Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CIRCLE (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This project will investigate the role of CYLD in Chronic Lymphocytic Leukaemia (CLL). CYLD is a deubiquinating enzyme acting as a tumour suppressor in numerous tumours. CLL is characterized by the accumulation of B-lymphocytes. It affects mostly the elder and has a high incidence rate in Europe. Recent data from CYLD knockout murine models indicate a link between CYLD and CLL, however the approach used for generation of these mice led to contrasting results. At the core of this interdisciplinary project is the generation of two transgenic murine with: i) targeted CYLD inactivation in B-lymphocytes, ii) targeted inactivation combined with a murine model of CLL. Targeted inactivation will be achieved using the Cre-Lox system, by crossing already available progenitor mice. The mice will be extensively characterized with an emphasis on B-lymphocytes development and pathophysiology. RNA-seq will be used to find differentially expressed genes in B-lymphocytes. Computational biology approaches will then be applied to identify the affected pathways, which will be evaluated against publicly available human CLL data, seeking wider consensus. CYLD targeted inactivation allows for the first time evaluation of CYLD's role in B-lymphocytes development and CLL ruling out the effect CYLD inactivation in other cells may have. This project will enable better understanding of the role of CYLD in B-lymphocytes biology and could unravel novel biomarkers and therapeutic targets. At the same time the applicant will train-through-research, master novel techniques and develop soft skills valuable for his future career. This project combines the applicant’s expertise in the generation and characterization of murine models with targeted CYLD inactivation with the host's long track record in B-lymphocytes and CLL.It falls well within the EU’s research agenda, which emphasizes interdisciplinary research leading to recognition of common disease mechanisms and identification of novel biomarkers.

Mots clés : cyld, animal model

Participants :
- Vita-Salute San Raffaele University (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet LABVaccFish (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This project will provide a proof of principle that food-grade lactic acid bacteria (LAB) can be used as vehicle for oral vaccination of fish and will unravel the underlying mechanisms of memory formation in zebrafish. We will engineer Lactococcus lactis to deliver a DNA- or protein-based prototype vaccine against spring viraemia of carp virus (SVCV). The choice of virus and antigen is based on work showing that injection vaccination with DNA plasmids encoding the G protein of SVCV is highly successful. This vaccination route however, is less suitable for mass delivery and alternative strategies aiming at delivering the vaccine via the oral route are required. Food-grade lactic acid bacteria as vaccine vehicle are an attractive strategy to deliver vaccines at mucosal surfaces that has never been investigated in fish. We will use zebrafish as animal model to monitor real-time vaccine uptake and kinetics of immune responses. Already available knock-out and transgenic zebrafish lines expressing reporter genes under the control of cell- or cytokine-specific promotors will help dissect the contribution of innate and adaptive immune responses induced by vaccination. We will develop novel transgenic zebrafish lines for the controlled ablation of zebrafish cytotoxic T lymphocytes (CTL), to test the hypothesis that long term protective immunity to SVCV is mainly CTL-mediated. Altogether, this project will provide a proof of principle for the development of mucosal vaccines suitable for mass delivery in fish using commensal bacteria, supported by the unravelling of immune mechanisms important for memory formation using zebrafish as animal model. This project will familiarize the candidate with mucosal immunology using state-of-the-art techniques such as transgenesis and live microscopy in an animal model of high interest to the Life Sciences; this will promote his development as independent researcher and facilitate the acquisition of a stable research position in Europe

Mots clés : zebrafish, vaccination, immunology, mucosal immunity, microbiology, virology, dna vaccin

Participants :
- Wageningen University & Research (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet CONSENT (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

This project will study the evolutionary ecology of senescence – how and why biological performance declines with age. Understanding senescence in nature requires us to study interactions between the environment and natural and sexual selection and how they shape patterns of ageing. I will study life-history trade-offs in both lab and natural environments exploiting an existing project on a wild cricket population that has amassed 12 years of data. My study system consists of annual generations of a few hundred individually tagged, video-monitored and genotyped individuals. This system will allow me to address evolutionary questions about senescence that are very hard to study in much longer lived vertebrates. My approach of studying senescence in both lab and field environments is timely in the face of the current state of the art showing that the fitness outcomes of genetically controlled pathways with pleiotropic early and late-life effects depend on the environment in which they are studied. I will use techniques in eco-physiology (telomere measurements), animal breeding (quantitative genetics), and evolutionary ecology (life-history trade-offs and animal behaviour) to study the extent to which (i) telomeres can be used as biomarker of ageing in insects, (ii) life-history trade-offs including behaviour underpinning senescence, and (iii) the extent to which these phenotypic correlations are also expressed as genetic correlations i.e. are they heritable? These questions are key to solving the enigma of ageing, and their answers will be important for research aimed at understanding processes that drive the demographic ageing of Europe’s society. In my past research I led an eight-year experiment testing the trade-off between reproduction and ageing and telomere shortening in a large wild bird population (papers in Ecol. Lett. 2014 & 2015 & Proc.Soc.B 2014). I am excited to switch to insects to address questions that have never been tackled in their natural context.

Mots clés : life history trade offs, heritability, natural selection, sexual selection, behavioural ecology

Participants :
- University of Exeter (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet TANBCPdyes (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This project, “Triggerable, Anchoring Novel Block Copolymer Dyes (BCP dyes) for Use in Inkjet Printing” (TANBCPdyes), is an intersectoral multidisciplinary project that will develop a new technology platform based on specially-designed materials. The development of novel inkjet printing materials is greatly needed to satisfy the growing demands of this quickly evolving market which spans applications including simple home & office devices to food packaging and high-tech inkjet printing of displays. The synthesized BCP dyes will be processed from water, an environmentally friendly solvent (thus eliminating the use of hazardous volatile organic solvents in the process), but will become insoluble & water resistant after deposition on the substrate. Therefore, new materials will act as waterborne dyes in a wet state & become fixed onto the substrates after thermal treatment. Success will allow novel BCP dyes to be manufactured on a large scale at high-throughput levels by drawing on the expertise of Aston University, University of Warwick, University of Tubingen & the industrial partner, Domino UK Ltd, which will allow EU industries to reinforce their position in the global technological race in the field of inkjet printing. The Fellow will develop new scientific skills through the synthesis & advanced characterisation of BCP dyes; benefit from the direct mentoring and supervision of a team of renowned EU scientists (Prof Topham, Prof Perrier, Dr Leslie, Prof Peisert and Dr Harries); gain professional training to promote his growth & independence; take significant steps toward establishing his own network of EU researchers, & also enhance his relationships with Aston & the secondment project partners (Warwick, Tubingen & Domino). The Fellow will bring his expertise in polycondensation chemistry, membrane technology, biomolecules (e.g. proteins) separation, and conductive/photoactive nanomaterials to Aston, creating new research avenues in the Topham group.

Mots clés : waterborne block copolymers dyes, iterative raft polymerization, inkjet printing, hydrophobic substrates

Participants :
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet Carnap and the Limits of Metaphysics (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This project’s overall objective is to use state of the art research in the formal theory of knowledge to advance our understanding of the scope and limits of metaphysics. Specifically, the project will argue that the most important threat to the value of metaphysics comes from epistemic arguments given by Carnap, and that responding to these arguments requires drawing on considerations from formal epistemology. The master argument that will focus this project draws on Carnap's (1928) epistemic critique of metaphysics: 1. No possible evidence can justify a metaphysical statement. 2. If no possible evidence can justify a metaphysical statement then we can have no justification to believe a metaphysical statement. Conclusion: We can have no justification to believe a metaphysical statement. The deliverables will be six papers published in leading journals. The first will argue that critiques of metaphysics based on semantics do not succeed. The second will argue that epistemic criticisms of metaphysics are effective, specifically Carnap's. The third will defend premise 1, arguing that the rationalist renaissance of recent years has done little to undermine the relevant empiricist thesis. The fourth defends premise 2 as applied to the question of ontology (‘what exists?’), arguing that the non-empirical considerations used by objective Bayesians can be applied to metaphysics. The fifth criticizes premise 2 as applied to the question of modality (‘what it necessary?’), arguing that non-empirical considerations cannot help us determine the gap between the necessary and the contingent. The sixth develops the anti-realist theory of modality that follows, arguing that it makes best sense of the core intuitions of both sides of the argument. These deliverables will expand the ER's core strengths into metaphysics, re-integrate him into Europe and establish him as one of the leading European experts in formal epistemology and the methodology of metaphysics.

Mots clés : carnap, metametaphysics

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet INFINITY (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This project’s research goal is a systematic philosophical and mathematical analysis of critical views of infinity: views which have questioned one or more aspects of standard approaches to infinity in mathematics. Criticism of infinity originates in fundamental debates at the turn of the 20th century and re-emerges in contemporary mathematics under the stimulus of computer applications. The project’s first aim is to develop a novel rigorous examination of what is objected to infinity and why. The next goal is a philosophical and mathematical analysis of this criticism and of strategies proposed to overcome the perceived problematic nature of the infinite. To achieve these goals, the ER will integrate precise philosophical inquiry with state of the art knowledge of contemporary mathematics. She will analyse the early 20th century texts and compare that criticism of infinity with the one which emerges in contemporary mathematics; she will use a range of logical tools to sharpen and analyse the fundamental concepts of this debate. The ER has the ideal profile to initiate, with the support of the host institution, an interdisciplinary analysis of the mathematical infinite, as she is simultaneously a mathematician and a philosopher, with years-long experience in logic. The Department of Philosophy at the University of Oslo is the perfect research environment for carrying out this project: the supervisor, Professor Øystein Linnebo, is leading figure in EU’s philosophy of mathematics and this project is very well aligned with his group’s research interests. Through a programme of training through research, the ER will strengthen her philosophical readership, broaden her range of competences, forge new connections to the philosophical community and gain skills in dissemination and communication. This project will be an important point of departure for her future academic career, proposing her as unique bridge between the EU’s philosophical and mathematical communities.

Mots clés : philosophy of mathematics, infinity, predicativity, intuitionistic logic, intuitionistic type theory, henri poincar, hermann weyl

Participants :
- University of Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €
Projet Photo SCO LCs (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

This proposal aims at developing a series of photoresponsive magnetic soft materials through the combination of spincrossover (SCO) property, photochromic property and liquid crystal (LC) property in a single material. The SCO property comes from the switchable electronic state between high-spin (HS, S = 2) and low-spin (LS, S = 0) state of the Fe(II) center in an octahedral coordination sphere under an external stimuli (e.g. temperature, light and pressure) and display an interconversion between diamagnetism and paramagnetism. The SCO molecules will be further decorated with long alkyl chains, which are covalently inserted by azobenzene group as photochromic unit, to display both LC and photochromic properties. The reversible cis/trans conformational change of photochromic unit is expected to change the coordination sphere of Fe(II) center and intermolecular interactions in LC systems, thus tuning the ligand field and SCO cooperativity and giving novel ligand-driven light-induced spin change effect (LD LISC) behavior. Moreover, if compared to traditional solid crystalline materials, the obtained materials will show superior characteristics, such as reversibility, faster response, and improved fabricability, allowed by the flexible nature of LCs. The obtained photoresponsive SCO LC materials will have multidisciplinary applications in prototypes of optical memory devices, displays, sensors, and switches, etc. The proposal designed by the researcher and host will make a contribution and promotion in the development of multifunctional molecular magnets, especially of photomagnetic materials.

Mots clés : spin crossover, liquid crystal, photochromism, photomagnetism, ld lisc, azobenzene

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 196707.84 €
Projet DC FlexMIL (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This proposal aims at the development, characterization and control of a novel class of high repetition rate ultra-short pulse lasers featured by stable, flexibly shapeable emission properties combined in an integrated format (i.e. on chip). The associated benefits in terms of cost, size, and power consumption paired with the intrinsic flexibility are unquestionably significant characteristics to fulfil the dynamic needs of numerous sophisticated applications in the broad areas of metrology, telecommunications, microchip-computing etc., and will in turn enable to finally bring these innovative integrated lasers to the public market. By exploiting a high-Q microring resonator, a novel mode-locking approach named filter driven four-wave mixing (FD-FWM) will be used to achieve stable high-quality spectral emission. Enabled by this scheme, we will investigate and exploit the interesting effect of higher-order modulation instability dynamics (a higher-order characteristic of the mechanism responsible for laser mode-locking, not yet explored), to control and shape the emission as well as the noise properties of the proposed integrated laser device. In particular this will be achieved by dynamically controlling the main cavity dispersion of the system via incorporated specially designed Bragg grating waveguides. In parallel with the investigations on the controllability of the laser emission, the integration of the whole device will be pushed forward by designing and fabricating microring resonators based on silicon (oxy)nitrite technology as well as by developing a novel miniaturized laser scheme based on semiconductor optical amplifiers. The external optical control possibilities of the laser scheme proposed here will be exploited with a view to synchronize two lasers, a highly important achievement for next generation multi-source telecommunication networks.

Mots clés : integrated optics, mode locked lasers, semiconductors, micro system  engineering

Participants :
- University of Glasgow (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 255349.8 €
- Université du Québec (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SERENA (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

This proposal aims to address the unmet needs, opportunities, and challenges in the field of liquid biopsy and PoC devices for the detection of emerging cancer biomarkers in blood. Circulating microRNAs and long non-coding RNAs as well as autoantibodies are promising cancer biomarkers for liquid biopsy. My goal is to develop a rapid, portable, easy-use, and reliable electrochemical nanostructured multisensor platform for their simultaneous detection in whole blood for early breast cancer diagnosis, prognosis and patient follow-up. I will merge the advantages of nucleic acid analogues with those of graphene-nanoparticle hybrid composites to develop a platform based on the use of inexpensive screen printed electrodes, produced by cutting-edge green technologies. An interdisciplinary approach will drive me towards the development and delivery of this novel diagnostic device with tremendous potential in nanomedicine. This fellowship aims to build on my recognised background in DNA nanotechnology and achieve new complementary expertise in electrochemistry, cutting-edge nanotechnology and nanoscience-based biosensors, through knowledge transfer and related training activities under the supervision of Prof. Merkoçi, a world-renowned expert in these fields. Meanwhile, the host institution (ICN2) will benefit from my skills in DNA nanotechnology for bioanalytical applications. Moreover, this fellowship will allow me to refine and acquire complementary transferable skills, including proposal writing, patents and IPR, project management, and leadership skills. I intend also exploit the opportunities to develop professionally by supporting the ICN2 Communication Department and by getting involved in the ICN2’s gender actions. The original scientific output and added-value career development benefits of this fellowship would greatly support me in gaining the necessary skills and credentials to become an independent and productive European PI.

Mots clés : artificial nucleic acids, biosensors, point of care device, printing technology

Participants :
- Institut Català de Nanociència i Nanotecnologia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 160932.48 €
Projet POTENTIATE (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This proposal aims to unravel to signalling pathways that underlie induced plant cell totipotency, by combining cell and molecular techniques to chart the changes that take place as differentiated pollen cells are induced to switch developmental pathways and form embryos in culture. Immature male gametophytes can be induced to change their developmental fate from pollen to haploid embryo development when exposed to stress treatments in vitro. This process (microspore embryogenesis) is widely exploited in plant breeding to generate homozygous (doubled-haploid) lines in a single generation, and also provides a unique system to understand plant totipotency and early cell fate decisions. In this proposal, I aim to understand the molecular basis for this switch in developmental pathways in Brassica napus. I will combine cell tracking, cell sorting of fluorescently tagged cells and high-throughput transcriptome sequencing to chart the changes that take place as immature pollen are converted into haploid embryos, and will also determine the function of a selection of genes in the model plant, arabidopsis. The project will advance my career by broadening my existing cell biology expertise, by providing training in a new field, molecular biology, and by allowing me to work with the plant model, arabidopsis. In addition, my network will be expanded to include a large group of internationally active scientists and seed companies. This novel combination of classical and state-of the-art skills, combined with the experience of working with top international groups and a plant breeding company, will place me in a solid position for a career in academia or industry.

Mots clés : totipotency

Participants :
- Wageningen University & Research (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €