Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : JUSTAM (Horizon 2020, appel 2016, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : University of London — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : U. London
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1483992.0 €

The project will investigate the social, cultural and cognitive bases of justice, or the morally correct assignment of goods and evils, with a focus on the indigenous peoples of Western Amazonia. It will develop an analysis of issues ranging from emotions, fairness, entitlement and equality in contexts of resource distribution, to punishment, vengeance, and attributions of responsibility. This will enlarge our understanding of how and why patterns of moral judgement vary across cultures, with particular attention paid to the role played by cultural constructions of personhood. The current situation of rapid social change in Amazonia, driven largely by the increased presence of the state in everyday life, provides a unique opportunity for assessing how morality and ethics are shaped by social conditions such as the size of networks of cooperation, processes for generating consensus, and the management of conflicts and disputes. This will be used to address longstanding questions concerning the evolution of morality, including how fairness is linked to cooperation within ever larger groups. The innovative methodology, combining ethnography with experiments and games adapted from psychology, economics, and experimental philosophy, will allow for a vastly more comprehensive set of data on justice in action than has previously been achieved. This will permit the elaboration of a sophisticated and distinctively Amazonian theory of justice, grounded in emotional responsiveness to others and respect for personal autonomy, that is capable of entering into critical dialogue with mainstream Western theories and understandings, while also challenging a number of dominant stereotypes of small-scale, non-state societies. The results will further be used to formulate a general framework for development projects and policy interventions with indigenous peoples, which could drastically improve their success rate and potentially be adapted for use in a range of global contexts.

Mots-clés : justice,experimental philosophy,social psychology
Projet ERC : Pepe-prod (Horizon 2020, appel 2014, Proof of concept grants)
Entité participante : University of Oxford — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 135776.0 €

The project will take a new technique devised in my ERC Advanced Investigator grant that measures implicit social biases in perception and applies it to the fields of sales and marketing. These fields have previously been reliant on paper-and-pencil tests which have a variety of problems including the faking of responses and vulnerability to demand characteristics. I have generated proof-of-principle evidence that my novel, tablet based measures of bias can be adapted to (i) measure product preference, (ii) predict the likelihood of an individual being persuaded to buy a product, and (iii) modify product value through self-association. In my PoC grant I will carry out field testing of the new products to ensure that they are practical in the real-world, do link and predict real-world purchasing behaviour ,and are perceived as useful by users. Commercially viable forms of the tablet-based tests will be developed and evaluated for robust and efficient behavioural measurement and reporting in the field.

Mots-clés : cognitive biases,self bias,product choice
Projet ERC : NONUNE (Horizon 2020, appel 2019, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Earth system science
Entité participante : Thermo Fisher Scientific (Germany) — Pays : Allemagne — Rôle : Partner
Type d'entité : Organismes privés (hors enseignement)
Financement ERC de l'entité : 976717.0 €

The project will use a set of innovative techniques to study the two major events that precede classical, uniformitarian geology. We will search for crystallised remnants of the primordial terrestrial magma ocean and examine the consequences of our observations for mantle dynamics. Crystallisation of the dominant lower mantle phase, bridgmanite, imparts a Mg and Si isotopic fingerprint to cumulates and evolving liquid of the magma ocean. Identifying the relicts of these small but distinctive fractionations requires application of our bespoke, high precision analytical protocols. As an integral part of this work, we will undertake coupled first principles calculations and petrological experiments to provide a benchmark documentation of the isotopic fractionations experienced by these two most abundant cation-forming elements in the silicate Earth. We will also date the global onset of plate tectonics from complementary geochemical signatures in two little-studied detrital minerals; Pb enrichment in continental K-feldspars and Mo depletion in rutiles from exhumed fragments of subducted crust. This work uses ground-breaking methodologies made possible by our unique, tribrid (mass-filter:collision-cell:multicollector) mass-spectrometer, Proteus. We will further develop this technology in collaboration with Thermo Fisher to produce a yet more capable next generation instrument. Our tribrid mass-spectrometer allows us to date single, detrital K-feldspars by laser ablation, using Rb-Sr internal isochrons constructed with analyses of host feldspar and sodic perthite exsolutions. Coupled with in situ Pb isotope analysis, we can calculate the U/Pb of the feldspar’s crustal protolith, which diagnostically tracks contributions from subduction.

Mots-clés : isotopic fractionation,mantle convection,magma ocean,continental growth
Projet ERC : QUIST (Horizon 2020, appel 2019, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Delft University of Technology — Pays : Pays-Bas — Rôle : PI
Acronyme de l'entité : TU Delft
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1873285.0 €

The promise of universal quantum computation stems from the remarkable behaviour of quantum states and the challenge is to gain control over their fragile nature. In topological quantum computation, information can be encoded nonlocally on Majorana states to provide inherent protection against noise, but operation is restricted to the trivial Clifford group. Spins in quantum dots do provide universal logic, but interactions are short-ranged. I propose to study the question whether these platforms can be united to overcome their limitations as a path toward large-scale quantum computation. The grand goal of this project is, therefore, to coherently transfer quantum information between spin and topological qubits. Our quantum material of choice is germanium, which can exhibit strong spin-orbit coupling, can provide long quantum coherence for single spins, and can make ohmic contacts to superconductors for hybrid superconductor-semiconductor systems. We will use two-dimensional germanium hetero structures and fabricate superconducting quantum dot devices. Qubits defined on the spin states of single holes will be electrically driven using the spin-orbit interaction and coupled through the exchange interaction. On linear chains of quantum dots we will pursue topological superconductivity, which we will consequently integrate in the spin qubit platform. We will then study their interaction to demonstrate controllable transfer of quantum information between hole spin and Majorana states. This research is presently at a fundamental stage and is thereby bound to produce exciting results where new physics may arise. The choice of the materials platform and its compatibility with semiconductor manufacturing promises for a successful adoption as building block for future quantum technology. Our long-term dream is to create a powerful platform where complex and emerging systems can be created, simulated, and computed to advance our general understanding of physics.

Mots-clés : silicon quantum electronics,spin qubits,gate defined quantum dots,proximity superconductivity
Projet ERC : NEUROMET (Horizon 2020, appel 2015, Starting grants)
Domaine scientifique : Life Science
Panel : Neuroscience and Disorders of the Nervous System
Entité participante : Institut national de la santé et de la recherche médicale — Pays : France — Rôle : Partner
Acronyme de l'entité : Inserm
Type d'entité : Recherche
Financement ERC de l'entité : 421332.38 €

The proper function of neuronal circuits in the adult brain relies heavily on glucose metabolism to ensure energy-demanding neuronal functions such as synaptic activity or long distance axonal transport. Deregulation of the energetic metabolism is strongly associated to many neurodegenerative diseases and has been linked to some neuropsychiatric diseases such as schizophrenia. However our current understanding of metabolic regulation in the developing brain and in particular in rapidly growing neurons is still fragmental. I recently identified a novel function for the kinase LKB1 in the control of axon outgrowth and terminal branching in the mouse cortex (Courchet et al. Cell 2013). This novel function of LKB1 involves the kinase NUAK1/ARK5, a poorly studied kinase related to the metabolic regulator AMPK. Furthermore our work uncovered a completely novel mechanism by which LKB1 and NUAK1 control terminal axon branching through the capture of mitochondria at nascent presynaptic sites. However the roles of presynaptic mitochondria in developing neurons and how they contribute to axon morphogenesis remain an open question. In this project I will to study how the regulation of glucose metabolism and mitochondria function by LKB1 and NUAK1 underlie neuron development and circuit formation in the neocortex. We will develop techniques combining live imaging of fluorescent metabolic reporters, functional metabolomics and in vivo manipulation of gene expression in mouse models to identify the relationship between glucose metabolism and axon development. My experimental plan will revolve around three independent aims that will tackle this question from a subcellular scale to circuits in vivo. Overall, this project will provide new insights into the molecular mechanisms underlying the development of the neocortex and will point out some of the consequences of metabolic imbalance on the development of the brain, a question that has many important implications for public health.

Mots-clés : neocortex,axon,mitochondria,lkb1,nuak1
Projet ERC : MULTILING-HIST (Horizon 2020, appel 2020, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : Max Planck Society — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : MPG
Type d'entité : Recherche
Financement ERC de l'entité : 580000.0 €

The proposal addresses the complex, multi-level dimensions of historical and contemporary multilingualism: (1) the presence of individual multilingualism in local and regional settings; (2) the characteristics and dynamics of such multilingual settings, in other words, societal multilingualism. The fundamental aim of the project is to reconstruct, explain and better understand the mechanisms and causality of the processes behind the emergence, continuity, reduction and loss (as well as possible re-emergence) of multilingualism in differing historical, geographical, social, political and cultural contexts. These goals address not only essential gaps in the state of knowledge, but also significant questions about the past and the present of human development. The project will embrace historical and contemporary multilingual milieux from four regions relevant for understanding the causal frameworks underlying multilingual trajectories: selected historical multilingual hotspots from Central-Eastern Europe, Mesoamerica, South Africa and the Archipelago of Vanuatu. They represent a diversity of pre-colonial, colonial and post-colonial contexts, ensuring a meaningful comparison. The case studies also offer a novel possibility to study the ‘invisibility’ of multilingualism and uncover its neglected history(ies). The research will focus on a broad range of rural communities and a smaller amount of urban contexts, thus permitting comparative insights into urban multilingualism. A multidisciplinary approach will combine in novel ways historical and present data, qualitative and quantitative methods as well as mathematical modeling, data-driven mapping and GIS mapping. Its expected results will provide informed diagnoses and predictions with huge potential for improving existing language policies and educational strategies oriented toward the preservation of linguistic-cultural diversity and sustainable multilingualism.
Projet ERC : MULTILING-HIST (Horizon 2020, appel 2020, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Warsaw — Pays : Pologne — Rôle : PI
Acronyme de l'entité : UW
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1283525.0 €

The proposal addresses the complex, multi-level dimensions of historical and contemporary multilingualism: (1) the presence of individual multilingualism in local and regional settings; (2) the characteristics and dynamics of such multilingual settings, in other words, societal multilingualism. The fundamental aim of the project is to reconstruct, explain and better understand the mechanisms and causality of the processes behind the emergence, continuity, reduction and loss (as well as possible re-emergence) of multilingualism in differing historical, geographical, social, political and cultural contexts. These goals address not only essential gaps in the state of knowledge, but also significant questions about the past and the present of human development. The project will embrace historical and contemporary multilingual milieux from four regions relevant for understanding the causal frameworks underlying multilingual trajectories: selected historical multilingual hotspots from Central-Eastern Europe, Mesoamerica, South Africa and the Archipelago of Vanuatu. They represent a diversity of pre-colonial, colonial and post-colonial contexts, ensuring a meaningful comparison. The case studies also offer a novel possibility to study the ‘invisibility’ of multilingualism and uncover its neglected history(ies). The research will focus on a broad range of rural communities and a smaller amount of urban contexts, thus permitting comparative insights into urban multilingualism. A multidisciplinary approach will combine in novel ways historical and present data, qualitative and quantitative methods as well as mathematical modeling, data-driven mapping and GIS mapping. Its expected results will provide informed diagnoses and predictions with huge potential for improving existing language policies and educational strategies oriented toward the preservation of linguistic-cultural diversity and sustainable multilingualism.
Projet ERC : QuantumMagnonics (Horizon 2020, appel 2014, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Karlsruhe Institute of Technology — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : KIT
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1117000.0 €

The proposed project will experimentally interface ferromagnets with superconducting quantum circuits to study dynamics within the magnet. To this end, magnonic elements made up by thin, structured magnetic films will be strongly coupled to the qubit. Superconducting qubits are ideal detectors due to their quantum limited back-action on the measured object and energy resolution. Spectroscopy and coherence measurements on the hybrid system will be made in order to address fundamental aspects such as spin wave generation, detection, coherence, or wave propagation down to mK temperatures and at ultra-low power (atto-watts). Amplitude and phase noise of spin wave resonators will be determined. At the final stage of the project, the quantum limited resolution of qubits will facilitate single magnon creation and detection. Quantum states are swapped between qubit and magnon, and superpositioned and entangled states will be explored. Monitoring the qubit response to its magnetic environment the low and high-frequency flux noise spectrum of spin waves will be inferred. The research methodology employs junctions, resonators, and qubits as research objects and detectors. The samples will be characterized at cryogenic temperatures by transport, magnetometry, resonator and qubit setups. Magnetic materials will be deposited and structured beneath or ontop the superconducting quantum circuits. Exploring spin wave dynamics in thin films by coupling to a superconducting qubit complements conventional measurement techniques based on photon, electron or neutron scattering methods, which require highly populated excitations. The project connects to and extends research objects of ground-breaking nature to open up new horizons for quantum, magnon and spin electronics. Magnetic material physics is enhanced by new research concepts such as quantum resolved spectroscopy and coherence measurements on intrinsic dynamic states.

Mots-clés : quantum detection of spin waves with superconducting resonators and qubits
Projet ERC : SIREM (Horizon 2020, appel 2019, Advanced grants)
Domaine scientifique : Life Science
Panel : Biotechnology and Biosystems Engineering
Entité participante : Weizmann Institute of Science — Pays : Israël — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2500000.0 €

The prosperity of plants and human beings is dependent on the outer layer of soil that makes up our planet’s shell. Curiously, a significant portion of plants' most precious elements, carbon and nitrogen, is secreted by roots into soil in the form of chemically-rich exudates. This is not merely 'dumping' of waste but rather the chemical language of plants, used in their underground communication with billions of detrimental and beneficial microorganisms. Yet, an important question remains to date: How do plants control and manipulate root metabolism and exudation in time and space to fine-tune this complex underground web of interactions to their benefit? The proposed project takes on this challenging question and aims to decipher the newly discovered process we term 'SIREM', for 'Systemic Induced Root Exudation of Metabolites'. SIREM is a fundamental feature of rhizosphere interactions, in which biotic stimuli occur locally and exudation in systemic parts of the root ‘conditions’ the rhizosphere environment to maintain plant fitness. SIREM objectives include: (i) dissecting the SIREM signaling pathways, focusing primarily on the mobile signal(s) and receiving proteins at the systemic root; (ii) discovery of the exudation machinery and its genetic control; and (iii) establishing the role of SIREM signaling and exudation-metabolites in shaping the rhizosphere microbiome. The unconventional integration of approaches in SIREM underscores the unique combination of our team's expertise in plant metabolism, computational biology, microbiome exploration and the application of cutting-edge analytical and molecular technologies for high-resolution spatial-temporal profiling. Outcomes of the project will have wide-ranging impacts on understanding systemic signaling and metabolic and transport systems in plants and are anticipated to drive the new biotechnological concept of 'Exudation Agriculture'.

Mots-clés : metabolomics,secondary metabolites,plant metabolism,root exudates,systemic response
Projet ERC : SPLICE3D (Horizon 2020, appel 2015, Advanced grants)
Domaine scientifique : Life Science
Panel : Molecules of Life: Biological Mechanisms, Structures and Functions
Entité participante : UK Research and Innovation — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : UKRI
Type d'entité : Recherche
Financement ERC de l'entité : 1069584.7 €

The protein coding sequences of the majority of eukaryotic genes are interrupted by non-coding introns. The spliceosome is an immense and intricate molecular machine that catalyses the excision of introns from pre-mRNAs and splicing together of exons to produce mature mRNA. This is a crucial process in eukaryotic gene expression and we aims to greatly increase our understanding of its molecular mechanism through cryoEM studies of the spliceosome. The spliceosome comprises five canonical subunits, namely U1, U2, U4, U5 and U6 small nuclear ribonucleoprotein particles (snRNPs) and numerous non-snRNP factors. During the initial stages, U1 and U2 snRNPs bind the 5’-splice site and branch point of pre-mRNA, respectively, and the spliceosome is fully assembled when the U4/U6.U5 tri-snRNP is recruited. The spliceosome then becomes activated through extensive structural and compositional remodeling which leads to the formation of the catalytic RNA core. Recently we determined the crystal structure of U1 snRNP and two key spliceosomal proteins: Prp8, which harbours the catalytic RNA core and Brr2, which catalyses the rearrangement of the RNA interaction network and plays a crucial role in spliceosomal activation. We also solved the structure of U4/U6.U5 tri-snRNP by cryoEM and revealed the nearly complete organisation of U5 snRNA and U4/U6 snRNA and over 30 proteins within this complex, providing crucial insights into the activation mechanism and the active site of the spliceosome. Building on these achievements we aim to determine the structure of the entire spliceosome stalled at different steps of the splicing reaction so that the molecular mechanism of pre-mRNA splicing is understood in structural terms. This will enormously increase our understanding of this fundamental process of eukaryotic gene expression and such knowledge will clarify the molecular pathology of diseases caused by mutations in spliceosomal components and may facilitate therapeutic intervention.

Mots-clés : pre mrna splicing,cryoem,spliceosome,rna structure,rna protein complexes