Projet TAME (Horizon Europe, appel à projets 2022)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

There is an urgent medical need for efficient diagnostics for Alzheimer’s disease and related tauopathies, as well as disease modifying treatments, due to the heavy burden of the disease on patients, families and society. To address this public health issue, TAME R&I training network gathers leading academic and industrial experts in tau research with the ambition to keep older people active and independent for longer. TAME aims to provide better understanding of tau-related diseases and supports the development of new, safer, personalised and more effective diagnosis and interventions for AD and the less common tauopathies. The beneficiaries and partners bring together resources and knowledge across different fields and technologies to provide a multidisciplinary approach necessary to take on the challenge. They have teamed-up to combine molecular and cellular neuroscience with computing, chemical and bio-engineering and their technology expertise. The first tau network of Europe, TAME, will focus on novel approaches using nanobodies, which have emerged as very promising antibody formats in tau research. The primary objective of the TAME is to train 9 fellows to deliver the next generation of talented life scientists. The program will be a combination of training in research, in personal and professional development and in open science, achieved by conducting research projects, attending courses and benefiting from internal mobility within TAME. The research training is based on cutting-edge technologies and advanced models for medical research, emphasizing the need for more human-based research, gender-personalised models and reduction in the use of animals. Consequently, through intense collaboration with all partners and the relevant industrial experience, these 9 fellows can anticipate improved career prospects and higher employability. TAME will provide an innovation-friendly framework in which scientific results can mature and be developed into products.

Mots clés : tauopathies, alzheimer s disease, nanobodies, diagnostics, immunotherapy, imaging

Participants :
- Institut national de la santé et de la recherche médicale (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université libre d'Amsterdam (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Deeplife (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 282693.6 €
- Université Humboldt de Berlin (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Ebrains (Belgique) — Partner, associated partner, Recherche, subvention : 0.0 €
- Adx neurosciences (Belgique) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Göteborg (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 293709.6 €
- Université de Barcelone (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Forschungsverbund Berlin (Allemagne) — Partner, beneficiary, Recherche, subvention : 260539.2 €
- Université de Liège (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262620.0 €
- Motac France (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Neuway pharma gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 282693.6 €
- Instant nanobiosensors co., ltd (Taïwan) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Ligue alzheimer asbl (Belgique) — Partner, associated partner, Autres, subvention : 0.0 €
- Université nationale et capodistrienne d'Athènes (Grèce) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Partner, beneficiary, Recherche, subvention : 251971.2 €
- Hybrigenics services (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 282693.6 €
- Alexander Fleming Biomedical Sciences Research Center (Grèce) — Partner, beneficiary, Recherche, subvention : 240098.4 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 274370.4 €
- Université de Lille (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Paris-Saclay (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €