Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet DeeBMED (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Diseases characteristic for modern western civilization, such as cancer, diabetes or cardiovascular disorders, lead to millions of deaths per year in the European Union. In order to decrease this enormous quantity, medical imaging should be widely available at early diagnostics and every stage of a therapy. Nowadays, there are various diagnostics techniques including CT, PET, MRI, however, analysis of a medical image is time-consuming and expensive. Development of new effective automatic tool for medical imaging will appear a new strategy in highly specific control of incidences and disease progression. The aim of the DeeBMED project is to develop powerful automatic medical imaging tool that can cope with main problems associated with complex images like medical scans: multimodality of data distribution, large number of dimension and small number of examples, small amount of labeled data, multi-source learning, and robustness to transformations. In this project I will propose a probabilistic framework that combines different deep neural networks (DNN), such as feedforward nets, convolutional nets, Gaussian processes. I will apply DNN to model probabilistic relationships among a medical scan, a disease label, and hidden variables representing latent factors in data. In the case of a small sample size DNN are prone to overfitting. A possible remedy for that is Bayesian learning, however, it is still challenging how to apply it to DNN. In this project I will use various approaches: modelling weights uncertainty, Dropout, Bayesian Distillation. As the result I predict identification of the first highly effective medical imaging analysis tool that in the future will be widely used by radiologists in medical institutes in the whole EU. Novel automation will drastically reduce time and costs of analysis and provide more accessible diagnostics. The project will be carried out at the University of Amsterdam, under the supervision of Prof. Max Welling.

Mots clés : deep learning, bayesian learning, variational inference, medical imaging

Participants :
- University of Amsterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet COSMOS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Diseases of the heart and circulatory system are the main cause of death in Europe (over 4 million deaths each year). In particular, heart failure (HF) accounts for almost 1.1 million deaths each year. In early ’90 there was the formal recognition that inflammatory mediators are activated in the setting of HF by a sentinel description of inflammatory cytokines in patients with heart failure. After that, a growing interest in the role of biomarkers in regulating cardiac structure and function, particularly regarding their potential role in disease progression in heart failure, raised up. Nowadays, there are evidences on that. Generally, biomarkers are determined mostly in plasma or in blood, rather than in saliva. In fact, despite of that very few of them have been currently studied in saliva, saliva has to be considered as an important diagnostic and prognostic medium for minimally invasive tools. Indeed a great progress in disclosing the complete salivary proteome has carried to the identification of more than 3000 different proteins. Scope of this project is to develop a tool for HF-biomarkers detection through saliva. The idea is to combine the knowledge of the experienced researcher in microelectronics and CMOS imagers with the competences of the hosting laboratory on bioMEMs for biomarkers immobilization to develop an innovative point-of-care system for a fast and precise detection of HF-biomarkers. To this end the hosting institution and the experienced researcher complete each other and make the research and development on this cross related filed feasible. The proposed device will allow a mass screening for the prevention of HF and other pathologies related to the cardiovascular system. Within this project, the experienced researcher will be able both to enlarge her knowledge in the design of CMOS imagers by implementing innovative photon detection techniques and to approach a growing branch of microelectronics, such as the bioMEMs one.

Mots clés : biomems, optial readout, point of care

Participants :
- Université Claude Bernard - Lyon 1 (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet NeuroVU (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Disorders of the central nervous system are one of the grand health challenges of this century. Therapeutic development, however, remains limited by poor understanding of the brain, including of the neurovascular unit (NVU). The NVU acts as the gatekeeper between blood and brain for metabolites, disease agents, as well as drugs. Much research has relied on animals or simple cell models that recapitulate neither the cellular ensemble nor the environment of the NVU. Emerging Organ-on-Chip microsystems promise to overcome these limitations, but to date fall short on the relevance of cells used and the lack of continuous monitoring capabilities for chemical markers, metabolic conversions, and pharmacodynamics. My objective in this project is to develop the first NVU Organ-on-Chip integrating human-normal cells as well as biophysical and biochemical sensors for real-time monitoring, termed NeuroVU. I propose to rely on primary and induced pluripotent stem cells, which can achieve in-vivo-like properties, and off-stoichiometry thiol-ene-epoxies (OSTE+) as the enabling technologies. OSTE+ is a versatile polymer uniquely suited to supersede the prevalent polydimethylsiloxane/glass paradigm for the innovative system integration approaches needed here. I will first characterize and optimize it for compatibility with biological and sensor components. I will build on these component insights with microsystems integration to develop NeuroVUs featuring co-culture of NVU-normal cells, continuous monitoring of relevant ions & metabolites in addition to trans-endothelial electrical resistance, and tissue-like hydrogel structures. I will leverage collaborations with resident experts in materials and biology as well as my own strong background in microsystems integration to realize this highly interdisciplinary project. Ultimately, the NeuroVU will allow for unprecedented insights on NVU chemistry and has the potential to significantly accelerate pharmaceutical development.

Mots clés : organ on a chip, microsystems integration, neurovascular unit, microfluidics, biochemical and biochemical sensors, microfabrication, polymer and hydrogel materials

Participants :
- KTH Royal Institute of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185857.2 €
Projet HELICOMBX (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Dissipationless electrical transport is a key paradigm to reduce energy consumption in our society. Recent advancements in condensed matter physics have revealed that there exist ballistic transport channels at the surface or the edge of topological insulators. These states are preserved by time-reversal symmetry and robust against back scattering. Exploiting topological insulators is therefore a major step for future nondissipative nanoelectronics. Nevertheless, such a topological phase of matter has been discovered in very few kinds of materials so far. Most of the existing materials are difficult to fabricate, which limits scientific endeavor to explore their properties and also future application. Recently, several theoretical studies have demonstrated that atomically thin graphene or other two dimensional crystals may become two dimensional topological insulators (quantum spin Hall insulators) by inducing large spin-orbit interaction. These materials are rich of novel physics and attract growing attention in their own right. Moreover, they are easy to prepare by mechanical exfoliation, which facilitates to apply them to real nanoelectronics devices. HELICOMBX is the first project which aims at establishing a basis for dissipationless electronics and spintronics with graphene and transition metal dichalcogenides and unifying physics in topological phase, spintronics and two dimensional crystals. The project is divided into three parts. First we will induce large spin-orbit interaction in graphene by adatoms deposition and heterostructures construction with transition metal dichalcogenides. Spin-orbit interaction of each system is then measured by magnetotransport measurements. Second we will exploit these functionalized two dimensional crystals for spintronics devices. As the final part, quantized conductance will be measured as a signature of the edge states, and we will integrate it into Josephson junctions to observe the Majorana fermions.

Mots clés : topological insulator, quantum spin hall insulator, graphene, transition metal dichalcogenide, heterostructure, adatom

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 173076.0 €
Projet Coastal Hypoxia (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Dissolved oxygen is an essential substance for a large portion of marine biota. Hypoxia, the reduction of dissolved oxygen concentrations to levels which are detrimental to the health of aerobic organisms, is currently expanding throughout the world's coastal areas, creating a negative impact from both the environmental (e.g. reduced biodiversity, reduced population growth, formation of 'dead zones') and economical (loss of fisheries) perspectives. Through the development and usage of local to global scale biogeochemical models, this research addresses past, present, and future formation of hypoxic 'dead zones' as a result of human-induced nutrient loadings and climate change. These topics are relevant for both industry and society, as they include the effects of changing river nutrient export to coastal marine ecosystems on the increasing frequency, extent, and duration of hypoxia. These studies will serve to further constrain nutrient reduction strategies and their effect on the amelioration of hypoxia in various coastal environments.


Participants :
- Utrecht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet DiverseJust (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

DiverseJust takes a novel approach to studying Denmark’s contentious policy debate on welfare and the criminal justice system in times of increased immigration and cultural diversity. Most current research focuses on either welfare or the criminal justice system, as theoretically separate entities. However, following Loic Wacquant’s work, this project examines policy changes in welfare and the criminal justice system, examining them as a compound of intimately connected policies that evolve in tandem in response to increased diversity in welfare states. I argue that to fully understand the evolution of welfare and criminal justice systems, we need to consider race and ethnicity as central variables that shape state response to deviance and poverty. Using expert interviews, the research project will explore (a) the impact that increased diversity has on the Danish welfare system, especially for immigrants; and (b) the impact that increased diversity has on the Danish criminal justice system. Ultimately, this study asks (c) how Denmark, a classic Scandinavian welfare state, may change in response to the challenges of increased cultural diversity.

Mots clés : criminal justice, welfare, immigration, policy, expert interviews, neoliberalism, diversity

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet DYN-SEAM (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Dr. Bin Wu is a Chinese national, trained in Applied Mechanics and Multi-physics in China, Germany, and Italy. He is applying for a two-year MSCA Fellowship to conduct the DYN-SEAM action at NUI Galway, Ireland. Due to striking advantages such as rapid response and large deformation under electric stimuli, and significant changes of dynamic characteristics induced by biasing fields (pre-stretch, electric stimuli, etc.), soft electro-active materials (SEAMs) have found multiple and practical applications in the real world, including actuators, energy harvesters, biomedical devices, flexible electronics, tunable resonators, and wave devices. However, a systematic understanding of their dynamic behaviours is still lacking, creating a bottleneck to innovation. The action aims at conducting an in-depth investigation of the effects of key factors (inhomogeneity, anisotropy, viscoelasticity, fluid-solid interaction, periodic structures) on the dynamic characteristics of SEAMs under biasing fields, with special attention in exploring promising applications, such as ultrasonic non-destructive testing and ultrasound elastography, smart design of self-sensing actuators, tunable resonators, and soft intelligent wave devices. The action mixes ad-hoc theoretical modelling with experimental tests and numerical simulations, by taking full advantage of the host and partner institutions' expertise and facilities, and experience in scientific management, intellectual property, etc. Secondments include a period at an acoustics laboratory (academic) and another at an enhanced hearing company (non-academic). This international, inter-sectoral and inter-disciplinary action will enable novel technological advances in material/life science and engineering—contributing to Europe 2020 'Innovation Union' initiative and European excellence. It will allow the researcher to grow as a world-class leader for these emerging fields, with a unique blend of expertise and hands-on experience.

Mots clés : soft electro active material, dynamic behaviour, experimental test, finite element simulation, self sensing actuator, tuneable resonator, soft intelligent wave device, ultrasound elastography

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196590.72 €
Projet Next-COMM (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Dr. Christos Vezyrtzis is currently employed in the US as an IBM Research Staff Member, after concluding his PhD at Columbia University in the City of New York! Instead of a life-long career in the US, he decided to take the step back to Europe. Through his unique expertise in continuous-time digital signal processors, he will acquire a career in Europe, establishing himself in the field of next-generation communication circuits. The primary technical focus is the novel event-driven design approach to achieve maximum energy efficiency for the next generation digital communication circuits. This will lead to a drastic reduction in power cost, environmentally friendly products and significantly prolonged operation time. The novel radios will have a cleaner emitted spectrum, less interference which leads to higher data rates (closer to the theoretical limit). Improvement in energy-efficiency will help the European market get one step ahead of the competitors, mainly in the US and Asia. Infineon, as the host organization, is highly supportive to this idea gaining one of the top-level experts in asynchronous and continuous-time digital circuits to strengthen the European Semiconductor Industry. Such effort will greatly benefit from Dr. Vezyrtzis’ extensive skills in the new and upcoming field of continuous-time digital circuits. The Marie S. Curie funding gives Dr. Vezyrtzis the freedom to develop his own strategy to re-integrate in Europe while gaining additional industry experience and support an application oriented research project for future communication solutions. The career goal for the researcher is to find a long-term position in European research, starting in industry to get an additional set of capabilities while investing his know-how in the project. At the end of the Marie S Curie fellowship he will have clarity about his further path in Europe – being qualified for industry as well as for academia.

Mots clés : re integration us to europe, next generation digital communication circuits, energy efficiency, wireless communication for the future, ctdsp  continuous time digital signal processors

Participants :
- Infineon Technologies (Austria) (Autriche) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 166156.8 €
Projet TRAPS-2D (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Dr. Marquez proposes a new approach to improve the performance of 2D materials: the defect-engineering. This approach aims to investigate the critical issue of defects implication on the 2D semiconductors operation to solve the low performance and to accomplish a future CMOS co-integration. Electrically activated interfaces, surface and oxide states have demonstrated not only to reduce the device performance but also making the device to behave in a determine operation. Surface defect have shown metal workfunction pinning and therefore formation of Schottky barriers at the contact-semiconductor interface. In addition, depending on the energy level these defect, they can contribute like donor or acceptor dopant or like generation-recombination (trap) centers. In this regard, the fabricated devices would operate differently, presenting n-type, ambipolar or p-type behavior and accumulation or inversion operation modes. Fast operating, normally-on or normally-of devices can be addressed controlling the defect implications. The understanding and control of these defect states and impurities in 2D semiconductor systems is an essential area of research, and the first step is to develop the metrology tools to accurately quantify defect densities and distributions gaining further insight into the possible origin of the defects states. “TRAPS-2D” is a proposal to systematical study of defect (trap) states implications on 2D materials. Its novelty resides in the control of these defects to force the fabricated devices to operate in a specific mode and therefore control their performance. Additionally, the proposal holds an important technological transfer aspect considering the co-integration of these 2D materials in the standard CMOS processes to open the doors to ultimate commercial electronic applications.

Mots clés : cmos, transistors, 2d materials, tmds, mos2, semiconductor reliability, electrical characterization

Participants :
- University System of Taiwan (Taïwan) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Granada (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165666.88 €
Projet SUNNRL (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Drawing on the expertise from the applicants’ publications, wider academic research and recent contact with Lipotec, a global leader in Skin and Sun Care, this MSCA-IF-EF-SE application proposes to develop a novel sunscreen product which will deliver effective, safe and inexpensive broad-spectrum photoprotection. This project is aimed particularly at providing the global sunscreen industry with an alternative ultraviolet-A (UVA) filter: the UVA filter currently leading the market, avobenzone, quickly degrades upon absorption of UV radiation thus posing a significant risk to human health. The few currently available alternatives to avobenzone are too costly, resulting in unaffordable photoprotective products to consumers, which may have implications in skin cancer incidence. To develop this innovative, high-demand UVA-focused sunscreen product, the applicant will combine the sunscreen molecules she studied during her doctoral degree with the state-of-the-art cosmetic delivery system technology developed by Lipotec. The development of this product at Lipotec (Barcelona) will further the European scientific and technical leadership, as well as boosting the European Sun Care market and addressing the Horizon 2020 societal challenges regarding health and wellbeing.

Mots clés : sunscreens, photoprotection, microencapsulations, microemulsions, materials science, formulations, photophysics

Participants :
- Lipotec sa (Espagne) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 172932.48 €
Projet PLISUS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Drought and salt stresses constitutes key factors influencing plant growth, development and crop productivity. A key aspect of the drought and salt stress processes is the biosynthesis and delivery mechanisms of the newly synthesized lipid species towards the appropriate subcellular membranes. Previous studies in Prof Botella´s lab (supervisor) have demonstrated that Arabidopsis SYT1 (Synaptotagmin 1) is an ER-PM (endoplasmic reticulum – plasma membrane) tether component essential for proper Ca2+-dependent stress tolerance. Recently, his group has reported a tethering complex SYT1/SYT5/CLB1 (Ca dependent lipid binding protein 1) which responds to environmental stresses. The research objective of this proposal is to determine the role of SYT1/SYT5/CLB1 complex has on lipid homeostasis related to drought and salt stresses at the cellular level, using a combination of mutant analysis, cellular biology, lipidomics and biochemical approaches. According to FAO (Food and Agriculture Organization of United Nations), the findings in this project will have potential practical applications since water scarcity and high salinity are two major factors limiting the geographical locations suitable for growing crop and horticultural plants and periodically account for significant losses in plant productivity. The researcher has wide experience in Plant Lipids. In recent years, he has successfully worked in two of the world´s leading groups for plant lipids research. The host research group is one of the world-leading groups in plant responses to abiotic stress research. This inter-disciplinary European Fellowship will exploit the complementary competencies and technologies available at the beneficiary to extend the competence of the applicant, particularly in protein-interaction techniques and management skills. This prestigious fellowship will definitely contribute to his career prospects, obtaining future positions and developing new research lines as an independent researcher.

Mots clés : membrane contact sites

Participants :
- Universidad de Málaga (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €