Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MMOF4PPS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Research and development on high performance (in terms of stability and robustness) and conceptually innovative catalysts is essential to answer the increasing demand of sustainable chemicals and to achieve the European goal of energy consumption reduction, energy security improvement and competitiveness. In this regard multi-molecular catalyst with efficient electronic conductivity is emerging as a prominent research area. Mixed-metal metal organic frameworks (MM-MOFs) indeed exhibit excellent ability to deliver superior photocatalytic activity with improved temperature stability and robustness in harsh conditions, compared to homometallic systems. However, the understanding of these materials is still in its infancy. It is thus crucial to couple the synthesis of tailor-made multi-material systems with high-resolution characterization techniques and reliable surface science models, to obtain a deep understanding of emergent chemical and physical phenomena that are otherwise inaccessible with a single material catalyst. The main objectives and actions of MMOF4PPS will thus be to: (a) explore and optimize synthetic procedures for MM-MOFs, (b) decipher the ultrafast photo-processes inside MM-MOFs, (c) study the effect of varying ratio of metal clusters on the photocatalytic performance, (d) gain detailed knowledge of the effectiveness of MM-MOFs over single metal MOFs in photocatalysis and (e) develop structure–(photocatalytic) activity relationship. Such information represents a steppingstone for the optimization and acceleration in the development of sustainable catalysis, and is thus expected to have significant industrial and socio-economic impacts. In addition, both experienced researcher and host will benefit from establishing interdisciplinary research and deliver research excellence to academia and industry.

Mots clés : mofs, photochemistry, femtochemistry, photocatalysis, laser spectroscopy and microscopy

Participants :
- University of Castilla-La Mancha (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160932.48 €
Projet REMEDHY (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Research continues to demonstrate that people of all ages and abilities enjoy higher levels of health and wellbeing when they have nature nearby in parks, gardens, naturalized schoolyards as well as landscaping at home and work. Access to and engagement with nature is associated with greater longevity, more physical activity, restoration from stress, and a greater sense of wellbeing. However, urbanization and changing lifestyles are compromising our interactions with natural environments and such changes have dramatic implications for mental health and overall wellbeing. Finding our way back to health, through the structures where we live, work, play and learn, requires empirical research that establishes the intermediate processes that link the structures that exist in a person’s environment and the health promoting behaviors that lead to positive health outcomes. This project examines the neighborhood qualities that shape people’s perceptions of place and, in turn, motivate them to engage with structural aspects of their neighborhoods that promote health and well-being. We will use a spatial analytic approach and data from the Positive Effects on the Natural Outdoor Environment in Typical Populations of Difference Regions in Europe (PHENOTYPE) study (n=3947 participants), objective environmental data (n=290 street audits), and in-depth interview data (n=83 interviews) to assess spatial patterns in resident ratings of neighborhood quality and environment and the resident and neighborhood factors that influence these ratings. Additionally, we will use participatory planning techniques to partner with community to design and pilot an intervention that taps into the processes critical for improving health. This research is important because it will provide empirical evidence that community planners, park developers, neighborhood organizations and health practitioners need to support the creation and maintenance of healthy places and healthy people.

Mots clés : built environment, aesthetics, health behaviors, community engaged research, lifestyle intervention, epidemiology, mental health

Participants :
- CERCA Institution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 170121.6 €
Projet MolDesign (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Research in organic electronics has already generated important applications, such organic light emitting diodes (OLEDs) in mobile displays that are already indispensable in our everyday life. Other applications, such as large scale displays and lighting, lightweight and flexible organic photovoltaics, carbon-based electronic paper, organic sensors and RFID tags, are under intense investigation. The multifunctional character of these applications poses enormous challenges for the development of novel materials, which are hard to meet with the present day trial-and-error strategies. The MolDesign project thus aims at computational material design by combining accurate but involved materials simulation methods with inexpensive novel machine learning methods to enable large scale guided materials screening. These methods will be used to improve small-molecule organic semiconductors, which are used as absorber materials in vapor-deposited organic solar cells. While some materials of this class are almost at the photovoltaics market, there is much room for improvement regarding properties such as charge carrier mobility as well as the integration of organic material into completely new applications, such as hole transport materials in highly promising perovskite solar cells.

Mots clés : organic electronics

Participants :
- Karlsruhe Institute of Technology (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 208963.5 €
- Harvard University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Toronto (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet VegProtein (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Research is now focused on the potential contribution of plant-based proteins to help solve key issues pertaining to global food security. Protein hydrolysates have numerous properties which make them an attractive protein source in human nutrition and are utilized in many commercial food applications. Hydrolysed vegetable proteins (HVP) have demonstrated bioactive and techno-functional properties that can be further exploited for the development of functional-foods. The HVP market is dominated by soy varieties, and there is now a growing demand for alternative plant based sources. However, significant research advances are required in order to increase the direct use of plant protein for human food consumption, with a particular emphasis on extraction and processing technologies used to derive increased nutritional value and improved functional physical properties. From a commercial standpoint, vegetable proteins have taste attributes such as chalkiness and bitterness which present a major challenge in commercialization. This project will address the significant potential for application of superior tasting vegetable protein hydrolysates with improved food use properties for the functional foods market globally; this will be achieved by investigating the efficacy of a range of commercially available proteases in producing HVPs under controlled enzymatic conditions using a variety of vegetable substrates. Degree of hydrolysis, protein recovery, chemical composition and techno-functional properties of HVPs will be compared/contrasted before further optimization of characters, e.g. de-bittering, solubility, necessary for the their implementation in end use markets. Our primary goal is to engineer a clean tasting HVP with improved sensory and techno-functional capacity and an enzyme system suitable for its production.

Mots clés : enzymes, protein, hydrolysates, food security, vegetable

Participants :
- Kerry ingredients (ireland) limited (Irlande) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 187866.0 €
Projet NVHSC (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Research of the bone marrow (BM) hematopoietic stem cell (HSC) niche has long been the study of mesenchymal cell populations. Only recently, distinct vascular niches have been identified to balance HSC activation and quiescence. Whereas arterioles together with sympathetic nerves and NG2+Nesbright cells form a niche for quiescent HSC, actively proliferating HSC are closely located to sinusoidal vessels and LepR+Neslow cells. However, it is still elusive how different blood vessels interact with different niche cells in distinct vascular niches during BM homeostasis and leukemic progression. Therefore, the present proposal aims at studying the role of distinct vascular BM niches in controlling HSC maintenance and malignant progression by means of genetic mouse models, FACS analysis, high resolution whole mount BM imaging and RNA sequencing. Besides investigating the direct influence of EC on HSC in different vascular niches, the interaction of EC with perivascular MSC and particularly neurons will be compared between the sinusoidal and arteriolar niche under steady-state and malignant conditions. Changes of the vasculature and downstream effects on HSC and other niche cells will be analyzed during therapeutic targeting of leukemia and the vascular compartment will be evaluated as novel target for niche-targeting leukemia combination therapies.

Mots clés : hematopoietic stem cell, vascular niche, blood vessels, bone marrow, neurovascular link, sympathetic nerves, leukemia, chemotherapy, anti angiogenic therapy

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet TWSCC (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The Wnt cascade is an evolutionary conserved pathway that controls cell proliferation, differentiation and growth. Although mutations to this pathway are commonly associated with certain cancers (e.g. colorectal/breast cancer), other mechanisms that control Wnt activity, e.g. its intracellular trafficking regulation, has not received significant attention in the past. The objective of this fellowship is to use my existing knowledge of cell biology to map the trafficking routes that Wnt components take in normal cells, and to test if these routes are altered in cancers to sustain their proliferative capacity. This project will combine bioinformatic analysis to find lead candidates to further investigate in the model organism Drosophila melanogaster. By generating novel fly strains and using high-resolution imaging, I aim to advance our understanding on how Wnt components are trafficked in vivo.

Mots clés : cell biology, wnt signaling, drosophila genetics, cancer cell lines, organoids

Participants :
- German Cancer Research Center (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 162806.4 €
Projet MOSAICS (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : SIGNED

The World Health Organisation (WHO) states that 6.1% of the world’s population – 466 million people – has disabling hearing loss, and approximately one-third of people over 65 years of age are affected by it. For people with severe to profound hearing loss, a cochlear implant (CI) is the preferred treatment. However, one of the hallmarks of adult CI outcomes is the enormous variability reported in auditory, speech and language functioning after implantation. Enhanced performance in adult CI users will increase quality of life and allow them to engage more in society, uphold social bonds, independency and jobs. The scope of the MOSAICS European Industrial Doctorate (EID) is to understand, predict, identify, and intervene within in the variation of adult CI users by making use of a holistic and multi-disciplinary approach, bringing together experts from engineering, neuroscience, biophysics, psychology and sociology. Research will be targeted at levels ranging from cochlea to brainstem and auditory cortex, in order to assess the effect of cognition on the performance with CI and vice versa. In addition, societal effects of improving audition and communication after implantation will be investigated. The MOSAICS research and training programme is jointly managedan EID driven by Cochlear, the largest global manufacturer of hearing implants, and the Radboud University Medical Centre, hosting Europe’s leading academic groups in hearing related research, as beneficiaries. Their expertise is complemented by several partner organisations, including four other research groups, two highly specialized SMEs and the European patient organization for cochlear implant users. Synergiesy between both industry and academic partners will enable four early stage researchers ESRs to contribute to the hearing-related innovations and to face the challenges within adult CI care during the entire hearing journey within a highly productive, engaging, and exciting training network.

Mots clés : hearing, cochlear implants, holistic framework, participation to society, maximizing outcome in speech perception outcomes, medical engineering, neurocognition, objective measures

Participants :
- Radboud University Nijmegen (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Radboud University Nijmegen Medical Centre (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 531239.76 €
- Cochlear (Australia) (Belgique) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 512640.0 €
Projet 2DTriCat4Energy (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The World is currently in a state of an energy and climate crisis. The World’s fossil fuel reserves are predicted to be depleted in the next century. Due to this and the increase in global warming, EU policies have called for the decrease use of carbon-based fossil fuels and the development of alternative energy resources. Hence, it is of paramount importance to conduct research into alternative energy conversion and storage technologies now. Electrolytic water splitting is an attractive process for producing clean hydrogen which can be used in a fuel cell to make electricity. The electrochemical energy needed for water splitting and fuel cells could be generated by materials that can hold efficient charge in the electrochemical double layer or in Faradaic regions e.g. supercapacitor materials. Unfortunately, these technologies (electrolysers, fuel cells and supercapacitors) are still under major research as the ‘state-of-the-art’ catalysts currently used are uneconomical. The development and rational design of new, cheap and active electrodes as tri-functional catalysts for these three alternative energy technologies is one avenue to explore to reach the goals set out by the various EU polices. 2D Transition Metal Oxide (TMO) materials may be the answer to this problem, as when compared to their bulk counterparts, 2D materials are more conductive and exhibit interesting properties. Currently, in the literature there are no trifunctional catalysts for the aforementioned alternative energy applications based on 2D TMO materials (source: Scopus, terms: 2D TMO materials/water splitting/ fuel cells/ supercapacitors). Hence this fellowship will investigate just that. The proposed multifunctional energy storage and conversion catalysts, in this fellowship, will be a first in the energy/materials field and will contribute a plethora of knowledge to current literature. I, the applicant, along with the Nicolosi group have the combined tools and knowledge to achieve this.

Mots clés : supercapacitors, transition metal oxides

Participants :
- Trinity College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184590.72 €
Projet TGDNL (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The ability of cells to precisely maintain an internal steady state of lipids is essential for life. While homeostatic mechanisms controlling specific lipids such as sterols are well characterized, the regulation and coordination of fatty acid (FA) and triacylglycerol (TG) synthesis remains largely unknown. Several common metabolic disorders, including obesity and type 2 diabetes, lead to nonalcoholic fatty liver disease (NAFLD), a condition characterized by increased accumulation of hepatic TGs. Since a significant proportion of subjects with NAFLD develop potentially fatal complications, e.g. non-alcoholic steatohepatitis (NASH) and cirrhosis, it is of fundamental importance to study the mechanisms that promote hepatic lipid accumulation. By combining advanced molecular techniques with state-of-the-art clinical research, a translational approach will be applied herein to uncover how cells coordinate glycerolipid and FA synthesis. The studies focus on acyl-CoA:diacylglycerol O-transferase 2 (DGAT2), an enzyme catalysing the final step of TG biosynthesis and a drug target for NAFLD, which according to recent data may play an important role in FA synthesis regulation. The results generated in this project may uncover novel mechanisms controlling cellular lipid homeostasis and provide new therapeutic avenues to treat NAFLD and NASH.

Mots clés : lipid metabolism, glycerolipid synthesis, de novo lipogenesis

Participants :
- Karolinska Institutet (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265059.0 €
- Harvard University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet VSC_CAT (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The ability to selectively alter the energies of specific molecular vibrations has enormous consequences for chemical reactivity. Very recently, the groups of Ebbesen (physical chemistry) and Moran (organic chemistry and catalysis) showed that the rates of simple ground state reactions of organic molecules can be modified through Vibrational Strong Coupling (VSC) of a vibrational mode involved in the transition state of the reaction. However, most aspects of the application of VSC to chemical reactions are still in their infancy and many questions remain. The aim of this proposal is to explore how VSC can be used to modulate the selectivity of simple organic reactions, to understand which functional groups and reaction mechanisms are most susceptible to VSC, as well as to explore the effect of VSC on catalysts and catalytic reactions.

Mots clés : organic chemistry, site selectivity, vibrational strong coupling

Participants :
- Université de Strasbourg (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet REXyCLIMA (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The adverse effects of increasingly warm and dry growing conditions are already pushing traditional and new-world wine-growing regions to their limits,. Since the grape-growing potential of their long-established cultivated grape varieties - and consequently the often strictly regulated quality and typicity of their wines - relies on the mesoclimate of their terroir sustaining a high temporal stability, climate change becomes a major threat. Among the adaptation measures considered, the most urgent is the adoption of climate-resilient grapevine varieties. Certain indigenous varieties found on the island of Cyprus, a natural “open lab” of warm and dry climate viticulture, have been reported to have a very high heat and drought tolerance and deserve consideration for cultivation outside their native region of production. However, their resilience remains yet to a large extent scientifically unexplored. To this end, the researcher will carry out a fellowship to investigate the underlying resilience and physiological adaptive response of the bona fide Cypriot indigenous grape cultivar cv. ‘Xynisteri’ to climate change, with an aim to support with sound scientific data its suitability as a variety to be used as a long-term adaptation measure, from countries where their viticulture is already negatively impacted by increasingly warm and dry growing conditions. The fellowship will be carried out in Zambartas Wineries Ltd as the Host Institution, a pioneering SME tightly aligned with regional Research Units, with targeted secondments at leading in the field Institut des Sciences de la Vigne et du Vin, France and University of Tuscia, Italy. The interdisciplinarity and intersectionality of the proposed project will provide the researcher with a unique opportunity to broaden her knowledge/skills and acquire a truly multidisciplinary methodological scientific perspective of an emerging field like viticulture, allowing her to seek a permanent senior position in viticulture R&D.

Mots clés : horticulture, viticulture, berry quality, ripening, climate change, stress resilience, crop adaptation

Participants :
- Winestories limited (Chypre) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 157941.12 €