Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SOCIETYnext (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

At the dawn of a new decade, fraught with tensions and contradictions, the economic uncertainty hangs over a widespread and acute social inequality, political instability affects vast regions and adds to climatic and environmental emergencies. As a ship caught in a storm, our society needs to find a safe sailing route and hold to it, until calm waters are reached. And as it is the case for sailing, the right direction may be found by looking at the stars, well beyond our everyday horizon. The UN General Assembly provided a useful compass, indicating 17 Sustainable Development Goals to be achieved by 2030 to ensure Prosperity and Peace for People and the Planet thanks to a global Partnership. The SDGs reflect the major global issues, from poverty to health care, from quality education to gender equality, from clean energy to sustainable economic growth, from climate change to environmental degradation. The European Researchers’ Night 2020 organized by SOCIETYnext will show that researchers are among those whose everyday work addresses these challenges. Far from hiding in an ivory tower, researchers are deeply rooted in reality and well aware of its complexities, which so often constitute the very subject of their research. From the early warnings about climate change to the development of strategies for a fair and safe evolution of our society, researchers intervene often in the public debate. When the youth floods the streets of our cities with their worries about the future, it is time for science and research to provide their insights on the great issues of sustainable development. To respond to this societal demand, along with classic edutainment, meant to amuse the public, SOCIETYnext will offer various opportunities for serious discussions about complex issues with competent researchers, engaging participants in a two-way dialogue about priorities and needs that society should address to ensure a sustainable future.

Mots clés : public engagement, event, dissemination, cultural heritage, schools, young people, edutainment, gender balance

Participants :
- Istituto Nazionale di Geofisica e Vulcanologia (Italie) — Partner, beneficiary, Recherche, subvention : 8797.5 €
- National Institute for Nuclear Physics (Italie) — Partner, beneficiary, Recherche, subvention : 4236.25 €
- University of Bologna (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 45731.25 €
- Cineca (Italie) — Coordinator, beneficiary, Recherche, subvention : 27500.0 €
- Comunicamente srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 96250.0 €
- National Research Council (Italie) — Partner, beneficiary, Recherche, subvention : 10937.5 €
- National Institute for Astrophysics (Italie) — Partner, beneficiary, Recherche, subvention : 4815.0 €
Projet MARGINS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

At the end of the Near Eastern neolithization process (PPNC-Late Neolithic, 7th-6th millennium), a wide conquest of arid margins occurred while large villages collapsed in the Fertile Crescent. Early hypotheses posited that population movements reflected demographic pressure and took place from the western greener valleys to eastern steppes. Despite a nowadays agreement on more dynamic processes of multi-directional cultural interchanges, the complexity of this wide phenomenon remains to be understood. To achieve this goal and thanks to an integrative approach, MARGINS aims to propose renewed scenarios of ‘conquest’ and to clarify its factors of influence, in particular the respective impacts of environmental components and socio-economic choices. To do so, the project will investigate settlement patterns and land use through subsistence activities and their adaptations to constraints of arid contexts. As an impetus for the project, I question in particular the role of the pastoral nomadism, later considered as a marginal way of life, as a central driving force for this sustainable occupation of arid lands, and the status of the Syrian steppes as a cradle for the conquest towards the south, in Jordan. The project will rely for the first time for the period and region under study on a multi-scalar and diachronic approach of socio-economic mechanisms implemented thanks to quantitative and spatial analyses with the help of statistics, GIS and remote sensing technics. MARGINS will break through barriers that have prevented a “big picture approach” of the Neolithic ‘conquest’ of near eastern arid lands by bringing together an unprecedented combination of methods, interdisciplinary specialists and renown international institutions – the CNRS research unit CEPAM in France and the Oriental Institute of the University of Chicago in the USA – involved in the processing of the largest set of raw archaeological data gathered both in Syria and in Jordan in the past 50 years.

Mots clés : neolithic, near east, arid margins, statistical analysis, remote sensing, landscape study, spatial archaeology, human land relationship, settlement patterns, territorial organisation

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 275619.84 €
- University of Chicago (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SuperSpinHyMol (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

At the intersection of materials science, solid-state physics and quantum chemistry, the design of novel materials in which two or more physical properties are combined into the same solid is currently attracting important attention. In this project, we propose the development of a new generation of hybrid molecular/two-dimensional materials formed by a coordination complex processed into a two-dimensional superconducting substrate (e.g. CuPc@NbSe2 or [V(C3S5)3]@TaS2). The selected molecules to form such architectures are nanomagnets that can be used as molecular spin qubits, the irreducible components of any quantum technology. By using state-of-the-art first-principles methods combined with recent theoretical developments in the host group we intend to establish a full theoretical and computational framework for the rational design of these new hybrid nanomaterials, which can potentially enable the coherent coupling between distant molecular spin qubits through new superconducting phases. With this aim in mind, we will simulate their electronic properties in the normal and superconducting phase, as well as the spin-related effects that will take place due to the interplay between molecular magnetism and superconductivity at the nanometre scale. SuperSpinHyMol will be hosted by a leading expert in the field, Prof. Ángel Rubio, director of the MPSD (Germany) and will also involve collaboration with top international experimental groups, which will fabricate and characterise the proposed materials. Thus, the theoretical results of this project will be benchmarked against high-resolution experiments and refined when necessary. In the long-term, the progress of this project is expected to have profound impacts on materials science, condensed matter physics, as well as molecular magnetism, providing the foundations to guide the design of new nanodevices using chemical engineering for future advances in quantum computing and molecular spintronics.

Mots clés : molecular magnetism, quantum computing, first principles calculations, 2d layered materials, transition metal dichalcogenides, hybrid inorganic, organic materials

Participants :
- Max Planck Society (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 159460.8 €
Projet Athenea3I (Horizon 2020, appel à projets 2016)
Action : Cofund Postdoctoral programme
Statut du projet : CLOSED

Athenea3I is an innovative regional wake-up call focused on attracting highly talented researchers to Granada (Andalusia region, Spain) in order to benefit their research career with International, Interdisciplinary and Intersectorial opportunities. This innovative fellowship programme offers the experienced researchers an outstanding opportunity to develop new skills and competences, enriched with a personalized and pioneering career mentoring plan. It also includes research periods at some of the most distinguished outstanding institutions around the world, and optional secondments in regional, national and international companies. The high-talented human capital hired by the University of Granada, as beneficiary institution, will perform as active “magnets” in relation not only to academy, but to industry and business, establishing bridges for transfer of knowledge, exploitation of the results, and future research collaborations. Athenea3I commitment pivots on the applicability of the research outputs by making Science for Society: reinforcing not only the innovation aspect but also the open data access and the public engagement. It has on target the social challenges of Andalucia2020, shooting up their results to palliate some socio-economic problems of the region and, consequently, to get towards the Europe2020 targets.

Mots clés : triple i, talent mobility, networking, er mentoring, research carreer development, innovation, regional weak up call

Participants :
- University of Granada (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 2124000.0 €
Projet Athero MPh proliferation (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Atherosclerosis is a slowly progressing inflammatory disease that underlies some of the most common causes of death in western society. The central role of macrophages throughout its pathogenesis makes this cell an eminent target for therapeutic intervention. Recent studies have subverted the classical view that atherosclerotic plaque macrophages mainly originate from recruited circulating monocytes, launching the new notion that macrophages could also be derived from clonal expansion of resident macrophages or even trans-differentiated vascular smooth muscle cells. The relative importance of these mechanisms to the pathogenesis remains however unclear, due to a lack of adequate animal models that allow assessing this question. In this project, I introduce a recently developed fate mapping model, the LysMCre-Ubow+/+ mouse, into the atherosclerosis field to conclusively identify regions within the plaque that were formed through local proliferation rather than monocyte recruitment. Apart from quantifying its relative contribution to plaque growth during disease progression and regression, I will furthermore characterize the localization, transcriptional activity and the lipidic makeup of these proliferated cells versus invaded monocytes. In a second part of this project, I will deploy adoptive bone marrow transfers from WT to Ubow mice and vice versa as a model to quantify intraplaque myeloid versus stromal-cell derived macrophages. I will compare proliferative capacity, phenotype, transcriptomics and lipidomics of these two subsets and link this information to their functionality. With this strategy I will be the first to reveal the impact of the three macrophage accumulation mechanisms throughout the disease course, to couple this to their function and to exploit this knowledge for targeted experimental therapeutic interventions.

Mots clés : proliferation, ontogeny

Participants :
- Maastricht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet ANOXIA-MEM (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Atmospheric anoxia prevailed throughout the majority of Earth history, making oxygen and the animal life it supports relative newcomers to our planet. O2 accumulated in Earth’s atmosphere during two dramatic oxygenation events at ~2400 and ~600 million years ago (Ma). Both of these events were accompanied by profound biological and geochemical revolution, including the origin of animal life, making them amongst the most important events the Earth system has ever witnessed. Because the composition of Earth’s ancient atmosphere cannot be measured directly, its history must be examined using models constrained by geochemical proxies. The disappearance of sulfur isotope mass-independent fractionation (S-MIF) from the sedimentary record ca. 2320 Ma is considered the “smoking gun” evidence for the permanent oxygenation of Earth’s atmosphere. However, it was recently suggested that weathering of older S-MIF bearing sediments resulted in a prolonged S-MIF “memory effect” that lasted ~200 Ma or more, thus obscuring the true history of atmospheric oxygenation. Here I propose new hypotheses to test, for the first time, the importance of the S-MIF memory effect at the onset of atmospheric oxygenation. I will evaluate specific sulfur, strontium, and oxygen isotope signals from exciting new samples obtained through a recent French drilling program to help resolve this fundamental problem in Earth system evolution. As an American Experienced Researcher, this Marie Curie project, ANOXIA-MEM, is designed to harmonize my unique isotope geochemistry skills with the knowledge, resources, and training capacity of two renowned French isotope laboratories for the maximum benefit of all parties. This project promises new tools and analyses that are uniquely poised to upset the prevailing paradigm for Earth’s atmospheric oxygenation.

Mots clés : great oxidation event, multiple sulfur isotopes, multiple oxygen isotopes, stable isotope geochemistry

Participants :
- Université de Brest (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet ADBCRZB (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Atmospheric carbon dioxide (CO2) has increased from 278 to 415 ppm over the industrial period and has critically impacted climate change. Coupling CO2 utilisation with electrochemical energy storage devices, such as metal‐CO2 batteries, represents a promising clean strategy to deal with greenhouse gas effect and energy dilemma simultaneously. We propose to develop an aqueous Zn-CO2 battery prototype based on CO2-HCOOH conversion for high-efficiency energy storage. To achieve this goal, bifunctional Pd-based single-atom catalyst cathodes will be exploited to drive CO2 conversion with high activity and selectivity. We will then probe the reaction mechanism of catalysts by operando analytical tools together with density functional simulations. Moreover, bipolar membrane, gas diffusion electrode, and ionic liquids will be used as alternative approaches to enhance the Zn-CO2 battery performance at cell level. This project is expected to make a significant step forward in the exploitation of single-atom catalysts for CO2 conversion, and accelerate the development of emerging Zn-CO2 batteries. The project also includes a comprehensive training program to enhance the future career prospects of the fellow.


Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203149.44 €
Projet ACRoNNIM (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Atmospheric particulate matter reduces visibility, adversely affects human health and impacts Earth’s climate. Recent laboratory research has identified NH3 as a potentially important reactive species in the formation and aging of SOA, a significant but not-well-quantified class of aerosol particles. The goal of this proposal is to answer the questions: How does NH3 affect aerosol mass loadings and optical properties on a global scale? And, what impact do these effects have on air quality and climate? This will be accomplished by incorporating NH3-related SOA chemistry, currently being investigated by collaborators at the University of California, Irvine (UCI) into the state-of-the-art CACM/MPMPO SOA module. The updated module will be deployed in the NMMB/BSC global chemical weather model, maintained at the Barcelona Supercomputing Center (BSC). Model predictions will be validated by field measurements collected during an IDAEA-CSIC campaign that the experienced researcher (ER) will participate in, as part of this proposal. This will result in one of the most advanced SOA treatments available in global models, and allow an investigation of the impact of NH3 on global SOA, air quality and climate, thus directly impacting a crosscutting issue of the Horizon 2020 Program, climate action. The ER has experience using laboratory results to develop mechanisms for aerosol processes, and in the development of CACM/MPMPO as a graduate and postdoctoral researcher at UCI. This experience, coupled with training in global model development at BSC, will provide ideal conditions to successfully execute this proposal, and strengthen the collaboration between the European BSC and IDAEA-CSIC, and US-based UCI teams. By the end of the Fellowship, the ER will have hands-on experience in field, laboratory and computational aerosol research, uniquely positioning him to develop and carry out comprehensive, collaborative research initiatives and opening up improved career opportunities.

Mots clés : secondary organic aerosol, ammonia, atmosphere, global model, nmmb, cacm, mpmpo

Participants :
- Barcelona Supercomputing Center (Espagne) — Coordinator, beneficiary, Recherche, subvention : 170121.6 €
Projet AFIBROTIC (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Atrial fibrillation (AF) is the most common type of arrhythmia and causes substantial morbidity and mortality. AF is principally treated with catheter ablation. Unfortunately, the mechanisms that initiate and sustain the arrhythmia are still incompletely understood and, as such, ablation remains a highly operator-dependent procedure with low success rates. Two recent studies promise to lead to better ablation outcomes, showing that a) the amount of atrial fibrosis directly correlates with the non-responsiveness to ablation and that b) AF is maintained by electrical rotors and targeting their suppression improves the success rates. Nonetheless, the lack of a rigorous mechanistic framework of AF pathophysiology deprives those studies of solid fundaments so that their effective value is still debated. This project aims therefore to provide such a framework by exploiting advanced biomedical engineering concepts. The focus will be on explaining and connecting recent experimental findings about fibrosis and rotors. The relationship will be first analyzed in vivo from AF patient data acquired with state-of-the-art instrumentation in the field of interventional electrophysiology. Measured data will be then integrated within a multi-scale personalized computational model of the fibrillating atrium that will determine, on a patient-specific basis, the mechanistic connection between fibrosis and reentries. Furthermore, the tool will provide an in silico environment for personalized ablation planning. Key in the project will be the synergy between complementary state-of-the-art expertise in the fields of medical imaging and computational modeling provided by applicant and host institutions. All partners will strongly benefit from the implied two way knowledge transfer, in terms of career advancement (the applicant) and enlarged network/grant proposal opportunities. The study will foster more focused clinical research aiming at better treatment for the AF patients.

Mots clés : atrial fibrillation, catheter ablation, procedure planning, computational modeling, patient specific, in silico medicine, fibrosis, reentrant circuits

Participants :
- University of Bologna (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 168277.2 €
Projet ADHDLightUp (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Attention-deficit/hyperactivity disorder (ADHD) like many other mental illnesses probably results from a combination of genetic and developmental factors pointing at abnormalities in brain monoamines (MA). Imaging studies in ADHD patients also indicate deficits in activity of various brain regions including the prefrontal cortex (PFC) and basal ganglia (BG). The mechanisms by which PFC and BG dysfunctions are triggered, and can be corrected with MA-based treatment are unknown. Although there is a consistent frontal hypoactivity detected in ADHD, some variations are seen amongst executive processes including attention or impulse control, in which MA have specific functions. Besides, the limited spatial resolution of brain imaging does not allow to detect certain subregions or discriminate neuronal subpopulations. In order to identify brain network impairments in ADHD, we need models to further dissect frontal dysfunctions looking at MA signaling, cell excitability and behavioral correlates of activity in identified neurons. The goal of this project is to untangle brain circuits involved in a novel mouse model of ADHD, which fulfills the major criteria reflecting human condition, showing specific BG dysfunctions and differential MA involvement. Innovative approaches have been chosen to accomplish this challenge that include transgenesis, opto- and pharmaco-genetics, and in vivo measurement of neuronal activity in translational behavioral tasks assessing attention and impulsivity. Importantly, while the most common medication using psychotimulants has proven the best efficiency, it has also been shown to affect children growth and their adult mental health highlighting the urge for alternatives. We believe that our model and multidisciplinary methodology provide new insights in ADHD ætiology and allow to develop new concepts and/or targets for therapeutic alternatives further based on the manipulation of neurons activity to reverse or attenuate ADHD symptoms.

Mots clés : attention deficit, hyperactivity disorder  adhd, impulsivity, monoamines, striatum, prefrontal, cortex, optogenetics

Participants :
- Université Libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172800.0 €