Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet EuTropRisk (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

During the last 15 years, the eastern North Atlantic has witnessed anomalous tropical cyclones (TCs) generated by the tropical transition (TT) process, some of them affecting or threatening European regions, causing societal damage and public concern. TT is a recently detected TC formation process by which a baroclinically formed extratropical cyclone evolves into a system with a full TC structure. It is also this type of TCs that has the highest likelihood of affecting Europe because they form in midlatitudes. Understanding the TT phenomenon is thus important for weather forecast and informing the public, and researching its link with anthropogenic climate change (ACC) could aid in future mitigation strategy, both with socioeconomical benefits. Recent studies indicated a potential increase of ex-TCs affecting Europe, i.e. of TCs forming via the typical non-TT mechanism and transitioning into extratropical cyclones. However, these studies did not address the TT pathway. Considering the TT process provides a more reliable assessment of the risk of TCs affecting Europe. In addition, newly developed high-resolution global climate models (GCMs) are now potentially capable of simulating TTs. Thus, in order to fill the important knowledge gap about TCs affecting Europe, this project aims to (1) better characterize the development of TTs over the North Atlantic, their predictability and their relationship with midlatitude dynamics, (2) study the representation of TTs in state-of-the-art GCMs, and finally (3) assess the relationship between ACC and TTs, with special focus on Europe. This project is original as it uses new tools and simulations and deals with specific aspects of North Atlantic TCs that have not been addressed before. These aspects are likely highly important for providing the best possible service to society related to weather and climate predictions.

Mots clés : tropical cyclones, climate change, tropical transitions, extratropical cyclones, convection, pv dynamics, global climate modelling, pv streamers

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet PCinBC (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

During the last decade, the ability to treat cancer by targeting the immune system has revolutionized cancer care, but many patients still fail to respond to current immunotherapies, which mainly target T cells. Besides T cells, the tumor microenvironment is home to many other immune cells; however, we are still unable to accurately predict and target the functions of most tumor-infiltrating immune cells, particularly in human cancer. These cells and their tumor-associated functions represent an untapped reservoir of therapeutic targets. Plasma cells (PC), which are antibody-producing cells derived from B cells, frequently infiltrate solid tumors and their presence associates with positive prognosis across cancer types; yet, our knowledge of tumor-infiltrating PC remains limited. The goal of this project is two-fold: first, I aim to use single cell RNA-seq coupled with spatial transcriptomics (developed by the host lab) to define the heterogeneity and spatial distribution of PC (and their subsets) relative to other cells/histological features in patient breast tumors. PC receptor expression and survival factors will be mapped to generate a PC-tumor stroma 'interactome', which should facilitate defining potential vantage points for therapy. Second, I aim to define the cellular age of tumor-infiltrating PC, since knowing how cells are replaced in a tissue could be highly relevant to both uncover fundamental cell turnover mechanisms and to define new therapeutic avenues. The combination of skillsets between the applicant (tumor immunology) and the host lab (spatial transcriptomics and carbon dating, the latter which uniquely can be used to determine cellular lifespan in humans) presents a unique opportunity for the feasibility and knowledge exchange involved in performing this work. This study’s results could help clarify fundamental questions regarding the biology of tumor-infiltrating plasma cells and help uncover novel anticancer therapeutic targets.

Mots clés : tumor immunology, single cell genomics, spatial transcriptomics

Participants :
- Karolinska Institutet (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203852.16 €
Projet BREAKING THE MOULD (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

During the late Bronze Age in Europe (c. 1300-800BC) there was a transition in metal consumption from a restricted-access prestige material to a common medium for making practical objects. The objective of this project is to characterise culturally particular developments in bronze workshop practices using case-study areas in Europe, and through this to rethink relationships linking resource control, craft organisation and identity formation. This is achieved by measuring variability in the technological choices, skillsets and knowhow underlying smithing traditions and defining the social practices of craft production. I will employ a cross-cultural approach using three case studies: the Balkans, Central Europe and Northwest Europe. Multidisciplinary diagnostics will be used to assess technological markers that reveal intentional differences in production techniques. Methods will include 1) collating and analysing metallurgical datasets 2) recording and 3D modelling of craft traces on artefacts, 3) experimental bronze casting and material analysis. I will use these to build the first pan-European metallurgical digital resource, making specialist data more accessible and better enabling international collaborative actions. By moving to UCD, I will work closely with Aidan O’Sullivan, director of the Centre for Experimental Archaeology and Ancient Technology. Resources there and in the School of Archaeology provide a unique constellation for training in bronze object casting, forging and mechanical testing, along with digital 3D rendering of artefacts and data management. My career goal is to be a research leader in experimental archaeology, which this project will enable by developing a novel integrated kinaesthetic and scientific method for the study and visualisation of bronze metalworking. Through training in core and complementary skills, including teaching, supervision, and public outreach, I will develop key resources to maximise the impact of my career restart.

Mots clés : experimental archaeology, experiential archaeology, kinaesthetic, bronze age, archaeometallurgy, metal smith, craft, ancient technology, metalworking, metallurgy, casting

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187866.0 €
Projet ARTFUL (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

During the past century, fossil-based hydrocarbons have been the main source of energy and chemicals, but in addition to be an unsustainable resource, they have led to important environmental concerns such as rising CO2 emissions. The great challenge for our societies is to develop alternative approaches for the sustainable production of energy and materials; the bioconversion of lignocellulosic biomass is one of them. Nevertheless, the physical and chemical recalcitrance of the biomass is the main obstacle to its cost-effective conversion as huge amounts of degrading enzymes are still required. Therefore, a significant improvement in enzymatic degradation is necessary, which involves enlarging the catalytic toolbox. By doing a large scale screening of the secretomes of a substantial fungal collection, the host organisation has shed light on the first member of a new family of lytic polysaccharide mono-oxygenases (LPMOs). LPMOs have been shown to boost the efficiency of cellulases industrial cocktails, thereby greatly reducing the financial and environmental penalties associated with the use of recalcitrant polysaccharides as a feedstock and, moreover, placing LPMOs at the center of considerable research interest. The objective of the ARTFUL project is the functional and structural characterization of the representative members of the new fungal LPMO family. The 6 years’ experience of the French fellow in the glycobiology field (biochemistry, enzymology, structural biology) combined with the expertise of Aix-Marseille University (France) in fungal omics form a solid basis that will be reinforce by the collaborations of experts. The quality of the hosting arrangements will maximise the training opportunities of the fellow and is suited for the two way transfer of knowledge. Acquired generated knowledge will provide a robust functional context to bioinformatic-based predictive biology as well as new enzymatic tools for subsequent industrial applications.

Mots clés : filamentous fungi, plant cell wall, plant biomass, carbohydrates, oxydative enzymes

Participants :
- Aix-Marseille Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173076.0 €
Projet CytoLysoReg (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Dysfunction of lysosomes—the recycling plants of cells, now recognised to participate in multiple aspects of cell physiology—is involved at the onset of several human diseases. Importantly, most of the functions carried out by lysosomes depend on hydrolytic activities within their lumen. Thus, a deeper understanding of the signalling pathways involved in the regulation of lysosomes would provide new tools to ameliorate the symptoms associated with these diseases. The regulation of lysosomal gene expression was partially elucidated by the discovery of the role played by the mTOR-TFEB axis during starvation. However, as recently shown by the researcher (Nature Comm 2018) and others the cytokines-STAT3 axis also contributes to lysosomal regulation. However, the molecular mechanisms of the cytokine-mediated lysosomal regulation still remain unresolved. Thus, the herein proposed project (CytoLysoReg) is aimed at unveiling the molecular and biophysical properties allowing cytokines to regulate lysosomes. CytoLysoReg is an innovative, multidisciplinary project based on international collaborations and preliminary data generated by the researcher during his work as Senior Research Associate at the University of Dundee. The data generated during the execution of CytoLysoReg on lysosomal regulation will allow us to manipulate lysosomes as an approach to treat lysosomal-related diseases (e.g. cancer, LSDs). The role of Prof. Diaz-Quintana as supervisor will be essential, providing his expertise in biophysics and protein structure, and facilitating the integration of the researcher into the host institution (IIQ-Seville). Finally, after finishing the MSCA-IF fellowship, the researcher will be invited to develop his independent scientific career and reinforce the Biological Chemistry line—considered a strategic research line to be developed at the host institute—at the IIQ-Seville thanks to the ongoing MSCA Fellows Stabilisation and Recruitment of Talent Programme of the US.

Mots clés : lysosome regulation, cytokines, cell signalling, phosphoproteomics, metabolomics

Participants :
- Universidad de Sevilla (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet SMAC (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

E-commerce, modern-day government auctions, the sharing economy – these all have in common the optimization of resource allocation through the combination of economics and computation. This trend holds enormous socio-economic opportunity: for example, it allows online auctions, personalized advertising that supports the internet ecosystem, government repacking of radio spectrum to support growing communication needs, and flexible pricing that reflects true demand. It also poses an enormous challenge due to the sophisticated treatment of resources it requires, a challenge which theoretical computer science and algorithmic game theory in particular are uniquely positioned to address. Economists have known for decades that when resource allocation involves complex constraints or preferences, there will be market failures and failed auctions. At the heart of these failures is the presence of complements, which occur when economically-efficient allocation of one resource depends on that of another; in mathematical language this can be described as lack of convexity. Remarkably, this economic phenomenon is closely linked to hardness of computation, which has been extensively studied in theoretical computer science for the past 50 years. The goal of this interdisciplinary research program is to apply the theoretical understanding of non-convexity achieved in computer science, coupled with the flexibility provided by computational markets, in order to design smarter economic mechanisms. As increasingly more resource allocation in our society takes place by interaction with computational mechanisms, a unified computational and economic approach is necessary to prevent market failures and enable the full realization of the potential to boost social welfare.


Participants :
- Hebrew University of Jerusalem (Israël) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 91254.6 €
Projet EDIFOU (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

EDIFOU’s aim is to explore, organize, digitally index and disseminate Michel Foucault’s unpublished manuscripts of the 1950s and the early 1960s on phenomenology, psychology, psychopathology, and anthropology (collected since 2013 at the Bibliothèque Nationale de France Archive). This part of Foucault’s work is still totally unknown today, therefore EDIFOU aims to provide researchers with a new corpus, which is destined to become a reference work in the field of humanities. Together with proposing original theoretical analysis, EDIFOU meets the most current issues of digital humanities especially related to cultural heritage. EDIFOU has indeed the aims to achieve an original editorial program, and generate new knowledge by means of the development of innovative digital tools. As an external scientific consultant of Triangle’s ANR project 'Foucault Reading Notes', I have already tested the usefulness of the digital tools that have been developed in this framework up to now. EDIFOU’s aim is now to contribute to their improvement and further development. EDIFOU is highly stimulating and offers intellectual challenges. It is an ambitious project that requires not only specific scientific competences in the fields of philosophy, social sciences, and digital humanities, but also those personal and practical skills that enable a researcher to work in a team. At this stage of my career, I can rely on an excellent reputation in the international community of scholars in both the fields of Foucault studies, and history and philosophy of psychiatry. The quality of the research environment, supervision, training, and host facilities at Triangle-ENS de Lyon will give me the important opportunity not only to disseminate my research through diverse communication and outreach strategies, but also to profit from those skills, knowledge and training-related measures, which are fundamental to enhance my scientific independence and, as a consequence, my academic status.

Mots clés : michel foucault, edition, phenomenology, psychopathology, anthropology, digital humanities, archive, manuscripts

Participants :
- École normale supérieure de Lyon (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 196707.84 €
Projet EDULIBERA (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Statut du projet : CLOSED

EDULIBERA proposes to study the ‘education as a liberation instrument’ dimension of the independence movements in Mozambique and Timor-Leste, uncovering the histories of encounters and solidarity between the two peoples from 1974 onwards. The objective is to understand how the circulation of ideas and people between these two places could potentially form the base of common principles around education and social emancipation. Also, it will analyse the role of these memories and silenced histories in education and knowledge production today, in the contexts of their post-conflict experiences, and the extent of the fulfilment of the anti-colonial movements imagined futures. In terms of training and career advancement, the objectives will be to broaden the researcher’s expertise and participation in academic networks, consolidate her research profile as one of independence and promote her longer-term integration in the academic profession. As an early career researcher who is returning to Portugal after a period conducting her PhD studies in Australia and fieldwork in Timor-Leste, this will constitute a significant support to her reintegration in the European research community. Benefiting from the supervision of an experienced academic and engagement with a research group at CES, this will improve the researcher’s capacity to produce high-impact publications, take part in international collaborations and conferences, opening new career possibilities. EDULIBERA’s innovative research significance translates into studying alternative knowledges, formed through subaltern historical processes in the global south, opening up space for more critical and democratic views of the world. It is crucial to promote these knowledges about solidarity and dignity that stem from post-conflict and transnational histories at a time when Europe is facing ethnical and religious intolerance and the revival of fascist groups in politics and society.

Mots clés : subaltern histories and epistemologies, africa asia solidarity, education and emancipatory struggles, independence movements, timor leste, mozambique

Participants :
- University of Coimbra (Portugal) — Coordinator, beneficiary, Recherche, subvention : 159815.04 €
Projet EIDOS-IF-2019 (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

EIDOS (EIDOS of a city: simulating the collapse and resilience of ancient Eastern Mediterranean urban environments via agent-based modelling) is an interdisciplinary project that will expand the research communities’ perception about the mechanisms that contributed to the parallel change and transformations of cities in the network of urban habitats of the Eastern Mediterranean. EIDOS will address important questions concerning the phenomenon of urbanization: why do some cities fold at the first sign of turmoil while others, seemingly similar, thrive; what are the dynamic, emergent and complex interactions between growing and deterritorialised (dying) cities within a meshwork of urban environments, from antiquity to early modern times? What components of an ancient city enabled it to be integrated and incorporated into cities of later periods, sometime spanning to our modern period? By combining historical and archaeological data with recent advances in computational simulation methods, EIDOS will significantly add to our understanding about urban resilience in the past. The training and research offered by EIDOS will position the experienced researcher (ER) as an expert in urban computational modelling with highly interdisciplinary methodologies, enabling her to significantly influence urban archaeology and contribute solid foundations to understanding the resilience of our cities.

Mots clés : urban collapse and resilience, agent based modelling, eastern mediterranean, computational methods

Participants :
- Cyprus Institute (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 145941.12 €
Projet ELAMortuary (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

ELAMortuary is an innovative multidisciplinary project combining archaeology, philology and social theory with digital technology to map long timescale social change in the ancient Near Eastern civilisation of Elam through the lens of its mortuary record. It capitalises on a rare opportunity to track developments across pivotal moments in human history through an uninterrupted sequence of mortuary evidence from small village communities (ca. 4500 BCE) to the rise of the Persian Empire (ca. 525 BCE) at a single site, the gargantuan settlement mound of Susa on the Susiana plain, which flanked lower Mesopotamia—the so-called “Cradle of Civilisation”. Its inhabitants travelled along a similar general trajectory to their Mesopotamian neighbours, from villages, to cities, to states, to empires. The project prioritises a longue durée historical view that seeks long-term patterns in societies and it re-evaluates, through a theoretical interrogation of mortuary data, the validity of the still-dominant linear model of social evolution in ancient southwest Iran. In ELAMortuary praxis, theory, acquisition of skills through advanced training, and a strong partnership come together in a high impact project that will generate an open access database with a new set of archaeological and textual data, and a model for analysing it. This timely new approach to archaeological research is now conceivable thanks to the availability of a rich corpus of data, the digital tools to analyse it, and a solid support network of European researchers. ELAMortuary will deliver a body of new evidence that can be exploited by other researchers of ancient Iran and neighbouring regions of the Near East, and it will present a method and case study for assessing long-scale social change through mortuary evidence to the broader archaeological community. Related disciplines and general audiences will benefit from a new contribution to the knowledge base on past human behaviour around death.

Mots clés : elamite civilisation, ancient near eastern mortuary practices, social evolution

Participants :
- University of Naples - L'Orientale (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171473.28 €