Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SOLVE-H (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The rising housing cost overburden rate, increasing house prices and rising rents in the EU, and lack of access to affordable/ adequate/ quality housing has increasingly become a major concern for low- and middle-income groups and vulnerable communities. As a response to this on-going crisis, the last two decades have witnessed a shift and re-emergence towards several forms of decentralisation, co-creation, and participative planning in housing in Europe, often referred together as forms of collaborative housing (CoH). Despite these prevalent forms that are typically driven with the need of affordability and social inclusion, the challenges around housing continue to increase (eg. Migration, gentrification, ageing population) leading to greater socio-demographic issues (social exclusion of vulnerable groups, socio-economic segregation, displacement in rental housing markets etc.), and making it a chronic crisis.  But, lack of verifiable systematic and quantitative evidence is a major barrier and does little to support the potential of these CoH forms in mitigating the issues. The knowledge around participation in CoH or its impact remains qualitative and fragmented, compromising a comprehensive understanding of the actual social value brought by them in terms of how they are capable to address the changing dynamics of housing in Europe with ongoing and emerging issues.  Thereby, SOLVE-H proposes a clear structure to develop an evidence-based index, enabling to map of social value of participation and capture the social impact of ‘collaborative’ trends in housing. The project addresses the social complexity project through mixed-method approaches from interdisciplinary disciplines (eg. sociology, citizen science).  The main objectives are to: • understand the social value of participation in CoH • enable evidence-based quantification of social value of participation in CoH • localise the developed social value index and facilitate its application for CoH in Europe

Mots clés : collaborative housing, cooperative housing, affordable housing, social housing, citizen participation, social value

Participants :
- Institut universitaire de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 356093.04 €
- École polytechnique fédérale de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Comite europeen de coordination de l'habitat social aisbl (Belgique) — Partner, associated partner, Autres, subvention : 0.0 €
- Urbamonde (Suisse) — Partner, associated partner, Autres, subvention : 0.0 €
Projet ManCoProc (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Pharmaceutical industry is starting to adopt the approach of continuous manufacturing, with as few unit operations as possible, to deliver drug products in a faster, robust, cheaper and sustainable way. Poor mechanical properties of many drug substances are a hindrance to this, making them unsuitable for direct compression into tablets without additional operations. This challenge can be solved by co-processing: joining the particles of such drugs to the particles of inactive substances known as excipients (e.g. lactose), normally used for tablets production. The aim of this project is to develop a universal drug-excipient co-processing (CP) platform based on surface crystallization or co-precipitation. A CP method in a milifluidic device will be optimised with a range of drugs with differing physicochemical properties. The relationships between them, as well as excipient properties, parameters of the method and structural and functional characteristics of the obtained composites will be thoroughly investigated. To this end, cutting edge techniques will be employed to analyse particle size, morphology, dissolution and mechanical behaviour. To demonstrate improved manufacturability, the prototype CP material will be used for direct compression, and the tablets quality will be evaluated according to European Pharmacopeia requirements. The project will enable the researcher to achieve professional maturity in the field of particle engineering, allowing to employ her skills both in academia and in pharmaceutical industry. The results of the research will have commercialisation value, being of interest to companies as a potential new platform in (pre)formulation portfolio. The project will contribute to the body of evidence informing the decisions of regulators on pharmaceutical co-processing. In the long term, such impact should advance the transformation towards continuous manufacturing of affordable, available and sustainable drug products.

Mots clés : pharmaceutical technology particle engineering crystallisation

Participants :
- Zentiva ks (Rép. Tchèque) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut de technologie chimique de Prague (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 119097.32 €
Projet SQPRIM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Quantum computers pose a huge threat to cybersecurity, with the potential of solving complex problems in just a fraction of the time it takes to the most powerful supercomputers today. With conventional public key infrastructure (PKI) cryptography at risk, we face the task of securing our digital systems with the development of new cryptographic primitives for the post-quantum era. Inspired by nature, this project aims to developing the biometric equivalents of fingerprints and DNA for the digital world that will univocally and individually identify hardware. For this goal, Physically Unclonable Functions (PUFs) will be developed to provide hardware-based digital identifiers that will be utilised to build lightweight encryption and robust authentication procedures. But creating such unique structures is challenging in a fast-growing digital environment with increasing demand for new interconnected devices, such as the Internet of Things (IoT). To achieve this goal, we will combine light and sound. We will use ultrasound (US) waves to control the travel path of a light beam transmitted through a scattering medium to generate unique patterns. This novel method can potentially generate a high number of unique patterns while reducing the cost and complexity compared to current systems exploiting optical PUFs. The proposed device is expected to be unconditionally unclonable and, therefore, safe in the post-quantum era. This project will also explore the integration of the proposed novel PUFs with CMOS-based cryptographic primitives to create IDentity of Things (IDoT). The proposed solution is expected to be of relevance in a wide spectrum of application domains such as financial systems, medical services, energy industry, governments, and citizens.

Mots clés : puf, cybersecurity, photoacoustic effect, ultrasound, optical scattering, speckle pattern, iot, cryptographic primitive, optical sensor, photonics, quantum security

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet GlycoGuard (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Pathogens exploit glycosphingolipids (GSLs) on the surface of gut epithelial cells to initiate infection. A recent breakthrough has uncovered a novel, cell-autonomous immune response in which multivalent clustering of GSLs by bacterial toxins or viruses triggers the degradation of the cell polarity protein PARD6B, leading to reduced pathogen uptake. This novel GSL-PARD6B pathway highlights the critical role of GSLs in mucosal immunity. However, the precise molecular mechanisms by which GSL binding initiates this intracellular signaling cascade and the subsequent changes to the host membrane composition are not fully understood. By integrating novel biochemical techniques with my existing skills in GSL-pathogen research, I will: 1) Define the triggering mechanism of the GSL-PARD6B pathway and, 2) Determine the effects of the microbiota and the GSL-PARD6B pathway on plasma membrane composition. This work will reveal how extracellular signals are translated across the plasma membrane to modulate intracellular responses and uncover mechanisms that protect against infection. Overall, the GlycoGuard project intends to provide a comprehensive understanding of the GSL-PARD6B pathway, advancing our knowledge of host-pathogen interactions and paving the way for novel therapeutic strategies against infections. Additionally, this grant will enhance my skills as a researcher and provide the foundation to establish myself as an independent scientist.

Mots clés : glycosphingolipids, host pathogen interactions, mucosal immunity, cellular signaling pathways, nanodomains, microbiota, bacterial toxins

Participants :
- Boston Children's Hospital (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université Johns-Hopkins (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 442099.44 €
Projet ROICAM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Metabolic dysregulation is a hallmark of numerous diseases. Multiphoton microscopy (MPM) combined with fluorescence lifetime imaging (FLIM) of the metabolic coenzymes NADH and FAD has emerged as a key method for monitoring metabolic processes in live tissue with sub-cellular resolution. However, recent data demonstrates that spectral crosstalk from other cellular components, such as keratin, is substantial. Yet the contributions from endogenous proteins are often neglected, bringing into question the validity of earlier studies. To address this issue, we propose to systematically scrutinize the fluorescence properties of NADH, FAD and keratin in different states and combinations. This will be done by meticulous investigation of the fluorescence lifetime, spectra and related photophysical properties using MPM and time-resolved spectrophotometry under a range of conditions (pH, temperature, viscosity, protein binding), and in combination with computational chemistry. Based on this knowledge, we will develop approaches that can accurately determine the concentration, diffusion and binding state of NADH and FAD even in the presence of spectral crosstalk from keratin. The strategy is to implement phasor-FLIM analysis, fluorescence lifetime correlation spectroscopy (FLCS) and raster lifetime image correlation spectroscopy (RLICS) to separate the fluorescence contributions of bound and unbound NADH and FAD from the protein background and quantify the spatial distribution of each species with unprecedented spatiotemporal resolution. The developed methodologies will be validated by monitoring cellular metabolism in human primary cells and tumour cell lines. This study will solidify our understanding of NADH and FAD autofluorescence in complex cellular environments and substantially expand the analytical toolset by which quantitative information about metabolic dysregulation can be obtained, thereby advancing MPM-FLIM as a research and diagnostic tool for metabolic diseases.

Mots clés : flim, multiphoton microscopy, cellular autofluorescence, metabolic imaging

Participants :
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
Projet FiP (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This research project advances theoretical and applied knowledge about communication practices in professional training in high-stake, high-risk professions, focusing on the rescue services. The overarching objective of FEEDBACK IN PRACTICE (FiP) is to specify how the design of instructors’ feedback is consequential for the trainees’ understanding and acceptance of indicated problems and eventual implementation of the feedback content in subsequent training. More specifically, the project sets out to: a) identify and account for actual instances where instructors and trainees manifestly engage in and accomplish feedback processes on practical training; b) determine the relevance of the sensorial dimension of the exercises in relation to their assessable aspects; and c) outline a roadmap for navigating actual instances of feedback in interaction. The data will include approximately 80 hours of already initiated videographic documentation of naturally occurring firefighters’ training and subsequent debriefing sessions in Switzerland and Sweden. The recordings will be transcribed and analyzed using a multimodal, social interactional, comparative and interdisciplinary approach to identify and explain critical instances of feedback during practical training. The project is conceptualized as part of an innovative collaboration with three international and interdisciplinary research projects on feedback in other domains of professional training. The research will break new grounds regarding how feedback, as a generative practice for carrying out pedagogical tasks, is normatively ordered and relies on vernacular linguistic, embodied and sensorial resources. By developing a communication model in cooperation with associated experts, the project will contribute to the advancement of the existing curriculum in high-risk practical training, which will be instrumental for securing and improving skills in exigent and essential professions such at the rescue services.

Mots clés : multimodal interaction analysis, professional training, linguistics, embodiment, firefighting

Participants :
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
Projet LG-Conflict (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Decentralization reforms in the Global South have witnessed a surge since the 1980s, embraced by governments and international donors as a solution to myriad problems from poor public services and territorial inequalities to corruption and low public trust. Decentralization reforms have been introduced across the Middle East and North Africa (MENA). Many of these reforms are strongly supported by international donors on the assumption that they promote citizen participation, accountability and local development. However, there is little empirical assessment of whether decentralization reforms are, in fact, achieving these purported benefits. Following decentralization reforms in the MENA in the past decade, prominent conflicts have taken place between appointed and elected subnational officials. The researcher's own PhD research on the politics of decentralization reforms in Tunisia in 2011-19 suggests that decentralization reforms and the entry of thousands of elected local councillors into politics is challenging the existing distribution of power between elected local politicians and centrally-appointed regional or municipal officials. Conflicts between these two groups and their outcomes have significant implications for both the democratic and developmental benefits of decentralization. This research project seeks to identify to what extent decentralization reforms serve to redistribute decision-making power from central government to local elected representatives, and under what conditions. Specifically, it asks when and why appointed central government representatives and local elected officials come into conflict following decentralization, and under which conditions local elected officials are able to successfully resist bureaucratic opposition where conflict occurs, thus asserting local autonomy. These questions are central to reform processes that can deliver tangible improvements for the lives of millions.

Mots clés : decentralization, local governance, bureaucracy, political transitions, public administration

Participants :
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
Projet SOCIAL (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Contemporary political philosophy must address the rise of autonomous social sectors (economy, media, science) that escape state regulation by expanding beyond national borders and that challenge traditional forms of politics. The problem at stake is the relationship between civil society and state which Hegel first outlined from the perspective of the nation-state and which has since been radically reconfigured. SOCIAL aims to develop a new approach to this issue by investigating today’s autonomisation of economic, social and cultural institutions and their integration at the political level. The purpose is to contribute to the debate on the specificity of a transnational subject by introducing conceptual tools in the wake of Hegelian institutional theory. The research will focus on the Hegelian philosopher A. Kojève who explored the possibility of a civil society beyond the state and the relationship between the social and the political on a post-national scale. SOCIAL will highlight the common ground between this neo-Hegelian model and contemporary reflections on societal constitutionalism – in particular the work of the jurist G. Teubner – to outline a new transnational societal constitutionalism in a global perspective. The research will draw on the evolution of functional systems and on institutional pluralism, aspects that current majoritarian approaches such as Kantian cosmopolitanism or Rawlsian theory of international justice do not sufficiently take into account. SOCIAL aims to provide a unified perspective and a new way of conceiving philosophical research in current dialogue with extra-philosophical fields and contemporary debates. Its originality lies in the integration of a neo-Hegelian perspective in political philosophy with different traditions like the theory of social systems and legal pluralism, which are crucial for understanding the structure of society in a world articulated by the coexistence of many parallel legal orders beyond the state.

Mots clés : social and political philosophy, philosophy of right, hegelianism, koj ve, social constitutionalism, legal pluralism

Participants :
- Université de Namur (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet DENOVO (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

As memorizing new information relies on distinguishing the new from the familiar, novelty detection is closely tied to memory. Yet, the exact nature of this link remains unclear—are they two sides of the same function or rather distinct yet interacting processes? Critically, there are different types of novelty: absolute (new stimulus) or contextual (familiar stimulus in unexpected context). The ultimate goal of the MSCA "DENOVO" project is to develop an integrative model of the relationships between episodic memory and these novelty types. Specifically, I will test the way novelty types interact with memory: unitary relation for absolute vs. independence for contextual. I will design innovative tasks and use complementary approaches of neuroimaging, neuropsychology, and cognitive psychology in 3 work packages—(i) a correlational study in volunteers aged >55 to examine the relationship between novelty and memory, (ii) a neuropsychological study with memory-impaired patients (probable Alzheimer’s disease (AD) and amnestic Mild Cognitive Impairment) to probe the impact of underlying brains network dysfunction and to characterize the patterns of impairments across novelty types at AD stages, and (iii) analysis of longitudinal data from a cohort of subjects aged >60 to study the temporality of changes in novelty types in relation to memory decline and brain regions atrophy. Beyond ground-breaking advances in understanding memory function, the insights will be of great interest to clinicians for both diagnosis and rehabilitation of memory disorders. Altered precociously in AD, absolute novelty may be an early diagnosis marker while contextual novelty, which boosts memory encoding, may be a compensation strategy. Personally, thanks to the expertise of my host and secondment labs, DENOVO will equip me with essential technical and clinical skills, advancing my long-term career goal of conducting research using neuropsychological approaches to study episodic memory function.

Mots clés : episodic memory memory alzheimer s disease aging novelty detection mild cognitive impairment

Participants :
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Liège (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet BRACTION (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Since their discovery in 1979, brassinosteroids (BRs) have been extensively studied for their biosynthesis and signalling pathways. Now, in the year 2023, one fundamental question remains: how do BRs move? As the only type of steroidal phytohormones essential for plant growth and development, BRs act in a dose-dependent manner and do not travel long distances. Therefore, BR homeostasis is key to their function. Recent findings in my host lab revealed that in the Arabidopsis root the expression domains of BR biosynthetic enzymes are separated, and the completion of BR biosynthesis requires cell-to-cell movement of precursors, thus, revealing the importance of the short-distance transport for BR homeostasis maintenance. Further we revealed that plasmodesmata (PD) mediate the passage of BRs between neighbouring cells. However, we still do not know where in the cell BRs are synthesized and how these hydrophobic molecules are moving through PD. By searching interactors of BR biosynthetic enzymes, my host lab found interesting candidates associated with the endoplasmic reticulum (ER)-plasma membrane (PM) contact sites (EPCSs), including PD. EPCSs are known lipid synthesis platforms and contribute to PD function in plants. Here, I hypothesize that BRs are synthesized at EPCSs, and EPCSs coordinate BR biosynthesis and transport through PD. In BRACTION, I will combine live cell imaging with state-of-the-art imaging techniques to pinpoint BR biosynthesis sites in the cell. Combining advanced proteomics, genetics, and biochemistry, I aim to identify novel candidates that regulate BR biosynthesis and movement linked to EPCSs. Finally, I will employ genetics combined with bioorthogonal chemistry approach to assess candidate influence on BR symplastic movement. BRACTION's interdisciplinary approach will address knowledge gaps in BR homeostasis and drive major conceptual advances in understanding how BR levels are maintained across different cell types and tissues.

Mots clés : brassinosteroid biosynthesis symplastic transport endoplasmic reticulum plasma membrane contact sites advanced imaging protein protein interactions

Participants :
- Vlaams Instituut voor Biotechnologie (Belgique) — Coordinator, beneficiary, Recherche, subvention : 175920.0 €