Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet COFFEE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Actively seeking viable “clean/green” energy sources is essential for human to maintain sustainable development. Geothermal energy provides an important alternative to fossil fuels and gas in our life. However, most geothermal resources are deep-seated and are either deficient in fluid or permeability, or both. The deep-seated, dry, and tight geothermal reservoirs need to be hydraulically fractured for permeability improvement, thereby promoting fluid circulation and the harvest of heat energy for electricity production. This is often referred to as enhanced or engineered geothermal systems (EGS). Understanding the mechanisms that underpin the link between hydraulic fracture geometry and fluid injection scheme under heterogeneous geothermal reservoir conditions is essential in efforts to reduce the fluid-injection-induced seismicity during EGS creation and production. Within COFFEE, I will combine a multi-scale (laboratory centimetre scale, field decameter scale, and reservoir kilometre scale) approach to, for the first time, look at how the 3D hydraulic fractures propagate under geothermal reservoir conditions. My expertise with rock mechanics and discrete element method modelling and the vast knowledge on geothermal energy and advanced laboratory and field facilities at the host organisation will definitely create the optimal environment to deliver the objectives of COFFEE and promote the transfer of knowledge between all participants. The fellowship will be highly beneficial to establish myself as an independent researcher and junior professor at a leading European university. With this innovative multi-scale framework, I will improve the understanding of 3D hydraulic fracture growth in heterogeneous geothermal reservoirs. This understanding will provide insights on how to reduce fluid-injection-induced seismicity. The outcome of COFFEE can be used as a benchmark for geoscientists and policymakers in further exploring and optimising enhanced geothermal systems.

Mots clés : geothermal energy enhanced geothermal system coupled flow induced seismicity hydraulic fracturing

Participants :
- GFZ Helmholtz Centre for Geosciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet ERASMUS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Destructions left after an earthquake are mostly caused by high-frequency ground motion that originates from the seismic source. I will exploit the natural continuity between geodetic and seismological data to illuminate high-frequency sources and their relations with changes in earthquake rupture speed. I propose an innovative Bayesian 2-step kinematic inversion in the frequency domain to investigate these destructive and poorly constrained high-frequency sources. This probabilistic approach is based on near-field data and a detailed analysis of the model parameter uncertainties, which allows better locating the HF sources. The project will bring new insights into how high-frequency relates to tectonic features, both in subduction zones and large continental faults. ERASMUS will be a collaborative effort between different earthquake-related communities to generate knowledge that can be included in more reliable seismic hazard assessment, impacting society significantly.

Mots clés : seismogeodesy, earthquake hazard assessment, high frequency radiation, seismotectonics, geodesy gnss and insar , seismology kinematic inversion, strong motions

Participants :
- GFZ Helmholtz Centre for Geosciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet F-TRADEMARK (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Policies in developing countries that seek to fight hunger, achieve food security, improve nutrition, and promote sustainable agriculture (a United Nations Sustainable Development Goal), face considerable obstacles when confronted with disruptions of their staple food production and trade. Disruptions such as climate change along with inter-state conflicts, e.g., the ongoing Russian invasion of Ukraine, have weakened developing countries’ staple food yields, supply, and trade flows. For trade in particular, challenges include physical trade disruptions of agricultural outputs, as well as inputs, particularly in more vulnerable regions. These disruptions are often followed by government trade interventions. A critical dimension of food risk and security is staple food trade dependencies between countries. Such dependencies occur both directly, in terms of regional food security, and indirectly increase migration as well as gender vulnerabilities. Indirect dependencies emerge from the complex web of trade relationships in which a country's access to staple foods relies not only on direct imports from producing nations but also on re-exports facilitated by intermediary countries. In the case of disruption shocks, such a trade system may expose importing countries to vulnerabilities at various intermediary points. For example, the Russian-Ukraine war has exposed the vulnerability of countries directly importing staple foods and fertilizers from the two countries, but also heavily affected countries that rely on the re-export of staple foods. The project F-TRADEMARK aims to measure the vulnerability of nations’ food systems resilience based on global trade data from 1986 – 2020 using network-based assessment tools. Moreover, the future of staple food and fertilizer trade dependence will be predicted under different short-term and long-term shocks up to the year 2100.

Mots clés : food trade food securfood security unsdg staple food trade trade shocks climate change ukraine russia invasion gender vulnerabilities trade dependency networks ecologic network analysis

Participants :
- Université de Naples - Frédéric-II (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut international pour l'analyse des systèmes appliqués (Autriche) — Coordinator, beneficiary, Recherche, subvention : 199440.96 €
Projet CAP-MR-ADC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Electronic resonances are ubiquitous in electron-molecule scattering, appearing as metastable continuum states that underpin key physical and chemical processes like autoionization, Auger decay, and Interatomic Coulombic Decay (ICD). Unlike bound states, these resonances exist within the continuum and eventually decay, posing a significant challenge for traditional Hermitian quantum mechanics, which cannot directly map resonances to discrete states. To address this, non-Hermitian quantum mechanics offers a framework that allows the quasi-bound nature of resonances to be analyzed through bound-state methods. While one-electron decay processes are relatively well described by single reference methods, two-electron decay mechanisms, including Auger decay and ICD, are significantly more complex due to their dependence on multielectronic configurations, requiring advanced treatment of electron correlation. As a result, multi-reference methodss offer a more robust framework for capturing these decay processes. This project aims to develop an innovative, computationally efficient method based on multireference theory to study electronic resonances in strongly correlated systems. To achieve this, I will integrate the recently developed multireference algebraic diagrammatic construction (MR-ADC) theory with non-Hermitian quantum mechanics. Collaboration with experts across molecular resonances, spectroscopy, quantum dynamics, and quantum chemistry will ensure cross-disciplinary knowledge transfer, advancing our understanding of electronic resonances and their broader applications.

Mots clés : resonance, electron molecule scattering, non hermitian quantum mechanics, multireference algebraic diagrammatic construction mr adc theory, electronic structure, spectroscopic property

Participants :
- Université de Varsovie (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 179006.16 €
- KU Leuven (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet VM-AI (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : TERMINATED

The project will combine ideas from Artificial Intelligence (AI), Spiking Neural P (SNP) systems, and Virus Machines (VMs) that are a branch of Natural Computing that aims in developing unconventional computing paradigms inspired by biological structures and behaviors. The "mixing" of the first two seemingly different research fields comes from neurons, both fields have strong connections with modelling of neurons: the AI field is based on the artificial neural networks (ANN) architecture, while the SNP systems are based on the neurons of the brain metaphor, an approximation to the “spiking” activity. Recently, several bridges have been constructed from the spiking neurons with a young computing paradigm called virus machines, which abstracts viral replication and transmission, gaining attention in recent years due to the novelty computing behavior and the higher control of the computation due to an instruction network. We propose “virus machines and artificial intelligence” to focus attention on domains in which virus machines might offer superior performance over conventional and neural-like systems within artificial intelligence. We consider potential pathways towards virus machines and develop applications in time series prediction and image processing. Moreover, we explore new bridges and discussions between this and other well-established unconventional computing paradigms.

Mots clés : virus machines, spiking neural p systems, natural computing

Participants :
- Research Institute for Analytical Instrumentation (Roumanie) — Coordinator, beneficiary, Recherche, subvention : 98923.95 €
Projet MAPiT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Psoriasis, an autoimmune disorder characterized by keratinocyte hyperproliferation, predominantly manifests as plaque-type psoriasis, with a majority of cases being mild to moderate. Current treatment approaches, such as topical therapy, often fall short due to limited skin permeability. Systemic drugs and biologics, while effective, pose risks associated with high doses. Addressing mild psoriasis presents the challenge of overcoming limited skin permeability and minimizing systemic drug toxicity. Microneedle Array patches (MAPs) offer a promising alternative. They breach the stratum corneum, facilitating intradermal drug delivery, resulting in higher localized drug concentrations compared to systemic or topical administration. Given the pivotal role of TNF-α in psoriasis, I bring expertise in various MAP fabrication techniques, nanomaterials for drug and mRNA delivery, and their applications. By collaborating with the host, we aim to develop an innovative nanomedicine-based strategy. This approach involves encapsulating TNF-α inhibitors in calcium phosphate nanoparticles using flame spray pyrolysis and loading them into MAPs. The research will encompass various parameters, including size, encapsulation efficiency, release kinetics, mechanical strength, morphology, safety, and in vitro efficacy assessment. Beyond the research project, I will engage in personal development courses, gain exposure to state-of-the-art laboratory facilities, and participate in conferences. Additionally, I will mentor Master's and Ph.D. students, honing my project management skills, and collaborate with industry experts and clinicians to explore the formulation's potential.

Mots clés : flame aerosol nanoparticle synthesis, microneedle array patches, psoriasis, nanocarrier, immunotherapy

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
Projet PHOLOS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Lensed supernovae offer promising tools for cosmology with the upcoming revolutionary LSST survey, however the current techniques to both find these systems and to properly use them to infer the Hubble constant (H0) are severely underdeveloped. In this fellowship, I propose PHOLOS (Probing H0 with Lensing Of Supernovae), a three-part project to make lasting contributions to all steps of this process. I will first solve the longstanding problem of finding and prioritising lensed supernovae, by simultaneous exploitation of multiple datasets to find lensed supernova canidates without spectroscopic follow-up. I will then address the issue of the mass distribution of lensing galaxies (a recent systematic worry in all time-delay cosmography studies), by modelling population level characteristics of a large sample of lensed quasars. Finally I will combine the new lensed supernovae and mass model constraints in a cosmological inference pipeline that will scale to the hundreds of systems with heterogeneous data quality expected from LSST, yielding a precise and accurate measurement of H0. The timing of this project is ideal as LSST will start collecting data in mid-2023. By expanding my knowledge and (transferable) skills, this project will prepare me to be world-leading researcher thanks to new expertise on specific datasets like LSST and Gaia, on analysis techniques and machine learning methods, and on astrophysical phenomena like supernovae, gravitational lensing, and galaxy mass profiles.

Mots clés : observational astronomy

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet BioCaPHeal (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The increasing number of chronic wound cases, most frequently attributed to antibiotic-resistant bacterial infections, has set an urgent alarm since it causes low quality of life and even fatal complications to thousands of patients as well as burdens the healthcare systems globally. Antimicrobial biological drugs, also called biologics, are proposed to address the emerging and unmet threat of antibiotic-resistant bacteria in wound infections by developing antibiotic-free treatments with low immunological risk. Despite having maximal antimicrobial effect, biologics efficiency in infection treatment and wound healing is compromised due to their limited circulation half-life and susceptibility to environment and wound related factors. Hybrid nanoformulations (HNs) based on inorganic nanoparticles (NPs) are developed to perform biologics delivery by securing the integrity of their vulnerable structure and efficiency while they exhibit great potential in biomedicine as drug nanocarriers due to their stability, small size, and extremely high surface area. Here, we propose the synthesis of biocompatible and healing-promoting Calcium Phosphate (CaP) NPs with a nanomanufacturing process famous for its scalability and reproducibility, Flame Spray Pyrolysis. The as-prepared CaP NPs will be loaded with the biologics, peptide LL-37 and enzyme Lysozyme, to form novel hybrid drug delivery nanosystems. Synthesis parameters of CaP NPs and HNs nanomanufacturing protocols will be studied and their physicochemical characterization will be performed. The stability, the antimicrobial activity and the cytocompatibility of the HNs will be examined with in-vitro assays. Finally, the effectiveness of HNs in wound infections treatment and wound healing promotion will be tested ex-vivo. This project will provide fundamental insights on biological drug loading parameters on nanocarriers to facilitate rapid translation to clinics, after the intellectual property is protected.

Mots clés : flame spray pyrolysis, nanocarrier, biologics, infection

Participants :
- Université de Stockholm (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 103443.84 €
Projet DYNA-MIC-P (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Low P-availability in soils, soil degradation, over-application of P fertiliser and gradual depletion of P-resources are a threat for the sustainability of future agricultural production. Within soils, microorganisms play an active role in the cycling of P by: 1) storing P within their biomass, 2) mineralising non-plant available organic P, and 3) solubilising inorganic P forms . They are thus a key driver in the cycling of P in soil, both in shortterm (e.g. over a growing season), and in longer term, governing changes in soil P pools as soils develop. Greater insights in soil microorganisms’ role in cycling P in soil as a function of soil age, properties and management would create new opportunities for developing more sustainable agricultural systems that make better use of P, whilst simultaneously preventing losses to the environment. In this project I will investigate the interactions between soil P, soil microorganisms, and soil characteristics that promote microbial P cycling and P availability to plants along a managed soil chronosequence (Industrial partner: Inden mine, RWE Power AG, Germany (RWE)). The site represents a unique opportunity to study P dynamics under the effect of management practices and microbial processes over time. I will use state-of-the-art methods (e.g. isotopic and spectromicroscopic techniques) to deliver a better understanding of how soil microorganisms can regulate P availability in soil. I will address the following scientific question: How do soil properties, management and time affect P dynamics driven by soil microorganisms? I will carry out the research at the University of Copenhagen (Denmark) at the Department of Geosciences and Natural Resource Management (IGN), under the guidance of Assoc. Prof. Carsten Müller; and I will undertake a secondment to with the group of Plant Nutrition at ETH Zürich (Switzerland) under the supervision of Dr. Federica Tamburini.

Mots clés : phosphorus, soil microorganisms, chronosequence, plant available phosphorus, isotope, nanosims, nutrient balance

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
- École polytechnique fédérale de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet InSenS-3DCP (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

"InSenS-3DCP" presents an innovative solution to critical challenges within the realm of 3D concrete printing (3DCP). Safety and reliability concerns have hindered the broader adoption of 3DCP and the establishment of essential guidelines. Our project introduces an Integrated Inline Sensing System for real-time property assessment during 3DCP, precisely monitoring key properties such as yield strength, green strength, thixotropic behaviour, and interlayer bond strength by establishing the relationship between process parameters and sensors in the pumping system and printed structure. This allows for real-time adjustments of key process parameters, enhancing printing outcomes. InSenS-3DCP not only ensures successful printing and quality assurance but also aligns with the UN's Sustainable Development Goals, emphasizing sustainability. Our objectives encompass ambitious contributions, interdisciplinary approaches, and two-way knowledge transfer. The project will enable me to excel in sensor technologies, structural health monitoring techniques, and digital technologies through collaboration with esteemed European research groups. To maximize its impact, our strategy targets scientific communities, industry stakeholders, and regulators. We prioritize open-access publications and conferences to ensure broad access to our research. Engagement with industry and regulatory bodies guarantees practical applicability and policy making. The impacts of InSenS-3DCP span scientific advancements, economic growth, and societal improvements, ultimately contributing to refining construction processes and enhancing the safety, affordability, and accessibility of 3D concrete printing. InSenS-3DCP stands as a trailblazer, pioneering a safer, more reliable, and sustainable approach to 3DCP.

Mots clés : 3d concrete printing, quality control, inline sensing, structural integrity, sustainability in construction, process control, embedded sensors

Participants :
- Federal Institute For Materials Research and Testing (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet EngineeringSARCOMAs (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

One of the unsolved problems in cancer biology is why and how do certain oncogenic driver genes promote cancer in one cellular context but not in another. This project focuses on fusion oncogenes relevant to sarcomas, which are sarcoma type-specific and tumorigenic only in certain cellular states. By combining cell fate engineering of human pluripotent stem cells (hPSCs) with forced expression of sarcoma-linked fusions, I will systematically probe the cellular contexts and molecular mechanisms of fusion-driven sarcomagenesis, with the prospect of building novel disease models that could be used for testing new therapies. I hypothesize that fusion-driven sarcomas emerge from the combination of an oncogenic fusion protein and a cell-of-origin that is defined by a characteristic state prone to transformation. I will investigate the interplay between a specific cellular context and the activity of a particular fusion and whether a permissive cellular context is sufficient for fusions to execute their tumorigenic programs. I will pursue a “build it to understand it” approach and construct sarcoma models starting from hPSCs inducible for the expression of five sarcoma-linked fusions respectively. I will validate these models against single-cell and spatial maps of sarcoma tumors available in the host lab. I will exploit two complementary approaches for creating cells permissive to different fusion oncogenes: i. Programmed differentiation of hPSCs with precise molecular intervention in vitro (Objective 1); ii. Genetically engineered teratomas that could allow for full in vivo modeling of sarcomas (Objective 2). Alignment with the call: Innovative, collaborative, multidisciplinary project expected to qualify the applicant for a principal investigator position and an ERC starting grant. Candidate is promising early career female scientist moving from Italy to Austria. The candidate will bring her knowledge and new possible collaborations to the host lab.

Mots clés : pediatric sarcomas, disease modeling, transcription regulation, oncogenic fusion proteins, stem cell biology, crispr screening, single cell sequencing

Participants :
- St. anna kinderkrebsforschung gmbh (Autriche) — Coordinator, beneficiary, Recherche, subvention : 183600.96 €