accessible natural enzymes (LPMOs) that activate resilient C-H bonds using a mono-Cu catalytic center, thus providing a biological analogue to synthetic Cu-zeolites. CUBE will also harness the potential of metal-organic frameworks (MOFs), which offer unprecedented (“enzyme-like”) flexibility in catalyst development. C-H activating Cu-containing Zr-MOFs have just been described. CUBE will generate trans-disciplinary insights into Cu-based catalysts to progress beyond the state of the art in C-H activation. To this aim, we will elucidate the key mechanistic features of oxidant activation by O2, as well as N2O and H2O2, and then C-H activation. Emerging design principles from these studies will evolve new catalysts, including engineered enzymes, enzyme-polymer hybrid materials, and MOFs. To enable these efforts, we will develop novel methodologies at the interface of spectroscopy and computational chemistry. The project brings together leading players in complementary fields: design, synthesis and testing of catalysts (UiO), enzymology and protein engineering (NMBU), spectroscopic investigations of heterogeneous catalysts (UoT) and spectroscopic/computational studies of homogeneous and biological catalysts (MPI). Through a work-plan conceived to maximize cross-fertilization within the project team, we will design and develop novel catalysts for tomorrow’s C-H activation chemistry.

Mots-clés : protein engineering,chemical biology,bioinspired catalysts,c h activation,direct methane conversion,bio catalysis,enzymatic catalysis,pmmo,lpmo,cu zeolites,cu zr metal organic frameworks
Projet ERC : INSOLENSYS (Horizon 2020, appel 2020, Proof of concept grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : Universidade Nova de Lisboa — Pays : Portugal — Rôle : PI
Acronyme de l'entité : NOVA
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 120000.0 €

The INSOLENSYS technology is proposing a game-changing concept for solar energy management. It introduces, for the first time ever, an integrated approach to the generation and storage within PV cells which compensates the main drawback of current approaches, i.e. the need to manage the intermittency of solar energy through costly and polluting external storage systems. INSOLENSYS will deliver a flexible solution that can be adapted to all the types of solar cells, be it home system or large-scale industrial installations for the around-the-clock generation of stable energy, fully eliminating the need on external storage. The here proposed technology is poised to significantly contribute to the goals of the EU in terms of the Green Deal policy not only because it facilitates the widest wide-spread of the renewable energy, but also because it is based on eco-friendly and available raw materials. The scopes of the present PoC is to: prove the viability of the INSOLENSYS approach on a pre-industrial scale through extensive testing and validation; and explore the commercial potential of the technology while increasing its Technology and Investment Readiness Levels. The work will be performed by the PI’s team in partnership with the Venture Building company D1 which will take care of the business development and marketing strategy development, including the introduction to VC and CVC companies.

Mots-clés : capacitor,thermoeletric  solar cells,integration,self charge device
Projet ERC : INTER (Horizon 2020, appel 2016, Proof of concept grants)
Entité participante : Politecnico di Milano — Pays : Italie — Rôle : PI
Acronyme de l'entité : POLIMI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 149375.0 €

The INTER project aims at the design and production of a proof of concept demonstrator component essential for the development of a novel, tunable and portable neutron source. Neutron beam-based analysis (neutron diffraction, neutron activation analysis, active interrogation) and imaging (radiography, tomography) methods are a powerful tool for non-destructive testing (NDT) of materials and find numerous important applications in industry, security, and material science and technology. Use of laser-driven ion accelerators to generate neutrons can potentially overcome the limitations of conventional neutrons sources. Within the ERC-CoG ENSURE project, I developed a nanostructured material, used to produce a novel multi-layer target concept] allowing to enhance the laser-ion production efficiency with reduced laser requirements and, at the same time, robust enough to be adopted in a commercial targetry device, paving the way for operation with relatively low-energy, commercial, high rep-rate laser systems (1J; 1-10TW; 10-100 Hz). Upon approval of the present INTER ERC-PoC project, I will provide an accelerator module demonstrator, based on such novel target concept, for the generation of an innovative, portable neutron source. If successful, INTER will open the way to put on the market a ready-to-use compact accelerator module able to generate ion & neutron beams with a transportable, affordable laser system. Availability of this technology would find important applications of strong economical and societal interest, like checking for drugs and explosives concealed in luggage and cargo containers, in-situ analysis of key industrial (e.g. engine turbines blades) and electronic (e.g. to measure impurities in silicon semiconductors) components, imaging/interrogation of nuclear fuels, explosives, cultural heritage artifacts, as well as in biology, medicine, fuel cell research and geoscience.

Mots-clés : neutron,laser,laser plasma interaction,material science,nanostructured materials
Projet ERC : IONOSENSE-POC (Horizon 2020, appel 2014, Proof of concept grants)
Entité participante : Institut Mines-Télécom — Pays : France — Rôle : Partner
Acronyme de l'entité : IMT
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 21918.0 €

The IONOSENSE-POC project proposes a novel solution to enable label-free, electronic monitoring of live cells in vitro, using innovative organic bioelectronic technology. The device, the organic electrochemical transistor (OECT), integrated with live cells forming a tissue, has been shown to accurately assess the integrity of the cells, providing dynamic, highly sensitive measurements after exposure to toxins/pathogens. Validation against traditional, optical methods, or commercially available electronic monitoring equipment demonstrated the OECT to have equal or improved sensitivity and temporal resolution. As an added bonus, the OECT is fabricated using conducting polymers, which are not only amenable to low cost processing techniques, but are also optically transparent, yielding devices compatible with high resolution imaging techniques, of critical importance to life scientists. In the POC project, we propose to take this extremely promising technological breakthrough developed in an academic environment, and transition it to a prototype suitable for future commercialization. In parallel, the appropriate steps will be taken necessary to ascertain the market niche(s), initially identified as being in the areas of Biomems targeted for diagnostics/drug discovery. Finally, an adapted exploitation strategy will be developed to best suit the technology developed during the IONOSENSE project. The team assembled to execute the project is extremely committed to the commercialization venture, in particular due to significant feedback from industrial partners (potential endusers) from such diverse biomedical applications as the cosmetics industry, neurotoxicology, electrophysiology instrumentation developers, drug development companies etc. The success of this POC project will have broad ranging, highly positive impacts for society in the EU and further, due to reduction of experimentation on animals, improved healthcare outcomes, and economic development to name a few.

Mots-clés : in vitro diagnostics,conducting polymers,toxicology,high throughput,organic bioelectronics,organic electrochemical transistor,electrophysiology,high resolution imaging,low cost,biosensors