Projet SHIELD (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Medical implants have revolutionised healthcare by improving quality of life through replacing missing structures, restoring function, and promoting tissue regeneration. However, implant-associated infections (IAIs) undermine these benefits, particularly in orthopaedics, otology, and odontology, leading to chronic issues and substantial healthcare costs. IAIs, exacerbated by biofilm formation and antimicrobial resistance, pose a significant public health challenge. The SHIELD doctoral network aims to advance our understanding of IAIs, from their multifactorial pathogenesis to the development of new antibacterial biomaterials, bridging the gap between basic research and practical applications.  SHIELD is structured around three scientific pillars to advance IAI control strategies in orthopaedics, otology, and odontology: regenerative medicine, biomaterial science, and translational research models. These pillars drive research on therapeutic strategies, innovative biomaterials, and experimental proof-of-concept models. The network focuses on clinical studies, antimicrobial strategies for implants, and preclinical models to study IAI mechanisms.  Our goal is to train 16 young researchers through an interdisciplinary and translational approach, combining basic research with preclinical and clinical testing. In collaboration with 27 partners from 11 countries, SHIELD brings together expertise from multiple disciplines to bridge the gap between research and real-world applications. By developing new antimicrobial solutions for implants and conducting bench-to-bedside research, SHIELD aims to improve infection management protocols and patient care, significantly advancing the field of infection control in medical devices.

Mots clés : implant associated infections, translational models, biomaterials, biofilms, antimicrobial biomaterials, orthopaedic implants, hearing bone conduction, dental implants, regenerative medicine, bacteria

Participants :
- Heraeus medical gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Oticon medical ab (Suède) — Partner, associated partner, Autres, subvention : 0.0 €
- Public University of Navarre (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Turin (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281755.08 €
- Université technologique de Dresde (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 290272.32 €
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 973890.0 €
- Hospices civils de Lyon (France) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Vornia (Ireland) (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 341087.04 €
- Yellow research (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 348738.12 €
- University of Regensburg (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University College Dublin (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 341087.04 €
- Université d'Oslo (Norvège) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 339932.16 €
- University Hospital Regensburg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 580544.64 €
- Lyon-I université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'État du Montana (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Phaxiam therapeutics (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Anthogyr (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 314669.16 €
- Royal College of Surgeons in Ireland (Irlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University College Cork (Irlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- AO Foundation (Suisse) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Southampton (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Complejo Hospitalario de Navarra (Espagne) — Partner, beneficiary, Recherche, subvention : 282188.16 €
- Université de Birmingham (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 348738.12 €
- Corticalis (Norway) (Norvège) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Amicoat as (Norvège) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université autonome de Barcelone (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 282188.16 €