Projet PANDORA (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Environment and Geosciences
Statut du projet : CLOSED

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g., iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species. PANDORA’s objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing. PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.

Mots clés : phagocytosis and cellular immunity, infection, immune system evolution, risk prediction

Participants :
- Institut Català de Nanociència i Nanotecnologia (Espagne) — Partner, beneficiary, Recherche, subvention : 247872.96 €
- Cardiff University (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- ALTA (Italy) (Italie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Ljubljana (Slovénie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 234997.56 €
- AvantiCell Science (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 273287.88 €
- University of Tübingen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 249216.48 €
- University of Genoa (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- National Research Council (Italie) — Coordinator, beneficiary, Recherche, subvention : 516122.64 €
- Czech Academy of Sciences (Rép. Tchèque) — Partner, beneficiary, Recherche, subvention : 232422.48 €
- UK Research and Innovation (Royaume-Uni) — Partner, beneficiary, Recherche, subvention : 113869.95 €
- University of Salzburg (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255934.08 €
- UK Centre for Ecology & Hydrology (Royaume-Uni) — Partner, beneficiary, Recherche, subvention : 159417.93 €