Data-Gouv-ML/pcri-erc-participations-et-projets-laureats huggingface dataset:
Projet ERC : CoMoFun (Horizon 2020, appel 2020, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Fundamental constituents of matter
Entité participante : Imperial College London — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1561158.74 €

Laser cooling of atomic gases in a magneto-optical trap (MOT) has revolutionized modern physics. A MOT uses precisely tuned lasers and a magnetic field to cool atoms and trap them. It has enabled the invention of precise instruments, such as atomic clocks, magnetometers, gravimeters and accelerometers. It has also enabled new fundamental research with unprecedented precision and the study of matter dominated by quantum effects. However, there is still potential to push the boundaries of science and technology: using ultracold molecules. Project CoMoFun aims to do just this, creating a high-density ultracold gas of polar molecules by laser cooling to build a new platform for fundamental research. A high-density ultracold gas of polar molecules has a wide range of new applications. It can be used to study a dipolar quantum gas, to test fundamental physics and to store and process quantum information efficiently. An array of polar molecules, all interacting with each other via controllable and strong interactions, can serve as a universal simulator for more complex quantum systems that cannot be modeled by a computer. Simulating such strongly-interacting many-body systems from the bottom-up will aid the understanding of fascinating phenomena such as high-temperature superconductivity and exotic forms of magnetism. Recently, it has become possible to make a MOT of molecules. However, the density of the molecules is far too low for most applications. CoMoFun will increase the density by five orders of magnitude by laser-cooling stable and deeply-bound aluminum monofluoride molecules. The high density provides an excellent starting point to investigate evaporative cooling to quantum degeneracy. The molecules can then be arranged in a regular array by loading them into a trap formed by interfering laser beams. This instrument can then be used for precision measurements and applications in quantum information and simulation, to realize the full potential of molecular MOT.

Mots-clés : ultracold molecules,quantum simulation,laser cooling,precision measurements
Projet ERC : BeeDanceGap (Horizon 2020, appel 2014, Starting grants)
Domaine scientifique : Life Science
Panel : Environmental Biology, Ecology and Evolution
Entité participante : University of Bristol — Pays : Royaume-Uni — Rôle : Partner
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 0.0 €

Learning from others is fundamental to ecological success across the animal kingdom, but a key theme to emerge from recent research is that individuals respond differently to social information. Understanding this diversity is an imposing challenge, because it is hard to replicate the overwhelming complexity of free-living groups within controlled laboratory conditions. Yet here I propose that one of the most complex social models that we know of— the sophisticated eusocial societies of honeybees— offer unrivaled and yet unrecognized potential to study social information flow through a natural group. The honeybee “dance language” is one of the most celebrated communication systems in the animal world, and central to a powerful information network that drives our most high-profile pollinator to food, but bee colonies are uniquely tractable for two reasons. Firstly, next-generation transcriptomics could allow us to delve deep into this complexity at the molecular level, on a scale that is simply not available in vertebrate social systems. I propose to track information flow through a natural group using brain gene expression profiles, to understand how dances elicit learning in the bee brain. Secondly, although bee foraging ranges are vast and diverse, social learning takes place in one centralized location (the hive). The social sciences now offer powerful new tools to analyze social networks, and I will use a cutting-edge network-based modelling approach to understand how the importance of social learning mechanisms shifts with ecology. In the face of global pollinator decline, understanding the contribution of foraging drivers to colony success has never been more pressing, but the importance of the dance language reaches far beyond food security concerns. This research integrates proximate and ultimate perspectives to produce a comprehensive, multi-disciplinary program; a high-risk, high-gain journey into new territory for understanding animal communication.

Mots-clés : social learning,communication,pollinator behaviour
Projet ERC : CIRCODE (Horizon 2020, appel 2014, Starting grants)
Domaine scientifique : Life Science
Panel : Immunity, Infection and Immunotherapy
Entité participante : Ludwig-Maximilians-Universität München — Pays : Allemagne — Rôle : PI
Acronyme de l'entité : LMU
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1497688.0 €

Leukocytes are the key components of the immune system that fight infections and provide tissue repair, yet their migration patterns throughout the body over the course of a day are completely unknown. Circadian, ~24 hour rhythms are emerging as important novel regulators of immune cell migration and function, which impacts inflammatory diseases such as myocardial infarction and sepsis. Altering leukocyte tissue infiltration and activation at the proper times provides an option for therapy that would maximize the clinical impact of drugs and vaccinations and minimize side effects. We aim to create a four-dimensional map of leukocyte migration to organs in time and space and investigate with epigenetics techniques the molecular mechanisms that regulate cell-type specific rhythms. We will functionally define the daily oscillating molecular signature(s) of leukocytes and endothelial cells with novel proteomics approaches and thus identify a circadian traffic code that dictates the rhythmic migration of leukocyte subsets to specific organs under steady-state and inflammatory conditions with pharmacological and genetic tools. We will assess the impact of lineage-specific arrhythmicities on immune homeostasis and leukocyte trafficking using an innovative combination of novel genetic tools. Based on these data we will create a model predicting circadian leukocyte migration to tissues. The project combines the disciplines of immunology and chronobiology by obtaining unprecedented information in time and space of circadian leukocyte trafficking and investigating how immune-cell specific oscillations are generated at the molecular level, which is of broad impact for both fields. Our extensive experience in the rhythmic control of the immune system makes us well poised to characterize the molecular components that orchestrate circadian leukocyte distribution across the body.

Mots-clés : circadian immunology,leukocyte migration,endothelial cell adhesion molecule,leukocyte adhesion molecule
Projet ERC : NICCA (Horizon 2020, appel 2020, Consolidator grants)
Domaine scientifique : Life Science
Panel : Prevention, Diagnosis and Treatment of Human Diseases
Entité participante : Amsterdam University Medical Centers — Pays : Pays-Bas — Rôle : PI
Type d'entité : Recherche
Financement ERC de l'entité : 1999690.0 €

Life expectancy in the European Union is rising and the prevalence of age-induced cardiovascular disease increases concomitantly. The main clinical presentation of age-induced cardiovascular disease is heart failure with preserved ejection fraction (HFpEF). HFpEF is a complex disease involving different cell types and mechanisms that contribute to impaired relaxation of cardiomyocytes. Currently there is no appropriate treatment for HFpEF. This proposal aims to better understand the molecular mechanisms behind intercellular communication and ageing that lead to HFpEF. Long non-coding RNAs (lncRNAs) are emerging as novel key regulators of cellular functions and we hypothesize that lncRNAs contribute to ageing-induced cardiac dysfunction, including HFpEF. Preliminary experiments show that several long non-coding RNAs (lncRNAs) are differentially regulated during cardiac ageing, including the cardiomyocyte-enriched lncRNA Sarrah that is essential for cardiomyocyte survival. We propose to extensively characterize the role of Sarrah in HFpEF and to identify other lncRNAs that are involved in cardiac ageing. Importantly, we will focus those lncRNAs that are also affected in a cohort of human HFpEF patients. Furthermore, since disturbed intercellular communication is a hallmark of both ageing and HFpEF, we will identify lncRNAs that regulate endothelial cell-cardiomyocyte crosstalk. We will use state-of-the-art in vitro and in vivo models to assess cardiac ageing and function upon gain-of-function and loss-of-function of lncRNAs in a cell-type specific manner. Understanding the role that Sarrah and other lncRNAs play in cardiac ageing and HFpEF will highlight novel potential therapeutic targets to attenuate age-induced cardiac dysfunction and will increase our knowledge of the underlying mechanisms controlling intercellular communication and cardiac function.
Projet ERC : REPLY (Horizon 2020, appel 2020, Consolidator grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Products and processes engineering
Entité participante : Italian Institute of Technology — Pays : Italie — Rôle : PI
Type d'entité : Recherche
Financement ERC de l'entité : 1986250.0 €

Life on Earth relies to a large extent on light-matter interactions. Photosynthesis is indeed a brilliant example of chemistry driven by light, which, as almost any naturally occurring interaction is optimized for the preservation of life. With the study of photocatalysis mankind targets to copy such natural processes, adapting them to the production of energy. In this context, REPLY represents an effective solution to impart control and acceleration on photoreactions for solar-to-fuel conversion via water splitting. To improve device efficiencies and to create new paradigms in semiconductor-based photocatalytic technology, here we propose to strengthen the coupling between light and photocatalysts, by exploiting the outstanding capabilities of plasmonic architectures in manipulating the electromagnetic radiation at the nanoscale. Precisely, a new energy landscape inside the semiconductor photocatalyst can be created via light/matter hybridization in the strong-coupling regime. This will ensure the effective control of the junction barrier height at the semiconductor/co-catalyst interface and a paradigmatic redefinition of the energetics and charge-transfer characteristics at solid/liquid heterojunctions. The proposed approach is readily converted to cost-effective semiconductor/co-catalyst ensembles in order to achieve photocatalytic activities comparable or even superior to the ones of “golden benchmarking systems”, typically based on toxic and/or unaffordable noble metals. The project identifies three objectives to reach the final goal of fabricating photo(electro)catalytic devices based on strong coupling regime: I) the realization of a new class of adaptive heterojunctions via light-matter hybridization; II) the understanding of the photophysical mechanisms that regulate the system architecture; III) the fabrication and characterization of a novel efficient photo(electro)catalyst prototype for solar-to-hydrogen conversion.

Mots-clés : fabrication of nanocomposites for solar to hydrogen photo conversion,plasmonic cavities,semiconductor junctions,light matter hybrid states
Projet ERC : TERRA (Horizon 2020, appel 2014, Starting grants)
Domaine scientifique : Physical Sciences and Engineering
Panel : Earth system science
Entité participante : University of Birmingham — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1495063.0 €

Life on land today is spectacularly diverse, representing 75–95% of all species on Earth. However, it remains unclear how this extraordinary diversity has been acquired across deep geological time. This research project will address this major knowledge gap by reassessing the dominant paradigm of terrestrial diversification, an exponential increase in diversity over the last 375 million years, using the rich and well-studied fossil record of tetrapods (four-limbed vertebrates) as an exemplar group. Previous analyses of tetrapod diversification have been based on an outdated and problematic dataset that is likely to artificially inflate apparent diversity towards the present day. A major new dataset will be assembled, detailing the spatial and temporal distribution of terrestrial tetrapods across their entire fossil record in unprecedented detail. These data will be analysed using the latest approaches to sampling-standardisation in order to generate completely novel, rigorous curves of diversification through time. These will be compared within a cutting-edge statistical framework to alternate diversification models, as well as to changes in rock record sampling, global environments (e.g. sea level and atmospheric composition) and marine diversity. These comparisons will allow us to address the following key questions: (i) Does terrestrial diversification follow an exponential pattern over the last 375 million years? (ii) Is the terrestrial fossil record as complete as the marine fossil record? (iii) Are long-term patterns of terrestrial diversification driven by physical changes in the Earth system such as climate change? (iv) Did marine and terrestrial biodiversity follow similar trajectories across geological time? (v) How severely did mass extinction events impact upon terrestrial tetrapod diversification? Our work will establish a new, rigorous paradigm for the long-term pattern of terrestrial diversification, and test and identify its drivers.

Mots-clés : biodiversity,tetrapoda,fossil record,terrestrial,environmental change
Projet ERC : BIOSPACE (Horizon 2020, appel 2018, Advanced grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Institutions, Governance and Legal Systems
Entité participante : Wageningen University & Research — Pays : Pays-Bas — Rôle : Partner
Acronyme de l'entité : WUR
Type d'entité : Recherche
Financement ERC de l'entité : 217638.75 €

Life, with all its diversity, is in crisis. As humans increasingly encroach on biologically complex semi- natural landscapes, no organism, place or ecological function remains unaffected. While all 196 parties (195 countries plus the European Union) to the UN Convention on Biodiversity (CBD) have agreed to monitor the state of biodiversity, the currently available methods to do so leave much to be desired. Traditional monitoring involves the field observation of species by trained specialists, aided by skilled volunteers, whose expertise is restricted to specific biotic groupings. In a process that is both time consuming and inconsistent across time and space, botanists identify and record the presence of plant species and ornithologists the bird biota, resulting in 'unpopular' biotic groups such as fungi, bacteria and insects being under-observed or escaping identification altogether. In this project, a fundamentally different approach to terrestrial biodiversity monitoring couples next generation satellite remote sensing with environmental DNA (eDNA) profiling, complemented where available by legacy human-observed datasets. Satellite remote sensing is able to survey the environment as a single, continuous, fine-resolution map, while eDNA profiling can rapidly quantify much greater taxonomical and functional breadth and depth than human field observation. This project combines, for the first time, these two powerful, cutting-edge techniques for monitoring biodiversity at the global level in a consistent manner. Following from this, another key innovation will be the deepening of our scientific understanding of how biodiversity is impacted by anthropogenic pressure as well as by natural environmental gradients. In concert, these scientific developments will enable the accurate and fine grain monitoring of biodiversity from space – a ground-breaking contribution to the quest to meet the UN Sustainable Development Goals and CBD Aichi targets.
Projet ERC : SFICAM (Horizon 2020, appel 2017, Proof of concept grants)
Entité participante : Weizmann Institute of Science — Pays : Israël — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 150000.0 €

Light microscopy is critical to many fields, from biology and medicine to technology development and industry. One important breakthrough that enabled the development of super-resolution microscopy was the development of enhanced cameras capable of recording low light-level images with single-photon sensitivity. However such gain in spatial resolution is compromised by low temporal resolution, since these cameras work at video rate or somewhat faster, while many applications require to characterize dynamics which could be a million times faster. We propose here a proof of concept demonstration of a technique that enhances the resolution of optical microscopy in both space and time by significantly enhancing camera frame rates while still retaining single-photon sensitivity. Our approach is to form a single-photon sensitive camera using an array of fibres to guide light into single-photon detectors. In this proof-of-concept of a Single-Photon Fibre-optics Camera (SFICAM), we shall demonstrate a device that could resolve light emitters spatially with nanometric resolution and temporally with nsec precision. We argue that even with a limited number of elements, and therefore with a small frame size, such cameras could be effective, by combining them with scanning laser microscopy techniques. In the course of this POC project we shall expand the small SFICAM already constructed during the project QUAMI using either individual single photon detectors or monolithic arrays of detectors, and demonstrate its utility and advantage in several microscope modalities. We shall also pursue IP protection of our device and proactively search for industrial partners that will advance it to market.

Mots-clés : microscopy,single photon camera,super resolution,particle tracking
Projet ERC : R2-TENSION (Horizon 2020, appel 2020, Synergy grants)
Entité participante : University of Geneva — Pays : Suisse — Rôle : PI
Acronyme de l'entité : UNIGE
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 2449315.0 €

Lipid membranes compartmentalize and protect cells from the environment, and selectively permit transport. This functionality derives from unique membrane properties: 5 nm thick, yet fluid, deformable, resistant to stress and chemically complex. The physicochemical properties of membranes are expected to have a major impact on cell life, but the tools to measure the relevant multiscale and dynamic parameters in-vitro and, more importantly, in-vivo membranes are lacking. An essential property of membranes, their hydration and charge state, both needed for membrane integrity and playing a vital role in cell survival is not understood beyond the level of continuum theory. To enable quantitative physics, and physical chemistry for biology Roux and Roke, R^2, will join their expertise on molecular biology & biophysics and physics & interfacial chemistry & optics to create tools to measure membrane water and ion fluxes, and image 3D fields of electrostatic free energy, membrane tension and curvature. We will understand how molecular factors, such as the influence of the aqueous phase and interfacial electrostatics, are coupled to tension and curvature under dynamic conditions such as osmosis in artificial and cellular membranes. Obtaining the first temporally resolved, 3D maps of hydration, free energy, tension and curvature at the nanoscale in migrating cells and cells experiencing osmotic shocks we will quantify membrane physical parameters in two processes essential for cell survival, for which currently no data is available: Osmotic shock response and cell migration. Osmotic shock response plays an important role in infections, kidney and intestine function. Cell migration is essential to many cell processes, for example the spreading of cancer, wound repair and the immunological response, as well as food search in unicellular organisms.

Mots-clés : water,nonlinear optics,membranes,free energy,osmosis,osmotic shock response,cell migration
Projet ERC : GlobalLIT (Horizon 2020, appel 2017, Starting grants)
Domaine scientifique : Social Sciences and Humanities
Panel : Cultures and cultural production
Entité participante : University of Birmingham — Pays : Royaume-Uni — Rôle : PI
Type d'entité : Enseignement supérieur ou secondaire
Financement ERC de l'entité : 1434742.0 €

Literary theory is often regarded as a twentieth century invention, with no precedents prior to modernity. This relegates older discourses on literature to the status of source material, pertaining to literature’s past, rather than as springboards for literature’s future. While the self-understanding of literary theory’s modernity helped to bring about the discipline’s birth, and hence was innovative in its own time, at present it accounts for many gaps and limits within its current structure, whereby European aesthetic categories remain normative and lesser-known geographies are marginalized within synthetic accounts of literary form. Even when the literatures studied are non-European, the literary theory used to understand these texts often circulates within a restricted set of modern European traditions. A more pluralistic approach to literary knowledge that takes account of the radically different temporalities in the genesis of literary form across different literary traditions, and which explores the different meanings of literature across varying historical and cultural contexts, will reinvigorate the discipline of literary studies with new understandings of the capacity of critique, new views of the role of aesthetic judgment and its ontological foundations, and new ways of imagining the status of literature—poetry in particular—in the public sphere. Through four case studies of Arabic, Persian, Turkic, and Georgian literary theory in the Islamic world (especially the Caucasus), we will produce co-authored articles, individual monographs, and a cumulative anthology of key contributions to literary theory from the Islamic world. Moving beyond the parameters of modernity itself, GlobalLIT seeks to invigorate the discipline of literary studies with new answers to ancient questions. While some of our texts have been studied before, most have not been the subject of sustained scholarly research, and have never before been placed into systematic comparison.

Mots-clés : world literature,literary theory,poetics,rhetoric,translation,transnational,caucasus,islam,middle east