Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet REPRO-NETS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The REPRO-NETS project aims to examine the impact and agency of conservative and progressive networks of non-state actors in shaping reproductive rights in Europe through strategic uses of law. The project examines recent "reproductive rights backsliding," where parliaments and constitutional courts, influenced by non-state actors, alter reproductive rights regulations, making reproductive rights in the EU increasingly dynamic and contested.  Moving beyond traditional legal analyses it adopts a socio-legal perspective focusing on three novelties. First, it investigates not only "high-profile" legislation and constitutional courts' judgments but also "low-profile" laws, such as health care regulations and WHO guidelines. Secondly, it explores the legal strategies and tactics of "pro-life" groups and "pro-choice" together, compares them, and investigates the dynamics between their legal actions. Third, it examines cross-border and transnational processes and knowledge transfers as these organizations operate beyond the national state.  Additionally, the project analyses the legal opportunity structures, strategies, and argumentation used by non-state actors, as well as the structural and institutional challenges of using legal mobilization in contemporary democracies. The main research question asks how transnational networks of non-state actors, both conservative and progressive, influence the reframing of reproductive rights in Europe through legal mobilization. This raises questions about how these transnational interactions influence reproductive rights reframing nationally and locally, how transnational ideas are translated into local settings by non-state actors, and why particular legal strategies are used over others. The project uses a mixed-methods approach, combining macro-level mapping and micro-level analysis. The findings will provide new insights into the legal strategies driving reproductive rights changes at national, European, and global levels.

Mots clés : legal mobilization reproductive rights socio legal studies lawfare transnational advocacy networks

Participants :
- Université Érasme de Rotterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 217076.16 €
Projet COMBATT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Aqueous batteries (ABs) hold great potential for large-scale energy storage due to their safety and environmental compatibility. However, they face a fundamental challenge as the redox potential for ion insertion overlaps with the limit of the electrochemical stability window of water. This overlap leads to severe H2 evolution reactions (HER) in ABs, reducing cell efficiency and causing side reactions. Despite its importance, the underlying mechanisms of the competition between ion insertion and HER remain poorly understood. This project aims to address this challenge by combining the experienced researcher's expertise in batteries and X-ray techniques with the host institute's expertise in interfacial electrochemistry and electrocatalysis.  We will develop a novel analytical platform, named X-Mass, designed to ensure compatibility between operando X-ray absorption spectroscopy and differential electrochemical mass spectrometry. Through the X-Mass, we will track the chemical composition of the active material and H2 gas production under consistent electrochemical conditions, allowing precise quantification of ion insertion (j-inst) and HER (j-HER) current densities. This will enable us to assess how both reactions vary and compete during battery operation.  To further understand the factors governing their rates and limiting steps, we will explore the effects of electrolyte and electrode modifications on j-inst and j-HER. Electrolyte properties will be controlled by additional cations (Cs+, Mg2+, Al3+, etc.), insertion ion species (Li+, H+), and salt concentrations. Electrode properties will be modified using different polymorphs of the model materials, TiO2 and WO3. This approach will deepen our understanding of their reactions particularly in relation to the double layer and electrode electronic structures.  Our project will provide new insights into the critical but fundamentally unexplored competition between ion insertion and electrocatalytic surface reactions.

Mots clés : aqueous battery, ion insertion, hydrogen evolution, competing electrochemical reactions, x ray absorption spectroscopy, electrochemical mass spectrometry

Participants :
- Université de Leyde (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 232916.16 €
Projet QUAER-TV (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

This proposal aims to develop a rigorous quantitative framework for analyzing electrocatalytic reactions, addressing a critical gap between experimental studies and theoretical models in the field of electrocatalysis. The project will combine Fourier-transformed ac voltammetry (FTACV) measurements on single-crystal electrodes (SCEs) with Bayesian inference techniques to validate and test kinetic models describing electrocatalytic reactions. The objectives are to: (1) Validate kinetic models for simple electron transfer reactions on well-defined surfaces, (2) Quantify the effects of reaction environment modifications on validated kinetic models, and (3) Extract with high-confidence reaction parameters for important electrocatalytic reactions like hydrogen evolution/oxidation and CO2 reduction The innovative methodology integrates the high kinetic sensitivity FTACV, the well-defined nature of SCEs, and the statistical power of Bayesian inference. This combination will enable rigorous model validation, parameter estimation with confidence intervals, and quantitative comparison between competing models. By establishing clear validity boundaries for kinetic models and relating physical processes to model parameters, this work will strengthen the foundation for accurate model-experiment comparisons in electrocatalysis. The outcomes will be significant for developing more active, durable, and selective catalysts, as well as advancing theoretical modeling of electrocatalytic reactions. The project will contribute to the development of electrochemical technologies crucial for reducing the environmental impact of energy and chemical production.

Mots clés : single crystal metal electrodes, electrocatalysis, fourier transformed ac voltammetry, microkinetic modeling

Participants :
- Université de Leyde (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 232916.16 €
Projet PhotoCage (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Biosynthetic polyene cycllization, where complex structures are obtained, represents an impressive example of Nature's a chemist. Organic chemists are trying to emulate the Nature to develop synthetic methodologies base on these cascades. It has been demonstrated that Photoinduced Electron Transfer (PET) can achieve this polyene cyclizations under milder conditions, as plants do during photosynthesis. In this context, fluorinated alcohols are very special solvents in organic chemistry due to their particular chemical and physical properties (e. g. strong H-bonding donor ability, low nucleophylicity). The combination of fluorinated alcohols with PET processes make this strategy unique for develop new biomimetic polyzene cyclization. To achieve PhotoCage 4 main research objectives should be implemented: (a) Design of the supramolecular cage photocatalyst and study of the interaction between them; (b) Application of the designed supramolecular cage - photocatalyst to polyene cyclizations; (c) Study of the reaction mechanims; (d) Impementation and development of an asymmetric version. The proposal also offers me a unique opportunity to develop transferable skills thanks to the courses proposed by Saarland University and Professor T. Gulder wich will be a valuable asset for continuing my academic career.


Participants :
- Université de la Sarre (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet STEMOX (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

ABSTRACT Breast cancer (BC) is the most frequently diagnosed cancer and the first cause of cancer death in women worldwide. In many tumors, including BC, there is a population of cancer stem cells (CSCs) characterized for unlimited self-renewal and being resistant to conventional cancer therapies eventually leading to tumor relapses and metastases. Breast CSCs (BCSCs) show high cellular plasticity and are capable of shifting between a proliferative epithelial-like (E) state and a quiescent mesenchymal-like (M) state. This plasticity of BCSCs facilitates their ability to initiate and grow primary tumors, invade the basement membrane, traverse tissue vasculature, and ultimately colonize distant organs to form clinically significant metastases. It has been recently proposed that redox regulation might play a significant role in BCSCs plasticity and aggressiveness. We hypothesize that the redox-regulated BCSC plasticity and the highly oxidative metabolism of E-BCSCs might be a vulnerability that could be exploited as a novel BC therapy. We aim to characterize BCSCs in terms of individual ROS production, transducing our breast cancer patient-derived organoids (PDOs) collection with genetically-encoded redox sensors. We will treat breast cancer PDOs with conventional chemotherapy and inhibitors of PI3K to study changes in redox signaling occurring in the tumor. Finally, we will attempt to target these cells and modulate their redox regulation in order to differentiate and eliminate them. We expect to better understand the redox-regulation of BCSCs, to subsequently modulate BCSC redox state to target and eliminate these cells, increasing conventional therapy effectiveness and decreasing the minimal residual disease and cancer spread in BC patients, contributing to overall survival.

Mots clés : breast cancer, cancer stem cells, redox, organoids, redox sensors, hydrogen peroxide

Participants :
- Université de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- Université de la Sarre (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet NETOPT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

In NETOPT, we will develop an innovative high-frequency forecasting model that analyses complex spatial and temporal dynamics in large-scale networks under demand and supply constraints. Using supply networks as an example, NETOPT aims to model and forecast large-scale network flows using a Functional Time Series (TS) and Mathematical Programming (MP) approach. The network model proposed in NETOPT can optimize decision planning and efficient scheduling by reducing financial and technical risks in transmission and distribution networks, such as gas and water networks. To demonstrate the practical effectiveness of our new approach, we will implement models to describe and predict hourly gas flows for several days ahead in the German high-pressure gas transmission network using real-world data. Efficient prediction and interpretation of the complex dynamics in transport and distribution networks is a crucial component of an intelligent decision support system that helps to reach the climate targets of the European Green Deal in a fair, cost-effective, and competitive way.

Mots clés : functional time series, energy forecasting, mathematical programming, dynamic network modeling

Participants :
- Université technique de Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet GHost (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This project will chart new territory in the study of the ancient Indian ritual texts of the Atharva-Veda (AV), the so-called “magic” Veda (c. 1000 B.C.E.). Because of its unorthodox elements, the AV has historically been overshadowed in India by the other three Vedas of the “high religion,” regarded as authoritative by later orthodox Hindu currents. The AV has been similarly neglected in research, despite the wealth of data it offers on marginal social strata through the oblique lens of its liturgical hymns. This project proposes to mobilize this data through a pioneering study focusing on the indigenous category of “hostile ritual.” It has not been noticed that while “hostile ritual” hymns calling for the death of an enemy exist from the point of view of both male and female agents, the chronologically later ritual manual devotes the “hostile ritual” chapter exclusively to male-oriented hymns, and makes hymns expressing women’s hostility a minor topic in the “women’s ritual” chapter. Do the hymns prefigure or contradict this later categorical separation by gender? To answer this, the hymns will be analyzed to detect any gendered sociolinguistic registers, a first for linguistic work on the AV, and the results of this analysis compared with details on ritual pragmatics from the manual. Since the AV’s core texts are still not fully edited and/or translated, this entails the critical edition from manuscripts of new hymns plus the first-ever translation into English of the hymns and of the relevant parts of the manual. The result, a case study for the dynamics of gender structuring through the prism of language and ritual evolution, will be a model for the meaningful integration of gender in text-based research. In terms of career development, this project will allow the researcher to broaden her expertise in historical linguistics, develop teaching experience, and expand the interdisciplinary potential of her work beyond South Asian studies.

Mots clés : atharvaveda, sanskrit, ancient india, manuscripts, philology, ritual, black magic, sociolinguistics, gender

Participants :
- Université de Leyde (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
Projet EReFaPhoc (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The world is currently on the verge of a new technological revolution, rooted on the possibility of harnessing unique properties of quantum mechanics such as entanglement to implement novel paradigms for computation. Semiconductor quantum dots are excellent candidates to become the sources at the heart of future photonic quantum technologies due to their capability of emitting single and even entangled photons. However, the presence of a fine structure splitting (FSS) between the excitonic levels significantly degrades the quality of the entangled emission from quantum dots and causes the latter to emit random entangled states instead of always the same Bell’s one: this pervasive problem has proved to be a major hindrance and prompted significant efforts to devise mitigation strategies. All the approaches implemented so far assume that, in order to prevent the degradation of entangled photon emission, its prime cause, the fine structure splitting of the source, should be removed. Several approaches have yielded excellent results in this sense, but at the cost of unwanted side-effects or increases in fabrication complexity and introduction of additional challenges for photonic integration. I propose to implement a complete paradigm shift in the search for a solution to this problem and show that entanglement restoral can be achieved after the emission of the photons from the source: as the latter emits a statistical mixture of entangled states when an FSS is present, and entanglement is not destroyed on a fundamental level, entanglement restoral can in principle be achieved by applying a sequence of logic gates that transforms any component of the ensemble to the same Bell state. I propose to implement this approach and show its superiority for integrated quantum photonics by developing the world’s first fast photonic circuit in a Lithium Niobate platform designed to manipulate polarization-entangled photons, and fully integrate a quantum dot on the photonic chip.


Participants :
- Université de Paderborn (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet WOmen-PRO (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

WOmen-PRO explores the life course of women in pre-pharaonic Egypt and Nubia, during the transition to complex society. Despite the volume of Predynastic research, women have been noticeably less investigated than men for this period. Therefore, WOmen-PRO's goal is to tackle the research gap on gender in the field, by investigating how this transitional period shaped the social role, identity and life course of women in the sample compared to men. To do so, I apply a cutting-edge, interdisciplinary biocultural methodology, combining methods such as palaeopathology, the study of entheseal changes, diet in view of dental health, mortuary archaeology and statistics. Analysis draws on osteological and funerary data of ~1500 adult individuals of both sexes from nine key sites in the region. WOmen-PRO’s objectives are: 1. To reconstruct female health status in view of rising social complexity; 2. To investigate aspects of female diet and how it may have changed over time; 3. To identify evidence of female physical activity levels over this transitional period; 4. To identify any correlates between funerary rites and the indicators of embodied life conditions, emerged from overall bioarchaeological analyses. WOmen-PRO will result in: the first collection of comprehensive female bio-social profiles for the early Nile Valley, with a comparative dataset from the male portion of the funerary population; an open source database storing the project’s data; a novel, interdisciplinary, non-destructive methodology to study gender and the life course, also beyond the specific context of the project. The Faculty of Archaeology at ULEI will offer high-quality training in the study of entheseal changes, dental analysis and the management of a bioarchaeology lab, via its director Dr Schrader. Such training will be key to both WOmen-PRO’s success and my career progress. Involvement in ULEI’s research and teaching will guarantee excellence in the two-way knowledge transfer with the host.

Mots clés : predynastic egypt, women, human remains, gender, bioarchaeology, funerary archaeology

Participants :
- Université de Leyde (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
Projet CFENPLs (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Nanoplastics (NPLs) are one of the most hazardous emerging environmental pollutants. We nevertheless still have a limited understanding of the precise toxicological mechanisms in living organisms. Herein, we propose a miniaturized electrochemical sensing platform combined with single-cell techniques to simultaneously and dynamically monitor the concentration of NPLs ingested by a single cell that is actually causing adverse effect and the release of toxicological markers (such as H2O2, H2S or specific DNA/RNA) from cellular damage. The implementation of this project is based on the innovation of the preparation technology of carbon-based microelectrodes functionalized with alkyl chain monolayer and recognition sites, which for the first time will be simultaneously integrated with single-cell analytical techniques for environmental risk assessment. Investigating the toxicology of NPLs at the single-cell level can avoid obtaining only the average expression of a population of cells and ignoring intracellular heterogeneity. Meanwhile, the toxicological concentration of NPLs and the type and concentration of toxicological markers will be efficiently matched, screened and quantified using machine learning, which can provide a phased and hierarchical understanding of the mechanism of toxicity evolution of NPLs in individual cells, and thus provide accurate references for the prediction of and early warning on the toxic effects of NPLs on living organisms. The development of this interdisciplinary technique is expected to not only broaden the understanding of the hazards of NPLs and reveal the evolutionary process of toxicity caused by NPLs, but will also provide an analytical platform for toxicological assessment of other types of pollutants. Moreover, it is promising to promote the commercialization of a portable device for the rapid detection of NPLs in water samples, which will provide a powerful tool for environmental protection and household water quality monitoring.

Mots clés : electrochemical sensing, living organism, toxicological concentration, nanoplastics, toxicological markers

Participants :
- Université de Leyde (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203464.32 €
Projet DMPdSAC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Heterogeneous catalysis has grown rapidly since the beginning of the twentieth century, and currently it plays a central role in modern industrial catalysis. Single-atom catalysts (SACs) have been recognized as one of the most active frontiers in heterogeneous catalysis, taking the advantage of maximum utilization of precious metals and their superior catalytic performance. SACs do not have static local coordination under reaction conditions, driven by their high surface energy. Understanding the dynamism of SACs under reaction conditions is therefore highly important. So far, all the dynamic process of SACs are all focused on the surface of the support. For the reduced metal oxide support, not all the single atoms (SA) are located on the surface, part of them substituted the metal from the bulk metal oxide support. Notably, the precious metal atoms could migrate dynamically between the bulk and surface of the support in response to certain reaction atmospheres. Such a three-dimensional dynamic process of SA could result in the direct change of active site numbers and the intrinsic catalytic performance of SA species, which could influence the catalytic activity significantly. However, such a process has barely been investigated due to the underestimate of their influence on catalytic activity and the limitation of operando and quantitative technologies. Thus, this project will focus on the dynamic three-dimensional migration of SA of Pd1/TiO2 during CO oxidation process. We aim to develop quantitative and operando methodology to analyze three-dimensional distribution of different Pd1 species, reveal how the dynamic process influences the active site numbers and the intrinsic catalytic activity of Pd1 species and establish the dynamic structure-activity relationship of Pd1/TiO2. The final aim is to provide guidelines for the design of high-performance SACs for a given catalytic process.

Mots clés : single atom catalysts, co oxidation, dynamic evolution of single atoms, three dimensional migration, in situ techniques

Participants :
- Université de technologie d'Eindhoven (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 217076.16 €