Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet LANTERN (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Our understanding of the first billion years of the Universe, specifically the initial 500 million years, remains quite limited. Until last year (prior to the James Webb Space Telescope launch), only one galaxy had been detected during this period. Since then, the number of candidates from these epochs has surged. This newfound abundance of candidates offers an unprecedented opportunity to delve into a crucial phase known as the epoch of reionization (EoR) marking the Universe's last major gas-phase transition in cosmic history when all the neutral hydrogen gas between galaxies produced by the Big Bang became fully ionized. The actors of this transitional period, the mechanisms underlying its emergence, and the physical properties of galaxies during this period are still mainly unknown. Thus, my research aims to probe the fundamental physics governing these galaxies (particularly their density, luminosity, and stellar mass) and investigate if these properties align with our theoretical framework and hydrodynamic simulations. Preliminary studies, including mine, indicate an excess of bright galaxies compared to the models. I aim to unambiguously quantify the excess of bright galaxies during the EoR, characterize their properties, and investigate the underlying physical phenomena that have driven these galaxies to acquire such properties. In particular, I aim to unveil the emergence of dust during the EoR. The core of this research revolves around leveraging the complementarity between the JWST through the COSMOS-Web program – the largest JWST program designed for detecting these galaxies and for which I am one of the architects - and the Euclid telescope.  The outstanding research environment at AIM (host institute) along with my supervisor's expertise offer optimal conditions to enhance my career prospects. Returning to Europe and elevating my profile on national and European platforms through this fellowship align seamlessly with my career's natural progression.

Mots clés : high redshift galaxies, epoch of reionization, jwst, uv luminosity function

Participants :
- Commissariat à l’énergie atomique et aux énergies alternatives (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet EVIDENTIAL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The EVIDENTIAL project (rEVealIng Drug Effects when applyiNg psychomeTrics In schizophreniA triaLs) seeks to enhance the accuracy of treatment outcome measurements in schizophrenia clinical trials by refining existing gold standard assessment tools such as the Positive and Negative Syndrome Scale (PANSS) and Brief Psychiatric Rating Scale (BPRS). These tools have limitations in accurately measuring treatment efficacy. The project aims to address this by applying advanced psychometric methods, including Factor Analysis (FA), Item Response Theory (IRT), and Network Analysis (NA), to reduce measurement errors and improve the detection of treatment effects, potentially resulting in larger effect sizes.  Objectives include analyzing the psychometric properties of PANSS and BPRS using FA, IRT, and NA to reduce error and improve symptom assessment accuracy, and investigating whether these improved models yield larger effect sizes in clinical trials. These efforts align with the EU’s focus on better mental health outcomes through enhanced treatment strategies.  The project is structured into two key work packages: WP1: Focuses on psychometric evaluation of PANSS and BPRS using data from multiple randomized clinical trials, aiming to refine these tools and explore symptom differences across gender and ethnicity. WP2: Applies the refined models to existing trial data, comparing traditional and psychometrically-informed effect sizes to assess improvements.  The skills gained through this fellowship will equip me to become a leading expert in psychometric applications for psychiatric disorders, particularly schizophrenia. The combination of research and training will prepare me for a future role as a principal investigator/research director, allowing me to lead innovative projects that advance the field of mental health research.  Ultimately, EVIDENTIAL could significantly improve clinical decision-making and the effectiveness of schizophrenia treatments.

Mots clés : schizophrenia, psychometrics, randomised trials, effect sizes, statistics

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 134284.32 €
Projet HEAD-P (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Deprescribing (reducing or stopping unnecessary or harmful medications) is an important strategy to reduce the risk of medication harm – a significant and growing challenge for health systems as acknowledged by the World Health Organization. The aim of HEAD-P is to establish the current evidence base on adverse drug withdrawal events (ADWEs) and explore how this can be enhanced via the pharmacovigilance system. HEAD-P consists of 4 research objectives: to assess the rate of ADWEs in published trials of deprescribing; to examine the incidence of adverse events reporting related to ADWEs; to identify and review all recommendations related to the monitoring, detection, and reporting of ADWEs; and to investigate healthcare professional, patient, and policymaker perspectives on the integration of ADWE reporting in the pharmacovigilance system. The following research approaches will be employed: an umbrella review of systematic reviews, disproportionality analysis of key pharmacovigilance databases, a scoping review of sources of guidance, and qualitative semi-structured interviews. This innovative research will help address the significant gap in our knowledge of ADWE occurrence and will stimulate future studies and innovations. Moreover, this fellowship will provide me with valuable scientific (protocol development, quantitative data analysis relevant to pharmacovigilance data, qualitative research methods, data management, and synthesis skills) and transferrable (grant writing, research communication, and supervision and mentoring skills) skills. It will also provide me with valuable international, intersectoral, and interdisciplinary experience, and allow me to develop leaderships skills. The skills and experience I will gain by completing this Fellowship in the host organisation (RCSI), will help me achieve my ultimate career goal – to become a leader in pharmacovigilance research and development in academia or a medicines regulatory agency.

Mots clés : deprescribing, drug withdrawal events, pharmacovigilance, adverse drug reactions, healthcare professional, patient, and policymaker perspectives, qualitative research, quantitative research

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet SSpaceGX (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project aims to analyze the social space of nature conservation in the Gerêz-Xurés Transboundary Biosphere Reserve at the borders of Portugal and Spain. To do so, it will be necessary to incorporate an entirely new methodology into classical social space studies in order to account for the environmental dimensions of social dynamics. Specifically, advanced geo-spatial analysis combined with ethnographic approaches, will be added to geometric data analysis (mainly, the established methodology for the social space construction). This contribution is based on the parameters of a non-intrusive approach to living conditions proposed by Virgilio Borges' research team at the Institute of Sociology in the University of Porto (Ramos et al, 2021) . The inclusion of the environment into the social space of nature conservation will lead to the development of a new approach to current ecological problems. As a result, the research findings will provide alternatives to understand, prevent, and manage the main conflicts facing sustainable development in the Gerêz-Xurés Transboundary Biosphere Reserve. In sumary, the social space of nature conservation aims to model the social-environmental interdependencies surrounding a biosphere reserve by a strong synergy of spatial, statistical, and ethnographic methodologies. This social space can be replicated, compared, and improved in its operation in other biosphere reserves of the world.

Mots clés : biosphere reserve, social space, nature conservation, sustainability, spatial analysis, multivariate statistics

Participants :
- Institut de Recherche et d’Innovation en Santé de l’Université de Porto (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
Projet MitoMemInsert (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Mitochondria perform numerous key functions, from energy production to metabolic pathways, and are involved in ageing and cell death. All these functions rely on about 1000 different proteins, of which 99% are synthesized outside the organelle and have to be imported and inserted into the right compartment. These import and insertion are particularly demanding for the membrane proteins as they are inherently aggregation-prone. How α-helical membrane proteins (MPs) are inserted into the mitochondrial outer membrane (MOM) is currently poorly understood. In particular, the structure of the insertase responsible for inserting tens of these α-helical MPs into this membrane, called mitochondrial import protein (MIM) in yeast, is unknown. My MitoMemInsert project addresses this important knowledge gap, by determining the atomic-resolution structure of MIM, by using cryo-EM combined with magic-angle-spinning nuclear magnetic resonance spectroscopy to resolve MIM’s structure in a lipid-bilayer environment. This will open avenues to see how the MIM complex engages with polypeptides that shall be inserted into the membrane by MIM (so-called precursor proteins or ‘preproteins’). Such a “static” structure determination would already be a big leap for the field: it will be the first structure of a MOM insertase of α-helical MPs. As it is thought to have a novel architecture, this structure will provide new insights into MP insertion machinery in general. In addition, I will use NMR to study the dynamics of this machinery, which I believe, will add important mechanistic knowledge of how the MIM complex engages with MPs that are being inserted in the MOM. Overall, making use of my previous technical expertise, and adding new competences to my skill set, a combination of biophysical and structural approaches will allow me to resolve this important, and hitherto poorly addressed question in mitochondrial biogenesis and, more generally, biophysics.

Mots clés : mitochondrial import protein mim cryo em ssnmr dynamics cell free translation system

Participants :
- Institute of Science and Technology Austria (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199440.96 €
Projet cryoSPARTAN (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cell motility is driven by a complex network of force-generating biological machinery. The key component in this machinery is the dynamic network of filamentous actin (F-actin) and actin binding proteins (ABPs) which maintain and regulate the network. However, structural information for many ABP-actin complexes, as well as their in situ spatial distribution remain elusive. This is because ABPs cannot be easily studied in isolation, often exhibiting structural stability only when embedded in a complex filamentous network found within cells. This has hindered a complete understanding of actin network regulation in cell migration. Addressing this important question requires understanding exactly how ABPs select F-actin, and conversely how F-actin geometry recruits specific ABPs. Cryo-electron tomography (cryo-ET) can reveal both cellular ultrastructure and molecular details, but often is lower resolution than a single particle cryo-EM approach. Thus, innovative methods remain key to drive advancement in understanding in situ structures. In this fellowship I will combine my expertise of single particle cryo-electron microscopy with expertise of cryo-ET in the Schur lab to develop a novel hybrid single particle cryo-ET approach in order to reveal high-resolution structures and contextual information of ABPs bound to F-actin directly within cellular protrusions. ISTA is the ideal research institute due to abundant access to high-end electron microscopes necessary for methods development. The outcome of this action are tools for high resolution in situ structure determination and a better understanding of cell migration, a process deeply rooted in malignant metastasis. Results will be disseminated through key research conferences and high-impact open-access publications. Communication activities will be achieved through 3D rendered visual scientific illustrations targeting social media platforms and institute-organized public outreach events.

Mots clés : cryo electron microscopy, actin cytoskeleton, methods development, ultra structure, cell migration

Participants :
- Institute of Science and Technology Austria (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199440.96 €
Projet SLAVESRELIGION (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

SLAVESRELIGION is an interdisciplinary proposal aimed at understanding the process of implementation, exploitation and perpetuation of slavery in the properties of the Luso-Brazilian Benedictine Congregation between 1750 and 1871, highlighting issues related to Gender, Race and Slavery in the Atlantic world. It also intends to analyse the resistance strategies built by enslaved men and women against the disciplinary and moralising measures of the Order of Saint Benedict. The project aims to demonstrate that this Congregation played an important role in the construction of modern slavery, transforming it into one of the richest and most powerful Slave Orders in Brazil. The Benedictines built efficient and durable strategies for managing slaves through measures designed to control female behaviour, access to freedom, and reproduction. Despite the importance of this Congregation in the construction of modern slavery, few historians have analysed its peculiarities. There are indications that this Religious Order encouraged its slaves to own slaves. Moreover, there is also evidence that they encouraged enslaved women to reproduce in exchange for benefits (especially freedom). Besides, there are suggestions that they allowed slaves to accumulate patrimony and pass it on by inheritance to their heirs. The results of this research will be disseminated through various means, such as social media, digital platforms and seminars, among others. When concluded, the research will render three scientific articles on the peculiar slave management of the Benedictines and the resistance strategies of the enslaved population, with a special focus on slave women.

Mots clés : benedictine congregation slavery gender resistance paternalism atlantic world brazil

Participants :
- Université de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
Projet A-TARGET (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Rapid auxin responses initiate cellular changes, which are important for rapid, auxin-induced root growth inhibition and root gravitropism. Accumulating evidence shows that these rapid responses are mediated by TIR1/AFB signaling: Auxin enters the cell by influx or diffusion and activates the AFB1; within seconds, AFB1 activates a trio of tightly connected rapid responses, including PM depolarization, CNGC14-dependent cytosolic Ca2+ increase, and apoplast alkalinization, which lead to rapid root growth inhibition. However, how AFB1 mediates these rapid cellular responses via CNGC14 remains unknown. Until recently, my host lab found that TIR1/AFBs have additional Guanylate cyclase activity and that its product, cGMP, rapidly and transiently increases in roots after auxin treatment. Importantly, application of cell-permeable cGMP triggers cytosolic Ca2+ increase in a CNGC14-dependent manner and rapid root growth inhibition in Arabidopsis. These observations collectively imply a linear AFB1 - cGMP - CNGC14 - Ca2+ non-transcriptional signaling pathway, which explains well at least part of the mysterious rapid auxin responses. However, how the auxin perception product, cGMP regulates CNGC14 and orchestrates Ca2+ influx is still unclear in planta. Thus, filling this major knowledge gap is eagerly awaited and will open entirely new possibilities for a mechanism of cytosolic Ca2+ oscillation in planta. In this proposed research, I aim to test the hypothesis that AFB1-generated cGMP acts as a second messenger, targeting CNGC14 to trigger rapid auxin responses in plants. We will i) clarify the binding between cGMP and CNGC14 in vitro and in vivo; ii) test the importance of cGMP binding to CNGC14 functions in plants; iii) explore the mechanism, by which cGMP regulates CNGC14. My investigation will not only be a significant step in our understanding of non-transcriptional auxin mechanisms but will have huge implications for other rapid, Ca2+-dependent cellular responses.

Mots clés : arabidopsis rapid auxin response cgmp second messengers cngc14 calcium transients rapid root growth inhibition root gravitropism

Participants :
- Institute of Science and Technology Austria (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230184.72 €
Projet EPH-FEM-PI (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Social media platforms, like Instagram, allow for a wide range of people – including those outside traditional activist circles – to create or engage with feminist content within quotidian social media practices, with political content co-existing with personal, mundane, or aesthetically-oriented content. This project will explore how online feminist practices take shape in increasingly popular yet under-researched practices of ephemeral social media by focusing on Instagram Stories, exploring the new dynamics these carry. This project explores the under-studied local context of Portugal. Portugal is experiencing a moment of political polarisation, which is reflected in its social media landscape. Feminist and political discourses are common on Instagram yet often met with backlash from conservative or right-wing voices. This is a rich and novel site for the analysis of these dynamics, revealing local particularities that are absent from Anglo-Saxon contexts. This project addresses three research objectives: analyse how feminisms are expressed through ephemeral social media affordances; explore what conventions and concerns underly the creation of feminist content; and examine how audiences engage with feminisms on Instagram. This project proposes an innovative ethics-driven, multi-methodological approach. It combines qualitative strategies with the use of digital tools for an exploratory analysis of feminist Instagram Stories; in-depth interviews with feminist content-creators; and focus groups with social media users who engage with feminist content on Instagram.

Mots clés : instagram online feminism ephemeral media portugal multi methods

Participants :
- Université Lusófona (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
Projet AlgeTopo (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The primary goal of the current proposal is to understand the structure of atomic nuclei and its evolution by means of algebraic and topological approaches, and to employ the algebraic approach to Quark Gluon Plasma. The algebraic approach can offer considerable insight into complex dynamics by classifying underlying symmetries, derive selection rules, calculate many observables and predict many properties in nuclei in a tractable manner. The topological approach can offer new insight into the phases of matter of the nucleus.The different objectives of the proposal are "Monte-Carlo code for interacting fermions and bosons": we will develop a new open-access code for numerical calculations of fermions and bosons using the Monte-Carlo method. "Mapping the Shell Model (SM) onto the Interacting Boson Model (IBM)": we suggest a novel mapping approach based on effective field theory (EFT) in which we write the SM and IBM in EFT and investigate the structure of Lie algebras of the Feynman integrals, a method used for calculating multiloop radiative corrections, and use them to map the SM onto the IBM. "Topological phases of atomic nuclei": we will investigate the occurrence of Berry phases in semi-magic mid shell nuclei and find classes of topological orders in atomic nuclei by examining known and new analogies with condensed matter physics. "Algebraic approach to QGP": we will introduce a new algebraic model for QGP based on boson-fermion effective degrees of freedom with similar principles as the interacting boson-fermion model for atomic nuclei, in order to calculate the phase diagram in a tractable framework with insight to the symmetries of the diagram. The above objectives can spur more studies by the researcher, the supervisor and other experimental and theoretical research groups in different fields of physics and thus the researcher asks for their funding.

Mots clés : interacting boson model, nuclear shell model, group theory, topological orders, quark gluon pasma

Participants :
- Commissariat à l’énergie atomique et aux énergies alternatives (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €