Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SmartSorp (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The aim of this project is to develop a novel ceramic hollow fiber adsorption system for high throughput, energy efficient separation and purification of gases/ vapours. Current adsorption technologies are grossly energy inefficient due to waste heat generation and long regeneration times. Therefore, it is important to develop new energy efficient, smart functional materials in order to meet society’s future energy demands. Functional hollow fibers with smart characteristics (such as self-regulated heating and regeneration of the adsorbent bed) have the potential to meet these challenges, and compact systems could be formed that also exhibit low pressure drop, no adsorbent bed settling and channelling, and have a low thermal mass for rapid regeneration of the adsorbent layer. The novel hollow fiber will consist of a thin film zeolite inner layer for adsorption of target species, while the outer layer is formed from a perovskite-type Lanthanum doped BaTiO3 ceramic with positive temperature coefficient of resistance (PTCR) characteristics. The PTCR layer provides inherent temperature control, imparting self-regulating and self-limited Ohmic (Joule) heating with thermal energy directed onto the inner adsorbent layer in order to regenerate the system for the next process cycle. This is a highly multidisciplinary project encompassing the formation of electro-ceramic hollow fibers from wet spinning techniques, zeolite deposition chemistry, and industrial engineering. The MSC-IF researcher will work within the Swiss Federal Institute for Materials Research (EMPA) in the High Performance Ceramics Group, where he will develop expertise in ceramic processing and extrusion. A prototype ceramic hollow fiber, gas purification system will be developed and benchmarked against conventional packed-bed technology, during a secondment phase to NanoPurification Solutions Ltd (UK), a manufacturer of industrial gas separation technology.

Mots clés : ceramic hollow fibers, smart materials, gas separation and purification, energy efficiency

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet ModSingLDT (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Statut du projet : CLOSED

The aim of this project is to investigate enumerative invariants of the Hilbert schemes parametrizing zero-dimensional subschemes of some basic classes of surface singularities as well as of its higher rank analogues, and find connections between these enumerative invariants and the Chern-Simons theories on the links of the singularities. This question will open brand new relations between algebraic and topological invariants of these singularities. The main tool to approach the problem will be to develop representations of vertex algebras on the cohomologies or derived categories of these moduli spaces conjecturally giving rise to analogues of the Nekrasov parition function on the singularities. Then we will use recent new developements about a specific motivic measure with values in the Grothendieck ring of geometric dg categories to prove some simplification of the aimed correspondence. In the end we will raise these simplified results to the general level. This project will allow the researcher to broaden his area of expertise as well as to develop new directions in his research lines. He will complement his knowledge in low-dimensional topology at one of the most prestigious research institutes and under the guidance of one of the worldwide leaders in this field.

Mots clés : hilbert scheme of points, normal surface singularities, vertex algebras, nekrasov partition function, chern simons theory

Participants :
- Hungarian Academy of Sciences (Hongrie) — Coordinator, beneficiary, Recherche, subvention : 151850.88 €
Projet CO-PHY-MED (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The aim of this project is to investigate the mechanisms and processes that drive divergence and speciation, and shape the biogeographical history of organisms. Using the Mediterranean, a natural laboratory for phylogeographic investigations, we propose a novel large-scale approach in comparative phylogeography: a time-saving and cost-efficient one that includes multiple lines of evidence in a single analysis and exploits modern Next Generation Sequencing methods and advances in phylogenomics. We will (1) collect genomic data for co-distributed species of an entire vertebrate order (squamate reptiles) applying sequence-capture protocols, (2) reconstruct a time-calibrated, fully resolved phylogenetic tree merging between- and within-species relations, (3) compare biogeographical and speciation patterns and (4) identify the major barriers that influenced the formation and evolution of biodiversity. Tackling this innovative and challenging project and hosted in institutions of international reputation by leading experts in their field, will contribute to his professional academic development and put him at the forefront of his field. The applicant is an early-career promising scientist and the participating institutes and research-groups have the qualifications and complementarity, regarding infrastructure, research experience, capacity to manage grants and train researchers, for the successful outcome of the research and training aspects of the project. The approaches and results of the project will become a part of the state-of-the-art of future studies and promote EU excellence in evolutionary biology and phylogenomics, likely to be in great demand in the near future. Results will be announced in prestigious international conferences and published in high ranked journals, primary data will be submitted to freely accessible repositories, while outreach activities will communicate the proposed research to the non-specialist public.

Mots clés : phylogeography, biogeography, evolution, speciation, diversification, phylogeny, phylogenetics, phylogenomics, next generation sequencing, sequence capture

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 239191.2 €
- University of Washington (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet DIGITAL ALFIERI (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of this project is to provide a dynamic digital edition of the manuscript Alfieri 13 (Biblioteca Medicea Laurenziana of Florence), in order to provide new perspectives on at least three fields: digital humanities, textual criticism, and 18th century literature. Alfieri 13 is a miscellaneous scribbling-book (232 pages) which is of a capital importance for the understanding of the evolution of Alfieri's thinking: in fact, it is a crossroad of several literary projects of Vittorio Alfieri (Asti 1749 – Florence 1803, one of the most important European writers of the 18th century). The digital output (allowing to link and cross-referring information in a non-sequential way) is the best way to highlight how the physical (static) conformation of the object (the manuscript) portrays the intellectual (dynamic) evolution of an individuality (the writer). The applicant will take the innovative approach of combining two concurrent (but complementary) perspectives on the study of manuscripts: filologia d'autore and critique génétique. Those approaches are now getting closer thanks to the recent establishment of an Italian research team at the hosting laboratory, the CNRS-ITEM (Institut des Textes & Manuscrits Modernes). This research team, Manuscrits Italiens du 18e siècle (Italian Manuscripts of the 18th century) is leaded by Christian Del Vento (supervisor for this project) and it will focus on methodological aspects and on controversial case studies, among which the manuscript Alfieri 13. The proposed digital edition of Alfieri 13, will be of a fundamental relevance for various fields, and especially: 1) Digital Humanities: it will provide digital textual criticism with an effective model, exploitable for other manuscripts and authors; 2) methodology: it will serve as a bridge between filologia d'autore and critique génétique; 3) literature and culture of the 18th: it will lay the foundations for a reliable edition of Alfieri's Vita and Rime.

Mots clés : textual criticism, critique g n tique, filologia d autore, digital humanities, autobiography, 18th century, italian literature, vittorio alfieri, manuscript, vita, rime

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 173076.0 €
Projet WorldlyMatter (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of this project is to re-evaluate established narratives of Conceptual Art in North America and Western Europe and their global context. It will examine the importance of materiality and subject matter – or “worldly matters”, to borrow Conceptual artist Douglas Huebler’s term – for Conceptual Art in the 1960s and early 1970s. Engaging with theories of conservation as well as the most recent discourses around materiality, the project combines a genuinely art historical objective, oriented towards the reconstruction of historical contexts, with broader theoretical perspectives. By studying artistic practices in-depth and reconstructing historical debates, it will make an important contribution to the history of Conceptual Art, and hence the immediate prehistory and preconditions of today’s cultural production. The project will enable the researcher to qualify for tenured positions in modern and contemporary art by building on his already extensive qualifications and record of research on nineteenth- and twentieth-century art. The fellowship will enhance his international experience from former fellowships at prestigious institutions in the United States and in France by providing another national context and a different type of organisation. The collaboration with a highly renowned supervisor at a top-ranked institution that attracts a vibrant international research community will offer the researcher the ideal context to attain his research objectives, broaden his expertise, extend the reach of his network, and diversify his skills through specialised training programmes. With his focus on the neglected material aspects of Conceptual Art, he will contribute to the host institution’s commitment to object-based research and teaching. Based on strategies developed in his personal career development plan, the researcher will disseminate his findings to target audiences and contribute broader understanding to society at large.

Mots clés : conceptual art, conceptualism, contemporary art, materiality, materials in art, photography

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Autres, subvention : 195454.8 €
Projet RandPol (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

The aim of this project is to study the zeros of random polynomials. Random polynomials appeared in the 1930's with the pioneering works of Bloch, Polya and Kac. The study of random polynomials gained a strong interest of the physicists since the 1990's due to their connexion with interaction particle systems such as electron gases (also called Coulomb gases). Random polynomials were first considered as a toy model for more complicated systems, but in the 2000's they appeared to exactly describe the behavior of certain Bose Gases. We want to understand the behavior of random polynomials at the macroscopic and microscopic scale. At the macroscopic scale, several questions naturally arise: Where can we locate the zeros? Are there isolated zeros far away from the rest of them? Can we describe the behavior of those isolated zeros? Very recent breakthrough (2019) were made in both localisation and isolated zeros for specific models of random pomynomials with some symmetry constraints. Our goal is to obtain general results on these questions. We plan to develop new ideas to tackle these questions, without relying on the symmetry structure. At the microscopic scale, we want to understand the local repartition of the zeros and the interaction between neighboors. This question lead to adapt concepts from mathematical physics such as the microscopic renormalized energy to the study of zeros of random polynomials. Recent studies also linked the local behavior of zeros of random polynomials to the zeros of Random Analytic Functions, which have a lot of connexions to several domains in mathematics (Analysis, Image processing, random matrix theory, mathematical physiqucs). The concept of renormaliazed energy is very recent (2017), and was introduced by Leblé and Serfaty to understand the local behavior of particles from a Coulomb gas. We think that this approach can lead to a new understanding of the behavior of zeros of random polynomials.

Mots clés : random polynomials, coulomb gases, interacting particle systems

Participants :
- University of Geneva (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet TransMetTOR (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The aim of this project to investigate the role(s) of mTORC2 in mRNA translation and cellular metabolism, in the context of lung cancer development. This work will be carried out in the laboratory of Dr. Pierre Close, at the GIGA-Uliège, who made seminal discoveries in the field of translation regulation and cancer biology. This ambitious project will bring an opportunistic synergy between the expertise in cancer metabolism of the researcher, Dr. Blomme, and the knowhow in translation regulation of the host laboratory. In addition, the project relies on the combination of cutting-edge unbiased “omics” approaches and involves the characterisation of unique mouse models recently generated in the host lab. It is further supported by four high-profile international collaborations that will provide essential technical expertise in metabolomics and lipidomics, and support the clinical aspects of the proposal. As part of an interdisciplinary training, Dr. Blomme will carry out a secondment in the translational research group of Prof. Vooijs, at Maastricht University, in order to learn ex-vivo organoid models of lung cancer. The proposed project addresses fundamental questions of cell biology in a highly clinically relevant context. As such, it holds the potential to result in the design of future anticancer therapeutic strategies. Indeed, the mTORC2 pathway is very often dysregulated in lung cancer. Therefore, by deciphering the molecular mechanisms that sustain mTORC2-dependent metabolism, this work will provide innovative strategies to target mTORC2 signalling in lung cancer.

Mots clés : cancer metabolism, mrna translation, mtorc2 signalling, lung cancer, mouse models

Participants :
- University of Liège (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166320.0 €
Projet ExpBoD (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The aim of this project, Measuring Experienced Disease Burden (ExpBoD), is to deliver a proof of concept to systematically measure disease impact across multiple non-health dimensions (e.g., economic, psychological impacts) and diseases using Denmark as a testing ground. As seen during the coronavirus pandemic, governments worldwide are expected to manage not only the disease burden of COVID-19 but its impact beyond health. Yet, existing metrics on measuring population health, such as deaths, prevalence, disability- and quality-adjusted life-years (DALY and QALY) do not capture aspects beyond health, and current methods are not equipped to systematically estimate multiple non-health disease impacts across diseases. I will systematically estimate the disease impact across five dimensions: economic, social, psychological, physical, and healthcare and welfare impacts. ExpBoD will (1) assess statistical methods to identify the most appropriate methodology, (2) systematically estimate disease impact across dimensions and diseases, conduct sub-group analyses, and (3) create a composite index for experienced burden. By providing a comparable metric of broader aspects of disease burden, this research will advance the literature in health metrics and improve the evidence base for priority setting in the real world. The unique opportunity that the fellowship provides will allow me to build this long-term and policy-relevant research agenda and propel me into a successful future academic career.


Participants :
- University of Southern Denmark (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 219312.0 €
Projet PINQ (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The annual meeting of the World Economic Forum (WEF) in Davos, 2015, identified deepening inequality as the most pressing challenge facing the world. High inequality is liked to numerous social problems, as well as to greater economic instability. Concern for these problems is not only restricted to highly educated, socio-political elites (e.g. the WEF). Large-scale surveys in several countries have shown that people generally have a preference for greater equality. However, despite broadly shared egalitarian ideals, people often oppose policies aimed at reducing inequality and support policies that would have the opposite effect . I will call this the principle-implementation gap in attitudes towards inequality. The primary aim of this project is to understand the reasons for this gap, by applying knowledge from social psychology to current work on inequality from the disciplines of economics, political science and sociology. In particular, I will test whether similar social constraints, cognitive biases and psychological motives that explain other inconsistencies between peoples ideals and their attitudes, can also be used to explain this particular principle-implementation gap. I will draw on methods used across the social sciences, including longitudinal and multilevel modelling of large-scale, cross-national survey data, and carefully controlled laboratory experiments. This multidisciplinary endeavour will provide insights to policy makers, advocates and educators about how to communicate the problem of inequality to the general public in a way that maximises awareness and engagement. These insights will also be applicable to understanding what drives public opinion on other, similarly complex issues of resource distribution that face modern societies (e.g. international trade). Thus, this project will shed light on how some of the biggest global issues of our time can be addressed through the democratic process.

Mots clés : inequality, identity, ideology, power, wellbeing, social change

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet MGLycan (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The appearance of aberrant glycans on the tumor cell surface is one of the emerging hallmarks of cancer. Tumor growth is accompanied by tumor evasion of the immune system which limits the efficacy of cancer vaccines. However, and despite the fact that aberrant tumor glycosylation alters how the immune system perceives the tumor and, can also induce immunosuppressive signaling through glycan-binding receptors, the role of tumor glycosylation in immune evasion has mostly been overlooked. It is clear that new strategies to avoid the immune escape mechanisms generated by tumor cells are required. The interaction between the immune system and Tumor-Associated Carbohydrates Antigens (TACAs) is facilitated by a diverse set of carbohydrate-binding receptors, as the C-type lectin receptors (CLRs) which mediate specific interactions with TACAs controlling many features of the immune response. The immune escape mechanisms generated by truncated O-glycans, such as Tn antigen (αGalNAc-Ser/Thr) are still poorly understood. Human macrophage galactose-type lectin (hMGL) is a CLR that recognizes terminal GalNAc moieties, and is, therefore, a prime receptor for the aberrant O-glycans in cancer. MGL is upregulated in tolerogenic and immature dendritic cells (DCs) and macrophages playing an important role in immunosuppression. It interacts with effector T-cells, resulting in reduced proliferation, cytokine secretion and induction of T-cell apoptosis. In this project, we propose the design and synthesis of multivalent MGL ligands mimetics with an improved affinity toward this receptor, that will serve as selective inhibitors to reverse GalNAc-mediated immune suppression for cancer immunotherapy.

Mots clés : carbohydrate, lacdinac, galnac, hmgl, enzymatic synthesis, glycomimetic, click chemistry, microarray, binding assays, multivalency, neoglycoprotein based nanoparticle, dendritic cell, immunoresponse

Participants :
- CIC biomaGUNE (Espagne) — Coordinator, beneficiary, Recherche, subvention : 172932.48 €
Projet PreAniMod (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The art of the early 20th Century in Europe was characterized by an intense interest in "primitive" cultures, and, not coincidentally, some of the first Paleolithic cave paintings (Altamira in 1868; Font-de-Gaume in 1901) had been discovered at the "moment of Modernism." Franz Marc wrote that the purpose of the „animalization“ of painting was to "lead us back to the sources of art." My project, in collaboration with the Arkeologisk Museum / UiS under the guidance of Dr Kristin Armstrong Oma, explores the relationship between avant-garde art, its prehistoric precursors, and contemporary inheritors to shed light on the image of the animal in the history of art and archaeology and to challenge anthropocentric assumptions underlying traditional research, demonstrating that memory and imagination are as crucial skills as close observation to represent the livingness and sentiency of animals. The prospect of bringing modernist art history and archaeology into conversation is a unique benefit of basing this project within the Museum's "Animals Mediating the Real and Imaginary" research initiative, as learning about archaeological is crucial to bringing my research alive. The door of hope is still ajar for humans to help save some of the earth's life forms. Can images change our actions as well as our aesthetics? Avant-garde artists were drawn to imagining a primitive utopia during a time of upheaval and crisis. This project includes an exhibition organised with Oslo's contemporary LOCUS gallery director Tanja Thorjussen, with public engagement and round-table discussions as well as conservation expeditions to the Alta cave site. A monograph and exhibition catalogue will document my research.

Mots clés : utopia, german modernism, magdalenian, aurignacian, iron age, cave art, animal figurines, painting, sixth mass extinction, animals in art, contemporary art, activist art, ecofeminism, museum studies

Participants :
- University of Stavanger (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €