Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MiTuMi (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Lung cancer is the leading cause of cancer-related mortality in the world. It most often gets diagnosed at an advanced stage with a 5-year survival rate as low as 5%. Despite recent advances in development of therapeutics, lack of a comprehensive understanding of the complexity and dynamicity of the tumor microenvironment hinders effective clinical outcome. Tumor microenvironment plays a crucial role in tumorigenesis and subsequent disease progression leading to metastasis as well as resistance to therapeutics. Conventional monolayer culturing of tumor cells fails to recapitulate the essential microenvironmental aspects of native tumors whereas mouse models suffer from limited relevance, high cost and low throughput. A three-dimensional (3D) human in vitro tumor model that faithfully mimics the tumor microenvironment is key to advance the current understanding of biological processes and signaling pathways that govern these complex pathological events. I propose a biomimetic human lung tumor model that allows independent tunability and control of aberrant biochemical and mechanical aspects of the tumor microenvironment to study cellular events that govern tumorigenesis (Objective1), metastasis and drug resistance (Objective2) and patient heterogeneity (Objective3). Following a highly interdisciplinary approach where tissue engineering, material science, medicine and molecular biology converges, the implications of a tunable and biomimetic 3D human tumor model is substantial for the future of precision-medicine and development of patient- specific therapeutic regimens.

Mots clés : cancer tissue engineering, biomimetic materials, tumor microenvironment

Participants :
- Koç University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 145355.52 €
Projet LUSO-ZION (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Luso-Zion examines a growing religious tendency in the world, namely the appropriation by charismatic evangelicals/Pentecostals of Jewish narratives, rituals, and even Zionist anxieties. These last have gained international attention in evangelical support for the U.S. administration’s decision to establish an embassy in Jerusalem. At the same time, Brazilian Pentecostals also now demand that far-right President Bolsonaro fulfils his campaign promises to do the same. While this adoption of Jewish liturgy, rituals, and Zionist geopolitical support by charismatic evangelical Christians is becoming more and more evident all over the world, no transnational study in the literature explains this growing tendency. To date, existing scholarship examining this phenomenon overwhelmingly focuses on U.S. cases. Against this backdrop, Luso-Zion aims to elucidate how these religious forms and political leanings are taking shape within the Lusophone context with cases in Angola, Brazil and Portugal. Through an ethnographic and geopolitical transnational comparison, this research investigates this phenomenon across multiple locations to construct a socio-cultural and political narrative that explains why contemporary charismatic evangelical/Pentecostal movements are turning to Judaism and Zionist discourses. This research contributes to a greater socio-cultural understanding of this new religious tendency and indicates the potential implications of these religiously inflicted Zionist attitudes in Lusophone geopolitics. Therefore, Luso-Zion is relevant not only because it is the first study to provide a transnational comparative framework for comprehending this new religious tendency in charismatic evangelicalism/Pentecostalism but also because it informs international relations studies and policymaking on how grassroots religious movements can be impacting contemporary geopolitics in the Lusophone Atlantic.

Mots clés : christian zionism, judaizing groups, faith based diplomacy, charismatic evangelicalism, pentecostalism, lusophone christianities, religion and international relations

Participants :
- École des hautes études en sciences sociales (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Groningen (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 263358.72 €
Projet PerMet (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

MAIN GOAL: To characterize the role of peroxisomal fatty acid oxidation (pFAO) and its relative importance in the differently active endothelial cell (EC) subtypes during blood vessel sprouting (angiogenesis). BACKGROUND & RATIONALE: Activation of ECs by growth factors such as VEGF induces vessel sprouting, requiring a switch from quiescent phalanx ECs to a leading tip EC and proliferating stalk ECs. The host lab recently showed that this angiogenic switch requires a metabolic switch, with specific roles for glycolysis and mitochondrial fatty acid oxidation (FAO). ECs also have peroxisomes, which metabolize very long chain fatty acids (VLCFAs), but nothing is known about the possible role of peroxisomes/pFAO in ECs. Multifunctional protein 2 (MFP2) is the key enzyme of pFAO. Initial data from the host lab indicates that MFP2 silencing in ECs impairs vessel sprouting in vitro. I hypothesize that pFAO regulates the tip/stalk/phalanx EC subtypes differently during sprouting and will examine the underlying (peroxisomal) metabolic mechanisms. METHODOLOGY: I will use a multidisciplinary approach, combining molecular and cellular biology, in vitro and in vivo angiogenesis models, and conditional mouse genetics, to characterize the role of MFP2 in vascular sprouting. I will use scRNA-seq to define the (peroxisomal) metabolic gene signature of the 3 EC subtypes and explore whether MFP2 loss results in population shifts of tip, stalk and phalanx ECs. Furthermore, I will use state-of-the-art metabolomics and 13C tracing to define the metabolic fate of peroxisomally metabolized VLCFAs, with the ultimate goal of evaluating their physiological relevance in ECs. NOVELTY AND TRANSLATIONAL IMPACT: The data promise first insights in pFAO’s role in vessel sprouting and the first (peroxisomal) metabolic gene signature of tip, stalk & phalanx EC subtypes at single cell level, and may identify pFAO genes as potential novel targets in strategies to inhibit pathological angiogenesis.

Mots clés : angiogenesis, tip and stalk cells, peroxisomes and endothelial cells

Participants :
- Vlaams Instituut voor Biotechnologie (Belgique) — Coordinator, beneficiary, Recherche, subvention : 160800.0 €
Projet MEDMOTILUS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

MEDMOTILUS aims to uncover the alterations of gut mucus/microbiota homeostasis in metabolic diseases and therapeutic targets using human data and animal models. It will fill research gaps in the multiple scenarios of metabolic diseases, one of the greatest threats to human health. The gut microbiota is a key environmental factor of these diseases, and its modulation is a potential treatment. However, the host-microbiota interactions are far from being fully described. The gut mucus barrier is a host spatial control that plays a crucial role in the microbiota regulation but poorly understood. Diet and medicines may affect this defense and, thus, improving metabolism and reducing gut bacterial motility, whose increase is linked to health disorders even without serious infections. However, there is no in-depth bacterial motility characterization in metabolic diseases and no data on mucus features nor on its effect on bacteria in these diseases. So, the overall research goal of MEDMOTILUS is to provide evidence of the impact of gut bacterial motility and mucus in metabolic diseases as key factors involving dysbiosis, mucus features, and metabolic status. MEDMOTILUS takes a multidisciplinary approach. It will go beyond the current state-of-the-art by using original input data (bacterial motility from modeling and mucus features) with multi-omic approaches (also metabolomics and metagenomics). Several potential solutions acting on mucus will be assessed in mice. The use of human data already generated and animal models (mice and a new pig model) will allow me to identify robust and useful biomarkers of the gut mucus/microbiota homeostasis in metabolic diseases for further research on diagnosis and monitoring to reduce long-term complications and deaths. At the level of my career, MEDMOTILUS will allow me to enhance my research profile and network, strongly impacting my chances of achieving my long-term goal to become a Professor and develop a prolific scientific career.

Mots clés : animal model, bacterial motility, integrative analysis, metabolic diseases, metagenomics, microbiome, microbiota, mouse, mucus barrier, multi omics, obesity, type 2 diabetes mellitus

Participants :
- Sorbonne Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €
Projet MOBILESITES (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

MOBILESITES comprises my ‘mobility’ training programme for the next three years and my research project, entitled ‘Mobilising Mecca, Medina, and Jerusalem: Representations of the Islamic Holy Sites in the Ottoman Empire’. This training programme would immensely improve my career development through a reciprocal transfer of knowledge, and this research project would provide me with time and resources to expand and amplify a chapter and certain sections of my doctoral dissertation into a scholarly book. Furthermore, the MSCA-IF-GF would help me build upon my teaching and research experience by working at outstanding institutions and with prominent supervisors. During the outgoing phase of the MSCA-IF-GF, I will spend 24 months at the University of Michigan’s (U-M) Department of History of Art under the supervision of Prof. Dr Christiane Gruber. During the incoming phase, I will spend 12 months at Universität Hamburg’s (UHH) Asien-Afrika-Institut, Geschichte und Kultur des Vorderen Orients under the supervision of Prof. Dr Stefan Heidemann. Furthermore, the Museum für Islamische Kunst in Berlin (ISL) and Prof. Dr Stefan Weber will host my intersectoral secondment during months 22–24. The three work packages (summarised in the Gantt Chart), Towards Publications (WP1), Towards Teaching (WP2), and Towards Curating (WP3), make up my distinct yet related three-year action plan. WP1 not only includes the work required for my book project but also the research and preparation for conference/symposium presentations, peer-reviewed articles, and workshops. WP2 consists of the preparations for lectures and active teaching itself, as well as improving my e-teaching, linguistic, codicological, and epigraphic skills. And finally, WP3 covers the curatorial training that I would like to gain in a museum environment and converting my research into displays and content that are accessible to a larger public.

Mots clés : image and image and text and image relations, functional diversity, media change, islamic pilgrimage and visitation

Participants :
- University of Michigan–Ann Arbor (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Universität Hamburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 246669.12 €
Projet Montenight2020 (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

MONTENIGHT 2020 "IMAGINE FUTURE" has an aim to upgrade the image of researchers, novel technologies, and innovations, addressing their important role for the prospective of our society in Modern Era. The project will demonstrate the "human face" of R&I by clarifying practical benefits and impact on everyday life and motivate youth to pursue science studies and careers. The project will promote a knowledge-based society by emphasizing R&I in competitive sectors (ICT technologies, researches in the field of energy and sustainable environment, sustainable and health tourism and sustainable agriculture and food, as well as other relevant fields to build up Montenegro as a healthy, sustainable and digital society), while activities program will include MSC fellows for the first time. The events will be staged in the Montenegrin capital Podgorica (universities, museums, galleries, shopping malls, main squares) and in 8 more cities, while 10 pre-events smaller scale science Festivals would be held in all three regions. RN activities involve Open Science Show, 300 hands-on experiments, robot performances, Science and Art installations, Science Cafe, Quiz, student science and innovation competitions, Concert, Movie projections, Interdisciplinary workshops, friendly events for kids - Science Cooking, Science kindergarten, Funny Math ... Our target audiences are high school & university students, preschool and elementary school children, parents, school administrators, teachers, researchers, general public, and media. At least 5000 of them would be directly involved, and up to 50% of the population would be reached via media advertising. The pan-European values will be disseminated through EU Corners, public tribunes, and panels, introducing researchers who benefit from EU support.

Mots clés : sustainable environment and energy, sustainable agriculture, sustainable tourism in general, as well as health tourism and the innovation

Participants :
- Prirodnjacki Muzej Crne Gore (Monténégro) — Coordinator, beneficiary, Recherche, subvention : 9347.5 €
- Fondacija za promovisanje nauke "prona" (Monténégro) — Partner, beneficiary, Autres, subvention : 36674.0 €
Projet MUSICA (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

MUSICA will orchestrate an MSC-Action where the deepening of our knowledge of the local Universe will play together with unveiling the cosmic dawn. We will focus on the origin of new structures, stains, in the diffuse Galactic interstellar medium (ISM) recently revealed by the LOFAR radio telescope and model their contamination to the observations of the Epoch of Reionization. The study of the diffuse ISM is key for pivotal astrophysical problems, such as the inefficiency of the star formation process. The ISM fills the Galaxy with cosmic rays, multiphase gas, and dust particles, all coupled with magnetic fields. It is through their interactions that a complex cycle, involving phase transitions, magneto-hydrodynamic (MHD) turbulence, and gravity, is expected to convert diffuse/warm matter into denser/colder regions, where stars form at a rate of only a few solar masses per year. In theory, magnetic fields in the ISM may explain such low star-formation rate. In practice, characterizing magnetism at the starting point of this cycle of matter has been a difficult observational challenge until now. Today, the Planck satellite and LOFAR are unique complementary datasets to investigate phase transition between warm/ionized and atomic magnetized ISM. MUSICA proposes an unprecedented joint analysis of the Planck/LOFAR data with the best-available kinematic data of the atomic and ionized hydrogen to investigate the MHD origin of the stains. By comparing observations with synthetic data from state-of-the-art MHD simulations of the ISM, MUSICA will (1) significantly advance our knowledge of structure formation in the diffuse ISM and (2) prepare foreground analyses for future cosmological probes, such as LOFAR and the SKA radio telescopes. Hence, funding MUSICA will allow partners to (i) start a scientific network across Europe (France/Croatia) in line with the H2020 priorities, (ii) do science on the front line and (iii) secure their research in novel international projects.

Mots clés : galactic magnetic field, faraday tomography, dust polarisation, early phases of star, formation, magnetohydrodynamics, galactic foregrounds for cosmological 21cm experiments

Participants :
- Rudjer Boskovic Institute (Croatie) — Coordinator, beneficiary, Recherche, subvention : 147463.68 €
Projet MYRiCE (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

MYR<i>CE aims at contributing to the study of the cultural history of Byzantium and the dissemination of its memory across the centuries, by considering a major monument – the church of the Holy Apostles at Constantinople – and the symbolism associated to it. The objective of the research is to understand the reason why this monument occupies a crucial place in Byzantine and Mediaeval times. To seize the specific status of this monument, I will run an investigation into a set of sources referring to it (textual, iconographic) and follow the paths of its dissemination across time and space. My twofold training in philology and art history will be essential for the analysis of the material relevant to the case and for the successful accomplishment of MYR<i>CE. For the first time, the enforced analysis will treat the monument as a historical element, inserted in the process of cultural transmission, thus giving a significant contribution to shifting traditional scholarly focus away from the mere consideration of its architectural forms. The methodology adopted will promote cultural historical modes of investigation, opening new avenues of research for the field. Given the importance of the example chosen, this project is potentially entitled to become a reference model for other comparable case-studies. MYR<i>CE comes appropriately timed, in a moment in which the monument is drawing again scholarly attention. The mobility plan proposed will allow training at EPHE to acquire the methods of questioning textual and visual material from an historical and anthropological perspective, in order to understand the topic proposed in its cultural specificity, and residence at UNIVE in order to develop the hermeneutical part of the study and to access textual and monumental sources (San Marco) relevant to the case. The action will let me benefit from interaction with an international network of excellence, in compliance with the goals set within the ERA framework.

Mots clés : migration of myths, symbols, ideas, cultural memory of byzantium in the, mediaeval west

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet MaMo (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

MaMo is a research project that focuses on Socialist rural architecture and landscape and its Post-socialist legacy in the Albanian countryside, aiming at (1) investigating how the communist ideology materialized in the Albanian rural territorial and architectural planning; (2) analysing the current condition of the former agricultural cooperatives and state farms settlements and how they relate with the compelling informal post-socialist transformation; (3) proposing a multi-level and interlaced understanding of Socialist modernism and its contemporary transformation through local rural communities perceptions and experiences. Further, by producing a novel scientific contribution in the academic research fields of contemporary ethnography and anthropology, modern architecture and landscape planning and history, and critical cultural heritage studies, MaMo intends (4) to constitute a national and international platform to discuss and place for the first time Albania in the framework of European studies on modernist rural architecture and landscape. In fact, as for many European states during the 20th-century, Socialist Albania planned, adopted and implemented large scale development and agricultural plans to modernize its rural areas. Crucial to the nation and state-building policies, those plans provided a trial opportunity for new landscape and architecture ideas converging on the vision imposed by the regime. Through a multidisciplinary research-through-training approach based on the collection, processing, and critical interpretation of visual data and multiple narratives, MaMo will systematically explore and document for the first time the Socialist modern rural architecture and its Post-socialist legacies in the Albanian countryside.

Mots clés : socialist modernization processes, rural architecture and landscape, collective cooperatives and state farms, rural communities, urbanization, socialist legacy, post socialist evidence, albania

Participants :
- Akademia e Studimeve Albanologjike (Albanie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 137679.36 €
Projet MACARONIGHT 2021 (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

Macaronesia is a biogeographical region of five archipelagos in the Atlantic Ocean of which four are inhabited: Azores (Portugal), Canarias (Spain), Madeira (Portugal) and Cape Verde (Cabo Verde). These islands share common geographical traits and similar challenges with regards to climate change, environmental degradation and loss of biodiversity. The Canary Islands, Madeira and the Azores are part of the European Union (EU Outermost Regions). The overall objective of this project is to organise a shared Researchers' Night for the Macaronesia Region for the fourth consecutive year connecting the population of these remote islands under the umbrella of the universal language of science. This new edition, MACARONIGHT 2021 aims at further widening public awareness towards science, research and innovation, especially in areas where the Region faces global challenges, such as those identified in the European Green Deal. The aim is to reach out to the population in general yet keeping specific focus on teenagers and young parents with kids in particular. The project will deploy an enhanced social-media strategy that aims to engage with citizens of different ages in their own words through their daily used channels. Activities will cover 16 islands with the "main" activities organised at 4 locations: Tenerife (La Laguna), Gran Canaria (Las Palmas), Madeira (Funchal), Azores (Ponta Delgada). The programmes will be organised as "hybrid" online/physical events that will attract 30 thousand participants in total. We expect that the introduction of the Green Deal topic for 2021 will be translated into active change in the region's compliance with Green Deal objectives and the overall vision described by Climate KIC's strategy, "Transformation in Time".

Mots clés : outermost regions, green deal, living labs, biodiversity, climate impact, remote regions

Participants :
- Regional Secretariat for the Sea, Science and Technology (Portugal) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 70147.0 €
- University of La Laguna (Espagne) — Partner, beneficiary, Autres, subvention : 49427.0 €
- University of Las Palmas de Gran Canaria (Espagne) — Partner, beneficiary, Recherche, subvention : 42739.13 €
- Universidade da Madeira (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 34232.0 €
- La Palma Research Centre for Future Studies (Espagne) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 59015.9 €