Projet ARCH (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

ARCH is a network of highly qualified experts in experimental hematology created to decipher the causal relationship between the physiological changes in the hematopoietic system during lifespan and the parallel occurrence of specific age-related hematological diseases (pediatric, adult, elderly), with the aim to develop novel targeted therapeutic treatments. ARCH research will integrate the results from complementary model systems (cell lines, mouse models, cells from leukemia patients) and it will deploy a large panel of cutting-edge technologies, such as single cells genomics, epigenomics, genome editing and organoid cultures, in a multi-faceted effort. The ARCH ambitious goal requires scientific and financial resources beyond the capability of a single group. To reach this goal, the ARCH network brings together 15 beneficiaries (12 academic, 2 SMEs and 1 private research institute) and 5 Partner organisations (3 academic, 1 SME and 1 patients’ association). Two European Consortia are present through their italian nodes. ARCH will recruit 15 ESRs that will be all enrolled in PhD programmes. Besides research laboratory work, the ARCH training programme includes scientific, technical and transferable skills courses that will provide ESRs with a solid scientific culture and with awareness of responsible research and innovation issues. This broad portfolio will enable ESRs to become leading academic, clinic or industrial players in the field. The unique combination of scientific excellence, quality of the educational programme and experience in translating basic research into exploitable results will provide ARCH with the real possibility of positively contributing to the enhancement of European competitiveness in the development of innovative, targeted drugs/treatments for hematological diseases, which currently represent a serious socio-economical problem for the European health care system.

Mots clés : hematopoiesis, cell differentiation, leukemia, cell signalling, genomics, bioinformatics, target identification, drugs, treatments for hematological diseases

Participants :
- Comitato maria letizia verga onlus (Italie) — Partner, organization partner, Autres, subvention : 0.0 €
- Tel Aviv University (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 263500.92 €
- Diagenode (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 256320.0 €
- Centre européen de recherche en biologie et en médecine (France) — Partner, beneficiary, Recherche, subvention : 274802.04 €
- Max Planck Society (Allemagne) — Partner, beneficiary, Recherche, subvention : 252788.4 €
- Spanish National Research Council (Espagne) — Partner, beneficiary, Recherche, subvention : 250904.88 €
- Flowmetric europe spa (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 261499.68 €
- Biomedical Research Foundation of the Academy of Athens (Grèce) — Partner, beneficiary, Recherche, subvention : 243017.64 €
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 274802.04 €
- University Medical Center Groningen (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 265619.88 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
- Autonomous University of Madrid (Espagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Milano-Bicocca (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 261499.68 €
- Becton Dickinson (United States) (Italie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- National Research Council (Italie) — Partner, organization partner, Recherche, subvention : 0.0 €
- Fondazione m. tettamanti e menottide marchi onlus (Italie) — Partner, beneficiary, Recherche, subvention : 261499.68 €
- Sapienza University of Rome (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 261499.68 €
- Institut Curie (France) — Partner, beneficiary, Recherche, subvention : 274802.04 €
- University of Veterinary Medicine Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 264207.24 €