Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet NES3ACOM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

In the current climate emergency and energy crisis, the need to reduce energy and raw material consumption is undoubtedly imperative in the context of a more environmentally and resource-conscious society. Bearing in mind that steel is the most produced metallic material in the world, 1900 million tonnes per year, it is not surprising that a large number of scientific and technological resources are devoted to simplifying its compositions, improving its properties, and optimizing the necessary processing. In line with this, in this proposal, New Sustainable Steel For Automotive Components NES3ACOM, we have found a niche of study and development in which we intend to develop a new steel, belonging to the Medium Manganese Steels (MMS) family, which can be used to manufacture two security components for the automotive industry, one for anti-intrusion and the other for energy absorption, by means of two types of specific processing, more energy efficient than those currently used. While in the case of Anti-Intrusion, a homogeneity in the chemical composition of the different microstructural phases is pursued, in the case of Energy Absorbing the heterogeneity of these compositions will be exploited, which is a product of the steel manufacturing process and therefore innate to it. In the framework of the NES3ACOM project, during the design process of this alloy, a plethora of processing parameters, solid-state phase transformation theories of steels, microstructure-processing relationships, properties-microstructure, etc. will have to be combined and taken into account in order to obtain, after processing the steel, the optimum microstructures whose properties equal or improve those required for the two applications at a lower environmental cost than at present.

Mots clés : medium manganese steels, phase transformation, heat treatment, martensite, intercritical annealing

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet KAPP (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In the two centuries leading up to the Expulsion from the Iberian Peninsula, Jewish communities continuously grappled with internal discord and shifting relationships with Christian rulers and Muslim neighbours. Internally, two significant intellectual divisions took shape: one targeted the nature of knowledge, setting philosophers against kabbalists; the other revolved around the interpretation of Jewish law, split between advocates of symbolic exegesis and proponents of literalism. Additionally, a parallel rift rooted in demographic factors between Jews steeped in Islamic traditions—emphasizing philosophical speculation and esoteric imagery—and those from central European regions—primarily invested in Talmudic studies and pietistic spirituality—increasingly overlapped those intellectual divides. Externally, these same communities were wrestling with the rise of Christian dominance and the waning of Islamic culture. All these tensions are embodied by the Banū Waqār family. Andalusian in origin, they lived in various cities, served the crown, and authored works in different languages on varied subjects. They reached their literary peak with Joseph b. Abraham’s massive yet little-explored “Conciliatory Treatise between Philosophy and Tradition”. This Judæo-Arabic work aimed both to address the pressing intellectual challenges and to mend the communal fabric. KaPP will unfold in two phases: first, a historical exploration of the Banū Waqār family, examining their contributions to the landscapes they inhabited; second, an analysis of the philosophical depth and political ramifications of Joseph’s magnum opus. Through this bifocal lens, KaPP seeks to redefine our understanding of the interplay between these conflicts, illuminating the critical roles that philosophers, kabbalists, and scholars with divergent interpretations of Jewish law played as social forces, thereby rendering age-old debates about the intricate mosaic of medieval Jewish life in new, sharper contours.

Mots clés : medieval iberia medieval intellectual history jewish islamic crosspolinations medieval jewish history medieval jewish philosophy jewish studies joseph b abraham ibn waq r

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet TUMBET (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The circulation of upper and intermediate (AW and WIW) water masses play a key role in the hydrodynamics of the Western Mediterranean, where these water masses flow cyclonically along the slope, exhibiting seasonal fluctuations in volume transport. Upon reaching the Balearic sub-basin, the flow splits, with one branch moving south towards the Balearic Channels, while the other forms the north Balearic Current (BC) along the northern slope of the Balearic Islands. Although the Balearic Channels have been recognized as a major pathway for AW and WIW, significant gaps remain in understanding their circulation and volume transports, particularly along the northern Balearic slope and the broader circulation around the Balearic Islands. This project aims to quantitatively characterize the properties and transport of upper and intermediate water masses in the Balearic region, using high-resolution underwater glider data from five areas around the archipelago. The expected results are: 1) a better understanding of the role of the BC in AW and WIW circulation, 2) a detailed characterization of the oceanographic properties of these water masses in seasonal and interannual contexts, and 3) quantify their transport rates in the BC compared to the Balearic Channels and other regions of the archipelago. The host institution expertise in physical oceanography, marine biogeochemistry, and climate change in the Mediterranean Sea will be crucial for the project’s success and the applicant’s training. The planned secondment will focus on using inverse box models to assess water mass transports, leading to a more in-depth knowledge of circulation patterns in the Balearic Islands. This pioneering work will extend European leadership in Mediterranean hydrodynamic studies, address key EU challenges under Horizon Europe and provide valuable insights for numerical modelers. TUMBET represents an extraordinary opportunity for the applicant’s scientific and professional development.

Mots clés : oceanography, water mass circulation, hydrography, hydrodynamics, biogeochemical variability, inverse box models, underwater gliders, climate change, mediterranean sea

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 226420.56 €
- Conseil national de la recherche (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet WHAM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

Mots clés : physical activity, exercise, wheelchair users, disability, behaviour change, wearables

Participants :
- Maastricht instruments (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de la Colombie-Britannique (Canada) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université norvégienne de sciences et de technologie (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 328251.12 €
Projet REGENER-OMIX (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Upon injury or disease, most human organs yield fibrotic tissue resulting in permanent scars and the failure of tissue function, compromising the health span and lifespan of affected individuals. Organ fibrosis is influenced by a myriad of factors, including fibroblast heterogeneity, the activated signal transduction pathways and environmental cues. Fibroblasts hold a central role in fibrosis, yet a nuanced understanding of their heterogeneity driving regenerative versus fibrotic healing remains elusive. Recently, it was shown that the microbiome regulates inflammation and extracellular matrix remodeling. However, the microbiota function in tissue regeneration and fibrosis is poorly characterized. Integrating microbiome insights into anti-fibrotic approaches is an uncharted territory. REGENER-OMIX aims at investigating: 1. fibroblast heterogeneity and, specifically, the microbial components-recognizing fibroblasts, and the wound microbiome in the regenerative oral mucosa and pro-fibrotic skin; 2. the fibroblasts-microbiome crosstalk through spatial analysis; 3. the role of the microbiome in the healing outcome toward regeneration or fibrosis.  To address these objectives, I will leverage advanced transgenic models, cutting-edge single nucleus RNA-seq, multi-omics and spatial biology techniques through a novel and interdisciplinary approach. The project (36 months) will unravel the interactions between fibroblasts and microbiome, and their functional role in regeneration and fibrosis. This study will offer new avenues to manipulate the healing process and antagonize fibrosis-associated pathologies.  I will combine the strengths of a USA-based research group, world-leading expert in wound healing and fibrosis, with the expertise of a world-renowned Europe-based laboratory, who pioneered host-microbiome research. This sets the stage for a unique environment for my postdoctoral training, knowledge exchange and new research lines to be explored.

Mots clés : fibrosis, regeneration, multi omics, fibroblasts, skin, microbiome, oral mucosa, spatial biology, tissue repair

Participants :
- Université Stanford (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Helmholtz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 401232.0 €
Projet MechPep (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Mechanically interlocked molecules (MIMs) feature mechanical bonds, which link multiple distinct components together allowing free movement between them without dissociation. This makes MIMs perfect candidates for artificial molecular machines, and earned them the Nobel Prize in Chemistry 2016. Over the last 30 years, MIMs have been applied in diverse areas from switchable catalysis to smart materials. However, they have so far only found limited use in biomedicine, due to the often lengthy synthesis and poor solubility in biological media. Directly addressing these challenges, we will use Nature’s own building blocks (i.e. peptides) to construct stimuli-responsive MIMs for use in bioapplications. Rotaxanes are a class of MIM resembling dumbbells, with a macrocyclic ring encircling the axle. We will use bioactive peptides as the rotaxane axle (making them intrinsically biocompatible MIMs) whose bioactivity will be initially silenced via obstruction of the encircled stimuli-responsive macrocycle, which acts as “protective armour” and stabilises the peptide. Upon application of a stimulus (e.g. light irradiation), self-immolative cleavage of the macrocycle occurs, liberating the free peptide. Hence, light acts as a stimulus to turn-on the bioactive response of the peptide on-demand. We will use this to design advanced biosensing systems for stimuli-responsive MMP2 cleavage of the peptide sequence PLGLAG. Further, we will develop beyond state-of-the-art photopatterning methods for cell adhesion, using the integrin-binding RGDS peptide sequence as our rotaxane axle. Using the high spatiotemporal control of light, we can turn on cell-adhesion where desired via self-immolation of the macrocycle using light irradiation. This action represents a precise, high-resolution method for the photopatterning of cell-adhesive biomaterials, a crucial first step for the use of peptide-coated biomaterials in therapeutics e.g. transplants, skin-grafts, and drug delivery platforms.

Mots clés : mechanical bonds, rotaxanes, mechanically interlocked molecules, stimuli responsive molecules, rgds, photopatterning, comformational analysis

Participants :
- KTH Institut royal de technologie (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet PROGRAM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : CLOSED

Many strongly-correlated phenomena in condensed-matter and high-energy physics, from high-Tc superconductivity to quark confinement, can be described by lattice gauge theories (LGT), field theories invariant under local transformations. The immense computational complexity associated with solving LGT using classical computers hinders progress in these fields, where many questions remain open. Although quantum computers can address these questions more efficiently than classical devices, current quantum hardware is limited in the absence of error correction, complicating the reach of a practical quantum advantage in the near term.  Co-designing both quantum hardware and software tailored to simulate LGT, addressing non-trivial regimes while minimizing experimental resources, is therefore a challenging but timely task. Rydberg atoms in tweezer arrays, which have recently emerged as a powerful quantum simulation platform, offer unique capabilities that can be harnessed in this direction. On the one hand, the strong Rydberg interaction and the associated blockade mechanism naturally leads to emergent local symmetries. On the other hand, the possibility of controlling many internal atomic states as well as using fermionic atoms allows to locally encode and simulate non-abelian gauge fields and fermionic matter fields, respectively, minimizing resource overheads.  PROGRAM will investigate this hardware-efficient approach and develop quantum simulation protocols for LGT using Rydberg atom arrays, focusing on three main challenges: (i) simulating non-equilibrium LGT dynamics in 2D, and (ii) implementing non-abelian gauge symmetries, as well as (iii) fermionic matter fields, in a scalable manner. The Researcher will design these protocols using both analog, digital and variational near-term resources, benchmark them in the presence of experimental errors, and run some of them using existing quantum hardware.

Mots clés : quantum simulation lattice gauge theories quantum computing rydberg atoms

Participants :
- Université Harvard (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 216699.6 €
Projet Asense (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Lab-on-chip (LOC) devices are useful for manipulating, analyzing, and interacting with small samples in a wide range of applications. Wireless LOC devices have been developed for remote and distributed analysis purposes where wired measurements are not feasible or cost-effective. The devices consist of a miniaturized array of biochemical sensors connected to a low-power radio transceiver. The current trend in wireless LOC devices is to miniaturize the sizes, lower the power consumption, and increase the processor capacity while driving down costs which are rapidly approaching their practical and theoretical limits. These raise the need for a new design to support the future sustainability of these devices to facilitate the current and upcoming massive deployments for use in various applications. Triggered by this, the project explores the revolutionary secondary use of the wireless antenna for multi-analyte active sensing purposes by deploying case-tailored sensing nanomaterials on the antenna surfaces current spots with each targeting a specific analyte using a Molecular Imprinting Polymer (MIP) layer grown above a highly conductive 2D transduction nanomaterial layer. The idea is to move the complexity from the wireless LOC to the computation of the gateway station, where signal processing and machine learning techniques are employed to remotely sense the targeted analytes. This is done by detecting changes on the radiation characteristics of the antenna caused by the applied sensing materials. The idea of using the antenna as a multi-analyte active sensor is an absolute novelty. If successful, the approach will have a huge contribution in reducing the hardware complexity of standard wireless LOC devices by at least 50% (no need to sensor integrated circuits, microcontrollers, and their associated power consumption), resulting in more than doubling their battery lifetime due to less power consumption, making large-scale mass deployment economically feasible.

Mots clés : antenna design, sensor antennas, wireless biochemical sensors, lab on chip devices, nanomaterials, sensitive materials, wireless communications, signal processing, machine learning

Participants :
- Université norvégienne de sciences et de technologie (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226751.04 €
Projet MIGRALIGHT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The itinerant lifestyle of migratory species makes them especially vulnerable to changes in environmental conditions. Understanding how migratory species respond to human-induced changes in the environment is nowadays of paramount importance to conserve migratory species and the diversity of migratory behaviours. In particular, urbanisation and artificial light at night (ALAN) could have important impacts on migratory species. Urbanisation changes environmental harshness, potentially offering new wintering areas with milder temperatures and higher food availability for migratory species. ALAN modifies the airspace over which individuals migrate, potentially fragmenting the sky and generating barriers for airborne migratory animals. Understanding how these two anthropogenic factors affect migration and its population consequences are now essential to anticipate the response of migratory species to anthropogenic global change. Combining expertise from the Swiss Ornithological Institute (Switzerland) and Doñana Biological Station (Spain), this interdisciplinary project will investigate how urbanisation and ALAN affect long-distance bird migration and the evolutionary implications of such effects. Specifically, this project will (i) identify differences in migratory behaviour between urban and non-urban bird populations; (ii) test the effects of ALAN on migratory behaviour across a broad geographical range; and, (iii) determine the genetic population structure and connectivity of migratory populations exposed to varying levels of anthropogenic environmental pressure. To address these questions, this project will use a long-distance migratory owl, the Scops owl (Otus scops), an ideal species to achieve the aims of this project. The findings of this project have the potential to inform conservation plans for migratory species and the management of ALAN in cities.

Mots clés : bird migration, urban ecology, urbanisation, alan, artificial light at night, ornithology

Participants :
- Schweizerische vogelwarte sempach (Suisse) — Partner, associated partner, Recherche, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 317205.6 €