Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet OASYS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Neurological diseases are now the leading contributor to the global health burden, affecting one in three individuals worldwide. In response to this critical issue, the development of innovative organic mixed ionic-electronic conductors (OMIECs) that emulate the ion-regulated electronic conductivity and dynamics of biological ion channels when implemented in organic electrochemical transistors (OECTs) has paved the way for electronic devices capable of replicating neuronal functionality, namely conductance-based organic electrochemical neurons (c-OECNs). Despite the progress towards emulating biological neuron functions, current c-OECNs are limited by their inability to generate biologically plausible spike frequencies and their high power consumption, which hinder their integration with biological systems. In this sense, OASYS plans to overcome this challenge by developing innovative OMIECs with optimized ambipolarity characteristics and fabricating wearable and biorealistic c-OECNs that can be fully integrated with biological systems. This will be realized by using rationally designed bithiophene imide (BTI)-based polymers that operate at low gate voltages, enabling faster OECT devices with reduced power consumption and enhanced spike frequencies. OASYS integrates cutting-edge polymer design, advanced material characterization, and innovative device engineering in an application-oriented approach to tackle critical challenges such as antiambipolar tunability, selective sensing, wearability, and biointegration.

Mots clés : organic mixed ionic electronic conductors, organic electrochemical transistors, antiambipolarity, neuromorphic perception, conductance based organic electrochemical neurons, biohybrid synapses

Participants :
- Forschungszentrum Jülich (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Linköping (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 236340.0 €
Projet ET-CPAARC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Radiative cooling provides a sustainable solution for reducing the growing global energy consumption, particularly in cooling buildings which today alone constitutes around 10% of the global electricity consumption. In brief, radiative cooling spontaneously cools objects by radiating heat (thermal emission) to the cold outer space. While intense research has focused on developing materials with high radiative cooling efficiency, less attention has been paid on the need to be able to regulate the cooling power to adopt to varying outdoor temperature conditions. The host group recently demonstrated tuning of radiative cooling based on varying the redox-state of a conducting polymer thin film, but still with modest emissivity tuning of 25-40%. This project aims to significantly improve upon such tuning capability by introducing a novel concept which couples a Fabry-Perot optical cavity to a conducting polymer plasmonic antenna arrays. We aim to achieve near-perfect thermal emission in the oxidized (metallic) state of the polymer and to essentially switch off the thermal emission by electrically switching the polymer mirror and antennas to their reduced (dielectric) state.

Mots clés : radiative cooling, plasmonics, antenna arrays, conducting polymer, thermal emission

Participants :
- Université de Linköping (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 236340.0 €
Projet DMOptfES (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The central challenge in energy systems is to balance cost-efficiency, environmental responsibility, and living standards. Multi-objective optimization in such systems is critical for striking compromises among stakeholders and ensuring competitiveness and sustainability. As energy systems face uncertainty, volatility, and environmental regulations, holistic optimization becomes more critical.  However, three main challenges currently hinder energy system optimization: complex models demanding substantial computational power, a lack of holistic and robust approaches, and the use of real-time data for proper operation and analysis. Although each of these challenges has been addressed individually, no contribution was able to bring them all together in a consistent methodological framework. This is the main objective of this fellowship.  This fellowship will be conducted at IST/University of Lisbon under the supervision of Prof. Henrique Matos, and aims to bridge these gaps by integrating machine learning, systems optimization, uncertainty analysis, and real-time operation. It seeks to develop advanced surrogate generation techniques, emphasize system integration and holistic analysis, optimization under uncertainty, and the use of real-time data for operation. These methods will be applied to real industrial challenges in an industrial secondment. This research project will develop methods and tools to address such challenges and contribute to a sustainable, profitable, and responsible European economy.

Mots clés : energy systems engineering process systems engineering

Participants :
- Université de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
- Emissium sa (Suisse) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet FOAM 3D (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Liquid foams possess distinct structural and mechanical properties, making them essential to various industries ranging from food production to ore flotation. When subjected to shear, foams exhibit complex rheological behaviors: responding elastically to small deformations, plastically to larger ones, and flow with a shear-rate-dependent viscosity once their yield stress is exceeded. These behaviors are governed by local plastic rearrangements of bubbles. Although much is known about local rearrangements in 2D foams, the understanding of 3D foams remains limited. This knowledge gap hinders accurate predictions of dynamical heterogeneities in plastic rearrangements, often leading to trial-and-error approaches when engineering foam properties for applications. This project aims to bridge that gap by combining X-ray tomographic microscopy with numerical simulations and advanced AI techniques. I will begin by analyzing data from fast X-ray tomographic microscopy experiments combined with rheological measurements, which simultaneously capture the macroscopic response of 3D foams and the detection of plastic rearrangements at the bubble scale. However, the limited temporal resolution of X-ray tomography necessitates the development of experimentally informed numerical simulations to further explore foam dynamics. Predicting the occurrence of plastic rearrangements remains a significant challenge. To address this, I will develop graph neural networks (GNNs) capable of predicting the spatiotemporal occurrence of plastic events in foams during a secondment at a company specialized in AI. GNNs have already proven effective in predicting plastic events in glasses, making them an ideal tool for this task. Since foams are an athermal analog of amorphous solids, insights from this research will be applicable to other yield-stress materials, where the interaction of localized plastic rearrangements is crucial for predicting fracture and flow.

Mots clés : foams, amorphous solids, yield stress fluids, computational modelling, rheology, artificial intelligence

Participants :
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université Grenoble Alpes (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 242260.56 €
- Bull (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet OXBLOLYTE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The EU’s notion to become climate neutral in 2050, as per the EU Green Deal, strives to transform the economy through advancements in clean renewable energy. While rechargeable Li-ion batteries sustain the current market for energy storage, they cannot continue to achieve the transformative scale of improvement required due to the finite supply of lithium, and their limited energy storage capacities, among others. Sodium-air batteries (NaBs) provide an attractive alternative due to the abundance of sodium – thus low cost – and their lightweight porous air cathodes to reach greater energy densities. Today’s traditional electrolytes are unstable towards Na metal and radical species generated during cycling, allowing oxygen crossover to the anode, which results in battery failure. Moreover, their liquid nature leads to evaporation and leakage issues. OXBLOLYTE Postdoctoral Fellowship will overcome these challenges by developing novel solid-state electrolytes based on Polymer of Intrinsic Microporosity membranes combined with conducting Organic Ionic Plastic Crystal materials. In parallel to these practical concerns, OXBLOLYTE will unravel mechanistic understanding of solid-state NaBs– a field currently unexplored - to allow the correct choice of electrolyte. The research fellow, Dr. Yahia (with expertise in polymer membranes), will conduct the OXBLOLYTE project at CIC energiGUNE (Spain) with the host supervisor, Dr. Ortiz-Vitoriano (pioneer in the relevant research field) which includes mechanical property studies under the supervisor of Dr. Sardon (with expertise in polymers) at Polymat (Spain). OXBLOLYTE facilitates the transfer of 3 I’s knowledge whilst diversifying Dr. Yahia’s networks and leadership skills to further advance his career perspectives and employability. As a result, OXBLOBLYTE will lead to research outputs that will be disseminated to the general public, scientific community and industry with the final aim to enlarge its exploitation potential.

Mots clés : non aqueous chemistry, solid state electrolyte, batteries, na air, climate neutrality

Participants :
- CIC energigune (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet ISLINGTON (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Moorings of floating oil and gas (O&G) structures exhibit surprisingly large failure rates. In the O&G industry this problem is simply handled by redundancy in the design. It is unlikely that marine renewables - in order to obtain a competitive levelised cost of energy (LCOE) can afford such redundancy in the mooring design. ISLINGTON has the overall objective to reduce uncertainties in estimated fatigue damage of mooring cables due to soil-cable interaction in the touch down zone (TDZ); and subsequently lower the economic cost of mooring systems for marine renewables. To achieve this objective, the following research actions will be carried out: 1) Improving the numerical modelling of the cable-soil interaction in the TDZ for mooring cables by allowing for time-dependent granular soil dynamics. This will be done by creating an Application Programming Interface (API) inside a granular particle soil solver to allow a two-way coupling to a mooring cable solver providing position and motion of the mooring cable. 2) Generating experimental data for mooring line trenching to be used for validation. This will be done by forced oscillations of a cable in a wave flume with sandy bottom and log the development of the trenching under different forcing. 3) Numerical investigation of the effect of trenching on fatigue of mooring cables. This will be done for standard test cases such as the IAE Task 30: OC3-OC6 test cases. The work proposed is well beyond state-of-art with respect to ground modelling of mooring cables in that the bathymetry will be time-dependent so trenching will be modelled together with the nonlinear cable response. The work on trenching effect to mooring line fatigue and snap load generation and dissipation will be the first such investigation. The resulting papers, models and experimental datasets will be released open-access in line with the open science practice.

Mots clés : mooring, cable, finite element method, granular soil, multi physics dynamics, fatigue, damage, hydrodynamics, renewable energy, offshore wind

Participants :
- Université de Vigo (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Aalborg (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
- Sigma energy & marine ab (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet CRISPRGlue (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Glioblastoma multiforme (GBM), constituting 50.1% of CNS tumors, is the most frequent malignant brain cancer with a median survival of 14.6 months, highlighting the urgent need for more effective treatment strategies. The rise of effective gene therapies especially CRISPR/Cas (“clustered regularly interspaced short palindromic repeats/associated protein 9”) based gene editing technology has sparked optimism for treating GBM. Given the ongoing challenges with CRISPR-Cas gene therapy, such as effective delivery across the blood-brain barrier (BBB), off-target effects, and immune responses associated with Cas9, this research proposal (CRISPRGlue) aims to develop "nanoglues," a novel class of engineered nanogels for targeted delivery of CRISPR tools followed by ultrasound triggered release to address GBM treatment challenges at a European level. The gene editing efficacy of the CRISPR/Cas tools delivered by “nanoglues” will be preliminary investigated as a “proof of concept” by knock-down approach with GFP expressed U87MG cell line followed by targeting EGFR genes which are highly overexpressed in GBM sites. The project unites a dynamic researcher, Dr. Soumen Ghosh, with expertise in synthetic organic chemistry and protein science, alongside POLYMAT, an innovative institute focused on biomedical solutions utilizing nanogels for the controlled release of the CRISPR/Cas9 complex. Prof. Marcelo Calderón, the host supervisor, is a globally recognized researcher leading the “Responsive Polymer Therapeutics Group (RPTG),” a top team specializing in drug delivery using nanogels (NGs). The multidisciplinary expertise required for CRISPRGlue will be complemented by the Smart Bio-Interfaces group led by Prof. Gianni Ciofani. CRISPRGlue will advance the researcher’s career in both academic and non-academic fields by developing non-viral gene delivery systems to facilitate curative gene editing, empowering him to drive the translation of laboratory findings to pre-clinical trials.

Mots clés : non viral delivery nanogel glioblastoma molecular glue crispr cas9 gene editing

Participants :
- Université du Pays basque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209914.56 €
- Basque center for macromolecular design and engineering polymat fundazioa (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Italian Institute of Technology (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet ExoDiagAI (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The ExoDiagAI project is at the forefront of addressing a critical challenge in modern healthcare—early diagnosis and effective management of breast cancer, particularly the aggressive and elusive triple-negative breast cancer (TNBC) subtype. TNBC lacks well-defined molecular targets, hindering treatment options. Exosomes, a subset of extracellular vesicles with unique functions, hold great promise as diagnostic and prognostic markers for various diseases, including cancer. These tiny vesicles are abundant in biological fluids but have been underutilized due to the absence of a cost-effective isolation protocol. Our primary goal is to develop a microfluidic device, integrating nano-lateral displacement arrays with a Raman biochip, to identify exosome biomarkers specific to TNBC and translate this knowledge into clinical practice. This project's main objectives encompass creating the microfluidic device, assessing its surface-enhanced Raman spectroscopy (SERS) capabilities, conducting Raman fingerprinting of exosomes from in vitro cell cultures and patient samples, and employing chemometric analysis to discriminate biomarkers. The distinctive Raman fingerprinting associated with exosomes serves as a promising prognostic and diagnostic marker. By introducing 3D printing SERS technology, we aim to enable real-time monitoring, shedding light on exosome structural integrity. This interdisciplinary project combines organic, inorganic, nano, computational, spectroscopic, and molecular biology techniques, culminating in innovative device fabrication. Ultimately, the ExoDiagAI project holds the potential to revolutionize early breast cancer diagnosis through exosomal biomarkers, aligning with the EU's sustainable development strategy for advanced diagnostic platforms and fostering the career of a promising researcher. This endeavor marks a pivotal step towards enhancing the detection and management of TNBC, addressing a pressing healthcare need.

Mots clés : 3d nano dld arrays raman micro biochips exosomal trop2 biomarkers triple negative breast cancer tnbc personalized medicine

Participants :
- Wroclaw Medical University (Pologne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Leibniz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet ELDOPP (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Future quantum technologies promise to deliver unprecedented computing power, guarantee secure communications, and yield ultra-high precision measurements. The key-element of all quantum optical technologies is the single photon emitter; however, state of the art single photon sources still suffer from a slow photon emission rate hampering the application of quantum technologies in our everyday life. Moreover, in quantum optics, it is essential to be able to analyze quantum signatures of the emitted light from quantum dots (QDs) and current experimental configurations offer limited capabilities for the metrology of quantum-light sources. Therefore, ELDOPP will target the development of a novel approach based on electrical doping of perovskite quantum dots (QDs) to boost their single photon emission properties and the implementation of a new detection system for the complete characterization of quantum optical properties of light emitted by QDs. The first aim of the project will be achieved through the realization of a solid-state device where an external electric field is directly applied to the perovskite QDs using a parent structure of field-effect transistor (FET) to generate highly charged excitons with fast decay rate. Furthermore, ELDOPP will take advantage from the fact that perovskite QDs provide the fastest decay rate among the known QDs so far, offering the opportunity for the realization of the fastest single photon source at room temperature until now. The second aim of ELDOPP will be accomplished via the implementation of a detection system based on a single photon avalanche diode (SPAD) array detector. The data collected with this system will provide a complete characterization of the analyzed single photon emitter giving information on the lifetime, antibunching effect and photon indistinguishability enabling also quantum-imaging microscopy.

Mots clés : colloidal quantum dots, nanocrystals, single photon emitters, spad array

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 172750.08 €
Projet PHYLOMUSIC (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The capacity to perceive and produce music – musicality – has ancient but mysterious roots. While musicality is nearly ubiquitous across human ages and cultures, it seems to be scarcely developed in non-human primates such as rhesus monkeys. This is surprising given that rhesus monkeys are not only one of our closest relatives, but also a fundamental model for human auditory function and communication. PHYLOMUSIC proposes an innovative approach to the study of musicality in non-human primates (macaca mulatta). Rather than focusing on isolated musical features such as tone-order or rhythm, it combines them to form proto-musical patterns. PHYLOMUSIC takes (i) the detection of proto-musical patterns, and (ii) their memorization as two pillars of musicality. With this, PHYLOMUSIC proposes a series of non-invasive electroencephalography (EEG) studies aimed to test whether and how proto-musical patterns are detected and memorized (in both short- and long-term) in rhesus monkeys and (as a comparison) in humans. Combining notions from comparative research, music, auditory computational neuroscience, and state-of-the-art brain signal analysis, PHYLOMUSIC is a multi-disciplinary project that has the potential to impact upon three distinct research areas. First, it will shed light upon the mysterious evolutionary origins of musicality, unveiling whether music processing is phylogenetically conserved, and how mnemonic systems may have evolved to support musicality in humans. Second, it will introduce novel analytical approaches to the fast-rising field of non-human primate neuroimaging. Last but not least, it might provide an empirical ground for realistically testing – at the neuronal and circuitry level – the widespread use of music in clinical settings, having noteworthy implications for human health.

Mots clés : music, electroencephalography, pattern, auditory perception, auditory memory, phylogeny

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 188590.08 €