Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet WILA19-91 (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

WILA19-91 main aim is to to bridge the gap between intellectual history and labor history, and through this methodological innovation not only highlight the disparity between intellectual labor and intellectual achievements, but also challenge historiography's perception of the latter. While intellectual history predominantly focuses on artistic and intellectual achievements, it often fails to question the underlying conditions that made such achievements possible. Consequently, many marginalized groups have been excluded from the canon, as they did not have the necessary working conditions to consistently produce intellectual or artistic labor. The WILA19-91 project focuses specifically on women's intellectual labor from 1919 to 1991, utilizing Yugoslavia as a transnational laboratory space to observe the dynamics of intellectual and artistic labor across different time periods, generations, social classes, nationalities, and ethnicities. The project's outcomes will contribute to establishing new norms for reevaluating artistic and intellectual achievements, ultimately broadening and decolonizing the canon. The project examines work conditions, considering the power structures associated with intellectual authorities, social prejudices, intimate beliefs, and invisible social agreements at various times. To achieve this, it explores the intersection of intellectual, labor, and gender history. By drawing on a diverse range of sources in different languages (Slovene, Croatian, Serbian, German) and amplifying the voices of women from ethnic and sexual minorities, this project will investigate working conditions, attitudes towards work, legislative changes, family dynamics, public reception, financial compensation and care work, in order to understand the division between intellectual work (as labor) and being an intellectual (as a status).

Mots clés : intellectual work, artistic work, valuation of intellectual and artistic work, gender, yugoslavia, labor centric perspective

Participants :
- Université de Vienne (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199440.96 €
Projet 4TB (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The "Transmission and Transformation of Texts in the Tarim Basin: a corpus approach" project (4TB) is designed to contribute to the study of three prominent languages of the pre-Islamic Tarim Basin (in today’s Xinjiang Uygur Autonomous Region in the People’s Republic of China): Tocharian A, Old Uyghur, and Sanskrit. The innovation part of this contribution assumes creating a comprehensive parallel text corpus of Buddhist texts in the said languages, an open-access digital tool for linguistic and philological study. The research part assumes analyzing details and searching for patterns of transmission and transformation of those Buddhist texts, from Sanskrit to Tocharian A, from Tocharian A to Old Uyghur. This is going to be achieved by answering the following research questions: 1) What are the linguistic patterns of transmission and transformation of the discussed texts? 2) How were the discussed texts transmitted and transformed from the philological point of view? The results of my action will substantially facilitate cross-linguistic studies for scholars of three language groups. Also, they will have an interdisciplinary impact, bringing a large amount of textual information to non-linguist researchers, e.g., scholars of Buddhism and historians. Moreover, my action has a potential for further research, as it can later include other adjacent languages. The host institution will be University of Vienna. My supervisor will be Hannes Fellner, one of the key developers of the CEToM project (the Tocharian A and B text corpus) and the lead of the Tarim Brahmi project. His experience in Digital Humanities and the Tocharian studies will be extremely helpful for my research.

Mots clés : digital humanities tarim basin studies

Participants :
- Université de Vienne (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183600.96 €
Projet QUAKERTY (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This academic research, entitled 'Governing Quakerty', focuses on the intersection of 'quake' and 'property', and sheds light on property governance in a post-disaster context, particularly in and around the recently quake-affected area of Antakya, in Türkiye, where the research is focused. The central research question is: How does property governance unfold in the earthquake-affected city, and what are the governmental, communal, and individual strategies implemented to deal with land and property loss, appropriation, and the ensuing processes of re-entitlement during the reconstruction period? The research examines the dynamics of disaster property in a post-quake context, encompassing both the collapse (the process of alienation) and reconstruction (the process of re-entitlement) phases, by investigating (a) the disposal, recycling and governance of earthquake-damaged property and personal belongings within collapsed or damaged buildings; (b) the process of post-disaster property claims and strategies for re-entitlement and ownership during relief and reconstruction efforts. By examining the circulation of property along the processes of loss, recycling, reconstruction and re-entitlement in the context of a destroyed urban landscape, in conjunction with legal and institutional contexts and policies, as well as the strategies and experiences of affected individuals, this scholarly investigation will make a critical contribution to the development of an effective approach to property governance in quake-affected areas, thereby assisting resilient and inclusive post-disaster property recovery efforts.

Mots clés : property, earthquake, destruction, rubble, forced displacement, land grabbing, recycling, reconstruction

Participants :
- Université de Vienne (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183600.96 €
Projet RANGE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Plant range size (geographic area occupied by a species), a key predictor of species’ extinction risk, is shaped by an interplay of evolutionary and ecological processes. Yet understanding how species’ biological traits interact with environmental factors to determine range size remains challenging. I hypothesize that plant trait flexibility (ability of traits to evolve to different trait states) and genome size (total DNA in cell’s nucleus) are two key biological factors that influence range size. Genome size imposes biophysical constraints on cell size and rate-related cellular traits (like cell cycle duration) impacting functional traits, e.g., photosynthetic rate, seed size. Large-genomed lineages with stronger biophysical constraints, are predicted to exhibit slower trait evolution compared to small-genomed lineages that, at the whole plant level, can impact where they can and cannot grow. High nutrient demand of large-genomes can also restrict species’ range size in nutrient-poor conditions. But it remains unclear how genome size’s effects on trait flexibility and diversification, influenced by abiotic factors, impact range size. I will address this knowledge gap by establishing a single quantitative framework using the widely distributed palm family (Arecaceae) as a model system. Palms possesses considerable genome size and trait diversity. A major methodological challenge of obtaining genome size data will be addressed by developing a method to predict genome size from leaf stomatal guard cell size. With a secondment and collaborating with a team of leading experts, I will expand my expertise on cytogenetics and evolution while acquiring new skills on ecological analyses, and develop my supervisory and leadership skills. Together, this project will lay the foundations for my future role as an independent group leader in plant evolutionary ecology with a focus on cytogenetics, to aid in conservation efforts.

Mots clés : range size, genome size, biogeography, distribution, palms, herbarium, plant traits, abiotic factors, ecological modelling, adaptability, macroecology

Participants :
- Naturalis Biodiversity Center (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 217076.16 €
- Royal Botanic Gardens, Kew (Royaume-Uni) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet MASSIVEBAYES (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The massive black holes (MBHs) that we currently observe in the center of galaxies are the final stage of a complex evolutionary path in which seed BHs at high redshift grow in proto-galaxies through episodes of merger and accretion. If MBHs are brought sufficiently close during a galaxy collision, they can merge, emitting gravitational waves (GWs). In 2034, the Laser Interferometer Space Antenna (LISA) will observe the GWs from merging MBHBs across the entire Universe, providing exquisite estimates of the binary parameters. As astrophysical processes, such as gas accretion, supernova feedback and dynamics, leave an imprint on the MBHBs masses, merging redshift, spins and eccentricity distributions, detecting MBHBs will provide us indirectly information on MBHBs formation and evolution scenarios. The scope of the project is to asses LISA ability to constrain the MBHBs astrophysical and formation mechanisms, combining state-of-the-art simulations to predict the MBHBs population with reverse Gaussian process and hierarchical Bayesian analysis. We plan to implement a semi-analytic model (SAM) to describe the complex processes shaping the MBHBs distribution and to model astrophysical processes and formation scenarios with population hyperparameters. We will construct a grid in the hyperparameter space where each node will correspond to a realistic population of MBHBs. These points will serve as a template bank for a Gaussian Process interpolator, which in turn will be the backbone of a hierarchical Bayesian inference framework. This framework will be employed to extract the posterior distributions of the population hyperparameters with the final goal of inferring the contribution of different astrophysical processes to the MBHBs population.

Mots clés : black hole binaries astrophysics, lisa, bayesian inference

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet NanoPep4IBD (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Inflammatory bowel diseases (IBD) affect more than 2 million residents in Europe. Currently, there is no cure for IBD, and treatment focuses on alleviating symptoms. Injured/compromised mucosal barrier and GI biofilms are common pathophysiological deviations in IBD. The overall aim of this project is to develop gut-stable peptides effective against biofilms, peptides suitable for wound-healing treatment, and nanocarrier systems for targeted delivery. In particular, I will focus on developing new antibiofilm peptides, based on the existent cathelicidins, and also develop GI wound-healing peptides based on the trefoil factor family (TFF). Cathelicidins and TFF peptides occur naturally in humans, and defects in these response systems can lead to GI diseases. Hence, in this project I aim to: (i) design, synthesize and characterise novel gut-stable antibiofilm and wound-healing peptides, and (ii) develop nanoparticle drug-delivery systems for their targeted application. Based on peptidomimetic synthesis, I will produce peptides containing unnatural amino acids, loop and helix mimetics, and also retroinverso analogues. Chitosan-coated liposomal and silica nanoparticles will be used for targeted colon treatment, as multifunctional systems: nanocarriers protect the peptides, chitosan enables mucoadhesive release, and chitosan has also beneficial anti-inflammatory, wound-healing and antimicrobial effects on its own. High regioselectivity and limited off-target effects can be achieved by using gut-stable peptides targeting local sites of inflammation, compromised gut epithelium and biofilms, since they are too large to cross the gut barrier. Orally administered peptide drugs targeting colonic tissues represent a highly innovative and safe route in treating GI disorders.

Mots clés : inflammation bowel diseases, drug delivery, liposomes, mesoporous silica nanoparticles, cathelicidins, trefoil factor family peptides, peptidomimetics

Participants :
- Université de Vienne (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183600.96 €
Projet SONA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Signal transduction of diverse inputs often relies on a comparatively small number of central signal integrators. The resulting question, how such a central signal transmission protein can recognise the specific input and trigger the respective, appropriate outputs is as of yet unresolved. However, recent research focusing on plant signal transduction suggested that the precise spatiotemporal organisation and the organisation of signalling modules into membrane nanodomains could play a crucial role in achieving signal specificity. A prime example in Arabidopsis is the GTPase RHO OF PLANTS (ROP)6 that forms nanodomains in the auxin-mediated gravitropic response as well as in osmotic stress. In SONA, I will use ROP6 as model system for membrane organisation at the nanoscale to dissect the self-organising principles of nanodomain formation and function. My host group and collaborators discovered how ROP6 assembles into nanodomains, which will be the foundation for a detailed and innovative characterisation of how protein-lipid interplay contributes to nanodomain specificity. Based on preliminary results, I will use live super-resolution microscopy to investigate how and where ROP6 nanodomains are nucleated after auxin and hyperosmotic treatment, respectively. In addition, I have two parallel, complementing goals in identifying the membrane lipids necessary for sustaining the nanodomains and the protein components required for feedback loops and specificity in ROP6 nanodomain signalling. Taken together, SONA will give insights into the membrane organisation of ROP6 nanodomains at unprecedented spatiotemporal resolution. It will also challenge our understanding of the signal transduction at the plasma membrane by emphasising how self-organising principles contribute to the formation of specific signalling modules. Finally, this action will provide me with valuable training to develop into an independent researcher in the field of plant lipid and membrane research.

Mots clés : plant membrane nanodomains, auxin, osmotic stress, receptor kinase, lipid signaling, rho gtpase, arabidopsis, roots, proximity labeling, lipidomics, single molecule super resolution microscopy

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet TissueLymphOmics (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Formation of Tertiary Lymphoid Structures (TLS) is a recurring consequence of chronic tissue inflammation and autoimmunity, as well as several solid tumours. TLS originate in various tissues from infiltrating cells attracted by local signalling cascades. These structures can enhance local immune response by, similarly to Secondary Lymphoid Organs (SLO), functioning as spots for lymphocyte activation upon antigen recognition. However, the cellular interactions driving TLS emergence and function across tissues are not fully known. This proposal aims to unravel and characterise the cell-cell interactions involved in the formation and maintenance of TLS, in particular their tissue specificity and relationship to autoimmune diseases. A comprehensive understanding of intercellular interactions will be obtained from publicly available and newly generated single-cell RNA-sequencing (scRNA-seq) datasets from TLS-containing tissues of autoimmunity patients. Molecules involved in key signalling interactions will be spatially resolved by assessing their tissue expression using spatial transcriptomics. Then, using mouse models where TLS triggering can be controlled, scRNA-seq data will be obtained to outline a time course of TLS formation in different tissues, revealing the temporal role of the discovered interactions and their specific function in each tissue and when compared with SLOs. Finally, regulation and downstream effects of ligands and receptors will be unraveled with multiome (RNA+open chromatin) sequencing using human tonsil organoids. The observed effects will be generalised to other tissues using machine learning and deep learning models, resulting in a tissue-specific reference of signalling and regulatory genes controlling TLS biogenesis. Overall, this project aspires to provide a detailed look into TLS biology, while defining the bases for their therapy-oriented manipulation.

Mots clés : tertiary lymphoid structures, tissue specifity, scrna seq, cell cell communication, autoimmunity

Participants :
- Gulbenkian Institute for Molecular Medicine (Portugal) — Coordinator, beneficiary, Recherche, subvention : 156778.56 €
Projet EcoEvo-DynaMosaic (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

In the last two decades, studies have revealed that evolutionary changes can occur rapidly on ecological timescales. This indicates that ecological and evolutionary processes can interact and influence one another; this phenomenon is called eco-evolutionary dynamics. For eco-evolutionary dynamics to occur, populations need to harbour sufficient standing genetic variation. Many factors influence genetic variation, one of which is spatial population structure. Many populations living in heterogeneous landscapes occur as spatially subdivided populations connected by dispersal, known as metapopulations. Habitat network structure (spatial configuration of habitat patches) influences not only the demography of metapopulations but also the distribution of genetic materials by mediating population size and gene flow. This implies that eco-evolutionarily dynamic responses may be spatially unevenly distributed in heterogeneous landscapes. The mosaic of eco-evolutionary coupling could be partly predictable from habitat network structure and the movement of organisms. The goal of this project is to investigate how habitat network structure can shape the spatial structure of standing genetic variation in metapopulations and, consequently, how it can influence spatial eco-evolutionary dynamics. This project will build a theoretical understanding of the effects of major dimensions of habitat network structure on genetic variation and local adaptation in metapopulations. The model will be applied to ecologically and genetically well-characterised empirical metapopulations studied by the supervisor. This project will combine eco-evolutionary metapopulation modelling and genomic and field population data to mechanistically understand the role of space in eco-evolutionary dynamics. I will conduct research in France for the first time, gain new skills in genomics and population genetics, and sharpen and transfer my existing modelling and remote sensing skills at the host organisation.

Mots clés : eco evolutionary dynamics, mathematical and computational modelling, spatially structured populations, metapopulations, metacommunities, population genetics, genomics

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet De-CAF (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Communication between different cell types is essential for many biological processes, both in homeostasis and in disease. In tumor initiation, growth and metastasis, cancer cells send and receive chemical and physical cues from their microenvironment. Those cues determine how disease progresses and influence proliferation and invasiveness of malignant cells. Understanding the crosstalk between cancer cells and their immediate environment is crucial for the advance of novel cancer therapies. Thanks to the development of single-cell technologies, we can now sample the complexity and the many functions of the tumor microenvironment. While immune cells are at the forefront of these studies, the mesenchymal fibroblast component is also a highly pertinent and significant player. In this proposal, I will focus on proximal communication between cancer cells and mesenchymal fibroblasts. Using intestinal cancer as a model, I will apply a multimodal approach to investigate the consequences of tissue crosstalk in the early stages of epithelial transformation and the activation of cancer-associated fibroblasts (CAFs). First, I will use tumoral organoid-naive fibroblast co-cultures to study the crosstalk between epithelium and mesenchymal fibroblasts in vitro, and its effect on fibroblasts gene expression pattern (objective 1). Secondly, I will interrogate the response of mesenchymal fibroblasts to epithelial transformation in vivo at single cell depth. I will identify new fibroblasts subpopulations (CAFs), study their origin and transcription factors involved in their activation (objective 2). Finally, I will study the tissue re-organization induced by crypt hyperproliferation using high-resolution confocal imaging and in situ hybridization, to spatially contextualize any changes in gene expression (objective 3). Results from these three objectives will enhance understanding of cellular crosstalk in early stages of cancer and the mechanism of CAFs activation.

Mots clés : cellular crosstalk intestinal cancer pdgfra mesenchyme fibroblasts organoids imaging

Participants :
- University of Veterinary Medicine Vienna (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183600.96 €