Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CPR (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The CPR project (A cross-country comparison of Communications designed to Prevent Radicalisation) analyses communications in the UK and Denmark that are designed to contribute to the prevention of vulnerable individuals being radicalised by terrorist groups such as ISIL. CPR will make a significant contribution to a problem facing many European states – namely how to effectively utilise strategic communications to counter terrorist propaganda. It is widely recognised in the literature that, to date, Western states have not been sufficiently effective in their counter-radicalisation communication strategies. It is unclear what a more prioritised communicative approach will mean in practice and communication efforts lack coordination between and, often, within countries to date. By employing an interdisciplinary theoretical approach and utilising unique access to new primary data in both states, CPR will, across four specific research strands, make three major contributions: i) generate a deeper and more nuanced empirical and conceptual understanding of the effectiveness of current counter-terrorism communications targeted at a range of audiences, ii) provide an empirically unique analysis of the challenges to effective prevention communications and, iii) provide empirically substantiated and theoretically informed communications-focused policy requirements that will improve the ability of practitioners and policy-makers to design and deliver communications that contribute to the prevention of radicalisation. CPR will employ a mixed methods methodology, incorporating semi-structured interviews for qualitative analysis alongside online surveys experiments to identify key quantative insights derived from new primary data. The project multi-actor and multi-level analysis in CPR moves beyond the state of the art in terms of methods and theory, access to data, and addressing new and broader questions in an under explored, and empirically lacking, area of research.

Mots clés : counter terrorism, strategic communications, counter narratives, alternative narratives

Participants :
- Aarhus University (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200194.8 €
Projet CRYDIS (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : CLOSED

The CRYDIS exchange programme will establish and support international and inter-sectoral transfer of knowledge and expertise in pharmaceutical and instrument science between several EU research institutes and industrial companies. It will also enhance understanding of the value of inter-sectoral exchange mechanisms for taking research to market. CRYDIS undertakes innovative, collaborative research on the clinically-important topic of dissolution of drug substance particles in bio-relevant media and the undesired subsequent nucleation and re-precipitation of the drug prior to its absorption. Using innovative advances in UV imaging technology, CRYDIS investigates the utility of novel dissolution assays as key tools to obtain fundamental data on the mechanism and kinetics of undesired nucleation and re-precipitation during or following dissolution, a significant problem for the pharmaceutical industry which struggles to obtain sufficient exposure to poorly soluble drug substances to ensure an effective dose is absorbed by the patient. The key technologies in this proposal offer a step change in capability and functionality, offering the potential to undertake more detailed studies of the dissolution/re-precipitation processes relevant to pharmaceutical materials. Access to this key technology and the further development of its capability offers the potential for breakthroughs in development of process understanding and of robust and widely applicable protocols. Additional value is brought to CRYDIS through close working with synergistic European networks, leveraging a greater knowledge input and impact outreach. Running parallel with the science programme, an innovation management work-package analyses effectiveness of the exchange mechanism in building a shared culture, transferring knowledge and developing understanding of processes that drive a product to market. The outcomes of this will be used to advise and drive potential future exchange activities.

Mots clés : combined techniques for enhanced characterization of physical processes  key target materials of pharmaceutical relevance  developing enhanced methods to improve industrial processes

Participants :
- National University of Ireland (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 31500.0 €
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 130500.0 €
- Paraytec (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 18000.0 €
- GlaxoSmithKline (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Pfizer (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 27000.0 €
- Pion inc.(uk) ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 9000.0 €
Projet CellStretch (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The CellStretch project will tackle fundamental questions regarding cardiac arrhythmia mechanisms by leveraging cutting-edge Dielectric Elastomer Actuator (DEA) technology. The development and implementation of a dynamic cell stretching platform using transparent, bio-compatible DEAs is proposed. Novel manufacturing methods of the platform, including the integration of highly stretchable and compliant electrodes, enable the precise control of an applied strain. Attached cells can thereby be mechanically modulated at a well-defined level and rate of stimulation. As the proposed device is transparent, the impact on the cells can be observed using standard optical microscopy protocols in real time. Typically, physiological studies on the cellular and tissue levels are performed in vitro with full control of the experimental environment. A rigid petri dish however, precludes addressing the mechanical degree of freedom. DEAs can transform the static environment of current in-vitro experiments into a dynamically strain-controlled setup. This is not only ideally suited to study the mechanosensitive response of cells, but is also a closer in-vitro approximation to the cells native in-vivo biological environment. The cell stretcher will be used to conduct experiments of mechanical perturbations on cardiomyocytes. Measurements will focus on the impulse propagation velocity and voltage-sensitive die imaging of cell cultures, as a function of externally applied mechanical strain. Such experiments are currently hampered by inadequate apparatus, lacking in speed, flexibility and throughput. The cell stretchers developed promise to enable a host of new experiments on living cells. Studies on cardiomyocytes will demonstrate the strengths of this technology and will be sued to tackle fundamental physiological questions related to arrhythmia mechanisms. In the long term, this can lead to improved treatment for cardiovascular disease, the number one cause of death in the EU.

Mots clés : electromechanically active polymer, dielectric elastomer actuator, cardiomyocytes, cell stretcher, mechanical strain, impulse propagation velocity, patch clamp

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187419.6 €
Projet IPAP (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The Colombian peace process signed in 2016 has shown that even when peace agreements include comprehensive measures to tackle structural inequalities seen as the root causes of the conflict, they may still be rejected by the very societal groups meant to benefit from such transformative provisions. IPAP addresses this dilemma by exploring how peacebuilding institutions can implement a peace agreement that is contested and work to include groups who have engaged in antagonistic actions against the peace accord. The research counters a tendency in the literature to treat resistance against peacebuilding as deviance or abnormality or as a mere manifestation of political and economic elites’ fear of losing power, by including the intersectional politics which explains these groups’ undermining or rejection of the peace process. The objectives of IPAP are: 1) to identify the fabric of antagonistic forces to peace and map their relations with political actors; 2) to examine the intersectional systems of power differentials through which antagonistic subject positions emerge and analyse how they transform into agonistic, i.e. constructively conflictive, relations with the work of peacebuilding institutions; 3) to explore possibilities for peacebuilding institutions to gain sustained legitimacy among the local population; 4) to identify ways in which peace institutions might engage with difference and create spaces where adversaries can engage in agonistic dialogue. To achieve these objectives, IPAP uses a feminist intersectional lens to peacebuilding, and an ethnographic fieldwork approach, to empirically study Colombia as a rich case of antagonism to peacebuilding. The innovative approach of IPAP consists in advancing the notion of antagonistic subject positions to peace to identify the intersecting relations of power through which groups of population who resist peacebuilding processes are organized and how they can commit to agonistic dialogue.

Mots clés : feminist intersectionality, post conflict transition, colombia, agonistic pluralism

Participants :
- Aberystwyth University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet CoopClickCat (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The CoopClickCat project features Cooperatively operating Click-derived ruthenium Catalysts for the efficient oxidation of organic and inorganic substrates with high rates and turnover numbers. For this purpose, triazolylidene ligands, which are readily available through click-chemistry, will be functionalized with a cooperative donor site for improving the catalytic activity of the bound ruthenium center. The ligand design involves a sterically constraint position of the donor site, thus preventing this group from coordination to the metal center. The availability of a Lewis acid (ruthenium center) and base in a confined arrangement will enable the two sites to act cooperatively, thus providing access to concerted proton and electron transfer processes. This synergistic behavior lowers activation barriers and hence leads to a smoother potential energy surface for reduction and oxidation reactions. This unique arrangement will lead to new oxidative coupling processes and reduction pathways for the activation of abundant starting materials such as alcohols and amines, and eventually also water to reach unprecedented activity in ruthenium-catalyzed water oxidation catalysis. This project efficiently combines expertise of the researcher (Dr. Marta Valencia; hydride chemistry, alcohol oxidation) with core competences of the host lab (Professor Martin Albrecht, University College Dublin; triazolylidene chemistry, water oxidation).

Mots clés : click chemistry, mesoionic carbenes, ligand cooperativity, alcohol deshidrogenation, amine deshidrogenation, water oxidation

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet UNITE (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The Court of Justice of the European Union (‘CJEU’) has strongly contributed to the European Union (’EU’) as we know it today, through enlarging the competence base of the EU through its case-law. However, the current challenges that the EU polity faces, ranging from consecutive waves of enlargement, financial bail-outs, and waves of immigration, suggests that the EU may not need integration anymore, but unification. It may require an EU citizenry that is united in solidarity and willing to organize itself collectively, through forms of self-government. In the existing EU constitutional scholarship, judges are assumed to be able contribute to a unified citizenry by two major means. One the one side of the debate stand those conceptualization courts as ‘legal-interpretative’ agents that can strengthen forms of self-government if they interpret the law on the basis of distinct hermeneutical theories of legal interpretation representing the will of the citizens. On the other side of debate stand those conceptualization courts as ‘political-constitutional’ agents that can speak with the voice of the citizenry if they fulfill certain institutional conditions that allow citizens to participate in court decision. UNITE aims to explore new means through which the CJEU could, through its case-law, contribute to the unification of the EU citizenry and flourishing forms of EU self-government through conceptualization it as ‘cultural-moral’ agent. More specifically, UNITE is grounded in the assumption that the judicial opinion is a cultural artifact, which can, through the cultural narrative it is grounded on, give expression to and alter how citizens think about themselves and the community they inhabit. The project aims to reveal the shape and form of such cultural narratives through suggesting the use of political philosophy as analytical tool.

Mots clés : court of justice of the european union, eu constitutional law, self government, qualitative methodologies

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 207312.0 €
Projet mcMINFLUX (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The DNA contained in each of our cells has a size of about 2 m and is fitted into the nucleus which is about six orders of magnitude smaller. It is unclear, how this extraordinary compaction is achieved and how the cell can still carry out highly regulated processes like gene expression, DNA replication, and DNA repair in such a dense environment. Cohesin is a protein that has been shown to play an important part in DNA compaction, especially in sister-chromatid cohesion. Recently, it has been observed that cohesin extrudes loops of DNA to achieve compaction, but how exactly it carries out its function is unknown. Fluorescence spectroscopy is a powerful tool to investigate conformational dynamics of biomolecules. MINFLUX is a recently developed method which localizes single molecules with a precision of a few nanometers. Here, I propose a new method based on MINFLUX which will allow to track fluorescent labels on large bio-molecular complexes with nanometer spatial and millisecond time resolution. The method will be used to study conformational dynamics of cohesin in vitro and investigate the mechanism of loop extrusion.


Participants :
- Research Institute of Molecular Pathology (Autriche) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 186167.04 €
Projet E-SCENT (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The E-SCENT project aims to develop wearable chemo-responsive sensor arrays for personal monitoring of exposure to volatile airborne pollutants. Indoor levels of volatile organic compounds (VOCs) can be up to 1000 times higher than background outdoor levels, and can have serious harmful health effects. Measurement of exposure to airborne pollutants at the individual level is an integral part of human health risk assessment, but is currently reliant on macro-level air quality data and lacks the necessary tools for monitoring at the individual level. A number of personal environmental monitoring devices have recently emerged, but are constrained to sensing physical parameters. E-SCENT will advance personal environmental sensor technology by developing the first personal chemical environmental monitoring tool comprising an array of cross-responsive materials for colourimetric detection of VOCs in a wearable epidermal patch format to enable seamless collection of multi-parameter exposure data at the individual level. A diverse range of chemo-responsive dyes will be incorporated in porous matrices for deposition and encapsulation on stretchable conformable films suitable for integration with the epidermis. Sensor protypes will be developed and their deployment in a variety of indoor environments will enable chemical fingerprinting of ambient VOCs. Sensor colour change upon exposure will be quantitatively measured using smart phone image capture technology with image analysis software to examine sensor colour space and changes. Chemometric analysis of multidimensional colourimetric data will be used for classification of VOC exposure levels. E-SCENT will enable rapid low-cost data generation that will advance air quality research and will prove to be a key technology in informing exposure assessment, related health impacts and counter measures by informing policy development at local and European levels.

Mots clés : volatile organic compounds, indoor air quality, chemical sensors, image analysis, chemometrics

Participants :
- Dublin City University (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet Degrees of Belief (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The ER (Edward Elliott) is an early career researcher. The focus of his research to this point has been the philosophy of mind (particularly issues relating to mental representation) and the mathematical foundations of decision theory. The research goal of the project is to develop a novel account of the nature of degrees of belief (explained below), which is capable of accommodating what we have learnt empirically about ordinary agents’ probabilistic reasoning and decision-making processes in recent decades. This project builds on the ER’s existing research expertise, but with the support of the host institution (University of Leeds) and the supervisor (Professor Robert Williams), the scope of his work will be extended into new areas. Engagement in these areas will progress the ER’s career and forge connections to the European philosophical community. By drawing together issues from the philosophy of mind and formal epistemology/decision theory with an eye to the empirical work relevant to these areas, this project will help to establish the ER’s position at the cutting edge of contemporary discussion. The research goal of the project is to develop a novel account of the nature and representational content of the degrees of belief of ordinary, non-ideal human beings. Specifically, the project will draw on recent work on the formal foundations of decision theory, as well as recent empirical evidence regarding decision-making and probabilistic reasoning, for the development and defense of a broadly functionalist account of degrees of belief. The account will centrally involve a novel perspective on the nature of degrees of belief and the relationships that hold between different kinds of degrees of belief. A centerpiece of the account will be a new decision-theoretic representation theorem (a mathematical proof that any subject satisfying certain conditions can be represented as if she has such-and-such degrees of belief).

Mots clés : degrees of belief, credences, representation theorem, functionalism, mental representation

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet SCIENCE CASTLE (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

The ERN event is organised in a physical space - a castle where different areas ensure multiple discovery paths to the visitors. The visitors (grouped in one of four categories: families, schools, citizens and researchers) start their journey in the main gate (reception area) where they receive a conquer map which allows them to start their participatory journey through the science castle. From this starting point, visitors can use a map (programme) with suggested tours adjusted to their profile (category) or they can choose their own paths. The journeys (whether recommended or personalised by the visitors) are built on the castle map. Each area represents a research and innovation priority defined in Horizon Europe and has supporters and key-players of that research and innovation area.

Mots clés : science, citizens, research, innovation, night, edutainment

Participants :
- Reachingline unipessoal lda (Portugal) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 74752.5 €
Projet ERoDES (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The ERoDES research project aims, for the first-time, to develop our ability to understand, anticipate, and make projections on how coastal dunes would respond to future extreme storms and sea level rise along the Atlantic coast of Europe. As climate change is expected to cause more intense extreme weather events and an increase in extreme sea levels along the coastline of Europe and other continents, it is crucial to understand coastal dunes behaviour, since they serve as the first line of protection against coastal erosion and flooding. Field observations, a process-based and a reduced-complexity model will be used to hindcast and forecast dune behaviour at highly diverse coastal environments under previous and future sea level rise and extreme storms scenarios. These results will provide useful information and tools for short-and long-term coastal management strategies along the Atlantic coast of Europe. The researcher has demonstrated over the last few years a strong knowledge and understanding of geomorphological and hydrodynamic processes along diverse coastal environments, and aims to develop his numerical modelling skills through this project, benefiting from the strong experience of the supervisor. Knowledge exchange between the researcher and the host will offer the opportunity to explore niche topic such as the use of Satellite data, and to analyse outstanding but yet unexploited LiDAR datasets. The various achievements of this multidisciplinary project will be disseminated to both academic and non-academic key actors of coastal science and coastal management, adding social and economic repercussions to the scientific impact of the ERoDES project. Communication activities such as a scientific field trip, a science festival, and the presentation of new technologies used in coastal science like drones, will also be organised with the wider public to illustrate how EU-funded research aims to contribute in reducing risk in coastal flooding and erosion.

Mots clés : geomorphology, coastal erosion, coastal dunes

Participants :
- Université de Bordeaux (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 277061.76 €