Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : FOLOF (Horizon Europe, appel 2021, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Synthetic Chemistry and Materials
Entité participante : Université Louis-et-Maximilien de Munich — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : LMU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2500000.0 €

Protein-nucleic acid interactions (PNIs) play a central role in biology and their control would enable long-desired biological interventions and future therapeutic applications. However, synthetic molecules that reproduce the overall shape and surface features of nucleic acids to interfere with PNIs have been lacking because, up to now, it has not been possible to design such extended and complex abiotic interactions interfaces. Due to their distinct chemical composition, predictable shapes, large size and conformational stability, aromatic oligoamide foldamers (AOFs) are prime candidates for breaking new ground in this field. FOLOF aims to develop AOF-based surface mimics of the B-DNA double helix targeted to the large ensemble of sequence-selective PNIs mediated by alpha-helices.  Based on the PI’s expertise in AOF science, FOLOF will proceed by 1) expanding the chemistry tool box to enable specific design objectives; 2) optimizing the automation of AOF synthesis for the fast delivery of long sequences; 3) identifying structural features of protein-foldamer complexes and specific foldamer features that make them outcompete DNA binding; 4) establishing protocols to iteratively improve protein binding affinity and selectivity for AOFs, and AOF-DNA covalent hybrids; and 5) developing computational tools for ab initio AOF-based DNA mimic design. Through a strategic combination of chemical synthesis, computational predictions, crystallographic structural analysis, binding studies, and screening tools, FOLOF will push the production of abiotic molecular mimics of nucleic acids to a completely new ensemble.

Mots-clés : foldamers,molecular recognition,alpha helices,protein surface recognition,molecular design
Projet ERC : explorer (Horizon Europe, appel 2022, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Computer Science and Informatics
Entité participante : École nationale des ponts et chaussées — Pays : France — Rôle : PI
Acronyme de l'entité : ENPC
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2476718.0 €

In the 'explorer' project, we will develop methods for automatically capturing and labelling video data in "open worlds". The ultimate goal is the great facilitation of the creation and maintenance of Digital Twins: Digital Twins are virtual 3D copies of complex scenes such as cities, factories, or construction sites. Not just a 3D reconstruction, they should capture the scene's semantics, i.e. the identity of each object and the scene's dynamics, i.e. how objects move. Because Digital Twins have the potential to be extremely useful for monitoring large complex sites and planning the development of these sites, their forecast market is huge, they remain mostly a concept because of important limitations of the current technology. Our methods will guide autonomous systems such as robotic platforms and UAVs through complex and unknown environments to capture visual data for creating and maintaining Digital Twins. This is extremely challenging as these systems will encounter objects without any prior knowledge about them and will have to collect sufficient data about them. To the best of our knowledge, this active and automatic capture in complex real environments is a new problem. It is however very important to solve it as this will relax the need for human expertise and time: Currently, capturing such data is done manually only by researchers and requires strong understanding of what the learning algorithms require. To tackle the complexity of this problem, our approach is inspired by techniques from Artificial Intelligence applied to the exploration of extremely large trees. This approach will allow us to bring the perception part and the planning part of the problem together under the same optimization framework, to formalize it and solve it efficiently. To evaluate our developments, we will create a dataset of annotated video sequences from working sites, which we will share with the community.
Projet ERC : CoCoDyMo (Horizon Europe, appel 2024, Advanced grants)
Domaine scientifique : Life Science
Panel : Prevention,  Diagnosis and T reatment of Human Diseases
Entité participante : Université d'Oxford — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2497921.0 €

Infections are a leading cause of mortality and morbidity. Among these, tuberculosis (TB), malaria, HIV/AIDS and Neglected Tropical Diseases (NTDs) are the main contributors to the global burden of disease, particularly in Sub-Saharan Africa, where these chronic infections predominantly affect impoverished communities. Despite increasing evidence that these diseases affect the same populations and that interactions between them impact disease transmission and control, the complex, non-linear dynamics of co-infections with multiple NTDs, TB, malaria or HIV/AIDS, and the implications of these dynamics for disease control remain unknown. Therefore, in CoCoDyMo, we propose to integrate my deep expertise in data sciences, mathematical modelling of infectious diseases and health economics to gain novel insights into co-infections between NTDs, TB, malaria and HIV/AIDS and optimize the integrated control of these diseases. First, we will map, at a fine geographical scale across Sub-Saharan Africa, where NTDs, TB, malaria, and HIV/AIDS are likely to be co-infectious. Then, we will develop new methods to dynamically model relevant co-infections, to understand the life course history of co-infections, elucidate some of the biological questions surrounding the interactions between different pathogens, and how these influence disease progression and control. Finally, we will forecast future trends in disease transmission and evaluate the likely synergistic impact of different interventions (drug administration, vaccines, and surveys) across multiple diseases, both in terms of health and economic benefits. These efforts, at the frontier of infectious disease research, will provide novel insights into the fundamental biology of co-infections with NTDs, TB, malaria and HIV/AIDS and pave the way for exploring relevant policy questions around the integration of disease-specific programs into unified efforts that can maximize the benefits to vulnerable populations.
Projet ERC : GOAT (Horizon Europe, appel 2021, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Mathematics
Entité participante : Centre national de la recherche scientifique — Pays : France — Rôle : PI
Acronyme de l'entité : CNRS
Type d'entité : Recherche
Financement ERC de l'entité : 1439368.75 €

During the last decade, spectacular achievements have been performed in the study of groups of birational transformations of algebraic varieties. We now have a detailed understanding of such groups in dimension 2. Far less is known in higher dimensions, but the last five years saw the birth of a large array of techniques that apply in arbitrary dimensions. They include powerful tools from p-adic analysis, isometries of CAT(0) cube complexes, pluripotential theory, and algebraic geometry. Simultaneously, recent arithmetic equidistribution theorems have been combined with holomorphic dynamics to solve problems of unlikely intersection in the dynamics of polynomial maps and to study parameter spaces of such maps. The novelty of this proposal will be to combine these recent advances coming from two active sujects.  I propose to develop a global study of groups of algebraic transformations of higher dimensional varieties, both from the dynamical and the algebro-geometric viewpoints. I have been developing this program progressively during the last ten years. Moving to higher dimensions is crucial to broaden the range of applications and is now possible with the advances mentioned above.  The first leitmotif will be the large scale geometry of groups of birational transformations. The second will be the dynamics of natural actions of such groups on families of geometric objects, notably on families of rational surfaces and on character varieties. There a three long term goals: (a) to extend some of the geometric features of linear groups to all groups acting faithfully by algebraic transformations (this includes the mapping class groups of closed surfaces, for instance); (b) to compare the geometry of distinct (rationally connected) varieties through a comparison of their groups of birational transformations; (c) to get new properties of families of geometric objects (such as rational surfaces) via dynamics in their parameter or Teichmüller spaces.

Mots-clés : group theory
Projet ERC : MITOFOLD (Horizon Europe, appel 2023, Advanced grants)
Domaine scientifique : Life Science
Panel : Cell Biology, Development, Stem Cells and R egeneration
Entité participante : Laboratoire européen de biologie moléculaire — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : EMBL
Type d'entité : Recherche
Financement ERC de l'entité : 3118430.0 €

Mitosis is a fundamental biological process every cell undergoes at least once. It requires a dynamic and dramatic restructuring of the genome from extended interphase chromatin to compact individual mitotic chromosomes capable of faithful segregation. Altered nucleosome interactions, phase separation and loop extrusion have all been proposed to play important roles in shaping mitotic chromosomes. However, what the internal architecture of single mitotic chromosomes is, and how this architecture is established in space and time by different forces inside the cell remains unclear. This lack of knowledge precludes a comprehensive mechanistic understanding of mitotic chromosome folding and unfolding. This project aims to resolve the folding principles of chromosomes during mitotic compaction and decompaction in situ, in single human cells. To achieve this, we will combine newly developed nanoscale DNA tracing technology with quantitative single protein imaging approaches to achieve a systematic structural analysis of mitotic chromosome folding throughout mitosis. We will investigate when and where which structural features are first established, and then use targeted, acute perturbations to dissect which regulators are required to form and maintain them. The resulting data will provide an in situ structure-based model to explain the essential function of the genome in mitosis and will allow us to understand the spatio-temporal coordination of the underlying molecular and physical mechanisms. Overall, the proposed project will provide a new framework for understanding the physiological and pathological roles of mitotic chromosome restructuring during cell division.
Projet ERC : EXPEDITE (Horizon Europe, appel 2022, Advanced grants)
Domaine scientifique : Life Science
Panel : Prevention,  Diagnosis and T reatment of Human Diseases
Entité participante : Innovavector srl — Pays : Italie — Rôle : Partner
Type d'entité : Organismes privés (hors enseignement)
Financement ERC de l'entité : 100000.0 €

In vivo gene therapy based on a single administration of adeno-associated viral (AAV) vectors is emerging as an effective therapeutic option for both monogenic and complex diseases. Given the episomal nature of the AAV genome, its applications are limited to non-replicating tissues like retina or adult liver. Several AAV-based products that target these tissues are either approved or in advanced clinical development. Despite this, some limitations still remain, including: the potential for insertional mutagenesis associated with genome-wide AAV integration; the loss of transgene expression from replicating tissues like newborn liver; and the challenge to counteract toxic gain-of-function mutations, which cause dominant diseases for which canonical gene replacement is ineffective. EXPEDITE aims to integrate therapeutic DNA at desired genomic loci safely and effectively, thus overcoming the above limitations. EXPEDITE will go beyond the current state-of-the-art by implementing and comparing two parallel strategies: (i) novel Cas fusion proteins to recruit DNA repair machineries at induced double stand breaks (DSBs) to maximize on-target donor DNA integration; (ii) novel cleavage-free platforms for therapeutic DNA integration, based on transposases or bacterial single strand-DNA annealing proteins. The therapeutic relevance of these platforms will be tested in the retina and liver, two highly relevant tissues for gene therapy, using animal models of inherited retinal degenerations and lysosomal storage diseases, respectively, and, ultimately, non human primates. To reduce the risk of potential off-targets, EXPEDITE will also test non-viral vectors for transient delivery of the genome editing tools while delivering the donor DNA via AAV. The results from EXPEDITE will allow significant expansion of the patient population that can benefit from in vivo gene therapy and may represent a change of paradigm for gene therapy by replacing canonical gene addition approaches.

Mots-clés : gene therapy,adeno associated viral vectors,aav,genome editing,liver,retina
Projet ERC : CHIRAX (Horizon Europe, appel 2022, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Physical and Analytical Chemical Sciences
Entité participante : Université de Trieste — Pays : Italie — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 232875.0 €

The purpose of this proposal is to implement X-ray circular and helical dichroism to investigate the structure and chemical dynamics of molecular systems in solution. The proposal entails first establishing the concepts and observables of X-ray dichroism in steady-state studies both in the soft and hard X-ray ranges, and then implementing time-resolved X-ray circular and helical dichroism spectroscopies as probes of the chemical dynamics.

Mots-clés : chirality,x rays,circular dichroism,helical dichroism,molecular structure,chemical dynamics,liquid solutions,time resolved studies,synchrotrons,x ray free electron lasers
Projet ERC : Pain Channels (Horizon Europe, appel 2023, Advanced grants)
Domaine scientifique : Life Science
Panel : Neuroscience and Disorders of the Nervous System
Entité participante : Max Delbrück Center — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : MDC
Type d'entité : Recherche
Financement ERC de l'entité : 2500000.0 €

Pain results from activation of the nociceptive sensory system, which is built upon the primary afferent nociceptor a type of sensory neuron specialized to detect, code and relay information about potentially or actually damaging stimuli. Humans lacking properly functioning nociceptors never experience pain and have reduced life expectancy and suffer severe disability. Nociceptors detect sustained force into ranges that are potentially damaging and sustained nociceptor activation will always lead to pain. It has been assumed that mechanical force transduced by nociceptors requires mechanically activated ion channels in the nociceptor membrane. However, recent data suggests that sensory Schwann cells that wrap the nociceptor ending also participate in force transduction. The aim of this proposal is to identify molecules specifically involved in nociceptor force transduction at this neuroglial site. We have already identified an ion channel (Tmem87a/ELKIN1) and an extracellular tether protein (TENM4) as being involved in nociceptor force transduction. In addition, STOML3 modulates ELKIN1 function and can sensitize almost all nociceptors to mechanical force. The identification of a set of molecules involved in force transduction (ELKIN1/TENM4/STOML3) will allow us to design “guilt by association” approaches to identify new players. We will use ultra-low input spatial proteomics, BioID and high throughput electrophysiological screening to achieve this aim. We have designed novel genetic strategies to interrogate the function of candidate proteins in nociceptor force transduction with timescales ranging from weeks to minutes. This ambitious and challenging project promises to deliver novel molecular targets that can be used to specifically target nociceptor force transduction. Specific targeting of nociceptor force transduction could be a powerful new way to treat multiple pain types poorly served by existing therapies.

Mots-clés : ion channels,biophysics,perception,behavior
Projet ERC : IneQint (Horizon Europe, appel 2023, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Soci al World and Its Interactions
Entité participante : Université d'Oxford — Pays : Royaume-Uni — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 215942.04 €

Socioeconomic inequality has become increasingly intertwined with immigrant status in many Western European societies. One important question is whether and how socioeconomic disadvantages among immigrant parents hamper the integration of their children. This project focuses on inequality and spatial segregation, and how they affect the children of immigrants in terms of their wellbeing and structural, social and cultural integration. We ask how integration in different dimensions comes to be, analyzing the internal workings of schools, including grading, ability grouping, and social relations among classmates. The complex nature of the questions we address requires outstanding and up-to-date data: one of the major contributions of this project is to collect such data. This will be achieved via a longitudinal survey conducted among 5000 pupils in 100 representative Swedish comprehensive schools, coupled with parent, register and digital data. The project also offers excellent opportunities to assess changes in inequality and integration over the last 15 years through comparisons with pre-existing data. Sweden provides a particularly interesting case due to its high immigration (particularly from the Middle East and Africa’s horn), increasing income inequality, growing ethnic and socioeconomic school segregation, and rapidly decreasing support for immigration. The data will make it possible to study changes in inter-ethnic social relations, attitudes, values, religiosity and subjective wellbeing over time – all within the context of the structural opportunities set by inequality and segregation. The study also obtains information (from teachers, headmasters and registers) on school organization, resources, and climate, producing a comprehensive picture of the school setting. In this sense, it is more than a survey conducted in schools; it is a survey of schools, the pupils that populate them, and the resources and milieu they are embedded in.

Mots-clés : inequality,structural integration,social integration,cultural integration,intergroup relations,wellbeing,youth,segregation,immigration,stratification,education
Projet ERC : FROM STONE TO HOME (Horizon Europe, appel 2023, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Study of the Human Past
Entité participante : Académie autrichienne des sciences — Pays : Autriche — Rôle : Partner
Acronyme de l'entité : ÖAW
Type d'entité : Recherche
Financement ERC de l'entité : 129917.5 €

This project explores the emergence of value and wealth as a concept in human history. Social and economic changes accelerated during the Neolithic, but until now it remains unclear what triggered inequality in these communities. Thus, the project aims to nuance how inequality evolved in human history. To approach this key question the study will investigate social and economic transformations initiated by the appearance of polished stone tools (axes, adzes, chisels and wedges) recovered from Neolithic sites, burials, households and quarries from the 7th to the 4th millennium BC in the Aegean. The project hypothesis is linking the Neolithic human awareness of raw material availability and biographies of polished stone tool assemblages with the abstract concepts of the different kinds of value and wealth in these communities. The project will pursue its objectives by initiating four work packages which will, for the first time, document and compare polished stone tools made of rare (jadeitite, nephrite, omphacitite or eclogite) and common (serpentinite, andesite, basalt, gabbro and hematite) raw materials from sites, burials and households in selected synchronic and diachronic case studies. By revealing the location of previously unknown raw material sources and quarry sites of polished stone tools, the project will be able to discover the interrelations between local, regional and superregional exchange networks. Through techno-morphological, use-wear and contextual analysis of polished stone tools, it will be possible to qualify and quantify the different stages of the studied objects, from procurement, manufacture and usage to the final deposition. The data from the polished stone tool assemblages will be related to other materials (lithics, ceramics, bones, shells, obsidian, flint, copper and gold) from the studied sites, burials and households, in order to identify new aspects related to the value of objects and fluctuations in wealth and inequality.

Mots-clés : neolithic,stone tools,aegean,value,wealth
Projet ERC : SelfEnergyDriver (Horizon Europe, appel 2024, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Materials Engineering
Entité participante : Rede de Química e Tecnologia — Pays : Portugal — Rôle : PI
Acronyme de l'entité : REQUIMTE
Type d'entité : Recherche
Financement ERC de l'entité : 1992329.0 €

In the landscape of wearable electronics, there is a demand for self-powered systems to address the challenges posed by discontinuous and limited power supply. Low-grade heat and moisture are two ubiquitous clean energy sources with great potential for electrical energy production. 2-in-1 technologies combining thermal or moisture-induced energy harvesting (EH) with electrochemical energy storage (ES) are attractive self-charging solutions for wearables. However, their performance remains inconsistent and unsteady. The understanding of the underlying EH and ES mechanisms remains fragmented, without considering synergistic opportunities. SelfEnergyDriver proposes a PIONEER HYBRID textile technology UNIFYING moisture-triggered EH, thermal EH and supercapacitive ES. This groundbreaking 3-in-1 concept aims for the self-sustained harvesting of two clean energy sources and simultaneous in situ storage of the captured energy. Non-toxic multifunctional hybrid electrode nanomaterials with 3D porous architecture, redox-active nature and precisely engineered moisture permeability, thermal and electrochemical properties will be developed to comply with all EH/ES requirements. These hybrids will be incorporated in textiles and assembled with advanced redox-active ionic hydrogel polyelectrolytes in innovative device architectures. SelfEnergyDriver will delve into the intricacies of electrodes, electrolytes, and their interfaces, to guide the rational design of these trailblazing technologies and foster cooperative effects for synergistically-enhanced outputs. The supreme goal will be bridging the knowledge gap between electrode/electrolyte properties, interface phenomena, device architecture and performance. As a proof-of-concept, the 3-in-1 technologies will be tested under simulated real-world conditions, to showcase their potential to revolutionize the landscape of wearable energy systems. The acquired knowledge will set new landmarks in clean energy, textronics and sensing.

Mots-clés : 3d porous hybrid nanomaterials self powered multifunctional smart textiles energy technologies moisture induced energy harvesting thermal energy harvesting self chargeable supercapacitors