Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet OB-VISLY (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Increasing challenges for agricultural production such as climate change, environmental concerns, energy demands, and growing expectations from consumers triggered the necessity for innovation using data-driven approaches such as visual analytics. OB-VISLY extends the visual analytics approach with a structural way of data organization (ontologies), data mining, and visualization techniques to retrieve knowledge from the agricultural monitoring data. The latest advances in data visualization and analytics made it possible to fully exploit the potential of the proposed approach and gain insights into high complexity datasets (multi-source, multi-scale, and different stages). In OB-VISLY, I will carry out state-of-the-art research that unites two strands of recent, significant inquiry: Big Data analytics in the agricultural sector and visual methods. OB-VISLY aims to (1) establish a regionally significant dataspace enabled to synthesize information about fruit-growing apple orchards and vineyards and derive insight from massive, dynamic, and often conflicting data by providing up-to-date, consistent, and credible assessments; (2) create a single visual analytics user interface that can turn the data into knowledge for users of different information retrieval proficiency. OB-VISLY will establish and implement an innovative visual analytics-enabled dataspace within the European agricultural sector. The findings will contribute to European priority in building a digital single market and tackle obstacles that hinder the exploitation of big data and digital tools. Thus OB-VISLY will serve social and environmental well-being by uncovering hidden patterns from big agricultural data for future sustainable and environmentally friendly development. Such an endeavor aims to pave a way towards strengthening precision and conservation agriculture methods and create an added value to sustain under competitive conditions and increase agricultural potential in Europe.

Mots clés : visual analytics, data driven decision systems, ontology, fruit growing agriculture, fair, big data

Participants :
- European Academy of Bolzano (Italie) — Coordinator, beneficiary, Recherche, subvention : 171473.28 €
Projet MALAGA (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Increasing connectivity and automation presents many opportunities and challenges for society. Emerging technology can benefit all citizens with better communication, increased environmental sustainability, autonomous transport, safer roads,, the list is almost inexhaustible. These emerging technologies will disrupt existing business models including underwriting and risk transfer. This disruption can stifle venture capital, innovation and risk taking in key emerging technologies and can inhibit regulatory development and societal acceptance. My research will examine Connected and Autonomous Vehicles (CAV) cybersecurity risks and mitigation using Machine Learning (ML) techniques to predict future risks, price insurance policies and and thereby foster innovation and entrepreneurial activity in Europe. My research will go beyond the SoA and implement models in ML like ensemble models and deep learning to forecast the risks of CAV technology. A network model of interactions will be trained and evaluated to study cascading of risks and threats in the CAV environment. My host team at the University of Limerick have members with machine learning skills, actuarial skills, ethical skills and underwriting experience. I will have access to staff development programmes, training courses, workshops, online courses and internal meetings. My host team are directly connected to a large variety of colleagues in other EU locations in both academic and industry positions. I will work with my host and partners to develop my research and increase my skillsets. My research directly contributes to several UN sustainable development goals. On a personal level, the impact of my fellowship and collaborations will expand my set of skills, both research-related and transferable ones, leading to greatly improved career prospects both in and outside academia. My new abilities will include enhanced machine learning capabilities, cyber risk expertise and risk engineering skills.

Mots clés : autonomous vehicles, cyber security, insurance

Participants :
- University of Limerick (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196590.72 €
Projet HYDIN (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Indium (In) is an element that has recently gained great economic importance due to its application in strategic energy and information technologies. Future In shortages projected by the EC Joint Research Council are due to insufficient exploration for In, reflecting the poor understanding of the hydrothermal ore-forming processes that result in economic enrichment of In. Key questions are the relative importance of different geologically relevant ligands for hydrothermal In complexation, the role of anomalously metal-rich fluids, and the efficiency of different ore-deposition mechanisms for formation of economic deposits. The proposed Marie Curie action will address the hydrothermal transport of In through an integrated approach that links high-temperature experimental studies of the solubility and complexation of In with reconnaissance fluid inclusion studies of In deposits and geochemical modeling of ore-forming processes. The experimental research will combine solubility studies at 100-250°C with hydrothermal diamond-anvil cell experiments up to 600° and synchrotron X-ray spectroscopy. Based on the experimental results, thermodynamic data for the most important In complexes will be derived. The thermodynamic dataset will be used for modeling the control of key fluid parameters such as temperature, pressure and pH on the transport behavior of In in hydrothermal systems. The modeled data will be compared with In concentrations in fluid inclusions from hydrothermal In ore deposits, which will be determined by LA-ICPMS microanalysis. The outcome will be a quantitative understanding of the ore-forming processes that control transport and deposition of In in hydrothermal systems. The researcher will be part of a research network that will bring together scientists from diverse fields of geosciences and physics. This will create an exceptional training environment and will result in optimum transfer of research expertise and knowledge.

Mots clés : indium, rare metals, hydrothermal systems, experimental geochemistry, solubility measurements, hydrothermal diamond anvil cell, synchrotron x ray spectroscopy, fluid inclusions

Participants :
- University of Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 179325.6 €
Projet BT-LH Link (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Individual variations in body size and in behavioural types within a population have, each separately and in isolation, been shown to strongly determine the dynamics and stability of populations and their responses to perturbations and environmental change. However, both aspects of individual trait variation are fundamentally joined by their influence on individual life history traits which ultimately determine population level phenomena through individual growth, maturation, reproduction and survival. Taking this interplay into account can be argued to affect and even reverse predictions of each stand-alone approach. For this reasons, the proposed research project will, using an experimental system with the model species Heterandria formosa that combines individual level and long term population level manipulations, investigate the consequences of and mechanisms behind body size specific, density dependent life history traits linked to behavioural types. Clear hypotheses about total population density, population size structure and dynamics in constant and stochastically variable food environments will help to separate the effects of different sources of individual trait variation and investigate their joint population level effects. After a time of onceptual theorizing, experimental data are now desperately needed to confirm, test and further develop novel ideas and concepts. By integrating two so far isolated approaches (advanced behavioural biology and state-of-the-art population theory) the project will thus contribute to the current paradigm shift in population ecology which is increasingly focusing on the consequences of individual trait variation, helping to formulate a more comprehensive and synthetic theory of population biology.

Mots clés : animal personality, behavioural types, size structure, life history, individual traits

Participants :
- Forschungsverbund Berlin (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 171460.8 €
Projet I-AM-GUT (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal inflammation that has become a global disease with a high economic burden. Adrenomedullin (AM), a hormone associated with gut microbiota and physiology, is naturally present at high concentrations in maternal milk and during lactation. Using a conditional model for AM the fellow identified a protective role of endogenous AM in IBD onset, however relatively little is known about its exact role in early-life, in colitis development or as a potential diagnostic tool for IBD. The fellow hypothesizes that maternal AM’s impact on the breast and gut microbiome may regulate gut and immune development and colitis susceptibility. By creating the first mammary gland conditional knock out for AM, she will uncover novel disease mechanisms and provide the basis for new diagnostic and prevention strategies for IBD. The final goals of this multi-disciplinary project are 1) to unravel the impact of AM on the breast microbiome, the maternal AM influence on healthy infant gut development and the prevention of colitis; 2) to reveal the impact that nutritional intervention and AM administration have on milk and gut microbiome to compensate for dysbiosis and in preventing colitis progression; 3) to evaluate the value of AM as an independent prognostic biomarker for IBD. The project has been carefully designed to match the fellow’s expertise in generating transgenic mice, AM biology and molecular techniques; the expertise of the host institution (APC Microbiome Ireland) in next generation sequencing, cell culture models (organoids), flow cytometry and human studies; and the expertise of the secondment supervisor (UCD) in in situ hybrisation and digital pathology technology. Plans to improve the fellow’s ability to disseminate research findings, gain transferable skills, and learn to manage a project are in place. Ultimately at the end of this fellowship, she will have advanced her position to become an independent researcher.

Mots clés : inflammatory bowel disease, adrenomedullin, microbiota, breast, prognostic biomarker, diet, macrophages, 3d organoids

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184590.72 €
Projet CARBOFLU (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Influenza A virus has two major envelope glycoproteins: HA and neuraminidase (NA). HA binds to sialic acid moieties of glycoconjugates of the host respiratory cells to initiate infection, whereas NA facilitates the release of progeny viruses from infected cells by cleaving sialosides. It is well documented that binding preference is a major determinant of influenza virus host range and avian viruses preferentially bind Neu5Acα(2,3)Gal, whereas human viruses bind Neu5Acα(2,6)Gal. This difference in specificity represents a barrier for transmission of avian viruses into humans. Glycan arrays have been used to assess influenza A virus receptor specificity. However, the currently available glycan arrays contain only a fraction of the glycans found on human airway epithelial cells and cannot uncover glycan binding specificities. Thus, we propose to develop an array that contains glycans representative of the structures found in human airways, since it is a priority in order to understand the biology of influenza virus transmission and pathogenesis. In addition, it has been described that there are two pathways by which influenza virus enters cells. It is believed that some N-glycans serve as attachment factors for concentrating virus particles on the surface of the host cells. However, only specific cell surface proteins modified by appropriate N-glycans can facilitate cell entry. The elucidation of the influenza virus receptor structure will unveil the mechanism at molecular level by which virus enters the cell. To this end, we will develop an experiment, which allows us to identify glycoprotein receptors of flu virus using cell surface glycan editing. The full comprehension of multi-branched glycans, along with the identification of the glycoproteins receptors of influenza virus, will allow the development of new and more efficient glycan-based therapeutics.

Mots clés : carbohydrate, glycosylation, enzymatic synthesis, influenza, glycan microarrays, glycan binding studies, recognition process, virus, protein structure elucidation, protein expression, eznyme kinetics

Participants :
- Utrecht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet ArCarib (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Informal commerce thrived for more than two centuries between the Dutch islands of Aruba, Curaçao, and Bonaire (ABC islands) and Spanish colonial Venezuela, seducing a diversity of regional trans-imperial seafarers and mobilizing vital commodities. Indispensable European ceramics were traded to the mainland chronically neglected by Spanish provisioning fleets, while local Venezuelan ceramics itinerated to the ABC islands to satisfy everyday domestic needs. While much is known about the socioeconomic and political history and impacts of this longstanding commerce, nothing is known of its material dimensions and how the indispensable smuggled ceramics changed or maintained the identities and gender relations of peoples in the colonial societies on the islands and the continent. The central research question of this project is: how did the informal maritime commerce of ceramics in the 17th- and 18th-century South-eastern Caribbean impact the everyday life of communities on the ABC islands and on the Venezuelan coast, particularly their identity formation processes and gender relations? This interdisciplinary historical archaeological project employs my innovative theoretical and methodological framework of assemblages of practice to critically contrast new and existing archaeological, archaeometric, and documentary evidence and answer this central research question. In this first cross-border archaeological study between the ABC islands and Venezuela, I will break new ground revealing how through informal commerce the colonized agentially contributed to the dynamics of continuation and/or change in their communities’ identities and gender relations beyond the restrictive, acculturating, and engendering policies imposed by the colonizer. Through this project I will, therefore, generate completely new knowledge that will advance interdisciplinary understandings of contraband and informal commerce in early-modern colonial contexts and its material dimensions and impacts.

Mots clés : historical archaeology, entanglements, ceramics, identity, gender, informal commerce, contraband, islands, maritime communities, spanish colonialism, inter imperial trade, 17th and 18th century

Participants :
- Pompeu Fabra University (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet INFLED (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Infrared light-emitting diodes (IR-LEDs) serve a broad range of applications including fiber-optic communications, night vision as well as clinical diagnosis and biomedical imaging. Within the family of nanomaterials, colloidal semiconductor quantum dots (QDs) offer exceptional promises for IR-LEDs due to their unique optical properties and low-cost solution-processability. So far, state-of-the-art QD IR-LEDs are based on lead-containing QDs, which has been severely restricted by the environmental directives e.g. EU’s “Restriction of Hazardous Substances” (RoHS). In fact, current challenges of IR-LED technology are to identify and develop novel and efficient lead-free QDs. INFLED aims at demonstrating the first RoHS-compliant and efficient QD IR-LED based on innovative and environmentally friendly material design and device engineering. The project targets the most efficient heavy metal-free infrared QD using a novel synthesis technique as well as rationally nanoengineering at material level. Furthermore, the resultant design at device level will lead to low trap state density, high solid-state quantum efficiency and thereby efficient LEDs. Hence, the key objectives of this proposal are: i) a novel QD synthesis method; ii) material design at nanocrystalline level; iii) LED device engineering at supra-nanocrystalline level. INFLED is at the crossroad of chemistry, physics and engineering, and therefore is expected to attract significant attention from different disciplines along with offering new insights toward next-generation infrared and quantum network technology.

Mots clés : light emitting diode, infrared, quantum dot, nanocrystal, colloidal

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 171473.28 €
Projet TUNING-BRAKES (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Inhibitory control over unwanted thoughts, emotions and movements is essential for effective interaction with our environment. This becomes particularly evident when there is too little inhibition, as in obsessive-compulsive disorder or Tourette’s syndrome, or too much, as in Parkinson’s disease. Recent evidence links successful inhibition to the power of neural oscillations in the beta band (15-30Hz) in a circuit involving the frontal cortex and the subthalamic nucleus. While this is an important step forward, it is not yet sufficient to develop effective neuromodulatory treatments for inhibitory control disorders. For that, we need to understand how the beta oscillations mediate neuronal communication within the fronto-subthalamic circuit. In this proposal, I address this challenging question through novel applications of transcranial alternating current stimulation (tACS). This non-invasive brain stimulation technique aligns neuronal oscillations to an oscillating low-intensity electrical current applied to the brain. This external control over oscillatory power and phase will allow me to investigate: (1) the functional relevance of beta oscillatory phase, and (2) the causal role of interactions between beta oscillations and other frequency bands (‘cross-frequency coupling’). Subsequently, I will develop an innovative, non-invasive, treatment strategy for inhibitory control deficits, by recording and modulating abnormal circuit activity only when present. Maastricht University is the ideal place to perform this research program as it is one of the only institutes in the world that has access to a new generation of deep brain stimulators, enabling concurrent recording of cortical and subthalamic activity, and it houses one of the pioneering groups in using oscillation-based non-invasive brain stimulation. Integration within this multidisciplinary team will offer an exceptional opportunity to increase my skill set, and capability to launch my own research group.

Mots clés : beta oscillations, transcranial alternating current stimulation, cross frequency coupling, inhibitory control, parkinson s disease

Participants :
- Maastricht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet P4 FIT (Horizon 2020, appel à projets 2020)
Action : Doctoral Networks - Joint Doctorates
Panel : Chemistry
Statut du projet : SIGNED

Innovation in tendon medicine is a promising frontier to respond to the urgent societal/economic healthcare demand determined by the worldwide growing incidence of tendinopathy. Perspectives For Future Innovation in Tendon repair (P4 FIT) fosters to build a new generation of 15 early stage researchers with adequate skills to explore non-conventional therapeutic and diagnostic solutions by exploiting the technological advances in nanomedicine. The University of Helsinki brings together world-renowned academic and non-academic EU institutions, covering most of the basic and technological disciplines of the fields to launch a unique EJD. The inter-disciplinary, inter-sectoral, and international high quality educational environment will booster innovation-driving training and research leadership grounded in excellence for widening success in P4 medicine (predictive, preventive, personalized and participatory), promoting tendinopathy resolution. P4 FIT will encourage cross-disciplinary working under the coordination of human and veterinary orthopedics addressing innovation and R&D facilities to combine multidrug nanovectors/nanotheranostic devices with tissue engineering. The translation of innovative nanodevices carried out on integrated pre-clinical and vet/human clinical settings will produce solid evidence-based datasets able to reduce fragmentation still limiting the impact of biomedical discoveries and to offer a unique opportunity for identifying new predictive biomarkers through the use of AI and deep learning data analysis. Working across disciplines and sectors, P4 FIT will foster ESRs to be creative, critical, autonomous intellectual risk takers at the frontiers of research with the R&I mind-set necessary for thriving careers. P4 FIT will allow to fill the EU gap in tendon healthcare, building up a generation of researchers able to develop nano-based biomedical devices by integrating biology advances to technology innovation, and to computational revolution.

Mots clés : nanovectors, nanotheranostics, multidrug delivery, nanoparticles, nanomedicines, tendon regenerative medicine, stem cells, bioactive molecules, immunomodulation, data analysis, biosensors, bioimaging

Participants :
- University of Erlangen-Nuremberg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 758365.2 €
- Keele University (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- Medical University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 528414.48 €
- University of Salerno (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 522999.36 €
- University of Teramo (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 784499.04 €
- University of Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 842417.28 €