Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet NIR-NanoCAR (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a 5-year survival rate under 10%. Current treatments for PDAC are based on ineffective and unspecific drugs that cause hard side effects. Besides, new T cell-based immunotherapies are toxic and unsuccessful in most solid tumors, including PDAC. Activating KRAS mutations occur in almost all patients, but unfortunately, KRAS is difficult to target. This discouraging situation highlights the need to design orthogonal and innovative strategies that target different pro-tumoral axes, in order to increase the antitumor effect minimizing side effects. In NIR-NanoCAR project, we will develop a new concept of therapy, Near-Infrared (NIR) Photothermal Nano-CAR Immunotherapy (NIR-PNCI). To test this concept, we will fuse i) thermosensitive liposomes capable to mediate photothermal therapy by NIR, with ii) exosomes derived from mesothelin-CAR T cells armored with IL-12 (which maintain effector molecules from their parental cells) and loaded with siRNA targeted to mutated KRAS. We will explore the antitumor capability and the tumor microenvironment-reprograming mediated by the hybrid nanotherapy in a relevant murine PDAC model. If successful, this nanosystem will be a breakthrough with a paradigm shift in the strategy to design the next generation of nanoimmunotherapies for solid tumors.

Mots clés : exosomes, liposomes, immunotherapy, nanomedicine, car t cells, mutated kras, pancreatic cancer

Participants :
- International Iberian Nanotechnology Laboratory (Portugal) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Grenade (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet SolvEMCA2 (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The electromagnetic compatibility (EMC) certification methods of aircrafts are predominantly based on experimental testing to fulfill some standard (e.g. DO-160). This phase involves costly measurement techniques, and high rework costs are required when EMC weaknesses and vulnerabilities are detected, especially at late development stages. To alleviate this situation, numerical solvers are increasingly considered to complement and support experimental means. Numerical solvers enable the engineer to address the full complexity of a problem, and to better understand the impact of changing key parameters in shielding. In this work, we will address two challenges currently identified by aeronautic industry. First, we will develop suitable macroscopic models of novel nano- and micro- engineered smart materials used jointly with Carbon Fiber Composite (CFC) ones, to be used in full-wave numerical solvers in general, and specifically in the Finite-Difference Time-Domain (FDTD) method. For this, we will start from their microscopic structure to get realistic macroscopic electric and magnetic dispersive iso/anisotropic (and eventually non linear) constitutive parameters. Second, specific subcell models of junctions, slots, gaps, curvatures, etc. will be devised for their implementation into FDTD, to prevent brute-force simulation approaches of geometrically involved parts of the aircraft, otherwise computationally prohibitive. As a result, the FDTD method will be endowed with the capability of simulating realistic EMI problems of a whole aircraft with affordable computational resources, in terms of memory and CPU time, including CFCs and novel smart materials, with all geometrical fine details relevant from the electromagnetic point of view.

Mots clés : computational electromagnetics, electromagnetic compatibility, electromagnetic interference, finite difference time domain method, fdtd

Participants :
- Université de Grenade (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet ElectroNORM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Extraction of unconventional oil and natural gas by horizontal drilling and hydraulic fracturing (HF) is a real alternative to worldwide oil and gas production to guarantee the energy independence as well as the transition from non-renewable to sustainable energy. However, the large amount of wastewater generated, rich in natural toxic pollutants such as heavy metals, naturally occurring radionuclides (NORM), salts, etc.; concerns both stakeholder and public, especially from the radiological point of view. At present, the water treatment methods available are not capable to remediate the radioactive contamination of HF wastewater (WW). Nowadays, electro-adsorption is emerging as a powerful alternative to make more effective and sustainable the removal of pollutants, like heavy metals from WW. The main reason is that electro-adsorption has shown excellent advantages like minimal water waste, low operation cost, environmental friendly, high-energy efficiency, high removal efficiency, among others. However, little is known about removal of radionuclides by electro-adsorption, therefore, it is necessary to develop new electrodes increasing the adsorption surface, the pollutant selectivity, the stability, the regeneration as well as decreasing the resistance to ensure the removal of radionuclides. In this context, the aim of ElectroNORM project is to develop novel functionalized carbon aerogel as electrodes for the removal and isolation of highradiotoxic naturally occurring radionuclides from HF-wastewater by electro-adsorption.

Mots clés : naturally occurring radionuclides, electro adsorption, functionalized carbon aerogels, radiochemistry, unconventional gas and oil production, flowback, batch experiments

Participants :
- Université de Grenade (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet NetFoodIt (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The emergence of the Roman Empire marked a series of significant political and socio-economic changes across modern-day Italy as well as across a very large part of modern-day Europe. Among these, the establishment of a new transport network and the development of trade and commerce that this facilitated, was one of the most important and lasting changes. NetFoodIt aims at using imported food plants, for the study of Roman transport and movement and the socioeconomic dynamics that this established within the core of the Roman Empire and its broader surroundings, that is, across modern-day Italy. In doing so NetFoodIt will shed new light into the relation between mobility, commerce and the introduction of new tastes in Roman Italy. NetFoodIt will develop a geodatabase of Roman food imports assemblages and study their social access and rarity/regularity. In combination with the Roman transport network the project will next investigate the centrality of the sites with these imports, their character as consumption or redistribution centres and will reconstruct the routes for the distribution of these food plants. This will provide important insights into Roman commerce, economy and the extension and acquisition of new tastes as Rome expanded and developed contacts with other ancient cultures. In order to do so, a combination of novel techniques, which include Social Network Analysis, Site Rarity Index calculations, Spatial Network Analysis and spatial statistics will be employed in conjunction for the first time for Roman Italy. These methods and the training provided during their implementation by a team of leading international researchers will enhance the candidate's profile with cutting-edge techniques that will situate her at the forefront of research and boost her career.

Mots clés : archaeobotany, roman archaeology, spatial analysis, network analysis

Participants :
- Institut Català d'Arqueologia Clàssica (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet ACROSS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Previous research on palaeolandscapes has overlooked a main driver of landscape change: the mobility of human societies. When groups move they take with them their technology and ideas, but also plants, or land-uses which merge with native environments and practices to give birth to transported landscapes. This can lead to significant and long-lasting landscape changes -i.e. deforestation, introduction of exotic plants, erosion- that can be traced back through the use of combined palaeoenvironmental and archaeological techniques. However, the study of transported landscapes and their environmental impact has only rarely been addressed so far, and it is especially needed in Mediterranean coastal areas where migratory and colonial processes have had a particularly active role in the modelling of landscapes for millennia. ACROSS will fill this existing gap in current research by analysing two areas at the two sides of the Mediterranean Basin: Abdera (Thrace) and Emporion (Catalonia). They account for a long history of prehistoric peopling, and have ancient colonial relationships with the foundation of the Greek colonies of Abdera and of Emporion by same cultural group, the Ionian tribe. An innovative approach combining multi-proxy palaeoecological analyses (pollen, non-pollen palynomorphs, plant macroremains, high-temporal fire reconstructions), and Landscape Archaeology datasets will be applied in both areas to reconstruct changes in vegetation, land-uses and landscapes following prehistoric migratory processes and colonial settling between the 6th millennia cal BC and the 4th century AD. A particular focus will be put in reconstructing landscape changes following Graeco-Roman colonial settling to assess 1) common and diverging trends in land-use and landscape shaping in culturally similar colonial landscapes over long distances, and 2) the interaction, integration and resilience of autochthonous and colonial practices and landscapes across the Mediterranean.

Mots clés : palaeoenvironment, landscape archaeology, transported landscapes, human migrations, ancient colonization, palynology, fire history, mediterranean, greece, spain

Participants :
- Université de Montpellier (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
- Institut Català d'Arqueologia Clàssica (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet SHOCKWAVE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Plasma shocks are ubiquitous phenomena in space plasmas, emerging when a supersonic and super-Alfvénic plasma flow encounters an obstacle. The solar wind is such a flow with usually high Mach numbers. Solar wind shocks occur due to two obstacles: magnetic fields of planets or much slower solar wind in front of it. The Mach number dictates the shock strength: from strong (roughly > 5) to weak (1-4).  Spacecraft in Earth’s environment allowed us to study the terrestrial shock as an example of a strong shock in increasing detail in the past decades. The availability of shock measurements from other planets is increasing as well. However, most astrophysical shocks are weak, in particular shocks that have little to no in-situ measurements. The lower range of Mach number shocks is underexplored, especially with high resolution data (resolution of several seconds to milliseconds).  Our main goal is to utilize state-of-the-art spacecraft data to explore the lower Mach number range of shocks (including wave activity, jets, instabilities) and crosscheck the universality of our results with available events in the solar system. To tackle this project, we propose a 3-step analysis: 1) Comparing low and high Mach number range at the terrestrial shock, 2) Investigate interplanetary shocks using high-resolution data, and 3) Providing a comprehensive study on the transition of characteristics from low to high Mach number values.  The proposed research will be carried out in a 24-month project at the Queen Mary University of London. This institution hosts well-known international experts on shock physics and space plasma physics, providing outstanding expertise that perfectly matches the proposed efforts. The generated knowledge will deepen our understanding of shock physics with application throughout the solar system as well as general astrophysics. In particular we will apply the knowledge on interplanetary shocks, which are the precursor of strong geomagnetic storms at Earth.

Mots clés : bow shocks, weak shocks, interplanetary shocks, space plasmas, magnetosheath, solar terrestrial relations, inteplanetary plasma, coronal mass ejections, stream interaction regions

Participants :
- Queen Mary University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet POLARCLIMATE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Addressing climate change's existential threat demands a global effort to rapidly reduce carbon emissions. However, political gridlock fuelled by societal polarisation can stymie effective action. POLARCLIMATE confronts this challenge, studying interventions to curb climate scepticism and foster consensus.  POLARCLIMATE will use a social media lens to advance the current state-of-the-art on climate polarisation, tackling three key research challenges. First, existing studies of climate polarisation fail to consider how passive engagement with climate narratives shape climate opinions. Second, studies of climate polarisation are typically siloed to a single platform, limiting their demographic relevance and preventing a robust cross-platform analysis of content and structure. Finally, studies do not adequately consider the agents who drive climate polarisation, especially those organisations with a vested financial interest in maintaining the status quo. To address these challenges, POLARCLIMATE will take an interdisciplinary, multi-modal approach drawing on quantitative methods from networks and data science, and qualitative methods from climate communications. The analysis of passive consumption and cross-platform structure will be studied using Bayesian inference and network reconstruction methods, and content will be analysed using taxonomies of climate scepticism and computer-aided topic modelling across various climate publics. Finally, organisational financial interests will be identified by using Bloomberg financial data, and compared to the rhetoric of corresponding organisations on social media.  POLARCLIMATE will balance scientific rigour with policy relevance. The project's outputs will offer multi-modal evidence to inform the development of concrete policy recommendations aimed at mitigating the adverse impacts of climate polarization. These recommendations aim to contribute to a more unified and effective global response to climate change.

Mots clés : network science, social media, climate change, political polarisation, social networks, misinformation, disinformation, statistical inference, climate denial, climate scepticism, multilayer networks

Participants :
- University College de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Europe centrale (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183600.96 €
Projet MEEHIL (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This research project aims to study the entanglements and discrepancies between indigenous understandings of history and colonial narratives created by missionary intervention amongst the Shuar people of lowland Ecuador. It will examine how history, indigenous memory, and cultural transmission have been developed and produced in the context of missionisation and colonial pressure. It aims to understand how colonial history still impacts indigenous politics today, shaping current indigenous engagements with large-scale resource extraction and allowing extractive capital to endure and perpetuate over time. To achieve these objectives, this research reviews the historical archives available in the region from the Salesian and Franciscan missions since the late 19th century, will collect and archive film footage of testimonial memories from indigenous participants on their complex relationship with the missionary endeavours and boarding schools, and will map how missionary presence shaped indigenous land. The use of these three different methodologies will be combined to provide a clear ethnographic study that aims to understand and describe the long-term effects of colonial entanglements on people’s attitudes, thinking, and current political developments. Overall, this research project is concerned with colonial residues and proposes to look at land demarcation, history, and cultural transmission to understand not only the impacts of colonialism in its tangible political ubiquity but also in its pervasive and intangible influence over concepts that help people define their worldview.

Mots clés : colonization, social change, boarding schools, history, indigenous memory, missionary archives

Participants :
- Université d'Europe centrale (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199440.96 €
Projet BAME (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

BAME is a project in applied mathematics addressing challenges in the kinetic theory of gases. The focus is on a system of Boltzmann-like equations that describes gas mixtures composed of monatomic and polyatomic gases. Evidence has shown that kinetic models accurately describe strong nonequilibrium processes in gas flows. However, most of the mathematical theory is limited to the oversimplified case of a single monatomic gas. This project aims to contribute in filling the gap between the study of more intrigant gases relevant to applications and the current state of the art in the mathematical theory of kinetic equations. Specifically, the objectives are to study the regularizing effects of the associated Boltzmann operators, as well as the integrability and smoothness of solutions, with the ultimate goal of analyzing the large time behavior using quantitative entropy methods. The project will bring together the applicant with a distinguished expertise in modelling and analysis of polyatomic gases and mixtures at the mesoscopic level and the host with a ground-breaking work on entropy methods for macroscopic reactive systems. The two levels of description will be formally linked through hydrodynamic limits during the secondment, leading to a redesign of the entropy production program for the system of interest. The fellowship will enable the applicant to gain new analytical skills and significantly enhance transferable skills through the extensive training offered by the host University of Graz. Additionally, it will greatly expand her research network, facilitate participation in leading events in the field, and ultimately strengthen the ability to establish her own research group and advance her career in academia.

Mots clés : kinetic theory, system of boltzmann like equations, polyatomic gases, multi component gas mixtures, entropy methods, integrability propagation, regularity propagation, hydrodynamic limits

Participants :
- Université du Minho (Portugal) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Graz (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230184.72 €
Projet MARCH-ON-DIGIT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

"Memory and Archive Ontology in Digitalization of War Heritage in the Western Balkans" (MARCH-ON-DIGIT) project aims to investigate the intersection of memory and archive in the context of digitalization, focusing on the 20th century war heritage in the Western Balkans (WB). The project examines this ontological relation through the lens of institutionalized remembering within WB memory institutions, such are libraries, archives, and museums. By addressing it the project offers a fresh perspective on the impact of digitalization on memory preservation and transmission. It will be conducted at the Centre for Southeast European Studies, University of Graz, by an experienced researcher in digital humanities and cultural studies, in collaboration with a team of established experts in history, international relations, digital research methods and technologies. The project proposes a groundbreaking exploration of the intricate ontology between Europeanization processes, memory, and archive in the context of digitalization and preservation of digital heritage. It aims to unravel the complex influence of heritage digitalization on remembrance practices in the digital age. MARCH-ON-DIGIT addresses a critical gap in the scientific community's understanding of digital heritage preservation related to conflicts. The project's innovation is also amplified by its focus on the WB region, where a turbulent history of recent conflicts profoundly shapes current political and historical narratives. This research is particularly relevant and timely as the region nominally strives for transnational unity within the processes of Europeanization, but progress lacks which creates internal tensions, which this project will evaluate from the cultural memory and digital heritage theoretical approaches. By critically investigating this topic from both national and international perspectives, the project will serve as a pioneering reference for similar research in the broader European context.

Mots clés : digital heritage preservation, europeanization, western balkans

Participants :
- Université de Graz (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230184.72 €