Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ProMetNeu (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Bone is one of the most common organs for solid tumour metastasis. 75% of patients with late-stage breast cancer develop recurrence in bone. Current treatments are palliative, leaving this condition incurable, with an unmet need to identify new therapies. Inflammation is an important player in cancer. My pilot data show that depletion of a specific immune cell type, neutrophils, impairs bone metastasis in vivo, suggesting that neutrophils have tumour-supporting functions. However, the role of neutrophils in the metastatic bone niche remains largely unexplored, it is unknown whether they contribute to the seeding or the expansion phase of bone metastasis and if tumour cells regulate neutrophil plasticity, therefore skewing the balance towards pro-tumourigenic neutrophil subsets. I hypothesise that neutrophils acquire pro-tumourigenic phenotypes when in close proximity to cancer cells and support metastatic progression by regulating the tumour niche. By using a liposoluble fluorescent protein expressed by cancer cells, neighbouring neutrophils will be characterised: Neutrophil subsets will be identified by spectral cytometry, their transcriptomic signature analysed using RNA sequencing and their pro-tumourigenic role functionally assessed in vitro and in vivo. By employing a combination of MALDI-MSI and multiplex antibody-based imaging, neutrophil-cancer cell interactome will be established in order to identify candidate molecular mechanisms regulating neutrophil pro-tumourigenic functions. By using in vivo models of neutrophil extracellular traps (NETs) blockade, neutropenia, neutrophilia and enhanced neutrophil retention in the bone marrow, neutrophil candidate mechanisms shaping the metastatic niche will be determined. Dissecting the molecular mechanisms regulating pro-tumourigenic neutrophil subsets is fundamental to identify novel means of inhibiting bone metastasis without affecting neutrophil critical functions in inflammation.

Mots clés : neutrophils, bone metastasis, tumour niche, breast cancer

Participants :
- Université de Münster (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet GLOGOLAB (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project 'GLObal GOvernance of LABour: an integrated approach' (GLOGOLAB) aims to investigate in a comprehensive way the emergence of different transnational regimes of regulation of work in response to the increased integration of the world economy. The project uses a MSCA Global Fellowship to leverage on my expertise on multi-level economic governance, industrial relations and labour sociology and bring it from a continental to an even more relevant global level. It will be hosted by the Department of Political and Social Sciences at Scuola Normale Superiore, under the supervision of Prof. Guglielmo Meardi, who is a leading scholar in the field of labour sociology and industrial relations, and by the ILR School at Cornell University in the US (host of outgoing phase), under the supervision of Prof. Sarosh Kuruvilla, world-renowned scholar of employment relations in global supply chains. The action has three specific research objectives First, to provide a comprehensive mapping of different forms of global governance of labour emerged with the increased transnationalisation of the world economy, building a database covering the last three decades (1990-2020) (RO1), Second, to analyse and compare the impact on workers’ rights of different global labour governance structures and the different strategies adopted by social forces vis-à-vis them, through an in-depth comparative analysis of four critical cases drawn from the database (RO2). Third, drawing from different theoretical approaches (industrial relations, multi-level governance, social movement studies), to refine an analytical approach which is able to account for the complex policy processes and outcomes taking place within global governance of labour structures (RO3). By proposing an integrated approach to the study of global governance of labour the project will therefore make a significant empirical and theoretical contribution.

Mots clés : global governance of labour, industrial relations, sociology of work, social movement studies, multi level governance, transnational opportunity structures

Participants :
- École normale supérieure de Pise (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €
- Université Cornell (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet RUSTEE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This project asks how, if we take rust with its connotations of change and corruption as a starting point, we can return to three very different clusters of phenomena, each of which has been called a Revolution - the Chemical, the French and the Industrial - to understand how texts implicated in each interact. Not only do such texts exchange metaphors which structure thought and concept; they also contribute to heated debates on the nature and substance of social groups, their separation from or grounding in the natural world, and the technologies (social and material) necessary for their continued integrity. Challenging the idea that these social and material technologies can be treated distinct from one another, this project contends that any attempt to understand the implications of each manifestation of rust must include both rust's long metaphorical heritage (which stretches back through the Medieval and Classical worlds), and the contemporary innovations in the understanding of material rust, which were so important to the Chemical Revolution. Drawing on Bruno Latour's claim that "We Have Never Been Modern" and engaging with the vibrant critical territory of New Materialisms and the nonhuman turn, I will trace the 'translations' of rust between the domains of political history, the history of science and technology, philosophy and poetics. The central question of the project is: how does rust link these domains, and what can understanding them as linked by rust reveal about such vast concepts as history, society, nature and knowledge, as they took on their modern form, through the clash of revolutionary and counterrevolutionary ideologies during the Enlightenment?

Mots clés : metaphorology enlightenment studies, environmental humanities, new materialisms

Participants :
- Université libre de Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet ION-MAN (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

With global battery demand projected to increase by 25% per year till 2030, it is urgent to overcome the limitations of commercial Li-ion batteries in terms of energy density, safety, cost and carbon footprint. Batteries based on multivalent chemistries can reach significantly higher energy densities at lower costs. In particular, magnesium has very high volumetric capacity, low reduction potential, no toxicity, it is easier to handle than lithium, and 3000-times more abundant and more geographically widespread. Therefore, rechargeable magnesium batteries (RMBs) can enable safe, low-cost, high-energy-density energy storage, contributing to the energy security and the creation of a competitive battery ecosystem within the European Union. The major barrier to RMBs is the lack of Mg-conducting electrolytes that allow reversible, charge efficient plating/stripping of metallic Mg. ION-MAN will develop a new family of high-performing electrolytes for RMBs based on polymerized ionic liquids (PILs). The rationally designed electrolyte structures combine the strengths of previously reported Mg-conducting electrolytes, to the exploration of topological effects. An integrated, multi-technique approach that uses advanced characterization tools will enable to measure physicochemical properties, and propose suitable long-range charge migration mechanisms for the electrolytes. Despite the bivalency of Mg2+ leads to strong interactions with anions and solvents, the proposed methodology will allow for accurately identifying the mobile Mg species, their interactions with other components and their reactions with both electrodes of an RMB. Thus, the compatibility with Mg metal anode and selected cathodes will be thoroughly investigated, defining requirements for device optimization, toward safe and practical RMBs.

Mots clés : mg batteries, polymerized ionic liquids, polymer electrolytes, mg metal anode

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- Université de la ville de New York (Etats-Unis) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet FILMMATTER (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Films are made out of materials, at specific moments in specific places. But while philosophy of film and film-philosophy are today as strong as ever, a certain set of anti-materialist assumptions continues operating in these fields. Philosophers of film tend to treat questions of the materiality of the medium as subordinate to representational and narrative contents. Likewise, philosophical understandings of the ethical and social significance of the filmic medium continue to focus on the contents of films rather than the nature of the medium itself. These approaches can be surprising from the materialist perspectives of avant-garde and experimental cinema. But while philosophy of film and film-philosophy have not yet incorporated the lessons of the materialist avant-garde, traditional film theory has tended to treat certain geographically and nationally specific avant-gardes as though they were geographically neutral: somehow standing in for the rest. Other filmic avant-gardes belonging to other geographic regions, even those articulating compelling and innovative material views of the medium, have gotten lost. Nevertheless, a unified, materialist philosophical view of film emerges once we pay attention to the Ibero-American avant-garde, which we can call “recurrentist materialism”. Indeed, paying greater attention to recurrentist materialism and the Ibero-American avant-garde can provide an important alternative to dominant anti-materialist and geographically natural pictures in contemporary philosophy of film and film-philosophy. This is what the researcher will undertake throughout the 24 months of the fellowship through scientific articles, the preparation of a book manuscript, teaching, the organization of a colloquium on the Philosophy of Film, and a two-part film series, which will include invitations to actually practicing filmmakers, as well as two workshops for philosophers on the technical and material properties of film.

Mots clés : philosophy of film, film philosophy, experimental cinema, avant garde cinema, ibero america, latin america, politics of indigeneity, politics of immigration, ordinary language philosophy olp

Participants :
- Université de Murcie (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet SuPERCO2 (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The exploitation of fossil fuels to sustain human activities have determined a steep increase in CO2 atmospheric concentration, thus leading to climate changes. While photovoltaic devices and wind power plants provide sustainable alternatives for energy supply, chemical commodities are still mainly produced from fossil fuels. The electrochemical reduction of carbon dioxide enables generation of chemicals from CO2, water, and renewable energy, concurring to reduce CO2 concentration and store excess renewable energy. In the SuPERCO2 project, I aim to manufacture electrochemical cells achieving high performance and stability for converting CO2 to ethanol, ethylene, and further C3+ hydrocarbons. In fact, Cu-based materials, the state-of-the-art catalysts for converting CO2 to multi-carbon molecules, suffer low performance and poor long-term stability at large electrode sizes, thus limiting the industrial uptake of the technology. Besides, the lack of effective data sharing platforms prevent parallel optimization of CO2 reduction catalysts by different stakeholders, whereas poor understanding of the many interdependent phenomena which affects the process further prevents its industrial scale up. To overcome these limitations, I will carry out three main tasks: the search for improved catalysts, the creation of an open-source database to store experimental data, and the development of a multi-scale platform to model the processes involved. Overall, SuPERCO2 will contribute in the short term to fundamental insights in the field of CO2 reduction, in the mid to long term to a fossil-free production of multi-carbon molecules within European Union. Besides, by including academic (Politecnico di Torino, École Polytechnique Fédérale de Lausanne) and industrial (Teijin Materials) stakeholders, the project will provide the researcher with an all-inclusive profile in the field of electrochemistry.

Mots clés : carbon dioxide, multi carbon products, flow cell, gas diffusion electrode, electrolyte, high throughput screening, density functional theory, multiscale modeling

Participants :
- École polytechnique fédérale de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École polytechnique de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- Teijin aramid bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet BreathS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

For many years, breath analysis has been vital for clinical diagnosis of different diseases. Conventional respiratory rate monitors, however, provide only limit portability and restricted accuracy due to uncomfortable mounting of the sensors. Meanwhile, innovative healthcare monitoring gadgets emphasizing flexible and ‘imperceptible’ sensors have emerged from the rapid evolution of organic and wearable electronics. In this research project, an ultrathin sticker-type optical detector that can be worn on the chest for breath sensing is proposed. Organic semiconductor materials will be implemented into organic light-emitting and light-sensing devices (OLEDs and OPDs), integrated on ultrathin flexible substrates, and patterned to different arrays. To enable invisible sensing and to improve sensitivity, the sensor will use near-infrared (NIR) light, which provides higher penetration through skin. Narrowband organic semiconductor devices for NIR emission and detection are particularly challenging to achieve and will hence be at the heart of the project. Complementary expertise of host and fellow in OLEDs and OPDs, respectively, will lead to two-way knowledge transfer. OLED development will be further supported by a secondment at Silesian University, where photophysics of suitable NIR emitters will be investigated. Device integration and application for breath monitoring will add interdisciplinary aspects and enable the fellow to explore fields of optoelectronics, materials research, and biomedical engineering. The outlined training in material and device characterization, along with new experience in biomedical research and tailored personal development will enable the candidate to grow and pursue an academic career. Finally, BreathS will advance both OLED and OPD research while at the same time marking a breakthrough for breath monitoring, aligning perfectly with the European Union's global strategy for advancing healthcare.


Participants :
- École polytechnique de Silésie (Pologne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université technologique de Dresde (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202125.12 €
Projet SOLACE-aDNA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

More than ever before, humans have access to new specialist knowledge involving genetics (e.g., ancestry genomics, social epigenomics). Crucial questions are at stakes as this newly accessible knowledge grants individuals with an objectifying image of their ‘identity’. Knowing the ‘real’ or potential biological endowment of oneself & others has tremendous social, political, & ethical consequences. This project extends my investigation of practices whereby genetics & the construction of identities intersect in a field little studied by SSH & STS: ancient DNA (aDNA) research. At the crossroads of archaeology, bioanthropology, & population genetics, aDNA research entered a golden age in its contribution to untold facts on past societies & the way it changes how past populations are perceived. While this field is growing rapidly, in-depth understanding of social & political consequences arising from practices & knowledge produced are crucially needed. We still lack robust ethnographic understanding of how aDNA researchers incorporate the knowledge they produce into narratives about origins, ancestry, social relationships. Meanwhile, little is known about what exactly citizens or community stakeholders (CS) do with genomic histories they receive from aDNA researchers. The main goal is to study how scientists & CS interpret the past in light of this new knowledge. This project involves two research sites: researchers producing aDNA knowledge in an unprecedented case-study located in a leading research facility in Germany & the postcolonial context of Vanuatu where knowledge produced from ancient remains raises significant issues for CS’s ancestry narratives. Studying the production & circulation of aDNA knowledge in interaction between identity & from an ethnographic perspective is not only highly original & greatly needed, but timely. This project is utterly innovative, invents new collaborations & involves fields that spans across social & natural sciences.

Mots clés : science studies socio anthropology of science genomics as a cultural object ethnography social construction of the relationship to the past specialist knowledge and lay users interdisciplinarity

Participants :
- Université Deakin (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 287700.96 €
- Université du Pacifique Sud (Fidji) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of California System (Etats-Unis) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet MicroEnv (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The crucial step for selective cleavage and formation of C-H bonds is a concerted transfer of proton (PT) and electron(s) (ET): hydrogen atom abstraction (HAA) or hydride transfer (HT). The HAA and HT processes can be employed to various chemical transformations: from activation of inert bonds to reduction of CO2. This approach, however, requires a strict control of the regioselectivity of the reaction. Notably, enzymes - catalysts developed by Nature, are characterised by high activity and selectivity. In this project, we would like to provide insight into the interplay of reaction thermodynamics and sterics given by the microenvironment of prototypical enzymatic active sites (employing HAA or HT as a key step in catalysis) and to decipher which of these effects is more important in enzymatic selectivity. The focal point of the project is the novel three component thermodynamic-based model for reactivity, developed for concerted H+/e− abstraction. The model captures the coupled nature of PT and ET by the relative magnitutes of redox potentials and acidity constants of the reactants - their values determine not only the the reaction driving force but also the two novel contributions: asynchronicity and frustration with opposing effects on the barrier for the reaction. An asynchronous process, featuring a large disparity in ET and PT components of the reaction driving force, is more efficient. In contrast, a common large size of these ET and PT components makes HAA more frustrated and hence less effective. Based on this model we would like to look into systems capable of CO2 reduction and C-H bond activation to assess to what extent their reactivity is tweaked by the local conditions given by the enzymatic microenvironment versus the “canonical” factors affecting enzymatic activity, such as sterics and specific interactions. The studies may serve as a guide for design for systems capable of effective reduction of CO2 and rational redesign of C-H activating enzymes.

Mots clés : c h bond activation formation hydride transfer hydrogen atom transfer reaction mechanisms enzymatic reactions thermodynamics

Participants :
- Czech Acad Sci J Heyrovský Inst Phys Chem (Rép. Tchèque) — Coordinator, beneficiary, Autres, subvention : 150438.72 €