Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet DAMA-BIOX (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Overweight and obesity are risk factors for cardiometabolic diseases that can be partially prevented by adopting healthier lifestyles and eating habits, such as increased fibre intake and other bioactive compounds, such as phenolics. However, in the European Union, the proportion of overweight adults varies from 37 to 73%, averaging 53%. DAMA-BIOX uses apple pomace (AP) to recover, purify and encapsulate phenolic compounds (APF) and fibres to unveil the mechanisms of antioxidant and anti-inflammatory properties of the bioavailable fraction in 3T3-L1 adipocytes challenged with supraphysiological concentrations of palmitic acid to simulate obesity. DAMA-BIOX implements the use of an innovative humanised three-dimensional co-culture intestinal barrier model consisting of human enterocytes (Caco-2) and human fibroblasts (CCD-18Co) to recapitulate human intestinal absorption. The use and reuse of AP also target sustainable food production by harnessing agro-industrial side streams, representing a tangible solution to produce functional foods. DAMA-BIOX addresses this aim across four work packages, contributing to the environment, agroindustry’s circularity, and public health. DAMA-BIOX brings together cross-sectoral expertise, strengthens the European capacity for healthier and sustainable innovations, and generates new possibilities for food export. The prestigious fellowship will provide the experienced researcher (PF) with the first step in a new research field that will act as a platform to kick-start the future international academic career. The University of Limerick is the place of renowned subject experts, and exposure to international collaborators will provide the PF with a unique opportunity to grow as an independent researcher.

Mots clés : food science zero waste food innovation phenolics bioaccessibility bioavailability inflammation antioxidant

Participants :
- Université de Limerick (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
- université catholique du Sacré-Cœur (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SANTE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Peritoneal metastasis (PM) is considered as the terminal stage of metastatic colon cancer, with still poor median survival rate even with the best recent chemotherapy (Chem) treatment suggesting the need for advanced methods to assist with the early diagnosis and treatment. However, the newest methods combine cytoreductive surgery with hyperthermic intraperitoneal Chem (HIPEC), which uses mild hyperthermia (Hyp) by circulation of a hot fluid to boost the diffusion and cytotoxic effect of drugs. A recent development in patients with unresectable PM is pressurized intraperitoneal aerosol Chem (PIPAC) that combines a diagnostic laparoscopy with locoregional administration of Chem as an aerosol. Non-selective biodistribution, low bioavailability, high drug concentrations, limited drug circulation time, and various side-effects limit the utilisation of HIPEC and PIPAC. Innovative drug delivery system with the controlled drug release at tumour site can enhance the therapeutic efficacy. Utilisation of nanoparticles (NPs) as carriers to deliver drugs with the possibility of tagging them with targeting agents will overcome the off-site toxicity. Cyto/hemocompatible magnetic hybrid NPs (Silver sulphide-Iron oxide) with luminescence in the near-infrared region for combinational therapy of peritoneal metastasis (SANTE) project aims to develop multimodal therapy approach for diagnosis and treatment of PM. It intends to enhance the efficacy of PM treatment using a combination of image guided remotely activated nanoHyp coupled with targeted Chem. Tumour targeted Ag2S will allow preoperative detection of microscopic or residual tumours to improve resection before Chem/Hyp. Iron oxide, targeting agent(cetuximab), and the chemotherapeutic drug(cisplatin) are all clinically used for the treatment of various type of cancers. The result of this fellowship will enable scientists in the PM field to translate the novel diagnostic and therapeutic methods into clinical practice and market.a

Mots clés : hyperthermia, chemotherapy, peritoneal metastasis, iron oxide, silver sulfide

Participants :
- Italian Institute of Technology (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
- University College de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Paris Cité (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet INCITE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The research aims to analyse the role of Unrra, Unesco and Fao in planning a new global order since World War II based on Education, Science and management of the Environment, looking at the expertise and proposals of their workers. The research will focus on the sustainable and inclusive vision of global development of those United Nations agencies during one of the worst historical catastrophes observing the international circulation of technicians, agents and scientists inside those institutions through a prosopographical study and their programs of relief. The project will contribute to the history of humanitarianism through a prosopographical approach instead of the usual institutional one. It looks at the stories of UN agencies’ workers to understand how they realise their principal mandates on a global dimension. Moreover, the research sheds light on the scientific and cultural heritage of the UN agencies’ global planning, humanitarian practices, and sustainable development projects. The objective is to understand their potential global contribution to two of the current political priorities of the European Union: “creating a more resilient, inclusive and democratic European society” and “making Europe the first digitally-enabled circular, climate-neutral and sustainable economy”. Comparative use of United Nations sources in New York, Unesco archives in Paris and the Fao ones in Rome will produce the first global development planners and technicians database. The dataset shared on a web portal will collect biographical information about UN agency workers and their projects. The web-based research environment will be openly accessible to historians, social scientists, policymakers, stakeholders, students, teachers and a wider public, opening new possibilities in the analysis of humanitarianism and the World History of the 20th century and the production of sustainable and rightful public policies.

Mots clés : humanitarianism united nations war sustainable development biographies

Participants :
- Université de Rome « La Sapienza » (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 288859.2 €
- Université de la ville de New York (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Organisation des Nations Unies pour l'Alimentation et l'Agriculture (Italie) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet HYSPECQS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

In the last years the field of optomechanics, which studies the interaction of light with mechanical oscillators, has advanced considerably. Many pioneering experiments have demonstrated the ability to achieve quantum control of meso- and macroscopic systems. However, the intrinsic Gaussian nature of optomechanical systems makes the creation of complex non-classical states of motion challenging. In order to access them a quantum non-linearity, such as an electronic spin, needs to be introduced. Achieving strong coupling between a spin and a mesoscopic mechanical oscillator would have far-reaching implications, from tests of the foundations of quantum mechanics to applications in sensing and quantum information. Despite several attempts, this regime has remained elusive so far because of limitations such as short coherence times or low spin-mechanical coupling rates. In HYSPECQS I will overcome the limitations on coupling rate and coherence time by using state-of-the-art platforms. The spin degree of freedom will be provided by nitrogen-vacancy defects in diamond, which can display hundreds of microseconds-long coherence times. The mechanical resonators, pioneered by the host group, are embedded in a thin silicon nitride membrane patterned with a phononic crystal. These resonators have been demonstrated to reach seconds-long coherence times at few tens of millikelvins. By functionalizing the resonators with nanoparticles generating high magnet field gradients, I will achieve strong spin-mechanical coupling, I will demonstrate sub-ms spin state detection with a mechanical resonator, and I will generate non-classical states of motion. The project will be carried out in the group of Prof. Albert Schliesser at the Niels Bohr Institute, Copenhagen. I will gain theoretical and experimental understanding of cavity quantum optomechanics, which will complement my existing expertise on spin physics and interferometry, thereby enhancing my scientific and professional profile.

Mots clés : optomechanics

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet MedCorP (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Mediterranean corals live in habitats with naturally high fluctuations of temperature and salinity, which could enable their survival under future extreme climatic scenarios. The nutritional status of corals is linked to the uptake of several micronutrients, which support cellular metabolism and growth. Among these, iron is a fundamental micronutrient for respiratory and photosynthetic processes. Although the iron concentration in seawater can be extremely low, Mediterranean coastal waters are subject to large quantities of nutrients, including iron, via runoff discharge from land. Most corals require a certain amount of iron to support their metabolic processes, but the assimilation rate, critical thresholds, and the allocation of iron in different spatial compartments of corals remain to be studied. This project aims to describe the effects of elevated temperature and iron enrichment on the microenvironment and ecophysiology of corals from the Mediterranean Sea through a novel combination of high-resolution microsensing technologies, bioimaging, and nanoscale spectrometry to explore coral metabolism at the microscale level. By measuring their metabolic responses during elevated temperature and iron availability, I will quantify the role of inorganic iron for coral cellular metabolism, develop a new coral health index for coral metabolic performance, and share this knowledge openly to target specific actions for stakeholders (e.g., government departments, environmental agencies, scientists). With this valuable fellowship, I aim to expand my scientific experience to assess coral health comprehensively at the microscale, which I strongly believe will be a novel way to observe and predict changes in the natural environment. The outcome will serve as a new tool to precisely understand the extent of environmental changes, in particular, the effects of ocean warming and iron concentration, predicting the consequences on the Mediterranean Sea in the short and long term.

Mots clés : coral physiology ecophysiology metabolism performance health index micronutrients iron labeling microsensing multi stress experiment ocean warming nanoscale spectrometry

Participants :
- École polytechnique fédérale de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre Scientifique de Monaco (Monaco) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet REGEN (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Climate hazards pose severe threats to the ever-increasing interconnection of power networks across borders. Research has focused on climate risks to electricity infrastructure at local or national scales, and thus has not captured the spread of power failures across borders and their ripple effects in the global economy. To identify vulnerable locations and prioritise adaptation investment, it remains a key task to take a global perspective to quantify the vulnerability of power networks to climate hazards. Two challenges remain for scaling up the risk analysis to a global scale: 1) the complexity of modelling power network interconnectivity and failure cascades at very large scales; 2) the difficulty in quantifying losses across economies while considering economic agents’ flexibility in responding to supply and demand fluctuations. REGEN proposes to combine interdisciplinary expertise from academic and non-academic sectors to address above challenges and assess the resilience of global power networks in a changing climate. The objectives are: 1) to simulate power network connectivity and the cross-border propagation of failures due to climate hazards; 2) to develop a new version of the agent-based model Acclimate to assess the wider economic and supply chain impacts of power failures; 3) to assess costs and benefits of adaptation solutions, and develop results into a framework to inform regulatory, investment and engineering decision-making. The project will be primarily conducted at the University of Oxford and supervised by Prof. Jim Hall FREng. Open-access vulnerability maps/datasets and open-source software developed in this project will contribute to EU’s power interconnection target of 15% by 2030 and UN Sustainable Development Goals (SDG7 and SDG9). Through this project, the candidate expects to build interdisciplinary networks and achieve the applied impact of his research, which will enhance his career prospects of leading a world-class research group.

Mots clés : energy networks, climate hazards, network modelling, global supply chains, climate adaptation solutions

Participants :
- Leibniz-Gemeinschaft (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 345234.9 €
- European Central Bank (Allemagne) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet ProtectedTrade (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : TERMINATED

Pressures on natural landscapes due to soybean and cattle ranching have been increasing in Brazil over the last decades. This is largely driven by exports, including to the European Union, making these commodities some of the most important threats to biodiversity and non-timber forest products. Some of these products can be used for medicinal and food security purposes by local communities, and often are managed either by women or men differently. Area-based conservation measures are an important global conservation strategy and include the newly defined “other effective area-based conservation measures” (OECMs). OECMs can play a larger role in nature conservation in areas managed by local communities, yet it remains unclear to what extent they are contributing to conservation. This project will evaluate the impact of soybean and cattle expansion in Brazil on biological and cultural diversity and gender, and the contribution of OECMs on their conservation. Specifically, I will (i) identify species used by local communities and assess their conservation status as well as potential gender-differences in their uses; (ii) analyze the impact of soybean and cattle ranching expansion on biocultural diversity and the potential gender-biased consequences; and (iii) evaluate the contribution of different OECM-types to the conservation of cultural and biological diversity. To do that, this action will combine methods and techniques across disciplines (literature review on the relationship between species and gender) and geoprocessing and statistical analysis (land-use change and matching analysis). Expected results include three scientific publications and outreach activities to amplify societal awareness about the impact of agriculture on culture and nature and provide evidence of how OECMs can support both biodiversity and the livelihood of women and men, being considered as a promising conservation tool in the next decade.

Mots clés : biocultural diversity, commodity trade, land use change, area based measures, amazon, cerrado, effectiveness, oecm

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet PATHWAYS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

Chemical transformations involve formation and breaking of bonds in molecules, and their rate is determined by the reaction pathway for converting reactants to products. The use of photoexcited plasmonic nanostructures to alter such pathways, hence improving the reaction economics, has recently emerged as a transformative solution to the extreme energy demands of traditional catalysis. Strong photothermal nanoheating and high-energy charge carriers can be optically induced in metal nanoparticles, creating a local environment where reactions occur at temperatures far below those of common catalysts and lowered energy barriers. Most plasmonic photocatalysts operate however in the steady state, which intrinsically restricts rates and photon usage, as the inherent dynamics of chemical bonds, catalyst surface, and light-matter interactions remain untapped. This project aims at introducing new theoretical approaches breaking the steady-state paradigm to drive reactions along thermal and nonthermal pathways with ultrashort pulses. A comprehensive numerical model will be developed to rationalise the dynamics at play and design metasurfaces (ordered nanostructure arrays) working as photocatalysts in the ultrafast regime. Pulsed (femto- to nanosecond) light will be used to induce transient localised heating and to enhance the photogeneration of hot carriers on timescales relevant to the chemical kinetics. The two effects will contribute to promote reactions with increased energy efficiencies: the intrinsic thermal nonlinearities of chemical processes will be leveraged to achieve rates out of reach in steady state, the dynamics of high-energy carriers will be tailored to unlock nonthermal channels with selectivity otherwise unattainable. The envisaged predictive time-resolved models will guide experimental efforts and provide data-comparable results to demonstrate new concepts for enhancing photocatalysis via ultrafast nanophotonics, opening routes in light-driven.

Mots clés : hot electrons, electron dynamics, thermoplasmonics, ultrafast pulsed light, photothermal catalysis, metasurfaces

Participants :
- Université Rice (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175737.12 €
Projet SLAC (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Seeing Like a City (SLAC) metaphorically assumes the city’s perspective, to explore visual media and filmmaking’s potential for knowledge production on cities and civic action within them. Intended as the entanglement of relations among human and non-human populations, it addresses existing vision problems within urban studies and planning. The project pursues an in depth critical study and structured integration of audiovisual methodologies in urban studies, to see how they can be key sites of urbanism in the making and produce change in the field. Capitalising on the generative intersections between filmmaking and urban studies, it seeks to visualize multiple, but often unseen elements, of city-making. In so doing, it aims to decolonize urban studies and re-politicize planning. It will focus on the specific declination of unseen that has to do with the city–nature nexus towards a more-than-human frame for urban studies. It will rely on sensory ethnography, affective multi-modalities in storytelling and participatory and collective filmmaking as applied at the Sensory Ethnographic Labs and the Film Study Center (FSC) at Harvard. Inspired by efforts to redefine urban studies through de/post-colonial notions and approaches, it will involve a secondment at the (C)artography Lab at Hamburg Universität (UUH). While there, the project will design an audiovisual work that I will develop during the return phase to Italy’s Department of Architecture and Urban Studies- DAStU at PoliMI, which will be the pilot project of a new audiovisual urban lab which will be born at DAStU thanks to the MSCA post-doc grant. The project’s novelty lies in this critical and action-oriented transdisciplinary aspect, mobilizing processes of radical openness (Sennett, 2018) and exchange between research in urban studies and audiovisual production as a potential tool of city-making, intended as that specific city design philosophy aiming at tuning the contemporary to the future (Laundry, 2009).

Mots clés : audio visual art applied to urban studies experimental filmmaking innovative methodologies decolonial turn human and non human nexus environmental justice

Participants :
- Université d'Hambourg (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Harvard (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €