Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SUBPOL (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Designing safe and sustainable batteries is of great importance for sustainable development of our modern society. Hereof, rechargeable aqueous metal-polymer batteries (RAMPBs) that combine inherently sustainable redox-active polymer (RAP) organic cathodes, safe and abundant metal anodes in water-based electrolytes are identified as promising candidates. However, to date, most of the tested RAPs are synthetic ones, and their commercial exploitation hasn’t been accomplished due to high cost/performance factor. SUBPOL proposal aims to develop sustainable RAMPBs by hybridizing cost-oriented biopolymer (Lignin; Lig) and performance-oriented synthetic RAPs (PolyCatechols; PC) into organic cathodes, and combining with appropriate metal anodes (Zn, Pb, etc), targeting their performance beyond state-of-the-art (150–600Wh/kg, ~$150/kWh). SUBPOL will follow an integrated approach of macromolecular engineering-tailor made PCs, biopolymer platform-ease of Lig modification, novel electrode fabrication methods-LbL of complimentary charged PC and Lig polyelectrolytes or polyelectrolyte complexes and device optimization. This Fellowship will provide ER strong technical, professional and transferable skills, especially with acquisition of biopolymer batteries and scale-up, which will complete his practical expertise in synthetic RAPs, their applicability in different batteries. The success of SUBPOL depends on material design, device fabrication, scale-up, and all members of this consortium: Dr. Patil-ER, supervisors, Prof. Crispin-Linköping University at host, Dr. Marcilla-IMDEA Energia (secondment), Dr. Nilsson-Ligna Energy (placement in non-academia) have already demonstrated required skills in this regard. Optimistically, SUBPOL will cover some of the priorities of HE-WP for energetic future of EU, and also its multidisciplinary aspect provide a true opportunity to reach his career goal of becoming an independent researcher in either a leading university or R&D batteries company

Mots clés : redox active polymers, organic electrode materials, organic batteries, aqueous batteries, polymer batteries, macromolecular engineering, polycatechol, lignin, bioelectrodes, cost performance, low cost

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Ligna energy ab (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Linköping (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 278409.6 €
Projet TLTL (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Towards demonstrating new electrically pumped lasers based on the emerge metal halide perovskite, it is necessary to sandwich the perovskite thin film into transport layers for the integration of electrical devices. However, it is challenging to maintain the low threshold when introducing transport layers. The appearance of perovskite/transport layer interfaces, which is absent in most optically pumped perovskite lasers, is even considered as detrimental factors to lasing actions. By carefully integrating the perovskite films into electrical device structures, though reaching very high injection current densities (> 1 kA/cm2), often fails to realize lasing actions. The next urgent milestone towards electrically pumped perovskite lasers would be realization of low threshold when incorporating transport layers. This project has the goal to reduce lasing threshold of perovskite devices through transport layer engineering, a strategy which is the key step towards realizing perovskite lasers. I will take a holistic approach, where two novel strategies are proposed independently. Two objectives will contribute to solve an important challenge on interface engineering towards electrically pumped perovskite lasers.  Objective 1: To reduce the surface recombination loss for low threshold. I will seek effective approaches to passivate perovskite films through transport layer engineering, leading to suppressed radiative and nonradiative recombination loss at perovskite boundaries.  Objective 2: To reduce recombination loss channels caused by hot carriers for low threshold. I will achieve this objective by hot carrier management via selective transport layers, aiming at suppressing hot carrier injection and facilitating hot carrier cooling.

Mots clés : transport layer engineering low threshold hot carrier management reduce recombination loss perovskite lasers

Participants :
- Université de Linköping (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
Projet LCMMCMs (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : TERMINATED

The objective of this fellowship is to train Dr Xing Ming, through a research project titled “Low-Carbon Multi-component Marine Cementitious Materials for Sustainable & Resilient Infrastructure” (LCMMCMs), to develop sustainable and resilient cementitious materials through the bottom-up approach for marine concrete infrastructures by taking advantages of the research expertise of the Fellow and the hosts. Leveraging the synergistic effects of seawater and supplementary cementitious materials (SCMs), this project will explore the complex interactions during cement hydration and the resulting structural evolution in the assistance of multi-scale ab-initio calculations and advanced in-situ and ex-situ experiments. The research will quantify these effects to optimise the compositions of LCMMCMs, improving both fresh and hardened properties and significantly enhancing their mechanical performance and durability in harsh marine environments. The project will also develop an advanced durability-coupled life-cycle assessment (LCA) model to evaluate the environmental and economic impacts of these materials, supporting the decarbonisation of the construction sector in line with the Paris Agreement and the European Green Deal. By integrating expertise across materials science, chemistry, physics, civil engineering and environmental engineering, LCMMCMs will address the longstanding challenges of sustainability and durability in marine infrastructures. The project will generate valuable scientific outputs, including new hydration models, sustainable cement formulations, and practical industry applications, all contributing to the UN Sustainable Development Goals (SDGs 6, 9, 11, 12 and 14) and the EU Mission: Restore our Ocean and Waters. The outcomes of LCMMCMs will not only support the development of resilient marine structures but also set a new benchmark for sustainable construction practices globally.

Mots clés : seawater ab initio calculations low carbon cementitious materials supplementary cementitious materials hydration microstructure durability life cycle assessment

Participants :
- Université de Beira Interior (Portugal) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Brunel University London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
- Institut national des sciences appliquées de Toulouse (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université nationale de Singapour (Singapour) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Wienerberger france (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet TE-DRIVER (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Transposable elements (TEs) make up about half of both the human and mouse genomes, playing a crucial role in genome plasticity and evolution. Most TEs have accumulated mutations that disable their transposition, but even fragmented TEs are often co-opted by the host into complex regulatory systems like promoters, enhancers and silencers, profoundly influencing gene and chromatin regulation. For example, a retrotransposon acts as a promoter to drive the expression of a specific isoform of Cdk2ap1, which is crucial for pre-implantation development. However, TEs can also trigger senescence and oncogene expression, making them a "double-edged sword" in biology. Given TEs’s dual role, the activity and regulation of TEs driving downstream transcription is extremely important for cellular homeostasis. Studies have suggested a potential role for TEs as promoters, yet evidence is fragmentary and indirect. The sufficiency of TEs in autonomously driving transcription, their interaction with genomic context, and differences between TEs in various genomic context remain largely unknown. The TE-Driver project aims to systematically and directly investigate TEs transcriptional activity and its regulation by genomic context such as DNA methylation, histone modifications and chromatin structure. TE-Driver will integrate representative TEs (MT2_Mm, L1MdTf_II, and B3A) into thousands of genomic locations in mouse embryonic stem cells (mESCs). TE integration sites will be captured via inverse PCR coupled with high-throughput sequencing, and transcriptome changes will be analyzed using Smart-seq+5’. The project will integrate these datasets with publicly available datasets on genomic context to evaluate TEs sufficiency in driving transcription within genomic contexts and elucidate differences among TEs. TE-Driver aims to advance our understanding of TE mechanisms in genome regulation and contribute to fields such as stem cell biology, developmental biology and functional genomics.

Mots clés : transposable elements transposable elements initiated transcription genomic context

Participants :
- Helmholtz Zentrum München (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 217965.12 €
Projet AI-COURTS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

While predictive and generative Artificial Intelligence (AI) technologies promise to increase efficiency and accuracy in judicial decision-making, few have holistically questioned their impact on the judiciary and justice system. Widespread adoption of AI tools to assist - or even replace - judges, poses significant challenges to the values of open justice, transparency, accountability, and equality before the law. This project aims to expand the knowledge of judicial use of AI tools and their interaction with core judicial values in the EU; provide a new framework for tackling novel emerging harms from the use of AI technologies in courts, and extend EU’s legal capacity in empirical mixed methods research. Drawing on interdisciplinary theories of judicial decision-making and critical AI studies, mixed method design and comparative EU, UK and US experiences, the project combines comparative doctrinal analysis with expert interviews with judges, lawyers, policy-makers. Project impact will be secured via academic publications, conference presentations, public communication via social and traditional media, expert workshops. Intended outcomes include a normative framework for the future development of public law in EU to govern the use of AI technologies in the courtrooms, thereby placing EU research at the forefront of a novel field of study, contributing to the EU AI strategy and UN SDGs, and promoting EU leadership in a fast-moving area of social and legal change, increasing equality, offering reduced risk and long-term economic and social benefits.

Mots clés : artificial intelligence, law, courts, judiciary, automated decision making, genai, law and technology

Participants :
- Vrije Universiteit Brussel (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 216240.0 €
Projet RRMs-lncRNA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The human METTL3/METTL14 methyltransferase complex (MTC) is responsible for the m6A methylation of a large set of RNAs, and plays a crucial role in tumorigenesis. It targets numerous long non-coding RNAs (lncRNAs), including Xist and MALAT1. To date, studies have only considered single-stranded RNA motifs, and a critical need for structural information on the complex in interaction with lncRNA has grown over the years. METTL3 and METTL14 form a heterodimer through their catalytic domains (MTDs). Additionally, each monomer comprises flexible regions that are essential to the complex activity but have been truncated because of their dynamics: the METTL3 tandem zinc-finger domains (ZFDs) and the RGG region of METTL14. Moreover, two cofactors of the MTC display a significant importance for its activity in vivo but have never been studied in interaction with lncRNA: the RNA Binding Motif protein 15 (RBM15) and the Zinc Finger CCCH-Type Containing 13 protein (ZC3H13). This project aims at understand how structured regions of lncRNAs are recognized by the functionally active MTC and its cofactors at an atomic level. For that purpose, we will measure the binding and methylation activity of both the ZFDs and RGG region to a set of RNA targets – corresponding to modified region of Xist and MALAT1 – in the context of the whole MTC with or without the cofactors. By using mutated and post-translationally modified protein, we will assess (i) the lncRNA binding cooperativity between ZFD and the MTD, (ii) the role of the RGG region methylation in lncRNA binding structure specificity, (iii) the role of the cofactors in lncRNA recognition. Finally, combining 13C methyl-TROSY experiments, segmental labeling, and paramagnetic relaxation enhancement, we will access the dynamics of the complex in interaction with the lncRNA in solution. We expect to bring high-impact structural information of the specific recognition, recruitment and modification of lncRNAs by the MTC.

Mots clés : long non coding rna, methyltransferase, nmr spectroscopy

Participants :
- Helmholtz Zentrum München (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet IDILAB (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Accelerated by the Covid-19 pandemic, rapid digitalisation has fundamentally transformed European working conditions. While its positive consequences are well recognised, digital transformation also puts a sorely needed part of the European workforce at risk of unemployment, poverty and social exclusion. IDILAB (Implications of digital transformation for migrant labour) investigates the impacts that technological progress and subsequent structural changes have on the labour market integration of migrant workers. By developing a new methodological approach, IDILAB shall provide novel evidence on migrants’ exposure to the process of digitalisation, and formulate evidence-based and innovative policy options for the EU and national governments to improve on the scope and adequacy of national and European policy directed at encouraging a fair digital transition for all, including migrants. The proposed project will contribute with new knowledge on migrants’ own perspectives on barriers and enablers for a sustainable integration in a fast-changing labour market. I, the experienced researcher (Dr Olga Gheorghiev, the Czech Republic), will work with a European centre of excellence (the Research Centre for Digitalisation of Public Services and Citizenship (CEDIC, OsloMet, Norway), and the European Trade Union Institute (ETUI, Belgium) for intersectoral knowledge transfer, career development, and European added value.

Mots clés : migrant workers, digitalisation, automation, platform work

Participants :
- Université métropolitaine d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 210911.04 €
- European Trade Union Institute (Belgique) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet PANIC (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The rise of right-wing populism in Central Europe coincides with the revival of pan-ideologies. Cases of Turanism promoted by the ruling party in Hungary and Pan-Slavism popular among right-wing activists in Slovakia pose a need to study these intellectual projects simultaneously in comparative and historical perspectives. The common feature of these competing traditions is a contradictory combination of racism and self-orientalism. Adepts of Turanism and Pan-Slavism often define themselves as belonging to a non-European race and simultaneously sympathize with typical far-right consensus on white supremacy. Why are pan-ideologies rooted in outdated pseudo-scientific theories so popular among right-wing populists of Central Europe today? To answer this question, we need to conduct a multidisciplinary study combining social anthropology and history. The proposed project aims to understand how modern adaptations of pan-ideologies differ from the original versions popular in the first half of the 20th century; and how these transformations correlate with the aims and resources (such as access to state institutions) of the ideologues. The novelty of the research project includes the suggestion to look at right-wing ideologies as phenomena embedded in the colonial and postcolonial history of the region. I propose to study Turanism and Pan-Slavism as products of contact zones, co-evolving and constantly influencing each other and affected by overlapping colonial regimes and postcolonial conditions. Following the guidelines of the Horizon Europe Programme to support social cohesion and inclusiveness, we need to conduct a focussed study of processes of polarization. The research project aims to explain how pan-ideologies attract new followers and why they are becoming popular again since the beginning of the last century.

Mots clés : right wing ideologies, hungary, slovakia, panideologies, turanism, pan slavism, self orientalism, central europe

Participants :
- Université Comenius de Bratislava (Slovaquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165059.52 €
- Finnish Heritage Agency (Finlande) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet betaPPreg (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Pregnancy is characterized by the development of maternal insulin resistance and increased hepatic glucose production to provide sufficient glucose to be used as nutrient by the developing fetus. The maternal insulin-producing beta-cells expand to counterbalance the increased glucose levels and failure of this process can lead to development of gestational diabetes, which has great health implications for both the mother and the developing fetus. Yet, our knowledge on the mechanisms behind the pregnancy-induced beta-cell expansion in humans is limited. To address this knowledge gap, in the betaPPreg project, I will use the pig model as an ideal surrogate large mammal to study the mechanisms and identify physiological drivers of pregnancy-induced beta-cell expansion. First, I will identify the extent and the different cellular mechanisms of beta-cell adaptation in the porcine pancreas over the three trimesters of gestational time (~114 days) by histological analysis. To reveal the physiological candidates of beta-cell adaptation, I will perform untargeted metabolomics coupled with proteomics analysis of serum and pancreas at sequential temporal windows during gestation. This analysis will point to the significantly changed metabolites and growth factors that can be potentially involved in beta-cell expansion. I will perform a small-scale metabolite/growth factor screen in isolated neonatal porcine islets with the most regulated factors, to causatively link the metabolites/growth factors stimulating beta-cell expansion. The most promising candidates will be then tested in isolated human islets and human-derived ductal organoids to assess their translational potential as beta-cell proliferation/differentiation inducers and human therapeutics. Overall, the proposed project will greatly advance our understanding of beta-cell adaptation during pregnancy in large mammals and provide novel therapeutic candidates for gestational diabetes treatment.

Mots clés : pancreatic beta cell expansion beta cell adaptation during pregnancy porcine pancreas

Participants :
- Helmholtz Zentrum München (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet NanoBiosens (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

NanoBiosens seeks to expand the potential of Solid-State Nanochannels (SSNs) in the field of electrochemical sensing and the study of phenomena at nanoscale. SSNs have garnered significant attention among researchers due to their promising applications. Inspired by the sophisticated transport mechanisms found in biological channels in nature, SSNs offer precise control over ion transport. Ion transport across SSNs is controlled by the geometry and physicochemical properties of the surface. Thus, highly selective and sensitive transport relies on controlling the internal chemistry and architecture of the channel. SSNs offer, in addition, new avenues to diverse device with nanofluidic and sensing applications. In this project, we endeavor the creation of SSN-based devices for biosensing while simultaneously delving into fundamental studies of building block behavior in nanoconfinement. To achieve these objectives, I will develop and test a novel dual-signal setup that combines electrochemical and iontronic measurements in SSNs. While pure electrochemical sensing faces challenges related to sensitivity, cost efficiency, and complexity, iontronic sensing enables the adjustment of ion transport properties in SSNs enhancing the performance of the sensor. Leveraging SSNs' exceptional sensitivity, we will pioneer highly sensitive enzyme-based biosensors. The innovative dual-signal sensing mechanism will harvest both the information of EC sensing and the high sensitivity of iontronic sensing. It will offer fundamental studies on building block performance within nanoscale confinement, providing invaluable insights into their behavior. Such studies are crucial for refining the precision and effectiveness of nanoscale architectures and their applications. Thus, NanoBiosens extends beyond immediate impact, seeking to push the boundaries of SSN, exploring novel methods and mechanisms for future advancements and applications.

Mots clés : nanofluidic membrane ion transport bioelectrochemistry biosensing electroactive polymers

Participants :
- GSI Helmholtz Centre for Heavy Ion Research (Allemagne) — Coordinator, beneficiary, Autres, subvention : 189687.36 €