Projet HeatNMof (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : SIGNED

Although recent advances in nanotechnology have provided an excellent platform to revolutionize the domain of health, the efficient and target delivery of many potent drugs in the body still remains an important challenge due to important drawbacks either from the drug (bioavailability, toxicity, etc.) and/or from the nanocarrier (biocompatibility, reproducibility, insufficient targeting). Consequently, there is currently a real demand for drug nanocarriers able to solve these matters for the different administration routes. HeatNMof project aims to develop smart multifunctional nanocarriers of challenging antitumoral drugs based on versatile highly porous biocompatible nanometric Metal Organic Frameworks, associated with exceptional drug payloads and controlled releases, and photo- and/or magnetic inorganic nanoparticles, providing both a specific control of reactions inside living entities (i.e. heating-triggered drug release) and additional properties such as imaging (magnetic resonance, thermal or optoacoustic imaging) and/ or hyperthermia therapy. The successful development of this project, involving academic and industrial partners, will contribute to the improvement of the highly societal relevant cancer therapy. This research objective is strongly related with the prime training/networking aim of HeatNMof: to train the next generation of materials scientists in a highly interdisciplinary and intersectorial research environment, such that they can soundly address upcoming challenges concerning nanomedicine, from the development, optimization and (physicochemical and biological) characterization of inorganic and hybrid materials, as well as their interaction with living entities, with a strong focus on drug delivery platforms based on nanomaterials. HeatNMof will train the next generation of material scientists with sound expertise in nanomedicine, highly needed to bring advanced materials as proposed from the bench to society.

Mots clés : plasmonic nanoparticles, magnetic nanoparticles, metal organic frameworks, drug delivery

Participants :
- University of Santiago de Compostela (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 250904.88 €
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 529688.09 €
- Italian Institute of Technology (Italie) — Partner, beneficiary, Recherche, subvention : 566581.92 €
- Isern patentes y marcas m sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 250904.88 €
- Nanoscale biomagnetics sociedad limitada (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 32235.01 €
- University of Antwerp (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 256320.0 €
- Institut national des sciences appliquées de Toulouse (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 421973.04 €
- Immaterial Labs (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 303172.56 €
- Universität Hamburg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 274802.04 €