Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet OxyQuant (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Because of their sheer size and tight coupling to the atmosphere the oceans are a pivotal climate regulator. Their interaction with climate is associated with both physical processes such as ocean circulation, which redistribute heat, freshwater, and carbon around the globe, and biogeochemical processes, which ultimately control the strength of the biological carbon pump, and by inference the storage of remineralized carbon in the ocean interior. Seawater oxygen concentrations are intimately linked to both type of processes and are thus a crucial parameter for assessing the state of the oceans today but also in the past. Despite the crucial role these processes play on climate and climate variability, they remain surprisingly poorly understood. While paleoceanography offers a unique opportunity to observe the state and behaviour of the oceans under different boundary conditions, no reliable and widely applicable method for the quantitative reconstruction of past bottom water oxygen concentrations (BWO) has yet been established. Thus, the objective of OxyQuant is to develop and calibrate an innovative proxy toolkit to reliably reconstruct past BWO. To this end, three fundamentally independent approaches for which promising preliminary observations exist will be calibrated using a range of sediments retrieved from contrasted marine environments. While the first approach associated with the sedimentary concentrations of redox-sensitive trace metals, has already attracted much interest over the past decades, the other two methods, namely the organic matter – associated iodine and the stable isotope composition of authigenic cerium (δ142Ce) archived in fossilised fish debris, are novel and have yet to be comprehensively tested. Combined with their application in two case studies on glacial – interglacial time scales, OxyQuant will provide the paleoceanographic community with the means to finally fill the gap of quantitative reconstructions of past BWO.

Mots clés : paleoceanography, oxygenation, redox sensitive metals, rare earth elements, element cycles, marine sediments

Participants :
- Université de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- GEOMAR Helmholtz Centre for Ocean Research Kiel (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 321472.8 €
Projet AAPSG (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

"Democracy in Retreat" was the 2019 title of the Freedomhouse index, which ascertained 13 consecutive years of a global decline in political rights and civil liberties from 2005 to 2018. The report foregrounds the alarming erosion of long-standing democracies and those part of "democracy's third wave", which began in the 1970s in Southern Europe, followed by countries in Latin America and East Asia and culminated in the dramatic regime breakdowns initiated by democratic reforms in Central-Eastern Europe (Soviet Union), South Asia, and sub-Saharan Africa. A period that has inspired scholars to deliberate the idea of democracy representing the "ultimate end of a country’s political development" or even the "end of history" itself. This period of democratization was initially lauded as a "linear set sequence", which would eventually encompass the globe. From the early 21st century on, however, a new generation of scholars has been describing a reverse wave of regime changes (Diamond, 2015; Lührmann & Lindberg, 2019). This "authoritarian resurgence" has evoked a scholarly debate on the causes, mechanisms, and perseverance of such "new" authoritarian regimes (Cassani & Tomini, 2019; Del Panta, 2019; Wiatr, 2019). While (university) student movements were commonly identified as prominent actors/forces of social change during the third democratization wave, my research will examine the role students play in the creation, maintenance, and innovation of (resurgent) authoritarian/autocratic regimes. They represent an alternative form of citizenship that neither fits needly into universalized social locations, such as "civil society", nor postcolonial conceptualization, such as Chatterjee's (2004) "political society". Using Bangladesh and Uganda as case studies, my research project explores how globally connected student groups are influential and understudied actors in autocratization processes and the shaping of these "new" regimes’ ideological foundations.

Mots clés : student politics autocratization authoritarianism political violence social cohesion uganda bangladesh

Participants :
- Université de Leipzig (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
- Stiftung Wissenschaft und Politik, Deutsches Institut für Internationale Politik und Sicherheit (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet WATIME (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The evolution of H. sapiens in Africa is intrinsically linked to the expansion of the Middle Stone Age (MSA). West Africa is one of the last frontiers for human evolutionary research and has long been considered to have played virtually no role in our species' biological, cognitive and behavioural evolution. Recently-excavated MSA sites across West African changed this perception, but there is still a critical need for reliable chronometric dates to establish a secure timeline for the MSA. While the Optically Stimulated Luminescence (OSL) dating applied to quartz has already provided some key chronological constraints, the method has also shown some clear limitations as it cannot chronologically cover the entire MSA time range.  WATIME project aims to explore the potential of the Electron Spin Resonance (ESR) dating, the key alternative method to date quartz. The project is built on promising results from a pilot study at Bete I-Anyama site (Ivory Coast), which not only demonstrated the potential and feasibility of using Titanium (Ti) signals to date quartz samples from West Africa, but also led to the identification of some specific methodological issues worth investigating further to ensure the reliability of the ESR dating method. WATIME will address them by developing and quantifying and measurable accurate criteria to assess the suitability of Ti ESR signal, improving spectral resolution, measurement precision and signal characterization.  Implementing a new rapid and accurate laboratory ESR dating procedure will help resolve the chronology of MSA West African sites that cannot be dated by other means. WATIME opens an innovative way to date the key changes in cultural/behavioural patterns from the archaeological record in West Africa. The results will be broadly communicated through open access and open peer reviewed article resources, and targeted public outreach activities.

Mots clés : timeline, geochronology, electron spin resonance dating, quartz, west africa, middle stone age, african middle pleistocene, african late pleistocene, human evolution, homo sapiens

Participants :
- National Research Center on Human Evolution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet WISDOM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

WISDOM analyses the socio-legal roles attributed to women in three regions of early medieval Europe: Ireland, Francia, and Lombardy from c. 500 to 800 CE. It takes an interdisciplinary approach to the legal texts written in Latin and Old Irish, by combining critical historical analysis, comparative legal history, anthropology and gender studies. This allows me to mediate between law and social norm in a time where those boundaries are more fluent than nowadays. Its primary objective is to unravel the underlying social values and role attributions governing women's legal agency. This will be done first on an individual basis due to the varying social, linguistic and historical background of each region, and subsequently with a comparative approach drawing out cross-cultural tenets that bind together women's lives and legal thinking in the early middle ages. WISDOM addresses a vital area of research from an innovative vantage-point of sources and methodological approaches. As a result, it will provide a novel comparative framework to specialists in legal history, gender history and early medieval studies. This is timely and relevant, because it links to the evolution of legal thinking and generates new knowledge and interdisciplinary insights into women's experiences, unearthing forgotten narratives from the middle ages that offer lessons for the present.

Mots clés : early irish law, lombard law, frankish law, early medieval legal history, comparative legal history, ritual and symbolism

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
- Université d'Helsinki (Finlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet GlocalFem (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The fourth wave of feminism propelled by global trends and catalyzed by the #metoo movement in the early 2010s has ushered in new dimensions of online activism, mass media representation, and intersectionality. Scholarship has often highlighted the transnational nature of the feminist movement. However, this project aims to explore how 4th wave global feminism intersects with regional nuances, with a focus on the specific case of Catalonia. “Embodying Glocal Feminism: A New Feminist Cultural Movement in Catalonia (2017-2023)” (GlocalFem) examines the intersection of cyberfeminism and globalization with local factors such as the historically minoritized Catalan language, the stateless national Catalan identity, and feminist authors of the Catalan-Moroccan diaspora, as well as material urban changes in the city of Barcelona. The study emphasizes the necessity of an interdisciplinary model of analysis and proposes a new lens, "glocal feminism," to examine how the global 4th wave feminist movement translates locally. By utilizing an interdisciplinary methodology, GlocalFem examines a cultural and artistic movement that started in 2017 among millennial and Gen Z female cultural creators. These women navigate and challenge conventional boundaries through their knowledge production, blurring the line between popular/academic knowledge production, online/offline activism, and global feminist identity/Catalan national identity. Through the documentation and analysis of podcasts, TV series, films, social media accounts, and new spaces in the city of Barcelona, together with interviews with feminist content creators, this project seeks to understand how this new wave is shaping local realities in Catalonia. The study's findings could pave the way for similar investigations in peripheral regions of Europe, propelling feminist discourse within local contexts and minority languages and reconfiguring the landscape of knowledge production.

Mots clés : cultural studies, catalan studies, 4th wave feminism, cultural movements, popular culture

Participants :
- Université Pompeu Fabra (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
- Almena cooperativa feminista (Espagne) — Partner, associated partner, Autres, subvention : 0.0 €
Projet PARTHECOM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Parkinson’s disease (PD) is a neurodegenerative disease with growing incidence. More than 10 million people worldwide are affected by this condition. In addition to decline in the patients’ quality of life, the economic burden of PD is estimated to exceed 13,9 billion EUR in EU annually. Considering this, novel and more efficient therapeutic options are needed, as current PD treatments alleviate symptoms without stopping neurodegeneration and progression of the disease. Although the etiology of PD is unclear, degeneration of dopamine (DA) neurons has been shown to result from certain genetic mutations, toxins and pathological protein aggregation among others. Importantly, recent evidence points to decrease in mRNA methylation at adenosine N6 (m6A) in PD. Data also indicate that m6A reduction may induce DA neuron apoptosis. Prof. Mart Saarma and collaborators have discovered that m6A methylation is a crucial regulator of neuronal apoptosis. They developed novel m6A methyltransferase activators and demethylase inhibitors that potently enhance mRNA m6A levels. Importantly, preliminary data show that these compounds protect DA neurons from neurotoxin-induced death in culture at nanomolar concentration. Moreover, one compound tested thus far remarkably improves motor behavior, protects and regenerates DA neurons and their axons in rat PD model more potently than “gold standard” GDNF. Considering this, the current project aims to elucidate the mechanisms how m6A regulates DA neuron survival and axonal regeneration. We will identify for the first time the mRNAs with increased/decreased methylation at adenosine N6 that regulate the life and death of DA neurons, thereby potentially opening new directions in PD research. In addition, we aim to provide completely new lead molecules for PD treatment. In conclusion, the current project aims to broaden our understanding on the mechanisms of Parkinson’s disease and provide new drug candidates for novel PD therapeutic avenues.

Mots clés : parkinson s disease, neurodegeneration, neuroregeneration, dopamine neurons, mrna methylation, n6 methyladenosine

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université d'Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet ProDiME (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

Our research project is inscribed into the domain of mathematics education (didactic of mathematics): a research domain at the interface of mathematics and social sciences. The project is based on the collaboration of three researchers: Katalin Gosztonyi as Experienced Researcher, assistant professor at the Eötvös Loránd University of Budapest; Viviane Durand-Guerrier as Principal Supervisor, emeritus professor at the University of Montpellier; and Simon Modeste as Co-Supervisor, assistant professor at the University of Montpellier. Our project is focused on the development and analysis of complex problem-networks which will then serve for the conception and implementation of problem-based teaching trajectories. We aim to develop an efficient modelling framework in order to construct, analyse and represent problem-networks and problem-based trajectories for mathematics education – both for research purposes and for supporting teachers’ work in planning their teaching processes. We focus more particularly on problem-networks and teaching trajectories in the domain of discrete mathematics: on their potential place and role in mathematics curricula; their values for conceptual learning as well as for the development of generic mathematical skills (related to problem solving, abstraction, proof etc); and their potential connections with other mathematical domains, including links between mathematics and computer science. A theoretical and epistemological work and a priori didactical analysis of examples of problem-networks will be combined with experimental research on teachers’ and students’ work with problem-networks. The theoretical background of the project combines theories of the didactics of mathematics from the French research tradition with current research on the Hungarian Guided Discovery mathematics educational tradition. Experiments will be realized in both countries.

Mots clés : didactic of mathematics, inquiry based mathematics education, discrete mathematics education, theory of didactical situations, didactical engineering, theory of conceptual fields, series of problems

Participants :
- Université de Montpellier (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet TransSocio (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Within a broader vision of technocratic socialism in Eastern Europe, expert-led socialist modernization turned to social issues beginning in the 1960s. Existing scholarship on the development of sociology in different national contexts in the region shows that the discipline was accommodated as a technical, but not critical source of social expertise both before and after 1989. Going beyond this well-researched national level, the project “Transnational sociology and concepts of social expertise in Eastern Europe, 1970s-2000s” (TransSocio) asks how socialist sociologists were embedded in transnational epistemic networks regionally, transregionally, and internationally beginning in the 1970s, and what their contribution was at the articulation of the main social issues of their time. TransSocio is an interdisciplinary intellectual history and digital humanities project, which will produce a database of sociologists involved in collaborative research beyond their national context, a corpus of machine-readable publications stemming from such involvement, and a collection of twenty oral history interviews with sociologists from throughout the region who contributed to transnational social expertise. On this basis and by combining DH methods (social network and text analysis) and intellectual history methods (contextual analysis of concepts), TransSocio will map the transnational epistemic networks and the concepts of social expertise to which Eastern European sociologists contributed, and will explore their uses up to the early 2000s. This is a history worth recovering as a counterpart to the current crisis of expertise in Eastern Europe; as a genealogy of epistemic inequalities engendered by professional and conceptual integration in Europe beyond the national level; and as a resource for strengthening social expertise, the public trust in science, and visions of transnational social solidarity at a moment of renewed crisis due to pandemic, war, and economic austerity.

Mots clés : eastern europe, state socialism, postsocialism, social expertise, transnational epistemic networks, digital humanities

Participants :
- Institut za novejso zgodovino (Slovénie) — Coordinator, beneficiary, Recherche, subvention : 155559.36 €
Projet LoCo-Effect (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The COVID-19 pandemic placed a heavy social and health burden on populations. Yet, because of social inequalities in the pandemic’s impact on fertility behaviour, babies conceived during the pandemic may be the most socially advantaged and healthiest birth cohort of the last decades. Research on this counterintuitive but realistic consequence of the pandemic – the Lockdown Cohort (LoCo)-Effect – is critical for public policy and the understanding of pandemic consequences. As individual-level register data for babies conceived and born in 2021 and later is only just becoming available, we still know little about how the pandemic changed the composition of parents and to what extent this explains changes in birth outcomes for those born during the pandemic. To address this knowledge gap, I will use individual-level register data (2010-2022) from Finland, Scotland, Austria, Spain, the United States, and Brazil and natural experimental methods to study the LoCo-effect comparatively. This strengthens the generalisability of results across different welfare regimes and pandemic experiences. First, I will study the magnitude of compositional changes in parental characteristics due to the unequal impact of the pandemic on fertility. Second, I will analyse the extent to which differences in prematurity and birth weight between the LoCo and earlier cohorts are caused by this change in parental characteristics. Third, I will estimate how the pandemic has affected intersectional social inequalities in birthweight and preterm birth. This project is innovative because it bridges disconnected debates in demography, epidemiology, and sociology to explain why, against expectations, pregnancy and birth outcomes have improved during the pandemic. As parental characteristics and birth outcomes shape health, developmental, and socioeconomic outcomes throughout life, the results of this project will influence social and public health research and policy for decades to come.

Mots clés : register based individual level data comparative research, social epidemiology health inequalities birth outcomes natural experimental methods

Participants :
- Université d'Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199694.4 €
Projet LIM-it (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The LIM domain proteins LASP1 and PDLIM4 are associated with the actin cytoskeleton, and implicated in many diseases. However, their precise molecular functions are poorly understood. Recent protein interaction studies from my host laboratory provided evidence that these two proteins associate with stress fibers (SFs), the contractile actomyosin structures of non-muscle cells. Distant homologues of LASP1 and PDLIM4 are also present in muscle sarcomeres, suggesting a potential structural role of these proteins in SFs. However, several other LIM domain proteins are involved in a wide-variety protein-protein interactions and signaling pathways, suggesting possible roles for LASP1 and PDLIM4 in signal transduction, especially in mediating mechanosensing in SFs. Indeed, previous studies proposed that LASP1 is a possible regulator of translation, whereas PDLIM4 may function as an adaptor between the cytoskeleton and kinases. The aim of my work is to elucidate the molecular functions of PDLIM4 and LASP1 using a combination of proteomics, cell biological, genetic and biochemical approaches. My specific interest is to uncover whether PDLIM4 and LASP1 are structural components of stress fibers, or if they function as mechanosensitive regulators of translation or intracellular signaling. The findings will uncover the roles of PDLIM4 and LASP1 in cytoskeleton organization, potentially providing new insights into various diseases, including cancer. Additionally, understanding the interplay between SF-mediated mechanosensing and translation may reveal new mechanisms by which cells respond to mechanical cues. Overall, this study will broaden our understanding of SF-signaling, and has potential implications for therapeutic interventions in diseases linked to SF-dysregulation.

Mots clés : actin, stress fibers, mechanosignaling, cytoskeleton, cell migration, cell adhesion, u2os

Participants :
- Université d'Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199694.4 €