Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MOFCatEthanol (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Dr Qing Wei would like to start within 12 months of the signature of the Grant Agreement due to the uncertainty regarding travelling and the longer time required for visa application and relocation arrangements due to Covid-19. The effective start date will be notified 2 months before the intended start of the fellowship.

Mots clés : cellulose, ethanol, zifs, hzifs

Participants :
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet SOFT-TISSUES (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

Dr Valentina Balbi is an Italian national, trained in Applied Mathematics in Italy and in Mechanics in France and at Stanford University. She publishes articles in high-impact factor journals, at the frontiers of applied mathematics and other disciplines. She is requesting funds for two years, to work with Professor Michel Destrade and join his group of Biomechanics at NUI Galway, Ireland. The overall scientific aim of the Project is to improve understanding of the nonlinear mechanics of soft biological tissues, including growth, buckling and pattern formation, mechanics of organs such as the eye, the brain and the skin. Ongoing work in these areas is still in its infancy, and the project proposes a bottom-up approach to their investigation. There is particular attention placed on applications of the results to biomedical engineering, numerical simulations and engagement with the general public, especially through a judicious choice of secondment periods. As the work progresses, the emphasis will shift from theoretical modelling (relying on the Applicant’s expertise) to experimental validation and numerical simulations (using the Host Laboratory’s expertise and facilities), with a view to medical applications (taking advantage of the partners institutions’ experience in training, communication, scientific management, intellectual property, etc.) The training programme is exhaustive, and will allow the researcher to grow as a world-class leader for these issues, which are fundamental in healthcare for the benefit of society. She will possess a unique blend of knowledge and expertise, allowing her to communicate and work with applied mathematicians, biomedical engineers and clinicians in industry, health services and academia.

Mots clés : soft tissues, skin, brain, morphogenesis, nonlinear elasticity, linear and nonlinear stability analysis, buckling, numerical simulations, finite element methods, experimental techniques

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet Micropod (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Dr. Eoin O’Cearbhaill, a Biomedical Engineer, recently returned to Ireland to become a Lecturer in Bioengineering at University College Dublin. This fellowship will enable him to work with Prof. Michael Gilchrist to develop his career by implementing a research platform based on medical devices for therapeutic delivery, with a specific focus on microneedles. Microneedle transdermal patches are an important advance in the delivery of therapeutics, especially vaccines and biotech molecules. They offer advantages over the classic approaches of hypodermic drug delivery, (needle phobia, risk of needle stick injuries), oral delivery (degradation and poor intestinal permeability of biologics), and traditional skin patches (limited to passive delivery of small molecules). The traditional hollow needle design suffers from a scaling effect, limiting mechanical performance at the penetration depth required for efficient absorption and large molecule delivery. Current microneedle patches targeting transdermal delivery are often prohibitively expensive to manufacture and are prone to mechanical failure. Here, Dr. O’Cearbhaill proposes the development of microneedle patches with interconnected porosity, aimed at consistent, rapid delivery to dermal tissue, in close proximity to the capillary bed. This platform technology can also be applied to other minimally invasive devices designed to provide controlled therapeutic infusion to precise locations. The applicant will develop porous microdevices, using manufacturing techniques that are scalable and cost-effective, enhancing the commercial value and potential to rapidly translate this technology to patients. The reintegrating applicant’s proficiency in medical device concept development will synergise with the host’s expertise in computational modelling of penetration in soft tissue and micromanufacturing to aid in the applicant’s development as a leader in medical device design and innovation.

Mots clés : medical devices, microneedles, transdermal, drug delivery, microporous, biomedical, microporosity control, sintering

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187866.0 €
Projet MOLMIC (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Dr. Sven Lahme proposes to work with Prof. Ian Head at Newcastle University, UK, to study the Molecular Biology of Sulfide-Oxidizing Nitrate-Reducing Microorganisms Involved in Microbiologically-Influenced Corrosion (MOLMIC). Corrosion is a multi-billion Euro problem for the oil and gas industry. Microbiologically-influenced corrosion (MIC) in this sector is usually linked to souring of oil fields due to production of toxic and corrosive H2S by sulfate-reducing bacteria (SRB). Injection of nitrate into sour oil fields is a bioengineering strategy, which removes H2S by promoting sulfide-oxidizing nitrate-reducing bacteria (soNRB). However, recent reports involved soNRB in MIC due to incomplete oxidation of H2S to corrosive sulfur intermediates. The end products of soNRB metabolism vary depending on the ratio of sulfide to nitrate. This suggests that a predictive understanding of soNRB metabolism and appropriately adjusting the nitrate dosage can prevent the risk for soNRB-mediated MIC. MOLMIC will investigate the ecophysiological role of soNRB in oil field corrosion by using isolated cultures, specific enrichments and complex communities. It aims to i) understand the sulfur metabolism of oil field soNRB by gathering genomic and transcriptomic information through next-generation sequencing, ii) link different soNRB metabolisms to corrosion by monitoring corrosion rates and gene expression under various conditions and iii) evaluate soNRB MIC and countermeasures in complex communities by testing different nitrate dosing strategies and predictive genetic diagnostics. Dr. Lahme will expand his skills in microbial physiology and molecular biology acquired in Germany and will be introduced to petroleum microbiology, bioengineering and electrochemical techniques. New academic and industrial collaborations will emerge, which are both essential for becoming an independent and leading researcher.

Mots clés : petroleum microbiology, souring, nitrate treatment, biocorrosion, nitrate reducing microorganism, sulfide oxidizing microorganism, next generation sequencing, gene expression

Participants :
- Newcastle University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet DRESSINGTHENEWWORLD (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Dressing the New World. The Trade and the Culture of Clothing in the New Spanish Colonies (1600-1800). What effect did the successful marketing of European products have on the New World at the beginning of the 18th century? And how should one go about studying the European Fashion and Textiles that transformed the way people dressed in the Spanish colonies? “Dressing the New World” research project is framed by a unique document, which describes Mexico in 1700s. This document is a rare reference for the knowledge of Spanish America at the beginning of the 18th century, and a very unique source to understand how and why Europe aimed to disseminate its textiles, commodities and fashionable goods overseas. The research project seeks to consider Early Modern Fashion in detail through this historical piece and other resources from literature, iconography and material culture, merging into different disciplines: Modern History, Art History and Dress History. Finally the research project aims to integrate the impact of politics and global connections in fashion studies for the early modern period. Official reports, political correspondence and accounts written by travellers are a rich source of information that allows us to write the history of fabrics and fashions and to study their impact, consumption and distribution in early modern times. Taken together these sources will offer a unique manner in which to envisage and articulate textiles and dress in the mix of cultures of the New World from the Spanish conquest in 1521 up to the 19th century, and map up how the global market connected different parts of the world in early modern time. Matched with a unique source of iconography (the “Casta paintings”), the achieved research will produce the first illustrated glossary on Textiles and Garments whose were consumed on a global scale in the preindustrial time.

Mots clés : fashion, design, clothing, textile, europe, america, history, art history, consumption, global, politics, trade

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet DropContEvo (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Droplet microfluidics has recently become one of the breakthrough technologies for high throughput screening in microbiology and biochemistry, including single cell studies and new approaches to in vitro evolution. Here we propose a development of a novel microfluidic system for unsupervised execution of multiple cycles of in vivo continuous evolution in hundreds of thousands of picoliter droplets. Each evolutionary cycle will comprise: i) encapsulation of single bacteria cells in water-in-oil compartments ii) growth of the cells coupled with production of economically relevant biomolecules iii) selection of the most efficient populations using ultra-high-throughput sorting of picodroplets, iv) dilution of each population via merging with 100 times larger nanoliter droplet containing fresh nutrients and v) passive splitting of each of the resulting nanoliter droplets to the libraries of picoliter droplets containing single cells. Confinement of the reaction in small volume and active sorting of droplets will facilitate and accelerate the process of in vivo evolution. Droplet format will also enable for various screening schemes, so far not available for continuous evolution strategies – e.g. based on high throughput fluorescence or absorbance measurements of the droplet content. The second stage of the project will comprise a series of proof-of-concept experiments presenting directed continuous evolution of the tryptophan synthase (TrpS) in E.coli bacteria. The technology proposed here would be very useful for broad community of biotechnologists, evolutionary biologists and industrial specialists without the experience in microfluidics. The proposed research will be conducted at Dr. Hollfelder´s laboratory that specializes in directed evolution of enzymes and application of microfluidics to industrial biotechnology. The project comprise broad and extensive training in research and complementary soft skills that will aid professional development of the Beneficiary.

Mots clés : droplet microfluidics, microengineering, continuous in vivo evolution, directed evolution, micro bioreactors, high throughput screening, mutagenesis, enzymology

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet ELECTRORGANO (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Drug discovery must identify successful lead candidates. As such, the development of new catalytic methods for the production of chiral molecules is extremely valuable. ELECTRORGANO seeks to synergistically combine two powerful modes of molecule activation, namely asymmetric organocatalysis and microfluidic electrochemistry, to provide an attractive new pathway for the formation of demanded chiral molecules. Both organocatalysis and electrochemistry possess extraordinary potential for the sustainable preparation of novel organic molecules, which are required to drive innovation within the pharmaceutical industry. However, the implementation of electrochemical methods for the design of stereoselective processes is still falling short, mostly due to the fleetingness of the radical ions intermediates generated on the electrode surface. ELECTRORGANO asks whether the use of an electrochemical microfluidic setup, coupled with asymmetric organocatalysis, can overcome these intrinsic limitations, rapidly providing chiral building blocks with high stereocontrol. Finally, mechanistic studies, aided by the use of in-line instruments, will provide fundamental understanding in the origin of the enantioselective induction, setting the stage for future breakthroughs in enantioselective electrochemistry. This project is highly interdisciplinary, involving different research areas such as asymmetric organocatalysis, electrochemistry, and microfluidics. As such, it is envisioned that the development of this new platform can generate breakthrough scientific papers, valuable discoveries and/or potential patents. This fellowship brings a two-fold transfer of knowledge: advanced techniques in asymmetric catalysis to the host institution and electrochemical methods and microfluidic flow chemistry to the fellow. Overall, the project’s multidisciplinarity and intersectoral nature will broaden the fellow’s competencies and will place him in a competitive position for his next career move.

Mots clés : flow chemistry, organocatalysis, catalysis, nhc catalysis, aminocatalysis, enantioselective reactions, electrocatalysis

Participants :
- University of Amsterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175572.48 €
Projet EVPERS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Drug transporters of the ATP-binding cassette (ABC) family (e.g., P-gp, MRP2 and BCRP) promote the intestinal, biliary and urinary excretion of a wide range of drugs and, thus, determine their bioavailability, therapeutic efficacy and toxicity. Transporter expression is highly variable between individuals and within the same individual. This may result in enormous differences in the plasma concentration of a drug, which for drugs with a narrow therapeutic index may result in life-threatening situations. Extraction of biopsies would be the only option to measure transporter expression in tissues and adapt the therapeutic strategy. However, this is not performed due to its invasive character. Extracellular vesicles (EVs) are nanoparticles released by all cells of the organism. Their cargo (proteins, RNA and lipids) is frequently a dynamic fingerprint of the cell. The presence of EVs from different tissues in blood and urine allows for an easy access. The aim of this project is to evaluate if the amount of ABC transporters in EVs from blood and urine can be used to specifically predict the transporter expression at the tissues of origin under basal and induced conditions, as well as to predict in vivo drug pharmacokinetics. Following work packages (WP) are proposed: WP I: EVs as dynamic surrogate for ABC expression in vitro and ex vivo. I.I. Validation of an analytical protocol for the quantification of ABC transporters in EVs, I.II. Correlation between ABC expression in biopsies and in EVs from the same specimens, I.III. Correlation between expression of ABCs in EVs from primary cells and the expression and activity of ABCs in the cells of origin under basal and induced conditions. WP II: EVs as biomarker for drug pharmacokinetics. II.I. Optimization of the immunopurification of circulating hepatic-, intestinal- and renal EVs, II.II. Correlation of ABC transporter expression in EVs with the pharmacokinetics of an ABC model substrate under basal and induced conditions.

Mots clés : abc transporters, atp binding cassette, extracellular vesicles, drug clearance, bioavailability, p glycoprotein

Participants :
- University Hospital Heidelberg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162806.4 €
Projet NARCOREADER (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Drug use continues to be a problem of major concern for public authorities worldwide. According to the World Drug Report elaborated by the United Nations Office of Drugs and Crime (UNODC) approximately 207,000 drug-related deaths occur per year. With between 162 million and 324 million people aged 15-64 having used an illicit drug — mainly substances belonging to canabinoids, opioids, cocaine or amphetamine-type stimulants group — at least once in the previous year, drug abuse continues to have devastating consequences on human health. The methods currently used to identify illicit drugs, such as colour tests, lack selectivity, and need further confirmation by expensive and time consuming chromatography-mass spectrometry methods, thus it is imperative to develop new sensing technologies that allow a fast, sensitive and selective detection of illicit drugs. This project proposes to develop novel, inexpensive and portable multisensing devices adapted for the rapid on-site screening of a number of illicit drugs, using recent advances in biomimetic materials coupled with electrochemistry. The multisensing devices will facilitate (1) detection and capturing illicit drugs crossing borders and (2) identification of drug users (e.g. drivers of vehicles at roadside, employees at work places, prisoners). In addition to rapidity and high selectivity of the detection, the sensing strategies will also give informations about (1) the type of drug and cutting agents (2) amount of drug present in biological samples. Moreover, the strategies employed will bring insights for better understanding of biomimicking nanoplatforms leading to more efficient technologies in health and biotech. The achievement of the actions goal will lead to reducing the incidence and prevalence of illicit drugs use and to a better management of drug-related problems with high societal impact. The underlying technologies will open doors for a broader range of applications.

Mots clés : illicit drugs, biomimetic receptors, electrochemical sensors, molecularly imprinted polymers, on site analysis

Participants :
- University of Antwerp (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €
Projet HiResCombs (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Dual-frequency comb spectroscopy is a seminal new way of measuring infrared transmission spectra with high signal quality in short measurement times. Quantum cascade laser dual-comb spectroscopy has recently been introduced for the measurement of solid state and liquid samples at low resolution. In HiResCombs, we develop two complementary methods to perform high resolution spectroscopy with quantum cascade laser frequency combs. Each of the methods will be proven in an application test in a suitable research application. With the developments of HiResCombs, we aim to offer improved measurement capabilities for two research fields at once: high resolution spectroscopy and research in gas phase kinetics on short time scales.

Mots clés : frequency combs, quantum cascade lasers, dual comb spectroscopy, high resolution spectroscopy

Participants :
- Irsweep ag (Suisse) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 191149.44 €
Projet Rev.E (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Due to its double nature (text and representation) theatre belongs to the literary domain while having specific aspects that binds it to its socio-historical context. During the considered era it is one of the most effective collective expressions of society. Its analysis allows a still topical reflection on institutional mechanisms of control of the freedom of art and press. Conceived with Prof. Astbury (University of Warwick host institution) and Prof. Frantz (Université Paris-Sorbonne secondment) Rev.E project has 2 objectives. First, the creation of a missing calendar of the Parisian repertory of the Consulate (1799-1804) related to a freely accessible online database (filled with unknown primary materials: press reviews, censors' or police reports etc.) that will be combined with an interactive website to allow a user-friendly gateway to explore it. Second, the investigation of the relationship between theatre and its broader context (1789-1815) to enhance critical reflection on a neglected corpus through an interdisciplinary approach (arts de la scène, history, history of theatre and of literature, history of mentalities, cultural policies). Findings will also be presented through themed seminars, an international conference (plus volume of proceedings), academic presentations, the submission of 3 articles to peer-reviewed journals and of the critical edition of Etéocle by Legouvé (1799). Public engagement activities for a non-specialist public will include talks (Coventry, 2021 Uk city of Culture), an online exposition (Costuming the Consulate), a school workshop leading to an online theatrical chronicle (1799-1804, key-dates) using tweets and radio interviews, and the staging of La femme à deux maris (Pixérecourt, 1802) at Porchester Castle. The collaboration with renowned scholars will increase the fellow's possibilities of being inserted in higher scientific networks. The acquisition of new DH competencies will be transferred back to Verona University.

Mots clés : french theatre, drama of revolutionary and napoleon era, french drama of the twilight of enlightenment, revolutionary and napoleonic cultural policy, history of theatre, french literature

Participants :
- University of Warwick (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €