Projet NERVSPAN (Horizon Europe, appel à projets 2022)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

The objective of this network is to train, through research, a group of 10 young scientists, giving them the practical skills and knowledge necessary to tackleThe function of a neuron is determined by its expression of morphogen receptors and adhesion proteins (to pattern its connectome), of synaptic protein complexes (for intercellular communication), and of ion channels (for neuronal excitability and signal propagation). The protein composition of any neuron is itself dependent on gene expression controlled by transcription factors and by post-transcriptional regulations (splicing, translation, protein stability). Finally, neurons are highly compartmentalized cells and require trafficking of proteins to their correct locations. Alterations of these neuronal features can therefore be observed at multiple levels: molecular, cellular, and behavioral. We will focus on three neuronal features: i) gene expression levels as measured by RNA sequencing and proteomics, ii) assembly of functional multiprotein complexes (by high resolution microscopy and proximity dependent protein labelling), and iii) phenotypic output via a combination of optogenetics, calcium imaging, and behavioral assays. This research program will help define the critical features that differentiate between physiological and pathological states of a given neuron. Such biomarkers would be precious to facilitate drug screens or develop novel therapeutic strategies for human neurological diseases. The interdisciplinary research and training programme will cover a broad spectrum of approaches and topics, from intracellular molecular interactions to cell–cell communication, gene expression profiling, the impact of deleterious mutations, behavioral studies, and translation regulation. Coupled with extensive network-wide transferable skills training, this will prepare the fellows for careers in the medically important field of neurobiology as well as a broad range of carriers including government and industry.

Mots clés : c elegans, neurons, differentiation, degeneration, ethical model

Participants :
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 282693.6 €
- Debatrix v.o.f. (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université d'Utrecht (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 823111.2 €
- Magnitude biosciences limited (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université libre de Bruxelles (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 393930.0 €
- Université de Durham (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Rnassist ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Lyon-I université (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 424040.4 €
- Université de Strasbourg (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Loopbio gmbh (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institute of Science and Technology Austria (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 270331.2 €
- Sarah blackford (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Centre européen de recherche en biologie et en médecine (France) — Partner, beneficiary, Recherche, subvention : 282693.6 €
- Agentek (1987) ltd (Israël) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut Weizmann (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 271432.8 €
- Resonance voice training ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Bordeaux (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €