Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet STARFLOOD (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Floods are among the costliest of all natural hazards. The June 2013 flood in Central Europe, for example, incurred more than EUR 12 billion of economic losses, and flood risks are expected to increase significantly in the future. Reliable approaches for estimating flood probabilities in space and time are needed for optimising flood risk management. For almost a century, the standard method of flood estimation has been the purely statistical “flood frequency analysis”. The method does not account for the spatio-temporal behaviour of floods which, however, is essential for trans-regional flood planning as stipulated in the EU Flood Directive (2007/60/EC). Also, flooding is a physical process in space and time, so future flood risk assessment requires a better understanding of the physical basis behind the space-time characteristics of flood probabilities. These have been explored only by a few studies, e.g. by coupling weather models with runoff models, but only at small spatial scales and ignoring the space-time characteristics of the weather fields, hydrological processes and flood peaks. My project “Space-Time scAling of the Rainfall to FLOOD transformation” (STARFLOOD) responds to this research gap by investigating, for the first time, how the probabilities of rainfall transform into probabilities of floods from a space-time perspective, and how they can be simulated by space-time stochastic weather models at large spatial scales. STARFLOOD is highly innovative as it (i) explores the performance of the full cascade of rainfall to flood probabilities, (ii) explores the physical causes of flood probabilities and (iii) significantly improves the understanding of the scaling behaviour of hydrological processes. STARFLOOD will become a pioneering framework for the improved implementation of the EU Flood Directive and thus significantly advance future trans-regional flood risk management across Europe.

Mots clés : hydrology, flood modelling, flood hazard, rainfall, scaling behaviour, weather generation

Participants :
- TU Wien (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166156.8 €
Projet RiceStyle (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Flowering plants (angiosperms) protect their female reproductive structure, the ovule, within a carpel. After the embryo sac in fertilized by the pollen tube, the ovule gradually turns into a seed, and the carpel becomes a fruit. The carpel is thus an evolutionary conserved structure, but showing an outstanding variability in shapes and function. Several transcription factors directing the main aspects of carpel formation and morphogenesis, are quite well characterized in the model eudicot plant Arabidopsis thaliana. More recent evo-devo studies suggest that some of these transcription factors are functionally, conserved, at least in eudicot plants. However, this knowledge is far to be complete, especially if we consider the basal angiosperm taxa and monocots. This proposal aims to investigate more in depth these phenomena, using as main model species rice (Oryza sativa), and subsequently to do comparative studies in other evolutionary significant species. The final goal is to achieve a broader knowledge about the transcriptional machinery ruling carpel development, and its degree of functional conservation among the most relevant angiosperm taxa, by means of innovative techniques. The proposal will also allow us to address new evidence about the molecular pathways acting downstream this transcriptional network. The proposal will have a significant impact in basic and future applied research, addressing the Horizon 2020 objective to invest in future jobs and strengthen EU position in research, innovation and technology, sustainable development climate change excellent science.

Mots clés : oryza sativa, angiosperms, evo devo, carpel, style, stigma, transcription factors

Participants :
- Shanghai Jiao Tong University (Chine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 223120.8 €
Projet HO2PF (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Flows of two immiscible fluids separated by an interface, referred to as "two-phase flows", are ubiquitous in nature and central to many engineering applications. They contribute to the underlying principles and processes of a vast range of key sectors such as energy, transportation, manufacturing, and healthcare, and are relevant to the study of climate-change and disease-spreading. Most important to Europe's current challenges, the study of two-phase flows is instrumental in achieving the "European Green Deal" objective of reaching carbon-neutrality by 2050. Yet, despite their clear significance, our understanding of two-phase flows remains limited. Recently, computer simulations have become viable alternatives to experiments for their study, but they are still limited in terms of their flexibility, efficiency, and accuracy. The research programme proposed for this fellowship will provide a paradigm shift in the way two-phase flows can be simulated and therefore studied, with the development of the first high-order numerical framework for the accurate solution of their evolution in complex three-dimensional flow domains. This will entail increasing the order of representation of the local numerical approximations of the interface between the two phases, from linear to quadratic. This enhancement will in turn allow the development of high-order numerical schemes for the transport of this interface, and the estimation of the surface-tension force acting on it. These highly accurate schemes will be released to the research community in an open-source library. Not only will this enable the design of the next generation of low-emission energy-conversion technologies, which are crucially needed to reach Europe's environmental targets, but this will also yield substantial advances in manufacturing and health-related applications and in the prediction of climate-change, and will help devising future environmental and public health policies.

Mots clés : two phase flow modelling, volume of fluid method, interface reconstruction, high order

Participants :
- Otto-von-Guericke University Magdeburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 246669.12 €
- Cornell University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet UniCHydro (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

Fluid dynamics is an effective description that applies to a variety of physical systems such as the quark-gluon plasma produced in heavy-ion collisions at RHIC and LHC. Recently, it has become of foremost importance to develop a hydrodynamic theory that incorporates the effects of statistical thermal fluctuations of the background. With such a framework at hand, it would be possible to analytically access many physical situations where statistical fluctuations are dominant such as in turbulent flows and, for example, around the putative critical point in the phase space of Quantum Chromodynamics (QCD) at finite temperature and finite baryon density. Another place where such considerations become relevant is in the physics of Quantum Chaos. Recent developments have shed new light into manifestations of many-body quantum chaos and have lead to the formulation of an effective theory for chaotic systems, albeit with a large number of degrees of freedom. Deviations from this limit seem to strongly indicate the necessity of including statistical fluctuations. Understanding these effects would help to classify the different universality classes of chaos to complete the survey of its manifestations. The research proposal “UniCHydro” addresses several strategic aspects mentioned above related to universal properties of fluid dynamics and quantum chaos. The Experienced Researcher is an expert on Schwinger-Keldysh effective field theory techniques which constitute the starting point for developing this research proposal. The stimulating environments of MIT and the University of Florence will allow then the Experienced Researcher to acquire the new set of skills in analyzing statistical fluctuations and new competencies in quantum chaos which will be fundamental to enhance its career prospects and to become a mature and independent scientist.

Mots clés : holography, cft correspondence, relativistic hydrodynamics, schwinger keldysh effective field theories, effective field theories, quantum chaos, heavy ion collisions, quark gluon plasma

Participants :
- Massachusetts Institute of Technology (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Florence (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269002.56 €
Projet ElectroCatFlow (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Fluorinated arenes are an invaluable class of organic compounds with important applications in pharmaceuticals, agrochemicals, and materials. Additionally, fluorine-18 has secured its place as the important radionuclide used in positron emission tomography (PET), largely due to attractive physical and nuclear characteristics. Through the years, use of transition-metal catalysis has revolutionised the access to these challenging compounds. However reliance on expensive catalysts and ligands, elevated temperatures, extended reaction times, and limited substrate scopes remain unsatisfied. This project untitled “Fluorination of Aryl Halide Compounds under Electrochemical-Flow Conditions” or “ElectroCatFlow” aims to develop a novel method to access aryl fluorides using a transition metal-catalysed fluorination reaction of aryl halides under electrochemical-flow conditions. ElectroCatFlow is highly interdisciplinary, involves mechanistic investigations, and applications of electrochemical-flow techniques to afford a mild, efficient and inexpensive method compared to current strategies. This project will generate broad interest from academia and industry, and will lead to high impact publications including scientific papers and potential patents. Finally, ElectroCatFLow will also maintain and improve European´s excellence in fluorination, catalysis and flow chemistry by creating a synergistic collaboration between the partner and institutions. Besides, this proposal aims to significantly influence on the EU healthcare system given the relevance of fluorine based drugs have in the Society.

Mots clés : fluorination, flow chemistry, electrochemistry, catalysis, mechanism, medicinal chemistry

Participants :
- Eindhoven University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 271052.16 €
- Scripps Research Institute (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ASYMFLU (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Fluorine is a key element in modern pharmaceutical, agrochemicals and anesthetics. It is well-known that fluorine substitution can strongly improve drug efficiency by modifying the properties of compounds such as lipophilicity, metabolic stability, bioavailability and protein binding affinity. The selective installation of fluorine into molecules, especially in a catalytic way, still represents a major challenge for organic synthesis. To date, chemists have developed a range of transformations for carbon-fluorine bond formation yet the vast majority employs fluorine sources derived from F2, a highly toxic and corrosive gas. Only few processes involve the use of cheaper fluoride salts but often require expensive transition metals and suffer from a limited scope. With this proposal, we envision the development of a novel asymmetric metal-free catalytic reaction for carbon-fluorine bond formation by employing cost effective fluoride salts. The organocatalytic process we have designed is mechanistically unprecedented and will be applied to the synthesis of enantiopure fluoroamines which have a direct application in medicinal chemistry. This novel methodology will therefore provide a novel toolbox of reactions for chemists both from academia and industry and has the potential to have a strong impact on society by improving diagnostics, patient care and health-related quality of life.

Mots clés : fluorination, organocatalysis, fluoride metals, fluoride salts, fluoroamines, positron emission tomography, radiolabelling

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet FlyHigh (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Environment and Geosciences
Statut du projet : CLOSED

FlyHigh studies underexplored phytophagous and saprophagous flies and geophyte plants aiming to obtaining ecological and evolutionary data that will be used to elucidate ecological features of fly species that could be exploited for artificial mass production of flies. Artificial mass rearing of flies produces beneficial end products, the flies themselves or their larval stages, that could be applied for different services in agriculture, ecological farming or as bio-agents for e.g. complementary pollination services in natural or greenhouse environments. The main aim is to facilitate cross-sectorial transfer of knowledge and training of researchers as well as technical staff in bridging the gap between scientific results and their application into novel business ideas. The excellence of the project lies in the synergy of basic and applied ecology for exploring and developing new protocols and end products. FlyHigh brings together experts with well documented scientific achievements of the focal organismal groups and on evolutionary analyses with early stage researchers with the same research focus, with experts on insect mass rearing techniques. The relevance of FlyHigh results from integration of project aims that may result in innovative results of broader impact that will benefit the ERA institutions as well as the TC partner. The results could be advantageous in developing new ideas for future use e.g. flies could complement or even replace the presently used managed pollinators in greenhouse productions of many greenhouse products. The obtained data will also allow us to estimate the possible biogeographic events that can help explain the evolutionary history, current distributions and future biogeographic patterns of some bulb plant and fly groups in South Africa and in Euro-Mediterranean region. The outlined training course, workshops and secondments ensure transfer of knowledge between participant academic and non-academic partners, in both directions.

Mots clés : phylogeography, evolutionary history, biodiversity, biotechnology, artificial rearings techniques, mini live stock

Participants :
- Bioflytech sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 112500.0 €
- University of Novi Sad (Serbie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 135000.0 €
- University of Alicante (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 126000.0 €
- University of Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 76500.0 €
- Agri protein technologies (pty) ltd (Afrique du Sud) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet RNF (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Focusing on neoliberalism's emergent feminist discourse in the UK and the US, I aim to provide a multi-dimensional theorization of this phenomenon. Two central questions inform this project: 1) Why does neoliberalism need feminism at this particular historical juncture in order to reinforce its hegemony? and 2) How and in what ways do certain themes of feminism lend themselves to the neoliberal project? Working on the seams of feminist theory, cultural studies and sociology, I will embark on a comparative study, examining one key but neglected site of neoliberalism's adoption of feminism: the discourse of a happy work-family balance. In order to accomplish this, I will employ a multidisciplinary methodological approach, combining textual and discourse analysis, qualitative data analysis and intersectional theorizing. My premise is that the resurgence of the work-family balance, which is being articulated as a feminist ideal, is the site through which the contemporary entanglement of feminism and neoliberalism is most clearly articulated. RNF therefore has four main interrelated objectives: to map the current resurgence of the work-family balance discourse in the mainstream print media in the UK and the US; to uncover the racial and economic underpinnings of this balance discourse; to analyse the new feminist subject this discourse is creating; and, finally, to build a theoretical framework that not only helps to explain why neoliberalism needs feminism at this historical juncture, but one that can help account for other contemporary alignments between feminism and neo-conservative and neoliberal projects in the broader European and Western context.

Mots clés : feminism, neoliberalism, new feminist subject, work family balance discourse, professional women

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet devUTRs (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Following fertilisation, metazoan embryos are transcriptionally silent, and embryogenesis is controlled by maternally deposited factors. Developmental progression requires the synthesis of new mRNAs and proteins in a coordinated fashion. Many posttranscriptional mechanisms regulate the fate of maternal mRNAs, but it is less understood how translational control shapes early embryogenesis. In eukaryotes, translation starts at the mRNA 5′ end, consisting of the 5′ cap and 5′ untranslated region (UTR). Protein synthesis is primarily regulated at the translation initiation step by elements within the 5′UTR. However, the role of 5′UTRs in regulating the dynamics of mRNA translation during vertebrate embryogenesis remains unexplored. For example, all vertebrate ribosomal protein (RP) mRNAs harbor a conserved terminal oligopyrimidine tract (TOP) in their 5′UTR. RP levels must be tightly controlled to ensure proper organismal development, but if and how the TOP motif mediates RP mRNA translational regulation during embryogenesis is unclear. Overall, we lack a systematic understanding of the regulatory information contained in 5′UTRs. In this work, I aim to uncover the 5′UTR in vivo rules for mRNA translational regulation during zebrafish embryogenesis. I propose to apply imaging and biochemical approaches to characterise the role of the TOP motif in RP mRNA translational regulation during embryogenesis and identify the trans-acting factor(s) that bind(s) to it (Aim 1). To systematically assess the contribution of 5′UTRs to mRNA translational regulation during zebrafish embryogenesis, I will couple a massively parallel reporter assay of 5′UTRs to polysome profiling (Aim 2). By integrating the translational behaviour of 5′UTR reporters throughout embryogenesis with sequence-based regression models, I anticipate to uncover novel cis-regulatory elements in 5′UTRs with developmental roles.

Mots clés : regulation of mrna translation, top motif, 5 utr, zebrafish embryogenesis, in vivo massively parallel reporter assay

Participants :
- University of Basel (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet ERNI2016 (Horizon 2020, appel à projets 2016)
Action : European Researchers' Night
Statut du projet : CLOSED

Following previous TEN years of successful implementation of European Researchers' Night in Israel we will have: o Venues covering the whole country. o Involvement of the academic community including Israel Ministry of Science, Technology and Space (MOST), all major research universities, leading collages and three science museums. o Awareness campaign at national level managed and funded by the Israel Ministry of Science, Technology and Space. o Groups of junior-high and high-school students (ages 12-18) will be invited by each partner to take part in each venue. We are ready and proud to implement European Researchers' Night 2016 & 2017. • All of the partners involved in the project have the experience of running successful European Researchers' Nights events. • With the successive increase in number of visitors along the years and the reputation of the event we are expecting more than 55,000 visitors each year. • Same management as in 2011, 2012, 2013, 2014, 2015 successful events. • Proposal covers both 2016 & 2017 European Researchers' Night events.

Mots clés : research, education, dissemination

Participants :
- Bar-Ilan University (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20210.0 €
- Reichman University (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 10230.0 €
- Israel Oceanographic and Limnological Research (Israël) — Partner, beneficiary, Recherche, subvention : 26904.0 €
- University of Haifa (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 26916.0 €
- Oranim Academic College of Education (Israël) — Partner, beneficiary, Autres, subvention : 10230.0 €
- Al-qasemi academy association (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 10230.0 €
- Open University of Israel (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20238.0 €
- Madatech (Israël) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 53718.0 €
- Hebrew University of Jerusalem (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20224.0 €
- Sami Shamoon College of Engineering (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20218.0 €
- Tel Aviv University (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20230.0 €
- Weizmann Institute of Science (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20218.0 €
- Bloomfield Science Museum Jerusalem (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20244.0 €
- Migal - Galilee Technology Center (Israël) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 20190.0 €