Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Cork Discovers (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

Cork Discovers aims to create a fun, interactive and thought-provoking world of research for European Researchers’ Night (ERN) 2020. The theme of the 2020 event is change. An event that promises to be fun for all the family, people will be invited to ‘discover their changing world’ (figure 2) and explore the positive changes research has made and continues to make to our daily life. Our proposed event is an evolution of the Cork Discovers project which ran its first ERN in 2018 and whose public awareness campaign has reached almost 200,000 people. Our ambitious aim is to build on our existing brand to present a significantly bigger and better ERN this year. It will: • Expand to a two-day event with an exciting programme planned for Saturday for the first time • Further geographic reach by spreading beyond Cork City and county to 5 new sites throughout Ireland • Feature an 1) innovative schools’ programme including pre-events and workshops and a 2) novel citizen science project that is ‘co-designed’ with local schools • Embark upon a new strategy of ‘research by stealth’ to significantly increase and diversify its audience Our largest ERN programme to date will showcase the wonderful research being undertaken in Cork and further afield and will demonstrate the varying ways in which research effects change. A dedicated strand of the programme will focus on sustainability research to reflect the strength of our partner organisations in this area and to respond to public interest in the topic. We will go beyond simply showcasing research. We will lead by example by ‘going green’ in 2020 developing an event that is sustainable from conception to fruition and taking steps to limit the environmental impact as much as possible.


Participants :
- Teagasc - The Irish Agriculture and Food Development Authority (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 10000.0 €
- National University of Ireland (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 28865.0 €
- Cork City Council (Irlande) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 6250.0 €
- Cosmos education limited lbg (Irlande) — Partner, beneficiary, Autres, subvention : 3575.0 €
- National University of Ireland (Irlande) — Coordinator, beneficiary, Autres, subvention : 128545.0 €
- British Council (Royaume-Uni) — Partner, beneficiary, Autres, subvention : 16250.0 €
Projet PERFHeart (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Coronary vascular disease(CVD) has been studied for many decades and has been found to be a very complex problem. Despite dramatic medical advances over the last few decades, CVD remain a leading cause of death globally and the number one cause of death in the European Union (EU). Inspite of the tedious and creative work by many expert scientists from many different perspectives, the disease has only partially been understood. The approach that is taken here differs in basic tenets from earlier approaches, in that it starts from a very basic system of study inorder to progressively build higher levels of complexity. It is understood that the vast majority of the life threatening pathologies are associated with an imbalance between the demand in oxygen and the supply provided by the RBCs. This project will start studying the structure of the microvascular geometry and upscale the coronary circulation from there. The microvascular bed will be embedded into a beating heart with all complexities associated with it:contracting muscle fibre, complex fibre architecture, valves, coronary arteries and veins, etc. On that level, the project will multi-stage and multiscale with finite element (FE) modelling of myocardial contraction, deformation and perfusion. The interdisciplinary perspective in this study is strong with contributions from engineers, clinicians and biomaterial scientists. The scope of the study is usage of FE modelling for autoregulation of coronary perfusion which extends the applications of FE model to common pathologies such as ischemic heart disease, infarction or reperfusion issues and devices such as stents or cardiac assist devices, that improve coronary blood perfusion. This project is in line with the European heart health charter to promote research in the field of cardiovascular diseases.

Mots clés : coronary blood perfusion, finite element model, cardiac modeling, beating heart

Participants :
- University of Limerick (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196590.72 €
Projet MIPZ (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Correct positioning of the division plane is essential for the generation of normal offspring. In Caulobacter crescentus, the spatiotemporal control of cell division is mediated by MipZ, a conserved P-loop ATPase forming bipolar gradients with a concentration minimum at the cell centre. Antagonizing the polymerization of the essential divisome component FtsZ, MipZ inhibits divisome assembly near the poles, thereby limiting cytokinesis to midcell. Gradient formation involves a dynamic localization cycle, in which freely diffusible MipZ monomers interact with polar complexes of the centromere-binding protein ParB and then dimerize in an ATP-dependent manner. Dimers dissociate from ParB and are immobilized within the cell through non-specific interaction with chromosomal DNA. Spontaneous ATP hydrolysis triggers disassembly of the complex, releasing MipZ monomers that are recaptured by ParB. How ParB stimulates dimer formation and how DNA-bound dimers inhibit FtsZ assembly is still unknown. We will address these questions by characterizing previously isolated MipZ mutants with FtsZ/ParB interaction defects, using a combination of fluorescence microscopy, two-hybrid analysis, biochemistry, and biophysical techniques such as surface plasmon resonance, microscale thermophoresis or hydrogen-deuterium-exchange mass spectrometry. We will also use synthetic biological and modelling approaches to rebuild the system in a simplistic form to thus gain in-depth knowledge of the function of the different elements.

Mots clés : bacterial cell division, division site placement, ftsz polymerization inhibitor, para mind atpase family, caulobacter crescentus

Participants :
- Philipps University of Marburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 159460.8 €
Projet umCryofix (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Correlative microscopy, connecting live-cell fluorescence microscopy with electron microscopy (EM), is a powerful tool to relate a dynamic cellular process to the relevant cellular ultrastructure leading to better understanding of fundamental mechanisms, and further, the underlying cause of disease. This is not only important for fundamental science but can guide diagnostic and treatment efforts for virtually any affliction, ranging from Alzheimer’s disease, to HIV, to cancer. In this work, I propose a novel microfluidic cryofixation method that enables time-resolved correlative microscopy. The new method dramatically improves the time resolution with which live images can be correlated to EM images by eliminating the need to transfer the sample from the light microscope to a dedicated cryofixation machine. Current state-of-the-art systems require at least one second while preparation times up to a few minutes are common. Here I propose a new microfluidics-based paradigm that will overcome this barrier by carrying out cryofixation directly within the field of view of a light microscope. This method allows a dynamic process to be arrested at a known time, so that it can be correlated to cellular ultrastructure in EM images. This new method is a critical advance for studying dynamic processes such as membrane trafficking, cell division, and synaptic transmission. This action opens vast possibilities for multidisciplinary collaborations between microfluidic and engineering specialists, who developed a new method (Burg group), and experts in microscopy for biological sciences (i.e. within histology, cell biology, structural biology) to advance the fundamental understanding of dynamic cellular processes that occur on the time scale of milliseconds. Through this multidisciplinary work I will become well-established in my future field of interest, microfluidic devices for biological applications, ensuring the best possible career opportunities for me as a group leader.

Mots clés : microfludics, microfabrication, cryofixation, correlative light and electron microscopy

Participants :
- Max Planck Society (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 171460.8 €
Projet InflaBoot (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : CLOSED

Cosmic inflation is one of the most promising explanations for the origin of the structure in the observed universe. However, while quantum-mechanical fluctuations during an early epoch of inflationary expansion provides a remarkably good description of the data, establishing the precise field content during inflation is a fundamental challenge for primordial cosmology. Since it is almost certain that the inflationary era involved physics beyond the Standard Model, this is also an incredible opportunity to learn about physics at the highest energy scales from current and future cosmological observations. On the theoretical side, it is important to classify the signatures of new degrees of freedom in primordial correlation functions to compare with observations. However, progress has been hindered due to the lack of tools to go beyond the simplest of cases. I propose a research and training programme to develop new systematic tools at the interface between scattering methods in de Sitter (dS) space, and, via holography, the conformal bootstrap in the dual CFT picture, to carve out the non-Gaussianities associated to: (1) Regge trajectories of higher-spin fields predicted by string theory/other UV complete theories of gravity (2) partially massless higher-spin fields, both at tree and 1-loop level. This proposal combines my expertise on higher-spin theories, scattering methods on anti-dS and holography with extensive training on various aspects of inflation and CMB physics from world-leading experts at IAS Princeton. The project will be completed at ULB, whose complementary expertise on higher-spins and holography will provide fertile ground to transfer my knowledge gained from the outgoing phase and continue the directions generated by the project. The importance of the project outcomes to cosmology and high-energy physics, as well as the experience gained, will facilitate me in obtaining a junior researcher position in Europe – the natural next step in my career.

Mots clés : a ds, conformal field theory, cosmic inflation, string theory

Participants :
- Université Libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 240530.4 €
- Institute for advanced study - louis bamberger and mrs felix fuld foundation corporation (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet WEY-CRISP (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Creating environments that foster young people´s wellbeing is one of the current priorities for the European Union. Increasingly such efforts are conceptually framed through a focus on positive paradigms across the life course. Social science evidence indicates that supportive relationships with significant adults are important determinants of young people’s wellbeing and future life chances. Recently the significance of non-parental adults in shaping youth wellbeing has been examined. In this vein, WEY-CRISP focuses on the contribution of teachers to the construction and maintenance of wellbeing. Understanding the significance of teacher connectedness for youth has been constrained by inconsistencies in definitions and measures. Consequently, the character of the contribution of such relationships to wellbeing (from teachers as complementary sources of instrumental support to key mentors for youth) is also unclear. WEY-CRISP will: 1.Investigate the determinants of teacher connectedness and potential for being a protective health factor, including diverse groups of youth (ethnicity, age, gender) and different contexts e.g. low parental support. 2.Clarify on the nature of teacher connectedness and develop an effective measure for its assessment that taps into the main components for wellbeing. 3.Generate synergistic links between approaches in education and health research. The investigation will use a mixed methodology (quantitative and qualitative), including youth centred participatory research strategies. WEY-CRISP will link with a multidisciplinary, international network of experts on adolescence via the WHO (Europe) cross-national HBSC study, aiding in the maximization of the impact across the European Union and enhancing the European Research Area. The experienced researcher will access significant methodological training and career development opportunities including leadership skills via engagement with policy makers and researchers.

Mots clés : adolescent well being, school and teacher connectedness, health assets

Participants :
- University of Hertfordshire (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet CroProLITE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

CroProLITE aims to evaluate the Islamic Green Revolution (IGR) thesis–involving crop introduction from eastern and central Asia to the Mediterranean by Early Islamic empires–through a microregional comparative study of 1st millennium CE agropastoral change. It applies archaeobotanical and biomolecular methods to numerous well-preserved plant macrofossils and herbivore dung pellets from rubbish dumps at nine Roman-Early Islamic trading sites in the Aravah valley on the southern border of modern Israel-Jordan and the adjacent Negev Highlands. Some sites are associated with Early Islamic agrotechnological introduction of qanat irrigation, indicating likely Early Islamic crop introduction there. Capitalizing on similarity of archaeological context alongside dissimilarity of historic-economic context, the comparative method will be applied to these regions and periods. To identify seasonal agropastoral rhythms, an extensive and innovative multi-proxy methodological study will analyse contents of ancient dung pellets from the sites. New datasets generated from plant remains and coprolites will allow synthesis of agropastoral developments at seasonal to millennial scales and framing of findings in terms of ancient economic history and Mediterranean deep history. Lessons on agricultural continuity and change from the Negev-Aravah in the face of first millennium CE global climate change, plague and cultural conflict hold promise for improved understanding of historical effects of environmental stressors. In unearthing such lessons, CroProLITE will contribute to long-term environmental risk assessment and reflection on our own society’s future, offering a model for environmental humanities research. Host supervisor and leading palaeoproteomics scholar Matthew Collins will guide biomolecular archaeology training through coprolite analysis, alongside multiple mentors for ancient economic history and Mediterranean history-archaeology, including career mentor Cyprian Broodbank.

Mots clés : archaeobotany, biomolecular archaeology, archaeological science, multi proxy archaeology, crop diffusion, agricultural innovation, coprolite, environmental archaeology, roman archaeology, islamic arch

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet BS_Night_140926_150925 (Horizon 2020, appel à projets 2014)
Action : European Researchers' Night
Statut du projet : CLOSED

Crossing Borders, pushing the limits of knowledge, inventing new methods, technologies, materials to improve our life. That´s what research is all about. What is needed for this is simple: a clever mind and curiosity. With the slogan Crossing Borders –there is a researcher in all of us we want to show how diverse research careers and findings can be and how they impact the everyday life. Furthermore, during the European Researchers´ Night we want to advertise research as a career especially to young people. This is why we are bringing researchers into town - research is right at home in Braunschweig. Our region is one of the most research intensive regions in Europe, boasting the highest density of scientists. To make this visible we are embarking in a bet: we want to assemble at least 1,000 researchers at a so-called Researcher-Flashmob. We expect around 10,000 visitors who are invited to be part of the bet before the event and who can be part of a whole range of small events on the night to get up-and-close with the researchers. Events include playing games together, an elevator pitch, hands-on-experiments or a Science Slam. This way we are encouraging people to enjoy research and show how research makes life easier. At the same time we dispel the myth surrounding researchers. An extensive awareness campaign before the event will help spreading the message even beyond the night itself. After the campaign we expect at least 85,000 people to know about the European Researchers´ Night (ERN) and its objectives. The Haus der Wissenschaft (House of Science) is the interface between all universities, research institutions and the city, economy, cultural and educational institutions of Braunschweig. Together with the TU Braunschweig, one of the oldest TUs in Germany and the city of Braunschweig we have the ability and experience to make an event like this run smoothly.

Mots clés : researchers night, researcher flashmob, crossing borders, science communication

Participants :
- Technische Universität Braunschweig (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 12500.0 €
- Haus der wissenschaft braunschweig gmbh (Allemagne) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 176500.0 €
Projet TRILLION (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

Crystalline structure is a unique environment for strong-field QED effects involving both high-energy charged particles and photons. A small piece of crystal material could be used as an intense source of X- and gamma-ray radiation, a positron source, a beam manipulation instrument, a compact detector and a compact wake-field accelerator as well. Consequently, a crystal could be useful for a wide range of applications in accelerator physics, high-energy frontier physics, nuclear physics, cosmic-ray detectors, dark matter search and radiation therapy. The implementation of both physics of electromagnetic processes in oriented crystals and the design of specific applications of crystalline effects into Geant4 simulation toolkit as Extended Examples to bring them to a large scientific and industrial community and under a free Geant4 license is the main goal of the project. The implementation of the following innovative applications into Geant4 will be mainly focused on: 1. Crystalline deflector to extract a charged particle beam from an accelerator (electron synchrotron, hadron collider) to supply fixed-target experiments by an intense low-emittance beam. 2. Crystalline source of intense coherent hard X-ray and gamma radiation, crystalline undulator. 3. Crystal-based hybrid positron source for both linear and circular e+e- colliders (ILC, FCC-ee) as well as for muon colliders. The outgoing research phase of this MSCA-GF project at the Korea Institute of Science and Technology Information as well as training at Korea Advanced Institute of Science and Technology and University of Science and Technology and participation in high-tech Daedeok Innopolis exhibitions will bring the ER to a considerably higher level of competence. During the incoming phase at INFN Division of Ferrara supplemented by the secondments to DESY and IJClab the ER will finally reach his professional maturity and independence as well as will acquire a lot of new ideas to submit them as ERC proposals or to create high-tech startups and a lot of professional contacts to realize them.

Mots clés : geant4, electromagnetic processes in oriented crystals, crystal channeling, x ray and gamma radiation source, positron source

Participants :
- Stanford University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Korea Institute of Science & Technology Information (Corée du Sud) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- National Institute for Nuclear Physics (Italie) — Coordinator, beneficiary, Recherche, subvention : 249465.36 €
Projet MANET (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

Curbing greenhouse gas emissions is a challenge of the utmost importance for our society future and requires urgent decisions on the implementation of clear-cut climate economic policies. Integrated Assessment Models (IAMs) allow to explore alternative energy scenarios in the next 30-70 years. They are key to support the design of climate policies as they highlight the nexus between climate modelling, social science, and energy systems. However, the use of IAMs to inform climate policies does not come free of controversial aspects. Primarily, the inherent uncertainty of IAMs long-term outputs has created several difficulties for the integration of the modelling insights in the policy design. Modelling outputs diverge across IAMs models quite dramatically when they are asked for example to quantify the uptake of key technologies for the decarbonisation, such as renewables and carbon capture and storage. Uncertainty in IAMs descends from lack of knowledge of the future and from IAMs incomplete representations of the future. Uncertainty cannot be removed, but reduced, understood, and conveyed appropriately to policy makers to avoid that different projections cause delayed actions. This project aims to fill this gap providing a methodology which defines the sources of uncertainty, either due to IAMs inputs or IAMs structure, and quantify their relative importance. The methodology will be embodied in an emulator of IAMs, MANET (the eMulAtor of iNtegratAd assEssmenT models) formulated using machine learning techniques to reproduce IAMs outputs. The project will provide a proof of concept of MANET focusing on the uptake of key decarbonisation technologies. The emulator will provide a simplified version of the IAM outputs as a response surface of the model to any variation of the inputs. MANET will be a flexible tool for policy makers and scientists for a direct comparison of IAMs with no limitation of the solution domain.


Participants :
- Politecnico di Milano (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171473.28 €