Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : InteVol (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Computer Science and Informatics
Entité participante : Public University of Navarre — Pays : Espagne — Rôle : PI
Acronyme de l'entité : UPNA
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1495965.0 €

Displays in the shape of televisions, computer screens or phones are ever present in our education, work and entertainment. However, they do not take full advantage of our inner spatial abilities that we have to interact with the real world. True 3D displays can provide the same visual clues as the real world without forcing the users to wear devices. However, with State of the art (SoA) displays, the users cannot reach inside the display volume to directly interact with the virtual objects as they would do in real life. We envision a volumetric display capable of projecting true 3D virtual objects in mid-air that can be reached by the users to enable direct interaction, i.e. a reach-through volumetric display (RVD). This vision has been presented in multiple movies and books but there is no realization.  Three novel technologies will be developed and combined to create an RVD. 1) fast time-multiplexed acoustic fields will create virtual force fields that give shape to microfabricated light-scaterring particles. 2) Tomographic illumination will shine on the particles as a more scalable alternative to phase-based holographic. 3) Volumetric tracking of the particle distribution will control the previous technologies in a closed-loop manner. Applications will serve as benchmarks to test novel interaction techniques and develop a framework that fills in the knowledge gap for interactions with as yet nonexistent RVDs. The objectives of the project are: O1) find a set of technologies that enables the realization of RVDs, O2) create interaction techniques for RVDs and categorize them using a framework that will be applicable to future displays, our current frameworks for 3d-interactions may not be applicable to RVDs. O3) enhance an RVD with tactile sensations, spatial audio and study its effects on humans. The PI is uniquely qualified with experience in designing mid-air interactions and using levitated particles for displays.

Mots-clés : acoustic levitation,true 3d,direct inteaction,acoustic force fields,microfabrication,tomographic illumination,natural interaction
Projet ERC : MicroIMMUNE (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Life Science
Panel : Immunity, Infection and I mmunotherapy
Entité participante : Université d'Umeå — Pays : Suède — Rôle : PI
Acronyme de l'entité : UMU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1500000.0 €

Genome annotation, transcriptomic and proteomic pipelines have traditionally dismissed proteins encoded by short open reading frames (sORF) known as microproteins. This provides a pool of unexplored functional genes. Despite the increasing body of work in identifying the microproteome in different model organisms and cell lines, only a few have been functionally studied showing diverse regulatory roles in multiple cellular pathways.  In MicroIMMUNE, I present a 3-aim workflow combining computational and synthetic biology, protein and genetic engineering approaches designed to systematically uncover the microproteome atlas and investigate its interactome and functional role in innate immune cells.  We aim to: 1) Identify microproteins expressed in innate immune cells under resting and stimulating conditions, using state-of-the-art computational and experimental approaches to study the microproteome. 2) Develop genetic code expansion technologies in innate immune cells to incorporate non-canonical amino acids to study the localization and binding partners of microproteins. 3) Elucidate the function of microproteins in innate immune cells by combining genetic engineering with an array of high-throughput functional assays and automated analysis pipelines. Our research output will address key questions such as: What is the microproteome atlas in innate immune cells and how does it vary upon activation? Where are the microproteins localised and in which protein-protein interactions are they involved? What functions do different microproteins play in innate immune cells? Understanding the role of microproteins in innate immune cells can revolutionise our understanding of the immune response at a fundamental level and open new avenues for therapeutic interventions in which new antimicrobial peptides or druggable targets could be discovered.
Projet ERC : MUST (Horizon Europe, appel 2022, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Materials Engineering
Entité participante : Université Aalto — Pays : Finlande — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499978.0 €

Despite more than a century of interest in the effects of energetic particles in matter, quantitative predictions of the radiation damage remain elusive in many cases. The goal of this project is to transform the study of radiation-induced damage in semiconductors from an empirical approach to one of fundamental physics, to obtain reliable predictions of radiation damage crucial for practical applications. Particle irradiation effects are of great importance, since they can modify the physical and mechanical properties of materials, the outcome of which is often detrimental to the materials employed in high radiation environments. Conversely, ion irradiation also has the potential to improve material performance, and ion beam modification of materials is used widely in semiconductor technology. In this project, I will elucidate the fundamental quantum effects under irradiation in semiconductors, and their impact on the atomic dynamics, through a multi-scale modelling scheme employing a combination of ab initio calculations and large scale atomistic simulations. The high gain from the project will be quantitative high-fidelity predictions of radiation effects in semiconductors, to enable the optimal design of components for power devices, and the development of next generation electronics for demanding environments.  I will develop a genuinely predictive modelling scheme, using a combination of state-of-the-art first principles calculations, machine learning methods for modelling atomic interactions, and molecular dynamics simulations in multi-million atom systems, together with electron microscopy simulations and ion range calculations to obtain quantitative predictions of experimentally measurable radiation effects for different irradiating particles and energies. This methodology will form a truly bottom-up approach to the study of radiation damage in technologically relevant semiconductor materials.

Mots-clés : radiation damage,defects,molecular dynamics,density functional theory
Projet ERC : ModelMisspec (Horizon Europe, appel 2024, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Individuals, Markets and Organisations
Entité participante : Université Aalto — Pays : Finlande — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1487820.0 €

Differences in how individuals interpret the same information have proven to play an important role in societal decision making. Yet, most economic models assume individuals not only interpret information correctly but fundamentally agree on how information should be interpreted. In ModelMisspec, I will develop a unified framework that links two approaches to modeling information processing biases. I plan to (i) develop a unified framework to model information processing biases, (ii) develop tools, both theoretical and empirical, that can be applied to the analysis of problems this framework, and (iii) bring this framework to bear on applied models to study to the role of biases in price dynamics, learning, reputation and other applications.  The proposed project has theoretical, empirical and applied components. In the theory part, I will develop a unified framework that bridges two common approaches to modeling biases. This approach provides a transparent and general framework for modeling information processing biases. I'll then use this framework to explore the implications of information processing biases for decision making. In the second part, I study misspecification empirically. In the first empirical component, I will experimentally elicit a key part of this framework, the forecast. This object is an key piece of decision making, that has gone unstudied. I also will study misspecification in the field, through a survey of Finnish drivers' beliefs about the penalty schedule for speeding. This section will focus on both developing tools for studying misspecification empirically, and its implications for decision making.  Finally, I plan to explore the economic applications of this framework, including timing games, social learning, reputation, markets, etc.
Projet ERC : CompLex (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Université Aalto — Pays : Finlande — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499240.0 €

Combating climate change, safeguarding democracy, regulating Artificial Intelligence: Societies worldwide are facing a deluge of urgent and fundamental challenges. Legal systems play an essential role in addressing these challenges, but many of them are struggling to respond effectively.  Improving the capacity of our legal systems to handle current and future challenges requires novel tools for analyzing and monitoring legal systems. Complexity science provides a framework for developing these tools, permitting the principled and systematic study of law as a complex system—an evolving network of diverse agents that interact via adaptive, rule-based behaviors and make interdependent choices. CompLex will work toward a computational theory of legal systems as complex systems. Drawing on concepts and techniques from computer science and network science, the project will contribute the main building blocks of such a theory: multilayer maps to capture the relationships between the components of legal systems, meaningful measures characterizing their interdependencies and interactions, and mechanistic models that explain our observations and guide us in improving our systems. The methods resulting from CompLex will allow scientists, policymakers, and the general public to better understand and mitigate critical challenges faced by legal systems today—such as ensuring their robustness to attacks, their resilience to failures, and their adaptation to changing environments.  CompLex builds on my pioneering work in developing the methodological toolkit for studying legal systems as complex systems, and it is enabled by my unique background, which combines expertise in law, computer science, and network science. By devising a computational framework for studying legal systems as complex systems and demonstrating its practical utility, CompLex will introduce a novel paradigm in our treatment of legal systems, catalyzing a computational complexity turn.

Mots-clés : legal networks,legal data science,computational legal studies,complex networks,network science,empirical legal studies,law and artificial intelligence
Projet ERC : STICKY (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed Matter Physics
Entité participante : Université Aalto — Pays : Finlande — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1499663.0 €

Soft wet adhesion is a physical phenomenon exploited by organisms that live in wet environments to allow them to adhere to surfaces despite charge barriers that typically hinder adhesion. The physics underpinning soft wet adhesion has been studied for over a century. The interplay between charge and adhesion dynamics in soft adhesion is strongly complicated by non-linear and time-dependent effects for different compression rates and environmental conditions and remains poorly understood due to the lack of simultaneous charge and force-based experiments on pairwise interactions in dynamic conditions. Understanding charge-adhesion interplay is important for novel biomedical and engineering applications. Here, I will develop an Electro-Adhesion Microscope to probe real-time interactions between soft wet adhesion and charge at piconewton and femtocoulomb resolutions. Using a hydrogel soft probe to mimic tissue and conductive hydrogel as soft adhesive I will determine how charges vary with compression rates and stiffnesses for anionic and cationic adhesives and soft probe, and how these charge changes influence adhesion in water and complex fluids. By adopting soft probe to wet probe, I will also explore these interactions in the presence of a thin liquid film in air. Together this will resolve several major questions on charge-adhesion interplay, with the grand goal of discovering new insights into how and why charges influence soft wet adhesion dynamics. These experiments will pave the way for new research in soft matter adhesion dynamics, providing critical data on force, charge, interface deformations, and fluid dynamics for theorists and engineers in biomedical applications. The outcomes of this project will enable the creation applications such as regenerative medicine (designing scaffolds for tissue regeneration), drug delivery (creating surfaces to enhance or inhibit cellular uptake of therapeutics), and biosensing (developing susceptible detection systems).

Mots-clés : soft matter physics,soft matter adhesion,soft interfaces,charging,wetting
Projet ERC : MaxFUSE LNPS (Horizon Europe, appel 2023, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Condensed Matter Physics
Entité participante : KTH Institut royal de technologie — Pays : Suède — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1844248.0 €

There is a strong need for personalised genetic medicines for the treatment of advanced breast cancer. LNP-mRNA nanomedicines have already been proven as safe and cost effective in the SARS-CoV-2 vaccines. However, cancer treatments often require (i) repeat dosing (ii) controlled immune response (iii) adaptability to combat drug resistance. There are several LNP-RNA clinical cancer trials ongoing, many of which have reported challenges with toxicity, performance and specificity (off target effects). For an LNP-RNA cancer therapeutic to function, they need to localise in the correct organ, enter the cancer cells and escape the cellular (endosomal) processing pathway to release their RNA cargo. In current LNP-RNA formulations only a small fraction (<10 %) of LNPs successfully escape the endosome. However, these ‘null’ LNPs can still contribute to toxicity which places huge restrictions on their clinical application and performance. The aim of this proposal is to provide mechanistic insight into the endosomal escape of LNPs and use nanoscale engineering to target the endosome and improve LNP endosomal escape. This is particularly relevant in breast cancer as the majority of LNP systems are optimised for liver applications and designed to undergo fusion under ‘healthy’ endosomal conditions. In breast cancer, the composition (lipid, protein) and environment (pH) of the endosome differ significantly between healthy and cancer cells. Objectives: - Use omics approaches to quantify key differences in the endosome in healthy and breast cancer sub type cells and develop breast cancer sub type endosome models - Design LNPs with enhanced fusion to endosomes using (i) lipid composition (ii) protein – protein / lipid interactions (iii) pH mediated fusion - Validate novel LNPs with increased endosomal fusion and lower toxicity for breast cancer treatment

Mots-clés : lipid nanoparticles,membrane fusion,x rays,neutrons,microscopy
Projet ERC : PARAMLP (Horizon Europe, appel 2025, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Computer Science and Informatics
Entité participante : Université du Danemark du Sud — Pays : Danemark — Rôle : PI
Acronyme de l'entité : SDU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1498648.0 €

Polyhedral techniques allow the powerhouse of linear programming to be used for the discrete problems in combinatorial optimization. Their impact on commercial solvers, the theory of classical algorithms, as well as approximation algorithms, is well established. Nevertheless, these techniques play only a marginal role in mainstream research on parameterized algorithms. Recent advances, many of which are due to the PI, are showing potential for a revolutionary synergy between parameterized algorithms and polyhedral techniques. This project aims to unlock the full power of this synergy and use it to address several pressing open questions in combinatorial optimization. The work plan consists of three complementary directions:  I. Exploring new frontiers for polyhedral techniques in parameterized algorithms, in particular, the novel usage of proximity bounds to obtain FPT algorithms. We will specifically investigate the open question of whether bin packing in the number of item sizes is in FPT.  II. Closing notorious loose ends in existing research lines, in particular, the lack of polyhedral understanding of algebraic methods in matroid problems.  III. Embracing parameterization to strengthen polyhedral techniques in approximation algorithms. Specifically, we will investigate an innovative technique crucial for understanding the approximability of scheduling on unrelated parallel machines, max-min fair allocation, and directed Steiner tree.  The topics of the project are relevant for a broad spectrum of researchers from both parameterized algorithms and approximation algorithms and have the potential to bring these fields much closer together.
Projet ERC : ELECTROCOFS (Horizon Europe, appel 2021, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Materials Engineering
Entité participante : Université de Saint-Jacques-de-Compostelle — Pays : Espagne — Rôle : PI
Acronyme de l'entité : USC
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1258382.75 €

A major breakthrough in chemistry and materials science has been the development of Lithium-Ion Batteries (LIBs), which show great potential for storing energy from renewable sources and as the power sources for electric cars. However, commercially available LIBs are based on transition metal oxide cathodes, presenting limited energy density and raising relevant environmental concerns. Organic materials have received much attention as alternative electrodes because of their high theoretical capacity, resources availability and sustainability. In particular, Covalent Organic Frameworks (COFs) have emerged in the past few years as promising organic electrode materials due to their high stability, high ionic conductivity and outstanding chemical and structural versatility. Low electrical conductivity remains the main bottleneck for real applications of COFs as electrode materials, usually addressed by adding in large amounts of conductive carbon additives that decrease the energy density of the battery. The overarching objective of this project is to design and synthesize new conductive redox-active COFs as cathode materials to enhance LIBs electrochemical performance. The specific goals are: a) To design a new family of stable redox-active COFs built from unexplored building blocks to achieve an optimal balance between capacity, electrical conductivity and porosity. b) To investigate the role of the linkages, building blocks, doping, pressure, anisotropy and morphology on the electrical conductivity, unravelling the fundamental mechanisms of charge transport in COFs. c) To manufacture and test lithium batteries using conductive COFs cathode materials, assessing the influence of the processing techniques on the electrochemical performance.

Mots-clés : covalent organic frameworks electrical conductivity energy storage lithium ion batteries
Projet ERC : CONFRONT (Horizon Europe, appel 2023, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Université de Bergen — Pays : Norvège — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1544896.0 €

Between Indigenous self-determination and settler colonization lie contested frontiers, subject to metapolitics – i.e., to competition over the framing of polities. In the past, settlers, using force, domesticated frontiers. Recent decades have seen an Indigenous resurgence, rekindling metapolitics, particularly on settler-state peripheries. These contests are increasingly waged by weaponizing “constitutive principles”: Is the demos universal or divisible? Should individual or collective rights prevail? Should democracy or self-determination decide? Resolving such contests is difficult. Yet the metapolitics of today’s frontiers have escaped political-science attention.  CONFRONT aims to develop a theory of frontier metapolitics. It will study contests over constitutive principles in, and how such contests shape and are shaped by, settler-state peripheries. It will gather and test data from settler federal territories and related peripheries to pursue four research objectives: conceptualizing metapolitics to render it cognizable, compiling the first dataset of frontier constitutive metapolitical contests, analysing such contests and their interaction with the constitution of peripheries, and normatively theorizing how such contests should be approached/resolved.  CONFRONT will combine comparative politics, comparative constitutional law, and normative political theory to identify and open a salient new research field. Led by a pioneer of settler-metapolitical studies with a unique pre-academic background in peripheral areas, this project will make modern frontier metapolitical contests visible, comprehensible, and more soluble. If successful, it will place peripheries central to studies of metapolitics, inspiring and preparing scientists, decisionmakers, civil-society actors, and even colonized peoples to grapple with the rising metapolitical instability of peripheries and of the “late Westphalian” world at large.

Mots-clés : settler colonialism,decolonization,indigenous rights,metapolitics,frontiers,peripheries,state building,westphalianism,comparative constitutionalism,comparative politics,normative political theory