Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet PECSolFuel (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

PECSolFuel aims to develop an environmentally benign bias-free photoelectrochemical device for energy-efficient NH3 production to replace the energy-intensive and fossil-fuel-driven Haber-Bosch process. To achieve this, PECSolFuel has been tailored to overcome the current limitations of the solar-driven NH3 production alternative schemes involving: 1) the lack of selective and stable catalyst for efficient N2 reduction; 2) the dependence of sluggish and energy demanding reactions; 3) the requirement of a high photovoltage and 4) the catalyst degradation during long-term operation. By choosing appropriate redox reactions (such as glycerol oxidation coupled with nitrate reduction) and the rational catalysts design (involving the stabilization of small metal nanoparticles on the step-edges of photocatalytic inorganic supports), as well as the efficient integration of photoelectrodes using perovskite-based photocathodes, the photoelectrochemical device produced in PECSolFuel will not require external energy input. The synthesis of value-added products via glycerol oxidation reaction coupled with nitrate reduction reaction will be studied for the first time within this project. PECSolFuel will deliver: i) New catalysts that are not only highly-selective and active, but also highly-durable for both the nitrate reduction and the electrocatalytic oxidation of glycerol; ii) High-performance integrated perovskite photocathodes; iii) A two compartments photoelectrochemical device enabling a 20 % of solar-to-NH3 conversion efficiency by in situ valorisation of glycerol. Joining Dr. Gimenez group will allow me to establish myself as independent researcher and leading expert in solar fuel production in a group with key expertise, resources and links with academia and industry for the success of this action. PECSolFuel will provide me with hands-on experience and training in scientific competences and strengthen my transferable skills, while expanding my professional network.

Mots clés : photoelectrochemical system, electrocatalysis, metal nanoparticles, perovskite based photocathode, solar fuel production

Participants :
- Université de Saint-Jacques-de-Compostelle (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet BOOST (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Developing effective membrane transporters is a key challenge for the delivery of nucleic acid-based drugs. Despite the exponential discovery of such biomolecules with therapeutic potential, the majority of them may need to be discarded from further development for being too hydrophilic to cross the lipid membrane. Future delivery technologies require the development of conceptually new approaches that can overcome the emerging limitations of current carriers and strategies. Recently, superchaotropic boron clusters have been validated to activate the transport of a broad range of hydrophilic cargos. The “anionic nature” of these clusters offers an alternative transport scenario. The clusters will not aggregate with hydrophilic anionic domains and, instead, will be repelled by anions. Therefore, they could be exploited to modify the structure of cargos without altering their solubility and function. The main goal of this action is the connection of superchaotropic boron clusters to hydrophilic biomolecules such as probes and nucleic acids to enable their autonomous membrane transport, while preventing self-aggregation and unspecific interactions with other biological surfaces. This will be achieved through an interdisciplinary approach that will simultaneously provide me with valuable training in chemistry, biology and biophysics, promoting my scientific independence. Short oligonucleotides will be designed to incorporate a variable number of modified nucleosides for future functionalization with boron clusters. Modified oligonucleotides, such as those bearing alkyne or azide functions, will be purchased from commercial sources and combined with cluster derivatives using click chemistry. These new chaotropic oligonucleotide hybrids will allow understanding and validating the application of self-delivering fully anionic nucleic acids with therapeutic potential.

Mots clés : supramolecular chemistry superchaotropic carriers boron clusters membrane transport nucleic acid chemistry

Participants :
- Université de Saint-Jacques-de-Compostelle (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €
Projet PvRecur (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Malaria infects hundreds of millions of people year on year. The WHO is committed to a world ultimately free of malaria. Of the two most important causes of malaria, Plasmodium vivax is the most difficult to eliminate largely because it has the capacity to relapse: causing recurrent malaria via the activation of latent liver-stage parasites. Recurrent malaria can also be caused by the failure to treat a previous blood-stage infection (recrudescence) and, in endemic settings, new infectious mosquito bites (reinfection). Knowing the cause of recurrent malaria is key to understanding malaria epidemiology and to providing efficacious treatment. For example, to evaluate the efficacy of a drug designed to kill P. vivax liver-stage parasites in an endemic setting, reinfections and recrudescence must be separated from relapses. However, there are no direct ways to diagnose the cause of recurrent malaria. To address this problem, I aim to build a tool (Pv3R) that uses Plasmodium vivax genetic data to estimate the probability of Relapse, Recrudescence and Reinfection, and use Pv3R to estimate the burden of relapse and its contribution to transmission, thereby validating Pv3R’s utility. I will achieve my objectives by merging my existing expertise in statistical malaria genetics with the expertise of Dr Michael White and his lab, its ties with field-based P. vivax epidemiology and its capacity to generate P. vivax genetic data. Working with Dr White, I will develop a state-of-the-art statistical inference method to tackle the challenging unsolved problem of differentiating between the causes of recurrent P. vivax. This will generate knowledge that directly improves our understanding of P. vivax epidemiology and, most long-lastingly, a public health resource (Pv3R) that can be used sustainably by the malaria community to generate more epidemiological knowledge and to guide the design of more effective treatment regimens needed for P. vivax control and elimination.

Mots clés : malaria, plasmodium vivax, statistical genetics, bayesian modelling, markov chain monte carlo mcmc

Participants :
- Institut Pasteur (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet AntScat (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : TERMINATED

The surprising findings of collective effects in nucleon-nucleus and nucleon-nucleon collisions (and very recently even in electron-positron collisions), previously thought to be exclusive to large systems such as nucleus-nucleus collisions, pose an important challenge to the particle physics community. Both from the heavy-ion and the high-energy communities, intense efforts are devoted to gain a better understanding of the origin of collectivity in QCD. This project revolves around the theoretical study of the interactions among coherent objects and their phenomenological implications. So far, these type of interactions have been absent in the respective state-of-the-art descriptions of the dynamical evolution of QCD at colliders adopted by both communities. The first goal of this project will be to compute the cross-sections for a new set of processes, ranging from the interaction of on-shell particles with colored dipoles to the interactions among dipoles with other dipoles. As a result of these interactions, broadening and stimulated radiation can take place. The features of the dipoles, such as their mass, are imprinted in the scattered object due to the phenomenon of color and quantum interference. These physics translate in the appearance of non-trivial correlations among these objects. A second aspect of the project will consist in the phenomenological modeling that these correlations can have in a) QCD parton showers, the natural scenario from the high-energy front, where interactions among parton and multi-parton objects will be added to the typical splitting processes and b) QCD effective kinetic theory, the natural scenario from the heavy-ion front, where the inclusion of the coherent objects can be modeled by considering them as unstable particles. A detailed study of the observable effects that these new correlations can induce will shed light on the role played by the physics of quantum interference in describing the origin of collectivity in QCD.

Mots clés : qcd, quantum interference, collectivity, color dipoles, parton showers, effective kinetic theory

Participants :
- Université de Saint-Jacques-de-Compostelle (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet PATHOGEN (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Tuberculosis (TB), the infectious disease produced by the Mycobacterium tuberculosis complex (MTBC), remains one of the highest global disease burdens. However, the current body of knowledge on the MTBC is biased towards certain lineages, particularly lineage 4 that spread from Europe to the Americas during colonial expansion. Recent advances in ancient DNA research have the potential to broaden this picture with the recovery and analysis of whole genomes from strains that infected human populations in the past. Indeed, these approaches have been recently used to identify ancient MTBC animal associated strains infecting humans in South American before the arrival of Europeans. Analysis of these strains estimated that the MTBC most likely emerged during the Neolithic approximately 6000 years ago (much later than previously thought). The PATHOGEN project, will seek to use these approaches to shed new light on the emergence, diversity and spread of MTBC strains in the Southern Cone of the Americas, a neglected region concerning the epidemiological history of TB. By employing ancient DNA methods to examine and screen putatively positive TB infections of humans from archaeological and historic contexts of the current territory of Argentina, I will potentially provide genomic representation of TB histories over a broad time transect from precolonial populations to post-colonial cemeteries. With these data, I will perform phylogenomic and molecular clock analyses to investigate i) changes in strain diversity over time in the region, ii) the historical and socio-economical contexts that favoured the emergence and spread of the detected strains, iii) the emergence of genetic changes with potential clinical relevance identified in MTBC strains over the past centuries. By offering a view of the past, the PATHOGEN project will increase our understanding of the diversity of MTBC across time and contribute a new perspective of the evolutionary and epidemiological histories of TB.

Mots clés : ancient dna, tuberculosis, south america, phylogenomics, pathogen genomics, pathogen evolution, emergence of infectious diseases, history of infectious diseases, mycobacterium tuberculosis complex

Participants :
- Institut Pasteur (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet COMPEL (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The ability to attend to literary data in a variety of languages is crucial towards an understanding of literary practices across time and traditions. Yet few are the languages endowed with adequate computational resources for literary analysis. Increasing the resources enabling computational literary analysis in lesser-studied traditions is the goal of COMputational Analysis of PEripheral Literatures (COMPEL), focusing on Galician literature, a rich but peripheral tradition at the crossroads of two major romance literatures, Portuguese and Spanish. This will be an opportunity to study which features become canonical in a peripheral tradition compared to major traditions influencing it, with descriptive and predictive models. The project promotes a more inclusive and precise literary history via approaching a tradition little studied using computational means. By concentrating on Galician, a language covered by the European Charter for Regional or Minority Languages, the project contributes to European linguistic diversity goals. Beyond Galician, results are expected to be applicable to comparing core and peripheral literatures in other language contact settings, e.g. the influence of French and Spanish literature in Catalan or French and German literature in Alsatian. The project will focus on two genres, poetry and narrative, and two main Galician literature movements in the 19th century and at the turn of the 20th century; public domain texts will allow us to release project resources under open licenses. We will develop several methods to compare texts across literary traditions: Among others, a supervised learning method (perspectival modeling) based on versification features and content features, carrying out a cross-lingual comparison unattempted in earlier studies. By comparing a regional tradition with two major European ones, COMPEL helps promote a sense of European identity via smarter cultural heritage acess, a current EU priority.

Mots clés : computational literary studies, versification, large language models, interpretability, peripheral literatures, neurosymbolic methods

Participants :
- Editorial galaxia, sa (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Centro universitário ritter dos reis (uniritter) (Brésil) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Saint-Jacques-de-Compostelle (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet TriSH (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Phages, viruses that infect bacteria, play key roles in shaping bacterial fitness and evolution. At the same time, phages themselves are parasitized by satellites - mobile genetic elements (MGEs) lacking genes for autonomous replication but that can hijack (helper) phages for their own propagation. Despite billions of years of coevolution between satellites, phages and bacteria, we know little about how selection affects these elements and their interactions. Recent studies showed that P4-like satellites are diverse and widespread across distant bacterial genomes, but outside a few P2-like prophages described decades ago, the actual range of phages that P4-like elements can hijack is unknown. The aim of my project is to decipher the mobilization potential of P4-like satellites, study the genetic basis of this mobilization and reveal how selection acts on satellites, phages and bacteria when they coevolve. With access to over 200 strains of Escherichia coli and Klebsiella, I will combine experimental and computational analyses to shed light on the genetic and evolutionary interactions between P4-like satellites, their helpers and their common bacterial hosts. Leveraging my expertise in microbial evolution and molecular biology, this project will introduce new expertise in satellite biology, bioinformatics, and coevolutionary microbiology. This project will provide new models to explore satellite-helper dynamics, with potential applications in biotechnology and phage therapy. At the Institut Pasteur, I will collaborate in an interdisciplinary environment within the Department of Genomes and Genetics, receiving outstanding academic training with numerous opportunities for interdisciplinary collaborations. This provides unique prospects for my career development towards independency. Research findings will be published in high-impact journals, open-access, and presented at international conferences, with outreach efforts to engage a broad audience.

Mots clés : phage satellites, bacteriophages, coevolution, escherichia, klebsiella, microbial interactions, experimental evolution

Participants :
- Institut Pasteur (France) — Coordinator, beneficiary, Recherche, subvention : 226420.56 €
Projet MULTISURREALISM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

By studying a set of surrealist cultural journals edited during the 1930s and 1940s, MULTISURREALISM will examine the intercultural exchange between surrealist Latin American and European artists and writers, to analyze the way their ideas, agreements, tensions, and debates had an impact on the revalorization of the Latin American artistic and symbolic production, as well as on the understanding of European civilization. With an interdisciplinary approach (Literature Studies, Visual Arts Studies, Graphic Design, Discourse Studies, History of Ideas), the research will focus on the literary and artistic production of the surrealist multicultural network, as it has been manifested in magazines such as Minotaure (Paris, 1933-1939); VVV (New York, 1942-1944); Dyn (Coyoacán, 1942-1944); El Uso de la Palabra (Lima, 1939); Las Moradas (Lima, 1947-1949); Mandrágora (Santiago, 1938-1942) and Leitmotiv (Santiago, 1942). The overall hypothesis states that the surrealist multicultural relation promoted a different glance over Latin American culture since the assumption that Latin America is a land where surrealism arises naturally belongs to an ethnocentric perspective constructed by both European and Latin American surrealists. Still, it simultaneously allowed them to question the assumed subordination of Latin American culture, giving a new shape to its identity and influencing its Literature until the rise of the Latin American Boom. The project aims to connect different archive materials to analyze what this movement wanted to express, and also its unintentional effects and underlying meanings, to study its impact as a multicultural group. The final goal is to broaden the perspective about surrealism's role in the Latin-American culture of the XX Century, which promoted transatlantic bonds that have enriched both cultures and opened them to the world. This plan will be developed at Universitat Pompeu Fabra under the supervision of Dr. Domingo Ródenas de Moya.

Mots clés : surrealism literature art multiculturalism cultural identity intercultural exchange internationalism cultural magazines study archive ethnocentrism transatlantic studies

Participants :
- Université Sorbonne Nouvelle (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Pompeu Fabra (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet EXEMPT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Exclusionary environments of the emerging energy and political transitions (EXEMPT) looks at the underpinning exclusions evident in different ideological varieties of environmentalism and environmental policies. Through an interdisciplinary theoretical and methodological approach, building on insights from environmental sociology, politics, psychology, anthropology and economics, EXEMPT will examine the understudied contexts of Serbia and Montenegro, as epistemic semi-peripheries in which a wide array of environmental concerns has only recently become recognized at a larger scale. The fundamental aim of EXEMPT is thus to examine the environmental imaginaries and their related ideological underpinnings in light of the explicit and implicit exclusions in the emerging contexts of environmental activism and policy. To reach this aim, EXEMPT builds on three fundamental building blocks - objectives: the first is to conceptualize "exclusionary environmentalisms" by explaining how different imaginaries and ideologies underpin exclusion, developing an "environmental imaginaries scale" in the process, a tool that could be used in future quantitative or mixed-methods inquiries. The second objective is to explore, through the use of digital ethnography and qualitative interviews, how "microfascism" - silent exclusion and tacit elimination of the "unwanted" elements in an imaginary, occurs in the everyday environmental activism and policy. Much as exclusion is a constitutive part of identity building, hence of politics, the third and final objective of EXEMPT is also to explore and test the communicative ways in which exclusion can be mitigated in an attempt to 'open' environmentalism to different imaginaries, experiences and geographies. As such, this project points to both theoretical and practical ways of identifying, examining and addressing activist and policy exclusion.

Mots clés : environment exclusion policy energy serbia montenegro microfascism silence imaginary ideology mixed methods qualitative interviews digital ethnography quantitative methods semi periphery

Participants :
- Université Pompeu Fabra (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €