Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CHICC (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

CHICC aims to understand the impact of climate-change driven heritage loss on local communities. The widespread impacts of climate change are acknowledged in the UN’s Sustainable Development Goal 13: Climate Action; however, the full scale of the impacts on heritage and associated communities is currently unknown but knowable. Three damaged or lost heritage sites will be explored through CHICC: Mårup, Denmark; Dunbeag, Ireland; Brora, Scotland. Each has been altered by climate change, creating an impact on the lives and livelihoods of local communities, their sense of place and belonging, their perception of climate change; overall, impacting their cultural identities. As North-West Europe is expected to experience greater and more widespread heritage loss due to climate change, CHICC will use these sites to understand the complexity of loss, and the impact on communities and their cultural identities. Through adopting a Citizen Science approach, CHICC will include the often-omitted voice of local communities to understand how climate change impacts them, which may include an upsurge in engagement with climate change mitigation, greater energy for preservation or forgetting. Communities will be active participants within the research, contributing their views, ideas and resources. Through co-creation, CHICC will launch an online, deepmap for three damaged or lost heritage sites. The deepmap will collate and democratise multidisciplinary, primary and secondary data to interrogate the relationship between climate change, heritage and culture. This open-access resource will be created in-line with a Digital Preservation Strategy to ensure reuse of data for future researchers and varied stakeholder groups. The methodology developed includes co-creation and Citizen Science, underpinned by well-integrated interdisciplinarity, thus allows for impact and relevance for the numerous stakeholder groups with vested interested in heritage, climate change and the future.

Mots clés : climate change, deep mapping, heritage loss, citizen science, co creation, interdisciplinary, local communities, climate change impacts

Participants :
- Aarhus University (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 207312.0 €
Projet CHILDCIPH (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

CHILDCIPH proposes a two-year fellowship at the School of Arts and Communication (K3) at Malmö University, Sweden. The recent rise of illiberal, conservative and right-wing populist movements poses an acute threat to democracy and equality in Europe. One pervasive but underresearched strand of these movements advocates ‘traditional family values’, in particular conservative sexual and gender politics, in the name of protecting children. The project will fill this research gap through interdisciplinary research examining the discursive construction of the child as the ultimate site of vulnerability and risk, and hence in need of protection and policy intervention. The irrational, or affective component of such discourses calls for an approach capable of accounting for their emotive force or ‘grip’. This proposal aims to develop such an approach, combining insights and methodology from political discourse theory, media studies and psychosocial studies. The research is characterised by a significant comparative dimension, analysing discourses by conservative, ‘pro-traditional family values’ actors, from politicians to activists, in Germany and Russia. The project will generate 3 articles and will be presented at international conferences, through blog posts, public events, as well as policy recommendations. The host institution will benefit from an interdisciplinary project that operationalizes the role of emotions and affect in media research – an aim central to the work of the Rethinking Democracy research platform, while it will benefit my career trajectory by establishing me as an independent researcher with a unique and thorough expertise on the role of emotions and affect in analyzing processes of negative political mobilization, in particular in issues threatening gender equality and LGBT rights.

Mots clés : anti gender movement, discourse, affect, russia, germany, psychosocial, heteroactivism

Participants :
- Malmö University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191852.16 €
Projet CLOE (Horizon 2020, appel à projets 2020)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

CLOE will be an interdisciplinary and inter-sectoral Doctoral Programme developed and coordinated by the University of Genoa, as sole beneficiary, in collaboration with a network of host academic and non-academic organisations. UNIGE will recruit 15 Early Stage Researchers (ESRs, no PhD and less than 4 years FTE research experience), respecting mobility rules of MSCA. CLOE training is focused on multidisciplinary approaches to mountain and rural sustainable development and conservation starting from historical, environmental and legal perspectives. It will support top-tier ESRs working on 4 closely related topics: mountain areas and heritagisation processes (T1); mountain conservation, cultural landscapes and conflicts (T2); coming back to the mountains (T3); mountain areas and environmental risks (T4). The 15 ESRs will be enrolled in 11 doctoral courses involved in CLOE through 2 calls for applications: the first cohort of 7 ESRs will start on November 1, 2021, while the second of 8 ESRs on November 1, 2022. A rich and diversified range of training opportunities will allow to broaden the cross-sectoral and interdisciplinary skills of a new generation of early-stage researchers (ESRs) and provide a common ground for their future careers and for new research paths with important implications for sustainable development and environmental and cultural conservation. UniGE, the university of Liguria, with campuses in the major cities of the Region and one of the most important of Northern Italy, is particularly qualified to conduct CLOE due to the previous and on-going projects of the involved supervisors. The doctoral programme will make it possible to network existing doctoral schools that deal with subjects related to mountain areas from different perspectives, and will be the first step in the development of a new Strategic Centre on Mountain and Rural areas (MORA) that will deal with their new centrality.

Mots clés : training, mountain and rural areas, locally based and socially fair sustainable development, historical perspective, environmental risk, territorial management, cultural and natural heritage

Participants :
- University of Genoa (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1220400.0 €
Projet COATING (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

COATING aims at developing cutting-edge technology for the reduction of stent thrombosis and restenosis events, based on a multidisciplinary approach linking fluid mechanics and biomedical engineering. Principles of fluid mechanics will be combined with nanotechnology to advance our understanding of the physics of drag reduction and exploit this to establish a novel biomedical engineering application. The nanotechnology is based on magnetorheological fluids, also called ferrofluids (FFs). Specifically, FFs will be used as a lubricant for the reduction of harmful wall shear stresses generated at the coronary stent surface. The objectives are, firstly, to evaluate the performance in terms of magnetoviscous effects of various biocompatible FFs varying shear and magnetic field strength. Secondly, we will evaluate the FF-based drag reduction by performing extensive FF-coated pipe flow experiments. Finally, we will evaluate the efficiency of the novel drag reduction technique in stents in vitro. The project will be hosted at WSL, Switzerland, which is part of the ETH domain, a world leading and closely cooperating network of research institutes, and will be integrated in a young and dynamic research group, offering a cutting-edge laboratory and excellent opportunities for career development. The proposed technology strives to complement or even replace adjunctive pharmacological treatments usually adopted after stent implantation, which often have significant harmful side effects. It has the potential to improve the quality of life of the millions of patients worldwide that undergo coronary stenting each year, and to provide a new solution for patients in which pharmacological therapies cannot be prescribed. Finally, the project results are also expected to foster other applications of FFs in the bio-engineering medical field and to develop a new drag reduction technology applicable in other research areas (e.g., oil pipe industries) that seek to reduce energy consumption.

Mots clés : drag reduction, ferrofluid, fluid mechanics, hemodynamic, shear stress, rheology, bio fluid dynamics, biomedical engineering, lubricant, slip condition, pulsatile flow, blood flow, magnetoviscous

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Recherche, subvention : 203149.44 €
Projet CONGOTOPIA (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

CONGOTOPIA proposes a new approach to the historical phenomenon of decolonization. Built on a rich bibliography in history, anthropology and sound studies, this project examines the movement of people, ideas and music put into motion by the Pan-African appeal of Congolese rumba. Inspired by early Afro-Cuban records, this dance music emerged in 1940s Leopoldville (current-day Kinshasa) and Brazzaville and soon became Africa’s most influential popular style thanks to the development—unique to Africa—of local radio stations and recording companies. Across different territories yearning for their independence, Congolese sound inaugurated a utopic Africa, audible over various Afro-Cuban rhythms and multi-voiced harmonies mixing Spanish with various African languages. While closely associated with pleasure, romance and fantasy, this popular music became a powerful marker of decolonization—in the 1960s, it “inflamed” Angolan nationalists’ spirit during the liberation war while allowing great Brussels-based musicians such as Manu Dibango to “jump in feet first with the question of Africa.” Examining the global, trans-imperial geography of Congolese rumba between Cuba, West Central Africa and Europe will reframe the conception of decolonization and the movements through which it unfolded in the period 1930-1974. By straddling the traditional divide between Francophone and Portuguese territories while reconnecting the African continent to the Southern Atlantic, it challenges established approaches to decolonization and sheds light on the history of a space (West central Africa) and from a perspective (colonized people’s) that have long been marginalized in the field of African studies. As the Congo(s) and Angola are impossible to fully dissociated from their multi-layered relations with Cuba in the period 1930-1974, the study of this musical region will deepen or understing of the Global South from an African perspective.

Mots clés : sound studies, radio studies, history of african music production, pan africanism

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 257619.84 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SHIFT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

COVID-19 severity and mortality are consistently higher in men than women. Still, the mechanisms that underlie sex differences in human antiviral immunity remain poorly understood. Therefore, investigating sex-specific regulation of immune responses is a critical step for developing novel and effective antiviral therapies. The overarching goal of SHIFT is to dissect the precise contribution of sex hormones to human antiviral immune function by studying the immune system of individuals as they undergo sex-reassignment therapy with sex hormones. The three specific aims proposed are 1) to evaluate the sex hormone contribution to viral infection susceptibility, 2) to characterize sex hormone effects on the immune-microbe interactions and balance, and 3) to assess sex hormone effects in antiviral immune responses during infection. SHIFT will combine the experienced researcher’s advanced knowledge in sex hormone regulation of immune function and metabolism, with the host lab’s state-of-the-art multi-omics technologies, advanced expertise in systems immunology analysis and established collaborations in Sweden. Aims will be achieved during a planned 24-month training at Karolinska Institutet that involve technical training (sample collection and processing), analytical training (integrative computational analysis and statistics), and development of transferrable skills (project management, mentoring, leadership and communication). The two-way transfer of knowledge in SHIFT will lead to implementation of new techniques, mentoring of trainees, and identification of sex-hormone regulated pathways in antiviral immunity that will be valuable for vaccine design, antiviral therapies and immunomodulatory therapies at large. Further, the MSCA fellowship will provide a strong training path in systems immunology to lead the fellow towards academic independence in the EU and support her career goals of becoming an investigator studying immunological basis of disease susceptibility.

Mots clés : immunology, human immunity, immune function, sex differences, sex hormones, systems immunology, viral infection, antiviral immunity, antiviral immune responses

Participants :
- Karolinska Institutet (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191852.16 €
Projet anti-CRISPR (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

CRISPR-Cas immune systems protect bacteria against their viruses (phage). However, some phages encode anti-CRISPR (Acr) genes that block CRISPR-Cas activity. While the molecular understanding of Acr activities and structures are racing ahead, their impact on the ecology and evolution of phage/bacteria populations remains unexplored. I first aim to identify the ecological factors that influence the selection for Acr genes, to explain why some phages encode many Acr whereas most encode none. Next, by running long-term co-culture experiments, I will examine whether CRISPR-Cas can evolve to escape Acr inhibition and whether Acr genes can reciprocally adapt to restore activity. These experiments will reveal how CRISPR-Cas and Acr coevolve and allow to mathematically predict the long-term stability of Acr activity. I will also explore the genetic bases of this coevolution through deep-sequencing analyses. This multidisciplinary project combines my expertise in phage biology, that of the host in experimental evolution and bioinformatics and that of collaborator in mathematical modelling. It is expected to open new avenues of research for downstream medical and bioengineering applications. This high-quality 'training-through-research' will allow me to widen my scientific expertise, develop essential complementary skills and constitute an international collaborative network. The visibility and impact of this research will be increased by a strong dissemination and communication plan. I also aim to reinforce my public engagement activities with a dual objective of making science accessible for everyone and inform about phage research. Carrying out this project within the Centre for Ecology and Conservation at the University of Exeter (EU accredited), a top department in ecology and evolution worldwide, and under the supervision of two world leading scientists in their fields, will be crucial for the development of my career as an independent European researcher.

Mots clés : bacteriophage, co evolution, crispr systems

Participants :
- University of Exeter (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet CROSS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

CROSS is a project of an experienced historian of “Research Freedom” in Religious Studies. 7 years ago, he entered the forum of discussions in Central and Eastern Europe, which reveals itself as particularly vibrant today. Now, he seeks to launch a major project located at the University of Olomouc in Czech Republic, next to a leader of this debate. CROSS is also a project of an historian who, after 3 decades of research, feels the limits of academic barriers, and wants to move over the borders of the scholarly studies. The acronym means “Communication for ReligiOus StudieS”. CROSS aims to reach out, to improve public understanding of Religious Studies by the way of a documentary film. The project is located at the University that hosts the major Science Documentary Festival in Europe. After a period of training in Film Studies and Media Studies, a collection of interviews of 30 scholars in 10 countries in Central and Eastern Europe will be recorded in order to let the free voice of Religious Studies scholars be heard. CROSS will use personal story-telling on the topic “Freedom of thought and expression” which shall serve as life lessons, not academic lessons. It will explore how personal, not strictly scientific experiences, even of public concern in everyday life, can become stories to which people can relate to and through which connections can be established and awareness raised. The project will involve students in training-workshops for processing the documentary, and for laying the basis of a laboratory for future research. CROSS addresses the first principle of the European Charter for Researchers: “Research Freedom”. It is an interdisciplinary project for a new research profile “Communication for Religious Studies”: a new way to communicate research, an innovative guidance, and the first-ever documentary on Religious Studies.

Mots clés : research freedom, science documentary, central and eastern europe

Participants :
- Palacký University, Olomouc (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 156980.64 €
Projet CYBERCULT (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

CYBERCULT is a project that examines why and how western states are developing Offensive Cyber Capabilities (OCC): human, technical and virtual tools to disrupt, destroy and exploit computer systems. CYBERCULT has three core objectives. First, it will establish a Strategic Culture-based theoretical concept that explains the development and use of OCC by western powers. This concept will move beyond rationalist and materialist explanations of OCC processes and consider the influence of Strategic Culture on OCC adoption, including the socio-political, historical, and perceptual/ideational factors involved. This will be achieved through a theory-building phase involving an Interdisciplinary Workshop on OCC, a literature review on Strategic Culture and new technologies, and sustained interaction with leading Strategic Culture academics. Second, CYBERCULT will produce a data set on perceptions of OCC in eight countries that are connected to the western alliance system: the US, Israel, France, Germany, the UK, Estonia, Japan and New Zealand. The data set will be based on an analysis of surveys sent out to cyber policymakers and practitioners in the eight countries. Third, CYBERCULT will produce an in-depth comparative analysis of OCC adoption in three of the world's leading cyber powers: the US, Israel, and France. This will be based on primary and secondary sources and twenty interviews with scholars, government officials, and cyber industry representatives in each of the three countries. CYBERCULT will have sustained links to policymaking and industry and will help to inform fast-moving cyber security processes in the EU and NATO, including the EU Cyber Security Strategy and NATO Cyber Defence Policy. CYBERCULT will be hosted by Recherche et Etudes en Politique Internationale (REPI), Université Libre de Bruxelles (Belgium). The key deliverables are a journal article, a book, three policy briefs, and two working papers.

Mots clés : cyber security, cyber warfare, strategic culture

Participants :
- Université Libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166320.0 €
Projet TARGETSS (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cancer can be considered a disease of gene control; since dysregulated patterns of gene expression are a feature of all tumours. Excitingly, targeting the underlying epigenetic mechanisms that promote oncogenic gene expression in cancer cells is providing significant opportunities for cancer drug development. Indeed, initial successes in this area may soon be leveraged for the benefit of cancer patients. Expanding European research capabilities in this area is essential, since approximately 1.5 million people die from cancer each year in Europe; and projections indicate that this number will increase in the coming decades. The work described in this application is at the cutting-edge of cancer drug target discovery, and drug development. My work identified the SWI/SNF complex component BRD9 as a novel drug target in several malignancies; and drug development efforts have led to first-in-class BRD9 degrader compounds. Testing the in vivo efficacy of these novel compounds as anti-cancer agents (WP1) will be essential if we are to translate these compounds to clinical investigations. Moreover, the work described in WP2/3 will be essential to fully exploit the potential of BRD9 as a drug target and identify additional opportunities for future drug development. My expertise in the areas of epigenetics and drug development make me the ideal candidate to pursue the outlined research program. Moreover, the support of this Action will give me the opportunity to develop further as an independent researcher; both in terms of technical expertise and transferable skills. These additional skills will allow me to achieve my long-term career goal of establishing my own independent research program, focusing on cancer epigenetics/drug development within a European context. Dissemination of the research findings associated with this Action will increase Europe's profile in cancer epigenetics research, and hopefully lead to increased public engagement in this important area of study.

Mots clés : cancer, snf complex, crispr, cas9, protac, degrader, targeted therapy, sarcoma, leukemia, rhabdoid tumour

Participants :
- Trinity College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €