Projet DRUGtrain (Horizon 2020, appel à projets 2020)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Drug repurposing (or repositioning) is the application of previously identified drugs or compounds to treat new indications. The International Rare Diseases Research Consortium (IRDiRC) set as main goal for 2027 that 1000 new therapies for rare diseases will be approved. One of the levers to achieve this goal includes the repurposing of already existing and marketed drugs. In this context, DRUGtrain offers a timely paradigm for multidisciplinary research ideal for improving drug repurposing and development strategies of compounds, with Autosomal Dominant Polycystic Kidney Disease (ADPKD) as example. Identifying compounds for repurposing requires a broad variety of approaches. Therefore, the aim of DRUGtrain is to offer a multidisciplinary research training program to young researchers preparing them to become leading scientists able to integrate molecular and pharmacological data, and translate fundamental research questions to the (pre)clinic and vice versa. The research objectives of DRUGtrain are: 1) To identify potential drug targets and drug candidates for repurposing using innovative bio-informatics and cheminformatics approaches; 2) To perform drug testing/drug screenings in advanced in vitro and in vivo models, ultimately leading to testing of new treatment strategies; 3) To clarify drug mechanisms, and identify and reduce adverse events using state-of-the-art technologies from in silico and wet lab methodologies. Complementary training through courses will cover additional topics in drug repurposing and drug discovery as well as scientific skills, personal development, commerce and entrepreneurship. In DRUGtrain, 6 academic and 4 private sector beneficiaries/partner organisations and 1 NGO are collaborating in joining forces to intensify network activities between academia, industry, and a patient organization. The training offered should support the ESRs in becoming the next generation of true multidisciplinary researchers in (bio)pharmaceutical sciences.

Mots clés : drug repurposing, drug treatment strategies, bioinformatics, cheminformatics, data mining, autosomal dominant polycystic kidney disease

Participants :
- Universitätsklinikum Aachen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- Janssen (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 256320.0 €
- University of Konstanz (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- Crown bioscience netherlands bv (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 265619.88 €
- University of Manchester (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
- University of Santiago de Compostela (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 250904.88 €
- Uppsala University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281982.96 €
- Leiden University Medical Center (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 531239.76 €