Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet A-LITHIA (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Nanogap electrodes have been a highly attractive research area for over 25 years. This is mainly due to their potential for realising next generation nanodevices and circuit elements with lower power consumption, faster speed, and higher level of integration, as well as investigating the fundamental properties of materials at the nano- or even molecular level. However, the lack of a facile, inexpensive, high throughput technique for the manufacturing of dissimilar nanogap electrodes has hindered their commercial and scientific exploitation. It is exactly at this junction that I strive to make significant advances with this proposal, by first implementing a novel patterning technique, adhesion lithography (a-Lith), to manufacture large aspect ratio (>100,000) metal electrode nanogaps (<50 nm) on a variety of substrates and then by fabricating and fully characterising nanoscale devices that will allow both understanding of the relevant device physics, alongside, advancing in device performance. Herein, I will firstly further develop the a-Lith key processing steps in order to establish a reliable protocol for the controlled geometry and uniform nanogap formation. Then I will follow a multidisciplinary research trajectory aiming at the development of high performance co-planar nano-scale electronic devices. Targeted proof-of-concept applications include radio frequency rectifying Schottky diodes, non-volatile ferroelectric tunnel junction memories, light-emitting diodes (LEDs), photodetectors, piezoelectric nanogenerators and molecular nano-junctions, the architectures and dimensions of which would be difficult or far too expensive to obtain with traditional patterning techniques (e.g. e-beam lithography). Finally, during my secondment, I will pursue the successful demonstration of fully functional non-volatile ferroelectric tunnel memory array over large area flexible substrates that will pave the way to the industrial deployment of this highly promising technology.

Mots clés : nanofabrication, oleds, ferroelectric tunnel junctions, photodetectors

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet NANOREM (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Nanoparticles (NPs), metal particles of less than 100nm, are increasingly emitted to the environment from a variety of anthropogenic sources. However, their toxic effects on living organisms, capacity to enter the food chain, and impact in environmental health are poorly understood. NANOREM is a research project aiming to provide the first comprehensive insight into the toxicity of zinc oxide (ZnO) nanoparticles in wetland plants. This information is essential to evaluate correctly the risk of releasing large quantities of NPs to the environment. In this project we will make use of cutting edge isotope techniques to trace the sources of NP pollution, and to understand how NPs might change the current paradigm of metal cycling and assimilation by plants. Furthermore, NPs will be synthesized from plants and plant extracts using novel methods, and fully characterized.

Mots clés : phytoaccumulation, nanoparticle byosynthesis, green synthesis, zinc oxyde nanoparticles, pollution tracing, runoff pollution, zinc stable isotopes, mc icp ms, abiotic stress, metal tolerance

Participants :
- University of Barcelona (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 170121.6 €
Projet ActiTOX (Horizon 2020, appel à projets 2018)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : SIGNED

Nanoparticles and new drugs are undergoing complex toxicity evaluation prior to their use in products for customers. However, the traditional pre-clinical testing protocols are delivering significant disadvantages both from ethical (animal testing) and functional (high attrition rate in clinical testing) point of view. ActiTOX reacts to this problem by the development of a novel, pre-clinical, high content, in vitro testing platform focused on the evaluation of nanoparticles/drugs via ADME (absorption, distribution, metabolism, excretion) toxicity studies. In order to advance the current state of art the project will employ biomimetic scaffolds, drug delivery systems, human induced pluripotent stem cells (iPSCs), 3D-microfluidics and modular bioreactor technology. ActiTOX aims to increase the relevance of in vitro studies and provide a scalable approach for their use in drug development and toxicological screening. In order to achieve the project goals, a training network enabling efficient short-term secondments of ER and ESR between academia and industry will be established. The cooperation between stakeholders helps closing the gap between them and oint innovation to foster the current state of the art. ActiTOX will mediate it via networking, research, training, workshop, innovation and dissemination actions in form of short-term secondments. The project fulfils the aim of a RISE project and delivers significant social impact, increases knowledge based economy and creates long lasting cooperation strengthening the European research area.

Mots clés : adme, nanoparticle toxicity, drug development, biological barriers, organotypic 3d models, biomimetic scaffolds, nanfibers, electrospinning, drug delivery, microfluidic, 3d printing, bioreactors

Participants :
- Czech Academy of Sciences (Rép. Tchèque) — Partner, beneficiary, Recherche, subvention : 105800.0 €
- Inocure sro (Rép. Tchèque) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 239200.0 €
- Orthosera gmbh (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 50600.0 €
- TU Wien (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 124200.0 €
- Ospin gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 64400.0 €
- Széchenyi István University (Hongrie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 193200.0 €
- Fraunhofer Society (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 23000.0 €
- University of Graz (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 69000.0 €
- Bioneer (Denmark) (Danemark) — Partner, beneficiary, Recherche, subvention : 0.0 €
- Biofabics lda (Portugal) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 322000.0 €
Projet Nano-OligoMed (Horizon 2020, appel à projets 2017)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : CLOSED

Nanotechnology has received widespread attention in the last several decades due to the technological breakthroughs it has enabled across sectors from electronics to medicine. Towards the great challenges that nanotechnology arise, Nano-OligoMed has the ambition to establish and support a network of international collaboration, enabling a collaborative scientific team to effectively use a diversity of approaches and strategies to generate and test hybrid nanomaterials for the efficient and safe systemic delivery of oligonucleotide-based therapeutic agents. To this end, we have set-up a joint multidisciplinary scientific collaborative programme that through exchange, international mobility, and strongly collaborative transfer of knowledge and training activities between 4 European and 3 extra-European countries, will bring together leading experts under the field of “nanomaterials in biomedicine”. The scientific aim of Nano-OligoMed is the creation of degradable hybrid structures that combine the rigid, inert silica with the delicate programmable oligonucleotides or artificial oligonucleotide-mimics. The possibility to develop novel oligonucleotide-based materials will enable a) the degradation of the drug carrier at the presence of a specific input as a function of the intrinsic bio-responsive feature of oligonucleotides, b) the activation of a therapeutic function as a result of the bio-molecular interaction between the oligonucleotide-based material and the molecular target (i.e. miRNAs) and c) the delivery of the chemical payload (DNA and/or artificial mimics, even in combination with cancer drugs) upon cell internalization. The international academic networking, the broadening of the research skills, the educational activities, will provide to young (PhD students) and senior scientists, specific competences in the field of materials sciences, nanotechnology, molecular biology and molecular medicine.

Mots clés : dna nanotechnology, hybrid supramolecular chemistry, rnai, smart drug delivery

Participants :
- University of Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 67500.0 €
- University of Parma (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 121500.0 €
- McGill University (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Rome Tor Vergata (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 162000.0 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Havana (Cuba) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Nanomol technologies sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 126000.0 €
- Université de Strasbourg (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 121500.0 €
Projet ScaLeITN (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Nanotechnology is paving the way toward nanoscale devices that are envisioned to enable several groundbreaking healthcare applications, such as molecular-level cancer detection, targeted drug delivery, and neurosurgeries. The nanodevices are expected to flow through the human body, perform actions upon commands or at certain locations, and communicate the results to the outside world. There is, therefore, a need to enable two-way communication between the nanodevices and the outside world, as well as their localization inside the body. These functionalities should be supported while simultaneously maintaining tiny form factors and a low energy consumption profile of a potentially vast number of nanodevices. In the ScaLeITN project, I will utilize wireless signals in the terahertz (THz) frequencies for enabling both localization and communication capabilities for in-body nanodevices. Localization will be enabled through THz backscattering, which is an unexplored paradigm that promises low energy and high precision localization at the nanoscale. The constrained communication range characteristic for in-body THz propagation will be mitigated through multi-hop communication. In such communication, only a selected subset of nanodevices in the multi-hop route will be awoken by utilizing wake-up radio-like signals. Selection of these nanodevices will be based on their location estimates, as well as on their energy lifecycle characterizations if available through backscattering. This is again a novel paradigm that promises enabling low power, reliable, and scalable THz nanocommunication. The main outcome of the project is to develop a pioneering prototype of a THz nanonetwork with both localization and two-way communication capabilities. Market valorization of the prototype is envisioned during and beyond the scope of the project through the Collider and i.start, two academic innovation programmes for supporting scientists in developing disruptive technology-based products.

Mots clés : nanocommunication, terahertz, backscatter localization, in body healthcare, prototypical implementation

Participants :
- University of Antwerp (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 178320.0 €
Projet GenerationNano (Horizon 2020, appel à projets 2019)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

Nanotechnology is widely considered to be one of the drivers of innovations in the 21st century. Specifically, nanoscience strongly contributes to several of the key enabling technologies identified by the European Commission, including Nanotechnologies, Advanced Materials and Biotechnologies, and Sustainable development. In this way, nanotechnology also has significant potential to directly address Europe’s Societal Challenges, including clean and efficient energy, resource efficiency, health and well-being. The effective use of nanotechnology requires a highly trained workforce able to tackle interdisciplinary challenges through combination of unique approaches, advanced materials and characterization techniques coupled with a clear understanding of technology and market needs. The GenerationNano program will effectively consolidate and leverage externally (public and private) funded projects to facilitate a cohesive training program that integrates multiple disciplines, mobility, training in innovation processes and leadership to produce tomorrow’s leaders in nanotechnology and nano-innovation. GenerationNano’s is highly timely and is specifically designed for the Lund region in Southern Scandinavia. First, large investments into basic nanoscience have by now built up an extensive base of knowledge, infrastructure and materials synthesis capabilities related to nanostructures, and a large number of highly innovative applications are emerging. The time to focus on future applications is now. Second, the project is perfectly timed to coincide with major investments into regional nanotechnology e.g. world-leading nanomaterials research at NanoLund (the host of GenerationNano); the worlds brightest synchrotron MAX IV; ; the start of institute- and pilotfabrication operations (ProNano) within nanotechnology in Lund by RISE, to bring nanotech innovations from proof-of-concept all the way to production; and multiple nanotech companies.

Mots clés : nanotechnology and nano innovation, multi disciplinary, intersectorial, esr mobility, training in, innovation processes and leadership, transparent and merit based recruitment

Participants :
- Lund University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1518720.0 €
Projet CLAYLAB (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Natural clays are fascinating materials, especially so-called quick clays, a major geohazard, which are natural soils that can have a sudden irreversible phase change from solid to liquid due to small perturbations in environmental conditions. The aim of the project is to gain understanding of the complex behaviour of natural sensitive clays, including quick clays, by creating a virtual CLAYLAB. CLAYLAB is a virtual geomechanics laboratory for probing the behavior of clays starting at the materials science scale by incorporating clay specific physics in Discrete Element Modelling (DEM), based on experimental image and force data that spans nm - m. The novel multi-scale experimental data available at the host institution is combined with micro-mechanical computational and theoretical methods such as adding Level Sets for shape to DEM with the expertise of the ER. By taking advantage of cutting-edge imaging techniques, such as X-ray Computed Tomography, where computer-based mathematical schemes such as level sets are applied to generate a unique “digital twin” for each particle. Furthermore, complementary data is gathered on the physico-chemical processes using a combination of X-ray scattering and Atomic Force Microscopy. Ultimately, a virtual CLAYLAB will be created, so that the digital samples match the physical behavior of their real counterparts at the engineering scale. CLAYLAB will enable us, for a first time, to understand the phenomena such as quick clay landslides, and enable us to probe into the materials response beyond what is possible when using laboratory techniques on their own. This understanding ultimately offers a platform to develop novel ground improvement ideas for landslide mitigation. Finally, CLAYLAB will help to ameliorate time consuming as well as expensive real laboratory testing procedures for probing soil response for engineering applications.

Mots clés : virtual laboratory, natural clay, lsdem, nano scale characterisation

Participants :
- Chalmers University of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203852.16 €
Projet ENCOUNTER (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Natural mentoring relationships (NMRs) can positively affect children's cognitive and socio-emotional development, well-being, and authentic agency. In addition, NMRs contribute to the intergenerational dialogue and social cohesion in EUs societies, that is, to the current priorities of the EU Council’s youth policy. Though formal youth mentoring interventions (FYM) that aim to foster the benefits of NMRs for socially disadvantaged youths are modelled on NMRs, there is a gap in knowledge on the dynamics and benefits of NMRs experienced in the general population of young adolescents (12-15 years) in the EU. Besides, despite the recognised benefits of NMRs, no mentoring programmes target the empowerment of youths in mentoring skills in the general population. Building on my previous experience and research on youth mentoring, the ENCOUNTER aims to examine the NMRs in experiences of young adolescents in the EU context, using the exploratory qualitative research design that draws on phenomenological interviews and visual participatory methods (PhotoVoice), and focusing on three main objectives: • RO1: To examine the characteristics, dynamics, and perceived benefits of the natural mentoring relationships experienced by young adolescents in an EU context • RO2: To conceptualise the theoretical, interdisciplinary youth-centred framework on natural mentoring phenomena by reviewing the relevant theories on youth’s development across disciplines, and research literature on NMRs. • RO3: To contrast the functions, characteristics, and dynamics of NMRs among gender; and the features of NMRs experienced by young adolescents in the CZ and in an international context. ENCOUNTER will expand research, theory, and practice in the field in EU context by implementing novel methodological approaches in the field, enabling interdisciplinary conceptualization of natural mentoring phenomena, and addressing UN SDG Goals 2030 and EU’s Youth Sector Strategy 2030.

Mots clés : natural mentoring, qualitative research, new sociology of childhood, development in the social context, children s studies, participatory methods

Participants :
- Charles University (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 144980.64 €
Projet MILO (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Natural resources including raw materials are important for the European Union since they are a part of the base of the economy and simultaneously a large pollution and waste source. Sustainable development of the mining sector extracting the raw materials calls for an economic analysis of environmental policy, which is the central theme of the MILO-project. The objective of the project is to investigate the optimal environmental policy of the mining sector with a special emphasis on mining specific features and the choice of policy instruments under lobbying. Through its research results obtained using dynamic optimization methods, game theory and an array of dissemination and communication efforts, the project will help to improve the currently applied policies in Europe. In addition to policy advice, the project will result in new insights on the formation of lobby groups and policy instruments by combining two game theoretical approaches, namely, the common agency framework and coalition theory modeling. The researcher, who is trained in the theory of environmental policy instruments and dynamic optimization methods, will conduct the research and training in FEEM’s international and interdisciplinary working environment and will be supervised by an expert in the research field. The project with its trainings improves his research and transferable skills, and extends his international networks through the host’s contacts and through a research visit. By including versatile training-through-research, multiple dissemination and communication methods, public engagement through the MILO-webpage and blog, and networking the project has a strong impact on the researcher’s career, on the future research collaboration as well as on the public interest.

Mots clés : exhaustible resources, dynamic analysis, game theory, lobbying

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165254.1 €
- Fondazione Eni Enrico Mattei (Italie) — Partner, beneficiary, Recherche, subvention : 15023.1 €
Projet CYCLOTUBES (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Naturally occurring living materials, for e.g. the cell cytoskeleton, consist of intricate supramolecular polymers whose self-assembly is controlled by high energy molecules such as guanosine triphosphate GTP. MiNaturally occurring living materials, such as the cell cytoskeleton, consist of intricate supramolecular polymers whose self-assembly is controlled by high energy molecules such as guanosine triphosphate GTP. Microtubules for example, are incredibly strong, but because they are chemically fueled by GTP, they can be built up or broken down at specific times and locations inside the cell. The tubules are in so-called non-equilibrium steady states, and are kept away from the thermodynamic equilibrium for extended periods of time. In the recent years, artificial supramolecular polymers have been made that are transiently out-of-equilibrium by addition of a single shot of chemical fuel, or for long times by continuous addition of fuel and removal of waste. The mechanical properties of the latter artificial systems are quite poor in comparison with real microtubules. The aim of this CYCLOTUBES project is to make artificial microtubules from cyclic peptides that can chemically or enzymatically be switched between the assembled and disassembled state. To this end, we will use oxidation and reduction reactions in a cell-like environment, that is, in a membrane enclosed chamber. In the latter, chemical fuel can be added and waste be removed continuously. In addition, the assembly/disassembly of the artificial tubules can be monitored using microscopy. Our work will give fundamentally new insights into out-of-equilibrium self-assembly, and could lead to novel life-like materials that are capable of performing significant mechanical work due to the unique mechanical properties of the cyclic peptide tubules. The candidate will work at the forefront of the field of systems chemistry and supramolecular chemistry, which are very important for the competitiveness of Europe.

Mots clés : systems chemistry, cyclic peptides, enzymes, redox

Participants :
- Université de Strasbourg (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €