Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HydroTheC (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Ovarian Cancer (OC) is usually diagnosed in advanced stages when metastasis into the intra-abdominal (i.a.) cavity already occurred. The OC standard-of-care efficacy is hampered by drugs high systemic toxicity and the early appearance of resistance. Thus, advanced OC remains an unmet clinical need, forcing the need for alternative therapies based on drugs local slow-release at the i.a. cavity. Hydrogels (HG) have been proposed as in situ drug sustained release systems in the biomedical field. Their application avoids off-target effects caused by drugs systemic administration and improves their therapeutic efficacy. Thermo-responsive HG (TR-HG) gained special attention due to their ability to be liquid at room temperature, enabling their injection, and jellify at body temperature. Accordingly, the goal of HydroTheC is to provide a new on-demand TR-HG as a new delivery depot system for the impairment of OC i.a. spread. The innovative character of the proposed HG relies on: i) Use of Natural and eco-friendly components and synthesis methods recognized by Green Chemistry rules, ii) Use of in silico bioinformatic tools to reduce unnecessary expenses and environmental impact, iii) Nanoparticles incorporation to create e multicompartment HG system, and iv) On-demand character, due to its easy adaptability to any drug or clinical conditions that would benefit from local therapy. For the project success will be crucial the team interdisciplinary character, as well as the perfect match of knowledge existent between the candidate and associated institutions. In the end, it is expected to obtain a novel HG that will significantly increase the standard-of-care therapeutic window, increasing OC patients survival and quality-of-life. Moreover, the designed HG would serve as a technological platform adaptable to different clinical applications, paving the way toward more personalized therapies, and bringing new alternatives to clinical situations with limited therapeutic options.

Mots clés : drug delivery, hydrogels, local therapy, cancer treatment, green chemistry, in silico tools, nanomedicine

Participants :
- Université d'État du Kansas (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Universidad de Talca (Chili) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- CERCA Institution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 221390.88 €
Projet HOT-HYGEN (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The project aims to comprehensively study the high-temperature oxidation behaviour of NiCr and FeCr alloys with alloying additions of e.g., Ti, Mn and Si in the wet/hydrogen-containing atmospheres with emphasis on the growth mechanisms and failure of surface Cr-oxide scales. While these materials have been well-studied in oxygen and air, their performance in the atmospheres than can be encountered in hydrogen power plants and fuel cells, remains unexplored. This research is therefore relevant to the ongoing transition towards hydrogen as a sustainable energy source. Understanding how Ni- and Fe-based materials behave in such conditions is essential for developing more efficient and durable components for power generation. The project will utilize a combination of thermodynamic modeling (ThermoCalc, FactSage) and advanced experimental techniques, including e.g., oxidation testing, Scanning Electron Microscopy, X-Ray Diffraction and TEM/APT (Transmission Electron Microscopy/Atom Probe Tomography). The use of correlative TEM/APT will enable the study of grain boundary diffusion and selective oxidation, providing insights into fast diffusion pathways and oxidation mechanism at the atomic level. Oxygen isotopes will also be used as tracers to allow for quantitative analysis of the elemental distribution providing unique insights into the oxidation mechanisms, crucial for correlating microstructural features with oxidation kinetics and identifying the role of minor elements in material degradation processes. The research will be conducted in an iterative approach, refining theoretical models based on experimental findings to optimize alloy compositions for high-temperature, hydrogen-rich environments. This comprehensive approach will not only advance the fundamental understanding of oxidation processes but also contribute to the development of materials for hydrogen applications, supporting the EU’s green energy transition and reducing CO2 emissions.

Mots clés : high temperature oxidation, nickel alloys, ferritic steels, hydrogen atmospheres, grain boundary diffusion, atom probe tomography, thermodynamics, modeling, energy sector, oxidation kinetics

Participants :
- Forschungszentrum Jülich (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 202125.12 €
Projet REACTIS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Adapting to the increasing threat of natural hazards is one of the most pressing current societal issues. Specifically, seismic risk reduction and adaptation of complex intertwined industrial facilities are keys for an effective EU green transition. Nevertheless, the most common policies still rely only on static risk analyses, neglecting temporal and spatial interactions. In fact, no one has yet tackled the critical aspect of industrial system adaptation, accounting for the dynamics of the hazard, of the system itself and its recovery processes. This comes with no surprises, as system adaptation is a highly complex stochastic process, deeply rooted into the future, where uncertainties at all levels play a crucial role. This critical research gap is filled with the “Seismic Risk Reduction and Adaptation for Complex Time-dependent Industrial Systems” (REACTIS) project, which is the first integrated uncertainty quantification (UQ)-based methodology that aims to solve these open questions. The project will examine the stochastic dynamics of the performance of industrial facilities subjected to time-variant seismic hazards. In particular, the recovery processes of the systems will be deepened and treated from a UQ and stochastic dynamics perspective. Building upon preliminary collaboration, the project will focus on the stochastic dynamics and recovery of a single 1-node system. Then, a real-world complex industrial case study will be deployed. Leveraging concepts from spatial statistics and graph theory, the intertwined network topology of the industrial system will be mapped. Specifically, the evolution of the dynamics of the system will be extended to a m-nodes, initially deterministic, then random, network configuration. Finally, our research will encompass an in-depth analysis of seismic risk and adaptation strategies formulation. This effort aims to identify the criticalities and vulnerabilities within the industrial system networks.

Mots clés : complex network systems uncertainty quantification industrial facilities stochastic dynamics seismic risk adaptation strategies disaster risk reduction seismic hazard and vulnerabilities

Participants :
- Université de Trente (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 297164.16 €
- École polytechnique fédérale de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PINPOINT-NMR (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The cell is an ensemble of dynamic molecular machines. NMR spectroscopy is the method of choice to observe complex conformational changes, transient interactions, and dynamics of proteins at atomic resolution. The introduction of methyl-specific labeling has made it possible to study protein assemblies of several hundred kDa by solution NMR. However, the high number of overlapping signals and the labor-intensive process of site specific analysis hamper NMR investigation of large hetero-oligomeric assemblies at room temperature. While segmental labeling or site-specific labeling offer opportunities to simplify 2D NMR spectra, the complexity of sample preparation or the characteristic low expression yield drastically limit its subsequent applications. Therefore, efficient, widely applicable, and straightforward labeling strategies are necessary to integrate solution NMR analysis of large proteins (such as monoclonal antibodies) into R&D pipelines for biomedical industry. I propose to harness the natural (anti)codon code for multi-site, sequence-specific isotope labeling. The resulting method would simplify the spectral congestion typical of 2D NMR spectra of large proteins, allowing targeted investigation of sites of interest (e.g. catalytic centers) and streamlining residue assignment. This method will reduce the time required for residue specific analysis of NMR data from months to days, thus expanding our ability to study large, medically-relevant complexes and address current biological challenges.

Mots clés : protein, nmr, nuclear magnetic resonance, isotopic labeling, methyl, cell free, trna, assignment

Participants :
- Université Grenoble Alpes (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 283025.7 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Sanofi-aventis R&D (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet SIGN-IT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The “SIGN-IT – Signacula in Roman and Post-Roman Italy: marking religious and cultural identity (2nd-11th c. CE)” project aims at studying the cultural history of the Italian peninsula from the Roman Imperial period to the central Middle Ages, by means of the objects known as signacula, i.e. matrices bearing text, signs, and/or iconographic motives, designed to stamp various materials. Linguistic choice is one of the main markers of identity : thus, the project focuses on materials found or originally coming from a sample of Italian regions featuring both Latin and Greek speaking communities: Veneto, Emilia-Romagna, Campania, Apulia, Calabria, Sicily, and Sardinia. The historical value of this body of evidence has been hitherto largely neglected due to its difficult dating. To overcome this issue, I will study for the first time the corpus as a whole, from Antiquity to the Middle Ages. The project’s objectives are three-fold: firstly, to establish a clear dating protocol for the signacula to unlock their full potential as historical sources; secondly, building on the newly-dated material, to study the evolving linguistic patterns, and their contribution to the making of specific local identities, between Antiquity and the Middle Ages; thirdly, to track over the “longue durée” changes in marking practices and to analyse them as proxies for cultural transformations. To achieve these goals, I will build up an open-access database gathering published and unpublished signacula pertaining to the chronological and geographical framework under scrutiny. The database’s structure will allow both qualitative and quantitative analysis of the material, and will facilitate comparisons with other types of stamped writing and of inscribed objects (e.g., seals), by adopting and building upon the technical features and norms of the Text Encoding Initiative standard (TEI, https://tei-c.org/), developed for the digital edition of ancient inscriptions (EpiDoc) and seals (SigiDoc).

Mots clés : digital humanities sigillography archaeology social practices religious and ritual practices linguistic practices inscribed material culture

Participants :
- Université de Cologne (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École française de Rome (France) — Coordinator, beneficiary, Recherche, subvention : 172750.08 €
Projet MobileWorlds (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The overall goal of MobileWorlds is to explore pathways to better integrate socio-cultural diversity into today's institutions, so they may better deal with contemporary challenges of sustainable mobility and societal inequalities. Such pathways are sought by engaging explicitly with third culture experiences to identify concrete diverse imaginaries and allowing these to feed into equally diverse solutions that can realistically be implemented. Third cultures are unique cultures that emerge from contact with different home and contextual cultures during the formative years of an individual. These third cultures are increasingly common in a globalising world, and may have important repercussions for imaginaries for sustainable and just mobility futures. As such, they provide promising sources for pathways that integrate socio-cultural diversity into today's institutions. Bergen, Norway and Porto, Portugal are known for cultural diversity and advancement in sustainable mobility. Combined, they provide both a Northern and a Southern European perspective and a particularly interesting context within which to research this subject. MobileWorlds delineates four key objectives: (1) To solidify and expand the concept of third cultures, (2) To develop methods and methodologies that encourage artistic engagement of all ages and socio-cultural groups in mobility planning, (3) To engage communities in mobility planning through arts-based events and activities, and (4) To support my future career development through arts-based research and engagement training and expanding academic and artistic networks and experience. The hands-on experience and training will help to accomplish my career goals securing an Assistant Professor position in the field of Mobility Planning or working in public engagement for an NGO promoting sustainable mobility. With such a position I hope to contribute to improve the sustainability and justice of the world through diverse and inclusive approaches.

Mots clés : third cultures, social inclusion, pluralist imaginaries, sustainability, mobility

Participants :
- Collège universitaire du Vestland (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226751.04 €
Projet DISCEFRN (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Around 57 million people in Europe are foreign-born. Developing strategies for inclusive growth and devising actions to promote immigrant integration through non-discrimination are among Europe’s current priorities. This project will evaluate if the Common European Framework of Reference for Languages (CEFR), which is used to standardize host country language requirements for different professions throughout Europe, can serve as an effective tool to reduce hiring discrimination against immigrants. Employers have been shown to discriminate against immigrant applicants based on language-related bias, which can be reduced when language requirements are specified in CEFR terms. Based on a novel design that combines real-world variation in the inclusion of CEFR requirements in job ads with a factorial survey experiment and in-depth interviews among employers, the project will address three objectives: 1) Examining if the inclusion of CEFR requirements reduces differential treatment of immigrant applicants on aggregate; 2) Identifying labor market areas and ethnic groups that benefit most from the introduction of CEFR requirements; 3) Assessing the current implementation of CEFR requirements in relation to uninformed or inadequate use. Results and the collected data set will be distributed among the scientific community (open access), among the general public (science fairs) and among employers and county governors (webinars, roundtable discussions) and can serve as a stepping-stone for developing comprehensive and adequate language requirements for different professions at the (inter)national level. The projects unites expert researchers in sociolinguistics and language test development with an early career researcher (ecr), specializing in immigrant integration and language-based discrimination into an interdisciplinary team. This will provide impactful training to the ecr, who will benefit from methodological training, project management experience, and network ties.

Mots clés : anti discrimination strategy, ethnic discrimination, ethnic inequalities, immigrant and refugee integration, 

Participants :
- Collège universitaire du Vestland (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 140607.36 €
Projet IMEI (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

An important element of social cohesion and contact between majorities and sub-state ethnic minorities are intermarriages, which are either welcomed as vehicles easing the tensions between nations and sub-state minorities, or criticized as important drivers of assimilation and the ‘destroyers’ of ethnic minority communities. The social aspects, family dynamics and identity construction of family members in intermarriages were not studied methodically in CEE and the WB. Therefore, the goal of the Intermarriage and Ethnic Identity (IMEI) project is to analyse the social implications of intermarriages between members of ethnic minority communities and the majority nations in Vojvodina, the multiethnic region of Serbia. The IMEI project will contribute to the state-of-the-art by analysing the social impacts of intermarriages on three levels, namely the individual (micro), the family (meso) and the societal (macro) in a significantly multi-ethnic geographic region. On the individual level the project will examine ethnic and cultural identity transformations undergone by partners in intermarriages. On the family level we will explore the processes of intergenerational transfer of ethnic, religious and cultural markers. On the societal level the project will investigate the workings of the relevant and quite modern ethnic minority policies and legal framework of Serbia and their impact on intermarriages. This research is relevant in the wider European context as well, as we will specifically target the Hungarian, Slovak and Romanian ethnic minorities living in Vojvodina, whose kin-states (Hungary, Slovakia, Romania) are members of the European Union, whose members often have dual Serbian and EU citizenship and are therefore subject to the Framework Convention for the Protection of National Minorities and European Charter for Regional or Minority Languages, the European Union’s key policies for the protection of (its) minorities.

Mots clés : intermarriage, sub state ethnic minorities, gender, acculturation, identity transoformations

Participants :
- Université Loránd Eötvös (Hongrie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 157622.4 €
Projet AlgalBB (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Currently, Dairy Wastewater (DW) is seen as a major global problem, difficult and expensive to treat and potentially very harmful to the environment as it contains high amounts of organic and inorganic content. The current treatment methods (physicochemical and conventional) are energy-intensive and don’t sufficiently remove the nutrients. But, with the high amount that is produced worldwide: 0.2‒10 L wastewater/ L of milk processed; this is potentially a valuable resource that, if utilized appropriately, can provide high-value green chemicals and biofuel. Therefore, a new cost-effective method for the treatment of DW along with the generation of valuable biomass needs to be developed. In this context, AlgalBB proposes the concept of biorefinery for the substantive treatment of DW via microalgae, coupled with biodiesel and bio-succinic acid (SA) production. These objectives will be pursued through 1) The designing of a microalgae consortia that can remediate DW to achieve a zero-waste process and generate lipid/carbohydrate-rich algal biomass; 2) The green synthesis of magnetic nanocatalyst for developing a low-cost, efficient method for in-situ transesterification for wet algal biomass to produce biodiesel; 3) Development of multienzyme magnetic nanocatalyst for efficient enzymatic hydrolysis to recover fermentable sugars from algal biomass; 4) Immobilization of fermentative bacteria for fermentation of sugars into SA. The interdisciplinary AlgalBB will apply cutting edge biology tools to complete the aforesaid objectives. AlgalBB adopts a circular economy approach that directly addresses clean water, clean energy; actions established by the EU Horizon Work Programme and will support the competitiveness of European biorefineries. The acquisition of transferable skills through AlgalBB will increase my employability in industry and especially in academia, allowing me to establish myself as an independent researcher and reach a professor position within 5-10 years.

Mots clés : microalgae, dairy wastewater treatment, bio succinic acid, biodiesel, fermentation, in situ transesterification, magnetic nano catalyst, immobilization

Participants :
- Université norvégienne pour les sciences de la vie (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226751.04 €
Projet Q-WAVE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

The circulator, a cornerstone in communication and radar engineering, has gained importance in quantum technologies, becoming essential for reading out superconducting qubits. Q-Wave (Hybrid Quantum Wave Circulation) aims to transform current 3D cryogenic circulators into 2D devices, free of permanent magnets. This new generation of circulators can be integrated on-chip, close to the quantum processor, therefore contributing to the scalability of superconducting quantum computers. The realization of such devices would mean an important reduction of the volume of critical raw materials or less efficient alternative solutions, in agreement with the objectives of the European Green Deal and the Sustainable Development Goals.  Q-Wave’s sub-goals are: O1) design tuneable superconducting (SC) resonators; O2) study magnon-photon interactions in magnetic vortices; O3) develop on-chip circulators compatible with magnetic field operation; O4) develop self-biased on-chip circulators without external magnetic field compatible with SC circuits. For that, the project combines complementary unique abilities in hybrid systems (Associated Partner, AP, EPFL, Switzerland); quantum magnonics (Host Institution, HI, CSIC, Spain); CMOS (Complementary Metal-Oxide-Semiconductor) and SC circuits (fellow) and classic magnonics (secondment, University of Vienna, Austria).

Mots clés : superconducting circuits, superconducting resonators, magnonics, vortex, magnetic textures, magnon photon coupling, circulator, non reciprocal devices, scalable quantum computing

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 389156.16 €
- Université de Vienne (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École polytechnique fédérale de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €