Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SAFETYFANS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

"We synthesized a nanoform of novel functions! But, is it safe? Is it sustainable?" The Supervisor’s team in ISTEC-CNR (Host) synthesizes in their laboratory facilities new nanoforms (NF) with enhanced functionality. Their lab is a globally reputable center that over the years have established infrastructure and knowledge in developing novel nanoformulations. Everchanging, interactive, NF have a fate hard to track and policy makers, with precaution, limited NF use. However, valuable functionalities led to European initiatives to adopt the safety and sustainability by design (SSbD) concept, that ensures safety intervening at the design stage, avoiding later use uncertainties. But beyond concept, roadmaps are yet to be drawn and practices to be tried. The questions above are now addressed to the Researcher, who, during her PhD, predicted the toxicity of NF based on their physicochemical characteristics using Machine Learning (ML). The team will realize a central aspect of the SSbD concept: the design, development and validation of a framework that predicts safety, sustainability, and functionality at the synthesis stage of NF, based on previous knowledge, using ML. This framework allows in-silico testing impact on SSbD of changes in NF features without conducting the actual resource-consuming experiments. The endeavor is rooted on information digitization built on exploiting the Host’s industry and academia network and using its laboratory infrastructure to deploy real cases. The project unlocks NF applicability potential, proposes a pragmatic methodology on SSbD implementation and increases public confidence towards nanotechnology and ML. Multidisciplinarity and the Host’s extroversion will distinguish the Researcher in the growing market of scientific integrators as employees and consultants. The acquired experience is also valuable to policy institutions, aligning with the EU Green Deal position on SSbD, and the merging of disciplines in a data-connected world.


Participants :
- Conseil national de la recherche (Italie) — Coordinator, beneficiary, Recherche, subvention : 172750.08 €
Projet MitoDNASen (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

In response to various stresses such as DNA damage, telomere erosion, or oncogene activation, human cells can enter senescence. This process is characterized by irreversible proliferative arrest, deep transcriptional reprogramming, and expression of a collection of inflammatory factors termed the SASP (senescence-associated secretory phenotype). As it limits the proliferation of cells potentially bearing neoplastic potential, the triggering of cellular senescence is an essential tumor suppressing mechanism. However, the persistence and accumulation of senescent cells in aging and pathological contexts can have deleterious effects, particularly due to the SASP. It is thus fundamental to understand the basic physiology of senescent cells to develop so-called senomorphic drugs that modulate SASP expression. Changes in mitochondrial physiology elicited during cellular senescence onset strongly suggest that the maintenance and integrity of their mitochondrial DNA (mtDNA) may be altered. For instance, cytosolic leakage of mtDNA has been shown to take place in senescent cells and participate in SASP expression via immune pathways activation, but the contribution of mtDNA metabolism and replication in SASP expression has not yet been explored. My preliminary results show that mtDNA copy number increases continuously during senescence progression, accompanied by recomposing of the mitochondrial replisome. I also showed that this increase in mtDNA copy number promotes SASP expression. In the present project, I will characterize in details the alterations in mtDNA maintenance and integrity during senescence; profile the evolution of mitochondrial replisome composition; and characterize how the previous regulate SASP expression. The perspective of this project is to identify new senomorphic targets for controlling SASP expression and hereby alleviate the adverse effects of senescent cells in pathological contexts.

Mots clés : cellular senescence sasp dna maintenance mitochondrial dna mtdna mtdna deletions mitochondrial replisome stalling bioid

Participants :
- Université d'Umeå (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet GEOHARWeights (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

Our research focuses on the study of geometric and analytical aspects of various classes of weight functions that are ubiquitous in harmonic analysis. The main goals of this project are to substantially improve some of the well-known fundamental norm inequalities for Muckenhoupt weights (the Reverse Hölder Inequality) and BMO functions (the John-Nirenberg estimate), to continue developing the theory of Békollé-Bonami weights in all dimensions, and to describe the geometry of the extension domains for both classes of weights. Our methods combine classical tools in harmonic and geometric analysis with more sophisticated probabilistic techniques that have been employed in the theory of Calderón-Zygmund operators in the setting of non-doubling measures, and in sharp maximal inequalities.  The proposal is based at the Department of Mathematical Sciences (IMF), NTNU, Trondheim, Norway, with Karl-Mikael Perfekt as the supervisor of the fellowship. In addition to the research outcomes, the plan include lecturing and supervising activities, dissemination of the results in conferences, and participation in outreach activities organized by the NTNU. The research will be carried out within the research group "Fourier Analysis and Multiplicative Analysis", at the same department, whose Principal Investigator is Kristian Seip.

Mots clés : weights, functions of bounded mean oscillation, extension domains, reverse h lder inequality, maximal functions

Participants :
- Université norvégienne de sciences et de technologie (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 210911.04 €
Projet SMART-CAD (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

In Europe, out of all types of cardiovascular diseases, coronary artery disease (CAD) is the most common cause of death (more than 40%). The leading cause of CAD is a blockage in the coronary artery due to plaque deposition. Balloon angioplasty and stenting are the two solutions used to treat CAD patients. However, in both treatments, restenosis (plaque re-deposition) occurs after a few months/years, and the only solution is to repeat the treatment to reopen the blocked artery. In the past, the scientific community has proposed many ways to monitor ISR; still, no research has suggested a feasibility study or stent-based treatment along with sensing and continuous monitoring. Motivated by the urgent need for new technological advancements to reduce the morbidity and mortality related to CAD (coronary artery disease), the proposed SMART-CAD project set out to develop a novel stent-based sensor for continuous sensing, monitoring and early treatment of the ISR (In-stent Restenosis). Here, a stent-based microwave sensor will be designed and implemented on the stent’s body to sense the development of the ISR, an RFID technology will assist in continuous monitoring of coronary artery health, and a microwave ablation will treat the plaque if ISR develops in the coronary artery. This will also help to boost the sustainable development goal target 3.4 (To reduce premature and preventable deaths in Europe due to cardiovascular diseases by 2030). The interdisciplinary nature of this project is strong, involving radiofrequency and microwave engineering, biomedical engineering, and biology. The results of this project will be helpful to the scientific community and medical device industry. This project will also strengthen the researcher’s academic profile and allow her to establish her own research group.

Mots clés : antenna sensor, microwave ablation, radio frequency identification rfid , biotelemetry, coronary artery disease cad , coronary stents, in stent restenosis isr

Participants :
- Université de Tampere (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 242116.8 €
Projet TOGETHER (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Complex nonlinear optical processes have been increasingly used for the smart photonic system to meet demands of advanced light source development for numerous applications. Current flagship techniques are still restricted, lacking flexibility of the light excitation in terms of controlled spatio-temporal properties. For instance, available laser sources have only a few degrees of freedom for versatile pulse shaping and tunable wavelength emission due to narrow bandwidth of a laser gain medium. Conversely, a wide range of applications benefits from broadband light sources with on-demand characteristics in the spectral, temporal, and spatial domains. However, available broadband sources are restricted by low output power density and limited reconfigurability. Therefore, versatile, efficient, and practical light sources are necessary to motivate development of paramount applications including microscopy and metrology techniques. In this context, the TOGETHER project aims to develop an on-demand structured broadband high-power light source relying on the advantages of complex nonlinear dynamics in multimode fibers along with machine learning approaches to efficiently harness such multidimensional complexity. In particular, rich landscapes of nonlinear dynamics in multimode fibers will be leveraged for "on-the-fly" control of nonlinear propagation. In parallel, machine learning based on artificial neural networks will be employed to speed-up typically time-consuming simulations and optimize the process of supercontinuum generation in multimode fibers. Specifically, we aim to optimize broadband sources in terms of power spectral intensity and spatial shapes. The developed sources will be used to enhance the selectivity and signal of multiphoton microscopy via near-infrared excitation, while the extension of supercontinuum generation into the mid-infrared range will also be investigated via non-silica multimode fibers towards applications in molecular spectroscopy.

Mots clés : optical fiber, multimode fiber, supercontinuum generation, machine learning, artificial neural network, multiphoton microscopy, nonlinear optics

Participants :
- Université de Tampere (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet UAM Adulthood (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The overall objective of the proposed research is to better understand the perspectives of former unaccompanied minor youth in Finland regarding their transition to adulthood. An unaccompanied minor is a person (under 18) who has sought asylum without a parent or guardian. This study utilises a qualitative single-site case design underpinned by a voice-centred relational methodology (VCRM) approach that champions the voices of participants. Participants will be approximately 20 young refugees who were once unaccompanied asylum-seeking minors. There are two research objectives linked to the action of this research. Research Objective 1 (RO1) is to better understand the transition to adulthood of former unaccompanied minor youth in Finland. The participants of this study sought asylum as unaccompanied minors but are now young adults – as such, are now technically former unaccompanied minors. RO1 will address the following research questions: ‘How do former unaccompanied minor youth in Finland conceptualise the transition to adulthood?’; ‘What do former unaccompanied minor youth in Finland identify as barriers and supports to the transition to adulthood?’ Research Objective 2 (RO2) is to innovate new ways of co-constructing knowledge and art with participants, addressing the following research question: ‘How does the collaborative creation of knowledge through a participatory arts-based method amplify the voices of former unaccompanied minor youth in Finland?’ The findings of this study will have the capacity to influence the informing of needs-based policies and supports to aid in a smooth transition to adulthood for these youth, as well as advancing the state-of-the-art of our current knowledge on the transition to adulthood.

Mots clés : transition to adulthood unaccompanied minors youth finland voice centred relational methodology vcrm pronoun poems arts based methods participatory paradigm

Participants :
- Université de Tampere (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet AffordBoneS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Less than half of the global population is covered by essential healthcare services and the aim of the postdoctoral fellowship project AffordBoneS is to obtain personalized and affordable scaffolds for bone augmentation procedures. Dr. Antonia Ressler (applicant) will study scaffolds obtained by using 3D-printable calcium phosphate multi-substituted with ions (strontium, magnesium, and zinc) crucial for efficient bone regeneration. Stereolithography, as an additive manufacturing technique, is going to be used for printing precise, highly porous, scaffolds based on multi-substituted calcium phosphates for bone augmentation procedures in collaboration with the company Lithoz. After the detailed analysis of physicochemical properties of printed scaffolds, in vitro and in vivo biological properties will be obtained to determine the scaffold's osteogenic properties and the influence of substituted ions on bone regeneration by using stem cells from female and male donors and female and male rats, respectively. Further, company Planmeca will provide patient real cases and the needed technologies for obtaining a demonstration of a personalized scaffold, customized to the patient complex jaw bone defect. The project will be carried out at the Faculty of Engineering and Natural Sciences and the Faculty of Medicine and Health Technology of Tampere University, under the supervision of Prof. Erkki Levanen and co-supervision of Prof. Susanna Miettinen. AffordBoneS project requires a high level of interdisciplinary work and the project is planned bearing in the mind that the improvement in the field of bone regeneration relies on bringing together experts from different fields, who are nowadays distant from each other, such as material engineers, biologists, clinicians, surgeons, and related companies.

Mots clés : additive manufacturing, bone regeneration, calcium phosphates, computer aided design, in vitro, ion substitution, osteogenesis, scaffold, stereolithography, stem cells

Participants :
- Université de Tampere (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet PROPITIOUS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Neurodegenerative disorders are the leading cause of physical and cognitive disability, currently affecting ~15% population worldwide with estimated global cost of healthcare accosiated with them expected to at least double in the next 20 years. Five most common neurodegenerative diseases, including ALS and FTD, are linked to formation of protein deposits in patient tissues and are currently without treatment options that would prevent or alter the disease progression. ALS and FTD pathology is characterised by accumulation and formation of insoluble protein deposits formed by proteins, like TDP-43, FUS and DAXX. These proteins undergo liquid-liquid phase transition (LLPS) in cells forming non-membrane bound organelles, which are important in RNA processing and stress responses of cells but their dysregulation acts a precursor to protein fibrillation. In this project we will, therefore, combine traditional biophysical approaches with modern molecular dynamics simulations and solution state nuclear magnetic resonance to discern this complex behaviour leading to LLPS, and gain molecular insight into its onset. Major outcomes of the project are (1) Develop the necessary simulation tools by reparametrizing currently available force fields using experimental data; (2) Apply the simulation tool and analytical methods to interactions between oligonucleotides and ions with proteins and compare results to experimental data; (3) Map phases and coacervation of DAXX in the presence of nucleotides and ions; (4) identify residues crucial for fibrillation and determine their role in cellular LLPS; (5) Apply high-throughput virtual screening to design proteins aggregation breaking ligands with therapeutic potential Outcomes of this project will importantly enhance our understanding at a mechanistic level, the role of these factors in promoting LLPS in cell biology.

Mots clés : liquid liquid phase separation, protein fibrillation, force field, molecular dynamics, nuclear magnetic resonance, 

Participants :
- Université de Maribor (Slovénie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171399.36 €
Projet CoeusCy7 (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

An unparalleled advantage of light as a control stimulus, such as tunability, high spatial and temporal precision, and orthogonality towards biochemical systems, is relatively well established. However, the application of light for phototherapy in living organisms is limited by the intrinsic properties of biological tissues, allowing for significant penetration depth only in the 650 – 900 nm range. This restriction calls for a careful design of the chromophore intended for phototherapy. Heptamethine cyanine dyes are well-suited to meet the wavelength requirements essential for modern bioimaging techniques and chemistry. The biocompatibility, photochemical, and photophysical parameters of these dyes can be adjusted by varying substituents at different positions along the heptamethine chain. The CoeusCy7 project aims to synthesize cyanine dyes with aryl groups fused in the various positions of the heptamethine chain and novel types of chain substitution. A notable feature of these novel dyes is the Z configuration of the C=C bond imposed by the aromatic ring. The objective is to investigate these cyanine dyes in terms of their photophysical and photochemical properties, focusing on absorption characteristics, chemical stability, and photostability. Novel cyanine dyes are expected to exhibit bathochromic shifts in their absorption and emission spectra and to modulate other photophysical properties, such as quantum yields of accompanied chemical processes, intersystem crossing efficiency, and affinity for or production of singlet oxygen. These novel cyanine dyes would be a valuable addition to the current repertoire, expanding the scope of their photophysical, (photo)chemical, and biological applications. Moreover, the CoeusCy7 project will contribute to an advanced mechanistic understanding of the Zincke reaction used for their synthesis and will provide deeper insights into their structure and photophysical/photochemical properties.

Mots clés : cyanine dyes, photochemistry, organic synthesis, fluorescent tags, photoactivatable compounds

Participants :
- Université Masaryk (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 150438.72 €
Projet NOMEANSNO (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Rape is a crisis affecting millions globally. Yet, there is a persistent under-acknowledgement of rape, contributing to victim blaming and the normalisation of sexual violence. The rise of the manosphere—online communities promoting misogynistic ideologies—has views that were once fringe, advocating harmful notions of male entitlement and hostility towards women, become mainstream in societal discourses. Research to date cannot fully explain why rape is under-acknowledged, especially across cultural contexts. This project addresses this gap by testing a novel dual-route framework for understanding rape acknowledgement. The first route, ‘entitlement-hostility,’ examines how some individuals and groups rationalise rape through perceived male entitlement and hostility towards women. The second route, ‘false interpretation,’ explores how cognitive biases and misinterpretations of consent lead to a failure to recognise rape, even among those who believe consent is inviolable. The project's second aim is to develop and test online interventions targeting these two routes, serving as pilots for future large-scale interventions. This approach fills a crucial gap by addressing these dynamics across cultures and radicalised communities, highlighting the need for targeted, culturally sensitive strategies. The project employs a mixed-methods approach, integrating representative survey studies, qualitative analyses, and experimental online interventions in Sweden and Hungary. Results will advance theoretical understandings of rape acknowledgement and inform the development of contextualised interventions. By disseminating findings through academic publications, a toolkit for stakeholders, and public engagement activities, the project aims to drive social change, reduce rape incidents, and support victims in seeking help. The fellow will also gain vital skills in interdisciplinary research, leadership, and grant management, significantly enhancing her academic career prospects.

Mots clés : sexual violence, manosphere, gender based violence, consent

Participants :
- Université d'Örebro (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252180.0 €