Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ChromaFish (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

ADME (Absorption, Distribution, Metabolism and Excretion) studies focus on the examination and prediction of drug behavior in the human body. Zebrafish present a good in vivo model for this purpose since they comply with the 3R principle of humane animal research (Replacement, Reduction and Refinement). The research group of Prof. Deirdre Cabooter recently developed a novel sample preparation and analytical method to accurately measure the whole-body uptake of drugs in zebrafish. The next step is to further exploit the developed methodology to study other aspects of ADME, in particular uptake and metabolisation of new drug candidates in the brain. Since the blood-brain barrier is a major obstacle preventing many pharmaceuticals from achieving effective concentrations in the brain, infinite small concentrations are to be expected. The detection of low brain concentrations can be improved by using advanced analytical techniques with lower sample dilution and thus enhanced detection limits. An important part of this research project will therefore be devoted to the development and characterization of new capillary column formats based on core-shell particles offering unprecedented sensitivity and unique selectivities. A new brain dissection technique will moreover be developed to isolate the brain from the circulating blood and investigate the uptake and metabolisation of selected pharmaceuticals in the brain. Molecular transport routes will be unraveled and the uptake in specific parts of the brain will be investigated as well using laser microdissection microscopy. Finally, the potential of the developed methodology to provide a robust protocol for brain uptake measurements in industrial applications will be investigated by comparing the outcome obtained by zebrafish experiments with typical results obtained by more traditional models (murine, rat).

Mots clés : high performance liquid chromatography, capillary columns, core shell particles, mass spectrometry, adme studies, pharmaceutical uptake in zebrafish

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €
Projet AGENTSEGET (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

AGENTSEGET is an interdisciplinary project that will explore a neglected type of intellectual who grew to prominence in Europe at the end of the sixteenth century, a time of significant social and cultural upheaval. The religious conflicts, political tensions, and profound intellectual transformations of the decades around 1600 called for new styles of communication often involving subterfuge, middle-men, and disguise. A different type of intellectual was required to connect scholars in different and often troubled areas of Europe. Their task was to deliver scientific instruments, precious books and manuscripts crucial to the production of new knowledge and theories. To support themselves, they also traded information about princes, governments, religious factions and political machinations. The project will focus on the Scotsman Thomas Seget (1569/70-1627), one of the most interesting and less studied examples of this type of intellectual. By using Seget as a case study, AGENTSEGET aims to unlock the rich and vibrant personal and professional network of intellectual brokers and cultural middlemen in which prominent scientists such as Kepler and Galileo operated and thrived, exchanging ideas and receiving informal feedback on their work. The findings of AGENTSEGET are expected to demonstrate that cultural and scientific mobility has always been an essential component of the circulation and development of cutting-edge scientific research. The results will be disseminated through a monograph, Open Access publications, an interactive website, an edited volume, an exhibition, and a series of educational activities.

Mots clés : scientific revolution, cultural agents, intellectual networks, cultural mobility, thomas seget, galileo galilei, johannes kepler, justus lipsius

Participants :
- University of Edinburgh (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet ANIMATE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

ANIMATE investigates the spectacles staged at the Savoy court in Turin during the lifetime of the regent Christine of Bourbon-France (1606-1663). By examining objects and scenery, costumes and movements, this research explores how these virtual spaces performed new ways of thinking about the world, its natural resources and environments, at a time that saw a rapid increase in the circulation of bodies and things across borders. To pursue this aim, the study focuses on a large archive of extant – and understudied – visual and textual documentation: fourteen albums produced by court calligrapher, cartographer, and engineer Giovanni Tommaso Borgonio to document, over 1.117 manuscript pages, the performances in all their constituent elements. This investigation stems from my experience as a research associate with the project "Making Worlds: Art, Materiality, and Early Modern Globalization", based at McGill University, which examined issues raised by the global turn in art history and the humanities. By pursuing an art historical and cross-disciplinary approach, in the unfolding of this research I will i) further enhance my understanding of Italian visual culture in the context of global connectivity; ii) acquire new methodological tools for the critical evaluation of aesthetic practices from the point of view of ecology; iii) reinforce my mastery of an object of study – the courtly performance – that involved different types of media. The Art History Department at the University of California, Los Angeles, one of the first in the United States to embrace a mission of comprehensive global coverage, and the DAR at the University of Bologna, the largest multi-focused Department of the Arts in Italy, will constitute ideal settings in which pursue this investigation. The success of this project will strenghten my professional profile with the realization of my first monograph, thus boosting my chances of securing a tenure-track position within the DAR.


Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Bologna (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269002.56 €
Projet AQURI (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : TERMINATED

AQURI Poor air quality (AQ) is of major concern to policy makers and public alike, but is proving impervious to current mitigation efforts. In many areas, the dominant source of air pollution is the formation of secondary pollutants (ozone and aerosol) from the atmospheric reactions of volatile organic compounds, over 90% of which are biogenic in origin. Yet few atmospheric chemistry models currently used to simulate AQ include dynamic representations of interactions between the terrestrial biosphere and the atmosphere. Furthermore, elevated ozone concentrations damage vegetation, reducing productivity and altering emissions of biogenic ozone precursors. This project will address these critical omissions, developing a ground-breaking model of the exchange of trace gases and particles between forest canopies and the atmosphere that can be used to improve the performance of AQ models. The model will be applied to determine the effects of peri-urban forests on urban AQ and vice versa. Trans-disciplinary research in plant ecophysiology and atmospheric science at key experimental sites based in a peri-urban forest in central Italy and in a boreal forest in Finland will fulfill the specific scientific objectives: - Acquire and apply advanced micrometeorological techniques to improve understanding of forest-atmosphere exchange of trace gases and particles; - Develop a state-of-the-science model of the processes involved in these interactions, improving current parameterisations of deposition and uptake of air pollutants through plant stomata and introducing the effects of ozone damage to vegetation; - Quantify the effects of future change on urban and peri-urban AQ, and the resulting impact on the productivity of peri-urban forests; - Derive parameterisations of the key processes suitable for inclusion in regional AQ models. The resultant cutting-edge model will drive future research into the interactions of the land-atmosphere-AQ system and inform future policy.

Mots clés : air quality, forest ecosystems, atmospheric chemistry modelling, biogenic emissions, ozone, aerosols, biosphere atmosphere exchange, micrometeorological measurements, atmospheric measurements

Participants :
- Agricultural Research Council (Italie) — Coordinator, beneficiary, Recherche, subvention : 180277.2 €
Projet ARES (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

ARES (Attractive REsearchers in the Spotlight) is a project that unites six of the biggest Universities and Research Centres in Greece. ARES aims at organising six European Researchers’ Night events in 6 big cities (Athens, Thessaloniki, Patras, Heraklion, Larissa and Rethymnon) geographically covering Greece from north to south and demographically covering more than 60% of the Greek population. Thanks to a multi-channel marketing strategy comprised of a multitude of traditional and modern tools, a strong and extensive network of collaborators and the availability of hundreds of researchers, ARES’ ambition is to get into the households of two million citizens inviting them in the Nights while spreading the key messages of the ERN initiative such as the high-quality research that is conducted in Europe and its importance for our everyday life. Researchers of different career stages and profiles will present their work by visiting high-schools, through radio/TV interviews and will take part in intriguing pre-events that ARES will organise. This active involvement of researchers, selected also for their high communicative skills, will assist ARES in achieving one more goal; successfully fight the stereotype of the boring, male, researcher with the eccentric look that works in dark labs misusing technology for world domination. During the Nights, an array of activities, mostly led by researchers, is foreseen. Exhibitions with hundreds of technological products, hands-on experiments, scientific demonstrations, activities designed specifically for kids in the presence of distinguished researchers and with the engagement of university students, combined with various entertaining activities will give visitors the opportunity to delve into the amazing world of research. Thanks to the size of the cities, the carefully selected venues, the thorough awareness campaign and the appealing programme of the Nights, ARES expects to receive more than 25.000 visitors at its events.

Mots clés : research, science, education, entertainment, edutainment, events, public, students, greece, athens, thessaloniki, larissa, patras, heraklion, rethymnon

Participants :
- University of Patras (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20875.0 €
- Centre for Research and Technology Hellas (Grèce) — Coordinator, beneficiary, Recherche, subvention : 55625.0 €
- National Technical University of Athens (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 24437.5 €
- Foundation for Research and Technology Hellas (Grèce) — Partner, beneficiary, Recherche, subvention : 19875.0 €
- Hellenic Mediterranean University (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 12412.5 €
- University of Thessaly (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 19500.0 €
Projet ARPOEXMUS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

ARPOEXMUS explores what role musicology can play in ensuring the storage, preservation, management and curation of post-1960s experimental music. For the first time, this project addresses the theoretical, ontological, methodological and ethical issues that arise from archiving the heterogenous instruments, objects, electronic devices, software, and custom-built materials that have been at the heart of sonic arts for the past 60 years. Drawing on a set of comparative case studies, ARPOEXMUS engages with three different paradigms: 1) objects as scores, instruments and sculptures and their preservation in musical archives; 2) custom-made electronic instruments and collaborations with science and technology museums; 3) obsolescence and digital heritage. These will be tackled using insights from contemporary musicology and archival studies that challenge the assumptions of permanence and stability upon which the ‘work concept’ is based. ARPOEXMUS uses qualitative data analysis, comparative analysis, media theory, and action-based research to explore in detail: 1) the ontologies set forth by each case study; 2) current conservation practices to archive and conserve these ontologies; 3) innovative conservation practices designed specifically for these new ontologies. Bringing together an ER whose expertise covers 1960s and ’70s experimental music and archiving, a Supervisor who is a leading voice in the process of decolonisation and diversity in music studies and a Co-Supervisor who is a leading scholar in contemporary digital musics and sound art, ARPOEXMUS will contribute new insights and initiatives for scholars, archivists, and practitioners.

Mots clés : experimental music, electronic music, music archive, music ontology

Participants :
- Carleton University (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276498.24 €
Projet MIRAGE (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

ARVC is a hereditary disease mainly characterised by the progressive substitution of the myocardium with fatty or fibro-fatty tissue involving predominantly the right ventricle. Clinically, ARVC shows wide variation between individuals. Together with modifier genes, common sequence variants, and environmental as well as endogenous factors, epigenetic modifiers such as miRNAs are hypothesized to be potential targets for disadvantageous environmental stimuli and may lead to the onset of complex and heterogeneous diseases such as ARVC. The main research objective of this EF is to assess and validate the relevance of disease mechanisms underlying the development of ARVC and to identify novel RNA-based targets in mouse models and ARVC patients. The EF programme comprises two tightly linked components – research and complementary training - that will be complemented with secondments in two (non-) academic organisations active in the field of molecular cardiology. The host organisations are strongly committed to enhancing the creative and innovative potential of the ER who wishes to diversify her individual competence in terms of skill acquisition to become a successful European scientist.

Mots clés : arvc, mirna, therapeutics, cardiac tissue

Participants :
- Maastricht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet KinGrad-OCM (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Abundant availability of methane makes this compound being a potential substitute to crude oil for ethylene production if such chemical conversion is feasible. The direct transformation of methane into olefins via Oxidative Coupling of Methane (OCM) is nowadays still considered as a “dream” reaction for the direct production of ethylene from methane. This process remains a huge challenge in chemical engineering research. A better understanding on how the reaction proceeds in space and time in the reactor (mechanism and kinetics of the process) and the development of advanced efficient catalysts are crucial steps to achieve the industrial implementation of the process. The traditional methodology to evaluate catalytic performance and addressing kinetic analyses, which consists on the assumption of a constant temperature for the catalytic bed and the evaluation of the gas composition at the reactor outlet, seems not to be a suitable strategy for chemical processes such as OCM. KinGrad-OCM aims to set up a new methodological approach based on the application of operando spatial reactor analysis techniques for the study of the OCM reaction both in conventional furnace heated and microwave-assisted reactors. A particular focus is given to the assessment of reaction kinetic by the operando spatial reactor analysis through the physicochemical gradients present in the reactors. The successful application of the gradient approach, proposed in KinGrad-OCM, for assessing kinetic studies will yield a new perspective to both catalyst and reactor design not only for the OCM process but also for other complex chemical reactions.

Mots clés : oxidative coupling of methane, reaction kinetics, operando spatiotemporal reactor analyses, operando spectroscopy, microwave assisted reactor, structured catalysts

Participants :
- Delft University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187572.48 €
Projet ProRegScaffold (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

According to Allied Market Research, the market for nerve repair and regeneration is expected to reach €11 billion by 2023, with an annual increase of 13%. Autograft, the gold standard, only achieves a success rate of about 45%, despite intrinsic drawbacks including availability and comorbidities. Neural scaffolds offer the bright prospect of nerve injury treatment by guiding axon sprouting and creating a permissive microenvironment. However, current products including NeuraGen® and Neuromaix® failed to find their way towards widespread clinical practice due to their dimensional instability and the mismatch of regenerated axons, as well as showing no effect on the intrinsic regenerative capability of neurons. To address the current technological gap, this project aims to develop a proregenerative scaffold (ProRegScaffold) that completely mimic the microenvironment of host tissues to guide axonal growth, promote regeneration and stimulate integration into the existing healthy tissue. The ProRegScaffold comprises of chitosan/collagen microchannels resembling the geometries of native nervous network, which will be tailored by precisely controlling the growth of ice crystals within digitally predefined moulds. This is an automated method amenable to low-cost and large-scale production. Near infrared light responsive lipid nanoparticles will be introduced and filled with growth factors to activate the intrinsic regenerative capability of neurons. Moreover, I will complement the finite-element method (FEM) with machine learning algorithms to accelerate the design phase, analyze structural mechanics and provide proper parameters of scaffolds allowing faster axon regrowth. This project represents cutting-edge research to screen structure-activity relationships for effective nerve repair, allowing the establishment of a practical personalized neural scaffold.

Mots clés : biomimicry, scaffold, ice templating, 3d printing, personalized clinical therapy, stimuli responsive, nerve injury repair, tissue engineering, machine learning

Participants :
- Karolinska Institutet (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191852.16 €
Projet PVCI (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

According to the "Europe 202 strategy", Europe should increase the use of photovoltaics (PV) and other renewable energy sources (RES) for a sustainable future. However, to this day, PV plants are not-controllable power sources, thus imposing limits on PV penetration due to technical restrictions. The PVCI project will investigate these limitations and will provide solutions through a coordinated PV control strategy for combined frequency and voltage regulation. The two main objectives are: (a) development of a smart inverter control scheme to provide ancillary services to the grid, and (b) derivation of an enhanced network management strategy to coordinate PV plants and other network equipment for smooth and optimal grid operation. This is a holistic approach to the problem, simultaneously addressing frequency and voltage regulation, as opposed to the research made so far which treats these issues separately. The research is very timely, as the leading PV deployment faces stagnation and several European countries have already reached their upper limits in PV penetration. This project is aligned with the European strategy to be more resource efficient and less energy-dependent on other countries. The Researcher obtained very recently his PhD degree on PV modeling and control, and wishes to enhance his portfolio on the fields of distributed generation and power systems. He has derived PV models that will be useful for this research and has already started investigating these topics, while the Supervisor has international research reputation in renewable energy integration and so is the best option for this cooperation. The fellowship will significantly contribute to the Researcher's professional development, through outstanding training, public engagement, dissemination of results and 2-way transfer of knowledge with the Host’s research group.

Mots clés : photovoltaics  pv, power converter and control, power distribution networks, frequency regulation, voltage regulation, reserve and ancillary services, optimization

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €