Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ReGraDe-CS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The project tackles gray debugging of concurrent systems. Gray debugging means debugging systems where only part of the source code is accessible (e.g., the system invokes external services such as Google Maps). Debugging concurrent systems (from multiprocessors to Cloud) is notoriously hard. Reversible Causal-Consistent Debugging and Replay (RCCDR) is an innovative approach to this problem, allowing one to log a faulty execution in production environment and replay it in the debugger. There it can be explored backwards and forwards following causality links from the visible misbehavior to the bug causing it. This approach has been implemented in CauDEr, a debugger for the Erlang language.  Currently, RCCDR requires access to the whole source code of the target program. To enable gray RCCDR we need to answer the following questions:  How can we define RCCDR, and, more generally, reversibility in concurrent systems, in a compositional way, to be able to apply it to systems which are only partially accessible? Are we able to correctly explore backwards and forwards the accessible part? If not, which approximation in the exploration is caused by the missing information about the inaccessible part? Till now RCCDR has only been explored in the concrete setting of Erlang, and gray RCCDR has never been studied. We plan to study gray RCCDR at two levels:  1) the abstract level of event structures. Abstraction ensures simpler proofs and generality of the results, making them applicable to many languages;  2) the concrete level of Erlang semantics, ensuring applicability in a setting of interest, and allowing to implement it by extending CauDEr and integrating it in the Erlang Solutions environment. As an outcome we will provide the theory to apply the powerful RCCDR approach to concurrent systems which are only partially accessible, as well as exploit it in practice, in the setting of Erlang. This will also enable interaction with IT SMEs and software developers.

Mots clés : reversible computing, debugging, concurrency theory, erlang

Participants :
- Huawei Technologies (United Kingdom) (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Bologne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- Université polytechnique de Valence (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Cambridge (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Erlang solutions limited (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet CMCSU (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

What exactly is the epistemic goal of constructing climate models? Can these models help us in our endeavour to understand Earth’s climate system and our role in climate change? This is a very important question that hasn’t yet received the attention it deserves in the recent philosophy of climate science. My overall research objective in this project is to address this important lacuna. I plan to do this by developing an account of climate scientific understanding and the means by which we can achieve understanding in climate science. The method I will use originates with Carnap and has recently gained a great deal of popularity, i.e. conceptual engineering. I will achieve this objective by combining my previous expertise on the topic of understanding with scientific models and the role of mathematics in scientific understanding with the new skills and competencies gained through advanced training, under the guidance of a highly qualified supervisor, Prof. Stephan Hartmann, a leading expert on scientific models and their role in science. Conducting this project at the Munich Center for Mathematical Philosophy (LMU) will considerably improve my research and help me make significant contributions to the current discussion in the philosophy of climate science. This will establish me as an independent research leader in Europe and, therefore, help me secure a permanent academic position. The results of this project can have a wide-ranging impact on the philosophy of science and neighbouring philosophical and scientific disciplines. For instance, it can contribute to a better understanding of the practice of climate science, it can generate a new context for forging interdisciplinary relations between philosophers and climate scientists, and (suitably modified) it can be used in a general strategy to help the general public better understand and trust climate science. My project fits with the 13th goal set out in the UN 2030 Agenda on Sustainable Development

Mots clés : philosophy of climate science general philosophy of science scientific understanding scientific models model understanding scientific explanation model explanation climate models

Participants :
- Université Louis-et-Maximilien de Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet InSilicoPlacenta (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The placenta nourishes the fetus and removes its waste products in pregnancy. Fundamental to its function is the healthy development of an extensively branched tree-like structure known as the vascular tree. In pathological pregnancies, abnormalities have been found in placental structure and function. Impaired uteroplacental blood flow can lead to pregnancy disorders such as fetal growth restriction (FGR), a condition in which the fetus does not grow physiologically. FGR has lifelong consequences for both fetus and mother, affecting 8-10% of pregnancies and contributing to 30% of stillbirths. The placenta is inaccessible to in vivo measurements due to technological and ethical constraints. Ultrasound is the most routinely used clinical imaging tool for screening the placenta; however, it is limited in spatial resolution. Placental function can be also assessed via Magnetic Resonance Imaging (MRI) which is safe during pregnancy; however, MRI models cannot measure blood flow changes in the placental vascular tree. Complementary to imaging, in silico models are increasingly used to probe complex cardiovascular problems. Attempts to model blood flow in the placental vasculature are based on oversimplified assumptions while being limited by the data they have been informed or validated against with. Here, an integrated hemodynamic model of the placental vasculature will be developed using novel ex vivo computed tomography data and computational fluid dynamics. This project will innovate by delivering a computer-based framework, InSilicoPlacenta, which will offer a comprehensive understanding of the structural and functional abnormalities with FGR. We will combine medical imaging with in silico models to infer placental tissue properties of the entire placental vasculature. The long-term impacts of the proposed framework are expected to change clinical diagnosis and management of high-risk pregnancies by reducing stillbirths and improving neonatal outcomes.

Mots clés : medical imaging image based modelling computational fluid dynamics in silico fetal growth restriction

Participants :
- Université d'Australie-Méridionale (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Chypre (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 164328.0 €
- General Electric (United Kingdom) (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet AETHER (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Anxiety-related disorders - such as phobias, PTSD, social anxiety, panic disorder - are highly prevalent and pose a great burden on society. First-line treatment for such disorders is exposure therapy (ET), which entails safely exposing patients to the source of their anxiety. Although current ET protocols are generally effective, many patients do not respond to the therapy or experience residual symptoms and relapses. How to optimize many aspects of ET protocols, such as intensity and timing of the exposures, remains uncertain. Moreover, the current research approach of studying the effect of at most few variables using between-group trials, has produced mixed results, despite large efforts. Finding optimized ET protocols is a high-dimensional search problem, with complexly interacting variables. To efficiently search this high-dimensional space, this action will develop a new paradigm for improving ET by utilizing modern artificial intelligence (AI) and biosignal analysis methods. In particular, the new bio-adaptive ET paradigm will make use of latest advances in reinforcement learning algorithms and psychophysiological models. Reinforcement learning will allow intelligently optimizing the exposure procedure, by sequentially learning from each trial and each participant, and psychophysiological models will allow to estimate the participant's anxiety level better than through overt behavior or physiological signals alone. Although aimed at anxiety disorders, the proposed bio-adaptive ET paradigm has the potential to serve as a blueprint for optimizing behavioral therapies in general. This action will allow the fellow to gain valuable knowledge of latest AI techniques, which will put him at the forefront of the emerging discipline of computational psychiatry. Furthermore, the proposed agenda will lay the foundation for innovative translational research that will ultimately benefit patients in the EU and beyond.

Mots clés : computational psychiatry, anxiety disorders, exposure therapy, extinction learning, associative learning models, psychophysiology, optimal experimental design, reinforcement learning algorithms

Participants :
- Université de Vienne (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 229501.2 €
- Phobius e.u. (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet Metamorphosis (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

In an era of increasing urban vulnerabilities to disasters, this project stands as a beacon of innovation and action. Cities across the globe, including those within the European Union, face increasing number of crises, from climate-driven catastrophes to seismic shocks. These events disrupt economies, societies, and scar the environment, calling for more than just a return to the pre-disaster state; they call for metamorphosis. In "Metamorphosis" project, I will build on the "build back better" principles and develop a framework and tool that would help cities to leap forward by integrating climate adaptation and mitigation, and become not only resilient but also climate neutral. This approach aligns seamlessly with two pivotal EU missions: Climate-Neutral and Smart Cities, and Climate Adaptive Regions by 2030. This inquiry focuses on the Climate City Contract (CCC), a transformative and inclusive governance tool developed by the net-zero research and practice community in the EU. This project aims to evolve it into a Climate Recovery Contract (CRC), one tailored for post-disaster scenarios. The backdrop for this exploration is Ukraine's post-war recovery, offering a unique field to integrate climate transformation into recovery planning. All together, the EU-Ukraine context forms fertile ground for the expansion of knowledge on post-disaster recovery and the crafting of practical instruments like CRC. These endeavors will empower cities not merely to return to their prior states after disasters but to stride forward, embracing climate resilience and net-zero recovery in a collaborative manner, a metamorphosis urgently needed in the face of the global climate emergency.

Mots clés : disasters, recovery, war, participation, orchestration, collective action, governance, ukraine, the eu missions, climate change

Participants :
- Université polytechnique de Valence (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226441.2 €
- KTH Institut royal de technologie (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Stichting climate-kic international foundation (Pays-Bas) — Partner, associated partner, Autres, subvention : 0.0 €
Projet ResolveByBio (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Reactivity studies for organic reactions have so far mainly been done in classical organic solvents (dichloromethane, acetonitrile, DMSO) which need oil or gas as feedstock, are hazardous and cause problems with the waste treatment. Given that almost all organic synthesis protocols need to be revised in a post-oil/gas era, non-toxic sustainable-by-design solvents which are based on renewable, plant-based raw materials will rapidly gain importance. Without reactivity data, however, an informed re-design of organic synthesis is impossible. ResolveByBio will deliver the data for defining the scope of electrophile-nucleophile reactions in biobased solvents, which will be used in the future. EU-located chemical suppliers have recently started to commercialize some of these biobased solvents. Though they have been considered expensive, the steep increase of prices for oil&gas-based chemicals makes them more and more attractive. Once established, scaling effects will make bio-based solvents strong price competitors of conventional solvents. However, these bio-based solvents are still awaiting broader acceptance in academia and commercial chemical applications. Integrating them in the currently most comprehensive reactivity scales (Mayr's Database of Reactivity Parameters) will foster their applications and significantly contribute to reducing the negative impacts of chemistry research and businesses on the environment. Thus, the data generated by the proposed project will deliver important building blocks for the conversion of the EU chemistry towards reaching the goals of the EU Green Deal by empowering chemists with the some of the most fundamental data that are required to change chemical processes.

Mots clés : linear free energy relationships, nucleophiles, electrophiles, reactivity, solvent effects

Participants :
- Université Louis-et-Maximilien de Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet MORFE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Iron (Fe) is an essential micronutrient for the productivity of crops and the quality of their derived products. Fe is also the most deficient mineral nutrient in human diet. Decrypting the molecular mechanisms plants have evolved to acquire Fe from the soil is essential for improving their capacity to absorb and store Fe, which will help to provide adequate dietary Fe to the growing global population. The secretion in the soil of root-borne coumarins has emerged as a key factor affecting Fe uptake in non-grass species. The mechanisms by which Fe mobilizing coumarins biosynthesis, trafficking and secretion is regulated is still not well understood. Using an original bioinformatic pipeline, the candidate has identified conserved DNA-signatures in the promoter of key genes involved in this process in different plants species, including crops. The objective of this project is to identify and characterized in Arabidopsis the regulatory proteins associated with these DNA-signatures and determine their role in plant Fe nutrition. In work package 1 (WP1), the developed bioinformatic pipeline will be further used to enhance the detection accuracy of conserved potential regulatory DNA motifs present in the promoter of Fe-mobilizing coumarin genes. Candidate proteins interacting with the selected potential DNA motifs will be identified using in silico and in vivo approaches (WP2). Last, we will generate mutants in order to precisely define the role of each candidate identified. In vivo imaging of coumarin and candidate protein localization will be conducted to ascertain the role of each candidate in the spatiotemporal distribution of coumarins within the roots (WP3). The proposed project is both feasible and appropriate for a Marie Skłodowska-Curie Individual Fellowship, since the expected outcomes are innovative and will generate knowledge for both fundamental and industrial research, while the candidate will improve his skills and knowledge in a specialized research area.

Mots clés : iron, plant nutrition, specialized metabolites, coumarins, gene expression, transcription factor, cis regulatory sequences, transcriptional regulation, agricultural science

Participants :
- Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (France) — Coordinator, beneficiary, Recherche, subvention : 226420.56 €
Projet YEWHA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Title: Ye wha’? Class, Gender, Race and Age: Fixing Diversity in Text-to-Speech Accessibility Readers Abstract: Ye wha’?* is a creative-critical multidisciplinary project researching normative digital voice and developing alternatives. Research into voices used by chatbots, accessibility programs and text-to-speech readers in English-speaking digital technology shows narrow representation in terms of gender, race, age, class, and regional accent, with most voices presenting as young, white, RP (received pronunciation), and middle/upper class. Prompted by research into the negative impacts of underrepresentation, Ye wha’? will use practice-based research to achieve three outcomes. I will develop an open-source web-based text-to-speech reader app using an alternative range of voices in terms of gender, age, class, race and regional accent, for freely available practical and creative use, in collaboration with my industry secondment partner, Promising Trouble/Careful Industries. I will produce a creative-critical monograph furthering the autotheoretical techniques I have successfully employed in previous award-winning projects, delineating my research, considering issues of representation, and reflecting on voice, technology, and self. Drawing on my previous practical and theoretical investigations into the post-medium and hybrid practice, a key aspect of my project will be to develop, extend and evaluate methodologies that draw together creative research, social interventions, and critical writing. Bringing the fields of art, academia, and social practice into conversation via the creation of a presentation that will allow the exhibition of the app and monograph as an art piece in a range of settings (online, galleries, conferences, festivals, and bookshops) will create a positive interdisciplinary feedback loop as well as ensuring that my project has high cultural, social and academic impact. * Ye Wha’? is an Irish/Dublin colloquialism: “you [said/did] what?

Mots clés : feminist, queer, practice based research, text to speech reader, accessibility, digital arts, digital humanities, anti ageism, gender, class, race, open source, creative critical, autotheory

Participants :
- Université nationale d'Irlande à Maynooth (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
- Careful industries ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet HABITABILITY (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Following a summer where parts of Europe flooded while others burned, this research addresses a fundamentally relevant question: what happens to societies when habitable places become uninhabitable? The large scale effects of anthropogenic climate change are new, but divisions of the world into 'habitable' and 'uninhabitable' regions are not, and have long shaped humanity. My project examines a pivotal part of this longer history by showing how between 1815 and 1914, British and French imperial scientists tried to measure the limits of life on earth in new ways (especially via the new sciences of geology, geography and ecology). There is nevertheless a significant research gap in that previous scholars have generally used intellectual history methods to examine theories of environmental change proposed by elite philosophers based in Europe, rather than addressing the imperial contexts in which this knowledge was made. Bringing an innovative combination of global history and history of science methods to archival sources, my project will close this gap by focusing on Central Asia and Mesopotamia, which became key to investigations into the societal consequences of environmental change (e.g. the movement of the Euphrates river causing cities to be abandoned). Examining the origins of these environmentally determinist imperial categories will simultaneously reveal their problematic legacies today (e.g. the idea of Afghanistan having an inherently 'violent geography'). This research thus aims to place scientific and cultural ideas of 'uninhabitability' into their historical contexts and pioneer 'habitability studies' as an essential interdisciplinary methodology for an age of climate crisis. This will also allow me to enhance my research skills (learning cutting-edge material culture and colonial archive methods) and expand my impact and international profile under the expert mentorship of Prof. Roland Wenzlhuemer to secure an academic position at a European university.

Mots clés : environmental history environmental humanities historical geography

Participants :
- Université Louis-et-Maximilien de Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €