Projet Secreters (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

The ‘SECRETERS’ partnership aims to bring about a step change in the production of recombinant proteins, particularly Biotherapeutics and Industrial Enzymes. Both are critical products for the EU biotechnology sector, with combined markets in excess of $140 billion p.a.; the former are essential for the treatment of major diseases whereas the latter permeate every aspect of our daily life. Many proteins in these categories pose severe problems in production, especially disulphide-bonded proteins and new format 'difficult-to-express' proteins. SECRETERS will train a team of 15 ESRs to develop a new generation of super-producing microbial production hosts, including Escherichia coli, Bacillus species and the yeast Pichia pastoris. The project capitalises on a series of recent innovations and involves close collaboration between 5 academic Beneficiaries, who provide world-leading expertise in redox chemistry, synthetic biology and protein expression, and 5 non-academic Beneficiaries, who include some of the world's premier biotherapeutic and industrial enzyme companies. It will enable the biotherapeutics industry to produce challenging medicines at lower costs, resulting in new drugs and wider patient access, and allow the enzymes industry to deliver a range of powerful new products. SECRETERS will equip ESRs with the interdisciplinary and intersectoral skills required to thrive in these industries, with quality assurance systems embedded throughout the programme and a commitment to a wide-ranging dissemination/outreach programme. Based on a responsible innovation approach, with clear foci on research and entrepreneurial training, SECRETERS will deliver a team of superbly-trained scientists, poised to engage in some of Europe's most important biotechnology sectors.

Mots clés : biotechnogy, bioprocessing, recombinant proteins, biotherapeutics, industrial enzymes, esr training, microbial expression hosts, systems biology, super secretion

Participants :
- Ab enzymes gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 252788.4 €
- University of Oulu (Finlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 561611.52 €
- Austrian Centre of Industrial Biotechnology (Austria) (Autriche) — Partner, beneficiary, Recherche, subvention : 528414.48 €
- Lonza (Switzerland) (Suisse) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 281276.64 €
- Gedeon richter plc. (Hongrie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University Medical Center Groningen (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 531239.76 €
- Celltech r&d limited (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 303172.56 €
- Humboldt-Universität zu Berlin (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- UCB Pharma (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Kent (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- University of Natural Resources and Life Sciences, Vienna (Autriche) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Greifswald (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- Greifswald University Hospital (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- Biomin holding gmbh (Autriche) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Boehringer Ingelheim (Austria) (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 264207.24 €
- Polymun (Austria) (Autriche) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €