Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ShelChromTelo (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The linear ends of eukaryotic chromosomes are formed by telomeres, nucleoprotein structures containing double-stranded TTAGGG repeats, ending in a single-stranded DNA 3’-overhang. In mammalian cells, the six-subunits Shelterin complex binds telomeres and is critical for telomere homeostasis. Shelterin ensures faithful replication of telomeric DNA, hides linear ends in a looped structure to prevent their recognition as DNA breaks and ensures control over telomere length. Telomeres are packed into nucleosomes, and therefore Shelterin binds in a chromatin context. Interactions between individual Shelterin subunits and nucleosomes have been investigated in vitro, as well as their impact on chromatin organisation. Despite increasing evidence of a Shelterin-chromatin interplay, many questions remain unanswered. The dynamics, affinities and consequences of full Shelterin complex binding to chromatin are unknown. I will employ single-molecule experiments with optical tweezers and bulk assays to monitor the binding of Shelterin on telomeric chromatin and its impact on nucleosomes (and vice versa). The physiological role of this interplay, as well as its regulation, is also largely unknown. I will investigate the impact of an impaired Shelterin-chromatin interaction on telomere and genome stability, as well as its impact on the telomeric proteome and the epigenetic landscape of telomeres. Lastly, I will examine how the Shelterin-chromatin interaction is regulated during the cell cycle. Altogether, this work will provide fundamental new knowledge on Shelterin recruitment and functions at telomeres. Considering that in recent years Shelterin gained interest as an anti-cancer therapeutic target, this basic knowledge has the potential to guide future research aimed at targeting Shelterin for induction of telomeres dysfunction in cancer cells.

Mots clés : shelterin, chromatin, telomeres, genome stability

Participants :
- Institut Francis Crick (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 260347.92 €
Projet MUNDI (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The MUNDI MSCA project explores the uses of digital innovations for the predictive anticipation, real-time analysis, and early intervention in multiple and intersecting threats to human security in Ghana. Specifically, the project takes the focal areas of Ghana’s multi-sectoral emergency preparedness and response effort – that is, the spread of infectious disease, climate-change related flooding, and man-made disasters in the context of mining activities – as case studies to explore data practices in the country’s national disaster risk reduction (DRR) strategy. Central tools of DRR, including strategic and evidence-based risk assessment, operational plans and risk communication, are directly tied to the systematic and standardized production and analysis of data about populations and their environs. This has raised concerns about data quality in contexts characterized by historically incomplete and fragmented population registers and statistical reporting systems. The MUNDI project seeks to answer the research question how innovations in data practices anchor the acceleration of interventions in human security in spite of multiple and layered uncertainties about data sources, models and predictions. Exploring this question in the context of Ghana will advance our empirical understanding of the base processes and material foundations of building “real-time” datafication in emerging data systems, develop new theoretical approaches to evidence-production under conditions of sustained uncertainty, and add to our methodological toolkit new frames for the comparative analysis of digital population data infrastructuring for the purpose of impact forecasting, early warning, and rapid deployment of first responders.

Mots clés : disaster risk reduction

Participants :
- IT University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet MICROMETER (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Plant-microbiome interactions are crucial for plant health, promoting growth and enhancing resilience under stress conditions. These interactions are highly heterogeneous, shaped by diverse plant cell types and the complex spatial distribution of microbes. However, our current understanding remains predominantly at the tissue level, lacking the resolution to fully capture this heterogeneity. As a result, the genetic networks that govern how plants foster beneficial microbiomes remain largely unexplored. This Fellowship aims to address these gaps by employing cutting-edge single-cell multiomics and spatial mapping technologies. Using Arabidopsis thaliana and the well-characterized 35-member synthetic microbial community (SynCom35) as model systems, I will integrate single-cell transcriptome and chromatin accessibility assays to map transcriptional and epigenetic changes in root cells in response to microbial colonization. This approach will provide novel insights into the cellular mechanisms and genetic networks underlying plant-microbiome interactions. Additionally, by utilizing and further developing PHYTOMap, a multiplexed 3D spatial gene expression analysis platform, I will simultaneously spatially map plant gene expression and microbiome distribution. By integrating single-cell and spatial omics data, I will reconstitute spatially-resolved plant gene regulatory networks that interact with specific microbiome members. Furthermore, I will functionally characterize these predicted regulatory networks, aiming to lay the foundation for genetic engineering to enhance plant interactions with beneficial microbes, offering new strategies for optimizing plant growth and resilience. Altogether, this research will significantly advance our understanding of plant-microbiome interactions at single-cell and spatial resolutions, providing a foundation for innovative approaches to enhance crop resilience and agricultural sustainability in response to global challenges.

Mots clés : plant microbiome interaction, plant immunity, single cell omics, spatial mapping, spatial omics, microscopy, imaging, molecular genetics, signaling pathway, genetic engineering, rhizosphere microbiome

Participants :
- Sainsbury Laboratory (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 260347.92 €
Projet NRG1 phosphorylation (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Plant diseases caused by microbes result in considerable yield losses in agricultural production systems worldwide, thereby endangering food security. To combat invading microbes, plants have evolved a two-layered innate immune detection system: cell-surface receptor-initiated pattern-triggered immunity (PTI) and intracellular nucleotide-binding leucine-rich repeat receptor (NLR)-initiated effector-triggered immunity (ETI). Interestingly, cell-surface receptors are required for full NLR-mediated plant immunity. NLRs are classified as sensor NLRs, involved in effector detection, or helper NLRs, required for sensor NLR signalling. Our preliminary data demonstrate that in Arabidopsis thaliana the helper NLR N REQUIREMENT GENE 1 (NRG1) undergoes PTI-dependent phosphorylation, which plays an important role in NRG1-mediated programmed cell death. This suggests that helper NLR phosphorylation may be a crucial checkpoint for PTI/ETI mutual potentiation. This project aims to unravel the molecular mechanisms by which NRG1 is phosphorylated and how its phosphorylation potentiates NLR-initiated immune signalling. My host institute, the Sainsbury Laboratory (TSL), has all the resources to carry out this research. During my work supported by this fellowship, I will be trained in molecular biology, biochemistry, genetics, proteomics and bioinformatics, which will lay the foundation for my future career as an independent researcher. In turn, I will bring my specific expertise in phosphorylation-based activation of cell-surface receptor complexes in Nicotiana benthamiana and tomato, which is not currently available in my host lab. The findings of this project will advance the understanding of plant-microbe interactions and should provide new strategies for crop protection and plant breeding. Furthermore, I will be equipped with the skills and experience necessary to position myself as a leading independent researcher.

Mots clés : plant innate immunity pattern triggered immunity pti effector triggered immunity eti nucleotide binding, leucine rich repeat receptors nlrs phosphorylation

Participants :
- Sainsbury Laboratory (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 260347.92 €
Projet STRATEGUS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Production manufacturing has drastically changed in the last decade, year after year, it became more complex and tightly integrated with new technologies. The application of new technologies can be safely and properly done during the initial design phases of a new production plant. However, one of the key challenges of this so-called “fourth industrial revolution” is that it must be applied to existing production plants, introducing much more complexity. The goal of STRATEGUS is to provide understandable techniques and software architecture for guiding industrials towards the proper integration of new technologies in their current production plant. STRATEGUS will build the so-called digital twin, a digital representation of the factory plant, that functions as an interface to the sensor data and contains mathematical models of the equipment. The digital twin provides a structured view of sensor data, allowing one to perform timing analysis, make future predictions, and adjust the control strategy. Then, the main orchestrator will be Strategist, a meta-scheduler that has a twofold purpose: 1. estimating the timing behaviour of the events inside the physical plant by harnessing the power of the digital twin, and 2. optimising the activities on the line based on order arrival and reacting to unexpected events and accidents. STRATEGUS takes inspiration for describing the models inside the twin from the theory of multimode systems, where each piece of equipment is modelled as a set of differential or difference equations describing how they manipulate the products’ characteristics until it reaches the state of the finished product.

Mots clés : cyber physical systems, design automation, continuous time simulation, discrete time simulation, advanced manufacturing, optimization techniques, industrial control systems

Participants :
- Université de Caroline du Nord à Chapel Hill (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Vérone (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €
Projet Journal Poetics (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

"Journal Poetics – Literature and Media in the Age of Goethe" Historians of literature consider the so-called Age of Goethe (“Goethezeit”) (ca.1770–ca.1830) an era of male highbrow literature following the idea of the autonomy of art. The project aims at broadening of this perspective. The key to this reassessment is the media of the epoch: the journal became the principal literary medium from the 1770s onwards. The project focusses on three main aspects: (1) a broadening of the concept of literature to include journal literature, thus enabling a consideration of works beyond book publications, (2) a broadening of the circle of authors, since many authors of the time - especially female authors - published precisely in periodicals, and (3) a relativisation of the distinction between Highbrow and Popular Culture in the Age of Goethe. Combining literary history with Periodical and Gender Studies, the project will examine these aspects by developing a new heuristic concept: “Journal Poetics”. The results will be a literary-historical monograph offering a first systematic and in-depth investigation of the subject and a website (FEMJOUR) that address a broader audience providing data and information on the topic. The University of Verona with its research focus, its infrastructure and experience in conducting international fellowships is the ideal location for this two-year interdisciplinary project. The supervisor, Prof. Laura Anna Macor, is an expert on the research topic and a former Marie Sklodowska-Curie fellow. Secondments at the Universities of Queen Mary London (Prof. Dr. Görner) and Vienna (Prof. Dr. Norbert Christian Wolf) complement the fellowship.

Mots clés : age of goethe, german literature, schiller, journals, periodical studies, female writer, popular culture

Participants :
- Université de Vienne (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Queen Mary University of London (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Vérone (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet MINECHPS-SCI (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Spinal cord injury (SCI) is a debilitating health conditions affecting circa 27.04 million people globally including 6.4 million Europeans with serious impact on the quality of life and socio-economic status of the patients. Existing regenerative and rehabilitation approaches are largely palliative and neuroprotective, targeting the spared neural tissue after injury with limited efficacy in regeneration. While the spinal cord has poor regenerative ability, the degenerative processes further complicate the SCI pathophysiology. Hence, no regenerative and rehabilitation approaches, individually, have resulted in complete and near complete functional recovery to date. To fully restore the injured spinal cord's functionality, a coordinated combinational approach addressing particular degenerative processes is necessary. Herein, the fellow proposes to develop a regenerative-rehabilitation combinational approach to maximize the functional regenerative outcome after SCI using minimally invasive injectable electroconductive hydrogels (ECHs) functionalized with neurotrophins (NTs) and anti-inflammatory cytokines in combination with electrical stimulation (ES) and near infrared (NIR) laser stimulation. ES and NIR laser through the ECH will be used to stimulate the neurons and glial cells to enhance regeneration and neuroplasticity as well as for on demand delivery of biologics to target the inhibitory processes. This proposal describes the project's multidisciplinary nature, execution and management of the project by the fellow and the multiple collaborators who will each provide the fellow with cutting-edge research skills. The goals of the fellow’s project place specific focus to ensure that the training of the fellow brings him to a level of competitive scientific excellence at international level.

Mots clés : electroconductive biomaterial, electrical stimulation, light stimulation, immunomodulation, spinal cord injury

Participants :
- Trinity College (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet VOLTEMAG (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Matter can exhibit a complicated phase diagram comprising a large number of different electronic and magnetic states. While phase transitions induced by temperature or pressure variations, doping, and optical pulses have primarily been studied in bulk materials, phase transitions driven by a bias voltage in nano-devices are mostly unexplored. VOLTEMAG will demonstrate how different electronic and magnetic phases can be tuned through the application of a bias voltage when a material is incorporated into a two-terminal nano-device, especially in the case of materials from the strongly correlated oxides family. The researcher Dr. Anita Halder guided by Prof. S. Sanvito and Dr. A. Droghetti at Trinity College Dublin (Ireland) will develop and use a solid theoretical approach based on the Non-Equilibrium Green’s functions, Density Functional Theory and Dynamical Mean-Field Theory to predict and establish the fundamental physics of voltage-induced magnetic (ferromagnetic-antiferromagnetic) as well as electronic (metal-insulator) transitions. Devices relying on electronic phase transitions behave as multi-state transistors and resistive switches, which are currently the key hardware components to implement neuromorphic computers. The results of VOLTEMAG may therefore lead to possible technological developments, apart from their fundamental character. VOLTEMAG will then set up an extended search for new optimal materials for potential applications via machine learning algorithms. VOLTEMAG will merge the researcher’s background in materials modeling with the expertise of the host institution in quantum theory for nano-devices. The applicant will be trained on several theoretical and computational techniques essential for her future scientific career. She will be able to expand her scientific interests by being part of a large and dynamic group and she will become an independent and mature researcher.

Mots clés : mott insulators, non equilibrium green s functions, density functional theory, dynamical mean field theory, material optimization machine learning

Participants :
- Trinity College (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199694.4 €
Projet FeverTime (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Familial Mediterranean Fever (FMF) is the most frequent monogenic autoinflammatory disease worldwide. It is caused by mutations in the gene pyrin which are surprisingly frequent (up to 20%) in individuals of East Mediterranean ancestry. The evolutionary forces behind such a high local mutation load are unknown but it has been suggested as an example of balancing selection with a selection pressure from past infections. Hemoglobin disease variants conferring malaria protection are the (rare) textbook examples of such but are atypical with recent and unusually high selective pressure. By taking advantage of the human population history of Armenia, the excellent preservation conditions of archaeological remains in the region, and remarkably high frequency of FMF disease in the Armenian population, the FeverTime project aims to develop the most comprehensive real time account on the role of evolutionary forces in the local mutation burden. FeverTime will leverage ancient DNA time series data from Armenia within a sophisticated population genomic analytical framework to yield key results regarding the evolution and spread of the disease. The findings will have broad implications for genetic epidemiology, reflecting EU policy priorities

Mots clés : ancient dna, familial mediterranean fever, armenia, selection, genetic drift

Participants :
- Trinity College (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199694.4 €
Projet TOMB (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

TOMB (Tibetan Obsolete Mortuary practices and afterlife Beliefs. Language conservatism of religious writings in the service of Proto-Bodish reconstruction) aims to yield a range of new contributions to our understanding of the Old Tibetan language and funerary practices on the Tibetan Plateau by investigating ancient records concerned with non-Buddhist funerary rituals. In addition, the project will uncover important linguistic links to other regional language communities and will establish the first testable hypotheses about the genetic relationship of Tibetan languages. The synchronic perspective of the philological study will be complemented with historico-linguistic analysis. TOMB will specifically focus on translating documents from the Old Tibetan funerary corpus that have never been translated before. These manuscripts are remarkable for several reasons: 1) they provide insights into funerary rituals that did not survive beyond the Tibetan Empire; 2) they reflect elements of ritual culture shared with other non-Tibetan speaking groups in the region; 3), they offer evidence of earlier, pre-historical stages of the Tibetan language; and 4) they give us an opportunity to enhance our understanding of Tibetan languages and to uncover their genetic links to related languages. Through a comprehensive analysis of the corpus from both historical and text-linguistic perspectives, we will gain insights into archaisms that can be identified as features of pre-historical Tibetan. This foundational work will set the stage for reconstructing Proto-Tibetan. Identifying and describing these features will in turn contribute to the reconstruction of Proto-Bodish, the presumed ancestral language of Tibetan, East-Bodish, and Tamangic languages. The innovative approach to ritual textual sources as reservoirs of pre-historical linguistic forms tackles thus far unexplored fields of research and promises to enrich our understanding of the Tibetan non-Buddhist religious culture.

Mots clés : tibetan languages bodish, sino tibetan , old tibetan, funerary practices, historical linguistics, linguistic phylogeny

Participants :
- Trinity College (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199694.4 €