Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet NeuroExcell (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

NeuroExcell aims to reveal physiological roles of the ECS structure and dynamics in directly regulating neuronal signalling, by taking advantage of the innovative new Super-resolution Shadow Imaging (SUSHI) technique. It will elucidate the nanoscale structure of the ECS of entire mouse brain hemispheres at different planes of the brain. Inherently, it will reveal simultaneously all cells as analyzable shadows what will provide unprecedented ECS maps, to complement general existing cellular maps. The results will further clarify the distribution and duration of structural ECS dynamics across areas, and will disclose the relation between ECS structure, dynamics and protein distribution in the extracellular matrix. Investigating this in live tissue slices will further allow direct visualization and analysis of diffusional processes what will help to disclose the physiological roles of the ECS. The fundamental nature of the results, and the advanced technological framework, will be of fundamental interest for neurophysiologists, glia cell biologists, and glymphatic system researchers, among others. NeuroExcell will be carried out in a multidisciplinary environment involving advanced fluorescence imaging methods, classic electrophysiological techniques, computational modelling, biophysical theory and biochemistry. For the project I will join an emerging neuroscience institute where I will further enhance and diversify my professional competences through advanced training and quality research, adding to my development toward becoming an independent research group leader.

Mots clés : brain extracellular space neuronal signaling extrasynaptic signaling microglia sted super resolution optogenetics

Participants :
- Gouvernement basque (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université du Pays basque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet WaninGreek (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

During Antiquity, Sicily was a part of Magna Graecia and was still a hub of Greek civilisation under the Byzantine Empire. After being taken over by the Arabs (9th c.) and then by the Normans (11th c.), Greek culture continued to thrive. However, by 1200, Sicily had undergone a near-complete Latinisation. What caused this cultural shift to occur? Despite the significant impact of the Norman Conquest and immigration from the Continent, the waning of Greek society was primarily caused by the establishment of the Latin Church. While most narrative sources overlook this major transition, the best evidence can be found in documentary sources. Although Latin charters, which primarily focus on the royal government, have been studied, it is important to also explore Greek charters, the richest source of the day-to-day processes that transformed Sicilian society. The diocesan archive of Patti (prov. of Messina) provides valuable insights into this historical transformation. In the late 11th and 12th centuries, Patti lay on the cultural frontier between the predominantly Greek northeast of Sicily and the heavily Arabised west and centre. Despite Islamic rule, a few Greek monasteries managed to survive. When the Normans took over, the Greek Church experienced a resurgence and Greek was the mostly used administrative language. However, when Sicily passed to Henry VI in 1194 and Latin became the sole language of administration, Greek culture was already in decline. WaninGreek studies the Latin Church’s role in the transition of Greek communities. I plan to produce a reference edition of the Greek charters of Patti and to use the Latin archives to produce a historical monograph. My goal is to make these sources accessible to future scholars and to provide an enlarged and detailed account of the process. Starting from a local level, I will demonstrate how cultural changes occurred during the Middle Ages and how this approach can enrich the history of the entire Mediterranean area.

Mots clés : mediterranean sea multiculturalism multilingualism norman sicily byzantine sicily arabic sicily byzantine greek medieval latin palaeography

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet HotPasserine (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Our ability to quantify and predict the magnitude of environmental global changes effects represents one of the major challenges of the 21st century. These changes are characterised by a a gradual increase of ambient temperature through time, but also leading to an increased frequency of climate anomalies, such as heat waves. Habitat urbanisation, in particular, is a key driver of the increase of ambient temperature. These temperature changes can drastically modify the phenology of species, their geographic distribution, food webs, interspecific interactions, but also life history trajectories, behaviour and physiology of individuals. Yet endotherms capacities to adapt to thermal stress remain poorly understood. The aim of this project is to evaluate the harmful repercussions of thermal stress on the physiology of organisms, and on their life history trajectories (reproduction and survival). Using a multidisciplinary and integrative approach, I plan to conduct two experiments on Great tits to assess the effects of thermal stress on different molecular and physiological mechanisms (metabolic rates, mitochondrial function, markers of ageing, stress, Hsp expression) by manipulating temperature (increase, decrease, mis-match) under common garden conditions, during development and growth period and follow various life history traits such as growth and survival patterns. This project will provide exceptional insights to characterise variation of individuals’ life history trajectories and physiological responses to thermal stress and unusually warm temperatures; such results will be key to pinpoint the mechanisms linking thermal changes to any potential effects on life-history trajectories, which is crucial to monitor organisms’ responses to climate change. We hope that this work will help to assess the fitness prospects of wild animals and potentially to predict extinction risks of animal populations in the context of global changes.

Mots clés : thermal stress, body temperature, life history trajectories, metabolism, physiology, behaviour, stress, ageing, birds, climate change

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet LiquidWallCat (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Flow reactors offer benefits over batch reactions, such as precise control over conditions and high turnover numbers of catalysts through immobilization in packed beds. However, the small dimensions of the flow reactor lead to increased friction between solvent and reactor wall, which causes loss in efficiency. In addition, flow systems are vulnerable to reagents that may foul or clog the system. The host group recently developed microfluidic tubes with ferrofluid walls. The walls are kept in place by a quadrupolar arrangement of magnets, while their liquid nature diminishes the friction at the interface and prevents particles from clogging the system by temporarily expanding the microtube when necessary. In this project, I intend to improve on this system by embedding well-established catalysts immobilized on magnetite nanoparticles into the ferrofluid. This will allow us to achieve the high turnover numbers that are common for flow reactors containing immobilized catalysts, while benefiting from the low-friction and anti-clogging properties of the liquid wall tubes. In addition, I will perform mechanistic analysis of the newly developed flow reactions in liquid wall tubes. This will aid the broader scientific community to further expand the utility of this new technology. As such, the project promises important improvements in the field of flow chemistry. The highly interdisciplinary nature of the project allows me to fully apply my expertise in the field of catalysis, while benefiting from knowledge transfer in microfluidics, in which the host research group has an expertise.

Mots clés : flow chemistry, microfluidics, magnetic nanoparticles

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 123984.72 €
Projet OPERAS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Ultra-compact sensors that can detect single nanoscale objects are presently highly desirable. However, state-of-the-art sensors lack selectivity and the concurrent detection of multiple analytes. Thus, OPERAS seeks to build an enhanced class of highly selective and sensitive fiber-tip sensors based on nanophotonics and plasmonics that can be easily multiplexed. Its distinctiveness stems from the introduction of quantum perturbation method (QPM) for nanoparticles' susceptibilities, full vector beam propagation method (FVBPM) for fiber sensor optimization, and gold nanoparticles immobilization protocol on the end facet of an optical fiber to fabricate the sensing probe. These methods are not only reproducible but also allow real-time monitoring of the fabrication process, making batch sensor fabrication feasible. With the combination of optical phenomena at the nanoscale, optical fiber technology, and advanced simulation based on the QPM and FVBPM, OPERAS seeks to create synergistic nanospectroscopic sensors for uses in a variety of fields. The fabricated sensors will be tested for the detection of nanoplastics and heavy metals in water at concentrations as low as nanograms per liter. Other applications including disease diagnosis and environmental monitoring are also foreseen. Although the sensor has good selectivity and hypersensitivity due to the QPM and FVBPM, its implementation through the use of an optical fiber makes the sensor compact, safe to use, and easy to interrogate. This creative and well-organized project will undoubtedly yield numerous important research outputs that will further our understanding of the exposure of people to nano objects, highlight and support European research in this area, help establish an affordable sensing technology, and improve environmental and healthcare monitoring. Unquestionably, OPERAS is expected to bring a breakthrough in optical sensor technology and contribute to the development of new sensing technology in Europe.

Mots clés : optical fibers, nanomaterial on fiber tip, quantum perturbation method, full vector beam propagation method, optical sensing

Participants :
- Université du Pays basque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €
- Université de technologie d'Eindhoven (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- UK Research and Innovation (Royaume-Uni) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet CRMS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Chirality is an essential property of nature, producing and regulating fundamental phenomena in living matter. Chiral compounds are widely used in medicine, clinical, pathological, and other fields. Different enantiomers of chiral molecules have significant differences in pharmacological activities, metabolic effects, toxicity, and even opposite effects. Since most chiral compounds exist in the racemic form, it is important to develop strategies for rapid and efficient separation and purification of chiral compounds to deal with inevitable future threats such as diseases and viruses. Although many techniques for chiral resolutions have been developed over the years, most of them are impeded by low efficiency and accuracy, high energy consumption, tedious preparation and operation and high cost. Therefore, I propose a project, CRMS “Chiral Resolution using Microfluidics and helical Supramolecular polymers” which aims to develop a simple diffusion-based strategy for chiral resolution by incorporating helical supramolecular polymers (HSPs). In this project, I will combine the ability of HSPs to recognize the handedness of chiral molecules through non-covalent interactions with the diffusion-based separation ability of microfluidics for the enantio-separation of chiral molecules. I chose microfluidics for chiral resolution because it is a cost-effective and energy-efficient technique that takes advantage of the natural flow properties of the fluids entering the flow reactor for diffusion-based separation. CRMS project will not only start a new area of research in the junction of supramolecular chirality and flow chemistry but also have applications in pharmaceutical and cosmetic industries for enantio-separation of chiral drugs/ingredients.

Mots clés : supramolecular polymers, helical supramolecular polymers, microfluidics, flow chemistry, chiral resolution, enantioseparation, diffusion based separation, racemic mixture

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 128316.68 €
Projet STED (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The STED project aims at giving an important push to the scientific career of the applicant, in a timely and interdisciplinary topic: imaging the early stages of quantum motion of electrons at their natural space-time scales, i.e., with picometer and attosecond/femtosecond resolutions. The project will take place at IMDEA Nanoscience, a leading multidisciplinary research center dedicated to nanoscience and the development of nanotechnology applications in connection with innovative industries.  Electron motion in molecular systems is responsible for natural processes such as photosynthesis, photooxidation, or electronic transport. It is also at the heart of novel technologies based on photovoltaic devices, artificial photosynthesis, molecular wires, etc. Understanding the underlying electron dynamics demands investigating these processes at their natural spatial and temporal scales. In the STED project, I will build a setup where a CW laser and few-femtosecond long laser pulses will be combined with a low-temperature STM. This setup will allow me to image and eventually control electron dynamics occurring in different molecular systems deposited on solid substrates at electronic time scales from hundreds of attoseconds to a few femtoseconds, with simultaneous sub-molecular spatial resolution. I will focus on investigating Rabi oscillations of individual phthalocyanine molecules, and charge-transfer processes between a donor and an acceptor phthalocyanine. The goals are to spectroscopically characterize the induced electron dynamics in real space with the CW laser, and subsequently provide the 'film' of the distribution of the electronic density in real time and real space with the pulsed laser source. This will allow me, e.g., to understand the origin of early sources of decoherences that reduce the efficiency of electronic transport, with possible implications in photovoltaics and quantum information technologies.

Mots clés : ultrafast electron dynamics, ultrafast scanning tunneling microscopy, space time imaging, ultrafast charge transfer, cw laser, rabi splitting, rabi oscillations

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet MIA (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The growing field of extended reality (XR) has shown how technology can expand the physical world with real-time digital information and interactions through applications spanning from hybrid meetings to assisted hearing. While plausible visual information is easily delivered, when not adapted to each user, generic sound rendering lacks realism, increases cognitive load and limits accessibility. Still, a recent study found that only 97% of analysed applications ignore personalised sound rendering due to its complex acoustic requirements. MIA (Modelling Individual Acoustics for plausible extended realities) aims at individualising audio rendering by developing a widely adoptable solution that leverages advancements in psychoacoustics and explainable artificial intelligence (AI). The proposed research effort will (1) explore and determine requirements across multiple acoustic contexts, (2) prototype an explainable AI model to infer individual audio characteristics, and (3) implement a personalisation procedure based on user actions to guarantee plausibility over specific contexts. The resulting software solution aims to provide a toolkit with minimal hardware requirements to integrate plausible audio in XR applications. MIA will foster open-science practices while exploring protection measures for EU product development, supporting the EU's goals of advancing technological innovation and enhancing digital inclusion, particularly in remote work, education, and hearing assistance technologies. To succeed, MIA integrates the diverse fields of expertise of the researcher on auditory modelling and advanced Bayesian statistics, of the host institution on audio-signal processing and XR applications, and of the secondment host on the development of explainable AI. The researcher will, therefore, have the chance to collaborate with multiple leading experts to expand his expertise and professional networks, supporting his development for an independent career.

Mots clés : extended reality, spatial audio, hrtf, probabilistic modelling, user modelling

Participants :
- Université de technologie d'Eindhoven (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet TIPPING-RIVERS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Peak water describes the point in time beyond which glacier and snow melt irreversibly reduce. It is widely seen as a tipping point at which hydrological processes in glacierized catchments are forever altered and water security is put increasingly at risk. Through TIPPING-RIVERS, I will systematically quantify the impact of the point in time beyond which glacier and snow melt irreversibly reduce peak water on water security. Using a comprehensive risk assessment approach (risk = hazard x exposure x vulnerability), I will quantify the risk of a ‘tipping’ from a water secure to an insecure region in two case study catchments. Given my background in hydrology, I will put a strong focus on the hazard-component, identifying ecohydrological catchment characteristics which accelerate, delay or hinder negative impacts of melt water loss. To translate the natural hazard into risk for society, I will combine the hydrological analysis with the assessment of the exposure as well as the vulnerability of downstream communities. The assessment of local tipping points conducted in this project, will be based on the planetary boundaries framework. Its use for the identification of local boundaries has thus far been limited but highly demanded to better anticipate and prevent irreversible and adverse changes to the environment. TIPPING-RIVERS will advance the science in this field by developing a framework for local freshwater boundary assessments.

Mots clés : peak water, tipping points, water security, freshwater boundary framework

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet eShapeUltracold (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

One of the most puzzling observations in contemporary physics is the striking imbalance of matter over antimatter in our Universe. The Standard Model of Particle Physics predicts that nearly equal amounts of matter and antimatter should have been created, but all the antimatter seems to have disappeared. This discrepancy could be explained by a new particle or interaction that breaks the symmetry between matter and antimatter. Many different experiments are looking for signatures of this broken symmetry (CP violation) using a wide variety of particles, atoms and molecules. The CP-violating signature this project focuses on is an asymmetry in the shape of the electron, quantified by its electric dipole moment (EDM). The aim is to measure the EDM of the electron with tenfold better precision compared to the current state-of-the-art experiments. Such an unprecedented sensitivity can be achieved by using ultra-cold molecules instead of cold molecules, their slower speeds increasing the time spent in the sensitive region of experimental apparatus. However, the longer interrogation times bring new challenges regarding experimental stability and systematic effects. The objectives of this project are to use my expertise in magnetic field optimisation and high-precision experiments to tackle these challenges and to collect and carefully analyse the electron EDM data, testing predictions of new physics. This fellowship would give me the opportunity to learn how to create, control and detect ultra-cold molecules from the world-leading experts at Imperial College, and the curated training programme will allow me to grow into an independent researcher capable of leading my own research group. These skills are crucial in the next stage of my career as I want to continue with these tabletop experiments with molecules for fundamental physics, probing for new physics beyond the energy range accessible by the accelerator-based experiments such as at the LHC.

Mots clés : electric dipole moment, fundamental symmetries, cp violation, magnetic field stability, high precision experiment

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €