Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SIR (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Corruption is a pressing global challenge, which imposes substantial costs on the lives of people and businesses, and undermines citizens’ trust in democratic institutions. Anticorruption reforms and political ethics regulation have also grown dramatically in European countries, but display varying degrees of success. While scandals, policy diffusion and political will have been advanced as explanations for the success or failure of anticorruption policies, it not yet understood under which specific conditions politicians will adopt anticorruption policies (ACPs) aimed at changing their own status quo and conduct. If we don’t know the answer to this question, then anti-corruption efforts are doomed to failure. Unlike previous studies that focused on the implementation of broad anticorruption reforms in the public sector or on the behaviour of participants acting out the part of policymakers in controlled laboratory experiments, the novelty of the SIR project is that it will investigate the specific conditions that surrounded the adoption of each anticorruption law aimed at political officials, namely party funding, conflict of interest and lobbying. The focus on policies will allow the research to go beyond simple national variations and grasp the conditions under which the policies were adopted in any given time. This research will be divided into two phases: i) the creation of an original database with the contextual conditions surrounding the adoption of ACPs and the adoption of GRECO recommendations in EU countries; ii) quantitative and qualitative comparative analysis of the contextual conditions surrounding the adoption of each specific ACPs dedicated to political office holders.

Mots clés : corruption anticorruption qca public policy elites comparative politics politics

Participants :
- Université d'Europe centrale (Hongrie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de la ville de Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet CHRISALIS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Intersex/variations of sex characteristics (I/VSC) are terms that refer to bodies born with biological sex characteristics that vary from what is typically thought of as exclusively male or female. VSC differ widely from individual to individual, and statistics estimate that up to 1.7% of infants are born with these natural variations in human biology. They do not ordinarily impair life or physical health. However, social norms and cultural expectations result in a perceived ‘urgency’ to intervene medically and surgically to reshape I/VSC bodies so that they appear to be male or female. Reports suggest that such interventions in early childhood can impact negatively on the health and life of those with I/VSC. As a contribution to the recent social, medical, ethical and juridical debate on the topic, CHRISALIS is an interdisciplinary, multijurisdictional project employing qualitative epistemology and mixed-methods design to investigate the effects of ethical-moral beliefs and culture in shaping intersex experiences, bodies and healthcare in Ireland and Italy. As there is no holistic multidisciplinary understanding of I/VSC and existing guidelines vary depending on the primary perspective, this project intends to highlight yet unheard and unknown intersex experiences, in order to lay the foundation for the development of national and European Intersex policies, wider European cross-cultural studies and support the new and vibrant field of Intersex Studies.

Mots clés : politics of gender, race, discrimination, and inequalities identity politics

Participants :
- The Open University (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de la ville de Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet Bezzagood (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

While hydrogen is an excellent green energy carrier, which holds tremendous potential as a sustainable, environmentally friendly, efficient, and clean energy alternative, its storage remains costly, energy-intensive, and hazardous. Recently, the possibility of chemical storage of H2 in the form of ammonia (NH3) is receiving increasing attention. However, despite the potential of NH3 for hydrogen storage the existing fossil fuel-based NH3 production technology is highly energy intensive and costly. Photocatalytic NH3 synthesis is gaining familiarity as it is environmentally benign and sustainable, however, the conventional photocatalysts suffer from low NH3 yield, poor photocatalyst operational stability, and low solar-to-chemical conversion efficiencies, thus it is the current scientific challenge to design an efficient photocatalyst to convert atmospheric N2 to NH3. Hence, the design and construction of novel hybrid photocatalysts with enhanced photocatalytic performance is vital for efficient synthesis of ammonia as a hydrogen energy storage medium. In recent years, the two-dimensional transition metal carbides, carbonitrides and nitrides ( MXenes), are gaining popularity for photocatalytic N2 reduction owing to their diverse elemental compositions, large surface area, light-harvesting ability, and capability to host a broad range of intercalants. Besides heterojunction formation by combination of MXenes with 3D reduced graphene oxide (rGO) and other novel photocatalysts such as Metal–Organic Frameworks, Z-scheme photocatalysts would significantly increase photocatalytic performance of the hybrid by combining the merits of each component. Besides the interconnected structure of 3D rGO framework possesses a macroscopic porous structure, for efficient incorporation of semiconductor nanoparticles in the 3D structure. Thus, the current study designs and fabricates innovative 3D MXene-based hybrid photocatalyst for efficient photocatalytic synthesis of NH3

Mots clés : hydrogen energy ammonia nh3 for hydrogen storage 3d hybrid photocatalysts for efficient nh3 synthesis safe, cheaper hydrogen carrier chemical mxene based 3d heterojunction hybrid catalysts

Participants :
- Laboratoire fédéral d'essai des matériaux et de recherche (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Coimbra (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 156778.56 €
Projet ELLIPSIS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Genetic lethal interactions, which describe the lethal effect of combined perturbations in two or more genetic factors whilst individually have no effect, have emerged as a significant topic in the field of targeted cancer therapy. Despite their promising performance in clinic, current genetic lethality-based therapies focus mainly on digenic interactions restricting the size recipient patients. Complex genetic interactions that involve deregulation of innate mechanisms or cellular responses offer an alternative approach in the development of anti-cancer therapy. Impaired licensing of DNA replication represents a common feature of cancer cells fuelling genomic instability. Cancer cells manage to proliferate and expand under conditions of impaired licensing suggesting that have acquired special mechanisms that are not present in normal cells. Here, my aim is to unveil genetic interactions that induce lethality by investigating the mechanisms that enable the survival of licensing-defective cancer cells. Using colorectal cancer as a model, I will first identify the genes that are overexpressed in tumour cells that exhibit licensing defects. Secondly, I will interrogate the consequences of genes inactivation in the survival of cells by employing a CRISPR/Cas9 screen in a cell system of inducible licensing defects by the overexpression of the licensing factor Cdt1. Finally, the identified hits will be validated through functional experiments in cell systems and model organisms to establish their lethal effect. Our results will identify novel factors that upon inhibition induce the selective cell death of cancer cells and we anticipate that they will be attractive targets for future studies on drug design and development.

Mots clés : replication licensing, cdt1, crispr cas9

Participants :
- Université de Patras (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 197263.68 €
- Wellcome Trust (Royaume-Uni) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet POLEM-WO (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The aim of this project is to explore the contribution of women philosophers to twentieth-century political thought. While women’s work is currently being rediscovered in all fields of knowledge, they are still marginalized in the history of political thought, since politics has traditionally been considered a male domain. POLEM-WO: “Reframing the Relationship between War and Politics with 20th Century Women Thinkers” aims to fill this gap in European intellectual history by examining the relationship between war and politics – 'polemos' and 'polis' – in the work of major European thinkers, namely, Hannah Arendt, Simone Weil, María Zambrano, and Rachel Bespaloff. The project will draw on their writings on the most pressing issues of their time – the rise of totalitarianism, the role of Europe, Jewish identity, the reconstruction of a democratic future – to perform a critique of the traditional bond between politics and violence. The result will be an original examination of the European tradition with the aim of producing a renewed political lexicon – one based on hospitality, friendship, vulnerability, plurality, 'xenophilia' – as a conceptual resource for confronting a present challenged by war, the global shift to populist politics and the refugee’s crisis. Using the methods of political theory, gender studies, archival research, and digital humanities, POLEM-WO has a twofold objective: on the one hand, it will point out the gendered nature of traditional political notions, while enlarging the semantical spectrum of politics; on the other hand, it will produce a non-canonical understanding of key categories such as politics, war, peace, and democracy. The project will make its results available to scholars and the public, thus contributing to the strengthening of a diverse and inclusive imaginary within the framework of a shared European identity.

Mots clés : history of political thought, political philosophy, contemporary philosophy, contemporary jewish philosophy

Participants :
- The new school (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Bologne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €
Projet TransISLES (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

During the 19th century, economic changes (expansion of trade networks and industrialisation) and geopolitical shifts (decline of the Ottoman Empire and rise of nation-states) reshaped the socioeconomic structure of Eastern Mediterranean islands, leading to both new opportunities and the decline of traditional economic activities. Transformations of Island Societies in the Eastern Mediterranean (1830-1911): a Three-Case Study Analysis (TransISLES) proposes a pioneering comparative study on the socioeconomic changes of nineteenth-century island societies in the Aegean and Ionian archipelagoes. The project focuses on three small islands – Thera (Santorini), Tinos, and Ithaca – each of which exhibits distinct political, economic, and social characteristics, integrated into different sea regions and trade networks, serving as representative case studies for Eastern Mediterranean. Using as the main indicator of analysis the family unit in its demographic, social, economic, and material context, TransISLES aims to examine how transformative processes in the Eastern Mediterranean affected the socioeconomic fabric of these islands, revealing differences and commonalities across geographical areas and social groups. The project adopts an interdisciplinary approach that combines maritime history, island studies, family history, demographic history, gender studies, and material culture studies, together with the integration of digital humanities tools. Through a two-tiered analysis, merging macro-level quantitative studies of demographic and occupational data with micro-level examinations of individual families, TransISLES will explore the evolution of social and economic hierarchies, patterns of social mobility, cultural perceptions of socioeconomic status, and gender regimes on these islands. TransISLES will address critical research gaps and offer a groundbreaking contribution to understanding how island societies adapted to significant political and economic changes.

Mots clés : maritime history, island studies, nineteenth century transformations, industrialisation, nation state building, material culture studies, family history, eastern mediterranean, mediterranean history

Participants :
- Université de Gênes (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209483.28 €
Projet TASTeM (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

An unhealthy diet is a major contributor to chronic disease and mortality worldwide. A shift toward healthier food choices is therefore essential to reduce the burden of diet-related diseases. A critical factor driving food choices and ultimately dietary habits, is flavour, which is a complex combination of sensory properties, including taste, aroma, and mouthfeel. Astringent mouthfeel is a tactile sensation characterised by a puckering, rough, or drying feeling in the mouth, often associated with foods and beverages with significant health benefits, including plant-based products. While plant-based diets are generally considered healthier and more sustainable than animal-based diets, their astringent properties frequently lead to consumer rejection. Overcoming these sensory barriers is key to promoting plant-based foods for both health and environmental sustainability. Previous studies show that astringency is triggered by the interaction between phenolic compounds in plant products and salivary proteins or oral epithelial cells. However, the exact mechanosensory pathway for astringency perception remains unclear. This project aims to uncover the fundamental mechanisms behind astringency perception, focusing on mechanosensation, through an interdisciplinary approach that combines molecular, biophysical, and physiological strategies. The study will identify specific mechanoreceptors on oral cells and investigate how phenolic compounds interact with components of the oral cavity. Atomic force microscopy will be the core technique to investigate mechanoreceptor activation, while sensory studies will explore ingredient replacements or additives to improve mouthfeel without compromising health benefits. As such, this project aligns with the Sustainable Development Goal number 3 – “Good health and well-being” – set out by the United Nations, by providing valuable insight into the development of more sustainable dietary patterns, while promoting long-term health benefits.

Mots clés : flavour, mouthfeel, astringency, atomic force microscopy, afm, ion channels, mechanoreceptors, piezo2, perception mechanisms, phenolic compounds, astringent compounds, mechanosensitive, biophysics

Participants :
- Leibniz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 202125.12 €
- Rede de Química e Tecnologia (Portugal) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet EMMA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This research project proposes a trans-imperial historical analysis of the agency, ecology and representations of European subalterns in Tunisia and Libya during the colonial period. The presence of marginalised Europeans, mainly from Southern Europe, in Tunisian and Libyan societies challenged the dichotomy dividing the colonisers from the colonised. This colonial liminality is the fulcrum of the project “European Marginals in Mediterranean Africa: Race, Space and Environment in Tunisia and Libya (1881-1950s)” (EMMA). The chronological analysis framework spans the French occupation of Tunis in 1881 to the end of colonial rule in Libya (1951) and Tunisia (1956). The aim is to analyse the intermediate and ambiguous position of these subalterns to show not only the slippery boundaries of a ‘White’/‘non-White and ‘European’/‘North African’ identity in a Mediterranean colonial context but also how entangled these identities are with social, political and ecological frontiers and perceptions. This goal will be achieved by an interdisciplinary approach that encompasses cognate field of social sciences as history and anthropology. For this reason the project is under the joint supervision of professor Francesca Biancani, MENA area scholar from UNIBO, specialist on gender and colonial North African history; and professor Naor Ben Yehoyada, social and cultural anthropologist at CU, specialist on Mediterranean mobility. This interdisciplinary project is based on multi-archival research encompassing sources from colonial, national and private archives and journals, press and publications in Tunisia, Italy, France, United Kingdom, Malta; it consists in 7 work packages dedicated to training, management, research, dissemination and communication activities.

Mots clés : mediterranean, colonialism, subalterns

Participants :
- Université Columbia (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Bologne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €
Projet COLOUR (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

Photonic pigments are one of the most exciting topics in optics as they are expected to lead to a pure and brilliant colouration free from chemical- or photo-bleaching, which is a central goal in the future developments of paints, cosmetics, displays, and advanced photonic devices. Till now most efforts have been focused on amorphous packings of colloidal crystals, but limitations of synthesizing large quantities of photonic pigments based on these arrays are only beginning to emerge. Novel materials and approaches are thus necessary and, in this context, COLOUR aims to develop bio-inspired photonic pigments via the combination of structural colouration and light absorption. The key approach is to exploit the 3D self-assembly of block copolymers in concentric lamellar structures to generate full-spectrum photonic crystals with high reflectivity and angular independence, coupling these with broad-band absorbers to ensure colour purity and vividness. Specifically, high-visibility structural colour able to address the limitations of current photonic pigments will be achieved by altering four variables, namely size, blackness, refractive index, and arrangement of the nano-elements. COLOUR will rely on my competencies in polymer processing and characterization and the expertise of the host supervisors Prof. Ullrich Steiner and Prof. Christoph Weder in the domain of soft matter physics, polymer self-assembly, supramolecular polymers and materials science (outgoing phase, Adolphe Merkle Institute, University of Fribourg - Switzerland), and Prof. Davide Comoretto in photonics (incoming phase, Department of Chemistry and Industrial Chemistry, University of Genova – Italy). COLOUR offers me the unique opportunity to acquire technical skills and experiences in several scientific fields that will be crucial to advance my career towards an independent academic position, as well as exposure to a technological problem of significant scientific, societal, and technological impact.


Participants :
- Université de Fribourg (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Gênes (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 297164.16 €
Projet UNMET (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

An estimated 25-50% of colorectal cancer patients will encounter liver metastasis during their illness. Tumor vessel co-option is a non-angiogenic mechanism whereby tumors, rather than forming new blood vessels (a process known as angiogenic growth), hijack pre-existing blood vessels in the affected organ. Standard anti-angiogenic therapy (AAT) is ineffective against vessel co-optioned tumors. This process has been linked to unfavorable patient outcomes. The exact mechanisms distinguishing vessel co-option remain elusive. Preliminary data suggest that metastatic cancer displaying the vessel co-option phenotype increased in gene expression, regulated by Lymphoid enhancer binding factor 1 or LEF1 protein, which is a key mediator of the Wnt/β-catenin signaling. The dysregulation of the Wnt pathway can activate target genes that promote cell proliferation and survival. In this proposal, I hypothesize, that inhibition of the Wnt signaling (e.g. by blocking LEF1), will change the properties of vessel co-optioned tumors and improve the effectiveness of conventional treatment for liver metastases. Patient-derived organoids, obtained from hospitals, will be used to validate whether the inhibition of LEF1 will impact the vessel co-option phenotype, making it more susceptible to AAT. Advanced microscopy techniques, like Atomic force microscopy and Scanning ion-conductance microscopy, will facilitate monitoring the decreased stiffness of vessel co-opted tumor cells, leading to improved AAT delivery. By using humanized patient-derived organoid xenografts with inhibited Wnt signaling, I will monitor tumor growth, its phenotype, and the response to AAT in vivo. Furthermore, I aim to pinpoint diagnostic markers for vessel co-option tumors using blood tests and computed tomography (CT) scans. Utilizing artificial intelligence tools, I plan to analyze CT scans of liver patients to better predict metastatic tumor subtypes and treatment responses in the future.

Mots clés : colorectal cancer liver metastases vessel co option sprouting angiogenesis anti angiogenic therapy

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €