Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : Andrea (Horizon 2020, appel 2018, Proof of concept grants)
Entité participante : Slovak Academy of Sciences — Pays : Slovaquie — Rôle : PI
Acronyme de l'entité : SAS;SAV
Type d'entité : Recherche
Financement ERC de l'entité : 87500.0 €

The technology validation was successfully completed indicating a great commercial potential, and the innovative and inventive aspects of the assay platform are now covered by the filed priority European Patent Office (EPO) patent applications. Validated glycoprofiling of the proteins now uses lectins in a format, fully compatible with clinical PSA assay kits. This PoC grant focuses on 1. Pre-clinical retrospective validation of the early stage biomarker of prostate cancer (PCa) and 2. Commercialisation of the PCa diagnostics kit. Pre-clinical (60 human serum samples) is ongoing and retrospective validation study (450 human serum samples) of the assay will be performed by statistical analysis using a receiver operating characteristic (ROC) curve. The PoC describes all steps, which have been developed so far and all necessary steps, which need to be done for retrospective validation study, product development and commercialisation through our newly incorporated start-up Glycanostics Ltd. (www.glycanostics.com). We will provide PCa diagnostic test resulting in a second opinion to guide the right decision if the biopsy is needed. This will avoid the needless and unreliable biopsies and in the future rival an inaccurate PSA testing.

Mots-clés : prostate cancer,diagnostics,biomarkers,glycans,lectins,assay kit
Projet ERC : GC2.0 (Horizon 2020, appel 2015, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Earth system science
Entité participante : University of Reading — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2497563.0 €

The terrestrial biosphere responds rapidly and sensitively to climate change and is important in mediating physical and biogeochemical feedbacks to climate. There are still enormous uncertainties in our understanding of how the terrestrial biosphere will respond to changes in climate in the 21st century, and large uncertainties in predictions of the climate feedbacks. Many issues that limit our ability to predict the future of the terrestrial biosphere can be addressed by examining what happened in the recent geologic past – where the drivers of climate change are relatively well known and there is abundant globally-distributed, quantitative, well-dated and unambiguous evidence of the biospheric response. The goal of this project is to unleash the power of the palaeo-record to understand the interactions of climate and the terrestrial biosphere, and to explain how terrestrial systems (vegetation, fire, hydrology, biogeochemical cycles including the carbon, trace gas and dust cycles) respond and contribute to long-term (millennial) and rapid (decadal to centennial) climate changes. I will use process-based models with global palaeodata syntheses to address four specific challenges to our understanding of past and future climate and environmental change: (1) How does vegetation respond to rapid climate change and what are the consequences of this response for climate? (2) To what extent does increasing CO2 enhance tree growth or competitive fitness, and how does this translate into changes in ecosystems and ecosystem services? (3) How does the terrestrial biosphere respond to changes in climate variability and the prevalence of extreme events? (4) How does the land surface affect regional climates, and why do models persistently fail to predict these effects accurately? In addressing these challenges, I will deliver public-access data sets, model outputs and comparison tools so the strengths of the palaeorecord can be exploited by the wider global change commun
Projet ERC : SMOOTH (Horizon 2020, appel 2019, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : University of Bologna — Pays : Italie — Rôle : PI
Acronyme de l'entité : UNIBO
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1130587.25 €

The threat of climate change calls for a rapid transition to a low-carbon society. Aligning the financial system with climate stability is a crucial prerequisite for achieving decarbonisation while preserving economic prosperity and societal welfare. However, we currently lack a comprehensive understanding of how the institutional and behavioural features of financial systems may affect the speed and shape of the low-carbon transition. Additionally, the coevolving socioeconomic, financial and environmental repercussions of such a large-scale societal transformation have not yet been systematically analysed. The SMOOTH project will lay the foundations of an innovative macro-financial analytical framework to provide essential insights on the links between financial systems and decarbonisation dynamics. Methodologically, I will introduce a breakthrough by linking macroeconomic analysis with an original evidence-based representation of investment decisions based on forward-looking expectations of transition pathways. In the course of five years, this integrated modelling framework will enable the first comprehensive assessment of the transition financial drivers and obstacles, and their implications for growth, financial stability, employment, private/public debt and functional distribution, with a focus on Europe. Building on this knowledge, a harmonised set of policies aimed at achieving a rapid and smooth transition can be designed. I will go beyond the current state of the art by integrating the analysis of fiscal policies with monetary policies and financial regulation, and investigating their institutional requirements and implications. SMOOTH will create a new interdisciplinary field of research integrating elements from macroeconomic modelling, climate economics, behavioural finance, socio-technical transition theory and political science, lifting the analytical power of transition modelling to a new level and opening up novel avenues for future research.

Mots-clés : low carbon transition,decarbonisation pathways,sustainable finance,climate related financial risks,stranded assets,macroeconomic modelling,expectations,behavioural finance,planning horizon,investment decisions,central banking,financial regulation,policy design,political economy
Projet ERC : CHROMDOM (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Life Science
Panel : Molecules of Life: Biological Mechanisms, Structures and Functions
Entité participante : Ludwig-Maximilians-Universität München — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : LMU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499350.0 €

The three-dimensional organization of chromosomes is necessary for hereditary fidelity and gene regulation. Recent studies have found that eukaryotic interphase chromosomes are spatially organized in compartments, chiefly topologically associated domains (TADs), in a hierarchical order of nested chromatin loops, coining the term “chromosome folding”. TADs are clusters of genes and regulatory elements that are confined to their genomic compartment by spatially constricting their accessible range of action. The folded structure of chromosomes through long-range loops enables mutual interactions of distant genomic loci that otherwise would not be in contact. While crosslinking-based chromosome conformation capture (3C) techniques have revealed the underlying structure of interphase chromosomes, the molecular mechanism of how chromosome-organizing proteins, such as the insulator CTCF or the structural maintenance of chromosomes (SMC) complex cohesin build the chromosomal scaffold and contribute to genomic organization, is not understood. Due to the complexity of the processes involved, biochemical information on how chromosomal proteins contribute to the establishment of TADs is scarce. I have previously demonstrated that single molecule techniques can be used to study the interactions of single cohesin complexes with DNA, chromatin and DNA-bound proteins and to resolve processes that are inaccessible in bulk biochemical experiments. In this project, I will use and expand the high-throughput single molecule technique of DNA curtains to study the molecular details of how chromosomal scaffolding proteins and genetic insulators form the basis for the three-dimensional folding of chromosomes. My experiments will build a novel experimental platform to study the dynamics of chromosomal configuration and maintenance in a reconstituted single molecule assay and will reveal the molecular details that drive the organization of chromosomes into hierarchically organized structures.
Projet ERC : 1stProposal (Horizon 2020, appel 2014, Advanced grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Mathematics
Entité participante : University of London — Pays : Royaume-Uni — Rôle : PI
Acronyme de l'entité : U. London
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2011742.0 €

The traditional (Riemann) approach to analytic number theory uses the zeros of zeta functions. This requires the associated multiplicative function, say f(n), to have special enough properties that the associated Dirichlet series may be analytically continued. In this proposal we continue to develop an approach which requires less of the multiplicative function, linking the original question with the mean value of f. Such techniques have been around for a long time but have generally been regarded as “ad hoc”. In this project we aim to show that one can develop a coherent approach to the whole subject, not only reproving all of the old results, but also many new ones that appear inaccessible to traditional methods. Our first goal is to complete a monograph yielding a reworking of all the classical theory using these new methods and then to push forward in new directions. The most important is to extend these techniques to GL(n) L-functions, which we hope will now be feasible having found the correct framework in which to proceed. Since we rarely know how to analytically continue such L-functions this could be of great benefit to the subject. We are developing the large sieve so that it can be used for individual moduli, and will determine a strong form of that. Also a new method to give asymptotics for mean values, when they are not too small. We wish to incorporate techniques of analytic number theory into our theory, for example recent advances on mean values of Dirichlet polynomials. Also the recent breakthroughs on the sieve suggest strong links that need further exploration. Additive combinatorics yields important results in many areas. There are strong analogies between its results, and those for multiplicative functions, especially in large value spectrum theory, and its applications. We hope to develop these further. Much of this is joint work with K Soundararajan of Stanford University.

Mots-clés : multiplicative functions,l functions
Projet ERC : SpoKiGen (Horizon 2020, appel 2014, Consolidator grants)
Domaine scientifique : Life Science
Panel : Environmental Biology, Ecology and Evolution
Entité participante : Uppsala University — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2000000.0 €

The traditional view of the genome is that of a highly coordinated network that has evolved to produce a successful individual. However, the alternative view of the genome as containing intrinsically conflicting parts that coevolve antagonistically, has recently emerged. Today, it is widely accepted that conflicts caused by selfish genetic elements is a driving force for evolutionary innovation, and hence, is of fundamental importance for all aspects of evolution. Nevertheless, empirical data on the topic is largely lacking. Here, I introduce the fungus Neurospora as a novel study system of the evolutionary significance of meiotic drive. In this sexual eukaryote model system, the meiotic drive element Spore killer is found. The cytological properties and natural distribution of Spore killing in Neurospora has been investigated for several decades, and preliminary data suggests that it is an important driver of both genome evolution and of higher-order evolutionary processes. The existing knowledge and resources of this system provide a foundation for the proposed research program, in which I plan to build a tool-kit of genomic and experimental resources to I) identify and characterize the gene(s) encoding Spore killer elements, II) assess the strength of Spore killer as a meiotic drive, III) unravel the evolutionary history of the Spore killer complex in Neurospora, IV) investigate the association between Spore killer and genome evolution, and V) analyze the role of Spore killer as a driver of speciation and mating system transitions. This research program will manifest the Spore killer as a primary and pioneering model for the study of meiotic drive, and profoundly impact our understanding of segregation distorters as drivers of eukaryote genome evolution. Furthermore, insights emerging from the project presented are conceptually important for basic evolutionary biology, in the study of natural selection acting at multitudinal levels in a biological hierarchy.

Mots-clés : genomic conflict,multilevel selection,fungi,genome evolution
Projet ERC : TWIST (Horizon 2020, appel 2019, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Synthetic Chemistry and Materials
Entité participante : Heidelberg University — Pays : Allemagne — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1047863.56 €

The translation of chirality from molecular to bulk inorganic systems opens many possibilities for new phenomena. The properties of chiral electronic states are interesting scientifically and attractive for applications. While optoelectronic properties of semiconductors are controlled by charge, magnetic materials function by spin. If a material can combine these functionalities, powerful novel applications and large gains in performance are possible in opto-spintronics. Yet, existing magnetic semiconductors often show lower optoelectronic quality or work at low temperature. Development of new systems is a scientific challenge due to the required coordination of spins and control of physical properties of excited states, while minimizing defects. TWIST will demonstrate novel highly-luminescent semiconductors for spin-control and chiral emission that show combined properties of ferromagnets and excellent semiconductors for efficient spin-LEDs at room temperature. To achieve this, TWIST will develop new approaches to control spin and chirality in doped metal-halide perovskites (MHPs) with magnetic elements and molecules, also in chiral superstructures. In 2014, I reported that MHPs are exceptionally bright emitters, which underpins their tolerance to defects and chemical variation, and which recently enabled remarkable doping with transition-metals. Optical spin-control and chiral emission are possible from spin-orbit coupling and Rashba effects, which will enhance spin-order for Curie temperatures towards room temperature. These exceptional properties of MHPs, which have already produced efficient solar cells and LEDs, provide now a unique opportunity for my project. TWIST will use state-of-the art optical and electronic techniques to unravel the fundamental mechanisms how magnetic moments, light and chiral states order and interact in MHPs. The results of TWIST will instigate opto-spintronic applications with novel functionality and lower energy consumption.

Mots-clés : dilute magnetic semiconductors,sustainable materials,chirality,magnetism,optoelectronics,high resolution ultrafast spectroscopy
Projet ERC : MACROPMF (Horizon 2020, appel 2015, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Individuals, Markets and Organisations
Entité participante : Einaudi Institute for Economics and Finance — Pays : Italie — Rôle : PI
Acronyme de l'entité : EIEF
Type d'entité : Recherche
Financement ERC de l'entité : 1192000.0 €

The transmission of microeconomic and macroeconomic shocks to firms' price and demand in product markets is the cornerstone of a large volume of macroeconomic literature. Product market frictions, by reducing the ability of demand to relocate across different suppliers, affect firms' incentives when setting prices, and therefore the pass-through of shocks to both demand and prices. In this project we plan to study the implications of product market frictions for firm level price and demand dynamics, as well as for macroeconomic dynamics. The aim is to integrate micro and macro economics, both theoretically and empirically, to a greater extent than is currently done in the literature. We will apply our tools to two main areas of interest. First, we will study how product market frictions affect the optimal pricing decision of firms, and the relocation of consumers across different suppliers. We will provide novel empirical microeconomic evidence on the relationship between price and consumer dynamics. We will build a rich but yet tractable model where product market frictions give rise to firm pricing with customer markets. The aim is to use observable statistics from the micro data to estimate the key parameters of the model and quantify the relevance of the product market frictions for firm pricing and demand dynamics. Second, we will explore the importance of product market frictions for macroeconomic dynamics. We will apply our quantified model of price and consumer dynamics to areas of macroeconomics where we expect our methodology and empirical analysis to be more relevant, both because of the types of questions addressed and because of a direct relationship with the mechanism. In particular we will focus on the role of product market frictions for business cycle fluctuations and international trade.

Mots-clés : product market frictions,price setting,business cycles
Projet ERC : ARTECHNE (Horizon 2020, appel 2014, Consolidator grants)
Domaine scientifique : Social Sciences and Humanities
Panel : The study of the human past
Entité participante : University of Amsterdam — Pays : Pays-Bas — Rôle : Partner
Acronyme de l'entité : UvA
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 103055.0 €

The transmission of ‘technique’ in art has been a conspicuous ‘black box’ resisting analysis. The tools of the humanities used to study the transmission of ideas and concepts are insufficient when it comes to understanding the transmission of something as non-propositional and non-verbal as ‘technique’. The insights of the neurosciences in, for example, the acquisition and transmission of drawing skills are not yet sufficiently advanced to be historically restrictive. However, only in the most recent years, the history of science and technology has turned to how-to instructions as given in recipes. This project proposes to undertake the experimental reconstruction of historical recipes to finally open the black box of the transmission of technique in the visual and decorative arts. Considering ‘technique’ as a textual, material and social practice, this project will write a long-term history of the theory and practice of the study of ‘technique’ in the visual and decorative arts between 1500 and 1950. The three central research questions here are: (1) what is technique in the visual and decorative arts, (2) how is technique transmitted and studied, and (3) who is considered expert in technique, and why? This project will make a breakthrough in our understanding of the transmission of technique in the arts by integrating methodologies typical for the humanities and historical disciplines with laboratory work. Also, by providing a history of technique in the arts, this project lays the historical foundations of the epistemologies of conservation, restoration and technical art history precisely at a moment of greatest urgency. The connection between the history of science and technology and the expertise in conservation, restoration and technical art history (in the Ateliergebouw in Amsterdam) this project envisions builds the intellectual infrastructure of a new field of interdisciplinary research, unique in Europe.

Mots-clés : history of knowledge,art and science,recipes
Projet ERC : LIGHTPORT (Horizon 2020, appel 2018, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Synthetic Chemistry and Materials
Entité participante : Leiden University — Pays : Pays-Bas — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499461.0 €

The transport of anions across the cell membrane, which is mediated by transport proteins, is essential to many important biological processes. Dysregulation of this transport has been associated to various diseases and therefore, chemists endeavour to develop artificial receptors that mimic the function of natural transporters. Despite much progress over the last decade, the current artificial systems are mostly static, while proteins are able to change their activity dynamically in response to stimuli in the environment. To integrate such stimuli-controlled behavior in synthetic systems is a key contemporary challenge. In view of this, the goal of the proposed research program is to develop anion receptors in which the binding properties can be effectively modulated by light and to apply these receptors as transmembrane carriers and pumps, in order to regulate passive transport (i.e. down a concentration gradient) and to induce active transport (i.e. against a concentration gradient). This interdisciplinary program is divided into three work packages: WP1 aims at the development of structurally rigid and visible-light-actuated photoswitches and their use as platforms for constructing anion receptors; WP2 deals with the development of mechanically interlocked structures as photoswitchable anionic hosts; WP3 is directed at utilizing these receptors for light-gated transport and light-driven pumping of anions across phospholipid bilayers, whereas also an alternative dual-responsive anion channel will be prepared. Eventually, it is expected that this work will open a new route toward light-based localized pharmacological treatment, e.g. via light-triggered cancer or bacterial cell death. Furthermore, active transport systems, that are able to build up and maintain concentration gradients across membranes, could provide a completely new view on how to convert and store light (solar) energy.

Mots-clés : anion binding,molecular switches,photochromism