Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet APOCOLIPS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : TERMINATED

APOCOLIPS aims to develop advanced functional polymer colloids with high photo-oxidative properties. Two promising applications have been envisaged for these materials: 1) to develop efficient self-disinfecting and antimicrobial resistant polymer films and 2) to design stable colloidal dispersions for photo-oxygenation of organic molecules for fine chemicals production. One of the most innovative aspects of the proposed research is that it targets the preparation of advanced polymer coatings integrating organic photosensitizer (PS) via covalent bonding by implementing a straightforward, industrially viable and safe process. Another innovation of APOCOLIPS is to combine the key advantages of flow photochemistry with the ones of supported PS to develop stable submicronic photo-active polymer colloids which can be easily transported by the continuous phase in the microfluidic devices, while being recycling. The final goal of the two-year fellowship is to advance and diversify the competences of Dr. Aboudzadeh both as a researcher and as a future leader in the field of polymer materials for a sustainable world. APOCOLIPS is highly multidisciplinary combining polymer chemistry, polymer physics, photochemistry, microbiology, chemical engineering and green chemistry. The fellowship will bring together the knowledge of Dr. Aboudzadeh, who recently obtained his PhD degree in polymer materials from Spain, with those of Dr. Save (project supervisor) in polymer chemistry and the skills of Dr. Lacombe in photochemistry. Moreover, the project benefits from a national collaboration with Dr. Loubière from LGC (Toulouse) with strong experiences in continuous flow photochemistry. The host centre is CNRS that boasts outstanding facilities and excellent contacts with industry. Finally APOCOLIPS brings about the fellow a three-month international and interdiciplinary secondment (Ulster University, UK) under supervision of Prof. Fernandez-Ibañez, an expert in disinfection technologies.

Mots clés : polymer colloids, singlet oxygen, photosensitizer, antimicrobial resistance, continuous flow, technologies, self disinfecting

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 196707.84 €
Projet APPFlow (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks - Industrial Doctorates
Panel : Chemistry
Statut du projet : SIGNED

APPFlow will develop Early Stage Researchers (ESRs) in innovative research through a focussed training plan centred on flow chemistry, essential for the pharmaceutical and fine chemical industries in Europe. The training programme and research proposed in APPFlow tackles the problems associated with the production of advanced intermediates en-route to Active Pharmaceutical Ingredients (APIs) in the pharma-industry. The proposal is aligned with important European research goals outlined in Horizon 2020. Specifically, this research will address areas related to Resource Efficiency, Health, Environment and Nanotechnology. The end goals align with those of the SPIRE 2030 targets and aims, most closely aligned with the goal of ‘a reduction of up to 20% in non-renewable, primary raw material intensity compared to current levels by 2030.’ It comprises of three training sites located in Ireland (1) and the UK (2) and involves multidisciplinary collaboration between academic and industrial partners, each with complementary expertise across a range of disciplines. The programme will train 3 ESRs who will gain state-of-the-art, transferable knowledge in a number of valuable areas such as organic chemistry, catalytic chemistry, chemical engineering, process design and economics. APPFlow will establish long-term collaborations and develop structured research and training relevant to industry and academia and result in highly trained and employable ESRs. At the end of the APPFlow programme, the ESRs will possess a multidimensional perspective to research, enabling them to address problems with a holistic approach. The ESRs will also develop a range of transferable “soft” managerial skills that will widen their potential career opportunities and ability to contribute to a range of different sectors. For example, they will receive business and entrepreneurship mentoring, which will assist them in becoming future business leaders.

Mots clés : flow chemistry, oxidation catalysis, hydrogenation, reactive intermediates, green chemistry

Participants :
- Queen's University Belfast (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 909517.68 €
- Almac (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Arran chemical company limited (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
Projet ATRA (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

ATRA - Atlas of Renaissance Antiquarianism is a digital system that will map the circulation of antiquarian learning in sixteenth-century Europe. Its purpose is to contribute to the promotion of new knowledge on antiquarian studies in the Renaissance and demonstrate how the antiquarian approach – that based the growth of thought on documented sources and empirical evidence – played a primary role in the evolution of the entire cultural/intellectual life of Early Modern times. The main intent is to allow the interconnection of data that otherwise would probably never come into contact and to bring to the surface issues not yet bridled in rigid classifications. This will enable the discovery of new cultural itineraries and convergences in Renaissance scholarship; trace the paths that led to parallel or independent ideas; and uncover new trends of thought that can help us better understand the evolution of European civilization and spirit. Innovative and revolutionary interpretative pathways will come to light, conferring a renewed awareness of the concept of Renaissance antiquarianism and offering to the entire academic community further instruments to investigate the History of Ideas. This project is essential for Acciarino’s personal career growth and for the global development of this field of study. Thanks to this training and to his entire course of studies that has allowed him to grow as a researcher and as an academic scholar at a European level, he will also be able to cooperate with cutting-edge institutions of excellence for multidisciplinary research in Renaissance studies and develop competencies in digital humanities that will render his professional profile technologically up-to-date and more competitive. Through the Renaissance network created between UNIVE and University of Toronto, dialogue, research and innovation will gradually grow and become a guiding light for the entire academic community.

Mots clés : antiquarianism, intellectual history, humanism, renaissance, circulation of culture, european spirit

Participants :
- University of Toronto (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 229761.0 €
Projet InvADeRS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Aberrant epigenetic regulation of placental function is implicated in several complications of pregnancy, such as preeclampsia, recurrent pregnancy loss and fetal growth restriction. Notably, the placenta has a unique epigenetic landscape, permissive for the activity of transposable element (TE) derived DNA sequences. TEs are often co-opted by the host genome as cis-regulatory elements, driving tissue- and species-specific gene expression programs. Indeed, TEs contribute many placental-specific enhancers in mouse trophoblast. However, the presence and role of a similar TE-derived regulatory network has not been explored in human trophoblast. As TEs are highly species-specific, such a network in humans would be expected to regulate species-specific placental characteristics, such as the deep interstitial invasion unique to great apes. TE-derived regulatory elements may therefore be important for placental homeostasis and be involved in diseases characterised by aberrant placental invasion. I propose to map TE-derived cis-regulatory sequences in human trophoblast ex vivo using their histone modification signatures. I will assess the regulatory potential of candidate TEs through transcriptomic analyses and motif analysis to reveal transcription factor binding sites, highlighting promising candidates of importance in the human placenta. I will then directly test the function of top TE candidates using CRISPR-Cas9 genome editing of the TEs in trophoblast in vitro, and measuring changes in expression of target genes. Finally, I will elucidate epigenetic and coding differences between complicated and normal control placentas at the functional regulatory TE loci I find, to identify correlations with disease. This project will provide a comprehensive analysis of an as-yet unexplored aspect of human placental epigenetic regulation, and potentially identify novel causes of common unexplained complications of human pregnancy.

Mots clés : transposable elements, human placenta

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet BULLE (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

About 98% of the ocean’s biomass is composed of microorganisms like the tiny algae, phytoplankton. Tiny but mighty when it comes at capturing carbon dioxide (CO2). Phytoplankton acts for half of the Earth’s photosynthesis, allowing ocean’s to supply major living resources and dioxygen (O2). Microbial respiration is the other fundamental biological process that counterbalances photosynthesis and returns organic carbon back as CO2. Yet, despite ocean’s pivotal role in global climate, microbial respiration remains one of the least explored metabolic processes; so that, whether oligotrophic ocean is a net sink or source of CO2, is highly debated for the last 20 years. The BULLE project aims to evaluate the ocean’s metabolic balance between photosynthesis and respiration by looking at the production of CO2 evolved to that O2 consumed by marine bacteria, the so-called “respiratory quotient” (RQ). Limits of detection of biological CO2 production have left RQ measurements far behind the multitude of investigations of photosynthesis. BULLE will face these challenges using the most recent technologies. The project strongly relies on the multidisciplinary expertise I will share with my host lab to tackle this issue at both cellular and community level. Specifically, BULLE aims to (1) investigate how the chemical characteristics of nutrients (Fe and C) regulate the RQ in bacterial cells and (2) study the links between the RQ, net primary production and bacterial activities. An innovative aspect of BULLE is the implementation of continuous measurements of O2/N2 and pCO2 concentrations respiration, and the deployment of In Situ Oxygen Dynamic Autosampler (IODA) instrumentation in the coastal NW Mediterranean Sea. The training I will receive with BULLE will help me give my career a new direction from a lab expertise towards high resolution in situ observations. In return, I will transfer my experience in microbial metabolisms and radioisotopes tracking methods to the host team.

Mots clés : respiratory quotient, microbial respiration, carbon cycle, biological co2 and o2 fluxes

Participants :
- Aix-Marseille Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €
Projet ENGECON (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Abstract: ENGECON will study by a transnational-comparative prosopographical approach the engagement of economists in the communist, socialist and labour lefts over three Western European major countries (France, United Kingdom and Italy), from the 1930s to the 1960s. By engagement, ENGECON means a partisan activism linked to the participation in public debate that contributes to the legitimization, dissemination as well as the elaboration of economic ideas. It studies three principal specific objectives: the factors explaining engagement; the practices of engagement; the implications of engagement for the economic thought, as well as the professional trajectory and the intellectual status of the engaged economists. It assumes that the analysis of engagement is essential to understand the role of economists in society. An unprecedented role of economists in a labour movement on the ascent, the rise of the heterodox economics and the apogee of the managed economy characterise this period. Host organisation: Faculty of History, University of Cambridge.

Mots clés : economists, engagement, intellectuals, economics, political parties, militant trajectories, networks

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet DYNAMICE (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Accelerated arterial stiffening, an important complication in diabetes, increases cardiac workload eventually leading to heart failure. The arterial wall —consisting of elastin, collagen, smooth muscle, and glycosaminoglycans— may stiffen in diabetes due to 1) advanced glycation end-product (AGE)-induced collagen cross-linking, 2) calcification, or 3) changed glycosaminoglycan composition. The exact mechanical stiffening effects of these processes are unknown. Current preclinical, state-of-the-art measurement methods characterise arterial wall mechanics under static conditions. However, AGE-induced and glycosaminoglycan-associated wall stiffening may particularly affect dynamic characteristics (viscoelasticity) — especially relevant in vivo where arteries are subject to pulsatile blood pressure. The novel set-up for mechanical characterisation under such dynamic conditions I have previously developed still requires a matching computer modelling framework to correctly interpret the multidimensional, dynamic measurement data. I aim to 1) develop this modelling framework and 2) use it to quantify the characteristics of diabetes-associated stiffening processes by studying murine arteries with increased calcification, collagen cross-linking, glycosaminoglycan content, and combinations thereof. The forthcoming measurement platform —already sparking interest among international collaborators— enables realistic preclinical biomechanical arterial characterisation and will be the integrative keystone in my multidisciplinary research career. Its application to diabetes-associated arterial stiffening may yield breakthrough target and focus to further treatment of patients. Furthermore, its accessibility to (inter)national collaborators will be ensured by its implementation at the independent Special Skills & Advanced Phenotyping unit at the Maastricht University Biomedical Center — a dedicated core laboratory for phenotyping of small animal models.

Mots clés : blood vessel mechanics, structure function interaction, constitutive computer modelling, tissue structure, arterial stiffness, hypertension, vascular complications of diabetes, large arteries

Participants :
- Maastricht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260929.8 €
- Yale University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet LINKIP (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Access to clean drinking water is a necessary basis of life. A trend towards more use of groundwater is expected due to problems of securing safe drinking water from surface water. To overcome the future problems in groundwater management and protection a new geophysical research approach will be developed. The main objective of this project is to assess how enhanced spectral resolution in DCIP (direct current induced polarization) data can be used to better characterize the subsurface with the newest optimized data acquisition hardware in combination with the latest developments in data processing algorithms. The link information related to hydraulic properties and pollution status properties to geoelectrical models of the subsurface can be achieved by answering the four big questions which each culminate into a separate work package: 1) Can sufficient spectral information be expected from time domain IP data? 2) To which extent can spectral information be acquired with time domain IP? 3) What can be achieved with the new DCIP processing and inversion algorithms? 4) Can hydraulic properties be estimated from spectral time domain IP data? The questions will be answered by the comparison of both methods in lab and under field conditions and the analyses of the data by the newest (enhanced) algorithm. The link between the time domain spectral IP data and the hydraulic properties will be investigated and developed by hydraulic reference data field tests. With the successful realization of the LINKIP project the ER (experienced researcher) will reach a unique position in the international scientific IP community by bridging the gap between the SIP (spectral IP) and DCIP communities. Together with the training by the luPOD program of the host organization she will improve her management, leadership and teaching skills significant. Collaboration with industry and authorities will be a vehicle for transferring research results to practical application.

Mots clés : environment, groundwater, management, protection, pollution, resistivity, spectral induced polarisation, frequency domain, time domain, tdip

Participants :
- Lund University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185857.2 €
Projet GlycoPDAC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive cancer type, with a 5-year survival rate of just 10%. This is primarily due to late-stage diagnosis and resistance to current treatments. Therefore, understanding the molecular mechanisms driving PDAC progression is critical for developing more effective diagnostic and therapeutic approaches. Glycosylation, one of the most prevalent post-translational modification, is fundamentally altered in PDAC. The two clinically significant subtypes present in PDAC, called Classical and Basal, have distinct glycosylation profiles that affect tumor cell biology and its interactions with the microenvironment and immune system. Despite its importance, the particular mechanisms involved are poorly understood. This project aims to elucidate how glycosylation drives PDAC, by characterizing the glycoproteins involved in different subtypes. We are particularly focus in the glycosylation enzymes GalNAc-T1 and GalNAc-T3, which have fundamental yet distinct roles in Classical and Basal cancer cells. However, their substrate proteins and underlying mechanisms remain largely unknown. Using bump-and-hole engineering, combined with click chemistry and mass spectrometry, we will pinpoint the glycoprotein substrates and glycosylation sites modified by these isoenzymes, offering unparalleled insight into the roles of glycans in PDAC. We will also characterize the biological functions of these glycoproteins through biochemical, cell biology, and immunological methods. By revealing how these glycoproteins influence cancer cell biology and immune recognition, this project could uncover novel mechanisms involved in PDAC progression, which can lead to the identification of new biomarkers or therapeutic targets, potentially improving patient outcomes.


Participants :
- Institut Francis Crick (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 260347.92 €
Projet AdoptART (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Every child has a unique identity, including her/his birth, name, nationality and family relations, among other elements. The UNCRC (1989) put the focus on the child’s best interests and the States Parties have an obligation to preserve the child’s identity and promote child participation. However, the issue of respecting children’s relationships and identities in adoption remains an area of uncertainty and ambivalence in adoption policies and practices. In addition, current adoption procedures do not provide opportunities for children’s meaningful participation. Children are the main stakeholders but, at the same time, the most absent and invisible actors. In response to this challenge and knowledge gap, AdoptART is a 24-month interdisciplinary, intersectoral and multi-method project which aims to co-create new knowledge and implement innovative strategies and methods that collaboratively involve children and other key stakeholders in adoption research, policies and practices. AdoptART is a multi-sited research project conducted in two countries: Spain (Europe), a Spanish-speaking country that has recently introduced the figure of open adoption, and Chile (Latin America), a Spanish-speaking country that is considering its introduction. The project connects my prior research experience in Chile with a two-way transfer with the AFIN Research Group (Universitat Autònoma de Barcelona) under the supervision of Professor Diana Marre. By examining the Spanish and Chilean cases, AdoptART aims to formulate policy guidelines for decision-makers and practitioners to strengthen a child-centric perspective in adoption research, policies and practices, in line with global adoption challenges and the European policies on the Rights of the Child.

Mots clés : adoption child participation children s right to identity qualitative methodologies participatory research chile spain

Participants :
- Université autonome de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €