Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet UNRAVEL (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

In the model plant Arabidopsis thaliana, the integration of complex developmental and environmental cues to determine flowering time occurs via tight regulation of FLC. During winter, prolonged cold quantitatively down-regulates FLC expression at the whole-plant level, acting via a cell-autonomous epigenetic switch. A long non-coding RNA, COOLAIR, is transcribed antisense to FLC and plays a key role in this switch. COOLAIR knockout lines show slower silencing of FLC in the cold and altered chromatin modification dynamics. However, the mechanism by which this is achieved remains unclear. My objective is to determine the relationships between COOLAIR transcription, secondary structure and function in the epigenetic silencing of FLC. I will determine in vitro and in vivo secondary structures for COOLAIR in two natural A. thaliana alleles with functional differences in FLC silencing and flowering time. Using both natural alleles and site-directed mutagenesis to disrupt COOLAIR secondary structure, I will assess resulting FLC silencing and flowering phenotypes to investigate the structure-function relationship. Finally, I will develop a method for identifying specific protein-binding partners and sites in COOLAIR. This research will significantly enhance our knowledge of the mechanism underlying cold-mediated silencing in FLC specifically, and of the integration of long-term environmental signals in plants in general. More broadly, it contributes to our emerging understanding of the role of lncRNAs in an epigenetic silencing mechanism that is conserved across the higher eukaryotes. This proposal is directly relevant to the Horizon 2020 Work Programme goals: developing my creative potential and diversifying competences through international mobility and advanced training in technical and transferable skills; enhancing contact networks for both myself and my host organization through academic, commercial and public engagement; and catalysing significant career development.

Mots clés : arabidopsis, epigenetics, flowering time, rna structure, proteomics, lncrna

Participants :
- UK Research and Innovation (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 195454.8 €
Projet TeAMH-Robot (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In the near future, the advent of robots will change the role that artificial agents play in our life, as the interaction with them will not be limited to specialized and well-structured work environments. When interacting with artificial agents, humans often occur into the Out of The Loop phenomenon (OOTL), that is a difficulty to predict and prevent failures, probably due to a lack of transparency in artificial agents actions. The overarching aim of TeAMH-Robot is to develop a model of Human-Robot Interaction (HRI) that will prevent the OOTL phenomenon when interacting with robots. To this end, TeAMH-Robot will use a novel approach to develop efficient HRI that combines cognitive neuroscience methods with real-time interactive tasks with a humanoid robot. Firstly, TeAMH-Robot will aim to understand how temporal adaptation and anticipation mechanisms allow humans to “stay in the loop” when mistakes occur. Then, TeAMH-Robot will use this knowledge to develop a human-inspired module for humanoid robots that ensure real-time coordination. Finally, TeAMH-Robot will test the efficiency of human-inspired behaviour in reducing the impact of the OOTL phenomenon. The outgoing phase will be hosted by the Western Sydney University (Australia), where the ER will (i) identify and (ii) model temporal adaptation and anticipation mechanisms that allow humans to predict, prevent and recover mistakes. The return phase will be hosted by the Italian Institute of Technology (Italy), where the ER will (iii) develop a module for humanoid robots that ensure real-time coordination and (iv) test its efficiency in reducing the OOTL by means of the acquired neurocognitive methods. TeAMH-Robot will increase ER’s expertise on social cognitive mechanisms and allow her to start her independency. Moreover, the fellowship will enable the ER to build an international and interdisciplinary network. The results of TeAMH-Robot have the potential to promote the exploitation of robots in everyday life.

Mots clés : sensorimotor synchronization, human robot interaction, out of the loop phenomenon

Participants :
- University of Western Australia (Australie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 171473.28 €
Projet DynaCatMe (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

In the next decades, methane will be used extensively in the European Union owing to the increased supplies of shale gas. Methane is the main component of natural gas (>90%) and its combustion is more efficient and has less carbon footprint with respect to other carbon-containing fuels. However, it is a powerful greenhouse gas, with an effect 20 times higher than that of CO2 and its high-temperature combustion emits toxic NOx and CO. Decreasing the emissions of greenhouse gases from combustion engines requires the development of more efficient catalysts, which is critical for natural gas fueled vehicles (NGVs). My main goal in DynaCatMe is to develop highly active and steam-tolerant methane abatement catalysts. Based on outstanding preliminary results of the host group, I will synthesize the nanomaterials by using an unexplored method in emission-control catalysis: Mechanochemistry, which is a cheap, eco-friendly and readily scalable method and where active sites with unconventional architectures are created. During this Fellowship, I plan to acquire a fundamental understanding of the structural and chemical properties of the novel catalysts to precisely identify the active sites responsible for the superior performance. In addition, I will investigate the dynamic nature of nanocatalysts by using cutting-edge synchrotron-based operando spectroscopies to monitor and decipher their actual working state under industrial reaction conditions. Importantly, the expected results will also have a strong impact on methane-activation technologies for industrial application. I will build on my previous expertise in advanced characterization and will be guided by an expert in catalysts synthesis, characterization and testing to bring this multidisciplinary project to fruition. During the implementation of the Fellowship, I will develop new technical and transferable skills via a specifically designed and documented training plan.

Mots clés : methane abatement technologies, operando spectroscopy, nanocatalysts, novel architectures, interfaces, micromonolith

Participants :
- Universitat Politècnica de Catalunya (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet Shape Evolution (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

In the past 100 years, various theoretical approaches have been proposed to model the complex strong interaction between the neutrons and protons in a nucleus, however, a thorough understanding of its quantum structure is still far from being complete. Studies of the evolution of nuclear structure in mass regions away from the valley of stability have revealed dramatic modifications of the ordering of single-particle orbitals in exotic nuclei as compared to the ones predicted by the Shell Model. These surprising results have prompted the need for a detailed study of exotic nuclear systems in order to identify the driving forces behind them. The experimental study of these highly unstable exotic nuclear systems is extremely challenging and have become possible only recently due to the advent of radioactive ion beam facilities and highly efficient detection systems. This research project proposes to study neutron rich exotic nuclei in mass A~100-110 region though gamma-ray spectroscopy using fusion-fission and Coulomb excitation experiments. The experiments will measure the lifetime and static quadrupole moments in these nuclei, which will allow a determination of the shape and deformation of the nucleus. The results of these measurements will allow for a stringent test of various nuclear structure models. A study of shape evolution in these nuclei may also help in understanding the residual interactions responsible for changing shell structure in neutron rich nuclei. The experienced researcher will acquire new knowledge and training in nuclear structure physics and in innovative instrumentation, complementing her current expertise. She will learn about various aspects of experiment with radioactive ion beams and new data analysis techniques. She will also get the opportunity to improve her abilities in communicating scientific information to the scientific community as well as to the wider public.

Mots clés : nuclear structure, coulomb excitation, lifetime measurement, gamma ray spectroscopy

Participants :
- Commissariat à l’énergie atomique et aux énergies alternatives (France) — Coordinator, beneficiary, Recherche, subvention : 185076.0 €
Projet TICOH (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

In the past decade, more and more heterogeneous processors are equipping modern supercomputers. Unfortunately, despite the progress of hardware infrastructure, the utilization of heterogeneous computing is still relatively low in practice. The utilization mainly suffers from two bottlenecks: distributed memories that bring high cost for software engineering and degraded performance, and lack of heterogeneity-oriented scalable approaches for irregular problems. The objective of the project TICOH is to address the issue of currently unsatisfactory utilization of heterogeneous computing for irregular problems such as graph and sparse matrix processing. Following a multi-level approach which bridges the domains of performance measurement, benchmark data analysis, modeling, data structure construction, algorithm design and application integration, TICOH will explore best practices that toward the best performance for irregular computations on the best hardware selection. Specifically, the main focus of the project will be to (a) identify and understand bottlenecks of current heterogeneous computing, (b) benchmark and model heterogenous processors composed of CPU, GPU and high-bandwidth memories, (c) design and evaluate new data structures and algorithms for irregular problems aiming for fully use computing and memory resources, and (d) integrate and apply the newly designed approaches for high-level applications. By empirically investigating these issues, the ultimate goal of the project is to allow a broad range of real-world applications to further benefit from heterogeneous hardware in the new era. Prof. Anne C. Elster will be hosting this action at the HPC-Lab of NTNU. Her research team is known for its experience with heterogeneous computing, and is one of the main partners in the H2020 CloudLightning project. This environment will guarantee successful bidirectional transfer of knowledge.

Mots clés : heterogeneous processor, graph processing, sparse matrix computations, irregular problems

Participants :
- Norwegian University of Science and Technology (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 208400.4 €
Projet ACTrans (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

In the post–genomic era, innovation policies in biomedicine are increasingly being driven by the notion that constant advancements in biological knowledge fail to materialize into tangible therapeutic outcomes. Discursively framed in terms of a “gap” between “bench” and “bedside” in need of urgent “bridging”, this representation of the shortcomings of biomedical innovation has propelled growing efforts tailored towards the clinical translation of research results. In the European Union, the acceleration of clinical translation has been positioned as a cornerstone of its innovation strategy, as attested by the launch of a host of translational policy initiatives and a vast array of regulatory reforms in the process of medicines approval. However, in spite of its growing relevance, the broader expectations, dynamics and implications of the translational enterprise at EU level have yet to be comprehensively drawn out by the social sciences. This project sets out to accomplish this objective. Drawing from qualitative research methodologies, it investigates the articulation of translational initiatives in the policy and regulatory context of the EU, with the aim to chart and analyze the different epistemic and normative expectations underpinning translational policies, the sociotechnical dynamics of their implementation, as well as their social and political implications. Specifically, the project focuses on the mobilization of translational initiatives into the service of EU socio–political consolidation and its transboundary exercise of political, economic and cultural power, and will investigate the possible tensions and trade–offs between the political ideal of competitiveness enshrined in such initiatives, and those of democratic accountability and social justice.

Mots clés : clinical translation, biomedical innovation, european union

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €
Projet SpinMan (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

In the proposed project “Electrical Spin Manipulation in Atoms and Molecules” (SpinMan), the experienced researcher Dr. Andrea Droghetti (Trinity College Dublin , Ireland) and the scientist-in-charge Prof. Angel Rubio, Head of the Nano-Bio Spectroscopy group at the University of the Basque Country (Spain), aim at establishing how an electrical current can be utilized in order to write and read information in a spin state of an atom or a molecule. This study will be carried out through simulations performed with a computational platform, which will combine recent theoretical developments in density functional theory for open systems, many-body physics and time-dependent methods thus bridging the gap between complementary approaches to quantum transport. The results will represent an important step-forward in understanding the basic physics of magnetism and spin dynamics at the nano-scale as required in order to provide, in the long term, new concepts for classical and quantum information. The skills in many-body physics and time-dependent simulations that the researcher will develop during the project, combined with his background knowledge in magnetism and with the acquired experience in networking and management, will be essential in order to advance the researcher's career as independent investigator.

Mots clés : spintronics, molecular electronics, density functional theory, many body theory, time dependent quantum physics

Participants :
- University of the Basque Country (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 158121.6 €
Projet SASPRO 2 (Horizon 2020, appel à projets 2019)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

In the proposed project, Slovak Academy of Sciences (SAS), Comenius University in Bratislava (UK BA) and Slovak University of Technology in Bratislava (STU BA) (together participating organisations) intend to build up mobility programme SASPRO 2 for outstanding researchers allowing them to work at their institutions/faculties. It is an extended continuation of the previous successful SASPRO Programme. The main objectives are to create optimal conditions for fellows to perform their research and boost their career as well as to enhance quality of Slovak science and research by increasing excellence of their organisations. Fellows will freely choose from a wide spectrum of host organisations covering technical and natural sciences, life sciences as well as humanities and social sciences. Cross- and intersectoral, multi- and interdisciplinary and international aspects of the individual projects as well as training provided will be strongly emphasized. Top scientists from abroad will be selected for fellowships; fellows will enrich research teams/organisations and they will contribute to raising the quality level of Slovak and European science and research. On the other hand, host/participating organisations will provide all tools for their career and personal development and ensure broadening and deepening of their scientific and non-scientific experience and skills. The results of the programme realisation will be establishing a quality international cooperation network, building and strengthening the bridges between different sectors, finding new approaches to tackle with research topics, training future leading researchers that will transfer the knowledge further and by that strengthen the European science and research position in the world and reduce its fragmentation.

Mots clés : mobility, excellence, slovak republic, experienced researchers, incoming, reintegration, multidisciplinarity, intersectorality, transfer of knowledge

Participants :
- Slovak Academy of Sciences (Slovaquie) — Coordinator, beneficiary, Recherche, subvention : 4303260.0 €
Projet HNSKMAP (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

In the proposed research, we will devote to the mathematical and numerical analysis of kinetic models. Kinetic theory has wide applications in physical and social sciences, such as plasma physics, semi-conductors, polymers, traffic networking etc. On the one hand, we want to propose and analyse systematic numerical methods for nonlinear kinetic models which have some challenging difficulties such as physical conservations, asymptotic regimes and stiffness. On the other hand, applications to plasma physics will be investigated, which are mainly high dimensional problems with multi-scale and complex geometries. Moreover collisions between particles for large time scale simulation need to be taken into account. We would like to develop a class of less dissipative high order Hermite methods together with weighted essentially non-oscillatory (WENO) reconstructions to control spurious numerical oscillations, and high order asymptotic preserving (AP) discontinuous Galerkin (DG) schemes with implicit-explicit (IMEX) time discretizations for multi-scale stiff problems under unresolved meshes. More importantly, these developed numerical methods would satisfy the positivity preserving (PP) principle, such as positive density distribution functions for kinetic descriptions, which is often violated by high order numerical methods with physical meaningless values. This project will combine the expertise of the Experienced Researcher Dr. Tao Xiong in high order PP flux limiters and high order AP DG-IMEX schemes, and the Host Dr. Francis Filbet in mathematical modellings and numerical tools for kinetic equations. The developed approaches will be translated to the study of turbulent plasma physics such as 4D drift kinetic, 5D gyro-kinetic and 6D kinetic models etc.

Mots clés : numerical scheme, kinetic model, plasma physics, high order, vlasov boltzmann, imex, hermite weno, positivity preserving

Participants :
- Université Claude Bernard - Lyon 1 (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Toulouse (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet ASymmetryNamedCP (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

In the recent years, measurements of rare B decays involving b->sll transitions have shown discrepancies compared to predictions of the Standard Model of Particle Physics. These transitions are flavor-changing neutral currents (FCNC): they are forbidden at tree level in the SM and therefore sensitive to contributions of new particles in loops. Global fits to these data suggest new physics contributions that can be explained new physics models involving a tree-level exchange of a lepto-quark or a flavor changing $Z^\prime$ boson. In the decay of neutral Bs meson to a CP eigenstate, the interference between the decay and the B-meson mixing leads to additional observables that are not accessible to flavor specific final states. In the SM, all CP-violating effects are expected to be very small, therefore these observables can make powerful contributions to our understanding of the B-anomalies as they can differ significantly depending on the properties of new physics contributions. This project will measureme the CP violating observables arising in the interference of the decay and mixing of Bs mesons using a tagged analysis for the first time in phimumu decays using full LHCb data set which corresponds to 9 inverse-fb. Additionally a new method to calibrate decay time resolution at LHCb will be developed and tested on run 1-2 data collected at LHCb and will be ready to use for the run 3 which is expected to start at the end of 2021.

Mots clés : lhcb cpv b anomalies time dependent decay time time resolution rare decays flavor physics

Participants :
- University of Zurich (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €