Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : HISUBMET (Horizon Europe, appel 2021, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Synthetic Chemistry and Materials
Entité participante : Fondation Jean-Marie Lehn — Pays : France — Rôle : PI
Type d'entité : Recherche
Financement ERC de l'entité : 365000.0 €

Tetrasubstituted olefins are key to drug discovery, and the ability to such entities is a compelling goal. Pioneering studies have led to a number of noteworthy advances by significant shortcomings remain. For example, it is especially challenging to access tetrasubstituted alkenes that contain four sizeable substituents or a F atom and/or a CF3 unit. Most protocols can only afford one of the possible isomers. Tetrasubstituted alkenes that contain multiple modifiable substituents are particularly attractive, because they can serve as diversification points that lead to a large assortment of desirable compounds. Olefin metathesis offers a strategically distinct, efficient, and stereodivergent route to such entities. Yet, there are only a few reported olefin metathesis reactions that generate a cyclic tetrasubstituted olefin that does not contain two methyl substituents at each carbon (i.e., no stereochemistry). A much smaller number (four cases) are RCM reactions that afford cyclic tetrasubstituted olefins with one modifiable C–Cl bond. All involve a Ru catalyst. However, olefin metathesis reactions that can generate poly-halogenated olefins cannot be effected with a Ru catalyst (rapid decomposition). Only a Mo or a W catalyst must be used, but such complexes do not exist. We will design a new class of pivoting Mo and W catalysts that can be used to promote efficient RCM and cross-metathesis (CM) reactions that generate a wide range of readily modifiable tetrasubstituted olefins. We will accomplish this by designing catalysts wherein the rotation of the imido and aryloxide ligands is synchronized, so that a proper binding pocket is made available. The expected products, which can serve as versatile diversification points, will contain 2-3 easily modifiable units. We will also design an entirely new class of cyclic Mo and W catalysts for CM between easily accessible trisubstituted alkenes and polyhalogenated alkenes. A unique feature of these catalysts is that intra

Mots-clés : stereoselective synthesis,stereoselective catalysis
Projet ERC : FIRE (Horizon Europe, appel 2023, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Systems and Communication Engineering
Entité participante : École polytechnique Chalmers — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2499828.0 €

The project will establish frontline semiconductor terahertz electronics for far-infrared space instruments by exploring and combining InP-based semiconductors with thin silicon membrane technology. The goal is to obtain high receiver sensitivity and stability for much less power consumption beyond what is currently considered state-of-the-art in the 2-5 THz frequency range. Terahertz measurements of the atmosphere are made routinely to monitor and reveal physical and chemical processes related to weather and climate change. New space initiatives, using constellations of terahertz receivers on small satellites, can help to gain further data and insights about the climate system. For atmosphere science, there is a need for a terahertz receiver without active cryogenic cooling that can operate over a broad ambient temperature range with sufficient sensitivity and can make observations over a long time. For the supra-terahertz band (>3 THz), several challenges, such as power consumption and inefficient coupling to the terahertz radiation, leave a gap in semiconductor technology. Hence, future Earth and space science missions need new compact heterodyne receiver solutions with improved energy conversion efficiency. Millimetre wave, antenna-integrated, InP-based Schottky barrier mixers have shown high sensitivity at a small cost in power consumption (local oscillator). Still, InP-substrates are fragile and not suitable for supra-terahertz circuits. Therefore, combining robust, integrated silicon membrane technology with InP-based electronics can potentially revolutionise future space terahertz instrumentation. This approach will enable compact, efficient and advanced room-temperature heterodyne receivers for far-infrared space science instruments and trigger future research on terahertz electronics in various applications.

Mots-clés : terahertz electronics,radiometers,instrumentation,nanoelectronics,detectors,semiconductors,mixers,receivers
Projet ERC : VOICES (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Texts and Concepts
Entité participante : École française d'Extrême-Orient — Pays : France — Rôle : Partner
Acronyme de l'entité : EFEO
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 70800.0 €

VOICES offers a new, large-scale perspective on the history of song-performing cultures of South India in premodern and colonial contexts. More than a song, pattu stands for a multitude of interrelated constellations of song traditions - a galaxy of regional song cultures. One region alone (Kerala) boasts nearly eighty song genres, many of epic proportions: from songs of heroes and place through verses to awake a deity or activate a curse, to songs of ecstatic praise. Most are embedded in recurring ritual events, linked to matrilineal order and performers of subaltern roots. Some connect to minorities: Christians, Muslims, Jews. Pattu invokes practices of deploying skills stored in songs to cure diseases, restore prosperity, empower listeners, or otherwise affect reality. From the 13th c. CE on, the song genres influenced literary forms as trans-medial textuality and cultural technology to store knowledge and generate trust. This rich universe remains understudied. Building a digital archive, VOICES will explore ways in which the sonic ecumene of singing the local in shared imaginary of the South proved resilient over centuries and embraced two languages of prestige: Tamil and Sanskrit. We shall study ontologies of singing the body, the suffering and deliverance, the humane and divine, movement and restraint in this unique subaltern record. We aim at a new understanding of the processes of forging identities at the crossroad of the literary and folk by mapping genre distribution, narrative patterns, transmission modes and cultural economies while identifying key moments of historical change. Fusing ethnomusicology, media and literary studies, VOICES wants to show why tracking this evolution has the potential to reveal intriguing trajectories of the formation of premodern expressive ecologies. Enriched by optics of genre economy, it promises new analytical tools for studying infrastructures of communication and meaning-making practices across South Asia and beyond.

Mots-clés : songs,song studies,literary cultures,performative genres,south asia,india,oral history,history of south india,malayalam,premodern studies,colonial studies,ethnomusicology,media archeology
Projet ERC : CRIMLIFE (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Soci al World and Its Interactions
Entité participante : Harran University — Pays : Turquie — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 38750.0 €

How do social contexts determine paths into crime? How do these trajectories vary across different societal circumstances? And how are they narrated? CRIMEGLO is the first-ever large-scale comparative life-course criminological study globally. No research hitherto has addressed criminal careers and storytelling in such detail and on the scale envisaged in this project. The approach will counterweight the current Northern bias in research and theory, a shift necessary to establish a truly global perspective within life-course criminology. Cultural and societal contexts play a large role in defining and responding to crime. Social conditions shape the life-courses of those getting caught up in the criminal justice system. Context is also intertwined with the ways people talk about their lives. CRIMEGLO will explore and compare crime from a life-course and life-story perspective spanning four continents and six countries: Norway, the Czech Republic, Türkiye, Nigeria, Bangladesh, and Colombia. By combining criminological theory with institutional, cultural, and narrative studies, CRIMEGLO’s goal is to establish global comparative research on crime within a life-course perspective. The primary objective is to introduce and theoretically develop a contextually sensitive, comparative global life-course criminology. The secondary objective is to achieve a better empirical understanding of the particular social, economic, institutional, and gendered factors shaping criminal life-courses in different countries with highly divergent societal contexts. Principal Investigator Sveinung Sandberg is a sociologist and one of Europe’s leading qualitative criminologists. He has pioneered the prominent research traditions of Bourdieusian Criminology and Narrative Criminology. With CRIMEGLO, he expands globally his qualitative work on life-courses and life-stories started in Latin America and, for the first time, incorporates quantitative and comparative methods to his research.

Mots-clés : sociology,criminology,narrative criminology,life course analysis,life history analysis,crime
Projet ERC : Byz-GOVAG (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Study of the Human Past
Entité participante : Hellenic Ministry of Culture and Sports — Pays : Grèce — Rôle : Partner
Type d'entité : Organismes publics (hors enseignement & recherche)
Financement ERC de l'entité : 139900.0 €

Crucial to Byzantium’s survival against several post 6th-century external foes was the introduction of the theme-system (military-territorial units), which sealed its provincial administration for five centuries. The long debate on this institution, often biased by anachronistic evidence from literary sources, has gained new impetus through the study of seals, the tiny lead disks that the Byzantines used to secure and authenticate their correspondence. The plethora of irrefutable evidence that seals provide on the administrative nomenclature and the prosopography of high- and (the otherwise unattested) low-ranking officials, allow the in-depth analysis of a special group of individuals directly linked to the state, whose professional performance and unobstructed succession in office was a prerequisite for the Empire’s cohesion and well-being.  An international team of researchers will apply a well-tested methodological model on the recording and analysis of seals to study relevant material in more than 100 collections worldwide (including hundreds of unpublished seals from Cyprus, Greece and Turkey) and offer in-depth prosopographic analysis of the officials who manned the themes and contributed to Byzantium’s long-lasting endurance. An innovative geo- and chrono-referenced database of seals with secure findspots will, for the first time, visualise the Byzantine correspondence network, and data on the iconography of the seals and the historical, archaeological and sigillographic profile of the thematic headquarters will further revolutionize our hitherto perception of the military, social and cultural history of Byzantium. Printed and online publications, three open access databases, an updated manual on dating criteria for seals, scientific meetings, exhibitions, and an educational programme (designed also for people with special needs) will disseminate the results of the project and guarantee their future use in the study of the European Middle Ages.

Mots-clés : byzantine prosopography,sigillography,administration,historical geography,urbanism
Projet ERC : RESOUND (Horizon Europe, appel 2022, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Texts and Concepts
Entité participante : Université complutense de Madrid — Pays : Espagne — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1087750.0 €

Plainchant, the sacred Christian chant, is the most ancient Western corpus preserved in musical notation. Before the unifying adoption of the Gregorian liturgy throughout Europe in the 9th century, a number of liturgical families –each one with its own chant repertoire– emerged in the ancient Western Roman provinces. Among them, the Hispanic liturgy was recorded –text and music– in manuscripts between ca. 700 and ca. 1300. These sources allow us to know the liturgy’s ceremonies and texts, but not the melodies themselves. In fact, notational signs do not indicate the specific intervals between the notes, since they were written prior to the use of a notational system in which each individual sign contains precise pitch information. As a consequence, the Hispanic musical notation is considered indecipherable and its thousands of melodies still remain silent.  RESOUND aims to achieve what has so far been considered an impossible task: bringing to life the sounds of Hispanic chant. To accomplish this goal, we will use tools from the fields of bioinformatics, genetics, computational analysis, aural architecture and virtual restoration of sound and images, along with tools from the humanities, including musical performance. Computational analysis aside, these tools have never been used in the study of medieval chant, let alone in combination. By recovering the sounds of Hispanic chant and establishing these innovative methods, we will be able to offer new understandings of the generative and evolutionary dynamics of the European plainchant repertoires. In this way, we will not only recuperate the Hispanic melodies, but also restore a significant part of the soundscape of medieval Europe. Thus, by reversing the standard approach via focusing on a territory considered peripheral, we will shed new light on the process of cultural creation in the European Middle Ages.

Mots-clés : digital humanities,big data,computational analysis,plainchant,medieval music,creation processes
Projet ERC : NANOBAC (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Life Science
Panel : Integrative B iology : from Genes and Genomes to S ystems
Entité participante : Université de Lund — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2485312.0 €

Vaccines are the most effective single measure to protect populations against infectious diseases without promoting antimicrobial resistance (AMR). In this proposal, I intend to harness the rapid developments in protein design and quantitative and structural mass spectrometry to i) enable detailed molecular characterization of circulating serum antibody repertories, ii) establish a generalizable framework for antibody-guided design of next-generation nanoparticle vaccines against bacteria and iii) use the developed nanoparticle vaccines to investigate structural properties of protective antibody responses required for immunity. The planned work relies on identifying and producing protective antigen-specific monoclonal antibodies from immune individuals. These antibodies are used to structurally characterize conserved epitopes in their correct three-dimensional conformation. The structural information is then harnessed to design multivalent nanoparticle vaccine candidates. The planned work is focused on i) determining the optimal combination of epitopes that generates the highest level of protection using Streptococcus pyogenes as a model system, ii) determine the molecular properties of the circulating serum antibody response that mediates the protection and iii) modify the epitope design to target conserved structural motifs typically found within protein families to produce immunogens that confer cross-pathogen protection.  The work will be novel as it will for the first time, demonstrate the design of a protective vaccine candidate against a protein family associated with distinct bacterial pathogens and infections. The concept will be extendable to other protein families and bacterial pathogens to aid in the combat against AMR.

Mots-clés : structural proteomics,quantiative proteomics,vaccine design,biological mass spectrometry,infectious disease,hydrogen deuterium exchange mass spectrometry,cross linking mass spectrometry
Projet ERC : DualControl (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Systems and Communication Engineering
Entité participante : Université de Lund — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2500000.0 €

In recent years, data-driven control in high dimensions has penetrated into many new application areas. Examples include control of autonomous vehicles based on video data, simulation based prediction of turbulent flows and precision medicine based on gene sequencing time series data. Large data sets come with significant computational challenges. Tremendous algorithmic progress has been made in machine learning and related areas, but application to dynamical systems is hampered when the number of time samples is small compared to state dimensions, while latency and stability remain central concerns. As a result, learning-based feedback in high dimensions is still carried out without a solid theoretical foundation. This leads to unpredictable behavior, which is a major bottleneck for efficient and resilient control of complex systems in engineering and medicine.  The term dual control was introduced in the 1960s to describe the tradeoff between short term control objectives and actions to promote learning for long term performance. A variety of algorithms have been developed to address the problem, but rigorous dynamic analysis is still restricted to systems of low dimension. We propose to address the high-dimensional challenges using a new set of tools based on system theory for positive cones. The cone concept is already well established in the context of sparse matrix theory, compartment models and optimal transport. However, its systematic use for dual and adaptive control remains unexplored. Preliminary results suggest that we are still very far from full exploitation of its algorithmic and analytic potential.  Theory and algorithms will in this project be developed in close interaction with researchers studying single cell genetic time series data as a basis for cancer immunotherapy. Learning-based control laws for individually optimized therapy will be developed based on data from cancer tumors.
Projet ERC : CoDeFeL (Horizon Europe, appel 2022, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Mathematics
Entité participante : Université Friedrich-Alexander d'Erlangen-Nuremberg — Pays : Allemagne — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1185565.7 €

Machine Learning (ML) is forging a new era in Applied Mathematics (AM), leading to innovative and powerful methods. But the need for theoretical guarantees generates challenging, fundamental, deep mathematical questions. This great challenge can be addressed from the perspective of other, more mature areas of AM. CoDeFeL seeks to do so from the rich interface between Control Theory (CT) and ML, contributing to the analytical foundations of ML methods, significantly enlarging, and updating the range of applications of CT. As our recent results show, classification, regression, and prediction problems in Supervised Learning (SL) and the Universal Approximation Theorem can be successfully recast as the simultaneous or ensemble controllability property of Residual Neural Networks (ResNets). Following this path, we will develop ResNets of minimal complexity and cost, addressing the deep, intricate issue of linking the structure of the data set to be classified with the dynamics of the networks trained. Taking the turnpike principle as our inspiration, we will build new simplified ResNet architectures. This, however, raises major challenges for the genuinely nonlinear dynamics that ResNets represent.Adjoint methods will also be developed and applied, to understand the sensitivity of ResNets, and proposing techniques for Adversarial Training and computing Saliency Maps, applicable in Unsupervised Learning. The project is strongly inspired on the challenges arising in relevant applications in digital medicine and internet recommendation systems, among other areas. Accordingly, we will also develop a body of rich, hybrid, cutting-edge methods for data-aware modelling, combining ResNet surrogate models and those inspired on Mechanics, with the aid of Model Predictive Control strategies. New Federated Learning methodologies with privacy preservation guarantees will also be developed. The computational counterparts will be brought together in a new CoDeFeL GitHub repository.

Mots-clés : supervised learning,data aware modelling,federated learning
Projet ERC : MM-ZERO (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Synthetic Chemistry and Materials
Entité participante : Université Friedrich-Alexander d'Erlangen-Nuremberg — Pays : Allemagne — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2499856.0 €

Historically, main group metal organometallics are used as stoichiometric reagents in organic synthesis. This holds especially for highly polar s-block metal compounds like BuLi or Grignard’s. Only since the start of this century, it has been recognized that they also make for remarkably versatile catalysts. Parallel to these developments, the low-oxidation-state chemistry of the early main group metals emerged with the seminal isolation of first MgI complexes. Since 2007 numerous examples have been reported. First highly reactive complexes of an s-block metal in the formal zero-oxidation-state (ZOS) were reported by our group (“Strongly reducing magnesium(0) complexes”, Nature 2021, 592, 717). MM-ZERO aims to develop main group metal chemistry in the ZOS. In contrast to transition metals, for which there are many examples of TM(0) complexes, it is a bold challenge to isolate complexes of electron-rich main group metals. This holds especially for the electropositive s-block metals. Devoid of d-orbitals for backbonding, they easily oxidize. Building upon our preliminary work, we propose strategies to advance ZOS main group metal chemistry and push the frontiers of knowledge. Smart ligand design and the introduction of ball-milling are key to access hydrocarbon-soluble complexes with ZOS-metals of groups 1-3. While this first part is of fundamental nature, the second part of the project aims to activate main group metals for hydrogenation catalysis. Preliminary work shows that Ba activated by Metal-Vapour-Synthesis (MVS, i.e. cocondensation in an organic matrix) is an unexpectedly active alkene hydrogenation catalyst. Moreover, in combination with MVS-activated Fe, benzene can be even hydrogenated at 20 °C. Ba/Fe-cooperativity is demonstrated by the fact that both metals alone are not active. Combining abundant main group and 3d-TM’s, it is our ultimate goal to develop sustainable, highly active (de)hydrogenation catalysts for hydrogen storage applications.

Mots-clés : metal activation ball milling metal vapour synthesis hydrogenation catalysis sustainability