Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MNEMONIC (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The aim of this interdisciplinary project is to develop composites consisting of metal-organic frameworks (MOFs), magnetic nanoparticles (MNPs), and enzymes. The MOF coating protects the biomacromolecule from inhospitable conditions, and provides a permeable and selective molecular gate for the diffusion of substrates and products, thanks to its intrinsic and tunable porosity. External magnetic forces acts on the MNPs to allow for precise positioning of this ternary system. These highly efficient, long-lasting, robust, and dynamically positionable crystalline biocatalysts will be synthesized using the recently discovered biomimetic mineralization process, in which MOF precursors, metal ions, and organic ligands nucleates on the biomacromolecule without the need of stabilizing polymers or organic solvents, in aqueous solution at room temperature. This innovative technique has been proven successful for a wide range of protein and enzymes, and is currently the best performing procedure available for this class of porous material in terms of efficiency of enzyme encapsulation, absence of leaching, and reactions conditions and time. Key aspects of the project will be: the production of enzymes suitable for a multistep process; the synthesis and characterization of the composites; finally their integration into fluidic devices. The effects of process variables on particle size and morphology, enzyme loading and activity, MOF robustness, magnetic properties, and recyclability of the composite will be investigated with a multifaceted analytic approach. The long-term impact of this project includes technological benefits for industrial biotechnology, owing to the superior resistance of MOF-coated enzymes towards organic solvents, heat, and inhibitors, along with the presence of MNPs that permits the easy recovery of the MagEnzMOFs and their integration into fluidic reactors, to provide continuous production with high automation.

Mots clés : metal organic framework, magnetic framework composite, magnetic nanoparticle, enzyme, encapsulation, biomimetic mineralization, fluidic device, industrial biotechnology

Participants :
- Graz University of Technology (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166156.8 €
Projet MetaPlat (Horizon 2020, appel à projets 2015)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : CLOSED

The aim of this project is to bring together experts from the academic and non-academic sectors and to create an easy-to-use integrated hardware and software platform. This will enable the rapid analysis of large metagenomic datasets. It will provide actionable insights into probiotic supplement usage, methane production and feed conversion efficiency in cattle. In the recent years, the number of projects or studies producing very large quantities of sequencing data – analysing microbial communities make-up and their interactions with the environment – has increased. Yet, the depth of analysis done is very superficial and represents an inefficient use of available information and financial resources. This project aims to address these deficiencies and will study the change within microbial communities, under various conditions in cattle guts and impacting probiotic supplement usage, methane production and feed conversion efficiency in cattle. To succeed, we propose to develop faster and more accurate analytic platforms in order to fully utilise the datasets generated. By focusing on better hardware and software platforms, better expertise and training, this project will pave the way for a more optimal usage of metagenomic datasets, thus reducing the number of animals necessary. This will ensure better and more economic animal welfare. The Meta-Plat project objective is a mixture of innovative research, focused application and commercial awareness. The core objectives being pursued are: • Sample gut collection, from cattle, for sequencing; • Collection of publically available databases – to create a new classification of previously unclassified sequences, using machine learning algorithms; • Development of accurate classification algorithms; • Real-time or time-efficient comparison analyses; • Production of statistical and visual representations, conveying more useful information; • Platform integration; • Provide insights into probiotic supplement usage, methan

Mots clés : bioinformatics, metagenomics, microbiome

Participants :
- Research Institute for Telecommunication Cooperation (Allemagne) — Partner, beneficiary, Recherche, subvention : 135000.0 €
- University of Ulster (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 90000.0 €
- Scotland's Rural College (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 54000.0 €
- University of Naples Federico II (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 54000.0 €
- Nsilico life science limited (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 315000.0 €
Projet SAGE-CARE (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : CLOSED

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to create a holistic informatics platform for rapidly integrating genomic sequences, electronic health records (EHRs) and research repositories to enable personalised medicine strategies for malignant melanoma treatment. The consortium has engaged in a pre-proposal process with active clinical end users who have highlighted the need for more innovative approaches for the treatment of cancer - in particular the treatment of malignant melanoma, including inter alia the ability to rapidly query of geno-phenotype associations in melanoma such as the recently discovered rs2301641 SNP variability with ABCB5 function and CDK4 gene indicators . Hence we aim to develop a scalable HPC framework that allows the semantic interlinking between spatially distributed electronic patients’ health records, associated genomic sequences and published research, thereby allowing clinicians to make reasoned queries over vast knowledge bases for the diagnosis, treatment and management of malignant melanoma.

Mots clés : gene ontologies, semantic integration, scalable bioinformatics

Participants :
- Darmstadt University of Applied Sciences (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162000.0 €
- Ubitech (Greece) (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 40500.0 €
- University of Naples Federico II (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 27000.0 €
- Nsilico life science limited (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 220500.0 €
- University of Edinburgh (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ChemoEnz (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : CLOSED

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to develop a platform of “green” chemoenzymatic methods for the production of high value active pharmaceutical ingredients – both those currently on the market, and those in development pipelines of the Pharma industry. The partners will exemplify the use of the platform through its application in the production of 4 drugs currently on the market – namely Duloxetine, Atomexetine, Ramosetron and Paricalcitol. In order to achieve this objective the proposal brings together 3 partners with complementary skills: Kelada Pharmachem: Phase transfer catalysis/organo catalysis/scale-up of chemical processes Cerbios Pharma: Biocatalysis and fermentation methodologies for drug production IC-CNR: Protein crystallography and enzymatic engineering

Mots clés : organocatalysis, green chemistry, process development

Participants :
- Cerbios (Switzerland) (Suisse) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- National Research Council (Italie) — Coordinator, beneficiary, Recherche, subvention : 162000.0 €
- Kelada Pharmachem (Ireland) (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 72000.0 €
Projet Tick ThaNK (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The aim of this project is to determine the role of natural killer (NK) cells, effector players of the innate immune system that target virally infected cells and tumor cells, in the infectious disease Tick-borne encephalitis (TBE). By elucidating their function either in enhancing or suppressing the disease in two different compartments, central nervous system (CNS) and peripheral blood, we seek to generate knowledge that will provide new insights into innate immunity that could lead to novel strategies to improve treatments for infectious diseases. This project is intended to take place mainly in the Center of Infectious Medicine from the Department of Medicine at Karolinska Institutet (KI) in Stockholm. To complement the scientific training proposed, a secondment of two months will be carried out at the VU University Medical Center in Amsterdam, Netherlands. Overall, the goal of the present application is to support the restart of the scientific formation of the applicant, who has made a 2-year career break due to maternity leave. The short-term objective of the current study is to provide training of the researcher in advanced cellular characterization, labeling, and bio-imaging techniques, synergistically with trans-European mobility, reinforcing her scientific, managerial and leadership qualities. A mid-term objective is the progress of the researcher’s career in science and the broadening of her scientific horizons, and a long-term aim is the Fellow’s setting as an independent investigator.

Mots clés : natural killer cells, flavivirus, blood brain barrier, cerebrospinal fluid

Participants :
- Karolinska Institutet (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185857.2 €
Projet ROCOCO2HP (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The aim of this project is to develop efficient real-time optimal control (RTOC) for the carbon dioxide (CO2) heat pump as a part of a building energy supply system and validate its reliability experimentally. This is necessary to increase the system efficiency. For a high system efficiency with CO2 heat pumps for heating purpose, a low water return temperature from building heating systems is crucially important. However, this is still difficult to achieve due to well-established heating solutions and control strategies that are not suitable for CO2 heat pumps. CO2 is considered as one natural refrigerant, which has the merit of nonflammability, non-toxicity, and low price when compared with traditional refrigerants. Current well-functioning control methods are developed for heat pumps based on HFCs. Current RTOCs have the disadvantage of large computational load, which makes them difficult to operate with real building energy systems. Furthermore, experimental validations for the developed RTOC cannot be conducted due to lack of advanced experimental conditions. A reliable and experimental-validated RTOC for CO2 heat pump systems is urgently needed. This project will be developed by combining my scientific expertise on RTOCs with advanced experimental conditions with the CO2 heat pump for residential heating use at the host laboratory. Model-based predictive control (MPC) will be used to develop the RTOC. Machine learning methods will be used to develop the non-linear system model. Further, the RTOC with multiplexed optimization strategy (MOS) will be implemented in simulation environment. After the reliability of the developed RTOC in simulation environment is validated, the RTOC will be tested in experimental conditions. Finally, the reliability of the developed RTOC will be validated in experimental conditions. This project will bring new knowledge and theories to develop the RTOC for CO2 heat pump systems and will help me become an independent researcher.

Mots clés : co2 heat pump, real time optimal control, residential use, energy efficiency, thermodynamics, simulation, experimental study

Participants :
- Norwegian University of Science and Technology (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202158.72 €
Projet DAFNEOX (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Physics
Statut du projet : CLOSED

The aim of this project is to develop new inexpensive, scalable and efficient bottom –up approach for positioning nanoobjects in regular patterns and to implement them in optoelectronic technology, which is the major challenge in nanotechnology today. The synergy between the quasi zero-dimensional elements and functional oxides with an exceptional range of properties (ferromagnetism, ferroelectricity, …) opens a completely new concept to nanoelectronics. Devices based on these materials would offer functionality beyond the achievable limits, with wide range of applications from spintronics and catalytics to optoelectronics. To achieve this objective, controlled integration of nanoelements on top of self-organized functional oxide nanotemplates will be explored. Optimum conditions will be achieved by a synergetic approach: growth processes will be guided by theoretical studies followed by an exhaustive charge transport, optical and magnetic characterization. In addition, transport and optoelectronic properties of the individual nanoelements will be studied separately to gain insides about their fundamental characteristics and serve as a model system in the interpretation of complex nanoparticle/oxide behaviour. The specific applications targeted in this proposal are based on novel photonic and spintronic materials. We will focus on obtaining devices with the highest photonic response and spin control. Our project brings together experts in experimental and theoretical physics including materials science and advanced magnetoelectronic/spectroscopic expertise and one spin-off which will ensure proof of concept of a new generation of optoelectronic devices. The complementary background of different groups and the foreseen mobility will assure the good development of this proposal. The proposal will be realised in iterative steps between preparation, advanced characterization and theoretical prediction up to implementation process through Spin-off Company.

Mots clés : thin film oxides and nanoparticles, advanced functional materials, nanostructured materials

Participants :
- Senzor infiz doo (Serbie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 45000.0 €
- Federico Santa María Technical University (Chili) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 243000.0 €
- Delft University of Technology (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 229500.0 €
- University of Chile (Chili) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut Català de Nanociència i Nanotecnologia (Espagne) — Partner, beneficiary, Recherche, subvention : 40500.0 €
- KU Leuven (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 27000.0 €
- University of Belgrade (Serbie) — Partner, beneficiary, Recherche, subvention : 184500.0 €
Projet MICEXPRESS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The aim of this project is to enhance our understanding of how genetic selection for body weight in mouse drives changes at the RNA level. This is a key point for quantitative genetics because a better knowledge of the genetic control of gene expression would imply a better prediction of changes in the regulatory networks and subsequently in the phenotype. Moreover, the biological insight gained by this understanding could, in turn, be used by the animal breeding industry to design more efficient breeding strategies. However, generally, genetic studies focus on understanding mean phenotypic differences among genotypes, although genes can also lead differences in the phenotypic variance between genotypes. Thus, this research will use a systems approach to model the genetic control of both, the mean and the variance of gene expression, and to identify regulatory networks than can be modified by selection. In addition, important environmental effects, such as maternal effects (e.g. uterine capacity), play an important role on the response to selection for growth in mammals. The second project aim is to elucidate how maternal effects shape the expression of genes and gain insight into the mechanisms underpinning gene by environment interactions. The recent emergence of high throughput technologies such as mRNA sequencing allows the study of the genetic and environmental makeup of cellular phenotypes. Furthermore, answering these questions require experimental designs and biological resources that are not usually available. The Roslin Institute has an extraordinary resource to carry out this research. After many generations of divergent selection for body weight multiple mouse lines were inbred, and kept inbred through brother-sister mating for over fifty generations. Four of these lines will be used in the current project. Hence, this project will capitalize on this extraordinary resource jointly with the emerging genomic tools for addressing these important questions.

Mots clés : quantitative genetics, animal breeding, divergent selection experiments, gene expression, maternal effects, environmental variation, robustness, phenotypic variability, mice

Participants :
- University of Edinburgh (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet METODA (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of this project is to explore how the repertoire of qualitative methods in the social sciences can be enriched by integrating methods and techniques from the fields of design and art to develop creative and novel modes of doing imaginative and critical research. This project attempts addresses recent calls within some social science disciplines such as sociology, human geography, media studies, anthropology, and Science and Technology Studies, for renewed approaches to methods. Recent works within different social science disciplines have stressed the need for methodologies capable of attending to the social and cultural world as mobile, digital, messy, interconnected, creative and sensory. There have been calls for social science methodologies that not only describe the worlds they observe but also are capable of intervening in and transforming them. This project begins from the premise that the creative, expressive, and participatory methods, techniques and practices within the fields of design and art constitute fertile ground for developing methodological innovation within the social sciences. The project will develop a database of examples of projects that have developed interdisciplinary methods between social science and design, conduct interviews with academic researchers and industry practitioners using innovative methods conduct workshops to explore how new methodological tools for collecting analyzing and communicating research data can be developed and applied. Ultimately, the project will develop new knowledge and innovation on interdisciplinary methods between design and the social sciences and develop new methodological tools and devices for collecting, analyzing, and communicating research data.

Mots clés : interdisciplinary methods, design, social sciences, devices, practices

Participants :
- University of Warwick (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 137591.1 €
Projet MeTABLE (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : CLOSED

The aim of this proposal is to acquire new insights about the mechanisms of environmental adaptation, particularly for cold-adapted organisms, and to discover novel metabolic pathways and enzymes with potential industrial value. We intend to accomplish this goal by establishing a collaboration and a knowledge-exchange network between industrial and academic partners aiming at developing bioinformatic tools for genomic analysis and biotechnology tools for directed evolution. The partners present high complementarity: UNICAM holds genomic sequences from psychrophilic and mesophilic ciliates that need to be annotated and analysed. Sabanci provides environmental samples for the isolation and characterization of new extremophiles. CAMBRIDGE provides the know-how for the discovery of new metabolic pathways valuable for understanding environmental adaptation. BMR Genomics and COMSATS possess all the facilities for genome sequencing and annotation and bioinformatic expertise with the purpose of developing new tools to analyse genomes of microorganisms from extreme environment. UNIMIB owns the facilities for the heterologous expression of gene sequences in bacteria and yeasts and technologies to assess and implement the properties of novel enzymes towards industrial application. We are confident that the establishment of the international research network proposed, with its synergistic effects, will significantly contribute to push all the involved laboratories to the top level in the field of production of active biomolecules and in the discovery of mechanisms of molecular adaptation under extreme environmental conditions. These discoveries may help the manufacturing of a new generation of ordinary facilities, as cleaning agents, biofuels, with a significant impact on the everyday life of European citizens.

Mots clés : sequence annotation, environmental adaptation, molecular evolution, microorganisms, ciliates, psychrophiles

Participants :
- Università di Camerino (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 81000.0 €
- Biomolecular Research Genomics (Italy) (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 45000.0 €
- Epigenetiks genetik biyoinformatik yazilim as (Turquie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 130500.0 €
- Sabancı University (Turquie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- COMSATS University Islamabad (Pakistan) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 22500.0 €
- Elvesys (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Milano-Bicocca (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 58500.0 €