Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SHINE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The growing interest for the integration of renewable energy sources, as solar energy, in the global energy mix, increases the need of developing of new methods that will assist on the up-scaling and demonstration of efficient energy storage and conversion technologies. In this regard, advanced modelling methods can be an indispensable tool towards this effort. SHINE aims at developing a holistic numerical methodology – by using in-house codes coupled with commercial software– that will boost the cost-efficient and sustainable electricity production and storage at unprecedented ultra-high temperatures (> 1000 oC). The stepping stone for the modelling activities will be a compact latent heat thermophotovoltaic device recently patented in UPM targeted for energy storage and production at ultra-high temperatures. The core components in such a device are the latent heat thermal energy storage system and the thermophotovoltaic device. The modelling methodology will integrate rigorous multi-physics models (fluid dynamics, heat transfer and optoelectronics) targeted at a component level into a reduced order model (ROM) by using multi-variable polynomial functions. Key in the proposed methodology is the validation of the rigorous models through in-house measurements at ultra-high temperatures that will be undertaken at the host organisation. Key as well is the production of the multi-variable polynomials through artificial neural networks that will be undetaken during the Secondment phase. The whole project is highly interdisciplinary because it integrates highly interrelated diverse disciplines (physics, engineering, optoelectronics, thermo- and fluid-dynamics, photovoltaics and thermal storage, and artificial intelligence-AI) as well as know-how from experiments is a single holistic approach. Once developed the ROM will be used to predict the whole system's performance as being part of a solar-to-heat-to-power and a power-to-heat-to-power concepts.

Mots clés : ultra high temperature energy storage and conversion latent heat thermal energy storage

Participants :
- Idener (Spain) (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université polytechnique de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet SMART-AML (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Acute Myeloid Leukemia (AML) is an aggressive hematologic malignancy characterized by the uncontrolled proliferation of myeloid cells, which hijack the bone marrow (BM) and compromise its physiological functions. AML prognosis remains poor, with <10% of patients above 60 years old surviving after 5-years. Recent discoveries have revealed the key role of BM microenvironment in harboring and protecting leukemic stem cells from chemotherapy, contributing to AML relapse. Therefore, targeting the hijacked BM niche and transforming it into a “tumor-inhospitable” microenvironment represents a promising therapeutic strategy. In adults, bone marrow adipose tissue (BMAT) is the predominant component of the BM microenvironment, making it an appealing target. However, the role of BMAT in AML development, drug resistance and survival is still controversial.  With SMART-AML, I aim at identifying AML cells-related changes within the BMAT/BM microenvironment, to introduce BMAT manipulation as therapeutic strategy to sensitize leukemic cells to chemotherapy. To achieve this goal, I will exploit state-of-the-art bioprinting technologies to engineer a perfusable, humanized bone/BMAT 3D biomimetic microenvironment. Patient-derived AML cells will be cultured within the engineered platform to characterize the AML-induced BMAT changes in a controlled environment, with limited variables. Finally, BMAT will be manipulated (i.e. expanded or reduced), to determine the potential of this therapeutic approach on enhancing the efficacy of chemotherapy on leukemic stem cells and reducing the chance of relapse. This project will prepare me to become a tenured scholar, strengthening my academic profile and enabling me to establish myself as an independent principal investigator with a research line on advanced bone disease modeling. It will also create opportunities to perform cutting-edge research at the intersection between tissue engineering and cancer research.

Mots clés : bioprinting, biomimetic microenvironment, acute myeloid leukemia, bone marrow adipose tissue, bioreactor

Participants :
- University Medical Center Utrecht (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
Projet OrganoidsFHeartbreak (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

This project is a proof-of-concept study for organoid drug testing platform for disease modeling of cardiac fibrosis. I am going to develop a cardiac organoid on chip platform for disease modeling of cardiac fibrosis to identify the molecular mechanism of the pathologic interplay between endothelial cells, cardiomyocytes and cardiac fibroblasts, and its regulation by specific drug treatments. This model will be based on cardiac organoids previously developed at the host lab modified with endothelial cell component. Organoids with and without endothelial cells will be a tool for identification of endothelial contribution in cardiac fibrosis. Molecular mechanisms will be identified through selective interventions in known fibrotic pathways, with special focus on the Renin-Angiotensin-Aldosterone System. In addition, validity of this tool for drug testing will be established by proof-of-effect of known medications on fibrotic molecular phenotype and cardiac function. The platform will be designed as medium through-put for patient treatment optimization (precision medicine) and drug testing. Collectively, it has the potential to replace animal models in mechanistic research and drug development. The host lab is the perfect fit for this project. It has been on the forefront of cardiac organoid research and their previous work is the cornerstone for the cardiac organoid model used here. They possess the latest equipment for on-chip organoid cultivation and have extensive experience with augmentation and optimization of biopolymer hardness to simulate fibrotic environment. Additionally, Prof. Sluijter’s professional network of contacts and cooperation with local university spin-off companies provides the opportunity to investigate the interest of the industry in application of this project by scale-up of our drug testing platform for high through-put organoid drug screening platform.

Mots clés : human induced pluripotent stem cells, cardiomyocytes, cardiac fibroblasts, endothelial cells, angiotensin converting enzyme, tumor growth factor beta 1

Participants :
- University Medical Center Utrecht (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
Projet ATESCA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

The ATESCA (Ambient Temperature Extremely Sensitive Radiometer for CubeSat Applications) project seeks to advance radiometer technology by achieving highly sensitive microwave detection for space-based applications, such as radio astronomy and Earth observation, without the need for cryogenic cooling of the detector. This project is particularly focused on improving the detection of microwave radiation from the ozone of earth’s atmosphere and from the cosmic microwave background (CMB). ATESCA radiometers utilize a nonlinear optical upconversion process to transfer weak microwave signals into the optical domain. This process is intrinsically noiseless, and it has been shown theoretically that a good signal to noise ratio can be achieved even when the whole setup is sitting at room temperature (opposed to direct detection of the microwave radiation). The nonlinear upconversion process is intrinsically weak. Hence the team plans to employ whispering gallery mode resonators, which support resonances in both optical and microwave domains to significantly improve conversion efficiency. It has been shown theoretically that with the planned implementation, a photon conversion efficiency from the microwave (> 100GHz) to the optical domain of 1% can be achieved. This will enable the proposed radiometer with high sensitivity but would also be interesting for future quantum technology. This is a planned collaboration between a group in Madrid, Spain (UC3M) and Dunedin, New Zealand (UoO). The researcher will demonstrate the proposed conversion efficiency and hence sensitivity on a benchtop experiment and, afterwards, will implement the system into two actual payloads for CubeSat missions to demonstrate the radiometer.

Mots clés : optical resonator, whispering gallery mode resonator

Participants :
- Université Charles-III de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 280995.36 €
- Université d'Otago (Nouvelle-Zélande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet HICODY (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

The mathematical analysis of collective dynamics has experienced a prominent growth in the last years leading to new frontiers with cutting-edge fields in physics, biology and social sciences (e.g. complex networks, active matter or crowd dynamics). The deep breakthrough is that unveiling self-organization in a large group of agents can be tackled using strong mathematical methods from nonlinear and nonlocal PDEs, like harmonic analysis, energy methods, optimal transport and fluid mechanics. HICODY aims to go beyond the classical restrictive case of pairwise interactions. Indeed, recent advances in neural networks suggest that higher-order interactions are often needed to properly shape collective dynamics. Classical techniques break down in this setting, thus requiring innovative methods. This proposal is divided into three blocks. The first one aims to derive the rigorous kinetic and fluid-type PDEs of statistical mechanics from the underlying microscopic description to represent higher-order interactions at larger scales. Besides, the formation of patterns from multiple interactions will be analyzed in several examples of velocity alignment and synchronization dynamics. The other blocks integrate an interdisciplinary approach which combines analytical and computational tools to face the demanding technical level in two innovative applications: neuroscience and developmental biology. First, novel activity patterns will be explored in large ensembles of neurons with multiple interactions; second, a new PDE for filopodia-mediated morphogenesis will be rigorously derived supported by empirical evidence, contrarily to Turing’s theory based on free diffusion. As an evidence of the researcher capabilities, he has pioneered techniques to derive hydrodynamic and mean field limits in flocking and synchronization models with pairwise singular interactions. The project will be developed alongside his supervisor, who is expert in nonlinear PDEs and mathematical biology.

Mots clés : kinetic equations, hydrodynamic equations, many particle systems, collective dynamics, self organization, synchronization, mean field limits, hydrodynamic limits, complex networks, morphogenesis

Participants :
- Université de Grenade (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
- Université nationale de Séoul (Corée du Sud) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet INSKILLS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The rapidly changing demographic composition in Europe, characterised by an aging population and a decrease in birth rates, poses significant social and economic challenges for European states (e.g. not having a younger population in the labour force, and increased pressure on health services by the older population). Attracting highly skilled migrants (HSM) has become an essential means of addressing these challenges, and a number of countries have adopted strategies specifically targeted at attracting and retaining HSM. The project investigates the facilitators and impediments to the labour market inclusion of highly-skilled migrant spouses (HSS) through a comparative perspective of Italy and Norway. At the macro level, I ask (RQ1): What are the policies, practices, and programmes that focus on including HSS in the labour market and how well tailored are they to the needs of HSS? At the meso level, (RQ2): What is the role of employers, employment agencies and rights-based organisations in addressing the challenges that HSS encounter? Finally, at the micro level (RQ3): What career adaptability strategies do HSS develop to overcome the difficulties in finding and retaining jobs? The methods employed include semi-structured interviews with HSS, employers, employment agencies, employee associations, practitioners and political decision-makers, combined and triangulated with policy document analysis. The research findings will lead to policy recommendations as to how HSS can be better included in the labour market in Italy, Norway and Europe at large.

Mots clés : skilled migration, spatial mobility, third country nationals, italy, norway, labour market

Participants :
- Université de Padoue (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- BI Norwegian Business School (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226751.04 €
Projet WOMENWRITERS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Today issues vital to women are on the public agenda: equal pay, childcare, domestic abuse, breast cancer research and curricular revision with an eye to the inclusion of women. These recent achievements have their origins in things women (and some male supporters) said - or rather wrote - for the first time 600 years ago. Women writers began to emerge as a collective, non-occasional, literary phenomenon in the long 16th century (1490-1610). While the development was to an extent pan-European, its centre of gravity was undoubtedly Italy. The activity of women writers has been well documented by historians and scholars of literature. However, unlike their male counterparts, interest in the self-fashioning and presentation of women writers in portraits has been only sporadically touched upon. The project WOMENWRITERS will pursue 3 objectives: a) to assemble the intellectual biographies of 18 women writers included in 17 anthologies of poetry published in Venice (1545-1590), by detecting the strategies of self-fashioning in their published works; b) to collect and classify female portraits from the 16th century, in different media, on the basis of their association with the names of women writers, according to internal (inscriptions, attributes) or external (later traditions) evidence; c) to make a final assessment of the formal and visual strategies of self-fashioning adopted by women writers active in the long 16th century, and to provide the first quantification and classification of their portraits. The general goal of WOMENWRITERS is to improve our current understanding of the role of women in the cultural and artistic life of the early modern period. The project will challenge preconceptions on Renaissance misogyny, while at the same time addressing current anxieties on attitudes around gender. Furthermore, by focusing on women writers, it will raise awareness on the still highly relevant problem of female access to education.

Mots clés : earl modern women writers portraiture gender studies early modern art

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 235737.6 €
- Fai - fondo ambiente italiano (Italie) — Partner, associated partner, Autres, subvention : 0.0 €
Projet P4SPACE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Hybrid organic-inorganic perovskite solar cells (PSCs) as a well-known emerging thin-film photovoltaic (PV) technology are developing rapidly owing to their versatile optoelectronic properties. Outstanding photoconversion efficiency, high specific power (power to weight ratio), compatibility with flexible substrates and low-cost chemical-based manufacturing, and excellent radiation resistance of PSCs make them as a promising alternative for next-generation space PVs. However, compared with other practical space PVs, such as silicon and III-V multi-junction commercial cells, the research on PSCs for space environment is just in the infancy stage. The aim of P4SPACE project, is delivering of a sustainable PV technology for any present and future space environment application by developing and scale-up of the PSCs with high performance and durability in the harsh space environments.

Mots clés : perovskite solar cells, space environment, stability, modules, low cost manufacturing, up scaling, thin film photovoltaics, emerging thin film pvs, sustainability

Participants :
- Université de Rome « La Sapienza » (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 207609.6 €
- École polytechnique fédérale de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MitoSen (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Ageing-related diseases are tightly correlated with the accumulation of senescent cells. While the selective elimination of senescent cells is a primary therapeutical goal in the field, no clinically approved treatment currently exists, which constitutes an important research gap. Abundant evidence highlights how changes in mitochondria and cellular metabolism can be both cause and consequence of the senescent phenotype and suggests a possible role of this organelle in the specific targeting of these cells. Through a CRISPR/Cas9-based screening, Serrano’s laboratory identified Cyclophilin D (CypD) as a promising candidate target, since its inactivation leads to the selective elimination of senescent cells while being non-toxic for control proliferating cells. CypD is a matrix isomerase involved in various mitochondrial functions, including the regulation of cell death and the opening of the mitochondrial permeability transition pore, a non-specific pore in the inner mitochondrial membrane, by sensitising it to calcium and reactive oxygen species. Interestingly, additional functions have been described for CypD, including proteins scaffolding, as it binds to several mitochondrial proteins, apoptosis and mitophagy control, and regulation of the electron transport chain activity. This project will study CypD as a novel, non-invasive senolytic target and provide a molecular understanding of its modulation in senescence biology, taking advantage of the various well-established senescence models developed in Serrano’s laboratory, including human and mouse cells and in vivo models. The ultimate goal is to improve the therapeutic outcome of senescence-associated diseases by developing new strategies for the detection and elimination of senescent cells in patients.

Mots clés : ageing, senescence, senolytic, mitochondria, cyclophylin d, mptp, cellular metabolism

Participants :
- Institut de recherche en biomédecine (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet DynamAtt (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Our ability to explore the environment and to rapidly respond to external events depends on attentional processes, which set priorities based on our goals and on the salience of external stimuli. Distinct dorsal and ventral fronto-parietal networks process human visual attention, but little is known about their dynamics, because hitherto our knowledge mostly depended on fMRI, which has limited resolution. This proposal will utilize intracerebral recordings in human participants, a method with unrivalled spatial and temporal resolution, during the performance of attention tasks. Patients with drug-refractory epilepsy, exhibiting normal attention, who are implanted with depth electrodes in preparation for surgical treatment, will be recruited. The data collected will enable the Fellow to pinpoint the neural populations supporting different aspects of attention within each network, discern their temporal behavior and analyze the dynamics of the interaction between the two networks. The acquired results on the normal function of attention networks will guide the study of patients suffering from hemispatial neglect, a common disabling condition affecting attention functions, using non-invasive MEG recordings. The results will reveal the pathological alterations in attention networks' dynamics, resulting from right hemisphere lesions. Hence, the insights gained through these innovative investigations will extend our knowledge on attention processes in health and disease, and promote the development of better rehabilitation methods.

Mots clés : attention, intracerebral recordings, frontal cortex, parietal cortex, temporal cortex, occipital, cortex, human brain

Participants :
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 185076.0 €
Projet THE CROSSMODAL BRAIN (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Our ability to learn rests on the brain’s capacity to change. People who are blind since birth have to rely more strongly on the intact sense, hearing and touch, to interact with their environment. As a consequence, blind people often show superior abilities when it comes to discriminating sounds and touch. For example, they can distinguish different voices more easily. The blind brain shows large changes due to the lack of vision: the part of the brain that responds to visual input in sighted people is now activated by the processing of sounds and touch, which is called “crossmodal plasticity”. Not only blind people, but also sighted people sometimes show crossmodal activation of the visual cortex while perceiving sounds or touch. As many environmental events are multisensory in nature, e.g. we simultaneously see and hear a person, it is thought that all related sensory representations are activated in distributed networks across the brain – even if only one sensory input is received. The proposed project investigates, using the latest advances in ultra-high field imaging, the detailed underlying mechanisms of crossmodal activation of visual brain regions during voice perception in blind and sighted humans in order to understand how the brain adapts to experience.

Mots clés : crossmodal plasticity, blindness

Participants :
- Universität Hamburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162806.4 €