Projet PEARRL (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

The European Pharma industry is a major contributor to EU well-being, both in public health and economic (sales >200 billion €/year) terms. To maintain global leadership, it must respond to challenges from low-cost producers e.g. China by bringing new drug molecules to market in a streamlined, cost-effective manner. This strategy is underscored by recent initiatives of European regulators to expedite the approval of “breakthrough drugs” so patients can gain earlier access to life-saving drugs. To realise these goals, scientists with an integral understanding of drug development and regulatory approval processes are urgently needed. PEARRL will train 15 Early Stage Researchers (ESR) who can develop new bio-enabling formulations (“better drugs”), biorelevant and in silico methods to predict formulation performance in vivo (“streamlined development”) and serve as communication bridgers between research and regulatory science (“accelerated approval”), thus bringing Pharma and regulatory objectives to fruition. PEARRL brings a multi-sectorial team, comprising key European regulatory authorities, academic leaders in bio-enabling formulations and biopharmaceutics tools, and an array of Pharma companies with a wealth of combined experience in bringing molecules to market, together for the first time to deliver a unique research and training programme. Key PEARRL elements are individual research projects with synergistic output; exposure of all ESR to academia, industry and regulatory in secondments; and ongoing innovative learning via Online Portals, Science Slams and Boot Camps. Key PEARRL impacts will be availability of excellent pharmaceutical researchers; streamlined drug development with a higher success rate for the industrial partners; enriched academic research through cooperation with industry and regulatory; earlier availability of breakthrough medicines to patients; a competitive pharma industry in Europe and contributions to European public health interests.

Mots clés : pharmaceutics, drug development, pharmacokinetics, oral bioavailability, regulatory science, molecule to medicine, drug formulation, oral drug delivery, biorelevant testing

Participants :
- Goethe University Frankfurt (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 747649.44 €
- Pion inc.(uk) ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 273287.88 €
- Pharmaten anonymos viomichaniki kai emporiki etaireia pharmakeftikon kai kallyntikon proionton (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 242386.92 €
- University of Bath (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 546575.76 €
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 531349.2 €
- Merck (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- University of Applied Sciences and Arts Northwestern Switzerland (Suisse) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 530453.52 €
- National and Kapodistrian University of Athens (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 484773.84 €
- Lundbeck (Denmark) (Danemark) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Janssen (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 250560.0 €