Projet TREATMENT (Horizon 2020, appel à projets 2016)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

TREATMENT is a Marie Sklodowska Curie Innovative Training Network proposal directly addressing the need for high-level training and career paths in risk evaluation of drug induced metabolic dysfunctions, a relevant aspect, so far unexplored by traditional toxicology studies, but urgently needed to challenge current severe limitations of health care interventions in mental disorders. These patients require life-long medications that subsequently trigger metabolic diseases with a strong negative impact on their health and well-being. To achieve this, and improve adherence to treatments, we will evaluate how short-term antipsychotic drug responses impact long-term metabolic control to identify and validate biomarkers with clinically predictive value for targeting drug induced metabolic dysfunctions. This effort will have added commercial value by enabling the design of predictive marker kits for testing adverse secondary metabolic effects of drugs to be used in pharmacological and medical practice. TREATMENT will provide multidisciplinary knowledge, capabilities and tools to implement this ambitious strategy by the training of young scientists in a program that combines pharmacology, metabolism and mental health research with strategies for product and tool design and validation. Our ultimate goal is to empower the intersectorial and trans-national employability of young scientists across academic, public and private sectors to foster the development and implementation of personalized medicine tools that will provide effective treatment regimens for life long health-care interventions and decrease the risk for development of chronic metabolic diseases.

Mots clés : metabolism, adverse side effects, schizophrenia, life long treatment, personalized medicine, healthy aging, training, network, open science, horizon 2020

Participants :
- Cell Stress Discoveries (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 265674.6 €
- Comunidad de Madrid (Espagne) — Partner, beneficiary, Recherche, subvention : 247872.96 €
- Nimgenetics, genomica y medicina s.l. (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 247872.96 €
- Anaxomics (Spain) (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Uppsala University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 527318.64 €
- University of Lleida (Espagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Biomedical Research Networking Center on Neurodegenerative Diseases (Espagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- University of Ljubljana (Slovénie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 234997.56 €
- University of Coimbra (Portugal) — Partner, beneficiary, Recherche, subvention : 476712.72 €
- Bnml behavioral & molecular lab (Portugal) — Partner, beneficiary, Autres, subvention : 238356.36 €
- Hebrew University of Jerusalem (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 520601.04 €
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 991491.84 €