Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Neuralase (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Summary Nanolasers offer the ultimate photonic gadget with unique properties as biosensors and actuators. Lasers at the nanoscale can concentrate high optical powers in small volumes and use a fraction of the power required to drive a conventional laser. Recently, nanolasers and nanoresonators have seen use for biosensing, with the focus so far on in-vitro biochemistry. Translating this approach to in-vivo is complex but promises to link relevant in-vivo physiological information with chemical pathways. This project aims to integrate photonic architectures for in-vivo deep-tissue exploration and to translate this technology to areas where probing the local environment with light has an immediate impact, such as the Brain. My proposed research thus bridges different scientific disciplines exploring the physics of biological sensing. I foresee 3 major efforts to succeed in this research: 1 – Design of micro- and nanocavities operating in the IR. 2 – In vitro characterization through highly scattering media. 3 – In vivo investigations for deep-tissue sensing.

Mots clés : intracellular laser, upconversion, nanolaser, deep tissue, sensing, neural probe

Participants :
- University of Cologne (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 174806.4 €
Projet Taxol biosynthesis (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Summary We propose to biosynthesis de novo of fungal taxol® production by the regulation of transcription factors (TFs). However, such a scenario is not yet to be investigated in case of taxol-producing endophytic fungi. The principle aim of this project is to isolate TFs genes WRKY, AP2, MYP etc. that specifically regulate the expression of taxol biosynthetic rate limiting gene promoters using transient RNAi. The attractive features of this study, examining the elicitor-induced regulator of selected TFs genes to see whether their mRNA levels correlate with fungal taxol biosynthesis. In order to identify key regulators of taxol pathway, cDNAs will be explore to obtain the recombinant TF protein. This project offer de nova interactions between the TFs and the TB gene promoters, which results of DNA binding cis-elements. It can be exploited to produce superior increased taxol yields from wild or transgenic fungi. This programme of work will provide a new strategy for unlocking the full potential of fungal biotechnology at the interface with metabolic engineering and rDNA technology to establish of fungal fermentation through genetic engineering approaches. The complementary expertise of Dr Kamal (Fungal biotechnology) and the supervisor Prof. Dr. Frank Kempken (FK) (Fungal genetic and molecular biology) offer the unique combination to realize the fungal taxol biosynthetic potential. Overall, this research will lead to a comprehensive understanding of the key TFs that control elicitor induced metabolic changes to produce highest yield of fungal taxol and will provide intellectual property (IP), technology development, which lead to Dr. Kamal with new and cutting-edge research training.

Mots clés : taxol biosynthesis, transcription factors, elicitor, endophytic fungi

Participants :
- Kiel University (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 174806.4 €
Projet BEND (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Summary of Marie Curie Proposal for H2020-MSCA-IF-2015 “Bendable Bioplatform for Electrically stimulated Neuronal Differentiation” With western countries aging faster, the neurodegenerative diseases like Parkinson’s, Alzheimer’s, Huntington’s etc. pose serious threat to quality of life, especially for people over 65 years[1]. In Europe, number of people suffering with dementia, which results from neuronal degeneration, is on the rise it is expected to be double in the next 20 Years[2]. The neuronal degeneration is irreversible[3] and currently the cell therapy for regeneration of neuron network is the only option to compensate such a loss. Recently, the induced pluripotent stem cell (iPSC) derived NSC therapy has come up as an excellent opportunity in treating of neuro degenerative diseases. However, proliferation and differentiation of iPS cell population in neuronal replacement therapies poses many technical challenges such as targeted neurite differentiation to compensate desired loss with controlled differentiation[4]. Traditionally, the neuronal differentiation of iPSC is performed using several transcriptional and growth factors, which are complex, expensive and non-scalable processes[5]. For this reason, the research for a simple, robust and scalable method for generating large number of mature, differentiated neuronal cell deserves top priority. In addition, an accurate on/off system for scalable proliferation and neuronal differentiation is pivotal for the development of implantable bioelectronics circuit suitable for in vivo application. It is believed that the electrical stimulus controlled neuronal differentiation of stem cells on a soft, bendable electro conductive substrate can be suitable for bioelectronics application and also for compensating neuronal loss in the degenerative disease or injuries. This project is an ambitious endeavour in this direction. A bendable bioplatform will be developed for electrically stimulated neural differentiation t

Mots clés : bendable bioplatform, electrical simulation, neuronal differentiation, nanoscale pattern, rgd peptide

Participants :
- University of Glasgow (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet RESOLVE (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Sun-like stars possess magnetically confined, upper atmospheres. These coronae have temperatures of several million degrees and thus are much hotter than the underlying stellar surfaces (photospheres) which have temperatures of the order of 6000 degrees. The coronae are hotter than the photospheres because magnetic energy is generated by convective motions beneath the stellar surface and then transported through the photosphere into the corona where it is dissipated. The key to understanding the heating of the corona is to determine how, and at which spatial and temporal scales, energy is being transported into the stellar atmosphere. Both theory and simulations suggest that a substantial fraction of the energy transfer happens at spatial scales smaller than those currently observationally resolvable. The main goal of the proposed research is to bridge this gap between what we expect from theory and what we can observe. The proposed research will use numerical simulations to characterize the energy flux and look for its (spectropolarimetric) signature. This signature will then be used to create maps of the energy flux on the actual Sun using the highest-resolution observations (50-70 km) which are available: those from the 1-meter Sunrise balloon-borne observatory, and the 1.5-meter GREGOR, Europe's largest solar telescope. We will validate the diagnostics by comparing these maps of the observed energy flux into the solar atmosphere with co-spatial observations of the hot plasma structures seen in the upper atmosphere. Understanding the energy transfer combines the strengths of advanced simulations and the unprecedented observations as well as combining the expertise of world-leading solar groups in Germany and Spain. This research will have a major impact on our understanding of the heating of upper atmosphere. It is the ideal project and set of collaborations to further the experienced researcher's scientific career.

Mots clés : astrophysics, solar physics, simulations, spectropolarimetry

Participants :
- Max Planck Society (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 171460.8 €
Projet AdaptiveSTED (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Super-resolution methods have recently given new life to fluorescence microscopy; they promise molecular-scale resolution, while maintaining all the benefits of traditional diffraction limited techniques, such as robust labeling methods and three-dimensional imaging capability. However, the current super-resolution techniques only work reliably with thin, brightly labeled, low background samples. STimulated Emission Depletion (STED) super-resolution microscopy in principle is exceptionally well suited for deep imaging, because point-illumination makes it possible to use an optical pinhole that significantly reduces the out-of-focus background signal. However, current STED microscope implementations suffer from very low signal-to-noise ratio (SNR), and the STED depletion beam intensity distribution – that is used to reduce the size of the effective fluorescence volume at the focus – is extremely sensitive to optical aberrations. In AdaptiveSTED project both of these issues will be addressed. The main goal of the AdaptiveSTED project is to develop a real-time aberration correction scheme for STED (and other point-scanning microscopes) that will allow robust, high resolution imaging deep inside complex, aberrating samples. A novel Single Photon Avalanche diode (SPAD) array detector, will make it possible to combine real-time wavefront sensing with high-SNR fluorescence recording into a single detector. The aberration correction scheme will be compatible with any poin-scanning microscopy technique: it will be thoroughly tested with a variety of biological samples in an open-access setting (anyone can use), in STED, two-photon and confocal imaging modes. The aberration correction system will be realized in collaboration with Prof. Martin J. Booth’s group at University of Oxford.

Mots clés : optical microscopy, super resolution, fpga, adaptive optics, realtime systems, sted, wavefront correction, deep imaging

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 180277.2 €
Projet SuperCol (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : SIGNED

SuperCol will train a new generation of scientists in modern super-resolution microscopy and particle functionalisation for improved colloidal design and nanoscale interfacial control for particle-based biosensing. Colloidal-particle-based materials have shown unique abilities in (bio)sensing and other applications because of their large surface-to-volume ratio and biochemical functionalisation. However, we have had only limited success in controlling the sensing properties and cannot yet realise the sensitivity, selectivity and kinetic control that is achieved by e.g. cellular sensing networks. In order to realise this we need to initiate a paradigm shift and create surfaces with a quantified and rationally designed number, distribution, and activity of receptors. To achieve this, we need to understand the structure-function relation between the loading patterns and the sensing characteristics. At this moment, we do not know: (1) how to accurately visualise individual receptors on colloidal surfaces, (2) how to influence the number, distribution and activity of receptors and (3) how this surface organisation translates to highly desired functionalities such as responsiveness and super-selectivity. Super-resolution imaging, advanced particle surface chemistry and advanced modelling will allow to bridge these gaps. However, the field lacks the human capital that can oversee and bridge these disciplines to advance these approaches and effectively (a) control, (b) visualise and quantify, and (c) rationally design surface-functionality to advance particle-based biomedical applications. SuperCol will train the next generation of researchers to overcome this barrier, and will develop e.g. super-selective biosensors for dengue and cholera, and responsive particles that allow biomolecules to be captured (e.g. inflammation markers) and released (e.g. doxorubicin) on demand.

Mots clés : 1  super resolution microscopy, 2  particle based sensors, 3  colloid functionalisation, 4  structure function relationship

Participants :
- Sapienza University of Rome (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 261499.68 €
- Eindhoven University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1062479.52 €
- Blusense diagnostics aps (Danemark) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 297522.0 €
- Max Planck Society (Allemagne) — Partner, beneficiary, Recherche, subvention : 505576.8 €
- Hiq-nano srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 261499.68 €
- KU Leuven (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 512640.0 €
- University of Fribourg (Suisse) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 562553.28 €
- Technical University of Denmark (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 595044.0 €
Projet SuperScienceMe (Horizon 2020, appel à projets 2018)
Action : European Researchers' Night
Statut du projet : CLOSED

SuperScienceMe is a dive into the ocean of knowledge in search of scientific and cultural Calabrian wonders. Visitors will be involved in experiments, games, and artistic performances offered by partners and cooperation bodies. The aim is to create opportunities for matching researchers and citizens, with a special focus on young people. The researcher plays the role of a superhero - SuperScienceMe–that tells the science in a simply way to participants, demonstrating them that it is not separated from real life. Moreover, in line with “European Year of Cultural Heritage” the project aims to promote Calabrian cultural heritage and the superhero will lead visitors in museums and archaeological sites where will be carry out the pre-events. The activities are based on the successful format of the Unical Researchers' Nights previous editions that will be extended to the regional territory, involving Calabrian research/innovation system: • "Experiencing research": demonstrative and fun activities to discover the scientific and cultural work, through a program of more than 100 bookable guided tours in the laboratories, research centres, museums and service facilities, especially dedicated to students; • "Research exhibition": research booths, with spin-off companies and research startups, other innovative companies and social actors. Also present will be the EU, national and regional structural funds, and EEN corners. Other inclusive and social activities will be: • "Experiencing in the hospital", the initiative that brings "Experiencing research" to the Paediatric department of some Calabrian hospitals; • "Research without barriers", a program for integrating the disabled as users and also as authors of scientific demonstrations, cultural initiatives and shows; • "Imagine the research", a video-photography contest; • "Sporting events" involving researchers. The project includes a thematic film review on innovation and performances by artists linked to Calabrian tradition.

Mots clés : science journey, enjoing research, calabrian cultural heritage, innovation promotion, dissemination of scientific culture

Participants :
- University of Reggio Calabria (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 39000.0 €
- Calabria regione (Italie) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- University of Calabria (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 76000.0 €
- Magna Graecia University (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 35000.0 €
- National Research Council (Italie) — Partner, beneficiary, Recherche, subvention : 10000.0 €
Projet CHEMSUPERBOND (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Superconductivity is one of the most exciting discoveries of the last century, with great interest in both, academic and technological environments. These systems can conduct the electric current without energy losses and their commercial development would have an enormous societal impact, allowing large-scale production of important devices such as low-loss power cables, electric motors and high-speed quantum computers. Compressed hydrides bearing lanthanides and transition metals are especially promising materials to reach the goal of room-temperature superconductivity, especially after the recent discovery of superconductivity in LaH10 at 250 K. Other relevant candidates are borides, which share many features with hydrides, as both elements are light metalloids that yield superconductivity at high-pressure and form superconducting compounds with characteristic cluster and ring patterns. Unfortunately, the search is still based on extensive screenings along the periodic table and a framework that allows for the rational proposal of new candidates is missing. In this regard, theoretical chemistry is enormously helpful to make such predictions. However, the calculations in the real (periodic) systems are very expensive as a consequence of the necessity of accounting for electron correlation and electron-phonon coupling, which are computationally demanding. In this context, we will build and study molecular models to bypass the aforementioned calculations and collect the features of superconductors. This way, we will provide easy-to-compute bonding descriptors (e.g. the ELF, QTAIM …) for hydrides and borides. Then, we will benchmark the models with periodic calculations to validate them, and we will propose new candidates for high-T superconductivity. We will also focus on the role of anharmonic effects (crucial for superconductivity in LaH10). All in all, we expect to knock down the limitations in superconductors design by providing fast activity descriptors.

Mots clés : chemical bonding, ab initio methods, superconductivity, vibronic effects, hydrides, borides

Participants :
- Sorbonne Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €
Projet SupramolecularWires (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Supramolecular chemistry offers a platform on which it is possible to engineer modular systems to gain further understanding of complex biological phenomena. The goal of this proposal is to bring supramolecular systems to a more advanced level of complexity by merging synthetic supramolecular structures with engineered proteins and oligonucleotides to generate hybrid supramolecular systems. A program based in five stages is described, where all the systems make use of the inherent dynamic nature of hybrid supramolecular wires to dictate control over protein functions. These architectures are based on disc-shaped molecules that self-assemble to form supramolecular wires, while maintaining the ability to exchange monomers after initial assembly. A covalent approach will be established in stage one, engineered proteins will be covalently attached to the discotic building blocks of the supramolecular wire. Their assembly along the supramolecular wire will induce protein activity, e.g. protease activation. In stage two, short oligonucleotides covalently attached to the discotic building blocks and to the proteins, will provide additional control over the final assembly. The topic of stage three is the recruitment of signalling proteins in a reversible manner by displaying short peptide binding motifs for specific protein binding domains. For stage four, supramolecular wires will exhibit small oligonucleotides that will bind reversibly to protein fusion-oligonucleotide hybrid constructs resulting in protein activation and signal transduction. A higher level of complexity will be explored in stage five, by decorating the supramolecular wires with a larger array of responsive peptide and DNA motifs. This work will contribute new concepts, tools, and materials for elucidation and modulation of biochemical pathways in cells and for bioanalyte detection in vitro, that will be of benefit to the biological community.

Mots clés : self assembly, supramolecular polymers, signaling proteins

Participants :
- Eindhoven University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet ENSUR4LIFE (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Surface anti-condensation and/or anti-biofouling (by surface wettability control) are very interesting and useful properties aimed by industry as they can offer more energy efficient, easy-cleanable or more hygienic products. In the last years, new non-conventional techniques have been developed in order to provide those new functionalities by physical surface modification (avoiding chemical coatings or doping bulk materials). But up to the moment, a technology able to respond to hard industrial requirements as home appliances (i.e. durability, severe boundary conditions, low cost) has not been achieved. This project will research on bringing functional properties to low-cost materials: anti-condensation for stainless steel and one polymer (PP); and anti-biofilm for two polymers (PP and EPDM). Both properties will be ensured by proper surface wettability control. Two non-conventional surface micro/nanostructuration technologies will be researched: PVD nanorods growing for stainless steel, and Thermal-NIL (Th-NIL) for PP and EPDM. This is a multidisciplinary project: combining theory, computer simulation and experimental research. Expected results are very promising as for the first time regarding to bibliography, the nanostructuration by PVD nanorods growing will be achieved on Stainless Steel and Th-NIL micro/nanostructuring will be directly performed on PP and EPDM substrates. Those promising results will impact the industry, not only home appliances sector, but also automotive, aeronautic, surgery, etc. The teamwork composed by BSH –with experience in wettability surface control, nano/micromachining and plastics- and Dr. Bobaru –experienced in PVD, micro/nanocharacterization and metals- will be complemented by DTU (Denmark academic partner) acting as Th-NIL expert and training Dr. Bobaru. Thus the project is also conceived with multisectorial focus.

Mots clés : micro, nanostructuration, pvd nanorod growing, thermal nil, wettability control, anti biofouling, polypropylene  pp, ethylene propylene diene monomer  epdm, stainless steel

Participants :
- BSH Electrodomésticos (Spain) (Espagne) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 158121.6 €