Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet AdapTT (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks - Industrial Doctorates
Panel : Life Sciences
Statut du projet : CLOSED

AdapTT will unlock the potential for development of a real time adaptive therapy planning tool for thermal treatment in prostate oncology. Highly specialized and cost effective state-of-the-art scientific solutions can only be developed when complimentary partners of different sectors work synergistically. The intersectoral nature of the European Industrial Doctorates (EID) framework, between industry and academia, is a key requirement for success of the proposed PhD projects. Specific application knowledge on clinical software platforms development, imaging systems and therapy modalities of the industrial partner, has to be combined with fundamental biophysical knowledge and clinical need insights of the clinical academic partner. This combination of European based expertise is unique and being able to be exposed to these different research climates will strongly enhance the employability and career prospects of the early stage researchers (ESR’s), participating in the program. The objectives of AdapTT are: 1. To train and to deliver a cohort of young researchers experienced in transcending traditional research boundaries to deliver deeper insight into energy dose delivery of thermal therapy modalities such as high intensity focused ultrasound (HIFU), microwave, laser and radiofrequency (RF) in soft tissue; 2. To discover and leverage deep understanding of the molecular, cellular and biophysical impact of temperature on tumour cell behaviour and healthy soft tissue properties; 3. To develop a therapy planning tool, based on a combination of pre-clinically validated 3D energy dose delivery biophysics models and mathematical algorithms to enable real time energy monitoring and real time energy delivery adaptation; 4. To significantly impact EU competitiveness by bringing leading science- and technology experts together to work on basic- and translational problems from both academic and industrial viewpoint.

Mots clés : thermal therapy, therapy planning, oncology care, biophysics modeling

Participants :
- Universitätsklinikum Aachen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Philips (Netherlands) (Pays-Bas) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 766122.84 €
- Eindhoven University of Technology (Pays-Bas) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet FROOTS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Adaptation to environmental conditions is key to maximise crop productivity under limited water and other stresses related to climate impacts. Combining stress resistance with desired agronomic characteristics through regular plant breeding in fruit trees such as olive requires a huge amount of time and resources and might not be feasible by just using the current available genetic pool. However, the use of rootstocks could overcome some of these stresses that are challenging tree crops worldwide and allow to unlock the genetic potential of wild relatives of olive. The objective of FROlive is to speed up the rootstock breeding process in olive trees by developing accurate, fast phenotyping and grafting methodologies for the early selection of new olive rootstocks, in first instance for drought resistance. This will be done by using techniques that are known to the applicant due to his background in plant breeding and disease resistance screening and analysis techniques, in collaboration with the hosting group, which has a strong track record in the study of olive germplasm resources, genetics and breeding, as well as proven ability to train students and scientists. The approach and techniques used in FROlive will allow a faster development of rootstocks resilient to new challenging environments and pests, therefore reducing the environmental impact and future proofing our olive orchards. The training will allow the applicant to be trained as a fruit tree breeder, increasing the capability in this research area. The project presents a multidisciplinary approach as it brings together plant propagation, germplasm resources, genetics and statistics. It also represents a collaboration of five different partners, the University of Córdoba, the Swedish University of Agricultural Sciences, the University of Málaga, the Institute for Sustainable Agriculture and the company Plantas Continental, S.A., opening the possibility for further collaboration between the institutions.

Mots clés : drought resistance, olea europaea, rootstock scion interaction, grafting

Participants :
- University of Córdoba (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet MOAI (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Adaptive optics (AO) together with sodium laser guide stars (LGS) have revolutionized astronomical observations in the last decades. The new generation of Extremely Large Telescopes (ELTs) will require and integrate AO-assisted observations to comply with their scientific programs, however, extrapolating the current AO technology to the dimensions of the ELTs encounters technological barriers (large, sensitive, and fast detectors) and fundamental limitations derived from the geometry and properties of LGS (spot elongation and tip-tilt indetermination). Therefore, the aim of the MOAI project is to develop MethOds And Instrumentation for laser guide star wavefront sensing (LGSWFS), in view of the challenges imposed by the future ELTs. Three specific goals are foreseen, namely: i) evaluate the feasibility of LGS tip-tilt correction using the polychromatic laser guide star concept, ii) investigate and propose an innovative concept of LGSWFS for ELTs, and iii) demonstrate a new LGSWFS technology. The project will be carried out at the Laboratoire d’Astrophysique de Marseille (LAM) in 24 months. The first and second exploratory-research goals will be accomplished by testing and modeling new LGSWFS concepts using state-of-the-art AO facilities and software developed at LAM, in addition to numerical simulations of LGS. The third goal will be realized through the implementation of an LGSWFS prototype in the laboratory, and post validation of its performance with an on-sky experiment at AO facilities in La Palma. The combination of local AO expertise with the experience of the fellow in LGS will be essential for the success of this project. Achieving the objectives will considerably extend the capabilities of AO-assisted observations, which will constitute a significant contribution of the European action and the fellow to enable new astrophysical discoveries in the upcoming era of ELTs.

Mots clés : adaptive optics, laser guide star, wavefront sensing, sodium layer

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 184707.84 €
Projet MFILAMUXIAML (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Additive Manufacturing (AM) has been a hot topic for many years. A fundamental understanding of the metal flows in the molten pool is critical to improving the quality of the sample produced by AM. Laser metal deposition (LMD) is one of the most widely used AM methods, which has a high production efficiency, and a special application in repairing the damaged parts with large size and high price. During the LMD process, a powdery filler is injected from the nozzle onto the surface of the base metal, and a laser beam is used to melt the powders and surface of a specimen. Dynamics of the keyhole and molten pool will determine the temperature distribution and the profile of the molten pool, thus affecting the microstructure of the printed bead. It is difficult to observe the dynamics of the molten pool in AM directly with a camera because the molten pool is surrounded by the solid metal. The objectives of this proposal are to reveal the dynamic characteristics of the keyhole and molten pool in LMD and provide a guide for choosing the proper production parameters for defect-free AM. To achieve the objectives, the X-ray imaging system in the host institute will be used to observe the dynamics of the keyhole and molten pool. With the high-melting-point tungsten particles as the tracers mixed with the metal powders, the flow of the liquid metal in the molten pool could be observed. The machine learning technique is then used to track the flow of the tungsten particles, which makes the quick determination of the flow routes and velocities of the liquid metal possible. The novelty of this proposal is that the x-ray imaging method combined with the machine learning technique is first used to visualize the dynamics of the keyhole and molten pool in LMD. This research could provide a guide for optimizing the process parameters and improving the AM quality, and the achievement of this research could contribute to the development of LMD in the industry.

Mots clés : x ray imaging, additive manufacturing, laser manufacturing, machine learning, in situ, welding

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet A_MADAM (Horizon 2020, appel à projets 2016)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : CLOSED

Additive manufacturing (AM) belongs to key enabling technologies where Europe has the leading research role. The AM technologies put considerably fewer limits on shape of the manufactured objects than conventional technologies, and offer unparalleled freedom to industrial and mechanical designers. Since the AM technologies are insensitive to production scale, they put in focus knowledge and creativity of designers instead of low prices of mass production, paving the way to development of new business models. The AM technologies, therefore, represent a technology platform that may best serve Europe in its intent to develop knowledge-based economy, driven by innovation. However, the industrial deployment of AM technologies is hindered by a gap that exists between the excellent research and its exploitation in industry. The research knowledge about the AM technologies is published in scientific journals and in conference proceedings, in form suitable for researchers. On the other hand, industrial and mechanical designers use sets of design rules, which represent condensed and comprehensive form of the research findings that are easy to follow. The lack of sets of design rules for AM technologies is one of important reasons why engineers often prefer conventional technologies to AM. The proposed project intends to use the research capacities and partnerships developed in previous EU funded projects to carry out systematic studies of dynamic mechanical properties (fatigue, fracture mechanics and impact resistance) of products manufactured by AM with the goal to establish the proper rule sets for design of products. Since the aim of the project is to “translate” the research findings into engineering rules, the consortium consists of two universities and three SMEs that use AM technologies for rapid prototyping, rapid manufacturing and rapid tooling. The project activities will be realized as two-way transfer of knowledge between the industrial and academic partners.

Mots clés : additive manufacturing, selective laser sintering, rapid prototyping, ralid tooling, rapid manufacturing

Participants :
- Topomatika trodimenzionalno skeniranje, opticki mjerni sustavi i racunalna obrada doo (Croatie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 54000.0 €
- University of Bologna (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 72000.0 €
- Plamingo doo, company for domestic and foreign trade, production and services (Bosnie-Herzégovine) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 54000.0 €
- University of Kragujevac (Serbie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 234000.0 €
- Studio pedrini srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 54000.0 €
Projet AI2AM (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Additively Manufactured fibre reinforced composite (AMC) components manufactured via fused deposition modelling (FDM) rapidly find applications within the European aerospace and transport industry , due to their well-known advantages mainly relating to less machine, material and labour costs, less manufacturing waste, and usage of more efficient materials. A major drawback of AMC components is their usually complex and in cases tessellated geometry; this gives rise to combined (e.g., fibre pull-outs and matrix cracking) and quasi-brittle damage mechanisms that deviate from the usual “high strength and ductile metal” design paradigm. Such a “complexity”, if controlled, can result in components of tailored mechanical properties, e.g., of increased fracture toughness and pseudo-ductile post fracture response. Unfortunately, current analysis and design methods lack the necessary level of refinement, or the underlying theoretical framework indeed, to efficiently address this critical issue. AI2AM aims to deliver a holistic approach to additively manufacture topologically optimum composite components of increased fracture toughness. It will achieve this by developing a state-of-the-art fracture simulation framework for composite structures harnessing the fidelity and computational advantages of phase field modelling for fracture and scaled boundary finite element methods. This high fidelity physics based "continuum toolbox" will be used to train surrogate models based on machine learning methods. The surrogates will then be deployed within a novel topology optimisation framework to deliver optimal and 3D printed geometries. The envisaged methodology crosses the boundaries of computational mechanics, optimisation, and machine learning and brings together a talented academic with world-class experts in topology optimisation, composites, and additive manufacturing.

Mots clés : phase field, scaled boundary finite element methods

Participants :
- National Technical University of Athens (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165085.44 €
Projet MINPOL (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Addressing a recent trend of mine reopening in southern Europe, the project will analyse the relationships between mining policies, expectations of employment and grassroot politics in times of economic crisis. On the basis of an ethnographic case study located in southwest Spain, the project will study mining revival from policy-making to its local impact on working-class families involved in the re-opening of a historical mine. The MINPOL project aims at shedding an innovative light on how economic and political order is produced, maintained but also challenged locally. Drawing upon the concept of “industrial citizenship”, which stresses the role of industry in the constitution of political subjects, on the work scene and beyond, this project will study political subjectivities arising from hopes of re-industrialization in European rural societies. Beyond the specificities of the economic sector and of the geographic setting, this research will contribute to the study of grassroots politics, emphasizing the prevalent importance of work while questioning how the economic policies in times of crisis transform the way (un)employment shapes daily life and subjectivation processes. The project will be conducted along three paths of investigation. 1. It will study Spanish mining policy, analysing the appropriation of economic doctrines from European to local scale, paying particular attention to the diffusion of policy narratives and devices. 2. Focusing on (former) miners’ families, the project will study local impacts of mining revival policies. Moving from the industrial world and the work-scene to the surrounding villages, it will analyse the renewed importance of mining industry in production and reproduction practices, and its influence on social identities. 3. Investigating public spaces, associations and collective action, it will scrutinize discrete processes of politicization that arise from ordinary sociality and (re)productive practices.

Mots clés : mining industry citizenship southern europe

Participants :
- University of Barcelona (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet SALMYB (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Adenoid cystic carcinoma (ACC) is both a rare disease (limited scientific data and professional expertise) and a cancer (complex tumour biology and evasion of conventional therapies). Clinical behaviour differs depending on primary tumour site; salivary gland ACC has poorer prognosis than breast ACC. A majority of ACC harbour MYB rearrangements resulting from chromosomal translocations, with the fusion of MYB and NFIB or MYBL1 and NFIB being the most frequent. The role of translocations in tumourigenesis and whether cells from different primary sites respond differently has not been determined. Identification of specific cell types carrying the translocation and location within the tumour microenvironment might enable development of MYB target-therapies. Our main objective is to elucidate the function of MYB rearrangements in normal salivary and mammary gland cells and the expression of the novel fusion genes in salivary gland and breast ACC. Normal human cells will be transfected with MYB-NFIB and MYBL1-NFIB fusion transcripts and fusion negative, fusion positive and combinations of cells will be compared in terms of cell morphology, differentiation, proliferation, migration and invasion. 3D models, more closely mimicking an in vivo tumour, will be compared to monolayer cultures. In situ localisation of MYB-NFIB and MYBL1-NFIB in salivary gland and breast ACC will be assessed using a novel technology, BaseScope. This ambitious research project will determine the consequences of MYB rearrangements using state-of-the-art methods in molecular and cellular biology, genetic and tissue engineering and pathological anatomy. The project has clear translational potential with social, cultural and economic impacts. Transfer of results to other cancers harbouring MYB rearrangements (eg leukaemia, colon cancer) and our methods in assessing other tumours characterised by chromosomal translocations, eg prostate, colorectal and non-small-cell lung cancer, are further outcomes.

Mots clés : chromosomal rearrangements, salivary gland cancer, breast cancer

Participants :
- University of Sheffield (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet FemTHEATRE (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Adopting an interdisciplinary approach that combines feminist theory, Italian Studies, and women’s writing for theatre, this project will offer the first full-length investigation of the entwined dynamics between the rise of active feminism in 1970s Italy and the coeval theatrical practice. The twofold research objective represents a novelty with respect to the scant existing criticism on the subject. The study will 1) look at how the dramaturgical served as an ideological vehicle for feminism in rethinking the representation of women’s gender roles and 2) assess the impact of feminist ideology in rupturing established dramatic conventions. To better achieve this scope, it will be articulated on three main grounds: i) contextualisation of feminist theory and practice in Italy ii) philological and theatrical analysis of a wide-ranging corpus of plays produced at the time iii) collection of first-hand testimonies. This project will benefit from a unique blend of competences between the researcher and internationally established experts from the Departments of Italian Studies and Theatre Studies at the University of Milan that, combined with intense training, will allow the researcher to reach a position of professional maturity. While promising to make a significant contribution to academia by developing new knowledge in the field, the project also recognises the importance of the research topic for a wider audience. Particular attention will be given to dissemination and audience development activities, including the realisation of a number of performances intended to raise awareness of feminist issues and the topicality of feminist matters nowadays among theatre audiences and the general public. Whilst focusing on the Italian context, this study will also fill a vacuum in Women’s and Gender Studies by establishing a connection between a historically circumscribed form of artistic output and its sociological and historical context that is hitherto lacking.

Mots clés : women s studies, women s writings, feminism, gender theory, italian studies, european theatre studies

Participants :
- University of Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 168277.2 €
Projet AVAST (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Advanced Volcanic Ash characteriSaTion I aim to show how rapid characterisation of volcanic ash particle properties using QEMSCAN® Particle Mineralogical Analysis, an automated mineralogy tool, can help to determine risks to aviation and interpret deformation during volcanic eruptions in order to help predict and respond to volcanic crises. Through targeted experiments using specialised experimental apparatus, together with checks from cross-correlation and control samples, I will adopt an empirical approach in order to (1) characterise ash particles to identify diagnostic characteristics linked to fragmentation mechanisms that can be used to better inform ash-plume dispersion models and turbine engine resilience tests and to predict ash particle properties during monitored volcanic deformation and (2) challenge conventional wisdom that volcanic deformation is regulated by the strength of ‘intact’ magma and edifice rock and constrain the effects of phase distribution on ash sintering by conducting deformation experiments on progressively sintered ash samples. Through AVAST I will receive training in cutting-edge research techniques and establish intersectoral partnerships, helping to realise my goal as an independent research group leader in volcanology.

Mots clés : volcanic ash, automated mineralogy, qemscan  r, particle characterisation

Participants :
- Ludwig-Maximilians-Universität München (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171460.8 €