Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet COUPCAT (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Biomass-derived molecules contain excess oxygen that must be removed to render as fuel or chemicals. Due to feedstock fluctuations, ethanol and ethene are becoming key components to overcome these challenges. Given the current bioethanol (fermentation) and ethene (crackers) excess, and the propene shortage in Europe, alternative routes are required. During the outgoing phase under the supervision of Prof. Iglesia at UC Berkeley (USA), the researcher Dr. Iker Agirrezabal-Telleria will address the fundamental mechanistic aspects of dimerisation and metathesis reactions from ethanol to propene operating at low-temperature and studying the individual parameters using multidisciplinary approaches. This will include spectroscopic (in-situ UV-VIS and FTIR ) and isotopic techniques to elucidate the contribution and role of active metals for dimerisation (Ni), isomerisation (H+) and metathesis (Re, Mo). The optimised catalysts will be tested during the return phase under the supervision of Prof. Arias at the University of the Basque Country (Spain) using engineering approaches. Catalyst slurry and formulations will be prepared to test them on microreactor systems. The microreactors will be coated during a secondment period under the supervision of Prof. Kolb at Fraunhofer ICT-IMM (Germany). This phase aims to achieve process intensification and reduce heat-transfer issues occurring in packed-bed reactors. The comparison between fixed-bed and microreactors will enable to obtain interdisciplinary inputs to produce propene from ethanol. This Fellowship aims to carry out cutting-edge scientific training and transferable skill training such as project management, relevant for the re-integration period and to become an independent research leader in Europe. Moreover, this projects aims to have a positive impact on European society and competitiveness. These actions will involve outreach activities, results dissemination and IPR management.


Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of the Basque Country (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 257191.2 €
Projet GelPrint (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Biomaterials with antimicrobial properties which can be used for wound healing and tissue engineering applications offer high application potential due to the global increase of antimicrobial resistance. While polypeptides own this potential, their integration into a materials platform has not been realised to date. The overall objective of this project is to develop 3D printable antimicrobial or bacteriostatic polypeptide hydrogel materials, which can be employed in tissue regeneration applications to prevent bacterial growth. In particular, the goals include synthesis of sets of cross-linked polypeptide hydrogels based on lysine (Lys) and investigation of their hydrogel properties and 3D printability. Moreover, evaluation, validation and quantification of the antimicrobial properties of the hydrogels as well as the proof of concept demonstration for their feasibility in tissue regeneration will be addressed. The synthesis of these particular copolypeptides hydrogels is highly novel and their exploitation as a printable tissue regenerating platform is timely, of high fundamental as well as clinical impact and considered a new approach. The proposed project is broadly interdisciplinary, as disciplines of polymer chemistry, biomaterials science and engineering, microbiology and in vitro assessment techniques will be combined. The high-level science combined with complementary training will significantly advance the career opportunities of the applicant. Moreover, the excellent match of the applicant`s expertise with the project and the host organisation will ensure a strong transfer of knowledge between all participants. The potential of the proposed project is further highlighted by the possible commercial exploitation of the scientific findings and developments. Finally, it will enable new collaboration opportunities between research groups from different scientific fields.

Mots clés : polypeptides, antimicrobial hydrogels, 3d printing, tissue regeneration

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184590.72 €
Projet BioResORGEL (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Bioresorbable bioelectronics aim to produce technologies that monitor/modulate biological functions and safely integrate into life and the environment. It prospects to eliminate the need for bioelectronic implants retrieval and to produce zero waste solutions for consumer electronics. The integration of degradable substrates with water-soluble electronic components (metals and semiconductors) led to the first examples of bioresorbable electronic implants. A key challenge is to develop devices combining high performance, stable operation, and controlled degradation at the end of their life cycle. Current hydrolysable materials suffer from inadequate lifetime, uncontrolled bulk degradation, and/or poor performance. Advanced bioresorbable microelectronics would require components that degrade in biological environments by the action of enzymes – something that cannot be achieved with conventional metal-oxide semiconductors. Conjugated polymers offer transport of both ions and electrons, low operating voltages, and flexibility – features exploited to improve state-of-the-art bioelectronic devices and interfaces – and, most importantly, the potential to undergo enzymatic breakdown. Yet, there is currently no example of a conjugated polymer and device thereof combining all the required properties. This project develops the first example of bioresorbable organic bioelectronic devices that are degraded in situ by the action of specific enzymes. It integrates aspects from materials chemistry (polymer design), organic electronics (device design), and cellular biology (biodegradation and toxicity). Key focus is to integrate device components that provide high performance and that are eroded by enzymes normally secreted by immune cells during inflammation and tissue regeneration. This interdisciplinary approach suggests a promising future across different fields – from fundamental aspects of polymers degradation and toxicity to the next generation bioelectronic interfaces.

Mots clés : organic bioelectronics, bioresorbable electronics, conjugated polymer, organic electrochemical transistor, enzymatic degradation, biodegradable conjugated polymer

Participants :
- KTH Royal Institute of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203852.16 €
Projet POLE2POLE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Bipolarity, or the presence of the same species in both polar regions, has intrigued the scientific community over centuries. Almost the entire tree of life taxa, from microbes to whales, are known to include some bipolar representatives inhabiting the Arctic and the Antarctic. However, our knowledge on the evolutionary origin and consequences of bipolarity are still fragmentary. POLE2POLE will focus on Hydrozoa (Cnidaria) as a model group to unveil bipolarity patterns and processes with a multi-scale methodology. Given their ubiquity and the wide array of life cycle strategies, hydrozoans constitutes the ideal system to asses this natural phenomenon, enabling a comparative approach. I will first perform an integrative species delimitation on selected hydrozoan taxa representing major ecological and life cycle strategies. I will then reconstruct the evolutionary history of the selected cases by means of High-Throughput Sequencing techniques. Time of divergence and character evolution will be subsequently estimated for the taxa analysed. The project will allow to determine if the divergences took place during an interglacial period or during a glacial maxima, and therefore if vicariance and/or dispersal respectively shaped the current distribution of bipolar hydrozoans, and if previous hypothesis on the presence of relict taxa can be corroborated. Furthermore, POLE2POLE will allow to study in an unprecedented way if life cycle strategies and their corresponding dispersal capabilities are linked with time of bipolar divergence. Thus, through POLE2POLE, I will develop a novel transversal and interdisciplinary framework to study the origin and diversification of the biota inhabiting polar regions, and a model system for speciation processes over oceanic scale. The project will be implemented at University Museum of Bergen (UMB-UiB) under the supervision of Dr Aino Hosia.

Mots clés : hydrozoa, hydroids, hydromedusae, jellyfish, speciation, cryptic species, species complex, evolution, divergence time, phylogeography, vicariance, dispersal, biogeography, arctic, antarctic, polar

Participants :
- University of Bergen (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 303238.08 €
Projet BFO-Surf (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Bismuth ferrite (BFO) is one of the few multiferroic materials at room temperature. It is of interest for use in memory elements, spintronic and photovoltaic systems, to name but a few. In all applications, the use of BFO thin films and nanoparticles is being greatly investigated, due to their greater fatigue resistance and larger polarization at modest electric fields with respect to the bulk. However, reducing the dimensionality of BFO can lead to surprising and so far unexplained behaviour. For example, recent experiments have reported the existence of a surface “skin” above bulk-truncated BFO, with different lattice parameters and phase transitions than the underlying bulk. This surface skin layer exhibits strikingly different properties from the bulk, since it is ferroelastically and ferroelectrically dead. It is thus of paramount importance, for practical applications of BFO, to understand how 2D structures (like thin films) and 1D structures (like nanocrystals) differ in their multiferroic behaviour from the relatively well understood bulk phase. Since surfaces are dominant in these two classes of systems, a good atomistic understanding of low-energy surfaces and their stability in the environment is needed. Thus, we propose a two-year project with the overall aim of studying the atomistic structure and the magnetic and polarization properties of BFO thin films and nanocrystals using using ab initio methods (density functional theory with ab initio thermodynamics).

Mots clés : multiferroics, surfaces, nanocrystals, ab initio thermodynamics

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187419.6 €
Projet WMBH (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Black holes are among the most fascinating objects of the Universe. They are today at the core of our understanding of gravitation. They provide essential hints towards a theory of quantum gravity. They constitute the main emission source of gravitational waves, which will play a central role in future astrophysics. Black holes are also central in mathematical relativity, and the proof of their stability is still today a challenging problem. In the last decades, several analogies between gravity and fluid mechanics have been developed. This interdisciplinary approach has led to many innovative methods and successful results, which have deepened our understanding of black holes, fluids or superfluids. More recently, such an analogy was used by various experimental groups, which were able to successfully reproduce several key effects of black hole physics using fluid systems. The aim of this project is to develop the mathematical tools to open a new avenue in this interdisciplinary field: the understanding of nonlinear dynamics. In other words, how waves are affected by a background flow or spacetime, and subsequently modify their dynamics. It will focus on three research directions: the analogue of the Hawking effect, superradiant instabilities, and resonances. This project will bring an experienced researcher in analogue models in a strong mathematical physics group, within the Institute of Mathematics of Burgundy (IMB). The objective is to exploit modern mathematics to develop new tools for the joint analysis of black holes and fluids. It will rely on the one hand on mathematical methods of integrable models, and spectral theory of non self-adjoint operators, two fields in which the host group has a traditionally strong expertise, and on the other hand on the knowledge in General Relativity and analogue models of the experienced researcher.

Mots clés : general relativity, black holes, wave flow interactions, partial differential equations, integrable models, spectral theory

Participants :
- Université Marie et Louis Pasteur (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196707.84 €
Projet cmiRCan (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Blood-based cancer biomarkers have become important research targets and together with the recent development of liquid biopsy methods and analysis, they have become interesting future tools for cancer diagnosis. The cell-free small non-coding circulating RNA particles, namely microRNAs (c-miRs) that associate with cancer development, have been identified and tested to be used for cancer screening, diagnosis, tumor subtype classification, chemo- or radio-resistance monitoring, and outcome prognosis. Here we use whole serum c-miR clusters from patients with hereditary cancer syndrome, called Lynch syndrome, as a biomarker and we develop machine learning-based algorithms to diagnose and predict cancer occurrence in this patient cohort. We also functionally test how these c-miR clusters effect lynch syndrome linked to tumor growth. This interdisciplinary project combines clinical, cell biological and bioinformatic research and it will reciprocally transfer knowledge between research, Tiina Jokela and host institute, University of Jyväskylä and secondment institutes; University of Helsinki and Helsinki University Hospital. The proposed project support researcher Tiina Jokela to also gain transferable independent research skills and support her future career goal to become the leader of her own academic research group in the cancer research field.

Mots clés : c mir, mirna, lynch syndrome, machine learning, patient derived organoids

Participants :
- University of Jyväskylä (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202680.96 €
Projet RejuvenateBone (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Bone defects resulting from trauma, tumor resection and bone diseases represent one of the most pressing health problems in the aging European population. Current treatments of bone defects depend on a functional population of bone-forming (osteogenic cells) to mediate the process of bone regeneration. However during aging, the bone formation capacity decreases as a result of multiple interacting cell-intrinsic and cell-extrinsic mechanisms and the success of treatments in aged patients is in most cases limited. The aim of our project is to develop a new multidisciplinary approach to enhance the regeneration of bone defects in elderly, based on recent advances in cellular reprogramming and tissue engineering. We propose to investigate the extrinsic microenvironment components synthesized by young, embryonic-like osteogenic cells derived from human induced pluripotent stem cells, and test their potential to enhance the function of endogenous bone and vascular cells. We will focus our studies on the patients unable to benefit from the current therapies, due to advanced age and/or systemic conditions limiting their bone formation capacity. We will develop allogeneic, off-the-shelf bone tissue substitutes with the capacity to enhance the function of endogenous cell populations, and evaluate their safety and bone healing potential in preclinical models of bone repair. We hypothesize that ostegenic cells derived from reprogrammed adult/aged somatic cells can synthesize a “rejuvenated”, embryonic-like bone microenvironment with high regenerative capacity and enhance the bone healing processes mediated by aged endogenous cell populations. Our studies will provide new understanding of extrinsic mechanisms governing bone cell biology during aging and open new therapeutic possibilities for the aged patients currently lacking successful outcomes. The developed bone substitutes will also provide a valuable new model for basic biology studies and translational research.


Participants :
- Ludwig Boltzmann Gesellschaft (Autriche) — Coordinator, beneficiary, Recherche, subvention : 178156.8 €
Projet miROMeS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Bone metastasis is a common complication for breast cancer patients, affecting 70% of patients diagnosed at advanced stages. Blood-based microRNAs (miRNAs) have received considerable research interest as biomarkers in cancer. The identification of biomarkers predictive of bone metastasis may be useful for the administration of preventative drugs such as bisphosphonates. In this study, a large-scale screening analysis of > 700 miRNAs will be performed in serum from breast cancer patients with and without visceral or bone metastasis. We will further evaluate candidate miRNAs using serum samples from a second cohort of breast cancer patients who were examined prospectively (with 8 years of follow-up) for relapses in bone and non-bone sites. At this stage, we anticipate the identification of a miRNA signature predictive of bone metastasis in patients with early-stage breast cancer. The second part of this study will assess the role of these miRNAs in the tumour-bone microenvironment. Circulating miRNAs may derive from bone cells or the tumour, and may enter the circulation through cell-derived vesicles called exosomes. We will study the biological functions of miRNAs dysregulated in patient serum. Overlaps between miRNAs in the serum and exosomal miRNAs that are derived from tumour cells or osteoclasts will be further assessed using in vitro and in vivo models of bone metastasis. By studying the activities of these exosomal miRNAs in the bone microenvironment, we may be able to better understand bone metastasis as well as identify new miRNA-based therapeutic targets.

Mots clés : mirna, biomarker, serum, exosomes, bone metastasis, breast cancer, metastasis

Participants :
- Université Claude Bernard - Lyon 1 (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet CfACTs (Horizon 2020, appel à projets 2019)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

Bournemouth University (BU) will host CfACTs as a MSCA COFUND research training centre for experienced researchers (ERs), providing the international mobility and cross-sectoral experience through the well-aligned training and research programme. With the ERs’ research and innovation development on their chosen topics, it will bring significant change to the technological landscape by adopting novel creative technologies into various applications to promote well-beings and innovations. CfACTs will operate from 1 Oct 2020 to 30 Sep 2025to host 6 MSCA ERs (CfACTs ERs hereon). These CfACTs ERs will be recruited in two cohorts during the period 2020 to 2023. The 6 CfACTs ERs will be full-time academic employees of BU, and embark on a two year programme of world leading digital creative technology research and training provided by CfACTs, and its Partner Organisations (POs, e.g. Sony, Emteq). Each CfACTs ER will have an opportunity to be seconded into one or more POs for the majority of their two year programme with full academic support to gain cross-sectoral experience. The CfACTs ERs will research and develop new applied digital creative techniques, collaboratively with industry POs; and apply them cross-sectorally for various applications including but not limited to, computer animation, visual effects (VFX), computer vision, visualisation, healthcare, retail and assistive technology. These new techniques will also bring important productivity improvements to many industries. The BU academic expertise underpinning CfACTs is sourced from BU’s world-class National Centre for Computer Animation (NCCA) and as required, other BU centres of research excellence, including: Centre for Games and Music Research; the Orthopaedic Research Institute; the Centre for Archaeology and Anthropology, and the Institute of Medical Imaging and Visualisation.

Mots clés : creative technologies, digital creation, computer animation, visual effects, computer vision, machine learning, artificial inelegance, medical simulation and visualisation, assistive technology

Participants :
- Bournemouth University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 441360.0 €