Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet QSB (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : CLOSED

Modern physics has contributed to the development of powerful instruments and diagnostic tools for biology and medicine, with a direct impact on both our well-being and life expectancy. Today, it is timely to ask if the novel field of quantum information is ready to provide new methods for the life sciences. This proposal makes a step in this direction, introducing non-invasive quantum techniques for experimental biology, with potential applications to biomedical imaging. My goal is to show how quantum correlations (entanglement or discord) can be exploited to realize a fully non-invasive form of spectroscopy, which can be safely applied to fragile materials, such as photo-degradable biological samples (DNA/RNA) or in-vivo human tissues. These objectives are not met in today’s biology labs, where UV-light photometry heavily damages DNA/RNA samples, or in public hospitals, where X-ray scans expose patients to significant radiation doses, with non-negligible risks of cancer. The basic rationale behind the use of quantum correlations relies on their superior capacity to detect small variations in the absorption properties of the materials, even when only a few photons are employed. By exploiting this remarkable feature, I will prove the possibility of non-invasive testing of biological samples. My central task will be the design of a practical model of a quantum-enhanced photometer which is fully based on continuous-variable systems. This design will involve the extension of quantum sensing and metrology to a more advanced double-box formulation where two channels, representing seeded and blank samples, are simultaneously probed. The realization of such a quantum-enhanced instrument would allow for real-time continuous measurements of organic molecules and nucleic acids without any photo-degradation.

Mots clés : quantum sensing, quantum measurements, quantum entanglement, quantum technologies, quantum hypothesis testing, non invasiveness, biology, spectrophotometers, spectroscopy

Participants :
- Massachusetts Institute of Technology (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of York (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269857.8 €
Projet MANTIS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Motor neuron disorders (MND) are a spectrum of devastating diseases caused by motor neuron (MN) cell death. Recent findings revealed that DNA methylation is a hallmark of MN cell death. However, the cause and affected mechanisms leading to methylation increase remain mostly unknown, therefore limiting the design of therapeutic intervention. The discovery of a novel DNA modification has provided a paradigm shift in the understanding of DNA methylation and demethylation regulatory network. In fact, methylated cytosines (5mC) can be converted to hydroxymethylated cytosines (5hmC) by Ten-eleven-translocation (TET) enzyme family. 5hmC is found to be stably present in DNA and to influence gene expression as an epigenetic mark independent of 5mC. My preliminary experiments showed that MN death in a severe mouse model of Spinal Muscular Atrophy (SMA) is correlated to a genome-wide increase in 5mC levels and loss of 5hmC. This research proposal therefore aims to define the role of 5hmC and the TET family of enzymes in controlling MN pathophysiology. To address the common role of DNA demethylation loss in MND, I will investigate the methylation mechanism in SMA and another MND- Amyotrophic lateral sclerosis (ALS). The specific aims of this project are to (1) define the exact profile of 5mC and 5hmC in regulating gene expression in SMA and ALS via a genome-wide reduced representation sequencing; (2) test whether TETs interact with the Survival of Motor Neuron (SMN1) protein that is responsible for MNs cell death in SMA; (3) establish the therapeutic potential of a locus-specific demethylation in promoting restoration of the diseased epigenetic profile using the Crispr/Cas9 technology. These studies will greatly advance the understanding of the epigenetic regulation of MN cell death by 5hmC and TET proteins, and will set the stage for testing the therapeutic potential of these novel regulators in MNs disorders.

Mots clés : motor neuron, 5hmc, ten eleven translocation, dna methylation, dna demethylation, dna hydroxymethylation, spinal muscular atrophy, amyothrophic lateral sclerosis, survival of motor neuron  smn

Participants :
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 196707.84 €
Projet MuFFIN (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

MuFFIN - Modelling Foraging Fitness in Marine predators Recent technological advances have permitted the collection of novel high-frequency information about animal behaviour, physiology and characteristics of the environment in which animals move. Such technology-driven achievements are exciting, but it is important to analyse these data with a view to their original objectives: understanding individual behaviour, predicting population processes and optimizing species monitoring and conservation programs. Despite a growing number of tracked animals, long term movement dataset are a present-day achievement. As a consequence, while many studies of animal movements are motivated by questions on population dynamics, the explicit connection between the two is rarely attained. Through MUFFIN, I will make use of nearly ten years of high resolution bio-logging datasets collected on three species of top marine predators moving in environments difficult to monitor: Little penguins, Adelie penguins and Southern elephant seals. With these unique data, MUFFIN will answer questions related to effects of changes of availability of marine resources on breeding success, predators foraging behaviour, decision making and habitat use. I will (I) quantify changes in foraging behaviour across spatio-temporal scales, characterise type of foraging patches visited and energy spent. I will (II) model the effect of foraging patches visited, energy spent and environment encountered aiming to understand animal decision making, use of environmental features and changes in space used. I will (III) link foraging behaviours, effort spent and type of patch to breeding success, highlighting fitness consequences of changes of behavioural patterns. In accomplishing MUFFIN's objectives I will open powerful new avenues for the use and analysis of large high resolution movement data. These approaches are key for research seeking to optimise strategies for habitat management, species monito

Mots clés : foraging ecology, bio logging, movement ecology, animal decision making, marine predators, fitness, habitat use, population processes, marine spatial planning

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 196707.84 €
Projet INTERACTIVE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

INTERACTIVE is a multidisciplinary project that aims to understand how and when social interactions maintain behavioural diversity. We test predictions rooted in ecological and evolutionary theory to investigate i) how behaviours of social partners affect individual fitness (social selection), ii) how individuals adjust their behaviours in response to others (social plasticity) and whether plasticity is under selection, iii) how experience affects individual decisions. To answer our questions, we use ‘big data’ on human behaviour derived from a novel source, virtual ecosystems of cooperative multiplayer videogames. Our study system is the online multiplayer videogame ‘Dead by daylight’, where players repeatedly interact and cooperate to achieve a common goal. The project applies state-of-the-art theoretical and analytical tools from quantitative genetics and behavioural ecology to an exceptionally large, detailed, and complete dataset mapping behaviours of millions of players across millions of social interactions over years of gameplay. This unique dataset provides us an unprecedented opportunity to test, refine, and increase the predictive power of ecology and evolutionary theoretical models by overcoming empirical constrains common in research on nonhuman animals. INTERACTIVE combines the host’s expertise in quantitative genetics, selection analysis, and social evolution, with my strong background in behavioural and evolutionary ecology. I will develop analytical skills in high demand in the academic market, build a cross-disciplinary profile and strong ties with the industry, enhancing my competitiveness. This project is a vital step forward towards my career goals of reaching a position of professional independence in research and becoming a leading expert in the evolutionary ecology of social interactions. Findings from INTERACTIVE will improve our understanding of how social interactions shape the evolution of animal societies, including our own.

Mots clés : selection, indirect effects, behaviours, interacting phenotypes, reaction norms, plasticity, human behaviour, online multiplayer videogames

Participants :
- University of Exeter (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet INTERPHIL (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

INTERPHIL analyses the construction of philosophy’s disciplinary identity by studying the first ten International Congresses in Philosophy (1900-1948), relating them to the emergence in Europe of a new academic space that aimed at unity across different schools of thought. Today, the still persistent cleavage between the “analytic” and “continental” ways of practicing philosophy, hyper-specialization and hyper-production suggest that the project of a philosophical unity was not achieved. The majority of philosophers currently acknowledge the uncontrollable pluralism of the discipline and have abandoned the dream of a transnational community aiming at collectively defining the discipline and at discussing its main advancements. Still, this dream had important consequences, as it fostered the emergence of institutional spaces of intellectual exchange. At the beginning of the 20th century, for the first time in history, the International Congress in Philosophy, organised, then supervised by a French group over almost fifty years, aimed at achieving this philosophical exchange and unity. The group of philosophers involved got progressively larger, and had to arbitrate disputes between different participants and include or co-opt subalterns or self-excluded European and non-European groups, such as those from Russia. How did these actors deal with the contradiction between ambitions of universalism and rising nationalisms? INTERPHIL adopts an inter-disciplinary and multi-scalar approach in order to explain the constitution of a transnational philosophical space, the formation of philosophical ideas of Europe and the participation of philosophers in international institutions such as the League of Nations. The approach is socio-historical: bibliometric, lexicographic, sociological, historical and philosophical.

Mots clés : european union, global philosophy, analytic philosophy, continental philosophy, networks, bibliometry, encyclopedism

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 255768.0 €
- Université du Québec (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet INTREPiD (Horizon 2020, appel à projets 2016)
Action : Cofund Postdoctoral programme
Statut du projet : CLOSED

INTREPiD is an innovative 5-year Fellowship Programme that aims at recruiting 12 experienced researchers at the Centre for Genomic Regulation (CRG) located in the Barcelona Biomedical Research Park (PRBB), one of the largest biomedical research clusters in southern Europe. Fellows will be selected following an open, transparent, and merit-based process, based on international peer-review, and offered attractive working conditions in line with the European Charter and Code (the CRG was awarded the HR Excellence in 2013). Selected researchers will be able to develop their own project under the supervision of the group leader they select. They will be offered international, interdisciplinary and inter-sectorial mobility opportunities in a highly creative and dynamic environment supported by cutting-edge core facilities and a vibrant network of collaborators from academia and the private sector. INTREPiD will provide tailored mentoring and a comprehensive training programme, including up-to-date scientific and technological courses in a wide range of topics and disciplines, and modules on transferable skills, entrepreneurship, open science and career development. Mobility to national and international academic and non-academic institutes will be encouraged, in one of the partner organisations or in institutes that research labs collaborate with. Overall, the INTREPiD Programme will provide fellows unique skills and competences for developing a successful career in both the academic and non-academic sector. Thanks to the large CRG network of collaborators locally and internationally, the Programme will also catalyse sharing of best practice in experienced researchers training programmes across different institutes.

Mots clés : excellence, postdoctoral training, career development, mentoring, european charter and code, international, interdisciplinary and inter sector mobility

Participants :
- Fundació Clínic per a la Recerca Biomèdica (Espagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Esteve (Spain) (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut Curie (France) — Partner, organization partner, Recherche, subvention : 0.0 €
- Euvitro slu (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Ferrer internacional sa (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- CERCA Institution (Espagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Centre for Genomic Regulation (Espagne) — Coordinator, beneficiary, Recherche, subvention : 1274400.0 €
- Nikon (Japan) (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Novartis (Switzerland) (Suisse) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet IONBIKE (Horizon 2020, appel à projets 2018)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : SIGNED

IONBIKE proposes a research and staff exchange program will promote international and intersectorial collatorations in the topic of “Innovative Iongels for Bioelectronics”. The european consortium is formed by 4 European beneficiaries from which three are academic institutions such as University of the Basque Country (Spain), University of Cambridge (UK) and University of Bordeaux (France) and a high-tech company in bioelectronics named Panaxium from France and 5 institutions from third countries such as CONICET (Argentina), UCIMED (Costa Rica), Deakin University (Australia), KAUST (Saudi Arabia) and Georgia Tech (USA). The project proposes an intensive research and networking program between the european and non-european institutions in the area of new materials for bioelectronics. The scientific project tries to combine in a synergic manner the unique technical expertises of the different nodes. World pioneers in the areas of ionic liquids, iongels, (semi)conducting polymers, advanced materials characterization and (bio)electronic devices will work together towards a common goal. The project will pursue the development of devices for health and fitness monitoring such as long-lasting electrodes for electrophysilogical recordings for brain, heart and muscular activity or new all-solid organic electrochemical transitors. The exchange of Know-How will promotes the development of excellence science and innovation and helps to turn creative ideas into innovative products which will be exploited by the participating company PANAXIUM.

Mots clés : biopolymers, iongels, electrochemistry, bioelectronics, batteries

Participants :
- Deakin University (Australie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Bordeaux (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 91264.0 €
- University of the Basque Country (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 670358.0 €
- University of Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 280600.0 €
- King Abdullah University of Science and Technology (Arabie saoudite) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- National University of the Littoral (Argentine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- National University of Río Cuarto (Argentine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Panaxium (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 84778.0 €
- University System of Georgia (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Escuela autonoma de ciencias medicas de centro america (Costa Rica) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet IRB_DREAM (Horizon 2020, appel à projets 2019)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

IRB Barcelona is a world-class research centre conducting multidisciplinary research of excellence at the unique interface between biology, chemistry and medicine and devoted to understanding fundamental questions about human health and disease. One of the main missions of the Institute is to provide young life scientists with the opportunity to train and conduct research in a unique and multidisciplinary scientific environment. IRB_DREAM is an innovative initiative that will offer 10 four-year fellowships in two separate calls to young and talented researchers to undertake their PhD theses in one of the 27 laboratories at IRB Barcelona. IRB_DREAM seeks to revamp IRB Barcelona’s current PhD Programme by adding an innovative dimension, namely the customization of both the training offer and career development, to its already recognised excellence in research. To implement this enhanced training approach, IRB_DREAM not only counts on a unique training offer carefully designed to promote the 3i aspect but it particularly fosters much valued secondments and other initiatives aimed at enhancing the impact of the results and the career prospects of candidates beyond academia. In this regard, the objectives of IRB_DREAM are fully aligned with IRB Barcelona´s mid-term strategic objectives: to enhance the international visibility of the Institute, to boost translational research by devoting resources to new collaborations with hospitals, and to continue promoting knowledge and new technology transfer to the industrial sector. Fellows will be selected through an independent committee of experts, thereby ensuring transparency and equal treatment of all applications. All of IRB Barcelona’s research programmes will be open to applications from IRB_DREAM fellows. The IRB_DREAM programme will specifically bolster the career development of highly talented scientists and strengthen the biomedical sciences in general.

Mots clés : predoctoral training, career development, research of excellence, mentoring and supervision, 3i dimension

Participants :
- Institute for Research in Biomedicine (Espagne) — Coordinator, beneficiary, Recherche, subvention : 1084800.0 €
Projet INoVA (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Ice formation in the atmosphere has a major impact on the properties and lifetime of clouds yet is one of the least well understood processes indirectly affecting the Earth’s climate. Heterogeneous ice nucleation by airborne solid particles (‘ice nuclei’) exerts a profound influence on clouds by raising the temperature at which ice can form relative to by homogeneous freezing of supercooled water droplets. Volcanic ash from explosive eruptions is increasingly recognised to be capable of acting as ice nuclei but factors determining the ash ice nucleating efficiency have yet to be elucidated. As for mineral dust from arid and semi-arid regions, physicochemical properties of the solid particles such as crystallinity, mineralogy and composition likely play a role in their ice nucleating efficiency, but this remains poorly understood and has not been systematically investigated for volcanic ash. In addition, the influence of thermochemical processes/conditions in the source magma, in the eruption plume and cloud, and in the ambient atmosphere on ash ice nucleating efficiency is not known. The proposed research will address this gap in knowledge through an experimental approach uniquely bridging volcanic geochemistry and atmospheric science, to establish the link between ash ice nucleating efficiency and its physicochemical properties and magmatic, eruptive and atmospheric history. A range of natural ash and synthetic ash, generated and treated under controlled laboratory conditions, will be studied. Experimental data will be parameterised for use in model simulations to predict regional ice nuclei concentrations based on an Icelandic eruption scenario. Collectively, the proposed research, training and knowledge transfer activities will enhance the future prospects of both the Fellow and host, while contributing to the greater benefit of society by improving understanding of the potential impacts of ash emissions from explosive eruptions on the atmosphere and on climate.

Mots clés : heterogeneous ice nucleation, volcanic ash, physicochemical properties, clouds, atmosphere, eruption plume, climate

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €