Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : DIPLOFACE (Horizon 2020, appel 2015, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : University of Cambridge — Pays : Royaume-Uni — Rôle : Partner
Acronyme de l'entité : U. Cambridge
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 78810.0 €

The rise of social media, coupled with intensifying demands for more transparency and democracy in world politics, brings new challenges to international diplomacy. State leaders and diplomats continue to react to traditional media, but now also attempt to present themselves proactively through tweets, public diplomacy and nation branding. These efforts often take place simultaneously and sometimes interfere directly with closed-door negotiations and its culture of restraint and secrecy. Yet the relationship between confidential diplomacy and public representation remains understudied. DIPLOFACE will develop a sociologically and anthropologically informed approach to studying how state leaders and diplomats manage their nation’s ‘faces’ in the information age. The project will explore the relationship and tensions between confidential diplomatic negotiations and publicly displayed interventions in various media, applying the micro-sociological concept of ‘face-work’. DIPLOFACE will analyse the complex interactional dynamics that shape the diplomatic techniques and strategies used to convey a nation’s ‘face’ or ‘image of self’. Such face-work is increasingly important for national leaders and diplomats who perform simultaneously on the ‘back-stage’ and the ‘front-stage’ of international relations. DIPLOFACE will identify, theorize and analyse the repertoire of face-saving, face-honouring and face-threatening practices that are employed in confidential negotiations and in public. DIPLOFACE advances our theoretical understanding of diplomacy in the 21st century significantly beyond existing International Relations and diplomatic theory. Combining participant observation, interviews and media analysis, DIPLOFACE will generate important new knowledge about the relationship between public and confidential multilateral negotiation, how state leaders and diplomats handle new media, and the role of face-saving and face-threatening strategies in international relations.
Projet ERC : EPIDEMIC (Horizon 2020, appel 2019, Starting grants)
Domaine scientifique : Life Science
Panel : Environmental Biology, Ecology and Evolution
Entité participante : University of Lausanne — Pays : Suisse — Rôle : Partner
Acronyme de l'entité : UNIL
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

The risks and impact of disease are exacerbated in social organisms, which live in dense groups wherein pathogens can rapidly propagate. Theoretical epidemiology predicts that disease dynamics will depend in large part on a group's social interaction network, but empirical data are scarce. Experimental epidemiology is currently hampered by a lack of study systems that would enable a rigorous investigation of the causal link between network structure and disease transmission. I will tackle this question using a novel system, the clonal raider ant, a social insect whose unique biology affords unparalleled control over the main aspects of colony composition that are thought to modulate social network structure, and therefore, disease transmission. My approach will combine cutting-edge automated techniques for behavioral tracking with molecular tools, and develop new methods to monitor transmission in real time. In a first step, I will create empirical networks that are theoretically predicted to vary in transmission risk and map individual immune function onto these networks, to measure the prophylactic network properties that might reduce disease transmission. Second, I will test if experimental increases in immune activity induce changes in behavior that are relevant for disease transmission, to measure inducible network properties. Finally, I will inoculate colonies with nematodes and quantify infection propagation in real time. This will allow me to compare various types of social networks (healthy, immune-activated, infected), to probe the link between behavior and immunity, and to experimentally test predictions from theoretical epidemiology. This project takes an integrative approach—from individual immunity to collective behavior—to uncover the properties of social groups that protect them against disease. By linking theoretical epidemiology to real-world disease dynamics, it will push the limits of our ability to predict disease dynamics in social groups.
Projet ERC : ImmunoBile (Horizon 2020, appel 2015, Advanced grants)
Domaine scientifique : Life Science
Panel : Physiology in Health, Disease and Ageing
Entité participante : Institut national de la santé et de la recherche médicale — Pays : France — Rôle : Partner
Acronyme de l'entité : Inserm
Type d'entité : Recherche
Financement ERC de l'entité : 525693.75 €

The role of chronic inflammation in obesity, metabolic and cardiovascular diseases is increasingly recognized. Bile acids (BA), synthesized in the liver and modified by the gut flora, facilitate lipid absorption in the intestine. BA modulate lipid and glucose homeostasis by activating the nuclear receptor FXR and the GPCR TGR5. Intriguingly, peripheral BA concentrations are elevated in type 2 diabetes (T2D) and FXR mediates the beneficial metabolic response to gastric bypass in mice. The immune system plays an important role in the cross-talk with metabolic tissues, such as liver, intestine and adipose tissues. However, whether BA modulate immune cell function is unknown. Our unpublished results identifying FXR and TGR5 expression in lymphoid cells, prompt us to study their role in the regulation of glucose and lipid metabolism through immune cell modulation. Using reporter mice and specific ligands, we will characterize the immune cells expressing active FXR and TGR5. We will determine their role in metabolism and inflammation by immune cell-specific gene inactivation in models of obesity, T2D and elevated peripheral blood BA concentrations. Mass cytometry, cell sorting and single cell transcriptomic analysis will allow the identification of gene networks regulated by BA and their receptors. As microbiota generate biologically active secondary BA, we will assess the impact of microbiota depletion and subsequent BA acid pool modifications on immune cell populations. Translational studies in humans with altered BA metabolism and pharmacological treatment with anti-diabetic BA sequestrants will allow assessment of alterations in immune functions. This project aims to identify an hitherto unexplored role of BA through modulation of the immune system on T2D, NAFLD and dyslipidemia. Success of the project critically depends on an integrative approach uniquely undertaken in my laboratory through its unique multidisciplinary expertise in basic and translational biology.

Mots-clés : bile acid,nuclear receptors,inflammation,lymphocytes,type 2 diabetes,obesity,liver diseases
Projet ERC : SPIRE (Horizon 2020, appel 2014, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Universe sciences
Entité participante : Commissariat à l’énergie atomique et aux énergies alternatives — Pays : France — Rôle : PI
Acronyme de l'entité : CEA
Type d'entité : Recherche
Financement ERC de l'entité : 1839633.77 €

The rotational dynamics of stars strongly impacts their evolution and those of their planetary and galactic environment. Space helio- and asteroseismology recently allowed an observational revolution in this domain. They revealed, e.g., that the core of the Sun is close to a uniform rotation while those of subgiant and red giant stars slow down drastically during their evolution. These important results demonstrate that powerful dynamical mechanisms (internal waves, magnetic fields, turbulence) are in action to extract angular momentum all along the evolution of stars. Simultaneously, a very large diversity of stellar systems has been discovered and their number will strongly increase thanks to new space missions (K2, TESS, PLATO). It is thus urgent to progress on our understanding of star-planet and star-star interactions: highly complex dynamical processes leading to tidal dissipation in stars play a key role to shape the orbital architecture of their systems and they may deeply modify their evolution. To interpret these observational breakthroughs, it is necessary to develop now new frontier theoretical and numerical long-term evolution models of rotating magnetic stars and of their systems. To reach this ambitious objective, the SPIRE project will develop new groundbreaking equations, prescriptions, and scaling laws that describe coherently all dynamical mechanisms that transport angular momentum and drive tidal dissipation in stars using advanced semi-analytical modeling and numerical simulations. They will be implemented in the new generation dynamical stellar evolution code STAREVOL and N-body code ESPER. This will allow us to provide state-of-the-art ab-initio integrated and coupled models for the long-term evolution of stars and of their systems, which cannot be directly simulated in 3D yet. SPIRE will thus provide key inputs for the whole astrophysical community: understanding the dynamics of stars is a fundamental step to understand our Universe.

Mots-clés : stars  rotation,stars  evolution,asteroseismology,stellar system interactions,waves,turbulence,tides
Projet ERC : AArteMIS (Horizon 2020, appel 2014, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : Université Grenoble Alpes — Pays : France — Rôle : Partner
Acronyme de l'entité : UGA
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 42937.5 €

The rupture of an Aortic Aneurysm (AA), which is often lethal, is a mechanical phenomenon that occurs when the wall stress state exceeds the local strength of the tissue. Our current understanding of arterial rupture mechanisms is poor, and the physics taking place at the microscopic scale in these collagenous structures remains an open area of research. Understanding, modelling, and quantifying the micro-mechanisms which drive the mechanical response of such tissue and locally trigger rupture represents the most challenging and promising pathway towards predictive diagnosis and personalized care of AA. The PI's group was recently able to detect, in advance, at the macro-scale, rupture-prone areas in bulging arterial tissues. The next step is to get into the details of the arterial microstructure to elucidate the underlying mechanisms. Through the achievements of AArteMIS, the local mechanical state of the fibrous microstructure of the tissue, especially close to its rupture state, will be quantitatively analyzed from multi-photon confocal microscopy and numerically reconstructed to establish quantitative micro-scale rupture criteria. AArteMIS will also address developing micro-macro models which are based on the collected quantitative data. The entire project will be completed through collaboration with medical doctors and engineers, experts in all required fields for the success of AArteMIS. AArteMIS is expected to open longed-for pathways for research in soft tissue mechanobiology which focuses on cell environment and to enable essential clinical applications for the quantitative assessment of AA rupture risk. It will significantly contribute to understanding fatal vascular events and improving cardiovascular treatments. It will provide a tremendous source of data and inspiration for subsequent applications and research by answering the most fundamental questions on AA rupture behaviour enabling ground-breaking clinical changes to take place.

Mots-clés : biomechanics,aneurysm,microstructure analysis,rupture criteria,numerical reconstruction,multiscale modeling
Projet ERC : L.I.F.E. (Horizon 2020, appel 2015, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Naples Federico II — Pays : Italie — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 445359.0 €

The scope of LIFE is to offer a complete set of archaeological and environmental data to be used to investigate Late Roman settlements along frontier desert areas and to reconstruct the underlying strategy to control the empire’s desert edges. The case study is the chain of Late Roman fortified settlements that punctuate the Kharga Oasis (Egypt’s Western Desert), that in the Fourth Century represented a portion of the southern boundary of the empire. All these sites, located in a remote and harsh environment, share the same architectural features and are endowed with similar agricultural installations, thus suggesting the existence of a highly motivated large-scale strategy of occupation of the region. A detailed study of Umm al-Dabadib, the best-preserved site, will produce a consistent set of criteria to be applied to the analysis of its less-preserved companions. In turn, a comprehensive study of these self-contained and self-sufficient settlements with a strong military flavour will allow a reconstruction of the Late Roman strategy of control over the desert routes that met in this oasis, and will offer an important contribution to the debate on the defence of the empire’s borders in the historical period from Diocletian to Constantine and beyond to the end of the Fourth Century. The sites will be studied using a combination of classic and innovative investigation techniques: 3D survey of the architectural remains, archaeological excavation of specific portions of both the built-up areas and the agricultural systems, archaeobotanical analyses, ceramic studies, analyses of satellite images, all carried out within the wider frame of an environmental study of the area and a historical analysis of the textual sources. The dissemination will take place both through the usual channels (publications on paper) and through an innovative information system accessible to scholars all over the world, which will fully exploit the potential of the latest survey technique.

Mots-clés : late roman period,late roman army,late roman forts,diocletian,constantine,egypt,kharga oasis,western desert,frontier,oases,caravan routes,agricultural systems,subterranean aqueducts
Projet ERC : BIOMAMA (Horizon 2020, appel 2020, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Universe sciences
Entité participante : Université d'Orléans — Pays : France — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1999746.0 €

The search for biologically driven alterations on Mars and its potential as habitat for past or present life is a primary aim of the upcoming Mars exploration missions. While a range of environments that would have been well suited to support a potential chemolithotrophy on Mars have been proposed, our understanding of putative biosignatures to be targeted in Martian materials is still poor. A valuable source of information can be extracted from microbial fingerprints of chemolithotrophic life based on Martian materials (Martian meteorites, regolith simulants). Chemolithotrophic microorganisms employ an astonishing number of metabolic pathways to extract energy from diverse inorganic electron donors/acceptors, shaping global biogeochemical cycles. Using a holistic approach based on laboratory, field and space exposure experiments, we propose to investigate interactions of Earth’s various chemolithoautotrophs with Martian materials. The bottom-up exploration of mineral-microbial interactions for different chemolithotrophs cultivated on Martian materials as the sole energy sources, will decipher mineral and metabolic biosignatures associated with these cases. This project explores unique microbial interactions with extraterrestrial materials down to the nanoscale and atomic resolution utilizing a comprehensive toolbox of cutting-edge techniques. BioMaMa will identify preservable biomarkers/biosignatures of chemolithotrophic life on Martian materials after the exposure to simulated Martian conditions at low Earth orbit and ground-based facilities. A complex approach will be used to investigate meteorite-microbial interactions in Mars-analogue sites on Earth. The extensive knowledge gained from BioMaMa will help to understand and critically interpret the results of future Mars exploration missions (ExoMars 2020). These studies will lay the foundation for efficient nanoanalytical spectroscopy of returned Mars samples, to critically assess their potential biogenicity.

Mots-clés : mars,meteorites,space missions,extremophiles,chemolithotrophs,biominerals,biosignatures
Projet ERC : SEACHANGE (Horizon 2020, appel 2019, Synergy grants)
Entité participante : University of Queensland — Pays : Australie — Rôle : Partner
Acronyme de l'entité : UQ
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 35807.5 €

The seas are changing. Marine conservation seeks to protect valuable habitats but the pristine state of marine ecosystem functioning and biodiversity – that is, the system as it operated before there was any large scale human impact – is conjectural. Conservation management strategies are often based on highly altered ecosystems where the degree of human-induced change is unknown. In SEACHANGE, we propose a structured and systematic approach to the reconstruction of marine ecosystem baselines to quantify the impact of anthropogenic cultural transitions on marine biodiversity and ecosystem functioning. SEACHANGE will address two key questions: 1) What was the nature of long-term changes in prehistoric marine biodiversity and ecosystem functioning over a 3000-year period in NW Europe and the degree of human impact associated with major socioeconomic changes across the Mesolithic-Neolithic boundary? 2) What has been the scale and rate of marine biodiversity loss and changes to ecosystem functioning as a result of fishing intensity and marine habitat loss during the last 2000 years (including the Industrial Transition) in the North Sea and around Iceland, eastern Australia and the west Antarctic Peninsula? To address these questions we will analyse: 1) absolutely-dated annually-resolved bivalve shell series (“sclerochronologies”); 2) marine sediment cores; 3) archaeological midden (waste) materials including shells and bones. We will date these samples precisely and undertake zooarchaeological and palaeoecological, stable isotope geochemical and environmental DNA/DNA metabarcoding analyses. We will compare the data with historical and archival sources, and we will generate numerical ecosystem simulations. We will identify how depleted the current marine environment is compared with that before large scale human impact and what measures are needed, and how long will it take, for marine biodiversity to recover.

Mots-clés : marine palaeoevironments,holocene,marine ecosystems,marine biodiversity,environmental change,cultural transition,sclerochronology,marine environmental archaeology,midden
Projet ERC : SEACHANGE (Horizon 2020, appel 2019, Synergy grants)
Entité participante : University of Copenhagen — Pays : Danemark — Rôle : PI
Acronyme de l'entité : UCPH
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 3061523.18 €

The seas are changing. Marine conservation seeks to protect valuable habitats but the pristine state of marine ecosystem functioning and biodiversity – that is, the system as it operated before there was any large scale human impact – is conjectural. Conservation management strategies are often based on highly altered ecosystems where the degree of human-induced change is unknown. In SEACHANGE, we propose a structured and systematic approach to the reconstruction of marine ecosystem baselines to quantify the impact of anthropogenic cultural transitions on marine biodiversity and ecosystem functioning. SEACHANGE will address two key questions: 1) What was the nature of long-term changes in prehistoric marine biodiversity and ecosystem functioning over a 3000-year period in NW Europe and the degree of human impact associated with major socioeconomic changes across the Mesolithic-Neolithic boundary? 2) What has been the scale and rate of marine biodiversity loss and changes to ecosystem functioning as a result of fishing intensity and marine habitat loss during the last 2000 years (including the Industrial Transition) in the North Sea and around Iceland, eastern Australia and the west Antarctic Peninsula? To address these questions we will analyse: 1) absolutely-dated annually-resolved bivalve shell series (“sclerochronologies”); 2) marine sediment cores; 3) archaeological midden (waste) materials including shells and bones. We will date these samples precisely and undertake zooarchaeological and palaeoecological, stable isotope geochemical and environmental DNA/DNA metabarcoding analyses. We will compare the data with historical and archival sources, and we will generate numerical ecosystem simulations. We will identify how depleted the current marine environment is compared with that before large scale human impact and what measures are needed, and how long will it take, for marine biodiversity to recover.

Mots-clés : marine palaeoevironments,holocene,marine ecosystems,marine biodiversity,environmental change,cultural transition,sclerochronology,marine environmental archaeology,midden
Projet ERC : SEACHANGE (Horizon 2020, appel 2019, Synergy grants)
Entité participante : University of York — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1828990.88 €

The seas are changing. Marine conservation seeks to protect valuable habitats but the pristine state of marine ecosystem functioning and biodiversity – that is, the system as it operated before there was any large scale human impact – is conjectural. Conservation management strategies are often based on highly altered ecosystems where the degree of human-induced change is unknown. In SEACHANGE, we propose a structured and systematic approach to the reconstruction of marine ecosystem baselines to quantify the impact of anthropogenic cultural transitions on marine biodiversity and ecosystem functioning. SEACHANGE will address two key questions: 1) What was the nature of long-term changes in prehistoric marine biodiversity and ecosystem functioning over a 3000-year period in NW Europe and the degree of human impact associated with major socioeconomic changes across the Mesolithic-Neolithic boundary? 2) What has been the scale and rate of marine biodiversity loss and changes to ecosystem functioning as a result of fishing intensity and marine habitat loss during the last 2000 years (including the Industrial Transition) in the North Sea and around Iceland, eastern Australia and the west Antarctic Peninsula? To address these questions we will analyse: 1) absolutely-dated annually-resolved bivalve shell series (“sclerochronologies”); 2) marine sediment cores; 3) archaeological midden (waste) materials including shells and bones. We will date these samples precisely and undertake zooarchaeological and palaeoecological, stable isotope geochemical and environmental DNA/DNA metabarcoding analyses. We will compare the data with historical and archival sources, and we will generate numerical ecosystem simulations. We will identify how depleted the current marine environment is compared with that before large scale human impact and what measures are needed, and how long will it take, for marine biodiversity to recover.

Mots-clés : marine palaeoevironments,holocene,marine ecosystems,marine biodiversity,environmental change,cultural transition,sclerochronology,marine environmental archaeology,midden