Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet RATIO (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This project aims to study the structure, dynamics, and reactivity of prominent alkali and alkaline-earth organometallics species by ab initio and multi-scale computational approaches. Main group organometallic compounds are cheap and mostly non-toxic; therefore, they are appealing to industrial processes and are employed today in an ever-growing list of reactions, including drug synthesis or fertilizer manufacturing. In fact, little is known about their molecular structures in solution and the mechanisms by which they react, hampering the development of more efficient reagents or experimental conditions. This is due to their highly fluxional nature, yielding a diversity of structures in fast equilibria controlled by the solvent. Ab initio molecular dynamics offers the best way to investigate these systems, as demonstrated by recent studies unveiling the structure of a pure Grignard reagent and its reaction with carbonyl substrates in a THF solution (Peltzer et al, JACS 2020). This project expands the horizon over considerably more challenging and intriguing members of the Grignard family, formed by mixing metals species or solvents, which show unexplained synergistic effects on reactivity and selectivity. First, the project will characterize the structures and reactivity (Mg-C bond formation) of mixed Mg/Li turbo-Grignard and turbo-Hauser reagents in solvent. Then, attention will be drawn on the recently discovered remarkable synergy produced by running the Grignard reaction in non-miscible mixture of organic and green deep eutectic solvents. By understanding the role of the mixed solvents for these reactions, the project aims to open the route for the design of cheaper and environmentally friendly experimental conditions. The project, carried out in collaboration with an international experimental leader will have a great positive impact on the applicant's career identifying him as one of the key players in the development of green efficient main group chemistry.

Mots clés : main group metals, grignard reagents, ab initio molecular dynamics, density functional theory

Participants :
- Université d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 210911.04 €
- Université de Berne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet WaterDecor (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Hydraulic installations play a fundamental role in human survival, development, and the prosperity of urban settlements, mostly in semi-arid regions. In this regard, WaterDecor plans to investigate nymphaea and public fountains in Iudaea/Syria-Palaestina and Provincia Arabia from the establishment of the Roman province until the Byzantine Period (ca. 1st BCE-7th century CE). It analyses the ways in which these water management installations were built across this vast semi-arid geographical area and evaluates cultural, social, and economic implications. Through a historical perspective and the record of past societies, this project embraces the EU’s challenges in the field of climate action and resource efficiency, bringing awareness to the importance of conscious water use. Furthermore, in line with the strategic framework for the EU’s cultural policy and the European Neighbourhood Policy (ENP), this research promotes international cultural relations with southern neighbours (Israel, Syria, Jordan, Palestine, Lebanon). The project’s novelty consists in considering a group of infrastructures from a vast geographic area over time and, most importantly, it undertakes an overall examination that moves away from traditional studies based on individual monuments or typology stricto sensu. It delves into a multitude of aspects that makes it possible to enhance several issues spanning from ancient technologies to climate change issues. The specific objective focuses on nymphaea and public fountains in a context of semi-arid o arid climatic conditions, which makes the construction of large water-consuming structures challenging. The second objective investigates urban and socio-cultural contexts and how these constructions were perceived by the local population. The third objective examines climate change effects on these structures and, in general, on the urban water distribution system.

Mots clés : jewish studies

Participants :
- Université d'Udine (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 320924.16 €
- Université hébraïque de Jérusalem (Israël) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université de Berne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet T1SIA (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

People with type 1 diabetes (T1D) live with the burden of self-managing their glucose levels. Although automatic insulin delivery (AID) systems have alleviated this load, patients still need to count carbohydrates and administer insulin boluses at mealtimes, making the systems prone to human errors, which could have severe health consequences. Adjunctive therapies such as GLP-1 receptor agonists aim to mitigate these risks by reducing the impact of meals on the glucose rate of appearance in blood. These drugs are prescribed for type 2 diabetes, but they are currently being considered for their use in T1D. Simulators are one of the essential tools for developing AID systems and the foundation for digital twins, allowing testing and validating control algorithms while avoiding any risks for the patients. However, no T1D simulator includes descriptions of GLP-1 effects. The T1SIA project will develop a T1D simulator that includes a mathematical model of GLP-1 receptor agonists’ dynamics. This 2-year project will rely on the experience of the University of Bern and the Polytechnic University of Valencia. The first year at Bern will focus on developing a GLP-1 mathematical model, supervised by an expert in AID systems and a clinician expert in adjunctive therapies. In the second year at Valencia, the model will be integrated into a T1D simulator alongside a cohort of virtual patients under the supervision of an expert in diabetes technology. T1SIA will allow exploring the contributions of these novel therapy drugs for research and product-development purposes in the AID and pharmaceutical industry. This project will push the candidate’s professional development, both for academic and industry positions, improving her knowledge of mathematical modeling, human physiology, and identifiability processes while also providing the candidate with skills in project management, networking, teaching and supervision, and communication.

Mots clés : type 1 diabetes adjunctive therapies glp 1 automatic insulin delivery

Participants :
- Université polytechnique de Valence (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 243096.72 €
- Université de Berne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet GRADMAP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Here I propose an ambitious project designed to explore an exciting new hypothesis: TFs are non-randomly spatially organised within the cell nucleus, forming radial gradients that likely play an important role in regulating gene expression. This idea was born from one of the intriguing discoveries revealed by Genomic loci Positioning by Sequencing (GPSeq), a technique developed in the host lab, that the binding motifs of the majority of human transcription factors (TFs) seem to form radial density gradients, with some TF binding motifs being more abundant towards the nuclear periphery, whilst others more abundant in the centre. Furthermore, preliminary analysis showed that the predicted binding motifs of master regulator TFs specifying lymphoid vs myeloid lineages form opposing radial gradients, suggesting that this mode of transcriptional regulation is critical for cell fate specification. In this project, I will differentiate hematopoietic stem cell (HSC) into opposing lineages (lymphoid/myeloid) and perform TF CUT&RUN to assay TF occupancy and chromatin landscape, coupled with GPSeq to assay the radial arrangement of chromatin in these lineages. The intersection of these two genome-wide datasets will provide the first ever map of the occupancy of lineage specific transcription factors through differentiation time and nuclear space with respect to radiality. In parallel I will generate additional omics datasets in these cell populations to assay chromatin accessibility, transcription and chromatin interactions to build a comprehensive, multi-dimensional genomic atlas in which the spatial arrangement of TFs can be linked with gene expression dynamics. Crucially, no other study has thus far addressed this novel hypothesis; my work will provide significant advancements in understanding the interplay of genome architecture with transcriptional regulation and cell-fate specification.

Mots clés : genome architecture 3d genome chromatin transcription factors gene expression radial nuclear organization lineage specification differentiation genome wide analysis

Participants :
- Human Technopole (Italie) — Coordinator, beneficiary, Recherche, subvention : 193643.28 €
Projet SCENIC (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

New investigations of the inscriptions from Crete are highly desirable and expected by historians and epigraphists of ancient Greece. The Inscriptiones Creticae (I.Cret.), vol. I-IV, published by M. Guarducci between 1935 and 1950, lacks both of the fifth volume, which should have been devoted to the inscriptions of Cretan localities that are no longer identifiable, and of a supplement on inscriptions discovered in the last 90 years. Many of the 15 geographical corpora included in the Inscriptiones Graecae (IG: the most important project on Greek epigraphy), such as those from Attica or Boeotia, received an update after many decades. Because I.Cret. was independently published, Crete was not a priority for IG, and an update dedicated to the Cretan inscriptions never appeared. Therefore, a new edition of all inscriptions from Crete is strongly needed, but it is beyond the possibilities of a single scholar, requiring a very long time. Excluding the re-edition of those inscriptions already collected in I.Cret., the proposed project is consistent with the time scale of a MSCA and would be beneficial to several disciplines. Specifically, it aims at providing: i) a corpus of the Cretan inscriptions not included in I.Cret. A broad scientific impact can be expected, as this corpus will be in synergy with I.Cret. and with findings from other fields (e.g. prosopography). ii) an open access digital database to make the result easily accessible. This digital database will help in improving the most popular open access epigraphic publishing projects for Greek inscriptions. The open-access database of epigraphic material will also be made palatable to a broader public, accompanying the collected inscriptions with photos, English translations, commentary, etc. Following the epigraphic tradition, a book edition in Latin will be printed, addressed to a specialised audience. Gender, social and environmental aspects, although not central to the project, are taken into account.

Mots clés : greek epigraphy, greek history, crete, archaeology, classical reception

Participants :
- Université de Foggia (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 297164.16 €
- Foundation for Research and Technology Hellas (Grèce) — Partner, associated partner, Recherche, subvention : 0.0 €
- Scuola archeologica italiana di atene (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Berne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet NIPMAP (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The current global biodiversity crisis requires rapid, inexpensive and reliable methods of detecting the main threats to species’ survival: pathogens, habitat change, and loss of genetic diversity1. Equally crucial are solutions for stemming biodiversity loss: we lack vital models that determine how these threats interact, which would help prioritise conservation efforts. Recently, CRI-CG has discovered for one species of frog over a relatively small geographic area that eDNA extracted from water samples captures more genetic diversity than analyses using tissue samples (UNESCO-funded project ACQUAVIVA). The same eDNA can be used to detect amphibian pathogens. NIPMAP will apply this knowledge in an innovative way by: i) optimizing this eDNA approach to estimate mtDNA diversity in four amphibian taxa (two caudates, two anurans) and pathogen diversity (principal pathogens: Bd, Bsal, Rv) across the eastern Italian Alps; ii) using these data to inform individual-based and spatially explicit simulations of host movements and pathogen transmission37; iii) integrating parameters from i-ii with skin microbiota and other health indices, as well as iv) environmental variables at each sample site, to generate correlative models (e.g. GLMMs and SDMs) and potential distribution maps to direct conservation management decisions. We will also pilot two innovative eDNA protocols: one to measure nuclear DNA diversity (to measure current gene flow and dispersal rates) and one to understand microbiota function using metatranscriptomics. These interdisciplinary tools will be integrated into a workflow that will be applicable to animal taxa anywhere on the planet.

Mots clés : non invasive sampling, microbiota, pathogen ecology, 

Participants :
- Edmund Mach Foundation (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
- Université de Ferrare (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Museo delle Scienze (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet ECHOINGWARS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

ECHOINGWARS will study how variations in war narratives develop within a globally dispersed community and impact the conflict through feedback mechanisms. While communities directly experiencing war and those in exile are usually studied separately (conflict studies and refugee studies), it is crucial to consider these globally dispersed communities as interconnected and key actors in the construction of war narratives. However, these communities experience narrative variations based on their location, encompassing both similarities and differences. The project's originality lies in viewing these narrative variations as essential to understanding their potential impact on the conflicts themselves. The project will focus on three specific objectives: (1) The historiography of contested ethnic naming; (2) The memory of past violence in the landscape; and (3) The influence of intergenerational conflicts on politicization. A fourth, transversal objective will examine the feedback mechanisms between variations in the war narratives of globally dispersed communities and the conflict justifications presented by key political officials. The study will focus on wars in the African Great Lakes region, specifically those involving the pastoral Banyamulenge community. This case was chosen for three reasons: (1) Due to colonization, this community is a border population; (2) Due to past conflicts, this community has become globally dispersed; and (3) In a context of ongoing wars in the GLR, this community has shifted from a marginal to a central position in the discourses of key political officials. By integrating an outstanding international research environment and developing a tailored training program, I will qualify as a leading researcher in a new and promising field at the crossroads of political anthropology and conflict studies. Additionally, I will gain new writing, communication, and management skills, enabling me to achieve professional excellence and independence.

Mots clés : war narrative, conflicted memories, endogenous and exogenous naming, more than human approach, transgenerational conflict, feedback mechanisms, african great lakes region, north america, banyamulenge

Participants :
- Université catholique de Louvain (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 450469.44 €
- Université Clark (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of California System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- The british institute in eastern africa lbg (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Gand (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet AFRIHEAT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Heatwaves, the occurrence of extremely high temperature over a prolonged period, have been identified to cause death, reduce educational performance, weaken worker productivity, increase the risk of wildfire, and affect crop productivity. The occurrence of heatwaves has been increasing both in frequency, intensity and duration in the recent past climate and a robust increase in heatwave frequency, intensity and duration is projected in future climate scenarios. When accompanied by moist air, heatwaves can be even more lethal. During such humid heatwave (HHW) events, the physiological mechanism that allows the human body to cool down through transpiration is impaired. Previous regional research on heat stress focused mainly on Europe, South Asia, and the Persian Gulf, even though global studies also identify sub-Saharan Africa as a hotspot for heatwave extremes. Consequently, very little is known about humid heatwave occurrence and impacts in Africa due to the lack of dense meteorological networks and a consistent reporting framework. This project aims to uncover the structure, dynamics and impacts of HHW across Africa under present and future climate, and to translate this knowledge into actionable information for disaster management agencies. To achieve this objective, I will join the BCLIMATE research group under the Department of Hydrology and Hydraulic Engineering at the VUB. The host supervisor and the BCLIMATE research team have a world-leading reputation in climate extremes. Building on the tools of European Union's Copernicus Climate Change Service, the research outcomes will contribute to the forecasting of deadly heat stress across Africa and develop an early warning system to reduce HHW vulnerability. During my secondment at the UN office for Disaster Risk Reduction (UNDRR) in Brussels, I will develop an Early Warning System (EWS) to reduce on-the-ground HHW vulnerability.

Mots clés : humid heatwaves, africa, climate change

Participants :
- Helmholtz Centre for Environmental Research (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Vrije Universiteit Brussel (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
- École polytechnique fédérale de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Organisation des Nations Unies (Suisse) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet JOPHIL (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

JOPHIL will provide the first systematic study into the origins of our modern conceptions of space and void. As people living in the 21st century, we give for granted that objects are tridimensional and that void space exists in nature (or it can be produced artificially). Yet, this was not always the case. Aristotle, the great ancient thinker whose worldview remained dominant in Europe well into the 17th century, thought otherwise. He understood objects as having two dimensions only, and he resolutely rejected the idea that void space could possibly exist. The first thinker to take exception to Aristotle’s views was John Philoponus, a 6th-century Egyptian scholar writing in Greek. Unknown in the Middle Ages, Philoponus’ works were rediscovered and translated only in 15th-century Italy. Once available, they had a seismic impact on Renaissance natural philosophy and science: they provided Renaissance scholars with the tools to rethink crucial aspects of the physics of the time, and they laid the foundations of the ‘new science’ which would emerge in the 17th century. Challenging the dominant Eurocentric narratives about the origins of the Scientific Revolution, JOPHIL will map for the first time the rediscovery and progressive assimilation of Philoponus’ innovative ideas of space and void into 16th-century Europe. It will do so by examining the material recovery of Philoponus’ texts in Renaissance Italy and by exploring their impact on five European thinkers who, between 1520 and 1604, read and discussed Philoponus’ works. JOPHIL contributes to re-orient the origins of modern science in two different ways. First, it re-evaluates the role played by non-European thinkers in the shaping of European science, thus fostering a new idea of Europe as the historical product of a variety of different cultures and traditions. Second, it broadens the canon of the protagonists of modern science, thus contributing to more inclusive research and educational practices in the future.

Mots clés : late antique philosophy, early modern philosophy, classical reception, john philoponus

Participants :
- Université de Macerata (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 280202.88 €
- Université de Toronto (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Biblioteca nazionale centrale firenze (Italie) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Istituto e Museo di Storia della Scienza (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €