Projet Bio-TUNE (Horizon 2020, appel à projets 2019)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : SIGNED

Bio-TUNE aims to develop innovative multifunctional materials to produce a new generation of medical implants with cell instructive and antibacterial potential. In biomaterials science, it is well accepted that implant biointegration with surrounding tissues is a major goal. However, implant surfaces that facilitate cell adhesion, may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can be catastrophic and significantly reduce patient quality of life, representing an emerging concern in healthcare. On the other hand, research efforts devoted to inhibit bacterial colonization are frequently related to cytotoxic agents or treatments that do not positively affect host tissues. Hence, ideally, to enhance the long-term success of medical implants, biomaterial surfaces should reduce bacterial colonization levels without compromising the physiological functions of eukaryotic cells. Yet, the majority of current approaches tend to only focus on either improving cell adhesion or preventing bacterial infection but rarely explore a combined effect. In Bio-TUNE we focus on multifunctional coatings to simultaneously address and mitigate both these problems. Thus, Bio-TUNE introduces a new mindset and different paradigms in the development of biomaterials to respond to unmet clinical needs. Bio-TUNE ambitions to 1) Study and understand the interaction of eukaryotic cells with bacteria at the biophysical and biomolecular level; 2) To develop cell instructive and antibacterial surfaces via biochemical and topographical approaches; 3) Transfer this technology to medical implants. We seek to decipher the mechanistic of eukaryotic and bacterial cell competition, generate new selective and multi-potential coatings and topographically-active patterns, and their technological transfer leading to a generation of advanced biomimetic materials for tissue regeneration and personalized medicine.

Mots clés : biosensing, cell instructive materials, antibacterial surfaces, micro  and nanostructured materials, surface functionalization, multifunctional coatings, immune response, medical implants

Participants :
- Universitat Politècnica de Catalunya (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 216200.0 €
- Università di Camerino (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 211600.0 €
- University of Glasgow (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110400.0 €
- Universitas Gadjah Mada (Indonésie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Max Planck Society (Allemagne) — Partner, beneficiary, Recherche, subvention : 87400.0 €
- National University of General San Martín (Argentine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 78200.0 €
- Peruvian University of Applied Sciences (Pérou) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Universiti Sains Malaysia (Malaisie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Bristol (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110400.0 €