Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HALOBORYLATION (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This proposal describes an unprecedented, enantioselective haloborylation reaction through the innovative application of chiral anion phase-transfer (CAPT) catalysis to electrophilic-induced boronate rearrangements. Beyond the development of an orthogonal approach towards the formal trifunctionalization of alkenes, the proposed methodology provides easy access to biologically and synthetically important products, and is anticipated to have great impact in the area of diversity oriented synthesis.

Mots clés : asymmetric catalysis asymmetric borylation diversity oriented synthesis organofluorine chemistry

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171792.6 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet DLCHHB (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This proposal describes the 3D printing of hydrogel droplet networks to prepare artificial tissue-like materials that demonstrate stimulus-responsive chemo-mechanical actuation. A recent breakthrough by Prof. Bayley’s research group has enabled the 3D printing of self-supporting droplet networks which can be functionalised to allow rapid electrical and molecular communication along a specific path. As a result of this, an opportunity now exists to prepare tissue-like materials that can perform mechanical work in response to external stimuli. By printing biocompatible and responsive polymer hydrogels into droplet networks, artificial muscles will be prepared that display specific and well-defined motion. The resulting technology will be of great importance for a variety of biomaterial applications, with future European Union (EU) industrial growth as well as the public ultimately benefiting from progress in this area. This proposal is inherently multi- and interdisciplinary, involving aspects of synthetic chemistry, polymer chemistry, materials science, chemical biology and biophysics. The different expertise of Prof. Hawker, University of California, Santa Barbara (hydrogels, responsive polymers and biocompatible materials), and Prof. Bayley, University of Oxford (3D printing of artificial tissue, lipid bilayers and membrane proteins), are ideally suited for the successful completion of the proposed research objectives. Due to his prior experience and track record, the experienced researcher, Dr. Lunn, will be able to effectively drive the progression and dissemination of the proposed research. Ultimately, this project will allow one of the United Kingdom's top young researchers to spend time at one of the highest ranked materials research institutes in the world, and transfer the knowledge back to the EU via the University of Oxford. After the fellowship, Dr. Lunn will use the knowledge and skills acquired to obtain an independent academic position within the EU.

Mots clés : hydrogels, responsive polymers, lipid bilayers, 3d printing

Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226825.2 €
Projet TQCRCBL (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

This proposal describes the exploration of properties of the top quark for the study of Standard Model physics and tests of physics beyond the Standard model. Research will be conducted starting from the data of 13 TeV run of the Large Hadron Collider with particular focus on the determination of the top quark mass and other observables that might be sensitive to subtle new physics, which hides in standard searches for new physics carried out at the Large Hadron Collider experiments, in particular searches that suffer from large systematic uncertainties in the sensitive regions of phase space.

Mots clés : top quark, precision physics, new physics, large hadron collider

Participants :
- Université Catholique de Louvain (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €
Projet RMTBRC (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This proposal describes the synthesis of novel functional materials by incorporating high spin octahedral metal clusters with fascinating electronic and magnetic properties into polymeric assemblies. The resulting highly redox-responsive magnetic materials will be of great interest for a variety of applications including the storage and transfer of electrical charge, gas separation via magnetic selectivity, electrocatalysis, and long range cooperative magnetic properties will also be investigated. The experienced researcher (Dr. Musgrave) wishes to spend 24 months at Harvard University to focus on synthesis and redox activity under the supervision of Prof. Theodore Betley, and 12 months at the Centre de Recherche Paul Pascal (CRPP) to carry out magnetic measurements and data modelling under the supervision of Dr. Rodolphe Clérac. The complementary expertise of Prof. Betley (cooperative redox chemistry and catalysis) and Dr. Clérac at the CRPP (electronically active and magnetic materials) are ideally suited for the completion of research objectives. Dr. Musgrave trained in the Manners group at the University of Bristol, and has extensive experience in metallopolymer synthesis and characterisation, which is of great relevance to the project. With an MSCA fellowship, Dr. Musgrave hopes to gain valuable experience in the fields of redox catalysis and magnetic materials, build a network of long-lasting collaborations with international scientists, and improve her leadership and management skills. The fellowship will have an extremely positive impact on her chances of obtaining an independent research position in the EU, and on the success of her career.

Mots clés : polynuclear metal clusters, magnetic anisotropy, redox responsive materials

Participants :
- Harvard University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 246668.4 €
Projet IPOA (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

This proposal develops in the framework of applications of set theory to C*-algebras and it is organized into three main themes: (1) the set-theoretic study of the Calkin algebra, (2) Naimark's problem, (3) the Stone-Weierstrass problem for noncommutative C*-algebras. The first part of the project consists of a systematic analysis of the class of the C*-algebras which embed into the Calkin algebra and of how set-theoretic principles influence such class. This study will be achieved by means of forcing techniques and through the adaptation of methods coming from the framework of boolean algebras. The main objectives are to reach a deeper understanding of the structure of the Calkin algebra, and to provide a benchmark for future applications of forcing methods in a more abstract C*-algebraic context. The second part of the proposal is in continuity with the line of research opened by Akemann and Weaver in the study of Naimark's problem, and it involves a series of applications of set-theoretic combinatorial statements in the construction of nonseparable C*-algebras with peculiar properties, specifically for what concerns their representation theory. With these investigations we aim to extend, by means of set theory, the current knowledge on the discrepancies between the nonseparable and the separable framework in operator algebras. The last part of the project regards the Stone-Weierstrass problem for noncommutative C*-algebras, an old open question which asks whether the classical Stone-Weierstrass theorem can be generalized to all C*-algebras. We plan to study this topic using set-theoretic methods, with the objective to find new consistency results, and extend to the nonseparable setting the known theorems holding for separable C*-algebras.

Mots clés : mathematical logic, c  algebras, set theory, calkin algebra, forcing, naimark s problem, jensen s diamond, stone weierstrass problem

Participants :
- Université Paris Cité (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €
Projet charming-DecaDe (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

This proposal enriches the huge potential of flavour physics to discover and test fundamental properties of particle physics, by focusing on the unexplored charm flavour sector. The latter offers a unique opportunity to scrutinize flavour transitions of the up-type, and requires for this purpose urgent theoretical progress on several fronts. There will be much improvement in the charm flavour sector from the experimental side, of which the recent observation of charge-parity (CP) violation is just the beginning. As a result of exploiting available and future data, theoretical investigations of charm physics will lead to a better understanding of the Standard Model (SM), both its strong and weak sectors, and will provide new insights into the structure of its possible extensions. The first goal of this proposal is to improve the description of the hadronic dynamics in the charm flavour sector in the SM thanks to data-driven approaches, to meet the extraordinary accuracy of upcoming experimental measurements. With a better understanding of the strong dynamics, necessary to probe the weak interactions, I will design observables (branching ratios, angular distributions and CP asymmetries) having an increased sensitivity to energy scales much above the current reach of high-energy colliders. The second goal of this proposal is to probe New Physics (NP) effective operators that involve the charm flavour. By combining direct (i.e., charm-quark decays) and indirect (i.e., effects induced by quantum corrections) constraints, I will set stringent and robust bounds on NP effective operators involving charm flavour. More optimistically, rather than setting constraints, data may lead to the clear observation of NP in charm-quark transitions, which would certainly be a major breakthrough in particle physics. None of these goals has been so far fulfilled, and their importance is further leveraged by ongoing experiments that will span their range of activity over this decade.

Mots clés : flavour physics, low energy precision observables, standard model effective field theory

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 160932.48 €
Projet CARER-AID (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This proposal envisions a humanoid robot as a supervised autonomous assistant that will support caregivers in early diagnosis and improve the treatment of individuals with Autism Spectrum Disorder (ASD) associated with Intellectual Disability (ID). The robot can be part of the diagnostic team during the administration of the psycho-diagnostic tests in order to enrich the data that the psychologist can use to refine the diagnosis, helping them to distinguish among the ASD and ID levels. The robot can autonomously carry out routine rehabilitation activities that don’t need particular attention by the human therapist, who can, therefore, focus on other subjects that need more care. The robot will always remain under the ultimate control of the caregiver who can use the robot’s sensors streaming to monitor the child and intervene when needed. The proposal presents a research program that will introduce three main innovations: (i) an unique set of use cases in which a sociall assistive robot gives support to the diagnosis and rehabilitation of ASD and ID; (ii) implementation of novel control strategies for autonomous and safe robot-child interaction that can support the intelligent personalization of activities and overcome problems of the “Wizard of Oz” (WoZ) approach in practical applications; (iii) An user-centred design of the use cases that facilitates the direct integration of the robot in everyday activities and standard therapeutic protocols. The final output of the research project will be a complete set of use cases that will be empirically validated via pilot studies and small-scale trials in school, family and clinical environments. Furthermore, the proposal enlists a series of actions for the widespread scientific dissemination of the experimental results and outreach activities to give evidence also to the general public of the actual opportunities offered by robot and, thus, increase their acceptance and willingness to use robots in the care of ASD and ID.

Mots clés : socially assistive robotics

Participants :
- Sheffield Hallam University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet MadByz (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This proposal explores Byzantine medical views on mental disorders and their impact on narratives, perceptions and experiences of mental illness in the Greek Middle Ages. The Byzantine world is most notably absent from cultural and historical surveys on madness and medicine in pre-modern societies. And yet Byzantium tells us a story worth hearing. Byzantine responses to cognitive and behavioral disorders capture the biological, psychological and social complexity of mental illness resonating with the epistemic pluralism advocated by global mental health studies. By investigating how medical concepts trickle down and affect folk concepts of madness, MadByz challenges the master narrative according to which the Greek Middle Ages understood mental illness only in supernatural terms. By contrast, this proposal argues that Byzantine naturalistic understandings of mental illness are part of a cluster of different discourses on insanity, testifying to the coexistence of varied views on mental disorders. MadByz builds on the experienced researcher’s previous research in the field of history of medicine and on “madness” in ancient times, expanding his expertise and providing new training opportunities in Byzantine Greek, Narratology and Disability Studies. By offering a systematic study of a wide array of sources, MadByz is an essential stepping-stone toward a better understanding of the history and the circulation of key scientific ideas in the Middle Ages. By engaging with the entanglements and conflicts between concepts of mental disorders, MadByz also looks at the place occupied by the mentally ill within their socio-familiar and broader institutional framework. In so doing, MadByz impacts on the way we look at the past and at the present of mental illness, questioning our views and assumptions on key issues of stigmatization and institutionalization, as well as of segregation and inclusion, which are at the heart of mental health policies promoted by the OECD and the EU

Mots clés : byzantine studies, history of byzantine medicine, history of madness and mental health, disability studies, religious studies, patristics

Participants :
- University of Southern Denmark (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 328968.0 €
Projet FIT-SEP (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This proposal features a novel and inexpensive, plug-and-play ultrasensitive immune-PCR fully integrated system (lab-on-chip) that will help with early diagnosis of sepsis or toxic shock syndrome caused by pathogenic bacteria Saphylococcus aureus and Streptococcus pyogenes. Sepsis kills 5.1 millions of people annually; it has up to 26% mortality and rapid progression. S. aureus and S. pyogenes colonise ~50% healthy individuals, and cause common diseases such as tonsillitis, skin and deep tissue or medical implant infection, which sometimes progress to sepsis. Biomarkers that predict of S. aureus and S. pyogenes-caused sepsis are bacterial toxins, superantigens. S. aureus causes most deaths from infectious diseases in high-income countries. This situation is exacerbated by spread of multiple antibiotic resistant S. aureus (MRSA) in the community and hospitals. Superantigens are commonly found in the serum in the absence of bacteremia. It is hence not appropriate to detect them by PCR of the toxin-coding DNA sequences. The key to our innovation is detection of superantigen protein using novel DNA-containing detector nanorods. Binding of the detector particles to the analyte will be quantified via the nanorod DNA. This strategy (immune-PCR) combines immunodetection with sensitivity of PCR to achieve ultrasensitive detection. The system devised in this action will be a prototype for a novel class of devices for ultrasensitive detection of wide array of molecules, including explosives, hormones, or chemical pollutants. The affordable all-in-one plug and play design will allow use in the general practitioner’s office (point of care), at home, or even in the war zones or disaster areas. Development of fully integrated point-of-care lab-on-chip prototype will require multidisciplinary effort where ER’s novel detector nanorods will be combined with the Eden’s expertise in design and engineering of microfluidic systems.

Mots clés : biological nanoparticles, phage display, in vitro diagnostics, point of care

Participants :
- Eden tech (France) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 196707.84 €
Projet OCEANURB (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This proposal investigates the ocean as a spatial realm and the site of unfolding urbanization processes- a challenging new field within urban studies. The project aims to, 1. promote a holistic, inter-disciplinary view of the ocean which connects its geo-physical, biological and socio-economic dimensions through spatial means. Rather than a peripheral realm, or a void, the ocean is placed at the geographical and epistemological centre of current territorial developments, which represents a paradigm sift in perspective and is beyond the state of the art. The project proposes methods of spatial analysis that enable the invisible urbanization processes in ocean space to be represented, evaluated and shared as data to a range of stakeholders and academics- a new contribution to urban theory. 2. Support theoretical reflections by producing a case-study on current urbanization processes in the North Sea, in collaboration with a territorial study of North Sea settlement led by the supervisor’s chair. The two-way transfer of knowledge takes place across the land-sea threshold, demonstrating how the greater sea-space has influenced urban development. The North Sea project achieves a continuity of analysis across the interlocking land- and sea-sides – something that has never been achieved at the scale of the Sea as a whole and therefore stands to rewrite understandings of regional urbanization. 3. Critically examine and theorize the contradictory spatial dimensions of maritime transport as a sub-topic- although the backbone of globalization, consuming increasing on- and offshore areas, carrying increased loads, shipping’s spatial typologies are elusive, lacking architectural quality and interaction with urban contexts. Through the project the researcher will profit from first-hand experience and exchange with the European hub of maritime trade and an excellent research environment, gaining new specialist knowledge in the field which is applied to enrich urban research.

Mots clés : territory, seascape, maritime trade, globalization, infrastructure, transboundary, marine spatial planning, ocean space, planetary urbanization

Participants :
- Delft University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 133199.1 €
Projet PaGHEMMo (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This proposal investigates the original meaning and uses of the particles án and ken in the earliest Greek texts (epic and lyric poetry and inscriptions, VIII-VI BC, there are no examples in Mycenaean, XIII BC) and their interaction with mood and modality, the use of the particles man, san and kan in the Old-Hittite texts (1650-1450 BC) and the comparison between the particles in Greek and Hittite, and to what extent the subordination plays a role in the use of the Greek particles. The use of the modal particle án with the different moods is strictly regulated in Classical Greek (V-IV BC), but epic and lyric Greek, and other dialects án, use ken or ka, and the rules seem less rigid. So far no study addressed the use of these particles in the oldest Greek texts. I gather the data, determine if they are secured by the metre, tag and catalogue them per tense, mood, type of sentence (negative, affirmative, main clause, subordinate and type of subordinate clause) and type of text (narrative, speech) and analyse the use(s). While Greek has a rich system of moods and particles, Hittite has only two moods and conveys the non-realis meaning through the particle man, but also san and kan can specify the verb. Kan is said to be related to ken and becomes the default particle in later texts replacing san, but in Old-Hittite texts san is more common. The original meaning of san and kan is debated. I gather the instances of kan and san, catalogue them per text and sentence type, and investigate the meaning. Then I compare the use of these particles with verbs to Greek ken. Finally, I investigate the link between the Greek particles and subordination. The particles are attested more in subordinate than in main clauses and in some subordinate clauses they are used more often than in others. There are two questions: were the particles used as subordination markers or can the paratactic origin of the subordinate constructions explain their use.

Mots clés : epic greek, historical syntax, indo european, hittite, historical linguistics

Participants :
- University of Verona (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171473.28 €