Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet EcoPlanAge (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

EcoPlanAge revisits planning as one of the crucial political concepts of the 20th century and offers a new conceptual framework for democratic ecological planning in the 21st century. With climate change, the pandemic and the war in Ukraine, expressions like ‘war economy’, ‘plan’ and ‘new deal’ have ceased to be relics of the past. Degrowth (DG), Green New Deal (GND) and Green Growth (GG) rationalities are either praising or criticizing planning as an effective tool to tackle our polycrisis. Yet, some celebrate its democratic nature, others perceive it as authoritarian. EcoPlanAge identifies an urgent need for conceptual clarification: what precisely does planning mean in the contemporary era? On what grounds is it praised or criticized? By crossing political theory, conceptual history and political ecology it shows how DG, GND, GG rationalities are still influenced by the two strains that have characterized the 1920s socialist calculation debate on planning possibilities: the formal rationality of neoliberalism and the substantive rationality of socialism. EcoPlanAge selects four authors who affect eco-planning debates: Ludwig von Mises and Friedrich August von Hayek (neoliberal strain); Otto Neurath and Karl Polanyi (socialist one). It reconstructs their epistemological and political theories and analyzes the conception of nature, time and gender that underpin their planning frameworks by highlighting the interrelation between their political theories and the concrete historical planning experiments of their time (war economies, Red Vienna, New Deal, Fascism, Nazism, Soviet planning). Finally, it discusses the utility of these planning theories in thinking about a new conceptual framework for democratic eco-planning in our age of polycrisis. The project will be carried out at the University of Bologna (Prof. Michele Filippini, Prof. Emanuele Leonardi), at Boston University (Prof. Quinn Slobodian) and at Brunel University London (Prof. Gareth Dale).

Mots clés : history of political thought, conceptual history, neoliberalism, planning theories, political ecology, environmental political theory, mises, hayek, neurath, polanyi, degrowth, green new deal

Participants :
- Boston University (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 300169.44 €
- Université de Bologne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 396991.08 €
- Brunel University London (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MOBILE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Microbes have remarkable capabilities to attach to surfaces of natural and artificial systems, eventually leading to the formation of biofilms and associated chronic and persistent infections. It is extremely appealing to understand how bacteria interact with three- dimensional surface topographies and how to design smart patterns as a strategy to create antifouling and biocidal materials. Here I propose a dynamic strategy, merging verstile and large-scale surface modification teqhniques based on mechanical wrinkling of soft bilayers, that I developed at Imperial College London, microfluidics and microbiology. The goal of MOBILE is investigating the mechanical confinement exerted by non-planar surface curvatures and spatial heterogeneities induced by fluid shear on bacterial initial attachment and removal, in confined environments. Specifically (Aim 1), I will evaluate the combined action of surface topography and fluid shear over bacterial proliferation, motitly and viability, incorporating nano- to micro-scaled wrinkled geometries in microfluidic channels, mimicking biological tissues surfaces and implantable medical devices, testing a series of different clinically relevant bacterial strains (such as Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae). I will also (Aim 2) develop antifouling and removal strategies by investigating the mechanical response of adhered bacteria, using patterned surfaces as stimuli-responsive probes "actuated" by means of mechanical deformation (i.e., by extension and compression of the wrinkled topographies) to induce detachment and surface cleaning under fluid dynamic conditions. Overall, I aim to elucidate new methodologies for bacterial removal at different stages of biofilm formation paving the way towards the development of new classes of biomedical devices and to contribute to an important step in direction of controlling implant-associated infections.

Mots clés : bacterial colonization, biofilm, patterning, wrinkling instabilities, soft matter, microfluidics, controlled flows, mechanosensing, cleaning, implants

Participants :
- École normale supérieure de Lyon (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Humanitas University (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet INCLUDE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

This project addresses a critical and timely gap in urban sustainability by focusing on inclusivity in Urban Community Gardens (UCGs), which are increasingly vital communal spaces for social cohesion, mental and physical health, and sustainability. Despite their growing role, the inclusivity of UCGs remains under-examined, with many failing to reflect the diversity of their communities. The urgency of this research is underscored by global efforts to meet the United Nations' 2030 Sustainable Development Goals (SDGs), particularly SDG 11, which calls for inclusive, safe, and resilient cities. Using a mixed-methods approach that integrates qualitative and quantitative data, alongside a co-creation framework with community stakeholders, this project will develop an innovative Inclusivity Conceptual Framework, Inclusivity Evaluation Index (IEI) and an Inclusive UCG Toolkit. These tools will offer practical, evidence-based solutions for local authorities, urban planners, and policymakers to create more inclusive green spaces, address inequalities in community garden access, and align with global sustainability goals, positioning UCGs as key drivers of inclusive, equitable urban development. The project’s real-world impact will be demonstrated through an Oxford Impact Case Study, where the findings will directly inform urban planning practices and policies. The project will enhance my career development through advanced training in interdisciplinary research and international collaboration, equipping me to lead future projects and secure multinational grants as an independent academic.

Mots clés : urban community gardens, inclusivity, urban planning, inclusivity evaluation index

Participants :
- Université de la Colombie-Britannique (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Oxford Brookes University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 375035.4 €
Projet PHOTO-STEREO (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The PHOTO-STEREO action provides a general synthetic platform for the organocatalytic enantioselective dearomatization of heteroaromatic compounds by means of [2+2] photocycloadditions to obtain complex saturated polycyclic compounds in one step under mild conditions. The proposed strategy relies on the direct excitation, by means of visible light, of organocatalytic heteroaromatic intermediates to access their excited state reactivity. Furthermore, the implementation of this methodology into a flow system will enable the collaboration of the host institution with an industrial partner, offering to the fellow a valuable experience of the dynamics in industrial R&D. PHOTO-STEREO will merge the expertise of the group of Prof. Dell’Amico in photoredox catalysis with the expertise of the fellow in asymmetric organocatalysis. Overall, this project promotes the efficient use of sustainable resources, such as light and inexpensive heterocyclic feedstocks, while bringing innovation into the fields of synthetic organic chemistry and medicinal chemistry. This project will ultimately contribute to the EU’s scientific excellence, and at long term, to scientific innovation with a positive impact in the society and EU’s economy. Importantly, all the competences acquired during the realization of this fellowship, together with the creation of new connections with industry and academy, will allow the fellow to reach a position of complete professional maturity, while providing her with fruitful opportunities for gaining a permanent position as senior scientist in both academic, or industrial settings

Mots clés : asymmetric synthesis, organocatalysis

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- F.i.s. fabbrica italiana sintetici spa (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet DyMERE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

This proposal aims to decipher the dynamic regulatory landscapes of chromatin modifiers during embryogenesis. In particular, I envision to unravel their mechanism of action at unprecedented resolution using single-cell based techniques, and provide novel insights on the molecular deregulation that leads to diseases such as cancer. The originality of this approach is to simultaneously address the function of hundreds of chromatin modifiers in early development by using a higher throughput, stem cells-based in vitro screen. In order to achieve this, we will take advantage of a recently established culture system that faithfully recapitulates embryonic development up to somitogenesis in the dish. The combination of various cutting-edge techniques with this model (Cas9-based screening, targeted protein degradation, low input CUT&RUN and single cell RNA-seq) and our sophisticated computational strategies will allow a precise understanding of how various chromatin regulators act on specific targets in individual cell. In particular, we will resolve gaps of how two essential, global modifiers, Polycomb repressive complex 1 and 2, cooperate to regulate distinct cell identity decisions. Ultimately, we will hope to reconstruct the hierarchal dynamics of chromatin regulators at a temporal and spatial resolution of single cells through embryogenesis. The result of this action will be shared with scientific community by open-access peer-reviewed journals, conferences, analytic codes and sequencing data; and with general public through Open Science Days. The Meissner laboratory will provide the ideal environment not only to carry out this project, but also expand my scientific expertise and train my skills to better prepare me to become an independent group leader in the future.

Mots clés : synthetic embryos, epigenomics, molecular genetics

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet PhaeoCREEvol (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : TERMINATED

Brown algae are a multicellular clade that display remarkable diversity in developmental and physiological complexity, and in life history traits. They evolved independently and more recently than animals and plants, making them a uniquely powerful system to characterise the genomic changes that underlie the emergence of complex multicellularity. I will specifically test the hypothesis that cis-regulatory element (CRE) evolution plays a leading role the evolution of complexity. Harnessing large-scale multiomics datasets, I will quantify lineage-specific rates of CRE gains and losses, and attempt to link these events to transitions in complexity. I will combine signatures of constraint from a 59-species whole-genome alignment with functional epigenomic data (ATAC-seq, ChIP-seq) from five representative species to produce fine-scale maps of deeply conserved and recently acquired CREs. To understand the mechanisms of CRE evolution, I will annotate transposable elements (TEs) and quantify variation in TE diversity, abundance and activity. I will characterise what roles TEs have had in CRE dissemination. I will also explore between-species variation in the proportion of proximal and distal CREs. I will analyse high-resolution Hi-C data for four species to ask what effect distal regulation has on 3D genome organisation (i.e. are distal CREs and the genes they regulate topologically associated?). PhaeoCREEvol will inform upon the rates and mechanisms of CRE evolution during the emergence of complexity, providing a highly pertinent comparison to animals and plants. This will increase our knowledge of regulatory evolution in general, while shedding light onto the fundamental biology of a largely unstudied eukaryotic group. Brown algae play critical ecological roles and have significant potential to mitigate climate change, enhance global food security, and deliver novel industrial solutions, providing key motivations to better understand their genetics and evolution.

Mots clés : brown algal evolution, multicellularity and complexity, cis regulatory elements, transposable elements, 3d genome organisation

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet ThorGW (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Gravitational waves (GWs) provide a unique opportunity to test gravity in a regime inaccessible to traditional astronomical observations. One of the main predictions of general relativity (GR) is the existence of black holes (BHs) featuring a horizon beyond which nothing — not even light — can escape. Observations of GWs from the remnants of binary BH coalescences have the potential to probe the physics at the horizon of BHs. This prospect is of particular interest given some quantum-gravity theories and dark matter models that predict the presence of horizonless compact objects, known as exotic compact objects (ECOs). ECOs emit a different GW signal than BHs due to the absence of a horizon. Studying their imprints in the postmerger stage allows one to investigate the existence of horizons in compact remnants. So far, the ground-based detectors LIGO and Virgo have detected GWs from the coalescence of binary BHs and neutron stars. Several tests on the properties of the remnants have been performed, setting constraints on generic deviations from general relativity. Current constraints can be converted into bounds on the location of the horizon by modelling the variations introduced by a generic class of ECOs. However, this aim has not been achieved given the open problems in modelling spinning ECOs, which I plan to tackle in this proposal. This project will provide the first bounds on the location of the horizon with current GW observations. For this purpose, I will extend the current state-of-the-art in ECO modelling to spinning configurations and develop new data-analysis schemes relating the postmerger GW signal to the horizon properties. Finally, I will assess the prospects of detectability of BH horizons with next-generation detectors, such as the ground-based Einstein Telescope and Cosmic Explorer and the space-based Laser Interferometer Space Antenna. The outcome of this project will provide novel tests of general relativity and shed light on quantum gravity.

Mots clés : strong gravity gravitational waves black holes exotic compact objects

Participants :
- Université de Copenhague (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet WildEuro (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Standardized, large-scale monitoring programs are critical to track progress toward the biodiversity and sustainable goals identified by several international initiatives, including the European Green Deal. Yet, these programs are hard to establish, often because of limited resources. International collaborations centered on data and knowledge sharing can fill this gap. The future fellow will gather and collate camera trap data collected across Europe in the past decade to quantify the impact on wildlife of the presence of humans and their domestic species in natural environments, at a fine temporal scale, and for the first time, across Europe. The mere presence of human and free-ranging dogs, cats, and livestock in natural environments might be detrimental to wildlife populations, with relatively unknown consequences on species’ persistence. This action aims at 1. quantifying the effects of human presence on mammals’ occupancy and activity; 2. assessing distribution and co-occurrence of free-ranging domestic animals and wildlife populations; 3. quantifying the effects of free-ranging domestic cats on urban and suburban mammal and bird communities. Along with leveraging publicly shared datasets, this action will build on and cement emerging European camera trap collaborations, and, thus, help establish the long-term, large-scale monitoring program that is paramount to tracking the status of terrestrial communities across Europe and informing European conservation policies. The future fellow will be hosted at the Max Planck Institute of Animal Behavior, a leading actor in the study of animal behavior and a strong promotor of European large-scale camera trap efforts. The future supervisor, Prof. Martin Wikelski, is a pioneer in leveraging international collaborations and technology to advance our understanding of animal decision-making processes across large scales. This action will greatly advance the fellow's expertise and establish her as an independent researcher.

Mots clés : camera trapping human wildlife interactions eco tourism disease spillover urban ecology collaborative networks free ranging domestic species

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet MIDEARI (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Bacterial infections in the human body mostly involve biofilms - locally dense populations of bacteria that are extremely difficult to treat with antibiotics. Understanding antibiotic-biofilm interactions is crucial if we are to design better antibiotic treatment regimes to avoid the emergence of antibiotic resistance. In biofilms, bacteria are surrounded by a biopolymer matrix which can inhibit the motion of antibiotic molecules, leading to complex diffusive behaviour. Yet it is not known how these biophysical matrix-antibiotic interactions influence bacterial killing in a spatially complex infection model. Answering this question is the objective of my proposal. I will set up a lab model that mimics Acute Otitis Media -bacterial infection of the middle ear- and I will use advanced microscopy methods to track antibiotic molecules as they interact with bacterial biofilms. I will answer the following questions: A) what is the spatio-temporal distribution of antibiotic molecules in the biofilm? and B) What is the effect of biofilm structure on the antibiotic response, at the single-cell level? After establishing materials and protocols (objective 1), I will use fluorescence-correlation-spectroscopy (FCS) to characterize the spatial distribution of antibiotic molecules (objective 2). Next, I will use state-of-art 2D STED-FCS method (combination of FCS with stimulated-emission depletion microscopy) to track in unprecedented detail how antibiotics kill individual bacteria within a biofilm (objective 3). Finally, by tracking bacterial growth over long times, I will determine how antibiotic resistance emerges in these spatially complex biofilms (objective 4).

Mots clés : bacterial middle ear infection mimicking antibiotical therapy in middle ear

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 161291.72 €
Projet PositiveWorld (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

Our understanding of the fundamental laws of Nature is based on the study of scattering amplitudes, traditionally computed using Feynman diagrams. In the past three decades, the shortcomings of this representation have become increasingly clear. Scattering amplitudes enjoy a simplicity which is destroyed by Feynman diagrams, resulting in an overwhelming apparent complexity of computations. This has motivated the search for alternatives to Feynman diagrams, which culminated in the discovery that scattering amplitudes in two toy theories, maximally supersymmetric Yang-Mills theory, and the simplest theory describing colored scalars, can be computed as "Volumes" of positive geometries: regions in kinematic space carved out by inequalities. In the new representation it is the usual properties kept manifest by Feynman diagrams, Locality and Unitarity, which are now obscured while the simplicity of scattering amplitudes is restored. These developments are both conceptually intriguing and practically useful; however, they have so far been limited to applications in toy theories only. The goal of PositiveWorld (Positive geometries in the real World) is to address this issue, using the lessons learned in these examples to describe our world, thus marching towards a reformulation of physics completely alternative to the traditional language of Quantum Field Theory and Feynman diagrams. The guiding principle in this exploration is that progress is measured by the efficiency of computations. Therefore, concrete results within PositiveWorld are presented in the form of novel algorithms to address calculations on various topics of scattering theory, with practical applications for theoretical predictions of experiments taking place at particle colliders.

Mots clés : scattering amplitudes, string theory, perturbative qcd, collider physics, algebraic geometry, combinatorics

Participants :
- Institute for advanced study - louis bamberger and mrs felix fuld foundation corporation (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 265647.84 €