Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet COL_RES (Horizon 2020, appel à projets 2020)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

The COL_RES network comprises a world-leading group of investigators that will investigate the mechanisms by which the gut microbiota protects against serious foodborne pathogens (Salmonella, E. coli, Listeria, Citrobacter and Campylobacter) and lead to the identification of next generation probiotics that can protect against multiple infectious agents. Through intersectoral industry-academia secondments the network will provide state-of-the-art training for early stage researchers (ESR) preparing them for problem solving and entrepreneurial roles in industry and society and underpinning cutting-edge research in infectious disease in the EU. Food and water borne diseases cause 23 million illnesses in the European region with 5000 deaths per annum and represent an increasing challenge to the health of the EU and global population. Through studying different pathogens using shared approaches the COL_RES network will undertake a network-wide approach to identify overlapping mechanisms by which members of the gut microbiota provide a barrier to infection through the phenomenon of Colonization Resistance. The work will utilise a systems-based approach by exploiting existing research models at world-leading laboratories combined with phageomics, metabolomics and bioinformatics to generate multi-omics data that will uncover both pathogen-specific and shared mechanisms by which the gut microbiota protects against foodborne pathogens. The work will inform the selection and testing of specific next-generation probiotic candidates that can protect against foodborne infections, with potential for further development by our industry partners. Thus, the network will enhance training through world-leading research via cross-sectoral industry secondments in an actively entrepreneurial environment.

Mots clés : microbiome, microbiota, infection, immunity, foodborne pathogen, salmonella, listeria, campylobacter, e  coli

Participants :
- Charité - Universitätsmedizin Berlin (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 824052.96 €
- CERCA Institution (Espagne) — Partner, beneficiary, Recherche, subvention : 250904.88 €
- Board of the Swiss Federal Institutes of Technology (Suisse) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281276.64 €
- Université Clermont Auvergne (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274802.04 €
- Imperial College London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
Projet COMPASS (Horizon 2020, appel à projets 2015)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : CLOSED

The COMPASS project unites key players in Europe and the US with the aim to advance the field of colloidal nanocrystal (NC) synthesis and assembly and their exploitation in photonics, sensing, energy conversion and medicine. COMPASS aims to (i) develop colloidal NCs with desired properties by controlling their size, shape and composition, and to demonstrate routes allowing for large production volumes with nearly identical size and shape; (ii) develop approaches for NC self-assembly in ordered superlattices constituting NC solids with novel properties; (iii) understand the optoelectronic properties of novel NC-based materials by advanced optical and scanning probe spectroscopy methods, and explore pathways for their implementation in light emission, sensing, energy conversion and medicine; (iv) establish a consolidated network between leading EU and US institutes to provide a stimulating international environment for talented young researchers; (v) advance the level of R&D in Europe and the US and foster technology transfer and dissemination; (vii) raise the awareness of the general public on the prospects of NC materials in future technologies. Young scientists will be formed by "training by research" in long term stays at host labs and by lecture series held in the network that cover specific research topics, technology transfer and management/communication skills, leading to an interdisciplinary and international formation. The exchange will consolidate existing initial links between some of the lead scientists in COMPASS and establish a long lasting network that will have strong impact on science and education with significant repercussions in industry. The work plan is divided in 5 strongly linked workpackages that deal with Management, NC Fabrication, Self Assembly and Surface Functionalization, Photonics and Optoelectronics, and Energy Conversion. COMPASS will be guided by an executive board that consists of the coordinator and the lead PIs of the partners.

Mots clés : cation exchange, upconverting nanoparticles, nanocrystals, nanowires, catalysis, biomedicine, energy conversion, superlattices, self assembly, optoelectronics, lasers, plasmonics

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 324000.0 €
- Cornell University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Columbia University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Ghent University (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 225000.0 €
- Utrecht University (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 103500.0 €
- Ludwig-Maximilians-Universität München (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 207000.0 €
Projet PlanetHealth (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Economic Sciences
Statut du projet : TERMINATED

The COVID-19 pandemic is likely the most quickly and widely spreading global crisis of our times. Caused by a nature-borne disease, this crisis is introducing a new level of urgency to the global discussion on sustainability and planetary health as illness and death, economic uncertainty and governmental shut-downs reshape agricultural incentives at the global forest margins. PlanetHealth investigates the effects and mechanisms of the COVID-19 crisis on forest dynamics at the global and local level. It combines a global grid-based dataset (5-by-5 km) of high-frequency spatial data on forest outcomes (losses, fires, fragmentation) with spatialized ex-ante COVID-19 exposure measures. Changes in economic incentives across space are measured with global crop suitability maps, global crop price fluctuations, and geocoded survey data to analyze the labor market mechanisms at play. Their effects on natural habitats are expected to be spatially diverse, depending on bio-physical, economic, and political conditions. A channel analysis highlights the transmission effects along industry types (e.g., tourism, services) and household characteristics (e.g., education, female labor participation). PlanetHealth advances the environmental economics sciences by combining geographical and ecological methodologies with quasi-experimental econometric approaches. Relying on modern shift-share designs will allow for a causal quantification and spatialization of COVID-19 impacts on deforestation. Protecting the worlds’ natural forests becomes increasingly valuable as a strategy to safeguard human well-being and health. PlanetHealth will inform such conservation strategies by investigating the dynamic relationship between health, global shocks, and forest losses. Understanding the heterogeneous pathways will generate valuable information for stakeholders who aim to mitigate the environmental effects of the current pandemic and to identify the strategies for tackling future crises.

Mots clés : environmental economics and policy, agricultural economics, forest conservation, spatial statistics, development economics, natural disasters, pandemics, covid 19, applied econometrics

Participants :
- The University of Texas System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Göttingen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 264669.12 €
Projet CasMETICS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The CRISPR-Cas9 bacterial immune system has garnered intense interest both as a synthetic biology tool and as a biological system in its own right. Yet the ability of Cas9 to find its guide-RNA-directed binding site in a timely fashion remains mysterious. To find its binding site, the single-stranded guide RNA must recognize the appropriate homologous DNA target within double-stranded chromosomal DNA, without using ATP to melt dsDNA. Moreover, in vitro measurements of Cas9 target search seem to suggest that an individual Cas9 molecule should take on the order of months to discover its target site, far too long to defend against viral infections which can proceed to lysis in less than one hour. To begin to unravel these conundrums, I plan to measure Cas9 target search time in vivo, using both single molecule and bulk approaches. The single molecule assay will use fluorescently tagged dCas9 (a version of Cas9 non-functional for cleavage) targeted against the lac O1 binding site. At t=0 the synthetic inducer IPTG can be flowed in, dissociating LacI from the O1 binding site, and the amount of time needed for dCas9 to bind determined by time-lapse fluorescence microscopy. The bulk version of the assay will exploit the existence of a binding site for the restriction enzyme BsrBI in the lacO1 binding site. As in the single molecule assay, the clock is started by addition of IPTG to growing cells, and the time needed for dCas9 binding is quantified by observed how long is needed for dCas9 to confer protection against BsrBI cleavage of cross-linked and purified chromatin. Finally, I will perform high-speed tracking experiments on searching dCas9 molecules using electroporated fluorescent dye-labeled guide RNAs. These measurements should constrain mechanistic hypotheses about Cas9 target search, and may provide insight into other critical biological processes involving single stranded nucleic acids searching in double stranded nucleic acids, such as homologous recombination.

Mots clés : crispr, cas9, single molecule, search kinetics, in vivo

Participants :
- Uppsala University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173857.2 €
Projet CatGTP (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The CatGTP project aims at valorising crude glycerol, which is a by-product of world-scale biodiesel industry. I will develop an innovative one-step catalytic hydrodeoxygenation (HDO) route for upgrading crude glycerol-to-biopropylene (GTP), thus contributing to overcome the challenge of olefins feedstock shortage and diversification in EU. At the University of Lille-ULille (France), I will focus the first part of project on better understanding the surface functions of MoCx≤1@OMS catalysts to assess and tune their HDO properties using a rational design approach backed-up by time-resolved spectroscopy (in situ µRaman and operando NAP-XPS techniques). This part will involve a secondment at the Max Planck Society-MPS (Germany) for elucidating the C-O catalytically active-sites and GTP pathways under near-practice HDO conditions. The second part of project will comprise high-throughput experimentations for quickly determining the main parameters affecting GTP catalytic efficiency (activity, selectivity and long-term stability), and thus, setting the optimisation-intensification bases for the GTP process. The CatGTP’s training objectives are to develop all skills necessary to get established as a full independent scientist within the area of in situ/Operando analyses of catalysed reactions and their optimisation/intensification, and further grow a fruitful collaboration with industry and between these EU labs. Combining the high-level labs-facilities and host/partner supports, I will carry out synergic multi-tasks for successfully achieving the research and training objectives set, thereby, enhancing my professional career prospects in European Union (EU). The exploitation and dissemination of the as-obtained results expect to generate great benefits for the European research Area and industries, as well as, high socio-economical and environmental impacts on the EU society.

Mots clés : crude glycerol to biopropylene, one step hdo reaction, rational catalyst design, time resolved spectroscopy, high throughput gtp optimisation, process intensification

Participants :
- Université de Lille (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196707.84 €
Projet 3-i ICT (Horizon 2020, appel à projets 2020)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

The Centre for Information and Communications Technology Research (CITIC) of the Universidade da Coruña (UDC) is a unique research centre for the promotion of R&D&I excellence in ICT. One of its main aims is to offer specialised technical, research and transferable skills training to early-stage researchers (ESR), including PhD programme studies. 3-i ICT is an innovative new international PhD programme, offering eight fellowship grants to ESRs to carry out their PhD studies at CITIC. The programme will run over 60 months and will include two international calls. Contracts will have a duration of 36 months. The programme will provide ESRs with unique opportunities for basic and applied interdisciplinary research, training and career development. To ensure the 3-i dimension of the fellowship, the programme will include secondments in non-academic partner institutions in Spain and in other countries. To ensure the interdisciplinary nature of the programme, each thesis will have one supervisor from the field of ICT and one from a different academic discipline. The programme will enhance fellows’ career prospects by improving and diversifying their employability skills. They will come away from the programme with a PhD degree and comprehensive complementary training in research and transferable skills. This training will give them a solid competitive advantage in their future careers in both academic and non-academic sectors. 3-i ICT will place CITIC at the forefront of research and innovation in the field of ICT. Institutionally, CITIC is already the leading ICT centre in Galicia, but 3-i ICT will position it as a hub for new research talent in the Galicia-North of Portugal Euroregion. The programme will represent a substantive leap towards accomplishing the goals of the R&I Smart Specialisation Strategy for Galicia (RIS3) and the cross-border R&I Smart Specialisation Strategy of Galicia-Northern Portugal (RIS3T).

Mots clés : interdisciplinary, intersectoral, international, cross sectoral, cross disciplinary, talent, phd programme, employability, excellence, innovation, industry, sustainability, training, skills

Participants :
- University of A Coruña (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 650880.0 €
Projet CHRISTIAN_FRONTIERS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The Christian_Frontiers aims to research the early history of Christianity in the westernmost and easternmost borders of Christendom, that is, in Armenia and Ireland. Neither Armenia, nor Ireland were just the confines of the Roman world, but also the Pax Romana. The aim of this project is to trace early Armenian and Irish Christian identity, to determine how they identified themselves regarding the Roman papacy and how Rome perceived these two remote churches, which were beyond empires. During the work on the Christian_Frontiers not only the history of two national churches will be examined, but also the defending features of Eastern and Western Churches will be explored through the example of Irish and Armenian churches. The history of Irish Christianity has never been researched in comparison to Eastern Christianity, just as Armenian Church has never been considered in context with the Western one. Such a fresh approach in combination with the usage of modern methodology and a wide range of sources, as well as the guidance of an experienced Supervisor will enable the Fellow to provide an original and fresh view on the early medieval history of the countries. To achieve the desired results The Fellow will work in different libraries in Ireland and Armenia to have access to a wide range of sources and references. Consultation-meetings with the supervisors from the Host and Secondment, and other professional trainings, including Latin courses will be undertaken. Apart from professional skills, the Fellow will gain and improve a number of transferable skills by undertaking the trainings organized by UCC. Hence the contribution to the Researcher’s knowledge and career development, creation of wide scientific ties, publications in the relevant peer-reviewed will assist the Researcher in achieving professional maturity and increase her employability.

Mots clés : ireland, armenia, early christianity, roman papacy, christian identity, eastern christianity, western christianity, universal church

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196590.72 €
Projet CoSMaS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The CoSMaS project aims to develop and test an interdisciplinary Collaborative Self-Management Support Model applicable to several chronic health conditions and to validate model measurement tools for use in research and routine care. The proposed research investigates how different HCPs contribute to supporting self-management, how they coordinate care, and how this can be improved to ensure comprehensive (but not redundant) care and ultimately reduce illness burden. It thus addresses recent calls to improve chronic care in Europe, in line with recent advances towards integrated care and current interest in using social science, especially health communication and behaviour change, to inform health services research. Within a 2-year timeline, it proposes a community-based participatory research approach to develop solutions for collaborative care in France in asthma, stroke and cancer based on input from various stakeholders, while also developing the model internationally via collaborations with other EU research centres. Theoretical literature reviews are first planned to inform model development. Qualitative studies are set to explore the views of patients’, caregivers’ and health care professionals of different specialities on current and desired CoSMaS practices. An international Delphi consultation aims to reach consensus on model elements and hypotheses by synthesizing opinions of research and management experts. Self-report tools are developed, piloted and validated in a cross-sectional online survey. This research is linked to relevant training, knowledge transfer and communication activities to broaden the expertise of the researcher, valorize her current knowledge within the host and partner organizations, and disseminate scientific evidence on collaborative self-management support to scientific audiences and the public at large.

Mots clés : health psychology, behavioral science, health communication

Participants :
- Université Claude Bernard - Lyon 1 (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet DELIVER (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks - Industrial Doctorates
Panel : Life Sciences
Statut du projet : CLOSED

The DELIVER EID programme aims to equip 6 industrial PhD graduates with all of the tools required to become creative, entrepreneurial and innovative leaders in the emerging European advanced therapies sector. Advanced therapies are new medicinal products based on genes or cells and tissue engineering products (biomaterials), sometimes used in combination with medical devices. They herald revolutionary treatments for a number of chronic diseases including Alzheimer’s, cancer and the focus of the DELIVER programme, Diabetes Mellitus. We aim to DELIVER the next cohort of translational research scientists in the field of advanced therapies and enabling medical devices for pancreatic islet transplantation, a cell therapy which is poised to become more widespread for the treatment of insulin-dependent diabetes. The DELIVER doctoral training network therefore represents a major interdisciplinary effort between cell biologists, experts in biomaterials, medical devices and advanced drug delivery, clinical experts in islet transplantation and research-active biotech and biomedical companies. Each DELIVER early stage researcher (ESR) will tailor a Personal Career Development Plan (PCDP) to ensure that over the course of the programme the core research skills, advanced research skills and intersectoral transferable skills for a successful career in the advanced therapies sector are acquired. Intersectoral transferable skills training will focus on enhancing career opportunities and employability of the trainees by developing their innovative and entrepreneurial capacity, their communication and leadership skills and their commercial awareness. This will result in graduates with all the skills necessary to innovate, develop and translate advanced therapies for diabetes for the benefit of European patients and industry.

Mots clés : type 1 diabetes, innovation, immune protection, angiogenesis

Participants :
- Explora (Italy) (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 522999.36 €
- University of Tübingen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 505576.8 €
- Boston scientific limited (Irlande) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Boston scientific limited (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Ospedale Niguarda Ca' Granda (Italie) — Partner, organization partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 549368.64 €
- Royal College of Surgeons in Ireland (Irlande) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €