Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HiPPiE_at_LHC (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

High precision is the next frontier for the Large Hadron Collider (LHC). It requires accurate and precise theoretical predictions. The goal of this project is twofold: establish a statistically solid framework for estimating the uncertainty on theoretical predictions, and producing more precise higher-order parton distribution functions (PDFs). Theoretical predictions are not exact, and carry therefore an uncertainty due to the approximate method (perturbation theory) used to compute physical observables. Assessing this uncertainty is not obvious, and standard techniques are not always reliable and lack of statistical interpretation, limiting their usability. HiPPiE@LHC will overcome these problems by proposing a Bayesian approach to assess theory uncertainties, which will make use of all the information available on the perturbative expansion and will provide a probability distribution for the unknown exact result. The approach will be similar to the Cacciari-Houdeau method, but will contain several conceptual and technical improvements, which will effectively make it more reliable. Then, new PDFs will be fitted from data using higher-order theoretical predictions, mostly based on all-order resummations, and including for the first time theory uncertainties. The computation of all the new ingredients needed to achieve this task will be part of the project. This also include the development of novel techniques (e.g., the extension of threshold resummation to fully differential level). These additions will increase the reliability and quality of the fit. The new PDFs will represent a substantial improvement over previous generations, and will be crucial for achieving higher precision in theoretical predictions. The outcome of this project will be a milestone for the High-Energy Physics community, and will open the door to high precision phenomenology in the next phase of the LHC.

Mots clés : pdfs, theory uncertainty, precision

Participants :
- National Institute for Nuclear Physics (Italie) — Coordinator, beneficiary, Recherche, subvention : 180277.2 €
Projet EpIg Men (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Highly invasive meningococcal infections with serogroup W of clonal type cc11 are rapidly increasing and have a high (16-25%) mortality rate. The aim of this project is to investigate why recent isolates are invasive and how different antibodies can protect. Special focus will be on protection of epithelial cells of the wall of the respiratory tract as prevention of infection may be key to protect the public against infection with MenW cc11. Recent clinical isolates of different clinical invasiveness will be subjected to pangenetic analyses to identify virulence factors. The ability of these isolates to infect epithelial cells will be evaluated to compare virulence factors with functional invasiveness. I then will analyse meningococcal-specific antibody levels in serum and saliva in different age groups with increased carriage and/or risk of meningococcal invasive disease. The antibodies will be evaluated for their ability to protect against infection in two different functional assays: prevention of infection of respiratory epithelial cells and the gold standard serum bactericidal assay that predicts the ability to clear invaded meningococci. Finally, epithelial responses to meningococci and modulation of these responses will be investigated. These studies will analyse cytokine and chemokine production, and the production of antibodies by B cells in epithelial-B cell co-cultures. Together, these data will a) help to identify meningococcal virulence factors and the invasiveness of MenW cc11 relative to other isolates, b) identify levels and functional ability of antibodies to protect against infection in groups at increased risk, c) help in defining a novel correlate of protection and d) reveal meningococcal-epithelial interactions. The results will provide insight for vaccine design, vaccination policy and surveillance strategies.

Mots clés : infection, meningococcal invasive disease, respiratory epithelium, antibodies

Participants :
- National Institute for Public Health and the Environment (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 187572.48 €
Projet BRCA2Interact (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Homologous recombination (HR) is an essential DNA repair mechanism and defects in different HR factors are linked with disease and cancer pre-disposition. The RAD51 recombinase plays a central role in HR, forming nucleoprotein filaments at sites of DNA damage and promoting homologous pairing and DNA strand exchange. RAD51 filament formation is mediated by the BRCA2 tumour suppressor, mutations in which lead to a high incidence of developing breast cancer. BRCA2 interacts with other HR factors, such as PALB2 and members of the RAD51 paralog family. Many of these proteins also function as tumour suppressors. The host laboratory has purified full-length BRCA2 protein and shown that it facilitates RAD51-mediated HR by acting as a molecular chaperone for RAD51 filament formation. This offers a unique position to extend our understanding of pre-recombinational protein assembly by inclusion of additional critical HR factors, and answer the important question how PALB2 and the RAD51 paralogs coordinate their activities with BRCA2 to promote the assembly of RAD51 filaments. To achieve this, I propose to: i) Characterize the biochemical and structural properties of RAD51 paralog complexes ii) Define the interplay between BRCA2, PALB2, and the RAD51 paralogs in forming pre-recombination complexes for RAD51 assembly, using biochemical approaches and electron microscopic visualisation. Given the importance of HR and its role in tumour avoidance, I anticipate our results to provide significant new insights into the molecular mechanisms underlying genome instability. Also, they may uncover novel targets for therapeutic intervention for breast cancer. Together, the proposed research will not only substantially advance knowledge of DNA repair but will also provide me with invaluable training in biochemistry, electron microscopy and project management in a world-class research environment. As such, it forms the perfect platform from which to launch my independent research career.

Mots clés : dna repair, homologous recombination, rad51 paralogs, brca2 rad51 palb2, cancer

Participants :
- Cancer Research UK (Royaume-Uni) — Partner, beneficiary, Recherche, subvention : 0.0 €
- The Francis Crick Institute (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 183454.8 €
Projet BeeSymOverSpace (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Honey bees provide both economic and societal benefits, from the honey and other commodities that they produce to the pollination services they provide. The loss of honey bee colonies and the current threats to their health are of considerable concern to bee-keepers and biologists alike. This project seeks to examine how a particular aspect of honey bee biology – the symbiotic microbiome – impacts upon honey bee health. Studies in other systems reveal heritable microbes as important modulators of disease susceptibility. This project will utilize the extensive network of bee samples across the US and UK to establish geographical patterns of heritable microbe presence in bees, and links to apiculture practice. It will then use state of the art transcriptomic and genomic approaches to establish the links between Arsenophonus, a heritable symbiont known in bees, and bee health. It will then, combine with professional agencies responsible for bee health to use these results to modify apiculture practice to establish better bee husbandry. Aside the research science completed, the project will train an EU scientist in state of the art genomic technologies and translation from discovery to applied science. It will further transfer the training gained to EU hosts, both in discovery science and application.


Participants :
- Government of the United States of America (Etats-Unis) — Partner, organization partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- University of Liverpool (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 241169.4 €
Projet TRANSACT (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Hosted at the School of Advanced Study (SAS), University of London’s prestigious research-intensive institution that brings together nine research institutes, the Fellowship will address and exploit the synergies between book history and translation history by combining the researcher’s perspective in the area of translation studies with the expertise and resources available at SAS in the field of book history. Based at the Institute of English Studies, which specializes in the history of the book, manuscript and print studies, the researcher will be able to draw on the expertise of her supervisor, Dr Andrew Nash, Reader in Book History, Deputy Director of IES, and Director of the London Rare Books School. The project will generate new knowledge about the production of English-language translations in the nineteenth century by investigating the relations between translators and their publishers and the “proto-professionalisation” of translators in Ireland and Britain, in a century marked by large-scale changes in print culture and by the increasing professionalisation of authors. The research will draw on a number of key publishers’ archival records, principally at the British Library and University of Reading. Addressing a lacuna in the history of the book, the project will provide much-needed insights into the working conditions and social circumstances of translators, both male and female, paying special attention to copyright, censorship and translators’ remuneration. Supported by an international and multidisciplinary team of academic specialists, including the Institute of Modern Languages Research, the Fellow will expand her research and professional network through dissemination activities and engagement with academic, professional and wider publics. Formal training in book history, quantitative methods, digital media, project management and curatorial work will enhance her academic and professional skills to significantly improve her career perspective.

Mots clés : book history, translation history, translators, women translators, publishers, nineteenth century, britain, ireland, authorship, copyright, censorship

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet ShaRe (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Household sizes in countries of the European Union have been declining steadily, and this trend is set to continue in the future. This is likely to ‘slow down’ reductions of per capita carbon emissions because it reduces economies of scale within households. It is important to understand these ‘reduction offsets’ in order to design effective carbon reduction policies. This project will examine the role of declining household sizes for trends in per capita carbon emissions and other environmental impacts, using longitudinal and cross-sectional household expenditure datasets for EU countries, and input-output data on emissions and other environmental impacts. Qualitative expert interviews will be carried out to formulate policy recommendations, taking underlying sociological and demographic trends into account. This project therefore seeks to make an original empirical and theoretical contribution to understanding the ways in which consumption-based emissions and environmental impacts are embedded within broader socio-cultural trends. Its policy recommendations will help to design more effective carbon reduction policies. This fellowship will facilitate a unique two-way transfer of knowledge between the host, Dr Buchs, at the University of Leeds Sustainability Research Institute, and the ER, Dr Ivanova, from the Norwegian University of Technology and Science. Dr Ivanova, a trained economist, will contribute her skills in input-output carbon footprinting modelling and econometric analysis. She will gain new knowledge and skills in the sociological and mixed methods analysis of underlying trends of household emissions and environmental impacts, as advised by Dr Buchs who is an environmental social scientist. The fellowship will equip Dr Ivanova with new knowledge, research and project management skills, enabling her to establish herself as an internationally recognised academic in this field and a connector between research, policy and civil society.

Mots clés : social embeddedness of carbon emission trajectories, sustainable consumption, changes in household size and formation, sharing economy, mixed methods research, mitigation potential

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet RSCmemory (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

How are memories formed and how do we remember them? Despite decades of memory research, these are still unanswered questions. There is consensus that the hippocampus is a key circuit for forming new memories. According to the classical model, memories that initially depend on the hippocampus, mature over time, and become increasingly dependent on distributed networks in the neocortex. While there has been great progress in understanding the molecular and genetic substrates of memory, how memories are represented by neuronal ensembles is still poorly understood. This is in part due to the lack of tools to monitor neural populations densely and repeatedly during memory formation and memory recall. The advent of two-photon microscopy and activity indicators that allow to measure the activity of nearly all neurons in a circuit, has created new opportunities to address these questions. To study how the neocortex supports memories, I will study a circuit called the retrosplenial cortex (RSC). This structure receives dense and direct input from the hippocampus and is therefore a key network to study memory. There is also substantial support for a role of RSC in memory recall, but the network mechanisms remain unknown. To study this, I will establish a novel head-fixed contextual fear conditioning task for mice that enables monitoring the activity of thousands of neurons in the RSC while conditioning under the microscope. The high spatial resolution of this method also enables measuring the activity changes of hippocampal axons projecting to RSC, thus allowing me to also measure the synaptic input to RSC. Finally, I will establish a novel technique to monitor hippocampal oscillations related to memory consolidation (so-called sharp wave ripples) and neural activity changes in RSC simultaneously. The results will address how memories are formed and recalled, and will provide important insights in what goes wrong during age- and disease related impairments of memory.

Mots clés : retrosplenial cortex, calcium imaging, learning and memory, neural coding, animal behavior

Participants :
- University of Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 208400.4 €
Projet PREBIST (Horizon 2020, appel à projets 2016)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

The PREBIST proposal is presented by the Barcelona Institute of Science and Technology (BIST) as beneficiary. PREBIST is an ambitious programme of 28 four-year fellowships for multidisciplinary pre-doctoral research at BIST´s constituent research centres and associated partner institutions (hospitals, private companies, technology centres, and other academic institutions), who will provide secondments, training, networking activities and other actions to complement the research activities and professional development of the fellows. The PREBIST proposal is a major initiative by which BIST aims to leverage the combined capacities of the constituent centres in a manner which none of them could do on their own and help achieve the strategic objectives of BIST. Key objectives of PREBIST are to: • Boost the capacity for international talent attraction with increased visibility, strengthened recruitment processes, improved offerings of research areas with interdisciplinary and intersectorial aspects, and improved landing-pad processes to facilitate mobility; • Improve BIST centre capacities in the management of researcher career development, scientific and technical training, and new offerings in complimentary skills training and outreach activities; • Further drive interdisciplinary and intersectorial collaboration between BIST centres and other partner entities through joint research activities, secondments and technical trainings, improved access and utilisation of infrastructures, networking and development of personal contacts, joint seminars and workshops.

Mots clés : doctoral training, biomedicine, nanotechnology, nanoscience, physics, astrophysics, chemistry

Participants :
- Institute for Research in Biomedicine (Espagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Barcelona Institute for Science and Technology (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 2929920.0 €
- Institut Català de Nanociència i Nanotecnologia (Espagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Institute of Photonic Sciences (Espagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Institut Català d'Investigació Química (Espagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Institute for High Energy Physics (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet ICECAP (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The Palaeogene period in the early Cenozoic (66 – 23 million year ago) saw the transition of the Earth’s climate state from Greenhouse (with no polar ice-caps, as characterised the entire Mesozoic) to Icehouse (as we see today with Polar ice caps). Understanding the dynamics in climate during such an unstable period of Earth’s climatic history is crucial for accurate forecasting of future climate change under anthropogenically-elevated atmospheric CO2. Whilst many studies have looked at particular episodes during this period (focusing on hyperthermals or the descent to icehouse in the Oligocene), there is a lack of studies which look holistically at the entire period. Furthermore, sedimentological evidence that suggests transient cool periods (local or global in scale) may have punctuated the long-term warmth of the early part of the Palaeogene have been largely overlooked as this appears to disagree with published geochemical proxy studies. This project proposes to Investigate Climatic Events, relating Cooling and Ash in the Palaeogene period (ICECAP), by generating a high resolution, multi-proxy temperature reconstruction for the exceptionally well-preserved, continuous Palaeogene succession from northern Denmark, which contain numerous thick ash horizons and enigmatic deposits associated with cold water (“glendonites”). Geochemical analysis and temperature reconstructions for other Palaeogene sites containing cold-water indicators will be undertaken in order to understand the global palaeoclimatic significance of the Danish glendonites.

Mots clés : palaeoenvironment, palaeogene climate, glendonite, volcanism climate feedbacks, organic biomarkers

Participants :
- University of Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €
Projet CHINEQUALJUSTICE (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

The People's Republic of China (PRC) gradually transitions from an export-led and investment-driven economy towards a service-led and consumption-driven economy. These upcoming reforms will affect firms that rely on Chinese goods and services, but also create new opportunities to sell goods and services to the emerging Chinese consumer market. Given the use of experimental and preferential policy treatments by the PRC over the last four decades to promote economic development, different sectors of the Chinese population and economy will have different capabilities and (dis)-advantages in the forthcoming transitions. This project will identify which population groups are heading towards prosperity and which are at greatest risk of remaining in poverty and development traps. While previous research have identified links between preferential policies and inequality, this research extends the existing studies by applying the Capabilities Approach, examining rights and social justice, which will help create a more prosperous consumer market. The varying levels of inequality, human capital, rights and social justice for the Chinese consumer market will be analyzed through club convergence and partial (meta) rankings methodologies from 1985 onwards. A development-capabilities index for different sectors of the Chinese population and economy will be developed to indicate policy makers, domestic and foreign firms, the public, and academics what the current state and potentials for the next market reforms will be. The results will be enable European, and international, firms to better target Chinese consumers and industries, and help academics develop a theoretical framework based on the Chinese preferential and experimental development experience.

Mots clés : preferential policies, human capital, inequality, capabilities approach, club convergence, partial rankings

Participants :
- Ramon Llull University (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €