Projet Adaptmet (Horizon Europe, appel à projets 2023)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Adaptmet aims to develop an advanced training program encompassing the multifaceted aspects of metastasis adaptation mechanisms, intending to equip budding researchers with the necessary skills to emerge as leaders in this field. A robust mentoring and training strategy, coupled with cutting-edge methodologies and a diverse range of complementary soft skills, are crucial to this endeavour. These skills are imparted through local and network-wide events, fostering seamless research progression, and nurturing successful career trajectories. Scientifically, Adaptmet addresses an unmet medical need by harnessing basic science to revolutionize drug development and, ultimately, enhance patient care. Specifically, scientific work packages (WPs) have been designed to approach metastasis from various functional perspectives. In order to metastasize, cancer cells must adeptly coordinate diverse cellular functions (Cell Fate - WP1). Additionally, understanding the intricate interactions between metastatic cells, the host immune system, and tissue stroma is pivotal (Environment – WP2). Crucial aspects such as the kinetics of metastasis and the mechanisms governing latency, particularly, remain inadequately understood (Latency – WP3). Clarifying this complexity, unravelling mechanisms underlying therapy failure, and identifying expansion pathways are central to defining novel therapeutic targets (Expansion – WP4). In essence, Adaptmet stands at the intersection of a rapidly evolving multidisciplinary domain, amalgamating distinct fields that often face challenges in mutual communication. The success of Adaptmet hinges upon robust partnerships, open exchange of ideas, state-of-the-art methodologies and equipment, and the exploitation of synergistic opportunities among network members. This collaboration spans diverse perspectives, bridging gaps between different disciplines, thereby breaking down barriers and fostering interdisciplinary cohesion.

Mots clés : metastasis, cancer, latency, stroma, dormancy

Participants :
- Fundació Clínic per a la Recerca Biomèdica (Espagne) — Partner, beneficiary, Recherche, subvention : 251971.2 €
- Gr espanol de estudio y tratamientode intensific. y otras estrateg.experiment. en tumores solidos - grupo solti (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Institute of Cancer Research (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Boehringer Ingelheim (Austria) (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 270331.2 €
- Cancer state therapeutics (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 262620.0 €
- Université de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Saso kocevar (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Antoni van Leeuwenhoekziekenhuis (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 274370.4 €
- Research Institute of Molecular Pathology (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 270331.2 €
- Institut de recherche en biomédecine (Espagne) — Coordinator, beneficiary, Recherche, subvention : 503942.4 €
- Zs associates as (Danemark) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 301788.0 €
- Fundación Josep Carreras Contra la Leucemia (Espagne) — Partner, beneficiary, Recherche, subvention : 251971.2 €
- Université technique du Danemark (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Bâle (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Vienne (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université libre de Bruxelles (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262620.0 €
- Scienseed sl (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- CERCA Institution (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Leiden University Medical Center (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Lund (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 293709.6 €
- Université d'Helsinki (Finlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 572976.0 €
- Université de Barcelone (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €