Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet GENDER-CF (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cystic fibrosis (CF) is a hereditary disease involving a defective ion channel, resulting in altered epithelial cell function and consequent infective/inflammatory airway exacerbations. Progressive loss of lung function is the leading cause of death in CF patients. It is statistically noted that females have a disadvantage in survival and morbidity; this is commonly referred to as the CF gender gap. Recent studies have implicated the female sex hormone, estrogen, in this gender gap. CF patients show altered microRNA expression and some of the affected miRNAs are predicted to target genes encoding key inflammatory mediators such as Toll-like receptor 4 (TLR4) and tumour necrosis factor a receptor associated factor-6 (TRAF6). This highly innovative proposal, to be implemented at the Royal College of Surgeons Ireland (RCSI), aims to study the regulation of key miRNAs by estrogen and investigate if this plays a role in the CF gender gap. I will combine my own expertise in pulmonary innate immunity with the host PI’s world-class knowledge of CF and miRNA research. The research will further our understanding of inflammation in CF to aid development of better therapies. I will develop professionally as I: a) diversify my competencies through the acquisition of new laboratory skills (e.g. qPCR, flow cytometry), b) strengthen my transferable skills (e.g. project management, public engagement, data dissemination) and c) expand my collaborative network through secondments to other world-renowned research teams in Leiden University Medical Centre, Netherlands and University of Heidelberg, Germany. I will contribute richly to research at RCSI as I am already equipped with skills applicable to ongoing work in the team and am keen to take an active role in student supervision. The opportunities carried by this fellowship will form the cornerstone of my career, accelerating my progression towards my goal of achieving a position of independence in respiratory immunology research.

Mots clés : microrna, cystic fibrosis, estrogen, toll like receptor 4

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet CFZEBRA (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cystic fibrosis (CF) is a life-limiting disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Chronic pulmonary infections accompanied by persistent neutrophil-dominated inflammation result in severe progressive lung injury and are the leading causes of morbidity and mortality of CF patients. In addition to known mucociliary defects, several lines of evidence suggest primary alterations in innate immune responses contribute to CF pathology. Currently, our understanding is limited by the lack of suitable animal models that recapitulate immune abnormalities found in CF patients. To address these unmet needs, I propose to develop zebrafish larvae as a tractable animal model to investigate the role of CFTR in regulating inflammation and infection. In preliminary data, reduced zebrafish cftr expression is characterized by more inflammation and increased susceptibility to infection with CF pathogens. In this fellowship, I will use this innovative model to recapitulate aspects of the CF microenvironment. Using innovative genetic techniques combined with dynamic imaging, I will elucidate physiological functions of CFTR in innate immune pathophysiology in CF and identify new therapeutic molecules active in a CFTR-deficient context to balance infection and inflammation to benefit patients with CF. Finally, I will confirm my findings in human CF macrophages. Using larval zebrafish gives a unique insight into immune cell function in CFTR deficiency. This will help guide future therapies aimed at correcting the innate susceptibility of CF patients to infective and inflammatory lung disease, with consequent improvement of their life quality and expectancy.

Mots clés : cystic fibrosis, inflammation, infection, zebrafish, anti inflammatory therapy

Participants :
- University of Sheffield (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet EnhancemenT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cytotoxic CD8+ T-lymphocytes (CTLs) recognize and kill infected and malignant cells. Although CTLs recognize tumour-specific antigens, they often fail to limit cancer growth, as the cancer micro-environment rapidly suppresses their functionality. Therefore, there is the need to unveil new molecular circuits controlling CTL activation, the process through which T-cells proliferate and differentiate into an antigen-specific subpopulation with effector functions. In this way it will be possible to enhance CTL tumour-fighting capacity and improve the efficacy of immunotherapies, especially against solid cancers. My project will focus on how post-transcriptional regulation of metabolism modulates CTL activation. Post-transcriptional responses are fast and important for adaptation to rapidly changing environments. RNA-binding proteins (RBPs) are fundamental modulators of post-transcriptional regulation of many cellular processes, but less is known about how they regulate metabolism. By combining multi-omics approaches (i.e. proteomics, transcriptomics, metabolomics and in-vivo experiments) I will investigate how metabolic pathways in CTLs are modulated by specific RBPs. I will study how these RBPs regulate the stability and the translation of mRNAs encoding metabolic enzymes. Finally, I will control the expression of these RBPs in CAR-T cells (engineered T-lymphocytes used in cancer immunotherapies) to regulate metabolic pathways and enhance the in-vivo solid tumour-fighting capacity of these cells. Thus, my research will lay the groundwork for the identification of new methods to stimulate metabolism of tumour-infiltrating CTLs to enhance their functionality. My expertise in RNA-biology will complement the new skills I will learn from my host lab and collaborators, combining diverse disciplines to investigate fundamental immunological questions and apply my findings to in-vivo cancer immunotherapy.

Mots clés : t lymphocytes, rna protein interactions, metabolism, post transcriptional regulation of gene expression, cancer immunotherapy

Participants :
- UK Research and Innovation (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 212933.76 €
Projet DATAMINE4.0 (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

DATAMINE4.0 is an IF for Career Development for Natasa Sarafijanovic-Djukic, PhD in Computer/Communication Sciences obtained from EPFL, Switzerland, a researcher in statistical modelling originally from Serbia, whereby she will work in IRIS, a Spanish R&D and advanced engineering SME. The project will study the modeling and analysis of data coming from complex industrial and organizational applications, in order to identify hidden causistic relationships in order to calibrate production and organizational control systems. It is highly multidisciplinary combining data science, statistics, artificial intelligence, telecommunications, specific engineering and organizational domains and information technology processing competences. In line with new paradigms such as Industry 4.0 and the Internet of Things. Although machine learning paradigms have been in existence for several decades, their penetration in the industrial and public organization setting has been limited. The goal is to build calibration and optimization models using advanced statistical and machine learning methods and other artificial intelligence inspired algorithms, for applications in which existing methods have been unsatisfactory. This will have a big impact on productivity and repeatability of winning formulas for key industrial applications such as customized production, public sector applications (e.g. optimization of urban mobility), and food processing. This is in line with findings published by the European Union. The developed data mining solutions will greatly enhance the current performance of the selected applications, allowing them a competitive advantage over current methods. The work will be done in an applied R&D environment in line with the objective for Dr. Natasa Sarafijanovic-Djukic’s career continuation. An engineering approach will be ideally completed with 7 formal scientific trainings, including two academic secondments, each of 2 months.

Mots clés : data mining, industrial process optimisation, data analysis, network analysis, data fusion, graph analysis

Participants :
- IRIS Technology Solutions (Spain) (Espagne) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 170121.6 €
Projet DEEPICE (Horizon 2020, appel à projets 2020)
Action : Doctoral Networks
Panel : Environment and Geosciences
Statut du projet : SIGNED

DEEPICE aims to train a new generation of European researcher (15 ESRs) working on scientific issues related to climate change in Antarctica by taking advantage of the unique scientific dynamic of the new European ice drilling "Beyond EPICA" which started in 2019 to extract a 1.5 million years old Antarctic ice core. The consortium gathers complementary expertise in instrumentation (for field conditions in extreme conditions or in the laboratory for the precise analysis of small ice samples), statistic tools as well as glaciological and climatic modeling from 10 different countries. The ESRs will carry out their individual research projects with a focus on an analytical or modeling subject in a strong interdisciplinary and intersectoral environment keeping in mind the importance of a combined data-model approach and with an active participation in science mediation in the field of climate change. The DEEPICE project will set up an innovative training program allowing the trained ESRs to acquire essential core and additional skills in instrumentation, ice core analysis, statistics and modeling, as well as a wide range of soft skills fostering their career perspectives. Especially, a thematic school will allow students to get in touch with different scientific mediators, publishers, journalists and political advisers. The research and training program gives an important place to scientific mediation and communication of obtained results to the general public and more specific stakeholders. After having completed the training, DEEPICE’s ESRs will be fully equipped for engaging in academic and non-academic careers related to glaciology, climate change, geophysics and instrumentation in geoscience.

Mots clés : antarctic deep ice cores, innovative instrumentation techniques, statistical and modeling tools

Participants :
- Ca' Foscari University of Venice (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 261499.68 €
- University of Bergen (Norvège) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 584684.64 €
- Université Libre de Bruxelles (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 256320.0 €
- Alfred Wegener Institute for Polar and Marine Research (Allemagne) — Partner, beneficiary, Recherche, subvention : 505576.8 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 549604.08 €
- Utrecht University (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 265619.88 €
- UK Research and Innovation (Royaume-Uni) — Partner, beneficiary, Recherche, subvention : 303172.56 €
- University of Bern (Suisse) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 562553.28 €
- University of Copenhagen (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 595044.0 €
- Lund University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281982.96 €
Projet DICTAPLOMACY (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

DICTAPLOMACY investigates an understudied dimension of authoritarianism – the use autocrats make of diplomacy as a tool of regime-survival. The project analyses and compares the foreign policy strategies and “dictaplomatic” tactics of four ideal-typical authoritarian regimes in post-Soviet Eurasia, with the aim of modelling the mechanisms whereby diplomacy serves them for external regime-legitimation and authoritarian consolidation. DICTAPLOMACY is a multidisciplinary project that combines insights and methods from comparative politics, international relations (IR) theories and foreign policy-making analysis. It elaborates an innovative framework for analysing rogue behaviour in contemporary IR. It departs from the idea that the EU’s democracy-promotion efforts in Eastern Europe require a better understanding of the foreign policy manoeuvres of post-Soviet authoritarian regimes. In identifying the international components of authoritarian resilience, DICTAPLOMACY also highlights which incentives and coercive means could limit the resilience and contain the diffusion of authoritarian governance. This is a timely endeavour, given the growing assertiveness of Russia in world affairs, and the emerging “nuisance” capacity of many of its undemocratic neighbours (Belarus, Azerbaijan and Kazakhstan notably) in regional affairs. Building on the researcher’s expertise in post-Soviet transition and the geopolitics of Eurasia, as well as on the leading academic experience of the host institution in diplomatic studies, the Individual Fellowship will provide the experienced researcher with a chance to acquire new skills, thus reinforcing her maturity as an IR scholar, as well as the host institution’s own visibility in the European Research Area. DICTAPLOMACY is a policy-relevant project with a strong potential to entail cross-disciplinary fertilisation between scientific research and policy-advocacy work as well, thanks to the researcher’s planned secondment in a think tank.

Mots clés : comparative politics  authoritarian regime, dictatorship, international relations theory  diplomacy, foreign policy decision making, post soviet eurasia  russia, belarus, azerbaijan, kazakhstan

Participants :
- Collegium Civitas (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 146462.4 €
Projet DIGITAL-FLOWS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

DIGITAL-FLOWS is a groundbreaking investigation of digital-native hip-hop culture, imparting new insights to European policy areas concerning Internet use, education, social equality, the creative economies, and connected communities. The overarching aim is to uncover and analyse the dynamic cultural politics of hip-hop music and community on the Internet, with three specific objectives: to design and apply a groundbreaking web-oriented, two-part methodology of data-driven and case-study research into online cultural networks; to apply musical, thematic, and political/feminist/critical race analysis to digital data objects (music, video, text) as expressions of hip-hop culture, politics, and aesthetics; and to generate conclusions on European priorities concerning online cultural expression, engagement, and education for sharing with policymakers. Among hip-hop's vast international listener base are many young and/or marginalised individuals, with unanswered questions about safety and security, communal opportunities, and wellbeing benefits of interaction with hip-hop's diverse and dynamic cultural expressions online. DIGITAL-FLOWS pioneers new approaches to these questions, generating high-impact outputs for academic and target audiences and policy recommendations concerning Internet use, education, and integration. The project will set a new benchmark in interdisciplinary studies of digital-native culture and provide a transferable model for web-oriented studies of popular culture more broadly. The research takes place in association with the CIPHER: Hip-Hop Interpellation initiative at University College Cork, an ERC funded team working in intersectoral collaboration with the Insight Centre for Data Analytics. Utilising UCC's CIPHER research network, DIGITAL-FLOWS' investigation of Internet-based music culture will establish me as a field leader in digital/popular musicology and inaugurate a cutting-edge methodology for the study of online cultural expression.

Mots clés : digital digital native hip hop internet gender race sexuality expression community politics streaming technology data analytics net neutrality archive discourse text thematic coding analysis

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184590.72 €
Projet DISCOVER (Horizon 2020, appel à projets 2020)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

DISCOVERing treatment from biomedical research (DISCOVER) is a doctoral programme, to be led by the Biotech Research and Innovation Centre (BRIC) at the University of Copenhagen. BRIC is a Centre of Excellence, with a primary goal of performing cutting-edge basic biomedical research in an open and diverse environment fostering interdisciplinarity and collaboration. Further, BRIC aims to offer outstanding research training of young scientists and translate research findings into societal value. In DISCOVER, we will recruit 24 outstanding international fellows to perform their PhD-projects in our state of the art laboratories in collaboration with a number of clinical environments. Our VISION is to empower diverse research talent to become creative and responsible researchers, with an ability to translate their biomedical research into clinical value. The past decades have presented great breakthroughs in the fundamental knowledge required for understanding and diagnosing many diseases. However, the ability to move basic discoveries towards new treatments is lagging behind the pace of discovery. DISCOVER’s ambition is to inspire and enable fellows to a research career bridging basic and clinical research. This will be done as a joint venture between BRIC and a number of clinical partner organisations. Three programme CORNERSTONES are central to pursue the vision: • Build bridge across ‘bed and bench’ • Discover approaches and tools to stimulate creativity and translation of research • Explore and implement sustainability in biomedical research With DISCOVER we will address an unmet need for closer ties between basic research and the clinic, through education of translational researchers with abilities move basic biomedical research findings down the path towards treatment. To widen their career perspectives, fellows will reflect on own competences and career goals and individually choose translational skill training and career activities to reach their goals

Mots clés : biomedicine, translational research, cancer, neurobiology, metabolic diseases, laboratory sustainability, research creativity

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1952640.0 €
Projet coDNAres (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

DNA double-strand breaks (DSBs) are the most hazardous type of DNA damage threatening genomic stability. Thus, eukaryotes developed different mechanisms of DNA damage response and DNA repair pathways which are highly conserved, but not fully understood. To keep a control between error-prone (Non-Homologous End-Joining, NHEJ) and high-fidelity (Homologous Recombination, HR) mechanisms of DSB repair is essential for cell fitness, mainly exerted at the level of licensing HR by the initial step of the pathway known as DNA end resection. Therefore, a full study of this step is essential to understand genetic diseases, as cancer, with a high potential to direct future therapeutic strategies. Cohesin complexes are high conserved factors with several roles in preventing genome instability. Cohesin are a tripartite structure ring-like where only the kleisin subunit differ, the meiosis-specific Rec8 kleisin substitutes its mitotic counterpart Rad21/Scc1. It has been described roles for cohesin in chromosome segregation and DNA repair, but as short, all based in providing close proximity of sister chromatids. But little it’s known about an active function in DNA repair further tethering DNA molecules, e. g. participating in the decision of NHEJ/HR pathway, mediating early DNA resection, or targeting other repair proteins to damage sites regulating the DNA damage response, all aims of this proposal. We will combine the expertise of the applicant in cohesin in nematodes and the host laboratory in DNA repair to shed light and compare the active contribution in DNA repair of the SCC-1- and REC-8-cohesin complexes. The use of Caenorhabditis elegans as model system will provide a portal to the study of systemic DNA damage response mechanisms in a tissue- specific way, here the mitotically proliferating undifferentiated germ cells, of great interest for the host lab.

Mots clés : dna repair, dna resection, dna damage response, cohesin, caenorhabditis elegans, rec8, scc1

Participants :
- Universidad de Sevilla (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160932.48 €
Projet COSMOS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : TERMINATED

DNA replication initiation is strictly regulated to ensure complete genome duplication. In eukaryotes, temporal control of origin firing across chromosomes establishes replication timing domains. Failures in the timing of replication initiation across chromosomes is implicated in DNA replication stress, a hallmark of cancer, but the function of these temporally restricted replication domains is not understood. As well as the duplication of DNA, S-phase involves the duplication of all chromosome structural elements and the complete separation of chromosomal intertwines. How this is achieved is poorly understood. A major hurdle for understanding how 3D chromosomal structures are duplicated in S-phase and inherited through mitosis is that current Hi-C methodologies do not give a distinction between chromatids during or immediately after DNA replication. This project aims to visualise the structure and interactions of replicating chromosomes by developing a new Hi-C method which will allow a separate analysis of each new sister chromatid during its formation. This will provide unique information about how DNA loops and interactions are replicated and resolved, preventing the accumulation of toxic chromosomal defects in each new daughter. This method will then be extended to address the impact of replication stress for the inheritance of chromosome structure. The project will result in a new understanding of the interplay of replication timing, DNA damage and chromosome structure, which may provide a novel framework to understand the causes of chromosomal aberrations that accompany tumour progression.

Mots clés : replication origins, hi c, replication stress, b compartments, replication timing domain

Participants :
- University of Massachusetts System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 271732.8 €