Projet X-probe (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks
Panel : Physics
Statut du projet : CLOSED

This cross-disciplinary Marie Curie Innovative Training Network builds upon the transformative opportunities created by existing X-ray sources and new sources soon to be operative in Europe. These opportunities include using ultrafast X-ray sources to extract time-dependent structural information from proteins; and revolutionary possibilities created by X-ray Free Electron Laser radiation for an entirely new regime of pre-damage serial femtosecond crystallography. No lag should exist between building new sources and training the next generation of scientists well versed in using these facilities. Our research training will yield new scientific insights on fundamental properties of protein structure and dynamics: one of the most challenging problems in structural biology; and technological advancements in diverse fields from pharmacology to nanotechnology. X-probe creates close interdisciplinary collaboration between structural biologists, physical chemists, beamline engineers, software developers, and industrial partners. The rapidly changing state-of-the-art demands that young researchers are trained to meet these new experimental, technical and analysis challenges at the forefront of structural biology and photochemistry. X-probe’s interdisciplinary and intersectorial training network incorporates four leading European X-ray facilities (ESRF, MAXIV Laboratory, European XFEL, SwissFEL); three academic laboratories at the forefront developing X-ray tools to probe protein dynamics; and both large and small industrial partners. Four principal scientists in X-probe are female. X-probe builds close cooperation between traditionally separate fields of research at the very cutting edge of structural biology and creates a visionary training network that would not be possible within any of the individual partner states.

Mots clés : ultra fast protein structural dynamics, serial crystallography, protein nanocrystals

Participants :
- Universität Hamburg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 249216.48 €
- Board of the Swiss Federal Institutes of Technology (Suisse) — Partner, organization partner, Recherche, subvention : 0.0 €
- Sapienza University of Rome (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- Lund University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 263659.32 €
- AstraZeneca (Sweden) (Suède) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 263659.32 €
- Sapienza Innovazione (Italie) — Partner, organization partner, Recherche, subvention : 0.0 €
- Xtal concepts gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- University of Gothenburg (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 263659.32 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 262875.6 €
- Molirom srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 258061.32 €
- European synchrotron radiation facility (France) — Partner, beneficiary, Recherche, subvention : 262875.6 €