Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet bTB-Test (Horizon 2020, appel à projets 2017)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : CLOSED

Bovine tuberculosis, caused by Mycobacterium bovis and other members of the M. tuberculosis complex, is a serious global disease with significant impact on animal health, public health, and international trade. This study will focus on investigating the feasibility of a non-invasive methodology for the diagnosis of bovine tuberculosis in cattle. Our approach will be based on the detection via volatile organic compounds of the disease fingerprint in several non-invasive samples, employing analytical methods and chemical sensing devices.

Mots clés : metabolomics, biomarkers, breath, skin headspace, faeces, electronic nose, bovine tuberculosis

Participants :
- University of Pamplona (Colombie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Romanian Academy (Roumanie) — Partner, beneficiary, Recherche, subvention : 184500.0 €
- Institut Pasteur d'Algérie (Algérie) — Partner, organization partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Uppsala University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162000.0 €
- Institut Pasteur de Tunis (Tunisie) — Partner, beneficiary, Recherche, subvention : 283500.0 €
- Sitex 45 (Romania) (Roumanie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 9000.0 €
- Elvesys (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 139500.0 €
- Government of the United States of America (Etats-Unis) — Partner, organization partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Universidad Complutense de Madrid (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 409500.0 €
- Spiru Haret University (Roumanie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 207000.0 €
Projet CAJAL (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Brain aging is characterized by a progressive decline of our nervous system functions. Elucidating the underlying mechanisms is of vital importance and represents an unmet medical need. Recent studies have highlighted the molecular contribution of several organs in brain aging, and emphasize the importance of systemic milieu in the control of cognitive fitness. Host has identified Osteocalcin (Ocn), a bone-derived hormone, as a rejuvenating systemic factor that improves memory in aged-mice. However, the impact of systemic factors in our locomotor functions and their therapeutic potential remain unexplored. CAJAL aims to elucidate the role of the pro-rejuvenating hormone Ocn in the age-related motoneuron (MN) and locomotor dysfunctions. Our preliminary data show that Ocn receptor is highly expressed in spinal MNs and that Ocn influences MN autophagy, an essential endogenous mechanism for locomotor performance. We propose to analyse the potential protective role of Ocn-autophagy in MNs to maintain locomotor activity. By shedding light on key molecular mechanisms fostering MN homeostasis, CAJAL could lead to new therapeutic strategies to treat/prevent age-related decline of locomotor system. The specific objectives are: 1) Characterize the impact of systemic milieu/Ocn in regulating autophagy in spinal MNs 2) Analyze the therapeutic potential of Ocn in age-related locomotor decline 3) Decipher the role of Ocn-dependent autophagy in locomotor function and its signalling pathway The project is designed to extend my scientific expertise and transfer my knowledge in autophagy and MN homeostasis to Host. Project and risk management, intellectual property rights, and communication activities are meticulously planned. We have generated the required molecular tools and mouse models, as well as strong collaborations with international experts in autophagy, neuroendocrinology and aging. Supervisor experience together with INEM represent the best environment to develop CAJAL.

Mots clés : ageing, autophagy, locomotor performance, motoneurons, systemic factors

Participants :
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 184707.84 €
Projet STOMMAC (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Brain functions likely emerge from the concerted, context-dependent operations of its microscopic and macroscopic networks. Therefore, the organization and operational principles of such complex systems may be best investigated by using multi-modal approaches, including concurrent measurements of neural activity on multiple spatiotemporal scales. Performing and interpreting such multi-scale measures, though, presents enormous challenges for both experimental and mathematical neuroscientists. Existing analysis methods, however, make limited use of newly acquired concurrent multi-scale information. To dramatically advance analysis methods for these data, I propose a novel multi-scale model that bridges the gap between single cell statistics and neural mass signals. The model describes mixed discrete statistics, covering single cell and small population spike trains, as well as continuous statistics, such as those describing mesoscopic and macroscopic measures of mass neural activity in neuroimaging experiments. These elements are combined by means of copulas, describing multivariate interactions within and between scales of activity. I will extend this method to the level of efficient applicability and, in the course of a secondment with Prof. Logothetis at the Max Planck Institute in Tübingen, exploit the technique to solve current problems of multi-scale analysis of interactions between cortical and subcortical brain areas. The new mathematical approach will lead to a set of new tools that I will disseminate in an Open Source format for maximal impact, and will be widely applicable to multi-modal recordings in animals and humans, in both research and clinical settings. My own application of this method to multi-modal datasets will establish a deeper general understanding of the mechanisms of large-scale communication among brain areas, with particular emphasis on the principles of communication among networks involved in the formation of declarative memory.

Mots clés : probabililistic model, multi scale, multi modal, copulas, fmri, hippocampus, interactions

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 168277.2 €
Projet MoRPHEUS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Brain lesions such as stroke and traumatic brain injury are a major cause of adult-onset disability. Physical therapy, together with robotic aided rehabilitation, is the gold standard for promoting motor recovery. Yet, half of the affected individuals do not fully recover their daily living skills. Hope is provided by advanced neuroprosthetic devices, acting directly at the brain level to promote plasticity, but to date, they still fall short of producing long-lasting brain rewiring. The often neglected but close relationship between sleep, neural plasticity, pathogenesis, and recovery can constitute a key factor to advance treatment. Within this framework, the primary goal of this project is to devise and test a novel neuroprosthetic approach that monitors brain activity and the sleep-wake cycle (SWC) in order to deliver responsive and engineered electrical stimulation (ES) coded in time. To do this, we aim to: 1) investigate SWC architecture in animal models of brain lesion to better understand pathological modifications and to find privileged windows of neural plasticity to deliver therapeutic ES; 2) design, build, and test a closed-loop system capable of recording, processing and detecting SWC stages and electrographic events of interest (e.g. spindles), and also of delivering coordinated ES, including activity-dependent and time-coded stimulation, and; 3) evaluate the designed approach regarding its efficacy in providing long-lasting, robust, and safe motor rehabilitation to injured animals, while also obtaining a proof-of-concept in humans. Highly complementary skills from fellow and host will cooperate to carry in vivo electrophysiology experiments and technological development, while translational pilot experiments will be performed in close collaboration with partners in the medical field. Finally, secondments will provide additional training on state-of-the-art engineering of closed-loop systems and entrepreneurship in neurotechnology.

Mots clés : closed loop systems, motor disorders, motor rehabilitation, neuroprosthesis, sleep, stroke, traumatic brain injury

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 183473.28 €
Projet BrainMatTrain (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : CLOSED

BrainMatTrain focuses on a comprehensive understanding of Parkinson’s disease (PD), from basics to translation, fully supported by 8 full partners partner organisation (4 research institutions, 2 hospitals, 2 SMEs) and one partner organisation (SME specialist in device design). This ETN will educate and train 15 Earlty Stage Researchers (ESRs) in functioanlised biomaterials, materials science, functionlisation strategies, molecular biology, stem cell biology, in vitro model systems, in vivo neuroimaging, animal models and prototype design. Recruited ESRs will receive compulsory discipline-specific, generic and complementary transferable skills training. BrainMatTrain will develop multi-modal collagen reservoir scaffolds incorporating moieties targetitng the neuroinflammatoiry and neuroprotective phases of the underlying pathology of Parkinson’s disease. The researchers will undertake cross-disciplinary and intersectorial research projects, which when married together will deliver a novel, biomaterial-based, therapeutic device for the treatment of Parkinson’s disease. The research training programme is designed to ensure high-calibre graduates, best placed to secure employment in the private or public sector. Fellows will experience both private and public sector research and development environments through a considered secondment plan.

Mots clés : functionalised biomaterials, tissue engineering, scaffolds

Participants :
- Innsbruck Medical University (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255934.08 €
- Lund University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 527318.64 €
- Commissariat à l’énergie atomique et aux énergies alternatives (France) — Partner, beneficiary, Recherche, subvention : 525751.2 €
- Collagen solutions (uk) limited (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 546575.76 €
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1328373.0 €
- Orbsen Therapeutics (Ireland) (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 265674.6 €
- Technical University of Denmark (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 290081.88 €
- Radboud University Nijmegen (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255374.28 €
Projet RTKPalm (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Breast cancer is one of the most diagnosed cancers and the leading cause of cancer death in women worldwide. Breast cancer cells need activated receptor tyrosine kinases (RTKs) to invade, proliferate, and metastasize. Increased activity and overexpression of RTKs is associated with poor prognosis for breast cancer patients. Therefore, multiple RTKs have emerged as attractive therapeutic targets. However, resistance to therapies is a persistent problem for the development of therapeutics targeting RTKs. New and innovative approaches to effectively target these receptors are required. Recently S-palmitoylation has been identified as an important post-translational modification that regulates signal transduction, protein trafficking and degradation of specific RTKs in breast cancer. The substrate scope, role, extent of dysregulation and the enzymes responsible for the S-palmitoylation of specific substrates in breast cancer is largely unknown. In this context, the aim of the proposed project is to implement novel chemical biological tools and methods, to gain insight in the extent, regulation and role of S-palmitoylation of RTKs in breast cancer. This insight will facilitate the identification of new approaches to therapeutically target RTKs in breast cancer.

Mots clés : s palmitoylation, postt ranslational modification, receptor tyrosine kinase, chemoproteomics, cellular genetics, organic synthesis, cancer biology

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet BCSC-ST (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Breast cancer is the most common cause of female cancer death in Europe, hence it is urgent finding alternative treatments. A small population of cells that display stem cell characteristics has been described in breast cancer (BCSC) and linked to tumour progression, resistance to treatment and metastasis. New therapeutic approaches propose the use of stem cell targeting agents in combination with traditional chemotherapy. However, selective targeting of BCSC is still challenging as they are very similar to normal stem cells. Here, I propose to probe two characteristics that may be specific of BCSC: HER2 over-expression and altered protein glycosylation. I will use state-of-the-art technologies including the standardization of a new protocol to isolate Circulating Tumour Cells (CTCs) from blood, and the generation of a library of CRISPRs targeting all the genes related with protein glycosylation. After six years of postdoctoral stage in New York, I have wide experience in RNAi screens valuable for the library development. Supervised by Prof. Elliott at Newcastle University, I aim to learn the insights of protein glycosylation in cancer. The identification of BCSC specific vulnerabilities has important clinical implications as they represent outstanding candidates for new targeted therapies. Importantly, HER2 and protein glycosylation are mainly located in the surface of the cells, being accessible to targeting agents. The accomplishment of the proposal will contribute to my development as an independent researcher since I will: 1) gain knowledge in BCSC and protein glycosylation, fields with multiple functional implications; 2) generate data to use in my future projects, including a list of targeted therapies candidates; 3) standardize a method for isolating CTCs to further study breast cancer metastasis; 4) learn to use CRISPR libraries and generate a library with multiple applications; and 5) be trained and guided in the transition to a full autonomous position.

Mots clés : breast cancer, stem cell, her2, protein glycosylation, crispr screen, circulating tumour cells, therapeutic target

Participants :
- Newcastle University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet MaCaROM (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Breast cancer is the most common form of cancer in women and has a very variable prognosis. Efficacy of anticancer therapies is limited by intertumor and intratumor heterogeneity. To take these into account, tumor models should recapitulate native tumor heterogeneity and should be analysed at the single-cell level. Here, we propose to take advantage of the conserved heterogeneity of breast cancer patient-derived organoids in order to analyze their response to 45 FDA-approved drugs. These responses will be mapped in a single-cell atlas of sensitivities using mass cytometry, and the use of this atlas will be assessed for the prediction of drug sensitivity in future patient tumors and to guide treatment. We plan on exploring the best hits of this screening using imaging mass cytometry to have a spatial view of the evolution of the tumor ecosystem over time after drug treatment. This should positively impact patient treatment and survival and, more broadly, could lead to the new concept of “mapping-based precision medicine”. This project will also uncover the biology of resistance to drug treatments at unprecedented resolution. The study of the different cellular populations composing breast tumors, and their interactions, will lead to a better understanding of the tumor ecosystem and to the identification of therapies targeting specific cellular populations that could trigger tumor demise.

Mots clés : patient derived organoids, mass cytometry

Participants :
- University of Zurich (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet PHENOMENO (Horizon 2020, appel à projets 2020)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : SIGNED

Breast cancer is the most common incident form of cancer among women bellow seventy years of age. Early diagnosis is recognized as a critical factor that improves the chance of survival. In this research, anthropomorphic physical three-dimensional models of the breast are necessary, whenever a real tissue background is required to investigate the detectability of lesions, the performance of image processing algorithms, the reconstruction algorithms, the whole imaging chain and to replace real breast in virtual clinical studies. Manufacturing of such phantoms, however, is still not widely accepted due to cost and challenges of current 3D technology, limited number of suitable printing materials and availability of anthropomorphic computational models. This project aims to form an international network of organizations working on a joint research programme on the development of a complete technology for the production of physical models of the breast based on their computational models. The overall goal is to utilize partners’ experience and expertise to improve research, researcher training and skills and increase knowledge transfer from research to practice, which will be achieved through international and intersectoral collaboration and staff exchange. Expected results are related to new methodology for design of anthropomorphic breast phantoms, new methodology for producing materials and a methodology for development of a prototype of complete equipment and relevant technology for the fabrication of realistic breast phantoms, structures or part of them including health and cancerous tissues. An application in x-ray imaging is targeted. The consortium is with an expertise in rapid prototyping technology, modelling, validating and use of anthropomorphic phantoms, software and hardware design. Joining the efforts of engineers, anatomists, physicists, x-ray imaging specialists in this project will guarantee the successful implementation of the project aims.

Mots clés : anthropomorphic breast models, 3d printing materials, 3d printing technology, breast ct, mammography, phase contrast, dual energy, monte carlo

Participants :
- Microsystems ltd (Bulgarie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 73600.0 €
- Medical University of Varna (Bulgarie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 285200.0 €
- Bioemission technology solutions ike (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 147200.0 €
- Morphe ike (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 156400.0 €
- University of Naples Federico II (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110400.0 €
Projet SCISSORS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Breast cancer is the most common type of cancer in Europe, responsible for the highest women cancer mortalities each year. Characterisation of breast tumours teased them apart to distinct subtypes and facilitated targeted treatments that improved survival rates significantly, yet some aggressive subtypes remain difficult to treat. New therapies that harness the patient own immune system to fight the tumour show remarkable success in several cancers but limited one in breast cancer. Single cell genomics is the cutting-edge method to profile tissues at the highest resolution. As a computational biologist experienced in this technique, I will use it to analyse breast tumours with their residing immune cells. I aim to dissect the dynamic processes that shape the clonal development of the tumour as it emerges from a healthy tissue, with an emphasis on the immune system response to the evolving tumour. Single cell genomics, being the main driving tool, will be leveraged by integration with vast data from thousands of deeply profiled tumour samples available in the Host lab. The project includes generation of a healthy breast single cell expression atlas; a computational method to infer somatic mutations clones from single cell genomics data; single cell profiling of breast tumours together with adjacent normal tissues; and lastly, integration of the results with data from the large tumours biobank that holds years of clinical history which may reveal new progression markers and improve risk stratification. This plan is unique by accounting for multiple aspects of the tumours, including normal to malignant transition, interplay of breast and immune cells, and tumour clonal dynamics. By tackling common cancer immune mechanisms, it may provide novel insights of relevance to all cancer types. Pursuing this grand project in a leading lab that covers all aspects of breast cancer research will increase my research versatility on my way to become an independent researcher.

Mots clés : breast cancer, single cell transcriptomics, comparing tumors and adjacent normal tissue, immunotherapy, dysfunctional t cells, somatic mutation clones, single cell multiomics

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €