Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet OBCCMM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

“Ontological Bridge-building for Climate Change Mitigation in Maasailand” (OBCCMM) is a multidisciplinary project that builds bridges across clashing climate ontologies in Maasailand in Tanzania. This holistic project integrates indigenous knowledge and climate science that is negotiated through ecotheological frameworks. The collaboratively developed core values and learning outcomes are worked into curricula components four target research groups. This project leverages existing educational and societal systems of the church with trusted local leaders for educating and equipping with the best practices of climate change mitigation in Maasailand.  This project grows out of recent research that demonstrates a “cognitive dissonance” [clash] between the climate ontologies within the scientific messaging and the traditional Maasai worldview (de Wit, 2020). Thus, the Tanzanian governmental efforts in climate change prevention education are not effective among Maasai, a very traditional people group numbering around two million people in mostly northern Tanzania and southern Kenya, East Africa (de Wit, 2018). However, as a result of the HIV/AIDS pandemic, there is an established basic model of the church providing a strategic role in bridging the cognitive dissonance chasm between the science and a skeptical people group, resulting in effective outcomes (Watt et al., 2009). This project expands the current research; builds upon the previous church-based pedagogy models; integrates indigenous knowledge; collaboratively curates core values and learning outcomes; champions women as the core of the societal structures; and develops innovative pedagogical dissemination with robust analysis of results in order to measure and determine best practices of climate change mitigation in Maasailand.  As the local church made a difference in the health of the people regarding HIV/AIDS, the local church can make a difference in the health of the environment.

Mots clés : climate ontologies, contextual bible interpretation, contextual theology, maasai, climate change mitigation, ecotheology, ecological ethics, indigenous knowledge, tanzania

Participants :
- Tumaini University (Tanzanie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Collège universitaire scientifique diaconal VID (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 242239.2 €
Projet DIASHUTTLE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Colorectal cancer accounted for 12.7% of all new cancer diagnosis and 12.4% of all deaths due to cancer in European Union in 2020. Despite the advances in therapeutics, it is the most recurrent tumors in humans and third common cause of cancer-related deaths worldwide. The current treatment options include chemotherapy, radiation and surgery that are invasive and have side-effects. Also, the 1st and 2nd generation nanocarriers used in cancer therapy consisted of mono-component systems and failed due to lack of targeting molecules, remotely controlled therapeutics window, and patient-specific individualized platforms. The project DIASHUTTLE aims to develop a novel, next-generation, smart, multifunctional and multimodal, hybrid nanotheranostic platform consisting of biosilica extracted from living diatoms for simultaneous diagnosis, treatment, and therapy monitoring of colorectal cancer. It will combine magnetic nanoparticle core, surface deposited metallic gold nanoparticles, tumor targeting biomolecule folic acid, and natural source drug astaxanthin to facilitate different modes of therapy such as magnetically guided or ligand targeted drug delivery, magnetic hyperthermia, and photothermal therapy. It will also concurrently enable different modes of real-time monitoring such as Raman, surface enhanced Raman spectroscopy, magnetic resonance imaging, fluorescence, and photoluminescence. It is expected that the combination of different therapies will exhibit superior synergistic anti-cancer effect over monotherapy and reduce treatment delays by offering a safe and personalized approach to overcome the limitations of conventional cancer treatment. The proposed platform will lead to less toxicity due to the use of targeting molecule and natural materials, controlled drug release, and lower effective drug concentration. Additionally, the nutrient uptake and CO2 sequestration capability of diatoms will support circular bio-economy and self-sustainability.

Mots clés : anti cancer, diatoms, functionalization, drug delivery, biosensing, natural resources, circular bio economy

Participants :
- Conseil national de la recherche (Italie) — Coordinator, beneficiary, Recherche, subvention : 235737.6 €
- Swedish algae factory ab (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet MIGR-AGE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Analysts and institutions estimate that contemporary societies, especially in the Global North, face an entangled triple challenge: the ageing of the population, ensuring the sustainability of welfare state provisions, and migration. Meanwhile, anti-migration discourses have raised, resulting in migrants’ increasing external and internal bordering. In this context, older migrants, and especially economic migrants’ and refugees’ parents and grandparents, are suspected of excessively drawing on social welfare. Consequently, their entrance to and permanence in Global North countries and their access to care benefits and programs are being limited, leading to new forms of stratification in social reproduction. MIGR-AGE aims to understand how the intersection of care, border and labour regimes shapes the strategies of adult migrants to care for and receive care from their elderly parents. The project focuses on the experience of Colombian families in Italy and Canada, in which elderly parents are (or were until recently) living in Colombia. It combines policy analysis with in-depth interviews, participatory videos, and participatory restitution meetings that will be conducted in the country of emigration in the Global South, Colombia, and in the two countries of immigration in the Global North, Italy and Canada. The project adopts an innovative theoretical and methodological approach that crosses disciplines (sociology, anthropology, political economy, and political sciences) and levels of analysis (at the micro, meso, and macro levels). Moreover, it follows a multi-sited and decolonial perspective that does not only focus on Global North countries but crosses analysis in the Global North/South and emigration/immigration countries to better understand migration patterns and inequalities in social reproduction at the global level. By pursuing this objective, MIGR-AGE addresses several Sustainable Development Goals and is in line with the European Care Strategy.

Mots clés : social reproduction, migration, ageing, care, social policies, globalisation, inequalities

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 341683.08 €
- Université Carleton (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université nationale de Colombie (Colombie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet HUMVAR (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

HUMVAR is a project in applied ethics, and it adopts the framework of a particular disability model, the human variation model (HVM). The goal of HUMVAR is to advance research on the HVM, and it has three objectives: first, to provide a philosophical defense of the HVM. HUMVAR’s interpretation of the HVM shows that an important aspect of disability disadvantage is caused by exclusive environments. This causation story grounds societal responsibility and justifies the provision of more accommodating environments —the favored policy response of social models of disability. The first objective defends this interpretation against the challenge that social models of disability cannot justify the policy of environmental reconstruction. HUMVAR’s second objective is to redefine the problem of disability that the model articulates as a special case of discrimination (discrimination-as-human-variation). Discrimination-as-human-variation is a revisionary account of the HVM, as the original version of the model aims to be an alternative to discrimination-based approaches to disability. This revisionary interpretation explores that disability-as-human-variation is a form of ableism. The third objective is to expand the idea of human variation to the case of linguistic diversity and justice, showing that the logic of the HVM is present in other spheres of social life beyond disability. HUMVAR makes the case that minority languages are also disadvantaged by their social environment and vulnerable to discrimination-as-human-variation. It also examines the case of sign language through the lens of linguistic justice to find a novel answer to why changing individual impairments is problematic from a moral point of view. HUMVAR's answer is that society’s insistence on changing individual impairments instead of providing accommodating environments is a case of wrongful assimilation.

Mots clés : disability non discrimination linguistic justice accommodation social inclusion

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
- KU Leuven (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SIGMA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

When speakers syllabify a word, they are expected to rely on their implicit knowledge of how their phonological grammar treats certain sound sequences; yet, they often produce or accept as well-formed alternatives that may come into conflict with grammar rules. Interestingly, such “divergent” variants seem to be influenced by prescriptive hyphenation rules.  SIGMA examines the influence of hyphenation on the perception and production of syllable boundaries taking Standard Modern Greek as a case study. The speakers’ varying preferences will be revealed via large-scale experimental tasks addressing participants of diverse literacy backgrounds and employing novel methodologies (language games, judgments using a Likert scale) for the first time in research on Greek syllabification. Intra- and cross-speaker variation will be modeled within Gradient Harmonic Grammar, which assumes that abstract representations ‒here, innovatively, structural components of the syllable‒ have a gradient activity level that affects their probability of realization. Thus, instead of selecting the “correct” form and discarding all others, this model generates variants with different chances to emerge. The findings will be incorporated into a concise guide offering an up-to-date description of syllabification rules, introducing variation as a possibility.  SIGMA’s experimental methodology and theoretical assumptions can be extended to the study of a wide range of linguistic phenomena and populations, including individuals with speech pathologies or speakers of L2/heritage Greek. Beyond its significant scientific impact, its applications, especially to education, will have major societal and economic impact, as the project paves the way for revising educational resources, including tailored materials for atypical/non-native populations. These enhanced materials will be exploitable by official educational bodies in Greece and abroad, in curricula for Greeks of diaspora or language learning apps.

Mots clés : phonology orthography interface, syllabification, hyphenation rules, greek syllable structure, production experiments, perception experiments, phonological variation, gradient harmonic grammar

Participants :
- Université de Tromsø (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 210911.04 €
- Université de Crète (Grèce) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet LISTAF (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The LISTAF project seeks to develop biodegradable photonic materials using starch and lignin as sustainable alternatives to conventional, non-biodegradable colorants in the food industry. These materials harness photonic color, which offers greater durability compared to pigment-based colors and finds applications across industries. The project centers on three key work packages:  1. Precision production of starch nanoparticles (SNPs) through enzyme-assisted techniques, with a focus on controlling amylopectin branching and optimizing self-assembly conditions.  2. Utilization of lignosulfonates and colloidal lignin as surfactants to stabilize SNPs, exploring variables such as concentration, pH, and addition timing to control SNP size and polydispersity.  3. Development of photonic starch and coatings for food industry applications, including in vitro digestion and fermentation analyses to assess nutritional advantages.  Outstanding challenges to address include overcoming SNP aggregation, gaining control over nanoscale starch-lignin interactions, and achieving close-packed assembly of the particles. The project aims to address these challenges through enzyme-aided research and innovative bio-based surfactant systems. Ultimately, the goal is to create eco-friendly, cost-effective, and nutritionally valuable materials that align with consumer demand for high-quality food products. The successful completion of this project will provide me with valuable training in lignin chemistry and bio-photonics, while also enabling me to conduct groundbreaking research in the field of starch applications. This comprehensive experience will expand my research expertise, yield high-quality publications, and significantly enhance my prospects for securing a faculty position in the future.

Mots clés : starch lignin food nutrition structural color photonic crystal glass

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
Projet Spatial miRNomics (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Glioblastoma is the most common and aggressive brain tumour, with an 85% mortality rate within two years of diagnosis. In Europe, tens of thousands of people die from glioblastoma every year, and currently there are no effective treatments. Glioblastoma tumours exhibit high genetic and phenotypic heterogeneity with numerous cancer subclones. This complexity complicates the identification of useful clinical features across patients, highlighting the importance of studying glioblastoma from the perspective of its heterogeneity. MicroRNAs are small, non-coding RNA molecules that regulate gene expression post-transcriptionally. They play an important role in glioblastoma, where their dysregulation can drive tumour development. In addition, microRNAs hold potential as biomarkers, with the unique duality of acting both as targetable molecules and deliverable drugs, offering new opportunities for diagnosis and treatment. However, to date, no imaging method has achieved multiplexed mapping of microRNAs in tissues, resulting in a gap in understanding their spatial distribution within key tumour regions and how they contribute to glioblastoma heterogeneity.  Spatial miRNomics is a pioneering concept that will, for the first time, map the spatial distribution of microRNAs in single cells and across glioblastoma tissues. Funded by the Marie Skłodowska-Curie Actions, Spatial miRNomics will extend spatial biology to microRNAs to close that gap, revealing their landscape in brain tissues, and their clinical significance in glioblastoma. This multidisciplinary effort will be performed at Mats Nilsson's Group (Stockholms Universitet), pioneers in spatial biology, and conducted at SciLifeLab, in the Karolinska Science Park. SciLifeLab excels in spatial omics with strong research, clinical and industrial collaborations and exceptional infrastructures. Aligned with the European Cancer Mission, Spatial miRNomics aims to strengthen European leadership in health innovation.

Mots clés : micrornas spatial biology spatial transcriptomics in situ sequencing gene regulation brain cancer glioblastoma

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252180.0 €
Projet ACUTE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The Arctic Ocean is a hotspot of methane, which is a powerful greenhouse gas stored in the form of gas hydrates, subsea permafrost, and underlying thermogenic gas. The sizes of these methane deposits are poorly constrained, but even the release of a small fraction could have significant effects on the global climate. The uncertainty is in part linked to microbial processes and especially little is known about aerobic methane oxidation of methane-oxidizing bacteria.  The research project’s overarching objective is to investigate the relevance of aerobic methane oxidation for the Arctic by combining biogeochemical parameters with genomic data. The project has three scientific work packages. The first work package will characterize the benthic microbial community, specifically methane-oxidizing bacteria, and link it to methane cycling in the porewater and biomarkers of Siberian Arctic sediments. The second work package investigates the carbon cycling and methane oxidation of methane-oxidizing bacteria in the water column of the Siberian Arctic Ocean. The third work package has an experimental approach to simulate methane release from subsea permafrost and seeps as future tipping point ecosystems.  ACUTE is an interdisciplinary project that will significantly advance our understanding of aerobic methane oxidation. This work relies on unique and valuable archived data, which minimizes the environmental impact of my research activities, conforming with the MSCA Green Charter, and significantly contributes to the few studies linking biogeochemistry and microbial communities across the Arctic Ocean. The excellent research facilities and work environment at Stockholm University promote a two-way transfer of knowledge. The generated results will be available through open science practices and of interest beyond the scientific community to policymakers and citizens, especially with rising awareness during the ongoing UN Ocean Decade.

Mots clés : climate change, arctic, permafrost, methane, bacteria

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189135.0 €
Projet LIGNIRON (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Recent advances in lignin nanotechnology have opened up new possibilities not just for underutilized lignin side streams but also for hybrid organic-inorganic nanocomposites. One specific instance is mixing metal ions with lignin nanoparticles (LNPs) to create new materials with desired superparamagnetic properties. Currently, limited knowledge exists regarding the interaction between LNPs and iron, which is what LIGNIRON intends to fill. Additionally, there is no indication of how iron oxide nanoparticles can be encapsulated into LNPs in a reproducible and uniform manner. Identifying these gaps and unlocking the full potential of the lignin-iron complex requires developing fundamental knowledge of the lignin-iron surface chemistry using microfluidic systems where a variety of opportunities exist for studying hybrid material formation. The combination of this knowledge with electrospinning processes would result in a new method that may translate academic research into practical application for continuous mass production of lignin-iron hybrid materials. By achieving these objectives, LIGNIRION paves the way for the application of LNPs into innovative functional materials and creates a new high-volume, high-value end-use for lignin, thereby contributing to the implementation of the EU circular economy policy. Ultimately, the new materials are designed to be used as as retrievable flocculants to remove nano-plastic from water, enabling EU water treatment plants to be effectively prepared for future combat against nano-plastics without significant infrastructure expansion costs.

Mots clés : lignin circular economy nano plastic removal inorganic organic hybrid material

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet NanoTrojans (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : TERMINATED

Nanoplastics (nPLs), defined as organic polymeric particles ranging in size from 1–1000 nm, represent emerging contaminants that are of significant relevance to environmental and food science, especially since initial toxicological studies have shown them to cross the gut barrier with unpredictable long-term effects. Such early-stage research signifies the need to study nPL behavior in greater detail, both in terms of their physicochemical behavior in the environment, as well as their toxicity. The latter may also be affected by their potential to (ad)sorb and transport other chemicals, especially toxic metals and organic pollutants, into living systems. Compared to microplastics (μPLs) ranging in size from 1-5 mm, nPLs possess significantly larger surface-to-volume ratios, thus making this effect more pronounced. As a result, such a Trojan horse-like transport of toxic chemicals into cells urgently needs further study and improved understanding. Therefore the main research and innovation objective of this project is the development, validation and application of novel analytical methods that aim to overcome current shortcomings in the detection and quantitation of nPLs, in environmental, food and biological systems. The analytical methods proposed in this project (hydrodynamic chromatography on-line with inductively coupled plasma mass spectrometry along with appropriate sample preparation procedures) aim to provide capabilities that can be used to determine nPL particle size and the polymer or carbon amount per size fraction. These two parameters can be used to indirectly estimate nPL particle number concentrations, providing the plastic’s density is known. The proposed methods will also be used to monitor the presence of metals or metalloids either as additives or adsorbed onto nPL surfaces.

Mots clés : nanoplastic determination, inductively coupled plasma mass spectrometry, hydrodynamic chromatography, ion mobility spectrometry, electropsray mass spectrometry

Participants :
- Hellenic Centre for Marine Research (Grèce) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Crète (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 169326.72 €