Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : e-Perinatal (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Life Science
Panel : Prevention,  Diagnosis and T reatment of Human Diseases
Entité participante : Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla — Pays : Espagne — Rôle : Partner
Acronyme de l'entité : FISEVI
Type d'entité : Recherche
Financement ERC de l'entité : 0.0 €

Maternal mental disorders are the most common complications during pregnancy and within the first year after childbirth (defined as the perinatal period) and are the leading cause of maternal suicide. Affected mothers cannot function properly, causing a devastating impact on the entire family. Effective primary prevention interventions are urgently needed. However, the current scientific evidence is insufficient to implementing primary preventive programs at the population level.  I aim to establish the effectiveness of universal preventive interventions for maternal perinatal mental disorders and to support their implementation as normalized routine practice in global healthcare services. Integrating classical and emerging methodological frameworks (family systems, self-determination theory, and normalization process theory), as well as the perspective of patient and public involvement in research, I will: (a) Develop a personalized mobile-Health preventive intervention for mothers and their partners, which integrates evidence-based psychological components and personalized health recommendations; (b) Test preventive intervention effectiveness for reducing the incidence of maternal depression and anxiety disorder, reducing father/partner symptoms of depression and anxiety, and promoting child health and development; (c) Apply a causal methodology, to pinpoint the underlying mechanisms for the effectiveness of the preventive intervention; and (d) Understand the implementation process and identify the factors that can promote or inhibit implementation.  With the multidisciplinary team that I lead – and a large-scale hybrid effectiveness-implementation trail in real-world maternal health services – this research programme promises to be the first in its field. The resulting robust scientific evidence and novel explanatory model will create a new research paradigm. A toolkit for implementation research will enhance translation as normalized routine practice.

Mots-clés : prevention perinatal mental disorders postpartum depression women primary health care
Projet ERC : OLIGOMERS (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Life Science
Panel : Molecules of Life: B iological  Mechanisms , Structures  and Functions
Entité participante : Institut Weizmann — Pays : Israël — Rôle : PI
Acronyme de l'entité : WIS
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1500000.0 €

Ion channels are transmembrane proteins regulating ion flux across cell membranes and are crucial for numerous physiological processes. Hence, ion channels are implicated in many diseases. To further drug development targeting ion channels, a comprehensive understanding is needed not only of their low-energy abundant states, but also of their rare and transient high-energy states, which play critical roles in channel function, regulation, and folding. The cutting-edge high-speed atomic force microscopy (HS-AFM) technique allows now to study such states, by providing simultaneously, on a single-molecule level, both dynamic and structural information of freely diffusing ion channels in the membrane, a feat that is currently impossible with other methods. Recently, I discovered using HS-AFM that the TRPV3 channel possesses a rare and transient pentameric state that reversibly interconverts with its canonical tetrameric sate, potentially conferring it new function. Here, I aim to investigate further the functional role and biological relevance of this finding, while concomitantly investigating if similar oligomeric plasticity occurs in other ion channels of diverse functions. Most particularly, I aim to investigate whether reversible oligomeric changes could be an additional mechanism for ion channels to modulate function. To do so, I will: 1) Discover reversible oligomeric transitions in other ion channels. 2) Reveal how reversible oligomeric transitions could modulate function. 3) Assess the physiological relevance and feasibility of such transitions. Positive results will lead to a paradigm shift in the way we think about the assembly, dynamics, and function of ion channels and introduce a novel new concept of how ion channels undergo conformational changes. Additionally, results will be of high impact to translational applications such as drug development and drug delivery and establish HS-AFM as a powerful complementary method in the field of structural biology.

Mots-clés : ion channels,oligomeric state,cryo em,hs afm,rare and transient states
Projet ERC : SELECT (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Systems and Communication Engineering
Entité participante : Université d'Édimbourg — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1486463.0 €

Nature, through millennia of evolution, has endowed living organisms with unmatched sensory adaptability. As robotics weave more deeply into the fabric of human society, a compelling challenge emerges: mimicking the sensory intelligence intrinsic to these life forms. The intricate synergy between the organism’s skin and brain, delivering unrivalled sensory insight and data interpretation, epitomises a domain in robotics still uncharted. Cultivating such perceptive sense in robots is crucial; it heralds a future with enhanced safety and adaptability in human-robot interactions, revealing new horizons for innovative applications.  SELECT aims to bridge this perception gap in soft robotics – a rapidly evolving robotic field inspired by the softness of living beings. At the heart of SELECT lies the ambition to pioneer smart electronic skins (e-skins) that resonate with the sensory capability of organisms. SELECT's objectives include:  1. Develop multi-modal e-skins for holistic perception. 2. Build models to simulate the integration of e-skins and robots. 3. Explore automated, adaptive e-skin designs. 4. Advance learning algorithms to decode e-skin data. 5. Streamline e-skin deployment and training.  SELECT's outcomes promise to redefine soft robot perception, synergising e-skin sensory attributes with state-of-the-art machine learning. Beyond advancing robotics, SELECT envisions reshaping our interaction dynamics with intelligent systems, championing a new epoch of human-machine symbiosis.

Mots-clés : soft robotics,perception
Projet ERC : AmpBoot (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Fundamental Constituents of Matter
Entité participante : Université d'Édimbourg — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499484.0 €

The Standard Model of particle physics represents one of the major achievements of modern science, and with the discovery of the Higgs boson at the Large Hadron Collider its predictions have been tested to unprecedented levels of precision. These measurements will continue to improve as more data is collected in the coming years, allowing us to probe the fundamental laws of physics to an unparalleled degree. However, to benefit from these measurements, the precision with which we can make theoretical predictions in quantum field theory must also be drastically improved. This in particular requires improving our understanding of scattering amplitudes, which provide essential input for these calculations.  While scattering amplitudes are notoriously difficult to compute, they have been found to exhibit an immensely rich mathematical structure, with deep ties to number theory, algebraic geometry, and string theory. These connections have recently fueled a revolution in our ability to compute highly nontrivial amplitudes in supersymmetric theories to unprecedented levels of precision. Building on this progress, I propose three lines of investigation for developing the same level of insight into the mathematical structure of Standard Model amplitudes, and for bypassing the difficult integration problems that have traditionally been required for their evaluation:  1) the derivation of new constraints on the analytic structure of amplitudes from basic physical requirements such as causality and locality  2) an in-depth study of the types of special functions that appear in amplitudes and the development of new tools for working with them  3) the development of perturbative bootstrap methods for Standard Model amplitudes  These lines of research will give rise to deep new insights into the universal properties of perturbative quantum field theory, and facilitate the development of groundbreaking new methods for making precision predictions for collider experiments.
Projet ERC : EuroSoHo (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Human Mobility, Environment, and Space
Entité participante : Université de Szczecin — Pays : Pologne — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1473000.0 €

European riverine and coastal floodplains are highly managed systems, where different human actions can both increase or decrease flood risk. For instance, the “levee effect” could reduce the effectiveness of structural flood protection by encouraging exposure growth and lack of individual precaution, increasing impacts when a severe flood eventually overwhelms the dikes. On the other hand, frequent flooding has been shown to reduce vulnerability through adoption of local precautionary measures (“adaptation effect”). Current European projections of future flood risk under climate change do not consider these types of effects and other dynamic interactions in floodplains. Though such feedbacks could be captured by socio-hydrological models, those have been so far limited to small case studies due to lack of data. The aim of this project is to develop a European Socio-Hydrological Model (EuroSoHo) to quantify past and future flood risk dynamics across the continent. This probabilistic, system dynamics model will be calibrated on historical (1950–2025) data on flood occurrence, their impacts (fatalities, population affected, economic loss), floodplain exposure changes, and large-scale flood prevention schemes across more than 1400 regions in 42 European countries. The model will incorporate multiple socio-hydrological parameters (e.g. awareness, preparedness, reactiveness or risk aversion), quantifying the historical baseline of the society’s reaction to floods. EuroSoHo will then be able to project the future evolution (2026–2100) of the human-water system in Europe under the expected changes of both hydroclimatic and socioeconomic forcing. The system-wide positive and negative effects of improving dikes, extending individual preparedness, restrictions on exposure growth, and relocation will be quantified with EuroSoHo. The results will indicate which combination of adaptation strategies would be most effective in each region given their local-scale costs and benefits

Mots-clés : flood risk socio hydrology risk management climatic change
Projet ERC : MAtCHLESS (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Physical and Analytical Chemical Sciences
Entité participante : Université Ca' Foscari de Venise — Pays : Italie — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1450000.0 €

Cellular organisms are complex machines whose health and functioning are dictated by parameters including temperature, oxygen concentration, and pH. Luminescence nanosensing is a technology that promises all the features required to reliably monitor these parameters at the intracellular level: minimal invasiveness, remote working principle, and submicrometric spatial resolution. These features are ensured by the use of sub-micrometric sensors (particles) whose luminescence is sensitive to changes in the parameters to be sensed. Yet, despite the hype about luminescence nanosensing, its reliability in the study of cells is limited by interparticle variability in optical properties and sensing performance, simultaneous response to several parameters (cross-sensitivity), and lack of a measurement technology that enables fast 2D mapping of multiple parameters with sub-second temporal resolution. MAtCHLESS tackles heads on these limitations to develop a reliable luminescence sensing technology for multiparameteric sensing in cell studies. This project entails: design of a novel family of composite submicrometric luminescent sensors, elimination of interparticle fluctuations in optical properties using a spectral sorting strategy, introduction of the paradigm shift of making cross-sensitivity a desirable feature via machine learning, and use of a novel optical technology to build a setup for 2D mapping of multiple parameters with high temporal and spatial resolution. MAtCHLESS will test the reliability of the sensing approach in mammalian cell lines and extremophiles – microorganisms that can withstand extreme conditions of, e.g., temperature, oxygen concentration, and pH. These investigations will show the potential of the developed technology to monitor both slight and extreme changes in biological parameters, towards a deeper understanding of, e.g., how cancer can be more effectively treated, as well as how Life evolved on Earth and can be adapted beyond our planet.

Mots-clés : luminescence sensing,submicroparticles,machine learning,intracellular
Projet ERC : P-AGE (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Université Ca' Foscari de Venise — Pays : Italie — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499049.0 €

The commonly accepted reason for the right to punish is the defence of society, or social defence. However, its meaning in Western criminal justice remains unclear. In an increasingly punitive age, punishments have become harsher, irrespective of the seriousness of the crime. It is therefore necessary to scrutinise the episteme behind punishment. In fact, despite its profound impact on individuals’ lives, the penal system lacks an adequate normative foundation because social defence functions as an implicit paradigm without a clear elaboration. P-AGE’s objective is to analyse the long-term discourse on social defence and its current transnational relevance, with the ultimate goal of understanding how and why punishment came to be perceived as an adequate response to various societal issues. More specifically, P-AGE sheds light on the criminological legal debate on the concept of social defence, a debate that has been largely overlooked in scholarly literature. Social defence was first theorised at the turn of the 20th century within the underexplored field of Positivist Criminology. This concept has persisted until today, due to the post-WWII emergence of the New Social Defence (NSD) movement, an association of criminal law reformers who worked in concert with the United Nations Social Defence Research Institute (UNSDRI), now called the United Nations Interregional Crime and Justice Research Institute (UNICRI), in shaping current crime policy programmes. P-AGE investigates this historical setting and development in order to understand what social defence means and to make the implicit paradigm of the punitive age explicit. P-AGE’s methodology employs the epistemic community model to identify and analyse the transnational network of actors and ideas that substantiate social defence. The project blends critical criminology, intellectual legal history, and policy analysis to rewrite the history of punitive reason by foregrounding the key concept of social defence.

Mots-clés : criminal justice intellectual legal history critical criminology policy analysis
Projet ERC : aCCuracy (Horizon Europe, appel 2022, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Physical and Analytical Chemical Sciences
Entité participante : Université polytechnique et économique de Budapest — Pays : Hongrie — Rôle : PI
Acronyme de l'entité : BME
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1175215.0 €

We propose comprehensive theoretical method development targeting a long-standing dilemma in molecular quantum simulations between controllable predictive power and affordable computational time. While the outstanding reliability of quantum chemistry’s gold standard model is repeatedly corroborated against experiments, its traditional form is limited to the size of an amino acid molecule. By exploiting the short-range nature of leading interaction contributions, a handful of groups, including ours, have recently extended the reach of such quantitative energy computations up to a few hundred atoms. However, these state-of-the-art models are still too demanding and are not at all equipped to compute experimentally relevant dynamic, spectroscopic, and thermodynamic molecular properties.  Thus, to break down these barriers, we will further accelerate our cutting-edge gold standard methods up to few 1000 atoms via concerted theoretical and algorithmic developments, and high-performance software design. Additionally, we will take into account biochemical, crystal, and solvent environment effects via cost-efficient embedding models. For the first time, we will also derive and implement practical approaches to compute static and dynamic observable properties for large molecules at the gold standard level. The exceptional capabilities of the new methods will enable us to study challenging chemical processes of practical importance which are not accessible with chemical accuracy for any current lower-cost alternative. We aim at modeling and understanding intricate covalent- and non-covalent interactions governing supramolecular and protein-ligand binding as well as the mechanism of organo-, organometallic, surface, and enzyme catalytic reactions.  Once successful, this project we will deliver groundbreaking and open access tools for the systematically improvable and predictive quantum simulation of large molecules in realistic conditions and environments.

Mots-clés : quantum chemistry wave function theory,quantum chemical method development,algorithm design in quantum chemistry,coupled cluster theory many body perturbation theory electron correlation calculation high precision quantum chemical simulations computational modeling of reactions and molecular interactions
Projet ERC : EpidemioCene (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Life Science
Panel : Environmental B iology, Ecology  and E volution
Entité participante : Société Max-Planck pour le développement des sciences — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : Société Max Planck
Type d'entité : Recherche
Financement ERC de l'entité : 872500.0 €

The frequency of infectious disease emergence has increased over the last decades, a phenomenon attributed to modern global sociodemographic and environmental changes. However, major transformations of human lifestyles and technologies associated with large-scale repercussions on the planet's ecosystems have occurred since prehistory. Measuring the epidemiological impacts of these changes on large time scales could provide precious lessons to anticipate the consequences of ongoing processes. Recent advances in the field of paleogenetics have opened promising perspectives in this regard by allowing the identification of various pathogens from skeletal remains dating back several millennia. The use of ancient DNA evidence for quantitative assessments of past disease distribution and determinants has, however, largely been missing so far. With this project, my group will leverage tens of thousands of ancient DNA libraries and sequencing datasets produced during recent years at the host and partner institutions to undertake large-scale paleoepidemiological investigations covering the past 12,000 years of human history in western Eurasia. Novel laboratory, bioinformatic and statistical approaches will be developed to maximize pathogen detection sensitivity and estimate variations in disease frequency from ancient metagenomic data while accounting for expected sources of biases. This will be combined with epidemiological modelling and phylodynamic analyses of large sets of ancient pathogen genomes to unveil paleoepidemiological dynamics and their associations with sociocultural transitions and environmental changes throughout the Holocene. This project will provide unprecedented insights into the inseparable history of humans and their pathogens, a multi-millennial perspective on current global health challenges, and strong foundations for future paleoepidemiological studies.
Projet ERC : CAGED (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Soci al World and Its Interactions
Entité participante : Société Max-Planck pour le développement des sciences — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : Société Max Planck
Type d'entité : Recherche
Financement ERC de l'entité : 710000.0 €

The worldwide increase in the number of individuals that are ageing behind bars sparks heightened concerns about the extent to which carceral environments can foster the foundational conditions for ageing individuals to lead meaningful lives. However, the underdevelopment of research on carceral ageing is one of the most significant contemporary challenges in the social scientific study of criminal behaviour and society’s response to it. Scholarship is particularly lagging behind in Europe. The CAGED project addresses this critical need by understanding how existential psychosocial changes induced by human ageing intersect with effects of incarceration. It is designed to bridge two distinct academic realms: gerontology, which encompasses the multidisciplinary study of ageing, and penology, which is the study of punishment and incarceration. The project will push disciplinary boundaries, both methodologically and theoretically, by applying an interactive mixed-methods and interdisciplinary approach that is guided by three objectives: First, it will delve into the existential dimensions woven into the narratives of incarcerated ageing individuals, by employing multi and novel interviewing methods. Secondly, the project will develop a novel instrument for measuring existential meaning among diverse regimes and groups of ageing individuals. The measurement will encompass all carceral environments in Belgium. Renowned for its diverse approaches to the integration and segregation of older individuals in carceral settings, it makes an excellent case study with broad relevance across European jurisdictions. The measuring study will also extend to an age-segregated facility for older adults in Germany, unique in Europe. In bringing these insights together, the project will finally culminate in a ground-breaking interdisciplinary theoretical framework. In its pursuit, CAGED will propel the field of carceral ageing studies forward and launch a new field of geronto-penology.

Mots-clés : ageing,incarceration,existential dimensions,meaning,mixed methods,interdisciplinary