Projet StraDiVarious (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Resistance to antibiotic treatment of bacterial infections is a major threat to human health worldwide, with last-resort antibiotics becoming ineffective. Bacteria like carbapenem-resistant Acinetobacter baumannii, Enterobacterales and Pseudomonas aeruginosa head the WHO global pathogen priority list. New strategies are needed to treat AMR bacteria.  Our DN StraDiVarious proposes targeting a key virulence trait: the initial interaction of bacteria with the host. Adhesion is the first and decisive step in infection, mediated by surface proteins called ‘adhesins’, which interact, either directly or indirectly, with the host cell surface to manipulate the host response. Our hypothesis is that we can distinguish between less virulent and more virulent strains of bacteria based on the fine details of their adhesins. This makes the adhesins interesting targets for both diagnostics and therapeutics. The StraDiVarious intersectoral network (including large Pharma and SMEs) will train the next generation of researchers in this important area, focusing on the initial interaction. Our targets include the clinically most relevant pathogens from the “ESKAPE” group (eg. A. baumannii, K. pneumoniae, P. aeruginosa, E. cloacae and S. aureus). The DCs will use state-of-the-art techniques at different levels: infection (tissue/cell), biochemical interactions (cell/molecule), structure (molecule/atom) and timescale (dynamics). We will integrate this information with large clinical strain data (genomics/ proteomics) and use machine-learning to understand the cause of virulence/non-virulence at the level of individual bacterial strains and protein variants. This information will be used not only to develop next-generation strain-specific rapid diagnostics suitable for point-of-care applications but also for finding potential drug/vaccine targets. Such precision medicine will reduce load on the health-care system, avert the antibiotic crisis, and improve patient quality of life.

Mots clés : mass spectrometry nanodevices electrometry

Participants :
- Sonja noss (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université du Minho (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 279445.32 €
- GlaxoSmithKline (United Kingdom) (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Eluceda limited (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 348738.12 €
- Université de Manchester (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 348738.12 €
- Université de Stockholm (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 324630.0 €
- Université de Lund (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 324630.0 €
- Université Johann Wolfgang Goethe de Francfort-sur-le-Main (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 580544.64 €
- Institut Pasteur (France) — Partner, beneficiary, Recherche, subvention : 629338.32 €
- Université Paris Cité (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Oslo (Norvège) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 679864.32 €
- Université d'Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 629049.6 €
- Université Heriot-Watt (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 348738.12 €
- Corticalis (Norway) (Norvège) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Shanx medtech b.v. (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 305285.76 €