Projet CRYSTAL3 (Horizon 2020, appel à projets 2020)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : SIGNED

Cysteinyl leukotrienes (CysLTs) are potent lipid mediators of inflammation. CysLT1 and 2 receptors are widely expressed e.g. lungs, colorectum, heart, brain & eye; and CysLT1 antagonists are prescribed to treat airway inflammation. Excitingly, CysLT signalling was recently discovered to regulate the biology of vascular, neuronal and cancer cells underpinning its untapped therapeutic potential in other diseases. CRYSTAL3 interconnects unique and diverse researchers to create a multidisciplinary team sharing expertise and research capacities. The contribution of CysLT signalling to disease is divulged; its therapeutic potential unlocked and new services & products commercialised. This is delivered by staff exchanges to jointly research Ocular & Central Nervous System (CNS), Cardiovascular system (CV) and Cancer diseases. The R&I goal of CRYSTAL3 is to reduce human disease burden by enhancing EU capability and knowledge-sharing in research and commercialisation. This is achieved through advanced international co-operation between 5 academic and 5 non-academic partners, in 7 countries. The focus is on innovative research into the CysLT signalling pathway in human diseases related to the Ocular-CNS, & CV systems and Cancer (OCCC). The 3 overall objectives of CRYSTAL3 are: A) Combine resources to discover novel pathological mechanisms linking cysteinyl leukotriene signalling to ocular, central nervous system, cardiovascular disease and cancer (OCCC). B) Unite partner capacities to uncover the therapeutic potential of cysteinyl leukotriene signalling in ocular, central nervous system, cardiovascular disease and cancer (OCCC). C) Commercialise products and services co-developed within CRYSTAL3 The CRYSTAL3 consortium tackles these challenges by promoting cross-sector, inter-European R&I staff exchanges among participants with expertise in OCCC disease, computational drug discovery, genetic engineering, pre-clinical disease models, marketing and commercialisation.


Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 115000.0 €
- Cresset biomolecular discovery limited (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 13800.0 €
- Bioreperia ab (Suède) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 9200.0 €
- Universitätsmedizin Göttingen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 27600.0 €
- Ocupharm diagnostics sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 354200.0 €
- Trinity College Dublin (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 128800.0 €
- Regional Government of Andalusia (Espagne) — Partner, beneficiary, Recherche, subvention : 23000.0 €
- Xenopat sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 69000.0 €
- Linköping University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 73600.0 €
- International Iberian Nanotechnology Laboratory (Portugal) — Partner, beneficiary, Recherche, subvention : 23000.0 €
- Experimentica oy (Finlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Pharmahungary 2000 kiserletes es klinikai kutatasfejlesztesi korlatoltfelelossegu tarsasag (Hongrie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 50600.0 €