Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet LUMIMAGNET-NANO (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The key goals of the “LUMIMAGNET-NANO” project are: (a) the training of a talented young researcher, Dr. Rosa Martín-Rodríguez, in the fast growing field of science, technology and industrial applications of nanomedicine, where the host and partner institutions have a critical knowledge and expertise; and, (b) the design, development and optimisation of cost-efficient magnetic nanoparticles with multifunctional recovering for biomedical applications. The aim of the research project is to take advantage of both magnetic and optical properties for magnetic hyperthermia applications. The interdisciplinary training program includes preparation of magnetic nanomaterials, surface modification to provide luminescent functionality, characterization, spectroscopic studies including X-ray absorption spectroscopy in synchrotron radiation facilities, in-vitro study, and implementation for hyperthermia applications. The fellow is a talented researcher who has gained much expertise in synthesis and structural and spectroscopic characterization of luminescent nanomaterials and cell biology protocols during her undergraduate and postgraduate career. To further boost her career, she needs to gain expertise in preparation of biocompatible nanoparticles, magnetic characterization techniques, X-ray absorption spectroscopy and hyperthermia applications, fields in which the University of Basque Country has a world-recognised expertise. Additionally, through two three-month secondments at academic and industrial co-hosts, University of Rome Tre and Resonant Circuits Ltd. respectively, the fellow will gain additional high-level training in X-ray spectroscopy and industrial hyperthermia applications. This multidisciplinary project will also increase her supervision experience, project and intellectual property management expertise, and research funding and proposal writing skills.

Mots clés : synthesis of nanoparticles, structural, magnetic and optical characterization, in vitro studies, x ray absorption spectroscopy at large facilities, magnetic hyperthermia

Participants :
- University of the Basque Country (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 170121.6 €
Projet GLYCONHC (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The key objective of this project is the development of innovative hybrid complexes for oxidative catalysis of pharmaceutically relevant functional groups (e.g. alcohols, amines, olefins), by combining the beneficial properties of triazolylidine N-heterocyclic carbenes and carbohydrates for synergistic catalysis and molecular recognition, ensuring site-specific bind making and breaking processes and tailored delivery. A range of novel carbohydrate-functionalised NHC complexes (e.g. with Ru(II) and Ir(III)) will be synthesised for these purposes and relationships between carbohydrate structure/geometry and catalytic activity probed, complementing experimental approaches with computational insight. NHCs are synthetically versatile and have been demonstrated to have beneficial properties as ligands for catalysis. Triazolylidine NHCs are accessible via modular 'click' chemistry and readiliy functionalised, but not as widely explored as other classes of related compounds. Functionalising carbenes with carbohydrates is practically unknown in the literature despite many advantages such derivatives would possess, including well-defined geometry, rich hydrogen bonding and proton-shuffling interactions, recognition by biological receptors (providing the opportunity for developing NHC-based metalloenzyme mimics through interdisciplinary collaboration) and also chirality (allowing for enantioselectivity). The candidate has synthetic experience matching the project and will benefit from the specific training activities within the host group (who have vast NHC experience), mobility and change of topic to achieve research maturity. Deliverables will include: 1) New catalysts for high-turnover oxidation of pharmaceutically relevant substrates 2) Innovative metalloenzyme mimics based on NHCs embedded in proteins' carbohydrate-receptor sites.

Mots clés : click chemistry, carbenes, carbohydrates, recognition, homogeneous catalysis, weak interactions, catalysis, transition metals, organometallics, triazolylidenes, receptors, peptides, enzyme mimics

Participants :
- University of Bern (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175419.6 €
Projet CYBERSECURITY (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

The key purpose of CYBERSECURITY at the University of Oxford (UOXF or Oxford) is to carry out empirical research to understand the determinants of individual cyber security behaviours of students in France and the UK.

Mots clés : cyber security, cybercrime, cyber security behaviours

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet NanoIP-BioS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The key research goal of the project “Advanced 2D-material integrated photonics technologies for bio sensing (NanoIP-BioS)” is to enhance the leadership and research capability of the Marie Curie Fellow Dr Bing Sun, via implementing a highly challenging and innovative research project focused on the development of high sensitive and selective photonic biosensors by exploring two-dimensional (2D)-nanomaterial, i.e. graphene oxide (GO), black-phosphorus (BP) and MXene, and fibre microsensor structures for applications in food and water safety, environmental monitoring, and healthcare sectors. 2D-material have received significant attentions due to their unique mechanical, electronic, optical and chemical properties. Especially, black-phosphorus and MXene are a new family of 2D transition-metals that are analogous to graphene oxide. Because of their easy availability, hydrophilic behaviour, and tunable chemistry, graphene oxide, black-phosphorus and MXene have been recently explored for environmental pollution remediation such as heavy metal ions detection in water, soil, air and so on. This project will exploit new emerging opportunities with the integration of photonic technologies (fibre gratings, fibre tapers, photonic crystal fibres, fibre lasers) and advanced 2D-material (GO , MXene , BP ) to develop a range of new, highly sensitive, label-free, rapid and promising performance photonic biosensors to address EU and WHO raised issues in water and food safety and general public health care. The Fellow Dr Bing Sun from Nanjing University of Posts and Telecommunications (NUPT), China, will be trained in the fast growing photonics science, technology and application area at the host - Aston Institute of Photonic Technologies (AIPT, supervisor: Prof Lin Zhang, Female), Aston University, UK, with further two EU academic institutes (Aalto University Finland, Valencia University Spain) and two industry companies (Arden Photonics UK and VTT Finland).

Mots clés : photonics technology, optical fibre sensors, 2d material, heavy metal ions detection

Participants :
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet ModernShip Project (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The knowledge of modern naval architecture reached an important stage in the late 80’s with the first characterization of 16th century Ibero-Atlantic shipbuilding drafted by Thomas Oertling. Together with the contribution made by this work to the definition of an architectural model for the ‘Atlantic’ nautical space, it has paved the way for a better understanding of the spatial organization of shipbuilding, where two quite distinct technical cultures coexist, the first called "Atlantic" and the second called "Mediterranean". Over the last 30 years, however, little progress has been made in describing these models, particularly the Mediterranean one, due to a lack of wrecks. The discoveries of the wrecks of Mortella (1527,France) and Santiago de Galicia (1597, Spain), both of Mediterranean shipbuilding tradition, together with the discovery of the probable Mediterranean constructive origin of other wreck dated from the 16th c. (Yarmouth Road, UK) change this situation. The prospect of the analysis of this archaeological data in conjunction with that of the two already documented wrecks of Mediterranean origin (Lomellina and Calvi I, 16th c.) opens the way, for the first time, to the draft of a Mediterranean technical model. By comparing it to the Atlantic model, it also enable a first approach to the technical organization of European shipbuilding as a whole. Therefore, the essential objective of my research project is to contribute to the knowledge of these nautical spaces conceived as "technical spaces" by prioritizing the study of Mediterranean technical culture, still largely unknown, and to characterize it in relation to its Atlantic counterpart. It eventually aims to understand and highlight a shipbuilding system in which these two nautical spaces have been in continuous interaction since the Middle Ages, and to try to comprehend them in all the complexity of their exchanges and technological transfers.

Mots clés : shipbuilding, naval architecture, early modern era, renaissance, mediterranean

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 172932.48 €
Projet NISIHealth (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

The lack of physical activity is a leading cause of preventable death globally. For most people, failure to exercise is unlikely to be due to ignorance or lack of interest. While individuals are frequently motivated to start exercising in order to reduce and reverse different health risks, they often encounter difficulties in forming a sustained behavioral change--a habit. Habits are behaviors repeated in the same setting. They are characterized by activation by recurring context cues, insensitivity to short-term changes in goals, and other markers of automaticity. This action aims: A. to develop information-theoretic measures of regularity and predictability in fitness behavior which can be used as new measures of habits that better predict future retention, B. to understand the role of digital nudges and economic incentives in fitness habit formation and C. to investigate how social influence enhances individual habit formation in the age social media. To assess these research questions, the fellow -- in collaboration with a global exercise tracking company -- will device methodologies currently used in information theory and statistics on large scale historical individual datasets of fitness activity. In addition, the action will make extensive use of surveys and high fidelity randomized control experiments to validate empirical results and establish causal relationships. The complementarity between the expertise of supervision and the fellow’s qualification as well as the arrangements and environment provided by the host institution guarantee the success of this groundbreaking and timely project as well as an effective dissemination and utilization of the expected outcome. The conclusions of the proposed action could have important implications to health agencies in European Union and around the world, and may shape the way public health policy is imposed.

Mots clés : social networks, digital media, human behavior, habits, social influence, nudges, economic incentives, randomized experiments, natural experiments, causality, big data, data analytics, fitness, health

Participants :
- University of Cyprus (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 163648.8 €
Projet LiguSTAR (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The lacus Ligustinus was the great paleo-estuary of ancient Baetis or current Guadalquivir river (Southern Spain). It is a radically transformed landscape because of the intensive sedimentation and other geomorphological dynamics. The estuary banks were highly populated during the Roman period. Important cities and towns articulated the surrounding rural settlement, dedicated to the agricultural and livestock activities. In addition, the lacus allowed the connection with the maritime routes and the output of products destined to foreign markets. Nowadays this spatial configuration is difficult to restore, especially the exploitation villae settlement patterns. The main purpose of the project is to devise a methodology applicable to the study of the paleo-banks through the identification of archaeological sites. In that sense, the right border of the current Lower Guadalquivir region has been selected as a delimited study area, and particularly a local region of Cadiz province. The historical diachronic evolution will be analysed through the archaeological evidences. In order to achieve this, geomorphological, archaeological and other historical data from this area will be integrated in a GIS. Then survey methodology, such as geophysical survey, and UAV flights applications, will be applied in the local scale considering it as a continuum area, to detect archaeological sites employing non-invasive prospection techniques. We will apply this methodology through the selection of a series of study cases. The project will be carried out in the Laboratory of Landscape Archaeology & Remote Sensing (LAP&T) at University of Siena. This laboratory is specialised in survey and integral analysis of ancient landscapes. There the candidate will be trained in the application of these techniques in order to acquire skills for the interpretation of the collected data.

Mots clés : ancient landscape, riparia, roman times, archaeology, gephysical survey, remote sensing, archeology, south spain, baetica province

Participants :
- University of Siena (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet CLAVICHORD (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The last deglaciation (from ~21,000 to 9,000 years ago), during which the huge ice sheets over the North America and Scandinavia melted, is a period of tremendous climate and environmental changes, including Heinrich Stadial 1 (HS1, abrupt cooling over and around the North Atlantic), Bolling Warming (BW) and Younger Dryas Cooling (YD). These changes are documented by physically based paleoenvironmental indicators (such as oxygen or carbon isotopes in ice cores and marine cores), but less by biologically based data (such as paleo-vegetation). Paleo-vegetation data is, however, crucial to document continental-scale climate and environmental changes over the deglaciation. This project aims, for this period of the last deglaciation, at 1) building a comprehensive documentation of climate changes over terrestrial areas from widely available pollen data, 2) assessing the impact of both climate and atmospheric CO2 changes on the vegetation and 3) investigating the changes in large-scale atmosphere circulation and hydrological cycle responsible for these surface climate and vegetation changes. These results will contribute to quantifying the range of possible changes in these circulations in the future. For this purpose we propose to use global pollen data, process-based equilibrium and dynamic vegetation models, and two types of climate models, which can either simulate climate over the whole period but at low resolution, or over specific ~1000 years-long periods, at finer spatial scales. . This project will provide new benchmarking data for understanding environmental changes and evaluating climate models which are used for climate projections. The excellence of the experienced researcher in pollen-based climate reconstruction using process-based vegetation models and paleoclimate simulations from the host institution will ensure the success of this project.


Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 173076.0 €
Projet RightsLab (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The last two decades have seen the EU grappling with a direct conflict of interests; the securitization of its external borders and the demand for a low-cost flexible workforce which in various sectors of the economy, has been increasingly occupied by migrants. Employment of third country nationals (TCNs) through temporary work agencies (TWAs) became a common solution to allow for the smooth supply of workers both in core EU member states, and in Central and Eastern Europe (CEE) region, which is in itself effected by considerable emigration and labour mobility. RightsLab will look into the employment conditions of transnational workers employed through TWAs and ask: how can we develop mechanisms of effective transnational labour rights protection for agency workers? It will provide empirically grounded research into the employment of Ukrainian workers in two CEE countries – Poland and Hungary plus Italy. Both Poland and Hungary, recently has become a laboratory for TWA forms of flexible employment, and Ukrainians represent a large segment of the TCN workers there. Italy – a key destination country for Ukrainian migrants since the late 1990s – offers an important perspective into female employment.The novelty of RightsLab’s contribution is threefold; 1) existing research on the TWAs predominantly focuses on registering labour rights violations: RightsLab makes a step further by exploring the possibilities of creating better mechanisms for cross-border labour rights protection; 2) methodologically, RightsLab combines several qualitative methods, and takes an engaged, participatory stance, actively searching and connecting various participants of the research for a possible social dialogue; 3) by focusing on various levels (national ( labour inspectorates), meso (trade unions, workers’ associations, NGOs) and local (TWAs and workers themselves)) it provides a multidimensional picture of emerging transnational employment regimes and transitional labour struggles.

Mots clés : transnational labour rights, labour mobility, temporary work agencies, solidarity and mobilization, action research, gendered employment and mobility, social meaning of work, worker s agency

Participants :
- University of Padua (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 275209.92 €
Projet PAIR (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The link between physical activity with respiratory health and chronic obstructive pulmonary disease (COPD) remains weak and under-investigated. The limited existing research seems to suggest that systemic inflammation could lie in the causal pathway of this relationship, and that inflammatory-related conditions may modify this potential causal mechanism, although these hypotheses remain largely understudied. This project will investigate 1) the effect of physical activity on lung function decline and COPD incidence in European adults, as well as 2) the mediating role of systemic inflammation and 3) the influence of biological (BMI, co-existing chronic inflammatory diseases), behavioural (diet, smoking) and environmental (air pollution, greenness, ultraviolet radiation) factors on this relationship. Data from over 18,000 subjects from 3 large population-based adult cohorts (ECHRS, SAPALDIA and NFBC), for which data on lung function and physical activity were prospectively collected during at least two follow-ups approximately a decade apart, will be included. Lung function was measured by spirometry according to international standards. Physical activity frequency, duration and type was collected using self-reported (ECRHS and NFBC) or interviewer-administered (SAPALDIA) questionnaires. Systemic inflammation will be assessed using C-reactive protein and interleukin-6 levels in serum. Data on the inflammation-related factors of interest were collected by the cohorts or derived from previous/ongoing collaborations. Cross-sectional and longitudinal associations, and potential interactive effects, will be examined by centre/cohort and combined estimates will be derived. Given that lung function is an important determinant of health and that physical activity is one of a very few prevalent individually-modifiable risk factors, the results of the proposed research have the potential for wide-spread implications as well as public health and economic impacts.

Mots clés : respiratory health, physical activity, inflammation

Participants :
- CERCA Institution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 170121.6 €
Projet KCs and Gut Antigens (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The liver is constantly exposed to intestinal material via portal blood circulation and thus it has long been implicated in the modulation of systemic immune responses to intestinal antigens. Despite this, the precise cells involved and the molecular mechanisms at play are largely unknown. Liver resident macrophages termed Kupffer cells (KCs) are ideally located within the blood stream of the liver sinusoids to encounter intestinal antigens. We hypothesise that KCs acquire intestinal antigens and subsequently modulate the immune response to these. Despite indications that KCs are involved, the lack of KC-specific tools has significantly hampered the study of these cells and to date their physiological role in modulating immune responses to intestinal antigens remains unclear. Here we propose to utilize novel and innovative tools including KC-specific knock-in (KI) mice generated by the host lab to specifically examine the role of KCs in antigen acquisition, presentation and determination of T cell fate. To our knowledge these tools represent the first of their kind and place us in a unique position to specifically examine the role of KCs in regulating the immune response to intestinal antigens. By combining murine modeling with analysis of human tissues in collaboration with the University Hospital, this project will greatly advance our understanding of the role of KCs and potentially uncover new therapeutic strategies in the prevention and/or treatment of disorders where the systemic immune response to intestinal antigens is dysregulated such as food allergies and inflammatory bowel diseases (IBDs).

Mots clés : macrophage, liver, antigen presentation, intestine, kupffer cell, mononuclear phagocytes, t cell, oral tolerance

Participants :
- Vlaams Instituut voor Biotechnologie (Belgique) — Coordinator, beneficiary, Recherche, subvention : 160800.0 €