Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CLEAR (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The increased use of pharmaceutical drugs and agriculture chemicals in the last five decades now results in a global contamination of the water cycle. Antibiotics, endocrine disruptors, pesticides are among the most alarming compounds found in wastewaters and even in treated waters. Currently, wastewater treatment plants are the most significant barriers to water contamination, but are known to fail in decreasing micropollutants concentrations to reasonable levels. Consequently, there is an urgent need to implement technologies for removal of micropollutants from wastewaters before they reach rivers, groundwater and marine waters. EDEN MICROFLUIDICS offers a compact, easy-to-deploy, cost-effective technology for micropollutant removal, thus giving access to quality water to the EU and beyond. The system uses microfluidics for treatment of high volume of effluent at low pressures, decreasing significantly energy consumption compared to current techniques. But the fluidic design, while efficient, fails to adapt for the wide range of pollutants and their properties. The fluidic architecture should be dependent on pollutant types, sizes, concentration, ... Designing with such a large array of parameters requires expertise in a specific computational method: Computational Design Optimisation. The objective of the research proposed here is to optimize the design of the devices developed by EDEN by means of computational methods. We will build the necessary physics-based or data-driven models to enable the use of numerical optimization algorithms to determine optimal design solutions for a variety of conditions and requirements. We will employ multidiscisplinary design optimization techniques to account for the interaction of different disciplines entailed in the treatment process, and will also formulate strategies for platform-based design of families of devices to derive different solutions at minimal cost and development lead times.

Mots clés : numerical optimization, multidisciplinary design optimization, platform based product family design

Participants :
- Eden tech (France) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 196707.84 €
Projet COMAMOC (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The increasing ability to manipulate individual quantum systems is leading to a wave of new technologies that have fundamentally superior performance and capabilities for many applications in metrology, sensing, communication, simulation and computing. It is thus identified today as a major axis of research and innovation as apparent from the European Commission decision to launch a Quantum Technology (QT) Flagship. Trapped and laser-cooled atomic ions have in this context proven to be a very important system. Their exploitation within QT is, however, typically limited by their coupling to time-varying stray magnetic fields which shortens the timescale for coherent manipulation. In this perspective, using molecular ions, because they can be made nearly immune to magnetic fields fluctuations, would be advantageous. The complex level structure makes though quantum control of cold molecular ions significantly more challenging. Only this year first deterministic state manipulation of molecular ions, yet within a same rotational manifold, was performed at NIST, USA, in the group of Dr. Dietrich Leibfried. With COMAMOC, I will go step further and drive transitions between different rotational levels with a frequency comb laser. This innovative approach, will be based on my recent achievement in driving the fine structure transition of the Ca+ atomic ion with this technique, in collaboration with Prof. Michael Drewsen at AU. The proposed action, hosted in his group, which has longest experience with cold molecular ions, is a unique opportunity to achieve full deterministic coherent control over the quantum states of a molecule. COMAMOC will open up for many fundamental investigations and technological achievements ranging from test of QED to the use of molecular ions as qubits in ion-based QT. The proposed action is therefore expected to impact the future of the information and communication technology (ICT) market which is foreseen to be quantum in the next few decades.

Mots clés : frequency comb, cold molecular ions, rotational spectroscopy, stimulated raman transition, quantum logic spectroscopy, qubits, coherent manipulation

Participants :
- Aarhus University (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200194.8 €
Projet REACTOMEgsa (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The increasing availability of high-throughput ‘omics technologies results in unprecedented opportunities for precision medicine and biomedical research. With the increasing availability of large amounts of data (‘big data’), data analysis and interpretation have become a major bottleneck. Pathway analysis techniques are used to incorporate existing biological knowledge into the data analysis and allow researchers to focus on the interpretation of regulated biological processes. Despite the existence of many advanced pathway analysis algorithms, most leading pathway analysis resources still rely on simplistic ‘gene set over representation’ analyses (ORA) and cannot integrate data from different ‘omics approaches. Reactome is one of the most popular resources for pathway information. Its open-access data model, powerful web interface, and stringent manual curation and peer-review provide an ideal foundation for this project’s developments. In this project, I will extend Reactome towards an analysis platform for multi-omics biomedical studies. I will replace its current ORA approach with more sophisticated pathway algorithms supporting transcriptomics, microarray, proteomics, and metabolomics data. Next, I will extend Reactome to analyse datasets of samples that cannot be attributed to a phenotype. The extended version of Reactome will be able to derive one expression value per pathway which can then be correlated with clinical parameters to identify clinical relevant biological processes. This will make Reactome a prime resource for multi-omics biomedical studies. I anticipate that the successful completion of this project will allow me to integrate and extend my current skills as a medical doctor and a bioinformatician towards systems biology studies. The additional gained experience in project management and communication of scientific results will form the basis for my envisaged career to start my own interdisciplinary biomedical research group.

Mots clés : pathway analysis, systems biology, proteomics, transcriptomics, biomedical research

Participants :
- European Molecular Biology Laboratory (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 97727.4 €
Projet Inflammafish (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The increasing occurrence of multidrug-resistant Mycobacterium tuberculosis strains makes tuberculosis (TB) a key priority for infectious disease research. Inflammation and autophagy are two fundamental processes critical to TB pathogenesis. Accumulating evidence shows that TB disease is worsened by deregulation of the inflammatory response. On the other hand, autophagy has recently emerged as a crucial host defence mechanism. Autophagy counteracts the ability of mycobacteria to survive inside host cells and targets them for degradation. Autophagy is also thought to control the inflammatory response. However, the interaction between inflammation and autophagy in host defence against TB remains unclear. The aim of my proposal is to use the well-established zebrafish model of TB to gain insight into this key question. Recently, the host laboratory discovered that the DNA damage-regulated autophagy modulator (DRAM1) protects against TB in the zebrafish model. They also implicated this important autophagy regulator in inflammation, as it strongly affects expression of interleukin-1beta (IL1B). I have specific expertise in studying IL1B-mediated inflammation in zebrafish. Thus the proposed project will be a great synergy between me and the host laboratory, which is leading in zebrafish infectious disease research. I will determine how modulation of autophagy or manipulation of IL1B levels reciprocally influence each other during TB disease. The zebrafish model provides excellent tools to visualize these processes in vivo. Furthermore, I will take advantage of the host’s expertise in RNA sequencing and proteomics to study genome-wide effects of autophagy modulation on the inflammatory response. A secondment will allow me to compare results in the TB model with a damage-induced inflammation model. The project will provide new insights into regulatory pathways that could potentially be intervened in treatment of TB or other inflammatory diseases with common characteristics.

Mots clés : infection, tuberculosis, host defence, zebrafish model, anti bacterial autophagy, inflammatory response

Participants :
- Leiden University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet WiVi-2020 (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

The industrial telecommunications sector stands currently at the forefront of a new era, which is marked by the transition to the new generation of wireless communications, namely the rise of 5G. With the recent explosion of the Machine-to-Machine (M2M) communications and the Internet-of-Things applications, the internet traffic is growing exponentially. Future networks should support applications with extremely variant Quality of Service (QoS) requirements, from low throughput and generally medium delay (M2M) to very high throughput and low delay (high definition real-time video). These challenges have not been yet addressed in network deployment within buildings, resulting in very low quality mobile access perceived by indoor users. WiVi-2020 aims to develop an architectural framework and respective mechanisms for the next generation of indoor mobile/wireless communications. The goal is to investigate the deployment of heterogeneous Radio Access Technologies using the advances of Software Defined Radios/Networks with a specific aim to meet the end-to-end QoS requirements of differentiated services adopting the concept of Application Defined Networking. The need for advancement along these lines demands cutting edge research and development efforts with a strong focus on industrial requirements that pave the way towards 5G. WiVi-2020 mobilizes a joint industry-academic group towards training the next generation of researchers (or “visionaries”) in multidisciplinary areas, setting the foundations for future mobile communications. In this respect, WiVi-2020 will evolve from traditional specialized training on a narrow area adopting a strong research and doctoral training programme with the direct involvement of the industry for better matching public and private sector needs. This way, WiVi-2020 will create researchers who are highly-skilled in the production of novel fundamental knowledge, with the ability stimulate entrepreneurship, creativity and innovation.

Mots clés : wireless network optimization, software defined radio, software defined network, indoor network planning, 5g communications, application defined networks, research and training, innovation

Participants :
- Vodafone (Greece) (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 484773.84 €
- Foundation for Research and Technology Hellas (Grèce) — Coordinator, beneficiary, Recherche, subvention : 484773.84 €
- Linköping University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 527318.64 €
Projet Old and New (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The influence of a the new medium of print on the old, existing medium of handwriting has never been examined before. The printing press came already around 1530 to Iceland and the earliest printed books were strongly influenced by handwritten manuscripts, which is well documented. A phenomenon which has not yet been analysed is that, as time went on, books in return influenced manuscripts. Manuscript production did indeed not stop after 1530, but grew to new quantitative and qualitative heights, including features of printed books such as title pages. I therefore propose to conduct a study on the relationship between books and manuscripts of the 16th and 17th centuries. The focus will be on title pages, as they are a truly innovative feature of printed books that we also find in post-Gutenberg manuscripts. The objectives of this project concern: a) The influence of a new medium on an existing medium b) The utilisation of features of the new medium to achieve specific aims and goals c) The impact of this utilisation on society Methods to conduct the study of title pages and their sociological impact include content analysis from literary studies, quantitative codicological analysis from book and manuscript studies, and iconographic/iconologic analysis from art history. This project has ground-breaking potential. It will provide insight into the ways features of new media were incorporated into existing media and how they were utilised. It will be the first systematic survey of its kind in Iceland and, concerning the influence of printed books on post-Gutenberg manuscripts, internationally. It will also be one of the first systematic interdisciplinary studies. It will be the forerunner of a larger project about Icelandic book and manuscript history and media changes with more researchers involved. The beneficiary has perfect conditions for interdisciplinary research and career development at the host institution and secondment and will complete the first step toward a full professorship.

Mots clés : icelandic manuscript culture, icelandic print culture, media change, media and society

Participants :
- Austrian Academy of Sciences (Autriche) — Coordinator, beneficiary, Recherche, subvention : 166156.8 €
Projet DIGISTRAT (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

The innovative research project tackles acute questions of organisational renewal capacity and change management in the radically changing media sector. The key question is how media organisations can renew their thinking, resource bases and capabilities in order to stay competitive while addressing the challenges of digitalisation. The research is carried out by conducting qualitative and quantitative analyses based on data collected in the German media industry. The media context offers an excellent example of a dynamic business environment brought about by technological convergence, rapidly changing media usage behaviour and increasing global competition. The theoretical framework is based on modern theories of strategic management research, especially in relation to the dynamic capability view and the managerial cognition tradition. The combination of the two frameworks forms a unique multidisciplinary research approach that comprehensively helps European media organisations tackle organisational path dependencies and drivers of change. Understanding the factors that keep the media industry competitive is of great importance, because vital and diverse media is a key element of European democracy. The project is a pioneering piece of research into media management and opens many new options for projects and international collaboration as well as applications in other industries facing digital transformation. The unique interdisciplinary approach and research setting combined with a highly important topic of European interest remarkably improves the senior researcher’s competencies through applying new theories and analysis methods. The project also extends her teaching skills through opportunities at the host institution related to strategic management and the media sector than at her home university. As a result the fellowship considerably widens her career opportunities, especially as the study will spur wider interest in both academia and practice.

Mots clés : strategic management, dynamic capabilities, media industries, digitalization, business models, competitiveness, organizational renewal

Participants :
- Jade University of Applied Sciences (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 174806.4 €
Projet DSB Architect (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The integrity of eukaryotic genomes is constantly challenged by various endogenous and exogenous insults, whereby DNA double-strand breaks (DSBs) are particularly problematic. DSBs can be repaired by multiple pathways, but only the homologous recombination (HR) pathway ensures error-free repair. HR restores missing information around the lesion based on topological interactions with a homologous region on a distinct DNA molecule. HR-directed repair can function across homologous chromosomes in diploid organisms, but is much more efficient between sister chromatids in replicated chromosomes, indicating an important role of chromosome conformation in repair. Sister chromatids are organized by a dynamic interplay between cohesin-mediated loop extrusion, cohesin-mediated sister linkage, and chromatin-based affinity interactions. How these activities shape sister chromatids to support DNA repair is unclear. The proposed project aims to reveal how sister chromatid conformation governs DSB repair efficiency and pathway choice in human cells and to identify and characterize the key molecular factors regulating chromosome conformation for efficient DSB repair. Understanding how intra- and inter-molecular topological interactions contribute to DNA repair will become possible by using a new chromosome conformation capture technology developed in the hosting lab (sister-chromatid sensitive Hi-C). This technology will be combined with a system for acute DSB induction, automated imaging and genomic profiling of DNA repair factors, and targeted protein degradation of cohesin and its regulators to elucidate topological interactions underlying DSB repair. The proposed project will provide insights into how the core machinery shaping the three-dimensional organization of chromosomes contributes to the maintenance of genome integrity.

Mots clés : chromosome conformation, sister chromatids, cohesin, dna damage, dna double strand break repair, homologous recombination

Participants :
- Austrian Academy of Sciences (Autriche) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 174167.04 €
Projet Phycosphere Fe (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The interaction between metals and microscopic plant-like organisms called phytoplankton is a key link to global carbon balance. More than a half of atmospheric CO2 on earth is taken up by phytoplankton, but iron (Fe) limits their growth in large regions of the oceans. Ongoing ocean acidification and global warming will influence Fe-stress in marine phytoplankton and hence the biological carbon fixation. Key existing knowledge gaps are the pathways by which phytoplankton take up Fe, and influences of chemical conditions in the microenvironment surrounding algal cells (i.e., phycosphere) on Fe speciation and bioavailability. This knowledge represents an impediment to understanding the complex effects of climate change on Fe uptake and oceanic carbon fixation. The project ‘Phycosphere Fe’ will determine chemical conditions and Fe speciation in the phycosphere of model phytoplankton species, quantify the role of phycosphere Fe speciation in Fe bioavailability, and investigate influences of climate change (i.e., warming and increased CO2) on Fe-algae interfacial processes. The project is key to the assessment of Fe bioavailability, growth and CO2 fixation of phytoplankton in current and future oceans, which make key contributions to global carbon sequestration. The project will improve our ability to model phytoplankton dynamics and predict biological carbon fixation in a changing ocean.

Mots clés : trace metals, bioavailability, metal speciation, algae, phytoplankton, uptake

Participants :
- GEOMAR Helmholtz Centre for Ocean Research Kiel (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 174806.4 €
Projet InterTJRPB (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The interplay between transitional justice and reconciliation processes in peacebuilding is still a rather empirically under researched issue. Existing literature on these processes and their relationship has remained normative, as most studies have lacked an examination of their overall effectiveness, and have not attempted to compare the impact such processes can have on society, at large, across different countries. The result has been a knowledge gap, which has produced decision-making based on weak data, ex-ante evaluation and speculation. Although there are some important insights from various single cases, we still need more in-depth empirical and theoretical inquiries, as well as comparison between cases, in order to explain how the interplay between transitional justice and reconciliation processes works in practice across different contexts. This research project aims to address this gap through a comparison of how various transitional justice and reconciliation mechanisms function and how their combination affects peacebuilding, either positively or negatively, across two countries—Algeria and Rwanda. Methodologically, the project’s design is that it is a comparative qualitative case study that proposes to use a novel methodological approach of participatory visual methods combining photo-voice and art, along with elicitation and auto-driving. This novel method in peacebuilding is to be combined with interviews and documentation to ensure triangulation of evidence.

Mots clés : conflict transformation, reconciliation, transitional justice, peacebuilding, violence, algeria, rwanda

Participants :
- Coventry University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €