Projet LOGIC LAB (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : SIGNED

A dysfunction of cells lining the inner walls of blood vessels, i.e. the endothelium, is the primary cause of many lifestyle related diseases. According to the WHO, those diseases accounted for 60% of all deaths worldwide in 2005. Tailor-made diagnostic tools for early and reliable identification of endothelial dysfunction are urgently needed both in fundamental research and clinical routine, respectively. The Marie Skłodowska-Curie action LOGIC LAB objects to develop and characterize innovative molecular logic gates that can be applied as advanced diagnostic tools for parallel analyte sensing in live mammalian cells. Thereby, providing a unique method to discover endothelial dysfunction and the onset of diseases much easier and earlier than so far. LOGIC LAB creates a multi-faceted and multi-sectoral research environment for the next generation of scientists in order to establish a novel type of molecular logic sensors that reliably operate in biological media – a crucial requirement for their application i.e. as rapid and easy-to-handle tools for intracellular diagnostics. With excellent cross-disciplinary scientific and complementary training provided in the network, we aim to educate highly-skilled young scientists in the fields of chemistry, physics and biology, who will significantly strengthen the international research community in the domain of molecular logic sensing. Thus, in the long term, LOGIC LAB aims to finally bridge the gap between lab bench and biological or medical practice. It is this gap, that so far prevents a wide-ranging use of existing molecular logic gates e.g. for the diagnosis of lifestyle-associated diseases.

Mots clés : molecular logic gates, biological sensing, molecular spectroscopy, microfluidics, metabolomics

Participants :
- MatTek (Slovakia) (Slovaquie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Friedrich Schiller University Jena (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- Dyomics gmbh (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Leibniz Association (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 505576.8 €
- Alexander schiller (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Cosmologic gmbh & cokg (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Leiden University (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 796859.64 €
- Dublin City University (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 549368.64 €
- Microfluidic ChipShop (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Sciclus gmbh & co. kg (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 252788.4 €
- Jagiellonian University (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 454957.2 €
- Slovak Academy of Sciences (Slovaquie) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 233246.88 €
- Mimetas (Netherlands) (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 265619.88 €
- Gdańsk University of Technology (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 227478.6 €
- Interscience bv (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €