Projet eRaDicate (Horizon Europe, appel à projets 2022)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

The aim of the “eRaDicate” international, multidisciplinary, and intersectoral cancer drug research and development programme is to empower 10 young scientists to become specialists in cancer research and drug development, while developing new therapies against cancer stem cell-driven relapse and metastasis. Nuclear receptors, such as retinoic acid receptor (RAR) and vitamin D receptor (VDR), play key roles in many hallmarks of cancer and constitute effective targets for modern cancer therapy. To address the EU priority “Mission Cancer”, we will 1) test the anti-cancer activity of RAR and VDR targeting compounds; 2) design and synthesise a highly innovative dual action hybrid compound acting simultaneously as RARγ antagonist and VDR agonist; 3) devise pre-formulation strategies for our compounds; 4) and develop a novel, deep learning-based cancer analysis and diagnostics method. We will test how our RAR and VDR-targeting compounds affect stemness and metastatic potential in leukaemia, breast, prostate, colorectal, and ovarian cancer. In parallel, we will assess if the pan-RAR antagonist is effective against chemotherapy-induced neutropenia. For the development of the RAR and VDR targeting compounds into administrable medicines, ready for eventual commercialisation, we will develop pre-formulation strategies. We will generate a novel and highly innovative label-free image analysis method based on histoplasmonic cytometry. The project will have lasting scientific, economic, and societal impact. In order to be prepared for a wide spectrum of career opportunities, we will train the doctoral candidates (DCs) not only to perform original and independent research on an internationally competitive level, but also endow them with creative, critical and entrepreneurial mindset, coupled with persistence in following their objectives. Our consortium consists of 8 academic and 1 industrial beneficiary, as well as 12 associated partners to provide training and secondments.

Mots clés : metastasis, relapse, new chemical entities, genomics, medicinal chemistry, molecular biology, nuclear receptors, preformulation, breast prostate ovarian and colorectal cancer, leukaemia, cytometry

Participants :
- Wannaboo s.r.l. (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Envigo rms bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Trinity College (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 286488.0 €
- Université de médecine de Vienne (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 540662.4 €
- Université Ben Gourion du Néguev (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 271432.8 €
- Selvita s.a. (Pologne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Saint-Jacques-de-Compostelle (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 251971.2 €
- Université de médecine de Varsovie (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 226512.0 €
- Université de technologie du Queensland (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Shaare Zedek Medical Center (Israël) — Partner, associated partner, Autres, subvention : 0.0 €
- Université de Birmingham (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Tissuegnostics gmbh (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 270331.2 €
- Mag. franz tettinger (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université La Trobe (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Varsovie (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 226512.0 €
- Karl Landsteiner University of Health Sciences (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Wrocław (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 453024.0 €
- Physiolution gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Biolution (Austria) (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Danube Private University (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Pikralida sp. z o.o. (Pologne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Janssen (Ireland) (Irlande) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €