Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : MORPHEUS (Horizon Europe, appel 2021, Consolidator grants)
Domaine scientifique : Life Science
Panel : Cell Biology, Development, Stem Cells and R egeneration
Entité participante : Société Max-Planck pour le développement des sciences — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : Société Max Planck
Type d'entité : Recherche
Financement ERC de l'entité : 2000000.0 €

The implantation of the blastocyst into the uterine wall is a key step of the reproductive cycle, which mediates the connection of the embryo to the maternal tissues during the early stages of pregnancy. However, in some species, including the house mouse, this process can be put on hold, while the embryo falls into a reversible state of suspended animation, known as diapause. The dormant embryos can reside in a “deep sleep” over extended periods of time (e.g. bypassing unfavourable environmental conditions), without compromising their developmental potential. Although, the maternal hormonal control of implantation and the process of transient mouse embryogenesis have been intensively studied, the embryonic diapause is still an extremely enigmatic state. Several lines of evidence, based on my preliminary data, suggest that diapause is not a stasis, but instead is a dynamic process with underlying mechanisms that can appear redundant during transient embryogenesis. Here I aim to decipher the cryptic embryo-intrinsic mechanisms of embryo dormancy, using the mouse as a model system. I will elucidate the cellular processes that coordinate and capacitate the embryo for diapause on epigenetic, transcriptional and cell signalling levels. Using interspecies chimeras and blastoids, I will extend my analysis to non-diapausing species and artificial embryo-like structures. Thus, by manipulating the flow of embryogenesis, I will uncover hidden, dormant mechanisms, safeguarding the developmental potential of the early mammalian embryo.

Mots-clés : embryo dormancy,diapause,blastocyst
Projet ERC : DIGINEQ (Horizon Europe, appel 2022, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The Soci al World and Its Interactions
Entité participante : CERCA Institution — Pays : Espagne — Rôle : Partner
Acronyme de l'entité : CERCA;I-CERCA
Type d'entité : Recherche
Financement ERC de l'entité : 253009.3 €

In our highly unequal and digitalised world, understanding how adolescents’ digital lives intersect with social inequalities is critical. Research has consistently shown that adolescents from privileged socioeconomic backgrounds are advantaged in their academic, health and socioemotional outcomes. However, how adolescents’ digital engagement relates to social inequalities in well-being is poorly understood. DIGINEQ significantly contributes to close this major scientific gap. The project applies an innovative 24-hour time-use approach that brings a complex understanding of how exactly adolescents’ digital time use shapes social inequalities in well-being in daily life. DIGINEQ has three main objectives:  1. To understand how changes in digital engagement from childhood to late adolescence explain socioeconomic disparities in well-being outcomes. 2. To disentangle how exactly adolescents’ digital time use forms social inequalities in their well-being in everyday life. 3. To establish if digital interventions can promote adolescents’ healthy digital engagement and improve well-being outcomes, while reducing socioeconomic gaps in these areas. By adopting a novel approach that combines multiple disciplines and methodologies, this project brings three major scientific innovations: (1) it creates an innovative method based on mobile-app data to accurately track adolescents’ exact digital time use and measure socioeconomic gaps in well-being in real time; (2) it implements a novel mixed-method digital intervention to show if digital self-efficacy programmes can promote adolescents’ healthy digital engagement and improve well-being outcomes, while reducing related socioeconomic gaps; (3) it merges existing high-quality longitudinal time-diary data from three largescale surveys in Australia, Ireland, and the United States to illustrate how adolescents’ digital time use explains socioeconomic gaps in well-being from childhood to late adolescence.

Mots-clés : time use social inequalities adolescent well being screen time quantitative sociology
Projet ERC : LIFELONGMOVE (Horizon Europe, appel 2021, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Human Mobility, Environment, and Space
Entité participante : CERCA Institution — Pays : Espagne — Rôle : Partner
Acronyme de l'entité : CERCA;I-CERCA
Type d'entité : Recherche
Financement ERC de l'entité : 146035.0 €

The LIFELONGMOVE project is the first of its kind to comprehensively and systematically examine spatial mobility from early age into adulthood (i.e. lifelong mobility).  Research has only started to address the increasingly diverse and complex ways individuals engage in spatial mobility over the life course, and in relation to the growing inequality of opportunity. While backgrounds and circumstances in childhood shape life chances and outcomes in a later age, the extent to which childhood mobility contributes to diversity in life paths and stratified outcomes in adulthood is largely unknown.  LIFELONGMOVE brings together and integrates bodies of research that study spatial mobility in childhood and in adulthood separately, and provides new insight on the pathways, resources, and strategies that underlie lifelong mobility. This insight will help formulate alternatives to the conventional explanations of spatial mobility patterns, behaviours, and stratified outcomes over the life course.  LIFELONGMOVE has three main innovative objectives: (i) to document the diverse and complex pathways of lifelong mobility (by examining long-term trajectories from early childhood into adulthood); (ii) to establish whether (and how) childhood mobility influences spatial mobility over the life course; and (iii) to document the impact of lifelong mobility on life conditions, by focusing on socio-economic, family, and health outcomes. To address these objectives, LIFELONGMOVE innovates by adopting a novel approach that recognizes the experiences and resources accumulated since an early age that underlie the rationales, opportunities, and restrictions for mobility behaviour, and their associated outcomes in a later age. LIFELONGMOVE breaks new ground by examining large-scale longitudinal datasets from integrated administrative registers and panel surveys that recently enabled this study for a range of European contexts, using a series of advanced quantitative methods.
Projet ERC : BiASE-AI (Horizon Europe, appel 2024, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Zeppelin Universität — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : ZU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1954746.0 €

Artificial intelligence (AI) holds the potential to assist or even replace civil servants in citizen-state interactions, which refer to those instances in which citizens seek or receive assistance, information, or support from a public agency. In Germany alone, around 130 to 150 million such public service encounters (PSE) occur each year, with the current proportion of digital encounters, facilitated through email or chatbots, standing at 41 percent. This is only the beginning of a revolution that will accelerate due to technological innovation and scarcity in human resources. The goal of this project is to study the consequences of shifting from human to AI-powered conversational agents in PSE. Paradoxically, while the transition to artificial encounters is already taking place in practice, we still lack understanding of what happens during conventional human encounters. This prevents researchers from evaluating the consequences of shifting from one venue to the other. Therefore, the project’s main research questions are: How can we conceptualize and measure communicative biases in PSE? What biases emerge in the verbal communication of humans and AI agents in PSE? How does variation in communication affect citizen perceptions of the encounter? AI has the potential to improve service delivery, but there are also risks for the legitimacy of democracy. Without further research, the introduction of AI threatens to merely shift biases from one venue (civil servants) to another (AI agent). As its ground-breaking contributions, the project (1) develops natural language processing tools to operationalize verbal communication; (2) collects data from human encounters in PSE and realizes experiments on AI-based encounters; (3) and analyses such data to formulate and test a theory about communicative biases in PSE. Doing so, (4) the project will produce and disseminate urgently needed practical insights on the application of AI conversational agents in the public sector.
Projet ERC : DEMOLAW (Horizon Europe, appel 2023, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Zeppelin Universität — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : ZU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1974936.0 €

Democracies are constantly confronted with the challenging task of merging widely diverging worldviews, interests and values into coherent legislation. Given the increasingly hostile political climate around the world, solving this task has never been more difficult and more important than today. Yet, despite the crucial relevance of laws for our daily lives and the legitimacy and effectiveness of democratic government, our understanding of how the design, creation and long-term survival of legislation are related is still very limited.  The DEMOLAW project analyses legislative texts in three different political systems (US, UK, EU) with cutting-edge computational methods to answer three major research questions: (1) Which conceptual dimensions capture the design of a law and how can we exploit textual properties of law texts to measure these dimensions empirically? (2) Why does the design of democratic legislation vary across laws, policy domains and political systems? (3) How can we explain why some laws are entirely stable over time, while others are constantly adjusted and sometimes transformed fundamentally?  The project makes three major contributions. First, it provides an entirely novel conceptual perspective on the design of democratic laws by focusing on two analytical dimensions that are central to any piece of legislation: versatility and precision. This innovative approach allows us, for the first time, to measure and compare the substance of legislative output across and within policy domains, political systems and over time. Second, the project will develop and test an integrated theoretical framework on both the creation and the survival of democratic legislation and thereby advance the theoretical state-of-the-art in comparative public policy. Finally, the project’s ground-breaking methodological approach will pave the way for a computational analysis of legislative content and will thereby push the boundaries of how we study democratic decision-mak

Mots-clés : comparative public policy,computational social science,democracy,law,legislation,policy design,political institutions,text as data
Projet ERC : PERIODS (Horizon Europe, appel 2024, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Wageningen University & Research — Pays : Pays-Bas — Rôle : PI
Acronyme de l'entité : WUR
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1999736.0 €

The period emoji, the year of the period, and an Oscar-winning documentary—with menstruation gaining attention at all levels, PERIODS explores the promises, pitfalls, and renewed potential of human rights in the menstrual movement. While research, policy, and practice on menstruation to date largely focus on tangible, material needs and risk leaving menstrual stigma and its role in perpetuating gender injustices intact, PERIODS recognizes that menstrual stigma and unmet menstrual needs have profound effects on the human rights to health, bodily integrity, education, work, and participation in social, cultural, and public life. The project centers the social practice of human rights in the menstrual movement by drawing on the articulations of lived experiences of people who menstruate and perspectives of movement leaders. It will examine if social movements reframe how human rights related to menstruation are understood and if so, how they move beyond the dominant reductionist framings in favor of a holistic, inclusive, and expansive conceptualization of human rights. The project combines empirical research using in-depth interviews, focus groups, qualitative surveys, and document analysis with conceptual work grounded in human rights. Theoretically, the project is rooted in the critical engagement with human rights and a re-envisioning of human rights ‘from below'. It considers the practice of human rights in the menstrual movement as constitutive of what matters for the realization and conceptualization of human rights. By connecting global and local struggles and movements in the global South and North, PERIODS will not only develop a thicker, more nuanced understanding of human rights in the menstrual movement, but also has the potential to generate significant empirical insights from a young, translocal, global South-driven movement for the reconceptualization of human rights based on social practice.

Mots-clés : menstruation menstrual health gender justice
Projet ERC : LIFELONGMOVE (Horizon Europe, appel 2021, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Human Mobility, Environment, and Space
Entité participante : Université autonome de Barcelone — Pays : Espagne — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1549947.5 €

The LIFELONGMOVE project is the first of its kind to comprehensively and systematically examine spatial mobility from early age into adulthood (i.e. lifelong mobility).  Research has only started to address the increasingly diverse and complex ways individuals engage in spatial mobility over the life course, and in relation to the growing inequality of opportunity. While backgrounds and circumstances in childhood shape life chances and outcomes in a later age, the extent to which childhood mobility contributes to diversity in life paths and stratified outcomes in adulthood is largely unknown.  LIFELONGMOVE brings together and integrates bodies of research that study spatial mobility in childhood and in adulthood separately, and provides new insight on the pathways, resources, and strategies that underlie lifelong mobility. This insight will help formulate alternatives to the conventional explanations of spatial mobility patterns, behaviours, and stratified outcomes over the life course.  LIFELONGMOVE has three main innovative objectives: (i) to document the diverse and complex pathways of lifelong mobility (by examining long-term trajectories from early childhood into adulthood); (ii) to establish whether (and how) childhood mobility influences spatial mobility over the life course; and (iii) to document the impact of lifelong mobility on life conditions, by focusing on socio-economic, family, and health outcomes. To address these objectives, LIFELONGMOVE innovates by adopting a novel approach that recognizes the experiences and resources accumulated since an early age that underlie the rationales, opportunities, and restrictions for mobility behaviour, and their associated outcomes in a later age. LIFELONGMOVE breaks new ground by examining large-scale longitudinal datasets from integrated administrative registers and panel surveys that recently enabled this study for a range of European contexts, using a series of advanced quantitative methods.
Projet ERC : HUMPH (Horizon Europe, appel 2024, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Systems and Communication Engineering
Entité participante : Université de Lund — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2595237.0 €

This project will push the limits of microscale ultrasound-based technology to detect and gain access to diagnostically interesting, rare cells in the blood based on a panel of acousto-mechanical properties. Microscale systems are powerful tools to examine and manipulate single cells. In addition, the high precision and potential for multi-stage serial processing offered by such microfluidic methods open up for isolation of rare cell populations, such as circulating tumor cells, and controlled size fractionation of sub-micron biological particles, such as platelets, bacteria, or extracellular vesicles.  To achieve highly specific single-cell isolation of target cells, we will expose blood to acoustic radiation forces in a flow-through format enabling multiparameter characterization of thousands of cells. Based on this, new separation schemes will be developed that can isolate extremely rare circulating tumor cells from the blood of patients with prostate cancer. The project will render new fundamental knowledge regarding the mechanical properties of single cells and a framework to understand the response of cells to any aqueous medium, bounding geometry and sound field, and new tools to better understand the role of circulating tumor cells in metastasizing cancer as well as analyzing them for diagnosis and treatment guidance.

Mots-clés : pacs2010 43 25 nm acoustic streaming 43 25 qp radiation pressure 43 40 rj radiation from vibrating structures into fluid media 47 35 rs sound in fluids 43 35 ud thermoacoustics,high temperature acoustics,photoacoustic effect
Projet ERC : RESISTANCEPROGRAMS (Horizon Europe, appel 2021, Consolidator grants)
Domaine scientifique : Life Science
Panel : Prevention,  Diagnosis and T reatment of Human Diseases
Entité participante : Université de Lund — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1999444.0 €

Gliomas are the most common brain tumors and the highest-grade glioma, glioblastoma (GBM), is arguably the most aggressive tumor type, with no long-term survivors. Patients with GBM are treated with radiotherapy, chemotherapy, surgery, and tumor treating fields. Despite initial response all tumors recur as incurable lesions; there is an urgent need for novel therapeutic approaches for this patient group. The majority of GBMs recur within the treatment field receiving high-dose radiotherapy during treatment of the primary tumor; the recurrent tumor thus forms in an irradiated microenvironment. Despite the fact that it is the recurrent tumor that ultimately kills the patient and that the majority of new therapeutic agents for GBM are tested clinically in the recurrent setting, the majority of experimental models and clinical materials for drug discovery are based on primary disease. Recent advances established a central role for the tumor microenvironment in determining the therapeutic response of GBM cells, and our lab demonstrated that standard of care radiotherapy of the primary tumor can shape the microenvironment to generate tumor-supportive conditions in the recurrent tumor; These findings suggest that there is untapped potential in targeting the irradiated microenvironment. This proposal aims to explore and exploit the recurrent brain tumor microenvironment by i) consolidating the contribution of the irradiated brain tumor microenvironment to GBM resistance by integrating spatial transcriptomics, single cell RNA sequencing, and multiplexed immunohistochemistry from state-of-the-art murine and human models of GBM treatment and recurrence, and ii) discovering and targeting novel therapeutic targets unique to the post-radiotherapy brain tumor microenvironment by high-throughput phenotypic screening, with the ultimate goal of exploiting reversible stromal radiation responses and leverage novel therapeutic opportunities unique to the irradiated brain.

Mots-clés : tumor microenvironment,therapeutic resistance,brain tumors,radiotherapy
Projet ERC : AXES.Histo (Horizon Europe, appel 2022, Consolidator grants)
Domaine scientifique : Life Science
Panel : Prevention,  Diagnosis and T reatment of Human Diseases
Entité participante : Université de Lund — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2000000.0 €

In the last 20 years, phase-contrast x-ray imaging has evolved from first proof-of-principle experiments with relatively poor contrast, to a mature research field with many branches. Standing on the shoulders of scientific achievements and technological development, the time has come where virtual histology for biomedical applications is within reach. The aim of this research project is to design and construct a prototype x-ray microscope for three-dimensional histology. In the clinics we are used to non-invasive three-dimensional image modalities such as e.g. computed tomography (CT), ultrasound and magnetic resonance imaging (MRI). The ability to visualise and track structures through a volume is extremely valuable for the purpose of diagnosis. But for microscopy of tissue biopsies, our golden standard is histological procedures involving thin slicing of the tissue before imaging in a microscope, rendering volumetric interpretation very difficult of not impossible. With the proposed phase-contrast micro-CT scanner, tissue samples can be imaged in three dimensions such that the computer rendering of the sample can be sliced in any arbitrary plane, and we have the possibility of volumetric data analysis. In this fashion, useful volumetric information can be extracted for various applications in biomedical research. As a direct application, we will use this 3D Histology setup to obtain detailed volumetric understanding of the development of lung lesions, and complement with gold standard microscopy techniques. A lab-based setup for virtual histology will allow full studies of disease pathologies with statistical significance and make optimisation of experimental protocols possible. For achieve the goal of soft tissue micro-CT, we will implement a novel inverse-geometry single-grating interferometer. When combined with state-of-the-art detector and source technology a scanner for high-resolution phase-contrast tomography of soft tissue will be realised.

Mots-clés : x ray wave propagation x ray phase contrast imaging 3d histology