Projet HUMAN (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Metabolomics provides a real-time view of the metabolic state of the examined samples. The past decade the field showed strong growth, however limitations intrinsic to the field hinder further application in epidemiology level. Key obstacles include: variety of analyte molecular structures, slow marker identification, large differences in concentrations, poor validation, incomplete combination of data from different analyses and fragmentation of research. The consortium brings together scientists from different complementary disciplines and sectors to collaborate and set a research training network, combining infrastructure experience, knowledge and skills. The research scope is to identify the source of problems that hinder development, and recommend measures to overcome these. Training through research will promote a new generation of omics researchers. Networking, joining forces via secondments will enhance research productivity transfer of knowledge. The project will train 10 ESRs in work-packages aiming toward improvement of design of experiment, harmonization of analytical methods, improved Data Mining and biochemical pathway analysis and translational research. Application will be in the study of blood metabolome of exhaustive physical exercise. We aim to study sample stability & preparation (including blood and alternative forms such as dried blood spots), biomarker identification, exploitation of multiple datasets, promote standard procedures, develop robust pipelines, develop and implement machine searchable notations of metadata, central database for data storage, compare datasets, automate cross-laboratory data combination, develop novel algorithms for multidimensional data mining and reconstruct biochemical pathways. The overall goal is to train the ESRs in cutting edge metabolomics research and at the same time provide proof of concept of democratizing metabolomics by the use of patient centric sampling.

Mots clés : lc ms, blood, dried blood spots, metabolic profiling, biomarker discovery, annotation, identification, statistical analysis, 

Participants :
- Imperial College London (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centro de Estudios Universitarios (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 251971.2 €
- Institut national de recherche pour l'agriculture, l'alimentation et l'environnement (France) — Partner, beneficiary, Recherche, subvention : 282693.6 €
- Marc becker (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Trajan scientific europe ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Toulouse (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Physikit ug (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Analysi (Grèce) — Partner, associated partner, Autres, subvention : 0.0 €
- Afekta technologies ltd (Finlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 286488.0 €
- Fasmatech epistimoniki kai technologiki anonymi etaireia (Grèce) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Violeitourgiki ike (imon international) (Grèce) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Friedrich-Schiller d'Iéna (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 260539.2 €
- Bruker (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université technique de Munich (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Thetabiomarkers ike (Grèce) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de l'est de la Finlande (Finlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Bright giant gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Eurac Research (Italie) — Partner, beneficiary, Recherche, subvention : 259437.6 €
- Helmholtz Zentrum München (Allemagne) — Partner, beneficiary, Recherche, subvention : 521078.4 €
- Université Aristote de Thessalonique (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 720295.2 €
- Capitainer ab (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €