Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet EMCOP9CRL (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The components of the Cullin-RING Ligase (CRLs) E3 ubiquitin ligase family play key roles in a wide range of cellular processes including stress response, signal transduction, apoptosis and cell cycle progression, and accordingly, defects in their function and/or regulation are prominent in many pathologies including cancer. The modular CRL architecture is centred upon one of seven different cullin scaffold proteins which associate on one side with a RING protein that acts as receptor for an E2 ligase and, on the opposite side, with a substrate receptor (SR) that confers specificity to the complex. The multiplicity of SRs allows the recognition of many different substrates by the same CRL catalytic core. CRL-mediated ubiquitination modulates the substrate´s biological activity and in many cases targets them for proteasomal degradation. The COP9 signalosome (CSN) complex plays a fundamental role in CRL regulation both by forming stable inhibitory complexes with the CRLs where the E2 ligase and substrate binding sites are occluded, and by enzymatically removing Nedd8 (a homologue of ubiquitin) from the cullin scaffold subunit, in a process termed deneddylation, that leads to inactivation of CRLs. CRL regulation by CSN is still an incompletely understood topic mostly because of the lack of high resolution CSN/CRL structures due to the challenge that the crystallization of multi-protein assemblies of such complexity represents. Fortunately, recent technological developments in another structural technique, cryoelectron microscopy, now allow structure determination of relatively small protein complexes (< 500kDa) to near-atomic resolution. Hence, we propose to use this powerful technique to reveal very high-resolution structures of several different CSN/CRL holocomplexes and shed light on the mechanistic aspects of their function.

Mots clés : cryoelectron microscopy, single particle, image processing, ubiquitin proteasome system, cop9 signalosome, cullin ring ligase

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet TwoCompQuaGas (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The computation of dynamical properties (both equilibrium and non-equilibrium) of interacting quantum systems is one of the foremost challenges in contemporary condensed matter theory. Such computations can describe experiments in cold atomic gases, as well as a diverse range of probes in solid-state systems (e.g., inelastic neutron scattering, ARPES, RIXS). The aim of this proposal is to develop a theoretical framework for the study of dynamical properties of two-component quantum gases (TCQGs), systems that are both ubiquitous and under active experimental investigation. This objective will be achieved in four major steps. 1. Development of a non-perturbative computational algorithm for integrable TCQGs. Exact results from integrability will be combined with efficient numerical routines to evaluate correlation functions. This will enable the study of large systems, beyond the reach of existing techniques. 2. The algorithm will be used to study equilibrium dynamics (spectral functions and dynamical structure factors); results will be compared to predictions from field theory techniques, such as the non-linear Luttinger liquid, and links made to experiments. Analytical study of the attractive gas will examine the role of multiple species of bound states. 3. The non-equilibrium dynamics of TCQGs following a quantum quench will be studied. Numerical results will be combined with analytical insights from the Quench Action framework. Scenarios with no analog in a single-component gas will be accessible, opening a door to new and interesting experimentally accessible physics. 4. A numerical framework to treat non-integrable TCQGs will be developed. Using eigenstates of a proximate integrable point as a computational basis, well-tested numerical techniques such as the truncated conformal space approach and the Chebyshev expansion will perform time-evolution with non-integrable Hamiltonians, enabling direct links to on-going experiments in cold atomic gases.

Mots clés : dynamical properties, non equilibrium dynamics, integrability, bose gas, fermi gas, quantum quench, bethe ansatz, numerical methods

Participants :
- University of Amsterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet SUPEREVOL (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The concept of a supergene, proposed nearly 80 years ago, has become a hot topic in biology. Supergenes are clusters of several loci, each affecting a different morphological or behavioural trait; tight physical linkage and chromosomal inversions suppress recombination so that multiple phenotypic characters are inherited as a single locus. Supergenes play a crucial role in the maintenance of highly discrete adaptive phenotypes, eventually leading to reproductive isolation and speciation. Despite the panoply of complex polymorphisms presumably controlled by supergenes, molecular evidence for their existence is scarce, and the emergence of such genetic architecture is surprisingly poorly understood. The proposed project helps to fill this scientific gap by investigating the supergene that controls shell colour polymorphism in a classical model for ecological genetics and climate-induced evolutionary change, the land snail Cepaea nemoralis. In particular, I will 1) sequence and assemble the genome of C. nemoralis, and 2) identify the individual components of its supergene by linkage mapping in laboratory crosses and association mapping in natural populations. I will do this by taking advantage of the most recent technical breakthroughs in DNA sequencing and bioinformatics. Combining my extensive knowledge of animal coloration with my host laboratory's track record in biodiversity research and genomics, this project offers a unique window into the evolution of supergenes and polymorphisms and provides the European research community with a valuable genomic resource. By uncovering the molecular basis of C. nemoralis supergene I will establish this species as a prominent European model in evolutionary developmental biology. This fellowship will not only allow me to expand my technical and analytical skills, but also enhance my transferable skills, helping me to re-establish myself as a researcher and pave a path through which I will reach professional maturity.

Mots clés : gastropods, shell coloration, polymorphism, genome architecture, genome sequencing, linkage mapping, association mapping, rad sequencing, sequence capture, climate change

Participants :
- Naturalis Biodiversity Center (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 177598.8 €
Projet TexTaConStruct (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The concrete industry is facing major challenges in terms of the global climate crisis as this sector is accountable for 6 to 7 % of global carbon emissions. The proposed research tackles this problem using a multidisciplinary approach with new materials and advanced structural engineering. Textile reinforcement is a novel composite material that allows for a crucial reduction of the embodied CO2 when it comes to designing concrete components. Due to the fact that textile fabrics are made of materials with chemically inert properties, the reinforcement does not need to be excessively protected from environmental impact by concrete cover. In contrast to ordinary steel reinforced concrete (RC)-structures, which often appear massive in shape and execution, with a high wastage of cement that in many cases would not be necessary for the load bearing capacity, textile-reinforced concrete (TRC) allows for a reduction in the required material mass. However, while the form optimization of TRC structures is advantageous in achieving CO2 savings, even greater gains can be realised if the concrete materials within the structural component are also optimized. The fellowship will capitalise on the exciting potential to further decrease the embodied CO2 by functionally grading the concrete in profiled lightweight TRC elements according to the environmental and mechanical conditions the structure is subjected to. The inert characteristics of the textile reinforcement offer new possibilities to incorporate concretes with low amounts of cement clinker whereby the concrete is graded to meet performance objectives while concurrently minimising the carbon intensity. The combination of the extensive expertise of the applicant in the field of textile reinforcement and the fundamental knowledge of the host organisation on functionally graded concrete represents an ideal synergy to realise the fellowship research aspirations for next generation low carbon cementitious structures.

Mots clés : textile reinforced concrete, functionally graded concrete, optimized structure

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 149955.84 €
Projet SKDWONTRACK (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : CLOSED

The constantly increasing energy consumption associated with the functioning of micro-electronic devices calls for the design of more energy efficient technologies. While semiconductor technologies have reached their intrinsic limitations, spintronics offers a new path towards the design of memory and logic devices with high density and low power consumption. However, present spintronic devices such as magnetic-RAMs still suffer from high current density requirements. These drawbacks call for the development of new material systems with intrinsically stable magnetic states, easy to manipulate/detect at a low energy cost. Metallic multilayers hosting chiral spin structures (CSSs) such as magnetic Skyrmions (SKs) and homo-chiral domain walls (DWs) seem to offer a highly promising solution. Their topological stability and outstanding transport properties make them a natural choice for the development of new memory and logic devices. However, much still needs to be learned about their room temperature stabilization, manipulation and detection before being ready for real applications. The project focuses on the investigation of metallic multilayers hosting CSSs using spin polarized-low energy electron microscopy (SP-LEEM) and spin polarized-scanning tunneling microscopy (SP-STM). First, metallic multilayers hosting magnetic SKs and chiral DWs at room temperature will be characterized by SP-LEEM. The dimension, chirality and polarity of the spin structures will be measured. Second, the multilayers containing the most stable SKs and DWs will be patterned into micro-tracks, where the SK and DW motion by spin-orbit torques will be investigated. Third, several electric current/field-based writing, reading and deleting processes of single magnetic SKs will be studied and optimized at the SP-STM. The final goal of the project is to achieve a much better understanding of: CSSs stabilization in metallic multilayers; CSSs manipulation by electric currents and fields.

Mots clés : skyrmion, homo chiral domain wall, dzyaloshinskii moriya interaction, spin orbit torques, spin transfer torque, sp leem, sp stm, magnetic imaging

Participants :
- Universität Hamburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 239860.8 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet CatToSat (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The construction of C-C bonds represents the foundation of synthetic organic chemistry. Specifically, the installation of (sp3)-hybridized carbons is among the most important transformations in an organic chemist’s toolbox due to the prevalence of alkyl-alkyl bonds in organic molecules. Furthermore, compounds featuring a high degree of saturation grant access to greater chemical space and are more likely to yield clinical success in drug discovery and development. The overall aim of the proposed research is to devise new technologies in organic chemistry to access general, modular and applicable C(sp3)-C(sp3) bond-forming reactions, providing high degrees of saturation in organic molecules. Transition metal catalysis will be the foundation for this proposal, in which the most accessible sources for reagents will be used, such as ubiquitous alkyl carboxylic acids and feedstock olefins. In order to accomplish the overarching goal of this research program, the outgoing phase of this fellowship will take place during the first two years in the laboratory of Prof. Phil Baran at Scripps Research, La Jolla, USA. The incoming phase will take place during the final third year in the laboratory of Prof. Bill Morandi at ETH Zürich, Switzerland.

Mots clés : cross coupling chemistry, electrochemistry, single electron transfer

Participants :
- Scripps Research Institute (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260840.64 €
Projet MycoTest (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The contamination of food and feed with harmful fungal derived mycotoxins is a problem worldwide and worsening. Over 400 different mycotoxins are now known, some of them have been studied in great detail, while the data about toxicity and occurrence for many others are scarce. This information is required to determine the risk in relation to animal and human health and establish maximum permitted levels that do not pose any health concerns. The fast elimination of contaminated food and feed from the supply chain is crucial for the protection of human and animal health as many of these toxins can cause serious diseases both after acute and chronic exposure. The occurrence data cannot be provided without fast and reliable detection methods that allow quantification of these toxic contaminants. This research, therefore, is focused on delivering new fast antibody-based (ELISA) screening methods for the detection of three important mycotoxins: T-2/HT-2, ochratoxin A and sterigmatocystin and on the development of a first multiplex flow-through rapid (FTR) test for the simultaneous detection of mycotoxins in food and feed. These tests could be used by food and feed producers, importers and testing laboratories to assure food and feed safety on the European market. The researcher will work for two years with the food safety company EuroProxima (EP) in the Netherlands that will provide training and support of the development of the commercial analytical assays. The project will be also supported by the partner organisations - Institute for Global Food Security (IGFS) at Queen's University Belfast (QUB) and RIKILT Wageningen UR (RIKILT) who will be hosting secondment phases in order to facilitate the work packages. This project aims to combine academic excellence with specialist SME know-how to work on a project with significant impact on public health and that offers a substantial commercial opportunity.

Mots clés : mycotoxins, detection of mycotoxins in food and feed, food safety, human health, immunoassays, elisa, flow through rapid assay

Participants :
- Europroxima bv (Pays-Bas) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 177598.8 €
Projet INCITE (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : CLOSED

The continuous increase of the share of renewable energy sources is redefining the electrical networks. In future infrastructures, an important number of agents (sources, storage devices and consumers) will have intelligent interfaces allowing the regulation of the injection and extraction of power into the grid. This context will create multiple alternatives to increase the efficiency in electricity generation and consumption, to reduce energy costs and to provide a more reliable operation of electrical grids. These future networks will be only possible with suitable control algorithms. INCITE is a multi-sectoral consortium gathering experts on control and power systems, from academia and industry with the purpose of providing innovative control solutions for the future electrical networks.

Mots clés : renewable energy sources, distributed control, optimisation

Participants :
- Université Grenoble Alpes (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 525751.2 €
- General Electric (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 110762.88 €
- 3E (Belgium) (Belgique) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Bologna (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- CERCA Institution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 828640.0 €
- Flemish Institute for Technological Research (Belgique) — Partner, beneficiary, Recherche, subvention : 250560.0 €
- Delft University of Technology (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 766122.84 €
- Efacec (Portugal) (Portugal) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 291787.91 €
- Universitat Politècnica de Catalunya (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 495745.92 €
Projet 4D-Biogel (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The controlled behaviour of biological systems in response to external stimuli is ubiquitous in nature and perceived as a key requirement for the development of advanced functional materials. A good example found in nature is the so-called “sensitive plant” (Mimosa) that responds to touch by rapidly closing its leaves, as a defense mechanisms against herbivores. This quick response to touch is due to rapid water release from specialized cells located at the leaves. In attempt to mimic nature, 4D-BIOGEL project aims to combine new fully biodegradable water-filled hydrogels with additive manufacturing or 3D printing to design smart materials that can undergo a temporal change in their shape under the influence of an external stimulus, giving a 4th dimension to the previously designed 3D object. Light-sensitive structures activated by near-infrared (NIR) are especially appealing, since light can be conveniently pinpointed to the location of interest with the maximum depth of penetration and the minimum damage of tissues. To obtain NIR-sensitive hydrogels, nanoparticles capable of converting light into heat will be incorporated into the hydrogel matrix to afford small volume contraction-expansion changes on demand. This advanced technology offers great potential for the creation of sophisticated dynamic structures with high resolution that could find application not only in regenerative medicine or drug-delivery, but also in robotics or bioelectronics. The 24-month outgoing phase will take place at the University of Washington in Seattle, under the supervision of Dr. Alshakim Nelson - one of the top-class researchers in 3D and 4D printing of hydrogels. The final goal is that during the third year of the fellowship, under the guidance of Dr. Haritz Sardon at the University of the Basque Country in Spain (BERC-POLYMAT), Dr. Eva Sanchez can translate all the expertise acquired about the innovative fields of 3D and 4D bioprinting to Europe, where there is a clear need.

Mots clés : nir sensitive biodegradable hydrogels

Participants :
- University of the Basque Country (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 263732.16 €
- University of Washington (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ProBioMem (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Statut du projet : CLOSED

The core concept of this research project is the development and exploitation of specific molecular probes as innovative tools for monitoring membrane processes in-situ and at molecular level overcoming the limitations of the traditional techniques employed. Project objectives will be achieved through the incorporation, at membrane surface, of molecular probes sensitive to oxygen and able to provide information about the oxygen concentration at the boundary layer related to the growth of biofouling. This will allow to monitor the biofilm onset by monitoring the oxygen change in concentration due to its consumption, when aerobic microorganisms are used, or due to its production, when microalgae are used. In particular, the proposed approach will be very beneficial in such processes where oxygen depletion or production takes place, such as membrane bioreactors (MBRs). The properties exhibited by the smart membranes containing the molecular probes, will allow measuring the oxygen concentration in real time, in-situ, at molecular level and by means of a non-destructive technique. The possibility of knowing a priori the biofouling onset occurring at membrane surface and caused by aerobic microorganisms or microalgae will represent an important breakthrough for the improvement and optimization of the overall membrane process. It will enable, in fact, a precocious intervention steered to mitigate the biofouling formation before the resulting decline of membrane performance.

Mots clés : molecular probes, biofouling, membrane bioreactors, water treatment, smart membranes, molecular sensors, oxygen monitoring, luminophores, polymeric membranes

Participants :
- Universidade Nova de Lisboa (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 147815.04 €