Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : ALIVE (Horizon Europe, appel 2023, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Texts and Concepts
Entité participante : Université Radboud de Nimègue — Pays : Pays-Bas — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 187745.54 €

Avicenna (Ibn Sīnā, d. 428/1037) is among the most influential philosophers in history and the most important philosopher of the Islamic tradition. He is described as a Mozart-type Wunderkind, who very early had completed his education and perfected his understanding of reality. Yet, throughout his life, Avicenna was also an eager student of his teachers or himself a dedicated teacher to his students – leading to the key-question of ALIVE: to what extent have Avicenna’s personal relations with his peers influenced the formation and formulation of his own philosophy? Did he reform or reformulate his thoughts in light of his personal interactions? Modern scholarship on Avicenna has often evaded these questions, frequently referring to his autobiography, according to which he supposedly never added anything to his views after his eighteenth birthday. What is more, scholars appear either unaware of the existence of sources that allow the examination of Avicenna’s potential indebtedness to and interaction with his peers or deterred by the challenges involved in exploring them systematically. As a result, the immediate context of Avicenna’s intellectual formation remained a surprisingly understudied area of research in defiance of its enormous potential for new insights not only into particular parts of his oeuvre but into his philosophy as a whole. ALIVE offers a radically new way of approaching Avicenna by studying four unique source texts that enable us to “circle in” on his intellectual upbringing and development, thereby providing an entirely novel paradigm for all future investigation in the field. At the same time, ALIVE will make an important contribution to the Digital Humanities by furnishing an online platform that will facilitate the study of diverse and difficult textual corpora for both ALIVE and future projects sharing these challenges.

Mots-clés : arabic islamic philosophy,digital humanities,avicenna
Projet ERC : ENRICH T-BRAIN (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Life Science
Panel : Neuroscience and Disorders of the Nervous System
Entité participante : Vlaams Instituut voor Biotechnologie — Pays : Belgique — Rôle : PI
Acronyme de l'entité : VIB
Type d'entité : Recherche
Financement ERC de l'entité : 1499650.0 €

T cells are part of the adaptive immune response. Breaking the dogma of the brain immune privilege I demonstrated the presence of T cells in the healthy brain. In the mouse brain they regulate neuronal morphology and behavior. Surprisingly, brain T cells respond and proliferate upon exposure to an enriched environment (EE), suggesting a connection between neural activity and brain T cells. EE involves motoric, sensory and social stimulation. Exposure of rodents to EE increases neurogenesis, enhances learning and memory, with proven beneficial effect in neuropathology. How brain T cells can respond to EE and eventually modify the brain is unknown. I hypothesize that upon EE, T cells adapt their molecular profile and acquire an immunomodulatory phenotype to support the changes occurring in the brain. My overarching goal is to understand how EE modulates immune-brain interactions and to harness emerging discoveries to develop novel therapeutic interventions for neurodevelopmental disorders, that mimic the beneficial effects of EE. Currently, research into brain functions of T cells is limited by absence of research tools to deplete T cells in the brain only. The proposed project will overcome these limitations by developing a novel gene therapy approach for depleting brain T cells . First, I will investigate how EE influences brain immunity. Then I will take the opposite approach, investigating whether and how brain immune cells act as a necessary mediator of EE-induced brain plasticity, making use of the new nanobody-based tool to deplete brain T cells. These complementary approaches will allow me to mechanistically decipher how experience influences interactions between the brain and the immune system. Finally, using the Fragile X mouse model of Autism, I will translate the knowledge gained from brain resident T cells into impactful proof-of-concepts for treating neurological diseases and mimicking the benefits of environmental enrichment through immunotherapy

Mots-clés : brain resident t cells,microglia,brain plasticity,fraglie x syndrome,gene therapy
Projet ERC : LEAD (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Soci al World and Its Interactions
Entité participante : Université de Pennsylvanie — Pays : Etats-Unis — Rôle : Partner
Acronyme de l'entité : Penn
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 250225.0 €

Early adolescence is a key window for human development. Strategic timing of interventions during this life stage may seize opportunities and prevent risks; bolster the impact of earlier investments; and ease damages from previous adversity. Yet evidence on whether such programs can fulfil this potential, for which children, and through which channels, is scant, especially in low-resource settings, where 90% of the world’s 1.2 billion adolescents live. I will tackle these gaps by relying on a cohort of ~2,500 children approaching early adolescence. In 2015, this sample participated in a trial evaluating quality preschool education in Ghana and has been followed-up since: the program improved child development through middle childhood. I will re-randomise this sample at 12 years to test a parenting skills program to enhance early adolescent development through improved parenting support and parent-adolescent interactions. Children and parents will be re-interviewed when children are 13, 15, and 17 years through mixed-method data collection. Outcomes include adolescent social-emotional and academic skills, health (including stress biomarkers), and adult-life transitions. This data will allow testing dynamic complementarities between interventions during early childhood and early adolescence, or whether interventions in adolescence might compensate for earlier adversity in the short- and longer-term. Methodologically, these questions can be convincingly studied only if data are available for the same individuals over time, and if variations in exposure to early childhood and early adolescence programs are exogenously driven. This is the first study that addresses both requirements, providing a breakthrough. Heterogeneity by child gender and socioeconomic status, and mechanisms are further research foci. LEAD’s high-risk components are well-balanced by my in-depth knowledge of the field, methods, and study context, with high potential for scientific and societal impact.

Mots-clés : human development early adolescence early childhood intervention research child development child poverty inequality learning social emotional skills health health behaviour low and middle income countries gender social policy for children and adolescents in developing countries child development in context risk and resilience for children in situation of adversity lifecourse
Projet ERC : MotionPicture (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Systems and Communication Engineering
Entité participante : Italian Institute of Technology — Pays : Italie — Rôle : PI
Type d'entité : Recherche
Financement ERC de l'entité : 1497000.0 €

Measuring the molecular dynamics and interactions of biomolecules in live cells is crucial for understanding cellular mechanisms. While recent advances in super-resolution fluorescence microscopy have enabled molecular-level resolution in fixed samples, capturing dynamics in live cells remains a major challenge. Conventional methods for studying molecular dynamics struggle with high fluorophore concentrations, photobleaching, and the need for extensive prior knowledge about the setup and sample. In addition, measuring the molecular diffusion properties without knowing the local viscosity complicates the study of anomalous diffusion dynamics.  The overall goal of the MotionPicture project is the development of a platform based on optical microscopy with massive information content to quantify molecular dynamics and local viscosity with unprecedented detail, speed, and ease of use. The project involves the construction of a photon-resolved microscope combining fluorescence and Brillouin microscopy. We will use various methods to shape and move the fluorescence excitation beam and tag every emitted photon with multiple signatures, such as spatial information, time of arrival, and energy. We will develop a deep-learning based analysis framework to extract molecular dynamics information from the high-dimensional data set. In parallel, we use label-free Brillouin microscopy to correlate the fluorescence data with the biomechanical properties of the same sample. Compared to the state-of-the-art, this project aims to derive a more complete picture of the molecular dynamics and in a faster, more robust, less phototoxic, and more user-friendly way.  The unique combination of the fluorescence and Brillouin information will have significant potential for the study of biomolecular dynamics. We will demonstrate this potential in the context of biomolecular condensates, which play a vital role in many processes and whose behavior has been associated with several diseases.

Mots-clés : fluorescence correlation spectroscopy,fluorescence fluctuation spectroscopy,fluorescence lifetime,molecular dynamics,brillouin microscopy,biomolecular condensates,
Projet ERC : GeneCKD (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Life Science
Panel : Prevention,  Diagnosis and T reatment of Human Diseases
Entité participante : Sheba Medical Center — Pays : Israël — Rôle : PI
Type d'entité : Recherche
Financement ERC de l'entité : 1800000.0 €

Chronic Kidney Disease (CKD) is a public health challenge affecting millions globally. Patients have increased risks of mortality, morbidity, and progression to end-stage kidney disease (ESKD). CKD is often clinically silent, disease mechanisms are unclear and targeted therapies are unavailable. Recent studies support considerable contributions of underappreciated monogenic aetiologies in adults with CKD, suggesting that most inherited kidney diseases remain undiagnosed, untreated and poorly understood. Our overarching objective is to unravel the genetic basis of CKD towards early diagnosis and gene-based therapy. We therefore established the Israeli ESKD genetic cohort and already recruited clinical data and samples from 2,000 participants with ESKD. Our main objectives are: 1) to unravel known and novel CKD genes by interrogating high-risk groups for genetic CKD using next generation sequencing on a population level; 2) to study novel monogenic CKD disease mechanisms by using patient-derived kidney organoids and mutation-specific mouse models. Specifically, we will study a newly identified WDR19 mutation leading to many adult onset-ESKD cases in the Israeli Arab-Druze population; and 3) to develop gene-based targeted therapies for CKD. We will focus initially on monogenic CKD secondary to gain-of-toxic-function mutations in UMOD (encoding uromodulin, a kidney-specific protein). This relatively frequent adult CKD aetiology accounts for 0.5-2% of CKD cases worldwide. Altered uromodulin?s toxic effect is suitable for novel RNA-based therapies. Gene silencing of uromodulin with antisense oligonucleotides will be performed and studied, using a patient-derived in vitro model as well as a Umod mouse model. This project will improve CKD classification and clinical management, reveal disease mechanisms as well as novel treatments. In a broader perspective, this project will set the stage for future clinical trials and for other RNA-based gene-specific CKD treatments.

Mots-clés : chronic kidney disease ckd,end stage kidney disease eskd,monogenic ckd,wdr19,umod,asos,genetic kidney disease
Projet ERC : EmbryoAxes (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Life Science
Panel : Integrative B iology : from Genes and Genomes to S ystems
Entité participante : Max Delbrück Center — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : MDC
Type d'entité : Recherche
Financement ERC de l'entité : 1498683.0 €

One of the most remarkable processes in biology is how animals develop from a single fertilized egg within a short time of rapid growth and an explosion in spatial and cellular diversity. Embryonic development is highly deterministic and consistent among different embryos and conserved across species. Astonishingly, embryos reuse the same signaling pathways in diverse developmental contexts to robustly pattern tissues. The advent of single-cell genomics in the last decade has allowed to chart the phenomenology of cellular differentiation at unprecedented resolution and scale. Yet, moving from such single-cell descriptions to models of how embryonic tissues achieve robustness and precision in their differentiation remains exceedingly difficult. To this end, we will develop new algorithms that will infer the spatiotemporal dynamics of differentiating tissues from space-, time- and lineage-resolved data. Tissues will be modelled as groups of proliferating and interacting cells distributed in space and moving along transcriptional, epigenetic and signaling manifolds. Focusing on the developmental stages of gastrulation and early organogenesis, we will reconstruct the spatiotemporal trajectories of cells together with the dynamics of their local niches. These trajectories will serve as the input to mathematical models that will predict local changes in a cell’s state from its signalome, epigenome and transcription factor repertoire. Using zebrafish embryos as a high-throughput system of vertebrate development, we will systematically test these models through time-dependent, combinatorial perturbations with a multiomic read-out. My overall goal is to develop quantitative, data-based models of how transcriptional, epigenetic and intercellular changes at the cellular level translate into robust and deterministic dynamics at the tissue level and to apply these methods to dissect how positional information and cell fate commitment emerges in the vertebrate embryo.

Mots-clés : spatial transcriptomics trajectory inference cell cell communication embryonic development lineage tracing optimal transport pattern formation gastrulation epigenetics
Projet ERC : ProletGard (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Study of the Human Past
Entité participante : Kassák alapítvány — Pays : Hongrie — Rôle : PI
Type d'entité : Recherche
Financement ERC de l'entité : 1465135.0 €

This project investigates the interaction between workers’ movements and the transnational scene of modern art. The avant-garde forever transformed the relationship between art and everyday life. This project argues that this shift not only dynamized the art world but also extended well beyond the confines of the cultural sphere, transforming the working-class communities in the successor states of the Austro–Hungarian Empire as well, where avant-garde art played a pivotal role in creating a workers’ movement counterculture. The project postulates that the transnational avant-garde scene, and especially the related network of periodicals, enabled reciprocal interactions. The amalgamation of pre-existing working-class practices in the region with avant-garde techniques also had an impact on global modernisms. To explore these interactions, the project assembles an interdisciplinary team of seven researchers to analyze how working-class and avant-garde publications were circulated, received, and produced in this region between the two wars. The project comprises three thematic components, examining: 1) how related periodicals transcended administrative and linguistic boundaries of newly established nation-states; 2) novel reading and performative practices; 3) the extent to which these publications served as arenas of conflict and negotiation among various cultural trends within the heterogeneous milieu of workers’ movements. By examining avant-garde journal production and their everyday use in East Central Europe, the project not only seeks to readjust the Western-centric viewpoint on modern art networks but also establishes the basis for a comprehensive exploration of the cultural history of working-class groups in the region and beyond. By rewriting the history of interwar avant-garde press from below, the project analyzes East Central European modernisms on two scales, as inextricably linked both to local workers’ movements and the transnational avant-garde press.

Mots-clés : workers movements,east central europe,avant garde,cultural transfers
Projet ERC : DryCO2 (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Earth System Science
Entité participante : Centre national de la recherche scientifique — Pays : France — Rôle : PI
Acronyme de l'entité : CNRS
Type d'entité : Recherche
Financement ERC de l'entité : 1499176.0 €

Chemical reactions in the unsaturated zone in Earth's shallow subsurface, where pores are filled with a mixture of fluid and gas, support life on our planet and have a profound influence on the global carbon cycle and climate. Gas-driven mineral weathering reactions not only provide nutrients essential to life but serve to regulate atmospheric CO2 concentrations and climate, and are facilitated in the unsaturated zone where reactive gases like CO2 and O2 are readily transported. Earth's climate has experienced major fluctuations over its history, and is currently changing rapidly due to human activities. Climate change impacts the size and water content of the unsaturated zone, and therefore the rates of mineral weathering. At present, prediction of the impacts of changes in water saturation, CO2 concentration, and temperature on mineral weathering rates is hindered by an incomplete understanding of the controls on mineral weathering in the unsaturated zone. DryCO2 will elucidate the physical and chemical controls on gas-driven mineral weathering in the unsaturated zone to evaluate climate evolution over Earth's history, to optimize engineered CO2 removal for climate change mitigation, and to forecast the impact of future anthropogenic climate change on the mineral weathering reactions that store CO2 and release nutrients. DryCO2 will comprise five work packages, and combines experimental studies at multiple scales in the laboratory and field, analysis of key field samples, and multi-scale reactive transport modelling. This multi-scale, multi-tool approach will allow DryCO2 to quantify the effects of CO2 concentration and changes in water availability on mineral weathering reactions from the mineral surface to the global scale in a comprehensive fashion.

Mots-clés : co2 storage carbon cycle mineral weathering kinetics carbon mineralization reactive transport modelling experimental geochemistry unsaturated zone critical zone
Projet ERC : MECERDIS (Horizon Europe, appel 2022, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Materials Engineering
Entité participante : Helmholtz-Gemeinschaft — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : HGF
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1402570.0 €

Advanced functional ceramics play an indispensable role in our modern society and they are typically engineered by point defects or interfaces. The potential of dislocations (one-dimensional atomic distortions) in functional ceramics has been greatly underestimated until most recently. Exciting proofs-of-concept have been demonstrated for dislocation-tuned functionality such as electrical conductivity, superconductivity, and ferroelectric properties, revealing a new horizon of dislocation technology in ceramics for a wide range of next-generation applications from sensors, actuators to energy converters. However, it is widely known that ceramics are hard (difficult to deform) and brittle (easy to fracture), making it a great challenge to tailor dislocations in ceramics. This pressing bottleneck hinders the dislocation-tuned functionality and the true realization of dislocation technology. To break through this bottleneck, MECERDIS employs mechanics-guided design coupled with external fields (thermal, light illumination, electric field) to manipulate the 3 most fundamental factors of dislocation mechanics: nucleation, multiplication, and motion. These external fields greatly impact the charged dislocation cores in ceramics and open new routes for mechanical tuning. With these novel approaches, MECERDIS aims to generate, control, and stabilize dislocations in large plastic volumes up to mm-size with high density up to 10^15/m^2 to allow large-scale preparation for functionality assessment. Another essential benefit is, dislocations are an effective tool to combat the brittleness of ceramics by improving the damage tolerance and fracture toughness. MECERDIS will not only fulfil the key prerequisite of dislocation-tuned functionality but also secure the mechanical integrity and operational stability of future dislocation-based devices. With its success, MECERDIS will define a new paradigm of engineering functional ceramics using mechanics and dislocations.

Mots-clés : dislocation
Projet ERC : BARD (Horizon Europe, appel 2023, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Fundamental Constituents of Matter
Entité participante : DESY — Pays : Allemagne — Rôle : PI
Type d'entité : Recherche
Financement ERC de l'entité : 1479375.0 €

The Standard Model (SM) of particle physics provides a cogent, yet incomplete, description of matter and its fundamental interactions. Many theories aim to describe particles and forces beyond the SM of particle physics, but after ten years of data taking at the Large Hadron Collider (LHC) and hundreds of experimental measurements, only one deviation from the predictions of the SM has been observed .The Standard Model (SM) of particle physics provides a cogent, yet incomplete, description of matter and its fundamental interactions. Many theories aim to describe particles and forces beyond the SM of particle physics, but after ten years of data taking at the Large Hadron Collider and hundreds of experimental measurements, only one deviation from the predictions of the SM has been observed in a series of semi-leptonic decays of B-mesons (B anomalies). It is undeniable though that the third generation of fermion families have a special role in the SM and beyond and their study represents the pathway towards accessing new particles and forces. Taking into account the current exploitation of LHC data and the constraints set to new particles and forces in recent years, it is time to devote greater scientific focus to the search for new light particles that specially couple to third generation quarks. These particles might be within reach of the LHC, but haven’t been discovered yet due to experimental limitations (triggers). BARD is a new experimental technique that overcomes the limitations of light particle searches and provides a new way of performing data analysis searches for these particles. BARD will achieve this goal by advancing high-momentum resonance search methods using tools specific to the low-momentum B-physics field, in order to increase the available dataset and sensitivity for di-b-jet resonance particles. BARD’s innovation, exploiting the full LHC Run-3 data-taking, will provide a concrete chance at discovering these new particles.

Mots-clés : light b jet resonances b hadron decays dark matter trigger atlas large hadron collider beyond the standard model machine learning