Projet UPsYDe (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks
Panel : Environment and Geosciences
Statut du projet : SIGNED

Yeasts are model organisms for eukaryal cell biology studies but are also used to sustainably produce a large variety of compounds. Although unicellular, death spares no one and yeast can undergo regulated cell death (RCD) in response to a wide variety of intra and extracellular signals. In industrial processes, the occurrence of yeast RCD negatively impacts yields and production rates. How yeast cells die under these conditions is however hardly studied nor understood. UPsYDe aims to decipher how yeast cells die under industrial conditions and engineer RCD pathways to postpone cell death and improve production, while simultaneously training the 13 doctoral candidates needed to tackle this kind of challenges. This requires a synergetic approach combining fundamental cell biology, bioprocess engineering, yeast physiology, and systems and synthetic biology. Four different yeast species, Saccharomyces cerevisiae, Komagataella phaffii, Yarrowia lipolytica and Debaryomyces hansenii, will be studied and engineered in a consortium of 7 beneficiaries and 15 associated partners varying from start-up companies to major biotechnology industries. This consortium offers all the expertise and methodology needed and provides the DCs with a highly diverse, multidisciplinary and intersectorial training plan across Europe. Expected outcomes are novel (rapid) screening techniques to detect cell death phenotypes on site, advanced genome-scale metabolic models, improved yeast strains and more sustainable and profitable yeast bioprocesses. In addition, UPsYDe will deliver the next-generation scientists capable of integrating different knowledge fields to lead the full transition to a sustainable bioeconomy, in academia or industry.

Mots clés : yeast, bioprocess engineering, regulated cell death, metabolic modelling, heterogeneity

Participants :
- Bioingenium sl (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Austrian Centre of Industrial Biotechnology (Austria) (Autriche) — Partner, beneficiary, Recherche, subvention : 605085.84 €
- Universität für Bodenkultur. Vienne (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Octarine bio aps (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Novo Nordisk (Denmark) (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Milan-Bicocca (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281755.08 €
- Université d'État de Campinas (Brésil) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Mycolever gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Wageningen University & Research (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 915857.28 €
- Cambrium gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université technique du Danemark (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 671780.16 €
- Imperial College London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 697476.24 €
- École polytechnique Chalmers (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 324630.0 €
- Acies Bio (Slovenia) (Slovénie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université du Minho (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 558890.64 €
- Université fédérale du Minas Gerais (Brésil) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Koninklijke cooperatie cosun ua (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- DSM (Netherlands) (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Syconium lactic acid gmbh (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Lantana bio (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Lesaffre international (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- International Iberian Nanotechnology Laboratory (Portugal) — Partner, associated partner, Recherche, subvention : 0.0 €
- Aio tech ou (Estonie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €