Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MultiAp-EMI (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Language-related challenges in English Medium Instruction (EMI) affect academic outcomes in disciplinary courses in higher education, as students who use English as a second language are often found to struggle with discipline-specific discourse. Although the need for a more integrated approach to content and language in EMI and the usefulness of multilingual and multimodal practices are recognized in research, there has been little exploration of their impact on learning as perceived by students. More specifically, the patterns of the use of various linguistic and semiotic resources and their role in the moment-by-moment construction of subject-specific knowledge remain underexplored. This project seeks to investigate the use of multilingual and multimodal resources by EMI instructors across disciplines and their impact on students’ learning within the classroom. It aims to refine the concept of bi/multilingual disciplinary literacies, developed in a recent COST Action, CLILNetLE, by incorporating perspectives from tertiary-level EMI content specialists and students. To this end, the project will employ an innovative combination of Multimodal Conversation Analysis, Epistemic Network Analysis, and the Idiodynamic Method, which allows the exploration of interactional details of teaching, the constellations of linguistic and multimodal resources, and students’ self-assessed understanding of discipline-specific content. The project outcomes will contribute to EMI teacher training, inform educational language policies, and promote inclusive teaching practices that address the needs of EMI students from diverse backgrounds—all increasingly important as EMI programs expand across Europe and beyond.

Mots clés : content and language integrated learning english medium instruction disciplinary literacies multimodality translanguaging transsemiotics

Participants :
- Université de Jyväskylä (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226276.8 €
Projet Super-HIPPO (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Main challenge of fighting with the HIV is to eliminate the latent viral reservoir from the body. This reservoir is resistant to antiretroviral drug therapy and can cause viral rebound if the treatment is stopped. The removal of the reservoir enables HIV eradication, is urgently desired in HIV-AIDS research. For this purpose, a strategy called “kick and kill” was proposed, based on the hypothesis that activation of latent HIV (“kick”) leads to cell death (“kill”) by physical damage and/or immune activation. However, in clinical tests “kill” process was found to be not enough to reach HIV eradication.  To eradicate HIV from the body, my work has recently suggested a new strategy called “lock-in and apoptosis” instead of “kick and kill”. In development of this strategy, non-natural derivative of inositol hexaphosphate (IP6) named as L-HIPPO was designed based on the fact that the MA domain of Pr55gag which mediates membrane binding through its interaction with inositol phospholipid PIP2 in the host membrane. L-HIPPO was administrated to HIV infected HeLa cells as complex with a carrier α-CDE and suppressed membrane localization of HIV-1 Gag protein and induced strong apoptosis of the host cell containing the latent viruses. In contrast, α-CDE-L-HIPPO induced less apoptosis on T cell line. Besides, the complex of α-CDE-L-HIPPO is inapplicable for oral use. Toward this end, new L-HIPPO derivative with alternative carrier is required.  An ultimate goal of this work is to develop new L-HIPPO derivative (Super-HIPPO) with more potent and efficient activities. My objectives to reach this goal are (1) to synthesize new L-HIPPO derivatives and alternative carriers, (2) to evaluate their activities, (3) to repeat design, synthesis and biological evaluation, if the activities are not enough, (4) to confirm the binding mode of MA-compound, and (5) to achieve personal development and career advancement by performing this study.

Mots clés : inositol hexaphosphate, nanoparticles, hiv 1, matrix protein, and x ray crystallography

Participants :
- Izmir Kâtip Çelebi University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 148478.4 €
Projet ReGreenConstitution (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Future generations and youth inherit at least two debts (with incoming crises attached). The first incoming crisis results from the accumulation of greenhouse gases in the atmosphere. This climate crisis requires taking steps to mitigate it and adapt to its consequences. Those mitigation and adaptation efforts have even been quantified. The global investment gap for climate change mitigation is estimated at $380-680 trillion annually. Moreover, a further $60-100 trillion must be additionally invested into climate change adaptation measures (annually!). Those two investment gaps need to be filled with private and public investments. The second incoming crisis results from the constant accumulation (up to now) of public debt - the sovereign debt crisis. Future generations will live in democratic states overburdened with debt – and current youth already does. Most democratic states already have debts of 60%, 100%, 150%, or even more of their annual gross domestic product (GDP).  However, this mixture of those two incoming crises with massive funding needs for climate change mitigation and adaptation measures significantly limits future generations in their activities and their (financial) options. The same limitations affect governments in jurisdictions where future generations will live. Meanwhile, climate change and environmental damage are legacies of our civilisation. Tackling those challenges requires undertaking financial efforts both at a global level and by particular states. ReGreenConstition's objective is to verify whether citizens could help in overcoming this zugzwang through new types of bonds (Green, Social, Sustainability and Sustainability-Linked Bonds). By combining different research disciplines (law, economics) and relying on a deep interdisciplinary methodology, the project will allow designing new policy and legal frameworks facilitating citizens to “vote” with their savings on climate change mitigation and adaptation measures.

Mots clés : green bonds, sustainability, climate change

Participants :
- Université de Vilnius (Lituanie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196976.16 €
Projet REGULINC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

One of the top ten tumors that occurs worldwide most commonly is renal cell carcinoma (RCC) and its incidence is increasing. Regulatory T cells (Tregs), expressing transcription factor FOXP3, play a critical role in the suppression of inflammatory responses maintenance of self-tolerance. However, within the TME, Tregs contribute to tumor development and progression by reducing antitumor immune responses and promoting tumor growth. The dysregulation of specific lncRNAs has been correlated with the prognostic outcomes of patients with RCC, whereas the lncRNA dysregylation in tumor infiltrating lymphocytes is unclear. The overall objective of REGULINC is to increase our understanding of the role of both known and novel lincRNAs in governing the function of regulatory T cells (Tregs) present in the tumor microenvironment (TME) of RCC. This study will identify for the first time the TILs-specific lincRNAs – with a focus on Tregs, and their role in Treg interactions with other immune cells in RCC samples. REGULINC will probe into the role of novel lincRNAs in the stability of Tregs and their cell-suppressive capacity, and ascertain if modulation of selected lincRNAs could result in enhanced immune response by TILs in the TME. The project will gain new mechanistic understanding of how lincRNA network defines Tregs activity in TME of RCC. It will also develop novel tools for therapeutic intervention through specifically targeting immune-suppressive Tregs to boost immune response in the TME of RCC.

Mots clés : long non coding rna, tregs, tils, crispr

Participants :
- Université de Turku (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226276.8 €
Projet MitoEpigeNeAge (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The "MitoEpigeNeAge" research proposal seeks to uncover the molecular mechanisms of age-related neurodegeneration by focusing on the interplay between mitophagy, redox-regulated histone methylation, and neuronal death. Brain ageing is characterized by the accumulation of damaged mitochondria and epigenetic changes, leading to neurodegeneration. Mitophagy, the process that clears damaged mitochondria, declines with age but extends lifespan and offers neuroprotection when activated. However, its impact on the epigenome remains unclear. The project will utilize Caenorhabditis elegans due to its well-defined nervous system and evolutionary conservation of neuronal ageing mechanisms. Advanced technologies will analyse chromatin accessibility and gene expression in redox-sensitive neurons. Super-resolution imaging and optogenetics will allow precise manipulation of mitochondrial damage and mitophagy in live animals. Key objectives include: 1) Monitoring chromatin accessibility, histone methylation, and gene expression in wild-type and mitophagy-deficient worms; 2) Developing in vivo reporters to track chromatin modifications during ageing and mitophagy induction; 3) Using optogenetics to assess the effects of mitochondrial damage on histone methylation in neurons; 4) Exploring if mitophagy-inducing interventions provide neuroprotection through changes in histone methylation linked to redox homeostasis; 5) Conducting a genetic screen to find mitophagy modulators that enhance mitochondrial quality control, histone methylation, and resistance to neurodegeneration. This project supports the researcher’s long-term goals and the MSCA's mission to promote innovative research. Its successful completion will greatly enhance understanding of age-related neuronal decline, with significant benefits for human health. The MSCA grant would be transformative, providing essential resources to advance the research and establish the researcher as a group leader in the ageing field.

Mots clés : ageing, mitophagy, epigenetic modifications, neurodegenerative diseases, oxidative stress, c elegans, mitochondria dynamics, chromatin remodelling, neuronal apoptosis, ageing pathways, aggregation

Participants :
- Université nationale et capodistrienne d'Athènes (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181423.68 €
Projet DESCRIPTOR (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The climate change has raised concerns about closing the carbon cycle by converting CO2 and renewable electricity to chemically stored energy in the form of fuels and commodity chemicals. Among these, long-chain hydrocarbons and alcohols are more attractive because of their high energy density and value. Recently, reconstructed oxide-derived Cu (OD-Cu) catalysts have shown the potential to produce multicarbon species at lower overpotentials. However, few simulations have addressed the formation mechanism of these compounds due to the complex dynamics of this system under high currents, and the exact site for the excellent OD-Cu catalytic performance remains to be discovered. The DESCRIPTOR project aims to obtain the first generation of CO2 electroreduction catalyst with useful faradaic efficiencies towards C3+ products by employing computational simulations based on Density Functional Theory (DFT) and augmented by Machine Learning techniques. Firstly, suitable structures for the OD-Cu materials will be obtained through large scale Molecular Dynamics simulations based on Machine Learning potentials, by screening the most common ensembles identified via graph theory. Secondly, the mechanism towards C3+ will be identified via jDFTx scheme, and descriptors of activity and selectivity will be found through dimensionality reduction techniques. Finally, to assess and compare to experimental work from our collaborators, the contribution of the solvent/electrolyte and effect of experimental parameters will be investigated via ab initio Molecular Dynamics and microkinetic modelling. The structures will be characterized via simulations of X-ray Photoelectron Spectroscopy, and Raman spectra, etc. In summary, the outcome of DESCRIPTOR will have a direct scientific and social impact, by increasing the basic knowledge on catalysis of achieving renewable fuel sources and improving EU’s industrial competitiveness within new technologies for CO2 reduction.

Mots clés : electrochemical carbon dioxide reduction reaction, machine learning potential based molecular dynamics, density functional theory, microkinetic modelling, ab initio molecular dynamics

Participants :
- Institute of Chemical Research of Catalonia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 175608.96 €
Projet nPKCInAction (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Integrins represent a family of cell adhesion receptors mediating cell interaction with the extracellular matrix ligands. Their ligand-binding activity is tightly regulated and, when defective, gives rise to thrombosis or inflammation and contributes to cancer progression. To date, the key steps of integrin activation in response to both extracellular and intracellular signals are well described, however, the counteracting processes resulting in receptor inactivation remain incompletely understood. The host laboratory has pioneered research in this area by screening to identify integrin inactivating proteins involved in neuronal disorders, cell migration and cancer. Although the novel subfamily of protein kinase C (nPKC) has emerged from these screens as putative integrin inhibitors, the role of these kinases in regulation of integrin-mediated signalling remains to be investigated. Benefiting from my strong methodological proficiency in protein kinase research and the host laboratory's extensive expertise in integrin biology in cancer, I aim to address the role of nPKCs in regulation of integrin activation from both mechanistic and pre-clinical points of view. I expect to identify new cancer relevant signalling nodes by executing mechanistic in vitro studies with specifically engineered kinase mutants, state-of-the art cancer cell biology and imaging, followed by in vivo pre-clinical cancer studies in cancer models and patient sample cohorts. The result of this innovative and interdisciplinary project will represent a valuable basis for potential design of drug targeting strategy and therapeutic intervention not only for treatment of cancer, but also of other diseases where nPKCs and integrins are implicated.

Mots clés : integrin regulation, protein kinase c, cancer signalling, cell migration, metastasis, phosphorylation, protein protein interaction

Participants :
- Université de Turku (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet PRO-TECTURE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Buildings are an essential part of human life, providing shelter, spaces for work, and hubs for community activities. However, conventional construction methods have a big negative impact on the environment. To achieve sustainability, alternative approaches using natural and environmentally friendly materials, such as wood, are being employed. Regenerative sustainability takes this a step further, not only by minimizing harm but also by creating a net positive impact on both the environment and the community. Engineered living materials (ELMs) represent an innovative frontier in realizing regenerative sustainability. The aim of PRO-TECTURE project is to develop more resilient and efficient ELMs by preconditioning living fungal cells (biofilm used as ELM) with abiotic stress. Previous research has shown that exposure to mild stress can trigger adaptive responses, preconditioning biological systems to be more resilient to future stressors. The PRO-TECTURE project will use stress preconditioning to enhance the resilience of ELMs, investigating the existence and duration of stress memory, as well as intraspecies stress communication through secreted molecules. Furthermore, given the ER’s background in biomedicine, the project will explore the possibility of interkingdom stress communication between pre-stressed fungi and human cells. By integrating ELMs into building practices, it is anticipated that these structures will not only minimize negative environmental impacts but also actively contribute to environmental restoration and enhance human well-being and health in the built environment. The PRO-TECTURE aims to stimulate innovation and facilitate knowledge transfer between the host and the ER by establishing a robust research network, organizing events, mentoring young researchers, and managing projects. Through this fellowship, the ER will gain advanced research and scientific skills, acquiring new competencies to achieve professional maturity and independence.


Participants :
- Université du Littoral (Slovénie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 182717.52 €
Projet TASTE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Recognising the importance of local cuisines and food landscapes, different international organisations and local governments have developed sustainable and gastronomic tourism projects under the premise that these types of activities contribute to promoting and branding destinations, maintaining and preserving local traditions, diversity, as well as taking advantage of and rewarding authenticity. Within the framework of these actions, the EU-funded TASTE project, proposes to ethnographically investigate, from a feminist perspective and a participatory methodology, the transformations of biocultural landscapes in coastal communities by generating knowledge and reflecting on the situation of traditional food systems and contemporary issues that impact on food sovereignty and social justice. Specifically, this research questions the link between food and wine tourism and traditional cuisines (understood as biosocial, historical and social reproduction processes), and their role in the protection and revitalisation of natural environments and cultural landscapes, with particular emphasis on recognising and emphasising the role of women in the conservation of these landscapes. To this end, it will explore how food is obtained, produced, prepared and consumed in local contexts, but also how it acquires meanings beyond culinary practices, in economic circuits and which are the different actors involved in these circuits. TASTE will be developed from the comparative analysis of two case studies: Lanzarote in the Canary Islands (Spain) and Ensenada, Baja California (Mexico). Two coastal regions, with arid-desert ecosystems, valued as tourist destinations for their landscape and biocultural heritage, as well as for the importance that leisure activities based on gastronomy (eco-gastronomy), wine production (food and wine routes) and and cultural heritage (heritage of different peoples, indigenous products and innovation).

Mots clés : biocultural heritage foodscape rural women gastronomic tourism traditional cuisines marine anthropology ecolog a pol tica feminista environmental affectivity gurmetisation

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €
Projet OCELL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Plants demonstrate remarkable adaptability to their environments, with temperature being a key factor in shaping their development. Understanding how plants perceive and respond to temperature fluctuations, particularly within non-stressful ranges (12–28ºC for Arabidopsis thaliana), is critical for optimizing plant fitness in the context of climate change. This project aims to unravel the mechanisms regulating temperature signaling in plants, focusing on how different organs, tissues, and cell types perceive and react to temperature changes. To address these challenges, we will first define and validate organ-specific gene regulatory networks (GRNs) in roots and shoots (WP1) and investigate how temperature variations in the aerial parts influence root behavior using a novel experimental system (WP2). Additionally, we will explore cell-type-specific GRNs through single-cell RNA sequencing of leaves under different temperature conditions (WP3). This interdisciplinary approach, supported by leading research institutions, is expected to provide new insights into plant temperature signaling. The findings will enhance our long-term capacity to predict and manipulate plant responses to climate change, with potential applications in agriculture and environmental sustainability. Furthermore, this project will significantly advance my expertise in plant molecular biology and bioinformatics, positioning me as a leader in plant-environment interactions .

Mots clés : thermomorphogenesis, climate change, gene regulatory networks, transcription factors, arabidopsis

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €