Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : NGBMI (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Human Mind and Its Complexity
Entité participante : University of Tübingen — Pays : Allemagne — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

Today, five out of ten diseases worldwide resulting in long-term disability are related to the central nervous system. Due to the immense complexity and inter-individual variability of the human mind and brain there are still no effective and side effect free treatment options for many serious neuropsychiatric disorders, such as major depression, dementia or schizophrenia. Recent advancements in sensor technology and computational capacities resulted in the development of brain/neural-machine interfaces (B/NMIs) that translate electric, magnetic or metabolic brain activity into control signals of external devices, robots or machines. Moreover, novel transcranial magnetic and electric brain stimulation (TMS/TES) systems were developed allowing for direct modulation of brain activity. However, current B/NMIs are limited by the low information extraction rate constraining fluent direct brain-machine interaction. Furthermore, as simultaneous assessment of brain oscillations during TES was regarded unfeasible due to stimulation artefacts, current TES systems can only deliver “open-loop” stimulation unrelated to the underlying dynamic brain states resulting in highly variable TES effects. Building on the applicant’s previous work that includes pioneering work on in vivo assessment of brain oscillations during TES (Soekadar et al. 2013, Nature Communications) and full restoration of daily living activities after quadriplegia using a novel B/NMI hand exoskeleton (Soekadar et al. 2016, Science Robotics), the NGBMI project will overcome these limitations by merging both techniques. After developing the first real-time B/NMI-TES system allowing for effective modulation of brain functions and fluent direct brain-machine interaction, the system will be tested in persons with impaired brain function (e.g. depression, dementia or stroke). Finally, the B/NMI-TES paradigm will be implemented in a wireless and wearable EEG-based system that can be used in everyday life environments.

Mots-clés : closed loop transcranial electric stimulation  tes,neural substrates of the human mind,everyday life brain,neural machine interfaces
Projet ERC : ADDITIVES (Horizon 2020, appel 2019, Consolidator grants)
Domaine scientifique : Life Science
Panel : Prevention, Diagnosis and Treatment of Human Diseases
Entité participante : Institut national de recherche pour l'agriculture, l'alimentation et l'environnement — Pays : France — Rôle : Partner
Acronyme de l'entité : Inrae
Type d'entité : Recherche
Financement ERC de l'entité : 81875.0 €

Today, our daily diet typically contains dozens of food additives (e.g. colours, emulsifiers, sweeteners: ~350 substances allowed on the EU market). Safety assessment is performed by health agencies to protect consumers against potential adverse effects of each additive, yet such an assessment is only based on current available evidence, i.e., for most additives, only in-vitro/in-vivo toxicological studies and exposure simulations. Meanwhile, the long-term health impact of additives intake and any potential ‘cocktail’ effects remain largely unknown and have become a source of serious concern. Growing evidence link the consumption of ultra-processed foods, containing numerous additives, to adverse health outcomes, in particular our recent results on cancer (Fiolet BMJ 2018). While most additives allowed in the EU are likely to be neutral for health and some may even be beneficial, recent animal and cell-based studies have suggested detrimental effects of several such compounds. In humans, data is lacking. No epidemiological study has ever assessed individual-level exposure to a wide range of food additives and its association with health, hampered by unsuited traditional dietary assessment tools facing the high additive content variability across commercial brands. Hence, a major breakthrough will come from the novel and unique tools I developed with my team, notably within the NutriNet-Santé cohort (n=164,000), collecting precise and repeated data on foods and beverages usually consumed, including names and brands of industrial products. With this unique resource, I propose a project at the forefront of international research to provide answers to a question of major importance for public health. Built as a combination of epidemiological studies and in-vitro/in-vivo experiments, this project will shed light on individual exposure to food additive 'cocktails' in relation to obesity, cancer, cardiovascular diseases and mortality, while depicting underlying mechanisms.
Projet ERC : NARMESH (Horizon 2020, appel 2016, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : Ghent University — Pays : Belgique — Rôle : PI
Acronyme de l'entité : UGent
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1130000.0 €

Today’s ecological crisis prompts us to rethink our attitude towards physical and natural realities that have traditionally been seen as opposed to human subjectivity and agency. What emerges from this “non-human turn” is a sense of our interdependence on things like the bacteria in our intestines or the carbon atoms supporting life on Earth. Ecological theorist Timothy Morton uses the metaphor of the “mesh” to express this idea of human/non-human interconnectedness. This project will map the formal and thematic strategies through which contemporary narrative practices engage with the non-human and envisage this interconnectedness. Storytelling is an indispensable tool for making sense of experience by establishing temporal and causal relations. But it is also biased towards the human-scale realities of action and social interaction. How can narrative overcome this bias? How does it convey phenomena that challenge our belief in the ontological and material self-sufficiency of the human? Comparing fictional narratives in print (novels and short stories) and conversational storytelling, we will systematically explore the ways in which narrative can forge connections across levels of reality, weaving together the human and the non-human into a single plot. The assumption is that narrative is a field where fictional practices are in constant dialogue with the stories told in everyday conversation—and with the culture-wide beliefs and concerns those stories reflect. Through its three sub-projects, the proposed research charts this complex dialogue while greatly advancing our understanding of how stories can be used to heighten people’s awareness of the mesh and its significance. The project builds on a combination of methods (close readings of novels, qualitative analysis of interviews), aiming to open up a new field of study at the intersection of literary scholarship and the social sciences—with narrative theory serving as a catalyst for the interdisciplinary exchange.

Mots-clés : narrative theory,narratology,the novel,science and literature,ecocriticism,narrative methods in the social sciences,qualitative research,anthropocene,ecological crisis,interconnectedness
Projet ERC : QUANTOM (Horizon 2020, appel 2020, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : University of Eastern Finland — Pays : Finlande — Rôle : PI
Acronyme de l'entité : UEF
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2000000.0 €

Tomographic images are a valuable tool in various applications of medicine and biomedicine, industry and in security applications. Although efficient tomographic imaging techniques exist, development of new modalities that would overcome the limitations of the existing techniques are required. Overall, there is a need for development of new tomographic techniques that would provide quantitative information of unknown parameters of interest, such as tomographic images on the concentration of molecules. In particular, information on the reliability of the tomographic images is required. The objective of the project is to develop quantitative tomographic imaging technique based on coupled physics of waves. In coupled physics imaging, contrast and resolution originating from different physical phenomena are combined. In the project, light, microwaves and ultrasound, i.e. waves, will be utilised through photoacoustic, thermoacoustic and acousto-optic effects. These techniques will be developed to produce tomographic images with an outstanding quantitative contrast in the sense of statistical information and modelling of uncertainties, combined with superior resolution and imaging depth. Most tomographic imaging techniques are ill-posed problems that need to be approached in the framework of inverse problems. In the project, a Bayesian approach to ill-posed inverse problems, which supports the quantitative nature of the problem, will be taken. In the project, mathematical modelling and computational methods will be developed in close connection with experimental system development. The research is founded on a strong understanding of the underlying physics of coupled physics problems, knowledge on instrumentation on the related fields and experimental tomography, and state-of-the-art methods of computational inverse mathematics, that all come together in the PI’s research group.

Mots-clés : inverse problems,bayesian methods,quantitative tomography,uncertainty quantification,imaging from coupled physics,photoacoustic computed tomography,thermoacoustic tomography,scientific computing
Projet ERC : MARCAN (Horizon 2020, appel 2015, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Earth system science
Entité participante : GEOMAR Helmholtz Centre for Ocean Research Kiel — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : IFM-GEOMAR
Type d'entité : Recherche
Financement ERC de l'entité : 779347.25 €

Topographically-driven meteoric (TDM) recharge is a key driver of offshore groundwater systems because sea level has been lower than at present for 80% of the last 2.6 million years. Groundwater has been implicated as an important agent in the geomorphic evolution of passive continental margins and the canyons that incise them. However, the geomorphic efficacy of groundwater remains dubious, and a diagnostic link between landscape form and groundwater processes remains poorly quantified, especially for bedrock and cohesive sediments. Obstacles that prevent going beyond the current state-of-knowledge include: (i) a focus on terrestrial contexts and a lack of mechanistic understanding of groundwater erosion/weathering; (ii) limited information on offshore groundwater architecture, history and dynamics. By addressing the role of TDM offshore groundwater in the geomorphic evolution of the most prevalent types of continental margins, MARCAN is expected to open new scientific horizons in continental margin research and bring about a step-change in our understanding of some of the most widespread and significant landforms on Earth. The project’s methodology is rooted in an innovative, multi-scale and multidisciplinary approach that incorporates: (i) the most detailed 3D characterisation of TDM offshore groundwater systems and their evolution during an integral glacial cycle, based on state-of-the-art marine data and hydrogeologic models, and (ii) the development of a comprehensive continental margin geomorphic evolution model, based on realistic laboratory simulations, accurate field measurements and advanced numerical solutions. By placing better constraints on past fluid migration histories, MARCAN will also have strong applied relevance, primarily by improving assessment and exploitation of offshore freshwater as a source of drinking water.

Mots-clés : geomorphology,groundwater,weathering,erosion,canyons,landscape evolution,continental margins
Projet ERC : TopFront (Horizon 2020, appel 2014, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Technion – Israel Institute of Technology — Pays : Israël — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1463666.27 €

Topological phases arise from a fascinating interplay between quantum mechanics and many-body physics. They exhibit an abundance of extraordinary properties, such as protected edge and surface modes, exotic particle statistics, and non-local correlations. These make them not only scientifically stimulating, but also appealing for ground-breaking future applications, such as quantum computing using non-Abelian systems. Their subtle nature often renders them hard to study theoretically, and even more so to detect and control experimentally. To date, only a small subset of them has been accessed in experiments. The purpose of this research program is to expand the scope of possible realizations of topological quantum matter, and to develop methods to detect, control and manipulate them. Two main research directions will be considered. The first will focus on utilizing defects to synthesize new non-Abelian systems. We will study the mathematical theory describing the defects, starting from microscopic considerations and aiming to achieve a unifying mathematical framework. New non-Abelian phases arising in networks of coupled defects will be explored. Protocols for controlling non-Abelian anyons and zero modes will be developed and optimized, aiming to minimize errors arising from imperfections in physical implementations. The second direction will explore the exciting possibility of inducing topological behaviour in non-equilibrium systems. Periodically driven systems, such as matter interacting with light, can exhibit anomalous topological phenomena with no analogue in static systems, which we intend to reveal and classify. We will study the unique many body physics arising from the interplay of topological Bloch-Floquet band structures, inter-particle interactions, and coupling to the environment. Finally, for both research directions we will consider possible experimental realizations in a variety of solid state and cold atom systems along with designated probes.

Mots-clés : topological phases,topological insulators and superconductors,topological quantum computation,dynamics of quantum many body systems
Projet ERC : TOPO-NW (Horizon 2020, appel 2015, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Weizmann Institute of Science — Pays : Israël — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1750000.0 €

Topological phases of matter have been at the center of intense scientific research. Over the past decade this has led to the discovery of dozens of topological materials with exotic boundary states. In three dimensional topological phases, scanning tunneling microscopy (STM) has been instrumental in unveiling the unusual properties of these surface states. This success, however, did not encompass lower dimensional topological systems. The main reason is surface contamination which is disruptive both for STM and for the fragile electronic states. We propose to study topological states of matter in pristine epitaxial nanowires by combining growth, fabrication and STM, all in a single modular ultra-high vacuum space. This platform will uniquely allow us to observe well anticipated topological phenomena in one dimension such as the Majorana end-modes in semiconducting nanowires. On a broader view, the nanowire configuration intertwines dimensionality and geometry with topology giving rise to novel topological systems with high tunability. A vivid instance is given by topological crystalline insulator nanowires in which the topological symmetry protection can be broken by a variety of perturbations. We will selectively tune the surface states band structure and study the local response of massless and massive surface Dirac electrons. Tunability provides a higher degree of control. We will utilize this to realize topological nanowire-based electronic and spintronic devices such as a Z2 pump and spin-based Mach-Zehnder interferometer for Dirac electrons. The low dimensionality of the nanowire alongside various singularities in the electronic spectra of different topological phases enhance interaction effects, serving as a cradle for novel correlated topological states. This new paradigm of topological nanowires will allow us to elucidate deep notions in topological matter as well as to explore new concepts and novel states, thus providing ample experimental prospects.

Mots-clés : topological insulators,topological crystalline insulators,nanowire,majorana
Projet ERC : MiTopMat (Horizon 2020, appel 2016, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Board of the Swiss Federal Institutes of Technology — Pays : Suisse — Rôle : Partner
Acronyme de l'entité : ETH Zurich
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1652463.0 €

Topological semi-metals such as Cd3As2 or TaAs are characterized by two bands crossing at isolated points in momentum space and a linear electronic dispersion around these crossing points. This linear dispersion can be mapped onto the Dirac- or Weyl-Hamiltonian, describing relativistic massless fermions, and thus relativistic phenomena from high-energy physics may appear in these materials. For example, the chirality, χ=±1, is a conserved quantity for massless fermions, separating the electrons into two distinct chiral species. A new class of topological electronics has been proposed based on chirality imbalance and chiral currents taking the role of charge imbalance and charge currents in electronics. Such devices promise technological advances in speed, energy efficiency, and quantum coherent processes at elevated temperatures. We will research the basic physical phenomena on which topological electronics is based: 1) The ability to interact electrically with the chiral states in a topological semi-metal is an essential prerequisite for their application. We will investigate whether currents in the Fermi arc surface states can be induced by charge currents and selectively detected by voltage measurements. 2) Weyl materials are more robust against defects and therefore of interest for industrial fabrication. We will experimentally test this topological protection in high-field transport experiments in a wide range of Weyl materials. 3) Recently, topological processes leading to fast, tuneable and efficient voltage inversion were predicted. We will investigate the phenomenon, fabricate and characterize such inverters, and assess their performance. MiTopMat thus aims to build the first prototype of a topological voltage inverter. These goals are challenging but achievable: MiTopMat’s research plan is based on Focused Ion Beam microfabrication, which we have successfully shown to be a promising route to fabricate chiral devices.

Mots-clés : topological matter,dirac,weyl
Projet ERC : CASTLES (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Centre national de la recherche scientifique — Pays : France — Rôle : Partner
Acronyme de l'entité : CNRS
Type d'entité : Recherche
Financement ERC de l'entité : 1024630.0 €

Topology provides mathematical tools to sort objects according to global properties regardless of local details, and manifests itself in various fields of physics. In solid-state physics, specific topological properties of the band structure, such as a band inversion, can for example robustly enforce the appearance of spin-polarized conducting states at the boundaries of the material, while its bulk remains insulating. The boundary states of these ‘topological insulators’ in fact provide a support system to encode information non-locally in ‘topological quantum bits’ robust to local perturbations. The emerging ‘topological quantum computation’ is as such an envisioned solution to decoherence problems in the realization of quantum computers. Despite immense theoretical and experimental efforts, the rise of these new materials has however been hampered by strong difficulties to observe robust and clear signatures of their predicted properties such as spin-polarization or perfect conductance. These challenges strongly motivate my proposal to study two-dimensional topological insulators, and in particular explore the unknown dynamics of their topological edge states in normal and superconducting regimes. First it is possible to capture information both on charge and spin dynamics, and more clearly highlight the basic properties of topological edge states. Second, the dynamics reveals the effects of Coulomb interactions, an unexplored aspect that may explain the fragility of topological edge states. Finally, it enables the manipulation and characterization of quantum states on short time scales, relevant to quantum information processing. This project relies on the powerful toolbox offered by radiofrequency and current-correlations techniques and promises to open a new field of dynamical explorations of topological materials.

Mots-clés : topological insulators,radiofrequency transport
Projet ERC : FORCE-UI (Horizon 2020, appel 2019, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Computer science and informatics
Entité participante : Lancaster University — Pays : Royaume-Uni — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

Touch input is the universal approach for communicating intention to interactive computing systems. However, touchscreens are flat, solid surfaces that fail to reproduce the qualities of real-world object interaction (e.g. deformation, stiffness, springiness). Further, their expressivity is fundamentally bounded by a single measurable dimension: contact with a solid, touch-sensitive surface. This project will radically increase the expressivity of touchscreen-based interaction by co-locating three force modalities into a single visual display surface (force input, resistive- and kinetic- force feedback). This will create a new paradigm for Human-Computer Interaction (HCI): Force Responsive Deformable User Interfaces (FRUI). FRUIs will allow users to ‘push through’ a display and for the display to ‘push back’. To achieve this ambitious goal, I will combine innovative hardware prototyping with experimental computer science and psychophysical study methodologies to complete four key research objectives: (1) Develop novel engineering approaches to construct FRUI; (2) Empirically characterise humans’ capabilities and responses during interaction with FRUI; (3) Construct conceptual models, metaphors, and principles for user interaction with FRUI; (4) Evaluate the expressivity, efficiency, and user satisfaction of FRUIs. I am considered an international leader in the development of shape-changing interfaces (interfaces whose physical geometry adapts to underlying digital content), as evidenced through my strong research track record (including two recent agenda-setting papers at the premier HCI conference), international community leadership, and external grant success. This background ideally places me to conduct all aspects of this highly ambitious programme of work. FORCE-UI has the potential to revolutionise touch input, and in doing so will have a significant impact on society’s use of interactive systems.

Mots-clés : deformable user interface,force input,force output,touch input,display