Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : CancerADAPT (Horizon 2020, appel 2018, Consolidator grants)
Domaine scientifique : Life Science
Panel : Physiology in Health, Disease and Ageing
Entité participante : CIC bioGUNE — Pays : Espagne — Rôle : PI
Type d'entité : Recherche
Financement ERC de l'entité : 1999882.0 €

The composition and molecular features of tumours vary during the course of the disease, and the selection pressure imposed by the environment is a central component in this process. Evolutionary principles have been exploited to explain the genomic aberrations in cancer. However, the phenotypic changes underlying disease progression remain poorly understood. In the past years, I have contributed to identify and characterise the therapeutic implications underlying metabolic alterations that are intrinsic to primary tumours or metastasis. In CancerADAPT I postulate that cancer cells rely on adaptive transcriptional & metabolic mechanisms [converging on a Metabolic Phenotype] in order to rapidly succeed in their establishment in new microenvironments along disease progression. I aim to predict the molecular cues that govern the adaptive properties in prostate cancer (PCa), one of the most commonly diagnosed cancers in men and an important source of cancer-related deaths. I will exploit single cell RNASeq, spatial transcriptomics and multiregional OMICs in order to identify the transcriptional and metabolic diversity within tumours and along disease progression. I will complement experimental strategies with computational analyses that identify and classify the predicted adaptation strategies of PCa cells in response to variations in the tumour microenvironment. Metabolic phenotypes postulated to sustain PCa adaptability will be functionally and mechanistically deconstructed. We will identify therapeutic strategies emanating from these results through in silico methodologies and small molecule high-throughput screening, and evaluate their potential to hamper the adaptability of tumour cells in vitro and in vivo, in two specific aspects: metastasis and therapy response. CancerADAPT will generate fundamental understanding on how cancer cells adapt in our organism, in turn leading to therapeutic strategies that increase the efficacy of current treatments.

Mots-clés : cancer cell adaptability,therapeutic vulnerabilities,molecular basis for cancer progression,prostate cancer,transcriptional and metabolic programs in tumours
Projet ERC : SUPERMEM (Horizon 2020, appel 2020, Proof of concept grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Centre national de la recherche scientifique — Pays : France — Rôle : PI
Acronyme de l'entité : CNRS
Type d'entité : Recherche
Financement ERC de l'entité : 145000.0 €

The concept we aim a proving is a novel type of electronic device, a redox superconducting memristor, whose functionality is beyond that of binary memories: it shows a continuum of states (instead of just two), and the switching between them can be driven by a sequence of voltage pulses or by visible light illumination. Furthermore, it is based on high-temperature superconductors, allowing for low-dissipation devices. This concept stems from recent work in the frame of an ERC consolidator grant, which has demonstrated the physical mechanism that produces the memristive behavior: a controlled red-ox reaction. The structural simplicity of the proposed memristor radically improves scalability and facilitates fabrication as compared to the existing approaches. The new functionalities it brings, particularly photosensitivity and the superconductivity, open new avenues in the areas of application, which include neuromorphic computing and superconducting electronics.

Mots-clés : high tc superconductors,memristors,oxide interfaces,redox
Projet ERC : DISCOMPOSE (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Naples Federico II — Pays : Italie — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1481813.0 €

The connections between the circulation of news of extreme events, the making of influential narratives of collective traumas and the development of emergency response policies lie at the heart of this research proposal, which focuses on four Southern European areas: Catalonia, Naples, Sicily and Valencia, from the 16th to the 18th century. How did accounts and individual memories of extreme events amount to authoritative interpretations? In which ways, and to what extent, did the latter orient collective behaviours and the recovery process, in both the short and the long term? Starting from the assumption that human relations are enhanced by the increased levels of socialisation that commonly occur in the aftermath of shocking events, which trigger the sharing of information, opinions and memories; and that the emotional impact of such events is likely to create a public opinion that draws attention to government’s action; the research proposal aims to contribute new insights into these issues by adopting an original methodology, developed across a variety of disciplines, including Cultural and Social History, Textual Criticism, Philology and Anthropology. Moreover, it will adopt a transnational perspective: since the selected regions belonged to the Spanish Monarchy, the development of practices and polices aimed to respond to disruption depended not only on the specific social and cultural features of local societies, but also on the circulation of political and technical staff, as well as on the sharing of knowledge, experiences and policy models, among the various areas of the Empire and its colonies. Studying the information exchange in the aftermath of disasters and the formation of an imagery of extraordinary events, will allow a comprehensive perspective on the policies and practices adopted by early modern societies to manage uncertainty, and on the potential impact that such narratives could have on the renegotiation of political and social relations.

Mots-clés : disaster studies,information exchange,transnational circulations,political communication,post disaster recovery
Projet ERC : NEMUS (Horizon 2020, appel 2020, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : University of Edinburgh — Pays : Royaume-Uni — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

The conservation, restoration and maintenance of rare and precious musical instruments is currently problematic, and will become increasingly so in the future: most instruments in museum collections are already out of playing condition, and deteriorating to the extent that their unique sounds will eventually be lost. Curators are well aware of the ethical problems associated with restoration and maintenance, and digital technology offers a solution to the problem of saving the sound of historical musical instruments. However, current digitisation practices are largely inadequate for a deeper understanding of musical instruments, as they have so far been limited to photogrammetric or sampling techniques. The applicant believes that museum collections would benefit from a new approach to digitising musical instruments. A comprehensive understanding of musical instruments can only be achieved by a focused acoustical and mathematical study, ultimately yielding a wealth of efficient and realistic simulation techniques which could be used for real-time emulation: this is the context in which NEMUS will operate. By developing the most advanced mathematical models yet describing sound propagation and transmission in musical instruments, NEMUS will create sustainable, durable and realistic digital emulations of historical musical instruments that are currently out of playing condition. NEMUS will also generate computer-aided simulation studies of a number of harpsichords of the Ruckers/Couchet tradition, to complement organological studies on Ioseph Ioannes Couchet craftmanship. For the first time, complex musical systems will be solved under real-time, on standard consumer hardware, using mainstream numerical methods such as finite difference schemes, including the player’s interaction with the instrument. Appropriate controllers with haptic feedback will be devised, so as to facilitate use in virtual and augmented reality environments.
Projet ERC : CRISPR2.0 (Horizon 2020, appel 2018, Consolidator grants)
Domaine scientifique : Life Science
Panel : Molecules of Life: Biological Mechanisms, Structures and Functions
Entité participante : University of Zurich — Pays : Suisse — Rôle : PI
Acronyme de l'entité : UZH
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1996525.0 €

The constant arms race between prokaryotic microbes and their molecular parasites such as viruses, plasmids and transposons has driven the evolution of complex genome defence mechanisms. The CRISPR-Cas defence systems provide adaptive RNA-guided immunity against invasive nucleic acid elements. CRISPR-associated effector nucleases such as Cas9, Cas12a and Cas13 have emerged as powerful tools for precision genome editing, gene expression control and nucleic acid detection. However, these technologies suffer from drawbacks that limit their efficacy and versatility, necessitating the search for additional exploitable molecular activities. Building on our recent structural and biochemical studies, the goal of this project is to investigate the molecular architectures and mechanisms of CRISPR-associated systems and other genome defence mechanisms, aiming not only to shed light on their biological roles but also inform their technological development. Specifically, the proposed studies will examine (i) the molecular basis of cyclic oligoadenylate signalling in type III CRISPR-Cas systems, (ii) the mechanism of transposon-associated type I CRISPR-Cas systems and their putative function in RNA-guided DNA transposition, and (iii) molecular activities associated with recently described non-CRISPR defence systems. Collectively, the proposed studies will advance our understanding of the molecular functions of genome defence mechanisms in shaping the evolution of prokaryotic genomes and make critical contributions to their development as novel genetic engineering tools.

Mots-clés : crispr cas,transposons,nucleases,dna helicases,genome editing
Projet ERC : Browsec (Horizon 2020, appel 2017, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Computer science and informatics
Entité participante : TU Wien — Pays : Autriche — Rôle : PI
Acronyme de l'entité : TUW
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1785000.0 €

The constantly increasing number of attacks on web applications shows how their rapid development has not been accompanied by adequate security foundations and demonstrates the lack of solid security enforcement tools. Indeed, web applications expose a gigantic attack surface, which hinders a rigorous understanding and enforcement of security properties. Hence, despite the worthwhile efforts to design secure web applications, users for a while will be confronted with vulnerable, or maliciously crafted, code. Unfortunately, end users have no way at present to reliably protect themselves from malicious applications. BROWSEC will develop a holistic approach to client-side web security, laying its theoretical foundations and developing innovative security enforcement technologies. In particular, BROWSEC will deliver the first client-side tool to secure web applications that is practical, in that it is implemented as an extension and can thus be easily deployed at large, and also provably sound, i.e., backed up by machine-checked proofs that the tool provides end users with the required security guarantees. At the core of the proposal lies a novel monitoring technique, which treats the browser as a blackbox and intercepts its inputs and outputs in order to prevent dangerous information flows. With this lightweight monitoring approach, we aim at enforcing strong security properties without requiring any expensive and, given the dynamic nature of web applications, statically infeasible program analysis. BROWSEC is thus a multidisciplinary research effort, promising practical impact and delivering breakthrough advancements in various disciplines, such as web security, JavaScript semantics, software engineering, and program verification.

Mots-clés : web security,formal methods,program verification
Projet ERC : MILESTONE (Horizon 2020, appel 2018, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Earth system science
Entité participante : Centre national de la recherche scientifique — Pays : France — Rôle : PI
Acronyme de l'entité : CNRS
Type d'entité : Recherche
Financement ERC de l'entité : 1999500.0 €

The continental crust is the principal record of conditions on Earth during the past 4.4 billion years, yet how it formed and evolved through time remains unresolved. Zircon lies at the core of crustal evolution studies, and yet our knowledge has remained restricted to the geochemical information that can be extracted from this mineral with current techniques. This CoG moves the debate to a different scale analytically, to the scale of mineral inclusions encapsulated within zircons. A key motivation is the recent analytical breakthrough in the microanalysis of minute samples, which was achieved by the PI and the team he led at the University of Bristol, using state-of-the-art instruments similar to those now available at the PI’s host laboratory. The integrated analysis of Sr and Pb isotopes of mineral inclusions, along with the trace elements, U-Pb, Hf and O isotopes analysis of their host zircons, for over 5000 zircons of different ages and provenance, will provide new and different information to that available from the 'zircon only' record – ultimately to i) probe the inferred transition from intraplate- to subduction-related magmatism associated with the onset of plate tectonics; ii) date this transition and its duration precisely in different places; iii) develop a global model of continental crust evolution from the Hadean (i.e. >4 Ga) to the Present, in which the Earth has progressively, or more suddenly, become a habitable planet. These goals will be achieved through: 1. Building a worldwide collection of inclusion-bearing zircons with a range of ages and provenance (WP1). 2. Evaluating changes in the degree of differentiation of the newly generated continental crust through time, using the Sr isotope record of apatite inclusions (WP2). 3. Addressing changes in the tectonic settings of new crust formation, using the Pb isotope record of feldspar inclusions (WP3). 4. Modelling the variation in the new crust thickness through space and time (WP4).

Mots-clés : continental crust evolution,plate tectonics,hadean,archaean,early earth,zircon,mineral inclusions,laser ablation,mass spectrometry
Projet ERC : NORVAS (Horizon 2020, appel 2015, Starting grants)
Domaine scientifique : Life Science
Panel : Prevention, Diagnosis and Treatment of Human Diseases
Entité participante : Technical University of Munich — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : TUM
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

The contribution of cardiovascular disease to human morbidity and mortality continues to steadily increase in our aging European society. In response, extraordinary efforts have been launched to determine the molecular and pathophysiological characteristics of its etiology. The collective work of multiple research groups has uncovered a complex transcriptional and post-transcriptional regulatory milieu, which is believed to be essential for maintaining cardiovascular homeostasis. Recently, non-coding RNAs, especially the ones with antisense capabilities such as microRNAs or ‘natural antisense transcripts’ (NATs) have received much attention. They have been identified as important transcriptional and post-transcriptional inhibitors of gene expression. This current proposal describes the development of novel diagnostic and therapeutic strategies to limit the burden of cardiovascular disease in general, and abdominal aortic aneurysms as well as carotid stenosis and subsequent stroke in particular. Using transcriptomic profiling techniques on human diseased tissue samples, we have identified two NATs (SLFNL-AS1 and NUDT6) as novel crucial regulators of smooth muscle cell survival via targeting CTPS1 and the fibroblast growth factor 2 (FGF2) in the vascular system. We are using disease-relevant experimental in vivo models (rodents and LDLR-/- mini-pigs) to functionally assess how inhibition of these two NATs influences aneurysm progression and atherosclerotic plaque vulnerability. One focus of our studies is to utilize local delivery mechanisms for non-coding RNA modulators, such as drug eluting balloons and stents, to enhance the translational feasibility of our findings. Furthermore, we have access to unique human plasma material from patients with early and advanced forms of aneurysm disease, enabling us to investigate the biomarker value of non-coding RNAs in recognizing patients with acutely ruptured aneurysms, as well as predicting the future risk of rupture.

Mots-clés : non coding rna,microrna,abdominal aortic aneurysm,stroke
Projet ERC : BrainInBrain (Horizon 2020, appel 2016, Starting grants)
Domaine scientifique : Life Science
Panel : Neuroscience and Disorders of the Nervous System
Entité participante : Lund University — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1500000.0 €

The core function of all brains is to compute the current state of the world, compare it to the desired state of the world and select motor programs that drive behavior minimizing any mismatch. The circuits underlying these functions are the key to understand brains in general, but so far they are completely unknown. Three problems have hindered progress: 1) The animal’s desired state of the world is rarely known. 2) Most studies in simple models have focused on sensory driven, reflex-like processes, and not considered self-initiated behavior. 3) The circuits underlying complex behaviors in vertebrates are widely distributed, containing millions of neurons. With this proposal I aim at overcoming these problems using insects, whose tiny brains solve the same basic problems as our brains but with 100,000 times fewer cells. Moreover, the central complex, a single conserved brain region consisting of only a few thousand neurons, is crucial for sensory integration, motor control and state-dependent modulation, essentially being a ‘brain in the brain’. To simplify the problem further I will focus on navigation behavior. Here, the desired and actual states of the world are equal to the desired and current headings of the animal, with mismatches resulting in compensatory steering. I have previously shown how the central complex encodes the animal’s current heading. Now I will use behavioral training to generate animals with highly defined desired headings, and correlate neural activity with the animal’s ‘intentions’ and actions - at the level of identified neurons. To establish the involved conserved core circuitry valid across insects I will compare species with distinct lifestyles. Secondly, I will reveal how these circuits have evolved to account for each species’ unique ecology. The proposed work will provide a coherent framework to study key concepts of fundamental brain functions in unprecedented detail - using a single, conserved, but flexible neural circuit.

Mots-clés : central complex,internal compass,navigation,sensory motor transformation,behavior,circuits
Projet ERC : BIOSEC (Horizon 2020, appel 2015, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Social World and Its Diversity
Entité participante : University of Sheffield — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1822729.0 €

The core intellectual aim of BIOSEC is to explore whether concerns about biodiversity protection and global security are becoming integrated, and if so, in what ways. It will do so via building new theoretical approaches for political ecology. Achim Steiner, UN Under-Secretary General and Executive Director of UNEP recently stated ‘the scale and role of wildlife and forest crime in threat finance calls for much wider policy attention’. The argument that wildlife trafficking constitutes a significant source of ‘threat finance’ takes two forms: first as a lucrative business for organised crime networks in Europe and Asia, and second as a source of finance for militias and terrorist networks, most notably Al Shabaab, Lord’s Resistance Army and Janjaweed. BIOSEC is a four year project designed to lead debates on these emerging challenges. It will build pioneering theoretical approaches and generate new empirical data. BIOSEC takes a fully integrated approach: it will produce a better conceptual understanding of the role of illegal wildlife trade in generating threat finance; it will examine the links between source and end user countries for wildlife products; and it will investigate and analyse the emerging responses of NGOs, government agencies and international organisations to these challenges. BIOSEC goes beyond the ‘state-of-the art’ because biodiversity protection and global security currently inhabit distinctive intellectual ‘silos’; however, they need to be analysed via an interdisciplinary research agenda that cuts across human geography, politics and international relations, criminology and conservation biology. This research is timely because in the last two years, the idea that the illegal wildlife trade constitutes a major security threat has become more prevalent in academic and policy circles, yet it is an area that is under researched and poorly understood. These recent shifts demand urgent conceptual and empirical interrogation.

Mots-clés : political ecology,illegal wildlife trade,biodiversity conservation,security