Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CD28 (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Regulation of T cells has been a cornerstone in the development of therapeutics for fighting a wide plethora of pathologies, including cancer, chronic infections and disease. The mechanisms governing activation or repression of T cells depend on several receptors which provide “second signals” following the initial interaction with APCs presenting MHC complexes. Among these receptors, CD28 constitutes the main interest for this project. Its role as co-stimulator of T cell activity is known for so long. However, the particular mechanisms underlying its effective interaction with its cognate ligands (CD80/CD86) remain unclear yet. In particular, the present project is aimed at exploring the possible role of sialic acid in regulation of CD28 co-stimulatory activity (via inhibition), which could provide a novel explanation for the so-called “neuraminidase effect” described for decades. This effect leads to enhanced antigen-mediated T cell activation when sialic acids are enzymatically removed, but its origin is uncertain. Additionally, the structural basis for CD28 regulation will be explored, putting an special emphasis on its exploitation for the design of molecular platforms which may serve for reactivation of exhausted T cells in tumor models. The proposed project will be jointly undertaken by two renowned groups with large and solid experience in the field of glycomics, at CIC bioGUNE (J. Jiménez-Barbero) and Scripps (J.C. Paulson). The applicant, under their guidance, will develop the project from a very wide and cross-disciplinar perspective, covering all unknown aspects related to CD28 so far as well as proposing a novel methodology to translate this knowledge into valuable goods for society. The success of the project will likewise have a remarkable impact in the field of immunotherapy-based treatments for patients with cancer or chronic infections.

Mots clés : cd28, sialic acid, t cell co stimulation, t cell activation, sialidase, molecular recognition, chemoenzymatic synthesis, immunotherapy, chronic infection, cancer

Participants :
- Scripps Research Institute (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- CIC bioGUNE (Espagne) — Coordinator, beneficiary, Recherche, subvention : 245732.16 €
Projet MUSICAL (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Research in biology is both empowered and limited by the fluorescence imaging technology, which has witnessed a huge leap in resolution limits through super-resolved optical microscopy or also referred as optical nanoscopy. Over the last few decades, numerous optical nanoscopy techniques have been reported for either spatial or temporal resolution enhancement. Nevertheless, the present state-of-the-art of optical nanoscopy lacks to provide high optical resolution (50 nm or better) at high temporal resolution (~1 Hz) over large field of view (> 500 X 500 μm2) in live-cell friendly imaging conditions, such as without special buffer/fluorophores and with minimum photo-toxicity. In this proposal, the aim is to provide ~50 nm optical resolution at significantly small temporal scales (~ seconds) in photochemical environment which is physiologically conducive for in-vivo bio-imaging applications. This is achieved by incorporating complementary knowledge and intra-disciplinary skills on the computational nanoscopy (of the experienced researcher, ER) and chip-based optical nanoscopy technique (developed by the hosting PI). The aim is to apply Multiple Signal Classification algorithm (MUSICAL), a computational nanoscopy algorithm developed by the experienced researcher with the fluctuating illumination provided by waveguide chip-based optical nanoscopy developed at the host university, namely Universite it Tromsø, under the ERC funded project (Nanoscopy, PI: Ahuliwalia). The technique shall be used to image and understand endocytosis transport-highway of phages virus in liver endothelial scavenger cells.

Mots clés : super resolution optical microscopy, optical nanoscopy, bio imaging

Participants :
- UiT The Arctic University of Norway (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 208400.4 €
Projet ELICIT (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Research in the history of emotions has demonstrated that emotions are, at least in part, cultural objects subject to historical change. Present-day European emotional experiences and behaviours are informed by a cultural tradition of emotional standards and norms that are typical of European societies. Language plays a key role in this cultural tradition as a means for both labelling and expressing emotional experiences. However, how emotion language has changed in the history of Europe and how this change has been affected by the interaction of intra-linguistic and sociocultural factors is an area still largely unexplored. ‘Emotion Language in Italian: Change in Texts and time’ (ELICIT) is a historical-pragmatic corpus-based project that aims at filling this knowledge gap. The project will elucidate how emotion language in Italian evolved across different textual genres between 1750 and 1914. The Italian language has been chosen as a paradigmatic case due to its fortune as the language of emotions in literary genres (from lyric poetry to opera) and due to its peculiar dependence on written models of language. On the other hand, the years 1750-1914 are a period of paramount importance and evolution both in European emotion history and the Italian language. To implement this project, I will move from Australia to Stockholm University, where I will join the Department of Romance Studies and Classics. I will integrate my solid background in Italian historical linguistics, pragmatics and the history of emotions with specialist training in Italian eighteenth- and nineteenth-century philology, corpus-based methods, and quantitative approaches to modelling linguistic and cultural variation. Through an innovative quantitative and qualitative analysis of a large corpus of texts, I will demonstrate how the evolution of Italian emotion language was determined by the interaction between competing models of language and cultural norms of emotional expression.

Mots clés : historical pragmatics, emotion language, history of the italian language, corpus linguistics, history of the emotions, systemic functional linguistics

Participants :
- Stockholm University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203852.16 €
Projet iShape3DSeed (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Research on modern seeds has shown that their shape reflects the influence of environmental growth conditions, including cultivation regimes. However, no modern agronomical or archaeobotanical studies have so far exploited this immense potential of information encompassed in seed shape. The main reason is that shape in these disciplines is currently studied using geometric morphometrics (GMM) but, largely due to the small size of grains, this is limited to 2D and semi-3D landmark measurements that cannot take advantage of the full, complex shape of the crops. iShape3DSeed will tackle this problem by employing cutting-edge emerging technologies and a novel combination of high-resolution 3D modelling of seeds, geometric morphometrics and machine learning (ML). The aim is to develop a novel, non-destructive and low-cost methodological toolkit that will allow using the full 3D shape of seeds to provide in-depth interpretations on agricultural management and distinguish environmental impact. To do so iShape3DSeed will focus on cereals and will use material from the Greek Genetic Bank that includes pre-mechanisation crops with their growing information, experimental cultivation of traditional cereal varieties, and archaeological material from four Aegean Bronze Age sites. The modern material will be used to develop and test the new toolkit, and the ancient to allow and test its archaeological application. The modern material will be also experimentally charred to test preservation impact on shape. The seeds will be reconstructed using micro 3D photogrammetry and will then be subjected to 3D GMM and surface texture analyses. The data obtained will be fed into purposely developed ML algorithms to classify and match shape and agricultural data. iShape3DSeed will provide thus a new means to identify agricultural management regimes in archaeological seed assemblages solely using the full shape of cereal seeds, pushing the frontiers of archaeobotany.

Mots clés : archaeobotany, agricultural management, geometric morphometrics, machine learning, minoan

Participants :
- Institut Català d'Arqueologia Clàssica (Espagne) — Coordinator, beneficiary, Recherche, subvention : 172932.48 €
Projet InnovaXN (Horizon 2020, appel à projets 2018)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

Researchers trained in advanced materials characterisation and capable of exploiting the facilties available at research infrastructures (RIs) are needed to bridge the knowledge gap between Europe’s world-leading RIs and industry. These select individuals should be highly-skilled entrepreneurs and communicators in addition to being innovative researchers. The InnovaXN programme aims to create such uniquely-skilled ambassadors to industry by recruiting and training 40 Early-Stage Researchers (ESRs) who will carry out research on projects defined and realised in close collaboration with industry. The programme will link the ESRF and ILL RIs with industry through 40 research projects. The subject of these projects will comprise multiple research fields from the vast range of subjects of interest to industry that could be enhanced by studies at the RIs such as drug discovery and health, energy materials, environmental science, food science and micro-electronics. InnovaXN will be a five-year programme. Research projects will be harvested through an open ideation and codesign procedure with industry. Two recruitment calls will be spaced twelve months apart. The duration of each ESR training period will typically be 36 months, with registration of the ESRs at Université Grenoble Alpes (UGA), a partner to the project, or other collaborating European universities. InnovaXN aims to recruit the best candidates from a worldwide student base. InnovaXN is open to students from a wide range of disciplines including chemistry, life sciences (biochemistry, medicine), materials science, engineering, environmental science and physics. The ESRs will receive employment contracts at the ESRF or the ILL (each will recruit half of the students). The ESRs will be hosted in Grenoble at the EPN-Campus site for most of the duration of their research but for a period of secondment to the site of the industry partner of at least three months to gain experience of working in industry.

Mots clés : innovation, industry, research infrastructure, synchrotron x rays, neutrons

Participants :
- European synchrotron radiation facility (France) — Coordinator, beneficiary, Recherche, subvention : 3254400.0 €
Projet EVERYDAYNIGHT (Horizon 2020, appel à projets 2016)
Action : European Researchers' Night
Statut du projet : CLOSED

Researchers’ Night again in Poznan! EVERYDAYNIGHT! Wielkopolska Researchers’ Night welcomes - Let the experience of the Night last every day! Come and see how research influences your every-day life! Reveal the interdisciplinary nature of science and learn how different scientific fields complement each other, making our life better. Join speed dating with our researchers, defeat them in quizzes and win a badge of the young scientist! See how future school will look like, reveal how environment interacts with robotics and sport. Meet MC fellows and convince yourself that career in science is a great adventure! Feel the atmosphere of NASA laboratory. Take part in “Mamma Mia” show - sing and dance with researchers, meet exoskeletons and discover the economics of joking. Feel like doing some sport? Come and play fitball, tennis or basketball with researchers. These and many other attractions are waiting for you to reveal your passion for science and convince you that researchers are just ordinary people with an extraordinary job and various hobbies. EVERYDAYNIGHT is a continuation of the Researchers’ Night projects of the past nine years, which were highly successful gathering in 2015 app. 59 000 participants. The project builds on last years’ experiences and aims at strengthening efforts to bringing researchers closer to the public at large, increase the awareness of research, by supporting the public recognition of researchers, clearly showing the impact of researchers’ work on society and every-day life. Activities during the Night on 30 September 2016 and 29 September 2017 will focus on public at large and will have hassle-free and festive character, being a valid alternative to "traditional Friday night activities". Those activities will offer a direct contact between researchers and public, combine fun elements (edutainment), envisage linking together Nights organised in different cities in Poland and ensure active involvement of both researchers and audience.

Mots clés : researchers, poland, pozna, science and fun, edutainment

Participants :
- Poznań University of Technology (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 46600.0 €
- Adam Mickiewicz University in Poznań (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 24125.0 €
- Poznań University of Economics and Business (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 10500.0 €
- Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 7907.5 €
- University of Life Sciences in Poznań (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 24940.0 €
- Polish Academy of Sciences (Pologne) — Partner, beneficiary, Recherche, subvention : 19275.0 €
Projet DOROTHY (Horizon 2020, appel à projets 2020)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

Responding to the need to equip European societies with multi-disciplinary expertise to tackle future public health crises, DOROTHY COFUND will recruit, train and launch the careers of 25 excellent fellows through 36-month fellowships (18 months overseas and 18 months in Ireland). Postdoctoral researchers from all disciplines will be eligible (e.g. epidemiology, engineering of materials, diagnostic tools, psychology, economics, social history, education, sociology, political science, medical and health humanities and philosophy), as long as their research projects fall within the remit of public-health crises. DOROTHY's goals are: -Support fellows’ career development, through excellent training and supervision and mentoring, and prepare them for future career opportunities by means of the exceptional skills and timely and topical experience that will be gained through these fellowships. - Create a critical mass of well-networked experts, from all disciplinary areas, who will be fully able to engage with the Irish and EU innovation ecosystem, through the set-up of an innovative multidisciplinary research and training platform. These individuals will be trained to tackle future public-health crises in ways that will lead to positive societal impact. -Promote the dissemination and communication of impactful research beyond traditional academic channels, targeting policymakers and population at large , with the objective of contributing to resourceful and resilient societies. - Pioneer an innovative multidisciplinary approach to the way public health crises are understood and tackled. As they are broad-ranging and complex phenomena, with multi-issue implications, solutions cannot prescind from the cooperation between disciplines, sectors and research areas. DOROTHY, which shows the feasibility of that, aims to become a replicable template for multidisciplinary, international and intersectoral training approaches.

Mots clés : public health crises, global health, interdisciplinary health, health communication, public health policy, environmental health

Participants :
- Higher Education Authority (Irlande) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 2758500.0 €
Projet REHEAL (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Rethinking the Health Experience and Active Lifestyles of Chinese Students Rising immigration rates into the European Union (EU) has brought increased cultural and linguistic diversity, but also increasing levels of inequalities and the associated challenges of their alleviation. The promotion of physical activity as part of a healthy lifestyle, particularly for the young, is an important part of the European policy to address health inequalities. Minority ethnic youth are amongst those groups with the lowest levels of physical activity, and are identified as a ‘risk’ group in ‘problem-orientated’, ‘deficit’ (and Western) approaches. Chinese youth is a specific group within this physically inactive category, and yet have rarely been the focus of research or policy initiatives. Although described by teachers as ‘model minorities’ - hardworking high achievers - in physical education, health and physical activity (PEHPA), little is known about Chinese youth’s physical activity involvement, or what might represent best practice in PEHPA promotion for this group. Using innovative, participatory methodologies, this research will map the influences on Chinese youth’s needs, meanings, and experiences in PEHPA, create strength-based, new knowledge that goes beyond existing ‘deficit’ approaches to inform strategies to promote their health and physical activity, and develop best practice guidelines for schools and communities. The training through research will be within the Diversity, Equity and Inclusion (DEI) research centre at Leeds Beckett University, one of the largest groupings of internationally renowned experts in the field, with supervision from the Centre head whose research programme provides an ideal match to the training requirements of the proposed research. The training will specifically extend the applicant’s theoretical expertise in contemporary theorising of ethnicity, race, intersectionality and inclusion/promotion; develop expertise in innovative research

Mots clés : minority ethnic, active lifestyle, health, physical activity, chinese youth, race, gender, intersectionality, participatory methodologies, eurocentric, strengths based

Participants :
- Leeds Beckett University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet Extending MEDT (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Revealing why and how reactions take place is the essential goal for fundamental investigations of chemical reactivity. The breaking and forming of chemical bonds in a chemical reaction is directly associated with the depletion and accumulation of electron density between atoms. In the recently proposed Molecular Electron Density Theory (MEDT), the origin of chemical reactivity is deduced directly from the changes of electron density, as analysed by well-established quantum-chemical tools. This contrasts with typical approaches (e.g., molecular-orbital theory), where chemical reactivity is inferred, indirectly, from mathematical entities that are not directly associated with changes in electron density. Building on the new chemical insights obtained by the application of MEDT to pericyclic reactions and 1,3-dipolar cycloaddition reactions, the principle goals of this project are (a) to develop and extend MEDT to additional electron-density-based quantum chemical tools and more accurate types of computations and (b) to convince physical and organic chemists that MEDT is preferable to traditional methods for the rationalisation of chemical reactivity. To achieve the second goal, we will revisit traditional chemical concepts, many of which were proposed even before the development of modern quantum chemistry, and assess whether they are consistent with observed electron density changes. We will also explore applications of MEDT, both to traditional textbook reactions in organic chemistry and to the intricate reaction pathways associated with prebiotic chemistry, especially the prebiotic syntheses of imidazole, nucleotides, and other touchstone prebiotic molecules. By these means, we shall establish MEDT as a new paradigm for interpreting chemical reactivity, based on the experimentally observable electron density.

Mots clés : electronic structure, molecular electron density, chemical reactivity, reaction mechanisms, selectivity, conceptual chemistry

Participants :
- University of Valencia (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 232497.6 €
- McMaster University (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €