Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet IMPASTO (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Statut du projet : CLOSED

The emerging climate services in Europe and globally under the WMO GFCS critically depend on the science and application of Earth System (ES) modeling and prediction. An important aspect of the modelling and prediction challenge for the services is characterization of prediction uncertainty. Quantitative information about inherent uncertainty in the prediction is vital for risk assessments and decision support across public service and industry sectors. Over the past decades significant investments were made through the EC FPs into establishing the ES ensemble modeling and prediction capabilities that incorporate representation of sources of intrinsic uncertainty in the modeling systems and provide quantification of their impacts on seasonal to decadal climate prediction. The identified stakeholder priorities for the H2020 and beyond are in advancing of these prediction capabilities at regional level with high resolution models. This project is intended to contribute to the science of high resolution regional seasonal climate ensemble modeling, addressing the need for understanding and quantification of the prediction uncertainty at sub-regional and local scales. The research will focus on characterization of stochastic uncertainty associated with physical parameterizations in the regional ES models. The project will integrate the established ensemble modeling methodology from the foundational work with the global systems with a new approach to representing the stochastic uncertainty of physical parameterizations by means of inverse stochastic modeling using process-level observations. A long standing tradition in expert regional climate modeling at the hosting institution will be joined with the Researcher’s expertise and experience in geophysical modeling and cross-disciplinary methodology of data assimilation. The Researcher will be trained in the regional climate modeling and will apply the expertise to build a new research capacity at the hosting institution.

Mots clés : ensemble prediction, weather and climate modeling, stochastic physics parameterizations, inverse modeling, estimation, data assimilation

Participants :
- University of Belgrade (Serbie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 140021.76 €
Projet EMUSIG (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The emotional power of music is a force we reckon with on a daily basis. Bubbly music in advertisements entices us to buy products. Tranquil music in medical waiting rooms evokes calm and diffuses anxiety. In spite of its extensive influence, there are still many open questions about how music impacts our emotions. One emotion in particular has been largely overlooked in music and emotion research: fear. The lack of research is surprising given the important role fear plays in society. Fear-based mental disorders are the most widespread, negatively impacting the lives of millions worldwide. Fear drives our daily behaviors and thus is used frequently to spread beliefs for political gain. Given its relevance, there are many benefits for deepening our understanding of fear. Music, a powerful emotional influencer, could be the ideal tool for furthering our knowledge of fear. This groundbreaking, interdisciplinary action will unlock the potential of music as a platform for fear research through the combined use of methods from cognitive neuroscience, behavioral psychology, and music theory. Specifically, my research objectives are to create a new multicultural database of scary music excerpts, catalogue cultural and biological musical fear signals, and synthesize the results of this research into a comprehensive report on musical fear signaling. My training in music theory and cognition methods and my expertise in film music make me the ideal person for this action. The interdisciplinary, state-of-the-art research environment at the Cognitive and Affective Neuroscience Laboratory at the University of Zurich is the perfect location for this work. At this pioneering lab in the field of vocal and music perception, I will be trained in cognitive neuroscience methods (fMRI & eye tracking), statistical and programming skills, and in communicating my interdisciplinary work, fostering my development as an independent music cognition scholar capable of leading my own laboratory.

Mots clés : music and emotion, vocal affective cues, film music, fear and the brain, fmri, eye tracking, topic theory

Participants :
- University of Zurich (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet HeLLo (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The energy refurbishment of heritage, field of the HeLLo proposal, is a priority of the EU policies to reduce fuel consumption. Historic buildings constitute a great amount of the EU existing stock, whose richness, coupled with a social and cultural value, especially in the Italian context, justifies the fellowship location. However, the lack of specific tools for the intervention on this kind of buildings and the scarcity of data about their energy state-of-the-art, make them mostly excluded from core strategic plans of the Member States, losing a great chance towards a net zero-energy future. OBJECTIVE OF THE PROPOSAL HeLLo aims at spreading awareness about the most common energy retrofit solutions and increase knowledge of their application in historic buildings, hoping to contribute in the EU refurbishments strategies issues related to the historic heritage. There are two specific objectives: to check the compatibility of technologies already certified and applied to new buildings on historic constructions and, to create a structured dissemination programme that opens the doors of laboratory life to the outside of the academic boundaries. HOW THE OBJECTIVE WILL BE ACHIEVED Results will be achieved through a twofold strategy:1) the creation of a true experimental laboratory in which to test such technologies and quantifying their real performance; 2) a project of ‘dissemination laboratories’ that offers an ‘experimental experience’ that makes known the world of investigation by the practice of the living lab. RELEVANCE TO THE WORK PROGRAMME The achievements of the research are directed to overcome the criticalities related to energy retrofit of historic buildings towards a deep enhancement of EU heritage performance, and to ensure that the EU reaches the objectives stated in the H2020 work programme. HeLLo is an important step in my career to fulfil the ambition to become an independent technology and energy expert and getting a tenure track position within EU.

Mots clés : historic buildings, energy refurbishment, experimental test, off site simulation, dissemination strategy, technological solutions, building materials, on site training, living lab

Participants :
- University of Ferrara (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 168277.2 €
Projet SpecIAnt (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The enormous amount of diversity that surrounds us raises one of the key questions in evolutionary biology: How do new species originate? Speciation depends on the evolution of reproductive isolation but, with few exceptions, the genes underlying reproductive isolation and their modes of action are unknown. The novelty of this project lies in testing if, in addition to mutations in genes, epigenetics and gene expression are mechanisms that contribute to the process of speciation. For these aims I will use wood ants and their hybrids combining large-scale data sets on genomes, gene expression and genome-wide methylation. These approaches will be complemented with protein modeling of candidate genes resulting in a multidisciplinary project. Further aims are to develop an outreach programme on evolution for high schools and in collaboration with the Finnish Environment Institute to investigate the role of hybrids in forest ecosystems. Together these objectives yield a project that has high scientific standing and societal importance.

Mots clés : speciation, hybridization, evolutionary genetics, comparative genomics, population genetics, hymenoptera, mound building wood ants, science communication

Participants :
- University of Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191325.6 €
Projet ULPIoT (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The era of the Internet of Things (IoT), in which every physical entity includes power-autonomous embedded electronics, capturing relevant information by sensors and interacting with objects and humans in a globally interconnected network, is bringing about new challenges in Integrated Circuit (IC) design. The performance of ICs in terms of integration density, power consumption and cost, in fact, is the only limiting factor to the feasibility and/or to the widespread diffusion of IoT-based solutions. Digital ICs in the most recent nanoscale CMOS technologies are keeping the pace of IoT requirements. On the contrary, the implementation of analog functions, which are however essential to acquire data from sensors, thus enabling the interactions of IoT nodes with the surrounding environment, is nowadays the real bottleneck and the most serious concern and limiting factor for the further development of IoT applications. In the foreseeable future, the planned device scaling and voltage reduction down to near threshold (e.g. 0.4-0.5V) makes the design of analog circuits extremely hard, in view of the degradation of signal-to-noise ratio, matching and linearity. Despite of device shrinking, traditional low-voltages analog circuits do not really scale down in size, and occupy a more and more relevant percentage (i.e., cost) of the die area. In this scenario, the proposed research activity is intended to substantially enhance the scalability of analog blocks with technology and voltage by re-thinking analog functions in ICs in digital terms. In a new cross-domain approach, design and testing methodologies from the digital world will be extended and frontier design concepts like near-threshold operation further exploited. The effectiveness of the proposed approach will be verified and validated on IC demonstrators and with reference to a full SoC for wearable electronics applications in the development of novel IoT solutions.

Mots clés : integrated circuit  ic  design, ultra low power, internet of things  iot, digital ics, ics interfaces, device scaling and voltage reduction

Participants :
- National University of Singapore (Singapour) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Polytechnic University of Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 247728.6 €
Projet GLUCOTANYCYTES (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The escalating epidemic of obesity, type-2 diabetes and metabolic syndrome represents one of the most pressing and costly biomedical challenges confronting modern society. The impaired action of peripheral hormones on brain circuits controlling feeding and energy homeostasis, also known as "central hormone resistance", is increasingly recognized as playing a role in the pathophysiology of these disorders. The host laboratory has raised the groundbreaking notion that tanycytes, a specific type of hypothalamic glial cells, act as "gatekeepers" that regulate the access of blood-borne signals to the hypothalamus, and in particular, their vesicular transport into the cerebrospinal fluid, from where they enters other metabolic-hormone-sensitive regions. The overall objective of this proposal is to further develop this highly original angle by using state-of-the-art approaches to i) gain new insights into the molecular mechanisms underlying structural changes in the tanycytic barrier in response to fluctuating concentrations of circulating glucose, and determine how these processes are altered in animal models with acquired type-2 diabetes, and ii) explore the possibility that tanycytes are involved in the shuttling of circulating glucose into the cerebrospinal fluid (CSF) and that the tanycytic expression of the NMDA receptor plays a role in this process. This research promises to shed new light on the molecular mechanisms used by the hypothalamus to integrate key peripheral signals and coordinate energy homeostasis. The results will pave the way for the development of new treatment strategies to overcome hormone resistance in human obesity and associated metabolic syndromes.

Mots clés : type 2 diabetes, obesity, glucose, tanycytes, blood brain barrier, plasticity, nmda, cerebrospinal fluid

Participants :
- Université de Lille (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173076.0 €
Projet TUNEMODE (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The evolution of the bandwidth demand in optical fiber communication system in the Europe region keeps increasing year after year. As for now, most of these demands are supported by the WDM system of optical communication network. It is forecasted that this increasing bandwidth demand could not be supported any more data traffics in the future due to the consumption growth of new applications. In this regards, a new system for solving this issue is becoming all the necessary. An alternative which is forecasted to be able to fulfill this demand is Mode Division Multiplexing (MDM). MDM basically is based on a concept developed for increasing the optical data transmission capacity within the optical fiber itself. Thus, this project will be carried out to investigate the mode tuning of random fiber laser for the application in MDM system. The main objective of this project is to generate a laser with various modes which can be tuned by using few mode fiber and will be using random fiber laser. The purpose of using random fiber laser is because the conventional rare earth based fiber laser such as Erbium and Ytterbium are not optimized for lasing at higher order mode than the fundamental mode LP01. Investigation on mode tunability will be carried out using micro fiber technology and also fiber Bragg grating technology whereby the combination of these two technologies will be functioning as the tunable and filtering element. Also, in this project, new ideas and concepts will be developed whereby the generation of a laser with various modes will probably generate new concepts and findings, not only for MDM system, but also for the device to support this application in the future. In this regards, this research is very significant, in conjunction with the growth of the bandwidth demand in the Europe region as well as in the world.


Participants :
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet mAMBo (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The evolutionary expansion of the neocortex in the primate lineage, and particularly in humans, underpins our higher cognitive abilities. Neural stem and progenitor cells (NPCs) show increased duration of proliferative phases in humans when compared to other mammals and particularly mice. However, the mechanisms responsible for these evolutionary differences in progenitor properties are poorly understood. In this study, I aim to explore the function of the ASCL1 and MYCN proteins in human NPCs. These two factors are crucial to promote proliferation in different NPC populations of the mouse forebrain, but their function in promoting proliferation of human NPCs, where they are broadly expressed, is not known. I will evaluate the spatio-temporal expression of ASCL1 and MYCN throughout human neocortical development and I will assess their cellular functions during NPC expansion using loss-of-function experiments. Finally, I will determine if ASCL1 and/or MYCN regulation have diverged between mouse and human to allow for the extended proliferative capacity of human NPCs. For this project, I will use human embryonic and fetal brain tissue and pluripotent stem cell-derived 2D neuronal and 3D spheroid cultures as in vitro models that recapitulate many aspects of human brain development. Together, this work will provide insights into the mechanisms regulating the duration of NPC expansion, a crucial parameter that underscores key differences in brain size between species, and will help to better assess the pathological mechanisms at the origin of neurodevelopmental diseases.

Mots clés : neural stem cells, proliferation, human brain development, brain organoids, ascl1, mycn

Participants :
- The Francis Crick Institute (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 212933.76 €
Projet RaDTho (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The existence of a low-lying nuclear isomer of thorium-229 at 8.28 eV was suggested several decades ago but was only recently identified via the observation of its decay signal. The low energy and an estimated relative decay width of around 10^{-19} open new possibilities for the development of a nuclear frequency standard-a nuclear clock, which can outperform the existing atomic clocks. This will have far-reaching consequences, such as in metrology, dark matter research, geodesy and time variation of fundamental constants. However, the isomer's properties are unknown or known with insufficient accuracy to exploit its far-reaching opportunities. This proposal aims to determine the properties of the isomer using two complementary techniques. 1. The isomer is populated using a novel mechanism via the beta-decay of actinium-229 implanted in a suitable crystal at the ISOLDE-CERN facility. VUV spectrometry of the implanted crystal will allow measurement of the isomer's excitation energy with a precision of < 0.1 nm as well as its radiative-decay half-life. This production scheme increases the sensitivity by at least a factor of five and allows for improved control of experimental conditions and a reduced background signal. 2. Magnetic dipole and electric quadrupole moment as well as the nuclear charge radii of the singly charged ground state and isomer of thorium-229, produced via alpha-decay of uranium-233, will be measured using the in-gas-jet laser ionization and spectroscopy technique at KU Leuven. This technique allows the necessary efficiency, sensitivity and spectral resolution to measure the hyperfine structure of the singly charged thorium-229 ground state and isomer.

Mots clés : nuclear clock, isomer, hyperfine structure, laser spectroscopy

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166320.0 €
Projet STAR-AGESS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The experience of religious ritual played a key role in ancient societies, as it negotiated ideas of cosmology and identity. By addressing the cosmos, participation in rituals forged ideas of belonging, which increased social cohesion and negotiated power permeating all aspects of society. Despite its importance, ancient Greek ritual experience has only been studied from static temporal and spatial viewpoints. Religious processions, open-air ritual re-enactments and performances operated in three-dimensional spaces, linked to the movement of the participants and affected by the play of light, shadows and celestial bodies visible at the time when they were held. These elements were instrumental in shaping the experience and memories of the attendants, influencing the society as a whole. STAR-AGESS will provide a new approach to the study of ancient Greek ritual practice by recreating immersive environments that incorporate ancient sky and astronomical simulations, horizons, detailed topography and architectural 3D models of the sanctuaries at Sounion, Aegina and Perachora. These three key case studies were selected as they have enough extant remains and written information to allow meaningful reconstructions in an extra-urban environment. They will be virtually explored at specific times of the day/night and year to gain insights into religious practice, ritual timing, astronomical connections, and into how they might have shaped experience and social memory through specific socio-mythical associations. To do so, the Experienced Researcher (ER) will reconstruct the total environment with the aid of targeted hands-on-research training, using advanced 3D techniques, landscape analysis and current theoretical approaches on the cognitive formation of space and experience in ritual performance. These methods will enhance the ER’s profile with cutting-edge techniques that will situate her at the forefront of research and boost her career.

Mots clés : ritual, sanctuaries, performance, archaeoastronomy, classical, archaeology, 3d reconstruction, topography, landscape, perception, cognitive analysis, virtual reality

Participants :
- Institut Català d'Arqueologia Clàssica (Espagne) — Coordinator, beneficiary, Recherche, subvention : 120699.36 €