Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet EUROPROP (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This project is the first attempt to create a theoretical account of female prophecy in sixteenth century Italy, Spain and England as a key to understanding crucial political concepts such as authority, discipline, spirituality, agency and expectation. It identifies sixteenth-century Italian ‘living saints’ and humanists; Spanish beatas and conversas; and English visionaries as privileged actors of prophetic charisma and challenges assumptions that prophecy responds just to national or local interests and debates. A transnational approach is needed to demonstrate the close parallels and exchanges in Italy, England and Spain in this era of extensive religious mobility. Without neglecting the differences, this project explores the circulation of female prophecy in Italy, England and Spain before the Universal Church was completely divided. The analysis will concentrate on a corpus of women prophets, i.e. the texts written by women prophets and their male counterparts (confessors, hagiographers and devotees), as well as by secular women (such as humanists) in order to identify interconnections and models of female prophecy in early modern religion. This corpus includes sermons, visions, spiritual letters and poems, hagiographies and inquisitorial trials. The project’s supervision by Unn Falkeid, historian of ideas at the University of Oslo, and by Nicholas Terpstra, social-cultural historian at the University of Toronto, as well as the excellent research environment of the host institutions, will ensure the project’s success. The University of Oslo hosts a growing research team on Renaissance and early modern women and religion, and so is the most fitting environment to carry out my project during the return phase. The University of Toronto (outgoing phase) is the perfect place in which to acquire new methodologies and archival sources, thanks to Terpstra’s expertise, to its digital humanities structures and its centers for the study of the Renaissance and Reformation.

Mots clés : prophecy, religion, women, early modern europe, reformation, counter reformation, history of concepts

Participants :
- Université de Toronto (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 275523.36 €
- Université de Bologne (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Condensates (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Biomolecular condensates are membraneless organelles that serve as specialized phase-separated microenvironments within which many cellular processes can occur efficiently and with precise spatial and temporal organization. As such condensates are an important target for scientific research because they can be used as regulatory mechanisms to turn cellular processes on or off. Condensates comprise flexible multivalent biomolecules with multiple binding sites. This allows them to interact with various molecules simultaneously, enabling biomolecular clustering that can lead to phase separation. Kinase phosphorylation is a critical mechanism that triggers formation and dissolution of condensates. Once formed, condensates display emergent properties, which arise due to the collective behavior of their component biomolecules. I propose to investigate the mechanism of consecutive catalysis by kinases within condensates, and how the properties of condensates affect kinase activity. I will use synthetic condensates containing a minimal model kinase substrate that strongly partitions Protein Kinase A to examine kinase reaction kinetics in vitro and in vivo. The experiments described within will elucidate whether kinase catalysis proceeds distributively or processively within condensates. The proposed research will identify the fundamental principles of kinase-dependent condensate regulation, particularly the impact of multi-site phosphorylation on the regulatory dynamics controlling condensates. Since condenstates and kinases form a mutually responsive system regulating many basic aspects of cellular physiology, understanding how they interact will provide greater knowledge of disease mechanisms. By unraveling the intricacies of these molecular interactions, I will uncover novel insights into cellular regulation that can be used to develop innovative therapeutic strategies to address current challenges in health and disease, such as cancer and neurodegenerative disorders.

Mots clés : biomolecular condensates, membraneless organelles, phase separation, intrinsically disordered proteins, kinases, enzyme kinetics, phosphorylation, signaling pathways

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet COLOSSAL (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Agricultural soils are the primary human-induced source of atmospheric nitrous oxide (N2O) emissions, a potent greenhouse gas and the most significant damaging substance of the ozone layer. Climate change and the projected increases in food demand, agricultural land area, and fertilizer use are expected to increase N2O emissions over the coming decades. However, the actual magnitude and the key-influencing factors remain highly uncertain. COLOSSAL will develop an innovative models-driven framework to improve global quantification and understanding of N2O emissions from agricultural soils. First, I will produce comprehensive databases of N2O emissions and crop productivity at site- and regional-scale, establishing the foundation for subsequent steps. Second, I will use an advanced terrestrial biosphere model for a mechanistic-based quantification of global N2O emissions from agricultural soils, covering historical and current time periods. Third, I will implement interpretable machine-learning models to unravel the key drivers and estimate N2O emissions globally, including plant-soil-atmosphere interactions and management practices. Finally, I will unfold future N2O emission scenarios by incorporating climate change projections and mitigation practices into the terrestrial biosphere model informed by interpretable machine-learning models. COLOSSAL, stemming from 3 leading multi-disciplinary research groups, will take place during the 2-year outgoing phase at the Massachusetts Institute of Technology including an 8-month secondment at Boston College (USA), and 1-year return phase at Aarhus University (Denmark). Overall, COLOSSAL will advance our understanding of N2O emissions from global agricultural soils, contributing decisively to the design of more effective strategies for mitigating worldwide greenhouse gas emissions in the future.

Mots clés : nitrous oxide, emissions drivers, crop production, climate change, models framework

Participants :
- Boston College (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut de technologie du Massachusetts (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 309951.36 €
Projet PRECAP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

This PRECAP project aims to revalorize cherry waste (Prunus avium L.) from agricultural industry by bringing a new approach to the European circular economy. PRECAP by encapsulating prebiotic bioactive compounds extracted from cherry waste (dietary fiber and proanthocyanidins) and acetate producing bacteria (Bifidobacterium or Lactobacillus, that consume these biocompounds), seek to restore the health concentrations of butyrogenic bacteria in the intestinal microbiome, which consume acetate by cross-feeding to produce butyrate. The project stands out for its innovation in the development of functional capsules to prevent or mitigate inflammatory bowel diseases derived from the reduction of butyrate produced by the intestinal microbiome. Furthermore, this is enhanced by the healthy nutraceutical effect of phenolic compounds and dietary fiber extracted from cherry waste. The design of this functional capsule of potential probiotic bacteria that produce acetate together with prebiotics from cherry waste, added to the application of a scalable encapsulation methodology (spray-dryer), could be the basis for the development of functional foods from agro-industrial waste. Acetate-producing bacteria are more aerotolerant than butyrogenic (strictly anaerobic) bacteria, which would allow more feasible scalability and management projection in the food industry. Finally, PRECAP is expected to improve the competitiveness, sustainability, and circular economy of agri-food chains, and be a viable alternative to improve people's health.

Mots clés : cherry waste, prunus avium l , prebiotic, circular economy, acetate producing bacteria, cross feeding, encapsulation, functional food ingredient, butyrogenic bacteria, inflammatory bowel diseases

Participants :
- Government of Extremadura (Espagne) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université d'Estrémadure (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 242593.2 €
- Wellcome Trust (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet SEAL (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The design and evaluation of mechanisms for aggregating preferences is a central problem in Multi-Agent Systems (MAS). In such setting, we need to be able to aggregate individual preferences, which are conflicting when agents are self-interested. More importantly, the mechanism should choose a socially desirable (or "good") outcome and reach an equilibrium despite the fact that agents can lie about their preferences. The real-world applications of designing and verifying mechanisms for social choice are manifold, including fair division protocols, secure voting, and truth-tracking via approval voting. Although logic-based languages have been widely used for verification and synthesis of MAS, the use of formal methods for reasoning about auctions under strategic behavior as well as automated mechanism design has not been much explored yet. An advantage in adopting such perspective lies in the high expressivity and generality of logics for strategic reasoning. Moreover, by relying on precise semantics, formal methods provide tools for rigorously analyzing the correctness of systems, which is important to improve trust in mechanisms generated by machines. This project aims to design a logical framework based on Strategy Logic (SL) for formally verifying and designing mechanisms for social choice. More specifically, we aim at (i) proposing an approach addressing the probabilistic setting (with Bayesian information, stochastic transitions and mixed strategies); (ii) identifying fragments of SL that enjoy both good complexity and satisfying expressive power for being applied to classes of mechanisms; (iii) modeling and reasoning about relevant problems from the state-of-the-art in computational social choice using the proposed logical framework; and (iv) methodically studying the obtained fragments in relation to the expressivity, model-checking and satisfiability problems.

Mots clés : strategic reasoning, logics for multi agent systems, mechanism design, social choice, formal methods, model checking, synthesis

Participants :
- Université de Naples - Frédéric-II (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet AMPD (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This project will develop the At-home, Maximised Potential DNA/RNA Detecting Device (AMP’D). AMP'D is a hand-held, equipment free point-of-care device that can detect DNA/RNA biomarkers in easily accessible bodily fluids - such as blood, nasal and saliva samples. It is intended for diagnosing both infectious diseases and cancer. Additionally, it can do it at-home and early in disease progression.  Both infectious diseases and cancer are leading causes of death globally. In 2020, cancer accounted for 10 million deaths. Furthermore, Covid-19 alone has accounted for 6.5 million deaths since the start of the pandemic. AMP'D intends to significantly reduce the number of deaths for both diseases - by providing a platform that can allow for ultra-sensitive, low cost and convenient detection. First, AMP'D can detect extremely low concentrations of biomarkers - at the early stages of these diseases. Second, AMP'D can cut the cost of each test from US$200 (commonly observed with pathological lab tests) to US$10. Finally, AMP'D can enable at-home diagnosis with blood, nasal and saliva samples - thus preventing invasive/uncomfortable procedures that deter many people from getting tested until it is too late. The development of such a device can enable end-users anywhere in the world to detect these diseases - even before symptoms appear. This can allow for early intervention before prognosis worsens - thus saving lives.

Mots clés : diagnostics, biosensors, lab on a chip, poc miniaturisation, nucleic acids

Participants :
- Université de Naples - Frédéric-II (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet SUBCARB (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Despite containing the vast majority of carbon on the planet, the Earth’s subsurface represents a mostly uncharacterized frontier for biogeochemistry and microbial ecology. While carbon fixation at the Earth’s surface has been drawing a lot of attention for decades, subsurface carbon fixation remains poorly understood. Yet, metabolically, it engages a rich diversity of non canonical pathways, contrasting to surface carbon fixation dominated by the canonical Calvin cycle. Also, its contribution to the global carbon cycle, though long overlooked, is now garnering increased attention. In recent years, several studies aiming to characterise the diversity of carbon-fixing organisms within the subsurface have emerged. However, these studies are isolated and do not accurately describe the dependence of these metabolisms on the geoenvironmental context. I propose here to provide a blueprint of subsurface carbon fixation on Earth. In a top-down approach, I will systematically sample various subsurface environments for metagenomic and metaproteomic analysis of carbon fixing metabolisms, in search of the main environmental factors determining the carbon fixation strategy used. In parallel to this, I will undertake a bottom-up experimental approach to explore and confirm this metabolic versatility in response to changing environments, through controlled culturing experiments. Finally, I will integrate the acquired results with stable isotope analysis to build a metabolic model, aiming to comprehensively predict carbon fixation fluxes in function of the geoenvironmental context. The proposed holistic approach will increase our understanding of the role of subsurface microbial metabolisms in global carbon cycling.

Mots clés : carbon fixation subsurface environments metagenomics metaproteomics flux balance analysis

Participants :
- Université de Naples - Frédéric-II (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet VascularROM (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Mathematics
Statut du projet : SIGNED

Cardiovascular diseases are the leading cause of death globally, and risk factors for numerous pathologies of the circulatory system are continuously increasing. Medical treatment options and diagnostics improve, where especially the recent advances in data-driven numerical methods for clinical support bear great potential. Computational fluid and solid mechanics play a key role in gaining insight into the complex physics, but even highly efficient traditional schemes do not fit into the clinical timeframe.  This project aims to develop reduced order models targeting the vascular system, considering for inter-patient variability. Following this approach, a compute-intense offline phase constructs suitable physics-consistent surrogate models, which deliver faithful approximations in near-real-time to be queried by the user in the online phase. The state of the art in model order reduction of the vascular system is extended by considering for global geometric variability, advanced material models and parameter fields for blood and tissue as well as their coupling to derive patient-specific biomarkers of clinical relevance within seconds.  These developments will not only open the path to transforming the role of numerical modeling in clincial practice, but will further build a starting point for the computational science and engineering community by providing open-source implementations based on highly efficient, modern finite element codes and accompanying tutorials to foster future developments and initiate momentum.  The proposed project encompasses an outgoing phase at the Oden Institute, UT Austin, where the ambitious project goals are persued together with advisors Prof. K.E. Willcox and Prof. T.J.R. Hughes, two of the most influential experts in computational science and engineering. The developed reduced order models are then further tailored to the clinical scenario at TU Graz’s Institute of Biomechanics, validating their applicability.

Mots clés : model order reduction, continuum mechanics, computational fluid dynamics, cardiovascular diseases, patient specific simulation, non newtonian fluid, hyperelasticity, fluid structure interaction

Participants :
- Université du Texas (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université technique de Graz (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 332299.44 €
Projet LATTICE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

EU's ambition of achieving climate neutrality by 2050 requires multifaceted approach, with a key focus on replacing fossil fuels with renewable energy sources. In this respect, thermoelectrics (TE) offers a promising solution by converting waste heat into electricity – contributing to global energy base – while addressing environmental challenges through decarbonization. A major barrier in the broader implementation of TE is the need for high-performance materials. Silver chalcogenides Ag2X (X: S, Se) have recently shown excellent TE performance near room temperature (RT: 300 K – 400 K) owing to inherently low heat conduction (κ). Despite this, our understanding of their low κ and their stability in the harsh operational conditions of a TE device remains uninvestigated. These aspects pose a significant challenge in advancing Ag2X as a viable alternative for TE near RT. LATTICE is a career development program designed for the researcher, aimed at developing structure-property relations in Ag2X to address stated fundamental and application-based aspects. To successfully achieve the goals of this interdisciplinary project, the researcher will undergo advanced research training in the host group – pioneer in TEs – at EU’s leading University. The researcher will benefit from host’s strong expertise in studying materials’ structure by a wide range of experimental and theoretical methods and techniques. This opportunity will foster researcher’s growth in TE and materials science, positively impacting his long-term career trajectory. If successful, the project will unravel new knowledge of heat conduction in Ag2X and evaluate stability by unique measurement setup; emulating TE device operation conditions. LATTICE’s research output will benefit colleagues working on other type of energy conversion devices that employ Ag2X. New knowledge on Ag2X will attract EU-based SMEs involved in R&I to develop near RT heat-capturing TEs, progressing economy towards sustainability.

Mots clés : thermoelectric materials correlated disorder structure property relations energy conversion solid state materials p5

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 263393.28 €
Projet FTOSC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

I intend to travel to the University of Oxford and the lab of Prof. Moritz Riede and build a second-generation version of indium tin oxide (ITO)-free flexible transparent electrodes (FTEs), which I have designed and built during my PhD studies at the University of Hong Kong in Hong Kong SAR. This will be designed not only to note excellent flexibility but also emphasize (1) excellent electrical and optical properties (i.e. sheet resistance <15 Ω sq.-1 and diffuse transmittance >90 %), (2) extremely smooth surface roughness (i.e. PtV <5 nm), (3) enlarged surface conducting channels, and (4) on-demand surface work function covering p- and n-type semiconducting properties, leading to a higher figure of merit (FoM) compared with industry-standard ITO on a glass substrate. In addition, an intermediate recombination layer (IRL) concept that electrically connects two sub-cells in a tandem cell will be devised by using arbitrary hole and electron transport layers (HTLs and ETLs) to advance consecutive manufacturing processes in a facility system without using the PEDOT:PSS. Once complete, I intend to break the record power conversion efficiency (PCE) of flexible tandem organic solar cells (FTOSCs) consecutively manufactured by solution (>20 %) and dry (>12 %) techniques respectively based on the developed on-demand p- and n-type ITO-free FTEs in this proposal, resulting in higher PCEs compared with the identical rigid tandem cells based on the rigid ITO. In addition, robust mechanical operation of the FTOSCs (>90 % PCE retention) under >36.5 k cycles (one year of use, if used 100 times a day) of repeated bending to a radius of 1.4 mm (e.g. Galaxy Z fold 2) based on the developed FTEs will be achieved under AM 1.5 G illumination standard for approximately 12 hours (time difference between sunrise and sunset). Finally, a large area for portable device scale (6-inch) for the ITO-free FTEs will be demonstrated by exploiting the unique spray coater in the host group.


Participants :
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €