Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet GRADIENT (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Long-term historical fire records extending back to the late 1800s are very rare worldwide. Three such long-term historical fire data have been found for this research proposal; (i) Switzerland, central Europe (1900-2014), (ii) Greece, south Europe (1897-2014), and (iii) Algeria, north Africa (1870-2014) which together with the spatial-explicit reconstruction of recent fire history from Landsat satellite images (1984-2016), give a unique and excellent opportunity to understand fire, weather and land use/land cover (LULC) interactions in a north to south transect. Differences in bio-geographical characteristics provided by the three study areas, located on a large geographical gradient covering two continents give the opportunity to document the role of fires in different biomes, to explore cross-scale issues and assess how fire-weather-LULC relationships vary across different scales, especially under a climate change context. This research proposal consists of three topics that correspond mainly to three different scales. The specific objectives are: (i) the identification of trends, patterns and relationships between forest fires, weather, LULC and socio-economic parameters from long-term observations, (ii) the reconstruction of recent fire history and the assessment of burning patterns and fire selectivity on an annual basis from satellite images, and (iii) the exploration of post-fire vegetation dynamics and recovery patterns for selected large fire events using time series satellite images. Those objectives will contribute to the better understanding of fire, weather and land cover interactions, and will therefore provide knowledge for fire and land cover management practices, especially under a climate change context. Understanding of post-fire vegetation dynamics and recovery will help the mitigation of short and long-term consequences of fire occurrence. The knowledge acquired from the past will help to understand current processes and project them to future.

Mots clés : wildland fires, burning patterns, weather, fire selectivity, land cover changes, fire history reconstruction, climate change, time series landsat and modis images, post fire vegetation dynamics

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Recherche, subvention : 117137.25 €
Projet LongActNow (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks - Industrial Doctorates
Panel : Chemistry
Statut du projet : SIGNED

LongActNow will design a novel platform technology for the development of long acting (LA) suspensions of complex active pharmaceutical ingredients (API), involving innovative manipulation of API crystal formation and growth and solvent removal. LA formulations have become a game-changer in terms of bringing existing and new API in more cost-efficient and comfortable ways to patients, often directly impacting commercial viability of new products. However, existing technology platforms are only applicable to a limited part of the pharma portfolio and do not allow to fully unlock all benefits linked to LA. LongActNow is a unique European Industrial Doctorate (EID) initiative that aims to meet the current and future demand for highly skilled scientists and engineers in pharmaceutical development and manufacturing of LA formulations. The initiative is leveraged by fusing the capabilities of four significant international academic and industrial centres (University of Limerick (UL), Trinity College Dublin (TCD), Technische Universität Dortmund (TUD) and Janssen Pharmaceutica (Janssen)) with specific expertise in crystallisation, solution behaviour, modelling, solvent switching, pharmacokinetics and formulation. LongActNow will advance European research in the field of crystallisation technologies, more specifically the design, development and optimization of prediction and production technologies to produce medicines with well controlled physical and pharmacological properties. The project will produce five Early Stage Researchers (ESRs) trained in crystallisation and formulation to a PhD level with a unique capability to optimise the stability and duration of activity of injectable suspensions for complex APIs and will nourish the creativity, entrepreneurship, management and business skills of ESRs in the domain of drug development and manufacturing, to stimulate an innovation-oriented mindset in future pharmaceutical researchers.

Mots clés : crystallization, solvent switching, prolonged release, injectable, suspension

Participants :
- TU Dortmund University (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 505576.8 €
- Janssen (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 512640.0 €
- University of Limerick (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 274684.32 €
Projet MIGPSC (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Looking back to the last 20 years of EU migration management policy, it has become more and more palpable the growth and development of a security industry within a hybrid space, where European and non-European security forces operate alongside NGOs, humanitarian groups and international organizations, and where private security companies play a key role supplying technology, military equipment, hardware and intelligence services. The European Agenda for Migration already reflects the blurring of the lines between internal and external security, with policy outputs echoing the weight of the security industry. This project seeks to understand the increasing role of private security companies and the weight of the security industry in the way the EU migration management policy is shaped and produced. Later advances not only in security field in general, but also in the migration field in particular, illustrate that the market for security is continuously flourishing and a demand market is fed by evolving migration flows. In order to understand the level of influence of private security actors in the design of EU migration policy making, I will use process-tracing methodology to observe the changing pathways of migration policy process and understand when and why this changed has occurred.

Mots clés : migration management, securitization, european border security, private security, surveillance

Participants :
- University of South Wales (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet BCRlossToBWinner (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Loss of B-Cell Receptor (BCR) in lymphoma B cells leads to attenuated PI3K/AKT signaling and altered Myc-dependent transcriptional output, resulting in a competitive disadvantage in BCR-deficient lymphoma cells. The acquisition of genetic events restoring signaling competence is sufficient to improve cellular fitness in BCR-deficient lymphomas. A fraction of Non-Hodgkin-B-cell lymphomas carry missense mutations in FOXO1, a transcription factor essential during B cell development, and a main target of the PI3K/AKT pathway, which relays survival signals downstream of the BCR. In preliminary studies, we found that cells with FOXO1 mutations rewire their signaling status showing a) activation of stress-activated protein kinases (SAPKs) and PI3K/AKT, b) altered responses to key upstream receptors, such as CD40 and BCR, and c) improved fitness. In this context, I propose to investigate whether FOXO1 mutations are able to provide resistance to BCR-loss in transformed B cells, by favoring the activation of PI3K/AKT, SAPK/JNK (and potentially other) signaling pathways. This hypothesis will be tested using mouse and human models that allow conditional deletion of the BCR in FOXO1 mutant B cells, determining whether expression of FOXO1 mutations is: a) sufficient to release normal B cells from BCR-dependency, and b) able to restore competitive fitness to BCR-deficient lymphomas. Moreover, combining CRISPR/Cas9 and chemical screenings, I propose to identify novel factors sustaining the growth of lymphoma cells that lost BCR expression. Overall, this research proposal will address relevant, yet unanswered questions in the biology of B cell lymphomas, providing a better understanding into the complexity of signaling competence in normal and transformed B cells, and identifying novel factors promoting independence from BCR signaling, to be exploited as therapeutic targets for the treatment of B cell lymphomas resistant to BCR-specific inhibitors.

Mots clés : mechanisms of resistance in b cell lymphomas, b cell receptor, foxo1

Participants :
- FIRC Institute of Molecular Oncology (Italie) — Coordinator, beneficiary, Recherche, subvention : 70713.66 €
- University of Ferrara (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 112759.62 €
Projet Polyphemus (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Luis de Góngora’s (1561-1627) two major compositions, Polifemo and Soledades (1613) represent a watershed in the trajectory of Spanish poetics; prompting a polemic over their stylistic innovations that would continue for three centuries. To date there has been suppression of the polemic’s politico-ideological underpinnings and undisputed acceptance that Góngora’s poetry was written to be read by an aristocratic, erudite elite. Consequently research on the reception of his work has been conceptually constrained and confined within the rigid parameters of documents relating to the controversy. The primary aim of this project is to challenge these fundamental assumptions of readership and reception and to propose a new methodological framework which has at its core a confluence of: (a) archival investigation; (b) analysis (qualitative and quantitative) of material evidence with digitalised data presentation; (c) a sophisticated theoretical underpinning that conceptualises literary reception within the wider tensions of socio-cultural self-constitution. The key sustaining hypothesis is that Góngora’s ‘new’ readers were not restricted to the intellectually-renovated receivers anticipated by the poet, but encompassed ‘other’ recipients drawn from a much broader socio-cultural spectrum (archival research carried out by the researcher informs this). Outputs include a journal article, a project website with open-access database, a book-length study and the organisation of an international conference. In line with MSCA objectives the project will enable a transfer of knowledge and interdisciplinary skills of mutual benefit to researcher and host; strengthen the contact networks of both, and enhance the career opportunities of the researcher through international exposure and inter-sectoral mobility. The project will promote collaboration between researchers, archivists and librarians, thus contributing to the recuperation of a significant aspect of Spain’s cultural heritage.-

Mots clés : spanish golden age poetry, readership, reception, literary theory, publishing, rare books, manuscripts

Participants :
- Queen's University Belfast (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet EXCITING-CT (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Lung cancer has the highest incidence and mortality rates of all cancers, and patient survival is strongly linked to early detection. Therefore, low-dose CT screening of high-risk individuals, the only method proven to improve survival, is now recommended by major health organisations. There are, however, concerns with the high rate of false positives and increased radiation exposure associated with screening. We propose to investigate the clinical benefits of spectral CT for lung nodule detection and characterisation. The unique, photon-counting, spectral silicon detector developed by the host group offer twice the resolution, no lower dose limit, reduced artefacts, and higher contrast sensitivity than current state-of-the-art. Our hypothesis is that the patient dose can be significantly reduced in both the detection and characterisation steps, and that the higher resolution will reduce false positives. The reduction in screening dose alone would prevent an estimated 15 cases of induced cancer per 10,000 individuals screened. Fewer false positives would then further reduce the dose through fewer follow-ups and characterisations, lower clinical costs and workload, and reduce patient distress. The fellowship would allow the researcher to benefit from the world-class research, close ties to commercial partners and strong international collaborations of the host, and the exceptional clinical expertise of the partner organisation. In particular, training in cutting-edge detector technology, novel image reconstruction techniques and management of patient studies would complement the researcher’s strong background in medical physics and image analysis. The training, expected high-impact research and networking opportunities will strongly enhance the career prospects of the researcher, the outreach activities will give public awareness of the potential of spectral CT, and the expected clinical gain will benefit society at large, in particular future lung cancer patients.

Mots clés : computed tomography, spectral ct, photon counting, lung cancer, screening, medical imaging, nodule

Participants :
- KTH Royal Institute of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173857.2 €
Projet MACADAMIA (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

MACADAMIA ambitiously seeks a seamless integration of machine learning concepts with physics-based models to optimise aerospace stiffened panels for damage tolerance. As an innovative strategy to delay damage, nanoparticles will be added in failure-prone hot-spots of composite stiffened panels to serve as damage arrest features. The efficacy of machine learning when used in conjunction with advanced computational methods for data classification and prediction will be smartly leveraged to classify and predict damage mechanisms in aircraft structures, the understanding of which is critical to their safe implementation. In aircraft, stiffened composite panels are popular alternatives to structures with mechanical fasteners because they retain strength while reducing weight and part count; but cost and weight savings cannot be fully realized until stiffened panels are certified without fasteners in primary load-bearing structures. It is estimated that a one-pound weight reduction on each aircraft in a commercial fleet would result in fuel savings of 14000 gallons/year, which also mitigates the environmental impact of flight. To strengthen the competitiveness of European aerospace technologies in compliance with evolving environmental regulations, it is vital to work towards accelerated certification of fastener-free composite panels. Major challenges to this goal are: i) damage mechanisms in stiffened panels are complex and coupled, making the evaluation of strength and durability difficult; ii) predictive models for life-cycle estimation have large uncertainty. MACADAMIA envisions an approach with carefully designed experiments for nanoparticle inclusion along with physics-based models to investigate strength and damage evolution in stiffened panels, and machine learning to further optimise them for longer useful life. Multidisciplinary concepts of structural mechanics, computational physics, nanotechnology and machine learning will be used to accomplish research plan.

Mots clés : composite structures, nanomaterials, machine learning, stiffened panels, damage and failure

Participants :
- Delft University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175572.48 €
Projet MARBAL (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

MARBAL will integrate human osteology with isotopic analyses of diet and mobility, osteobiographical reconstructions of the lives of prehistoric individuals, and archaeological analyses of material culture. The project aim is to investigate how Early Bronze Age (2700-2200 BC) mortuary practices shaped, and were shaped by, emerging regional trade networks and the establishment and negotiation of community identities in the Apuseni mountain region of Romania. The research objectives are: 1) To understand the social factors that made individuals eligible for kinds of mortuary treatment, to ascertain whether eligibility for burial was affected by aspects of social identity; 2) To investigate the intersection of social and bioarchaeological inequalities, and 3) To reconstruct community social interactions. These objectives will be achieved by providing training for the EF in 1) osteobiographical and 2) isotopic analyses, while collecting and analyzing osteoarchaeological data from the site of Rameț-Gugului. MARBAL will contribute to our understanding of the ways in which mortuary practices can be used to shape community and individual identities and dampen or enhance living social inequalities. It will take place at the University of Cambridge where relevant scientific, regional and period specialisms abound.

Mots clés : osteoarchaeology, mortuary archaeology, bronze age, metal, social complexity, inequality, romania, europe

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet MEDIPOL (Horizon 2020, appel à projets 2019)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : SIGNED

MEDIPOL (“Molecular Design of Polymers for Biomedical Applications”) is an interdisciplinary, international and intersectoral collaborative effort that utilises the mechanism of personnel exchange between partners located in the EU and Asia to address key aspects of problems of huge international socioeconomic importance. Through carefully planned and integrated secondments MEDIPOL will use knowledge transfer to train 29 ESRs and 20 ERs to be future leaders in both academia and industry. The specific major problems that we shall tackle affect vision and mobility, which are becoming increasingly critical issues in healthcare systems across the world, where the growing socio-economic difficulties of ageing populations are evident at both individual and governmental levels. MEDIPOL is designed to identify, design, develop and disseminate understanding of materials and technologies for systems that will aid and augment the healthy ageing of ocular and dermal tissue. Key to achieving this lies in harnessing the understanding of the moist ocular surface and its relevance to compromised dermal tissue. There are clear links between ocular and dermal sites. Importantly, understanding these analogies facilitates the design of contact lenses especially for use as corneal bandages, of ophthalmic dry eye therapies and of successful burn and wound dressings. These issues are international, they affect quality of life and they are of very significant social and economic importance in both developing and developed economies. MEDIPOL is an integrated 4-year program of knowledge transfer and networking between Aston University, UK (Aston), i+Med S. Coop, Spain (i+Med), Technical University of Liberec, Czech republic (TUL), Chiang Mai University, Thailand (CMU), Naresuan University, Thailand (NU) and Mae Fah Luang, Thailand (MFU). The overarching objective of the proposed joint exchange programme is to establish long-term stable research cooperation between all partners.

Mots clés : biomaterials, polymers, biomedical devices, ophthalmic delivery, wound dressings

Participants :
- Technical University of Liberec (Rép. Tchèque) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110400.0 €
- Naresuan University (Thaïlande) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Mae Fah Luang University (Thaïlande) — Partner, organization partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- I+med s.coop. pequena (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 82800.0 €
- Chiang Mai University (Thaïlande) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1039600.0 €
Projet MEET (Horizon 2020, appel à projets 2018)
Action : European Researchers' Night
Statut du projet : CLOSED

MEETmeTONIGHT (MEET) – “Face to face with the research” is the proposal for the European Researchers’ Night in 2018/19, happening in the two major Italian cities of Milano and Napoli, complemented by Brescia, Castellanza, Cremona, Edolo, Lecco, Lodi, Mantova, Monza, Pavia Sondrio (Lombardia region), Portici and Procida (Campania region). The goal is to realize a special occasion of meeting and interaction between the public at large and the world of research, where researchers – at the forefront of all the proposed activities – can show themselves and what they do, in a simple, spontaneous, informal and entertaining way, actively involving the public. People, by doing, find themselves learning, getting amused, and becoming aware of how much research is for everyone and all around us. All MEET activities aim at promoting research and its outcomes, researchers and their profession, with a special attention to the youngest generations on one side, and to the recognition of the role of Europe on the other. With five thematic areas and five flagship topics, MEET proposes interactive stands, hands-on experiments and live demos that reconstruct the research environment; conferences, video projections, interactive games; guided visits to scientific museums; meeting occasions with researchers; European Corners; live broadcast moments. A special attention is given to schools’ pupils, for which a number of dedicated activities are foreseen, at the goal of encouraging them to consider research career as a concrete option for their life.

Mots clés : responsible research and innovation, public engagement, outreach, interaction, entertainment, citizen science

Participants :
- University of Naples Federico II (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 70000.0 €
- University of Milan (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 70000.0 €
- University of Milano-Bicocca (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 100000.0 €
- Comune di milano (Italie) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 30000.0 €
- Politecnico di Milano (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 90000.0 €