Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet AISSAM (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

In today's software development problematic become new security threats that always appearing. To combat this, we can integrate penetration testing right into the development framework. With penetration testing, we can make the program mimic an attacker and simulate several different ways an attacker would try to breach the system. This gives us some immediate and valuable feedback on the system's potential weaknesses. Even when we use additional tools to do the actual pen testing, we can still derive value from doing them in the development framework. These "tests" are also valuable based in real time. The project aims to ensure more effectively uncover software vulnerabilities by combining static and symbolic analysis with artificial intelligence (AI) advances. The project objectives: 1. to analyse existing practices on minimizing positives and enhance method efficiency by harnessing AI capabilities, for results to decrease Cybersecurity problems. 2. to develop an AI-based model that improves bug detection accuracy by efficiently integrating symbolic execution with static analysis. 3. to develop AI based prototype on static and symbolic analysis improving penetration testing accuracy. AI-powered prototype will enhance current techniques by improving the resource-intensive symbolic execution process and minimizing false positives, which are frequently linked to static analysis. While current AI tools typically handle either symbolic analysis or static analysis, the AI model we will develop will cover both of them. AISSAM promises more comprehensive problem finding tool than either kind of analysis can deliver on its own. Technological impact will be made on up to 20 SME’s and will significantly increase efficiency of bug detection accuracy by efficiently integrating symbolic execution. SME’s will get also an economic impact by saving funding for cybersecurity challenges solving.

Mots clés : software vulnerabilities, static and symbolic analysis, artificial intelligence

Participants :
- Université de technologie de Kaunas (Lituanie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181136.16 €
Projet EMPHATIC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The intestine hosts a vast neuronal system, a large population of immune cells, diverse microbiota, and a complex blood and lymphatic network. The intestinal lymphatic network comprises vessels and lymphoid organs, called Peyer’s patches (PPs), that together play important roles in dietary fat absorption, mucosal immune responses and trafficking of immune cells to the rest of the body. This intestinal immune cell trafficking is key in gut-to-organ communication, and its disruption leads to immune-mediated inflammatory diseases such as inflammatory bowel disease (IBD). PP lymphatics are major routes for B- and T-cell egress from the intestine. Yet, little is known about the specific signals that modulate lymphatic control of immune cell trafficking.  This project aims to explore the novel hypothesis that a synergistic interaction between neuronal signals and PP lymphatics modulates immunity and inflammation. Building on insights from single-cell RNA sequencing of PPs, I will investigate the role of the adrenergic receptor ADRA1B in lymphatic endothelial cells. This research will focus on characterizing the molecular changes in PP lymphatic cells and elucidating patterns of immune cell egress from the gut. Also, I will examine how adrenergic signalling influences PP lymphatic function and immune cell trafficking under inflammation, mimicking IBD condition. Lastly, I will extend these findings from mouse models to humans by defining the architecture and molecular signatures of human PP endothelial cells.  This multidisciplinary project will integrate high-resolution imaging, intravital microscopy, and deep molecular profiling of both mouse and human endothelial cells to uncover this previously unexplored neuronal-lymphatic-immune axis. Given the physiological relevance of PP lymphatics as major intestinal immune gatekeepers, this work will provide novel insights into gut homeostasis and open new therapeutic avenues for treating immune-mediated inflammatory diseases.

Mots clés : intestine neuronal innervation lymphatic endothelial cells peyer s patches immune cell trafficking

Participants :
- Université catholique portugaise (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 207183.12 €
Projet DeRoCo (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Privacy infringment is one of the most prevalent forms of cybercrime, accounting for about 72% of all cybercrimes alone. Such is also the case with speaker biometrics, which, if compromised over a call, can be manipulated to generate fake speech to impersonate a person. Such identity theft over voice calls can cause financial losses, cyber-bullying and fake hate speech generation. On the other hand, in parts of the world where the communication infrastructure is not robust, a person is more agitated over not being able to get his message across over a call due to channel breakage. In such cases, privacy concerns take a back seat; but that does not imply the absence of the threat. To that end, I propose a joint solution to these issues, that can be integrated with the existing communication infrastructure. The solution consists of two segments: far-end and near-end. The far-end segment shall handle the speaker de-identification task. Existing methods of speaker anonymization are limited in terms of achievable anonymity. Improvements can be made through cycle-consistent GAN to generate better synthetic speaker representation vectors. I plan on surpassing the existing benchmark in terms of lower automatic speaker verification (ASV) scores and good automatic speech recogntion (ASR) scores. Additionally, the entire segment would be brought online for integration with real-time communication systems. The near-end segment shall be handling the speech inpainting task. While existing techniques are able to fill the blanks in acoustic signals pertaining to music and background sounds quite well, they are ill-equipped for speech. The existing speech inpainting techniques chiefly rely on spectrogram-based approaches which result in unnatural reconstructions. I plan to study novel approaches of speech inpainting, including attention based formant imputation techniques and surpass the current benchmarks for successfully filling speech gaps in the range of 1600ms.

Mots clés : speaker de identification, speech inpainting

Participants :
- Aschaffenburg University of Applied Sciences (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Athena Research and Innovation Center In Information Communication & Knowledge Technologies (Grèce) — Coordinator, beneficiary, Recherche, subvention : 181423.68 €
Projet ProBACT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The proposed ProBACT (Promoting Prosocial Bystander Actions) project focuses on examining non-refugee youth’s bystander responses to intergroup bullying of refugee youth in Turkey. Bridging developmental and intergroup processes, the ProBACT project aims to establish their interplay to promote prosocial bystander responses across two studies. Study 1 will examine social-cognitive (justice sensitivity, theory of mind, self-efficacy, and critical consciousness) and intergroup related factors (intergroup contact, perceived peer and parental norms towards outgroup members, media perceptions about refugees, discriminatory attitudes) in Turkish youth’s bystander responses to intergroup bullying of their Syrian peers through hypothetical scenarios. By extending Study 1, Study 2 will test the effectiveness of a novel intervention program that covers components of intergroup contact, outgroup mentalizing, and role models in promoting youth's prosocial bystander responses to intergroup bullying of refugee peers. The proposed ProBACT project will help to identify the factors that pose a threat to refugee youth's inclusion and wellbeing and to harmonious intergroup relations by combining multiple methodologies. This is an especially timely and important issue based on the evidence demonstrating increasing negative interactions between Turkish and Syrian youth in school contexts. The proposal will advance our understanding of social-cognitive intergroup processes in youth's prosocial bystander responses to intergroup bullying of their refugee peer. Overall, the implications of the ProBACT project will provide a novel understanding of promoting safety, inclusion, and justice in the education system and research that aligns closely with the values of the European Commission.

Mots clés : intergroup bullying, bystander responses, prejudice and discrimination, intergroup contact, victimization of syrian refugees in turkey, theory of mind, self efficacy, justice sensitivity, intervention

Participants :
- Université Bilkent (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 132638.4 €
Projet SkinModelOma (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

One of the biggest limitations in developing new treatments for cutaneous melanoma relies on overcoming the inefficient screening, often to animal models, which greatly differ from humans. Also, the 3Rs principle limits the number of therapeutics that actually reach the in vivo evaluation of product/drug development or discovery. Thus, there is a high demand for novel pre-clinical platforms, as alternative models to the use of animals, that can screening new treatments. I propose the establishment of a multicompartmental melanoma graft model based on an ex vivo skin tissue grafted with a multicellular spheroid composed by melanoma cells, keratinocytes and monocytes. The ex vivo melanoma graft model, called SkinModelOma, will be a major breakthrough in the study of melanoma tumor growth and on the effectiveness of new therapies in different types of skin and considering gender and age. To the best of my knowledge, this will be the first ex vivo melanoma graft model, and the first model for skin cancer considering age, gender and skin type as important parameters in novel therapies screening for skin cancer. This proposal includes 3 scientific work packages related to 3 objectives and includes transversal work packages related to my training and improviment as a researcher. The objectives are based in the development and standardization of multicellular spheroid, their graft in the human skin and the validation of this model as a screening platform. I believed that the SkinModelOma proposed here will contribute to significant scientific advances in cutaneous melanoma patients’ management and also to great international recognition that will enable other researchers to benefit from a novel pre-clinical tool.

Mots clés : tissue culture, 3d spheroids, screening platforms, skin cancer, nanomedicines

Participants :
- Institut de Recherche et d’Innovation en Santé de l’Université de Porto (Portugal) — Coordinator, beneficiary, Recherche, subvention : 172618.56 €
Projet Target-MelaneX (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Melanoma, the deadliest form of skin cancer, is strongly influenced by environmental factors such as UV radiation from ozone depletion. In 2022, there were 331,722 new melanoma cases globally, and by 2040, cases are expected to rise by 50%. A major challenge in treating melanoma is its ability to metastasize, especially when therapeutic targets are unclear or when tumors develop resistance to existing treatments. Recent research findings have identified the nerve growth factor receptor p75NTR as a key player in melanoma progression, invasion, and metastasis, especially in highly metastatic melanoma cells. This project aims to target p75NTR in melanoma cells and extracellular vesicles (EVs) to inhibit melanoma progression. While p75NTR role has been identified in melanoma cells, its role in tumor-derived EVs—responsible for cell communication and metastasis—remains under-explored. This project aims to block p75NTR in both melanoma cells and EVs, where co-receptors and co-effectors availability and cellular interactions differ from that within cells, potentially offering a new therapeutic approach. Leveraging phage display technique, the project will identify peptide ligands specific to p75NTR on melanoma cells and EVs. Outcomes from this Fellowship will benefit several scientific communities, including those working in biomaterials and peptide sciences and, cancer, while providing advanced training and career development opportunities for a young researcher at the intersection of targeted cancer therapies, advanced biomaterials design and peptide technology, preparing her for a leadership role in translational cancer research. By addressing both melanoma cells and EVs, this project introduces a dual-targeted strategy with the potential to transform the understanding of melanoma biology and open new avenues for more effective therapies.

Mots clés : hyaluronan, peptides, phage display, targeting, melanoma, extracellular vesicles evs , nerve growth factor receptor p75ntr , cell invasion and migration, peptide receptor interactions

Participants :
- Institut de Recherche et d’Innovation en Santé de l’Université de Porto (Portugal) — Coordinator, beneficiary, Recherche, subvention : 207183.12 €
Projet NeuroAdapt (Horizon Europe, appel à projets 2023)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

The overall objective of NeuroAdapt, led by the Royal College of Surgeons in Ireland, is to train and there by equip the next generation of researcher leaders with the scientific and transferable skills to catalyse their careers, both in academia or beyond, and develop much needed innovative, safer, and more effective therapeutic approaches to brain diseases, one of the most pressing challenges in European healthcare, tailored specifically towards individual patient needs. Fellows will work within FutureNeuro, a world-leading Science Foundation Ireland (SFI) Centre, bringing together Ireland’s leading researchers in the field of neurodiagnostics, neurotherapeutics and digital health. In an internationally unique manner, FutureNeuro links innovative neurodiagnostics and neurotherapeutics development with a national digital health infrastructure and a nationwide clinical network. NeuroAdapt will build on the excellent research environment and expertise of the FutureNeuro centre, providing a fertile training ground for the Fellows. Researcher training will include a unique combination of “hands-on” research training, placements in industry and hospital settings and courses and workshops on scientific, industry-related and transferable skills facilitated by the academic and non-academic composition. Importantly, with its strong focus on industry-related diagnostics and drug discovery programs, NeuroAdapt will facilitate the implementation of novel discoveries into clinical use. Adhering to the COFUND principle of ‘individual-driven mobility’, NeuroAdapt applicants will freely choose, according to their individual needs, from a wide range of research fields, host organisations, supervisors and secondment organisations. NeuroAdapt Fellows will work in highly interdisciplinary projects, sharing expertise and adding value across the neuroscience research landscape. Proposals can be submitted around the three themes of diagnostics, therapeutics and digital health.

Mots clés : neuroscience, brain diseases, diagnosis, treatment, digital health, patient focused

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1050720.0 €
Projet ILIAS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

ILIAS investigates how socio-cultural, affective and scientific perceptions shape the implementation of EU laws for the prevention and management of invasive alien animal and plant species (IAS) in EU member countries. The European Parliament legislates policy responses to a list of 66 IAS of EU concern, but conceptual, socio-cultural and practical barriers prevent collaborative implementation. Key terms such as ‘biodiversity’ or ‘nature’ lack a shared definition; methods for the management and eradication of IAS are controversial; academic experts engage in fractious disagreements. These issues, which complicate unified strategies to prevent and manage IAS across EU member countries, point to implicit and unacknowledged socio-cultural factors that shape human relationships with the environment including religious beliefs, ideas about local identity and heritage and anxieties about environmental change. ILIAS studies these socio-cultural attitudes and framings around species dispersal, their influence on the way scientific evidence and best-practice for IAS management among stakeholder groups are interpreted, and how this affects the implementation of EU laws using interdisciplinary methods and theoretical frameworks. ILIAS is based on the following research questions: How do personal attitudes, beliefs and value judgements among stakeholders shape the implementation in different member countries? How do socio-cultural framings influence the interpretation of scientific evidence? Do the different conceptualisations present barriers in collaborative action and compliance with EU laws and if so, how can a more unified approach be facilitated? The resulting insights will contribute to a better understanding of the barriers to implementing coordinated strategies across EU member countries. They will point to differences in how stakeholders define key concepts, and to the affective, cultural and gendered frameworks that influence how scientific evidence is interpreted.

Mots clés : invasive alien species bioinvasions eu policy globalization climate change natura 2000 invasion denialism ecological restoration conservation ecology eu governance rights of nature

Participants :
- Université de Coimbra (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
Projet Marine Biorefinery (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

While global fish depletion, environmental pollution, and food security are challenging modern society, over 138 million tons of fish processing by-products (FPBs), including fish processing wastes, by-catches, and marine invasive species, yearly produced in Europe are underutilised with about 55.2 million tons of these are annually landfilled as Category-3 waste. This not only costs €179 per ton for waste treatment and contribute to environmental pollution but also wastes marine bioresources because FPBs are rich resources of proteins, collagen, chitin, lipids, omega-3 fatty acids, calcium, and minerals with commercial applications in foods and nutraceuticals. Efficiently utilising these FPBs for value-added products would not only mitigate the above pressing challenges but also minimise processing costs and produce more food/bioproducts for the increasing population towards sustainable production for a circular blue bioeconomy. However, the conventional recovery of nutrients from FPBs is still challenging due to low extraction efficiency, the complexity of the multi-step process, and high production costs. This project aims to develop an advanced process for multi-product biorefinery of FPBs to efficiently produce nutritional proteins, functional collagen, omega-3-rich oils, and calcium-rich minerals for foods and nutraceuticals by integrating different technologies with synergistic effects. While emerging technologies such as microwave, ultrasound, and supercritical CO2 can physically and biologically intensify the process for enhancing efficiency, shortening processing time, saving energy, and minimising solvents used, the use of a two-phasis system (TPS) composed of switchable hydrophilic/hydrophobic DESs/NADESs enables simplifying the biorefinery process and facilitate separation and product recovery for dramatically saving production costs. Such significant advances combined with optimisation make the proposed process efficient for the biorefinery.

Mots clés : marine biorefinery, sustainable production, marine nutrients, food recovery, 

Participants :
- Technological University Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 268568.64 €
Projet WeWriTe (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The quality of a written text is often described in figurative terms, such as clearness and smoothness. The explicit description of what makes a text clear and smoothly flowing is a challenging task, probably because the readers’ perception of a text is influenced by multiple variables, related to the way information is structured, and how the writer employs the lexical and morphosyntactic resources of a language. The difficulty in translating the readers’ perceptions of a text in measurable descriptors leads to challenges in literacy education. For instance, how can educators explain what makes a text clear and smoothly flowing? What are the crucial aspect to focus on when giving feedback or conducting formative assessment? Answering these questions is of fundamental importance, given that writing literacy may have a considerable impact on employability, social participation and lifelong learning. This project aims to explore the relationship between the holistic evaluation of texts, carried out by expert evaluators, and their linguistic characteristics, to understand to what extent it is possible to identify objective and measurable properties that distinguish texts perceived as well written, compared to those with less positive ratings. For this purpose, we will establish a corpus of argumentative and narrative texts, written by university students, who are L1, L2 (or L3) speakers of Italian, a language that has received little attention so far in international research on writing. The methods of analysis involve the use of linguistic indices identified by previous research, which focus on the lexical and morphosyntactic complexity of the texts, and their integration with new indices, based on the Basel model of text analysis. This model contributes to a deeper understanding of the architecture of a text, by analysing how information is structured and hierarchized, and how textual units are connected on different semantic-pragmatic levels.

Mots clés : analysis of texts in italian, basel model of text analysis, the architecture of a written text, holistic and analytic assessment of written texts

Participants :
- Université de Bâle (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Modène et de Reggio Emilie (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 368071.68 €
- Liceo classico megara sez scientifica annessa (Italie) — Partner, associated partner, Autres, subvention : 0.0 €