Projet EuroNeurotrophin (Horizon 2020, appel à projets 2017)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : CLOSED

Neurodegenerative diseases (ND) like AD, PD, MS and ALS/MND are on the rise in developed societies worldwide. Currently, there exists no cure for any ND, and most of the available drugs fail to tackle ND pathogenesis. Preclinical studies point to the therapeutic potential of neurotrophins, which have been shown to control a number of aspects of survival, development and function of neurons. However, the poor pharmacokinetic properties of neurotrophins render their use as drugs prohibitive. The key idea behind this project is to address this limitation by developing novel small molecule, neurotrophin mimetics with favourable profiles of stability, tissue penetration and targeted biological actions. We are motivated by seminal (patented) results of beneficiaries NHRF and FORTH, who recently demonstrated promising effects of small neurotrophin mimetics in neuroprotection and neurogenesis. EuroNeurotrophin will be the first European consortium to study small molecule neurotrophin mimetics in depth, use them as molecular probes to interrogate neurotrophins, and emphasise their clinical translation. This approach requires highly skilled researchers that have a deep understanding of neurotrophins, comprehend all steps of drug discovery and development for ND, and possess the necessary skills to translate results into novel therapies. The network has been designed to address the need for the development of new ND treatments through the collaborative training of 14 early-stage researchers. It builds on previous successful collaborations enriched with key specialists, and consists of 12 leading European research groups and 5 private companies of complementary expertise covering all steps of drug discovery and development. Collectively we will (a) conduct a unique training programme that could not be achieved by doctoral training within a single academic institution and (b) accelerate the translation of identified drug candidate molecules into the market.

Mots clés : neurotrophins mimetics, marine microbial metabolites, in vitro screening, zebrafish, pharmacology

Participants :
- National Hellenic Research Foundation (Grèce) — Coordinator, beneficiary, Recherche, subvention : 484773.84 €
- Peakdel molecular limited (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Crete (Grèce) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Foundation for Research and Technology Hellas (Grèce) — Partner, beneficiary, Recherche, subvention : 484773.84 €
- University of Sheffield (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 450697.26 €
- Ventac a/s (Danemark) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Heidelberg University (Allemagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Innoprot (Spain) (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- National and Kapodistrian University of Athens (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 242386.92 €
- Novartis (Switzerland) (Grèce) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Vrije Universiteit Amsterdam (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 418530.07 €
- AvantiCell Science (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 194565.79 €
- Heidelberg Institute for Theoretical Studies (Allemagne) — Partner, beneficiary, Recherche, subvention : 498432.96 €
- TU Dresden (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 249216.48 €
- University of Siena (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- Accelopment (Switzerland) (Suisse) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Caen Normandie (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262875.6 €