Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MultiSEAT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

MultiSEAT is a timely, participatory research project aiming to expand the frontiers of multilingualism toward socio-ecological and environmental research to contribute to education for nature protection and sustainability. Focusing on an indigenous multi-ethnic and multilingual school in Leticia (Amazon Trapezium), the project has three research objectives: 1. Design and implement multilingually a community-based participatory methodology allowing the collection of socio-ecological and ethnographic interactional data about food supply systems (FSS), deforestation (DEF), and ecotourism (ECOT); 02. Provide insights into the ideological stances (perceptions, attitudes, beliefs, and representations) that the school community and their families have on these socio-ecological issues; and 03. Design a pilot of three research-based Multilingual, Inclusive Teaching Sequences (MITS) to tackle FSS, DEF, and ECOT within the indigenous school. To achieve these aims, MultiSEAT will empower young people from the school through participatory research, engaging them in collecting quantitative and qualitative socio-ecological and ethnographic data. Analysing indigenous perceptions of environmental issues will provide insights into the complex relations between people, language, and nature. Also, by considering language as a plurilingual praxis in the design of the MITS, we will focus on what people do and can achieve with their multilingual resources as eco-linguistic capital. At project end, the scientific community will have an empirically based, comprehensive understanding of how the triangle ‘people-language-nature’ works. We will also provide expertise and guidance to non-indigenous local and global communities, policymakers, SMEs interested in bioeconomy, teachers, private/public funders, and stakeholders engaged in sustainability in Amazonia in the implementation of interdisciplinary methods to operate changes through multilingualism, education and environmental research.

Mots clés : multilingualism, social and environmental justice, youth empowerment, education for sustainability

Participants :
- Université nationale de Colombie (Colombie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut de recherche pour le développement (France) — Coordinator, beneficiary, Recherche, subvention : 258135.36 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet ARCHEM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The increasing volume and type of chemicals produced worldwide every year have the potential to cause severe ecosystem and human health problems. However, due to largely insufficient information regarding the identities, properties, and emissions of these substances, it is challenging to obtain a complete picture of global chemical pollution to aid in development and implementation of effective regulations. Despite the Arctic being pristine and distantly isolated from human activities, Arctic sediments function as a receptor for contaminants that are transported over long distances. Being ubiquitous far away from sources and in the Arctic requires that a chemical is sufficiently persistent, amenable to long-range transport (LRT), and produced in reasonably large quantities. Therefore, it is hypothesized that Arctic sediments can serve as a natural indicator to identify flaws or inefficiencies in current chemical legislation and prioritize persistent chemicals that require further regulation. The overarching aim of this project is to use state-of-the-art mass spectrometric tools together with high Arctic sediments to identify persistent contaminants of global concern, and then apply advanced statistical and modeling approaches to further understand their emission sources and LRT. This analysis will be used to: (a) Prioritize persistent contaminants of emerging concern based on increasing temporal trends recorded in dated sediment cores; (b) Identify major emission regions by analyzing the spatial heterogeneity of contaminants among circum-Arctic shelf surface sediments; (c) Identify dominant LRT pathways by comparing the chemical compositions of Arctic lake sites affected solely by atmospheric LRT versus marine sites impacted by mixed pathways. Results of this project will generate new knowledge on emission sources and transport of persistent chemicals of global concern while providing scientific guidance to improve chemical management and regulation policies.

Mots clés : arctic sediment nontarget analysis long range transport global chemical pollution receptor based analysis

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
- Amila de silva (Canada) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet MuTILDa (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Bilingual speakers of a Heritage Language (HL)—a language acquired naturalistically from early childhood, but distinct from the dominant language of the larger society—often display innovation and variation. Which exact factors account for this observation is subject of both theoretical discussion and empirical work. Cross linguistic influence (CLI) from the majority language plays an important role. However, the providers of input for the HSs are bilinguals living in the same dominant language society and potentially themselves HSs, whose linguistic patterns can be qualitatively different from those of the speakers from the homeland. To address the genuine contribution of the CLI in HL development, a good and largely underused comparison within the study of HLs would be the tripartite comparison of (i) HSs, (ii) their L1 immigrant input providers and (iii) speakers in the homeland. Most of psycholinguistics, including HL, research is conducted on languages endowed with writing systems and literacy traditions, an official status in some areas of their spread and a large, multi-million speaker population. Thus, what we know about HLs is largely based on a small sample of language pairs in a handful of sociolinguistic situation types. This incompleteness of coverage underdetermines the power of generalizations from empirical observations as well as their contributions to (psycho)linguistic theories. Therefore, it is urgent to take psycholinguistic studies out of the lab and focus on lesser-studied, including indigenous HLs. Using Mano as a case study, the objective of MuTILDa (Multilingual Transmission in Indigenous Languages in the Diaspora) is to study variation in linguistic knowledge of speakers of an indigenous HL in the diaspora, measured at the level of production and comprehension. It will be the first study of an indigenous language combining data from L1 immigrant generation, HSs and speakers in the homeland, as well as offline and online measures.

Mots clés : bilingualism, heritage speakers, cross linguistic influence, language processing, indigenous languages, reflexivity, syntax, african languages, french

Participants :
- Université de Lancaster (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet SEPAMP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The primary aim of SEPAMP is to delineate the economic characteristics defining the Neolithic period in the Maghreb, with particular emphasis on its final phase. The project investigates dietary habits, animal byproduct processes, and the tools employed in these activities to gain insights into technological specialisation and traditions. To achieve these objectives, I will conduct a comprehensive study, incorporating training on experimental protocols and use-wear analysis, of macro-lithic tools from Oued Beht (3400-2900 BCE), a Final Neolithic site in the Khemmiset province (Morocco). SEPAMP also aims to understand the decision-making processes and behaviours underlying the exploitation of local resources and land management, including cultivation and pastoral areas. Surveys around Oued Beht and geospatial analysis will identify raw material sources and areas potentially designated for farming and forage. Cost-effort and mobility pattern evaluations will be performed to understand how these communities interacted with their environment, including resource procurement choices and the distribution of economic activities within and outside the site. Thus, SEPAMP has the potential to enhance our understanding of the Maghreb's prehistoric communities significantly. Indeed, despite extensive efforts to interpret the neolithisation process in Northwest Africa, the development of socio-economic strategies and how late prehistoric communities approached the environment remain unclear. SEPAMP is then pioneering in understanding these phenomena, leading to new fundamental knowledge that can be compared with other Mediterranean areas, particurarly the Iberian Peninsula. It will also allow me to build hard and soft skills that I will benefit from for future academic and non-academic positions. This will be possible thanks to the high quality of the environment and training opportunities at CNRS - Trajectoires lab (Host) and the University of Cambridge (Secondment).

Mots clés : final neolithic maghreb macro lithic tools use wear analysis geospatial analysis

Participants :
- Université de Cambridge (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 226420.56 €
Projet VimAc (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Many cellular processes, such as cell shape, mechanics, and intracellular transport, rely on the organization of and interactions between cytoskeletal filaments (CFs). Intermediate filaments (IFs) are the least studied CFs, with little knowledge of their interactions with other CFs, particularly actin filaments (AFs). Vimentin, one of the most abundant members of the IF family, is upregulated during epithelial-to-mesenchymal transition and in epithelial cancers, its expression is associated with poor prognosis. Their hierarchical structure gives them great stretchability, which aids cells under large deformations. However, little is known about the deformation-induced unfolding of alpha helices and the parameters that drive it. This study focuses on understanding the origin of vimentin IF (VIF) stretchability by providing direct visualization of the unfolding of alpha helices within the VIFs and transition to beta sheets upon stretching under various conditions. Interactions of VIFs with AFs play an important role in cell mechanics and successful mitosis. Yet, if these filaments interact directly is still a matter of debate. The proposed project focuses on the interaction between VIFs and AFs to determine whether they interact directly at the filament level and, if so, what are the strengths of the interactions and their binding/unbinding rates. A combination of approaches and methodologies will be used, including in vitro reconstituted filaments, optical tweezers, tip-enhanced Raman spectroscopy, computer simulation. The knowledge gained from this project will help understand crucial physiological and pathological processes. The host and supervisor are well-equipped for this project, with the supervisor's expertise in understanding IF mechanics and function as well as interaction between CFs utilizing a multiscale biophysical approach. The PF will establish a unique niche in biophysics research and a robust CV for future grant applications and research positions.

Mots clés : cytoskeletal filaments, vimentin intermediate filaments, vimentin filament stretchability, actin filaments, in vitro reconstitution, quadruple optical tweezers, computer simulations, ters

Participants :
- Université de Göttingen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet GEMGEL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Meniscal tears are the most prevalent injuries of the knee joint and a major contributing factor to osteoarthritis (OA) development. Current treatments cannot effectively repair meniscus and only delay the onset of OA. Tissue engineering and regenerative medicine (TERM) approaches aim to promote the regenerative capacity of the tissue; however, this is hindered by the challenges of replicating the complex microenvironment of the tissue coupled with its intrinsic avascularity. My overarching aim is to develop an innovative zonal load bearing scaffold through melt electrowriting optimised using a machine learning approach to mimic meniscus biomechanics and extra cellular matrix (ECM) architecture. This will be integrated with corresponding zonal gene activated hydrogels using transcription factors implicated in meniscus regeneration to induce intrinsic regenerative capabilities. Prof. Khademhosseini (Terasaki Institute; outgoing phase), has extensive experience in hydrogels, 3D printing and stem cells. I will develop a 3D layered microfibre reinforced hydrogel scaffold mimicking the collagen architecture, biochemical and biomechanical properties of the meniscus and test its biological performance using human stem cells. Prof. Fergal O’Brien (RCSI; return phase), has extensive experience in scaffold-mediated gene therapy, particularly for musculoskeletal applications. Using techniques established in his group, I will develop zonally gene-activated scaffolds that can be used as a local delivery system in a radically new regenerative therapy for meniscus tears. Under the supervision of Prof. O’Brien and Khademhosseini, who will guide my Career Development Plan, I will develop key complementary skills in project management, entrepreneurship, commercialization, dissemination and leadership. These, along with advanced research competencies, will help me become an independent scientist, enhancing my visibility and competitiveness in in the TERM field.

Mots clés : scaffolds, hydrogels, biomimetic, bioprinting, meniscus, collagen

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 347465.76 €
- Université de Toronto (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet VirAgo (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Viruses infect all known living organisms, and the RNA interference (RNAi) response is one of the main defense mechanisms cells use against viruses. Even though we have a general understanding of the players involved in the antiviral RNAi response, with some systems more characterized than others, we still lack mechanistic details about the process. For example, in the C. elegans-Orsay virus pathosystem, loss of certain RNAi proteins can be advantageous for the virus, but it is still unclear whether this is because the virus highjacks the RNAi machinery for its own advantage or because the absence of certain RNAi proteins frees up resources which can then be used for antiviral defense. Moreover, preliminary results show that there are distinct viral RNAi silencing complexes, but the composition and function of these complexes is still unknown. Finally, the RNAi response seems to prevent multicellular viral colonization through yet unidentified mechanisms. In this proposal we aim to address these three open questions to improve our understanding of the role of RNAi in the defense response to a viral infection. We will perform a comprehensive analysis of the antiviral RNAi pathway and the Argonautes – the main effectors of the RNAi pathway –, their interactors and targets upon Orsay virus infection. We will use a multidisciplinary approach, combining in-depth analyses from virology, cell biology, genetics, genomics and developmental biology. This will be possible due to the collaboration between the researcher and the laboratories of Prof. Elena, the coordinator and virology expert, and Prof. Claycomb, the outgoing phase host and cell biology and small RNA regulation expert. The expertise the researcher will obtain goes beyond the research in either laboratory and will help her crystalize the unique research profile necessary to take her career to the next level of independence.

Mots clés : rnai, antiviral response, orsay virus, c elegans

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 223428.0 €
- Université de Toronto (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SELVANS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The conservation and improvement of forest soil resources is essential for achieving the UN Sustainable Development Goals and the EU Green Deal. Policy-makers and land managers need detailed information -quantitative and spatially explicit- on the effects of management strategies on soil condition and capability for supplying ecosystem services. The rise of digital soil mapping (DSM) and integrative modelling approaches have brought powerful tools for generating data-driven knowledge that can guide the decision-making process. SELVANS will implement an innovative DSM framework for assessing the effects of contemporary forest management on soil change, expressed as biogeochemical processes and microbial functions. The hypothesis is that the response of indicators of soil condition to management practices will differ by soil class depending on the biophysical environment, inherent soil properties and the legacy of land use history. Furthermore, SELVANS will investigate the links between anthropedogenesis and soil microbial functional diversity, and its effects on carbon and nutrient cycling. Soil classes and the degree of anthropogenic pressures on soil will be generated using data-mining algorithms, environmental covariates, time series of satellite imagery, national forestry inventory data and legacy soil data. Soil condition will be characterized with a comprehensive set of physical, chemical and biological soil properties (e.g., soil organic carbon, nutrients, soil microbial diversity and functioning) originating from completed and ongoing projects evaluating the functioning of forest soils. SELVANS' outputs will identify thresholds for decline in soil condition and risk of soil degradation, with an impact for forest management and conservation of soil resources. Finally, the capability of soils for delivering ecosystem services will be quantified applying the integrative modelling framework ARIES.

Mots clés : digital soil mapping, soil security, soil condition, soil capability, anthropedogenesis, forest management, soil functioning, biogeochemical cycling, microbial functioning, forest ecology

Participants :
- Basque Centre for Climate Change (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet NoLoHoLo (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

In this project, I will develop modern theoretical tools for non-Lorentzian geometry to advance our understanding of gravity and holography. Einstein's theory of general relativity describes gravity in terms of the curvature of a Lorentzian spacetime geometry. A similar geometric description of non-relativistic Newtonian gravity has been known for a long time. However, we have only recently figured out how the dynamics of such Newton-Cartan geometry can be extracted from a systematic expansion of general relativity. This gives a new and exciting approach to extracting predictions from general relativity using a geometric interpolation. I have done fundamental work on such geometric expansions of general relativity, both in the Newton-Cartan and in the opposite Carroll limit, which similarly leads to solvable subsectors. In this project, I will develop an initial-value formulation for the resulting actions and I will show that the associated initial-value problem is well-posed, opening a path to numerical simulations. Using similar limits in string theory, I will establish new solvable sectors of string theory on negatively curved spacetime that are relevant to top-down models of the holographic correspondence. On the other hand, in the astrophysically relevant setting of approximately flat spacetime, holography is much less understood, in part because of the null structure on its boundary. The supervisor (Prof. Marios Petropoulos) and myself have developed complementary approaches to constructing Carroll field theories on such null boundaries. Building on this, I will construct concrete dual field theory models, which will allow me to make contact with the celestial holography program of which Prof. Puhm is a world expert. The Centre de Physique Théorique at École Polytechnique is therefore the perfect place for me to unify these approaches to flat space holography and to work towards explicit constructions of top-down string theory models.

Mots clés : non relativistic gravity, string theory, holography, non lorentzian geometry, newton cartan geometry, carroll geometry, ads cft, flat space holography, celestial holography

Participants :
- École polytechnique (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €