Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Symbiosis (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Virtually all plants interact with endosymbiotic microorganisms that inhabit various plant organs. The biotechnological applications of endosymbiotic bacteria can be numerous (e.g. sustainable agriculture through biocontrol and biofertilization). Accordingly, current research efforts have focused on the molecular mechanisms involved in microbial endosymbiosis. Although these interactions can be beneficial, neutral or detrimental to the host and may play a larger role on host fitness and survival, the long-term effects of endosymbiosis on diversification patterns are still unknown. In this project, the ecological conditions for the establishment of leaf endosymbiosis and the long-term effect on the host plant speciation will be studied for the first time through a unique combination of plant diversity, endophytes, ecology and time. The key scientific objectives are (1) to identify the significant environmental factors influencing the presence of bacterial leaf symbionts and (2) to test if bacterial leaf symbiosis acts as a driver for speciation. This will enable us to answer under which circumstances endosymbiotic plant-bacteria interactions are established in nature, what is the stimulus of these interactions, and what are the consequences for the evolutionary history of both endosymbiont and host. This knowledge will provide a better understanding of the impact of long-term endosymbiosis on plant diversification processes. A central aspect of this proposal is the synergy between the applicant and the beneficiary. The pioneering PhD work of the applicant in the field of bacterial leaf symbiosis will now be taken to a new and predictive level by adding an evolutionary perspective with the help of the expertise of leading scientists studying the impact of biological interactions on biodiversity, state-of-the-art facilities including next generation sequencing and a vibrant and internationally renowned research community at the Natural History Museum of Denmark.


Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet ENZYME-SWITCHES (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

WHY: Diagnostic markers detection plays a crucial role in the diagnosis of human disorders. Unfortunately, however, current methods routinely used for the detection of these biomarkers still require sophisticated equipment, washing intensive, reagent-intensive multi-step processes. In attempt to overcome the cited limitations, the development of platforms supporting the sensitive, specific, rapid and easy to use measurement for several diagnostic biomarkers, directly in real samples, is urgently needed. WHAT: ENZYME-SWITCHES is a multidisciplinary and interdisciplinary programme with the principal aim to develop a new generation of enzyme-based biosensors that could prove transformative for diagnostic applications. To achieve this goal, I will join the high specificity and sensitivity of enzymes, and the high programmability and versatility of synthetic responsive DNA nanodevices to develop DNA-conjugated enzymes able to provide sensitive detection of a wide range of diagnostic markers. HOW: This challenging objective will be reached thanks to the multidisciplinary and complementary approach of the outgoing and incoming research groups. I will join the expertise of Prof. Plaxco (outgoing supervisor) in molecular biology, enzymes, biosensor technology, bioengineering device and biophysic with that of Prof. Ricci (incoming supervisor) in the DNA-Nanotechnology field, analytical chemistry and electrochemistry to optimize the proposed new biosensors platform. I have already a promising research profile demonstrated by a strong publication track-record, by several awards received and by fruitful international mobility. Thanks to this MSC Fellowship, I will further strengthen my CV and diversify my scientific knowledge acquiring cutting-edge competences as well as complementary skills, which will boost my scientific independence and my future career.

Mots clés : dna nanotechnology, enzymatic biosensors, biosensors, dna sensors, aptamers, electrochemical, sensors, point of care sensors

Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Rome Tor Vergata (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 168369.6 €
Projet DNA-bots (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

WHY: Enzyme-powered nanorobotic devices are able to self-propel thanks to the conversion of a substrate into products, holding a great potential for biomedical applications. A step forward in the field would be the precise control and design over the structure and enzyme spatial configuration, as well as the integration of complex functions. WHAT: DNA-bots is an interdisciplinary approach in which enzyme-propulsion and DNA nanotechnology will be merged to develop a new class of biocompatible and biodegradable nanorobotic devices able to self-propel, sense and actuate in front of specific stimuli. To achieve this goal, I will undertake a high risk/high gain research approach at the forefront of nanotechnology. The leading idea is to design and fabricate DNA nanostructures which will be site-specifically functionalized with enzymes to generate self-propulsion. The enzyme-powered DNA nanorobots will be further engineered by integrating DNA nanoswitches able to sense and perform loading and release of cargoes upon specific stimuli. HOW: The challenge met by this Project is to provide a groundbreaking contribution to DNA nanotechnology and nanorobotics. To achieve these objectives, I will be trained at the Host group led by Prof. Francesco Ricci (University of Rome Tor Vergata, Italy), which is a young and dynamic team at the vanguard of the use of DNA nanotechnology for sensing and drug-delivery applications. The Fellowship will proceed through a well-defined set of research and training tasks, organized into four work packages. Thanks to this MSCA Fellowship, I will continue expanding my scientific knowledge and acquiring cutting-edge skills (in synthetic biology, DNA nanotechnology, and nanorobotics), which will significantly impact my career as a researcher and help me to strenghten my position as an independent and mature researcher.

Mots clés : dna nanotechnology, enzyme powered nanorobots, synthetic biology

Participants :
- University of Rome Tor Vergata (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183473.28 €
Projet RE-IMMUNE (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

WHY: To effectively bring siRNA-based therapeutic for cancer immunotherapy into the hands of clinicians requires the development of fundamentally new mechanisms to overcome current drawbacks. Accomplishing this will enable more efficient treatment with less side effects. WHAT: RE-IMMUNE is an interdisciplinary programme in which the field of nanomaterial and nucleic acid nanotechnology merge to develop intelligent nano- encapsulated siRNA for safe and efficient delivery of siRNA in cancer-associated immune cells, to re-program and shift the tumor microenvironment from pro to anti-tumoral. To achieve this goal, I will undertake a high risk/high gain programme at the forefront of nanomedicine. The leading idea is to overcome the drawbacks of naked siRNA by combining two synergic strategies that will protect siRNA until recognition of its target site. I will evaluate intracellular trafficking of siRNA nanodevices and the silencing effect. I will also investigate possible synergic effect of a siRNA cocktail able to target different genes at the same time. Finally, I will evaluate the re-immunoediting action in vivo. HOW: The challenge met by the proposed program is to provide a groundbreaking contribution to cancer treatment. To achieve these objectives, I will combine the different scientific backgrounds and expertise of two leading scientists. Prof. Frank Caruso (University of Melbourne) is a world-wide recognized expert on nanomaterials and biomedicine, and Prof. Francesco Ricci (University of Rome Tor Vergata) leads a young and dynamic group at the forefront of DNA nanotechnology for sensing and drug-delivery applications. The fellowship will proceed through a well-defined set of research and training tasks. Thanks to this MSC Fellowship, I will diversify my scientific knowledge and acquire cutting-edge competences (in nanomaterials, microscopy, and nanoscopy), as well as complementary skills, which will become the foundation of my scientific independence.

Mots clés : dna nanotechnology, layer by layer technology, nanomedicine, smart materials, sirna, cancer, immunotherapy, super resolution microscopy

Participants :
- University of Melbourne (Australie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Rome Tor Vergata (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 250518.6 €
Projet WaMStrIn (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

WaMStrIn will re-evaluate the relationship between human settlement and the changing hydrological network of the Indus area of Pakistan during the emergence of first urban centres in ancient South Asia (2500-1900 BC). The ancient Indus was the most extensive of the three so-called cradles of Old World civilisation and a number of attempts have been made to trace the network of palaeorivers that watered this region and sustained its ancient population. Using a novel combination of multi-temporal satellite remote sensing, GIS-based topographic analysis, geostatistics and network analysis WaMStrIn will overcome previous problems in the detection of ancient rivers and associated archaeological sites. In doing so WaMStrIn will provide new hypotheses and quantifiable open access data on (1) past water management, (2) the mechanism employed to cope with changing water availability and (3) the consequences of a long-term shift towards more arid conditions for South Asia's earliest large-scale, urban, and interconnected society. Water management and availability are relevant to a range of current archaeological debates, particularly those related to food security, sustainability and resilience. These issues are also directly relevant to current investigation into the impact of climate change on modern populations in regions that are becoming increasingly arid. WaMStrIn study area is core to this debate as it was intensely occupied by an urban society that was affected by a dramatic weakening of the Indian Summer Monsoon around 4200 years ago. The successful development of WaMStrIn will provide relevant new methods for the study of water management in the past and important new data for a sustainable planning and management of water in the current context of climate change towards more arid conditions.

Mots clés : ancient indus, water management, climate change, remote sensing

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet Wanderlust (Horizon 2020, appel à projets 2018)
Action : European Researchers' Night
Statut du projet : CLOSED

Wanderlust is the Zaragoza European Researchers Night 8th edition design to aproach researchers to general public. We chose Wanderlust because it means travel, it menas the desire to know more, to reach new places, to be inspired from different cultures. We think it is a metaphore, and it represents the spirit of the researchers life, and it easy connect with people. It also a good approach to the european dimension of the research, and it is easy researchers identificate themself with the project. The event will be a "fiesta" of outreach in Zaragoza. The last year we have increase awareness of public, we increase visitors, researchers involve and we managed to create a group of stakeholdes who support the project. The key of the susccess of our event is the know how of ESCIENCIA who manage the project in Aragon from 2011, becouse it is a SME speciallize in science communication. We support researchers to deseign their activities, we train them how to speak to public, and we work both with enthusiastic public and science reluctant public in our project. The wanderlust is a perfect claim to address public at large. It is an easy way to citizens to become part of the event. The feeling of explore is a common point for most public. We are working with Educational deparments of Spannish, Aragon and Zaragoza governments. We have already signed letter of endorsement of Aragon and Zaragoza. The project has a Science Fair as a point ot reach pupils. It is an effective way to rise awareness prior to the event, to involve schools and communicate "science is fun" to young people. In the three last edition we have pool the participants and the remark the Science Fair as "Fun and Challenged". The European Researchers Night in Zaragoza will take place in the Center of the city, in the whereabouts of CaxiaForum one of the most emblematic and futuristics buildings of Zaragoza. We will make aware of the night 375.000 people and 16000 will take part in activities.

Mots clés : outreach, general public, caixaforum zaragoza, education, science fair, hands on, geocaching game, teatre, edutainment, mscfellows, show, humorous mologues, music

Participants :
- Esciencia eventos cientificos sl (Espagne) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 120000.0 €
Projet Wanderlust (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

Wanderlust is the name of the European Researchers Night in Zaragoza. This year 2020 it will celebrate the 11th edition. Wanderlust is a concept that includes the core values of research: the excitement of discovering, exploring, researching and the emotion of sharing this stimulating work with society. Wanderlust is the largest scientific festival in Spain and consists of a true festival of culture that combines different kinds of activities and performances to get all audiences, from 3 to 99 years old. Both the event and the program of activities are designed to value and disseminate the figure and valuable work of our researchers. In order to get this goal, we carry out synergies and innovative experiences that combine research with other cultural disciplines. The success of the project is based on the experience of the organizing team. Esciencia is a company specialized in science outreach with more than 13 years of experience and with a multidisciplinary team of 30 employees. We have been the organizers in the past 10 editions. We have the “know-how” to make this event a success of participants and impact scope, as well as satisfaction of the visitors. We use a proved methodology whose strengths are: the event's communication campaign, communication advice and training in didactic and communication tools to researchers to set up their performances, and the evaluation procces that allows us to enforce the suggestions of the public and to improve the event. As a result of this experience we have a network of stakeholders, sponsors, researchers and suppliers that guarantee the achievement of th objectives. Our event has become a national reference. We have created a powerful network of contacts and collaborate with several projects. In this edition we improve our rates of participation and impact and we will reach 375,000 people with the promotional campaign and 10,000 direct participants in the event.

Mots clés : outreach, general public, caixaforum zaragoza, education, science fair, hands on, geocaching, game, teatre, edutainment, mscfellows, show, humorous mologues, music

Participants :
- Esciencia eventos cientificos sl (Espagne) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 60000.0 €
Projet TreatRec (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks - Industrial Doctorates
Panel : Environment and Geosciences
Statut du projet : CLOSED

Wastewater treatment and management in Europe has a large potential for growth; however needs to be supported by education of a new generation of interdisciplinarily trained wastewater professionals able to face future challenges and implement wastewater-related directives in practice. TreatRec, with the participationof two academic partners (ICRA-Catalan Institute for Water Research and University of Girona) and two non-academic (ATKINS and AQUAFIN) identifies several pertinent technological gaps and knowledge needs around which we have built a research programme. TreatRec involves equally academia and industry with a clear aim of producing a group of young researchers capable of conducting high quality research, but also able to address industrial and societal needs and implement wastewater-related directives in practice. The five researchers will conduct their scientific projects in an environment that combines industrial excellence in the development, design, construction and management of wastewater treatment systems, with complementary academic excellence in a) hypothesis-driven research involving the improvement/upgrading of state-of-the art technologies and the deepening the understanding of fate and removal of emerging contaminants in wastewater treatment systems and in b) applied research involving the development of decision support systems which allow for the encapsulation of knowledge for further use in decision-making processes. As a general goal, academic and non-academic partners of TreatRec, including WWTP operators, engineers responsible for the design and a water authority which has experience in water policy implementation, a set of recommendations will be generated to provide guidance for decision-makers on upgrading wastewater treatment plants for future challenges such as microcontaminants removal and nutrient recovery from a sustainable perspective.

Mots clés : wastewater treatment, upgrading, microcontaminants removal, resource recovery, global change, stress conditions, decision support system

Participants :
- Aquaplus (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 250560.0 €
- Atkins limited (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 273287.88 €
- Bavarian Research Alliance (Allemagne) — Partner, organization partner, Autres, subvention : 0.0 €
- Waterschap de dommel (Pays-Bas) — Partner, organization partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- University of Bath (Royaume-Uni) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Girona (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 247872.96 €
- CERCA Institution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 495745.92 €
- Severn Trent (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet ORGANO-GOLD CAT (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. The proposed research aims to develop conceptually innovative catalytic methods to rapidly generate, in one single step, architecturally complex chiral natural-like compounds. Natural products have been selected in evolution and their underlying structural scaffolds define biologically relevant fractions of chemical space. Consequently, compound libraries inspired by natural structures deliver lead candidates with a higher hit-rate than conventional lead generation strategies. We will pursue the proposed research project under the guiding principle that compound development should be driven by discoveries and innovation in chemical methodology. The goal of the research project is to combine the potential of asymmetric organocatalysis and gold catalysis, powerful fields of molecule activation, to find cost-effective synthetic methods for reproducing the rich structural diversity of natural molecules. Since the vast majority of natural products and drug-like compounds possess heterocyclic moieties, we will focus on preparing diverse heterocyclic compounds, especially based on the furan unit. The resulting synthetic platform will be used as an ideal starting point for assembling enantiopure chiral 2,3-furan fused carbocycles, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place him in an excellent position for the next career move

Mots clés : cascade reactions, gold catalysis, organocatalysis, enantioselective catalysis, drug discovery

Participants :
- Institut Català d'Investigació Química (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €
Projet CARDIALLY (Horizon 2020, appel à projets 2015)
Action : Staff Exchanges
Panel : Physics
Statut du projet : CLOSED

We are proposing a four-year programme of knowledge transfer between Aston University (ASTON, UK), Universita Degli Studi Di Brescia (UNIBS, Italy), Diasens (Diasens, Serbia), and Novosibirsk State University (NSU, Russia). The aim of our interdisciplinary proposal is to bring together the unique expertise of participants to solve the important and challenging problem of heart failure prediction and diagnostic. Our transformative approach combines advanced methods of complex data analysis and novel diagnostic technologies to prevent highly damaging consequences of this deadly and disabling disease. Strong interdisciplinary nature of the project and a balance of industrial applications and fundamental science ensure a wide range of skill and knowledge transfer within the consortium. Working in close collaboration with our SME partner will allow early career researchers to gain an invaluable experience in bringing research to real life applications and to broaden their future career choices. The research has significant potential for life-changing applications in cardiology, especially relevant to adult and aging population. Solution to this problem will help to cut costs in European health care systems and improve quality of life of millions of people.

Mots clés : nonlinear time series, statistical analysis, fibre based sensors, diagnostic data analysis, heart failure

Participants :
- University of Brescia (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 63000.0 €
- Novosibirsk State University (Russie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 94500.0 €
- Diasens doo beograd (Serbie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 76500.0 €