Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Multi-RM-6GIoT-GAI (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The Internet of Things (IoT) has fundamentally changed our interaction with the physical world, bringing a paradigm shift that has transitioned physical objects into digital and interconnected devices. This digitalization revolution largely hinges on to take a significant leap forward with the deployment of emerging 6G networks. While 6G holds great promise, it also poses severe challenges, especially in dynamically managing its vast multi-dimension resources amid heightened demands for latency, rates, reliability etc. Traditional approaches, particularly those relying on Deep Reinforcement Learning (DRL), have obvious limitations in various and complex 6G IoT networks. In this context, we will explore Generative Artificial Intelligence (GAI) to solve these challenges. First, we will establish a hypergraph-based framework for multi-dimensional resource representation and modeling, targeting the optimization of service capabilities. Subsequently, we will use the Generative Diffusion Model (GDM) to streamline communication intent extraction, facilitating swift decision-making and improving the adaptability of the network. Finally, we will leverage GDM in crafting resilient incentive structures, aiming to ensure the fairness of resource distribution and enhance user experience in the 6G IoT environment. The project has three work packages (WPs): WP1 aims at designing measurements for multi-dimensional resources, WP2 investigates the utilization of GDM for adaptive resource management, and in WP3, we seek to use GDM to ensure fairness in resource sharing. By integrating GAI as a solution to the multifaceted challenges of 6G IoT, we seek to expand and redefine the capabilities and applications of 6G IoT in real-world contexts.

Mots clés : 6g iot, multi dimensional resource management, urllc, hypergraph, generative artificial intelligence

Participants :
- KTH Institut royal de technologie (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 236340.0 €
Projet MIMIC (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Multicellular life depends on the effective communication between cells and their surroundings. One of the primary conduits for cellular interactions is the membrane-embedded receptor family of integrins. Integrins are crucial for several key biological processes, from blood clotting, to proper immune response. Integrin misregulation is at the heart of several diseases, such as Crohn’s disease, MS, or cancer, and integrins are targeted by several viruses as entry points. Yet, our current drugs are not capable of efficiently combating these diseases, as we do not have sufficient molecular and network level knowledge of how integrins work. The main research objective of MIMIC is to develop an original hybrid in silico/in vitro framework that allows the identification and characterization of unknown elements of integrin signaling. It will present the first such systematic large-scale effort, integrating computational modeling with state-of-the-art experimental techniques. MIMIC will provide the first structured description of integrin ligand specificity profiles, extending our current limited descriptions of extracellular integrin interactions. Thus, MIMIC will be the missing link between integrin research and recent advancements in linear motif research. The developed framework will not only enable the identification of currently unknown integrin ligands, but will also lay the foundations for innovative approaches in the development of therapeutic agents for integrin-related diseases. Building on the developed experimentally verified computational models, I will construct a novel peptide-based inhibitor design pipeline. MIMIC will provide a structural basis for currently missing immune-specific interactions in atomic detail. I will use this knowledge to design the first immunomodulatory peptide-based integrin inhibitor, serving as a proof-of-concept for future therapeutic applications.

Mots clés : motif mediated interactions, cyclic peptide, proto drug development

Participants :
- European Molecular Biology Laboratory (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 162806.4 €
Projet WOODSofCHANGE (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Multicellular organisms require an accurate coordination of multiple growth programs to develop. In plants, the lateral growth is the process by which stems and roots grow in diameter. Lateral growth is a pivotal process for plant development that (i) provides the mechanical stability that plants need to expand their growth and sustain their structures and (ii) brings about large amounts of extremely useful plant biomass, especially in the form of wood in trees. Lateral growth is mediated by a specialised group of stem cells collectively called cambium. Remarkably for such a crucial cell-type for plant development and biomass generation, very little is known about the genetic regulation of cambium. Dr. Agusti’s lab has identified new strong potential cambium regulators through a novel approach that combines natural variation and Genome-Wide Association Studies (GWAS) in the model plant Arabidopsis thaliana. Based on the sophisticated skills that I acquired in the field of tree genetics and genomics and on the large experience on genomics techniques held in the lab of Dr. Agusti, I present a project that will: 1) Characterise the role of new potential cambium regulators identified in Dr. Agusti’s lab in Arabidopsis and Aspen trees, using state of the art genetic and molecular techniques. 2) Discover new cambium regulators in Arabidopsis by expanding the natural variation and GWAS approach previously used in Agusti’s lab. 3) Translate the results obtained through 1) and 2) into the generation of new Aspen varieties (using state of the art techniques on tree genetics and genomics that I have extensively used in the past) with the view of enhancing biomass production in Aspen in the form of wood. Results will (i) unravel new and fundamental aspects of the genetic regulation of cambium activity, illuminating our general understanding on plant development and (ii) strongly impact on Europe excellence by enhancing our capacity for plant biomass production.

Mots clés : plant biomass production, wood, cambium activity, arabidopsis, aspen, gwas

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet ORGANIZE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Multicellular tissues, and ultimately complex organisms, are composed of multiple distinct cell types that differ in functional attributes. Such diversity in cell composition (i.e. phenotypic diversity) arises during development and regeneration, where progenitor cells differentiate along multiple cell fate lineages to form a heterogeneous population. While the molecular signals (i.e. cell states) that specify individual cell fates are widely studied, less is known about how multiple cell types can simultaneously emerge from a seemingly homogeneous population and which molecular mechanisms coordinate this process on a tissue-wide scale. Increasing evidence suggests that stochastic events, as opposed to hard-wired deterministic processes, are critical for emergence of heterogeneity. However, the molecular mechanisms that drive stochasticity and diversity in a mammalian tissue remain unknown, mainly due to a scarcity of tools to measure stochastic events in large numbers of single cells and to perturb cell-to-cell heterogeneity on a tissue level. Here I propose to use quantitative single-cell imaging, transcriptomic approaches, and optogenetic control of tissue heterogeneity to identify the molecular mechanisms driving phenotypic diversity. I will apply these techniques to mouse intestinal organoids, a multicellular system that recapitulates the intestinal epithelium. I hypothesize that variability in cell state (at the single-cell level) drives cell phenotypic diversity (at the tissue level). Different combinations of dynamic molecular signals within single cells may thereby pattern populations within a tissue to adopt specific fate outcomes. Gaining insight into the mechanisms of phenotypic diversity will answer fundamental questions in developmental and synthetic biology on the origins of cell diversity in multicellular tissues, how stochastic processes can ensure developmental robustness, and the maintenance of phenotypic equilibrium in homeostasis and disease.

Mots clés : optogenetics, heterogeneity, organoids, tissue organization, dynamics, single cell analysis, transcriptomics, quantitative imaging, stochasticity, modeling, light sheet microscopy

Participants :
- Friedrich Miescher Institute (Suisse) — Coordinator, beneficiary, Recherche, subvention : 191149.44 €
Projet NANOBOTS (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Multifunctional nanodevices have recently emerged as one of the most exciting new classes of drug delivery machineries to perform abiotic prodrug activation in living systems. However, as current designs have not yet been configured with cell targeting capabilities, their use is limited to the targeting of non-metastatic primary cancers. This proposal, termed 'NANOBOTS', aims to develop an unprecedented ‘track and treat’ nanomachine installed with navigational ability to achieve cell-specific targeting and prodrug activation capabilities to treat metastatic cancers. The strategy involves the development of Pd-functionalized and tetrazine-based nanodevices specifically designed to (1) track & tag both metastatic lesions and primary tumours by identification of cell-surface proteins overexpressed in cancer cells, and to (2) activate systemically-administered cytotoxic precursors inside or at the surface of those cells via Pd-catalyzed deprotection or click-to-release chemistry. Using a range of multidisciplinary methods and techniques including Organometallic Chemistry, Medicinal Chemistry, Supramolecular Chemistry and Nanotechnology, I will develop multifunctional nanobots that will enable –for the first time- targeted treatment of metastatic lesions. Importantly, the modular feature of the nanobots provide a solid ground for a powerful breadth of future applications, e.g. exploiting an over-expressed surface protein in a new disease class as 'navigational guide' beyond cancer. With the support of a MSCA-IF, I will have the opportunity of performing a highly-innovative research programme within a chemistry lab based in the Cancer Research UK Edinburgh Centre, a world-class institution on cancer biology and therapy, and under the mentorship of Dr Unciti-Broceta, one of the pioneers of the Bioorthogonal Organometallic Chemistry field. This will certainly promote the translation of the results and enhance my professional growth towards my research independence.

Mots clés : nanotechnology, bioorthogonal catalysis, palladium activated prodrugs, chemotherapy, metastatic cancer

Participants :
- University of Edinburgh (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet InnateMSDyn (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Multiple sclerosis (MS) disease is dependent on an intricate interplay between the adaptive and innate immune systems. Nevertheless, none of the Food and Drug Administration-approved drugs target innate immune cells, because of their unclear roles in the disease process. However, innate immune cells implication in the MS disease is no longer put in doubt. The mobilization, differentiation and spatial-temporal distribution of brain resident and recruited peripheral innate immune cells, in relation with clinical scores, will be analyzed, as an alternative source of disease biomarkers and therapeutic targets. The project combines recent advances in (a) generation of multicolor transgenic reporter mice with subpopulations of cells expressing distinct fluorophores, (b) spectral bi-photon imaging to visualize the cells of interest directly in the spinal cord in living animals, at a subcellular resolution in real time, and (c) multiparametric flow cytometry to characterize over time inflammatory cell types in the spinal cord tissue after disease induction. The activated cells converging to the neuronal lesions, as well as the delay and the effect on the neurons, will be characterized. VEGF will also be tested as potential therapeutic drug, based on the known VEGF effects on neurons and immune cells. This data will provide new insights on MS disease setting up and implicated cells, correlated with clinical scores, neuronal damages and disease progression.

Mots clés : multiple sclerosis, mouse spinal cord, intravital two photon imaging, multiparamatric flow cytometry

Participants :
- Aix-Marseille Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173076.0 €
Projet MS-fMRI-QSM (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Multiple sclerosis (MS) is the most common autoimmune disorder to affect the central nervous system. Demyelination of nerve cells leads to a slowing of electrical signals, causing visual and sensorimotor deficits, cognitive decline and mood changes. Magnetic Resonance Imaging (MRI) plays a central role to in diagnosis through the identification of plaques and active lesions. Recently, functional MRI (fMRI) and Quantitative Susceptibility Mapping (QSM) have been shown to provide insights into the pathogenesis of MS and possible biomarkers of MS subtypes (relapsing-remitting (RR), primary progressive (PP) and secondary progressive (SP)). fMRI shows aberrant neuronal activation in response to motor tasks and changes to the motor resting state networks which are different in RR, PP and SP MS, for instance, whereas QSM provides images of the magnetic susceptibilities of different tissues, revealing iron deposits and demyelination. This action proposes the development of a new MRI sequence which will allow fMRI and QSM data to be acquired simultaneously rather than in two separate scans. This will drastically reduce the scan time, which is vital as many MS patients find it hard to stay still during an MRI. The combined fMRI-QSM sequence used to examine, in different MS subtypes and genders, reorganization of motor function and disruption of functional connectivity (from fMRI) in relation to the distribution of plaques, iron and demyelination (from QSM). The sequence programming in this interdisciplinary project will be carried out under the supervision of Prof. Barth, a physicist who developed the MR method on which the fMRI-QSM scan will be based, at the University of Queensland. In the return phase Prof. Enzinger, one of Europe’s leading MS neurologists, will supervise the clinical study with the combined sequence. This action stands to lead to a step-change in the international standing of the researcher and benefit the host and the European research area.

Mots clés : multiple sclerosis, magnetic resonance imaging, functional mri  fmri, quantitative susceptibility mapping  qsm, ultra high field, neuronal activation, resting state networks, distortion, respiration

Participants :
- Medical University of Graz (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 267458.4 €
- University of Queensland (Australie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MusE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Museums are sites of emotional engagement: what is represented in an exhibition (and how) may influence what visitors will know, think, remember and do – as a consequence of what they felt. This is particularly evident in the current context of global crises, which have brought museums to deal to an unprecedented extent with situations and topics that engender a range of emotional responses, from anxiety to fear, despair, nostalgia, empathy and hope. As new responsibilities and expectations are now placed on museums, curatorial teams are rapidly adapting the content and form of exhibitions: exhibition narratives explicitly invoke vulnerability, resilience and empathy, and offer to help us navigate through the emotional volatility and uncertainty of our times. Yet, whilst we know that exhibitions affect us, virtually no scholarly attention has been paid to emotions in curatorial work. The project then asks: What is the place and role of emotions in curatorial work? How is engagement with emotions impacting on curatorial work and related skills and knowledge? The main aim of this MSCA fellowship is to engage in cross-disciplinary (humanities-affective sciences) and cross-sectoral (academia-museum) collaborative research on emotions in museums. This will be the first study investigating emotions in curatorial practice; it will develop a new concept – emotional competence in curatorial work – and pioneer a novel methodology combining methods in museum studies, psychology and linguistics, with a tight collaboration with museum professionals. I will be based at the Swiss Center for Affective Sciences (CISA), University of Geneva - the world's first research centre dedicated to the interdisciplinary study of emotions and their effects on human behaviour and society. At CISA, I will acquire essential training in the affective sciences (on theoretical and methodological approaches to the study of emotions) and apply this new knowledge and skills to the project.

Mots clés : exhibitions, emotions, curatorial practice, emotional competence, curatorial expertise, affect, museum professionals, affective sciences

Participants :
- University of Geneva (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203149.44 €
Projet ReduceFear (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

My ambition is to become an independent PI and clinical psychologist with a novel research line focusing on treatment optimization and personalization for anxiety disorders and post-traumatic stress disorder (PTSD). The MSCA-IF will provide the essential building blocks for this research line, and provides the opportunity to develop generic skills necessary to transfer from a postdoc position to an Assistant Professor position. Training through research: I will bring my expertise in neuroimaging and clinical psychology to the host, and the host’ PI will train me in experimental task development. The aim of ReduceFear is to examine fear reduction strategies that play a role in exposure therapy, the gold standard therapy for anxiety disorders and PTSD. These disorders are highly common, and up to 50% of patients do not benefit from the therapy. The project will concurrently assess (a) extinction learning, a process that reduces the over-expectation of harm but is highly fragile and dysfunctional in anxiety patients, and (b) threat (US) devaluation, a highly-understudied process that has potential to more robustly reduce excessive fears by reducing the perceived aversiveness of the threat. Overall objective: to examine for the first time (1) the neurobiological mechanisms of US devaluation compared to extinction learning to identify (pre)clinical targets for therapy augmentation, and (2) US devaluation mechanisms in patients with anxiety disorders. If anxiety patients not show any deficits in US devaluation, exposure-based therapies may be adapted to enhance focus on US devaluation. Hands-on training: As identified by a Gap Analysis, I will work on the following competences in order to reach scientific maturity and to successfully lead my own research group in the future: (1) Networking, (2) Time-management / Self-management, (3) Grant Writing, (4) Leadership, (5) Teaching, and (6) Communication/Dissemination.

Mots clés : functional mri, psychological therapy, experimental psychology, anxiety, ptsd

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 178320.0 €
Projet Matthew (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

My fellowship project, ‘Expanding the Gospel according to Matthew: Continuity and Change in Early Gospel Literature’, takes an integrative approach to early Christian literature that intervenes in ongoing debates about textual continuity and change. Recent scholarship has challenged conventional conceptions of Gospels as stable texts, pointing to porous constellations of Gospel material in the first centuries of the Common Era. This renewed critical attention disrupts reductive analytical frames and invites fresh questions. Nonetheless, emphasis on fluidity risks concomitant fragmentation, obscuring connections between diverse instances of Gospel tradition. Both continuity and change characterized early Gospel literature. My project addresses this tension through a rigorous reception-historical study of the Gospel according to Matthew. Matthew is a fruitful locus of investigation because of its centrality to Gospel scholarship and because it is richly attested in early expansions. Matthew takes many textual forms. This diversity stands in tension with the bibliographic continuity that underlies common-sense notions of ‘Matthew’ as a recognizable body of material. But, I argue, these diverse forms express the possibilities, the DNA, of Matthew as a work over time. By attending both to the diverse ways in which Matthew expanded and to underlying patterns uniting these various instances, the project advances scholarship on Matthew. The method and results of this project will enrich broader conversations about the production and reception of early Christian literature. My project will result in a completed book manuscript, two articles submitted to top-tier journals, and other scholarly communications. The project will contribute to Oxford’s vibrant interdisciplinary research environment and advance my development as an early career researcher, laying a foundation for future scholarly excellence.

Mots clés : early christianity, new testament, gospel literature, reception history, gospel according to matthew, jewish christianity, papyri, textual criticism, digital humanities

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €