Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet OSTers (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Congenital disorders of glycosylation (CDGs) are genetic defects affecting the assembly and addition of asparagine (N)-glycans to proteins. N-glycosylation occurs in the endoplasmic reticulum by the Oligosaccharyl transferase (OST) complex. Mutations in components of OST complex are identified in CDG patients with broad clinical features. However, the mechanisms by which OST mutations cause phenotypic heterogeneity are not known. Moreover, in vivo studies on the precise role of individual OST components in animal development are lacking. In this framework, the goal of this proposal is to understand the function of OST complex during animal development, with a focus on their role in the regulation of developmental signaling pathways. The final aim will be to provide insights for deciphering some aspects of patients’ clinical features with OST mutations. This might lead to new frameworks for targeted therapeutic manipulation.

Mots clés : congenital disorders of glycosylation  n glycosylation  bmp signaling

Participants :
- University of Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183473.28 €
Projet VESAFE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Connected and autonomous vehicles (CAV) holds great potentials for road safety and efficiency, but two major barriers need to be removed before its potentials can be fully unleashed: significantly enhanced vehicle to vehicle (eV2V) services with millimetre wave (mmWave) communications and reliable cooperative perception with autonomous vehicles (AV) sensors. However, the directional connectivity of mmWave presents new challenges for the whole protocol stack of V2V networks, while reliable cooperative perception requires novel design of deep learning (DL) models for object detection and fusion of sensor data from neighbour AVs. The above challenges underpinned by CAV demand a holistic design and tight integration of connected vehicles (CV) and AV technologies. This innovative and multi-disciplinary project VESAFE will train the outstanding Fellow candidate to tackle the key challenges with complementary expertise and realize the full potentials of CAV. A novel cross-layer design is proposed for the research of 5th generation (5G) eV2V schemes with mmWave and reliable cooperative perception for advanced CAV safety applications: the eV2V schemes are AV oriented and greatly assisted by the AV cooperative perception, and the reliable cooperative perception is boosted by the awareness of V2V network conditions. And this project propose a novel integrated evaluation of 5G eV2V and CAV applications to support system design and performance characterization. Through the cutting-edge research, this innovative project will produce robust eV2V schemes and reliable cooperative perception solutions, make breakthrough on 5G V2V and CAV safety applications. It will significantly improve the Fellow’s employability and career prospects, strengthen knowledge transfer, boosting the research and innovation (R&I) capacity and research quality, therefore contributing to Europe’s competitiveness and growth in critical sectors of 5G/6G and AV.

Mots clés : 5g mobile networks, connected vehicles, connected autonomous vehicles

Participants :
- University of Essex (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet PredAMEG (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Considerable evidence supports the notion that the brain actively predicts incoming sensory events which are compared with internal models. However, the underlying mechanisms remain unclear. The goal of this project is to identify the role of neural oscillations during predictive processing in a hierarchical auditory network using Magnetoencephalography (MEG). I will examine oscillatory activity during the encoding of predictable auditory events and the subsequent detection of unpredictable deviations in a modification of the roving standard paradigm containing nested levels of acoustic regularities. Specifically, I aim to identify the specific frequency channels underlying the signalling of sensory predictions and prediction-errors across the auditory hierarchy. In addition to studying predictive processing during normal brain functioning, the proposed project will examine aberrant auditory predictive processing in schizophrenia, a disorder characterized by profound abnormalities in auditory perception. Accordingly, the outcomes of this project will not only impact on our understanding of the principles of normal brain functioning but may also have implications for future clinical and translational research.

Mots clés : predictive coding, auditory perception, neural oscillations, schizophrenia

Participants :
- University of Glasgow (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet MOPTOPus (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : CLOSED

Contactless manipulation of nanomaterials to map critical properties at their native length scale is of major importance for the study of the local structure-properties relationship. To this aim we will implement plasmonic degenerately doped metal oxide nanocrystals (MO NCs) with carrier densities around 10^21 cm^-3 and localized surface plasmon resonances (LSPRs) in the near infrared (NIR) as optically driven contactless nanostructures to dynamically manipulate local optoelectronic properties. Capacitive charging upon photo-doping enables the optical regulation of their carrier density, leading to contactless nano-gates for the nanometer scale manipulation of local potentials. Intentional charge release upon plasmon induced ‘hot’ electron extraction through excitation of the LSPR facilitates local charge transfer, resulting in a light driven nano-manipulator converting local light energy into electrical energy based entirely on optical triggers. Appropriately designed MO core-shell NCs will be prepared to establish photo-doping, charge storage and ‘hot’ electron extraction, and to extract critical physical and chemical parameters. The nano-devices will be employed to actively manipulate and elucidate the local optoelectronic properties of layered two dimensional materials which are extremely susceptible to local electrostatic field and potential changes. Hybrid structure formation is accomplished by depositing the MO nano-devices on top of the nanostructure, while nanoscale manipulation of the local potential and/or localized charge transfer is triggered by light pulses, leading to a contactless nano-device for local optoelectronic manipulation. The successful participation in the MCIF will enhance the innovative potential of the fellow diversifying her individual competences, allowing her to acquire new knowledge and open career possibilities by establishing a new research vision with high potential for applications in interdisciplinary fields.

Mots clés : photo doping, plasmon induced hot carrier extraction, transition metal dichalcogenides, metal oxide nanocrystals, layered two dimensional materials, optically driven nano device

Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 262269.0 €
Projet FORENSHYD (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Contaminant events disrupt stability and resilience of increasingly vulnerable soil and groundwater. Identifying where, when and how much contaminant spill is released into aquifers is critical for strengthening the competitiveness of EU in risk-reduction management, and Forensic Hydrogeology, a growing discipline that applies scientific knowledge in legal resolutions. Existing model solutions estimate the origin and affected area, but numerical challenges impose too restrictive assumptions to properly account for multiple sources or suitable aquifer characterization. The scientific goal of FORENSHYD is to develop a novel, flexible and reliable ensemble Kalman filter data assimilation method (EnKF) for the optimal identification of contaminant sources and occurrence of reactive pollutants in near-actual conditions. Latest assessed developments of Dr. Gómez-Hernández set EnKF as an excellent optimization tool for the simultaneous identification of the spatial variability of conductivities, the location, and the release function of polluting sources. A step toward coupling the algorithm with machine learning techniques may overcome ill-posed solutions, stemmed from nonlinearities between parameters and variables in the state equation, to solve kinetic-controlled reactive transport problems and to optimize data collection in groundwater observation network systems, a topic of renewal interest in administration and industrial sector. We test spurious effects of aquifer heterogeneity, reactive parameters, and initial/boundary conditions in synthetic scenarios, sandbox experiments and two demonstration sites. Transfer of this novel technology in well-reported, practical and universal open source packages will reinforce the leadership and employability in the global market of intersectorial and interdisciplinary European stakeholders. The societal value of FORENSHYD is to improve mitigation strategies, and clarify environmental liability, in liaises with Horizon 2020.

Mots clés : quantitative hydrogeology, data assimilation, ensemble kalman filter, machine learning, stochastic inverse modelling, reactive transport modelling

Participants :
- Universitat Politècnica de València (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160932.48 €
Projet VEiL (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Contemporary anthropogenic landscapes were shaped by centuries of human action. Land surveying and division were the first forms of widespread landscape engineering performed by pre-industrial societies. Among those, the most complex was unquestionably the Roman Centuriation, which still characterise the rural landscapes of many European countries. Notwithstanding its impact on modern European land organisation, the principles underlying the design approach used by Roman land commissioners are still largely ambiguous. The proposed project thus aims to illuminate the process of landscape engineering undertaken in antiquity by the Roman surveyors and contribute to the discipline of landscape engineering by injecting a new body of evidence into the debate about past land division and design in order to inform models of sustainable practice for contemporary landscape management. The project integrates archaeological, historical and geospatial information to investigate the forms, impact and endurance of complex engineering on the landscape of Aquileia (Italy), a major city of the Roman Empire. Imprinted with the Roman 'spatial signature', the Aquileian countryside provides an unparalleled opportunity to expand our current understanding and perception of the origins and advances of landscape engineering and its efforts to build sustainable responses to long-term environmental and socio-economic pressures. To achieve its research agenda, this study will develop new methods based on Artificial Intelligence for digitally identifying, collecting, integrating, managing and sharing diverse spatial and archaeological data that are key for the identification of the centurial system elements where they are no longer readily identifiable and will apply a novel approach for defining models of land division application and dynamics in antiquity.

Mots clés : land division, centuriation, roman archaeology, remote sensing in archaeology

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet EpiPurines (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Current epilepsy therapies, based on mediating excitation or inhibition, are ineffective in 30% of patients & have no impact on disease progression, demonstrating an urgent need for new therapies. Mounting evidence showed the therapeutic potential of targeting the purinergic system during epilepsy with the disease-modifying effects observed via targeting the P2X7 receptor & Adenosine kinase (ADK) being a promise. P2X7 & ADK are increased in the brain in experimental models of epilepsy and in patient brain. Further, data showed anticonvulsive & anti-epileptogenic potential of targeting P2X7 or ADK. To advance these findings towards a clinical application, results must be replicated in animal models mimicking closer the human condition (e.g.TBI model) and effects must be tested in human cells (hiPSC). Importantly, while there is now compelling evidence demonstrating the therapeutic potential of targeting both P2X7 & ADK separately, a combined treatment, targeting both simultaneously, may lead to better seizure control & suppression of epilepsy. By using relevant animal models of epilepsy and hiPSC, EpiPurines will establish the disease-modifying potential of targeting different components of the purinergic system during epileptogenesis, thereby establishing P2X7 & ADK-targeting as potential treatment for epilepsy. To achieve this, EpiPurines brings together, for the first time, a team of experts in purinergic signaling from different research fields (Adenosine & ATP-signalling) & industrial partners. This highly interdisciplinary & intersectoral approach will contribute significantly to the understanding of purinergic signalling during seizures & epilepsy providing novel therapeutic approaches. The skills acquired during the research project, the excellent training record of the supervisors & host institutions and the outstanding resources for learning & development available at RCSI & RU will give me the tools necessary to become a highly employable neuroscientist.

Mots clés : purinergic signalling, traumatic brain injury, epilepsy, p2x7 receptor, adenosine kinase, animal models, ipscs

Participants :
- Rutgers, The State University of New Jersey (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 257561.28 €
Projet PRIISM-HD (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Currently, there is an urgent need to understand the pathogenesis underpinning insulin resistance (IR) and type 2 diabetes (T2DM), due to their dramatically increasing prevalence. Glucocorticoids (GCs) are potent modulators of skeletal (Sk) muscle insulin sensitivity, as exemplified in patients with GC excess, Cushing’s syndrome, who develop IR and T2DM. Importantly, increased GC generation locally in muscle may contribute to the phenotype in T2DM patients. Although the precise molecular mechanisms driving IR in both T2DM and Cushing’s syndrome are unclear, dysregulated lipid metabolism is a common feature of insulin resistant muscle. This proposal aims to identify how GCs regulate intramyocellular lipid metabolism, and how this impacts on muscle insulin sensitivity. In addition, we will test a novel therapeutic target involved in mediating the metabolic actions of GCs, recently described by Dr Carolyn Cummins, the supervisor of the outgoing phase of this proposal. The complementary expertise in integrative molecular physiology of Dr Cummins, and of the Experienced Researcher, Dr Stuart Morgan, dovetail nicely within an established multi-disciplinary collaborative network of pharmacologists, molecular biologists and analytical chemists at the University of Toronto that have a unifying goal to uncover novel mechanisms regulating IR. Specifically, this proposal employs a systems approach by integrating both in vivo and in vitro pharmacological and genetic manipulation, with lipidomic/proteomic profiling and in-depth molecular characterisations. This novel strategy will significantly advance our understanding of key processes regulating insulin sensitivity in Sk muscle, a process essential for normal glucose homeostasis.

Mots clés : insulin resistance, skeletal muscle, type 2 diabetes, cushing s syndrome

Participants :
- University of Toronto (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 255349.8 €
Projet Talent4BBI (Horizon 2020, appel à projets 2020)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

Cutting-edge PhD training in bio-based industries is a critical necessity to tackle the challenges, risks and strategic opportunities of the rapidly evolving European bioeconomy. Talent4BBI will provide a unique opportunity for Early Stage Researchers to develop key skills, competencies and experience required by bio-based industries through a targeted programme for future bioeconomy leaders. Coordinated by BiOrbic Bioeconomy SFI Research Centre at University College Dublin (Ireland) over a 60-month programme duration, 11 ESRs will undertake PhDs of 48 months cohosted by academia and industry. ESRs will be recruited and co-hosted by a consortium of 16 partners across 8 Member States and 1 Associated Country (7 universities and 9 leading bio-based industries) with a wealth of collective experience in training talented mobile researchers. 3 additional partners will contribute their expertise to the training programme. In line with the principles set out in the Charter and Code and with the EU Principles for Innovative Doctoral Training, a unique practice-based pedagogy will enable graduates to thrive in an industrial and academic research setting and enhance ESR career opportunities in line with the MSCA COFUND work programme objectives. Talent4BBI’s selection process will be guided by principles of openness, transparency, merit, impartiality and equality for the ESRs. Talent4BBI will impact the European Research Area through developing a uniquely qualified and career-driven talent pool, driving effective cooperation between industry and academia, and boosting the development of bio-based industries.

Mots clés : bio based industries, bioeconomy

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1193280.0 €
Projet CyberSure (Horizon 2020, appel à projets 2016)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : SIGNED

CyberSure is a programme of collaborations and exchanges between researchers aimed at developing a framework for creating and managing cyber insurance policy for cyber systems. The purpose of creating such policies will be to enhance the trustworthiness of cyber systems and provide a sound basis for liability in cases of security and privacy breaches in them. The framework will be supported by a platform of tools enabling an integrated risk cyber system security risk analysis, certification and cyber insurance, based on the analysis of objective evidence during the operation of such systems. CyberSure will develop its cyber insurance platform at TRL-7 by building upon and integrating state of the art tools, methods and techniques. These will include: (1) the state of the art continuous certification infrastructure (tools) for cloud services developed by the EU project CUMULUS; (2) the risk management tool of NIS enhanced by the NESSOS risk management methodology; and (3) insurance management tools of HELLAS. The development of the CyberSure platform will be driven by certification, risk analysis and cyber insurance scenarios for cyber system pilots providing cloud and e-health services. Through these, CyberSure will address the conditions required for offering effective cyber insurance for interoperable service chains cutting across application domains and jurisdictions.

Mots clés : cyber insurance, security certification, security risk analysis, cloud services, e health

Participants :
- Cablenet communication systems ltd (Chypre) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 270000.0 €
- Hd insurance ltd (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 270000.0 €
- Dgs spa (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 270000.0 €
- National Research Council (Italie) — Partner, beneficiary, Recherche, subvention : 270000.0 €
- Foundation for Research and Technology Hellas (Grèce) — Coordinator, beneficiary, Recherche, subvention : 297000.0 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 270000.0 €
Projet RACING (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Cyclobutanes are common motifs in natural products and are increasingly important in medicinal chemistry since they can orient substituents along precise vectors. However, methods to construct cyclobutanes are less developed in comparison to their smaller and larger rings. Consequently, novel methods to access functionalized cyclobutanes are highly desirable and would be of considerable value for the discovery of new bioactive compounds. In the last decade, the host group and others have contributed significantly to the development of boron 1,2-migration chemistry which has found numerous applications in organic synthesis. Normally, 1,2-metallate shifts in boronate complexes are induced by α-leaving groups or by reactions of alkenyl boronates with halogens, π-acidic metals, or radicals. Herein, we are proposing a fundamentally new strategy to induce 1,2-metallate rearrangement, via a ring expansion of vinyl cyclopropyl boronate complex activated by an electrophile or by photoredox or transition metal catalysis. This novel process would lead to highly versatile boronic ester containing cyclobutanes, which can be transformed into other valuable functional groups. Furthermore, we plan to use chiral ligands in combination with palladium catalysis in this novel process, leading to enantioenriched chiral cyclobutyl boronic esters. These novel methodologies not only benefit from the formation of highly functionalized cyclobutanes, but also lay solid foundations for the development of other ring-expansion induced 1,2-metallate rearrangements. The scope of these processes will be carefully investigated, and mechanistic studies of the photoreaction will be carried out using advanced physical/chemical methods. Finally, this project will enable significant knowledge transfer between the host and researcher, while forging new academic networks within the scientific community.

Mots clés : cyclobutanes, boron chemistry, photoredox catalysis, perfluoroalkylation, palladium catalysis

Participants :
- University of Bristol (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €