Projet STOP SPREAD BAD BUGS (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks - Industrial Doctorates
Panel : Life Sciences
Statut du projet : SIGNED

STOP SPREAD BAD BUGS is a new multi-disciplinary research/training consortium built to combat the alarming problem of global antimicrobial resistance. Multi-drug resistance (MDR) in bacteria is becoming increasingly common thus urgently calling for alternative approaches to develop and implement novel antibiotics. We envision a definitive solution that will require a paradigm shift. Its foundation shall be the training of a new generation of future 15 Early Stage Researchers (ESRs) by world-renowned experts in the field of drug development, infectiology, immunology and pharmacology. A unique state-of the-art teaching/training pipeline shall be developed across 7 academic and 5 SME partners with complementary expertise in the development and testing of novel approaches to antimicrobial therapy in humans. We shall establish knowledge and expertise on carbohydrate and protein chemistry for the discovery of new drug candidates, while characterizing the underlying mechanism of existing compounds for treatment of microbial infections. Computational modelling shall optimize the interactions of the novel entities with selected pathogens. A range of infection models allows partners to simultaneously determine compound efficacy in pre-clinical settings and investigate the potential effects of the novel antimicrobials on host tissues. State-of-the-art imaging tools will be applied to track the bacteria and novel compounds in these test systems. Uniquely, the pipeline will also determine the pharmacokinetics, and the effects of compounds on host microbiota and host immunity. Understanding the mechanisms of action of the novel antimicrobials shall provide insights into new antimicrobial mechanisms, which may be further exploited in spin-off projects. This approach means that the STOP SPREAD BAD BUGS consortium will deliver uniquely trained, multi- and interdisciplinary ESRs that will take the continuing fight against global MDR safely into the future.

Mots clés : antimicrobial resistance novel antibiotic solutions antimicrobial peptides non digestible oligosaccharides computational modelling pharmacokinetics mucosal immunology microbiota

Participants :
- Université de Sienne (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Inbiose (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 262620.0 €
- Aquilon pharmaceuticals sa (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 175080.0 €
- Université de Marbourg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 130269.6 €
- Université autonome de Barcelone (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Hylomorph ag (Suisse) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 446439.6 €
- Anitom (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 131310.0 €
- Université de médecine de Vienne (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Medres-medical research gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 130269.6 €
- Setlance srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 408325.96 €
- Tissuegnostics gmbh (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 405496.8 €
- Italian Institute of Technology (Italie) — Partner, beneficiary, Recherche, subvention : 126836.16 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Liège (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Érasme de Rotterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 548740.8 €
- Université d'Utrecht (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 411555.6 €
- Université de Glasgow (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Gand (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Trinity College (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 286488.0 €
- Institute of Agrifood Research and Technology (Espagne) — Partner, beneficiary, Autres, subvention : 251971.2 €
- Université de Stavanger (Norvège) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 256891.04 €