Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet TRIANGLE (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Colorectal cancer (CRC) is the second cause of death in the EU, and so far, diet has been accounted for up to 80% of the cases. In this context, dietary phytochemicals have received increasing interest due to their suspected role in the prevention of cancer. Numerous studies report the chemopreventive effects of polyphenols. However, health benefits assigned to dietary constituents are still under controversy as can be deduced from the large number of applications rejected by the EFSA (health claims). Despite the crucial role of polyphenols in many biological cases, adequate tools to decipher the relationship between diet-microbiome-host are not yet available. To unveil the mysteries in the emerging field of personalized nutrition, this proposal aims to develop a new in vitro model for the study of phytochemicals in CRC prevention. The most common approach to study the anti-proliferative activity of polyphenols against CRC involves the use of 2D cell lines. Although multiple hints on the possible anticancer effects of these compounds have been already published, these results cannot be extrapolated to human. Firstly, immortalized 2D cell lines differ metabolically from in vivo cells. Secondly, these compounds were not artificially digested and fermented. Therefore, a novel integrative strategy to deepen understanding of CRC is vital. To accomplish this, a real-life scenario is needed. In this context, colon organoids/tumoroids will be established. Afterwards, an apple will be digested/fermented in vitro using a batch culture colonic model inoculated with feces from lean/obese healthy donors. In the end, such polyphenol metabolites will be tested in colon organoids/tumoroids and the mechanisms of action will be revealed by metabolomics and organoids assays. The outcome of this proposal will significantly deepen our knowledge of polyphenols-microbiome-organoids, and, in the long term, will allow nutritional recommendations to be given for the prevention of cancer.

Mots clés : apple, cancer, chromatographic separation, diet, digestion simulation, foodomics, gut microbiota, high resolution mass spectrometry, in vitro, metabolomics, organoids, phenolic compounds, 3d cell lines

Participants :
- University of Trento (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 168277.2 €
Projet NuSiCC (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Colorectal cancer (CRC) kills up to 170,000 Europeans annually. Although survival rates have improved gradually, new treatment strategies are certainly needed. Hyper-activation of WNT/Beta-catenin signalling occurs in up 93% of CRC cases and MYC appears to be an obligate effector of Beta-Catenin in the gut, making MYC an attractive target for therapeutic intervention. MYC, however, is difficult to target directly, owing to its lack of enzymatic activity or obviously druggable structural features. An alternative strategy is to target the biological consequences of MYC deregulation. The Murphy lab recently showed that MYC overexpressing tumour cells in culture exhibit an ectopic dependency on a little-known kinase called ARK5/NUAK1: whereas cells lacking MYC overexpression are able to withstand NUAK1 depletion or inhibition, cells with overexpressed MYC are unable to maintain energetic homeostasis in the absence of NUAK1, deplete their ATP levels, and consequently lose viability. We have therefor taken a genetic approach to examine the requirement for NUAK1 during tumour development in a genetically engineered mouse model of sporadic Beta-Catenin-driven CRC. Our preliminary results show that NUAK1 is required for CR tumour initiation and, more importantly, that NUAK1 depletion shrinks pre-existing tumours, suggesting that NUAK1 is an excellent candidate target for treatment of CRC. Based on these exciting preliminary data, I now propose to thoroughly evaluate NUAK1 as a target for therapy in CRC and to use a combination of proteomic, phosphor-proteomic and metabolomics analysis to determine the mechanism by which NUAK1 suppression erodes tumour cell viability.

Mots clés : nuak1, metabolism, colorectal cancer, spheroid culture, genetically engineered mouse models

Participants :
- University of Glasgow (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet PantEOn (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Combating the effects of climate change (CC) is one of the top priorities of EU policy. In order for CC mitigation & adaptation measures to be successful, they must be based on sufficient knowledge about ecosystems & how they respond to change, which is complex & not linear. The identification of spatio-temporal patterns & their relationship with the underlying ecosystem processes is one of the ongoing scientific challenges in which scale-dependency constitutes one of the principal pitfalls. Passive or active Earth Observation (EO) sensors offer a vital toolset to address this issue, by providing long archives at a variety of spectral & spatial resolutions, from the global (e.g. AVHRR), & the regional (e.g. Landsat) to the local, very high-resolutions (e.g. WorldView, Orthophotos, drones). The objective of PantEOn is to obtain empirical evidence about the long-term evolution & regime-shifts due to Climate Change of the functional & structural properties of Mediterranean ecosystems. This evidence is crucial for the identification of ecosystem resilience thresholds & the development of land degradation indicators. A multi-scale methodological framework will be developed in order to bridge the existing eco-hydro-geomorphological process-based knowledge of the Fellow, gained from 16 years of field experimentation & monitoring, with the advanced EO experience of the Hosts, to investigate & identify the spatio-temporal pattern/process relationships. The key for the proposed approach is to relate spatio-temporal patterns of vegetation with connectivity of soil surface components with respect to overland flow of water & sediments. The concluding objective of PantEOn is to provide an advancement in the design of operational indicators for the assessment & monitoring of land degradation, within the Land Degradation Neutrality framework suggested by the UN, in order to achieve the target of the Sustainable Development Goals to combat desertification by the 2030.

Mots clés : resilience, catastrophic shifts, time series, spatial patterns, land degradation neutrality, indicators, soil conservation, eco hydro geomorphological process, connectivity, multi scale, mediterranean

Participants :
- Manchester Metropolitan University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 319400.64 €
Projet CSA-EU (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Compact satellites are transforming space-based surveillance systems. Typical configurations include a network of small satellites that can offer increased coverage and enhanced data collection rates when compared to conventional large scale systems. Microsatellites can also drastically reduce launching costs and mission development time, thus making remote sensing technologies more cost effective. Applications include vehicle tracking, weather monitoring, maritime surveillance, crop growth analysis, and climate change observation. However, with satellite miniaturization, new design aspects arise. All satellite components have to be cleverly packaged within a small payload and materials must accommodate the harsh operating environments of space. The objective of the proposed research program is to research, design and test some new and compact antennas with integrated feed systems for such microsatellites. High levels of technical engagement are expected with satellite companies within the European Union such as the European Space Agency, Clyde Space, and PocketQube Shop. The intent of the proposed research project is to also benefit from ongoing research within the Microwave and Antenna Research Group at Heriot-Watt University. This group has a track record of developing new and innovative antenna designs, feeding systems, and filters for space technologies while also working alongside industry experts, technologists, and government scientists. Previous and current industrial partners include Airbus Defence and Space, Bell Labs Alcatel-Lucent, BSC Filters, COM DEV, Samsung, Huawei Technologies, Selex, and Thales Alenia Space. Some recent projects include planar antennas for onboard satellite antenna technologies and power amplifier design as well as compact antennas for microsatellites. Some of these activities have won awards from the European Space Agency and The European Conference on Antennas and Propagation.

Mots clés : antennas, microsatellite, microwave circuits, miniaturization, rf and microwave engineering

Participants :
- Heriot-Watt University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet EAR Stretch (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Complex contemporary music (CM) is the crucible for musical invention that exemplifies human creativity. It forms the lifeblood of musical cultural evolution, but can be alienating to the uninitiated. In EAR Stretch, we propose to help non-specialized listeners gain a deeper appreciation for CM through embodied interaction with temporal expression of the music. When communicating music, skilled performers often help listeners make sense of the music through expressive prosodic inflections of timing and tempo. In familiar music, listeners can often recognize the pulse and tap a foot along to the expressed beat. But in CM, listeners’ internalization of the beat and subsequent embodied reactions may be limited. The embodied cognition that comes from physically engaging with time—including organization of intrinsic brain activity and changes in perception—may be lacking in CM listening, contributing to poor reception. We hypothesize that empowering listeners to physically control the temporal expression of CM will lead to improved reception of the music as measured by neural and physiological changes and aesthetic evaluation of the music. Our main objective is to determine the impact of motor-based temporal engagement with CM on the listener-performer’s reception of the music. Acoustic- and complexity-matched CM compositions will be created specially for a psychophysiological study comparing normal listening to interactive listening with tapping-based temporal control. Objective measures, neural and physiological responses, will probe the underlying causes of subjective aesthetic evaluations and elucidate the roles of arousal, attention, and entrainment in these sources. Positive impact of interactive, embodied engagement with CM will transform the CM landscape, inspire the redesign of concert experiences, promote social inclusion, and propel CM into the musical vernacular, inciting cultural and intellectual development.

Mots clés : music perception and cognition, temporal perception

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 196707.84 €
Projet ReACT (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

Complexity theory concerns fundamental questions on the mathematics of computer science about the amount of resources needed to run programs or solve problems. The ReACT project will build on recent work in realizability models for linear logic to provide new characterizations of existing complexity classes. The end goal is to enable researchers to attack long-standing open problems in complexity theory by using mathematical techniques, tools and invariants from operators algebras and dynamical systems. The "complexity-through-realizability" techniques developed by the ReACT project will provide a unified framework for studying many computational paradigms and their associated computational complexity theory grounded on well-studied mathematical concepts. This will allow for comparison of complexity classes defined from different computational paradigms (e.g. sequential and quantum computation), as well as establish a theory of complexity for computational paradigms lacking such (e.g. concurrent processes). The "complexity-through-realizability" approach stems from established logical-based approaches of complexity theory and inherits their strengths. It furthermore improves crucially over them as it builds upon state-of-the-art theoretical results on realizability models for linear logic using well-studied mathematical concepts from operators algebras and dynamical systems. As a consequence, it opens the way to the use against the open problems of the discipline the many techniques, tools and invariants that were developed in these mathematical disciplines. The ReACT project has two objectives. The first objective aims at establishing this new approach to complexity as an emerging and promising field of study which generalizes and extends previous techniques. The second objective is to investigate investigating how the mathematical methods and techniques derived from of our approach can be used to attack long-standing open problems in complexity theory.

Mots clés : implicit computational complexity, linear logic

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet FULLCOMP (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : CLOSED

Composite structures are massively exploited in many engineering fields. For instance, the state-of-the-art civil aircraft (B787 and A350) are mostly made of composite materials. The design of composites leads to challenging tasks since those competencies that stemmed from the adoption of metallic materials are often inadequate for composites. Insights on many different disciplines and tight academic/industrial cooperation are required to fully exploit composite structure capabilities. The skills and the employability of young researchers increase to a great extent through an interdisciplinary and intersectoral training. The existing training schemes are often based on specific themes and disciplines rather than on a broad interdisciplinary and academic-industrial integrated approach. The main aim and novelty of this project is the creation of a multidisciplinary, intersectoral and international research training network based on a strong academic basis and industrial partnerships for a new generation of top talented young researchers that will work in the European academic and industrial scenarios. The multidisciplinary features are guaranteed by the presence of 7 universities, 1 research centre and 1 industry. The intersectoral approach will be pursued by including secondments and specific industrial training requirements in each individual project. The consortium is composed by partners from 8 countries. OTC partners were included for secondment and training opportunities; they were chosen on the basis of their expertise and to enhance the internationality features of the training. Their presence is seen as an opportunity for the European partners and researchers to strengthen competencies. The full spectrum of the design of composite structures will be dealt with - manufacturing, health-monitoring, failure, modelling, multiscale approaches, testing, prognosis and prognostic - to develop integrated analysis tools to improve the design of composites.

Mots clés : composite structures, design, manufacturing, health monitoring, prognosis, prognostic

Participants :
- Leibniz University Hannover (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 498432.96 €
- Luxembourg Institute of Science and Technology (Luxembourg) — Partner, beneficiary, Recherche, subvention : 501120.0 €
- University of Bristol (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 546575.76 €
- Polytechnic University of Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 774183.96 €
- Ausy engineering gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- Arts et Métiers Sciences et Technologies (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 525751.2 €
Projet DECOS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Computational chemistry is a modern and multidisciplinary subject, which underpins many areas of chemistry, physics, biology and material science. Due to recent advances in both theory and computational facilities, it is now quite clear that computational chemistry has reached the point where it should be considered as an equal partner to experiment and that in some cases it may even guide and unite the experimental efforts across multiple scientific disciplines. The proposed “DECOS” project (Unrestricted Divide-Expand-Consolidate Coupled Cluster Methods for Large Open-Shell Molecules), addresses one of the most challenging problems of contemporary computational chemistry: the ability of theoretical modeling to describe accurately large open-shell systems (molecules with one or more unpaired electrons) at affordable computational costs. To this end the Divide-Expand-Consolidate (DEC) scheme must be extended to unrestricted formalism. The new method constitutes crucial breakthrough because it combines linear scaling and rigorous error control of the established DEC scheme with the ability of treating large open-shell systems for biological and industrial use. Indeed, magnetic and catalytic properties, reactivity and spectroscopy often must be entirely attributed to special electronic structure of the open-shell systems. Additionally, through collaboration with Oak Ridge National Laboratory, the new methods will be implemented, tested and run on “TITAN” – one of the largest super computers in the world. Besides cutting edge science proposed in the project, it will also become a crucial step towards reaching professional maturity and independence in the applicant’s career. The project has potential for creating broad scientific impact and to establish long-term collaborations. Also, it assures the new knowledge will be secured, transferred and applied fully. The proposed developments will likewise be used and maintained for many years beyond the lifetime of the grant.

Mots clés : linear scaling, coupled cluster methods, open shell systems, first order molecular properties, molecular orbitals localization, ccsd, divide expand consolidate scheme

Participants :
- Aarhus University (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet NATCON (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Concrete structures are often strengthened by embedding steel ribs which is known as reinforcement in concrete. Prime setback of reinforcement in concrete is corrosion. Corrosion of reinforcements often limits the durability of reinforced concrete structures. In fact, the high alkalinity of concrete creates an environment that protects steel against corrosion. However, the life expectancy of concrete structures is affected by corrosion of steel reinforcements, because of an aggressive attack of chloride ions or as a result of carbonation. Corrosion of reinforcement has huge economic implications as well as social issues including endangering the safety of people who are working in industries. Corrosion inhibitors are among the methods that can be taken into consideration to reduce the steel bar corrosion. Corrosion inhibitors have been reported to control the corrosion of steel reinforcements without significantly changing the concrete properties. The environmental toxicity of the synthesized corrosion inhibitors has resulted in the search for finding green corrosion inhibitors with lower amount of toxic compounds. Among various compounds the corrosion inhibitors extracted from the plant products are inexpensive, readily available and renewable. Most parts of plants such as leaf, fruits peel, etc., are rich of the compounds that give them the capability to be used as corrosion inhibitor for various substrates in different electrolytes. Although some reports can be found in the literature regarding the use of natural corrosion inhibitors in concrete, not so many data are available on taking advantage of the synergism between inorganic inhibitors and organic compounds extracting from plant products. Accordingly, this study aims to examine the synergistic effect of some plant extracts and common inorganic inhibitors to The inhibition synergism of some plant extracts and common inorganic inhibitors to enhance the corrosion control of the embedding steel bars in concrete

Mots clés : concrete, steel rebars, corrosion inhibition, plant extract, green inhibitor, inhibition synergism

Participants :
- Carlos III University of Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 86466.24 €
Projet TODAM (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Conjugated polymers are drawing a constantly growing interest for modern energy technologies, particularly for the clean production of hydrogen fuel by visible-light photo-electrocatalytic water splitting. Although conjugated polymer catalysts are reported as stable, low cost and versatile materials, current synthetic approaches (solution-based) have prevented the study of the most interesting motifs and hindered the up-scaling of most conjugated polymers for practical applications. The central idea of the TODAM project builds on the recent achievements of the host group in the chemical vapour deposition (CVD) reaction of chromophore-based conjugated polymers, which will constitute a new field of research for the applicant. Notably, the TODAM project will combine the expertise of the applicant and the supervisor to expand far beyond the state-of-the-art of conjugated polymers while investigating the gas phase polymerisation of industrial dyes, i.e. DiketoPyrroloPyrrole (DPP) derivatives. In spite of their remarkable properties, including an exceptional light resistance and unique physicochemical properties, conjugated DPP assemblies remain a largely unexplored topic due to the lack of synthetic approaches. The broad knowledge of the applicant in organic chemistry, and more particularly his cutting-edge expertise in the field of functional dyes, will be used for the design and study of new homo- and copolymers. Finally, the scalability of the proposed CVD approach, readily forming thin films, will allow the integration of the new conjugated polymers as heterogeneous catalysts for photo-electrochemical water splitting. The formation, separation and transport of charges will be elucidated for the design and large-scale application of robust and efficient metal-free heterogeneous catalysts for the generation of clean solar-based fuels.

Mots clés : chemical vapour deposition, conjugated polymers

Participants :
- Luxembourg Institute of Science and Technology (Luxembourg) — Coordinator, beneficiary, Recherche, subvention : 178320.0 €