Projet ZENITH (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

A fundamental challenge for Neuroscience is to understand how neural circuits process information from the outside world and internal physiological states, to produce versatile but reliable behavior. Two major research challenges are: 1) the complexity and distributed nature of neural circuits; 2) the need for data spanning multiple scales from molecular and activity phenotypes of single cells through to circuit connectivity and population dynamics and finally the behavioral output itself. The goal of the ZENITH ETN, “ZEbrafish Neuroscience Interdisciplinary Training Hub”, is to understand how neural networks mediate perception and behavior. We will exploit the advantages of zebrafish as a small transparent vertebrate with superb genetic accessibility and use cutting-edge technology to elucidate the interactions between molecules, cells and entire networks that ultimately generate adaptive behavior. Our training goal is to create collaborative, interdisciplinary young scientists who can tackle major challenges within neuroscience research. Training in cutting-edge technologies and analytical frameworks will enable this next generation of researchers to perform integrated, multi-scale analyses to elucidate the neural basis of naturalistic behavior. Training is centered on highly collaborative projects between physicists, mathematicians and biologists that will expose ESRs to broad training with academic and industrial partners. Advanced optical methods and genome-editing will be utilized to link molecules to circuits, to map connectivity between cell types across the nervous system and to build computational models of brain activity that will be experimentally tested. Overall ZENITH will help to change the way young scientists are trained in Europe and provide the conceptual, technical and analytical skills needed to take on the challenge of understanding how the beautifully complex circuits of the vertebrate brain control behavior.

Mots clés : neural circuits, sensory motor integration, naturalistic behavior, zebrafish, data driven models

Participants :
- Centre for Genomic Regulation (Espagne) — Partner, beneficiary, Recherche, subvention : 250904.88 €
- Phaseview (France) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut du cerveau (France) — Coordinator, beneficiary, Recherche, subvention : 549604.08 €
- Miltenyi Biotec (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- ZeClinics (Spain) (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 250904.88 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 909517.68 €
- University of Edinburgh (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
- Champalimaud Foundation (Portugal) — Partner, beneficiary, Recherche, subvention : 237720.24 €
- Technical University of Munich (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- Charité - Universitätsmedizin Berlin (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- Pompeu Fabra University (Espagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Intelligent imaging innovations gmbh (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Osha bwb (France) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Imagine optic (France) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Harvard University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Universidade Nova de Lisboa (Portugal) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 264207.24 €
- Max Planck Society (Allemagne) — Partner, beneficiary, Recherche, subvention : 0.0 €
- Institut de recherches servier (France) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Sorbonne Université (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 824406.12 €
- Utah System of Higher Education (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Springer Nature (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €