Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SELECTION (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Each year, millions of infections are acquired in healthcare facilities. The hospital water environment (including sinks, showers and toilets) are now recognised as important environmental drivers of these infections- many of which can be prevented by hygiene and infection control measures, including effective cleaning. However, the most effective methods of cleaning the hospital water enviroment are still not known, so current practices may not prevent infections. Concerningly, recent evidence has emerged suggesting that current practices may inadvertently alter the bacterial population in these environmental reservoirs- potentially causing harm to patients. Furthermore, current practices rely on the widespread use of chemical disinfectants, which have ecological and environmental consequences. With the support of the Marie Skłodowska Curie Actions programme, SELECTION will develop a novel and environmentally considerate method for hospital sink cleaning. SELECTION will first optimise this method under controlled experimental conditions. A study will then be undertaken in a hospital setting to compare this novel approach with current cleaning practices. To understand the effectiveness of these interventions, we will measure the amount of bacteria present in sinks when cleaned with these different methods, and also use metagenomics and bioinformatics approaches to charecterise how different cleaning interventions change the microbial population within these reservoirs. We will interview healthcare workers involved in the implementation of cleaning interventions in the hospital (including cleaning staff, healthcare engineers and infection prevention and control specialists) to understand their perceptions of the novel intervention and outline the roadmap and barriers to implementation in healthcare settings beyond this research study. SELECTION will inform hospital cleaning strategies and infection prevention and control practices.

Mots clés : infection prevention and control, hosptial acquired infection, cleaning and decontamination, antimicrobial resistance

Participants :
- Université de Virginie (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet ArbEvo (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Language is one of the greatest mysteries in the evolution of humankind. It is a remarkable phenomenon that appears to be distinct from other animal communication system, and yet its evolutionary roots remain far from clear. One interesting feature of human language, that does not seem to exist in other communication systems, is the arbitrary relationship between form and meaning. In recent years, many studies have emphasised cases of non-arbitrariness, such as iconicity, and pointed to its advantages for communication, but the merits of arbitrariness itself are rarely considered. This project takes a novel perspective and aims to demonstrate the potential advantage of arbitrariness, in order to elucidate it as an evolutionary adaptive behavioural trait. The specific proposal is that arbitrariness supports communication under noisy conditions. A combination of cross-linguistic comparison, laboratory psycholinguistic experiments, and computational modelling will illuminate the role of arbitrariness in efficient communication. It will demonstrate how decoupling form and meaning reduces ambiguities, when context is available, and explore the effects of various types of naturally occurring noise. The project aims to further demonstrate the role of another quality of arbitrariness: that is, the induction of a discrete communication system. This has consequences for the emergence of complex linguistic characteristics, such as syntax and compositionality. By integrating ideas from distinct fields, such as the evolution of animal communication, and cross-cultural and cross-linguistic human studies, the project has the potential to set forth a novel theory about key aspects of the evolution of language.

Mots clés : language evolution iconicity arbitrariness systematicity cross linguistic categories concepts

Participants :
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet UbADPrLINK (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Intricate networks of post-translational modifications (PTMs) shape how cells respond to environmental threats. Adenosine diphosphate (ADP)-ribosylation (ADPr) has emerged as a pivotal PTM elicited by DNA damage or host immune responses to combat viruses, including SARS-CoV-2. This protective ADPr signature can be regulated by PARP14, a versatile enzyme that can both install and remove ADPr. While the connection between ADPr signalling and these damaging events is clear, the physiological targets and functions of PARP14-mediated ADPr remain ill-defined. Recently, a cryptic link between PARP14 ADPr and ubiquitylation signalling has arisen, adding complexity to PARP14-regulated processes. This ambitious research program ‘UbADPrLINK’ aims to dissect the mechanistic underpinnings of PARP14 ADPr and its link with ubiquitylation using an integrative approach, merging proteomics, structural, biochemical methods. UbADPrLINK will focus on four areas. First, we will precisely map and characterise cellular PARP14-catalysed ADPr sites on important targets by reconstituting ADPr in vitro. Concurrently, we will study the structure-function relationships of PARP14 and explore the roles of uncharacterised PARP14 domains and auto-modification in regulating its activity. Next, we will attempt to decipher the interplay between PARP14 and the PARP9-DTX3L complex that is known to regulate PARP14 activity using unclear mechanisms. We will structurally characterise the PARP14-PARP9-DTX3L complex and assess its potential to simultaneously modify targets with ADPr and ubiquitin. Finally, we will launch a drug discovery campaign to discover cyclic peptides capable of modulating SARS-CoV-2 by targeting PARP14 and SARS-CoV-2 domains involved in ADPr during infection. By seeking to unravel the molecular details of PARP14-catalysed ADPr, UbADPrLINK has the potential to advance our understanding of ADPr signalling beyond the state-of-the-art and may contribute to the development of new therapies.

Mots clés : adp ribosylation, parp14, post translational modification ptm , ptm crosstalk, ubiquitylation, dna damage, antiviral immunity, sars cov 2, structural biology, biochemistry, proteomics, drug discovery

Participants :
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet MESK (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Modelling the Earliest Human Settlement in the Kattegat-Skagerrak Circumference (MESK) is an interdisciplinary project that will investigate the earliest human settlement along the coastline of Kattegat and Skagerrak in present-day Denmark, Sweden and Norway. This will be done by addressing three fundamental challenges that currently hamper our understanding of the earliest peopling of Scandinavia: (1) Chronological control pertaining to the deposition of the archaeological material, (2) variability in coastal engagement and settlement patterns in regions of varying topography, characterised by dramatic changes due to deglaciation and sea-level change, and (3) the degree to which lithic artefacts associated with the settlements are indicative of cultural differences within the region. Due both to research-historical circumstance and modern organisation of the research sectors, our understanding of the Late Glacial and Early Holocene human dispersal and settlement of Scandinavia continue to be influenced by present-day national and administrative borders. To overcome this issue, MESK will involve the application of reproducible computational methods to pan-regional datasets with the research objectives of (1) analysing coastal settlement patterns relative to the contemporaneous shoreline to assess the coverage and reliability of the archaeological dating method shoreline dating, and (2) employ quantitative methods to taxonomically classify lithic armatures that have traditionally been described qualitatively to define archaeological cultures that are discretely bound in time and space. The project is uniquely positioned to provide a nuanced understanding of how people of the deep past settled in previously uninhabited regions, how they adapted to an at times dramatic sea-level change and will provide researchers concerned with similar questions with tools for implementing shoreline dating, thereby improving our chronological grasp on these key processes of our past.

Mots clés : chronology relative sea level change settlement patterns geometric morphometrics cultural evolution stone age scandinavia

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 247553.28 €
Projet Nano-Synergy (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

As a Marie Skłodowska-Curie (MSC) fellow, I aim to engineer clinically focused mRNA formulations for rewriting the biology of synovial cells and unlocking regeneration in rheumatoid arthritis, and expand the capabilities of current Disease Modifying Anti-Rheumatic Drugs (DMARDs). The current first-line therapies for rheumatoid arthritis (RA), DMARDs, effectively manage inflammation but do not regenerate destroyed bone tissue, leading to lifelong disability and pain. We hypothesize that reprogramming specific synovial cell types by combining targeted mRNA delivery with approved DMARD therapies can restore the pathological tissue state in arthritis back to a healthy state and enable long-term joint repair. This project, Nano-Synergy, will be supervised by global leader in materials chemistry and tissue engineering Prof. Dame Molly Stevens at the Kavli Institute for Nanoscience Discovery (University of Oxford). I will collaborate with tissue biologists Prof. Chris Buckley and Prof. Mark Coles at the Kennedy Institute of Rheumatology (University of Oxford), the world’s premiere rheumatology research centre. In the host Stevens group, I will rationally engineer mRNA nanodelivery systems which specifically deliver payloads to joint synovial cells by using bio-orthogonal chemistry and revolutionary techniques for characterizing nanoparticle physicochemical properties. I will demonstrate that mRNA synergizes with DMARDs to reprogram arthritis at the cellular level by adapting a state-of-the-art organoid system utilized by Buckley and Coles which spatially and transcriptionally recapitulates human arthritis, and then demonstrate tissue regeneration using an animal model. In summary, as a biomedical engineer and immunologist trained in RNA delivery and animal models of tissue injury, I will integrate unrivalled expertise and capabilities in engineering and rheumatology at Oxford to pioneer new regenerative therapies.

Mots clés : synovium, fibroblast, nucleic acids, inflammation, resolution, lipid, rheumatology

Participants :
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet POPCOT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This project investigates the creation and circulation of conspiracy theories in revolutionary-era Western Europe (1789-1848), adopting a transnational angle that focuses specifically on France, Britain, and Italy. It aims to understand why historical actors created conspiracy theories; why these narratives resonated with wide audiences; and what social and political impact they had. The project will trace the emergence across Europe of a shared conspiracy culture, which interpreted major historical developments and global history at large as being driven by the schemes of a small, international cabal of plotters seeking world domination. It will examine why some sociocultural and national contexts proved particularly conducive to the spread of conspiracy theories while others exhibited greater resistance, and it will explore why conspiracist beliefs thrived in times of revolution. The analysis will address the impact of conspiracy theories on the development of democratic systems, their role in processes of mass mobilisation, and their contribution to violence against political, religious, and racial minorities. Drawing on recent scholarship in intellectual, social, and cultural history and the history of emotions, this project distinguishes itself through its unique transnational lens and its broad chronological scope, and for incorporating insights from other disciplines, including literary and communication studies and anthropology. As conspiracist tropes spread widely across the globe and influence electoral processes, this project provides a timely contribution to historical scholarship and to ongoing discussions on the fight against misinformation that are taking place in academia, journalism, and policymaking, thus addressing one of the priorities of the European Commission’s Digital Services Act. It will also enhance the fellow’s research profile, positioning him ideally to secure a tenure-track position.

Mots clés : age of revolutions conspiracy theories europe french revolution history of emotions eighteenth century nineteenth century france italy britain

Participants :
- Université de Warwick (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet SimDalitzCPV (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The amount of CP violation in the Standard Model (SM) of particle physics is not sufficient to explain the matter-antimatter asymmetry in the Universe, and thus searching for new CP-violating sources beyond the SM is of high priority in particle physics. The goal of this fellowship is to address this challenge by performing a novel measurement of CP violation simultaneously in the Bs -> KS K+ pi- and Bs -> KS K- pi+ decays. The two decays have dominant contributions from the b->s loop transition to which New Physics (NP) effects could have sizable contributions. The method will first be developed with a standalone study. This will investigate several factors that can affect the precision of the measurement of CP-violating observables in Bs -> KS K+- pi-+ decays, including the sample size and the amplitude model variations. This will provide crucial insight for the subsequent measurement using real data and future studies involving two final states. The LHCb experiment has collected a large sample of Bs -> KS K+- pi-+ decays to date, which is expected to increase significantly in the next two years. This data sample will be used to perform the first decay-time-dependent Dalitz-plot analysis to the KS K+ pi- and KS K- pi+ final states simultaneously, and to determine the associated CP-violating observables. The results of the analysis will provide a novel method to test the SM. The theoretical interpretation of in terms of potential NP sources of CP violation benefits from U-spin relations with the companion Bd -> KS K+- pi-+ decay, which can be used to control hadronic uncertainties. Analyses of the Bd modes will require larger data samples, which are not included in the baseline plan of this project. However, this project will set the stage for these measurements, developing all necessary methodology for a systematically improvable precise test of the SM.

Mots clés : new physics beyond the standard model flavour physics cp violation beauty meson charmless decay dalitz plot analysis

Participants :
- Université de Warwick (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet EuUniv (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The demands of the Paris Agreement mean that we must shift toward a cleaner energy and transportation infrastructure. This requires new energy storage technologies. The rechargeable aqueous zinc battery (AZIB) offers a cheap, sustainable, safe, and high storage capacity solution suitable for complementing the intermittency of renewables, alongside commercial applications spanning transport to flexible ‘smart’ apparel. As a relatively nascent technology, AZIBs unfortunately suffer from fundamental materials chemistry issues, undergoing rapid performance decay over repeated charge/discharge cycles. I am an experienced researcher in eutectic electrolytes, a type of electrolyte with strong interactions between its constituent components, and I believe they can pose a solution to many of the failures that occur in AZIBs. However, understanding the complexity going on inside an operating battery is notoriously difficult, yet doing so is necessary to unlock the fundamental knowledge required for me to design the ideal electrolyte to combat AZIB capacity fade. Working with Dr Robertson at Warwick University, I will learn how to perform advanced insitu characterisation of AZIBs, across X-ray spectroscopy and transmission electron microscopy (TEM), and use them to diagnose these complex processes. This will allow me to design an optimal eutectic electrolyte for AZIBs, which I will then investigate for scale-up feasibility at Warwick’s battery pilot line. My research objectives: - Reveal the role of different eutectic electrolyte compositions on the AZB metal anode. - Diagnose why AZIB cathodes are more robust when cycled with certain eutectic electrolytes - Design a suitable eutectic electrolyte for a full-cell AZIB, taking into account industrial scale-up considerations. Supported by gaining technical training in operando electrochemical TEM and X-ray diffraction, in-situ X-ray absorption spectroscopy, and an introduction to pilot-line scale-up of new battery technology.

Mots clés : zinc batteries, aqueous zinc batteries, in situ characterization

Participants :
- Université de Warwick (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet OPNANOELECTRO (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Carbon dioxide (CO2) electrolysis is a promising route for converting greenhouse gases into value-added products. However, the industrial viability of CO2 electrolyzers requires significant advances in electrocatalyst design for cathode CO2 reduction reaction (CO2RR) and anode oxygen evolution reaction (OER). The major challenge lies in understanding the structure-performance relationship, which is complicated due to the unusual sensitivity of the reactivity and product selectivity to the surface structure and the change of active materials under operando conditions. The project advocates the development and innovative application of multi-microscopy, with state-of-the-art SPM as the core technology, to exclude how nanostructured heterogeneity and structural dynamics affect catalytic performance, ultimately accelerating the discovery of electrocatalysts. The research scope includes: i) identifying active sites over a heterogeneous catalyst on the nanoscale by scanning electrochemical probe microscopy (SEPM) and corelative microscopies; ii) tracking and interpreting physicochemical dynamics of active sites under reaction conditions by electrochemical atomic force microscopy (AFM) and correlative spectroelectrochemical characterization and density functional theory modeling; iii) correlating knowledge of heterogeneous and dymanics to global performance of CO2 electrolysis flow-cell via rational design of electromaterials. The proposed program combines the unique expertise of the Host group in SEPM with the Fellow's extensive knowledge in AFM, heterogeneous electrocatalysis and nanoscience to create new paradigms that will advance electrocatalysis and energy fields. The Host group's support will enable the Fellow to develop valuable skills and establish a robust academic network, enhancing her career prospects.

Mots clés : scanning probe microscopy nanoscience nanoscale electrochemical mapping electrified interfaces interfacial dynamics structure performance relationships electrocatalysis co2 electrolysis

Participants :
- Université de Warwick (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet RAGE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Affective gaming - or gameplay that is influenced by a player's emotional state - is a research domain at the intersection of HCI and affective computing; yet the field has stagnated over the years since its inception back in the early 1980s. In RAGE, I will revitalize the field of affective gaming by addressing foundational epistemic problems that are contributing to this stagnation. RAGE’s research objectives tackle explicating unclear and hidden assumptions and value sets in this space, and the practical tensions that exist in terms of implementation. I analyze the field through both a theoretical lens in the first year, and moving to a practical implementation of affective games in the second. In this project, I will transfer my knowledge in designing and creating affective games for the implementation aspects of RAGE while Prof. Elisa Mekler (ITU Copenhagen, Denmark) will support the theory aspects. With this fundamentally interdisciplinary project, I will collaborate with and connect many research groups and labs at ITU from different disciplines, including the Center for Digital Play, the Affective Interactions and Relations (AIR) lab, and the Interaction design (IxD) lab. Collaboration within this interdisciplinary team and broadening my research portfolio to include theoretical and critical research will allow me to shape a research vision and establish myself as a key researcher of affective gaming within the EU, in service of my eventual goal to lead my own research group within the EU.

Mots clés : affective gaming, emotion, hci, theory

Participants :
- IT University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €