Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : BRCA-ERC (Horizon 2020, appel 2016, Advanced grants)
Domaine scientifique : Life Science
Panel : Integrative Biology: from Genes and Genomes to Systems
Entité participante : University College London Hospitals NHS Foundation Trust — Pays : Royaume-Uni — Rôle : Partner
Acronyme de l'entité : UCLH
Type d'entité : Recherche
Financement ERC de l'entité : 233251.25 €

Recent evidence demonstrates that cancer is overtaking cardiovascular disease as the number one cause of mortality in Europe. This is largely due to the lack of preventative measures for common (e.g. breast) or highly fatal (e.g. ovarian) human cancers. Most cancers are multifactorial in origin. The core hypothesis of this research programme is that the extremely high risk of BRCA1/2 germline mutation carriers to develop breast and ovarian cancer is a net consequence of cell-autonomous (direct effect of BRCA mutation in cells at risk) and cell non-autonomous (produced in distant organs and affecting organs at risk) factors which both trigger epigenetic, cancer-initiating effects. The project’s aims are centered around the principles of systems medicine and built on a large cohort of BRCA mutation carriers and controls who will be offered newly established cancer screening programmes. We will uncover how ‘cell non-autonomous’ factors work, provide detail on the epigenetic changes in at-risk tissues and investigate whether these changes are mechanistically linked to cancer, study whether we can neutralise this process and measure success in the organs at risk, and ideally in easy to access samples such as blood, buccal and cervical cells. In my Department for Women’s Cancer we have assembled a powerful interdisciplinary team including computational biologists, functionalists, immunologists and clinician scientists linked to leading patient advocacy groups which is extremely well placed to lead this pioneering project to develop the fundamental understanding of cancer development in women with BRCA mutations. To reset the epigenome, re-establishing normal cell identity and consequently reducing cancer risk without the need for surgery and being able to monitor the efficacy using multicellular epigenetic outcome predictors will be a major scientific and medical breakthrough and possibly applicable to other chronic diseases.

Mots-clés : cancer and its biological basis,women s cancers,breast cancer,ovarian cancer,brca1,2 mutation,cell non autonomous,hormones,prevention,early diagnosis,surrogate markers
Projet ERC : reFUEL (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : University of Natural Resources and Life Sciences, Vienna — Pays : Autriche — Rôle : PI
Acronyme de l'entité : BOKU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499905.0 €

Recent global integrated modelling studies indicate low intensities in trade of energy commodities between global regions in a future low-carbon global energy system. Also, research based on modelling indicates that deep greenhouse-gas emission cuts are possible in fully electrified renewable energy systems on a continental or country scale from a techno-economic perspective. However, these modelling efforts partly neglect drivers of globalization and may therefore wrongly project regionalization of energy systems. In particular, (i) new, easily tradable, low-cost renewable fuels (e.g. solar & electric fuels), (ii) global bio-physical variability of renewables (e.g. solar radiation and freshwater availability), and (iii) regional differences in social land-use restrictions associated with the expansion of energy infrastructure can cause an increase of trade flows in the energy sector. We aim at better understanding how the spatial configuration of renewables in low-carbon energy systems is affected by these drivers and develop a cutting-edge, open-source global renewable energy model that combines elements of energy system and land-use modelling. It takes into account bio-physical conditions for renewable fuel and electricity production, social land availability restrictions, and a map of existing energy infrastructure at unprecedented level of detail. Our approach integrates open data sources from public institutions, user-generated GIS data, and social networks. Existing models for Europe and Brazil are used for validation. Qualitative interviews in local case studies complement the global model and increase our understanding of land-use restrictions on the local scale. Our project has impacts beyond energy systems analysis: in particular the identification of winning and losing regions in a global renewable energy system is highly relevant in climate change mitigation negotiations, and the generated spatial indicators and maps enable many potential applications.

Mots-clés : energy system analysis,solar fuels,qualitative validation,renewable energies,trade
Projet ERC : ReligSpace (Horizon 2020, appel 2018, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Social World and Its Diversity
Entité participante : Hebrew University of Jerusalem — Pays : Israël — Rôle : PI
Acronyme de l'entité : HUJI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499625.0 €

Recent globalization and immigration trends are motivating tremendous efforts to regulate manifestations of minority religions in the public space, such as religious structures, stores, attire, and rituals (hereafter, spatial religious manifestations). Yet the empirical literature has, to date, not taken on the methodologically and conceptually challenging undertaking of theorizing, operationalizing, and assessing this dimension of religion. In particular, it remains unclear what causal effect manifestations of religion in the public space have on minority-religion immigrants’ sociopolitical integration: do they, by validating immigrants’ identity, facilitate a sense of belonging and the endorsement of local practices, or nurture alienation and hostility toward the host society? Integrating up-to-date theories and methods from political science, psychology, sociology, and geography, and optimizing external and internal validity, this project is the first large-scale research to examine the causal effect of exposure to spatial religious cues on sociopolitical integration, studying minority-religion immigrants of the three monotheistic religions in four urban settings. The research will be divided into three work packages: (1) conceptualization and operationalization of spatial religious manifestations; (2) comparative naturalistic and survey-embedded experiments examining the effect of real-world spatial religious cues on minority-religion immigrants’ sociopolitical integration; and (3) a panel survey with longitudinal geocoded data analyzing the conditions in which spatial religious cues are particularly instrumental in local-level integration. Besides developing a novel approach to the study of religion in politics, this project will open new horizons in the understanding of aggregated religious priming effects in real-world settings, with insights into the dynamics that would advance a more inclusive society via nuanced policies and informed urban planning.
Projet ERC : theranoimmuno (Horizon 2020, appel 2020, Starting grants)
Domaine scientifique : Life Science
Panel : Biotechnology and Biosystems Engineering
Entité participante : Institut de cancérologie Strasbourg Europe — Pays : France — Rôle : PI
Acronyme de l'entité : ICANS
Type d'entité : Recherche
Financement ERC de l'entité : 890357.0 €

Recent studies on the developments of immune mobilizing monoclonal T-cell receptors against cancer (ImmTAC), bispecific T-cell receptors (TCR) engagers, and chimeric antigen receptor (CAR) cell-based therapies, have highlighted their potential to treat Multiple Myeloma (MM). These treatments, however, are expensive. The manufacturing processes that are employed for their generation are lengthy, and their commercial scale production is reliant on a multitude of equipment and operators that cannot easily be incorporated in the footprint of most local hospitals. Moreover, patient responses to these treatments remain heterogenous. We propose an innovative multidisciplinary approach that aims to develop a novel theranostic immune-cell based compound. This approach is based on the functionalization of the immune cells with theranostic ultrasmall macromolecules (USM); USM having a diameter size below 10 nm to allow renal clearance and minimize toxicity. The clinically-relevant imaging properties of the USM will allow to unveil various challenges remaining in the field of immunotherapy, such as to better elucidate the priming sites of immune cells, to track their migration in the body, as well as to localize their niche upon the establishment of minimal residual disease. By labelling the immune cells ex vivo, the diagnostic imaging properties enabled by the presence of the USM on the immune cell surface will allow to generate better ex vivo immune cells therapeutics (such as simili-CAR NK cells) with a rationalized target selection, will improve the cell dosing, and will help to better stratify the patient population in order to offer an improved personalized treatment plan.
Projet ERC : AdOMiS (Horizon 2020, appel 2015, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Systems and communication engineering
Entité participante : University of Oxford — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 3234789.0 €

Recent technological advances in optical microscopy have vastly broadened the possibilities for applications in the biomedical sciences. Fluorescence microscopy is the central tool for investigation of molecular structures and dynamics that take place in the cellular and tissue environment. Coupled with progress in labeling methods, these microscopes permit observation of biological structures and processes with unprecedented sensitivity and resolution. This work has been enabled by the engineering development of diverse optical systems that provide different capabilities for the imaging toolkit. All such methods rely upon high fidelity optics to provide optimal resolution and efficiency, but they all suffer from aberrations caused by refractive index variations within the specimen. It is widely accepted that in many applications this fundamental problem prevents optimum operation and limits capability. Adaptive optics (AO) has been introduced to overcome these limitations by correcting aberrations and a range of demonstrations has shown clearly its potential. Indeed, it shows great promise to improve virtually all types of research or commercial microscopes, but significant challenges must still be met before AO can be widely implemented in routine imaging. Current advances are being made through development of bespoke AO solutions to individual imaging tasks. However, the diversity of microscopy methods means that individual solutions are often not translatable to other systems. This proposal is directed towards the creation of theoretical and practical frameworks that tie together AO concepts and provide a suite of scientific tools with broad application. This will be achieved through a systems approach that encompasses theoretical modelling, optical engineering and the requirements of biological applications. Additional outputs will include practical designs, operating protocols and software algorithms that will support next generation AO microscope systems.

Mots-clés : optical systems engineering,adaptive optics,biomedical microscopy
Projet ERC : HRNUDGE (Horizon 2020, appel 2018, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : University of London — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : U. London
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 517550.76 €

Recent years have seen a renewed interest in the effectiveness of human rights law and judgments, yet almost no attention has been given to the impact of remedies on states’ compliance practices or the internalisation of human rights into their domestic legal systems. Through a combination of quantitative and qualitative research in six countries, the project aims to expose the dynamics of the (non)compliant state and the efficacy of different types of remedies in changing the behaviour of human rights violators. These goals will be achieved through three sub-studies: (1) an empirical study of the case law of the European Court of Human Rights (ECtHR) to determine the compliance and internalisation practices and their link to different remedies; (2) the exploration and analysis of states’ internalisation practices and policies (including the identification of players that shape this practice) to determine whether remedies play a crucial role in shifting states’ actions; (3) a computer simulation to discover how we can change the architecture of human rights remedies to increase compliance and internalisation, and to deter future violations. The central aim of the project is to identify new remedy options – incentives or nudges – which human rights institutions can use to deter future violations. Using the example of the ECtHR and its caselaw, the research will build on insights from behavioural economics to interrogate widespread assumptions about monetisation of human rights, public shaming, and deference shown to states in the specification of remedies. Through computer simulation, the project will aim to predict how monetary and non-monetary remedies could be used separately or together to alter the behaviour of states and their key players. The research will be ground-breaking in many ways, reshaping the field of human rights remedies and contributing crucially to the emerging field of behavioural international law.
Projet ERC : GPSART (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Mathematics
Entité participante : Forschungsverbund Berlin — Pays : Allemagne — Rôle : Partner
Acronyme de l'entité : FVB
Type d'entité : Recherche
Financement ERC de l'entité : 285000.0 €

Recent years have seen an explosion of applications of geometric and pathwise ideas in probability theory, with motivations from fields as diverse as quantitative finance, statistics, filtering, control theory and statistical physics. Much can be traced back to Bismut, Malliavin (1970s) on the one-hand and then Doss, Sussman (1970s), Foellmer (1980s) on the other hand, with substantial new input from Lyons (from '94 on), followed by a number of workers, including Gubinelli (from '04 on) and the writer of these lines (also from '04 on). Most recently, the theory of such ``rough paths" has been extended to ``rough fields", notably in the astounding works of M. Hairer (from '13 on). The purpose of this project is to study a number of important problems in this field, going beyond the rough path setting, and with emphasis on geometric ideas. (i) The transfer of concepts from rough path theory to the new world of Hairer's regularity structures. (ii) Applications of geometric and pathwise ideas in quantitative finance. (iii) Obtain a pathwise understanding of the geometry of Loewner evolution and more generally explore the use of rough path-inspired ideas in the world of Schramm-Loewner evolution. (iv) Investigate the role of geometry in the pathwise analysis of non-linear evolution equations.

Mots-clés : pathwise stochastic analysis
Projet ERC : COMPEN (Horizon 2020, appel 2014, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : University of Cambridge — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : U. Cambridge
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1964948.0 €

Recent years have seen renewed interest in the political economy of punishment, yet almost no attention has been given to the factors that translate socio-political arrangements into penal practices or the specific nature of imprisonment in different political-economic systems. Based on research in England & Wales and one Nordic nation, the project goals are to expose the dynamics of the penal state and the nature of penality in countries that are considered ‘exclusionary’ and ‘inclusionary’ respectively in their socio-economic and penal practices. These goals will be achieved through four comparative sub-projects: first, a study of penal policymaking and the ‘penal field’ (the players and processes that shape penal policy and practice); second, an exploration of the texture of imprisonment for women and sex offenders, groups presumed to experience inclusionary and exclusionary penal practices in distinctive ways; third, a study of how these prisoners experience entry into and exit from the system; fourth, a study of the ‘deep end’ imprisonment in both countries. A central aim is to interrogate widespread assumptions about the relative mildness/severity of penal practices in inclusionary and exclusionary nations. The research will employ an emerging framework that conceptualises the prison experience through notions of ‘depth’, ‘weight’, ‘tightness’ and ‘breadth’. It will foreground the roles of shame and guilt in shaping prisoners’ orientations, concepts that feature in theories of offending and reintegration, but are absent from the sociology of imprisonment. Through the concept of ‘penal consciousness’, the project will also explore the interaction between the punitive intentions of the state and prisoners’ perceptions of the purposes and legitimacy of their punishment. The research will be groundbreaking in several ways, reshaping the field of comparative penology, and linking macro issues of the penal state with the lived realities of the prison landings.

Mots-clés : imprisonment  comparative penology
Projet ERC : STEMMING-FROM-NERVE (Horizon 2020, appel 2014, Consolidator grants)
Domaine scientifique : Life Science
Panel : Cellular, Developmental and Regenerative Biology
Entité participante : Medical University of Vienna — Pays : Autriche — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1964338.0 €

Recently we discovered an entirely new phenomenon in developmental biology – targeted recruitment of stem cells from the pervasive peripheral nerves. For example, we demonstrated that majority of melanocytes – our pigment cells, are born from peripheral glial cells. To further extend this far-reaching principle we will use tooth development as a model. Current opinion holds that sensory innervation of the tooth has a minor or no role in making a structure of the tooth during development and adulthood. On the contrary, our preliminary data strongly suggest that sensory nerve contributes pulp cells and matrix-producing cells of odontoblast lineage to the growing tooth. Our hypothesis implies that nerve-associated glial cells can be recruited from the nerve by unknown molecules presented inside of the tooth environment, and that these recruited cells are capable of producing pulp cells and odontoblasts. WE PROPOSE TO ADDRESS THE ROLE OF A SENSORY NERVE AS A PROVIDER OF DENTAL STEM CELLS DURING THE DEVELOPMENT, ADULTHOOD AND REGENERATION. To experimentally address our hypothesis we developed innovative and powerful approaches: we will use advanced genetics tracing with multicolor reporters, completely novel unconventional individual cell transcriptome analysis, transgenic mice with cell type-specific modifications in signaling, microsurgery and grafting, and, finally, 3D-imaging of developing tooth structures. This project is interesting to a wide community of scientists because it addresses a novel function of peripheral nervous system which is contributing stem cells as building blocks to local tissues in development and regeneration. The MEDICAL IMPLICATION of this project will include better understanding of tooth regeneration providing new approaches to dentin recovery and tooth restoration following trauma.

Mots-clés : peripheral nerves,schwann cells precursors,multipotency,tooth development,cellular lineage,genetic tracing,control of differentiation
Projet ERC : Cell-Lasers (Horizon 2020, appel 2019, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed matter physics
Entité participante : Jožef Stefan Institute — Pays : Slovénie — Rôle : PI
Acronyme de l'entité : IJS
Type d'entité : Recherche
Financement ERC de l'entité : 1079020.0 €

Recently, micro-sized lasers have been integrated into biological systems including cells and tissues. Currently the most frequently used techniques to study complex processes in live cells employ fluorescent probes. However, fluorescent probes have several disadvantages including photobleaching, sensitivity to environmental factors, potential phototoxicity and broad emission spectrum, which limits their sensitivity, multiplexing ability and imaging capabilities in biological tissues. The transition from detecting laser emission from bio-integrated lasers instead of fluorescence represents a paradigm shift. Due to narrow emission linewidth, high coherence, large intensity and highly nonlinear output from lasers, they open huge opportunities in ultrasensitive sensing, spectral multiplexing and microscopy. The applicant has recently for the first time demonstrated a laser completely embedded inside a live human cell. However, to date it has only been demonstrated that laser light can be generated within the cell, but not how is the laser output coupled to the biophysical and biochemical processes inside cells. The goal of Cell-Lasers is to study these intimate interactions including forces acting within cells, properties of natural cavities in lipid droplets and the intracellular chemical environment. Since the spectral positions of laser lines do not change with propagation through scattering and absorbing media, the cell lasers will enable multiplexed sensing, tracking and localization of cells embedded deep inside tissues. In the long term Cell-Lasers aims to transform the bio-integrated lasers from being a pure scientific curiosity into powerful tool for the study of biophysical and biochemical processes taking place on a single cell level.

Mots-clés : lasers,microcavities,cells,biophotonics,imaging,chemical sensing,barcoding,force,measurement,lipid droplets