Projet PRAETORIAN (Horizon Europe, appel à projets 2022)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Sepsis remains one of the major challenges for societies worldwide, causing an estimated 7-9 million deaths every year. It is the leading cause of death at intensive care units in the EU. This high mortality persists because at present methods for timely diagnosis are lacking and no effective therapy is available. Therefore, there is a clear and urgent medical need to provide novel diagnostics and therapeutics for use in sepsis. The PRAETORIAN Doctoral Network has created a doctorate programme to deliver innovative training on preclinical and clinical science, business- and entrepreneurial aspects, intellectual properties and more, covering multiple aspects of the drug discovery and development process. This programme is unique as it will deliver a new generation of young scientists, each Doctoral Candidates (DCs), who will collaboratively work to develop novel approaches in precision sepsis patient care providing new diagnostics and therapeutics to answer to an urgent unmet clinical need. Recent insights have indicated a pivotal role for neutrophil activation and so-called damage associated patterns in the initiation and propagation of sepsis. However a comprehensive view on how these processes cause the onset of sepsis remains elusive and there is an urgent need to translate experimental findings into adequate diagnostic and therapeutic solutions. PRAETORIAN was designed to address this urgent need by bringing together specialists from academia and industry to shape a new generation of entrepreneurial scientists who have skills, expertise and knowhow to further our understanding of sepsis pathophysiology into tangible and effective solutions for novel diagnosis and therapy.

Mots clés : sepsis, septic shock, organ failure, netosis, neutrophil activation, damps, clinical diagnosis, theranostics, precision medicine

Participants :
- Université Paris Cité (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 565387.2 €
- Stichting family and patient centered intensive care (fcic) (Pays-Bas) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- BerGenBio (Norway) (Norvège) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- 5-diagnostics ltd (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Deutsche sepsis-gesellschaft e.v. (Allemagne) — Partner, associated partner, Autres, subvention : 0.0 €
- France sepsis association (France) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université de Maastricht (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 548740.8 €
- Maastricht health campus bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Double green pharma (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Pepscan (Netherlands) (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Partner, beneficiary, Recherche, subvention : 503942.4 €
- Université d'Uppsala (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 587419.2 €
- Nsbm (Pays-Bas) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Münster (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 521078.4 €
- Basic pharma technologies b.v. (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Pharmatarget bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Hôpital Érasme (Belgique) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Sepsisföreningen (Suède) — Partner, associated partner, Autres, subvention : 0.0 €