Projet Foie Gras (Horizon 2020, appel à projets 2016)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

FOIE GRAS provides innovative training for 13 early stage researchers (ESRs) to answer two critical and unanswered questions: a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions? and b) Is the disruption of the gut-liver axis involved in NAFLD progression? In Western Societies, there has been a recent surge of non-alcoholic fatty liver disease (NAFLD). Its progression to nonalcoholic steatohepatitis (NASH) is a leading risk factor for development of Type 2 diabetes, cirrhosis, and hepatocellular carcinoma. FOIE GRAS is first in supporting a cohesive and synergistic intersection of complementary and interdisciplinary training skills from academic and non-academic partners. FOIE GRAS combines strong scientific expertise with integrated and complementary training in translational research, clinical practice, technology commercialization, and public outreach, the combination of which in targeting NAFLD is lacking in the EU. Industrial partners CETICS, Mediagnost and Seahorse Biosciences provide experience on technology commercialization alongside scientific contributions while the affiliated patient organization will contribute with important training in societal awareness topics. ESRs training will utilize network-wide workshops and secondments to foster translation of basic research to clinical applications and SME creation. This diverse yet integrated skill set enhances the employment prospects of the trained researchers in both academic and non-academic sectors. Researchers will be endowed with excellent basic scientific knowledge and timely technology transfer know-how for developing novel therapeutic approaches for reversing the burden of NAFLD, thereby advancing both health and economic well-being of European citizens and approaching NAFLD research in the EU from its counterparts in the US and Asia.

Mots clés : fatty liver disease, metabolism, liver, mitochondria, biomarkers, science awareness, communication

Participants :
- Cetics gmbh (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- National Research Council (Italie) — Partner, beneficiary, Recherche, subvention : 516122.64 €
- University of Coimbra (Portugal) — Coordinator, beneficiary, Recherche, subvention : 476712.72 €
- Helmholtz Zentrum München (Allemagne) — Partner, beneficiary, Recherche, subvention : 249216.48 €
- Associacao Protectora dos Diabeticos de Portugal (Portugal) — Partner, organization partner, Recherche, subvention : 0.0 €
- University of Bari Aldo Moro (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 516122.64 €
- Mediagnost gesellschaft fur forschung und herstellung von diagnostika gmbh (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Polish Academy of Sciences (Pologne) — Partner, beneficiary, Recherche, subvention : 224137.44 €
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 262875.6 €
- Czech Academy of Sciences (Rép. Tchèque) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 232422.48 €
- University of Porto (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 238356.36 €
- Seahorse bioscience europe aps (Danemark) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Spanish National Research Council (Espagne) — Partner, beneficiary, Recherche, subvention : 247872.96 €
- University of Lisbon (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 238356.36 €