Projet NEUcrest (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Neurocristopathies caused by defects in the neural crest (NC) encompass a broad group of diseases from birth defects (cleftvpalate) to complex syndromes affecting systems such as heart, gut and adrenals. Because NC derivatives are diverse, mutations affecting this lineage can lead to pleiotropic phenotypes making it difficult to understand the causative events. Furthermore, NC-derived cancers, (e.g. melanoma and neuroblastoma) reactivate embryonic programs during tumour initiation. Our aim is to create a unique interdisciplinary network of scientists and clinicians partners from academia, healthcare, industry and the public sector with experience in gene discovery, genetics, functional studies and in vivo phenotyping aimed at training creative and innovative ESRs to study the overall genetic, molecular and environmental regulation of NC tissue in human health. To study each of complex aspects of NC and tumour formation, NEUcrest provides a synergistic framework for comprehensive analysis of candidate genes and biological processes, from patients to model systems to pharma and back to the clinic. With the aim to develop a unified strategy to identify new genetic and environmental factors that contribute to disease and to develop new drug targets for therapeutics, ESRs will address following scientific challenges: undertake novel gene discovery approaches; establish cellular/animal models of disease; establish integrative strategies for understanding neurocristopathies; optimise computational modelling of NC gene networks; establish translational strategies for drug screening in NC-related diseases; improve clinical management strategies of NC-disease and interface with patients and the public. Our training program takes into account training through research as well as multidisciplinary partnerships and networking opportunities. All together, this will improve our understanding of the fundamentals of neurocristopathy and contribute to improvements in healthcare.

Mots clés : multidisciplinary training, genetic disorders, genomics and functional genomics, genetic and molecular diagnostic tools, cancer and biological basis, drug discovery, bioinformatics

Participants :
- University of East Anglia (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- National University of Ireland (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 549368.64 €
- Medical University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 264207.24 €
- Tel Aviv University (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 263500.92 €
- Institut Curie (France) — Coordinator, beneficiary, Recherche, subvention : 549604.08 €
- Erasmus MC (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 265619.88 €
- Stemcell technologies uk ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 303172.56 €
- Miguel Hernandez University (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 501809.76 €
- Azelead (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 274802.04 €
- Institut des maladies génétiques (France) — Partner, beneficiary, Recherche, subvention : 274802.04 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €