Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet RadCor4HEF (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

At High Energy hadron colliders, the wide phase space for particle emissions can compensate the smallness of the strong-interaction coupling of Quantum Chromodynamics (QCD). At the LHC this effect is crucial for production of mesons containing charm and bottom quarks. At hadron collider with energy of 100 TeV, all Standard Model physics will be affected by these large corrections.  RadCor4HEF's objective is to develop an efficient and robust method to match these phase-space corrections, provided by High-Energy Factorization (HEF) formalism with standard QCD computations in Collinear Factorization(CF). At present, this is not available. I aim at advancing the HEF including sub-leading corrections in the strong-interaction coupling within a new computational framework. I will apply it to study the production of (i) the eta_{c,b}-mesons in the LHCb kinematics, (ii) photoproduction of J/psi and Upsilon mesons (iii) hadroproduction of open heavy-flavour mesons.  For all of these observables the theoretical uncertainties are larger than the experimental ones and we will change this. The matched CF+HEF framework solves the instability problems of standard CF computations for eta_{c,b}, J/psi and open heavy flavour meson production at the LHC energies. RadCor4HEF will contribute to our quest to understand the proton structure and to predict heavy-quark bound-state production, which are the most poorly understood parts of QCD.  The science generated by RadCor4HEF will be disseminated via top-level publications, oral communications, outreach events and computing codes integrated in the EU Virtual Access "NLOAccess". Project activities will take place in the theory pole of IJCLab Orsay managed by CNRS, which gathers all the required expertise in the theory and phenomenology of QCD and particle physics. The exceptional environment part of Paris-Saclay U. will offer me an ideal training to develop my skills, to extend my research network and to become an independent researcher.

Mots clés : quantum chomodynamics, radiative corrections, pertubation theory, high energy colliders, heavy quarks, heavy quarkonia, lhc, fcc, factorisation and resummation

Participants :
- Université Paris-Saclay (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet MyoNanoCell (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Cardiovascular diseases are the leading cause of death worldwide, accounting roughly for 45% of all deaths in Europe and costing billions of euros to the European Union economy. Among these, most cardiovascular diseases, such as myocardial infarction, lead to the formation of heart scarring, which is the formation of fibrotic tissue that impairs contractility and cardiac function, ultimately causing heart failure. Despite the prevalence and serious consequences of heart fibrosis, current benchmark therapies have low long-term efficacy, and alternative novel therapies that have reached clinical testing still present severe limitations or lead to little improvement in cardiac function. Thus, there is still an urgent unmet need for the development of novel and efficient therapies for cardiac fibrosis. Cutting-edge research regarding the use of stem cells or delivery of molecules to induce cardiomyocyte proliferation are yet to be successful, as most of these therapies present challenges regarding immunogenicity, efficiency, and long-lasting effect. Thereby, MyoNanoCell project aims at developing a radically new platform for heart fibrosis and cardiac regeneration. By using a combinatory approach, where the MyoNanoCell nanohybrids incorporate not only the ability to carry different cardiomyogenic molecules, but also the ability to modulate the cardiac microenvironment and recognize cardiac fibroblasts, MyoNanoCell will radically increase therapeutic efficiency. Moreover, the simultaneous modulation of cardiac microenvironment and its repopulation with cardiomyocytes by fibroblast reprogramming will directly impact contractility and heart function, representing a paradigm shift in cardiac fibrosis therapy. MyoNanoCell will be fully characterized in vitro to have a full biological fingerprint on the process of cell identity shift, and also tested in advanced 3D in vitro models, to evaluate its overall effects at tissue level.

Mots clés : nanomedicine, nanoparticles, nanohybrids, cardiovascular drug delivery, fibroblast reprogramming, cardiac fibrosis, cardiovascular diseases

Participants :
- University Medical Center Groningen (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
Projet ETHOQS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Quantum entanglement plays a pivotal role in various interconnected fields ranging from quantum information, simulation, black hole physics to condensed matter physics, among others. This proposal aims at studies of novel models and observables which strengthen the connection between quantum many-body and holographic systems through the lens of entanglement. In first part of the proposal the expertise of the Host in quantum quenches in presence of symmetries is used to extend interesting questions in simple holographic models, which are expertise of the Applicant. The second part of the proposal plans to explore theoretical and experimental signatures of holography using many-body models realizable in present day quantum simulators. The goal of the action will be supported by a secondment in one of the leading institute for quantum information and simulations.

Mots clés : entanglement in many body quantum systems, holography ads cft correspondence , quantum simulations, syk model

Participants :
- École internationale supérieure d'études avancées (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
- Institute for quantum optics and quantum information of the austrian academy of sciences (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ZINMUNITY (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Recent studies have shown that plants locally increase zinc concentrations to fend-off invading microbes, a process in which Zn2+- ATPases HMA2 and HMA4 are essential. ZINMUNITY aims to unveil the molecular mechanisms controlling plant-zinc based immunity, connect it to the known defence signalling pathways, and determine the mechanisms allowing HMA2 and HMA4 to locally increase zinc levels. To do this, I will be trained in the patho-system Arabidopsis thaliana-Plectosphaerella cucumerina BMM, in metal imaging, confocal microscopy, transcriptomic and proteomic data analyses, and biochemistry of Zn2+-ATPases. In exchange, I will contribute with my experience in protein-protein interaction and in computational analyses of protein docking. At the end of this project, I should not only have placed zinc-toxicity mechanisms within the general plant immune responses, but also identified the molecular patterns triggering it, and determined the identity of the zinc-donor proteins to HMA2 and HMA4, impacting both the plant immunity and nutrition areas. As relevant will be setting the foundations for the development of new strategies of crop protection based on the use of zinc enriched bio-estimulants or fertilizers, with important societal (reduction of polluting/toxic and expensive pesticides), and economical implications (lower costs for farmers, new markets for the zinc-fertilizer industry). Moreover, this proposal will set the basis for me to reach a position of scientific independence, since ZINMUNITY will deliver a number of interesting genes for future characterization. This next career step will also be facilitated by many of the transferable skills acquired, such as grant applications, paper publication, research supervision and FAIR data management.

Mots clés : zinc transport plant defence plant immunity plant pathogen zinc homeostasis plant pathogen interactions

Participants :
- Université polytechnique de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet GlioSurg (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Malignant primary and secondary brain tumors represent the deadliest types of human cancer. Glioblastoma is the most common and the most lethal primary brain tumor. Standard of care is based on maximal surgical safe resection, followed by fractionated radiotherapy, with concomitant and adjuvant systemic chemotherapy. Despite optimal treatment, the recurrence rate is higher than 90%. On the other hand, brain metastases (secondary brain tumors from distant organs) remain a substantial contributor to overall cancer mortality, being the main cause of death in up to 50% of affected patients. Research on the resistance to chemo and radiotherapy has been widely performed; however, studies on the impact of surgery on the cellular biological phenotype have been curiously neglected even if the standard of care requires that all patients receive surgical resection if possible. The contribution of the neuroinflammation to cancer progression is extensively studied. However its role after surgical injury remains to be elucidated. Therefore, we aim to mechanistically decipher the role of reactive astrocytes (key regulators of neuroinflammation) on the post-surgery recurrence of primary and secondary brain tumors. We will use intravital microscopy, digital pathology, genetic and pharmacological selective targeting of reactive astrocytes and ultimately, we will evaluate novel therapeutic approaches to improve clinical benefit.

Mots clés : microsurgery astrocyte glioblastoma breast cancer brain metastasis intravital microscopy

Participants :
- Institut Curie (France) — Coordinator, beneficiary, Recherche, subvention : 209686.88 €
- Antoni van Leeuwenhoekziekenhuis (Pays-Bas) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet MetaboSignal (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Environmental stresses trigger metabolic changes that alter the internal carbon/nitrogen (C/N) balance in plants to promote tolerance at the expense of growth. However, the metabolic and genetic components involved in the precise coordination of the nutritional status remain largely unknown. MetaboSignal’s aim is elucidating novel signalling mechanisms governing nutrient balance by using C/N stress conditions as a proxy. This 3-year project proposes the integration of molecular genetics and biological chemistry disciplines to identify signalling functions of intermediate metabolites derived from C and N metabolism and characterize new nutritional sensors of C/N balance. Here, several innovative and powerful methods for chemical distribution mapping, proteomics and transcriptomic analyses are integrated in a convergent workflow with gene functional characterization to be carried out in cutting-edge institutions such as University of California San Diego and Universidad Politécnica de Madrid. Implementation of this multidisciplinary proposal will greatly bolster the fellow´s scientific profile and will uncover novel metabolite-controlled signalling pathways useful for knowledge-based improvements on plant nutrition and crop yield of scientific and societal relevance.

Mots clés : carbon nitrogen stress nutritional imbalance sugar signalling intermediate metabolites della proteins seedling stablishment

Participants :
- University of California System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université polytechnique de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 261380.64 €
Projet Farm-noise (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Tidal energy presents a promising solution for addressing the growing demand for sustainable energy. Extensive research efforts have been dedicated to refining individual turbine efficiency and optimizing tidal farms to maximize energy output. However, as tidal farms scale up, there's a consequential rise in noise emissions that can prove detrimental to underwater ecosystems. This issue necessitates a dedicated focus on the development of noise-reducing farms. While tidal turbine design has, to date, been focused on energy production, fatigue load and lifespan of the blades and paid little attention to the acoustic footprint and subsequent effects on the environment, it is urgent to design silent energy farms to reduce the noise impact on local fauna. Farm-noise intends to: 1) characterise individual tidal turbines and construct simple models (surrogates) for their representation; 2) provide mechanisms for the acoustic control/minimisation. We will characterize tidal turbines and farms using computational fluid dynamics and large eddy simulations. Based on the simulations and the extracted physical insight, accurate surrogate models for turbines and associated acoustics will be developed to enable optimization of farms that minimize noise while ensuring energy production. Machine learning based reinforcement learning methodologies will be used to optimize and control the trade-off between energy production and noise emission. Compromises between energy and sound generation will finally be reached automatically for specific sites taking into account ambient conditions and local fauna. The expected research results will not only provide theoretical and methodological support for the design and silent operation of large tidal farms but also promote the ecological sustainability of the tidal industry. The outcomes and impacts will be maximized and disseminated to various communities by peer-reviewed articles, conferences, workshops and outreach activities, etc.

Mots clés : acoustic tidal turbine large eddy simulation surrogate reinforcement learning machine learning optimization and design marine animals noise emission

Participants :
- Université d'Oxford (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université polytechnique de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet AMIN_MENA (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project has the overall objective to provide a broader understanding of conflict dynamics in Jordan and Lebanon and improve international organizations and EU programming on social cohesion and stability reducing the risks of internal social conflict outbreak in these countries. The action aims at assessing social cohesion in Jordan and social stability in Lebanon, by exploring internal conflict dynamics and identifying similar patterns and systematic differences. Moreover, it has the goal to identify concrete measures to increase social cohesion and stability in Lebanon and Jordan to reduce the risk of internal social conflict. Given the current state of affairs in the MENA region, the relevance and urgency of this study are paramount in terms of both timing and scope. This project is intended to provide crucial insights pertaining to social cohesion and stability to the EU for its external endeavors in the Middle East, with a particular emphasis on Jordan and Lebanon. This research not only addresses the existing gap in literature but also explores two case studies from both a top-down and bottom-up approach. It will employ a mixed-method methodology, with a significant focus on Participatory Action Research to ensure the inclusion of key stakeholder viewpoints in the research findings.

Mots clés : eu external action participatory action research social cohesion and stability

Participants :
- Université de Jordanie (Jordanie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Ca' Foscari de Venise (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 302052.2 €
- Université américaine de Beyrouth (Liban) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de l'Essex (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet LISTENINGS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The care of refugees is a pressing issue in light of the geopolitical context in both the UK and EU. Refugees, particularly those facing intersecting vulnerabilities related to gender and sexuality, are frequently subjected to various forms of violence, as shown in both academic and societal discourses. The project LINSTENINGS proposes an innovative interdisciplinary study in the field of psychosocial care for queer refugees, integrating art, psychoanalysis, and clinical writing. The aim is to enhance psychosocial listening practices through writing workshops with clinicians working with this population across public and private mental health services in the UK. In an interdisciplinary manner, the project seeks to map and analyze artworks created by queer refugees in the UK, creating a comprehensive portfolio and public archive. This archive will serve as interpretive material for symbolic analysis and a foundational resource for future writing workshops. Moreover, the project will develop an innovative methodology of "psychosocial cartography" through these workshops, promoting collective reflection on care practices while moving beyond the individualistic focus of traditional psychoanalytic methods. The research further aims to advance the study of gender and sexuality in psychoanalysis from a decolonial and intersectional perspective, focusing on the queer diaspora. With three primary research objectives and six work packages, this proposal merges artistic practices with clinical methodologies to establish a network of professionals and create an alternative counter-archive of care. Ethical and legal considerations regarding using images and sensitive data will be addressed, ensuring confidentiality and proper credit to the artists and participants. This project's anticipated impact is theoretical and practical, broadening psychosocial approaches and developing new ways of caring for marginalized populations through the integration of art and clinical care.

Mots clés : psychosocial psychoanalysis refugee care queer

Participants :
- Université de l'Essex (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet PITS3D (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Polymer informatics supports sustainable development goals by implementing versatile computational tools which allow users to move the polymer design from the laboratory to the digital world. To connect the links between the structure, properties and performance of the polymer materials, many pieces of puzzle need to be collected over a wide range of time and length scales, starting from the quantum and progressing hierarchically towards continuous methods. Due to their relative novelty, systematic bottom-up approaches for biodegradable polymers are in short supply. Owing to their rich structure stemming from the natural origin, they need to be simulated with a great detail, what leads to an increased computational complexity and researchers’ frustration. Consequently, the computational studies struggle to keep pace with the emerging applications and technologies such as additive manufacturing. PITS3D project aims to speed up the progress in the field by proposing a systematic bottom-up study of two biodegradable polymers widely used in 3D printing techniques. The atomistic description of the local processes of the selected samples represents the first pillar of the approach. In the second stage, the computational study is extended to longer time and length scales, while going beyond the state-of-the-art by mimicking the characteristics of commercially-produced biodegradable polymers. By providing the simulation input files as open-source starting packs, PITS3D aims to encourage the further development of these computational tools. Another objective is to bridge a gap between the theoretically studied systems and those used for the 3D printing, by establishing an iterative passage of properties between the computational and experimental techniques. The combination of both approaches optimizes the use of resources, providing economic and ecological benefits and represents a unique training opportunity for the fellow as well as for the students of the host institute.

Mots clés : biodegradable polymers, molecular dynamics simulations, rheology, additive manufacturing

Participants :
- Foundation for Research and Technology Hellas (Grèce) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Cadix (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 137760.8 €