Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HARMFIX (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

This project is focused on the design and development of new rotor field excitation methods to achieve brushless operation for wound-field electrical machines (EMs). The proposed method will provide an opportunity to reduce the reliance of EMs on rare-earth materials of which EU is lacking its resources and eliminate the usage of brushes for their rotor field excitation while improving the reliability and cost-efficiency of the machine systems. Through this method, a new armature winding configuration will be developed to generate not only the fundamental magnetomotive force (MMF) but also a suitable harmonic MMF component in the airgap of the EMs, while powered from a single customary current-controlled voltage source inverter (VSI). The rotor of these machines will be altered to house both harmonic and field windings. The harmonic MMF component will be employed to induce a harmonic current in the harmonic winding of the rotor, which will be rectified to excite the rotor field winding to achieve brushless operation and develop torque. A new topology optimization methodology will be developed to optimize the windings and minimize copper consumption. The EMs employing HARMFIX do not require rare-earth materials, costly auxiliary electromechanical excitation systems or custom-made power electronics circuitry, or control strategies for their brushless operation. Therefore, this method is a truly viable and sustainable alternative for commercial products which are currently employing rare-earth materials, brushless exciters or brushes, and slip rings.

Mots clés : electrical machines

Participants :
- Université de Vigo (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Tampere (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
- Université de Newcastle upon Tyne (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ECrys (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : TERMINATED

This proposed project aims at opening new horizons in Grothendieck and Berthelot's theories of crystalline and rigid cohomology. These are p-adic cohomology theories that are used to study algebraic varieties in positive characteristic. In the last years, the subject has seen an incredible development. Recent important achievements have been, for example, Kedlaya's new proof of the Riemann Hypothesis in positive characteristic and Abe's construction of a p-adic Langlands correspondence for overconvergent F-isocrystals. On the other hand, there are still some fundamental open questions. The main weakness of the theory of rigid cohomology is the difficulty of performing classical geometric operations. For example, it is not known whether the direct image functors have all the desirable propreties (Berthelot's conjecture). This is mainly due to the fact that the definitions rely on differential forms, which need smoothness assumptions to be defined. The Applicant D'Addezio wants to use the edged crystalline site, a new site that he has recently constructed, to solve this issue. In particular, he wants to show that the edged crystalline site gives an alternative new definition of rigid cohomology and overconvergent isocrystals and then use this to prove Berthelot's conjecture. For this second step, he will exploit the fact that the definition of the edged crystalline site is completely algebraic. Other applications that will be developped include the construction of an integral structure for rigid cohomology and the construction of the category of F-isocrystals with log-decay for smooth varieties of arbitrary dimension (extending the results of Kramer--Miller).

Mots clés : crystalline cohomology, rigid cohomology, isocrystals, positive characteristic

Participants :
- Sorbonne Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet ActinStar (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Faithful epithelial morphogenesis is crucial during development and tissue homeostasis. The dynamic intestinal epithelium is an appropriate model to study this field of research. Constant regeneration of epithelium is one of the main characteristics of intestinal homeostasis mediated by finely controlled balance between intestinal stem cell proliferation and differentiation. Therefore, it is instrumental to study mechanisms controlling intestinal organization to understand tissue homeostasis and function.  Actin cytoskeleton plays an important role in regulating epithelial morphogenesis. Recently, by using 2D and 3D intestinal organoids, the host lab has discovered a new unique multicellular star-shaped actin assembly, termed “actin stars” (AcSs) located in the basal domain of differentiated epithelium. This network is characterized by 6-branched star-shaped actin clusters covering the entire basal surface, with AcS node at the centroid of the cell and each branch of the star orthoradially connects the plasma membrane, and directly mirrors a corresponding branch from a neighbouring cell. They confirmed such actin structures in vivo in mouse small intestine. The AcSs may represent a large-scale inter-connecting meshwork in the differentiated epithelial domain. Considering the novelty of these results, we would like to investigate the interplay between large-scale AcS networks and tissue morphogenesis. Here we aim to dissect the organization of AcS network, determine the processes leading to their formation, and understand the importance of AcSs for individual cells as well as epithelial assemblies. For that we will carry out a multi-disciplinary approach, combining the use of high-resolution imaging, optogenetics, genomics coupled to physical modelling. We anticipate that our results will have a significant impact in understanding the role of AcSs in epithelial differentiation, tissue homeostasis in physiological and pathological conditions.

Mots clés : actin cytoskeleton, actomyosin network, contractility, epithelium, intestinal organoid, cell shape, morphogenesis, mechanobiology, cellular biophysics

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet TADIM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Large molecules, i.e. molecules with more than 10 or even 20 atoms, have a huge potential to provide new data for the elaboration of new physics, from probing dark matter models, variations of fundamental constants or testing the Standard Model beyond what can be achieved by high-energy experiments conducted at large and very costly facilities. However, these large molecules can suffer from very complex couplings, making high-precision measurements almost impossible once a certain number of atoms, and thus of molecular complexity, is reached. When probing vibrations of the molecule (spectroscopically, in the IR frequency domain), couplings between different vibrational modes of the same molecule can induce large linewidths, and decoherence of the vibrational states. These vibrational couplings are called intramolecular vibrational redistribution (IVR) in the physical chemistry litterature, and are known since more than 40 years, but a detailed understanding of these processes is still lacking. Progress in that field is thus of paramount importance for the development of new experiments involving large molecules for the advancement of physics, and for the understanding of how vibrational energy is stored and can flow in a molecule.  The project will explore experimentally IVR in large molecules with cutting-edge spectroscopic tools, to progress in removing this major blockade in the use of large molecules to look for new physics. Probing IVR in a very detailed way is enabled by recent advances in the production of cold molecules and ultra-high-resolution mid-infrared spectroscopy. These new techniques will allow me to develop and demonstrate a new methodology to study IVR at an unprecendented precision. The main output will be a recipe to tailor IVR in molecules, from the molecular structure point-of-view, as well as the demonstration of unparalleled spectroscopic resolution on molecules with more than 20 atoms.

Mots clés : intramolecular vibrational redistribution buffer gas cooling mid infrared high resolution vibrational spectroscopy quantum cascade lasers frequency metrology precision tests fundamental physics

Participants :
- Université Sorbonne Paris Nord (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet WiSE-AMIBs (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

This project aims to develop innovative energy storage solutions by focusing on high-concentration salt electrolytes that protect manganese (Mn) anodes in aqueous batteries. Aqueous batteries, particularly those using Mn-based anodes, offer a safer and more sustainable alternative to traditional batteries, which often rely on hazardous materials and costly manufacturing processes. However, the challenge lies in enhancing the stability and performance of Mn anodes, which are prone to issues like hydrogen evolution, corrosion, and dendrite formation. To address these challenges, the project will explore the use of advanced electrolyte formulations, specifically water-in-salt electrolytes (WiSE), which have shown promise in stabilizing multivalent metal-ion batteries. By optimizing these electrolytes and investigating the interface between the Mn anode and the electrolyte, the project aims to create a high-capacity, high-energy-density battery with enhanced safety and longevity. This research has the potential to contribute significantly to energy storage technology, offering a pathway to safer, more efficient batteries. The findings could also play a crucial role in reducing Europe's reliance on non-renewable energy sources, aligning with broader goals of energy security and sustainability.

Mots clés : advanced manganese chloride electrolytes, high density energy storage, sustainable battery technology, aqueous electrolyte innovation, safety in energy applications, environmental impact reduction

Participants :
- University College de Londres (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet NC-DNA-INS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The insulin-linked polymorphic region (ILPR) resides in the promoter region of the gene coding for insulin (INS). This region consists of a 14-base pair tandem repeat DNA sequence of 5'-ACAGGGGTGTGGGG-3'/3'-TGTCCCCACACCCC-5' and is located 363 base pairs upstream of the transcription start site of insulin. The insulin-linked polymorphic region can form non-canonical DNA secondary structures such as G-quadruplexes, i-motifs and hairpins. Previous work at the UCL School of Pharmacy has shown that different native insulin-linked polymorphic region sequence variants form different DNA structures and these result in differences in insulin gene transcription. This project aims to reveal insights into the relationship between different DNA sequences in the insulin promoter region, the types of non-canonical structures they form, transcription of insulin and how this is influenced by small molecule ligands. The project will use biophysical approaches to determine the structure of different sequences in the insulin promoter, cell and molecular biology to understand the effects of different sequences and structures on insulin expression, including using small molecule ligands as probes. Finally, computational biology and x-ray crystallography will be used to design improved compounds that target the insulin-linked polymorphic region and switch on insulin transcription using structure-based rational design.

Mots clés : dna, i motif, g quadruplex, non canonical dna, gene expression, epigenetics, chemical biology, insulin, diabetes

Participants :
- University College de Londres (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet SImPloidy (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Sarcomas are a diverse group of rare cancers that originate from mesenchymal tissues. The rarity and intrinsic genetic complexity of sarcoma have made it one of the most challenging tumours to diagnose and consequently, to treat. A key genetic characteristic of many sarcoma subtypes is aneuploidy. Aneuploidy is defined by losses and gains of chromosomes, and is a prognostic marker for a variety of sarcomas. Currently, tumour ploidy are most commonly estimated using copy number alteration calling software on whole-exome and whole-genome sequencing data. However, the unsatisfactory accuracy, economic costs, infrastructure requirements, lack of trained personnel in interpreting the results is still an impediment to global adoption of these techniques for routine use, particularly in less developed economies. The goal of this research is to develop a more accessible and more accurate approach for predicting tumour ploidy based on Hematoxylin and Eosin (H&E) stained whole slide images. The specific aims of the project are to 1) optimise a nucleus segmentation model for annotating sarcoma nuclei in H&E images, and predict tumour ploidy at single-nucleus level, 2) thoroughly validate image ploidy and systemically compare it with existing ploidy estimation methods, 3) evaluate the diagnostic and prognostic value of the image ploidy, and investigate its underlying biological mechanisms in pan-sarcoma.  This work will be carried out at University College London and the Royal National Orthopaedic Hospital, under the supervision of Prof. Adrienne Flanagan and Dr. Nischalan Pillay. The host labs have collected and scanned whole slide images of more than 40 types of bone and soft tissue sarcomas from more than 8000 cases, of which 1,600 cases have paired WGS and transcriptome sequencing. The access to this unique dataset will give an unprecedented opportunity to study ploidy at single-nucleus level in pan-sarcoma.

Mots clés : chromosomal instability, single cell ploidy, digital pathology, computational biology, sarcoma

Participants :
- University College de Londres (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet SECURE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In recent years, promoting LGBTI+ rights and countering disinformation have become pressing priorities for several Western governments. Due to the potential for disinformation to fuel discrimination, hostility, and violence against vulnerable groups, these two objectives are increasingly intersecting in local, regional, and international political processes. To regulate disinformation, particularly on social media, state actors worldwide have primarily resorted to a security rhetoric, presenting the issue as an existential threat to security, human rights, democracy, and the rule of law. While many scholars have explored how disinformation campaigns are impacting the advancement of LGBTI+ rights, we still know very little about how this specific agenda has been incorporated to justify the securitisation of disinformation. Even less is known about the role LGBTI+ civil society has played in this process—a sector that is highly affected by the spread of false narratives but is also increasingly reliant on the services provided by these platforms to connect with the community, launch awareness campaigns, and raise funds. How they position themselves vis à vis the state, private sector and other actors in the regulation process? And how is the engagement in this field shaping the claims of LGBTI+ organisations for “protection”? SECURE will analyse how the security discourses and practices from the anti-disinformation field are spilling over into LGBTI+ rights. Through a comparative study between Poland and Brazil, two countries that have recently experienced intense polarisation around LGBTI+ rights related to the spread of disinformation, the project will develop a transferable theoretical framework to analyse multilevel security spillover processes and theorise about the current shift from “equality” to “protection” in “LGBTI+ governance”—the ways in which LGBTI+ people and ideas are incorporated into state, state-like, and state-affiliated power.

Mots clés : disinformation securitisation lgbti rights lgbti civil society lgbti governance internet governance international relations political sociology

Participants :
- Université libre de Bruxelles (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University College de Londres (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet DaNSEC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Chronic pain is a major public health challenge in the EU. Fibromyalgia (FM), a common chronic pain condition, disrupts both bodily self-consciousness and its connection to that of others (the social bodily self). No cure and complex symptomatology lead to invisible disability, alienation and social difficulties, creating an urgent need for new theoretical approaches and treatments. One of the most effective interventions is dance, although there are no specific dance training protocols for FM, and the mechanisms in dance responsible for its health benefits remain unknown. In typical adults, moving in synchrony with others triggers interpersonal neural synchrony (INS) (of movement, physiological function and brain activity), which increases bonding and reduces pain. It is unknown whether people with chronic pain experience the same INS and how this may affect their bodily self and social connectedness. Therefore, our aims are: 1) to co-design and validate a dance protocol for investigating INS in FM, and 2) to investigate the effects of social (vs individual) dance on the social bodily self in FM to reveal the role of INS in these effects. Our project is based on a participatory design and a robust experimental plan, including a randomised controlled trial. We will use functional near-infrared spectroscopy hyperscanning, physiological recording, and precise body tracking to quantify INS during dance in people with pain and pain-free controls. The key impact of DaNSEC will be new high quality knowledge, made possible by the complementary expertise of two world-class advisors in interpersonal synchrony (lead advisor) and dance (co-advisor). The results of this project will open up new avenues to explore the therapeutic potential of interpersonal synchrony for FM and other chronic pain conditions. The fellowship will complement my expertise in FM and the bodily self with knowledge of INS and dance, and will be a major step towards becoming an independent researcher.

Mots clés : fibromyalgia, bodily self awareness, chronic pain, dance, interpersonal synchrony, fnirs, multisensory integration

Participants :
- Associacio catalana d'afectades i afectats de fibromialgia i d'altres sindromes de sesibilitzacio central (Espagne) — Partner, associated partner, Autres, subvention : 0.0 €
- University College de Londres (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 345234.9 €
Projet HydroCORE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Hydroelectric power is a popular alternative to burning fossil fuels, especially within the Amazon river basin. However, no single hydropower installation is without any environmental impact. By damming a river, significant alterations do occur in the hydrological connectivity, which reverberate in the river’s morphological state and physicochemical conditions. Moreover, consequent changes in the structure and functioning of the aquatic community have a tendency to negatively affect various ecosystem services, thereby putting local societies at risk and undermining the goal of sustainable development. Various qualitative global assessments have certainly helped illustrating opportunities and threats, but have failed to be compatible with local management needs and ecological perspectives. Therefore, the aim of this research is to monitor, analyse, evaluate and illustrate the impacts of reservoir-based hydropower infrastructure on the morphology, hydrology and quality of Andean headwaters within the Amazon river basin by combining (i) remote sensing, (ii) process-based hydrological modelling and (iii) water quality assessment based on field campaigns with a high temporal resolution. Additional focus is directed at the interaction with climate change, including the contribution through emissions of greenhouse gases (field measurements) and the challenges under future climate conditions (modelling). To do so, the Paute river basin (Ecuador) is selected as study area to (i) overcome the local data scarcity, (ii) develop a protocol for evaluating similar systems and (iii) preserve the uniqueness of these headwater ecosystems. Project activities and obtained results will be publicly accessible and continuously disseminated online and in-person. As such, this research will increase local and global understanding of and reduce the environmental impacts associated with reservoir-based hydropower installations.

Mots clés : hydropower, impact, freshwater, remote sensing, hydrology

Participants :
- Université de Gand (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 238764.48 €
- University of Cuenca (Équateur) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €