Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet EpiPolyPharma (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Cancer is a multifactorial disorder involving different genetic and epigenetic alterations. Since epigenetic modifications are brought about by multiple enzymes working synergistically, multitargeting compounds may be particularly effective to acutely interfere with aberrant processes. The simultaneous inhibition of two or more enzymes by a single molecule provides improved therapeutic efficacy compared to single-target inhibitors, along with reduced insurgence of drug resistance. Through this project, I aim at developing novel therapeutics targeting protein (de)methylation and (de)acetylation for application in cancer therapy. I will synthesise and evaluate hybrid molecules inhibiting two enzymes at the same time. I will develop two classes of compounds targeting the Lysine-specific histone demethylase 1A (LSD1) and either Protein arginine N-methyltransferase 5 (PRMT5) or Histone deacetylases 1-2 (HDAC1-2). These enzymes cooperate in different pathways that lead to cancer insurgence and progression, hence dual targeting represents a successful strategy to counteract tumour growth. To achieve the outlined aims, I will employ a multidisciplinary approach requiring the fusion of knowledge and tools from medicinal chemistry, biochemistry, biophysics, molecular and cell biology. Through the employment of cutting-edge synthetic approaches, I will prepare LSD1/PRMT5 and LSD1/HDAC1-2 inhibitors which will be assessed through multiple biochemical and biophysical assays. I will also employ native mass spectrometry to investigate their mode of action in the context of the multi-protein complexes formed by the protein targets. The most promising inhibitors will be evaluated in cellular assays to assess their anticancer properties and their effects on transcriptional regulation. This project will open innovative avenues for personalised therapies and provide additional weapons to overcome drug resistance, along with adding new knowledge on the epigenetic mechanisms of cancer.


Participants :
- Université de Rome « La Sapienza » (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183970.08 €
- Université de Pavie (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet OPTIMA (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The OPTIMA project (Organization sPecific Threat Intelligence Mining and sharing) aims to design techniques and tools for the extraction of Threat Intelligence targeted to organizations using ML algorithms, and effectively share attack records using privacy-preserving methods. The project will use technologies to protect societies from cyber-attacks and sophisticated threats prioritized in the European Council’s New Strategic Agenda. The key beneficiaries of the project are (a) security operation center-to support real time monitoring (b) incident response, threat hunting, fraud detection team-to prioritize risk (c), operational leaders- to prioritize activities of IT staff and (d) Strategic leaders such as Chief Information Security Officers - to make well-informed business decisions. This project will be executed at the University of Padua, under the supervision of Prof. Mauro Conti. The project will investigate solutions for the core questions: RQ1: How effectively can ML algorithms extract organization-specific threat artefacts to be utilized for preparing actionable Threat Intelligence? RQ2: How can organizations share threat intelligence without disclosing their private information to others? The objectives (SO) of the project are as follows: 1. SO1-To develop techniques for automatic extraction of threat intelligence using OSINT data for diverse IT industries (health care, finance, IoT, education, etc.) using deep learning approaches. 2. SO2-To create a novel automated system to derive Indicator of Compromise (IOC) based on word embedding and syntactic dependencies of words to identify unseen IOCs. Utilizing the extracted IOCs a threat index will be estimated to define the impact of threat and attack trends across individual organizations; 3. SO3-To build a system by integrating cryptographic tools and Federated learning which will enable an organization to anonymously share threat logs with different parties in a privacy-preserving manner

Mots clés : cyber security

Participants :
- Université du Sannio (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
- Université de Pavie (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ENVIMP (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This project studies the national implementation of legal judgements from courts and managerial agreements from non-compliance mechanisms on European and international environmental issues. Against the background of the increasing impact of climate change and a lack of specialised jurisdiction over environmental disputes beyond the nation state, the implementation of legal obligations is a crucial tool to protect Earth’s environment from harm. Yet, systematic insights on the national implementation of so-called ‘resolution mechanisms’, i.e., managerial agreements from non-compliance mechanisms and court judgements on supra- and international environmental issues, are lacking. This project will investigate the conditions explaining effective implementation of such agreements and judgements by adapting insights on policy implementation research and comparing processes of implementation across different types of resolution mechanisms. It will develop an innovative, theory-driven concept-structural framework based on key conditions from the implementation literature (actor preferences, institutional legitimacy, resolution mechanisms) that mirror the existing management and enforcement approaches. The framework will enable systematic comparisons across resolution mechanisms and thus account for a diversity of separate but equally valid explanations. Empirical analysis will follow a mixed methods approach that includes (1) data gathering based on public documents and expert interviews, (2) a comparative assessment via Qualitative Comparative Analysis (QCA) including case studies, and (3) in-depth process tracing of unexpected cases identified in the QCA. This approach will provide generalisable insights on how different preferences combine with varying degrees of legitimacy and resolution mechanisms to explain the national implementation of managerial agreements and court judgements on environmental issues.

Mots clés : policy implementation environmental policy environmental law judicial governance international courts enforcement non compliance mechanisms qualitative comparative analysis qca

Participants :
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
- Université de Kōbe (Japon) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SEDIPLASTIC (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

We live in the “plastic age”. Plastics are key for societal innovation and used on a daily basis. However, due to their ubiquity, persistence, inadequate management & improper waste disposal, they tend to accumulate in the environment. Besides, during their life cycle, they degrade into tiny polluting bits called microplastics (MP<5mm), considered a major environmental threat. Biodegradable plastics (BioMP) have become an alternative since they can be mineralized under certain temperature and moisture conditions. Fluvial sediments and their inherent microbial communities could potentially decompose BioMP due to their role as a nutrient recycling and its high enzymatic activity. However, how the degradation of BioMP will affect nutrient re-cycles in aquatic ecosystems, an essential ecological service, is still unknown. In addition, global change, especially, rising temperature, and hydrologic extreme events, mobilize plastics in freshwater systems and further degrading them into MPs. Thus, there is an urgent need to develop tools to assess, predict and mitigate their effects on freshwater ecosystems. SEDIPLASTIC seeks to explore and provide new knowledge on MP (non- and biodegradable) effects on freshwater sediments under global change conditions. Sediment columns with different grain size, with/without microbial communities, and microparticles (inert, MP, BioMP) will be used. Hydrological parameters, nutrients, dissolved organic carbon, bacterial biomass, viability, and functionality, and MP mobility and degradation will be analysed. Moreover, to better understand the key role of MP in freshwater sediments and how can affect ecosystems services, a predictive model will be developed using project experimental data. Project outcomes will impact beyond academia providing novel tools for industry, government, and thus societal wellbeing. It will contribute to major EU research priorities and to global efforts such as the UN Sustainable Development Goals (6, 12, & 14).

Mots clés : freshwater systems, ecotoxicology, biofilms, sediments, infiltration systems

Participants :
- Université de Gérone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
- Université polytechnique de Catalogne (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet UltraMolMag (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Molecule-based magnets are crystalline materials that exhibit magnetic properties analogous to those observed in traditional permanent magnets, but they can also show unique desirable functionalities, including low density, mechanical softness and physical tunability. In particular, the use of organic radicals in combination with 3d metals has been demonstrated by the Host group of Dr. hab. Rodolphe Clérac to produce high-temperature molecular magnets. However, frameworks featuring cationic 4d and 5d metal nodes are significantly underrepresented in this field of research, despite the fact that they offer more diffused d orbitals and greater spin-orbit coupling. The combination of these characteristics with the strong magnetic coupling offered by the radical ligands should result in the creation of ultrahard magnets operating at room temperature. This would challenge the monopoly of rare-earth magnets, the production of which is dependent on the supply of precursors that must imported into the EU. Therefore, the main objective of the UltraMolMag project is to develop a suitable synthetic methodology for the preparation of metal-radical systems featuring 4d and 5d elements as cationic centers. Their incorporation into extended systems is a formidable challenge, however, they can be tamed by the chemical tuning of the coordination sphere. In this project inert metal centers will be activated by preparing precursor complexes with labile substituents. Conversely, the unwanted catalytic activity will be mitigated by binding metal ions in the form of pre-organized units. The ultimate aim is to develop porous magnets based on extended radical anions, which will for the first time enable control over magnetic hysteresis through guest adsorption at room temperature. The implementation of this project will result in the creation of a library of heavy transition metal precursors and the fellow will receive training in the characterization of target frameworks.

Mots clés : molecular magnetism

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 226420.56 €
Projet PERIL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Harmful algal blooms (HABs) pose significant threats to marine ecosystems, human health, and coastal economies worldwide. These blooms often coincide with the breeding periods of bivalves, adversely affecting their reproductive output. Bivalve aquaculture, which is crucial for food security and coastal economies, is particularly vulnerable to these effects, threatening the sustainable production of cultivated bivalve species. Despite extensive research on HAB-related toxins and their implications for food safety, the broader physiological effects on bivalve reproductive health remain poorly understood. With HABs increasing in frequency due to global changes, investigating their impacts on bivalve reproduction is essential for addressing the resulting ecological and socioeconomic challenges. The PERIL project aims to assess the impact of regularly blooming and emerging HAB species in European waters on the reproduction and early developmental stages of commercially and ecologically important bivalves. Specifically, the project will elucidate the toxicity of HABs on bivalve gametes through both direct and parental exposure. The mechanisms affected by HAB exposure during bivalve gametogenesis, embryo-larval development, and the parental transmission of traits to offspring will be thoroughly investigated. To achieve these objectives, a novel integrative approach will be employed, encompassing physiological, cellular, molecular, and epigenetic analyses. Overall, PERIL represents a pivotal step toward a comprehensive understanding of HAB phenomena on bivalve population renewal. It will generate data to support the development of a standardized bioassay, which will serve as an innovative tool for assessing the reproductive toxicity of HABs. This approach has the potential to revolutionize strategies for bivalve conservation, restoration, and aquaculture.

Mots clés : bivalve reproduction, gametes, harmful algal blooms, parental effects, toxicity mechanisms, transgenerational plasticity

Participants :
- Université de Caen Normandie (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Padoue (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 226420.56 €
Projet ENRAOR (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Water scarcity and contamination are the major challenges threatening the human health and sustainable development of our society. One of the utmost concerns comes from the imbalance of the global nitrogen cycle due to anthropogenic nitrate water contamination. High concentrations of nitrate in water bodies can cause eutrophication issues, leading to negative effects on biodiversity, fisheries, and recreational activities. Similarly, the contamination of freshwater systems by chemical compounds such as micropollutants (MPs) and per- and polyfluoroalkyl substances (PFAS) from industrial and human activities is also receiving significant public attention. These organic pollutants are believed to raise considerable toxicological concerns, even though most are present at low concentrations in the environment. Eliminating pollutants from water using electricity is becoming an attractive approach for water treatment. Meanwhile, electrochemical nitrate reduction to ammonia (NH₃) (NO₃RR) using renewable energy has gained intensive interest as a method to close the nitrogen cycle. This research project, undertaken at Institut Européen des Membranes (IEM), aims to integrate nitrate reduction to ammonia with the removal of micropollutants/PFAS from both drinking water and wastewater in a bipolar membrane electrolyser. This advanced, highly synergistic system is poised to tackle two of the most pressing global challenges—energy-efficient ammonia production and the water scarcity crisis—simultaneously. By converging the processes of nitrate reduction and micropollutant/PFAS elimination into a single operation, our proposed method not only signifies a leap towards mitigating climate change effects but also promises a substantial enhancement in water quality, addressing the urgent need for safe and accessible water.

Mots clés : nitrate reduction, ammonia electrosynthesis, water treatment, micropollutants, electro oxidation, pfas, electrochemical treatment, bipolar membrane electrolyser

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 226420.56 €
Projet KNEEUL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

More than 520 million people worldwide suffer from arthritis, with 60% being women. The knee joint is the most commonly affected, accounting for 365 million cases. Cartilage repair surgery, a promising technique, requires strict control of joint pressure during the post-surgery recovery period. The KNEEUL project, a preclinical technology initiative, aims to develop a knee joint brace that unloads pressure on knee cartilage after surgery, thereby shortening patient recovery time. This type of wearable device, offering such functionality, is unprecedented and presents two key challenges: 1. Developing strategies to effectively unload knee cartilage pressure, and 2. Achieving non-invasive real-time estimation of knee cartilage pressure. KNEEUL will be conducted with the Laboratoire d’Informatique, de Robotique et de Microélectronique de Montpellier (LIRMM) as the host institution, in collaboration with the Laboratoire de Mécanique et Génie Civil (LMGC) and the Centre Hospitalier Universitaire (CHU). The project will address these key challenges through two main approaches: 1. Developing a wearable orthosis that effectively unloads inner knee joint pressure through non-invasive distraction of the femoral from the tibial part. This includes: 1) designing the pressure unloading mechanism, 2) creating a stiffness-adjustable attachment mechanism, and 3) developing and realizing the prototype. This research integrates mechanical transmission, biomechanics, and materials science. 2. Achieving real-time, non-invasive estimation and feedback of knee cartilage pressure. This includes: 1) implementing portable measurement hardware, 2) developing a pressure estimation model using multi-sensor data fusion, and 3) integrating the prototype and validating the research approach. This research integrates biomedical knowledge, sensing technology, and intelligent algorithms.

Mots clés : wearable robotjoint cartilage pressuremechanism designnon invasive pressure sensing

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 242260.56 €
Projet MUSArGre (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project aims at giving a complete and complex study of the science of harmonics within the Islamic philosophical tradition. In centuries 9th-11th CE, harmonic science develops as one of the four mathematical sciences of the ‘Ulum Riyadiyyah (Quadrivium), as a philosophical discipline largely independent of musical practice. The discovery and the translation of the Greek harmonic sources, thanks to the mediation of Byzantine erudition, are the driving force behind the emergence of harmonic science in Islamic thought. Through a philological approach, which involves a critical examination of the six main Arabic texts that represent this phenomenon, their translation, and a textual and content comparison with the Greek sources, an overall philosophical framework of Islamic harmonics will be provided. The six pivotal Islamic sources are al-Kindī, Hunayn ibn Ishāk, the Ikhwān al-Ṣafā (‘The Brethren of Purity’), al-Fārābī, al-Khwārizmī and Avicenna. The project includes also the lemmatisation of the selected texts: through the concordance software AntConc, each text will be compared to the lemmas database, enabling linguistic analyses, and enriching the literary inquiry. The overall framework of Islamic harmonic theory aims at being broad in scope: it will encompass the distinctive features of the exposed theories, the ideological objectives, the utilization of Greek sources, and the intellectual context in which the phenomenon develops.

Mots clés : islamic philosophy, arabic literature, mathematical sciences, science of harmonics, ancient greek literature, ancient greek science, byzantine reception

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 226420.56 €
Projet SUMOST (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

"Heating and cooling are needed in almost all areas of our modern society including, industry, houses, clothing, and electronic devices. This project seeks to fundamentally change how we generate heating and cooling by developing a new class of solar thermal management materials (MOST) that capture, store, and release both solar and ambient heat. These materials are a unique combination of molecular photo-switches that capture and store solar energy, that together with phase change materials (PCMs) can contribute to thermal management. The input of MOST system is photons, and the output is heat whereas PCM can absorb heat from the environment and thus facilitate cooling. By combining the two materials into one, we can harness and upgrade two of the most abundant renewable sources of energy on the planet: ambient heat and sunlight. Additionally, we will modify the materials in radically new ways to explore if they can contribute to cooling. The outcome of the project will be an emission-free energy system that can capture, store, and release energy, without being consumed in the process, as per the European Green Deal Project."

Mots clés : molecular solar thermal most energy storage materials phase change materials plastic crystals organic photoswitching materials crystal engineering supramolecular synthons

Participants :
- Université polytechnique de Catalogne (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209914.56 €