Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet TextrodeMisc (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Textile-based electrodes are about to be competitive alternatives to traditional electrodes for ECG and EMG. Electrodes integrated into textiles are easier to use which facilitates home-based monitoring, treatment and rehabilitation measures. One potential key application is Phantom Limb Pain (PLP) treatment using Phantom Motor Execution (PME), where EMG signal from the remaining muscles of the amputated limb is used to control a Virtual Reality (VR) representation of the lost limb. However, textile electrodes still need to be improved regarding electrode contact and adhesion to the skin. This calls for new sensing materials that may not have textile properties and thus need to be integrated into the textile in new ways. So, the aim of this project is to a) try new sensing materials that will improve the electrode contact and adhesion to the skin, and b) find ways to solve the interfacial linkage between the sensing material and the textile substrate. The project will focus on novel materials and textile construction development to overcome these issues. The main project deliverable is generic textile matrixes of electrodes that can be competitive alternatives to traditional electrodes. This should contribute to making e.g. PLP treatment generally available and easy to use as improved electrode signal quality would lead to better treatment effect, durability and sustainability. The concept of controlling the lost limb (central to the PLP treatment based on PME) is directly transferable to myoelectric controlled prostheses. Thus, we also aim to test what the new type of electrode matrixes could contribute to this “twin” application. The applicant's expert knowledge in sensing materials can together with smart textile experts (University of Borås), biomechatronic and pain researchers, and clinical connections (Chalmers Industriteknik) and users with limb differences make a breakthrough that addresses issues of high technical and social relevance.

Mots clés : myoelectric signals, textile electrode, phantom limb pain, smart textile, skin electrode impedance, interfacial engineering, myoelectric controlled prosthesis, self administered

Participants :
- CIT Energy Management (Sweden) (Suède) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Borås (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet NEO-IDENTITY (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

NEO-IDENTITY investigates the social dynamics behind the formation of regional identities in the Fertile Crescent, at one of the turning point of human history when the fundamental economic, social and ideological changes constituting the Neolithic occurred in the beginning of Holocene. The project is designed to examine ways of doing in the domain of subsistence (1), symbolic context (2), and regional connectivity (3), by studying lithics and models of socio-cultural interactions. This research will greatly enrich our understanding of the transition to sedentism and emergence of agriculture by exploring the technical traditions and cultural affinities of Pre-Pottery Neolithic (PPN) groups in Upper Mesopotamia. NEO-IDENTITY studies the evidence from PPNA and PPNB (10.000-7500 BC) archaeological sites in SE Turkey, which exhibit distinct settlement organization, characterized by communal spaces that have been described as the earliest monumental architecture in Southwest Asia. The main aim of the project is to establish a research framework based on the recognition of material expressions forming cultural identities, while challenging traditional conceptual views. NEO-IDENTITY employs a novel integrated scientific outline resulting in merging method and theory. Project will use the methodological approach which combines advanced lithic technological, use-wear analyses and cutting-edge quantitative analyses through the study of micro-wear texture by Confocal Scanning Microscopy, with the analytical techniques and models for examining spatio-temporal distribution of technical traits, interaction and transmission of skills and innovations.

Mots clés : prehistory, neolithic, sw asia, anatolia, lithics, flint, obsidian, use wear analyses, interactions, technology, identity, socio economic changes, symbolism

Participants :
- University College de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet UPWIND (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Clean energy production needs to expand in order for Europe to achieve its net-zero emission goals of 2050. UPWIND aims at the “massive” and “rapid” upscaling of the current onshore wind turbine stock in order to address the highly challenging sustainable energy targets and mitigate climate crisis. 38GW of existing onshore wind structures will reach their end-of-life in Europe by 2025 and new wind farms typically take about 13 years from concept to operation. Upscaling existing structures is the only reliable strategy to immediately increase wind energy installations as it can double generation capacity (in MW) of existing onshore wind farms within a very short period.  UPWIND aims to develop an innovative machine learning-assisted upscaling framework for existing onshore wind structures to be converted to new-age powerful ones. This will be achieved by replacing old turbines with more efficient and powerful new-age turbines, increasing the height of the existing onshore tubular steel wind turbine towers, enhancing the load-bearing capacity of the towers and by extending their operational life. The research output of UPWIND will enable decision-making for innovative repowering strategies focusing on upscaling the existing support towers to bear the new loads (increased self-weight, fatigue vibrations) caused by heightening and new turbines installation, by selecting suitable strengthening schemes. New upscaling methods and strengthening schemes will be implemented and a new digitalized decision-making framework for repowering old wind turbine towers will be developed.  UPWIND will introduce a gamechanger strategy that will directly increase energy production from wind structures, taking advantage of the already used best onshore locations and existing permissions, avoiding non-economic and non-environmental friendly total tower replacements, thus significantly contributing to a fully circular net-zero future for the european energy sector.

Mots clés : steel structures, structural engineering, civil engineering, wind energy structures, wind turbine tower design, sustainable design, sustainable energy production, economical design, net zero economy

Participants :
- Université de la Ruhr à Bochum (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Aristote de Thessalonique (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181423.68 €
Projet BPYMAC (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

In the quest for a sustainable and eco-friendly future, enzymatic catalysis has emerged as a pivotal platform, steering chemical synthesis towards environmentally benign pathways. The use of natural cofactors such as NADH (nicotinamide adenine dinucleotide, reduced) and NADPH (nicotinamide adenine dinucleotide phosphate, reduced) has been instrumental in these processes, providing essential reducing equivalents for numerous enzymatic transformations. In the production of valuable chemicals and pharmaceuticals via biocatalysis, NAD(P)H is utilized by various enzymes.NAD(P)H-dependent processes play a key role in pharmaceutical industry and the environment (reducing CO2 emissions), in the production of valuable fuels and chiral active pharmaceutical ingredients (APIs).While NAD(P)H is effective as a cofactor, it presents several issues that limit its practicality and sustainability – mainly due to high cost of cofactor, high process costs due to lack of recyclability and complex downstream processing. The central idea of BPYMAC is to leverage the advantages of bipyridines as ideal mediating artificial cofactors (MACs) to replace NAD(P)H due to their synthetic versatility, recyclability, tunability and stability. Synthetic strategies enable their conversion to redox polymer enabling their application as polymer films on electrodes, allowing their use in reactors with facile product separation. This will be the end goal of BPYMAC, meeting significant gaps in the state of the art. BPYMAC's research outcomes will help revolutionise bioelectrocatalyis by targeting synthesis of valuable products from CO2 reduction and production of chiral APIs in a reactor consisting of polymeric MAC and enzyme, optimised to produce products in high yield and with high stereoselectivity. These reactions will provide proof-of-concept for the potential of BPYMAC's tailored MACs as NAD(P)H replacements for reactions of interest for industry, society and the scientific community.

Mots clés : nad p h replacements, enzyme catalysed reactions, bioelectrocatalysis, co2 reduction, chiral api synthesis

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet MetaChange (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

MetaChange is an original and innovative project combining large scale online psychophysics experiments, invasive electrophysiological recordings in epileptic patients and computational modeling in order to brush a comprehensive picture of the effect of post-decisional information on the cognitive and metacognitive components of decision making. The project will use a causal approach based on stimulus manipulation or direct brain stimulation to explore the effects of post-decisional information on these components of decision making, and assess how these effects unfold in time. We also aim at determining the neuronal mechanisms supporting decisional and post-decisional integration, as well as their link with metacognitive processes such as confidence ratings and changes of mind. Finally, we intend to develop a computational model of decision making rooted in evidence accumulation, accounting not only for response times and response accuracy but also for changes of mind and confidence ratings. Overall, MetaChange aims to address in an interdisciplinary and synthetic manner some of the current challenges in the field of decision making and metacognition.

Mots clés : decision making, metacognition, evidence accumulation, epilepsy, invasive recordings, electrical stimulations

Participants :
- Université Humboldt de Berlin (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Masaryk (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166278.72 €
Projet GRANITE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

In EU-27, it is estimated that >355,000 were diagnosed with breast cancer (BC) in 2020. Initiatives to reduce this burden in Europe involve early and precise diagnosis in the standard-of-care management to decrease unnecessary or insufficient treatment. Notably, precision medicine in BC is still in its infancy and is becoming even more critical with neoadjuvant chemotherapy (NAC), a standard of care treatment protocol in HER2-positive and triple negative subtypes. Recently, the use of digital diagnostics with AI is gaining momentum since it shows great promise towards accelerating personalized BC patients’ pre- and post-NAC predictions. While AI paves the way to next generation diagnostics, this has yet from been translated as a) it mostly operates in single data modalities that fail to capture the complex disease alterations, b) integrated AI usually suffers from data incompleteness usually leading to models trained with limited data that fail to generalize to new patients and/or that are not able to integrate partially observed multimodal information from the whole population. GRANITE focuses to address these unmet needs and goes beyond the state-of-the-art, fusing the most relevant standard of care data (radiology, pathology, clinical, demographic), leveraging novel AI and radiomics algorithms. GRANITE will deploy pre-trained deep learning models that will be fine-tuned, technically validated and clinically evaluated against pertinent clinical data of non-metastatic BC cases from the Bank of Cyprus Oncology Centre, Cyprus. We will engage with the AI4HI project to transcend FUTURE-AI guidelines (Fairness, Universality, Traceability, Usability, Robustness and Explainability; future-ai.eu) into GRANITE towards generating real-world evidence and making our AI technology clinically sound, ethically aware and technically applicable, and promoting AI trust and acceptance in BC management.

Mots clés : integrated ai deep learning radiomics breast cancer neoadjuvant medical imaging

Participants :
- AstraZeneca (Sweden) (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut national de recherche en sciences et technologies du numérique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Chypre (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 164328.0 €
Projet NETRePerform (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Discussions on the relation between gender-forming discursive practices and biological reality inevitably turn to the body where nature and culture intersect. Is the body a mere “canvas” for symbolic practices to inscribe divisions and exclusions or does biological reality dictate divisions and limitations to symbolic practices? Both symbolic practices and biology rely on a temporal dimension that shapes the discussion: Is a historical or a discursive time able to effectuate these radical inscriptions or does biological time generate these practices? Our project will address this issue by synthesizing multiple perspectives. First, we will sketch an innovative framework for addressing embodied temporality by tackling from a phenomenological perspective the complex relation between time, body, and motivation. Our programmatic emphasis on motivation's relation to embodiment will initiate a series of innovative shifts. We will proceed to the dimension of language at the level of narrative. Dismissing recent naturalistic approaches, we will instead revisit Ricoeur’s work searching for a novel perspective that will allow us to reinstate the pertinence of narrativity. We will then address Butler's conception of gender-performativity by first carrying out an investigation of speech-acts and their temporal structure. Ricoeur’s and Butler’s respective critical accounts of speech-acts will serve as our guide. We will claim that non-discursive elements of speech-acts determine their temporal structure and we will thematize their bodily origin. Exploring the bodily involvement of motivation will form a novel framework that will allow our investigation of the embodied nature/culture intersection to move beyond the models of naturalization and performativity. We will be discussing with feminist and gender theorists who have variously thematized the problem of biological materiality.

Mots clés : narrative, embodiment, temporality, performativity, phenomenology, hermeneutics

Participants :
- Université de Chypre (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 164328.0 €
Projet SMECOCOAT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The world is moving towards sustainable economic growth and green technologies; therefore, the high specific strength, easy recyclability and lightweight of Magnesium (Mg) based materials make them potential options to minimize weight, save energy and reduce environmental issues. However, their poor corrosion resistance in aqueous and atmospheric conditions limits their widespread usage in many industrial applications. Enormous effort has been made to protect Mg and its alloys against degradation and improve their service time. Despite that, the questions related to their durability, longevity, biocompatibility, cost and environmental impacts must be resolved. This scientific work aims to develop durable, multifunctional multilayer composite (MMC) coatings to provide long-term corrosion protection to Mg-based materials. Durability and long-term protection will be achieved by using eco-friendly materials and considering interfacial adhesion strength between substrate/composite within the multilayers and their surrounding environments. MMC coatings will be prepared to protect Mg-based materials against corrosion and give a visual response when the coating is damaged to achieve this scientific goal. MMC coating will consist of a self-assembled organic layer, a polymeric composite containing corrosion inhibitor and sensing agents loaded metal-organic frameworks (MOF) using a stimuli-responsive polymeric gatekeeper in a single layer and a top self-cleaning hydrophobic polymeric layer. They will provide adequate long-term corrosion protection of Mg-based structures by the synergistic effect of self-cleaning, passive barrier layers and on-demand release of active corrosion inhibitors from loaded MOF. Corrosion-sensing agents encapsulated MOF will monitor the onset of corrosion upon physical damage to the coatings for large area systems. MMC coatings will ensure minimum cost and environmental impacts consistent with desired properties and help to substitute PFAS.

Mots clés : corrosion, surface modification, coating and films, organic inorganic hybrid materials, intelligent and self assembled materials

Participants :
- Helmholtz-Zentrum Hereon (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet BoFTISync (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

We are currently witnessing a technological revolution driven by the recent achievements in NISQ devices, which despite their imperfect controllability have already revolutionized our understanding of many-body dynamics and quantum information science. While a lot of effort is spent to minimize the undesirable consequences of dissipation, interactions with the environment can also generate useful quantum behavior. The phenomenon of synchronization is a prototypical example where dissipation is a key enabling mechanism and it only recently started to emerge in the quantum domain due to advancements in quantum technology to exquisitely adjust both the system and environmental properties. Still, inevitable imperfections -- local deformations caused by ambient conditions and long-term degradation -- may significantly alter or even destroy the desired synchronicity altogether, which ultimately constraints its pertinence for future quantum devices. Consequently, we are in the need of universal principles to promote the robustness of synchronization and facilitate its technological leap. The proposed project 'BoFTISync' addresses this task by exploiting the power of topological phases of matter, which exhibit an unusual protection from the adverse effects of impurities. With a unique interdisciplinary approach of integrating topological concepts with dynamical symmetries of interacting bosonic modes and open quantum systems, the project aims to establish topology as an innovative way to protect quantum signatures of synchronization, and at the same time opens the avenue for unexplored phenomena at the interface of these seemingly distinct research areas. This investigation is not only fundamentally interesting, but will also spark new applications in quantum technologies and information processing in NISQ platforms ranging from trapped ions to optomechanics. Thus, BoFTISync will prepare the ground for a deeper understanding on topology in open nonlinear systems.

Mots clés : open quantum systems, synchronization, topological insulators, many body physics, nonequilibrium

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet DrosoParamutation (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Understanding how organisms rapidly adapt to changing environments is a fundamental question in evolutionary biology. Transgenerational epigenetic inheritance (TEI) has been proposed as a mechanism that allows organisms to respond flexibly to environmental variation and thus plays a central role in rapid adaptation to fluctuating environments. A compelling example of this process is paramutation, in which epigenetic information is transferred from one allele to another, leading to heritable changes in gene expression across generations. However, our understanding of paramutation in natural animal populations remains limited, with most evidence coming from laboratory models. This knowledge gap hinders our understanding of the role of paramutation in nature.  Here, we will study paramutation in different natural populations of Drosophila melanogaster to investigate its potential to drive transgenerational epigenetic inheritance and gene expression variation that can shape evolution. We will investigate the responsiveness of paramutation to environmental changes and its heritable stability across generations. We will also establish a model to dissect the molecular mechanisms of paramutation regulation, assessing the role of insulator proteins such as Su(Hw) and 3D chromatin conformation. This project will provide a comprehensive investigation of the role of paramutation in natural animal populations at multiple levels of information, including genetics, epigenetics, gene expression, and 3D chromatin structure.  This research proposal aims not only to determine the biological relevance of a case of transgenerational epigenetic inheritance such as paramutation in natural animal populations but more importantly to provide an excellent model system for its in-depth molecular dissection.

Mots clés : drosophila melanogaster, transgenerational epigenetic inheritance, paramutation, natural populations, environmental change, adaptation

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €