Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet OakMycEvo (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

This proposal aims to construct an evolutionary framework for the molecular interactions between ectomycorrhizal fungi and their plant hosts. Ectomycorrhizal (ECM) symbiosis is a mutualistic association between fungi and trees that is founded on reciprocal exchange of nutrients, facilitating growth in nutrient-limited or otherwise stressful environments. The symbiosis has evolved independently in many fungal clades, raising questions about its evolvability and the ecological redundancy of different ECM fungi. The ability of one ECM fungus to functionally replace another is especially salient in light of environmental change and loss of biodiversity. What components of communication between fungus and plant are conserved among ECM species? How conserved are molecular interactions at different phylogenetic scales? What are the molecular mechanisms responsible for phenotypic variation? ECM fungi from the genus Amanita will be grown together with the host Quercus robur (pendunculate oak). Q. robur displays endogenous rhythmic growth with alternating root and shoot flushes, distinct physiological states of growth that influence interactions with ECM fungi. The fungal strains are selected to survey variation i) between different Amanita ECM species and ii) in comparison with closely related saprobic Amanita sp., using a phylogenomic approach. We will profile genes expressed on both fungal and plant side at different time points: during mycorrhizal development and in mature mycorrhizas, while separating each time point into periods of root flush and shoot flush. We will profile a compendium of traits related to the functioning and success of ECM symbiosis at each developmental stage. Together these results will allow us to develop a detailed mechanistic view of the genes and pathways underlying ECM symbiosis, their evolutionary dynamics across a phylogenetic gradient of fungal partners and their impact on the different physiological stages of plant growth.

Mots clés : ectomycorrhizal symbiosis, genome evolution, regulatory networks, convergent evolution, evolutionary transitions, coevolution, plant fungal interactions

Participants :
- Helmholtz Centre for Environmental Research (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 174806.4 €
Projet B-SMART (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This proposal aims to develop new intelligent cementitious nanocomposites for multifunctional built infrastructure made by combining ordinary Portland cement (OPC) with cheap bio-nanomaterials synthesised from root vegetable waste such as carrot and beetroot waste streams produced by the food processing industry. These innovative cementitious composites are not only superior to current cement products in terms of mechanical and microstructure properties, but also use smaller dosages of cement thereby significantly reducing both the energy consumption and CO2 emissions associated with the cement manufacturing. Further, as a result of these bio nanomaterials, the resulting cementitious composites exhibit an astonishing piezoelectric effect enabling concrete structures to perform multiple functions such as: 1) self-monitoring mechanism to sense, feel and diagnose impending catastrophic structural failures and 2) green energy production by converting mechanical energy (i.e. vibration and impact induced by transport systems, wind and water waves) into inexpensive and readily available electrical energy source. Capturing this waste energy source from the built infrastructure surfaces is of great importance as it can be used to power the built-in-self-monitoring systems, houses and conventional auxiliary systems such as lighting posts, traffic lights, advertising boards and electric vehicle charging stations.

Mots clés : bionanomaterials, smart cementitious, energy harvesting, self sensing

Participants :
- Lancaster University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet cAAC-Light (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This proposal aims to explore the feasibility and scope of thermal and light-driven bond activation and catalysis by sub-valent group 14 Main Group (MG) systems stabilized by highly σ-donating cAAC (cyclic (alkyl)amino carbene) ligands, exploiting their reduced HOMO-LUMO energy gaps, including MG-cAAC complexes, directly bonded MG/TM ( TM = transition metal) species and unprecedented hybrid MG/TM systems. We will initially target exotic cationic MG-cAAC complexes to investigate their capacity towards the activation of common E—H bonds (e.g. silanes, boranes or amines,including ammonia), including reversibility studies. This will be followed by exploring the activation of more challenging substrates, particularly the oxidative cleavage of C—H bonds. To enhance the capacity of activating less reactive bonds (e.g. intermolecular C—H, C—X…), as well as to enable more accessible reversibility routes (e.g. reversible H2 activation), we will target a variety of cooperative systems that will rely on the synergistic action of a MG element and a TM in close proximity. Investigating these synergistic effects will set the basis for designing more efficient systems in the search for innovative cooperative catalysis. In particular, this approach will permit the low-valent MG element to act as the activator, while the TM in close proximity may provide additional mechanistic routes for further functionalization. In the long term, we expect that our novel strategy will provide solid grounds for further developments in the vivid areas of low-valent MG chemistry and in particular in their use as catalysts for challenging transformations.

Mots clés : main group, cooperative catalysis, germanium

Participants :
- Universidad de Sevilla (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 163099.2 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet FUSEDESIGN (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This proposal aims to stabilize the pre-fusion form of rabies virus glycoprotein (RVG), the most structurally-tractable clinically-relevant class III fusogen by combining computational biology, immunology, and structural biology. Rabies virus is fatal; it kills 55,000 people each year and costs billions to control it in animals. Current human rabies vaccines are cumbersome to use and prohibitively costly, thus there is demand for a new generation of rabies vaccines. Enveloped viruses’ fusion glycoproteins are important subunit vaccine candidates. Structure-guided stabilization of class I fusogens has been a major advance in vaccinology. Many major human pathogens have class III fusogens (notably, all herpesviruses and rabies virus): several post-fusion structures have been reported, but their antigenically critical pre-fusion forms have not been stabilized. A high-quality homology model of RVG will guide design of mutations to stabilise the trimeric pre-fusion protein. Designed mutants will be transiently expressed in mammalian cells, selected for stability, and characterized immunologically. Lead candidates will be used as immunogens in mouse models and in structural studies. These data will guide design of improved rabies vaccines, and provide insights into RVG’s interaction with neutralizing antibodies and host receptors. Certain structural elements are conserved across class III fusogens, and so the approach may lead towards stabilization of herpesvirus fusogens. The fellowship will be based between two departments at a world-class host institution. Together, they will offer the Researcher an unusual combination of exposure to both cutting-edge molecular biochemistry and Europe’s leading academic centre for translational vaccine development. This unique training will equip the Researcher with a truly discipline-spanning skill set and position her to make a leading contribution to the development of novel antiviral interventions and public health.

Mots clés : structural vaccinology, membrane fusion protein, rabies virus, in silico protein stabilization, protein structure, conformational state

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet NPL (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : TERMINATED

This proposal deals with the application of Dr. Francisco Cardona for a fellowship to work on the design and synthesis of new macrocyclic natural product like compounds (NPLs) which have potential in chemical biology or drug discovery at NUI Galway. A training programme has been designed for Dr. Cardona to enable him to broaden and deepen his professional knowledge and develop complementary skills that will mature him as a researcher. The project involves the innovative synthesis of new NPLs based on novel macrocycles. The main objective from the scientific point of view is to prepare new scaffolds that have not been explored to date and to generate compounds for screening in a wide variety of bioassays. This will determine if the scaffolds are relevant for developing therapies to cancer or infection, for example. There is a need for this research in that industry and academia have focused for a long time on a limited number of scaffolds and drugs have been based on a limited number of frameworks. In this research the applicant aims to increase the number of frameworks available and to also develop routes that are concise. Compounds will be evaluated for their biological properties within the project and managed for shipping to collaborating researchers for screening. Dr. Cardona will broaden and deepen his professional expertise, gain knowledge of screening and interpretation of biological results and of approaches in medicinal chemistry. This professional knowledge will increase the researchers capacity to contribute to related projects in industry or academic or research organisations later in is career. They will undertake a programme of complementary skills training to enhance relevance to future employers. The host is committed to ensuring that the relationship with the researcher will be conducive to successful performance in generating, transferring, sharing and disseminating knowledge and technological development.

Mots clés : macrocycles

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet Prison Self-harm (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This proposal deals with the persistent problem of self-harm in prisons and addresses limitations of mainstream approaches by outlining a theoretical approach informed by Queer Studies. This project aims to offer a queer interpretation of these phenomena through a more holistic, less pathologizing frame of understanding self-harming experiences in prison settings. My research so far (Vasiliou, 2020) has examined the paradox of pleasure in ex-prisoners’ accounts of pain and suffering in prison and has attempted to engage issues of gender and sexuality in considering narratives of pain/pleasure, agency and resistance. These findings are the base for this training and research proposal which will focus specifically on understanding the problem of self-harm in prisons from a Queer Criminology (QC) perspective. The project is divided in three phases: First, during the outgoing phase, I will train for 5 months with a prominent expert in the emerging field of Queer Criminology in Australia (Dr Matthew Ball) and, second I will work with Dr Eric Stanley in the Department of Gender and Women’s Studies of the University of California (19 months). In the return phase, I will work for 12 months in the department of Sociology in the University of Warwick with an outstanding expert on the issue of women’s self-harming in prison settings (Dr Anastasia Chamberlen). The aims of the project are: 1) training in QC Theory and Methodology 2) To outline the scene in relation to self-harming issues in European prison settings. 3) To design and apply a QS methodological tool for conducting research with self-harming individuals in ex-prisoners population. 4) To conduct research with ex-prisoners about experiences of self-harming at the return phase in the UK. 5) To publish a brief policy document in which issues of self harming will be addressed from a holistic perspective with a particular interest about issues of gender and sexuality. This project will make an important empirical and theoretical contribution to the issues of self-harming in prison settings and will contribute to the development of the field of QC in Europe.

Mots clés : self harm, prisons, queer studies, criminology

Participants :
- Queensland University of Technology (Australie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Warwick (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 273026.0 €
Projet ExtSpGraphLim (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

This proposal focuses on two related families of problems concerning algebraic invariants of graphs, i.e., networks. On the one hand, we study extremal values of algebraic invariants, i. e., we propose to give lower and upper bounds for certain algebraic graph parameters in a given class of graphs like d{regular graphs. On the other hand, we study the behavior of algebraic invariants of very large graphs, more precisely we study whether for a certain graph parameter p(G) it is true that the sequence (p(G_n)) converges if the graph sequence (G_n) converges in some sense. The two families of problems are connected by the observation that many graph parameter does not achieve its extremal value on finite graphs, but on some infinite object which is the limit of finite graphs.

Mots clés : extremal graphs, regular graphs, graph limits

Participants :
- Eötvös Loránd University (Hongrie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 134239.2 €
Projet DNA-BIO (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

This proposal is a 24-month Marie Curie Global Fellowship scheme which involves a British experienced researcher to undertake a training-through-research project on the development of cutting-edge diamond based nanomaterials for biosensing applications (DNA-BIO) in liaison with National Institutes for Materials Science (NIMS), Japan. Dr. Haitao Ye has been conducting original research into diamond growth and characterisation and device fabrication at University of Leicester (UoL), and has established an excellent track record. NIMS is a world-leading research institution in the field with an international reputation of technological innovation, enterprise participation, and knowledge transfer. The proposal will tackle the challenging development of multifunctional nanodiamond species and assess their applications to bioimaging and sensing. Success will deliver new approaches for both surface functionalisation and doping of nanodiamonds and bring high-resolution bioimaging sensors to the research community. It will contribute to the EU’s economy by developing next-generation biomedical sensor and significantly widening the competences of the fellow to reach his professional maturity with interdisciplinary expertise and complementary skills unique to the ERA. The fellow is leading the development of UoL’s teaching and research activities in surface engineering and biomaterials and the highest quality training under supervision of internationally leading scientists is indispensable for his career development which will in turn benefit the UK and the EU.

Mots clés : materials process, surface functionalisation, sensor

Participants :
- National Institute for Materials Science (Japon) — Partner, organization partner, Recherche, subvention : 0.0 €
- University of Leicester (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 204847.68 €
Projet CEDMMC (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This proposal is an opportunity for a promising academic at the beginning of her career with expertise in user interfaces and user experience to work and train with two internationally recognised centres with expertise in geometric modelling and mass customisation. This collaboration will significantly boost her career progress and will allow her to develop into a mature and professional European Researcher as a leading figure in the subject of mass customisation user experience. It will also establish a long lasting connection between the two Hosts and the Hosts and the Applicant. In mass customisation (MC) creating a satisfying and engaging experience for the consumer is significant, which has been considered as one of the success factors for MC, especially in terms of increasing consumer loyalty. Nevertheless, a number of effort has been made mainly focusing on the technical and business implementation of MC, very little research considers the consumer interaction and consumer experience in MC environment, even though some of them focused on the menu choice design rather than creating an overall experience of interaction, and some of them investigate consumer experience from the manufacture’s perspective rather than the consumer’s perspective. Given these considerations, this research is designed to identify a framework in terms of positive and negative influences of online MC design on consumer experience; identify strategies for initial functional model for MC design based on previous framework; validate the strategies to further develop the model, and use the model to inform the best practice guidelines to provide the design reference and standards for MC.

Mots clés : mass customisation, consumer experience, consumer manufacturer interaction, online configurator, 3d printing

Participants :
- Bournemouth University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet NonnegativeRank (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This proposal is centered on nonnegative rank - a notion that modifies the definition of matrix rank. This project is basic research aimed to better understand the geometry of matrices and tensors of nonnegative rank at most r, how this knowledge can be employed to improve exact and numerical nonnegative matrix algorithms, obtain an algorithm for nested polytopes in dimension three, and address questions about mixture models in statistics. Computing and understanding nonnegative rank is truly interdisciplinary. Completing this project requires techniques from polyhedral geometry, real algebraic geometry, optimization, statistics, symbolic algebra, and numerics.

Mots clés : nonnegative rank, applied algebraic geometry, algebraic statistics, real algebraic geometry, algebraic boundary, polytopes, zero patterns, maximum likelihood estimation, em algorithm

Participants :
- Massachusetts Institute of Technology (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Sorbonne Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166603.2 €
Projet DEGENHA (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This proposal outlines the development of a suite of truly general hydroacylation catalysts that demonstrate high levels of functional group tolerance, enantioselectivity, broad applicability and ease of use in the laboratory. These advances will be achieved by the development of a new modular ligand system, based on the small-bite angle hemilabile diphosphines. By achieving these advances hydroacylation will become a general and robust disconnection for the synthesis of fine and bulk chemicals, new materials and target molecules.

Mots clés : hydroacylation, enantioselective, alkene, chiral phosphine

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet MOCCA (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This proposal proposal intends to systematically pioneer the cross-cultural mobile user experience issues and provide valuable guidelines for designing cultural adaptability into the context-awareness of smart phones. The objectives of this proposal are to: 1) Identify the user experience problems that exists in mobile context-awareness system in Europe and China, and uncover the key factors producing the problems; 2) Examine the influence of context-awareness factors and culture difference on mobile context-aware cross-cultural applications (MOCCA); 3) Apply the findings to improving the design of mobile context-awareness systems and demonstrate specific user experiences for European and Chinese users of smart phones with cultural adaptability. In WP 1, 2 and 3, we will use a combination of qualitative methods (contextual inquiry) and quantitative methods (experiment and psychophysiological measures) to support our objective of identifying and measuring cross-cultural user experiences of the smart phone and the applications. In WP 4 we will apply a user-centered design method to ensure that our cross-cultural UX measures and design guidelines for context-awareness features in smart phones are in fact usable. The experienced researcher will improve and explore alternative approaches to measuring user experience, under supervision provided by the host university, and in close collaboration with the university providing the secondment, Chinese universities, and a European (Danish) high tech company. The research will be published in leading journals in the field of Human-Computer Interaction and disseminated in Europe and China. The host university provides intellectual and physical infrastructure specifically aimed to bring the experienced researcher to the next level of a professor position in the field of business-oriented Human-Computer Interaction, with a focus on extending and bridging user experience research between Europe and China.

Mots clés : mobile context awareness, cultural usability, culture, usability, user experience

Participants :
- Copenhagen Business School (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €