Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet TEMPER (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Breast cancer is the most commonly occurring cancer in women with over two million new cases reported in 2018. It is a genetically diverse disease with each type requiring different treatment. In developing countries, the highest amount of female cancer deaths are attributed to breast cancer with substantially lower survival rates compared to the western world. Therefore, the aim of this proposal is to develop polymeric drug nanocarriers that can improve drug efficacy, and thereby have potential to make cancer treatment available to all layers of the population including those living in deprived areas. We will develop high affinity nanoparticles that can selectively bind to certain receptors on the surface of cancer cells. When attached, the nanocarriers will release their cargo (drug compounds) specifically to the tumour and thereby improve drug efficacy and subsequently patient outcome. Furthermore, it will reduce adverse effects of common anti-cancer drugs including nausea, fatigue, hepatitis and high vulnerability to endometrial cancer. The drug delivery is usually monitored with optical techniques but the novelty of this project is to use thermal analysis, which is label-free and simple to use. The polymeric nanocarriers are highly versatile and by changing the composition, we can tailor this platform to other drug compounds or other cancer types. In addition, it has high potential as a diagnostic tool in high-throughput drug testing, customization of cellular therapy, and combating bacterial infections. This project could bring tremendous benefits in cancer treatment particularly in developing countries such as India due to its low-cost and simplicity.

Mots clés : targeted drug delivery, biomimetic sensors, thermal analysis

Participants :
- Newcastle University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet ReBounce (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Bridges are key assets of transport networks, a pylon for the society and its economic growth. Hydraulic actions, especially scour are the leading causes of their failure worldwide. Exacerbated by climate change, bridge failures induce fatalities and traffic disruptions with severe economic and societal consequences. To date, the lack of fragility functions and recovery models has prevented the development of a reliable framework for risk and resilience assessment of bridges exposed to hydraulic hazards. As a result, network operators are unable to prioritise restoration and allocate resources objectively and systematically. The ultimate goal of ReBounce is to fill this important capability gap by delivering an integrated framework for the quantification of risk and resilience of flood-critical bridges and the associated transport networks upon which they reside. To this end, the project will deliver for the first time in the international literature: (i) realistic and sufficient flood intensity measures for representative bridge typologies; (ii) rigorous fragility models that will dynamically take into account temporal variations of critical parameters, e.g. scour, debris built-up and ageing; (iii) novel multi-parameter restoration functions that will simulate the effect of restoration tasks on the capacity and functionality of bridges accounting for uncertainties in the idle times and resourcefulness; (iv) test-application of the developed assessment framework on two different road networks in the EU and recommendations for increased system resilience. The proposed research will be carried out by Dr Marianna Loli, under the supervision of Dr S Mitoulis, University of Surrey. Secondments have been agreed with the French Institute of Science and Technology for Transport, Development and Networks and JBA (UK), world-leaders in transport resilience and flood risk management who will provide cutting-edge training to the Fellow and increase the impact of ReBounce.

Mots clés : bridges, hydraulic hazards, scour, vulnerability, fragility models, risk, restoration models, adaptive resilience models, numerical modelling, soil structure interaction, transport network resilience

Participants :
- University of Surrey (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet BGCN (Horizon 2020, appel à projets 2014)
Action : European Researchers' Night
Statut du projet : CLOSED

Bristol’s proposal for the Marie Skłodowska-Curie Researchers’ Night programme takes part across 2014 and 2015. Bristol’s programme for Researchers’ Night has an ambition to involve a wide cross-section of researchers across the city’s two universities centred on the theme ‘Bristol Bright Night’ highlighting the innovative research undertaken by Bristol-based researchers addressing local and global societal challenges. During the Researchers’ Night the city’s waterfront will be transformed into an Innovation Laboratory giving everyone equal access to ground-breaking research, in particular young and family audiences. Bristol has the advantage of having several world-renowned public venues within a short walk of each other in its historical centre. These will host the Researchers’ Night 2014 and 2015. Additionally, in 2015 special opportunities will be provided for celebrating the 10th anniversary of the Researchers’ Night, and the programme will also benefit from Bristol’s designation as European Green Capital in 2015. Bristol’s programme for Researchers’ Night will focus on environmental science and sustainability research conducted locally and through European projects, particularly by Marie Skłodowska-Curie (MSC) fellows, however, Bristol’s digital and creative media cluster will also be involved.

Mots clés : bristol, research, careers, young people

Participants :
- University of Bristol (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 41068.75 €
- University of the West of England (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 44617.5 €
- Bristol Natural History Consortium (Royaume-Uni) — Coordinator, beneficiary, Autres, subvention : 42168.75 €
Projet DECADE (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : CLOSED

Broadband mobile networks are experiencing exponential traffic growth. It is predicted that this trend will continue in the next five to ten years with an estimated compound annual growth rate of 0.6 to 1.0. Hence the traffic (mostly data) carried by a mobile operator’s network in 2022 could be over 1000 times of that in 2012. This traffic growth presents a huge challenge to both the mobile industry and to academic researchers. Along with increased spectrum efficiency, spectrum bandwidth expansion and traffic offloading through WiFi, small cell deployment is regarded as one of the most promising ways to meet the use of broadband mobile service in both outdoor and in particular indoor scenarios in the next decade. The deployment of small cells in a macrocell coverage area leads to a multi-tier heterogeneous network (HetNet), in which a mix of access node types, such as macrocell, femtocell and relay, will co-exist. Despite the current research and development on small cell/HetNet from both industry and academia, there are still many challenges to be addressed and questions to be answered for successful small cell and HetNet deployment. These challenges range from the lack of fundamental understanding of HetNet network capacity to the need of Radio Access Network (RAN) Planning and Optimisation (PO) tool for HetNet deployment involving both indoor and outdoor scenarios. The DECADE project adopts the scheme of Research and Innovation Staff Exchange (RISE), with the effect of inter-sectorial efforts and knowledge integration to tackle the challenges in HetNet planning and optimization. The research consists in fundamental capacity analysis, system modeling, algorithm development, and performance engineering for HetNets. In addition, DECADE serves as a solid platform to promote long-term collaboration between academia and industry collaboration in a rapidly evolving area of Information and Communication Technologies (ICT) in Europe.

Mots clés : heterogeneous networks, mobile broadband, planning and optimisation, small cell

Participants :
- University of Sheffield (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 135000.0 €
- Ranplan wireless network design ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 135000.0 €
- Linköping University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175500.0 €
- Iquadrat (Spain) (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 189000.0 €
Projet BATON (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Brown adipose tissue (BAT) is a highly thermogenic tissue whose main function is to produce heat to maintain mammals’ body temperature. In humans, it has long been believed that BAT is either absent or irrelevant in adults. However, a decade ago, several independent research groups confirmed the presence of metabolically active BAT in human adults. In rodents, BAT plays a key role in the adaptation to overfeeding, protecting murine from diet-induced obesity. Whether this phenomenon also occurs in humans is still unknown. To date, technical limitations for in vivo human BAT assessment have precluded us from adequately studying it. The BATON study will first aim to develop a new method to accurately measure human BAT volume and thermogenic capacity in vivo. New approaches based on recent advances in human BAT metabolism (i.e. BAT’s unique ability to burn its own intracellular triglycerides and the recently discovered, and unexpected, capacity of human BAT to be activated through β2 adrenergic receptor agonism) will be tested in a randomized cross-over study. Ten young healthy adults (18-30 years old, 5 men and 5 women, with a body mass index <25kg/m2) will undergo 3 experimental sessions including sequential positron emission tomography-computerized tomography and magnetic resonance imaging and spectroscopy scans. Later, the newly develop method(s) will be used to measure BAT volume and thermogenic capacity changes in response to a 4-week 40% overfeeding, in a proof-of-concept overfeeding pilot study. Twelve healthy adults (18-30 years old, 6 men and 6 women) with a body mass index <25kg/m2 will participate in this randomized controlled trial. After baseline assessments, participants will be randomized (blocking the randomization by sex) to a 4-week weight maintenance diet (control group) or a 40% overfeeding diet. A 5-days weight maintenance diet will be prescribed before baseline and post-intervention assessment.

Mots clés : human brown adipose tissue, overfeeding, energy expenditure, pet ct

Participants :
- University of Granada (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 250497.6 €
- Université de Sherbrooke (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet BIZPOL (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Business as political actor –evolving practice, emerging norms and shifting expectations for a pivotal determinant of public trust in both business and democracy (BIZPOL) BIZPOL deploys a mix of innovative, multi-disciplinary approaches to substantially advance scholarly thinking, as well as the practical policy debate on corporate political activity (CPA). CPA comprises all non-market activities by companies when they engage with governments and policy-making more broadly to advance their interests. As such, CPA is forcefully becoming central to some of the most vexing societal challenges of our times and evolving into an important area of research in a variety of fields. Business is increasingly recognised as a crucial political actor to address issue such as climate change or corruption. Yet, at the same time, there is a growing public perception in many countries that corporate interests have disproportionate influence over policy-making. This suspicion, real or not, has dramatic consequences for public trust in both democracy and markets. With BIZPOL I aim to make significant contributions to the growing body of scholarship in this area through four interrelated work streams: • what should CPA look like? An exploration of plausible normative expectations for responsible CPA drawing on normative theories of democracy; • what does CPA look like? A comparative diagnostic exercise to assess the transparency and patterns of current CPA practices in major European companies with new metrics and new data; • how is CPA “produced”? A qualitative, in-depth exploration of where and how expectations and decisions about responsible exercise of CPA are constructed and negotiated, inside companies, as well as in the broader stakeholder community; and, • where is CPA heading? A survey and desk-research supported interrogation of the future evolution of CPA and the potential of research and education to critically and constructively accompany this trajectory.

Mots clés : corporate political engagement, business in society, corporate citizenship, lobbying, policy capture, democracy, transparency, corruption, norms, business ethics, corporate social responsibility

Participants :
- Copenhagen Business School (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 328968.0 €
Projet MULTI-LAND (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

By 2030, people aged 65 and over are expected to account for more than 25% of the European population. This fact foreshadows a dramatic growth of aging-related neurodegenerative disorders (NDs), including Alzheimer's and Parkinson's disease. Critically, this scenario will place a severe strain on healthcare systems as NDs incapacitate patients, burden their families, and entail major costs of diagnostics evaluation, including time-consuming neuropsychological batteries and expensive brain scans. Though currently irreplaceable, this approach is often unaffordable and non-viable for remote application -a key requisite during pandemic lockdowns. Thus, these procedures must be complemented with urgent innovations that boost diagnosis and symptom severity detection using low-cost tools applicable to large sections of the population remotely. A promising interdisciplinary framework rooted in natural language markers (NLMs) can offer key solutions to this crisis. This novel framework is based on linguistic features derived from patient's natural speech and analysed via machine learning algorithms. NLMs are characterized by high ecological validity, minimal stress, low costs and adaptability for remote and massive screening. Despite the increasing application of NLMs in the field of mental health, their use in NDs evaluation is still scarce. Building on a unique synergy of international expertise, we will perform the first cross-methodological (behavioural, f/MRI, EEG) and cross-centre (Latin-America and Europe) validation of NLMs in patients with NDs. Specifically, we aim to: (1) establish NLMs diagnostic sensitivity, (2) unveil potential links between NLMs and brain network disruptions, (3) estimate their robustness and generalisation power. The ultimate translational goal of this project is to identify the best-performing set of NLMs to develop a frontline mobile-phone app with clinical value, capable of capturing natural speech features for remote patient evaluation.

Mots clés : neurodegenerative diseases, language markers, cognition, neuroimaging, machine learning, healthy aging

Participants :
- University of San Andrés (Argentine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Basque Center on Cognition, Brain and Language (Espagne) — Coordinator, beneficiary, Recherche, subvention : 224496.96 €
Projet Curiosity Carnival (Horizon 2020, appel à projets 2016)
Action : European Researchers' Night
Statut du projet : CLOSED

By capitalising on the University of Oxford’s world-class European-funded research base, together with our outstanding museums, libraries, gardens and woods, education programmes and public engagement expertise, we will create a truly inspirational multi-venue multi-disciplinary European Research night in 2017 on the theme of ‘People and Planet'. The event itself will be a city-wide programme of high quality and innovative activities utilising both University of Oxford venues in addition to busking-type activities taking place in shopping centre locations. Each venue will have its own ‘flavour’ – focusing on specific research topics and encompassing different activities - so that there will be ‘something for everyone’. By focusing on quantity and quality, we will create a much bigger impact on the audiences and participating researchers and create a long lasting legacy. Objectives: a) Organise an inspirational large-scale public engagement with research event at 8 different venues and locations that engages 10,000+ people via the live activities and 250,000+ via digital and media activities. b) Increase awareness of research and its impact on society to an audience of young people and their influencers. c) Enable at least 200 researchers, including a significant proportion of female researchers, to take part. d) Inspire young people to consider a career in research e) Share our challenges, successes and lessons learnt. Activities will include interactive stalls; games; mass experiments; science ‘demos’; a ‘living library’ for the public to take out a researcher 'on loan' and two grand finales with musical performances. The awareness campaign will facilitate even greater public-researcher engagement across digital and media platforms. This will include a fun and educational online activity for school pupils to interact with researchers. The in-depth impact assessment will utilise baseline data and both quantitative and qualitative methods.

Mots clés : quality, large scale, multi venue, two way engagement, impact, legacy, innovation

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 223152.92 €
Projet DYNACLIM (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

By transporting heat and energy, ocean currents play a major role in shaping the climate of Earth’s many regions. However, characterization of ocean dynamics remains one of the key problems in oceanography. This project addresses the reconstruction of ocean currents from satellite observations. Using two semi-analytical quasi-geostrophic models and proposing a new numerical approach, this proposal aims to exploit the available spatiotemporal sampling capacity of remotely sensed salinity synergistically with sea surface temperature and sea surface high to reconstruct the ocean three-dimensional dynamics. This approach will be applied to the Arctic Ocean and the Mediterranean Sea; two regions of relevant importance in order to better understand the consequences of climate change and where enhanced satellite salinity products are recently being produced. Reinforcing knowledge both on the Mediterranean and Arctic dynamics represent a community priority as they represent key navigation areas, the Mediterranean Sea for its actual navigation transit and the Arctic Ocean if the near future makes ice melting worst predictions a reality and the possibility to navigate through the Northern Pole opens. Moreover, improving the circulation understanding in these areas would also contribute to European politics to reduce the climatic impact of maritime transport contamination.


Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 259398.72 €
Projet CARMEN (Horizon 2020, appel à projets 2020)
Action : Doctoral Networks
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

CARMEN: Communal Art – Reconceptualising Metrical Epigraphy Network will train 11 ESRs to face societal challenges in the fields of intercultural understanding, popular culture, and protection of cultural heritage. Studying poetry in the epigraphic Roman tradition will help to regain an eminent body of European folk art tradition. This fascinating publicly exposed poetry (carmina) combines verbal art forms and material manifestations of cultural expressions for a period of 1000 years. We will edit texts, analyse socialinguistic, aesthetic, and gender topics, and discuss regional phenomena in textual and material culture. Our innovative reconceptualization of this heritage will be an important step to democratise contemporary perceptions of art and to unlock the potential for understanding the heterogeneity of social and cultural performance. Obtaining specialist knowledge on the intriguing CARMEN topic will increase the awareness of cultural diversity and appreciation of popular art. We will take part in the creation of a new community of self-conscious participants in culture-production. Our multidisciplinary and intersectoral program will enable the ESRs to engage in academic research of highest level, as well as in issues of cultural heritage, knowledge transfer and contemporary non-elite culture all over Europe: A perfect match to the overall concept of the ETN-objective of enhancing mobility and employability.

Mots clés : communal art, literary culture, roman empire, latin inscriptions, classical archaeology, intercultural understanding, cultural diversity, democratisation of art perception, decolonialised analysis

Participants :
- University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 264207.24 €
- Sapienza University of Rome (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 522999.36 €
- Generaldirektion Kulturelles Erbe Rheinland-Pfalz (Allemagne) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 252788.4 €
- Johannes Gutenberg University Mainz (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 505576.8 €
- University of Trier (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- Université Marie et Louis Pasteur (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274802.04 €
- Universidad de Sevilla (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 501809.76 €
- University of the Basque Country (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 250904.88 €