Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : PACE (Horizon 2020, appel 2019, Proof of concept grants)
Domaine scientifique : Life Science
Panel : Prevention, Diagnosis and Treatment of Human Diseases
Entité participante : Amsterdam University Medical Centers — Pays : Pays-Bas — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 150000.0 €

The problem: Ageing and age-related diseases cause degeneration of the cardiac conduction system (CCS) that creates and conducts the electrical impulse which drives the heart beat (pacing). The resulting slow heart rate (bradycardia) necessitates electronic pacemaker implantation in 500,000 patients yearly in Europe (direct costs of €3.4 billion). This current state-of-the-art treatment has significant limitations (dangerous complications, reduced quality-of-life) that, stemming from its design, may never be resolved. Regeneration of CCS function is conceptually superior and scientific discoveries, enabling CCS regeneration, were recently made. Closest to clinical testing are a variety of gene therapy-based strategies that can provide for biological pacing. Complementary strategies to repair conduction are also under development. The solution: To transit biological pacemaker therapies towards clinical testing it will be crucially important to optimize the gene delivery vectors with transcriptional targeting to the CCS. This will provide for more efficient and safer vectors that can be utilized in the context of biological pacing and repair of compromised conduction. The PACE project is designed to provide for final proof-of-concept in the development path, moving forward from scientific discovery towards clinical implementation and testing. As such the PACE project will optimize and validate the use of CCS-specific cis-acting regulatory modules (CRMs) to optimize transcriptional targeting to desired CCS components in the heart and validate these in vivo. The development and validation of these CCS-targeted vectors will importantly strengthen our IP-position, thereby supporting the business development efforts that are an integral part of the PACE project.

Mots-clés : gene therapy,biological pacing,transcriptional targeting,cis acting regulatory modules
Projet ERC : METRO (Horizon 2020, appel 2016, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Social World and Its Diversity
Entité participante : University of Edinburgh — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1199805.0 €

The production of global metrics by International Organisations has not only penetrated the transnational social and policy fields; it has also become an integral mode of the ways International Organisations interconnect. Through their collaborative practices of quantification and commensuration, International Organisations are both constituting new realities and being reconstituted themselves. Thus, the dominance of global measurement regimes has profound implications for the ways International Organisations interact, and for the environments these new interrelationships come to generate. How is one to make sense of this emerging reality? The embryonic –but rapidly deepening– alliances between International Organisations to find global solutions to global crises, is an opportune moment for a two-fold enquiry: a. an in-depth investigation of the labour of the joint production of metrics; and b. an examination of the ways this labour reconfigures interdependencies between International Organisations and hence the field of transnational governance itself. This is a novel, problem-driven perspective that goes beyond the role and impact of International Organisations through ‘governing by numbers’: instead, we bring together multiple bodies of knowledge in order to cast light on the role metrics play in re-shaping the data collectors themselves. Hence, focusing on the policy areas of Education and Development, this is an interdisciplinary study of the ways International Organisations co-exist, compete and survive in an increasingly quantified yet uncertain world. Building on International Relations theory, Science and Technology Studies, and using theoretical perspectives from Organisational Sociology, as well as the newly emerging field of the social studies of metrics, this research will apply a mixed-methods research design to examine the interrelationships of International Organisations in co-constructing the global metrological field.

Mots-clés : quantification,metrics,measurement,indicators,numbers,interdisciplinarity,sociology,mixed methods,statistics,international organisations,education,sustainable development
Projet ERC : IDEAL SENSOR (Horizon 2020, appel 2016, Proof of concept grants)
Entité participante : Polytechnic University of Turin — Pays : Italie — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 147500.0 €

The project IDEAL SENSOR is developing a wearable wrist band device and a customized structural health monitoring (SHM) system for managing emergencies. The proposed system provides a comprehensive solution for indoor localization, healthcare monitoring, and other general purpose services (fitness, entertainment, health, etc.). Moreover, an infrastructure based on the structural health monitoring will be developed which include all the functionality of standard Structural Health Monitoring (SHM) systems (environmental monitoring, health assessment, etc.), but it performs also indoor localization. In detail, the system is composed of different environmental monitoring sensors (humidity and temperature), body signal monitoring (heart rate, body temperature, humidity, location and images), communication modules (radio frequency (RF) transceiver, GPRS/GSM, GPS and Bluetooth low energy), OLED display. Currently , the prototype has been developed and tested in a STM Nucleo-F401 board which is a developing board provided by STMicroelectronics commonly used for rapid prototyping. In order to commercialize the prototype and make it a feasible product, the current developed system should be redesigned and customized based on our needs and requirements. The electrical parts will be redesigned completely and the best available solutions (price and quality) for each sub-module and components will be used. Moreover, by miniaturizing the prototype and designing a user friendly package and software, it will get the shape of a real smart watch with more features with respect to the current ones.

Mots-clés : pe8 3 civil engineering,maritime,hydraulic engineering,geotechnics,waste treatment
Projet ERC : DYNAPORE (Horizon 2020, appel 2015, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Synthetic Chemistry and Materials
Entité participante : University of Liverpool — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2493425.0 €

The project addresses the long-term vision of man-made materials with chemical selectivity and functional efficiency produced by dynamic structural flexibility. These materials are not intended as protein mimics; they are however inspired by nature’s use of flexible rather than rigid systems, with their ability to dynamically restructure around guests and thus perform highly specific chemistry. Such materials would transform chemical processes through their precision, for example by reorganising to accelerate each step of a cascade reaction without reagent or product inhibition. The road to this vision is blocked as we do not have the methodology and understanding to control such materials. The aim is to develop synergic, multidisciplinary experimental and computational capability to harness the dynamics of flexible crystalline porous solids for function, demonstrated in separation and catalysis. This will enable design and synthesis of materials that controllably adopt distinct structures according to their chemical environment to optimise performance. We will create a new workflow that integrates understanding of the structure-composition-dynamics-property relationship into the materials design and discovery process. This workflow builds on proof-of-concept in (i) chemical control of dynamical restructuring in flexible crystalline porous materials and in the use of dynamics to (ii) enhance function and (iii) guide synthesis. Crystalline flexible porous materials are selected because crystallinity maximises the atomic-scale understanding generated, which is transferable to other materials classes, whilst porosity permits sorption and organisation of guests that controls function. This inorganic materials chemistry project develops integrated capability in chemical synthesis (new metal-organic frameworks and linkers), computation (prediction and evaluation of structure and dynamical guest response), characterisation (e.g. by diffraction) and measurement of function.
Projet ERC : OurMythicalChildhood (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : Bar-Ilan University — Pays : Israël — Rôle : Partner
Acronyme de l'entité : BIU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 115500.0 €

The project aims at developing a pioneering approach to the reception of Classical Antiquity in children’s and young adults’ contemporary culture. This newly identified research field offers valuable insights into the processes leading to the formation of the culture recipients’ identities along with their initiation into adulthood. However, the most vital potential of this phenomenon remains unexploited, for the research is still selective, focused mainly on Western culture. With my project, I intend to overcome these limitations by applying regional perspectives without the pejorative implication of regional as parochial or inferior. I recognize regions as extremely valuable contexts of the reception of Antiquity, which is not only passively taken in, but also actively reshaped in children’s and young adults’ culture in response to regional and global challenges. Thus, the essence of this innovative approach consists in comparative studies of differing reception models not only across Europe but also America, Australia & New Zealand and – a bold but necessary step – in parts of the world not commonly associated with Graeco-Roman tradition: Africa and Asia. The shared heritage of Classical Antiquity, recently enhanced by the global influence of popular culture (movies, Internet activities, computer games inspired by the classical tradition), gives a unique opportunity – through the reception filter – to gain deeper understanding of the key social, political and cultural transformations underway at various locations. The added value of this original research, carried out by an international team of scholars, will be its extremely broad impact on the frontiers of scholarship, education and culture: we will elaborate a supra-regional survey of classical references, publish a number of analyses of crucial reception cases, and prepare materials on how to use ancient myths in work with disabled children, thus contributing to integration and stimulating cultural exchange.

Mots-clés : classics,classical reception studies,children s literature,children s culture,young adults  literature,young adults  culture,classical mythology,ancient greece,ancient rome
Projet ERC : OurMythicalChildhood (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : Université de Yaoundé I — Pays : Cameroun — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 41500.0 €

The project aims at developing a pioneering approach to the reception of Classical Antiquity in children’s and young adults’ contemporary culture. This newly identified research field offers valuable insights into the processes leading to the formation of the culture recipients’ identities along with their initiation into adulthood. However, the most vital potential of this phenomenon remains unexploited, for the research is still selective, focused mainly on Western culture. With my project, I intend to overcome these limitations by applying regional perspectives without the pejorative implication of regional as parochial or inferior. I recognize regions as extremely valuable contexts of the reception of Antiquity, which is not only passively taken in, but also actively reshaped in children’s and young adults’ culture in response to regional and global challenges. Thus, the essence of this innovative approach consists in comparative studies of differing reception models not only across Europe but also America, Australia & New Zealand and – a bold but necessary step – in parts of the world not commonly associated with Graeco-Roman tradition: Africa and Asia. The shared heritage of Classical Antiquity, recently enhanced by the global influence of popular culture (movies, Internet activities, computer games inspired by the classical tradition), gives a unique opportunity – through the reception filter – to gain deeper understanding of the key social, political and cultural transformations underway at various locations. The added value of this original research, carried out by an international team of scholars, will be its extremely broad impact on the frontiers of scholarship, education and culture: we will elaborate a supra-regional survey of classical references, publish a number of analyses of crucial reception cases, and prepare materials on how to use ancient myths in work with disabled children, thus contributing to integration and stimulating cultural exchange.

Mots-clés : classics,classical reception studies,children s literature,children s culture,young adults  literature,young adults  culture,classical mythology,ancient greece,ancient rome
Projet ERC : 2-NanoSi (Horizon 2020, appel 2014, Proof of concept grants)
Entité participante : Fundacio institut d'investigació i innovació parc tauli — Pays : Espagne — Rôle : Partner
Acronyme de l'entité : I3pt - cerca
Type d'entité : Autres
Financement ERC de l'entité : 12531.25 €

The project aims to create a demo system for cost effective, non-invasive device for rapid detection of cystic fibrosis in humans. The detection of human recessive diseases has been dominated by the use of fluorescent biomarkers, based on organic dyes, helping researchers to study and analyse gene expression, cell cycle, and enzymatic activity. Among several proteolytic enzymes, trypsin has attracted much attention, as it is a target in the study of various important human recessive diseases including, for example, cystic fibrosis (CF). We present herein two colour encoded silica nanospheres (2nanoSi) for the fluorescence quantitative ratiometric determination of cystic in humans. Current detection technologies for cystic fibrosis diagnosis are slow, costly and suffer from false positives. The 2nanoSi proved to be a fast (minutes), a single-step and with two times higher sensitivity than the state-of-the-art biomarkers based sensors for cystic fibrosis, allowing the quantification of trypsin concentrations in a wide range (25-350 μg/L). Moreover, our approach can be used from the 4th day of life when the trypsin concentration is already the same as in adults. Furthermore, as trypsin is directly related to the development of cystic fibrosis (CF), different human phenotypes, i.e. normal (160-340 μg/L), CF homozygotic (0-90 μg/L), and CF heterozygotic (91-349 μg/L), respectively, can be determined using our 2nanoSi nanospheres. We anticipate the 2nanoSi system to be a starting point for non-invasive, easy-to-use and cost effective ratiometric fluorescence biomarker for recessive genetic diseases alike human cystic fibrosis.

Mots-clés : nanomedicine,health,nanomaterials,cistic fibrosis
Projet ERC : POP-R (Horizon 2020, appel 2016, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Human Mind and Its Complexity
Entité participante : Centre national de la recherche scientifique — Pays : France — Rôle : PI
Acronyme de l'entité : CNRS
Type d'entité : Recherche
Financement ERC de l'entité : 2498485.0 €

The project centers on a new computational model, the POP-R model, that implements two original, and apparently contradictory, hypotheses with respect to the processing of orthographic information spanning several words during silent reading for meaning: 1) orthographic information spanning several words is processed in parallel and integrated within a single pool of location-invariant orthographic representations; 2) readers process multiple word identities in parallel and keep track of the positions of these words by associating word identities with spatiotopic locations in short-term memory. The apparent contradiction is solved in POP-R by the triangular connectivity between gaze-centered letter detectors, spatiotopic word identities, and location-invariant orthographic representations. Evidence in favor of the first hypothesis has been obtained with a novel Flanking Letters Lexical Decision task. The second hypothesis predicted the existence of a sentence superiority effect in a novel Rapid Parallel Visual Presentation paradigm, for which we have preliminary evidence. Other key predictions of the POP-R model will be tested in behavioral experiments using these new techniques, and EEG and MEG recordings will be used to specify the spatio-temporal dynamics of the neural processes underlying orthographic pooling and parallel word identification. Experiments with primary school children will plot the developmental trajectory of these processes, and sentence reading experiments measuring eye-movements and ERPs will be used to further test the model. The project incorporates both theoretical and methodological innovation within a novel perspective on reading that places orthographic processing at the very heart of the reading network. This new perspective is expected to facilitate the integration of knowledge concerning low-level visual processing and eye-movement control with higher-level semantic and syntactic processing during silent reading for meaning.

Mots-clés : reading,orthographic processing,computational modeling
Projet ERC : TIMEJ (Horizon 2020, appel 2016, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Zurich — Pays : Suisse — Rôle : PI
Acronyme de l'entité : UZH
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2497500.0 €

The project explores time in medieval Japan, taking a new approach to historical articulations of the concept of time, based on the theory of symbolic forms. It will examine symbolic representations and social regulations of time in a civilisation that is often juxtaposed to contemporary, globalised modernity. We will investigate into medieval Japan as a dynamic and internally differentiated society, and not as a unified “traditional” culture dominated by a qualitative concept of time. We will focus on its plural ways of registering, measuring, articulating, and regulating time. The aim is to disclose the specific cultural practices operative in the respective ways of negotiating time, and to achieve a more comprehensive and detailed account of human strategies in dealing with this fundamental restriction of our existence. In a closely coordinated set of case studies, we examine representative spheres connected to various symbolic forms and socio-cultural agendas: the Zen monastery, the female court, and the market. An intersectional case study explores the symbolic mediations of the menstrual cycle, connecting these spheres and uniting aspects of the physical, ritual and symbolic regulation of human body time. Each case study explores the symbolic forms prevalent in the respective settings, and the aspects of time that are deemed relevant and selected for symbolic articulation. We will analyse temporal encoding, structure and application in the regulation of affairs, the competence to account and regulate these processes, and the influence on feelings of dismay in the face of the socio-cultural realities of time. Special attention is paid to the conflicts that arise when established regimes of temporal regulation and expression clash with each other and with individual experience. The results will be compared to the history of time in the Western world, and integrated into a theory of the symbolic forms of time.

Mots-clés : time,symbolic forms,concepts of time,time regimes,japanese buddhism,zen buddhism,court literature,gender,diaries,menstrual cycle,market
Projet ERC : PanEur1970s (Horizon 2020, appel 2014, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : European University Institute — Pays : Italie — Rôle : PI
Acronyme de l'entité : EUI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1811200.0 €

The project investigates the European Socialist regimes’ expectations and predicaments vis-à-vis the opening of a space of pan-European cooperation in the long 1970s. Against the background of East-West détente and incipient globalization, the Socialist élites had to work out complex ideological, economic, and political issues originating from their attempts at integrating in the world economy, deepening their rapprochement with Western Europe and dealing with the commercial giant next door, the EC. We intend to provide the first historical appraisal of the late Socialist élites’ views of their countries’ place and prospects in an emerging space of trans-European connections that presented them with new patterns of exchange and potential regional integration while challenging existing configurations of stability, political control and ideological self-legitimization. The project intertwines international and economic history approaches to provide a dynamic portrait of the Socialist élites’ paradigms, goals and constraints in envisioning interdependence with Western Europe and cooperation with the EC. In order to map the debate within each European socialist country, our focus will be not only on the ruling party but also on state bureaucracy, experts and academics, trade unions, managers, and the official press. Our research will thus rely on a variety of primary sources originated by these actors. Our study aims at linking the usually separate scholarships on Eastern and Western Europe and broadening the scope of integration historiography beyond the EC experience, bringing the outsiders’ perspective in. It will shed new light on the long-term paths of European integration and the antecedents to EU enlargement to Eastern Europe. The PI will lead a team of experts on Socialist countries and historians of Western Europe’s integration, whose close collaboration is the key to the conceptual development of a broader history of European co-operation.

Mots-clés : european integration,east west relations