Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MisBav (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

MisBav intends to offer new insight into the connections and networks that made up medieval Western Europe, deploying a neglected source, the missal. Missals were found in every city, monastery and parish, because they were needed to celebrate the Mass, a ritual which played a crucial role in the relationships that made up medieval society. Each mass has a distinctive subject, which can vary hugely, and new masses were continually composed in the Middle Ages, to respond to historical events, but also to celebrate and solidify bonds. These new masses represent an entirely neglected creative output of the period. The manuscripts of missals themselves were also constantly updated and exchanged. This is not therefore the sterile tradition that it might appear, but rather a vibrant product of collaboration across cultural and political boundaries. But these sources remain largely inaccessible, and are rarely used outside of disciplinary siloes. This project will bring these sources to innovative use, deploying them to demonstrate relations of medieval institutions with each other. The specific subject is the missals made in Bavaria, a cultural crossroads of medieval Europe. Strongly culturally linked to Italy from its time as an independent state, Bavaria was brought into the Carolingian Empire and became a key participant of cultural and religious movements that spanned into France. It was also the source for the Christianisation of the kingdoms of Central and Eastern Europe. All of these left indelible marks on Bavaria's missals. The project thus aims to reconstruct the specific traits of missals made in Bavaria between 900 and 1200, and use these to track and demonstrate the cultural and intellectual exchanges that made this area part of a broader medieval Europe. It will develop new digital tools to enable research into missals more broadly. It will show how missals are a crucial witness to the dynamism and connectedness of medieval culture.

Mots clés : manuscripts, liturgy, ritual, palaeography, digital humanities

Participants :
- Institute of Art (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 163166.16 €
Projet Nano-LYTAC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Cancer remains a tough challenge, largely because 80% of cancer-driving proteins are considered “undruggable” meaning impossible to target with conventional therapies. Nano-LYTAC project brings together experts in nanomedicine, pharmaceutical technology, and nanotoxicology to answer the burning question: Does complete cancer eradication still remain as an elusive dream? By combining 2 cutting-edge technologies: “Smart Nanotechnology” and “Targeted Protein Degraders (TPDs)”, this project fulfills the goals of Europe’s Beating Cancer Plan by tackling these undruggable proteins. TPDs were created using Nobel Prize-winning bioorthogonal chemistry. Among these, LYTACs (Lysosomal Targeting Chimeras), with their ability to transport intracellular/extracellular cancer-driving protein for selective degradation in the lysosomes, abrogate the cancer pathology. However, despite their promise, LYTACs haven’t made it to clinical use yet, owing to challenges like limited molecule diversity, poor tumor penetration, low bioavailability, and metabolic instability. To transform LYTACs into clinically viable cancer therapies, and to overcome the aforementioned drawbacks, this project will use novel nanotechnological approach to enable enhanced tumor penetration, selectivity, protection, and controlled released of the LYTACs in tumor microenvironment. Moreover, for the first time, I will design new LYTAC molecules specifically targeting folate receptors that are overexpressed on many types of cancers (e.g.: breast cancers, lung cancer, ovarian cancers). At CATRIN, under the guidance of Prof. Kateřina Poláková, an expert in nanomedicine and their subcellular trafficking, and nanotoxicology, I will develop "Smart Nano-LYTACs" with the preclinical proof of their potential. This multidisciplinary project will also enhance my skills in nanotherapeutics and cancer biology, helping me to work towards my long-term goal of establishing my own research group focused on advanced cancer therapies.

Mots clés : anticancer therapy, nanomedicine, bioconjugation chemistry, targeted protein degradation

Participants :
- Université Charles de Prague (Rép. Tchèque) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Palacký (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 207758.16 €
Projet FOUFCCURL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The Union of Florence (1439) has been often depicted as a resounding failure of an ambitious undertaking. However, this portrayal does not hold true in Lithuania and Ruthenia, where it acted as a catalyst for religious dialogue and integration, with the Franciscan Observants as its primary supporters. FOUFCCURL will pursue a comprehensive investigation into the role of the Observant Franciscans, known in Poland and Lithuania as ‘Bernardyni’, in utilising the achievements of the Union of Florence as a distinct and practical strategy for Catholicising Lithuania and Ruthenia. FOUFCCURL aims to uncover how the Observants employed the Union of Florence during the latter half of the fifteenth century, drawing on largely understudied sources beyond the important but over-relied Chronicle of Jan of Komorowo. The project will examine papal bulls, the Cismontane Observant Register, the papal ‘Instructio pro Mariano de Jeziorko’, and other lesser-known Franciscan chronicles. Another goal of the research is to bridge the historiographical gap between Western Medieval Studies and the regional historiographies of East Central Europe concerning the Franciscan Observants. To achieve this FOUFCCURL will synthesise the advanced methodologies and insights developed by Western medievalists with the unique historical contexts and sources of Ruthenia and Lithuania. Thus, the project will help illuminate broader patterns of religious and social integration in Europe. FOUFCCURL will also analyse the spatial distribution of Observant foundations in Lithuania and Ruthenia to identify discernible trends in their foundation patterns and create professional maps illustrating their expansion. FOUFCCURL seeks not only to offer a new understanding of the Union’s ‘second life’ in East Central Europe but also to contribute to wider historiographical debates on social and political integration across religious boundaries, enriching our understanding of cross-faith dynamics in the region and beyond.

Mots clés : franciscan order, observant franciscans, the union of florence, religious history, east central europe, grand duchy of lithuania, medieval rus

Participants :
- Université catholique Jean-Paul II de Lublin (Pologne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Palacký (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191918.16 €
Projet ActBio (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Vibrational spectroscopy has evolved into many branches and proved to be increasingly efficient in studies of biomolecules and their functions in living organisms. To further increase its potential, in this project we will develop and apply user-friendly tools (ActBio) for simulation of the spectra beyond the harmonic level. We will focus on vibrational optical activity (VOA), because this spectroscopy reveals unique information about chiral molecules. Thanks to the recent instrumental developments in the hosting institute, nonfundamental bands can be captured with a high precision, and the simulation methods for these complex bands will help us to understand many molecular properties. The project tightly combines both experiment and the theory, based world-recognized expertise in this field of the hosting institute and secondment laboratories. I will receive experimental training, further develop the extended perturbational approach to deal with the challenges of complicated biomolecular systems, such as large amplitude motions and solvent effects in polar and flexible molecules. Melanocyte-inhibiting factor is selected as a testing system for the developed computational models and protocols. In summary, ActBio will deliver accurate theoretical basis for spectroscopic biomolecular studies and will provide us with knowledge of molecular behavior needed for applications in chemistry, medicine, and biology.

Mots clés : vibrational optical activity, anharmonicity, vibrational spectroscopy, chirality, molecular modeling, vibrational circular dichroism, raman optical activity, vibrational perturbation theory

Participants :
- Institute of Organic Chemistry and Biochemistry (Rép. Tchèque) — Coordinator, beneficiary, Recherche, subvention : 166278.72 €
- Université de Tromsø (Norvège) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université Palacký (Rép. Tchèque) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MUCOFISH (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The fastest-growing food production sector, aquaculture, faces important challenges because of infectious agents. Vaccination is the most effective way to prevent and potentially eradicate such diseases, but to date, most commercial vaccines are administered by injection methods, which for fish, imply many disadvantages. On the other hand, mucosal vaccines (directly administered to mucosal tissues) offer a promising and cost-effective alternative. In my MSCA project, I aspire to bring the field of mucosal immunology to the next level by applying my expertise in immune anatomy and working in the renowned laboratory of Prof. Carolina Tafalla who specializes in characterizing teleost B cells. Through this collaboration, I will uncover the cellular mechanisms and interactions of IgM and IgD B cells at fish mucosal sites, such as gills, skin, and intestines. In these tissues, plasma-like B cells secreting IgM coexist with IgD+IgM- B cells, cells that have lost surface IgM through an unclear recombination event. These cells secrete IgD, suggesting an important but undefined role for IgD at specific mucosal surfaces. At INIA, I will be trained in flow cytometry and single-cell transcriptomics. I will complement these techniques with my knowledge of immune anatomy to comprehensively unveil the role of these mucosal plasma-like cells upon immunization in rainbow trout. This project will innovatively expedite mucosal immunology research and underline my ambitions to become an independent scientist. I will further sharpen my scientist profile through CSIC’s mentoring programs for young researchers, which will enhance my skills in formulating and managing large-scale projects. I will also supervise students, keeping me engaged in the academic sector. The proposal addresses pressing scientific questions by integrating the expertise and network of both the host and me while shaping my path to becoming a senior scientist.

Mots clés : mucosal vaccines, immunization, immunoglobulins, teleost b cells

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €
Projet PASS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

It is commonly known that Portland cement production causes tremendous environmental impacts. In this context, sustainable binders are desired. Alkali-activated materials (AAMs) have attracted increasing attention due to their lower embodied energy and 25-60% less CO2 emission. The most widely used precursors to synthesise AAMs are ground granulated blast furnace slag (GGBFS), fly ash and metakaolin. Among these, alkali-activated GGBFS (AAS) is the dominant class of AAMs in large-scale production. However, the availability of GGBFS is becoming limited due to the policy changes related to green transition of the iron and steel industry, which consequently impedes the commercial scale production and use of AAS. To deal with this issue, researchers are searching for alternative metallurgical slags, such as ferronickel slag, copper slag, lead-zinc slag and electrolytic manganese residue. Although many efforts have been made, the current utilization of these metallurgical slags as precursors is still restricted. One of the biggest obstacles is the considerable amounts of heavy metals (HMs) in these metallurgical slags. Effective immobilization of HMs within AAS has become a critical issue for utilizing these metallurgical slags. Against this background, we aim to determine the performance of AAS binder in immobilizing HMs under in-service conditions. The effects of slag chemistry and alkaline activator on solidification as well as ions leaching, cracking and redox condition in slag on stabilization of HMs in AAS will be elucidated. Moreover, a novel reactive-transport model considering the binder chemistry and shrinkage-induced cracking will be established for the first time to predict solidification/stabilization of HMs in AAS. The results of this project will provide a solid foundation for assessing the performance of AAS in immobilizing HMs, which is essential for the sustainable development of AAS and efficient treatment of hazardous wastes by using AAS binder.

Mots clés : low carbon concrete, sustainable development, alkali activated slag, heavy metals, immobilization, reactive transport model, leaching, in service conditions, solidification stabilization mechanism

Participants :
- Institut Paul Scherrer (Suisse) — Partner, associated partner, Recherche, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 209914.56 €
Projet MIR2RKN (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Root knot nematodes (RKNs) represent a major problem for global food security. Current control strategies of RKN have critical limitations. Beneficial root-associated microbes, like rhizobacteria, can enhance the plant immune systems, boosting resistance to a broad spectrum of attackers, including RKNs. This phenomenon, known as Microbe-Induced plant Resistance (MIR), has emerged as a promising biotechnological tool for a sustainable RKN control. However, there are still important challenges in the implementation of MIR-based products in RKN protection programs. We are just starting to uncover molecular mechanisms underlying MIR’s effectiveness to RKN, which have complex, long-term relationship with plants, including well-differentiated infection stages. The main aim of MIR2RNK is to contribute to elucidating molecular mechanisms that regulate MIR functioning to RKN in tomato. MIR2RKN will use a multidisciplinary approach combining multi-omics high-throughput techniques, computational biology, functional genomics, and mesocosm experiments to achieve three main objectives: (1) To evaluate the impact of rhizobacteria on tomato resistance to RKN throughout the infection cycle, and validate the economic viability of these findings under close-to-real field conditions; (2) To uncover key molecular traits of the tomato plant immune system that regulate rhizobacteria-MIR to RKNs across the infection cycle, and (3) To decipher the specific role of tomato polyamine metabolism in rhizobacteria-MIR to RKNs throughout the RKN’s infection cycle. MIR2RKN will enhance our understanding of how MIR is regulated during the dynamic infection cycle of RKNs. This knowledge on how MIR functions, will contribute to developing sustainable crop protection strategies against RKNs. Moreover, MIR2RKN will strongly benefit the applicant, as he will gain independence in research, wider visibility, and will be trained on fundamental skills for proceeding in the next step of his scientific path.

Mots clés : beneficial soil microbes, induced systemic resistance, root knot nematodes, plant defense mechanisms, transcriptomics, system biology, molecular signaling, phytohormones, secondary metabolites

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 209914.56 €
Projet SIRT7-LC (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Lung cancer is the second cause of death due to malignancy and diagnosed patients rarely survive beyond two years. Thus, unveiling the molecular mechanisms underlying lung tumorigenesis is imperative for development of novel therapeutic approaches. The nucleolar protein nucleophosmin (NPM) plays critical roles in cancer progression and is often deregulated in human malignancies. NPM employs distinct mechanisms to control cancer cells growth including regulation of the proto-oncogene c-Myc, a transcription factor often aberrantly activated in lung cancer. Recent studies highlighted the fundamental impact of post-translational modifications in controlling NPM functions. NPM is a deacetylation target of Sirtuin 7 (SIRT7), a member of a class of NAD+ dependent histone/protein deacetylases collectively known as sirtuins. Deacetylation of NPM by SIRT7 is fundamental to control NPM subcellular localization and stimulate NPM-mediated cellular stress responses. SIRT7 also acts as a potent oncogene in different malignancies although through still poorly characterized mechanisms. Thus, SIRT7-LC aims to characterize the impact of the SIRT7-NPM axis on regulation of c-Myc pro-oncogenic activities and its impact on lung cancer cells proliferation in vitro and in vivo, as well as possible aberrant activation of this pathway in human lung cancers and its correlation with prognosis. Thus, SIRT7-LC may lead to identification of novel molecular mechanisms sustaining lung cancer growth that could be targeted for therapeutic interventions. Dr. Alejandro Vaquero, a world-leading expert in the sirtuins field, will supervise this project. His competence in the field together with my expertise in characterization of mouse models of diseases will undoubtedly ensure successful realization of the proposed project, expanding my scientific knowledge, increasing my visibility as scientist and contributing to my development as a fully independent investigator.

Mots clés : sirtuins, sirt7, nucleophosmin npm , deacetylation, proto oncogene c myc, lung cancer

Participants :
- Fundación Josep Carreras Contra la Leucemia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet BIGHEATH (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The Strait of Gibraltar is a unique hotspot of plant biodiversity within the Mediterranean basin, considered as both a glacial refugium and a relatively permeable biogeographical barrier for plant biodiversity, due to its geological, edaphic and climatic singularities. At both sides of this strait, two heathland habitats of high conservation value and shared edaphic features (acid, infertile and sandy soils) deserve attention: Mediterranean dry heat (herriza) and temperate Atlantic wet heath, whose floras present a peculiar population genetic structure pointing to eco-evolutionary processes such as successful colonisations across the Strait of Gibraltar and isolation by ecogeographic barriers as main drivers in shaping heathland plant biodiversity. Nevertheless, the knowledge about this is still limited. In the present project, a multidisciplinary approach integrating genomics, phylogeography, phylogenomics, demographic inference and community ecology is proposed to contribute to a proper understanding of the role of the Strait of Gibraltar as biogeographical bridge/barrier for both heathland habitats, although particularly relevant for the forgotten but threatened wet heath flora. Likewise, the proposed project will enable to detect key biodiversity areas (probable glacial refugia) and the potential response of heathland plant biodiversity to climate change, essential information for its effective management and conservation.

Mots clés : phylogeography, evolutionary history, mediterranean plants, strait of gibraltar, climate change

Participants :
- Université de Cadix (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
- Conseil supérieur de la recherche scientifique (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet ArCeph (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Climate change is impacting global ecosystems, especially in the polar areas of the Earth. Countering climate change effects is stated as one of the key goals of both global development, in the 2030 Agenda for Sustainable Development, and of regional development, e.g. EU strategy of managing the Arctic. Cephalopoda (Phylum Mollusca) are pivotal components in marine food webs and have life history and physiological characteristics that make them potential winners of climate change. This group, due to their ecology and biology features, such as high abundance coupled with low taxonomic diversity, high degree of opportunism, ecological adaptability, single reproductive cycle and typically a short lifespan, cab ve used to assess and predict climate change-induced shifts of Arctic ecosystems. Thus, the main objective of the Action is to assess biodiversity, life histories and ecological role of cephalopods in the Arctic and their ontogenetic and temporary changes using both well-established and innovative methodologies, in the climate change context. The project addresses this matter via 3 scientific work packages that focus on the following research hypotheses: Hypothesis 1) diversity and distribution of current Arctic cephalopod populations shifts due to climate changes; Hypothesis 2) environmental conditions experienced during the life of individual cephalopods can be documented and used to assess the climate change impact on life histories, where comparing historical with new specimens will highlight climate change impact; and Hypothesis 3) the role of cephalopods in the Arctic food web is even more pivotal then we currently understand, and this would be tested with innovative food web modelling methods. The results achieved will increase the quality of ecological monitoring in the Arctic, leading to more rational management of the Arctic marine ecosystems in order to possibly counter climate change impact.

Mots clés : stable isotope analysis, environmantal dna, food web modelling

Participants :
- GEOMAR Helmholtz Centre for Ocean Research Kiel (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €