Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : COSE (Horizon Europe, appel 2021, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Texts and Concepts
Entité participante : Helmholtz-Gemeinschaft — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : HGF
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1997348.75 €

What lies beneath the surface of computational artworks? Online pieces have ‘roots’ that extend much deeper than the flat screen monitors on which we view them – they may even be distributed, occupying multiple sites on the Internet. Nobody has ever been able to see the responsive and connective agency of these works with their own eyes. COSE sets out to reveal the inner workings of code-based artworks, as well as their embeddedness in the various niches of the World Wide Web. Shedding light on this black box will enable us to gain a fuller appreciation of these artworks and empower scholars in the humanities as they begin to confront programmed works, providing analytical instruments and a general understanding of our media-technological condition. The artistic pieces under analysis are all hidden, concealed, or somehow withdrawn due to the networked situation into which they were inserted. As art historians prefer to dedicate themselves to the surface features, they tend to overlook such works or ignore important aspects of their design: codes, files, software performance. As these interventions operate in non-standard locations, they implicitly highlight the circumstances where artists saw opportunities to critically exploit the specifics of the net in order to post a message. COSE will offer a new view of the Internet through the lens of these artworks that reclaim the right to productively diversify Internet access and usage. In order to uncover these much-neglected aspects, an interdisciplinary team will complement art historical methods with approaches from media, game and code studies, software forensics and visual design. Taking the artworks as the starting point, the Internet will be presented as complex of activated affordances rather than as yet another node-graph-diagram. COSE will develop an original pictorial language to generate immersive views into the specific ‘machine rooms’ of the artworks and their ecosystems as a processual deep topology.

Mots-clés : net art,digital humanities,new media art,
Projet ERC : ModERN (Horizon Europe, appel 2021, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Texts and Concepts
Entité participante : Sorbonne Université — Pays : France — Rôle : Partner
Acronyme de l'entité : Sorbonne U
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1251528.0 €

The Enlightenment has long been associated with the rise of modern Europe, and more generally with the concept of a typically European Modernity that took root in its wake. What it means to be ‘modern’ is indelibly bound up with our understanding of the Enlightenment’s core concepts: reason, religious toleration, civic virtue, political liberty, and scientific progress, to name but a few. For some, the Enlightenment is an essentially philosophical matter; for others it was and remains deeply political. Whatever the case may be, one thing is certain: for better or worse, it is widely accepted that the Enlightenment ushered in a new, modern era in both politics and philosophy, beginning in the 1790s and continuing today. The role of 18th-century ideas in this modernising process, and by proxy, the books that came to embody them, has long been the subject of intense scholarly debate, primarily concerned with the social and intellectual causes of the French Revolution. As a result, the field of Enlightenment studies today continues to privilege a relatively small canon of writers—primarily those that participated in the more ‘radical’ strains of Enlightenment thought in France. This is only one version, or vision, of the Enlightenment, however, albeit one that tends to dominate contemporary discourse. This project aims to fundamentally re-evaluate this interpretation of the Enlightenment and its actors by expanding the knowledge base on which these previous claims have been made; not only in terms of the diversity of authors and texts included, but also in the development of new digital techniques for identifying and analysing 18th-century information networks and their subsequent reception. In so doing, ModERN will move Enlightenment studies in a decidedly new direction; one that is both more comprehensive and more systematic in terms of its relationship to the existing digital cultural record, and one that likely challenges subsequent narratives of European Modernity.

Mots-clés : digital humanities,enlightenment studies,intellectual history,book history
Projet ERC : ENERGISED (Horizon Europe, appel 2021, Consolidator grants)
Domaine scientifique : Life Science
Panel : Physiology in Health, Disease and Ageing
Entité participante : Sorbonne Université — Pays : France — Rôle : PI
Acronyme de l'entité : Sorbonne U
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1364000.0 €

Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are immune-related disorders characterized by inappropriate gut inflammation. Their incidence has increased dramatically in Western countries in recent decades, supporting a role for environmental factors. Despite the development of new treatments, IBD are insufficiently controlled in a large proportion of patients, inducing an alteration in quality of life and a socioeconomic burden. A better understanding of the pathogenesis and identification of new therapeutic targets are therefore urgently needed. In this context, the gut microbiota has been recognized as a strong actor in IBD. Additionally, an alteration in intestinal and immune cell energy metabolism has been suggested in the pathogenesis. Classical host-microbe interaction concepts rely on the recognition of conserved microbial motifs by innate immunity sensors or on the action of microbial molecules on a host cell receptor. However, energy metabolism plays a crucial role in mounting the appropriate cellular response, and emerging data indicate that the gut microbiota may directly affect it. I hypothesize that the altered gut microbiota in IBD contributes to the impairment of host cell energy metabolism and pathogenesis. The aims of ENERGISED are to (i) identify the microorganisms and microbiota-derived metabolites impacting host cell energy metabolism and the mechanisms involved and (ii) decipher the consequences of gut microbiota alterations on host cell energy metabolism in IBD and design new microbiota-based therapeutic strategies to manipulate the host cell energy state in IBD.  This challenging project involves multidisciplinary aspects from microbiology to immunology, metabolism, and medicine; the use of multiple cutting-edge technologies; and translational analysis from mice to humans. In addition to its scientific importance, it will have societal impacts due to the identification of new therapeutic strategies.

Mots-clés : microbiome,cellular energy metabolism,inflammatory bowel disease
Projet ERC : GlobSlav (Horizon Europe, appel 2023, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Study of the Human Past
Entité participante : Académie royale néerlandaise des arts et des sciences — Pays : Pays-Bas — Rôle : PI
Acronyme de l'entité : KNAW
Type d'entité : Recherche
Financement ERC de l'entité : 1999999.0 €

Historiography suggests that the different ways in which people were enslaved (e.g. through war, kidnapping, debt, birth) mattered greatly for how they resisted and were treated under slavery. These links remain largely unexplored, but are vital to re-understanding the history and present of slavery. This project studies how responses to modes of enslavement impacted i) slave trade patterns, ii) labelling and treatment, and iii) strategies of enslaved across the Indian Ocean, Indonesian archipelago and Atlantic.  The project employs a global (micro)historical approach to study the uniquely detailed material from colonial court records containing voices of enslaved and other actors as witnesses, victims or accused. These provide a lens on modes of enslavement, practices of slavery and strategies of enslaved that surface both ‘transgressions’ and the considered ‘normal’, creating multiplicities of views on ‘circumstances’ and ‘backgrounds’. Indexation and proven qualitative methods are used to analyse the court records. The rich and increasing digitized colonial archives allow for contextualization strategies and expanding on innovative digital research infrastructure (GLOBALISE).  The project team tackles key cases related to the key European empires (Portuguese, Spanish, French, English, Dutch). Fruitful team synergy is created by ‘light’ collective efforts that allow connecting, comparing and analyzing research results from the subprojects (e.g. on the same groups of enslaved, as Balinese, Pulaya or Malagasy, as they occur in different case study regions and archives). The project bridges historiographic gaps between the Indian Ocean and Indonesian archipelago (‘East’) and Atlantic (‘West’). It revisits our understanding of slavery by innovating debates on: i) the global context of nationalized narratives of slavery history, ii) the impact of enslavement in relation to different slavery regimes, and iii) the ‘uniqueness’ of Atlantic slavery and racialization.

Mots-clés : slavery enslavement indian ocean atlantic
Projet ERC : YOUTHCLIMATEJUSTICE (Horizon Europe, appel 2022, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : University College Cork — Pays : Irlande — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1998870.0 €

YOUTHCLIMATEJUSTICE is the first large-scale transnational examination of youth justice in the climate crisis. In climate activism/litigation, under-18s are often leading on a political issue on a global scale – this is unprecedented in human rights law. Yet most children’s rights literature examines children as victims in the climate crisis. We know from other areas of law (e.g. family, criminal etc.) that justice processes are ill-suited to children, and have to be tailored to their needs. A body of work on ‘child-friendly justice’ has arisen to deal with this. YOUTHCLIMATEJUSTICE examines how child-friendly justice, and consequently children’s rights scholarship, is transformed by youth climate activism. The project proposes the ‘post-paternalism’ hypothesis – traditionally it is assumed that children are ‘given’ rights by adults such as the right to be heard, but youth climate activists are taking control of their own rights, e.g. in justice systems. YOUTHCLIMATEJUSTICE aims to work beyond contemporary paternalistic approaches to the UN Convention on the Rights of the Child; examining intergenerational dynamics in this ‘post-paternalist’ climate context. This will be done through three work packages examining youth climate justice in: 1.judgments 2.litigation and 3.participation. This transdisciplinary project will include innovative methodology including IDEAL causal modelling of case law data; surveys; and participatory action research (in Barbados, Canada, Ireland, Nepal, and South Africa) to theorise transformation in children’s rights through youth climate action. It is a groundbreaking democratic endeavour whereby children can shape both academia and human rights for a post-paternalist world. Outputs include a new evidence-informed framework on Child-Friendly Climate Justice [CFCJ]; to facilitate both academic and legal/social transformation in the field, a CFCJ Research Centre, and an experimental initiative to embed CFCJ in a live climate case.

Mots-clés : children s rights human rights law child friendly justice climate crisis litigation
Projet ERC : LIVE (Horizon Europe, appel 2022, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Physical and Analytical Chemical Sciences
Entité participante : Université de Technologie de Kaiserslautern — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : TUK
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 924375.0 €

A biological system’s phenotype and the evolution thereof are mirrored in molecular composition. The complexity of biological samples, however, renders quantitative, multivariate molecular probing challenging, in particular for non-destructive, label-free approaches. Vibrational spectroscopies capture signals from all molecular bonds exchanging energy with an optical excitation, delivering highly-specific optical fingerprints of samples in their native state, to which virtually all molecules contribute. Yet, while infrared (IR) spectroscopies profit from large vibrational cross-sections, technical limitations of IR radiation sources and detection have so far limited their applicability to real-world biomedical settings, in particular in the context of highly absorbing water (ubiquitous in biological samples). The project LIVE aims at harnessing the unparalleled control over light, on the level of individual optical-field oscillations, afforded by femtosecond lasers and nonlinear optics, to overcome current technological limitations and advance IR spectroscopy toward the fundamental limits set by the nature of light and, thus, toward the ultimate sensitivity, specificity and throughput achievable in optical vibrational fingerprinting. To this end, we envisage the development of powerful sources of fewcycle pulses covering the entire IR molecular fingerprint region (500–4000 cm-1) with utmost electric-field waveform stability, and of innovative electric-field sampling techniques capturing nearly all photons emitted by linearly and nonlinearly excited molecular vibrations. The host institution permits immediate validation of these developments for real-world biomedical samples, including, high-throughput vibrational fingerprinting of individual cells in flow cytometry, spectral tissue histopathology and high-resolution, high-sensitivity breath gas monitoring. Thus, LIVE promises direct impact on patients’ health, deeply rooted in basic photonics research.

Mots-clés : infrared spectroscopy advanced laser physics biomedical optics femtosecond lasers
Projet ERC : DEXES (Horizon Europe, appel 2022, Consolidator grants)
Domaine scientifique : Life Science
Panel : Immunity, Infection and I mmunotherapy
Entité participante : Institut Pasteur — Pays : France — Rôle : Partner
Type d'entité : Recherche
Financement ERC de l'entité : 100000.0 €

Malaria remains a devastating public health burden – the estimated death toll in 2020 was over 600,000. Its eradication is a desirable goal; however, the development of novel intervention strategies is hampered by limited current understanding of the biology of Plasmodium, the causative agent of malaria, and of its complex interactions with mammalian and mosquito hosts. In the liver, inside hepatocytes, Plasmodium parasites can either 1) replicate, forming new parasites that will infect erythrocytes and cause disease, or 2) remain dormant, which can lead to chronic, relapsing disease weeks to years after the original infection. I recently discovered new hepatic outcomes using a novel pipeline for single-cell hepatocyte-pathogen sequencing. I have identified sub-populations of sexually committed parasite forms, previously thought to appear only during erythrocytic infection. This groundbreaking insight into the Plasmodium life cycle can change our understanding of malaria transmission, yet it remains unknown how malaria parasites commit to these different developmental outcomes in hepatocytes. DEXES will test the hypothesis that Plasmodium liver infection outcomes depend upon the metabolic state of the host hepatocyte. Using engineered human microlivers, new humanized mouse models, trans-species studies and single-cell technologies, I will: 1) identify parasite-encoded molecular mechanisms implicated in the induction and maintenance of dormancy, activation, and sexual conversion in the liver, and 2) establish the bidirectional relationships between host metabolism and distinct parasite cell fates and their impact on treatment outcomes. This project will uncover the molecular mechanisms underpinning dormancy, relapsing and transmission of malaria parasites, and lay the groundwork for the future development of new therapies targeting the liver infection reservoirs.

Mots-clés : malaria,plasmodium,plasmodium vivax,hypnozoites,dormancy,relapse,sexual commitment,transmission,single cell,transcriptomics,host parasite interactions,metabolism,liver,hepatocytes,gametocytes
Projet ERC : GPWILD (Horizon Europe, appel 2024, Consolidator grants)
Domaine scientifique : Life Science
Panel : Environmental B iology, Ecology  and E volution
Entité participante : Université norvégienne de sciences et de technologie — Pays : Norvège — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1704982.0 €

In order to halt the ongoing biodiversity loss, we need a radically better understanding of key evolutionary and ecological processes of wild populations. The revolutionary methods of my project will enable us to utilize the rapidly-increasing volumes of high-density genomic data for wild populations, and open up unseen opportunities for genomic modeling of eco-evolutionary processes in wild systems. As a result, we will gain an improved understanding of why some species can cope better with the expected global changes of the environment than others. My three major objectives are to: (1) develop a broad set of tools for effcient and accurate prediction of evolutionary change and adaptive evolutionary potential in spatially and temporally structured populations, (2) provide a general theoretical foundation for the developments of new methods to estimate accuracy in important parameters of eco-evolutionary dynamics, and (3) quantify key processes affecting eco-evolutionary dynamics in six exceptional wild long-term study systems by applying the proposed methods. I will do so by developing cutting-edge statistical methodology that builds on the current state-of-the art in animal breeding, human genomics, ecology and evolutionary biology. As an innovative statistician with cross-disciplinary expertise and long collaborations with biologists, I am uniquely positioned for this task. All methods will be developed and tested around the six empirical data sets, as well as via extensive simulation studies that allow us to experiment with scenarios similar to those expected to be available in the near future. My work will expand current research boundaries, both in terms of methods and theory, and has a wide range of possible applications far beyond the data at hand, which will spark additional research. Most importantly, the project will create valuable new insight into adaptive evolutionary processes and how to best preserve the Earth's biological diversity.

Mots-clés : genomic data,genomic prediction,biodiversity conservation,egological statistics,bayesian statistics,adaptive potential
Projet ERC : OpenQuantum (Horizon Europe, appel 2024, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Physical and Analytical Chemical Sciences
Entité participante : Université norvégienne de sciences et de technologie — Pays : Norvège — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1996840.0 €

To control chemistry we must understand it, and this requires a fundamental quantum mechanical description. Today we have a highly mature state of accurate quantum chemical modeling of molecules. A central assumption in these models is that the molecules have a fixed number of electrons, i.e., that they are electronically closed. Recent experiments show great promise for probing chemical understanding and inducing chemical reactivity by passing a current of electrons through the molecule. Hence, quantum chemical models which can treat molecules as electronically open quantum systems are urgently needed. The mission of OpenQuantum is to establish the field of electronic wave function theory for electronically open systems. I will establish high-level models within the open quantum system formalism and develop it into a validated computational toolbox. Computationally efficient and versatile wave function implementations connected to multiscale environment models provide tools for investigating ground and excited state properties under open conditions. I will provide a detailed theoretical and computational description of how molecules are modified through electric currents, and explore possibilities that emerge in chemistry through fundamental knowledge of molecules as open quantum systems. The new methodologies and insight that OpenQuantum will bring are crucial to push the underlying understanding of excited states and redox stability of open molecules toward the use of electric current to catalyze and modify chemical reactions.
Projet ERC : Liquid3D (Horizon Europe, appel 2021, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Materials Engineering
Entité participante : Université de Coimbra — Pays : Portugal — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2570315.0 €

Liquid3D proposes bioinspired electronics and machines that are soft, resilient, self-healing, shape-morphing, and fully recyclable. Functional sensing/acting/processing/energy cells will be 3D printed using a series of game changer Liquid Metal based composites. As a result, we will print futuristic soft electronics that sense and interact with humans or the environment. This provides an excellent design freedom to scientists for manufacturing complex “living” electronics, while guaranteeing that any possible product coming from these inventions will be Resilient, Repairable, and Recyclable. I expect that over 80% of microchips, and metals in the printed circuits, can be recovered. Liquid3D redefines the electronics, by rethinking the materials, fabrications, and design architectures. These objectives are feasible, thanks to the recent breakthroughs that I made to the field: First; discovery of the biphasic (liquid-solid) composite based on Gallium-Indium Liquid Metal (LM), that allowed the first ever method for room temperature printing of stretchable circuits; and second, a method for inclusion of microelectronics into ultra-stretchable circuits through self-soldering, self-healing, and self-encapsulating of LM-Polymer composites. With Liquid3D I will develop fundamental understanding, and mathematical modelling of biphasic systems, and develops novel room temperature printable composites with sensing/acting/energy storage properties, and methods for recycling them. I will investigate novel forms of implementing truly 3D electronics, with distributed functional cells. Liquid3D intends to fundamentally rethink, the concept of electronics, as we know today. From rigid and brittle to soft, resilient and repairable; From polluting to recyclable; from battery dependent to self-powered; from 2D to truly 3D; It proposes a radically new way of making “greener” electronics. With Liquid3D I aim to establish the world leading centre on recyclable, and green electronics.

Mots-clés : additive manufacturing,recyclable electronics,bioinspiration,liquid metal,stretchable electronics,robotics,graphene,printed electronics