Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SMOOTH (Horizon 2020, appel à projets 2016)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : CLOSED

Over the years, changes in modern infrastructure have introduced new challenges to firefighting practices. Training and research programs have been developed to manage these challenges but there are still significant losses from fires each year. In 2013 alone, the fire departments in the USA responded to over 1.2 million fires which resulted in about 3,420 civilian fatalities, 15,925 injuries and property losses of about $12.4 billion dollars. In the UK, 192,600 fires responses, approximately 350 civilian fatalities, 10,300 injuries. The firefighting and rescue functions of the existing equipment and apparatus and their dexterity are limited, particularly in the harsh firefighting environments. The SMOOTH project aims to propose a novel robot-assisted decision making system in smart firefighting to perform searching and rescuing practice in the fire ground, and to facilitate the decision makings with higher efficiency. In the proposed system, a dexterous group of autonomous robots will be ingested, including an Octopus robot developed by SJTU with dexterous robotic upper body developed (with functions of high payload, forcible entry, excavation, obstacle avoidance and sweeping), a group of jumping robots invented by BU and YSU (with functions of obstacle avoidance) and a swarm of capsule systems invented by BU (with functions of precise positioning, narrow openings maneuveration and manipulation). A bunch of novel wearable and environmental sensors will be assembled and equipped on the robots and firefighter’s protection suits to facilitate the real-time machine-to-machine communications. A 3-D human-robot interactions infrastructure will be created to facilitate efficient interactions between human adaptive mechatronics and adaptive networked control. Based on these concepts, the consortium will investigate the needs and key technologies such as hybrid autonomous and miniaturized robotic modules, wireless sensor technologies, advanced decision support algorithms,

Mots clés : fire and rescue, firefighting, robotics, dynamic sensing

Participants :
- Chinese Academy of Sciences (Chine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institute of Solid Mechanics (Roumanie) — Partner, beneficiary, Recherche, subvention : 189000.0 €
- Cedrat technologies (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 45000.0 €
- Shanghai Jiao Tong University (Chine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Stimpex sa (Roumanie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 45000.0 €
- Robotnik (Spain) (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 45000.0 €
- Yanshan University (Chine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Bournemouth University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189000.0 €
Projet THORAX (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Owing to the poor seismic design and the absence of strict energy performance regulations, the vast majority of the existing old building stock in seismic-prone areas is not only highly vulnerable to earthquakes, but also energy demanding. Currently, structural and energy retrofitting of buildings is treated separately with no established holistic approach. An integrated retrofitting system using advanced composite materials combined with thermal insulation can improve the seismic and energy performance of buildings and offer savings in application costs (>25%). During the last two decades, the use of fibre-reinforced composite materials for structural retrofitting applications has gained popularity. The recent generations of advanced composites for construction have proven to be very effective in seismic retrofitting of structures. However, they are often expensive, lead to incompatibility issues, and promote the use of cement-based binders, of which the production largely contributes to the global CO2 emissions (5% of global man-made CO2 emissions). The main objective of THORAX is to develop the next generation of sustainable fibre-reinforced composite materials to be used for the combined structural and energy retrofitting of buildings, protecting the residents during earthquakes, whilst increasing their energy performance. The efficiency of this novel retrofitting system will be investigated through a multi-scale experimental campaign accompanied with a detailed numerical investigation. The host organisation has a leading expertise in the fields of fibre-reinforced composites and seismic retrofitting techniques. This project, along with training schemes available at the host university and secondment at a word-class research centre, will create great opportunities for the Fellow to develop his career as an independent researcher.

Mots clés : strengthening, rehabilitation, geopolymers, masonry infills, composite materials, energy retrofitting

Participants :
- University of Thessaly (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 153085.44 €
Projet FANSOC (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Oxidation of alcohols is one of the key reactions in the fine chemicals industry and is crucial for the conversion of biomass into valuable chemicals. Au catalysts demonstrate promising activity and selectivity in the aerobic oxidation of alcohols, however, they require addition of bases to operate at low temperatures, and often suffer from deactivation due to particle growth. Here I propose a strategy to circumvent these issues: employing Au catalysts supported on carbon materials with introduced basic surface groups. I will prepare and characterize a series of basic and novel “super-basic” carbon materials. Colloidally prepared gold nanoparticles will be deposited onto these supports, and the resulting catalysts will be tested for the selective oxidation of two relevant types of alcohols. Key will be the use of advanced characterization techniques to understand how the basic surface groups on the carbon affect the activity, selectivity and stability of Au catalysts in alcohol oxidation. I will address parameters such as changes in surface properties, shape and electronic properties of the Au nanoparticles, and changes in the adsorption strength of reactants, intermediates and products as a result of the different carbon surface functionalizations. The outcomes of this project will advance our understanding of the properties of Au nanoparticles supported on functionalized carbon materials, and in a broader sense generate insight into metal-support effects in catalysis, and hence facilitate the rational design of supported metal catalysts. Furthermore, this project will allow me to strengthen and expand my skills and expertise in the field of catalysis and materials chemistry, build professional network and establish my position as a researcher in Europe, which will help me to reach full independence in the future.

Mots clés : heterogeneous catalysis, gold, nanoparticle, carbon materials, selective oxidation

Participants :
- Utrecht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet PEARL (Horizon 2020, appel à projets 2018)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

PEARL, proposed by I-SITE ULNE, will target three main objectives: (1) training, in an interdisciplinary context, a generation of early-stage researchers (PhD students) for scientific and technical excellence and equipping them with unique skills in terms of transferable background, fully build on selected societal challenges needs. (2) implementing innovative actions aimed at boosting the careers of PhD students, exposing them to inter-sectorial (via a strong network of public and private organisations) and international mobility (taking advantage of a unique cross-border campus), and at enabling them to develop skills via an efficient mentoring and managerial scheme and (3) helping I-SITE ULNE to achieve its main goal: to be ranked among Europe's 50 leading reference universities and to be recognized at the highest international level. Meeting European standards for doctoral studies, PEARL aims to welcome and guide recruited PhD students in the best conditions, provide them with a secure and unparalleled environment to carry out their research. The selected scientific domains proposed by PEARL combine science and scientific solutions with societal approaches to build tomorrow’s inclusive society promoting citizen well-being, aiming at transferring fundamental discoveries to applied technologies, to produce tangible innovation in society. PEARL will offer top quality conditions and a highly attractive environment of excellence, intended to fuel student’s desire to learn, as well as boost their taste for entrepreneurship and, creativity in research. The interdisciplinary / transnational character of the PhD projects, along with international and inter-sectorial secondments will be an asset for the future employability of PhD students both in and outside academia.


Participants :
- I-site ulne (initiative science - innovation - territoires economie, universite lille nord europe) (France) — Partner, beneficiary, Autres, subvention : 0.0 €
- Université de Lille (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 2440800.0 €
Projet PI3K MODULATORS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

PI3K signalling is a critical regulator of many cellular functions including cell growth and survival, and is deregulated in cancer and auto-immunity. This proposal is based on the concept to cause cell death by hyperactivating signalling in cancer cells above a tolerable threshold. This idea has been previously proposed for other kinases, but no small-molecule activators were available to formally test the idea. This proposal focuses on activators of the leukocyte-enriched PI3Kd, an isoform of PI3K that is involved in immune regulation and haematological malignancies. The 3 key objectives and their approaches are: 1. To discover and characterise small-molecule PI3Kd activators. This will be achieved using a combination of virtual screening and high throughput screening. 2. To understand the mechanism of PI3Kd activation. This enables understanding of how these activators function, and provides structural data that can be used for structure-based design and compound improvement. This will be achieved using structural biology (HDX-MS and crystallography), biochemical (lipid kinase) and biophysical (binding) assays. 3. To determine the activity of PI3Kd activators in haematopoietic malignancies. In order to use PI3Kd activators in cancer therapy, it is critical to determine the conditions under which hyperactivation of PI3Kd results in cancer cell death. This will be achieved with a panel of B and T-cell lymphoma cell lines using cell viability assays under different conditions. These objectives integrate my expertise in compound screening, molecular modelling and compound design with the world-leading expertise of the Host Lab in PI3K signalling, cancer biology and drug development. This proposal aims to make breakthroughs in understanding PI3K signalling, its exploitation in drug development and in cancer-therapy. This will be a key turning point in my scientific career and facilitate PI3K drug development collaborations of the Host Lab with the pharmaceutica.


Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet PI3K-in-tolerance (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

PI3Ks controls important biological processes immunity controlling vesicular trafficking and cell signaling events triggered by pathogen recognition receptors (PRRs). The engagement of PRRs leading to DC antigen processing and presentation (APP) is essential for the bridge between innate and adaptive immunity. Thus, DCs are crucial for resistance against pathogens, while concurrently maintaining tolerance to the commensal microbiota and environmental antigens. Crohn’s disease (CD)-like pathology has been documented in patients with chronic granulomatous disease (CGD), originating from mutations in genes encoding NADPH oxidase (NOX2) subunits or RAC2 GTPase. Both PRR-activated NOX2 and RAC2 are critical for inducing phagosomal reactive oxygen species (ROS) linked to APP processes in the DC. Thus, that dysregulated PRR signalling and NOX2 activity in the DC phagosome, may be key steps involved in some of the pathology observed in CD. The PRR family member NOD2 senses muramyl dipeptide in bacteria. NOD2 was the first susceptibility gene identified for CD and associated with tolerance mechanisms mediating intestinal homeostasis to gut microbiota. Recently, interactions between NOD2 and microbiome were shown to stimulate Treg activity at the mucosal sites. Bacteria-derived outer membrane vesicles (OMVs) from gut commensal Bacteriodes fragilis induce mucosal tolerance by DC-intrinsic activation of NOD2 and enabling DCs to induce IL10 production from Tregs. It is known that OMVs require NOX2-induced ROS to be released for APP and presented by MHCII to activate CD4 Tregs. Our preliminary data shows that mice inactivated in the kinase domain of PI3K delta spontaneously develop colitis in the presence of an intestinal opportunistic pathogens and show defects in antigen presentation in DCs in vitro. Based on these results, I propose to investigate the DC-intrinsic PI3K role in APP functions that control gut tolerance in this animal model of colitis.

Mots clés : pi3k, immune tolerance, immune regulation, colitis, nod2

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet PLANAFFHO (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

PLANAFFHO - PLANning for AFFordable HOusing, aims to examine how land-use planning has contributed to the provision of affordable housing for low-income people and has promoted a mix of housing tenures within new developments in three capital cities - Copenhagen, Lisbon, and London, over the last ten years. The first aim and principal focus of the research is therefore investigating planning and housing activities in three cities (Copenhagen, Lisbon and London) that seek to address problems of housing shortage, affordability, and segregation of housing tenures. The research aims to provide practical knowledge and innovative advice to decision-makers on what can be done regarding these huge societal challenges. The second aim of the research, underpinning and informing the former, is to make a contribution to the theoretical and methodological advancement of international comparative research on housing and land-use planning. In order to meet these aims, the theoretical and methodological skills of the candidate will be strengthened at the Cambridge Centre for Housing and Planning Research, located within the Department of Land Economy, University of Cambridge, and led by Professor Michael Oxley. With over 25 years of experience and a proven track record of providing evidence and analysis to influence and support better policy and practice in several areas, the Centre is well-placed to broaden her practical experience of housing and planning matters, from both an interdisciplinary and a comparative perspective. The research will involve short-term visits to planning departments and non-profit housing associations in Copenhagen, Lisbon, and London, aiming to contribute to a mutual exchange of knowledge. During the visits, the candidate will collect data and conduct fieldwork. The data will be analysed though the lens of spatial and social scrutiny, an optic with which an ER with a background in geography, spatial planning, and sociology is already familiar.

Mots clés : comparative international research, housing policies, land use planning, affordable housing, housing shortage, segregation

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet POLONEZ BIS (Horizon 2020, appel à projets 2019)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

POLONEZ BIS is a postdoctoral Fellowship Programme addressed to excellent experienced researchers interested in developing their professional skills within the stimulating environment of best research institutions in Poland. Open to candidates of any research background, discipline or nationality, the programme plans to recruit 120 scientists with a PhD degree or equivalent research experience, in 3 globally advertised calls. Selected in a transparent, merit-based evaluation process based on international peer-review, the fellows will be offered 2-year full-time employment contracts to work on projects combining basic research with a cross-sectoral secondment phase. Fellows will be independent in designing their own career development plan and will collaborate with outstanding supervisors at an academic or non-academic host institution of their choice. The programme guarantees excellent working conditions inclusive of a generous salary (€ 53,5 K a year, gross), an annual research grant (€ 50 K) and a comprehensive Research Leaders’ Training Programme enhancing both research-related and transferable skills. POLONEZ BIS will be managed by the National Science Centre (NCN), a government agency with over 8-years of experience in funding curiosity-driven research in Poland. To strengthen the programme’s impact, NCN will involve 4 project partner organisations: Careers Research and Advisory Centre to reinforce the fellows’ potential for professional development, Startup HUB Poland to provide insight into the non-academic sector and match fellows with appropriate secondment institutions, Polish Women Scientists Network to conduct Responsible Research and Innovation training as well as support fellows in communication of research results to the general public and the Interdisciplinary Center for Mathematical and Computational Modelling to advise on the choice of appropriate Open Access and Open Data tools to disseminate research results to the scientific community.

Mots clés : international mobility, curiosity driven research, cross sectoral experience, transferable skills, networking, financial independence, postdoctoral fellowship, experienced researcher, poland

Participants :
- National Science Center (Pologne) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 8827200.0 €
Projet PRECALI (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

PREeclampsia risk stratification test: development of CALIbration framework for the analysis of a multiplex panel of endogenous Compounds by LC-MS. Metabolomic Diagnostics (MDx) is an innovative company which is developing tests for pre-eclampsia in pregnancy. MDx consists of a team of scientists and entrepreneurs with clinical support. The enterprise and the experienced researcher propose to combine their expertise to support the development of a robust test for the risk stratification of preeclampsia. One of the key challenges in the product development is establishing the optimal way to perform the quantification of the metabolite targets underpinning the preeclmapsia test. In the case of risk stratification products, the predictive metabolite biomarker profiles are merely a perturbation in the levels of a set of endogenous occurring metabolites. As a result, the internationally well-established LC-MS test validation framework as known for bioanalysis is not readily applicable. The researcher’s doctoral dissertation focused on the development and subsequent validation of novel mass spectrometric assays for endogenous metabolites and she explored a novel validation strategy to overcome the limitations of the classic bioanalysis validation framework with regards to validation mass spectrometric assays for endogenous compounds. It would be difficult for MDx to find a candidate with a more relevant background for this project and it would be equally difficult for the researcher to find a company in Europe with such a perfect project to implement her expertise extensively. The scope of this project is the development of an appropriate quantification strategy for the product, with the following prerequisites: - 1. Delivering robust quantification data which can be fed to the product risk stratification algorithm - 2. Delivering robust quantification data in a format which can be accepted by key stakeholders

Mots clés : metabolomics, biomarkers, pregnancy, preeclampsia, risk stratification, personalised medicine

Participants :
- Metabolomic diagnostics limited (Irlande) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 175866.0 €