Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MENTHOL (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

This proposal aims to change current paradigms of biotechnological production of complex plant natural compounds, specifically isoprenoids such as limonene, menthol, and p-cymene. MENTHOL main innovation lies in the synthetic decoupling of the complex biosynthetic pathways of these compounds into a distributed catalysis within monoclonal heterogeneous bacterial populations. Limonene and menthol are natural monoterpenes widely used as flavor and fragrance additives, while p-cymene is an important precursor in the bio-based production of terephthalic acid, a key precursor of Polyethylene Terephthalate (PET). Although they have been successfully produced by genetically engineered microorganisms, to reach industrial scale production there are still obstacles to overcome. On the one hand, the introduction of large biosynthetic pathways in a single bacterial strain may cause host unstable physiology and low performance; and on the other hand, the use of synthetic consortia to overcome this shortcoming can be limited by differences in the growth profile of species involved. This proposal is conceived as an alternative to avoid those obstacles, by decoupling the complex biosynthetic pathways of the target compounds into minimal functional modules, to be reassembled inside metabolically differentiated subpopulations of a single specie-based multifunctional bacterial culture. To achieve such ambitious goal, in this project we will applied cutting-edge systems and synthetic biology tools to engineer programmable metabolic heterogeneity inside a monoclonal population of Pseudomonas putida, to promote the division of labor during the production of limonene, menthol, and p-cymene using waste cooking oils as economic and reliable renewable feedstock.

Mots clés : bacterial metabolic heterogeneity, natural compounds biosynthesis, metabolic engineering

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 160932.48 €
Projet CO-CREATION (Horizon 2020, appel à projets 2016)
Action : Staff Exchanges
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This proposal aims to create a structured network for the exchange of knowledge and the joint development of innovative approaches to address a crucial societal challenge of the 21st century, that of the Cohesive City. The project will take a novel approach to urban socio-spatial segregation and territorial stigmatisation, by bringing together academic and non-academic partners in the EU, with scholars in Latin America, to work on a joint international and inter-sectoral research programme. Using an innovative multidisciplinary approach, the scientific objectives of the research are to: • critically review and conceptualise processes of socio-spatial segregation, including urban territorial stigmatisation, from a multi-disciplinary perspective; • develop a new methodological tool, that of ‘Co-Creation’, that brings together researchers, artists and policy-makers to address stigmatisation; • develop policy guidelines and recommendations that can be applied broadly; and • connect the network with a wide audience, both academic and non-academic. To achieve these scientific objectives, the project features a structured programme of knowledge transfer activities, involving secondments, workshops, summer schools as well as communication and dissemination events. The objectives are to: • strengthen and enhance the network of international and inter-sectoral institutions; • mobilise complementary expertise and skills to progress the understanding of mechanisms and processes of urban socio-spatial segregation in different contexts, • provide researchers and practitioners with training opportunities and new insights into different research cultures across countries and sectors. In relation to impact, the research is expected to transform public space, generate new thinking worldwide, promote a unique approach and make a major conceptual and methodological contribution towards a better understanding of the Cohesive City. Its advances will have significant benefits for society.

Mots clés : social cohesion, socio spatial segregation, urban regeneration, citizen engagement

Participants :
- Pontifical Catholic University of Rio de Janeiro (Brésil) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Oxford Brookes University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 135000.0 €
- University of Bath (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 238500.0 €
- Universidad Nacional Autónoma de México (Mexique) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- City mine(d) (Belgique) — Partner, beneficiary, Autres, subvention : 49500.0 €
- Alternatives europeennes (France) — Partner, beneficiary, Autres, subvention : 72000.0 €
- Colini-tripodi gbr (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 63000.0 €
Projet SpeeDrying (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This proposal aims to widen the competences and skills of a young, excellent and ambitious researcher (Loredana Malafronte) by advanced training at one of the most innovative food engineering groups located at ETH - Swiss Federal Institute of Technology Zürich, Switzerland. The training will develop Malafronte's personal, technical and entrepreneurship skills, as well as widen her network of international contacts both in academy and industry. The research project that will be carried out aims to develop a sustainable and innovative spray drying technology for production of highly functional powders from a liquid feed by combining electromagnetic (microwave and/or infrared) and convective heating. The advanced spray-drying technology is expected to improve drying efficiency in food, pharmaceutical and chemical industries, reduce energy consumption, and enable manufacture of flexible dryers and innovative dry products with high functionality. This work will build on knowledge developed by Malafronte during her PhD work and it will give to the candidate possibilities to learn a new scientific approach and how to develop more complex and innovative processes. A tailor processing approach, developed by Prof. Windhab, the main supervisor at ETH, will be used to extract Process-Structure Functions (PSF) and Structure-Property Functions (SPF) from the molecular- to macro-scale during electromagnetically assisted spray-drying. In addition to skills in conducting research, Malafronte will learn how to manage projects, communicate results effectively and commercialize research. This project will give Malafronte the possibilities to pursue a research career in Europe.

Mots clés : spray drying, electromagnetic heating, particle formation, modeling, drying kinetics, encapsulation, powder functionality

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175419.6 €
Projet AMMODIT (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Mathematics
Statut du projet : CLOSED

This proposal brings together research teams from the EU (Germany, Italy, and Austria) and the Ukraine (Kyiv, Donezk) in the area of applied mathematics with emphasis on medical and life science applications. The goal is joint research in six research tasks concerning the study of mathematical methods for Magnetic Particle Imaging; entropy-like measures and quantification of system complexity; coarse-grain modelling for (bio)polymers; diagnostic tools for cardiac surgery; regularization methods for causality detection; meta-learning approach to Nocturnal Hypoglycemia prediction. Each such task will incorporate 24 months of research secondments (18 to the EU, 6 to UA). Four project events (one per year), each including a scientific workshop, a training school and public outreach activities, are planned to be held in the Ukraine involving a total of 27 secondment months. Senior scientists from Ukraine will have 15 secondment months targeted – apart from scientific and management work - at discussing issues how their institutions should develop in a restructuring of the Ukrainian research landscape.

Mots clés : computational mathematics, life sciences, magnetic particle imaging, quantification of complexity, coarse grain modelling of polymers, mass spring approach, regularization method, meta learning

Participants :
- Politecnico di Milano (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274500.0 €
- National Academy of Sciences of Ukraine (Ukraine) — Partner, organization partner, Recherche, subvention : 0.0 €
- Austrian Academy of Sciences (Autriche) — Partner, beneficiary, Recherche, subvention : 283500.0 €
- National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute” (Ukraine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Lübeck (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265500.0 €
- National Academy of Sciences of Ukraine (Ukraine) — Partner, organization partner, Recherche, subvention : 0.0 €
Projet HT PHOTO DB (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This proposal combines synergistically the predictive power of quantum mechanical calculations with a high throughput framework for the accelerated photovoltaic material discovery. The main objective of the project is the creation of a material database that contains no crystalline-complex materials, which can be potential candidate for the development of a new generation of photovoltaic material. The robustness of the project is reinforced by the secondment of Onyx solar which will synthesis and characterize the most promising candidates to validate the methodology and optimize the process. The collaboration between ICCRAM researchers and facilities and the experience of the fellow in this multidisciplinary field guarantee the ideal conditions for the success of the research and the development of new methodologies, infrastructures and knowledge that are highly linked to the roadmap described in Horizon 2020

Mots clés : material database, high throughput, photovoltaic material

Participants :
- University of Burgos (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Universidad de Sevilla (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 158121.6 €
Projet 3DSTAR (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This proposal concerns with the development of functional 3D hierarchical vasculature within engineered freeze-dried collagen scaffolds. The main objective is to investigate the contribution of scaffold’s pore architecture (size, shape and interconnectivity) and culture conditions, such as cell ratios in co-culture, perfusion vs. static culture and hypoxia, on the self-organisation of endothelial cells into vascular-like structures. A comprehensive 2-year, highly inter-disciplinary programme is planned encompassing processing, scaffold structure characterisation, structure-property investigation and systematic in vitro experimentation. The in vitro work will be carried out in collaboration with the REPAIR-lab in Mainz, Germany - a founding member of the European Commission Network of Excellence EXPERTISSUES. Freeze-drying process parameters will be varied to produce isotropic and anisotropic scaffolds, with pore sizes mimicking native small blood vessels. The pore architecture, in both dry and hydrated states, will be quantified via X-ray tomography and 2-photon confocal microscopy, respectively, using original methodologies. The Young’s modulus and resistance to fluid flow (permeability) of scaffolds will be measured as a function of pore architecture characteristics. A customised set-up allowing low strain measurements of Young’s modulus will be used to establish whether conventional mechanical testing is suitable. Fluid permeability will be measured by applying a constant pressure gradient. Rather surprisingly in view of permeability’s significance in nutrient diffusion and waste removal, there is only a single study on permeability. Vascular organization, maturation and functionality of optimised scaffolds will be studied as a function of pore architecture, using state-of-the-art microscopy, real-time imaging, perfusion tests, histology and a variety of biochemical assays.

Mots clés : vascularisation, co culture, porous scaffolds, pore architecture, 3d vascular networks, young s modulus, permeability

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet INNOVATIONOPTIONS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

This proposal consists of a two-year outgoing phase (1.5 years at MIT and 6-month secondment at LUISS U. in Italy) and one-year re-integration phase at King’s College London. Following advanced innovation training, it aims to develop new ideas and frameworks based on real options theory to appraise innovation options and policy flexibility. Besides training/development and dissemination, the proposal will examine two research themes: (1) (First-year at MIT) Analyse flexibility in innovation and public policy under uncertainty. Examine flexible and modular design for robust corporate innovation and public policies to enable dealing proactively with policy risk. Analyse the strategic choice of when to pursue aggressive or exclusionary innovation strategies or cooperate in innovation, depending on market demand, volatility and comparative advantages; (2) (Second-year at MIT and LUISS) (a) Theoretical analysis of how to design optimal and fair licensing terms given who controls development and other options and (b) empirical investigation (secondment at LUISS) of multi-stage R&D and IP licensing deals (viewed as compound real options), applied to a proprietary biotech/pharma licensing deals database. This is of interest to European policymakers and in line with King’s and MIT’s innovation- and policy-oriented strategy connecting research to business and society. During re-integration (Third-year at King’s), an international conference, a public workshop and other outreach and dissemination activities will transfer the knowledge, experiences and insights to the European context.

Mots clés : innovation, real options, intangibles, licensing, strategic use of patents, strategy, technology, management, competition, cooperation, policy

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269857.8 €
- Massachusetts Institute of Technology (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SRoCS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This proposal details an investigation into the development of control software for swarms of robots tasked with building structures. The behavior of the individual robots in this work will be fully autonomous and will be based on the nest building behavior of social insects. It is of interest to investigate whether the building behavior of social insects can be transferred to and implemented in a swarm of robots since the social insect behavior has been shown to be parallel, robust, and scalable. I outline in this proposal the second milestone of my ambitious research project that I have devised to investigate how swarm robotics can be applied to construction. I completed the first milestone of this research project during my doctoral studies, where I implemented and validated a swarm robotics construction system using both hardware and simulation. I have organized the second milestone of my research project into four work packages. In these work packages, I will develop, implement, and validate control software for a swarm of robots, which must perform a construction task. These work packages use a combination of the simulation and hardware tools that I developed during my doctoral studies to efficiently and accurately answer a number of open research questions. I have designed these work packages to be completed at IRIDIA where I have access to world-class facilities such as a computer cluster with more than 1000 CPUs for running simulations and a state-of-the-art arena and tracking setup for running hardware experiments. I believe that by undertaking the second milestone of this project at IRIDIA under the supervision of Prof. Marco Dorigo, I will be able to successfully establish myself as an independent researcher.

Mots clés : swarm robotics

Participants :
- Université Libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166320.0 €
Projet INTENSS (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This proposal envisions a novel framework founded on information-theoretic concepts and mathematical tools for the analysis of embodied and situated systems, including synthetic models based on computer simulations, robotic platforms and biological organisms. The embodied cognition view stresses the importance of bodily interactions with the physical world for grounding concepts and structuring knowledge, underlining the importance of the continuous flow of perceptual information and motor actions. However, the analysis of such systems is still based on frequentist statistic or qualitative descriptions from a dynamical system perspective. The novelty of the proposed approach is the study of such systems from an ecological perspective, constructing a nonlinear and strictly quantitative methodology for behavioural and kinematic studies. The research plan proposes two main scientific innovations. Firstly, the experiments pioneer the application of information theory to human kinematic data to unveil nonlinear functional interactions among several body parts, thus mapping the information structures and causal relationships that characterise the sensorimotor flow. Secondly, the project aims at developing a robust methodology based on an algorithmic application of information-theoretic measures. The initial development of the algorithm is based on systems of coupled equations, defining aprioristically the relationships among variables. Subsequently, the algorithm is refined on neuro-robotics models, which provide a testbed for the validation and further development of the analytical framework by lesioning synapses or locking joints. Finally, the methodology is utilised on datasets recorded from participants to psychological experiments. Findings will be published in relevant scientific journals and the software will be available in an open source format. Moreover, the research program includes actions to reach the general public and the industrial sector.


Participants :
- National Research Council (Italie) — Coordinator, beneficiary, Recherche, subvention : 168277.2 €
Projet ABSREF (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This proposal envisions to foretell the reliability of electronic systems with high degree of accuracy by introducing a novel workload dependent aging aware simulation framework which has acceptable run-time. The framework is generic in nature and will enable one to perform system optimization in presence of multiple aging related phenomena including negative bias temperature instability, positive bias temperature instability, and hot carrier injection. Thus the benefits of the improved timing margin or guard-band incurred by this flow can be leveraged to further improve speed, power, durability of electronic systems and reduce cost. An efficient workload abstraction scheme will be employed which speeds up the transistor level degradation evaluation with accuracy comparable to that of cycle-accurate simulations. Using the device level degradation results, standard cell library characterization will be performed by statistical methods based on Design of Experiments and Response surface Modelling approach. The created workload dependent, aging aware cell libraries will be used to carry out static timing analysis and optimization. Critical path delay degradation evaluated under this framework will be compared with the corner based aging analysis to highlight the impact of the innovation. The framework will be validated using industry standardized, CPU intensive SPEC2006 benchmark suite run on top of multi-core industrial processor. Considering its interdisciplinary nature, the project will help bridge the gap between two disciplines: the device level reliability research and system level interactions. Working in highly international and intersectoral environment of the host IMEC, Dr. Mishra will enhance his professional skills to become a mature independent researcher.

Mots clés : electronic systems reliability modeling

Participants :
- IMEC (Belgique) — Coordinator, beneficiary, Recherche, subvention : 178320.0 €