Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CRISMET (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Statut du projet : SIGNED

Months into the Covid-19 pandemic, it is clear that global society is faced with an emergency of not only health, but of social mobilisation and communication, unfolding in paths we are only beginning to discern. Emerging research suggests that the pandemic is bringing a major reframing of notions of collectivity and national belonging, where a figurative, metaphorical political rhetoric is paving ways to sweeping ‘coronationalisms’, across Europe. Certainly timely and appropriate, the academic and citizen interest in language of the crisis points to public discourse metaphoricity as a new challenge for crisis research globally. By locating the analysis in the post-Yugoslav, post-socialist area, where persisting nationalist tensions mix with pandemic discourses in complex ways, this project lays the foundations for interdisciplinary, language-driven study of crisis discourse grounded in the role of metaphor for rooting perceptions of the past, present and future. The project thus addresses objectives on two levels: (1) exploring the (re)framings of collectivity, national belonging and nationalism in the post-Yugoslav political, media and citizen discourses, and (2) introducing a multi-dimensional metaphorical methodological approach to public discourse analysis, bringing together cognitive-linguistic metaphor study and social science study of politics, history and cultural memory, as an adaptable interdisciplinary model suited to approaching discourses of crisis and social transformation. The analyses, methodology and dedication to public debate together are expected to pave the way to rethinking effective crisis communication in this and other looming crises, by drawing on our pioneering insights on the conceptual role of language in mapping the real and symbolic borders and connections of (post-)pandemic Europe.

Mots clés : discourse analysis, public discourse, metaphor, ideology, nationalism

Participants :
- Slovenian Academy of Sciences and Arts (Slovénie) — Coordinator, beneficiary, Recherche, subvention : 162040.32 €
Projet DATASOUND (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

More and more, organizations are generating huge amounts of data, which need to be stored and processed in order to gain useful insights and achieve competitive advantage. While the storage and analysis are nowadays mostly carried out by computers, the interpretation of data is still performed by humans through visual means. This research project proposes a novel and complementary approach to data interpretation by means of sound, and aims to address the scientific question of “Can sound be used for Data Science?”. Its results will be of relevance to identify patterns in real-time continuous data, and it will be tested in the context of real-time energy monitoring in a building. The project will provide the researcher the resources and training for creating and managing a pioneering research lab on data Sonification at the Data Science Institute, Imperial College London.

Mots clés : data sonification, energy monitoring, data representation

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet SUSTIMAR (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

More than 30% of the biomass landed by fishing fleets in the ports of Spanish coast constitutes a waste not usable for human consumption, resulting in hundreds of thousands of tons/year of by-products that must be managed urgently to avoid serious environmental pollution problems. To this biomass, we must add the fishing discards that the recent EU policy forces to land in ports. Most of these by-products are used in the production of fish meals, generally of low quality in Spain, in which the biomass undergoes a low valorisation level. Although this type of treatment is necessary to account for some fractions exhibiting low added value, there are other alternatives that maximise the obtaining of compounds of high commercial interest in diverse sectors of application. In this context, the main goal of this IF is to assess different scenarios of valorisation of marine biomass including the design, optimisation and integration of the biocompounds production processes with medium-high value added for the use as bioactive compounds of interest to the food, pharmaceutical or nutraceutical industries, by using more efficient as well as environmental and sustainable practices in a marine biorefinery concept. Based on previous experience with this type of raw material, processes and related methodologies, this project is essentially a research and a development action of optimised protocols for obtaining biocompounds that can be easily transferred to a potential industrial implementation.

Mots clés : sustainability, fishery by products and discards, valorisation processes, environmental impact, modelling, optimisation, integration

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 259398.72 €
Projet MetAeAvIm (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Mosquito-borne diseases remain among the most prevalent diseases in the world with. At present, more than half of the world population lives in areas where mosquito vectors are present. Vector control is one of the cornerstones of arbovirus control. However, insecticide-resistant population are emerging demanding new tools of vector control to be developed. It is known that mosquito immunity can be modulated by its physiological state and nutritional status. However, we still lack an integrated view of how immune mechanisms and metabolic pathways interact to control viruses at different stages of infection. In order to obtain a more detailed understanding of the gene expression profile associated with immunity to Dengue virus (DENV), we performed a genome-wide analysis of the transcriptome of susceptible and resistant individuals from the same population of mosquitoes. Metabolic pathways represented the majority of the differentially expressed gene sets identified by our analysis, suggesting that differences in metabolism determine DENV resistance. These results support the hypothesis that mosquito metabolism plays a key role in controlling mosquito susceptibility to viral infections. In this project, we will characterize the metabolism of mosquitoes and characterize pathways and genes that are determinants for DENV resistance. We will study the metabolism of A. aegypti, comparing susceptible and resistant mosquitoes, measuring specific metabolic outputs and also performing unbiased high-throughput metabolomic studies. In parallel, we will perform reverse genetic screenings to validate whether metabolic pathways and biological processes identified in our transcriptomic analysis have a role in vector competence to DENV. Finally, we will apply the CRISPR/Cas9 technology and classical transgenesis to target genes and pathways that affect vector competence in mosquitoes. Together, this project will allow for a deeper mechanistic study of mosquito antiviral immunity.

Mots clés : aedes mosquito dengue vector

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 184707.84 €
Projet CHLARABIDOX (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Most organisms exhibit a diurnal metabolic cycle, especially phototrophs, whose metabolism is strictly dependent on light. Dark-light transitions are accompanied by dramatic changes in the redox state of photosynthetic components, which drives redox-based post-translational modification of protein cysteines, whose oxidation state can considerably impact protein activity, and thus regulate metabolism. Given the central role of redox metabolism in biology, the operation of thiol-disulphide based switches are well-appreciated as a metabolic acclimation strategy, and the study of cysteine modifications in proteomes is a major interest of contemporary biology. The objective of CHLARABIDOX is to go beyond inventories of redox modified proteins by monitoring the proteome-wide dynamics of disulphide-dithiol status in the context of a diurnal metabolic cycle in phototrophic eukaryotes, specifically, the green alga Chlamydomonas reinhardtii and the land plant Arabidopsis thaliana. An innovative chemoproteomic isoTOP-ABPP approach will be used in an experimental design with deep temporal resolution to capture a good fraction of the proteome with site specificity and quantitative information about reactivity. The discoveries will be made in the context of a body of literature on thioredoxin-dependent redox regulation of central carbon metabolism, which will serve as a priori validation. The outcome of the project is a proteome-wide view of the operation of regulatory redox sensors, anchored to accompanying rich datasets on physiology, metabolic potential, transcriptomics, proteomics and central metabolites, which would inform the operation of light-driven metabolic networks. Both systems are compatible with downstream modelling of diurnal metabolic fluxes and validation by reverse genetics approaches. A long term impact on strategies for manipulating metabolism for biofuels production, or manipulating photosynthesis for better acclimation to climate change is also envisioned.

Mots clés : chlamydomonas reinhardtii, arabidopsis thaliana, redox proteomics, photosynthesis, systems biology of redox regulation, thioredoxin

Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Universidad de Sevilla (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 263732.16 €
Projet FuelHydrogel (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : TERMINATED

Most synthetic materials are close-to or reside-in equilibrium, however, life, the most ‘intelligent materials’ on earth, always stays away-from-equilibrium. This non-equilibrium state is usually sustained by high energy molecules (chemical fuels) harvested from metabolic reaction cycles. This has inspired the construction of chemically fueled dissipative molecular assemblies. Currently, these chemically fueled systems mainly focus on small molecules. Compared to small molecules, polymers show advantages in constructing 3D-bulk materials, as well as, integrating and amplifying molecular-scale changes to visible macroscopic changes. Thus, I propose to construct chemically fueled polymeric materials to overcome current limitations. A series of dextran-based chemically fueled hydrogels are constructed by coupling with appropriate analogue metabolic reaction cycles. The resulting hydrogels are responsive to chemical fuels and have the ability of self-healing and programmable decay. The life-time of the hydrogels is controllable by manipulating the kinetics of the reaction cycles. Controlled release of active ingredients (e.g. for drug delivery applications) from these hydrogels will be investigated. This fellowship will help me to reintegrate into the scientific community after maternity leave since 2017 in France. The project will be interdisciplinary as it ranges from the understanding of biological materials over polymer chemistry, systems chemistry, and organic chemistry to potential biomedical applications. It will also promote the two-way transfer of knowledge between me and the host.

Mots clés : chemically fueled hydrogels, reaction cycles, dextran, crosslinking, systems chemistry, dissipative

Participants :
- Aalborg University (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 219312.0 €
Projet PIADINE (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The first embryonic division of Caenorhabditis elegans is a powerful system to dissect the mechanisms governing asymmetric division, which relies on PAR-proteins for cell polarity and on dynein-dependant forces for centrosome and spindle positioning. In contrast to the extensive knowledge regarding proteins regulating asymmetric division, the contribution of plasma membrane tension, as well as of PIP2 and its modulators PPK-1 and CSNK-1 is poorly understood. I propose to decipher these questions as follows: 1) PIP2 is enriched in the embryo anterior in microdomains of the plasma membrane. I will test the contribution of PPK-1, the only kinase from the proteome converting PIP into PIP2 in formation of PIP2 microdomains distribution, cell polarity and pulling force. This will be achieved through ppk-1(RNAi) as well as two complementary optogenetic approaches to obtain acute spatiotemporal inactivation of PIP2. 2) I will decipher how the casein kinase CSNK-1 interacts with and phosphorylates PPK-1, thereby presumably regulating PIP2 microdomain distribution and function, as well as identify and characterize up to three CSNK-1 phospho-substrates with. 3) I will test whether PIP2 undergoes phase separation driven by a decrease in plasma membrane tension, and, if so, investigate the consequences on asymmetric division. Moreover, I will study the relationship between membrane tension and cortex contractility. 4) I will analyze asymmetric cell division in the one-cell Pristiochus pacificus embryo I will then use the knowledge acquired in C. elegans to conduct related experiments in P. pacificus, thus investigating potential conserved and divergent themes governing asymmetric division across nematode evolution. Overall, these experiments will shed critical light on the poorly understood contribution of PIP2 and its modulators to asymmetric division, an evolutionarily conserved process fundamental for development and stem cell lineages.

Mots clés : caenorhabditis elegans, one cell embryo, asymmetric division, pip2 distribution, ppk 1 and csnk 1 kinases, optogenetics, spatiotemporal control, membrane tension, pristionchus pacificus

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet FunGraW (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The first gravitational wave (GW) detections by the Laser Interferometric Gravitational-wave Observatory (LIGO) are an historical landmark. These detections opened a completely new window to the Universe and officially marked the beginning of GW astronomy. GWs travel almost unimpeded through the Universe, thus conveying clean information about their sources. This gives us a unique opportunity to test the nonlinear regime of Einstein’s theory of general relativity (GR) to unprecedented levels. Indeed, the GWs detected so far were emitted by the merger of binary black holes (BHs) which are the prototypical sources to investigate gravity in its most extreme regimes. However, the true potential of GW observatories to discover new physics beyond of current knowledge is far from being fully explored. In fact, besides probing the nature of compact objects and testing GR, GW detectors may also revolutionize our understanding of particle physics, dark matter (DM) and even possibly quantum gravity. At small scales, with the advent of precision GW physics we will be probing regions closer to the BH horizon, potentially ruling out or confirming alternatives to BHs that predict corrections at the horizon scale. On the opposite side of the spectrum, GWs may also give us hints about the nature of large scale anomalies, such as the existence of DM. For example, light bosonic fields around compact objects, i.e. BHs and neutron stars (NSs), can trigger superradiant instabilities and emit long-lived monochromatic GWs that can be used to either probe the existence of new particles beyond the Standard Model or, in the absence of detections, impose strong constraints on their masses and couplings. The prime goal of this proposal is to understand what GWs can tell us about fundamental questions such as the nature of compact objects and DM and ultimately to contribute to the recent theoretical efforts in developing the full scientific potential of the newborn field of GW astronomy.

Mots clés : strong gravity, superradiant instabilities, ultralight bosons, exotic compact objects

Participants :
- Sapienza University of Rome (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 168277.2 €
Projet NEXTGENPDF (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The first run of data taking at the Large Hadron Collider (LHC) at CERN culminated with the discovery of the Higgs boson announced in July 2012 and represented the beginning of a new era in high-energy particle physics. During the LHC Run II, which will start at the beginning of 2015 with the collider running at higher center of mass energy, the experimental collaborations will collect a large number of high quality data that will allow us to test our understanding of elementary particle physics to unprecedented levels and have the potential of revolutionizing our knowledge of fundamental physics. In order to fully exploit the potential of the experiments for precision studies of the properties of the Higgs boson and for searches of physics beyond the Standard Model it is of paramount importance to have access to accurate theoretical predictions for both background and signal processes. Parton Distribution Functions, which encode the information on how quarks and gluons are bound inside hadrons, are one of the fundamental ingredients of theoretical predictions for observables at hadron colliders. Indeed they are often the dominant source of uncertainties on predictions for precision observables at the LHC. The goal of the NEXTGENPDF project is to make use of all the relevant experimental information from the LHC experiments, the most accurate theoretical predictions, innovative techniques for estimation of theoretical uncertainties and advanced statistical inference methodologies to deliver new sets of Parton Distribution Functions that match the precision requirements of the experiments at the LHC Run II and at future colliders, maximizing their potential for discoveries of new physics.


Participants :
- University of Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 168277.2 €
Projet INFANTPATTERNS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The first weeks and months after birth are critical for early sensorimotor development, with brain injury at this time often resulting in the later development of long-term neurodisabilities such as cerebral palsy. Despite this, the evolution of control patterns in this phase of life has never been systematically studied, due to the technical difficulties associated with accurately measuring infant movements and motor commands. This project will thus: (i) measure for the first time the full body movements of preterm infants (using dedicated systems to accurately measure the force applied by the infants and their movement as well as high-density EMG); (ii) identify the infants' movement patterns and their evolution during this critical phase after birth. This ambitious project is feasible due to the extended expertise in human robotics of the supervisor at Imperial College London and the secondment with a strategic partner at the neonatal medicine department at Kings’ College London. This Marie Curie fellowship will give me a unique opportunity to create an innovative quantitative assessment and understanding of the developing motor function in infants, which has high potential for significant clinical and scientific impacts.

Mots clés : human robotics, preterm infants, motion capture, high density emg

Participants :
- Chalmers University of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191852.16 €
Projet TSCALE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The flow dynamics within turbomachinery flows are complex and still not fully understood. Such flows are rich in turbulent phenomena driven by high levels of unsteadiness. Despite much progress we are still unable to reliably predict many of these phenomena (e.g. wake interactions, transition, separations) using standard modelling techniques which hinders further aero-engine efficiency improvements. To investigate these phenomena, researchers are employing high-fidelity techniques both in experiments and in computations, e.g. direct numerical simulations. These techniques give unprecedented resolution and a wealth of data but extracting knowledge and distilling it into reduced-order models applicable to a wide range of flows is challenging, thus limiting their impact. The objective of this project is to address this limitation by adapting a theoretical framework of data-driven flow decomposition to turbomachinery flows. This methodology will be used to study inter-scale energy transfers between the different flow dynamics within the multi-stage compressor. The project aims to discern between scales contributing towards the turbulence production, dissipation and those regulating the flow of energy down the turbulence cascade. The analysis will be facilitated by combining multiple high-fidelity datasets from computations at engine representative conditions. The primary goal of the project is to establish a new paradigm for industrial flow modelling that utilises all the information embedded within the 3D unsteady flowfield. Consequently, a new set of low-order models will be derived, each catering to a different range of scales present in the compressor flowfield. The project will leverage the expertise of three world-leading groups in high-performance computing data decomposition and turbomachinery modelling. Results of this project are expected to provide much needed insight into multi-scale interactions in complex industrial flows such as those of aero-engines.

Mots clés : high performance computing, turbomachinery, multi stage compressors, turbulence, non equilibrium behaviour, data decomposition, multi scale modelling, reduced order models

Participants :
- University of Genoa (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 257209.92 €
- University of Melbourne (Australie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €