Projet HaloVerse (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks - Joint Doctorates
Panel : Chemistry
Statut du projet : SIGNED

The mission of the HALOVERSE double doctorates PhD programme is to train 13 PhD students in a synergistic multidisciplinary environment to lead Europe's next generations towards sustainability in halogenation, a highly polluting chemical process. Enzyme catalysis contributes to sustainability through efficient use of natural resources and energy, minimising environmental impact and supporting the European Green Deal, the MSCA Green Charter and the UN SDGs. HALOVERSE will develop powerful enzymatic systems for selective halogenation to revolutionise 21st century chemistry. It aims to overcome the limitations of enzymatic halogenation by discovering and engineering biocatalysts with broad catalytic scope, substrate diversity and robustness, and by developing new process strategies for the functionalisation of complex molecules. HALOVERSE will bridge academic proof-of-concept knowledge with industrial applications by integrating the predictive power of computational biology and novel continuous process strategies on three classes of halogenases to produce versatile pharmaceuticals, fine- and agrochemicals. The scientific approach of the double degree programme will provide in-depth training in complementary disciplines, combining advanced enzymology and computational biology with the engineering challenges posed by halogenases in industrial settings. Industrial partners will lead innovation, scale up commercially relevant processes focusing on continuous synthesis and contribute to the training programme, ensuring technology transfer and development strategies, both career and product oriented. HALOVERSE will ensure European leadership in industrial biotechnology, paving the way for bio-based materials and products with a low environmental footprint, preventing and mitigating pollution. 12 non-academic partners and 10 academic institutions provide a synergistic environment and offer 13 PhD students excellent employability profiles in the European biotechnology sector.

Mots clés : biocatalysis, biotechnology, halogenases, protein engineering, enzyme promiscuity

Participants :
- BASF (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de la Ruhr à Bochum (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 774059.52 €
- Université de Crète (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 359312.64 €
- Inseit ag (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Stuttgart (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 387029.76 €
- Université de Pavie (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 375673.44 €
- Université de Milan (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 375673.44 €
- Syngenta (United Kingdom) (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- AstraZeneca (Sweden) (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Groningue (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1221143.04 €
- Bayer (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Zymvol biomodeling sl (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de technologie de Delft (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Brain (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Berne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Enzyan biocatalysis gmbh (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Exazyme gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Aminoverse b.v. (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Nova Institut (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Gérone (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 376250.88 €
- Prozomix (United Kingdom) (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €