Projet GlyCoCan (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

Colorectal cancer (CRC) is a major worldwide cancer burden with about 1.4 million cases in 2012 and an annual mortality of approximately 700,000. Early detection is crucial as treatment is most efficient in early stages where population based screenings could substantially reduce incidence and mortality. Current screening techniques are invasive or lack sensitivity and specificity. Moreover, the molecular mechanisms leading to the formation of different antigens suggested as CRC biomarkers and potential therapeutic targets are poorly understood, especially with regard to carbohydrate-based molecules, such as glycans. Enhancing our understanding of the structure-function relationship of glycosylation in CRC could lead to the discovery of improved diagnostic and prognostic biomarkers and pave the way for nov-el therapeutic targets. Building on an established network of analysts with many years of experience in (glyco)proteomics and biomarker research, in collaboration with colleagues in the field of glycobiology and glyco-immunology, GlyCoCan will develop new methods, and use current state of the art methods, to investigate the role of glycosylation in many different aspects of CRC. The GlyCoCan multi-disciplinary network will principally be a training programme with a substantial industrial focus on technology transfer and teaching of internationally adopted biopharma regulations (GMP, ISO9001, ICH guidelines). The underlying specific research objectives will be addressed within individual ESR projects, giving rise to a generation of ESRs whose main focus is investigating and tackling the challenges of the role of glycosylation within CRC and other diseases. The network will address the currently unmet need for glycosylation researchers with an inter-disciplinary perspective to fully exploit the immense potential of the young scientific field of glyco-oncology and to set them on a path to successful and productive careers in academic and industrial collaborations.

Mots clés : colorectal cancer, glycobiology

Participants :
- Leiden University Medical Center (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 628470.95 €
- University of Bologna (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- Max Planck Society (Allemagne) — Partner, beneficiary, Recherche, subvention : 249216.48 €
- Genos (Croatia) (Croatie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 371641.5 €
- Dc4u (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Instituto de Biologia Experimental Tecnológica (Portugal) — Partner, organization partner, Recherche, subvention : 0.0 €
- Roche (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Vrije Universiteit Amsterdam (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255374.28 €
- Postdoc career development forum bv (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Universidade Nova de Lisboa (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Ludger (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 273287.88 €
- Medical University of Vienna (Autriche) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University Hospital Schleswig-Holstein (Allemagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- IPO Porto (Portugal) — Partner, organization partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Universidade Nova de Lisboa (Portugal) — Partner, beneficiary, Recherche, subvention : 476712.72 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 525751.2 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 255374.28 €