Projet INNOVATION (Horizon Europe, appel à projets 2022)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Erythrocytes represent an estimated 84% of all cells in the human body. During circulation, they experience a huge variety of physical and chemical stimulations, such as pressure, shear stress, hormones or osmolarity changes. These signals are translated into cellular responses through ion channels that modulate erythrocyte function. Ion channels in erythrocytes have only recently been recognised as the utmost important players in physiology and pathophysiology. Despite this awareness, their signalling, interactions and concerted regulation, such as the generation and effects of 'pseudo action potentials', remain elusive. INNOVATION proposes a systematic, conjoined approach using molecular biology, in vitro erythropoiesis, state-of-the-art electrophysiological techniques, methods to detect erythrocyte functionality and patient samples (channelopathies and other red blood cell-related diseases) to decipher and make use of ion channel functions in terms of disease treatment concepts. We need to overcome the challenges that hinder the gain of knowledge within the field, using genetic manipulation of progenitors, cell differentiation into erythrocytes, statistically efficient electrophysiological recordings of ion channel activity that are limited by the heterogeneity of the cell population (120 days of lifespan without any protein renewal) or access to large cohorts of patients. Our multidisciplinary team includes biophysicists and cell biologists to investigate erythrocyte characteristics and bioengineers to develop diagnostic devices. INNOVATION involves academic research centres as well as diagnostic labs providing patient samples, blood bank research centres developing cultured transfusion products and SMEs that provide and develop diagnostic tools or innovative therapeutic red blood cell products. The consortium offers on-site training, secondments and a variety of courses in transferrable and complementary skills to 10 doctoral candidates.

Mots clés : red blood cell, proerythroblasts, erythropoiesis, ion channel, membrane potential, channelopathies, channelrhodopsin

Participants :
- Lyon-I université (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 282693.6 €
- University Medical Center Utrecht (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Sanquin (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 548740.8 €
- European Research and Project Office (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- R&r mechatronics international bv (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 274370.4 €
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Partner, beneficiary, Autres, subvention : 259437.6 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de la Sarre (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 521078.4 €
- Cysmic gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 282693.6 €
- Sorbonne Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Infineon Technologies (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €