Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ORGhvCAT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Photoredox catalysis has become a quintessential part of organic synthesis and gained wide interest in the chemical industry as a mild and robust synthetic methodology. Acridinium salts are a prominent substitute for transition metal-based photocatalysts (PCs) due to the modularity of the core, which makes them and structurally related dyes an optimal platform for structure-property tuning. However, a limited understanding of how structure influences reactivity prevents rational design, while the synthetically realizable chemical space is far too vast to explore using even high-throughput experimental methods. The objective of the proposed action is to study computationally the elementary mechanistic steps integral to photoredox catalysis to establish how they are each influenced by PC structure. We will develop an automated workflow for high-throughput computational molecular PC construction and analysis, in which known molecular fragments are coupled together by chemically precedented steps. Finally, Bayesian optimization will be used to guide the machine learning model building. This is distinct from conventional approaches in the field as we aim to increase the quality of our model with mechanistic understanding from quantum chemical calculation. My expertise in the fields of synthetic, physical, and computational organic chemistry, provide me the necessary skillset and ability to learn new concepts and successfully execute this project. The gained knowledge and results from the project will be an asset and help to build sustainable processes in the chemical industry in EU. The work will be implemented in the research groups of Prof. Robert Paton and Prof. Jeremy Harvey, with a secondment period in the group of Prof. Abigail Doyle. The investigators’ combined expertise ranges from computational and empirical reaction mechanism study to data sciences, and hence enables the project to incorporate complex mechanistic information to rational PC design.

Mots clés : organic dyes, dft, dual nickel photocatalysis, bayesian optimization

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 290444.16 €
- Colorado State University System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet STRESSLESS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Our climate is changing, the world population is still growing and our planet has finite resources; these are well-known facts. Developing improved crop varieties is crucial to ensure that our agriculture is well-prepared for increased environmental stress, can maintain high yields and utilises less resources such as fertiliser or available land. One key aspect is to prepare our crops for abiotic stresses such as saline soils and drought, two factors which are rapidly increasing world-wide, including the EU. Many abiotic stress-tolerance mechanisms have been described through lab-based studies, yet they are notoriously difficult to translate into field grown crops. Therefore, the here proposed project, STRESSLESS, will tackle this issue by taking a different approach. STRESSLESS is primarily based on observations in the crop soybean (Glycine max), with additional observations made in rice (Oryza sativa), and aims to identify the cellular mechanism contributing to improved plant growth, going from crop-observed phenotypes to in-depth analysis in the model plant Arabidopsis (Arabidopsis thaliana) instead of vice versa. Ultimately, STRESSLESS aims to contribute to preparing our crop plants for a sustainable, yet still profitable future agriculture.

Mots clés : plants, ion transport, salt stress, drought stress, guard cells, endomembranes

Participants :
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université rhénane Frédéric-Guillaume de Bonn (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet REDIRE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

If much has been said about the use of radio by the Italian fascists to establish and lead a regime that they wanted totalitarian from its advent, other devices of technicized sound, especially discs and their political affordances and effects, have been neglected. However, discs and phonographs were among the first technical sound devices and media to be available for political propaganda. Since the end of the 19th century, they have enabled political actors in the USA and Europe to transcend the time and space of their practice and to multiply their presence. In the interwar period, discs and recorded sound became fundamental parts of propaganda devices designed to elicit ideas, behavior, and adherence to a political project from massive audiences through sound. It appears then necessary to question the political functioning, the practices, and the social effects of propaganda discs, alone or associated with the radio or the loudspeaker, especially in a regime that its actors wished totalitarian. With "REcorded Sound PropaganDa of the Italian Fascist REgime" (REDIRE), I wish to inform the political role and effects of discs in the context of Italian fascism and to participate to the reflection on the political functioning of (technicized) sound, especially in a totalitarian regime. To do so, I will study the propaganda conceived by the regime to support the policies of development or perpetuation of fascism in time (education, identity, conservation and manipulation of cultural heritage) and space (colonization, war, transnational soft power, international existence of Italy). Through an investigation of the State archives and the press, I will examine the political uses of recorded sound engaged by fascist socio-technical networks, from their imaginary conception to their realization and their social effects. Finally, fascist and nazi recorded sound propaganda will be compared to better understand the political functioning of sound in a totalitarian regime.


Participants :
- Université de Cagliari (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université rhénane Frédéric-Guillaume de Bonn (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet RhythMEC (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Heart failure is a major cause of death in the Western world, with an estimated prevalence of 2-3\% of the population. A subgroup of heart failure patients is characterised by dilated cardiomyopathy (DCM) which results in substantial morbidity and mortality due to progressive mechanical pump failure (70\%) or sudden cardiac death from ill-predictable electrical disturbances (30\%). DCM is commonly linked to mutations encoding cytoskeletal proteins, but our understanding of why a loss of cardiac myocyte cytoskeletal integrity in inherited DCM phenotypes results in detrimental changes to calcium handling, and how this causes arrhythmias and sudden cardiac death, remains limited. Human studies have associated genetic mutations and loss in the cytoskeletal protein filamin C (FLNC) with arrhythmogenic DCM and sudden death. To explore the biomechanical and mechano-electric mechanisms by which FLNC deficiency leads to mechanical and electrical dysfunction, I will use experimental and mathematical models that span multiple spatial and temporal scales from the protein level up to the whole heart. I hypothesise that FLNC regulates myofilament lattice spacing and that loss of this structure leads to impaired contractile force development by the sarcomere. I postulate that these perturbations in mechanics may contribute to the generation of substrate for the induction and maintenance of lethal ventricular arrhythmias via a variety of mechano-electric coupling mechanisms. Particularly, stretch-induced alterations may affect cardiomyocyte electrophysiology, which may contribute to both the trigger and the substrate for arrhythmias. Thus, altered myocardial mechanics in the FLNC-null mouse model of DCM may contribute to the triggering or maintenance of life-threatening reentrant ventricular arrhythmias via a variety of mechano-electric coupling mechanisms.

Mots clés : ilated cardiomyopathy heart failure mechanics electric coupling multiscale modelling murine models electro mechanics computational modelling

Participants :
- Université de Fribourg-en-Brisgau (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265647.84 €
- University of California System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université rhénane Frédéric-Guillaume de Bonn (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet CrisEU (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Due to recurring economic and political shocks, the past decade has consolidated crisis-management and resilience as a key priority of the European Union (EU). Academic research has long interrogated the ways in which crises are dealt with at the European level. Yet, the excessive emphasis on electoral trends or elite-led processes has failed to capture the long-term quiet politics of support towards European integration. The role of European progressives, a key source for the European ideals of solidarity and internationalism, has received little attention. This is surprising given the fact that progressive politics and European integration have both experienced a long series of mutations and adaptations shaped by recurring crises. While these processes have been studied separately, little attention has been given to their intersection. As a result, progressive politics has been conceptualised as a passive victim of increasing integration and the EU is often seen as squeezed in the middle between populism and technocratic decision making. CrisEU will build a theoretically informed and impact-oriented study to investigate the ideas and group characteristics that through critical junctures create long-lasting support to integration. The main hypothesis I will investigate is that progressive politics is ‘reinvented’ at different stages in relation to three interrelated factors: 1) The changes in the composition of left-wing social networks (in relation to gender, age, education, etc.); 2) The evolving memories of past crises; 3) The shifting understanding of what is needed to ensure Euorpean integration. Beyond academia, the proposed research will help political parties and trade unions identify the factors that drive (dis)integration within the EU, the ways in which memory informs crisis-management and the role played by social networks' pluralism in driving policy innovation.

Mots clés : european integration crisis management left wing parties trade unions

Participants :
- Institut universitaire européen de Florence (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 277159.2 €
- University of California System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MeStaLeM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The oomycete pathogen Albugo laibachii plays an important role in structuring the phyllosphere microbiome of Arabidopsis thaliana. Plant-associated microbial communities are known to provide protection against pathogens, at least in part, through the production of specialised metabolites that suppress the activity of pathogen-derived proteases. Thanks to the advances in next-generation sequencing and non-targeted mass spectrometry, we have gained new insights into the community and metabolic dynamics of the plant microbiota. Nevertheless, we are just at the beginning of fully capturing the sheer number and complexity of the community members and the countless, still unknown, metabolites they produce. The molecular mechanisms underlying microbe-microbe and plant-microbe interactions remain thereby mainly elusive. So far, only a few metabolites have been identified as plant-protecting agents but the full protective potential of a microbiome through the synergistic action of multiple microbial compounds remains largely hidden. To shed light on the bioactive potential of the exo-metabolome of the plant microbiome as a whole, I will apply a multi-modal functional metabolomics strategy that provides information on the potential protease inhibitory activity of all the compounds secreted by a predefined synthetic microbial community. Our focus will be on the stabilisation of the microbial community composition mediated by protease inhibition and the related plant-beneficial activities through synergistic interactions with other defence strategies. Connecting those activities to individual metabolites will allow us to better understand the beneficial effects of the community as a whole and how dysbiosis may contribute to pathogenesis. It will also allow for the rational design of next-generation microbiome derived biocontrol agents which are urgently needed for a more sustainable agriculture.

Mots clés : microbial community, cross feeding, plant microbe interaction, microbial community common good, microbial community function

Participants :
- Université Eberhard Karl de Tübingen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
- University of California System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet READMODE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Development of sustainable and resilience infrastructure is very important because particularly in Europe, building structures are accountable for materials extraction, CO2 emissions, and energy consumption. The decline of residential building impacts is one of the crucial goals identified by the European Union (EU) to meet the Paris goals and move forward for circular economy. Therefore, REliability and risk Assessment of flexible MOdular structures with vibration control DEvices in multi-hazard environments (READMODE) project proposes an innovative approach to analyze the reliability and risk of modular structures. In this project, a probabilistic approach is considered to increase the accuracy of structural reliability and risk assessment. It contains the development of improved mathematical models for the reliable and resilient infrastructures. Also, a detailed novel solution will be given for enhancement of resiliency in the modular buildings. The output of this research will provide cost-effective and time-saving techniques for resilience improvement. The fellowship will lead to closer cooperation and knowledge transfer between researchers at host and between different sectors. The research findings specifically, and my personal enhanced competencies generally, will lay the groundwork for future theoretical study in resilient infrastructures. Most European countries are already developed and contain many existing structures and infrastructures that need to be resilience. This will prepare authorities for potential changes in design approach and calculations for future projects and will have significant impact on understanding the risks and safe design of resilient infrastructures.

Mots clés : reliability and risk, response mitigation, modular buildings

Participants :
- Université Gottfried-Wilhelm-Leibniz de Hanovre (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet AOT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project “Arcs of Time: Zoroastrian philosophical anthropology” (AOT) explores a new area of Zoroastrian thought by combining philological and philosophical methodologies to a more holistic understanding of the textual sources. Zoroastrian philosophical anthropology analyses the person as an historical composite, whose spiritual and material parts change over time. So, the AOT project analyses both the historical part of this theory, including debates on the origin of humanity and on the cyclical nature of human history, and it also analyses the constitutive part, including debates on psychophysical composition and on human wisdom. Its objective is to produce philosophically precise translations of 40 chapters from Dēnkard III that exhaust both parts of Zoroastrian philosophical anthropology. Dēnkard III is a medieval encyclopedia of Zoroastrian thought, and it is preserved in a single problematic manuscript. Contemporary scholars are now turning their attention to the Dēnkard.  The method is a philosophically-informed philology. It will first produce critical editions from the problematic manuscript, and adduce linguistic parallels within the wider Zoroastrian literature from this period in order to ensure philological accuracy. It will second produce a rational reconstruction of the philosophical worldview expressed in the texts, and adduce conceptual parallels within both the Zoroastrian literature and the literature in Arabic contemporary to the authors of the Dēnkard in order to ensure philosophical accuracy. The philological work will be uploaded to an open-access online database for scholarly collaboration and for the general public; the philosophical work will result in two open-access articles meant to explain the technical details of the translations to audiences not specialized in the Dēnkard or Zoroastrian thought.

Mots clés : zoroastrianism, iran, islamic studies, religion, philosophy, 

Participants :
- Université libre de Berlin (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de la Ruhr à Bochum (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet CLaRMaV (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Coastal heritage is increasingly at risk from both natural and man-made factors, and is therefore crucial to document it before it disappears. Maritime villas, a common feature of the Roman Mediterranean, are very important for understanding the development of ancient urbanisation and architectural forms, the interaction between humans and the environment, and the use of natural resources. Yet, an overall study looking at the architecture of Roman maritime villas in the Mediterranean regions and how they impacted on, and were shaped by, their local environments is lacking. CLaRMaV will investigate the typology of Roman maritime villas across the Mediterranean Basin (2nd century BC-6th century AD). It will do so by studying the architectural models adopted and developed in the various regions; the prevailing trends over time; the use of individual architectural spaces; and the role of these villas in the local economy. The project will focus on the dialogue between domestic architecture and the environment and look at the use of available natural resources. Special attention will be given to water usage and to whether any water-saving measures were put in place to address its scarcity in some regions. This project, with its multidisciplinary nature, will contribute to the knowledge of the architectural, environmental, and socio-economic histories of the Roman Empire. By incorporating in its methodology the use of GIS and 3-D reconstructions, the resulting outputs will be of use to archaeological sites and museums, both in managing the sites and in offering educational resources to visitors. The coastal environments occupied by ancient maritime villas are seriously impacted by coastal erosion, rising sea levels due to climate change, and anthropic actions. Therefore, it is vital to systematically record and study these structures. The data generated by the project will be useful to local authorities in charge of preservation of coastal heritage and urban planning.

Mots clés : coastal heritage, preservation and promotion, architecture, roman maritime villas, mediterranean landscape, ancient urbanism, natural resources, water usage and recycling, socio economic histories

Participants :
- Université de Bologne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €
- Université de Pennsylvanie (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MUSICIAN (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Cochlear implants (CIs) have been tremendously successful in restoring speech communication for deaf people. However, the enjoyment of music through CIs is still quite limited. The objective of the proposed project "MUSIc processing for Cochlear Implants based on Auditory and Neural modelling" (MUSICIAN) is to extract and transmit the most prominent features of music (rhythm, pitch, timbre) such that the listening effort of CI users is reduced and their music appreciation is improved. To this end, we propose to perform fundamental research into measuring and modelling the CI user's music perception and to develop improved processing methods capable of simplifying music signals to their most essential aspects. The project thus addresses the information bottleneck composed of the electrode array and its interface with the auditory nerve and will help to reduce the perceived distortions of music in CI listeners. Within the proposed programme, two labs with extensive experience in signal processing and audiology, the Institute of Communication Acoustics at Ruhr-Universität Bochum, (beneficiary residing in Bochum, Germany) and the Auditory Engineering Laboratory at McMaster University (associated partner residing in Hamilton, Canada) will host the experienced researcher Dr. Anil Nagathil who is a pioneer in the development of music processing methods for CIs. The proposed interdisciplinary project will enable Dr. Nagathil to acquire knowledge from several scientific domains and to integrate this expertise into the methods of auditory modelling and music processing. The outcome of this project has a substantial commercial impact and the potential to improve the quality of life of hundreds of thousands of CI users worldwide.

Mots clés : cochlear implants, music processing, hearing science

Participants :
- Université McMaster (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de la Ruhr à Bochum (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 280751.52 €