Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet 2D-NanoHyb (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Interfacing the solid-state electronics with biological systems has been a long-standing challenge in nanobiotechnology. Creating nanobio hybrids would enable harnessing the remarkable capabilities offered by solid-state materials and biological molecules, such as proteins, enzymes, DNA etc., at the same time. Two-dimensional (2D) materials are among the most prospective building blocks for future-generation electronic and biosensing devices due to their exceptional optoelectronic and mechanical properties combined with their atomic thickness. Their ultimate thinness has been considered as a remarkable advantage for nanopore-based sensing, and they have been widely investigated as 2D solid-state nanopore platforms for single-molecule sensing. The goal of this proposal is to push further the development of 2D nanopores by developing new protocols for creating interfaces between 2D materials and biomolecular motors. Attaching the enzyme motor, such as DNA helicase, to a nanopore made in 2D material would introduce an active control in nanofluidic transport of single-molecules and ions. Such hybrid platforms presents a step forward in uniting biological inspiration and nanoscale engineering, offering unprecedented levels of control, precision, and versatility at the nanoscale. The future direction holds promise across a wide spectrum of applications, from fundamental scientific research to transformative technologies that could impact fields as diverse as nanobiotechnology, personalized medicine and diagnostics, environmental sensing, nanorobotics, and many more.

Mots clés : nanopore sensing, 2d materials, nanobiotechnology, hybrid materials, molecular motors, functionalization, solid state nanopores, sequencing

Participants :
- Institute of Physics (Croatie) — Coordinator, beneficiary, Recherche, subvention : 146049.6 €
- École polytechnique fédérale de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet TissueEng (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Bone tissue engineering has been considered a viable solution Bone tissue engineering has been considered a viable solution for clinical restoration and recovery of defected bone tissue caused by injuries, skeletal dysfunction, and cancer. But current approaches are limited in developing cellular disease models to screen the target genes in tumour relapsing, which enables finding suitable preclinical strategies (animal model). The project will use 3D bioprinting to create an external field driving biosensor-impregnated 3D construct as a potential therapeutic platform for screening bone tumour behaviours and multidisciplinary approaches to bone defect recovery. Hence, the main objective is to determine if the formulation of chiro-magnetic nano-assembly incorporated electro-conductive hydrogel will be able to mimic the in vivo disease model to identify the target of expression in the osteosarcoma model, which will enable the finding of an effective therapeutic strategy for osteosarcoma treatment with gender diversity. The project will focus on the multidisciplinary approach (material science, biochemistry, and cell biology) in the formulation of the multifunctional 3D bioprinting hydrogel (visible light based photo-cross-linkable). The 3D construct will have tunable physical properties such as mechanical stability, chiro-magnetic, etc in determining all stages of cellular behaviour; magnetothermal activity in killing tumour cells; and electro-stimulation mediated osteointegration in tissue regeneration. The project will include the transfer of the candidate’s knowledge to the host and acquiring extensive training from UAveiro on advanced tools and techniques as a part of the career development plan. The results will have a potential impact on humankind and patients from all socio-economical levels, and they are in line with the EU mission to have a significant economic impact on the sustainability of public healthcare care for low-to medium-earning patients' families.

Mots clés : injectable hydrogel, chiromagnetic nanoparticle, spheroids, tissue regeneration, hyperthermia, osteoinduction

Participants :
- Université du Michigan (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Aveiro (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
Projet Eco-Mortar 2.0 (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

One of the priorities of the 2030 Agenda is to achieve a sustainable development path to balance environmental, social and economic needs for present and future generations. The United Nations Sustainable Development Goals (SDGs) are the blueprint to achieve a better and more sustainable future. The Green Deal is the roadmap towards the application of the 2030 Agenda and the SDGs in all European policies. In this context, the European construction industry faces great challenges that need real solutions. On the environment side, it is clearly a sector with an unsustainable environmental profile that will need to overcome the traditional linear path of production and consumption to adopt a Circular Economy model and Energy Efficient solutions. The number of studies on new sustainable solutions to minimize the incorporation of processed raw materials or improve thermal insulation properties of mortar have increased. Examples relate to the use of stone sludge waste from the cutting process as filler in rendering mortars or fibres from textile waste to reduce its cracking or to the increased insulation of rendering mortars through the incorporation of cork (recycled by-product of the cork industry) or silica-based aerogels (nano-structured material) as lightweight aggregates. However, studies focused on combination stone sludge waste, textile waste, recycled cork together with aerogel in mortars have not been found in the current literature. The main objective of the Eco-Mortar 2.0 project is to develop an eco-friendly and high-performance thermal insulating fibre reinforced rendering mortar for wall exterior retrofitting or wall panels coating of buildings by using diabase sludge from stone cutting as filler, recycled cork and aerogel granules as lightweight aggregates and textile waste as fibres. This mortar will decrease the use of non-renewable natural resources, improve thermal insulation and allow shrinkage cracking control.

Mots clés : circular economy, energy efficient, environmental, durability, mortar, waste, nanotechnology, thermal insulation, high performance, filler, fibre, aggregate, diabase sludge, textile, cork, aerogel

Participants :
- Université de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 156778.56 €
Projet GLOBE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The exponential growth of e-commerce has intensified the environmental and operational challenges of last-mile delivery (LMD), contributing significantly to urban congestion, energy consumption, and CO2 emissions. In response, GLOBE introduces an innovative two-echelon location-routing model designed to optimize LMD through the integration of eco-conscious customer behavior and sustainable transportation modes. This novel approach addresses a critical gap in existing models by incorporating the diverse and dynamic behaviors of customers, such as their transport choices for retrieving parcels from intermediate hubs. GLOBE explores the interplay between customer environmental awareness, availability of green transportation options, and real-world constraints like distance and scheduling, thus providing a more granular understanding of LMD’s true environmental impact. I will develop a mathematical model that will optimize both the flow of parcels from warehouses to urban hubs using traditional and eco-friendly vehicles, followed by final delivery to customers through zero-emission transport options and the flow of customers’ collecting parcels from the intermediate hubs. To overcome the computational complexities of large-scale urban logistics, my approach will employ advanced heuristic and math/metaheuristic algorithms. Additionally, dynamic and scenario-based methods are deployed to manage the inherent uncertainties in demand, travel times, and customer availability. Furthermore, in collaboration with two leading delivery companies, the models will be validated in real-world settings, demonstrating the feasibility of sustainable LMD strategies. My outcomes will provide actionable insights into reducing emissions, improving operational efficiency, and enhancing urban sustainability. In conclusion, GLOBE offers a transformative approach to last-mile logistics, paving the way for greener cities and more responsible consumer behavior.

Mots clés : last mile delivery, location routing problem, environmental impact, heuristic algorithms, uncertainty

Participants :
- Université de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191343.12 €
Projet NeuroblastORG (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Neuroblastoma (NB) is the most common cancer in infants and the 3rd most common cancer in children. According to the WHO 90% of NBs occur in children younger than 5 years old and 15% of all pediatric cancer related death are due to NB. Approximately 20% of NB cases are characterized by the amplification of the MYCN gene, which is linked to more aggressive tumors and poor prognosis (high-risk NB). Despite recent treatment advances, relapsing high-risk NB often leads to death. Understanding mechanisms of therapy resistance can help to develop more effective treatment protocols. However, investigation of acquired resistance upon chemotherapy is largely limited by the number of patients with high-risk NB and the availability of adequate model systems. Mice models of NB are often used, however species specific differences in sympathoblast development might result in misleading findings. Sympathoblast are the fetal counterparts of NB cancer cells and they are derived from the neural crest (NC). The overall aim of the NeuroblastORG project is to establish a human organoid model of the NC lineage, which can recapitulate human specific embryonic developmental stages, while also giving rise to sympathoblast-like NB cells, in addition to healthy sympathoadrenergic lineage derivatives (NB organoid). To reach this aim, human induced pluripotent stem cell lines will be genetically modified to overexpress the MYCN gene under the control of an NC-specific promoter, but only in a subset of NC cells within the organoids. Relevance of the established model will be validated by comparing gene expression signatures between NB organoids and human NB patient tumour samples. The NB organoid model system will provide a platform to simulate treatment of NB cells with NB-therapy relevant agents and monitor the effect of the applied treatment, allowing the investigation of human NB-specific chemoresistance acquisition in MYCN amplification related high-risk cases.

Mots clés : organoids, neuroblastoma, disease modeling, drug resistance, genome editing

Participants :
- Centre de recherche ensciences naturelles (Hongrie) — Coordinator, beneficiary, Autres, subvention : 157622.4 €
Projet SenseDiabetes (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

We are facing a global epidemic of type 2 diabetes (T2D). Diabetic neuropathy (DN) is the most common complication of T2D affecting ~50% of patients with T2D. If not diagnosed early, DN may lead to further catastrophic complications. However, despite its potentially huge impact on patients’ quality of life, and burden imposed on healthcare systems, patients with T2D and practitioners are often unaware of the manifestations of DN. To make things worse, currently there are no approved treatments for DN. SenseDiabetes has several aims. First, we wish to increase our knowledge regarding the pathophysiology of DN, specifically assessing whether patients with T2D and DN have worse insulin resistance compared to patients with T2D without DN. While previous studies on DN have shown an effect of insulin resistance on DN, poor indexes of insulin resistance have been used. In SenseDiabetes we will use for the first time the gold standard method for the assessment of insulin resistance, i.e. the euglycemic insulin clamp. Second, we will assess the efficacy of two commonly used antidiabetic drugs in early DN. Patients with T2D and early signs of DN will be randomized to receive treatment for 9 months with either Semaglutide or Empagliflozin. The effects of these drugs on DN outcomes (small fiber density, cardiovascular autonomic function) and advanced glycation end-products will be assessed. Further, we will study with ex vivo experiments the effects of the two drugs of peripheral nerve density (obtained with skin biopsies), and in in vitro experiments we will study the exact mechanisms of action of Semaglutide on cultures of peripheral nerves. Along with the scientific part, SenseDiabetes has a dedicated WP to increase awareness of DN.SenseDiabetes may thus be pivotal for the development of new strategies to combat DN. Also, SenseDiabetes aims to promote awareness of DN and thus increase societal impact through early recognition of DN and prevention of further complications.

Mots clés : diabetic neuropathy, insulin resistance, glucagon like peptide 1 receptor agonists, corneal confocal microscopy, lens fluorescence biomicroscope

Participants :
- Université nationale et capodistrienne d'Athènes (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 153486.72 €
Projet CaMeRoofs (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

One of the most fascinating aspects of medieval churches are the complex wooden frames of the roofs and the ceilings or vaults that dominate the interior. Cataloguing Medieval Roofs (CaMeRoofs) provides a multidisciplinary research on the roofing systems (external roof; internal wooden supporting structure; ceilings and vaults) of churches built between the 5th and 15th centuries, with the goal of creating a digital geodatabase for the architectural-historical study, the history of restorations, the typological-structural classification, the cultural contextualization and the state of conservation of the roofs. This preliminary stage of the project will focus on a specific territory that has preserved several cases of original or, at least, largely intact medieval roofing systems, despite restorations or modifications: the hinterland of the Veneto region (North Italy). This area is unique in Italy for its peculiar position, because it has received diversified cultural influences through the centuries (from East to West up to Northern Europe), which favoured the creation of different types of structures. 12 major monuments will be analysed: in this way, it will be possible to have an exhaustive sampling of all types of roofing systems built between the Early Middle Ages and the Gothic era. CaMeRoofs has the ambition to be a pilot project in Italy: based on solid European research experiences in this field, the project aims at creating an advanced and generalized system for the study and cataloguing of medieval roofs that can be continuously implemented and which will benefit the documentation, conservation and management of medieval architectural heritage. In the long term, thanks to the collaboration of other researchers, it will be possible to use this geodatabase on a much larger scale to highlight diversity and aspects that unite, across space and time, geographically distant churches with the goal of creating a European corpus of medieval roofs.

Mots clés : barrel vaults builders construction materials and techniques cross vaults dendrochronology domes geodatabase medieval roofing systems wooden ceilings wooden trusses 3d laserscanner

Participants :
- Université de Chypre (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 148488.0 €
Projet NUCA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Experiences of childhood adversity are major risk factors for subsequent vulnerability to psychopathology. Although research suggests that specific brain regions are particularly sensitive to childhood adversity, the mechanisms that underlie these associations are yet to be elucidated and it is unclear how widespread connectivity networks contribute to this vulnerability phenotype. This project aims to determine the functional connectivity networks in the brain that bare the signatures of negative experiences and the neuroendocrine mechanisms that facilitate such alterations. To achieve this, we propose two studies utilizing data from the UK Biobank. Study 1 will investigate the resting state networks associated with early adversity. This study will benefit from the statistical advantages of "big data". It will be the first analysis of this magnitude looking at the interplay between early life events and neural networks. Study 2 will characterize the inter-individual variations in adversity-related functional changes, by addressing the moderating effects of glucocorticoid-related genetic variants that increase biological vulnerability. This study will contribute innovatively to the state-of-the-art in the emerging field of imaging genetics. This research uses advanced statistical strategies for neuroimaging analysis of an unprecedented number of scans and use of innovative analysis infrastructures under the FAIR principles. Furthermore, it is strongly multidisciplinary, involving a combination of psychological theory, neuropsychology, neuroimaging, machine learning and genetics. This action will involve end-users in all implementation stages, with the aim to engage the public in science education, raise awareness of stress-related consequences and the need for widespread access to mental health care. The proposal encompasses knowledge transfer to the host institution, as well as extensive hands-on training for the candidate supported by the expertise of the host.

Mots clés : childhood adversity chronic stress resting state functional connectivity networks big data polygenic risk scores genetic variants

Participants :
- Asociatia transylvanian institute of neuroscience (Roumanie) — Coordinator, beneficiary, Recherche, subvention : 149575.68 €
Projet ARTEMIDE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Bridge and civil infrastructures maintenance, inspection, and monitoring are essential to economics and public safety. Thousand kilometres of road bridges over 100 metres in length in the Trans-European Transport Network. Many of the bridges were built during the 1950s and are now nearing the end of their useful life, as recent tragical events showed. Over the last twenty years, a large amount of research has been funded by European Research Framework Programmes for investigating materials, components, and software tools. However, in Horizon 2023 FP the focus has been already pointed to visual inspection techniques. With this perspective, ARTEMIDE points to create two fundamental methods to develop an innovative approach for the full-field identification of fatigue damage in outdoor-space structures, based on infrared imaging. The first method consists of a self-calibration and motion compensation tool for image conditioning, while the second method allows thermal measurements to be performed consistently and reliably in outdoor environments. In this way, damage assessment can be performed more efficiently and effectively than is possible today. The research will be developed at the University of Ljubljana, while three months are planned as secondment in DRI Investment Management Ltd., the largest consulting and engineering company in Slovenia. In the long term, ARTEMIDE will be fundamental for reaching a relevant academic position in Europe, with an eye to industrial collaborations with economics and social impacts.


Participants :
- Ddc svetovanje inzeniring, druzba za svetovanje in inzeniring, doo (Slovénie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Ljubljana (Slovénie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 155559.36 €
Projet HubCities (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Airport and seaport territories are special types of areas. They are hubs, centers of transport or transshipment activities, and centers of territories and networks that consume resources (land, water, and air). In Europe, there are 347 airports and 3,024 seaports. The challenges they face are at the heart of the EU’s policy frame of reference—confirmed, for example, by the Driving Urban Transitions partnership, which guides much-needed urban change toward a sustainable future. These challenges are addressed by a novel approach. The main aim of the project is to train a new profile of urban planner that is able to use citizen science in such difficult urban planning situations. Engaging residents in co-design, citizen participation, and citizen science is a bottom-up approach that is still underused. In applying a bottom-up approach, any further spatial development of these territories would include the perspectives of their inhabitants. Thus, an important step would be taken toward a long-term spatial future strategy. To be better understood, these territories need to be named as HubCities and decoded as an urban resource. Three supporting instruments will make it possible to develop a methodology: HubCities platform (as a communication instrument), HubCities labs (as an event engaging citizens), and HubCities toolkit (as a planning tool for citizens). The paradigm shift caused by such an approach would be applicable in practice, research, and education. Three selected HubCity regions will serve as a testbed: the airport and logistics center of Graz (Austria), networked passenger airport at the Koper seaport (Slovenia), regional passenger airport of Trieste port city (Italy). As a result of the project, my career prospects as a researcher will grow decisively: I will become the leading figure in adapting urban planning procedures with citizen science, approached by colleagues and actors for transfer of the skills acquired and high-quality planning solutions.

Mots clés : citizen science, airport and seaport territory, hubcities, urban resources, urban development, spatial sustainability

Participants :
- Université de Ljubljana (Slovénie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171399.36 €