Projet Melomanes (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Metastatic melanoma is a hard-to-treat disease and it remains as one of the most worrisome cancer. There is an urgent need to improve the current therapies (chemotherapy, radiotherapy) that have a limited efficacy. A single therapy is not efficient to tackle metastatic melanoma and a combination of therapies is thus emerging as a necessity to efficiently eradicate all cancer cells. Recently, the development of immunotherapies has shown promises, in particular chimeric antigen receptor (CAR)-T cells. Nevertheless, the physical barriers represented by cellular and non-cellular components of the tumor microenvironment combined to the abnormal tumor vasculature and high interstitial fluid pressure, hamper an efficient tumour infiltration of CAR-T cells. In this context, thanks to a network of 18 partners (including 10 non-academic partners), MELOMANES aims to train doctoral researchers for the development of a combined therapy exploiting the properties of magnetic nanoparticles to induce damage on the tumor microenvironment by magnetic and optic hyperthermia in order to facilitate the infiltration of CAR-T cells. This therapeutic approach combining hyperthermia and immunotherapy is versatile, as it could be also applied to other types of solid tumors. Research and transferable training of the doctoral researchers will be performed in a highly interdisciplinary, intersectoral, and international environment. In addition to acquiring skills related to the research project, they will be trained also in open science, communication and dissemination, responsible research and innovation, circular economy, ethics, data management, entrepreneurship, marketing, intellectual property, and gender dimension in research. Their competences will be validated through certification and qualification examination, allowing a new generation of highly skilled doctoral researchers to emerge with a high-level training in particular in the multidisciplinary field of nanomedicine.

Mots clés : functionalization immunotherapy life cycle assessment magnetic hyperthermia organ on chip photothermal therapy risk assessment t cell therapy toxicology tumor microenvironment

Participants :
- Ecqa gmbh (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 565387.2 €
- NovaMechanics (Cyprus) (Chypre) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 235080.0 €
- Université de Vienne (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 540662.4 €
- Bureau de contrôle et de gestion de la recherche et de l'innovation ( Cyprus Institute) (Chypre) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École polytechnique fédérale de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Turku (Finlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Hôpital de l'Université d'Oslo (Norvège) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 297748.8 €
- Université libre d'Amsterdam (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274370.4 €
- Université d'Oslo (Norvège) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Laboratoire fédéral d'essai des matériaux et de recherche (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Misvik biology oy (Finlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 286488.0 €
- First five consulting, s.a. (Portugal) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Cn bio innovations limited (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Instituto de Investigación Marqués de Valdecilla (Espagne) — Partner, beneficiary, Recherche, subvention : 251971.2 €
- Université de Cantabrie (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Catalan Institute of Nanoscience and Nanotechnology (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Keele (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Malsch TechnoValuation (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 175112.98 €
- Université Paris Cité (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Lithoz gmbh (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Strasbourg (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €