Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet STURM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Floods are major natural disasters with severe impacts in urban areas, where increasingly high population density and infrastructure together with worsening climate change trends exacerbate the risk. Reliable and timely monitoring is critical for resilience in terms of pre-disaster preparedness, emergency response, and post-disaster relief. Remote Sensing accurately evaluates flood extent, but data can be expensive and inaccessible. Open RS represents a not fully exploited potential limited by the relatively coarse resolution. Moreover, recent advances in computer vision techniques based on deep learning (DL) and novel observational opportunities can provide valuable information on both flood extent and depth in combination with RS. STURM aims to advance urban flood knowledge by combining open RS Sentinel imagery and crowdsourcing (semantic and visual data) using DL with the ambition of overcoming the constraints of spatial resolution and limited information. STURM leverages free and newly available opportunistic observing systems providing a globally consistent, open-source-based, smart method for improved multi-source observations of hydroclimatic hazardous events in urban areas. The research objectives are to assess and accurately map urban flood extent and depth with enhanced spatial resolution (sub-pixel mapping and measurements from street-level images) and validate the methodology against real disaster events. STURM’s novel data fusion paradigm suits the demand to fill data and knowledge gaps at the urban scale while offering a benchmark solution for hydrological model validation. The DL-based pipeline combines the strengths of globally available data sources while reducing human and economic resource consumption. Global applicability, low cost, and immediate usability are methodological pillars of the STURM project that determine its high impact potential to enhance urban flood resilience and face the global hydrological challenges of the 2030s and beyond.

Mots clés : urban flood, deep learning, computer vision

Participants :
- Weo sas (Luxembourg) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 184082.0 €
Projet CHROMATOPHORES (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The endosymbiotic integration of cyanobacteria within Eukaryotes was one of the pivotal evolutionary transitions. This transition, however, is difficult to study because modern plastids represent highly derived ‘end-states’ and are not transitionary; we know, therefore, very little about the mechanisms involved. Primary plastid endosymbiosis has occurred only twice: once in the ancestor of Archaeplastida and once independently in the amoeba Paulinella. Each Paulinella cell houses two chromatophores, which are photosynthetic units that resemble plastids yet are more closely related to cyanobacteria. Genetic studies of Paulinella and its cyanobacterial-derived chromatophores revealed it is an intermediary in the evolution of a photosynthetic organelle. Studying Paulinella, therefore, offers unique insight into the mechanistic processes of plastid integration. Despite our growing genetic knowledge, little is known about the integration of the chromatophores in terms of their cellular physiology. In this proposal, I aim to address this by exploring this unique association at the metabolomic, transcriptomic and proteomic levels. First, I plan to characterise the metabolites exchanged between the cell and chromatophores using an isotope-labelling metabolic experiment (objective 1). Second, I will study the coordinated light response of the nucleus and chromatophore at the transcriptional, metabolic, and protein level (objective 2). Finally, I will perform a long-term evolution experiment to expose Paulinella chromatophora to high and fluctuating light regimes to test whether its light regulation can evolve in response to different light environments (objective 3). The outcomes will provide insight into the molecular mechanisms that facilitate the integration of the chromatophores within Paulinella. This in turn will aid our understanding of the acquisition and integration of plastids, and the evolutionary trajectory from endosymbiont to organelle.

Mots clés : organellogenesis, endosymbiosis, experimental evolution, metabolomics, transcriptomics, proteomics

Participants :
- Université Heinrich Heine de Düsseldorf (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet GEM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This project examines the historical transformation of female religious spaces and objects into modern museum contexts. In the 18th and 19th centuries, numerous female monasteries in Europe were abolished during secularization, leading to the reinvention of their spaces as museums and the incorporation of sacred objects into exhibitions. As a result, the cultural memory of these spaces as women's convents faded away. The project's aim is to uncover how the historical dispossession of female ownership of monasteries and sacred objects is evident in contemporary museum displays. Drawing inspiration from "decolonize museums" methodologies, it seeks to propose innovative solutions for addressing gender challenges in modern museum collections.  To achieve this goal, the project employs a case study approach with a primary focus on the Essen Cathedral Treasury in Germany. This marks the first transdisciplinary examination of the Treasury from a gendered perspective. The research delves deeply into how gender binaries have historically influenced the representation of this collection, their persistence in current exhibitions, and subsequently, the development of strategies to transform these representations, which can be applied to similar collections.

Mots clés : secularization, essen cathedral treasury, female monasteries, heritage making, museum formation, cultural appropriation, sacred objects

Participants :
- Université de Groningue (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
- Université Heinrich Heine de Düsseldorf (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PolyRec (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Since the development of the first fully synthetic plastics in the early 20th century, these materials have become ubiquitous in our daily life. The production of plastics has increased considerably, reaching 368 million tons in 2019 and it is expected to double again by 2035. Today’s plastics are designed for performance, cost and durability without taking into consideration their life after use. This has resulted in an annual generation of plastic solid waste of 150 million tonnes. Tackling plastic waste problem is one of the top priorities yet most challenging objectives of the European Union, which has set ambitious policies (i.e. Green Deal) and aims to recycle 50 % of all post-consumer plastics by 2025. The design of plastics with recyclability built into their performance aiming for a circular plastics economy is gaining a lot of attention. With specifically designed monomers, reaction conditions can be used to select the direction of the monomer-polymer equilibrium. Therefore, chemical recycling to monomer presents an attractive alternative since the polymer waste is employed to close the loop in a circular economy process that recovers the economic value of the material.  Through PolyRec, Dr. Ainara Sangroniz proposes to tackle this growing global challenge, by developing high-performance polyurethane (PU) plastics that exhibit a closed-loop circular lifecycle while also having performance properties comparable to those of today’s poorly or non-recyclable commodity plastics. In the outgoing phase, the fellow will develop an innovative class of intrinsically recyclable PUs at the Colorado State University under the supervision of Porf. Eugene Y. X. Chen. In the incoming phase, these will then be depolymerized into their building block monomers and repolymerized back into the PU’s at POLYMAT (University of the Basque Country), supervised by Prof. Haritz Sardon.

Mots clés : green chemistry, recycling

Participants :
- Université du Pays basque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 261380.64 €
- Colorado State University System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet P-use efficient rice (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Phosphorus (P) is one of the most important molecules having a role in almost every aspect of plant metabolism. So, a constant supply of P and its efficient use as Pi are necessary to sustain plant growth, development and yield. However, in most of the agricultural lands, Pi is poorly available to plants. In order to overcome the consequences of Pi deficiency, farmers have adopted excessive and routine application of P fertilizers, causing serious impacts on the environment. There are two main concerns regarding the excessive use of P fertilizers. On one hand, erosion by water and wind results in P runoff into open water bodies, causing a major threat to planetary health. On the other hand, P deposits represent a limited resource on our planet. Additionally, some P forms within the plant (such as phytate) are crucial to determine micronutrient availability for the human nutrition and animal feed. Therefore, there is an urgent need to understand the functional aspects of Pi sensing, transport, signaling and remobilization, and, thus, it is imperative to develop crops with enhanced PUE (P Use Efficiency) and micronutrient availability to support a more sustainable agriculture system. Although rice counts for the third-most produced cereal crop in the world, it is limited to have only 25% PUE, providing an enormous scope for improvement in P nutrition. In this line, we propose to investigate the synthesis and physiological roles of inositol pyrophosphates (PP-InsPs) in Pi signaling and homeostasis to improve the nutritional value of rice. The proposed research will help to better understand how PP-InsPs control PUE, and will provide the knowledge to reduce phytate content in rice seeds, thereby increasing micronutrient bioavailability without compromising plant immunity, health and yield. In short, the discoveries will help to enhance PUE, preserve P-deposits, mitigate the detrimental consequences of excessive P-fertilization and improve the nutritional value of rice.

Mots clés : rice, phosphorus, phosphorus use efficiency, inositol pyrophosphates, phytate, hidden hunger, plant and human nutrition, crop yield, gene editing

Participants :
- Université rhénane Frédéric-Guillaume de Bonn (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet NanoECoAL (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

Friction has a crucial role in almost any technological applications accounting for more than 25% of the world's energy consumption. Ionic liquids (ILs) have been suggested as the next generation of lubricants. Applications of ILs in real-life scenarios rely on full control of their properties in often inaccessible nanogaps. Externally applied electric or magnetic fields have emerged as a strong candidate to change surface polarisation of sliding solids and manipulate ILs lubricating properties in such tight gaps. However, an exhaustive picture of the molecular processes behind electromagnetic control of friction in systems lubricated by ILs is still lacking. NanoECoAL aims at investigating the influence of nanoscale electric and magnetic domains on the organization and shear response of model IL lubricants relevant for any mechanical systems. NanoECoAL will use atomic force microscopy to image, with sub-nanometric resolution, structural organization of ILs molecules as a function of surface electric and magnetic polarization; and at the same time studying their dynamic behaviour, in terms of lubricated friction force. Nanoscale in situ investigations will be complemented by macroscale tribology to bridge the gap between atomistic models and macroscale observations. NanoECoAL’s broader impact will support rational design of new and improved ILs that can reduce energy consumption in advanced tribological applications. Furthermore, the project will imply highly innovative, direct methodological developments that can be broadly applied, thus enhancing European academic and commercial competitiveness. The project has a strong multidisciplinary character and will greatly benefit from the expertise the fellow acquired from his mobility and collaborations with research institutions in different countries. Through NanoECoAL, the fellow will broaden his scientific background, develop complementary knowledge in new areas and increase his chances of success in academia.

Mots clés : friction, lubrication, atomic force microscopy, surface science, tribotronics, magnetism, ferroelectricity

Participants :
- Université de Pise (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €
- Université du Texas (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Edit-hCOs (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Inherited cardiomyopathies are a major cause of sudden cardiac death and are caused by mutations in genes encoding sarcomeric proteins. With an incidence of 3 per 1,000 adults within the European population, inherited cardiomyopathies present a substantial burden to the healthcare services of all European nations. Although a few medications can slow the progression of the disease, today there is no cure for cardiomyopathies. The CRISPR-Cas9 precision genome editing technologies, base and prime editing, can permanently edit point mutations of genes, making them ideal tools to treat cardiomyopathies. To demonstrate the efficacies and therapeutic benefits of these editors in correcting cardiomyopathy-causing mutations, it is necessary to develop robust in vitro models of mature human cardiomyocytes that recapitulate the cellular complexity of the human heart. In the Edit-hCOs project, I will generate and characterize human cardiac organoids (hCOs) harboring clinically relevant cardiomyopathy-causing mutations in the FLNC gene, which encodes for the sarcomeric protein filamin C. hCOs will be generated as three-dimensional scaffold-free cardiac microtissues using tri-cellular combinations of human induced pluripotent stem cell -derived cardiomyocytes, cardiac fibroblasts, and cardiac endothelial cells. Then, I will deploy base and prime editors to fix common FLNC gene mutations in the hCOs, and I will characterize their molecular and functional improvements following correction. In addition, I will generate humanized mouse models harboring the same mutations as patients for future studies on delivery, therapeutic safety, and efficacy of the genome editing components in vivo. Completion of the Edit-hCOs project will allow me to establish a completely innovative and ambitious research line focused on the permanent treatment of cardiomyopathies. This will establish a crucial and important pre-clinical step towards therapeutic genome editing of cardiovascular diseases.

Mots clés : genome editing, cardiac organoids, crispr cas9, filamin c, cardiomyopathy, base editing

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
- Université du Texas (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet HALLOW-PeLEDs (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Lighting sector accounts for nearly ~ 20 % of the global electricity consumption, over 2 % of green-house emission and carbon footprint. With the growing demand of energy consumption, it is urgent to develop alternative technologies, that mitigate global warming. In this regard, light emitting diodes (LEDs) have revolutionized lighting technology, as they are recyclable, energy-efficient and require less power than traditional bulbs. In this regard, LEDs has been lighting our homes, industries ad even medical applications. Particularly, Organic-LEDs (OLEDs) containing organic/polymer molecules such as anthracenes, coumarin derivatives, biphenyl acetylene aryl derivatives etc have been successfully employed in our smartphones and screens. However, their application is limited by cost of manufacture and difficulty in color-tuning with high color-purity, especially over the visible and infra-red regions. Since 2009, a new class of semiconductors known as halide perovskites have emerged as potential candidates for next-generation LEDs owing to their feasibility in terms of processing and manufacturing and excellent opto-electronic properties. However, they possess lead toxicity and are unstable under ambient conditions. In this regard, replacement of lead with other alternatives and use of functional spacer cation has been adopted as a strategy to overcome these challenges. Specifically, designing a functional cation with halogen bond (XB) is rarely studied and can be useful in developing novel halide perovskites with improved structural stability (>1 year, ambient conditions) and improving luminescence properties for PeLEDs. Thus, with the help of MSCA-PF funding program, HALLOW-PeLEDs, attempts to combine the synergy of physical chemistry with supramolecular interactions for optoelectronic applications, by harnessing the virtues of halogen bonds (XB) to form ordered low-dimensional lead-free metal halide perovskites for obtaining efficient Perovskite LEDs (PeLEDs).

Mots clés : halogen bonds, supramolecular interactions, peleds, lead free halide perovskites, fluorinated cations, low dimensional halide perovskites

Participants :
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209483.28 €
- Université de technologie de Chemnitz (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet DecodPhones (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

A core aspect of language comprehension is the extraction of phonetic information from speech. This process is non-trivial due to the transient nature of phonetic segments and their overlapping presence in the acoustic signal. We aim to gain a deeper understanding of this complex process in the context of dyslexia. Individuals with this reading impairment have been found to process two aspects of speech differently from typical readers: they have difficulty extracting individual phonemes from words, and they show signs of imprecise cortical tracking of the speech envelope, an important correlate of speech prosody. However, it is unclear how exactly imprecise tracking of speech leads to phoneme-level deficits. Moreover, despite these deficits, natural speech comprehension in dyslexia remains intact, suggesting that compensation may take place. We address these gaps by applying state-of-the-art phonetic decoding analyses in dyslexia for the first time while varying prosodic and lexical cues within the speech signal. A novel analytical approach will reveal how listeners with and without dyslexia track phonetic segments over time, retain their correct order, and decode them into distinct phonetic representations. Cortical responses to phonetic segments will be tracked in natural speech, in synthesised speech with impoverished prosodic cues, and in meaningless pseudospeech (Jabberwocky) while MEG data are recorded. Comparing the neural dynamics of phonetic decoding in natural speech to speech with impoverished prosodic information will show to what extent prosodic cues facilitate decoding of fine-grained phonetic information. Comparing natural speech to pseudospeech will reveal whether poor phonetic decoding can be compensated with top-down information. The project will provide a better understanding of how phonetic information is extracted from speech and how this may relate to the persistent deficits in dyslexia, with important implications for theory and remediation.

Mots clés : speech processing, phonetic decoding, dyslexia, phonology, prosody, meg

Participants :
- Basque Center on Cognition, Brain and Language (Espagne) — Coordinator, beneficiary, Recherche, subvention : 209914.56 €
- Université Stanford (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet READHY (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The activation and functionalization of dinitrogen under mild conditions remains one of the major challenges of contemporary chemistry. Despite being the most abundant form of nitrogen, the strength of its triple bond renders it highly unreactive. Thus very few and not yet efficient systems mediate its functionalization.  This proposal entitled READHY (REActivity of Dinitrogen and HYdrocarbons for C-N bond formation) aims to achieve the catalytic formation of C-N bonds from dinitrogen and inactivated hydrocarbons by iron catalysts stabilized by novel bifunctional diketiminate ligands. The project is very ambitious both synthetically and conceptually, but it builds on solid preliminary work and the expertise of the host groups.  This original MSCA project will offer cutting-edge science on the road to fulfil the long-standing goal of efficient dinitrogen functionalization for the synthesis of N-containing organic molecules, with long-term technological, economic and societal benefits.  READHY will be developed by the candidate at Yale University (United Stated, outgoing phase) and the University of Seville (Spain, incoming phase) under the supervision of Prof. P. L. Holland and Dr J. Campos, respectively. The project combines ligand design, advanced organometallic studies, and important applications in dinitrogen chemistry. Moreover, the dynamism of the host groups and the training plan offer ideal conditions for the researcher to enhance its potential towards the start of her independent career.

Mots clés : n2 reduction n2 funtionalization transition metal bimetallic systems

Participants :
- Université Yale (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Séville (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 261380.64 €
- Université de Caroline du Nord à Chapel Hill (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €