Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Novel GIST Therapies (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Gastrointestinal stromal tumour (GIST) is the most common subtype of sarcoma in humans and its initiation and progression is predominantly driven by constitutively activating mutations in the receptor tyrosine kinase (RTK) KIT. This dependency on KIT led to the approval of kinase inhibitors for the treatment of GIST. Inhibition of KIT activity is effective at treating GIST in the short-term however, the majority of patients eventually develop resistance. This resistance is predominantly due to the emergence of additional KIT mutations. Therefore, the development of alternative KIT targeting therapies, beyond the current state-of-the-art, is paramount for the effective treatment of GIST in the long-term. One such strategy is targeted protein degradation (TPD). TPD is based on drugs called “degraders” which are compounds that induce the proximity between a protein of interest (POI) and components of the cellular proteolytic machinery resulting in the destruction of the former. Degradation of KIT offers several benefits over inhibition, that may combat resistance in GIST. Firstly, small molecule inhibitors rely on a strong affinity for the POI to be effective whereas degraders can maintain activity when the affinity for the target is compromised by mutations. Secondly, inhibition of protein function is not a requirement for degrader activity and therefore additional ligandable sites on the POI. In this project, I will employ a multifaceted drug discovery approach with the overarching aim of designing, identifying, and optimising degraders of KIT and investigate their effectiveness in GIST models. In order to explore the full potential of TPD in the treatment of GIST, I will pursue two different modalities of degraders: (i) bivalent (Objective 1) and (ii) monovalent (Objective 2). With a clear clinical translational goal in mind, the optimised degraders will be evaluated in various preclinical models of GIST (cellular and organoid) (Objective 3).

Mots clés : gastrointestinal, cancer, degraders, gist, organoids, receptor tyrosine kinase

Participants :
- Institut de recherche en biomédecine (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet FNIT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

This proposal responds to the need for a comprehensive framework to analyze the Water-Energy-Food (WEF) nexus and its impacts on socio-environmental issues. The framework will address such complex issues in the transboundary region of the Euphrates and Tigris Rivers Basin (ETRB), with a focus on climate change, migration, and gender vulnerabilities. The FNIT project will determine the effects of WEF trade-offs on socio-environmental issues by considering various stakeholder viewpoints, generating future scenarios, and assessing long-term risks. This project employs qualitative and quantitative methodologies based on four steps: 1) a diagnostic assessment of the ETRB region’s current situation; 2) scenario planning to generate robust future scenarios; 3) social network analysis to assess socio-environmental impacts; and, 4) integrated nexus governance to achieve systemic integrative outcomes. The FNIT project aims to involve a broad range of stakeholders from the four countries of the ETRB region, e.g., Iran, Iraq, Syria, and Turkey. The participatory approach develops systemic thinking, citizen science, and science diplomacy while minimizing the potential for international conflicts. The results, including the framework, scenarios, and vitalization tools, serve as a fundamental cornerstone and invaluable strategic resource for nexus analysis. These tools, focusing on socio-environmental issues, provide policymakers with a holistic perspective on transboundary matters, helping to mitigate inequality and displacement risks and democratizing policy insights. These results are designed for ease of use with publicly available and open-source data. Additionally, FNIT plays a pivotal role in assisting the European Union in identifying potential socio-environmental risks from the ETBR region that threaten Europe's socio-economic sectors in the future.

Mots clés : water energy food nexus transboundary rivers scenario foresight analysis climate change migration gender and climate equity participatory stakeholder engagement, network analysis

Participants :
- Université de Naples - Parthénope (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut international pour l'analyse des systèmes appliqués (Autriche) — Coordinator, beneficiary, Recherche, subvention : 183600.96 €
Projet Changing World (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Established Mycenaean palatial systems collapsed during generalised socio-political crises in the eastern Mediterranean at the end of the Bronze Age. Fundamental questions about the social impact of these irreversible transformations remain with implications for fully understanding diachronic human responses to significant environmental and cultural stressors. Changing World aims to evaluate how social collapse interfered with cultural processes as expressed in metallurgy and lifeways. I will examine 150 metal objects (warrior equipment, jewellery, tools, utensils) microscopically, elementally, and isotopically from 5 key sites in Greece (Elateia, Lefkandi, Pefkakia, Voudeni, Nichoria) for investigating resource management strategies, metalworking choices, and supply networks during 1300-1000 BC. I will then integrate the metallurgical results with bioarchaeological data (aDNA, stable isotopes) on relatedness, sex, and diet from >300 individuals from Elateia and Voudeni to shed light on changing worldviews embodied in craft practices. This transdisciplinary methodology will offer new theorised multi-proxy insights that will directly inform ongoing academic debates about the nature of the Mycenaean collapse, and will open new pathways for future research on materials and humans, and for the study of societies in crisis. This project is now possible through combining my extensive analytical skills and access to highly representative, newly available study materials, Prof. Stockhammer’s (PI; LMU) recent and ongoing bioarchaeological research in Greece, and Prof. Degryse’s (secondment PI; KU Leuven) expertise in metals provenancing. My analytical (MC-ICP-MS) and theoretical training (Practice Theory) and critical understanding of aDNA data, alongside additional training in teaching and student supervision, will strengthen my profile for attaining a tenured position at a university and attracting future EU research funding, as well as my competences outside academia.

Mots clés : archaeological science archaeometallurgy archaeogenetics late bronze age archaeology

Participants :
- Université Louis-et-Maximilien de Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
- KU Leuven (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet DE CADMEA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Brass, a copper-ziBrass, a copper-zinc alloy, is a major alloy from Roman period and throughout the Middle Ages and early modern period. Despite its importance, relatively little systematic research has been done on its production, and archaeological evidence is less well documented than that for copper and iron smelting. One reason for this is the unassuming nature of most zinc ores and zinc-rich furnace remains, compared to the more easily identified copper or iron slags. DE CADMEA aims first to develop a systematic overview of zinc-rich materials, and related furnace remains from one of Europe's best-studied medieval mining and metallurgical regions, the Harz Mountains, before applying the experience gained onto another important mining region, Cyprus. Little is known about the exploitation of zinc in Cyprus, despite detailed and consistent references in key classical texts to the exploitation of 'earthy substances', described in a way that makes their identification as zinc/brass raw material highly likely, and several indications for zinc-rich smelting remains in the analytical literature. In collaboration with local archaeologists and geologists, the PF will systematically search for evidence for zinc-related metallurgy, broadening the current near-exclusive focus on copper metallurgy in Cyprus. DE CADMEA is an ambitious project producing an up-to-date review paper on historic brass raw materials and production technology, and potentially unravelling a totally new chapter in the metallurgy of Cyprus. The proposal also offers insight into the exploitation of non-standard earthy compounds that may be connected with other types of early metallurgy, such as the silver one. The fellowship is sided with two secondments: the Department of Mining Archaeology in Goslar, for the study of the mining district of Rammelsberg in Germany, and the Deutsches Bergbau-Museum Bochum (DBM) which will support the research with the archaeometric characterizations and interpretation.

Mots clés : early metallurgy cyprus zinc, cementation metallurgy, raw materials

Participants :
- Bureau de contrôle et de gestion de la recherche et de l'innovation ( Cyprus Institute) (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 164328.0 €
- Niedersächsisches Landesamt für Denkmalpflege (Allemagne) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Dmt-gesellschaft fur lehre und bildung mbh (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet FluorineID (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Per- and polyfluoroalkyl substances (PFAS) encompass potentially millions of synthetic compounds that are widely used in modern society. These “forever chemicals” are extremely persistent, harmful to health, and are widespread globally. Despite advancements in their analysis, high levels of unknown fluorine—termed “PFAS dark matter”—persist in the environment, indicating that most fluorinated compounds remain unidentified. "PFAS dark matter" can originate not only from PFAS but also from many other emerging fluorinated compounds, including ionic liquids. Cutting-edge non-target screening (NTS) with high-resolution mass spectrometry (HRMS) can detect thousands of chemicals like PFAS but is typically only qualitative and limited in scope. FluorineID aims to address this gap and to unravel the “PFAS dark matter” by developing computational quantitative NTS (qNTS) methods that (1) integrate key chromatographic separation platforms for broader chemical space coverage, (2) prioritize the millions of fluorinated compounds in the online database PubChem for efficient and comprehensive identification, and (3) apply machine learning to quantify fluorinated compounds. The combination of individually identified and quantified fluorinated compounds with total fluorine measurements will allow verification via fluorine mass balance approaches. FluorineID will advance the identification and quantification of unknown fluorinated compounds, support identifying the origin of unknown fluorine in the environment, and offer open source qNTS workflows to accelerate future community-wide identification and risk assessment of “PFAS dark matter”.

Mots clés : quantitative non target screening qnts , high resolution mass spectrometry hrms , per and polyfluoroalkyl substances pfas , fluorinated compounds, fluorine mass balance

Participants :
- Université du Luxembourg (Luxembourg) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 247553.28 €
- Université de Stockholm (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet CRYSTAL-X (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Diffraction and serial crystallography serve as essential tools for comprehending the functions and dynamics of proteins. However, a significant limitation to their application lies in the consistent generation of protein crystals. Thus, it becomes imperative to explore novel avenues that can facilitate and regulate protein crystallization. Classical nucleation theory does not encompass the crystallization pathway for numerous protein solutions. This proposal seeks to offer fresh experimental insights into hidden intermediate metastable structures that are hypothesized to occur during the observed anomalous crystallization mechanism. Our objective is to explore in a non-equilibrium manner the anomalous crystallization of ferritin solutions in microdroplets and characterize its time evolution. The latter is going to be accessed via X-ray Photon Correlation Spectroscopy (XPCS), which will reveal the dynamic properties of both proteins and the amorphous phase that precedes crystal formation. Additionally, we aim to quantitatively assess the role of water in this system, pertaining to protein-protein interactions, hypothesized to depend on the water structuring in the vicinity of the interacting surface. Capturing the desolvation process is crucial for the understanding of the molecular mechanism underlying the different crystallization pathways, since it has been hypothesized that the efficiency and directionality of the desolvation leads to a higher (‘classical’) or lower (‘nonclassical’) degree of protein ordering in the initial aggregates. The candidate has a strong background in experimental methods sensitive to protein dynamics and joins the host group which specializes in water experiments with microdroplets. The project utilizes the unique coherent properties of European large scale facilities, such as the European Synchrotron Radiation Facility (ESRF) and European X-ray Free Electron Laser (Eu-XFEL).

Mots clés : protein crystallization, protein diffusion, coherent x ray scattering

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
Projet HI-GEN-SHARE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Health inequalities are a major concern in all European countries, however, these disparities are still marked inside societies. The literature on health inequalities has focused mainly on single-country studies and with a limited time span such as early conditions or late life situation of individuals. However, a cross-country longitudinal approach is fundamental to tackle the origins and evolution of health inequalities and to understand the heterogeneity of these type of disparities with a geographical perspective. In this setting, the focus on gender health disparities has not been addressed exhaustively yet. The main approaches have proposed a biological ground under which male-female differentials in health outcomes occur; or a social approach where different health risks are associated based on the gender. However, the economic discipline can contribute to advance the understanding of gender health inequalities by exploiting individuals and administrative data, along with novel quantitative econometric analysis; to investigate whether gender health disparities take place based on the health services provision. This project aim to address these fundamental issues by taking advantage of the Survey of Health and Retirement in Europe (SHARE), in a cross-countries longitudinal set up. Administrative data about the healthcare supply from EUROSTAT will be linked to understand gender health disparities. The focus of this project is critical, even more in the context of the current COVID-19 Pandemic, which have put the societal welfare under strain. The outcomes of the project will advance the comprehension of health inequalities, help in reducing gender health disparities and support policy reforms in the healthcare systems, all over Europe. This project will provide me with the necessary competences and enforce my econometric skills and management proficiency, to establish myself as an independent research leader in the field of health economics in Europe.

Mots clés : health inequalities, gender health inequalities, healthcare systems, share, longitudinal data, causal inference

Participants :
- École d'économie de Paris (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 207266.88 €
Projet NRCG (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Gravity is the fundamental force that is an integral part of our daily lives. Despite its ubiquity, one of the most open questions in theoretical physics is whether gravity is a geometrical phenomenon, as Einstein proposed, or governed by the law of quantum mechanics. This question leads to the formulation of a still-unknown framework called quantum gravity. A predominant model to address this problem is 3D gravity, which contains the same conceptual features as 4D Einstein theory. For decades, it has been a concrete model of quantising gravity with applications to black hole mechanics, spacetime solutions and their relation to condensed matter models, and the most fertile scenario to apply the AdS/CFT correspondence. This project focuses on formulating an intriguing new corner of 3D gravity. The latest sector is called non-Lorentzian 3D gravity, and time and the other spatial dimensions are dealt with differently as relativistic theories. I will study the foundations and dynamics of this self-contained sector with applications to the quantum Hall effect. My knowledge of non-Lorentzian topics has been gained during my PhD at CECs (Chile) and Niels Bohr Insitute (Denmark) and my postdoctoral position at the University of Iceland (Iceland), where I collaborated with world experts in non-Lorentzian aspects of physical systems. Therefore, this background on non-Lorentzian limits of physical systems makes me excellently suited for exploring other new sectors in gravity, and MCSA-PF provides me with the support to make it. The skills of this cutting-edge research will be transferred to the host organisation, Nordita and Stockholm University, via my long-term collaborations with leading institutions in the EU and Latin America. The varied research spectrum within its faculty members and postdocs makes Nordita an excellent environment for this project. The host, the EU, and I will benefit from the collaboration between the scientific networks this project will bring.

Mots clés : 3d einstein gravity, ads cft correspondence, asymptotic spacetime structure, non lorentzian gravity theories, quantum hall effect

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 236340.0 €
Projet PsyHab (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The lateral habenula (LHb) and dorsal raphe nuclei (DRN) are key structures in the brain involved in mood regulation, reward processing, and aversive signaling. The LHb is a small, yet critical brain region that acts as a major negative regulator of midbrain dopamine systems. It plays a significant role in processing aversive stimuli and encoding negative reward prediction errors, which are crucial for adaptive behaviors and decision-making processes. The DRN, on the other hand, is the primary source of serotonergic projections to various brain regions and is a key structure involved in mood regulation and the pathophysiology of depression. Understanding the precise anatomical and functional connections between the LHb and DRN is essential, as disruptions in the LHb-DRN circuitry are believed to contribute to various neuropsychiatric disorders, including depression and anxiety.  Psychedelics have garnered significant interest in both clinical and neuropharmacological research due to their profound effects on perception, cognition, and mood. Their influence on the activity of the LHb is not yet fully understood, but we hypothesize that it could potentially reduce the hyperactivity of the LHb by altering its neural inputs or by modulating the overall excitability of the neurons within the LHb. The proposed research is aimed at examining how psychedelics affect LHb-DRN circuitry in the chronic mild stress model of depression. We will combine viral tracing, in situ sequencing, fiber photometry, chemogenetics, and unsupervised learning in order to evaluate the effects that psychedelics exert on projections from DRN to LHb, and how those translate into changes in animal behavior. The proposed research will contribute to a better understanding of the antidepressant potential of psychedelics and help to improve pharmacotherapy of affective disorders. The applicant will acquire new skills, and the experience to launch and lead his own research group in the future.

Mots clés : lateral habenula, dorsal raphe nuclei, psychedelics, animal models of depression, in situ sequencing, fiber photometry, dreadds, unsupervised learning, psilocybin, doi

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 236340.0 €