Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet NAVSCHEN (Horizon 2020, appel à projets 2020)
Action : MSCA other
Statut du projet : CLOSED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Mots clés : chronic fatigue syndrome  cfs, myalgic encephalomyelitis  me, mobility and paralysis periods, enhancing items, palliative therapies

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 9643.75 €
Projet SNLS DARE EDF (Horizon 2020, appel à projets 2020)
Action : MSCA other
Statut du projet : CLOSED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Mots clés : snls

Participants :
- European Disability Forum (Belgique) — Coordinator, beneficiary, Autres, subvention : 10863.75 €
Projet VAPP (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The VAPP Project will examine prehistoric human population dynamics and microevolution in Portugal through the analysis of dental morphological variation. Variation in external dental morphology (e.g., size, shape, and discrete characteristics) provides reliable data on biological affinity and relatedness within and between human populations, as well as signatures of selection on dental functional morphology related to different diets and masticatory regimes. Advances in non-invasive, virtual imaging technology provide complimentary, high-resolution data on internal dental morphology (e.g., enamel thickness, tissue proportions, enamel dentin junction shape) that address key aspects of dental morphological variation and evolution. Nevertheless, few studies have focused on how internal dental morphology varies among human populations during the Holocene, and only one Homo sapiens dentition from Portugal has been virtually analyzed to date. The prehistory of Late Pleistocene to Mid-Holocene Portugal is characterized by complex environmental, climatic, and demographic changes that significantly altered socioeconomic organization, thus making it an ideal regional case study to address human biocultural evolution through an integrated approach to internal and external dental morphology. The VAPP Project will include Upper Paleolithic humans, the last foraging populations (Mesolithic), early food-producing peoples (Neolithic), and groups associated with the emergence of social complexity and the intensification of food processing (Late Neolithic, Chalcolithic, and Bronze Age). The sampling strategy provides a nuanced perspective on dental microevolution corresponding to changing diets, socioeconomic strategies, and spatiotemporal population dynamics (e.g., migration, integration, and replacement) across crucial transitional periods in Portuguese prehistory. Notably, the VAPP Project will establish the first, open-source, virtual dental anthropology dataset for the region.

Mots clés : bioarchaeology, dental anthropology, virtual anthropology, microcomputed tomography, paleolithic, mesolithic, neolithic, bronze age, microevolution, biocultural evolution, foraging, food production

Participants :
- University of Coimbra (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 147815.04 €
Projet EinsteinVRH (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

The Variable Range Hopping is considered in the Physics literature as an effective model for the analysis of conductivity in semiconductors. Understanding how the macroscopic parameters depend on the small-scale randomness of the environment and proving the Einstein Relation for this model is the ambitious aim of this project. Main objectives: 1) Extend recent results (law of large numbers, existence of a stationary state) for long-range reversible random walks on point processes including the possibility of traps. 2) Analyze how an external field influences the limiting velocity of the Variable Range Hop- ping, in comparison to similar models from Mathematical Physics. 3) Establish the first rigorous Einstein Relation for a physically relevant model, the Variable Range Hopping. The mathematical techniques we have at our disposal nowadays (such as the weak Einstein Relation and the control of long range models) are a solid basis for the investigation of the problem: This would be the first time an Einstein Relation is rigorously proven for a relevant physical model. Furthermore, the richness of the subject guarantees also many intermediate results of great relevance in the field of Probability Theory. Besides the big scientific relevance of the expected results, the project will have a strong impact also on the career of the experienced researcher, completing his international profile of independent scientist, and will also strengthen the interplay between the Probability Theory communities of France, Germany and Italy. Finally, a positive outcome of the action will bring a significant insight on the physical study of semiconductors.

Mots clés : random walks in random environment, einstein relation

Participants :
- Université Paris Dauphine - PSL (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173076.0 €
Projet WINNINGNormandy (Horizon 2020, appel à projets 2020)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

The WINNINGNormandy Fellowship Programme will foster the research excellence and innovation activities, and increase the international attractivity and influence of the Normandy Region in France by recruiting 40 two-year postdoctoral fellowships in two calls. The choice of the host institution and the research topic in the frame of the 6 areas of smart specialization is entirely left to the experienced researchers based on individual-driven international mobility. The consortium gathers the leading interdisciplinary higher education institutes, exceptional research organizations and large infrastructures in the region, as well as over 20 industrial partners (large groups, SMEs, start-ups) operating in the areas of specialization. They will strongly contribute to the implementation of the programme by hosting research fellows, providing secondments and/or specific training, intersectoral mentoring, networking and business opportunities. Several actors in human resources, project management, entrepreneurship and outreach complete the partnership to drive together the specifically tailored transferable skills training program, personalized career development, and encourage results exploitation and large diffusion. This ambitious educational and research programme will structure and implement the HRS4R principles for the postdoctoral level recruitment, working and living conditions, training and career management in the region, as well as contribute to sustaining and developing industrial activity in Normandy, making the green and energy transition a success and improving the well-being of citizens and the resilience of the territory.

Mots clés : post doctoral research fellowships, normandy region, international, intersectoral, interdisciplinary training, smart specialization, transferable skills

Participants :
- Conseil régional de Normandie (France) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 2942400.0 €
Projet skILL (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The adjuvant potential of bacterial lipopolysaccharide (LPS) for vaccines depends on a detailed understanding of its innate immune signalling properties, in order to achieve the right balance between immunogenicity and reactogenicity. By biosynthetic engineering of meningococcal LPS, we have obtained a unique panel of mutants covering a wide range of endotoxic activity, from the maximum wildtype level to almost totally inactive. However, this is based on activation of the TLR4/MD-2 receptor, and recent studies have revealed that LPS endotoxic activity is also mediated by the intracellular receptor caspase 4 (caspase 11 in the mouse). At present, it is not clear how this contributes to the overall biological activity of LPS, and how it can be modified by structural alterations to the lipid A moiety of LPS. A major contribution of the proposed project will be to provide for the first time a detailed structure-function relationship for this LPS-caspase 4/11 interaction. This information will be crucial in the further evaluation of the adjuvant potential of these LPS derivatives, as well as giving more insight in the role of LPS modification in the interaction of pathogenic bacteria with the innate immune system. LPS mutants with differential effects on the TLR4 and caspase pathways will provide a unique opportunity to tease apart the contributions of both pathways to the overall LPS biological activity. In addition, we will explore the role of delivery of LPS by OMVs (outer membrane vesicles) to the intracellular pathway activation. A second and complementary contribution will be the development of novel LPS purification methods, which will also lead to better understanding of LPS structure-function relationships by allowing the separation of complicated LPS mixtures in their individual molecular species. In addition, they will pave the way for purification procedures which can be upscaled for making clinical grade LPS in human vaccine applications.

Mots clés : vaccine, bacterial outer membrane, lipopolysaccharide, adjuvant, innate immunity, immune signalling, neisseria meningitidis

Participants :
- Ministry of Health Welfare and Sport (Pays-Bas) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 177598.8 €
Projet GenDels (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The advent of the revolutionary genome editing technique CRISPR-Cas9 has enabled targeted gene mutation, repression, and activation, facilitating impactful biological findings. However, Cas9 as an unbiased DNA deletion tool is limited in its ability to interrogate large regions of DNA of unknown function, because it predominantly generates very small (<20 bp) insertions and deletions at its target site. The capacity to rapidly and efficiently generate large genomic deletions does not currently exist and would be an extremely useful tool for research, allowing for rapid strain engineering of bacterial cells for synthetic biological and metabolic engineering purposes. Additionally, this technology would allow for the interrogation of large segments of non-coding DNA in human cells, much of which has unknown function, but whose variants are often associated with human disease. In this proposal, I aim to develop a Type I-C CRISPR-Cas system employing the Cas3 enzyme (completely distinct from Cas9), which naturally possess coupled nuclease and helicase activity, for high-throughput gene-editing purposes in various prokaryotic, as well as human cells. My preliminary results have shown that this is a credible approach, as I have been able to generate individually, as well as in combination, multiple deletions in bacterial organisms exceeding 60 kb in size. A focal point of the proposal is to adapt this system for use in human cells, which would provide a novel basic research tool with unprecedented capabilities and also could be utilized in human health-related applications. The proposal aims to address this later possibility by utilizing the developed system to treat human cell lines infected with difficult-to-treat pathogenic viruses.

Mots clés : crispr cas3, genetic engineering, viral defense

Participants :
- European Molecular Biology Laboratory (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 264669.12 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet V.I.P. (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The aim of the proposed V.I.P. project is to achieve passive localization and posture identification of multiple humans in indoor environment for assisted-living functionalities. We propose to use the temporal-spatial-delay domain radio channel properties with dedicated design of massive Multiple-Input Multiple-Output (MIMO) topology and configuration for specific physical environment, and use the neural-networks-based learning algorithm recognizing the interactions between the human form-factors (body type/shape, posture, motion) and the aforementioned indoor radio channel. Both simulation and measurement platforms will be built to estimate and measure the radio propagation resulting from the reconfigurable physical environment, multiple-antenna systems, and human form-factors. The proposed research is multidisciplinary, connecting networked systems, electromagnetism, smart building, human factors, and data science. It proactively combines MIMO radio networked system with smart building, targeting at identifying MULTIPLE humans with the help of neural networks. It is proposed by a female researcher with rich international experience, and is supervised by a female professor with top track record. The proposed research includes gender-dependent modelling and parameterization on the propagation mechanism of human-radio interaction, potentially using the double-layer reflection and the uniform theory of diffraction. The body postures are simplified into geometries with homogeneous dielectric, e.g. a standing/laying human as ellipsoid, sitting on the ground with legs crossed as triangle. Upon the completion of the research, training and networking of V.I.P., the researcher will profit from the first-hand experience on designing and developing the networked system for specific use case, developing neural-network-based pattern recognition methodology, as well as growing towards professional maturity from proposing, coordinating, finance managing, educating to impacting.

Mots clés : distributed  massive  mimo, networked system, antennas and radio wave propagation, indoor, passive localization and posture identification, radio body interaction, multiple humans, machine learning

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166320.0 €
Projet EVIDENCITY (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of this architectural research is to analyses material transformations of Sarajevo—the destruction and reconstruction caused by the war (1992-1996), from documents (videos, photos, and drawings) produced by citizens. Finding these documents is important in the shared process of collective memory creation by Bosnians, but also for academic research and post-war reconstructions. For EU citizens, understanding Sarajevo citizens’ experience can help them to understand the realities of life of the actual war contexts (i.e. Syria). As a citizen who experienced the war, an architect and a researcher of the war cities, my research objective is to expand architectural research methods by focusing on how war affects the transformation of cities through a process combining architecture and media research. I will apply interdisciplinary research methods used in architecture/planning (i.e. geographic information system - GIS), media studies (i.e. video) and anthropology (i.e. interviews). To use media tools is a complement to architect research and representation (i.e. video) modes because they create documents (i.e. drawings) understandable only to architects. Research will be accessible to scientific and general public through a web platform, called Evidencity, which will include map-based, multimedia research archive. Regarding to my academic career this project contributes: obtaining academic profile in the fields of architectural research methods and media for researching of different war cities; advancing my skills as an architect (i.e. analysis of the destroyed city) for working on projects related to the post-war reconstruction. The European continent is constantly dealing with states of war, on its territories (Ukraine) or on its borders (Libya-Italy). Proposal aims to contribute using research results to create interdisciplinary guidelines for architectural research to the emerging field of urban conflict studies that will be applicable to the other war cities.

Mots clés : documenting of the war, architecture and media, war material transformations, research methods

Participants :
- Delft University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet APTALAPS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The aim of this project is to develop a new method to immobilize aptamers of stem cells onto silicon-on-sapphire substrates, to capture cells by affinity interaction between aptamer and target cells, and investigate two-dimensional electrochemical images of parameters such as local cell impedance, cell surface charge, ion channel activity, and two-photon fluorescence images with subcellular resolution using the impedance imaging technique Scanning Photo-induced Impedance Microscopy and the electrical potential imaging technique Light-Addressable Potentiometric Sensors. Aptamers are artificial functional oligonucleic acids which can bind their targets with high affinity and specificity. Aptamers with specificity to target integrin heterodimers will be developed and patterned on LAPS substrates and the mechanism of attachment regulated stem cell differentiation studied. The proposed technique has the advantage that functional electrochemical imaging of the cell-surface interface can be carried out, which is not accessible to other electrochemical techniques. The results of the project will inform the development of tissue engineering materials and impact on the health care and biomaterials industries, which are central to Europe's ongoing and future economic success, and are directly relevant to the theme priority of personalizing health and care in Horizon 2020. The applicant is an outstanding young scientist who recently finished his PhD at Peking University and has already authored and co-authored 14 papers, worked on different multidisciplinary projects in China and Japan, and brings a lot of relevant experience to the project in the areas of aptamers, electrochemistry, and biosensors. During the fellowship, he would develop competencies in electrochemical imaging, semiconductor processing and single cell analysis, expand his research network and gain skills such as project management and grant writing allowing him to develop an independent research career.

Mots clés : light addressable potentiometric sensors, aptamer, mesenchymal stem cell, cell surface interactions

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet TimeAdapt (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The aim of this proposal is to develop statistical methods for inference of demography and adaptation from genetic data collected at several times along the history of the population. In particular, I will target genomic data obtained from human remains from archaeological sites of hunter-gatherers, early farmers and Pontic-steppe herder groups and current European populations. The originality of my proposal is to address the the joint inference of neutral and selective forces acting on populations. In order to achieve this, I will take advantage of recent advances (the use of random forests in approximate Bayesian computation) that alleviate the computational burden of these inferences. The methods developed will be relevant to the community of evolutionary biologists in general and for human evolutionary biologist and archaeologists. The results will further clarify the genetics of the Neolithic transition in Europe, particularly regarding the role of adaptation and admixture. These results will be disseminated to the scientific community in the standard way (conferences, peer-reviewed journals and software implementing the methods) and to the general public through short animated films. The main training goal of the fellowship is to acquire experience in the analysis of high throughput sequencing data in a model organism (sensu lato), gaining international experience. This will increase my chances to lead research projects and further advance my career. The Jakobsson Lab will be the ideal place to achieve all these objectives because of its expertise in theoretical population genetics, human evolutionary biology and ancient DNA.


Participants :
- Uppsala University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185857.2 €
Projet DecodeRemapping (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The aim of this research is to understand space constancy, that is the mechanisms used by the brain to build a stable and continuous percept of our environment despite frequent movements of our sensory receptors (eyes, ears). For example, each time we move our eyes, the image of the outside world sweeps across the retina, yet we see the world as stable. Studies using single cell recording in animals have shown that some visual neurones predict what the world will look like after an eye movement by remapping their receptive fields to the place they will occupy following the movement. In my previous studies I developed behavioural tools that allowed me to model remapping in human as an attentional process. Even though my findings in humans were largely consistent with the results obtained from single cell recordings in animals, there was no possible way to establish a direct link between these data. Recent methodological advances in functional imaging, both in terms of techniques and data analysis make this possible. By combining my tools with novel imaging analysis of human population receptive fields, I aim to determine the mechanisms our brains use to stabilise our percept of the world for visual and auditory objects. Using hemodynamic (fMRI) and behavioural (gaze recording) signals I will decode the organisation of the multi-sensory spatial maps. I aim to determine the role of attention for space constancy, to establish innovative methods and procedures for investigating human spatial cognition, and to reconcile human and animal neurosciences findings by providing precise neural information of the maps and the neural mechanisms of human spatial navigation. This interdisciplinary project will constitute a unique opportunity to combine my expertise with state-of-the-art methods. I will have the chance to expend my skills, putting me on the best track to pursue a future independent research career with a multi-faceted profile of psychologist and neuroscientist.

Mots clés : remapping, space constancy, attention, population receptive field, decoding, fmri, multi sensory stimulation, human superior colliculus

Participants :
- Vrije Universiteit Amsterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €