Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet OUTCROSS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

The purpose of this project is to apply operator theory to evolution equations in order to investigate fundamental properties of infinite dimensional dynamical systems with delay in state variables. Radoslaw Zawiski will pursue this goal within the Analysis Group at the School of Mathematics of the University of Leeds, under the supervision of Professor Partington. This interdisciplinary project searches for the answer to the question of necessary and sufficient conditions for admissibility and controllability of an infinite dimensional dynamical system. It also scrutinises weighted forms of admissibility and controllability for a delay system with problems involving the Dirichlet-type norms. With the above, this project goes beyond the state-of-the-art utilising innovative operator semigroup techniques, in particular Carleson embeddings involving sectorial measures and Toeplitz/Hankel operators, to obtain results in an underdeveloped area of state delayed infinite dimensional systems. Concurrently, this project crosses current frontiers in control theory of such systems, setting new level and worldwide standard by giving a great insight into the nature of evolution equations. By fulfilling its purpose, this project helps the European scientific community to maintain its leading role in operator theory and control theory, adding to this topic a relevant set of techniques specifically designed for state delayed evolution equations. In this respect, the fellowship supports Radoslaw Zawiski’s career development by providing him the right environment to attain the proposed research goals. Dr Zawiski will reach the full maturity as a leading researcher, with the solid background and possibilities to significantly contribute to the development of operator theory and control theory.

Mots clés : admissibility and controllability of infinite dimensional dynamical systems

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet C.A.R.E. OA (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The purpose of this project is to define how estrogen- and adenosine-receptors modulate each other in CD4+ T-cells during osteoarthritis (OA) development and how these pathways can be targeted for development of a new OA therapy. Alterations of the articular cartilage function and of the joint surrounding tissues lead to disease like OA. OA is a chronic invalidating disease with a large social impact. There is no cure and the treatments to manage symptoms, pharmacological and non-pharmacological therapies, are useful only for a limited time, after which joint replacement surgery is necessary. Women have increased risk of developing OA compared to men and epidemiology studies suggest that hormonal alterations play an important role in OA development. It is now widely recognized that inflammation is an important disease mechanism in OA pathogenesis. In particular CD4+ T cells have been identified as triggers of cartilage degradation in OA. CD4+ T cells express estrogen- and adenosine receptors, two important regulators of the immune system. In a recently published article, I showed that female mice lacking one of the adenosine receptors, A2A (A2AR), develop spontaneous OA with significantly milder disease symptoms compared to males suggesting a protective effect of female sex hormones on OA development. Interestingly, it has been shown that estrogens can modulate the expression of adenosine receptors. In this project, I am going to investigate the effect of pharmacological activation of estrogen receptors on the anti-inflammatory A2AR and the pro-inflammatory A2BR, and the involvement of their mutual interaction on CD4+ T cell proliferation, differentiation and migration ability. Moreover, the effect of combined A2B adenosine receptor blocking and estrogen treatment will be tested as a strategy for reducing pain and disease progression in an OA mouse model.

Mots clés : osteoarthritis, adenosine, estrogens, cd4  lymphocytes

Participants :
- University of Gothenburg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203852.16 €
Projet Cleansing Water (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The purpose of this project is to offer the first comprehensive study of the function of water and its relationship with baptism in the four most significant Old English poetry manuscripts: the Exeter Book, the Vercelli Book, the Junius XI and the Cotton Vitellius A XV. Analysis of a group of mainly poetic texts, selected on the basis of their references to baptism and water, will help determine how these topics are treated and developed in relation to salvation. The texts will also be studied with reference to their codicological context to reconsider the individual manuscripts as a whole and re-evaluate the criteria in the composition of the codices, and the different meaning these topics assume with regard to different contexts. Texts referencing water will be compared to show similarities and differences in the treatment of baptism, and linguistic patterns will be established. The study will lead to a better understanding of the Anglo-Saxons' culture; it will also help determine how, and to what extent, this vision has been assimilated and developed in contemporary European culture. The research results will be presented in a number of outputs, including conference papers, articles, a co-edited volume, and a monograph. The supervisor’s expertise both overlaps with, and complements the researcher’s skills, so that the project will be of mutual benefit at both individual and institutional level. The research activity and training at QUB will foster the researcher’s skills and promote her career by broadening her experience and improving her research techniques through contact with highly qualified scholars in a vibrant working environment. Active participation in seminars and conferences will allow her to engage in international collaboration, facilitating her entry into the international academic world. Her methods will benefit from the encounter with a dynamic community of medievalists, stimulating a multidisciplinary approach to current and future research.

Mots clés : water, baptism, religion, poetry, anglo saxon, manuscripts, old english

Participants :
- Queen's University Belfast (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet SwiftV2X (Horizon 2020, appel à projets 2020)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : SIGNED

The push for improved driving experience, including the ultimate goal of driverless vehicles, has fueled the development of Connected and Autonomous Vehicles (CAVs). Connectivity is an important enabler for CAVs, as it allows for autonomous vehicles to directly participate in the intelligent transportation system (ITS) and make collective intelligent decisions. 5G mobile networks play an important role in providing vehicular connectivity as mobile networks support mobility by default. However, the density of vehicles is high in urban areas that poses challenges for the support from mobile networks. Deploying ultra-dense small cells using millimetre wave (mmWave) communication is one promising solution since ultra-dense small cells deployment addresses the network capacity and mmWave addresses the interference arisen from the dense deployment. However, due to the relatively narrow footprint of a mmWave beam, using mmWave communication for fast moving vehicles requires careful allocation to utilise its potential and avoid selfishness in radio resource usage. This project sets an ambitious goal of designing smart and dynamic algorithms to manage mmWave beam allocations in CAV environments. The project first investigates solely on the mmWave beam allocations and proposes smart algorithm using both traditional optimisation technique for benchmarking and modern machine learning algorithms for practical operation. It then studies the radio resource allocation under multi radio access technologies (multiRATs) that is the likely deployment setup before the full mmWave small cell networks become practical in the future. Finally, our study is extended to vehicle-to-vehicle communication using mmWave that can support delay sensitive message exchanges and range extension. As experimentation needs expensive infrastructure, the foreseen secondments offer partners without infrastructure on their premises to test their design on other partners that possess the infrastructure.

Mots clés : vehicle to everything  v2x, connected and autonomous vehicles, machine learning, radio access technologies  rats, non orthogonal multiple access  noma

Participants :
- Bangkok University (Thaïlande) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- K3y (Bulgarie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 9200.0 €
- University of Technology Malaysia (Malaisie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Chemnitz University of Technology (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 92000.0 €
- Alexander Technological Educational Institute of Thessaloniki (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 87400.0 €
- University of Surrey (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 101200.0 €
Projet Media andConspiracy (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The question of truth receives much societal attention today as fake news, alternative facts and conspiracy theories seem everywhere. People speak in alarmed terms about filter bubbles, echo chambers, the distrust of official knowledge and the dawn of a post-truth era. The contemporary media landscape plays an important role in the rise and spread of these alternative forms of knowledge, but how is largely unknown. Wishing to delve deeper than current media hypes and moral panics allow for, I propose to ethnographically study the role of media in the everyday life of conspiracy theorists (CT) from a cultural sociological perspective by means of the following three research projects. 1) To study what media sources (TV-channels, newspapers, internet sites, blogs, Facebook pages/groups, etc) do CTs use to inform themselves about the world and why, I will ask them to keep a “media diary” for two weeks and reflect on that in a follow-up interview. 2) To study how CTs use media technologies in a world where search engines and social media algorithms filter the information people receive, I will ask them in an interview setting to perform several search queries online to show me they use or circumvent such filtering technologies. 3) to study how do CT’s read (interpret, appropriate and authenticate) media contents (texts and videos), I will conduct a photo/video elicitation interview to actively study how they do so and ask them to reflect on their practice. These three objectives together should illuminate the way people engage with media (technologies) in an era of information overload. Such insights are valuable not just for scholars interested in the topic itself, but speak more broadly to professionals in the field (e.g. journalists, policy makers, government officials, scientists, NGO’s and politicians) who have to deal with the broader distrust of official knowledge in Western European societies, especially as enacted by the internet.

Mots clés : new media studies, conspiracy theories, media usage, media readings

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €
Projet SODIS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The questions at the centre of the project Socially Distanced Solidarity: Far Right Recruitment and Enrolment During the COVID-19 Pandemic (SODIS) are how far right organisations have adapted recruitment strategies in time of crisis, namely the Covid-19 pandemic, how successful these strategies have been, and how pathways to joining have shifted as a result of the pandemic. The Covid-19 pandemic provides an unprecedented opportunity to examine changes in collective action and political protest, providing a natural experiment for policy intended to tackle radicalism. Due to lockdowns and partial lockdowns across the world, organisations have had to cancel protest activities and other events at the centre of many recruitment strategies; the ongoing threat of Covid-19 well into 2021 means that organisations must alter their strategies. The subsequent change, or lack-there-of, in recruitment numbers can have implications for counter-radicalisation strategies moving forward. SODIS relies on a modern research design focusing on various perspectives of organisation recruiters and new organisation members, and different national contexts, while taking advantage of this exceptional time in history. A quantitative online survey will lend to a better understanding of motives and attitudes of organisations members in four national contexts and to gain a better understanding of motives for joining organisations, qualitative interviews will be conducted in each country. SODIS will elucidate drivers of far right mobilisation and pathways to radicalisation, contributing to scholarship on social movements, collective action, and radicalisation studies. It will provide insight for practitioners working on countering radicalism and recruitment into such organisations, engaging with the conversation of how liberal and illiberal democracies deal with right-wing extremism .

Mots clés : far right, social movements, hate groups, radicalism, recruitment, pathways, protest, europe, covid 19, xenophobia, security

Participants :
- University of Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €
Projet ACT5G (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

The rapid growth in mobile network data traffic contributed to the unprecedented speed of 4G LTE adoption, creating the need of sustainable capacity growth in next generation of wireless systems, namely 5G. A key success factor of 5G is network and management system design for flexibility by prediction and adaptation. To this end, anticipation is a promising new approach. By predicting and adapting to upcoming events at various time scales, an anticipatory network improving the operation quality and efficiency. First, network resources ranging from spectrum and buffers can be managed optimally to meet users’ requirements. Second, network operators can jointly plan how to share infrastructures and resources to meet their demands at lower costs and better energy efficiency. The ACT5G project addresses these challenges by two parallel research thrusts which we identify as Network Prediction and Reaction Mechanisms. The research in these thrusts ranges from analytic methods and models for anticipatory networks, to optimization in resource management and infrastructure sharing. To achieve the objectives, ACT5G engages in a four-year research program centered around four industrial PhDs. Half of the duration of the involvement of the early stage researchers (ESRs) in the program will be spent at the site of Alcatel Lucent Bell-Labs, giving the core industrial aspect of the ACT5G project. ACT5G brings together a consortium of complementary research skills, ensuring that the involved ESRs conduct top-level beyond-state-of-the-art research, while enjoying a well-structured program for industrial-oriented doctoral studies. The added value of ACT5G is the creation of a critical mass of trained researchers, working together under joint industrial/academic supervision. The outcomes of the project are have a direct impact on the evolution towards 5G networks, the career perspectives of the ESRs, and the human capital of the European Research Area.

Mots clés : anticipatory networking, infrastructure sharing, resource management, wireless networks

Participants :
- Politecnico di Milano (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 516122.64 €
- State of Maryland (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Nokia (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Linköping University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 527318.64 €
Projet ISOTRAPSS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The rapid identification of synthetic molecules that selectively inhibit some proteins among families of closely related proteins is one of the major unsolved problems of modern drug discovery. If such ability was at hand, it would radically revise our definition of the ‘druggable’ genome. The goal of this proposal is to expand the state-of-the art of rational drug design with a new strategy that combines cutting edge computational techniques with modern experimental biophysical methods. We aim to achieve selective inhibition of proteins that are highly similar to other related proteins. To do so we will exploit concepts from energy landscape theory to identify transient conformational states of proteins that can be trapped by ligands to achieve extremely high binding selectivity. To provide proof of concept for such strategy, we will focus efforts on the therapeutically relevant cyclophilin protein family. Computational work will focus on: 1) unravelling the conformational preferences of the most common cyclophilin family members, and 2) clarification of current controversies regarding the binding mode and structure activity relationships of known selective ligands. Experimental work will involve the characterization of purchased or custom-synthesized ligands in in vitro assays and crystal structure analyses. Overall, this project proposes fundamental advances in rational drug design, therefore expanding opportunities for the development of future small molecule therapeutics.

Mots clés : structure based drug design, molecular dynamics, free energy calculations, biophysical assays, cyclophilins

Participants :
- University of Edinburgh (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet MIRAGE (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The recent discovery of benzonitrile in a nearby cold molecular cloud (Taurus) marks the first detection of an aromatic species in the interstellar medium by radio astronomy. Benzonitrile provides a key link to benzene, which may be a low-temperature precursor to more complex polycyclic aromatic hydrocarbons (PAHs). Understanding the origin of PAHs will help answer fundamental questions about their role in forming interstellar dust as well as potentially prebiotic molecules—material that may be incorporated into new planetary systems. Computational models are used to pinpoint individual chemical pathways by inputting kinetic rates of various formation and destruction reactions and aiming to reproduce the molecular abundances determined by radio astronomy. Many of these rates have not been measured in the laboratory, especially at low temperature. The MIRAGE project aims to measure reaction kinetics of functionalized benzenes at temperatures relevant to the cold interstellar medium and use these measurements to understand radio observations of aromatics in Taurus molecular cloud. To do this, we will use a new technique in development at the Université de Rennes 1 that combines chirped-pulse (sub)mm-wave (CPMW) rotational spectroscopy with uniform supersonic flows generated by the CRESU technique. This apparatus (one of only a few in development worldwide) will be used to measure kinetics for reactions of benzene. These data are critical to accurately explain the observed abundance of benzonitrile, as well as predicting the abundances of other aromatic species currently targeted for detection.

Mots clés : gas phase kinetics, spectroscopy, radio astronomy, cold molecules

Participants :
- Université de Rennes (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196707.84 €
Projet SHDS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The recent earthquakes that have struck Europe the last decade, L’Aquila (2009) and Lorca (2011) have shown that even for a moderate seismic hazard level the seismic action can cause huge personal and economic losses. Therefore there is a need for new structural designs based on the performance of the structures during earthquakes rather than their strength. This project will focus on the development and verification of a novel seismic-resistant highly deformable reinforced concrete structure. This innovative design takes advantage of the superior deformability of reinforced High Deformability Concrete (HDC) elements to develop a structure with controlled performance, in which the structural damage is concentrated in especially designed elements. The new structural system combines ductile shear walls with flexible coupling beams designed with reinforced HDC. HDC is currently being developed by the host Institution as part of Anagennisi, a FP7 EU funded project, and utilises recycled rubber particles as replacement of both fines and coarse aggregates. A preliminary experimental investigation is being undertaken to characterise the mechanical properties of HDC, and complimentary testing is planned to be carried out as part of this fellowship. This initial multi-scale testing phase will be followed by the development of a material model and its implementation in a finite element software for the analysis and assessment of representative prototypes of seismic resistant highly deformable structures. The new structure will be more sustainable as it will be easily repairable after an earthquake and will have a better seismic performance avoiding non-structural damages. This project will contribute to the development of new technology in Europe, and will provide an important stepping stone for the fellow’s career.

Mots clés : fiber reinforced polymers, rubberised concrete, performance based seismic design

Participants :
- University of Sheffield (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €