Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CELTMED (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

In Western Europe, the onset of the Iron Age implied a series of critical cultural and technological changes that were to a large degree connected with the development of contact and exchange networks with the Mediterranean World. New cultural influences, involving different traditions of land and resources management, spread especially from Greek colonies into the sphere of the rising Celtic civilization, where they merged with autochthonous dynamics and promoted changes in social structures, economic and productive systems and land use. However, very few studies have openly addressed the environmental and landscape consequences of the Greek colonization in the Celtic world, and thus its impact and role in the shaping of Western European cultural landscapes remains largely overlooked. To fill in this gap, CELTMED will employ an integrated multidisciplinary approach merging palaeoecology and geoarchaeology in three selected sites subject to different degrees of Greek influence: Abdera, an Aegean colony representing the genuine landscapes of the Greek World; Corent, a Gallic oppidum in central France exemplifying genuine Celtic landscapes; and Lattara, an hybrid Celtic site with a harbour under important Greek influence, located in the contact area of both civilizations in the coastal wetlands of SE France. CELTMED will use high-resolution, multi-proxy palaeoecological and geoarchaeological analyses of sedimentary archives, combined with archaeological data, to reconstruct and compare socio-environmental dynamics and landscape change across this transmediterranean geographic and cultural transect from coastal Greek to Continental Celtic worlds. This will allow to explore how the interplay between both cultures from the early Iron Age changed the way Celtic societies interacted with their environments and contributed to the shaping of cultural landscapes in the Celtic area, providing a new and more comprehensive knowledge of the history of Western European landscapes.

Mots clés : palaeoenvironment, geoarchaeology, landscape evolution, socio environmental interaction, human impacts, fire history, non pollen palynomorphs, malacology, mediterranean, greeks, celts, iron age

Participants :
- Université de Montpellier (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet SOUNDCHANGE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Species are often predicted to lag behind the unprecedented pace of ecological changes imposed by current human activities. Such changes result not only in modification of the mean environmental values in an ecosystem but also in increasingly extreme and variable environmental conditions. These extreme and variable conditions operate at fine spatio-temporal scales. A mechanistic understanding of these dynamics in response to new environmental conditions thus requires monitoring, analysing and modelling at such fine spatio-temporal resolution. Passive acoustic monitoring (PAM) is a rapidly growing field of research that allows for an unparalleled temporal resolution and a wide taxonomic diversity of sound producing species in terrestrial and aquatic environments. In this context, I will use PAM to understand fine scale spatio-temporal community dynamics in response to increasingly extreme and variable environmental conditions. For that I plan to develop a methodological and conceptual framework to understand community dynamics at unprecedented spatio-temporal resolution. First, I will use unsupervised learning to characterise acoustic community composition, creating acoustic groups that I will ecologically identify. I will then use these groups to assess spatio-temporal variation of community composition in these environments and their associations using network models. Finally, I will use different change scenarios to investigate the potential impact of these changes on community dynamics. This research will increase our understanding of the importance of extreme and variable environmental conditions in driving community dynamics.

Mots clés : ecoacoustics, community ecology, global change

Participants :
- Université Grenoble Alpes (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 152623.68 €
Projet LSDAP (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Speakers of even highly irregular inflecting languages can usually produce all forms of all lexemes (e.g. do, does, did…). How they can do so on the evidence of skewed and partial input is known as the Paradigm Cell Filling Problem. The increased availability of large inflected lexicons, and computing power and tools to assess cell-to-cell predictive uncertainty have enabled us in recent years to automatically measure multiple aspects of paradigm complexity and structural similarity. Unfortunately, this quantitative turn in morphology has been almost entirely limited to synchronic analyses. This project seeks to harness the power of novel quantitative methods (e.g. Information and Set Theory, Bayesian models) for the study of paradigmatic change as well. The focus will be on Romance verbs, as the most historically documented and best-understood inflectional system worldwide.  Regarding synchronic variability, I will integrate the best and largest extant inflected lexicons in the family (5000+ complete verbs for the 5 largest Romance languages and Latin). All forms will be annotated for lemma-level and cell-level cognacy to produce a reusable and expandable pan-Romance etymological inflected lexicon. Turning to diachrony, one of the greatest obstacles to analyzing morphological change is distinguishing it from regular sound change. Given the large number of words and changes it is impossible to derive an optimal chronology of sound changes by hand. I will therefore write software that applies sets of ordered sound changes automatically to large inflected lexicons (e.g. of Latin) to derive expected forms. Comparing these to actual forms will reveal where morphological changes have occurred historically and enable us to explore what the best predictors are of analogical change: frequency, predictability, meaning, etc. This will allow us to evaluate more tractably competing hypotheses of phonological and morphological change and trends of change.

Mots clés : morphology, linguistics, paradigm, romance languages

Participants :
- Université d'État de l'Ohio (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet AnisoTEP (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Conducting polymer (CP) based thermoelectric materials (TE) gained significant interest from the scientific community due to their natural advantages such as low cost, high flexibility, lightweight and low toxicity over inorganic materials, which is beneficial for wearable or portable devices. Despite the benefits of organic TE materials, their low electrical conductivity reduces the TE performance and hinders commercialization. Chemical doping can be used to improve the electrical conductivity of CPs as it increases the charge carrier (polarons) concentration. However, the main limiting factor of electrical conductivity in organic semiconductors is their poor structural order and crystallinity. In addition, the strong coulombic attraction between the formed polarons (carriers) and the dopant counter ions hinders carrier delocalization, further limiting the TE performance. AnisoTEP will focus on developing highly conducting and crystalline polymer thin films to achieve high TE performance. We will use methods based on epitaxial orientation and mechanical rubbing to prepare oriented and crystalline P3HT thin films. Once oriented and crystallized, thin films will be doped by unique dopants based on dodecaborane (DDB) clusters, which stabilize their electron density in their core, and the negative charge of the DDB anions stays far away from the polarons, leading to a more delocalized polaron and high conductivity. Novel doping strategies based on ion exchange will be used to introduce counter ions of different ionic radii into P3HT to investigate the impact of counterion size on the polaron delocalization and TE performance. All the anisotropic TE parameters will be estimated, including the anisotropy in thermal conductivity and the final ZT anisotropy. This work would be the first attempt to experimentally determine the mobility anisotropy and charge transport mechanism in oriented polymers by AC Hall effect measurement.

Mots clés : conducting polymers, doping, polymer orientation, organic thermoelectrics

Participants :
- University of California System (Etats-Unis) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 300441.6 €
Projet CardioReGen (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

During acute myocardial infarction (MI), up to 25% cardiomyocytes (CMs) in the left ventricle can die, which plays a major role in the progression to heart failure (HF). This loss is not compensated by new CM generation as, in adulthood, CMs lose their capability to proliferate. Recently, the host laboratory has proved that cardiac regeneration after MI can be stimulated by the therapeutic administration of various miRNAs in both mice (Eulalio et al., Nature, 2013) and pigs (Gabisonia et al., Nature, 2019). However, these studies also highlighted the safety issues related to the use of adeno-associated viruses for gene delivery. Here, we want to design a novel therapeutic treatment to regenerate infarcted hearts based on the administration of selected pro-proliferative miRNAs delivered through lipid nanoparticles, which have been recently approved clinically for other conditions and offer an unprecedented translational possibility to stimulate cardiac regeneration. The effects of treatment will be comprehensively characterized, both functionally and structurally, at both cellular and organ levels, using a novel reporter mouse in which replicating cells become genetically labelled. We will monitor cardiac function and analyze the number of replicating CMs, as well as angiogenesis and molecular and cellular parameters related to HF. By taking advantage of my expertise, we will perform whole-organ, high-resolution 3D reconstructions of the regenerated hearts, employing cutting-edge optical imaging platforms (Olianti et al., PBMB, 2021). The spatial distribution and arrangement of proliferating CMs, connexins and fibrotic patches will be mapped and quantified in 3D. For each heart, structural information will be correlated to functional analyses. The findings of this project will provide novel and important information on the molecular, functional and structural correlates of cardiac regeneration, which is essential to support therapeutic development in this field.

Mots clés : cardiac gene therapy, myocardial infarction, mirnas, cardiac regeneration, optical imaging for whole heart 3d reconstructions

Participants :
- Université de Londres (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet MATRIX-MeV (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The capabilities of chemical composition nanoscale mapping are of utmost importance for the advance of microelectronics, power storage, cellular biology, 2D and quantum materials, sensors, photovoltaics, etc. Molecular distribution can be precisely analyzed with secondary ion mass spectrometry (SIMS). MeV-SIMS is a version of this technique capable of detecting high-mass molecules exceeding 1 kDa with primary ions of MeV energies used for molecular desorption. Regardless of the type of SIMS, there are limitations, with the most important ones being low ionization yields between 0.1% and 10% and the matrix effect. They negatively affect the detection limits and almost entirely prevent quantitative analysis. The objective of the project is to overcome these limitations by implementing approaches for ionization enhancement and matrix-effect reduction. The hypothesis is that the main process crucial for achieving this is proton transfer. Changes in the ionization potential as a consequence of the introduction of proton-donor or acceptor organic matrices will be evaluated and cluster secondary ion formation during recombination of the analyte and the matrix will be studied. The formation of these cluster ions via electronic excitations occurring during sputtering will be the basis for the explanation of the recombination mechanisms. Our findings will be implemented in the field of innovative nano-imaging of the chemical composition of organic and biological samples. The research will be conducted on a ToF-SIMS instrument coupled with a state-of-the-art MeV accelerator, while testing different approaches for the deposition of solid and gaseous matrices. The combination of the candidate’s knowledge of the chemical aspects of the ionization and matrix effect, the supervisor’s experience in the field of MeV-SIMS and ion-beam analysis, and the excellent equipment at the facility will be the basis for the successful implementation of this interdisciplinary project.

Mots clés : secondary ion mass spectrometry, surface analysis, analytical chemistry, accelerator based techniques, ultra high vacuum

Participants :
- Institut Ruđer Bošković (Croatie) — Coordinator, beneficiary, Recherche, subvention : 171791.76 €
- Université de Kyoto (Japon) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet R-evolution (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The effect of ploidy and genome organization on evolution and adaptation is a central question in biology. Most organisms contain a single nucleus per cell, irrespective of their genome size and ploidy level. The kingdom Fungi represents a notable, yet significantly understudied, exception. Most fungal species partition individual haplotype genome copies into discrete nuclei. What evolutionary advantages arise from partitioning different haplotypes into multiple nuclei is a fundamental and unsolved puzzle in eukaryote genomics. This project addresses several questions that will improve our fundamental understanding of multinuclear genome biology by identifying genetic and epigenetic inter-nuclear differences in the stripe rust fungus (Puccinia striiformis f. sp. tritici, Pst). In contrast to diploids, it partitions its two haplotypes into two distinct nuclei (dikaryon). It is one of the most harmful wheat pathogens with significant impacts on global wheat production and food security. Pst epidemics in wheat growing regions including Europe and Australia have been dominated by lineages that reproduced exclusively asexually for decades. The haplotypes of the asexually evolving lineages diverge over time through independent accumulation of genetic variation. In this proposal I will dissect how the presence of multiple nuclei in the same cytoplasm in rust fungi contributes to rapid adaptation to variable and changing agricultural environments. Understanding the underlying mechanisms that drive rapid evolution of new genotypes in absence of sexual recombination is important to make predictions about durability of host resistance and management strategies.

Mots clés : fungal plant pathogen, genome evolution, chromatin, rust fungi, long read sequencing, rapid adaptation, dikaryon

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 284484.48 €
- Université nationale australienne (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ABCD (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Mathematics
Statut du projet : CLOSED

This proposal aims at addressing classical problems about the braid group by making use of recent advances in higher representation theory. More precisely, I want to use Khovanov-Seidel categorified Burau representation and Bappat-Deopurkar-Licata's work on stability conditions to work on the faithfulness problem for the Burau representation and on the Haagerup question for the braid group.  The faithfulness of the Burau representation for the 4-strand braid group is one the oldest and most tantalizing problems in braid group theory. I strongly hope that new light can be shed on it by using recent tools from higher representation theory. My strategy is to develop with Licata a ping-pong argument, which will rely on a diagrammatic description of morphisms in the category of bimodules over the zig-zag algebra. Then a fine control of the decategorification process will be needed, that I will study with Bonnafé.  Braid groups also play a major role in geometric group theory, a field of research that arose under the impulse of Gromov. Amongst open questions, knowing whether the braid groups enjoy the Haagerup property is a central one, as it has ties with several open conjectures. I plan to use Bappat-Deopurkar-Licata's work on Bridgeland stability conditions on the category of representations of the zig-zag algebra to build a space with walls on which the braid groups in type A would act. This would yield a proof of the Haagerup property for braid groups in type A.  Both of these work problems are major challenges in braid theory, and my approach to study them will create innovative mathematics entangling tools from several fields (geometric group theory, triangulated categories, diagrammatic algebra). This project will only be made possible thanks to the help of world-leading experts in Canberra and Montpellier, who will assist me in using mathematical tools I am not always familiar with.

Mots clés : braid groups categorification zig zag algebra burau representation stability conditions geometric group theory haagerup property

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 136073.04 €
- Université nationale australienne (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet TRUFA (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The proposal entitled TRUFA (TRansition metal-Uranium FLPs for the cooperative Activation and functionalisation of dinitrogen) will be developed by the candidate at the École polytechnique fédérale de Lausanne (EPFL; Switzerland, outgoing phase) and at the University of Seville (Spain, incoming phase) under the supervision of Prof. Marinella Mazzanti and Dr. Jesús Campos, respectively. The goal of the proposal is to develop cooperative transition metal-uranium functionalisation catalysts by exploiting a Frustrated Lewis pair approach. The isolation of transition metal-uranium bridged dinitrogen complexes would represent a fundament development in Inorganic Chemistry as well as provide access to a range of studies concerning the cleavage of the N-N bond and the catalytic formation of N-H and N-C bonds en route to ammonia and organonitrogen compounds, respectively.

Mots clés : frustrated lewis pairs, f element, n2 reduction, n2 functionalization

Participants :
- École polytechnique fédérale de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Séville (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209749.51 €
Projet SpaCIIS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The 'Spatialising Career Interventions for Inclusivity and Sustainability' (SpaCIIS) project aims to address rural sustainability through the unusual perspective of career education and guidance (CEG) provision. Existing research shows that rural CEG provision can encourage young people to leave their rural communities and the project aims to ask whether CEG provision can be reimagined to more fully meet the needs of rural young people and their communities. The project takes an interdisciplinary approach applying insights into place-conscious practice, and place and social justice, developed in the field of rural education to rural CEG provision. Utilising Research Circles (RCs) (a form of participatory research), the project engages three rural Danish communities in researching the needs of their communities and co-designing place-conscious CEG interventions. The project contributes to scholarship in CEG by: developing a new conceptualisation of social justice for CEG including consideration of spatial aspects of inequality, and developing a new model(s) of place-conscious CEG provision. The project also extends rural development scholarship by exploring the role specifically of CEG provision in economic and population sustainability of rural communities. Contributing to rural education scholarship, the project highlights the role of CEG provision within community-education linkages and explores the value of RCs as an innovative way to bring together different perspectives and generate community led innovations in this provision. Practical outputs include the development of tools for delivering place-conscious career education that can be adapted for use across different rural communities, CEG services and CEG practitioners. Through these outputs the project seeks to improve the quality and efficiency of rural CEG services.

Mots clés : career guidance, career education, youth transition

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269236.8 €
- Studievalg danmark (Danemark) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- The University of Melbourne (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €