Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ONFIRE (Horizon 2020, appel à projets 2017)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

Future (5G) services will impose stringent requirements in the design and operation of transport networks: increased capacity, low latency, high availability and dynamicity, reduced service provisioning with lower OpEx, while considering end-to-end service objectives (QoS and QoT). To cope with traffic growth in a cost-effective way, an appealing strategy focuses on deploying elastic and programmable commodity optical hardware via disaggregation (white boxes) combined with transmission technologies. To address both end-to-end service objectives and traffic dynamicity, an interesting approach leverages the benefits provided by SDN/NFV control and the automated decisions and re-configuration opportunities enabled by cognitive algorithms. For this, SDN/NFV provides unified control on top of systems’/devices’ programmability, regardless of the data infrastructure (packet, optical, IT), while exploiting the large real-time monitored information dynamically to adopt actions leading to attain service end-to-end objectives and more optimal network operation and resource utilization. Those hardware and software solutions constitute ONFIRE R&D goals which basically target the design, deployment and experimental evaluation of disaggregated optical transport hardware automatically articulated by novel cognitive algorithms supported by a SDN/NFV architecture. To do so, ONFIRE proposes a three-year research programme centred on two European industrial PhDs. PhD candidates will benefit from an intensive training process combining the strengths of both: i) CTTC as research institution to acquire research tools and methodology, with UPC as associated partner offering its PhD programme; ii) ALUD as a vendor delivering a highly valuable view of research activities and its impact on industrial ecosystem. Targeted PhD training programme is devised to maximize the synergy between the collaborators and promote career opportunities of ONFIRE researchers in the European ICT Research Area.

Mots clés : cognitive optical networks, sdn and nfv control, orchestration, disaggregated optical networks, white boxes, real time monitoring, elastic and programmable optical hardware, cost efficient networks

Participants :
- CERCA Institution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 495745.92 €
- Universitat Politècnica de Catalunya (Espagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Nokia (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
Projet SCOOBA (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Future climate change scenarios predict an increase of 1.8-4ºC in sea surface temperature and a projected two-fold increase in atmospheric CO2 concentration by 2100, causing ocean acidification. These conditions may particularly affect coral reef ecosystems where coral-Symbiodinium symbiosis will be destabilized and the solubility of CaCO3 will increase, modifying the marine habitat and altering the biocoenosis. Apart from corals, sponges are also highly abundant in reef ecosystems worldwide and possess a wide range of functional roles essential for the proper functioning of the system. Predictions of global warming can also affect sponge populations. Boring sponges form close associations with dinoflagellates and can host quite diverse bacterial symbionts. These sponges provide the opportunity to define the interactions between symbionts, and between symbiont communities and their host under a climate change context. We will evaluate different types of microbial diversity (eukaryotic and prokaryotic) in a single host species. We will then manipulate bacterial and dinoflagellate symbioses to tease apart symbiont contributions to the host phenotype and to test for the sensitivity to thermal and pH stress in the context of sponge behavior (i.e., feeding, growth, and boring activity). Finally, we will link sponge microbiomes from different biogeographic regions at an intra- and interspecific level. To achieve our goals, we will use a novel approach in the field of sponge symbiosis applying the newest technologies of sequencing and cell culturing.

Mots clés : sponge symbiosis, symbiont interactions, bacterial community, cliona, symbiodinium, global warming

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 239191.2 €
- University of Richmond (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet S-OMMs (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Futuristic smart optical applications belong to novel artificial materials comprising nanoscale building blocks, exhibiting extra-ordinary optical responses. Recent progress in nanotechnology has enabled developing such optical metamaterials (OMMs) economically via controlled self-assembly of nanoparticles (NPs). Strikingly, a dense nanometre-thick layer of metallic NPs strongly reflects incident light like a ‘mirror’, whereas a sparse layer enacts a near-transparent ‘window’. Thus OMMs could form a switchable mirror–window to minimize our energy needs by harvesting light. Besides tuneable-optics, dense OMMs could revolutionise sensing of trace-analytes for detecting threats to our health, safety, and security. I aim to develop new means of dynamic control over resulting NP-layer architecture to make OMMs ‘smart’, for novel applications like fast-programmable mirrors, -tuneable optical-filters and -cavities. But achieving quick alteration of NP architectures for fast-tuneable optical response is very challenging. Voltage-controlled assembly and disassembly of NPs at interfaces between liquid electrolyte and solid electrodes could be one efficient method. However, these processes are often diffusion-limited, making OMMs slow to respond. This requires the desired systems to be confined, or miniaturized, by developing new schemes and custom-made architectures to ensure assembly/disassembly occurs within sub-second timescales. To achieve this, I will engage novel electrode designs—patterned as rectangular-groove gratings, columnar structures, and flat transparent plates—where NPs can rearrange quickly on desired areas of the electrodes to either reflect or transmit light. This research unites physical-chemistry with optics and nanotechnology. I will develop optimal designs of the systems, via modelling and simulations, and navigate experiments for prototype creation in collaborating laboratories of the Imperial and overseas partners in France, Netherlands, and Germany.

Mots clés : optical reflectance and transmittance, self assembly, electro tuneability, electrodes, solid liquid interfaces, surface plasmon resonance, nanoparticles

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet ReXeG (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

G-quadruplex (G4) structures are stable four-stranded nucleic acids assemblies that can form in guanine-rich DNA. Their recent visualization in mammalian cells has established G4 structure formation throughout the genome and fueled research into understanding the biological implications of these structures in cell regulation. G4 sequence motifs are abundant and conserved in our genome. G4 structures form transiently and regulate numerous cellular processes such as DNA replication, transcription and telomere maintenance. Importantly, these structures also come at a cost as they are able to induce genomic instability in certain cellular conditions, for example in cancer cells that suffer from replication stress. Currently, the mechanisms that form and resolve G4 structures are unknown. Several helicases can unwind these stable DNA structures in vitro but it is unclear whether and how these helicases function in vivo. Understanding the biochemical mechanisms that resolve G4 structures is crucial to further understand their function and how they induce DNA mutations in the cell. In this project, I propose to decipher the molecular mechanisms of G4 structures unwinding. The groundbreaking nature of this proposal is the use of a unique method to follow G-quadruplex unfolding in time under near-physiological conditions in vitro. This method, which was recently established in the host laboratory, uses DNA replication stalling and bypass at defined G4 structures as a direct readout for G4 stability and unwinding. This gives me the opportunity to address important aspects that have not been studied under physiological conditions before: Aim 1: To determine the stability and unwinding properties of distinct G4 conformations. Aim 2: To identify molecular mechanisms and novel proteins in G4 unwinding. The results of this project will give important new insights into G4 regulation, an unexplored but important biological process.

Mots clés : g quadruplex  g4  structures, dna replication, xenopus egg extract, genome stability, dna protein interaction

Participants :
- Royal Netherlands Academy of Arts and Sciences (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 165598.8 €
Projet GAPSLE (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

GAPSLE is an interdisciplinary project studying criminal justice system (CJS) in Norway. It recognises the need to go beyond individual skill-based learning and promotes development of collaborative learning as a way to find new innovative ways of working, increase staff’s work-based well-being and reduce reoffending rates in prisons. The underlaying rationale is contributing to making the EU a more secure society. The approach is to (1) empirically explore the current state of collaborative learning activities nationally by interviewing professionals across CJS and analysing documents, (2) empirically explore tensions around collaborative learning by interviewing professionals across CJS, (3) conduct a survey and develop an assessment tool to chart CJS practitioners’ readiness for collaborative learning and (4) develop a strategy to support collaborative organizational learning activities among different occupational groups and creation of social innovations within CJS. Cultural-historical activity theory and expansive learning give the theoretical framework for the study. Their strength is to allow going beyond individuals and to take into account larger contextual and systemic activity (e.g. organizational structures, rules, community) when analysing learning and activity. Methodologically they provide with established methods to analyse need state (readiness) and tensions within an activity. The expected outcomes will be exploited by practitioners, educators and decisionmakers within CJS to support in reviewing and designing learning events and strategies, and academics in the field of workplace learning to develop methodologies. Furthermore, they are expected to raise interest among layperson who have interest towards prison work, prison services and issues contributing to a safer society.

Mots clés : collaborative learning, social innovations, organizational learning interventions, mixed methods, correctional services, prison work

Participants :
- University of Stavanger (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202158.72 €
Projet GEMILLI (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

GEMILLI – Gender, Migration and Illiteracy. Policy and Practice for Social Integration aims to analyse the intersections of gender, migration and illiteracy in contemporary European societies, and to give evidence on policy and practice developments for the social integration of migrant women with low literacy in Europe. Building on the existing literature and research evidence, GEMILLI proposes an intersectional, comprehensive and integrated approach, able to advance knowledge further and to inform social policy in the context of the European Union. Considering the present trends of international migration in Europe and the political and scientific challenges brought by the so-called migration crisis and by the increasing inflows of migrants from countries with high illiteracy, this project proposes a comparative, cross-country and multi-scope analysis of policy and practice between old and new immigration countries, taking Spain and France as case studies. GEMILLI will give evidence on a) the main country-differences regarding the social integration of migrant women with low literacy levels; b) the nature, characteristics and functioning of the local organisations working directly with migrant women with low literacy levels and in charge of training, alphabetisation, language learning, and social integration actions; c) the impacts of the intersections of gender, migration and illiteracy for the life trajectories of women. The research design contemplates both the qualitative and quantitative dimensions of the phenomenon and considers macro (institutional/policy), meso (organisation/practice) and micro (individuals/biographies) levels of analysis. It uses a mix-method methodology, combining complementary research strategies such as policy and institutional analysis, organisational case studies and life stories. The project foresees two short-visits for fieldwork in local organisations in the France and in Spain, and a Secondment in The Council of Europe.

Mots clés : women, migration, adult illiteracy, intersectionalities

Participants :
- Autonomous University of Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160932.48 €
Projet GEiMS (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

GEiMS will be the first ever project to enable the realistic and prompt application of decentralized State Estimation (SE) at Medium Voltage (MV) Distribution Systems (DS) of electricity. A wide, concise, adaptive and straight-forward SE framework for MV DS will be delivered, based on the novel, but readily available features of the GridEye Base Module (GBM) equipment, which is integrated over GridEye Network Supervision, a fully operational monitoring and control ICT platform, both developed by DEPsys (host institution of GEiMS). The Experienced Researcher (ER) will contribute greatly to GEiMS thanks to his vast experience in the recent years of his studies and work on the field of MV DS. To achieve the goals of GEiMS, first, the calculation of the phasors performed by the GBM equipment will be improved, based on proper time domain models of the DS infrastructure. Following, and since SE may be viewed as an optimization problem, the GEiMS platform will include distributed optimization techniques to realize SE for MV DS. However, due to the limited availability of metering (and, thus, processing) infrastructure at DS, a complementary decentralized SE method will also be added to the GEiMS platform. Given the special characteristics of DS, the correlation of errors across types of the measurements and pseudomeasurements required in SE methods will be explored extensively. The GEiMS framework will also account for practical critical issues that may threaten the integrity of SE and devise plans to ensure improved efficiency of the tool under all circumstances. The framework will be assessed on an actual test-bed distribution feeder. The whole GEiMS project will be developed in close collaboration with Swiss and European DSOs, thus ensuring its practical value for the R&D panel at hand, as also offer ample potential and opportunities to the ER leading this work.

Mots clés : state estimation, distribution systems, distributed optimization, phasor measurement units, measurement error correlation

Participants :
- Depsys sa (Suisse) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 175419.6 €
Projet GLIBAL (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

GLIBAL – The Global Dimension of the Libyan Crisis will provide a new reading of Libya’s ongoing war from a global perspective. Breaking with current interpretations that present the war as a result of historically self-inflicted and local problems, the project’s overall objective is to investigate how those processes that were central to the making of the US-led global order unfolded, shaped and were contested in a key country of the EU’s Southern Neighbourhood from 1969 to the present. It does so by capturing the manifold and interactive character that its people and places bear with those projects of financial and political control that consolidated at the global level from the end of WWII to the present day. By creating a better and timely understanding of the situation, the focus of the project will contribute to clarify the ways in which evolving global governance schemes—of which the EU is a major player—are connected to the formulation of policies to prevent conflict and tackle the issue of migration in the EU’s Southern Neighbourhood. More specifically, it aims to contribute to major areas of EU policy (European Neighbourhood Policy, Common Security and Defence Policy and EU Global Approach to Migration and Mobility). To accomplish this goal, GLIBAL will be undertaken in collaboration with two major academic institutions, Ca’ Foscari University of Venice (UNIVE) and Columbia University in the City of New York (CU), and under the guidance and supervision of the most apt and internationally established scholars, Profs Matteo Legrenzi and Timothy Mitchell. The expected results for the researcher’s career are: The consolidation of research outputs disseminated at the highest scientific level—and of communication activities fruitfully bridging research and positive societal impact issues—to underlie the achievement of a tenure-track academic position in his fields of specialization (Global and Middle East Studies).

Mots clés : libya, global war, global order, middle east and north africa

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269002.56 €
- Columbia University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SEAGAS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Gas hydrates are ice-like compounds that form within near-seabed sediments on continental margins, concentrating greenhouse gases (mainly methane) within what is estimated to be the largest reserve of hydrocarbons on Earth. The stability of this frozen sub-oceanic reservoir is sensitive to changes in sea-level and temperature over time, but also to the poorly understood dynamics of chimney-like structures observed to vent gas to the oceans. An understanding of gas venting from hydrates over time is of scientific and social relevance, due to potential impacts on global carbon budgets, regional geohazard assessments and future energy resources. SEAGAS is the first project to propose a comparative analysis of gas hydrate systems on continental margins that have experienced differing forms of glacial-interglacial climate forcing: an open ocean (the South Atlantic) and a semi-enclosed sea (the Mediterranean). The project will perform numerical modeling of changes in gas hydrate stability on both margins, to guide analyses of marine geophysical, geological and geochemical datasets held by the outgoing and return hosts, as well as of data to be obtained during a joint acquisition campaign to the Nile fan. SEAGAS leverages ongoing high-level research programmes by the outgoing and return hosts, which offer multi-disciplinary expertise and datasets, as well as access to ship-time. The key training objective is for the researcher to acquire new skills in marine geochemical concepts and methods with the Brazilian host, in order to broaden his existing competencies (and those of the French host) in marine geophysics and geology. SEAGAS has the strategic objective of consolidating a nascent collaboration between the outgoing and return hosts, with strong potential for further collaborations. SEAGAS will thus make an impact on European research excellence and competitiveness while resulting in a diversification of competencies in a field of strategic interest for the ERA.

Mots clés : gas hydrate, fluid venting, glacial interglacial climate change, marine geochemistry, geology, geophysics

Participants :
- Pontifical Catholic University of Rio Grande do Sul (Brésil) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 238410.0 €
Projet GlycoModels (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Gastric cancer is an important health problem, being the fifth most common cancer and the third leading cause of cancer death. Its late diagnosis accompanied with a bad prognosis keeps this malignancy among the most deadly. After generations of cancer therapy based on chemical drugs causing severe side effects and limited efficiency, cancer treatment undergoes a paradigm shift towards targeted therapy, employing both monoclonal antibodies and small molecule inhibitors of receptor tyrosine kinase activity, as the most promising tool for the years to come. However, there are numerous patients that do not respond to these novel treatments due to mutations in downstream signalling pathways or to undefined molecular mechanisms. Protein glycosylation has been shown to modulate cellular receptor functions and alter antibody binding affinities and therefore foreshadows to play a major role in cancer therapy resistance. The GlycoModels project aims to identify glycan alterations on cell receptors that lead to targeted therapy resistance of gastric tumours. Using cutting-edge gene editing techniques, gastric cancer cell lines will be glyco-engineered to express hallmark glycan epitopes and applied in 3D-culture systems as advanced models mimicking the tumour microenvironment. These 3D-GlycoModels will display differential response to treatment with the most promising targeted therapy agents for key cell receptors (HER2, VEGFR, MET and RON) involved in growth, progression, and spread of cancer. In-depth analysis of the GlycoModels, covering glycan characterisation of the cell receptors, disclosing activated signalling pathways, and transcriptomics will unveil our understanding on driving mechanisms in therapy resistance and the glycosylation patterns involved. The structural validation of these glycoforms in human samples will deliver new biomarkers to be used in personalised therapy selection and thus, improve the outcome of advanced gastric cancer patients.

Mots clés : glycosylation, genetic engineering, 3d cell model, tyrosine kinase receptor and signalling

Participants :
- University of Porto (Portugal) — Coordinator, beneficiary, Recherche, subvention : 148635.6 €