Projet DeLIVER (Horizon 2020, appel à projets 2017)
Action : Doctoral Networks
Panel : Physics
Statut du projet : CLOSED

DeLIVER will train a new generation of ESRs in the development and application of newly developed high speed and high resolution imaging tools in biomedical research. ESRs will be cross-pollinated with concepts and skills in physics and biomedicine, in particular in super-resolution optical imaging (a.k.a. optical nanoscopy), analytical image reconstruction, and optical micro-manipulation methods. These skills are applied to reveal for the first time the function and dynamics of nanosized pores in endothelial cells (EC) that present the main barrier between the blood and vital organs for human physiology, such as the liver, brain, kidneys, and the eyes. Very little is known about the extremely important physiological function of these unique structures and their role in the transfer and/or clearance of metabolites and pharmaceuticals to vital organs. The current generation of optical nanoscopes, however, is rather slow and can only be applied to isolated, typically fixed (i.e. dead) cells rather than biomedically relevant tissues. Also, newcomers to the field need to familiarize themselves with a whole new set of potential problems that might arise in the use of optical nanoscopy, such as image reconstruction-related artifacts to name just one example.This is an area of research where European enterprises are very active. Excellent training in new scientific and complementary skills, combined with international and intersectoral work experience, will instil an innovative, creative and entrepreneurial mind-set in DeLIVER's ESRs, maximising economic benefits based on scientific discoveries. These specialised, highly trained, and mobile ESRs will have greatly enhanced career prospects. The training in novel physical methods with highly relevant experience in the biomedical sciences will allow them to confidently navigate at the interface of academic, clinical and private sector research.

Mots clés : optical nanoscopy, high speed optical imaging, nanopores, cellular fenestrations, nanolipoproteins, lipid rafts

Participants :
- Anzac health and medical research foundation (Australie) — Partner, organization partner, Autres, subvention : 0.0 €
- University of Gothenburg (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 263659.32 €
- Miltenyi Biotec (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- Bayer (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Cherry Biotech (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 262875.6 €
- Elvesys (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 262875.6 €
- Bielefeld University (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 747649.44 €
- Norinnova (Norway) (Norvège) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Hong Kong (Hong Kong) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- UiT The Arctic University of Norway (Norvège) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 1145100.96 €
- Government of the United States of America (Etats-Unis) — Partner, organization partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- University of Birmingham (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- Vrije Universiteit Brussel (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 250560.0 €
- University of Oxford (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €