Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CHRONUS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The CHRONUS project aims at providing new insights into the distribution of a complete set of anthropogenic actinides (233U, 236U, 237Np, 239Pu, 240Pu, 241Pu, 242Pu, 244Pu) in the Baltic Sea using the ultra-sensitive Accelerator Mass Spectrometry (AMS) technique, representing a needful step forward in the field of Applied Nuclear Physics to address environmental problems. The Baltic Sea is one of the most contaminated marine environments in the world regarding radioactive materials, being exposed by multiple contamination sources in such a way that understanding the different inputs and distribution patterns of the radioactive contaminants has become a major challenge. Specifically, there are still many open questions regarding the distribution of the actinide fallout from the Chernobyl accident in 1986. Understanding the distribution of radionuclides in this marine environment may be crucial for many environmental applications as well as future radioactivity emergencies. This action would include the analysis of the extremely low abundance 233U and 244Pu, providing novel tools to identify local contamination inputs from the baseline radioactivity levels imposed by the atmospheric nuclear weapon tests (1945-1980). Sediment cores collected from stations covering the whole Baltic Sea will be used to this end. Novel sample preparation and AMS measurement techniques will be developed to perform all those analyses using the compact 1MV AMS system at the Centro Nacional de Aceleradores (CNA), an international centre for accelerator science and technology of the host institution (University of Seville, USE, Spain). This action will involve the integration of the researcher, Dr. Mercedes López-Lora, at the Department of Atomic, Molecular and Nuclear Physics (FAMN) and within the very active and multidisciplinary group of Applied Nuclear Physics (GFNA) at the USE, under the supervision of Dr. Elena Chamizo, a high-recognised expert in AMS techniques and applications.

Mots clés : accelerator mass spectrometry ams actinides baltic sea sediments uranium 236 uranium 233 plutonium neptunium 237 environmental radiotracers chernobyl accident radioactive contamination

Participants :
- Université de Séville (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet JREACT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The JREACT Project wants to provide a non-confessional model for teaching about religions in schools, i.e. Religious Education (RE), that eschews ethnocentrism and promotes critically self-reflection, diversity and inclusiveness. It does so by engaging the case-study of RE in Japan from the point of view of the academic Study of Religion (SoR). In the last 20 years debates and developments on RE and Intercultural/Citizenship Education (ICE) have increasingly intersected, especially in Europe. However, the SoR has since long criticized the modern, Christian and ethnocentric biases inherent in the concept of “religion”, thus highlighting an intrinsic intercultural weaknesses in RE. Nonetheless, International/European research aimed at the creation of SoR-based RE didactics still lacks a thorough engagement with non-western contexts. This hinders the creation of a full-fledged intercultural and inclusive RE. JREACT want thus to improve European SoR-based RE through a comparative analysis with the Japanese case. The reasons to choose Japan are its peculiar religious situation (which often eludes Eurocentric views on religions), its long scientific tradition (for and non-European country) in the modern study of religion, and an ongoing debate on the role of RE in schools. It will contextually compare Japanese and European SoR-based RE theories and methods, looking for unnoticed biases, mutually reinforcing points, uncharted areas and contrasting points. From this it will elaborate innovative concepts and methods for RE and articulate them into guidelines. Its interdisciplinary approach combines SoR, Didactics, Anthropology of Education and ICE. JREACT will establish my position as an expert in intersecting fields: comparative RE; society & religion in contemporary Japan, theoretical issue in SoR, Didactics and ICE. At the societal level, it will innovate the debate and the practices concerning RE in European schools from the perspective of critical ICE.

Mots clés : study of religions study of religions based non confessional religious education in europe japanese religious education subject didactics intercultural education critical postcolonial approaches

Participants :
- Université de Rome « La Sapienza » (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 384915.24 €
- Université Gottfried-Wilhelm-Leibniz de Hanovre (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Tokyo (Japon) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet GLUCHIRAL (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Celiac disease (CD) is a systemic autoimmune disorder triggered by gluten consumption in genetically predisposed individuals, affecting a substantial portion of the European population (1.4%). A significant number of CD cases remain undiagnosed (75%), leading to untreated disease and its associated symptoms. These range from immediate gastrointestinal and extra-intestinal distress to long-term complications such as osteoporosis, infertility, and cancer, among others, placing substantial strain on society and healthcare systems. As the primary treatment for CD remains a strict gluten-free diet, there is a pressing need for innovative approaches to alleviate the burden of inadvertent gluten exposure. This proposal aims to investigate the molecular mechanisms governing the transport of gluten immunogenic peptides (GIP) across the small intestine and to develop a chiral-based strategy for the design of enantiomeric peptides that can inhibit GIP toxicity and immunogenicity. Our objectives are: 1) To develop a focused library of enantiomeric peptide inhibitors of GIP that could be used as novel therapeutic agents for CD. 2) To elucidate the molecular mechanisms of GIP transport and immunogenicity across the small intestine using GIP enantiomers as probes. 3) To establish a liquid chromatography–mass spectrometry (LC-MS) assay for GIP quantitation in biological samples as a novel diagnostic tool for assessing gut permeability in CD patients. The successful accomplishment of these objectives will provide valuable insights into GIP activity and transport within intestinal epithelium and immune cells. Moreover, it offers the potential to identify novel peptide-based therapeutics against GIP, with the possibility of further commercialization. Lastly, the success of this proposal carries the critical importance of raising awareness about CD and pathologies associated with gluten consumption, addressing the alarming rate of undiagnosed cases within the European population.

Mots clés : celiac disease, gluten immunogenic peptides, gut diagnostic tools

Participants :
- Université de Séville (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226441.2 €
- Biomedal (Spain) (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet UNICOSMOS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The recent observation of many quantum correlated phases, including superconductivity and correlated insulating states, in twisted bilayers of 2D materials, has sparked tremendous interest and boosted intense research activity to understand these phases. The ability of robustly engineering quantum states of matter with few tunable experimental knobs, e.g. the twist angle between the two 2D materials, represents a major breakthrough of these so-called moiré materials, which started the new field of twistronics. In particular, moiré materials made from transition metal dichalcogenides (TMDs), have gained significant momentum as a novel and robust platform for simulating quantum phases of matter on emergent 2D lattices. While it is widely accepted that these quantum phases are driven by enhanced electron-electron interactions in moiré materials, the quantum nature of many correlated phases is still poorly understood. Theoretical and computational first principles methods can be extremely powerful in helping to unravel the experimental signatures of the different quantum phases and also predict new ones. However, standard methods, like density functional theory, are computationally too costly for moiré systems (for which typical unit cells contain thousands of atoms) and generally unable to tackle the challenges posed by strongly correlated materials. A new approach is therefore required.  In this fellowship, I will develop an efficient multi-scale framework, involving different theoretical and computational methods, for studying quantum phases of TMDs moiré superlattices. Specifically, I will combine classical force field calculations, machine-learning based tight-binding methods and many-body methods to overcome the limitations of conventional first-principles approaches while maintaining their predictive power.  This framework will allow us to shed light on the nature of the quantum phases hosted in moiré materials, which can be harnessed in future technologies.

Mots clés : 2d materials, moir superlattices, tight binding, machine learning, density functional theory

Participants :
- Université de Trieste (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet SolarPlas (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Atmospheric plasma (AP) is envisioned as a revolutionary green technology for wastewater treatment as compared to conventional biological and advanced oxidation processes due to its robust performance in degrading recalcitrant emerging contaminants and micropollutants. AP powered by DC, AC, or pulsed power sources, in the air or in contact with water produces a multitude of reactive species able to attack and ultimately mineralize the contaminants dissolved in water. Salient features of this novel technology include operation at NTP, flexibility, rapid startup, in situ generation of reactive species (e.g. H2O2, O3, ˙OH, ˙NO, NO2˙) without chemical addition which makes it a futuristic green technology. However, an inherent disadvantage is its high energy cost which hinders its large scale application; only a few examples of treatment of real water samples are indeed reported. Previous research on AP application for emerging contaminant removal also lacks in designing and selecting a plasma discharge capable of treating surfactant and non-surfactant types of emerging contaminants efficiently. Therefore the objectives of this proposal include the development and testing of a standalone solar-powered dual discharge plasma reactor (SolarPlas) for sustainable wastewater treatment targeting efficient removal of emerging contaminants of surfactant and non-surfactant nature. The dual discharge will consist of 1) plasma in contact with liquid at the gas-liquid interface for destroying surfactant type of emerging contaminants while 2) plasma discharge at the bottom of the reactor diffused through the air bubbling will effectively degrade non-surfactant type of emerging contaminants from Hospital wastewater and landfill leachate. The main outcome of the project will be in the form of an efficient solar-powered AP reactor (SolarPlas) for wastewater treatment with defined energy efficiency for the treatment of various types of wastewater matrices (municipal, industrial etc.).

Mots clés : atmospheric plasma treatment, emerging contaminants treatment, micropollutants, sustainable wastewater treatment, corona discharge, point of use treatment, industrial pollution control

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 207187.2 €
- NED University of Engineering and Technology (Pakistan) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MitoRescue (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Invasive alien species (IAS) are the cause of enormous socio-economic and biodiversity loss across the world. In the context of climate change and increased pollution, IAS are often more adaptive than native species, capable of adjusting their phenology in accordance with climatic changes, facilitating their invasion. It has been recently suggested that “rapid evolution” (allowing quickly adaption and avoiding extinction due to maladaptation), is the cause of the increased invasive capacity of IAS. In MitoRescue I take this concept one step further, and I hypothesize that mitochondria, being exquisitely sensitive to environmental stress and with a highly mutagenic DNA, are key organelles involved in rapid evolution resulting in “evolutionary rescue”. I will study the combined impact of pollutants and increased temperature on an ancestral and an invasive (recently established) population of the European Green Crab, an extremely prolific invader. The study involves both field and laboratory approaches, from the organelle to the whole-organism. It merges the fields of toxicology, physiology, evolutionary and molecular biology to provide a highly multidisciplinary and integrative perspective. The final objective of this research subject is to predict future invasion scenarios, identify novel targets to control IAS proliferation and improve management and risk assessments of IAS in Europe and worldwide. With MitoRescue I will use a state-of-the-art training in assessing mitochondrial plasticity to consolidate my career in Europe and compile the necessary data to establish a research subject new to the ERA with great translational impact. In the long-term, this research will promote “restoring Europe’s biodiversity”, which is one of the four current key strategic orientations for EU’s R&I. It will contribute as well to the European Green Deal Initiatives and the EU Biodiversity Strategy for 2030 by addressing IAS socio-economical management in a thermally changing world.

Mots clés : invasive alien species, evolutionary rescue, rapid evolution, mitochondria

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 298734.72 €
- Université Griffith (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet REPAIR (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Increasing aridity due to climate change is a major factor that has dramatically altered the structure of Patagonian drylands, which has resulted in changes in ecosystem structure and functioning, e.g., a loss of vegetation, biodiversity, and soil erosion. Such changes ultimately lead to a loss of resilience, the system's ability to resist and recover from external disturbances while retaining the same function and structure. Although our ability to monitor resilience at large scales has been accelerated by remote sensing data and techniques, greater insights into the role of certain biotic and abiotic variables (e.g., species richness or soil carbon) on resilience at the local scale, would create new opportunities to support sustainable management to increase resilience across Patagonia. In this project, I will bridge these scales, by linking remote sensing time series data and a unique database (MARAS) of continuous field observations across Patagonian rangelands (managed by Argentinian partners). Specifically, I will 1) characterize changes in resilience in response to increasing aridity based on remote sensing between 2000 - 2025, 2) collect and analyze ground observations, and 3) investigate drivers of resilience dynamics across Patagonian rangelands integrating the remote sensing-based resilience and field data. To achieve this, I will use state-of-the-art methods in ecology and data science (e.g., time series analysis and machine learning) to deliver a better understanding of which environmental variables impact resilience in what way. I will carry out the research at the Complutense University of Madrid (Spain) at the Department of Biodiversity, Ecology and Evolution, under the guidance of Dr. Miguel Berdugo; and I will undertake a secondment with the Soil Conservation research group at the National University of Luján (Argentina) under the supervision of Prof. Dr. Juan José Gaitán.

Mots clés : resilience, vegetation dynamics, drylands, field observations, climate change, aridity

Participants :
- Université complutense de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
- National University of Luján (Argentine) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet RISK-MATTER (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Psychotic disorders rank among the top 25 global causes of disability, impacting individuals, their families, and society. Much of this burden stems from early onset and poor clinical outcomes. While approximately 30% of individuals experience persistent symptoms, illness trajectories following a first psychotic episode vary widely and remain poorly understood. Cumulative genetic and environmental risk exposures and underlying white matter (WM) microstructure abnormalities have been associated with clinical outcomes during the first few years following psychosis onset. Still, it remains unexplored how different combinations of risk exposures are linked via WM microstructure with short- and long-term psychosis outcomes. Thus, RISK-MATTER aims to identify biologically and clinically meaningful subgroups of individuals with recent-onset psychosis based on their different genetic and environmental risk profiles by employing advanced clustering approaches. I will assess whether stratifying participants into these more similar subgroups enhances the effectiveness of supervised machine learning models that utilize WM microstructure and baseline clinical features to predict traditional one-year clinical outcomes. Yet, traditional retrospective assessments to evaluate clinical outcomes are prone to memory and assessor bias. Hence, I will further re-contact a subset of individuals up to eight years after psychosis onset to collect traditional and smartphone-based assessments to determine whether my models’ predictive accuracy is robust when evaluating longer-term and real-life outcomes. During this project, I will build expertise in diffusion-weighted imaging, unsupervised machine learning, and smartphone-based assessments, mentored by Prof. Pasternak (Harvard Medical School) and Prof. Koutsouleris (Ludwig-Maximilian-University). These skills will bolster my academic profile as a neuroscientific psychologist and facilitate my growth as an independent research group leader.

Mots clés : recent onset psychosis environmental risk factors, genetic risk, white matter integrity, machine learning, clustering, smart phone based assessment

Participants :
- Université Louis-et-Maximilien de Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 220966.8 €
- The general hospital corporation (Etats-Unis) — Partner, associated partner, Autres, subvention : 0.0 €
Projet e-AlcToRad (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Transition metal-catalysed cross-coupling reactions are considered landmark achievements in organic synthesis; thus, a modern organic chemist’s toolbox is filled with methods building C(sp2)-C(sp2) bonds. However, the myriad of tetrahedral carbon atoms in organic molecules alongside the ever-growing interest in drug discovery and development to access the tree-dimensional chemical space has encouraged chemists to develop cross-couplings that involve C(sp3) atoms. Despite their ubiquitous nature, the most available sources of functionalised C(sp3) atoms, alcohols, are underutilised in cross-coupling reactions due to the difficulty associated with the C(sp3)-O cleavage step. Their mainstream adaptation for cross-coupling reactions would unlock a previously untapped chemical space by virtue of their structural diversity, stability, and convenience. Furthermore, shifting the focus from halides to more environmentally benign alcohols offers a green and sustainable future by minimising manufacturing costs and toxic waste. Therefore, the overarching goal of this proposed research programme is to devise new, generally applicable, and modular methodologies in organic chemistry to address the long-standing challenge of alkyl radical generation from alcohols; thus, making the C(sp3)-OH bond a mainstream radical cross-coupling handle. Using transition metal catalysis, downstream application of these radicals would construct C(sp3)-C(sp3), C(sp3)-C(sp2), and C(sp3)-heteroatom bonds furnishing complex structures from ubiquitous precursors. In order to harness the potential of native alcohols, and to achieve the aims of this proposal, the outgoing phase of this fellowship would take place in Prof. Phil S. Baran’s laboratory at Scripps Research, La Jolla, USA. During the third, final year, the incoming phase would take place at Dr. Josep Cornella’s laboratory at Max-Planck-Institut, Mülheim an der Ruhr, Germany.

Mots clés : radical chemistry, alcohol activation, electrosynthesis, transition metal catalysis

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 265647.84 €
- Institut de recherche Scripps (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €