Projet MENTOR (Horizon Europe, appel à projets 2023)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

MENTOR is a multi-disciplinary training network which focuses on the mTOR pathway, a central mechanistic hub that integrates nutritional cues and controls cell growth and metabolism. Aberrant activation of mTOR underlies monogenic diseases with broad spectrum of pathological manifestations, including tissue overgrowth, polycystic kidneys and neuropsychiatric disorders affecting around two million of people worldwide. To avoid the medical errancy of patients in different clinical departments and surgical mutilations, approaches of personalized medicine depending on the genetic landscape need to be implemented, taking advantage of suitable pharmacological products. The overall goal of the MENTOR research program is to: delineate molecular mechanisms of fundamental and aberrant mTOR functions, preclinically decipher the pathophysiology of mTOR, develop a novel arsenal of drugs to selectively target the pathway and provide proof-of-concept support for such interventions. This ambition can only be achieved by the multidisciplinary research program that MENTOR has conceived, through the training of a new generation of scientists at Graduate Schools of biology, pharmacy, chemistry or medicine that will become the leaders of mTOR research in both public and private sectors. MENTOR will establish a collaborative and efficient network from academia to industry, involving patient associations and clinicians with impact on scientific community and society.

Mots clés : multidisciplinary, growth, genetics, mtor

Participants :
- Telethon Foundation (Italie) — Partner, beneficiary, Recherche, subvention : 259437.6 €
- Essen University Hospital (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 521078.4 €
- Université de Naples - Frédéric-II (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Fribourg (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- KU Leuven (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262620.0 €
- Université Eberhard Karl de Tübingen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 521078.4 €
- University Medical Center Utrecht (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274370.4 €
- International Institute of Molecular and Cell Biology (Pologne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Bâle (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Mimetas (Netherlands) (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 274370.4 €
- Institut national de la santé et de la recherche médicale (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Assistance publique - Hôpitaux de Paris (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Cell signaling technology, inc. (Etats-Unis) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Sorbonne Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre National de Recherches Oncologiques (Espagne) — Partner, beneficiary, Recherche, subvention : 251971.2 €
- Foundation for Research and Technology Hellas (Grèce) — Partner, beneficiary, Recherche, subvention : 240098.4 €
- Université autonome de Madrid (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Ioannina (Grèce) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- The myrovlytis trust (Royaume-Uni) — Partner, associated partner, Autres, subvention : 0.0 €
- Pd-value bv (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 274370.4 €
- Université Paris Cité (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 565387.2 €
- Institut du cerveau (France) — Partner, beneficiary, Recherche, subvention : 282693.6 €
- Biosolveit gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Miedzynarodowy instytut mechanizmow i maszyn molekularnych polskiej akademii nauk (Pologne) — Partner, beneficiary, Recherche, subvention : 226512.0 €
- Topadur pharma ag (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- European tuberous sclerosis complex association (e-tsc) (Allemagne) — Partner, associated partner, Autres, subvention : 0.0 €