Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet COLDmicroWAVE (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

COLDµWAVE aims to improve the research skills of Epameinondas Xanthakis by developing an innovative environmentally sustainable process for blanching and freezing vegetables with improved textural and nutritional quality at SP -Technical Research Institute of Sweden. The study which will be carried out will involve the use of microwave electromagnetic irradiation (MW) for blanching and freezing of vegetables. COLDµWAVE will develop tailored equipment for MW blanching of vegetables that has very high energy efficiency and no water consumption. Furthermore, this project will develop innovative pathways in freezing to improve the quality of frozen vegetables by exploring, in a new context, previous results acquired by the fellow. The developed process will lead to improved quality characteristics compared to the conventional freezing. During this extensive study the fellow will gain valuable multidisciplinary experience and new theoretical and practical skills in the areas of heat transfer modelling, energy accounting methods, food nutrition and quality measurements as well as life cycle assessment methods. The integrated proposed study will give the fellow the opportunity to develop further knowledge on development of innovative processes having industrial importance and finally become a real specialist in the microwave assisted food blanching and freezing. The candidate will also learn to conduct research, to manage projects, communicate results effectively, commercialise research, as well as an in-depth education in development of innovative processes which will contribute for an open mind to innovation and more successfully realisation of research ideas into commercial reality.

Mots clés : vegetables, blanching, freezing, microwave, modelling, kinetics

Participants :
- RISE Research Institutes of Sweden (Suède) — Coordinator, beneficiary, Recherche, subvention : 173857.2 €
Projet CONDISOBS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

CONDISOBS aims to strengthen the professional profile of the researcher through the design, management and implementation of an individual research project, as well as through advanced training in research methods and transferable skills. The project will provide a unique and comprehensive analysis of the three key measures that were undertaken after the “refugee crisis” to govern asylum seekers’ mobility in the EU, which is to say hotspots, relocation, and border controls. More specifically, it aims to understand whether hotspots have succeeded in containing incoming migrants in the first country of entry and whether relocation schemes and the strengthening of border controls have reduced “secondary movements” of asylum seekers within the EU. This will be achieved through an extensive, multi-sited qualitative study focusing on three aspects. The first concerns the functioning of hotspots in Greece and Italy and their ability to register all incoming migrants and channel them to the relevant administrative procedure. The second relates to the practical difficulties encountered by Greek and Italian authorities to relocate people, as well as the trajectories of those who were relocated to Luxembourg and Lithuania. The third deals with the effects of the reintroduction of border controls in three strategic border points that are commonly used by migrants to leave Italy (Bardonecchia, Brenner, and Ventimiglia). With its findings, the study will contribute to current debates on the reform of the Common European Asylum System by providing policy recommendations based on solid empirical evidence, which will be communicated through a comprehensive dissemination plan targeting both academic and non-academic audiences. Thanks to its manifold focus on research, training, project management and dissemination, CONDISOBS will thus represent a key stage in the career of the researcher, while also broadening the research base and networking opportunities of the host institution.

Mots clés : critical migration studies, eu asylum regime, hotspots, relocation, dublin regulation

Participants :
- University of Luxembourg (Luxembourg) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166320.0 €
Projet CVELANG (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

CVELANG adds to growing literature on the increasing prevalence of CVE (Countering Violent Extremism) measures in public life by innovatively examining how learners of language and language education centres deal with policies that cohere to wider governmental, security objectives relating to integration in Denmark and the UK respectively. The integration of migrant communities through the controversial ‘ghetto’ policy in Denmark, which targets socially and linguistically segregated areas, and the Prevent program in the UK demanding educators detect and report those demonstrating signs of radicalisation. CVELANG investigates language teaching in Danish ‘ghettoes’ as well as Prevent in relation to language centres. CVELANG explores how such policies are implemented at a ground level through an ethnographic approach. There are three perspectives to this project: (1) Muslim learners and (2) teachers and (3) management who mediate policy. Little is known about the influence of such policies in adult migrant educational settings which this project will address by centering the experiences of those involved in policy implementation. This allows for space to narrate and define bottom up notions of security and integration and how language-security policies influence ordinary people and institutions in their relations with each other, the state and the national language.

Mots clés : security, language learning, immigration, countering violent extremism

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 219312.0 €
Projet CaPer (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

CaPer is an ambitious interdisciplinary project exploring how forms of play and recreation helped shape and sustain the Catholic minority in Protestant England. In faith-divided early modern Europe, the English state persecuted Catholics for their religious allegiance, excluding them from political life. How did the marginalized Catholic minority, navigating between opposition and loyalty to their Protestant monarchs, survive in such a hostile environment? Exploring issues of religious intolerance, inequality, and social exclusion, CaPer adresses one of the main challenges for the future of Europe. Studying the English Catholic community from an innovative perspective, it examines sources and practices which historians have hitherto rarely considered. It breaks new ground by comprehensively investigating how Catholics built communal bonds and negotiated their place in English society through theatre, dance, music, sports, and ceremonies throughout the period of the most vigorous religious persecution, from the accession of Elizabeth I in 1558 to the restoration of the monarchy in 1660. Tapping into underexplored archives in order to collect and analyse a vast quantity of neglected records of performance, and paying attention to both microcosms within provincial Britain and international networks of global Catholicism, CaPer will: a) produce a new cultural history of the English Catholic community, demonstrating how performance played a crucial role in education, sociability, missionary activity, private devotion, and in maintaining Catholic social standing; b) introduce to historiography previously neglected practices and actors, including women players, dancing masters, music teachers, and itinerant entertainers; c) expand our knowledge of practical religious coexistence in the early modern period, providing a blueprint for future studies of play and leisure among religious minorities, and inform contemporary European policies aimed at reducing social exclusion.

Mots clés : performance, early modern theatre, entertainment, ritual, ceremony, hospitality, religious coexistence, english catholic community, catholic mission, transnational exchange, social networks

Participants :
- University of Toronto (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 235490.4 €
Projet EPIC (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Calcification by marine organisms can be drastically affected by ocean acidification (OA) due to a reduced availability of calcium carbonate in seawater. Planktonic gastropods (pteropods and heteropods) are believed to be among the most vulnerable organisms to OA as they live at the ocean surface and build thin shells of aragonite. Shelled pteropods have received considerable attention and are reported to decrease calcification rates and experience shell dissolution under high CO2 conditions. Shelled heteropods have received much less attention, but are expected to be equally vulnerable. However, the vulnerability of planktonic gastropods is based on short-term exposures to extreme OA conditions. The aim of the proposed project is to study the evolution of calcification in planktonic gastropods and assess its evolutionary potential under OA. Planktonic gastropods build shells through a biomineralization process, controlled at the molecular level, but the genes underlying this process are unknown. Using shell proteomics will enable to identify for the first time the biomineralization genes in pteropod and heteropod species. Next, these genes will be used to understand how biomineralization evolved in the two independent plankton groups over long and short timescales. Over long timescales will include building solid macro-evolutionary frameworks using fossil-calibrated phylogenomic trees and analysis of the evolution of biomineralization genes. Over short timescales will involve studies at the population-level by measuring gene expression under past, present and future concentrations of CO2. The proposed action will allow the discovery of new molecular markers to investigate the impacts of OA. Combining macro- with micro-evolutionary approaches will shed light on the processes that drive diversity and evolution of calcification in planktonic gastropods and will allow more realistic predictions of the consequences of global change on marine calcifiers.

Mots clés : zooplankton, ocean acidification, biomineralization, calcium carbonate, macroevolution, proteomics, adaptation, next generation sequencing

Participants :
- Naturalis Biodiversity Center (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 175572.48 €
Projet LIVING LASERS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Can a living cell be turned into a laser? By aiming to coalesce biological cells with laser light, the most versatile tool that modern photonics has developed, LIVING LASERS explores entirely new ways to develop fully biocompatible lasers. The ability of vitamins, bacteria and even living cells to generate laser light has been recently demonstrated by the supervisor of the project, Prof Malte Gather. However, these and other experiments with active biological gain media are so far limited by the rigid and synthetic nature of the optical resonators, an essential part of any laser device. Introducing lasing in living cells independent of external resonators necessitates a conceptual change of the laser design. This is realized by internalization of microscopic resonators that will transfer the optical feedback directly into the cell. It is the main goal of this interdisciplinary project, located at the interface between material sciences, laser physics, photonics and biology, to demonstrate autonomous single cell lasing. Consequently, LIVING LASERS can be expected to start a whole new field in biophotonics and will help to overcome the boundaries between living nature and nowadays highly artificial and harmful laser technologies.

Mots clés : biocompatible laser, structural colour, natural resonator, polymer resonator, endocytosis

Participants :
- University of St Andrews (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet CanFaster (Horizon 2020, appel à projets 2016)
Action : Cofund Doctoral programme
Statut du projet : CLOSED

CanFaster is a joint venture among industry, health care and academia to enhance and accelerate innovations and clinical implementation within oncology. The vision of CanFaster is to prolong and save lives of cancer patients through integrated development and commercialization/implementation of diagnostic/treatment alternatives, thus reaching the market and patient more rapidly. CanFaster will save lives of cancer patients, not for future generations, but for today´s. The CanFaster programme is enabled by an intimate collaboration between industry, health care system and academia (in total ~7 million Euro will be invested), and will contribute to the Europe 2020 strategy, where one million new research jobs are needed to reach the Innovation Union flagship initiative. The collected track record of all partners in the proposed CanFaster programme demonstrates an impressive history of entrepreneurial spirit, state-of the art medical care but also truly world-class scientific excellence within translational cancer research. The CanFaster regional doctoral programme, recruiting 16 ESRs, will be hosted within CREATE Health, a translational cancer research programme with broad international collaboration partners and excellent out-put for the last 10 years. Main objectives of CanFaster are (i) Increased transnational and intersectorial mobility (ii) Intersectorial improvements through intensified collaboration within oncology between academia, industry and hospital/regional health care organisations. (iii) Acceleration of innovation, attracting international investors leading to increased number of SMEs in the region and (iv) Education of a new generation of excellent multidisciplinary, entrepreneurial scientists. This is achieved through the attraction of the MSCA program for industrial partners to add-on to the EU and public national funding of the programme with financial and in-kind contribution.

Mots clés : cancer research, cross disciplinary, triple helix, advanced technologies, clinical implementation, life science, intersectoral, innovation

Participants :
- Lund University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1674240.0 €
Projet UTILIUM (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cancer Immunotherapy is the latest breakthrough in the fight against cancer, especially with the successes of checkpoint inhibitors. However, numerous tumors appear non-responsive, including uveal melanoma (UM) despite its shared cellular origin with cutaneous melanoma. In this project, I propose to study the immune landscape of UM and explore strategies to overcome mechanisms detrimental to the antitumor immune response. I will employ highly innovative technologies from the fields of genomics, immunology and bioinformatics to explore the tumor microenvironment. Gene expression profiles of UM metastases and neoantigen presentation will be obtained by RNA sequencing. The functional expression of multiple immune markers will be analyzed by cutting-edge multispectral immunohistochemistry to determine immune cell subset presence in a qualitative and quantitative manner. The obtained knowledge will subsequently be used to test and improve reactivity of tumor-infiltrating lymphocytes in an autologous model. These experiments require optimal expansion of tumor-infiltrating T cells, which is highly developed at the laboratory of prof. Svane at the Center for Cancer Immune Therapy at the Herlev Hospital in Copenhagen, Denmark. I expect that this project will provide a more complete overview of the immune landscape of UM and reveal important mechanisms underlying immune suppression in UM. The findings of this project could pave the way to the clinical development of successful immunotherapeutic strategies for the treatment of UM and potentially other tumor types resistant to immune checkpoint inhibitors. Finally, this project will improve my laboratory and leadership skills, greatly improving my chances of achieving the next goal in my career: a permanent position as an Medical Oncologist with my own lab-based group in the expanding field of Cancer Immunotherapy to accelerate the application of translational research into the clinic.


Participants :
- Capital Region of Denmark (Danemark) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 200194.8 €
Projet ProCenDecl (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Cancer cells have the tendency to accumulate extra copies of centrosomes, organelles responsible for the microtubules' organization during cell division. In normal cells, an aberrant number of centrosomes leads to the formation of multipolar spindles, uneven segregation of chromosomes between daughter cells and consequent mitotic catastrophe. On the contrary, cancer cells are able to form a pseudo-bipolar mitotic spindle by a process called centrosome clustering, which provides survival advantage for tumor cells. The specificity of this process can be exploited as a potential novel target for the development of highly selective anti-cancer drugs. The mechanism of centrosome clustering is not completely understood. Particularly, from recent reports it seems that ADP ribosylation factors tankyrase (TNKS1) and ADP-ribose polimerase 16 (PARP-16) have a significant role in the prevention of multipolar spindle formation. Based on these findings and the already druggability of poly (ADP-ribose) polymerase (PARP) enzyme family, a SAR study on phtalazinone PARP inhibitors from AstraZeneca's compound library was carried out. This study led to the discovery of AZ9482, a potent inhibitor of centrosome clustering, and AZ0108 an orally available derivative that is able to potently inhibit PARPs 1/2/6. AZ9482 as well as AZ0108 can be used as a starting point to design and synthesize a first series of chemical proteomics tools, that will allow an extensive investigation of the centrosome declustering mechanism. All currently available technologies in the field of target discovery will be employed, including photoaffinity ligation and biorthogonal conjugation. The acquired knowledge can be used to design novel highly specific and potent anti-cancer drugs that inhibit centrosome clustering with a specific mode of action.

Mots clés : centrosome clustering, activity based probes, photo affinity ligation, bioorthogonal conjugation, proteomics

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet SCAR (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cancer complicates 1 in 1000 pregnancies representing an important health challenge that affects both mother and child. In a series of breakthrough clinical studies, the hosting lab has shown that chemotherapy given during pregnancy is relatively safe for the infants in the short term. However, children born after in utero exposure to chemotherapy are often small for their gestation age, present with lower IQ scores and have higher risk to wear glasses, suggesting possible long-term health effects. Because chemotherapy elicits (epi)genetic alterations to cancer patients, we hypothesize that chemotherapy-mediated long-term health effects could be due to (epi)genetic changes in the offspring of women treated with chemotherapy during pregnancy. Thus, SCAR aims to determine whether in utero exposure to carboplatin may be linked to DNA damage in the offspring. My objectives are to 1) identify the genetic damage at single cell level and 2) determine epigenetic modifications; in umbilical cord blood cells of children in utero exposed to carboplatin. To this end, I will integrate highly innovative sequencing techniques and the access of the hosting team to a unique registry of pregnant cancer patients. As the phenotypic expression of these genetic alterations could take decades to appear, studying the underlying molecular epi(genetic) changes at birth, will provide more immediate evidence than long-term clinical follow-up, and will be instrumental to define safe and solid treatment guidelines for pregnant cancer patients. Through this work, I aim to broaden my scientific expertise (including technical and transferable skills) and my international network for pursuing an academic career in Europe. The MSCA-IF will be instrumental to actualize many objectives outlined in my career development plan in order to become an independent researcher in the genetic oncology field.

Mots clés : oncology, genetics, breast cancer, chemotherapy, epigenetics

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 178320.0 €