Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ZeroNegCon (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The objective of this fellowship is to train Dr Yunjian Li through the research project titled “Development of Zero-Clinker, Negative-CO2 Concrete from the Atomic Scale (ZeroNegCon)”. This project aims to develop zero-clinker, negative-CO2 concrete for sustainable construction and environmental protection by utilising theoretical design at the atomic scale, nanotechnology, electrolysis and carbon mineralisation technology. In this project, the research will uncover the nanoscale mechanisms of C-S-H formation and carbonation, and CaCO3 crystalline phase transformation, providing theoretical guidance for C-S-H preparation and carbonation, and CaCO3 polymorph control. A zero-clinker cementitious material system will be established with in situ synthesis of C-S-H using ions extracted from natural minerals or industrial byproducts through the electrolysis method. Negative CO2 emission in concrete production will be achieved by applying carbon mineralisation technology to the zero-clinker cementitious materials. The project will also focus on the industry application of zero-clinker, negative-CO2 concrete and evaluate its overall performance. This project seeks to revolutionise the field of construction materials by providing a pathway toward significantly reducing carbon emissions in cementitious binders and concrete. By integrating advanced atomistic modelling techniques, nanoengineering and materials science, this research has the potential to set new standards in sustainable construction, influencing future innovations and policy-making in environmental protection and green building technologies. The success of this project will not only advance scientific understanding but also have a far-reaching impact on global efforts to mitigate climate change.

Mots clés : zero clinker cement, negative co2 concrete, atomistic simulation, electrolysis for cement production, carbon mineralisation

Participants :
- Université du Pays basque (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University College de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université technique de Riga (Lettonie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Brunel University London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
- Wienerberger france (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet CliAgroSec (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : TERMINATED

The European Union's goal of achieving climate neutrality by 2050 is crucial for transitioning to a low-carbon economy. However, ambitious reductions in greenhouse gas emissions may lead to unintended consequences, notably from current EU policies. On one hand, increasing food production for Zero Hunger (SDG 2) can escalate greenhouse gas emissions, responsible for about 34% of total anthropogenic emissions. Predictably, direct carbon emissions from agriculture will rise in the coming decade. Yet, mitigating these emissions, especially in the short term, may reduce production and raise food prices, potentially limiting access, especially in food-insecure regions. This could lead to increased poverty and stunting. Balancing emissions reduction with agricultural productivity and global food security is a critical challenge. To avoid unintended negative consequences and optimize climate protection policy benefits, interactions between different objectives must be considered in policy formulation. The CliAgroSec project aims to create a framework exploring synergies between agricultural productivity, food security, and climate protection objectives, while acknowledging trade-offs in multi-objective policy development. This involves crafting comprehensive "sustainable policies" encompassing environmental, economic, and social dimensions. The project has three specific objectives: Elaborate on potential synergies and trade-offs between climate protection policies, agricultural productivity, and food security. Propose a theoretical framework to identify negative externalities of climate protection policies within global climate agreements. Develop a comprehensive integrated empirical model, combining a global Computable General Equilibrium (CGE) model with an agri-environmental model. Assess the effectiveness of climate protection policies across countries and scales, capturing the intricate dynamics of agricultural systems and their environmental implications.

Mots clés : agricultural economics, climate change, climate policy, agro food policy, synergies, trade offs, general equilibrium modelling, agricultural productivity, food security

Participants :
- Université de Parme (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- Johann Heinrich von Thünen Institute Federal Research Institute for Rural Areas, Forestry and Fisheries (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet PREPARE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Regular physical activity is known to be beneficial for health, can prevent cardiovascular disease and reduce overall mortality. However, high intensity exercise can promote the development of arrhythmias and cause sudden cardiac death. Recently the Prof.Peter Schwartz’s group discovered the phenomenon of exercise-induced Long QT Syndrome (exiLQTS). Affected athletes develop significant QT interval prolongation and repolarization abnormalities on the electrocardiogram during training periods and normalisation occurs during detraining. Clinically, these athletes resemble patients with congenital LQTS, who are known to be severely at risk for life-threatening arrhythmias, but no pathogenic genetic variants in main genes responsible for LQTS were found. Data on how exercise could trigger pathogenic QT prolongation and arrhythmias is limited and thus the possibilities to evaluate potential risks and prevent sudden cardiac death in these young athletes are currently absent. This project will use a precision medicine approach to reveal molecular culprits of exiLQTS by: i) demonstrating that the disease could be recapitulated in vitro using athlete-specific induced pluripotent stem cell-derived cardiomyocytes models; ii) creating a statistical model integrating genetic, electrophysiological, and molecular data; iii) discovering major factors responsible for exiLQTS development and identifying molecular targets for risk stratification and therapy. Results of the study will shed the light on mysterious exercise-related QT prolongation and will contribute to better risk assessment and clinical management of arrhythmias in young athletes.

Mots clés : exercise, athlete, long qt syndrome, human induced pluripotent stem cells, ipscs, cardiomyocytes, cardiac arrhythmias, disease modeling, precision medicine, electrophysiology, molecular biology

Participants :
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Coordinator, beneficiary, Recherche, subvention : 188590.08 €
Projet MORPHOMICS-IPF (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The aim of this research project is to understand the dynamics within the progressing fibrotic lung to identify biologically meaningly interactions which could serve as treatable targets in the future. Therefore, we will use a spatially resolved study set-up involving multiple layers of cutting-edge -omics technologies wherein the inherent variability will be used as a surrogate for disease progression by in-depth quantification of disease extent using microCT and different staining techniques.

Mots clés : pulmonary fibrosis,  omics, systems biology

Participants :
- Helmholtz Zentrum München (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet MetaboKID (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Chronic kidney disease (CKD) affects 10% of the population and fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of CKD. Myofibroblasts are the key ECM producing cells and are activated by cross-talk with injured proximal tubule anChronic kidney disease (CKD) affects 10% of the population and fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of CKD. Myofibroblasts are the key ECM producing cells and are activated by cross-talk with injured proximal tubule and immune cells. Although a derangement in fatty acid oxidation (FAO) of tubular epithelium is crucial in the pathophysiology of CKD, the metabolic rewiring of kidney myofibroblasts remains elusive. Our preliminary observations suggest that cell type-specific metabolic shifts could define new cellular subpopulations with a differential role in the fibrogenic response. To understand this, the following objectives have been defined: 1. To decipher the role of FAO in myofibroblasts during kidney fibrosis; 2.To dissect metabolic changes as important drivers of kidney fibrosis and CKD; 3. To validate key metabolic pathways in complex ex vivo models of kidney fibrosis. To address these aims, I will map the genetic and metabolic spatio-temporal features of kidney fibrosis by a combination of cutting-edge multi-omics technologies at large scale (Spatial single cell ATAC sequencing for transcriptomics and Space M for metabolomics). This will be complemented by advanced computational analyses and modeling, using CKD human biopsies and mouse renal samples from available genetic models for myofibroblast tracing and FAO enhancement. Innovative in vitro systems (cell coculture and kidney organoid systems) will be used to identify and target cell type-specific metabolic reprogramming. Strategies based on the modulation of these metabolic shifts will provide a firm basis for novel, metabolism-oriented therapeutic approaches against renal fibrosis and CKD.

Mots clés : kidney disease, fibrosis

Participants :
- University Hospital Aachen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
- University Hospital Cologne (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet iRETINA (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Age-related macular degeneration (AMD) encompass the most prevalent cause of vision-loss in elderly people in developed countries. One of the main hurdles restraining the development of efficient treatments against AMD is the inability of current animal, 2D-cellular and organoid-based models to completely recapitulate the pathophysiology of this disease. The goal of the iRETINA project is to bioprint an in-vitro human retinal model using isolated endothelial and retinal cells derived from iPSCs. The result will be a functional and vascularized iPSC-derived tissue resembling the native stratified retina that could serve as a preclinical and toxicological model for drug development and for the study of complex phenomena such as allogenic immune response. In order to achieve this goal, the iRETINA project will focus at three different levels: 1) implementing state-of-the-art genome editing tools for the development of retinal cell differentiation and enrichment strategies from healthy and AMD-patient iPSC; 2) developing new methodologies for bioprinting endothelial and retinal cells aiming to preserve cell viability, synaptic connectivity and structural integrity; 3) proof of concept testing to evaluate the usefulness of the artificial retina as a bona fide in vitro retinal model. The nature of this project is strongly multidisciplinary and involves the collaboration of basic researchers with experts in the fields of ophthalmology, immunology and biomaterial sciences. The results of this proposal have the potential to represent a true technological and scientific breakthrough that will result in better organ and disease modeling, and reduced laboratory animal use, eventually minimizing the burden and complexity of preclinical trials required for the development of novel pharmacological and cell replacement therapies against AMD.

Mots clés : retina, age related macular degeneration, induced pluripotent stem cells, bioprinting, organotypic model systems, genome editing

Participants :
- Bico group ab (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Fundación Progreso y Salud (Espagne) — Coordinator, beneficiary, Recherche, subvention : 206641.2 €
- Democenter (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet DEMSTAT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

My main ambitious is to put at the centre of the debate the Official Statistics in Democracy for Policy-Makers, Researchers and all the citizens. In my experience, I noticed that at times also within the National Statistics Offices (NSOs) they do not know the importance that NSO has for democracy and policy-makers. Democracy dies in darkness without Official Data. Official Statistics is a public good, it is vital for democracy. I want to analyze the empirical and theoretical relation between Official Statistics and Democracy and formalize ten new variables that Official Statistics should produce and disseminate to improve society, economy and the relationship among countries. A key word in my project is the word: ‘multidisciplinary’. Those disciplines are, among others, Statistics, Economics and Political Science. The relation between democracy and Official Statistics is an almost unexplored scientific topic with economical and societal worldwide impact. Media and policy-makers use the official data everyday, because National Statistics Offices (NSOs) are in every single country. The official statistics are produced and disseminated by the NSO. Every day, we listen to the news about the employment rate, the GDP, mortality rate, car accidents, etc. All these statistics are collected, produced and then disseminated by the NSOs around the world. Also, COVID data should be produced and disseminated by NSOs as I explained in one of the top journals on Official Statistics, see Di Gennaro (2020) . Can we organize political elections without an independent and trustable official data produced and disseminated by the National Official Statistics Offices? For instance, trustable data on employment rate and national economic growth (Gross Domestic Product, GDP) are critical for the voters that want to evaluate the government. My research is in line with the value of the European Union and United Nations, and the Sustainable Development Goals.

Mots clés : official statistics, democracy, national statistic office, sustainable development goal, european union values

Participants :
- Université de Malte (Malte) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 201764.4 €
- United Nations Economic Commission for Latin America and the Caribbean (Chili) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Valstybes duomenu agentura (Lituanie) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet SOSeas (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Oil spills rapidly spread on sea surfaces covering wide areas, assuming different appearances and thicknesses. The faster the actions to detect, stop, and contain the released oil from spreading, the higher the Oil Spill Response (OSR) success rate. Since, clean-up effectiveness is higher over thicker layers of oil - referred to as actionable oil - detecting these regions is crucial to enhance oil recovery efficiency, thus minimizing environmental and socio-economic impacts. The objective of "Searching for Oil Spills on Sea Surfaces" (SOSeas) project is to develop an artificial intelligence-based system to extract relative oil thicknesses by using multifrequency and multiresolution Synthetic Aperture Radars (SAR). Aerial reconnaissance is currently the most common method to estimate the extent, thickness, and volume of oil spills. However, it is subjective, biased and imprecise, demanding well-trained experts to visually estimate the extent of an oil slick and distinguish different oil appearances. Conversely, SAR are key-operational sensors for oil pollution monitoring, offering a synoptic view over affected sites, acquiring images during day and night regardless of weather conditions. The use of SAR data to detect the location and extent of oil pollution, as well as to discriminate it from false alarms has been well-researched. However, oil slicks characterization is under-explored, but a promising, new, and highly innovative research area, owing to the increasing availability of free SAR data, the development of powerful learning algorithms combined with high-performance computing advances. An automatic system well-trained to recognize patterns related to qualitative thickness ranging will indicate the actionable oil regions. These outputs can offer a less subjective and more precise oil pollution assessment than that of visual reconnaissance, improving situational awareness in time to guide trustworthy decision-making during clean-up operations.

Mots clés : remote sensing synthetic aperture radar machine learning ocean observation and monitoring emergency response oil spills relative oil thickness

Participants :
- Université de Twente (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
- Collecte localisation satellites (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet IPOCCWWA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

A detailed social history of the women from Egypt’s First Intermediate Period (FIP) needs to be added to the growing corpus of women’s historical narratives. This pivotal period of Egyptian history, the late third millennium BCE, witnessed profound transformations to their social and political structures. These dramatic changes arose from political disintegration and the effects of environmental stresses from climate change at the end of the preceding Old Kingdom period (OK). While the FIP has received broad study, dedicated research into the women from this period has yet to be conducted. Historically, FIP women’s data, derived primarily from biographical inscriptions that sometimes detail their involvement in economic, political, or religious roles (titles), have been subsumed into female title studies of the OK period or discussed in conjunction with the women of the following Middle Kingdom (MK) period. Existing scholarship centres on biographies of exceptional women or significant inscriptions, and women’s details appear more generally in wide-ranging compilations of this historical period. Yet, owing to the unique archaeological and epigraphical evidence of the FIP, it offers the opportunity to examine a broader cross-section of the female population, including levels of society previously absent in other periods. For the first time, the women of the FIP and their agencies will be analysed via a theoretical framework that analyses social power based on the women’s roles and their access to/control over economic, symbolic, and/or political resources. Thus, the objective of this project, The Impact of Political and Climate Change on Women’s Agency: A Social Power Analysis (IPOCCWWA), is to produce a quantitative and qualitative account of the women of the FIP independent from other chronological periods that examines their agency within their distinct historical context and deliver their overdue social history.

Mots clés : women s agency social power informal power social inversion environmental change socio political economic changes cultural transformation

Participants :
- Université Charles de Prague (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 150438.72 €
Projet LeishBlock (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The main objective of LEISHBLOCK is identifying antileishmanial compounds exhibiting minimal mortality to sand flies for exploitation as potential transmission blocking agents. Sand flies are the vectors responsible for transmitting Leishmania parasites, the causative agents of a range of disfiguring to lethal diseases known as leishmaniasis, affecting populations worldwide. Currently, with no human vaccines, disease control relies on reducing contact with the vector and chemotherapy. However, the effectiveness of leishmaniasis-vector control, which includes non-specific insecticide spraying, insecticide-impregnated nets, and environmental management, lags behind other disease-vector-control approaches. Moreover, treatment options for leishmaniasis are limited and often require prolonged hospitalization. To address this pressing public health issue, there is an urgent need to harness existing knowledge on the biology of these parasites, utilize available resources, and explore novel approaches to disease control. Recently, a promising transmission blocking intervention (TBI) has been pursued for vector-borne diseases like malaria, focusing on targeting parasites within the insect vector with a parasiticide. This innovative approach has demonstrated the potential to become a valuable addition to the arsenal of TBIs and merits attention in the field of leishmaniasis. Compounds will be firstly screened using sand fly and bee cell lines. Then, the safest compounds will be individually tested on the respective adult insects. The leading compounds demonstrating greater safety will be assessed for their efficacy in reducing parasite burden in Leishmania-infected sand flies, employing an innovative DNA barcoding approach. The knowledge gained from this multidisciplinary project will contribute to the discovery of urgently needed new drugs to combat this neglected and important emerging vector borne disease, while building on the research profile of the leading investigator.

Mots clés : transmission blocking, drug discovery, leishmania, barcoding, sand flies

Participants :
- Queen Mary University of London (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Swiss Tropical and Public Health Institute (Suisse) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université Charles de Prague (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 309768.48 €