Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet BreaKer (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Breast cancer is the second cause of cancer-related death in women. Although cancer immunotherapy emerged as a successful therapy for many cancer types, the response of metastatic breast cancer patients to immune checkpoint blockade remains disappointing, urging for a better understanding of the breast cancer immune landscape. iNKT cells are lipid-specific T cells that bridge innate and adaptive immunity and exert a plethora of immune functions depending on tissue distribution. Despite their known antitumor potential, they have been largely overlooked in the cancer field for their content paucity in cancer patients. I hypothesize that their scarce abundance and poor activation status is caused by cancer-induced immunosuppressive mechanisms. Indeed, I observed that circulating and metastasis-infiltrating iNKT cells are functionally impaired in the K14cre;Cdh1F/F;Trp53F/F(KEP)-based mouse model of de novo breast cancer metastases. With a translational approach, I will provide an unprecedented comprehensive dataset comparing iNKT cell immunophenotype in metastatic breast cancer patients and healthy controls. Next, I will generate human iNKT cell lines to perform in vitro mechanistic studies aimed at assessing how cancer-associated inflammation can modulate iNKT cell antitumor activity. Moreover, the innovative use of iNKT cell deficient Jα18-/- mice coupled to the KEP-based model of breast cancer metastases, will offer a clear picture of the role of iNKT cells and their cancer-associated cellular networks during the metastatic cascade. Finally, I will in vivo deplete immunosuppressive cells to unleash iNKT cell antitumor activity. My solid knowledge of iNKT cell biology combined with the expertise in breast cancer-associated inflammation of the hosting lab and the cutting-edge clinical research of the institute will uniquely generate fundamental knowledge with high applicative potential for the design of novel combinatorial immunotherapies for metastatic breast cancer.

Mots clés : inkt cells, breast cancer metastasis, cancer immunosuppression, myeloid cells, breast cancer patients, genetically engineered mouse models, translational research

Participants :
- Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 175572.48 €
Projet NAUTIC (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Bringing a new drug to the European market takes at least 10 years and 2.5 BEUR of R&D effort. Computational methods significantly shorten this journey but they require knowledge of the structure and interactions of the involved biomolecules - most often proteins. In recent years, a tremendous progress has been made in the field of a single protein 3D structure prediction. However, predicting protein assemblies -the most crucial step - still remains very challenging. The aim of this IF project is to revolutionise protein complexes prediction methods. This will be achieved first by developing novel, effective and fast approaches for the calculation of the vibrational entropy, key to protein-protein docking mechanisms. Then, in an innovative and multi-disciplinary approach, the Experienced Researcher (ER) aims to combine advanced physics-based models with machine learning methods using data from structural and sequence databases. Finally, this project will link all the pieces together and release them in the form of a web-server in order to allow the community to benefit from the results of this research. The ER will carry out the fellowship in the Centre National de la Recherche Scientifique - CNRS in Grenoble, France. CNRS carries out research in all scientific fields of knowledge and the Supervisor is a renowned expert in data science, computing, and software engineering. Through a well-thought two-way knowledge transfer and training plan, this project will benefit both the host institution and the ER in terms of scientific knowledge, network and open the path for new applications to potentially exploit at the European or global level. The project will also place the ER as a highly visible researcher in the field and ideally set her as a valuable resource for European industrial actors.

Mots clés : protein protein docking, vibrational entropy, normal mode analysis, geometric machine learning, structural bioinformatics, algorithm development

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 184707.84 €
Projet CBIM (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : SIGNED

Building Information Modelling (BIM) as a product and process enables stakeholders across the built environment sector to create digital versions of real world assets (such as buildings, bridges and tunnels). The digital versions are commonly called 'digital twins'. When placed on the cloud, the digital twins can serve as a resilient and integrated repository of all asset data throughout their life-cycle. Such a repository is a key enabler in this sector of all upcoming IT waves, such as cloud computing, data analytics, participatory sensing, and smart infrastructure. The potential benefits have attracted interest from a wide array of end-users whose interests span from early design phases to operation and asset management, and from roads and bridges to industrial off-shore facilities. This has led to aggressive market penetration in the last decade. However, the full potential of BIM is currently exploited only in a fairly narrow range of applications. This is mainly due to the lack of trained scientific personnel capable of understanding the value of BIM and creating the link between digital twins and possible applications. The ambition of CBIM is therefore to educate researchers in the development of a set of novel and disruptive BIM technologies that will automate the generation and enrichment of digital twins, improve the management, security and resilience of BIM-enabled processes, and boost the industrial uptake of BIM across sectors and disciplines by training these researchers to valorise and exploit their work. This new generation of researchers can play a key role in the widespread implementation of BIM products and processes dedicated to digitising our built infrastructure and managing our assets better to yield massive gains in sustainability, productivity and safety.

Mots clés : building information modelling, industry foundation classes, building data fusion, asset, information modelling, digital twin

Participants :
- Technische Universität Berlin (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 505576.8 €
- Cartif (Espagne) — Partner, beneficiary, Recherche, subvention : 250904.88 €
- Loclab consulting gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 252788.4 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- National University of Ireland (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274684.32 €
- Technion – Israel Institute of Technology (Israël) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 527001.84 €
- Trimble solutions oy (Finlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 561611.52 €
- University of Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 909517.68 €
Projet TLIINCSEFFR (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Building industry is eagerly looking for solutions to save embodied energy and to facilitate the EU’s goal of reducing 80-95% carbon emissions by 2050. However, traditional construction techniques and reinforcement materials limit the geometry and concrete-reinforcement configuration of concrete structures, resulting in almost invariable consumptions of embodied energy produced by concrete elements with a given design capacity. This generates the need for innovative concrete elements with a great potential to save embodied energy. This study proposes 3D GFRP fabric reinforcements capable of being both formworks and reinforcements to construct concrete elements with optimized geometries and concrete-reinforcement configurations, consuming less embodied energy, but having higher material efficiency and lower impact construction. First, experimental tests and numerical analysis will be conducted to achieve desired bond, anchorage and fibre layout properties for fabricating the GFRP reinforcements. Finite element models with the inputs of those properties will be built to predict the stress distribution across non-planer cross section produced by fabric formworks for developing design criteria. Based on the criteria, a numerical code will be developed to achieve the optimal design iteratively. Then, the optimal design will be evaluated with experiments and simulations. Based on experimental and numerical findings, a design criterion will be proposed for 3D GFRP reinforced concrete elements with potentials to reduce material demands and embodied energy up to 40%. The Researcher will bring in the latest updates on adhesive bonds and anchorages as well as Prof. Jirsa’s (ACI President 2000) advice to improve the 3D FRP fabrics proposed by the Supervisor. The fellowship is expected to improve the Researcher’s teaching and research skills with the prospect of serving at a top EU university as a lecturer to lead studies on innovative 3D FRP reinforced concrete structures.

Mots clés : embodied energy, concrete, 3d gfrp fabric reinforcement, higher material efficiency, lower impact construction, bond, anchorage, fibre layout, finite element, optimal design

Participants :
- University of Southampton (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet NHM Night 7 (Horizon 2020, appel à projets 2018)
Action : European Researchers' Night
Statut du projet : CLOSED

Building on our experience in delivering successful European Researchers Nights, the NHM led partnership aims to deliver 12 inspirational events at 6 locations involving 6 partners (3 new to ERN). The collaboration will deliver an extensive impact-rich awareness campaign, which over two years will make over 10 million aware of ERN and its objectives. NHM and 5 subcontractors’ objectives beautifully align with ERN’s: • Increase awareness of the importance of research and innovation to society and our lives now and in the future • Directly engage public audiences with researchers, specifically targeting 18 – 35 yrs • Inspire school students to aspire to a career in science through engagement with researchers demonstrating the variety of exciting careers in science, targeting 11 – 18 yrs • Challenge the perceived stereotype of scientists and their work through awareness • Demonstrate the value of the EU and EU funding structures for collaborative research projects bringing benefit to society • Demonstrate science is an integral part of our culture and heritage An inspirational schools programme, with direct engagement with scientists, targeting those students least likely to engage will open eyes to career opportunities in science. Events will entertain, astound and challenge the 18,000 attending, and will range from dialogue to didactic catering to learning preferences and motivations to attend. Each event will include an EU Corner with assured representation of Horizon 2020 Framework projects and MSCA researchers. Researchers’ will have clear messages to communicate to the audience. They will all receive remote training which will cater for the 500 plus researchers that will be involved in activities, 50 % of which will be female at NHM. In 2018 the museum hosts will connect with European Year of Cultural Heritage. In 2019 Citizen Science will feature heavily in the programme. Evaluation methodology will be shared and results collated by NHM.

Mots clés : target audiences, schools  11, 18 year olds, night  18, 35 year olds

Participants :
- Natural History Museum (Royaume-Uni) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 181194.0 €
Projet ENTOURAGE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

By 2050, two-thirds of the population will live in cities, with people over 65 as the fastest growing cohort. In the EU, their share is projected to increase from 17.5% in 2010 to 29.5% in 2060. At the same time, intense movements of people, vehicles, capital and information challenge the sustainability and social inclusion in cities as they are. Such developments rapidly alter the requirements of currently dominant mobility systems, to cater for the needs of all people visiting or residing in the city. Recent urban transformations are producing new mobility clashes and encounters, which are felt by some groups more than others. Tourist cities are places where such clashes may be most intense and manifold, as they act as visitor hub and home to diverse resident and working populations. Population ageing requires a new understanding of the experiences of urban tourism spaces, at a time when the instability of mainstream city tourism has come to surface. ENTOURAGE unites mobilities, ageing and tourism studies to understand and tackle the negative effects of ‘overtourism’, and instead proposes an ‘age-friendly tourism’. It initiates a data-driven, participatory study with the aim to examine urban mobility transformations in European tourist cities and their effects on the social inclusion of older visitors and residents. The project takes place in the framework of the Age-friendly City, which argues that a focus on the societal needs of older people improves the quality of cities for all. Its interdisciplinary interface promises an innovative combination of qualitative and mobile methods, to capture the age-inclusiveness of urban tourist spaces. It mobilises the knowledge, skills and networks of expert institutions in tourism, urban ageing and smart urban analytics to propose an original combination of resident and visitor perspectives, creating new knowledge about their negotiations of urban quality and conflict.

Mots clés : tourism mobilities, urban geography, mobile methods

Participants :
- Rovira i Virgili University (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet STRATCAT-CO2 (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

By enabling the use of CO2 as a medium for energy storage and as a feedstock for chemical production, the electrochemical reduction of CO2 (eCO2RR) is a potentially transformative technology for the European chemical and energy sectors in view of the European Union’s climate action roadmap. Ethanol and ethylene are high-value eCO2RR products with key roles as a fuel and as a chemical building block, respectively. However, current electrocatalysts are very inefficient in producing these multi-carbon compounds. This action proposes the investigation of an exciting and highly innovative strategy in eCO2RR catalysis—based on functionalizing the catalyst surface with tailored thiol ligands—with a clear potential to overcome the mechanistic hurdles toward C2 product formation. To this end, STRATCAT-CO2 will adopt an interdisciplinary approach combining model catalysts, state-of-the-art characterization, and a close synergy between experimental and theoretical research to gain a mechanistic understanding of surface functionalization that can guide catalyst development. In addition, this action will build bridges between fundamental efforts and electrode and device engineering to achieve breakthrough performance under conditions relevant for practical implementation. STRATCAT-CO2 will provide fresh perspectives in catalyst design for the eCO2RR and, by reaching the foreseen performance targets, set the basis for the development of new electrochemical processes for ethanol and ethylene production. Furthermore, this action will establish an intra-European interdisciplinary network between emerging researchers at DTU and TU Delft. STRATCAT-CO2 will allow the Experienced Researcher to consolidate a diverse set of technical competences uniquely suited for cutting-edge catalysis research, gain skills and credentials in teaching and supervision, and expand his collaboration network, thereby strengthening his career prospects toward achieving research independence.

Mots clés : electrocatalysis

Participants :
- Technical University of Denmark (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 207312.0 €
Projet CIE-NET4DISCHILD (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

By exploring the intersection between disability and childhood issues from a diachronic perspective, this project aims to demonstrate how disability gradually became, between the 1960s and 1980s, a key global issue that must be taken into account in any health and advocacy perspective targeting children. In order to respond to this general objective and thus fill a historical silence, the project studies the Centre international de l'enfance - CIE’s consideration of the needs of children with disabilities by identifying its role and measuring its influence within transnational networks. Created in 1949 by the French paediatrician Robert Debré, the CIE emerged as a major player in the transnational space of advocating for children, playing a complementary role to UNICEF. This project addresses important research gaps by studying the little-known and essential contribution of the Centre international de l'enfance to the development of the North Atlantic modern approach to the rehabilitation of people with disabilities. It fills major gaps in the historiography of children with disabilities in Africa and on the role and exchange of knowledge between CIE experts and local professionals in a de/postcolonial perspective. Through its interdisciplinary research focus and theoretical framework, this project makes an unprecedented contribution to a field of multidisciplinary studies that is still largely unexplored and in full emergence: Francophone studies on disability. Moreover, it aims to document the past of disabled children who have remained largely forgotten and invisible. Revealing the past of disabled children, this research addresses crucial and current questions on care, health issues, social policies for vulnerable populations. Finally, this pioneering project will discuss ethical and delicate issues about discrimination, exclusion or segregation, thus contributing to shape current debates on inclusion of disabled children in European society.

Mots clés : disabled children, disability studies, transnational history, children and youth studies, history of rehabilitation and health, care, gender, post colonial history

Participants :
- Université d'Angers (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196707.84 €
Projet SHINE (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

By only considering the United States of America and Europe, 1 in 12 women is affected by Breast cancer (BC). It is the largest killer in the world among women. The only way to fight BC and overcome it, is by diagnosis at curable stage. Although mammography and alternative techniques can diagnose BC, these tests require specialised laboratories and skilled personnel, and suffer of many drawbacks ranging from limitation of mammography to over 40 to the extremely invasive (painful) tissue biopsies. Moreover, tremendous limitations are encountered in low-resource countries, where the maldistribution of cancer care centers, the scarcity of specialists and financial restrictions don't allow all the women to easily access BC screening tests. The presence of circulating mutations, both DNA and RNA, opens to a cutting-edge opportunity in cancer diagnosis. Detection of mutations in blood, known as liquid biopsy, offers a revolutionary non-invasive procedure for cancer diagnosis. Liquid biopsy has been listed on top of the 10 emerging technologies of 2017, and I intend to develop a novel electrochemical platform that can measure mutations in patient blood with unrivalled accuracy. I will develop a screen-printed electrochemical device capable to read out only the mutated DNA sequences associated with BC. Merging different disciplines (molecular biology, nanomaterials, DNA nanotechnology, printed electronics) SHINE will represent the first BC biopsy-free miniaturised tool allowing BC patients to make a quick clinical decision. Importantly, the development of this miniaturised printed diagnostic platform will allow a sensitive, user-friendly, rapid, equipment-free and low-cost device easily deliverable to those areas where laboratory services and resources are limited.

Mots clés : point of care, self diagnostic, liquid biopsy, breast cancer, screen printed electrodes, paper based device, reagentless, sustainable

Participants :
- Institut Català de Nanociència i Nanotecnologia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €