Projet CONTRA (Horizon 2020, appel à projets 2017)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

Cancer is a major cause of death and suffering, rendering it a huge concern to the general public. Consequently, it has been targeted by application of the molecular techniques developed during the last 20-25 years, thereby improving diagnosis and treatment. Nevertheless, although current biomarker and treatment concepts often are successful initially, they subsequently frequently fail to achieve durable drug response and long-term survival for cancer patients. The study of somatic evolution in cancer is a very promising approach to rectify this situation. Fortunately, single cell genomic sequencing has recently begun to provide opportunity to unprecedented detailed insights into tumour evolution and new techniques are emerging for assaying the spatial distribution of tumour heterogeneity. Analysing and developing methods for these emerging data sets are under-researched areas that lie at the intersection of medical, evolutionary biology, and computational research. In CONTRA, European researchers with complementary expertise have joined forces in order to collectively facilitate training of future European computational cancer researchers. We will by applying modern recruitment and selection methods in combination with offering excellent training and employments conditions, including social security, facilitate recruitment of 15 excellent ESRs, across genders and geographical areas. We will train these 15 ESRs in the mathematical, computational, and applied skills required to tackle the complex analysis problems posed by somatic evolution in cancer. We will also teach them entrepreneurship and the requirements of pharmaceutical and biotech industry. Using a novel scheme, this substantial academic cancer expertise will be complemented with industrial expertise in software development, especially for biotech and pharmaceutical industry, which will unleash key components of the innovative force of the European commercial sector in the struggle against cancer.

Mots clés : somatic evolution in cancer, tumour evolution in cancer, single cell sequencing, cancer metastasis, circulating tumour cells, tumour phylogeny, tumour cell morphology, mutations in cancer

Participants :
- Merck (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Centro Tecnolóxico de Telecomunicacións de Galicia (Espagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Board of the Swiss Federal Institutes of Technology (Suisse) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 530453.52 €
- Spatial transcriptomics ab (Suède) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 546575.76 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 546575.76 €
- Torus software solutions s.l. (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Warsaw (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 448274.88 €
- KTH Royal Institute of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 527318.64 €
- Ardigen sa (Pologne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- British columbia cancer agency branch (Canada) — Partner, organization partner, Recherche, subvention : 0.0 €
- Seven bridges genomics uk ltd (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Universidade de Vigo (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 495745.92 €
- Institute for Research in Biomedicine (Espagne) — Partner, beneficiary, Recherche, subvention : 495745.92 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €