Projet FRESCO4NoPain (Horizon Europe, appel à projets 2023)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Chronic pain is a major societal and economic European burden, affects one in five adults, and its inadequate relief indicates a major unmet need for effective and mechanism-based non-pharmacological treatments. In FRESCO4NoPain, we propose that maladaptive brain oscillatory activity is associated with persistent pain, and that non-invasive brain neuromodulation may provide a novel treatment strategy. For this, mechanistic insight is needed. We see this as the perfect opportunity to unite world-leading experts in pain neuroscience to train 17 uniquely skilled Doctoral Candidates (DCs) who will become the future generation of pain scientists, fully equipped to address unmet challenges within chronic pain. The DCs will be integrated in a one-of-a-kind network-wide training infrastructure conducting frontline research on non-invasive brain stimulation that targets persistent pain based on i) preclinical studies of the relevant brain circuitries, ii) human studies of the involved mechanisms, and iii) clinical studies. Through FRESCO4NoPain, DCs will access a unique set of basic, experimental, and clinical disciplines in both academic and non-academic settings, tied together by synergistic collaborations across the network. An application-based and patient-oriented mindset will permeate the consortium via the active involvement of cutting-edge MedTech companies, knowledge actors and end-users. Only such a truly interdisciplinary and intersectoral approach can provide the necessary ecosystem to go beyond the state-of-the-art, promote disruptive thinking while developing new methods that overcome current technological barriers in the complex field of interdisciplinary pain neuroscience. FRESCO4NoPain will deliver on urgently needed non-pharmacological therapeutic concepts for chronic pain and build on fundamental scientific insights regarding the role of neuronal oscillations in the brain processing of pain, thereby potentially helping millions of people with chronic pain.

Mots clés : oscillatory signatures of pain functional connectivity changes and pain measures pain phase locked eeg rhythms top down control of pain cortical stimulation evidence for chronic pain

Participants :
- Université de Strasbourg (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Sync2brain gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Guger Technologies (Austria) (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 565387.2 €
- Université d'Aalborg (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1207152.0 €
- European pain federation efic (Belgique) — Partner, associated partner, Autres, subvention : 0.0 €
- Nexstim oy* (Finlande) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université technique de Munich (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 521078.4 €
- National Centre for the Replacement Refinement and Reduction of Animals in Research (Royaume-Uni) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université catholique de Louvain (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 787860.0 €
- University Hospital Heidelberg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 521078.4 €
- Université de Bristol (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Magventure a/s (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Neuroconn gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 565387.2 €
- Université de Versailles Saint-Quentin-en-Yvelines (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Sporedata ou (Estonie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Neuroelectrics (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Signifix b.v. (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Pain alliance europe (Belgique) — Partner, associated partner, Autres, subvention : 0.0 €