Projet switchBoard (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

All visual information is broadcasted by an intra-retinal pathway formed by a group of neurons called bipolar cells. They collect photoreceptor signals in the outer retina and relay the signals to the inner retinal neurons. This transfer of visual information is far from passive: Each of the at least 10 bipolar cell types transforms the photoreceptor signals in a unique and highly specific way. As a result, the bipolar cell output signals form the first “elementary operations” from which the neural circuits of the inner retina compose a feature-oriented description of the visual world. Reflecting the partitioning of visual information into parallel channels, the retinal layer in which bipolar cell axon terminals meet their synaptic partners, is highly organized: This so-called “inner plexiform layer” effectively serves as the retina’s “switch board”: The input is provided by the different bipolar cell “channels”, while the output is carried by an even larger number of channels, represented by ganglion cells that form the optic nerve. Each of the ~20 ganglion cell types composes its feature-extracting circuits from a specific set of bipolar cell input it receives. Owing to its regular structure and ease of experimental access, the retina is amongst the best understood self-standing neuronal networks in neuroscience. Indeed, recent advances hold the exciting promise that an in-depth understanding of the bipolar cells – an entire class of neurons – and their role in the first critical steps of visual processing is within reach. Our proposal aims to train young researchers in world-leading research labs towards completing this goal. We will accomplish this by exposing the students to a host of cutting-edge techniques and a broad spectrum of research approaches within the training network – from imaging at synaptic resolution, transgenetics and retina degeneration models to the application of retinal circuit principles for signal processing in artificial vision chips.

Mots clés : early visual system, retina, neuronal signal processing, neuronal projections, computational retina models, visual feature extraction, neurotechnology

Participants :
- TU Wien (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255934.08 €
- Universität Innsbruck (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 511868.16 €
- University of Tübingen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 498432.9 €
- Harvard Bioscience (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- Grasshopper films gmbh (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Inilabs ag (Suisse) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 265226.76 €
- Royal Netherlands Academy of Arts and Sciences (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 510748.56 €
- Carl von Ossietzky University of Oldenburg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 249216.48 €
- Natural and Medical Sciences Institute (Allemagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Bergen Science Center (Norvège) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- European vision institute (Belgique) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- National Research Council (Italie) — Partner, beneficiary, Recherche, subvention : 258061.32 €
- University of Bergen (Norvège) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 286275.24 €
- University of Sussex (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 522504.42 €
- Ekb technologies ltd (Israël) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 253069.95 €