Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : SeRO (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Human Mobility, Environment, and Space
Entité participante : Université de Stockholm — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1637905.0 €

Violent crime affects countries on all continents, with known negative impacts on victims and society. Recent research highlights that even nearby violence, without direct victimization, can affect people’s well-being. Sexual and reproductive health is a fundamental aspect of human well-being with profound importance for individuals, families, and societies. Yet, how local violent crime affects sexual and reproductive health remains poorly understood.  The SeRO project provides the first systematic account of the consequences of local violent crime on sexual and reproductive health. SeRO focuses on Mexico, which is an ideal case study due to its recent dramatic surge and strong variation in violent crime, highly stratified sexual and reproductive health, and uniquely rich data resources. The project builds on an innovative mixed-methods research design, combining nationally representative surveys, administrative records, clinic data, and in-depth interviews.  SeRO will: (1) Investigate how exposure to local violent crime affects sexual and reproductive health (2) Identify mechanisms mediating the impact of local violent crime on health (3) Analyze variations across intersecting social groups (4) Examine how society responds to violent crime regarding sexual and reproductive health  Personal safety and sexual and reproductive health are key indicators of development, quality of life, and basic freedoms. SeRO breaks new ground in an emerging interdisciplinary field focused on the social, demographic, and health consequences of violence and crises. This research advances knowledge about local violence as a social determinant of health, analyzing how individuals are affected by complex social contexts, navigate their life courses, and respond to societal pressures and opportunities. The SeRO project will provide recommendations for future intervention research and evidence-based policies to address the health costs of violent crime, with relevance for diverse settings.

Mots-clés : sexual and reproductive health,gender based violence,gender norms,violent crime
Projet ERC : PARA-MOR (Horizon Europe, appel 2023, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Human Mobility, Environment, and Space
Entité participante : Université de Stockholm — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1498870.0 €

If the global foreign-born population all lived in single country, it would be the fifth largest country in the world. The rapid rise and diversification of contemporary worldwide migration has no precedent in history. There is clear evidence that immigrants are healthier than native-born populations are. Although this health advantage is pervasive for mortality (i.e., death), it is regularly absent, or even reversed, for morbidity (i.e., diseases and medical conditions). This is alarming because it suggests that migrants are living long lives in poor overall health. With immigrants’ ageing in place, this should constitute one of the most highly relevant social and public health concerns today. Yet, beyond evidence from disparate data sources of variable quality and coverage, there is a distinct absence of direct, coherent, empirical knowledge of this morbidity-mortality paradox.  To address this gap, I aim to establish the existence, extent, and causes of this immigrant morbidity-mortality paradox. I will use cutting-edge techniques to analyse longitudinal micro-level data on morbidity and mortality from the same source of information: the population registers of Denmark, Finland, Norway and Sweden.  Work Package A will reveal how prevalent an immigrant morbidity-mortality paradox is within the Nordic region and evaluate the role that this paradox plays in our understanding of wider population health. Work Package B will identify the intricate disease spectrum, causes-of-death, and granular immigrant origins essential to understanding the paradox. Work Package C will identify the mechanisms that can explain the paradox. This research has the potential to (1) transform the limited way in which the health of immigrants is currently conceptualised and understood, (2) revolutionise how researchers analyse immigrant health, (3) highlight immigrant health and its role in wider population health, and (4) directly inform national and international policy.

Mots-clés : international migration,population health,morbidity,mortality,demography,epidemiology,public health,advanced quantitative methods
Projet ERC : INFLUX (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Human Mobility, Environment, and Space
Entité participante : Université de Stockholm — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1295440.77 €

Emerging pests and pathogens (EPPs) are an increasingly disruptive force to human society that can cause large social and ecological changes far beyond their initial site of emergence. Three forces contribute to this growing challenge now and in the foreseeable future: first, potential EPPs are more likely to come in to first contact with human habitats as human land use expands. Second, denser human trade and travel networks mean that EPPs are more likely to emerge in new regions. Third, human technology, such as biocidal agents, increases risks for re-emergence. Understanding how EPPs cascade across scales in social-ecological systems is therefore an urgent priority, but no formal approach currently exists for analysing the ripple effects at scale, from their seeding to their lasting societal imprints. This project aims to fill this gap in sustainability science for society.  The INFLUX project will test the hypothesis that EPPs commonly cascade to interact with large-scale social and environmental challenges and that small differences in social-ecological conditions in turn influence the likelihood and nature of EPP cascades. I will test this hypothesis by leveraging a comparative, mixed-methods research design to assemble a large database for up to 1600 EPPs, encompassing microbial pathogens as well as arthropod and plant pests. Specifically, four objectives will be pursued, which are to understand:  1. The drivers of emergence risk and their connections to human environmental sustainability and social conditions. 2. The types of cascades that result from action aimed at governing EPPs. 3. The lasting impacts EPPs have on societies and the conditions under which they arise. 4. The feedbacks from 3.-1. including through implications for social equity and environmental sustainability.  INFLUX constitutes a major step in situating EPPs in the field of sustainability science, and for developing societal capacity to navigate a future characterized by them

Mots-clés : emerging pests and pathogens,social ecological systems,cascading cross scale dynamics,anthropocene
Projet ERC : METABALANCANCER (Horizon Europe, appel 2023, Starting grants)
Domaine scientifique : Life Science
Panel : Prevention,  Diagnosis and T reatment of Human Diseases
Entité participante : Université de Milan — Pays : Italie — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 755120.0 €

The goal of this proposal is to explore combinations of targeted metabolite supplementation and global nutrient restriction as a new strategy to reprogram tumor metabolism, to halt tumor progression and to improve response to treatments. Preclinical and clinical studies published by our group and by others showed that global nutrient restriction, in the form of cyclic fasting or fasting-mimicking diets (FMDs), produces desirable metabolic and immunologic effects that result in reduced tumor progression and in the prolongation of animal/patient survival. Of note, our unpublished results indicate that the supplementation of specific amino acids or fatty acids has in vitro and in vivo antitumor effects, which are strongly enhanced when metabolite supplementation is combined with nutrient starvation. By employing canonical cell biology and biochemical experiments, polysome/ribosome profiling, isotope tracing experiments and integrated omics (transcriptomic, proteomic, metabolomic) analyses in in vitro and in vivo murine and human tumor models, here we propose to: - identify the cell-autonomous and immune-mediated mechanisms at the basis of the antitumor effects of targeted metabolite supplementation in combination with global nutrient restriction; - identify the most effective metabolite supplementation-restriction strategy to be tested in a first-in-human clinical trial in patients with advanced triple-negative breast cancer. While the basic cancer research and medical oncology communities are engaged in a historical scientific and clinical diatribe on the use of nutrient deprivation vs. supplementation approaches to halt tumor progression and to improve patient survival, we will exploit our unprecedented ability to conduct parallel preclinical and clinical experimentation in the field of cancer metabolism to identify new and effective combinations of balanced metabolite supplementation and restriction, with relevant scientific and translational implications.

Mots-clés : in vitro models in vivo models anticancer immunity multi omics bioinfomatics
Projet ERC : BREAKDOWN (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and Processes Engineering
Entité participante : Université d'Udine — Pays : Italie — Rôle : PI
Acronyme de l'entité : UniUd
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499954.0 €

It appears paradoxical how today's frontier & high-impact research seeks for designing new materials to delay structural failures – especially fatigue – while the same effort is not seen concerning the way materials can be efficiently and safely used in real structural applications. BREAKDOWN aims to transform engineering products’ design methods by identifying and including a set of (sub)micro-scale material inhomogeneities characteristics in a novel probabilistic framework. The time has come to exploit modern experimental techniques to probe material properties at a small scale, which are scarcely involved in current fatigue characterisation schemes. To attain this very ambitious goal, the project will rely on a breakdown of different classes of inhomogeneities to advance the fundamental mechanical understanding of their contribution to fatigue, and then reunite them within an advanced Bayesian Physics-Guided Neural Network (B-PGNN) frame. Over the past three years, I assiduously worked to prove the feasibility of BREAKDOWN and demonstrate its superior capabilities. However, I have merely scratched the surface of what is potentially achievable with this approach, both in terms of knowledge advancement and real engineering applications. An extensive multimodal experimental characterisation campaign will be conducted on different material inhomogeneity states to separate and identify their individual influence on fatigue in a systematic and detailed way. Cutting-edge numerical & analytical models will be developed and exploited as the physics knowledge in the B-PGNN scheme to effectively tackle the small datasets issue when dealing with fatigue and to ensure soundness of results. The outstanding capabilities of the framework developed in BREAKDOWN will be confirmed through specific demonstrators. BREAKDOWN will excellently contribute towards the development of a much more sustainable design procedure with unprecedented social, economic and environmental benefits.

Mots-clés : fatigue,probabilistic,physics informed,machine learning,defects,residual stress,micromechanics,additive manufacturing,material processing,structural reliability,computational mechanics
Projet ERC : OptoQuantTOP (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed Matter Physics
Entité participante : Université de Bâle — Pays : Suisse — Rôle : PI
Acronyme de l'entité : UniBasel
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2364733.0 €

A central goal in modern condensed matter physics is to understand and manipulate collective phenomena at the intersection of topology and strong many-body interactions. Moire materials composed of layered van der Waals (vdW) crystals are a unique platform for exploring this frontier. These systems support flat topological electronic bands resembling Landau levels but without magnetic fields. This has recently enabled realization of long-sought fractional Chern insulators (FCIs): zero-field analogs of fractional quantum Hall (FQH) states. Unlike the latter, FCIs operate in an unexplored regime where electrons spontaneously break time-reversal symmetry and experience emergent magnetic fields far exceeding those in standard laboratories. This raises timely fundamental questions: What is the nature of collective fractionally charged excitations of FCIs? Can they couple to light? Can we engineer vdW devices that allow for in-situ programming of FCI properties with light, a feat impossible for FQH? Addressing these questions could have revolutionary implications, unlocking dynamical access to the phase diagrams of topologically-ordered phases, a key challenge in the field.  The overarching goal of this project is to develop an optical interface that enables local, on-demand, ultra-fast access and control over strongly correlated topological phases in moire materials. Using this platform, we will answer key questions of topological many-body physics, with potential groundbreaking technological applications in topotronics and quantum computing.

Mots-clés : two dimensional materials van der waals heterostructures optical spectroscopy topological phases of matter chern number fractional chern insulators strongly correlated electrons quantum sensing anyonic excitations optical spin orientation fractional quantum hall effect
Projet ERC : InfoFate (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Life Science
Panel : Cell Biology, Development, Stem Cells and R egeneration
Entité participante : Université de Bâle — Pays : Suisse — Rôle : PI
Acronyme de l'entité : UniBasel
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1498051.0 €

Embryonic development relies on the ability of multi-cellular systems to collectively coordinate the establishment of precise spatial patterns of cell fates. An inevitable obstacle to such coordination is intrinsic noise at the single-cell level, which constrains the amount of information accessible to cells for fate decisions. While such information was often considered to be encoded in overall concentrations of extracellular signals, it is becoming increasingly clear that cells use a much broader set of inputs to make decisions. In this project, we will develop a new data-driven theoretical framework of developmental patterning to quantify, characterize and predict how cells generate and process four types of information: dynamical signals, neighborhood interactions, tissue heterogeneity, and mechanical information. We will establish a novel theoretical methodology by uniting computational tissue models that account for single-cell noise with information theory to bridge the scales and relate mechano-chemical inputs to cell fate decisions. We will develop this approach in direct connection with spatio-temporal imaging experiments in two model systems. First, we will determine how regulatory interactions in 2D human gastruloids generate information encoded in complex signaling dynamics, and how single cells can use this information to decide their fate. Second, we will reveal how signaling and mechanics interplay to establish mechano-chemical information in intestinal organoids, driving simultaneous fate patterning and tissue morphogenesis. This project will uncover how cell-cell interactions establish self-organized spatial patterns that relay information accessible to single cells to reliably instruct cell fate decisions, and give insight into the fundamental constraints under which developmental systems operate.

Mots-clés : information theory
Projet ERC : EnhanceRegen (Horizon Europe, appel 2022, Starting grants)
Domaine scientifique : Life Science
Panel : Cell Biology, Development, Stem Cells and R egeneration
Entité participante : Institut Karolinska — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1500000.0 €

The mammalian central nervous system (CNS) is the epitome of complex cellular architecture. Still, it has a limited capacity to self-repair after an injury, which contrasts with the regenerative potential of the CNS in lower vertebrates. Regeneration unfolds by the orchestrated triggering of developmental gene expression programs after injury. These programs are under the control of dedicated regeneration enhancer elements, which grant adult cells transcriptional access to developmental genes. Neural stem cells in the mammalian CNS lack the gene regulatory circuits that dictate when and where to activate the expression of developmental genes for regeneration. Consequently, most of the cells lost to injury are never replaced. This proposal aims to rewire mammalian gene expression circuits to endow neural stem cells with the capacity to activate regenerative responses after injury. First, building on innovative technologies, some of which that I developed, we will identify injury-responsive enhancer elements in the mouse spinal cord with single cell and spatiotemporal resolution. Then, using machine learning, we will decode the rules of injury-sensing DNA elements to design synthetic injury-responsive enhancers for precise gene expression control in neural stem cells. Finally, we will use synthetic enhancers in therapeutically relevant gene delivery systems to rewire gene circuits in order to promote the recruitment resident stem cells for cell replacement through the reactivation of developmental genes that would otherwise remain silent. The proposed research will uncover basic principles of gene regulation after CNS injury and open new avenues for the design of smart gene therapies for regenerative medicine using synthetic regeneration enhancers.

Mots-clés : spinal cord mouse single cell genomics atac seq machine learning enhancers gene therapy reprogramming
Projet ERC : MARCEN (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Université de Turku — Pays : Finlande — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1498109.0 €

Globally, indigenous peoples’ rights appear to become recognised to a greater extent, but are indigenous groups more included in settler states’ laws and societies? Built on the strong foundation of legal mobilisation, rights development and transitional justice theories, MARCEN aims to inaugurate a paradigm-shifting legal inclusion theory with broad implementation possibilities.  With the goal of establishing a new scientific foundation to understand the interplay between supranational and national legal frameworks, governance practices, and the socio-legal position of indigenous groups, the first contours of this legal inclusion theory will be outlined using the most prominent indigenous group in Europe – the Sámi in the Nordic countries (Sweden, Norway and Finland) as a comparative case study. With the Sámi under scrutiny, MARCEN will address:  1) How supranational and national legal regulation and rights developments affect the governance of indigeneity; 2) The historical (1920s–2020s) perspective of indigeneity framing and governance; 3) The impetuses, scopes, and effects of indigenous truth and reconciliation commissions; 4) How indigenous groups have used law and global rights discourses to mobilise, voice claims and improve their position.  Using an innovative methodology, MARCEN is uniquely positioned to bridge the interdisciplinary gaps in the interplay between international and national laws, policies, legal cultures, theory and practice.  The legal inclusion theory will be the starting point of a prominent research field, with extensive applicability within and beyond indigenous rights. As such, the findings of the project extend to the fields of integration, migration, marginalisation, inequality and discrimination. Building on my 10-year track record covering socio-legal scholarship, MARCEN will give me the opportunity to enable the urgently needed shift towards greater understanding of legal inclusion and exclusion.

Mots-clés : legal inclusion and exclusion,indigenous peoples,rights development,transitional justice,comparative law,socio legal studies,legal mobilisation
Projet ERC : COPE (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Study of the Human Past
Entité participante : Université de Vienne — Pays : Autriche — Rôle : PI
Acronyme de l'entité : Uni Wien
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1653690.0 €

Climate change, and thus environmental change, is one of the major challenges of all life forms. This was particularly the case in the Late Pleistocene (129,000–11,700 years ago), when the amplitude, frequency and severity of climate change was intense, making environmental conditions unpredictable and unprecedented. Animals respond differently to these challenges – affecting adaptability, ecological tolerance and behaviour. In the history of our species in Europe, these challenges became most pronounced in the period leading up to the Last Glacial Maximum (LGM). Yet, very few prehistoric sites preserve records that span the whole period or preserve organic remains, thus limiting our understanding of how local human groups responded and survived. One exception is Grub-Kranawetberg, a site that not only preserves rich archaeological strata that span the entire onset of the LGM, but also has exceptional organic preservation, including a rich floral record. COPE aims at applying a range of techniques that bridge traditional archaeology and cutting-edge archaeological science to explore the lithic, faunal, floral and hydrological records from this extraordinary site, and throw light on human behavioural resilience to climate change. COPE uses recent advances in sedimentary biomarkers, oxygen isotope and aDNA analyses to gain a novel, comprehensive view of both past local environmental conditions and environmentally-driven adaptive responses in the exploitation of a mosaic of resources. Gained insights will, in turn, be used to re-evaluate regional archaeological records that lack organic preservation. Ultimately, by investigating what strategies ancient populations employed that maximised inert and living resources in the face of extreme climate change, COPE offers a highly original perspective to environmentally-driven adaptation and human resilience in deep time.

Mots-clés : palaeolithic archaeology,raw material procurement strategies,zooarchaeology,landscape use,late gravettian