Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet COLLINEAR-FRACTURE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The groundbreaking discovery of the Higgs boson at the Large Hadron Collider rang the bell for the beginning of a new era of particle physics. Naturally, the ever increasing precision data from experiments demand precise theory predictions for many observables to test the ultimate validity of the Standard Model (SM); any significant deviations from the SM predictions will hint for new physics. Quantum chromodynamics (QCD) being the most fascinating non-Abelian gauge theory provides a promising platform in achieving this goal through higher order perturbative computations in powers of the strong coupling. Process independent singular elements associated to QCD factorisation of scattering amplitudes in both soft and collinear limits, also known as splitting amplitudes, are the key elements in organising and automating these higher order calculations for the theory prediction of a general jet observable. So, the high relevance of these splitting amplitudes strongly motivates the researcher for an ambitious proposal on further improving their theoretical accuracy. In particular, through this proposal the researcher will investigate the soft-collinear splitting amplitudes required to predict a jet observable at next-to-next-to-next-to-leading order (N3LO). The researcher will also be exploring the intriguing concepts of collinear factorisation breaking and its effect on the prediction of an experimental measurable quantity. Upon successful, this project will contribute to the purpose of bringing down the theory uncertainties to 1\% level together with many new ideas and techniques which will assist the researcher to create an independent future career and contribute to tighten the grip on N3LO calculation tools.

Mots clés : lhc, hadronic colliders, strong interactions, scattering amplitudes, collinear factorisation

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet PHYBATT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

PHYBATT covers the development of algorithms and models to be embedded in the BMS to allow the battery to operate within the safety boundaries at any time and in each battery operating mode. The models to be developed and embedded in BMS algorithms can be applied in real-time battery control for various applications, such as (fast) charging, peak shaving in the grid and ancillary services with energy storage, leading to an improved techno-economical offering. This adds a Vehicle to Grid (V2G) mode corresponding to many support situations.

Mots clés : battery management system bms , physical degradation model, v2x

Participants :
- The University of Melbourne (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Flemish Institute for Technological Research (Belgique) — Coordinator, beneficiary, Recherche, subvention : 175920.0 €
Projet ReSens-Nature (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

Exposure to nature and its sounds can relieve from stress, promote relaxation, and restore cognition. These restorative benefits persist even with exposure to Virtual Reality (VR) of nature and its calming sounds. It is the combination of visual and auditory exposure to these VR environments and their sounds that promotes restorative effects for hearing people. This means that Deaf and Hard-of-Hearing (HoH) people may be excluded from being able to receive the same restorative benefits that hearing people receive. Evidence shows that there can be cross-modal transfer in HoH people, whereby speech and sounds can be perceived and understood through vibrations on the skin or can be localised via visual cues in VR technologies. Through the ‘ReSens-Nature’ project, the Fellow will develop a novel VR experience, through which he will examine the restorative effects of vibrotactile and visual sensory supplementation of nature sounds in VR nature environments for Deaf/ HoH people. The objectives are to (i) Develop and establish the usability of this novel VR nature environment that uses vibrotactile and visual supplementation of nature sounds, (ii) Examine whether this novel VR nature environment is providing restorative benefits to Deaf/ HoH people in comparison to a regular VR nature environment without sensory supplementation and in comparison to hearing people. Understanding the effects of sensory supplementation for Deaf/ HoH in VR nature environments could help make VR and other technologies more inclusive for Deaf/ HoH people and people with other disabilities. The project will be completed at the GET Lab of Cyprus University of Technology, a world-leading lab on VR technology and Wellbeing. The Fellow will bring highly complementary expertise in Deafness, Audiology, and Clinical Trials. The proposed work will advance the Fellow’s research and management skills, expand his research networks, and enhance the development of his career as an independent researcher.

Mots clés : deaf wellbeing nature

Participants :
- Institut de technologie de Chypre (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 148488.0 €
Projet ACO-LC (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Liquid chromatography (LC) is a prominent analytical technique serving life-sciences, chemical and pharmaceutical sciences, which plays a key role in virtually all research and development concerned with liquid phase (bio)chemistry. The performance of pressure-driven LC has continuously increased during the past century, with improvements realized by ordering the packing and reducing the particle size. Now that the point is reached where sub-micron ordered packings can be reliably produced, the performance limitation of LC lies in the principle itself, more precisely in the slow mass transport of analytes between the field lines with varying cross-sectional Poiseuille velocity vectors. Distribution of analytes in the sample bands over different local velocities results in Taylor-Aris dispersion, an effect that becomes increasingly important at high velocities, or at low diffusion coefficients. ACO-LC addresses this lateral diffusion limitation by inducing acoustically generated lateral flows obtained in resonance mode. The resulting vortices in this so-called acoustic streaming regime carry the analytes much faster than purely diffusive processes, therewith reducing the dispersion dependency on size and mobile phase velocity. While the efficacy of this acoustic vortex LC methodology has been recently shown in microfluidic channels in the host group, the channel dimensions need to be scaled to the micron-scale range, with the resonance condition maintained. In ACO-LC, innovative geometrical approaches will be pursued to overcome frequency limitations of commercial piezoceramic actuators. Improved separations of glycosylated hemoglobin variants are aimed for in glass substrates, which are compatible with integrated UV-VIS absorption. This improved separation application is of interest to millions of diabetes patients for routine separations and tackles an additional separation challenge encountered in multi-ethnic groups.

Mots clés : chip chromatography, microfluidics, acoustofluidics, liquid chromatography, lab on a chip

Participants :
- Vrije Universiteit Brussel (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet SuMAM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Metal Additive Manufacturing (MAM), also known as 3D metal printing, has attracted a great deal of attention from scientists and industries due to its potential in the state-of-the-art production of complex-shaped designs in the transport industry. MAM is considered the fundamental technology for Industry 4.0 since it is a low-cost and energy-efficient processing method for metallic components with a minimal environmental impact. Nevertheless, the surface finishing of MAM components is uncontrolled during the fabrication, resulting in low corrosion-resistant components. So far, current post-surface treatments are non-eco-friendly, non-energy efficient, and the achieved corrosion resistance does not fulfil the service life requirements. In this scenario, the main goal of the SuMAM project is to achieve the full exploitation of MAM in the transport industry following the European Green Deal. Namely, as a major innovation, we will develop an innovative All-in-one methodology to achieve the highest corrosion resistance during printing, removing the need for post-treatment. We will combine two approaches: surface creating by (i) in-situ laser processing and (ii) incorporation of additives during printing to control the surface without affecting the bulk properties of the final components. Our target materials are four aluminium alloys and one stainless steel, widely used materials in the transport industry. This project is an outstanding opportunity for the fundamental advancement of MAM science by a technological and economically feasible methodology. The SuMAM project presents the best research scenario for Dr. Rubén Del Olmo Martínez (candidate) to further develop his scientific career. The SuMAM project is led by Prof. Dr. Ir. Iris de Graeve and Prof. Dr. Ir. Herman Terryn from the SURF research group of the Vrije Universiteit Brussel (VUB), with a proven outstanding track record in both academic and industrial sectors in the scope of the proposal.

Mots clés : metal additive manufacturing aluminium alloys stainless steel corrosion behaviour microstructure corrosion protection electrochemical analysis surface chemistry

Participants :
- Vrije Universiteit Brussel (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
Projet IONIC (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

This proposal concerns the fundamental properties of mixed ion-electron conducting polymers. These materials are biocompatible and conduct both ions and electrons, making them excellent candidates for bioelectronic applications interfacing with living tissue. The conductivity of these materials increases under bias by injecting ions and concerted doping of the semiconducting polymer. However, upon high doping the conductivity can no longer increase but rather decrease. The exhibited maximum, where any voltage change lowers the conductivity, amounts to an anti-ambipolar response which finds applications in biorealistic artificial neurons. The underlying mechanisms, however, remain unknown in part because of the inherent instability of highly doped polymer semiconductors. Without understanding the fundamentals of these materials, targeted optimization and development are inhibited. Additional complications arise from the complex environment in which they operate, consisting of ions and water. Their characteristics and response to doping are highly different in these conditions compared to ex-situ measurements, making in-operando characterization absolutely crucial. In-operando characterization is however not straightforward and requires specialized equipment. In this IONIC proposal, a research plan is described to investigate the fundamentals underlying anti-ambipolarity by designing and building novel in-operando measurement tools, and applying them to a uniquely stable ladder-type polymer. This unprecedented approach allows for characterizing, for the first time, the doping interactions throughout the anti-ambipolar regime. Project IONIC marks a major breakthrough in understanding organic semiconductor doping in electrolytes. The resulting general structure-property relations uncovered by the research described in this proposal will enable an intelligent design of material systems for exciting applications in bioelectronic interfacing and biomimicking circuitry.

Mots clés : conducting polymers, electrochemical doping, in operando characterization, mixed ion electron conductors

Participants :
- Université de Berne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Linköping (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet MECOMA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The MECOMA project aims to significantly improve hazard assessment of monogenetic volcanic fields (VF) by creating synergies between recent advances in landscape evolution modelling and the current understanding of scoria cones' volcanic structure and evolution. Assessing hazards from VF is more challenging than that of polygenetic volcanoes, as it requires understanding the spatiotemporal distribution of eruptions within the VF. Constraining temporal information is specifically challenging: radiometric dating of scoria cones (SC) provides, until now, the most "accurate" estimate of the date of their eruption, but it cannot be systematically applied to the hundreds or even thousands of SC within each of the many VF on Earth. Morphometry-based dating of SC provides an alternative. Research has shown that following the cone's emplacement, the volcanic edifice's morphology changes due to erosive processes. Parameters measuring the decrease of slope angle, the degree of gully incision, and cone irregularity are key indicators of erosion that can be quantified from Digital Terrain Models (DTM). However, some questions still need to be answered to use morphometric indicators as age estimators, such as the control of SC size and climate conditions on the time evolution of morphometric indicators or the trade-offs between diffusive and advective erosion processes. MECOMA project seeks answers to those questions by implementing numerical models to simulate erosion on cones under controlled erosive conditions and linking the results with an analysis of the morphologies of radiometrically-dated scoria cones from different VF exposed to various climatic conditions. As an outcome, I expect to provide tools and clear guidelines that contribute to implementing morphometry-based dating techniques in VF worldwide and, through my training at VUB, gain experience managing research projects and expertise in landscape evolution modelling and volcanic geomorphology.

Mots clés : monogenetic scoria cones, landscape evolution modelling, hazard assessment of dispersed volcanism

Participants :
- Vrije Universiteit Brussel (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
Projet Acyl-STEP-seq (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Regulation of transcription is orchestrated by a complex combination of histone posttranslational modifications (PTMs), but how their co-occurrence in the same cell regulate gene expression is still poorly understood. Recently, novel histone acylations have been identified, namely propionylation (pr) and butyrylation (bu). They co-exist with acetylation (ac), arise from cellular metabolism, and are key candidates to fine-tune chromatin activity and transcription. This project will answer fundamental questions on the role of acylations in gene regulation and their co-occurrence in single cells, and provide novel insights into metabolic disorders (propionic acidemia; PA), where histone acylations are altered. Through this project, I will generate the first genome-wide histone acylation map in single cells, functionally link their co-occurrence with gene expression, and establish the impact of a metabolic disease on histone acylations and transcription. Our preliminary data showed that histone H4K16ac/pr/bu play key roles in chromatin activity and could thus regulate transcription, and are impaired in livers of a PA mouse model. I hypothesize that acylations co-occurrence will regulate transcription, and altered propionyl-CoA metabolism in PA will impact H4K16 acylations, and consequently transcription. To achieve this, I will develop an experimental and computational framework for single-cell Simultaneous Transcriptome and Epigenome Profiling (sc-STEP-seq). With this approach, I will map H4K16ac/pr/bu and the transcriptome in single-cells, and integrate epigenomic and transcriptomic changes, in liver samples from PA mice. This interdisciplinary project will address a fundamental question in epigenetics: the functional relevance of histone PTMs regulated by metabolic state in single cells, advance the technology for single-cell multimodal epigenomic profiling, and provide for the first-time molecular understanding of histone acylations in a clinically relevant model.

Mots clés : histone acylations histone modification co occurrence single cell multi omics gene regulation metabolism epigenetic crosstalk animal model clinically relevant samples metabolic disorder

Participants :
- Helmholtz Zentrum München (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet NEXT-UP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

NEXT-UP involves the development of a cutting-edge proteomics analytical platform for untargeted mass spectrometry (MS) based proteome profiling doubling the chromatographic resolving power and delivering an unprecedented three-order magnitude increase in MS detection sensitivity. Key technological advancements include the development of a new generation of precision-engineered monolithic capillary columns, designed with a nanostructured flow-through pore system, which is compatible with ultra-low-flow (<20 nL/min) operation. In addition, an innovative microfluidic modulator chip will be designed and constructed to enable sample transfer in two-dimensional liquid chromatographic (2D-LC) separations on a nanoflow scale. Proof-of-Concept involves the comprehensive identification of plasma protein signatures in serum. Consequently, the NEXT-UP initiative aims to unravel plasma proteomics by revealing high-impact, low-abundance proteins, with the goal of advancing early disease detection, uncover disease mechanisms, and revolutionizing personalized treatments. The project will be conducted at the VUB having unique expertise in biocolumn and chip design/prototyping and nanoLC-MS omics in close collaboration with HZI providing relevant samples and knowhow in clinical (plasma-) proteomics, bioinformatics/statistics matching the demands in translational research and systems level approaches.

Mots clés : separation science serum proteomics two dimensional liquid chromatography

Participants :
- Helmholtz-Gemeinschaft (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Vrije Universiteit Brussel (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200400.0 €
Projet NEPHIMLEI (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Vector-borne diseases create considerable risks to human health. Leishmaniases are a group of neglected vector-borne diseases caused by protists parasites from the Leishmania genus. Approximately 350 million people around the world are at risk of being infected with Leishmania, and clinical manifestations in humans vary from cutaneous to visceral types. Leishmania is transmitted to humans by hematophagous female sand flies (Diptera, Psychodidae, Phlebotominae). Here we focus on Phlebotomus perniciosus, the natural vector of Leishmania infantum (the causative agent of visceral leishmaniasis) in the western region of the Mediterranean basin Europe. Leishmania cycle occurs in the sand fly midgut, where parasites must overcome natural barriers such as high activity levels of midgut digestive proteases, the competition with the native gut microbiota, and the activation of sand fly immune responses. Recently it was shown that insect immunity is under hormonal regulation; ecdysone hormone binds to its receptor (EcR) and triggers the expression of IMD immune signalling pathway-related genes. In sand flies gut, the IMD pathway controls Leishmania infection, but ecdysone's role in sand fly immunity and microbiota has never been studied. The NEPHIMLEI project, in a pioneering way, proposes manipulating P. perniciosus neuroendocrine system to affect sand fly gut immunity and microbiota intending the blockage of L. infantum development in the vector. Sand fly ecdysone function will be impaired by azadirachtin (an ecdysone inhibitor) oral treatment or silencing the EcR gene by RNAi. Also, sand fly immunity will be enhanced by suppressing repressor genes from both ecdysone and IMD pathways (Eip75B and caspar, respectively) using the CRISPR/Cas9 system. The altered ecdysone signalling could change P. perniciosus IMD-related immune responses, affecting microbiota and inducing sand fly resistance against L. infantum.

Mots clés : medical entomology, parasite vector interaction, leishmania, sand fly, neuroendocrine system, ecdysone, immune signalling pathways, crispr cas9, rnai

Participants :
- Université Charles de Prague (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166278.72 €