Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : MIGHTY (Horizon 2020, appel 2019, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : University of Cambridge — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : U. Cambridge
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1997723.0 €

Research in the field of micro and nanotechnology has led to the development of materials with fundamentally new or improved functionality, which have the potential to revolutionise electronics, drug delivery, water purification, and energy storage. These scientific discoveries can help address many of the grand challenges our society is facing, but unfortunately, too few of these new materials are implemented in real commercial devices. This is not because of a lack of interest or commercial potential, but often because there are no manufacturing methods available that allow for controlled processing of these materials at scale. This project aims to address this challenge by developing advanced nano and microstructures directly on a scalable Roll-to-Roll manufacturing platform, rather than considering manufacturing as an after-thought. This will be achieved by following a methodical approach, where material organisation is optimised from the bottom-up, starting with the nanoscale chemical material composition, followed by the microscale particle morphology, and finally their large area coating using Roll-to-Roll manufacturing. This hierarchical material build-up will be achieved by taking advantage of emerging scientific insights in robust self-assembly processes, combined with novel coating processes to allow for precise control over the particle flow and assembly on Roll-to-Roll. Our Roll-to-Roll process will be optimised to manufacture Li-Ion batteries with new form factors that allow the enhancement of their volumetric performance. This project will demonstrate for the first time how complex hierarchical battery electrodes can be manufactured with a continuous process. These batteries are important to support the EU’s strong automotive industry as it transitions to electric vehicles, and therefore this project will contribute to the EU economy as well as to the de-carbonisation of our society.

Mots-clés : li ion batteries,roll to roll manufacturing
Projet ERC : CIRGEN (Horizon 2020, appel 2017, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Valencia — Pays : Espagne — Rôle : PI
Acronyme de l'entité : UV
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2499415.0 €

Research on the role played by women as actors and by gender as a cultural category has crucially contributed to historiographical revision of the Enlightenment and its legacy to the modern world. However, the perspective adopted has been national or, if comparative, mostly radial. A leap forward is urgent because current circulationist approaches to the Enlightenment tend to forget its key gender dimension and to underplay contributions from Southern Europe. This projects offers, for the first time in the field, a systematic,truly transnational and transatlantic approach, which knits together cultural, intellectual, gender and postcolonial history, literary, philosophical and visual studies. It looks at the cultural transfer of gender notions in global perspective around five axes: translation, learned sociability, travel, reading and sensibility, to be explored through textual and iconographic analysis and archival research. Adopting the vantage point of Spain and its empire will allow to question approaches based either on the “national context” or the centre-periphery dichotomy, to reassess the role of the Catholic Enlightenment in the making of modernity and to highlight the mediating roles played by local actors, male and female, in processes of sociocultural change. CIRGEN’s specific objectives are: to challenge dichotomous visions of Enlightenment discourses of gender by stressing their plural (and often conflictive) contribution to modernity; to decenter customary radial perspectives by stressing multilateral dialogues both within Europe and beyond; to better understand the role played by gender in the cultural geography of Enlightenment, particularly in the construction of the South/North symbolic divide; to produce empirically grounded evidence of the practical and iconic role of women in the making of modern reading publics; to foster innovative scholarship on the gendering of emotions in defining national identities and moral standards of civilization.

Mots-clés : women,cultural transfer,translation,communication,hybridism,centres and peripheries,european south,transatlantic history,postcolonial studies,individual agency,sensibility,sociability
Projet ERC : COMPLEX-FISH (Horizon 2020, appel 2017, Consolidator grants)
Domaine scientifique : Life Science
Panel : Environmental Biology, Ecology and Evolution
Entité participante : University of Jyväskylä — Pays : Finlande — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1999391.0 €

Resilience and recovery ability are key determinants of species persistence and viability in a changing world. Populations exposed to rapid environmental changes and human-induced alterations are often affected by both ecological and evolutionary processes and their interactions, that is, eco-evolutionary dynamics. The integrated perspective offered by eco-evolutionary dynamics is vital for understanding drivers of resilience and recovery of natural populations undergoing rapid changes and exposed to multiple stressors. However, the feedback mechanisms, and the ways in which evolution and phenotypic changes scale up to interacting species, communities, and ecosystems, remains poorly understood. The objective of my proposal is to bridge and close this gap by merging the fields of ecology and evolution into two interfaces of complex biological dynamics. I will do this in the context of conservation and sustainable harvesting of aquatic ecosystems. I will develop a novel mechanistic theory of eco-evolutionary ecosystem dynamics, by coupling the theory of allometric trophic networks with the theory of life-history evolution. I will analyse the eco-evolutionary dynamics of aquatic ecosystems to identify mechanisms responsible for species and ecosystem resilience and recovery ability. This will be done through systematic simulation studies and detailed analyses of three aquatic ecosystems. The project delves into the mechanisms through which anthropogenic and environmental drivers alter the eco-evolutionary dynamics of aquatic ecosystems. Mechanistic understanding of these dynamics, and their consequences to species and ecosystems, has great potential to resolve fundamental yet puzzling patterns observed in natural populations and to identify species and ecosystem properties regulating resilience and recovery ability. This will drastically change our ability to assess the risks related to current and future anthropogenic and environmental influences on aquatic ecosystems.

Mots-clés : eco evolutionary dynamics,ecosystems,life histories,recovery ability,resilience
Projet ERC : EURO-EXPERT (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : University of Oxford — Pays : Royaume-Uni — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 700456.87 €

Respect for diversity has been at the forefront of political accession to the European Union since 1993 and socio-legal scholarship has developed articulated reflections on the accommodation of ethnic and religious minorities in Europe. Country-experts have been instructed with increasing frequency in judicial and pre-judicial proceedings involving members of diasporic communities. In some common law countries the role of the expert witness has expanded to systematically assist the judge when litigants or defendants belong to minorities; in most civil law countries, similar roles are played by translators and cultural mediators, including notaries and lawyers. Cultural expertise is sometimes used in order to avoid excessive judicialisation. Notwithstanding, disbelief is developing around cultural expertise; and, excalations of violence and counter-violence signal that European majority and the so-called minorities are drifting apart. Hence our question: Cultural Expertise in Europe: What is it useful for? A comprehensive assessment of cultural expertise was entrenched by its narrow technical definition. This project develops around a new integrated concept of cultural expertise to empirically investigate its use and impact in fourteen European countries. In-context data will be collected through ethnographic fieldwork conducted by a modular team allowing real time analysis and immediate use of results by the stakeholders. The objectives will be to: 1) map the terms, condition, and costs of cultural expertise in private and public law; 2) create a toolkit for measuring the impact of cultural expertise; 3) establish an open access searchable data base for the consultation of cases and solution including cultural expertise; 4) design a teaching and learning module using the cultural expertise impact toolkit; and 5) formulate policy-making guidelines which include tested solutions for a sustainable inclusiveness in Europe.

Mots-clés : anthropology of law
Projet ERC : m1ARNA (Horizon 2020, appel 2016, Advanced grants)
Domaine scientifique : Life Science
Panel : Integrative Biology: from Genes and Genomes to Systems
Entité participante : Sheba Medical Center — Pays : Israël — Rôle : PI
Type d'entité : Recherche
Financement ERC de l'entité : 2457500.0 €

Reversible epigenetic modifications regulate gene expression to define cell fate and response to environmental stimuli. Gene expression tuning by DNA and chromatin modifications is well studied, yet the effect of RNA modifications on gene expression is only starting to be revealed. More than a hundred chemical modifications decorate RNAs, mainly non-coding ones, expanding their nucleotide vocabulary and mediating their diverse functions. Several modifications were globally mapped in mRNA. Only two, N6-methyladenosine (m6A) and N1-methyladenosine (m1A) exhibit a distinct topology alluding to a functional role. We pioneered the identification of m6A that is located preferentially in distinct transcript landmarks, mostly around stop codons and mediates transcript localization, splicing, decay and translation. We now identified m1A which decorates thousands of genes mainly in the start codon vicinity, upstream to the first splice site. Our preliminary results indicate that m1A dynamically responds to environmental stimuli and plays a central role in translation regulation. The regulation and functions of m1A are still terra incognita. Our objectives are to identify m1A writers and erasers, elucidate m1A readers and the mechanisms whereby m1A dictates downstream outcomes, particularly translation regulation. We will study m1A functions in response to physiologic stimuli and stress conditions in cells and animal models by manipulation of the m1A deposition machinery. As epigenetic marks operate in a context-dependent concerted way we will map m1A marks concomitantly with m6A to decipher their interplay in regulating gene expression via a putative “epigenetic RNA code”. The data obtained from parallel mapping of m1A and m6A at a single nucleotide and a single transcript resolution, will expose the interplay between these two mRNA modifications in the context of multilayer epigenetics. The study of m1A circuits may identify targets amenable to therapeutic manipulations.

Mots-clés : n1 methyladenosine,translation regulation
Projet ERC : RACE (Horizon 2020, appel 2016, Starting grants)
Domaine scientifique : Life Science
Panel : Prevention, Diagnosis and Treatment of Human Diseases
Entité participante : Leiden University Medical Center — Pays : Pays-Bas — Rôle : PI
Acronyme de l'entité : LUMC
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1500000.0 €

Rheumatoid Arthritis (RA) causes long lasting disability. At the time of clinically evident arthritis and diagnosis, the disease is already persisting, requiring long-term suppressive treatment. My overarching aim is to prevent chronic arthritis and RA by inhibiting the evolving auto-immune response in a pre-arthritis phase. Currently, identification of RA-patients before the classic presentation with clinically evident chronic arthritis is beyond the state of the art. I here aim to achieve this early recognition by increasing the mechanistic understanding of pre-arthritis phases. I intend to study RA-specific auto-immune responses at the cellular and humoral level as well as markers reflecting local and systemic inflammation. These aspects are selected based on my world-wide validated rule to predict RA-development in early arthritis and on recent work on progression from Clinically Suspect Arthralgia (CSA) to clinical arthritis. This project is now finally feasible, thanks to unique ‘pre-RA’ cohorts and cross-boundary preparatory work done with basic scientists, clinicians and engineers. My research concept is to integrate the products of separate trajectories in a longitudinal study and translate it to the clinic. Patients with CSA will be studied serially in time. Using validated methods and novel techniques and insights we will: delineate molecular and predictive features of RA-specific auto-antibodies and auto-antibody secreting B-cells, identify improved markers of systemic inflammation and test and validate a computer-aided image analysis system to detect subclinical joint inflammation on MRI. Serial data will be combined to reveal interactions between markers and time relationships. Lastly a prediction model identifying imminent RA will be developed. The forefront position of my group allows national and international validation. Together, this multidisciplinary and intersectorial project will open new horizons for preventive, targeted interventions.

Mots-clés : rheumatoid arthritis,prediction making,secondary prevention,clinically suspect arthralgia
Projet ERC : CHILDROBOT (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : University of Amsterdam — Pays : Pays-Bas — Rôle : PI
Acronyme de l'entité : UvA
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1999012.0 €

Robots used to be made for labor; now, they are increasingly also made for relationships. Social robots can learn from us, teach us, play with us, and assist us. With the market for social robots expected to grow substantially in the next 20 years, social robots are likely to become a life-changing technology similar to personal computers or smart phones. Still, we still know little about one of the most intriguing, relevant, and timely issues in this process – children’s interaction with social robots. Children are not only increasingly recognized and targeted as early adopters of new technologies; they may also be more susceptible to potential effects of interacting with robots than are adults. As research on child-robot interaction (CRI) is still a fragmented field, the main aim of the proposed project is to develop an integrative framework of CRI. This framework synthesizes theories and concepts from communication research, human-robot-interaction, as well as developmental and social psychology in an entirely new way. It will focus (1) on the antecedents of children’s acceptance of social robots; (2) the con-sequences of CRI for children’s learning of social skills from social robots and their relationship formation with them; and (3) the processes that explain why such effects emerge. The project combines survey and experimental research, thereby bringing an unprecedented, but much needed multi-methodological approach to the field of CRI. Focusing on 8-9 year-old children, the project will also provide two crucial methodological innovations: (a) the creation an inventory of standardized measures for CRI and (b) new procedures and research designs to study long-term CRI. In its pioneering focus on a disruptive new technology, its theoretically unifying character, and its original methodological contributions, the project will not only define the field of CRI, but will also present a completely new agenda for it.

Mots-clés : children,prosocial behavior,media effects,learning,new media,technology,relationship formation,robotics
Projet ERC : SMARTLABCAM (Horizon 2020, appel 2019, Proof of concept grants)
Domaine scientifique : Life Science
Panel : Neuroscience and Disorders of the Nervous System
Entité participante : Scuola Internazionale Superiore di Studi Avanzati — Pays : Italie — Rôle : PI
Acronyme de l'entité : SISSA
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 150000.0 €

Rodents have become very popular models of cognitive functions, such as perception, memory and decision-making. Understanding the neuronal substrates of these processes requires performing neurophysiological recordings in awake animals, engaged in complex behavioral tasks. This, in turn, calls for tracking in real-time the motor behavior of the animal, to relate it to the underlying brain activity. Custom, as well as commercial, solutions exist that allows tracking basic behaviors in rodents – e.g., the 2D position and orientation of an animal over the arena where he navigates. However, while carrying out the research of the ERC project LEARN2SEE, we realized that methods for 3D reconstruction of some key behavioral features (e.g., pose of the head and gaze direction) are not commercially available, and the custom solutions found in the literature lack generality and are hard to implement and replicate. This prompted us to develop innovative, minimally invasive and user-friendly solutions to head/eye tracking in rodents. Yet, we soon faced another challenge – in order to perform high-throughput experiments, by testing in parallel many subjects (one of the advantages of rodent models over larger laboratory animals), our head/eye trackers would need to be re-engineered to make them easily replicable for series production. Critically, this would also allow transforming them into commercial devices for the ever-growing market of neurophysiology laboratories that, especially in the field of vision science, are employing rodents as model organisms. Here, we present our plan to achieve this goal, by migrating the tracking algorithms we developed for the LEARN2SEE project to smart cameras, engineered for real-time, on-board processing of head/eye video streams. These cameras will become a new product line of CyNexo, a recently established SISSA startup that operates in the market of laboratory equipment and is looking to expand its products’ package to videography tools.

Mots-clés : head tracking,eye tracking,instrumentation,smart camera,behavioral neurophysiology
Projet ERC : BIOLOCHANICS (Horizon 2020, appel 2014, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : Institut Mines-Télécom — Pays : France — Rôle : Partner
Acronyme de l'entité : IMT
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 485013.0 €

Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended to other soft tissues for applications in orthopaedics, oncology, sport biomechanics, interventional surgery, human safety, cell biology, etc.

Mots-clés : biomechanics,aortic aneurism,rupture,full field optical measurement,inverse methods,distribution of material properties,nonlocal mechanics,soft tissues
Projet ERC : SciFair (Horizon 2020, appel 2020, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : Université Libre de Bruxelles — Pays : Belgique — Rôle : Partner
Acronyme de l'entité : ULB
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

SCIFAIR aims to conduct pioneering research on the role itinerant showpeople played in the transmission and popularisation of science and technology at Western European fairgrounds between 1850 and 1914. At a time when modern communication media were not yet in place and only a minority of the population could read, large groups of people were actually dependent on travelling performances and displays for information: in so-called anatomical cabinets, zoological and anthropological museums and scientific theatres, showpeople demonstrated ‘wonders of nature’ and spectacular scientific developments. The project advances the hypothesis that the fair in this period was not merely a local folk tradition, but a hub for international exchange in which itinerant entertainment played a pivotal and modernising role in the circulation and popularisation of science amongst people across the social spectrum, relying on efficient international networks. In order to test this hypothesis, the project will bring together a multilingual and multidisciplinary team of researchers that will combine methodologies from theatre and performance studies with perspectives from history of science, media studies and digital humanities to analyse practices of science performance across national boundaries and map transnational networks of Western European fairground theatres. SCIFAIR will not only study explicit didactic discourses but also analyse how implicit knowledge and social values of health, gender, nation, class or race were challenged or reinforced. By analysing the fair as a performative event, the project will advance a conceptual shift in media historiography to a historiography of media performance and thus contribute to our understanding of the social and cultural role of the fair in knowledge circulation. SCIFAIR will thus make a major contribution to media and performance history, as well as to the history of science and knowledge transfer.

Mots-clés : media archaeology,fairground history,history of popular performance,history of popular culture and media