Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ONGUARD (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : TERMINATED

Potato (Solanum tuberosum L.) is one of the world’s most important crops for human consumption, thus it is an integral part of the world's food supply. Poland is the world's 8th largest producer (2nd in the EU), with 9 million tons annually. Potato is susceptible to a wide range of pathogenic organisms, which can cause severe quality and yield losses worldwide. Given the absence of cultivars resistant to pathogens and the immunization of pathogen isolates to successive fungicides, any attempt to understand and strengthen the knowledge of factors related to natural potato immunity is extremely important. In light of this, it is well documented that nitric oxide (•NO) is a key element involved in pathogen recognition as well as activation of local and systemic plant defense signaling activities and pathways. Moreover, the interdisciplinary group proposing this plan recently reported endogenous production of HNO (nitroxyl) in plant tissues (Arabidopsis thaliana) for the first time, and points toward a novel regulatory role. Under physiological conditions, HNO concentration in plant cells is in the nanomolar range. The ubiquitous HNO bioavailability allows it to support or compete with •NO signaling, depending on the local redox environment (shifts with stress or senescence). Finally, we showed that HNO formation is an early reductive stress-related response. Taking all this into account, this proposal will focus on the real-time detection and visualization of simultaneously endogenous HNO and NO in leaves of the important crop plant challenge inoculated with vr/avr Phytophthora infestans, a cause of late blight disease. Moreover, it will be an important issue to answer the question of whether and to what degree the HNO presence in cells modifies the plant's defense responses. The hypothesis is that HNO is generated during potato - P. infestans interaction and can act as a functional signal molecule favoring redox changes towards effective defense responses in potato.

Mots clés : potato solanum tuberosum l , nitroxyl hno , nitric oxide no , endogenous gasotransmitter, pathogenic organisms, enhance effective defense responses, real time detection, bioinorganic sensors

Participants :
- École polytechnique de Poznań (Pologne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Adam-Mickiewicz de Poznań (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 155793.6 €
Projet MFCBioFactory (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The overarching objective of the MFCBioFactory project is to develop and evaluate a microbial technology for the treatment and generation of electrical energy using wastewater from the canned food industry and to characterize electroactive (EAMs) and non-electrochemically-active (non-EAMs) microorganisms involved in energy production and reduction using metagenomic sequencing and specific marker genes. A novel biofactory system that produces zero greenhouse gas (GHG) emissions, zero energy consumption, and allows the valorisation of the generated waste, known as a microbial fuel cell (MFC) together with a photobioreactor (Microbial Fuel Cell Biofactory, MFCB) will be developed. The metagenomic microorganism characterization will be used to optimize the performance of the electrochemical biofactory system. This project will allow the establishment for the first time of circular economy in the biological treatment of industrial wastewater that is difficult to treat and has a high salinity, thus contributing to the UN Sustainable Development goals, Green Deal (MSCA Green Charter), and UN’s Sustainable Development Goals. The MFCBioFactory involves a multidisciplinary research team including researchers and industry professionals dedicated to process engineering, bioelectrochemistry, applied microbiology, and chemistry.

Mots clés : biofactory, greenhouse emissions, electroactivity, microbial fuel cell, microbial metabolism, microbial diversity

Participants :
- Université de Grenade (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
- Helmholtz Centre for Environmental Research (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet GYROMAGS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Permanent magnets (PM) have a wide range of applications and play an important role in the realization of a sustainable future. With the increasing demand for green and renewable energy production and sustainability, comes a rise in popularity and demand for electric vehicles (EV) and hybrid electric vehicles (HEV) which use permanent magnet-driven electric motors. However; the development of technology and shrinking dimensions of parts used for such technologies has made post-processing and machining of the bulk PMs inevitable. This, in turn, leads to a 30% waste of the magnetic material as swarf/rejects. PMs are made of a combination of Rare Earth Elements (REE), transition metals (TM) and, some other elements. The scarcity of the REEs and volatile and unstable price of the TM market (especially Cobalt) has pushed the EU to encourage scientists to come up with feasible methods to revive the mentioned waste and thus achieve a circular economy and guarantee sustainable energy production and by doing that help the EU to achieve it's Green Deal Initiative goal set for 2050. The recycling of Samarium-Cobalt (Sm-Co) permanent magnets has been the target of a number of scientific studies, however; the proposed methods are all very energy-intensive and require a lot of mineral acids, and generate a huge amount of wastewater during the process. In this proposal, we suggest a green and facile method based on electro-deoxidation of the oxidized magnet swarf which will require much less energy consumption and will require a negligible amount of acids and chemicals compared to the conventional methods.

Mots clés : electro deoxidation, permanent magnet recycling, sustainability, rare earth recycling, magnetism, 

Participants :
- Institut Jožef Stefan (Slovénie) — Coordinator, beneficiary, Recherche, subvention : 171399.36 €
- Magneti ljubljana podjetje za proizvodnjo magnetnih materialov dd (Slovénie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet PerMSAA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Understanding spoken language requires listeners to map complex acoustic input onto linguistic representations in their mental lexicons. The difficulty of this process is increased by variation in the acoustics of spoken language. In particular, variation in how second-language (L2) speakers produce the sounds of a language (i.e., ‘foreign’ accents) can hinder the efficiency of speech perception. Prior work has indicated that listeners are highly adaptable, and can rapidly accommodate unfamiliar variation in accented speech, but what remains unclear is how listeners rapidly adapt to accented talkers. Many authors have proposed that listeners may “tune” to accented speakers by shifting their phonemic category boundaries (phonemic recalibration). However, attempts to directly link phonemic recalibration to accommodation of natural L2 accents have resulted in mixed outcomes. An alternative perceptual mechanism that has been proposed for accent accommodation is criteria relaxation. On this view, when encountering an unfamiliar accent, listeners relax their thresholds for accepting input as a particular phoneme, lexical item, and so on. Relatedly, listeners may rely less on categorical boundaries when processing L2 accent.  The primary aim of the proposed project is to improve our theoretical understanding of the perceptual mechanism(s) that support accent accommodation. In a series of three experiments, we will investigate the roles of phonemic recalibration and criteria relaxation using a combination of behavioral and psychophysiological measures. Specifically, our interdisciplinary approach will examine shifts in phonemic category boundaries and changes to within-category sensitivity, as well as the rate and cognitive demands of lexical activation for accented items. Ultimately, PerMSAA will increase our theoretical understanding of how listeners accommodate L2 accents, which is a skill that can be leveraged to improve overall communication between L1 and L2 speakers.

Mots clés : speech perception perceptual mechanisms accented speech accent accommodation pupillometry eye tracking

Participants :
- Basque Center on Cognition, Brain and Language (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet EPIC Read (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Dyslexia is often thought of as a deficit that causes someone to transpose letters within a word or to see letters backwards. However, decades of research have shown that people with dyslexia do not have issues with seeing letters, but rather with how they process the sounds associated with these letters. The purpose of the current project is to broaden our understanding of the underlying deficits in dyslexia and to identify clinical markers that can help with early identification. Most studies have focused on how individuals with dyslexia perceive speech sounds (using behavioral or neurophysiological paradigms). However, little is known about speech production ability in this population. Therefore, there is a critical need to examine production in this population which can later be used as an early diagnostic marker by speech language pathologists.  The current project combines both speech production and neurophysiological paradigms to better understand the underlying sources of dyslexia, and to identify new markers associated with reading disorders which we can be implement clinically. In the first experiment, I examine the relationship between phonological processing skills and speech production in typically developing children. This will inform how we can use speech production patterns to identify children at risk of developing dyslexia. In the second experiment, I examine whether neurophysiological brain data is associated with speech production markers in children with dyslexia. This project has important clinical implications on diagnosis and earlier identification of dyslexia.

Mots clés : reading, speech production, speech perception, auditory entrainment

Participants :
- Basque Center on Cognition, Brain and Language (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet POC-TDM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Cancer claims almost 10 million lives annually, making it one of the major causes of death around the world. Despite the development of novel drugs and treatment options, the 5-years survival of the most common cancers are still strikingly low. Chemotherapy (CT) is a widely used option to treat malignancies, however CT protocols are established on a “one size fits all” basis and ignore inter-patient differences in drug pharmacokinetics which influence the blood levels of anticancer drugs, therefore leading to improper dosing in 50% of patients. Missing target blood concentration will lead to drug resistance and/or unwanted side effects. Therapeutic Drug Monitoring (TDM) could be the key to improve and personalize CT, however the lack of an affordable point-of-care (POC) method is preventing its introduction to oncology. Mass spectrometry (MS) is the golden standard analytical approach to determine blood drug levels, but the instrument and specialized expertise to operate it are rarely available in the clinical environment. The high volume of blood required for MS analysis is also a challenge, because cancer patients are regularly weakened. Exploiting the strong and specific fluorescence of anthracyclines, the most used CT agents, we propose a radically new microfluidic chip-based approach to rapidly determine plasma concentrations of several widely applied anticancer drugs. Microvolume plasma separation and collection from a drop of blood (>50 ul) will be done with a specifically designed chip, then plasma anthracycline concentration will be measured using a compatible spectrophotometer. The approach will be validated using clinically relevant mouse tumour models and with samples from veterinary cancer patients. This interdisciplinary project, combining microfluidic engineering with cancer research, will introduce a novel POC-TDM system which could change CT treatments and improve survival through patient-tailored therapy.

Mots clés : cancer, chemotherapy, microfluidics, lab on a chip, personalized medicine, optical spectroscopy

Participants :
- Centre de recherche des sciences de l'Energie (Hongrie) — Coordinator, beneficiary, Recherche, subvention : 157622.4 €
Projet PLaSNAT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The trade-off between stacking fault energy and capability of twining has been a roadblock in aluminum (Al) composites, due to low dislocation storage and weak strain hardening ability. The recent extra strengthening and work hardening in gradient twinned architectures had provided an alternative approach to increase balance between nucleated twins, high density of dislocation and stacking faults. However, there is still a huge challenge to achieve large scale strengthening bulk Al which generally nucleate sporadically and under extreme conditions. We aim to develop a practical but innovative technique with combining stress concentration and high strain rate deformation at low temperature via powder metallurgy (PM) combined with cryogenic laser shock peening process (CLSP) to fabricate advanced, large scale, high strength twinned Al/graphene-CNT composites with uniform and controlled alignment including nucleated twins and stacking faults. The results are interpreted by both molecular dynamics simulation and experiments. During the cryogenic process, the pinning effect of CNTs hinders the escape of dislocations from pile-ups resulting in high stresses in front of graphene-CNT and controlling plasticity via both high strain rate and high pressure. As local stresses in front of both graphene and CNT exceed the critical stress for twin nucleation, high-density deformation twins can be formed. PM combined with CLSP enables us to tailor specific deformation nanotwins architecture in bulk Al composite otherwise cannot be achieved by present methods. Parameters of shock pressure, strain rate and loading temperature for optimal thermomechanical properties and even shock loading direction effect on alignment of graphene and CNTs for better strengthening effect and twinning nucleation in Al are discussed in details. We expect to demonstrate the feasibility of tailoring nanotwinned architecture in advanced Al composites via CLSP process, which could be put into mass production

Mots clés : aluminum graphene cnt composite, nanotwins, powder metallurgy, cryogenic laser shock peening, tailored architecture

Participants :
- Académie autrichienne des sciences (Autriche) — Coordinator, beneficiary, Recherche, subvention : 199440.96 €
Projet SRMS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Using additive manufacturing methods and the capability of introducing meta structures by four dimensional (4D) printing technology, the study of smart reinforced meta structures (SRMS) is one of the most attractive areas of research. Literature survey reveals that there is the lack of comprehensive research in this area. Therefore, there is a good potential to improve the design of meta structures using fiber-reinforced composite materials and to optimize and improve the quality of engineering structures. The proposed research program will deliver a novel, robust, efficient and accurate methodology for designing the 4D printed reinforced meta structures with nonlinear damaged structural segments. In addition, for identifying the existence of a certain damage type the ultrasonic wave actuation will be employed which has never been applied on composite meta structures before. To proceed the project, the 4D printer set up will be developed for fabricating the SRMS lattice structures for the first time. To examine the capacity of absorbed energy, the fabricated SMRS will be undergone the virtual and real experimental tests. Realization of the results of this research will make it possible to design structures with high energy absorption capacity that have suitable mechanical properties including higher special absorb energy to ideal weight. To characterize and monitor the potential damage mechanisms formed in the structures, ultrasound measurements will be employed for the first time in tessellated composite structures. For this aim, after calibrating ultrasound sensors, at different level of applied compressive load, the piezoelectric transducer excites propagating waves within the composite meta structures. The outgoing reflected and transmitted waves will be used for on quantifying and identifying damage.

Mots clés : smart meta structure, composite 4d printed structures, absorb energy, ultrasound measurement

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
- Université Nationale Technique d'Athènes (Grèce) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MyeMembrane (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Myelin plays a critical role in rapid action potential propagation and support of neuronal metabolism. Disruptions of its formation lead to severe neurodegenerative conditions, with multiple sclerosis (MS) ranking as the most prevalent demyelination disorder in the central nervous system (CNS). The Multiple Sclerosis International Federation estimates that around 2.9 million individuals worldwide are affected by MS in 2023, and its prevalence is increasing yearly. It is well established that myelin-specific membrane-embedded and membrane-associated proteins are essential for wrapping the oligodendrocyte membrane around the axons, forming the tightly packed membrane multilayers, constituting the myelin sheath. While the molecular identity of these proteins is known, there is no high-resolution structural information for any of the full-length CNS myelin proteins, and it is unknown how these proteins interact among themselves and with the surrounding membrane to form the myelin sheath. MyeMembrane seeks to throw structural insight on the myelin sheath assembly by visualizing principal CNS myelin membrane proteins in a lipid environment at high resolution, and to investigate the interplay between myelin proteins and the surrounding membrane using cutting-edge biophysical techniques. Unravelling the structural basis of myelin sheath formation is crucial for understanding myelin disorders, and for exploring new research avenues including the development of new treatments, endowing MyeMembrane with far-reaching scientific and societal impact.

Mots clés : myelin structure, cryo electron microscopy, membrane protein structure, neurobiology

Participants :
- Université de Bergen (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 210911.04 €
Projet PopLatin (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

PopLatin aims to write a new history of lay contemplative spirituality in the Middle Ages. Medieval people understood ‘contemplation’ as the highest religious experience: a revelation of divine love that could only occur, rarely, for those most committed to God. PopLatin offers a novel account of medieval contemplative spirituality by focusing on sources that scholars have largely overlooked: namely, the Latin textbooks that medieval priests used to teach their congregations. Latin priests’ books popularised famous medieval writers by transforming their teachings into more accessible forms, which priests then used to instruct their parishioners orally. The premise of PopLatin is that these neglected sources offer a new history of lay contemplative spirituality in the Middle Ages. By showing, counter-intuitively, that Latin was a language of popularisation through texts like these, PopLatin offers a radically revised view of what literature and beliefs ordinary laypeople could access during the centuries before the European Reformation. These objectives will be achieved through: literary analysis of four case studies, to establish how these Latin texts popularised the contemplative teachings of medieval authorities; analysis of material evidence, to show how priests communicated the teachings in their books to laypeople; survey of Latin priests’ literature, assisted by AI, to contextualise my research in wider trends; and literary analysis of the influence of Latin priests’ books on writers more famous today, to establish their importance for cultural history. This fellowship will enhance my career aim of securing a permanent academic position. It offers experience of a structured research project, which will ultimately form the basis of my next monograph, with one-to-one mentorship from a leading expert. It will develop my portfolio of teaching and public engagement, and enable me to contribute my knowledge of medieval Latin literature to research activities at UiB.

Mots clés : medieval studies, history of religion, history of the book, theology, history of christianity

Participants :
- Université de Poitiers (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Bergen (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 251578.56 €