Projet Muscle stress relief (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : CLOSED

A diverse variety of medical or lifestyle conditions lead to a progressive loss of muscle force by functionally impairing myofibril contractility and causing ultimately myofibril loss. Major underlying risk factors of chronic muscle force loss are ageing, inactive lifestyles, and unbalanced nutrition. Together, these factors are predicted to lead to an endemic incidence of muscle weakness both in the developed countries. Clinical research on the mechanisms involved requires a multidisciplinary approach covering aspects of ageing, metabolism, and on the humoral cross-talk of muscle with other key organs including heart, liver, kidney, and lung. To achieve this, six European groups with complementary expertise in inter-organ-cross-talk during stress-induced secondary myopathies will team-up with three leading teams in the U.S. with expertise in myopathy animal models, myofilament proteins and translation of muscle research into therapeutic interventions, and with one team from South Africa with cutting-edge expertise in the regulation of regenerative capacities in muscle. Importantly, five SMEs will participate in this RISE network that provide expertise in early muscle disease detection, monitoring, and the developing preventive strategies: Their knowledge on muscle disease detection at early stages and their monitoring during interventions will promote translational innovation. To implement innovation and our joint research program, both early stage and advanced researchers will be seconded from the academic nine teams to these five SMEs and vice versa. Thereby, this RISE scheme will establish a long-term collaborative University-SME driven translational innovative research program innovation in our interdisciplinary field of growing socioeconomic medical importance.

Mots clés : muscle weakness, sarcopenia and atrophy, critical illness myopathy, myasthenia gravis, diaphragm failure, myofiber force, transgenic mouse models, myology, gene therapy

Participants :
- Stellenbosch University (Afrique du Sud) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Myomedix gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 126000.0 €
- University of Thessaly (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 144000.0 €
- State University System of Florida (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Dld gesellschaft fur diagnostika und medizinische gerate mbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 31500.0 €
- Immundiagnostik (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- University of California System (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Knight scientific limited (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 40500.0 €
- Central Institute of Mental Health (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 9000.0 €
- European Molecular Biology Laboratory (Allemagne) — Partner, beneficiary, Recherche, subvention : 0.0 €
- Tzartos - diagnosis & research in neuroimmunology medical limited liability company (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 166500.0 €
- Arizona's Public Universities (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Liverpool (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Heidelberg University (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 139500.0 €
- Christos papadopoulos & sia oe (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 117000.0 €
- Généthon (France) — Partner, beneficiary, Recherche, subvention : 130500.0 €
- University of Konstanz (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 90000.0 €
- Fondazione per la ricerca biomedica avanzata onlus (Italie) — Partner, beneficiary, Recherche, subvention : 94500.0 €
- Vrije Universiteit Amsterdam (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 180000.0 €
- Plymouth Marjon University (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 189000.0 €