Projet MiCCrobioTAckle (Horizon Europe, appel à projets 2023)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Microbiota medicine is the new frontier in human health. The human gastrointestinal tract is home to trillions of microbes. Under normal conditions, these microbial communities drive physiological and homeostatic functions in the host; when altered, they can lead to severe disorders. With an increasingly recognized role in health and disease, the gut microbiota offers promising therapeutic and diagnostic potential to tackle various pathologies (incl. metabolic, neurological, and cardiovascular disorders). Its full clinical potential remains largely unrealized though, mostly due to the lack of critical mass capable of integrating the multiple scientific and translational dimensions of microbiota medicine. Grounded on a team of 180leading researchers and entrepreneurs from across 12 countries and dispersed disciplines (biological big data analytics, systems and synthetic biology, experimental and translational medicine), MiCCrobioTAckle will train 12 Doctoral Candidates (DCs) with the much-needed cross-disciplinary and -sectoral expertise to advance microbiota medicine. As course-setting disease, the DCs will focus on cancer cachexia (CC). CC is an excellent model to study the host-microbiota axis in the context of metabolic diseases and represents the paradigm of a devastating condition in urgent need of new and more efficient means of clinical management. Along MiCCrobioTAckle, the 12 high-calibre DCs will foster new discoveries with impact on CC, while driving scientific and technological progress in microbiota medicine in its broadest scope. By training the next generation of researchers with out-of-the-box thinking and an entrepreneurial mindset in microbiota medicine, MiCCrobioTAckle will safeguard the EU leadership in this vanguard and imperative biotech/pharma segment, while paving the way for the development of novel gut microbiota insights and tools to tackle multiple diseases with foreseeable impact on the well-being of billions of citizens worldwide.

Mots clés : cancer cachexia gut microbiome metabolomics synthetic biology in vitro models murine models fmt

Participants :
- Helmholtz-Gemeinschaft (Allemagne) — Partner, beneficiary, Recherche, subvention : 260539.2 €
- Université Rovira i Virgili (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Presymptom health ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Semmelweis (Hongrie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université catholique de Louvain (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Heidelberg (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Ms-omics aps (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Snipr biome (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Seqbiome ltd. (Irlande) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Biofaction (Austria) (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University College Cork (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 572976.0 €
- Oslo Cancer Cluster (Norvège) — Partner, associated partner, Autres, subvention : 0.0 €
- Dnasense aps (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Chr. Hansen (Denmark) (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Friedrich-Schiller d'Iéna (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre de recherche de Biologie de Szeged (Hongrie) — Partner, beneficiary, Recherche, subvention : 228348.0 €
- Université technique du Danemark (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 603576.0 €
- University College Dublin (Irlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Community initiatives (Etats-Unis) — Partner, associated partner, Autres, subvention : 0.0 €
- Abzu aps (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Single-cell technologies kft (Hongrie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Leibniz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 749412.06 €
- Biomarker technologies (bmk) gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Reformatus pulmonologiai centrum (Hongrie) — Partner, associated partner, Autres, subvention : 0.0 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 823111.2 €