Projet METAMIC 3 (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

One Health is an integrated, unifying approach that aims to sustainably balance and optimize the health of people, animals, and environment ecosystems. All three domains are interconnected by microbiomes. Microbiomes are present universally and are connected by species exchange, impacting human and animal health but also environmental and biotechnological processes. Targeted control of the taxonomic and functional microbiome composition by microbial effectors such as antibiotics, antimicrobial peptides, and phages could be a game changer for these fields. However, the impact of microbial key factors on modulating microbiomes, the mechanisms implicated and the functional consequences, are barely understood. A novel approach which provides unique insights into the dynamics and the roles of microbial effectors is metaproteomics. The metaproteomics approach allows us to quantify the microbial composition and the expressed metabolic functions as well as to detect phages, antimicrobial resistance associated proteins, and non-ribosomal peptides. Leading European scientists of the Metaproteomics Initiative (https://metaproteomics.org/) formed a strategic alliance to set up a powerful and interdisciplinary network called METAMIC to capitalize on the potential of metaproteomics for developing novel strategies for microbiome control, manipulation/engineering, and restoration based on microbial effectors. METAMIC will achieve this by training a new generation of highly skilled microbiome and metaproteomics scientists, spreading their knowledge in research, industry, the medical sector, and public authorities. Developing novel metaproteomics workflows and exemplifying them in various clinical and biotechnological field studies will provides important steps towards better understanding and managing our microbiomes in the future, fitting the key EU missions, including “climate change”, “climate-neutral and smart cities”, “soil deal”, “restore ocean and water”, and “cancer”.

Mots clés : metaproteomics, microbiome management, fecal microbiota, multidrug resistant systematic infections, omics, one health

Participants :
- Université de Montpellier (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Érasme de Rotterdam (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Lille (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Phylogene (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, beneficiary, Recherche, subvention : 290272.32 €
- Anhalt University of Applied Sciences (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 290272.32 €
- Université de Bielefeld (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Forschungszentrum Jülich (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université du Luxembourg (Luxembourg) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 288540.0 €
- Université de Cagliari (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Gand (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 288540.0 €
- Myria biosciences ag (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Leibniz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 580544.64 €
- Agro innovation international (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Partner, beneficiary, Recherche, subvention : 282188.16 €
- Helmholtz Centre for Environmental Research (Allemagne) — Partner, beneficiary, Recherche, subvention : 290272.32 €
- Université de Sassari (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281755.08 €
- Université de Sheffield (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Vienne (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université autonome de Madrid (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Hohenheim (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 290272.32 €
- Université de Leipzig (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Marbourg (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre hospitalier universitaire de Montpellier (France) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Commissariat à l’énergie atomique et aux énergies alternatives (France) — Partner, beneficiary, Recherche, subvention : 629338.32 €
- Fagoterapia lab s.r.l. (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Microviable therapeutics, s.l. (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Robert Koch Institute (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de technologie de Delft (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 610571.52 €
- Université de Pise (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281755.08 €
- Ministère de la Santé (Luxembourg) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €