Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet REFUDEPRE (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

REFUDEPRE will take a mixed-methods approach to understand the burden of postpartum depression on refugee women and their offspring and shed light on the role of home visiting programs lead by health nurses to support the mental health of refugees after giving birth. Postpartum Depression (PPD) is the most common mental health disorder after birth, and refugee women are at increased risk of developing it. When untreated, PPD can interfere with the mother’s ability to care for her baby and thus impact the development of the child. However, no research to date has studied these links among refugees, who are also exposed to other social risk factors that affect both maternal and child health. Besides, few studies have investigated refugee mothers’ mental health needs after pregnancy, and evidence on psychosocial interventions that support such mental health needs is lacking. Building on the analysis of the Danish Child Health Database (CHD), and qualitative interviews to refugee and health nurses participating in the innovative Health Nurses Strengthen integration, the Danish home visiting program for refugee families, I will be able to fill these gaps. Given the increased flow of refugees in Europe, results will be both academically relevant and informative to the design of public health programs and policies aimed at reducing mental health inequalities in refugee groups. I will significantly benefit from a placement at the Research Centre for Migration, Ethnicity, and Health (MESU) at University of Copenhagen as it congregates experts in the field of immigrant and refugee health connected to a large network of international researchers and policymakers. With the support of the MSCA fellowship, I will also acquire skills in using large national and register databases and will be able to apply my expertise in qualitative methods to unpack the mental health benefits of home visiting for refugee women.

Mots clés : mental health, postpartum depression, refugees, immigration, early childhood, nursing, health inequalities

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 219312.0 €
Projet REMEDI (Horizon 2020, appel à projets 2020)
Action : Doctoral Networks - Industrial Doctorates
Panel : Environment and Geosciences
Statut du projet : SIGNED

REMEDI trains future professionals and scientists in the area of competitive use of water resources within an industry centered environment, targeting the problem of scarcity of water resources due to contamination by pharmaceuticals. Enhanced loading of water resources with pharmaceuticals is a key challenge in meeting the objectives of the EU Water Framework Directive. Iodinated X-ray contrast medium agents (CMA) are one type of the pharmaceuticals being used for the imaging of soft tissues which are typically administered in elevated doses for each imaging operation and excreted mainly nonmetabolized. The CMA are persistent during conventional biological wastewater treatments and therefore, CMA have been detected at elevated concentrations in the effluents of waste water treatment plants, surface waters, groundwater, and even in drinking water. Tauw GmbH is an environmental company which recognizes that design of strategies for treatment of water resources requires solid knowledge leading to new methods and approaches to trap pharmaceutical components in water treatment systems and in the sediments of lakes and rivers. Tauw GmbH does not have in-house resources to undertake the body of research required to set and develop. It has stimulated the REMEDI EID action, jointly with Politecnico di Milano and University of Warwick, to address these issues. Trapping of CMA involves the application of iron(Fe)- containing by-products from drinking water treatment. REMEDI aspires the ideas of a circular economy and aims at recovering the retained X-ray Contrast Media agents in water treatment systems, rivers and lakes. Novel technologies will be developed to convert CMA-loaded Fe-minerals into marketable products whose suitability will be evaluated. 5 ESR projects address these challenges with a level of interaction and synergy among academic and non-academic players leading to forming a cadre of scientists with skills apt to unravel complex environmental scenarios.

Mots clés : pharmaceutical related contamination

Participants :
- Politecnico di Milano (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 522999.36 €
- Tauw gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 421314.0 €
- University of Warwick (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 404230.08 €
Projet RENOIR (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

RENOIR is a European Training Network that brings together 12 beneficiaries (10 academic and 2 industrial), and 3 partner organizations (a private Onlus Foundation, a pharmaceutical company, and a university) to train 13 Early Stage Researchers with an interdisciplinary profile for outstanding carriers as leaders in the field of muscle regeneration and aging. Receiving a training programme in both scientific and transferable skills and using unique expertise and tools at the frontier between biology and engineering, this new generation of versatile researchers will dissect the cellular and molecular mechanisms underlying impaired muscle composition and function, paving the way to new therapeutic interventions for muscle disease and aging. This will happen through collaborative and synergistic projects between academia and industry.

Mots clés : muscle regeneration, innate immunity, host microenvironment, cell identity, epigenetics, biopharma, biomaterials, microfluidics, live imaging, bioinformatics

Participants :
- Pompeu Fabra University (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 76665.38 €
- Université Paris-Est Créteil (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 174193.96 €
- University of Naples Federico II (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 261499.68 €
- Eden tech (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 549604.08 €
- National Research Council (Italie) — Partner, beneficiary, Recherche, subvention : 261499.68 €
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Partner, beneficiary, Recherche, subvention : 261499.68 €
- Cherry Biotech (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Manchester (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
- University of Milano-Bicocca (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 261499.68 €
- Technion – Israel Institute of Technology (Israël) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 263500.92 €
- Hmgbiotech srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 261499.68 €
- University of Debrecen (Hongrie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 229715.28 €
- Université Claude Bernard - Lyon 1 (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274802.04 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
Projet RESHORE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

RESHORE is an action research project which will investigate the potential and limits for manufacturing in Europe as part of a social economy fit for the future. In spite of decades of offshoring and a global race-to-the-bottom, manufacturing remains a significant part of the European economy, employing around 30 million people. Given increasing evidence of the vulnerabilities and unsustainabilities resulting from over-reliance on global supply chains, especially in a post-Covid context, RESHORE will enhance our understanding of how emerging and established European manufacturers operate and thrive, influencing discourse on sustainable economic transformation in the EU. Theoretically and methodologically grounded in economic geography, the project will take a comparative approach to learn from existing initiatives in reshoring manufacturing in Germany, Italy and the Czech Republic. The objectives of RESHORE are: 1. To advance a ‘diverse economies’ analytical framework for understanding the equitable relocalisation of European manufacturing; 2. To outline participatory pathways for local manufacturing in three EU Member States, drawing from interactive visioning workshops; 3. To identify the geographical influences for equitable reshoring transitions through empirical case studies. To achieve these objectives, and influence public debate on issues relating to reshoring, the project will combine conventional qualitative methods (ethnography, semi-structured interviews) with transdisciplinary, action-research approaches. A structured and comprehensive plan for training in transdisciplinary methods will enable the fellow to reach professional maturity and secure a group leader or permanent faculty position at a world-leading European research institution. This project will be hosted at LMU, Munich, and includes a secondment at the European Research Institute on Cooperative and Social Enterprise (EURICSE), Italy.

Mots clés : social enterprise, solidarity economy, just transitions, geography, degrowth, production, ecological economics, community economies, qualitative, action research, participatory, transdisciplinary

Participants :
- Ludwig-Maximilians-Universität München (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162806.4 €
Projet REVIEW (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

REVIEW – REVealing hIddEn Wall paintings – is a MSCA Individual Standard European Fellowship with the scope to adopt non-destructive multispectral imaging techniques for the detection of covered wall paintings, hidden structures and unseen damages in Cultural Heritage. Therefore, the researcher, Max Rahrig, will combine active and passive thermography in the spectral ranges of long- and mid-wave infrared (LWIR and MWIR) with ultraviolet-visible-near-infrared (UV-VIS-NIR) imaging, 3D laser scanning and photogrammetry. The Photogrammetry and Laser Scanning Research Group (GIFLE) of the Universitat Politècnica de Valencia (UPV) in Spain will host REVIEW under supervision of Professor José Luis Lerma. Several examinations and tests on case studies will help to develop innovative guidelines for a reproducible and adoptable workflow with high-end multispectral imaging techniques rarely unified in current documentation and assessment practices. The surveys are located at several heritage sites in Valencia, including the Cathedral of Valencia, Basílica de la Virgen and/or Church of San Esteban, followed by the transfer of the approach to the UNESCO World Heritage Site Rangiri Dambulla Cave Temple in Sri Lanka. In Dambulla the investigations serve to reveal large areas of concealed wall paintings and to detect areas threatened by climate damages (high water intake through the rock). The results will be a basis for a follow-up project to protect and conserve the World Heritage Site. The innovative research approach of REVIEW will be ready to be transferred to a large number of historical objects to help conservation users with easy-to-use, comprehensive and outstanding technological solutions for their examination, conservation and dissemination of hidden wall paintings.

Mots clés : ndt for cultural heritage, multispectral imaging, preventive conservation, active thermography

Participants :
- Universitat Politècnica de València (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160932.48 €
Projet dCas9 (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

RNA polymerase II (RNAPII) transcribes protein-coding genes in eukaryotes. The proper RNAPII transcription termination is crucial for generation of functional mRNAs, and then proteins. Termination, or stop of RNA synthesis, may occur before or after mRNA 3’-end cleavage and polyadenylation. In the last decade many details have been acquired about mRNA maturation, but still little is known about the termination per se. In this proposal I will redress this problem. One of the proposed transcription termination triggers is RNAPII elongation complex pausing downstream of mRNA maturation signal. I will test this hypothesis, using sequence-specific protein binding in the living cells. In the proposed project I will combine cutting-edge CRISPRi/dCas9 technology with classical molecular biology, high-throughput sequencing and computational biology. This approach will allow me to address my research objectives: (1) to elucidate the role of elongation complex pausing in transcription termination and (2) to characterise the induced pausing in terms of stress-resistance. Also by implementation of this project I will develop a bioengineering tool to induce elongation complex pausing. This timely approach, taking advantage of innovative technologies, will allow me to elucidate previously unknown details of RNAPII transcription termination in mammals and expand our knowledge about this process. Importantly, my approach will allow studies on the chromosomal genes in the living cells, making the results unique and valuable. Implementation of the proposed project will enhance my proficiency by improving and diversifying my skills in experimental and computational science as well as boosting my transferable skills, such as scientific communication and writing, project management and networking. This altogether will improve my competitiveness and potential on the way to independent career. Thus the proposal corresponds well with the aims of the Work Programme.

Mots clés : rnapii, transcription termination, protein coding genes, mrna

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet meltRBP (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

RNA-binding proteins (RBPs) are among the key players in post-transcriptional gene regulation. A detailed knowledge of the RBPs bound to a specific RNA target is critical to the unravelling of the regulatory steps of RNA expression under normal and disease conditions. However, the study of these interactions is complex and requires methodologies that go beyond the scope of individual RBPs. So far, the techniques have been confined to post-lysis protein or RNA enrichment, which limits the identification of non-abundant targets and often relies on the insertion of tags. To solve these issues, thermal proteome profiling (TPP)—relying on the stabilisation of the endogenous protein through the binding of its ligand—will be applied in this project. Here, using mass spectrometry, TPP will be applied to investigate complex RBP-RNA interactions on a proteome-wide level in an unbiased manner ('meltRBP'). First, the methodology will be benchmarked with the help of a well-characterised interaction: the iron regulatory proteins and their RNA target, the iron response element (IRE). Secondly, TPP will be applied to a biologically relevant system, namely the mRNA of the Amyloid Beta Precursor Protein (APP). The proteolysis of mutant APP proteins, which are generated from alternatively spliced mRNAs, generates highly aggregation-prone β-amyloid peptides, a hallmark of Alzheimer’s disease (AD). The application of TPP to identify RBPs bound to the wild-type versus mutant APP mRNA will reveal new potential targets for AD treatment. Finally, TPP will be used to determine the specificity of the hybridisation of antisense oligonucleotides (ASOs), currently of great interest to the field of neurodegenerative disease treatment and whose global cellular effects have thus far not been investigated in a high-throughput manner. In summary, this proposal encompasses the benchmarking and application of an innovative proteomic technique, that has the potential to function as a screen for ASOs.

Mots clés : thermal proteome profiling, post transcriptional regulation, antisense oligonucleotide screen, alzheimer s disease

Participants :
- European Molecular Biology Laboratory (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 171460.8 €
Projet PersVR (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Raising awareness and comprehension of global problems such as climate change or refugee movements provides a communicational challenge, as these problems often stay abstract and distant to people. With the advent of virtual reality (VR), academics and journalists alike put their hope in 360º-video VR stories as a potentially revolutionary tool to create scenarios that make these problems more graspable, thus raising concern and instigating attitude-change. However, to date, empirical insight into potential persuasive effects of 360º-video VR stories is almost absent, and theoretical conceptualizations of how they might impact people are lacking. PersVR is going to change this. The aim of PersVR is to overcome these shortcomings, and to demonstrate if and how immersive journalism and documentary focusing on 360º-video VR might affect people’s beliefs, attitudes, and behavior. The project adopts a multidisciplinary perspective that integrates knowledge from different fields (including social psychology, communication sciences, and psychophysiology) into a theoretical model that describes how narrative and immersive attributes of 360º-video VR lead to persuasive outcomes. The empirical testing of the model will utilize an innovative combination of self-report, psychophysiological, and behavioral methods to comprehensively illuminate the psychological mechanisms involved. The complex set of methods deployed will permit to determine optimal methodological standards that promise to guide future related studies. The current rise of “immersive journalism” and VR storytelling accentuate the high relevance, timeliness, and expected impact of the project. The innovative approach of the project and the envisioned collaboration with the host will provide the applicant with a unique research profile and significantly advance his striving for an independent career at world-leading research centers dedicated to illuminate the social impact of new VR technologies.

Mots clés : media psychology, virtual reality, immersive journalism, immersive media, persuasion, attitudes, psychophysiology, 360  video

Participants :
- Vrije Universiteit Amsterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175572.48 €
Projet Christianus Arabicus (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Ramon Llull’s Cent noms de Déu is the only versified work which entered the net of self-quotations and self-references which Llull used to promote and advertise his own production as a new alternative to his contemporary science and literature. In spite of his condemnation of troubadour lyric in his Book of Contemplation, Llull wrote many poems with a mnemonic-didactic purpose related to the learning of his epistemological system, i.e. the Art. Yet some his poems and some of his literary works are strongly related with contemporary literature and literary uses which he exploited and transformed to attract a wider audience. These literary ‘traps’ were a useful tool to spread the Art among all social classes, thus enhancing the fulfilment of Llull’s project: the conversion of all the unbelievers. The new critical edition of this work will help advancing my research on why Llull used poetic forms albeit he despised them and will provide new materials for understanding the circulation of culture and of ideas in the Mediterranean area in the XIII-XIV centuries. The outcome of this project will be a new critical edition of the text and a series of deliverables in which I will deeply analyse the context and co-texts of the poem, thanks to the expertise of the centres involved. Through this I will contribuite new material to philosophy/theology by investigating the Christian and Islamic interpretations of God's Names, to literary history understanding why Llull gave such an importance to a work which is not actually a proper poem but rather versified prose, analogous to the Arabic saj’ and to the early Office of the Hours' liturgical text, to linguistics by analysing the degree of Occitanisation of this work and in general of Llull’s poetry to understand how far his poetic language is from the abhorred troubadour lyric, finally to musicology by examining how this work was chanted, thus showing the interdisciplinary and cross-boundary value of Llull's production.

Mots clés : ramon llull, names of god, medieval poetry, medieval philosophy, medieval theology, romance philology, medieval latin, translation studies, islamology, musicology, cognitive philology

Participants :
- University of Barcelona (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 158121.6 €
Projet EPNRL (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Random lasers based on disorder and multiple scattering are alternative means to generate laser light. Although random lasers have been studied for over thirty years, very few practical applications utilizing random lasers have been realised. The main difficulty with random lasers has been achieving electrical pumping with high conversion efficiency and obtaining directional beam output. Resolving these difficulties will make random lasers practical and will open up many new applications, such as in optical computing and image projection. In this project we propose to develop an electrically pumped network random laser. This new type of laser will have high conversion efficiency and directional beam output, and can be easily integrated on a chip with waveguides. This project is at the cross-roads of nanophotonics, complex systems and network science, and thus is quite multi-disciplinary in nature. Results from this project will be technologically significant and will enable rapid commercialisation of random lasers, which has thus far been limited.

Mots clés : random lasers, network lasers, semiconductor laser diodes, photonic integration

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €