Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SoOP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This project delves into the British influence on the US colonial rule in the Philippines (1898-1916). It studies how Britons in the archipelago and nearby Asian colonial posts swayed the local US rule to protect their interests in the islands. The project hypothesizes they shared advice on the best forms to govern the Philippines through diplomatic and commercial lobbying and the Anglophone press published in ports like Hong Kong, Rangoon, or Penang—which, as recent historiography has demonstrated, constantly flowed around Asian ports. All this information defended the establishment of a protectorate that granted Filipinos some degree of selfgovernment and the preservation of Philippine markets open for commerce. Through an analysis of the Anglophone Asian media, the archives of the people whose interests they represented, and the archives of the American colonial elites that received them, this project will elucidate how these powerful British communities in Asia conditioned another empire’s colonial rule, building upon recent developments in transimperial history. Also, this research explores the influence Britons exercised over Filipino elites. It inquires whether influential Filipino political leaders—some of whom had been exiled to British ports like Hong Kong—also considered British opinions when strategizing the best way to face the US presence in the archipelago. Moreover, it will explore how they used these nearby British media, uncensored by the US authorities, to attack the US administration in the islands, knowing that its content could arrive there. More broadly, this project proposes to understand the Southeast Asian Public spheres, like that of the Philippines and nearby ports, as connected spaces of debate, where citizens of alien nations and colonized subjects without political power could express their points of view and influence those who did have authority.

Mots clés : united states empire philippines british empire in asia colonial public spheres

Participants :
- Université Ateneo de Manila (Philippines) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 189258.6 €
- Université du Wisconsin (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet IMAT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This project will study how multilingualism and linguistic diversity are materialised in the linguistic landscape of Amdo Tibet. This region is situated in the northeast part of the Tibetan plateau and encompasses the present-day Chinese provinces of Qinghai and Gansu. The area is known for its ethnolinguistic diversity. Amdo Tibet is inhabited by several groups, such as Han Chinese (the major ethnic group in China), Tibetans, Chinese Hui (Chinese-speaking Muslims), the Muslim Turkic-speaking Salar, and Mongolic-speaking Buddhist populations. Language policies, intense urbanisation, migration, and socio-economic opportunities and imperatives have an impact on language practices and language use among ethnic groups. This project looks at these changes from the angle of language use in the linguistic landscape. This research studies ethnolinguistic diversity in space, focusing on public signs. The object of this study is the town of Rongwo, the county seat of the Rebgong (Chinese: Tongren) Tibetan autonomous county in Qinghai province (People's Republic of China), where Tibetan and Chinese are co-official languages. The town constitutes the main administrative and commercial centre of the area and features schools, administrative offices, hospitals, and different kinds of businesses such as restaurants and clothing shops). This project draws on linguistic and visual data available in public signs, ethnographically-informed data, and data on regulations of languages in space. The analysis will be based on a holistic approach that considers the informative and symbolic role of the languages involved, the language policies and ideologies at play, and language norms and language contact. The broader goal of this project is to understand the creation and management of ethnolinguistic diversity and linguistic hierarchies in urban space through languages, scripts, and other visual and semiotic means.

Mots clés : linguistic landscape amdo tibet ethnic minorities in china multilingualism language policies

Participants :
- Université libre de Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet PHYTOLIM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Aquatic ecosystems offer a wide range of ecosystem services (e.g., climate regulation, carbon sequestration, water treatment, and fisheries). In these ecosystems, Nitrogen (N) and Phosphorus (P) cycles have been modified, leading to an increase in nutrient concentration and changes in the stoichiometry of the element. In marine systems, dissolved N and P are, on average, present in an overall stoichiometry balance called the Redfield ratio (N:P=16). The skewness of stoichiometry is exacerbated by a general effort of countries to reverse eutrophication by reducing only P using water treatment plants. This management solution is leading to a global increase of the N:P in the freshwater and coastal marine systems, amplifying the likelihood of P limitation. Phytoplankton that supports the entire trophic web follows the Redfield ratio and is affected by this unbalanced ratio. Photosynthesis, diversity and physiology of the phytoplankton communities are deeply impacted by these changes, thus stressing the need for understanding this arising issue. This project aims to evaluate how reverse eutrophication (causing high N:P) affects the ecophysiology and productivity of phytoplankton. To explore this issue, nutrient experiments at an unbalanced nutrient ratio (N:P = 90) will be performed with a selection of freshwater and marine species to investigate species on the whole water continuum. An increasing diversity (single species; co-cultures; natural communities for freshwater only) gradient will be used while chemical, physiological, photosynthetic and diversity parameters will be measured. This also includes a temperature variation experiment to study the combined issue of climate change reverse and eutrophication. The information delivered by this project will be critical both for the understanding of the response of phytoplankton communities under unbalanced input and for the problem of reverse eutrophication and climate change to improve water management.

Mots clés : phytoplankton photosynthesis redfield ratio physiology biodiversity

Participants :
- Institute of Microbiology (Rép. Tchèque) — Coordinator, beneficiary, Recherche, subvention : 150438.72 €
Projet RAFAEL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Genetic interactions describe the phenotypic consequences of variations in a specific gene, whether genetically or environmentally induced, associated with other gene. Discovering synthetic genetic interactions is crucial for unraveling the complexity of metabolic pathways and cellular functions, offering deeper insights into how cells operate under stress. Traditional genetic studies in C. reinhardtii have often focused on individual gene mutations, without fully exploiting its sexual reproduction capabilities to generate double mutants. This project aims to bring a new perspective to the study of gene functions in C. reinhardtii by identifying synthetic genetic interactions among nutrient metabolism genes. Through an innovative interdisciplinary approach involving the use of available single mutant strains from Chlamydomonas Library Project (CLiP) collection, established genetic tools, and the generation of haploid double mutants via crossing, this project seeks to uncover complex interactions between metabolic pathways. By serving as a foundation for future large-scale synthetic interaction studies, this project goes beyond current methodologies in studying genetic functions in C. reinhardtii, impacting the research field of metabolic regulation in photosynthetic organisms. The RAFAEL project will contribute significantly to the fellow’s professional development, equipping him with expertise in algal genetics and expanding his interdisciplinary research scope.

Mots clés : chlamydomonas reinhardtii synthetic lethality synthetic sickness genetic interactions epistasis metabolism tor1 pathway

Participants :
- Institute of Microbiology (Rép. Tchèque) — Coordinator, beneficiary, Recherche, subvention : 207758.16 €
Projet GSQNET (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

There is a concerted worldwide effort to develop near-term networked quantum technologies (NQTs) to enable improved performances in imaging, sensing, computing, and communications. Recent landmark results from China’s quantum satellite Micius have demonstrated key milestones to increase the span of NQTs. A succession of international initiatives has also been launched to develop quantum networking infrastructure, such as the European Quantum Communication Infrastructure initiative. However, developing quantum networks (QNs) still has to overcome open challenges in feasibility, scalability, and maturity. This research project aims to directly address these open challenges. I will improve security analyses and develop two novel quantum key distribution protocols with improved loss tolerance and enhanced integration between terrestrial and satellite networks. This will enable longer-range quantum communications than existing methods. Numerical simulations and experimental demonstrations will be performed to validate this advantage. I will then develop an open-source numerical framework, based on a conceptually simple bi-graph, to inform on QN topologies that optimise entanglement distribution rates. This framework goes beyond specific network topologies considered in existing research and can be applied to any communication protocol. As a forward-looking application, I will explore the performance of distributed quantum computing. By developing insights into the optimal design of QNs that enhance the fidelity of non-local quantum gates, this work would help identify parameter regimes for quantum devices to support the operation of large-scale quantum computing. I will present a roadmap toward implementation, which may aid ongoing experimental and engineering efforts to advance NQTs. The GSQNET project is therefore a timely project that will support the development of NQTs in Europe through fundamental research and translational studies.

Mots clés : quantum internet, quantum networks, distributed quantum technologies, entanglement distribution, quantum key distribution, security analyses

Participants :
- École polytechnique de Bari (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université libre de Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202125.12 €
Projet PROTONIX (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Cancer and cardiovascular diseases are the leading causes of death in the EU, resulting in 54% of deaths in 2021. There is an urgent need for more effective therapeutics for these diseases, but drug discovery is slow, taking 16 to 20 years from target identification to drug approval.  To accelerate drug discovery, pharmaceutical companies use computational tools. Among the most successful are physical molecular simulations, which are limited by the availability of experimental structural data. A new generation of machine learning (ML) powered structure prediction tools, such as AlphaFold, offer the potential to supply structural data suitable for physics-based modeling without the need to experimentally solve structures. However, these tools produce 3D structures missing key physical details, which are vital for accurate molecular modeling. A critical physical detail is the assignment of relevant protein protonation states, where misprediction results in large errors in drug binding affinity predictions, slowing down drug discovery. PROTONIX will bridge this gap between physical molecular simulations and ML structure prediction tools to improve the speed and accuracy of computational drug discovery, by adding protonation details to structure predictions. I will focus on the human kinase superfamily, the main therapeutic target class for cancer and cardiovascular diseases. PROTONIX will contain two open-source ML models. First, PROTONFOLD will use a diffusion model to predict relevant protonation states with their corresponding proton positions from ML protein structure predictions, generating simulation-ready files. Second, PROTONCON will use a flow-matching model to integrate protonation state prediction with multiconformer protein structure generation, providing insights into the coupling between protonation states and protein conformations. PROTONIX will point the way for future AlphaFold-like models to produce structures immediately useful for drug discovery.

Mots clés : protonation state effects, kinases, protein structure prediction, computational drug design, generative modeling, diffusion models, protein conformer generation, constant ph molecular dynamics

Participants :
- Memorial Sloan-Kettering Cancer Center (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université libre de Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202125.12 €
Projet Aortic Biomechanics (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

This proposal aims to investigate the biomechanical mechanisms driving adverse aortic remodeling in patients with genetically triggered thoracic aortic aneurysms (TAA) following prosthetic graft surgery. The study seeks to identify critical features of both native aortic tissue and prosthetic grafts that contribute to the increased risk of distal aortic complications, such as dissection and aneurysm.  These objectives will be achieved by:  1. Advanced imaging and computational modeling: We will employ state-of-the-art cardiac magnetic resonance imaging (CMR) and 4D flow MRI to gather detailed pre- and post-operative data. This data will inform fluid-structure interaction (FSI) models to simulate the complex biomechanical interactions between grafts and the native aorta, providing insights that extend beyond traditional approaches.  2. Biomechanical and genetic integration: By analyzing the stiffness and wall shear stress (WSS) of the aorta before and after grafting, and correlating these changes with clinical outcomes, the study bridges the gap between genetic predispositions and biomechanical responses. This approach will also explore the role of hemodynamic forces in driving the progression of TAA, helping to identify patients at higher risk for adverse outcomes.  3. Tailored graft design: The proposal’s innovative approach includes the development of grafts with compliance tailored to individual patient characteristics. These tailored grafts, designed using FSI simulations, have the potential to reduce the risk of adverse remodeling, setting this study apart from others that use standard graft materials.  This proposal advances personalized medicine by integrating genetic and biomechanical insights to enhance patient-specific treatment of thoracic aortic aneurysms. It aligns with MSCA’s goals by fostering interdisciplinary collaboration, driving innovation in healthcare, and translating research into tangible societal benefits.

Mots clés : investigating aortic biomechanics in genetically triggered thoracic aneurysms, focusing on graft induced remodeling, fluid structure interaction, and computational modeling for improved patient care

Participants :
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209483.28 €
- Université Cornell (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Hilbert5th vs models (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

The main goal of the project is to apply advanced techniques from the model theory (a branch of mathematical logic) to the class of locally compact groups arising from the solution of Hilbert's 5th problem (so at the end, to the class of Lie groups), to answer the following question: how much geometry can model theory recognize? There does not exist a general (first-order) model-theoretic description of the locally compact groups, thus our first goal will be to develop such a description. Then, we will study how notions from these two corners of mathematics, i.e. model theory and locally compact groups, correspond to each other. For example, we will try to enrich the classification of locally compact and Lie groups by translating the dividing lines from the model-theoretic stability hierarchy. In the next stage, machinery from the so called geometric (neo)stability theory will be deployed in a tame class of locally compact groups, for example in the class of locally compact groups being projective limits of Lie groups and not having small subgroups (so in the groups from the solution of Hilbert's 5th problem). In this spirit, one could consider the definable homogeneous space coming from the Group Configuration Theorem, which is a part of the aforementioned machinery, and try to relate it to the unsolved Hilbert-Smith conjecture - this will be one of our milestones.  In short, we aim to find connections between model-theoretic theorems of geometric nature and classical theorems on the Lie groups, so theorems which depend on the geometry of Lie groups. After understanding these connections, we want to transport techniques from the model theory into the locally compact and Lie groups and vice versa.

Mots clés : model theory, geometric stability theory, locally compact groups, hilbert s 5th problem, lie groups

Participants :
- Université technologique de Dresde (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
- Université de Münster (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet HUGASEA (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

One of the major problems archaeologists have yet to address systematically is the development of watercraft and long-distance seafaring, which is critical for understanding earlier coastal and insular colonization and the emergence of social complexity among small-scale societies. The HUGASEA project is designed to address the determining factors in organizational and seafaring strategies of aquatic Hunter-Fisher-Gatherers (HFG) on the Northwest Coast of North America and the Fuego-Patagonia coast of South America. The project is based in an innovative and interdisciplinary approach: integrating Archaeology, Ethnohistory, Ecology, Computational modelling and Artificial Intelligence. The project is inherently comparative, as the two regions and their respective internal variation offer the opportunity to test past interaction among three variables: watercraft technology, environment and social organization (mobility, gender, status, cultural diversity). Ecological, archaeological and ethnohistorical data will be collected and modelled with GIS-based methods. Then, Agent-based models (ABM) will be created, validated by Sensitivity Analysis and Machine Learning (Bayesian Belief Networks) against empirical data, and finally used to geosimulate seafaring HFG in aquatic environments, test hypothesis and predict spatial patterns. The project will reach expert and non-expert audiences, including Indigenous peoples and young audiences, through a range of dissemination, communication and outreach activities. The researcher will develop the project on the US Northwest Coast, where he will expand his experience, research competencies and international networks. All the new knowledge and skills will be transferred back to the European Host during the incoming phase. Thus, the project will be very productive for both the researcher and the hosts, enhancing the development of his career as an independent researcher.

Mots clés : watercraft, seafaring, coastal archaeology, gis, spatial prediction, agent based modelling, machine learning, sensitivity analysis, hunter gatherers, northwest coast of north america, fuego patagonia

Participants :
- Université autonome de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 261380.64 €
- Washington State University (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet OP-FISSION (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

Strong light-matter coupling (SC) is increasingly proposed as a powerful tool for post-synthetic control of the optoelectronic properties of organic materials. This technology aims to exploit the easily tuneable polariton states arising from the SC between confined light fields and excitons in organic materials to rewrite molecular energy landscapes and redirect physical pathways. Singlet fission (SF) is a promising technology for improving the efficiency of photovoltaic solar cells beyond their theoretical limit. The SF process consists of the splitting of a singlet excited state into two entangled triplet-triplet states that later become two independent triplets, yielding up to two excited states per absorbed photon –hence, more efficient solar cells. Despite its great potential, SF has been observed only in a limited number of organic compounds and in many cases with a low efficiency, being the synthesis of new derivatives a huge challenge. Recently, some theoretical studies proposed SC as a post-synthesis solution to enhance the SF performance of inefficient materials, by controlling their energy landscape. However, the growing difficulty in reproducing key results in the field of Organic Polaritonics (OP) suggests a poor understanding of the involved phenomena. The major research ambition of this MSCA proposal is to understand the working principles in the OP field and demonstrate that SC can be exploited to enhance the SF efficiency. The implementation of this MSCA proposal will provide a deep knowledge of SC at the molecular scale and how to control it at the macroscale within polaritonic devices, realizing the post-synthetic control of the molecular properties. This achievement will lead to important breakthroughs in Materials Science and Photonics, setting the basis for the OP field. Besides, the proposed research and training activities will expand my experience, research expertise and networks, providing a boost to my career as an independent researcher.

Mots clés : organic polaritonics, singlet fission, ultrafast spectroscopy, dimers, polaritonics, strong coupling, microcavity

Participants :
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €
- Université Cornell (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €