Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HYPE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Up to 70% of people will experience a traumatic event in their lives. Following such events, post-traumatic stress disorder (PTSD) emerges as the most common adverse psychological consequence, affecting 10-15% of survivors. Despite available therapies, nearly 40% of patients continue to exhibit hyperarousal symptoms such as irritability, risk-taking behaviors, sleep disturbances, concentration difficulties, and an enhanced startle response. Several cognitive processes (e.g., attentional biases, emotion recognition, executive functioning) have been investigated to understand the mechanisms behind isolated hyperarousal symptoms, such as hypervigilance or startle responses. However, the exact nature and mechanisms through which these cognitive processes influence the whole spectrum of hyperarousal symptoms remain largely unknown. In response, the HYPE project aims to: (1) offer the first comprehensive evaluation of the cognitive processes underlying various hyperarousal symptoms, (2) examine the effects of gender and repeated traumatization on these processes, and (3) longitudinally assess the predictive value of these cognitive processes on the development and persistence of other PTSD symptoms. By utilizing eye-tracking (ET), electroencephalography (EEG) and machine learning techniques, these studies will provide precise and reliable assessments of these intricate cognitive processes and highlight new therapeutic targets with direct benefits for patients. While both the host-lab and myself are specialized in PTSD, the synergy between the host lab's expertise in EEG and affective neurosciences, and my knowledge of ET and advanced statistical methods, makes this ambitious project mutually beneficial. Complementarily, the training activities planned will not only improve my research skills but also my independence, mentoring, and communication abilities, preparing me for a young leader position able to transfer knowledge to both specialized and not-specialized audience.

Mots clés : ptsd, hyperarousal, stress, eye tracking, eeg, attentional biases

Participants :
- Université de Lille (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
- Centre hospitalier régional universitaire de Lille (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet 3MI (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cardiovascular diseases (CVD), particularly myocardial infarction (MI), are partly driven by chronic inflammation, in which myeloid cells, such as monocytes and macrophages, play a central role. This project aims to elucidate the metabolic mechanisms regulating monocyte function and their impact on post-MI recovery. Emerging evidence suggests that the metabolic state of myeloid progenitor cells and their descendants critically influences their pro- or anti-inflammatory functions. While glycolysis dominates early after MI, fatty acid oxidation takes over later stages, indicating that metabolic reprogramming is essential for monocyte and macrophage function.  In this project, we will investigate the metabolic signatures of monocytes at different time points post-MI using a preclinical mouse model and the human HIBISCUS STEMI cohort. We aim to identify key metabolic pathways that can be targeted to modulate inflammation by employing single-cell RNA sequencing and single-cell metabolic assays. In mouse models, we will further test the effects of transiently inhibiting glycolysis or fatty acid oxidation in monocytes, using genetically modified mice, to determine whether this approach improves cardiac function and limits heart failure.  Additionally, the fellowship will provide essential soft skills training in project management, mentoring, and grant writing, which are crucial for my transition to an independent research position. These skills will enhance my leadership abilities and prepare me for future academic and industrial opportunities. This research will provide new insights into the role of metabolism in myelopoiesis and inflammation and could lead to novel therapeutic strategies to improve outcomes in CVD patients.

Mots clés : myocardial infarction, heart failure, monocytes

Participants :
- Hospices civils de Lyon (France) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 242260.56 €
Projet FloR3D (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Nature has optimized the properties of its building blocks by spatially varying hierarchical microstructures within complex form factors. Additive manufacturing techniques, in particular direct ink writing (DIW), are promising pathways towards replicating these systems synthetically, leading to printed materials with tarilored materials properties. However, current DIW techniques do not offer access to out-of-equilibrium materials, greatly limiting printable microstructures. To overcome this limitation, a new DIW technique, termed FloR3D, will be developed in this project. By integrating an evolving chemical reaction into the printing process itself, this Flow-Reactor coupled 3D printing technique allows for out-of-equilibrium microstructures to be generated within the nozzle, which is subsequently trapped upon deposition. Through on-the-fly variations of the relative flow rates into the flow reactor, FloR3D will allow for voxel-level control of the material composition and microstructure, resulting in optimized and spatially-varied hierarchical structures. By incorporating a polymerization-induced microphase separation (PIMS) process, spinodally-decomposed bicontinuous microstructures, which was previously unachievable by DIW, will be printed. Printing these bicontinuous systems, commonly used in nature to exhibit structural coloration, will result in angular-independent structural colored materials with arbitrary form factor. Furthermore, by including photoresponsive monomers within the PIMS system and an in-situ UV source, the materials' refractive indices can be tuned independently of the microstructural feature size, resulting in materials with gradient and spatially-patterned optical properties. Ultimately, beyond the complex photonic materials produced in this proposal, the design of FloR3D can be broadened to incorporate a variety of other chemical reactions, leading to a new pathway towards free-form high-performance materials.

Mots clés : additive manufacturing, structural color, photochemistry

Participants :
- Université de Groningue (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183174.24 €
- Université de Princeton (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet M-Twin4US (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

As buried pipelines face increasing maintenance challenges due to ageing, climate change, and infrastructure deterioration, failures can lead to severe economic losses and public safety risks. The M-Twin4US project aims to develop a novel, maintenance-oriented Digital Twin (DT) platform tailored for buried pipelines, with the flexibility to expand to other underground infrastructure. M-Twin4US will integrate advanced sensing technologies, Ground-Penetrating Radar (GPR) and closed-circuit television (CCTV), with state-of-the-art machine learning methods like Multi-task Transformers and Segment Anything Models (SAM). The project will address critical challenges in soil-pipe interaction analysis, GPR response prediction, and condition assessment by coupling digital modelling, machine learning, numerical modelling (hydro-mechanical and electromagnetic modelling) and real-scale testing. The project will develop a customisable surrogate model to predict future pipeline performance and offer an AI-aided toolkit for stakeholders to prioritise actions such as rehabilitation, excavation, or new construction. The project will be implemented in collaboration with key industry partners and will contribute to transforming underground infrastructure maintenance from a reactive to a proactive paradigm, supporting sustainability, safety, and resilience goals.

Mots clés : underground infrastructure, digital twin, building information modelling, monitoring, maintenance, machine learning, numerical modelling

Participants :
- Université de Durham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 216956.6 €
- Université de Cambridge (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Severn Trent (United Kingdom) (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet CyBRiOx (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Enzyme catalysis is a key technology at the heart of industrial biotechnology, which is expected to drive economic growth and industrial leadership in the EU, while effectively addressing social, environmental and economic needs. Despite the growing impact of biocatalysis, the full potential of this technology has yet to be realized. Major current limitations are: i) only a limited number of chemical reactions are amenable to biocatalysis, and ii) the unique enzymology encoded in the genome of organisms has been minimally explored. CyBRiOx will address this gap by elucidating the role of Rieske oxygenases (RiOx) in the late diversification pathway of indole alkaloids, a fascinating group of compounds with promising biological activities. In doing so, CyBRiOx will not only decipher the complete biosynthesis of these promising drug targets, but in parallel will develop novel RiOx biocatalysts catalyzing much-underdeveloped reaction classes in biocatalysis, namely CoA-independent desaturations and oxidative C-C bond formation reactions. This will be achieved by integrating knowledge of the natural activity of enzymes with bioinformatics, structural biology, enzyme engineering and organic synthesis to develop novel biocatalysts for highly underdeveloped reaction classes. Expanding the scope of existing RiOx offers tremendous potential for a cleaner, more selective, more efficient and therefore cheaper route to various key structural motifs relevant to the industrial and pharmaceutical industries. CyBRiOx will achieve this through the collaboration of the postdoctoral fellow with two leading experts in the field. The MSCA grant will allow the research fellow to further develop his scientific and transferable skills, expand his network, and enhance his overall career prospects and employability to become one of the next generation of leading scientists.

Mots clés : biocatalysis, biotechnology, enzymology, catalysis, rieske oxygenase, indole alkaloids

Participants :
- Université de Groningue (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 272536.32 €
- Université du Michigan (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet DEMyo (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

To meet increasing demands for high-value proteins, broiler selection programs driven by growth rate led to the development of wooden breast (WB), white striping (WS), and novel emerging and unexplored myopathies such as spaghetti meat (SM). In light of the current situation DEMyo project will address important questions in today's myopathies research: is it possible to detect myopathies in birds early age? Are there early differences between animals that will show myopathies at slaughter and the others or not? What’s the difference among animals developing WS, WB and SM? The novelty of the present proposal lies in the innovative application of advanced methodologies based on omics platforms to understand the molecular mechanism involved in the development of broiler myopathies in both sexes. The added value of the project is in assessing if nutritional manipulation with Na-butyrate might be used as a feeding strategy to decreases the occurrence of SM. The project will be developed for 2 years by means of 6 WPs. Candidates diverse scientific background in food science and veterinary medicine and advanced training from BCA and DAFNAE departments (UNIPD) reinforced with secondments at the University of Bologna, Universitat Politecnica de Valencia and Wisconsis-Madison under supervision of the leading experts in the field will maximize the success of the research project and the candidate’s career goals. Communication, dissemination and results exploitation will be addressed to multiple stakeholders by different tools at national, EU and international levels. Results from this multidisciplinary project will have a scientific impact with novel information about myopathies to be adopted in the practice while meeting SDG 1, 3, 5, and 12, improving animal welfare, meat quality, and mitigating economic losses. MSCA project will be a career breakthrough, help the candidate established a position in the field, empower her role as a female scientist and provide her with skills and opportunities for further grants.

Mots clés : broilers, myopathies, omic, next generation sequencing, meat quality, feed, sodium butyrate

Participants :
- Université polytechnique de Valence (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Bologne (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
- A.i.a. agricola italiana alimentare s.p.a. (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université du Michigan (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet NanoplastSorption (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Human exposure to plastics is increasingly recognized as a global environmental threat, primarily due to the invisible and persistent accumulation of its residual content in freshwater sources. While a wealth of studies was still focused on investigating the ecological concerns of microplastics, the highly transformative nature of plastics began to increase the concentrations of nano-sized plastic particles (< 1 µm) in the environment. It is hypothesized that the recalcitrant nature of the nanoplastics facilitates their continuous migration from soil into river systems, leading to their introduction into the food cycle. Indeed, the estimates of nanoplastic leakage from soil to freshwater sources are still considered a missing link in the scientific community. Therefore, there is a high need to establish the mechanisms behind the fate and transport of nanoplastics in freshwater sources by identifying the major hotspots of its accumulation. The research project "NanoplastSorption", is based on the development of carbon-based nanomaterials (CNMs) using lignin as the primary carbon source and polytannic acid as a coating agent. The integration of polytannic acid as a hybridizing material with CNMs enhances their sorption efficiency for both cationic and anionic nanoplastic residues, thereby improving detection potential of CNMs. The study involved an initial assessment of the physicochemical properties and morphological characteristics of aged and unaged nanoplastic particles and subsequently their transport under diverse environmental, hydrological, and biogeochemical conditions. Further, the study utilized fluorescent surface-functionalized CNMs to detect and quantify both aged and unaged nanoplastics particles accumulated in distinct soil and water strata throughout their transport process. This interdisciplinary approach aims to advance the current understanding of nanoplastics by offering robust evidence of their transport and behavior in freshwater ecosystems.

Mots clés : nanoplastics, freshwater, soil, carbon based nanomaterials

Participants :
- Université de Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
- Polymateria limited (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet REDECORATE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Space industry is growing at an unprecedented rate with more satellites launched into low Earth orbits (LEO) each year than ever before. This is leading to an increasing number of collisions of uncontrolled space objects and space debris accumulation in LEO. Sustainability of the space economy requires new techniques to address space debris. REDECORATE proposes CubeSat swarms as a cost-effective way to mitigate space debris. It develops a debris deorbiting and recommission concept combining novel control and guidance approaches and a CubeSat swarm equipped with staged ionic electro spray engines (iESE). A CubeSat swarm can rendezvous with space debris, dissipate its rotational energy (detumble) using reaction wheels. The main thrusters lower the debris orbit to burn-up the system in the atmosphere. Such a mission is highly challenging, requires coordinated CubeSat swarm guidance and control, reliable hardware and effective propulsion - a combination which does not exist so far. First, staged iESE thrusters facilitate longer missions and achieve higher reliability and thrust than standard CubeSat propulsion. If the CubeSats are attached around a decommissioned satellite, coordinated activation of the iESEs can function as a new control system for detumbling (avoiding unreliable reaction wheels), deorbiting and due to their long life-time even recommissioning. Second, a safe-by-design hierarchical control framework will be developed to address the need for high reliability. It uses a planner-tracker feedback stack and addresses all mission segments. Third, integral quadratic constraints (IQCs) will be used to increase robustness w.r.t. system uncertainties and communication delay inside the swarm. The feasibility of the concept will be validated using IQC-based and probabilistic robustness analyses on a digital twin of the iESE CubeSat swarm and microcontrollers-in-the-loop. In summary, the project will provide Europe with know-how to tackle the space debris crisis.

Mots clés : robust control, robust performance analysis, integral quadratic constraints

Participants :
- Université technologique de Dresde (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 289407.84 €
- Institut de technologie du Massachusetts (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université du Michigan (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Waking the Dead (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Waking the Dead examines the problem of the archival gap — the impossibility of knowing much of the lives of the historically ‘unimportant’ — and asks how contemporary fiction imagines these lives anew. For decades, cutting-edge scholarship studying colonialism and its aftermath in Ireland, India and the Black Atlantic have worked on the same problem: if archives, the central object of study in mainstream historiography, only contain the written records of the powerful, then how can historians know anything substantial about the lives of the powerless? My study will expand this field of research by investigating contemporary fiction’s dynamic engagement with the archival gap, and what aesthetic, formal and thematic strategies writers employ to imagine individual lives we can know very little about.  After the 2020 Black Lives Matter protests, the scholarly rekindling of interest in Saidiya Hartman’s concept of ‘Critical Fabulation’ — of imaginative embellishment of sparse archival traces — demonstrates the ongoing importance of these questions. The influential Subaltern Studies school of Indian historiography has read peasant insurgencies as evidence of a collective political consciousness otherwise lost to history. And recently in Irish Studies, there has been an interdisciplinary burst of creative methodologies studying the gender violence of the Magdalen Laundries and the Mother and Baby Homes in the absence of records withheld by the perpetrator institutions themselves. But the right to imagine, to infer, to fill in these gaps is the licence freely given to writers of fiction. This study asks what they do with this licence, and how their dynamic relationship to the archival gap probes at the very limits of historical knowledge. This will be the first interdisciplinary study of contemporary global fiction’s engagement with the archival gap and the first to connect the common projects of ‘recovery’ in Ireland, India and the Black Atlantic.

Mots clés : archival gap, subaltern studies, irish studies, black atlantic, slavery, west african literature, caribbean fiction, magdalen laundries, ireland mother and baby homes

Participants :
- University College Cork (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 426533.76 €
- Université Stanford (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €