Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet FUTURES2020 (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

FUTUREFUTURES 2020 is an ambitious and dynamic programme of events designed to deliver the EU Commission's objectives. A consortium of five universities from across the South West UK have teamed up with world-class venues and heritage attractions to deliver the largest celebration of contemporary research in the region, both in terms of audiences and participating researchers. FUTURES 2020 will reach out to citizens of the large cities of Bristol, Bath, Exeter and Plymouth as well as rural areas of Wiltshire, Somerset and Cornwall. Events will provide direct contact with researchers and showcase the results of contemporary research and its impact on people’s daily lives. We are mounting an ambitions awareness raising campaign, aiming to reach a million people through a variety of methods. We are utilising all our partners' expertise and networks to make this a memorable European Researchers' Night in the last year of H2020. A programme of 23 activities will involve over 300 researchers directly interacting with audiences in innovative and engaging formats. Underpinned by principles of inspiration, invention, inclusivity, fun, learning, and discovery the events will demystify research and innovation, showing their value for individuals and societies locally and globally with celebratory EU Corners at each flagship venue. We have a strong emphasis on engaging school children and families to increase awareness of careers in research and to break stereotypes about researchers. We are also tailoring activities for disadvantaged groups who may not normally have access to research or researchers. Sound management by experienced partners, who have a track record of successful multi-partner projects, with a carefully constructed budget, clarity of roles, significant in-kind contribution from all partners, and an independently conducted evaluation using a mixed methods approach, will ensure that the project is successful in reaching its objectives and good value for money.

Mots clés : futures 2020, south west, bristol, bath, exeter, plymouth

Participants :
- University of Plymouth (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 25470.0 €
- University of Bristol (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 87327.5 €
- University of Bath (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 77695.0 €
- University of Exeter (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 28111.25 €
Projet FUTURES (Horizon 2020, appel à projets 2018)
Action : European Researchers' Night
Statut du projet : CLOSED

FUTURES: Create. Imagine. Explore. will bring together learning from the past and visions of the future by celebrating cultural heritage and exploring innovation. We will achieve this by hosting two nights of activities across the cities of Bristol and Bath engaging the South West region in a celebration and discovery of European cutting-edge research and its place in society. The consortium will be led by the University of Bristol, with the University of Bath as bid partner plus Bath Spa University as a core partner. FUTURES will have a distinctive regional flavour, as we are bringing together Marie Skłodowska-Curie fellows from the Universities of Bristol, Bath, Exeter and Cardiff, and utilising the strong research connections across the West of England and south Wales that exist through the "GW4 Alliance" between these universities. We will also work closely with popular venues such as We The Curious and The Holburne Museum, as well as community spaces such as The Island and Barton Hill Settlement. This range of partners in both cities will ensure a diversity of citizens across the South West region will be able to participate in a range of thought-provoking and inspiring activities engaging them with research. We have a strong emphasis on engaging school children and families to increase awareness of careers in research and to break stereotypes about researchers. We are also aiming activities at specific groups who may not normally have access to research or researchers. For all activities, direct interaction with researchers will allow audiences to engage with the people behind the science. We will provide a coherent story of cultural heritage and innovation that have characterised the region’s scientific and socio-economic development. With Responsible Research and Innovation in mind, working with socially engaged artists we will reflect on how current developments have the potential to influence the future of the region and beyond.


Participants :
- University of Bristol (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 123383.75 €
- University of Bath (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 66675.0 €
Projet EXPECTATION (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Falling raindrops will likely move downwards; red brake lights up ahead will predict a car slowing down. While perception of the world around us feels rich in detail, our brains lack the capacity to analyze every ‘pixel’ at every time-point. Instead, the brain relies on expectations to compress the total amount of sensory information from the environment. A failure to rely on expectations about visual inputs would lead to catastrophic consequences. For example, an air traffic controller without the ability to predict the likely trajectories of two planes coming in for landing would spell certain disaster. Remarkably, despite the obvious role in adaptively guiding behavior, the cognitive and neural mechanisms supporting perceptual expectations remain poorly understood. I will concurrently measure human behavior and neural responses to address two fundamental, yet outstanding questions: How are expectations about visual input acquired, and what is the impact of behavioral relevance? I anticipate mechanisms of expectation to change with learning and behavioral relevance. For example, driving in the rain, expectations about break lights could amplify this immediately relevant information. Expectations about falling rain, on the other hand, could support the equally important task of suppressing this irrelevant information so you may return home safely.

Mots clés : attention, expectation, visual expertise

Participants :
- Radboud University Nijmegen (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260929.8 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet FANCODRUG (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Fanconi anemia (FA) is a genetic disease characterized by bone marrow failure, malformations and cancer predisposition. Currently, there is no cure for FA and life expectancy is 29 years. In addition, FA cells are hypersensitive to DNA coss-linking agents used in chemotherapy making cancer treatment difficult. The genetic cause of FA is heterogeneous, involving at least 19 different FA genes (FANCA, B, C, D1/BRCA2, D2, E, F, G, I, J, L, M, N, O, P, Q, R, S/BRCA1 and T) all interacting in a common DNA repair pathway (the FA/BRCA pathway). FANCD2 ubiquitination and localization at sites of DNA damage is a key step in the activation of the FA pathway and it is used to assess its functionality. Importantly, mutations in FANCA are the most prevalent, accounting for 60-85% of FA cases. FANCA missense mutants mislocalize FANCA to the cytoplasm instead of the nucleus, thereby inactivating the FA pathway. However, FANCA mutants may retain its functionality, suggesting that correction of the subcellular mislocalization of FANCA missense mutants may be an effective way to reactivate the FA/BRCA pathway in these patients. In this application, we propose to conduct a study to develop a system to promote nuclear localization of FANCA missense mutants and evaluate its impact on the activation of the FA/BRCA pathway. This study will yield valuable information about the molecular mechanisms that determine FANCA subcellular localization and pathogenicity of the mutations. In a second part of the project, we will use an unbiased high-throughput approach to screen for drugs that can reactivate the FA/BRCA pathway in cells containing FANCA missense mutations, independently of their mechanism of action. In summary, using a combination of targeted and unbiased approaches, we aim at finding the first drug with the potential to cure FA in a large subset of patients. Personalized medicine-based therapies may be the only option to cure FA and other highly heterogeneous genetic diseases.

Mots clés : fanconi anemia, drug discovery, missense mutations, rare disease

Participants :
- Autonomous University of Barcelona (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 170121.6 €
Projet fORPHAN (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Fast advances in genome sequencing and sequence processing technology leave ~30% of predicted proteins as orphans, meaning without known function or closely related enzymes. Being able to assign a function to such orphans opens avenues to select for and design powerful biocatalysts – individual enzymes, biosynthetic pathways or entire organisms. The herein proposed research aims at developing a de-orphanizing pipeline “fORPHAN” based on computational and experimental characterization of enzymes from the fungal kingdom. Fungi are known to be prolific producers of secondary metabolites, however, the study of the underlying biosynthetic gene clusters is still a fairly young field. The use of automated search and annotation pipelines is currently limited by the small number of experimentally characterized genes and gene clusters that can be used to train the algorithms. Therefore, I propose to use deep targeted database searches to identify key biosynthetic enzymes in the publicly available genomes of fungi. First targets will be the thus-far uncharacterized family of putative chalcone isomerases and the recently discovered family of type III polyketide synthases, which both have great potential for in vivo and in vitro applications. Several gene candidates will be expressed in vitro and in recombinant microbial hosts, and tested for activity on a range of substrates. Interesting candidates will also be characterized by X-ray crystallography. This research will not only yield biotechnologically-relevant catalysts but also provide the bioinformatic foundation for more challenging genome mining projects.

Mots clés : flavonoid biosynthesis, biosynthetic gene clusters, biocatalysis

Participants :
- University of Groningen (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187572.48 €
Projet Female Empowerment (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Female empowerment is perceived both as a policy tool for the betterment of overall welfare of the societies, as well as a policy target both in Europe and throughout the world. However, women still lag behind men in education, economic affluence, and political representation in many countries, even in some of the most “developed” ones. The proposed project aims to shed light on the dynamics behind female empowerment, specifically focusing on the role of urbanization. Modernization and industrialization bring about several advantages for many women such as better education and livelihoods, better say for themselves and their children, and fairer political representation. Yet, urbanization remains insufficient to eradicate the extant problems that women have faced and creates new challenges and obstacles for many. The proposed project argues that female empowerment is a multi-faceted, multi-level phenomenon that calls for such a research strategy and hypothesizes that urbanization has a complex, non-linear effect on female empowerment. To better understand the concept at hand and pinpoint the ways to enhance it, the project incorporates country-, local-, and individual-levels of analysis. The project also combines the strengths of quantitative and qualitative techniques to offer a fuller picture about female empowerment. The main focus of the project is the relationship between urbanization and female empowerment in Turkey, while it also provides a comparative global-level analysis with clear implications for Europe. The proposed research aims to make novel contributions to the feminist studies, urban studies, development studies, and democratization literatures and enhance the competitiveness of European research. In addition to its academic merit, the project also has policy implications aimed at policymakers for future policies and projects, as well as the society at large which could be implemented throughout Europe.

Mots clés : female empowerment, urbanization, modernization

Participants :
- Bilkent University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 157845.6 €
Projet FONTE (Horizon 2020, appel à projets 2017)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

Fibre-optic communication systems form the backbone of the world’s communication infrastructure as they provide for lion fraction (more than 99%) of the global data traffic. The ongoing exponential growth in network traffic, however, is pushing current technology, whose data rates had increased over several decades, towards its limits. It is widely accepted that the nonlinear transmission effects in optical fibre are now a major limiting factor in modern fibre-optic communication systems. Nonlinear properties of the optical fibre medium limit the conventional techniques to increase capacity by simply increasing signal power. Most of the transmission technologies utilized today have been originally developed for linear (wired or wireless) communication channels. Over the past several decades, significant improvements in data rates were obtained by improvements and modifications within the overall linear transmission paradigm. However, there is much evidence that this trend is going to end within the next decade due to fibre nonlinearity. There is a clear need for radically different approaches to the coding, transmission, and processing of information that take the nonlinear properties of the optical fibre into account. This also requires education and training of a new generation of optical communication engineers and specialists with knowledge on nonlinear methods and techniques. The EID FONTE R&D goals will be focused on development of disruptive nonlinear techniques and approaches to fibre-optic communications beyond the limits of current technology. The project will make important innovative steps in development of the technique of the nonlinear Fourier transform (NFT) and its implementation in the practical communication systems. The R&D tasks will be carried out along with training of PhD students in the leading research centres in Europe with industry focused projects with 50% of time spent in the world leading telecom centre - Nokia Bell Labs Germany.

Mots clés : fibre optic communications, optical networks, high capacity transmission, nonlinear signal processing, nonlinear transmission impairments

Participants :
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- Technical University of Denmark (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 290081.88 €
- Institut Mines-Télécom (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262875.6 €
- Nokia (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Delft University of Technology (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255374.28 €
Projet FictDial (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

FictDial investigates the function and processing of dialogue in literary fiction in exchange with what we know about real-world conversational dialogue and, thereby, aims to bridge a gap between the current psycholinguistic and neuroscientific knowledge of verbal interactions (conversations) and literary research. Its starting point is the suggestion that reading literary fiction can augment our capacity for social inference and empathy. The project aims to understand 1) what could be learned from fictional (literary) dialogues about every day social interactions (objective 1), 2) how fictional dialogues are processed (objective 2) and 3) how these dialogues affect the knowledge of adults and adolescents about real-life social interactions (objective 3). It applies methods from different disciplines from qualitative, literary analysis to behavioral experiments and measurements of eye-movements. Fictional dialogues are studied with special attention to gender-specific ways of verbal interactions, and mechanisms of social learning are examined in relation to embodied experiences and immersion during reading. The project is hosted by the Norwegian Reading Centre, with a secondment at the University of Oslo, involving experts from education, empirical reading research, narratology and cognitive science. The proposed project includes activities of dissemination and communication to the academic sector but also to teachers, pupils, and policy makers. The research, training and publication activities of the project will enable me to enhance my profile as an independent researcher.

Mots clés : dialogue, empirical methods, interdisciplinarity, literary reading, immersion, embodiment, social learning

Participants :
- University of Stavanger (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €
Projet EBUCAI (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Financial liberalization and cross-border banking underpin a striking global trend: while creditor countries had net financial claims on debtors of 20% of GDP in 1980, by 2010 this had risen to 70%. In accounting terms, such international wealth re-distribution materializes via current account (CA) surpluses by creditors and deficits by debtors. Hence the interest in what drives such CA imbalances, their desirability, and sustainability. The recent Eurozone crisis brought further attention to the issue: Greece, Ireland, Portugal, and Spain all had unprecedented CA deficits in the run up to the crisis, and studies indicate that such high deficits helped trigger it. The MAIN OBJECTIVE of this project is to deepen understanding of the links between CA imbalances, cross-border banking and credit. Much of CA flows consist of purchase/sale of debt contracts between residents and foreigners, and since up to two thirds go through banks, the accounting link is clear. Unclear is the behavioral link: What motivates such flows and makes them very risky at times? This project’s novelty is to build a model of this behavioral link, focusing on the Eurozone. This main objective WILL BE ACHIEVED BY: - A new general equilibrium model featuring international risk-taking banks with potential externalities on the economy and which can amplify CA imbalances - A new database on banking indicators and macro-determinants of CAs - Model estimates using O2 and state-of-the-art empirical methods - Assessment of risk thresholds and welfare of regulatory policies - Scenarios for intra-Eurozone imbalances under the EU banking union This research is HIGHLY RELEVANT TO THE WORK PROGRAM because unexplained CAs expose countries to undetected risks, and studies on Eurozone CAs do not model bank behavior thus overlooking a main component of imbalances. This research is timely because growing cross-border banking affects imbalances and understanding such links is key to EU banking union policies.

Mots clés : current account imbalances, financial sector linkages, banking union

Participants :
- Institut für Höhere Studien - Institute for Advanced Studies (IHS) (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166156.8 €
Projet EU4HIVCURE (Horizon 2020, appel à projets 2015)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : CLOSED

Finding a CURE for 35 Million individuals living with HIV/AIDS is one of the great global health challenges of the 21st century. The major obstacle to HIV eradication is the persistence of latent HIV cellular reservoirs, where the integrated viral genome is transcriptionally silenced but replication-competent and can escape both Anti-Retroviral Therapy and Immune Responses. The development of novel strategies aimed at eliminating these reservoirs have become paramount in HIV research, if we want to achieve an HIV/AIDS CURE. To accelerate the State of the Art in HIV CURE research in Europe, our EU4HIVCURE consortium brings together an intersectoral and interdisciplinary collaboration between 3 Universities, 3 Hospitals, 1 International Research Organisation from 4 European countries and 1 University from Canada. Our aim is to dissect the intricate mechanisms controlling HIV-1 latency and identify new druggable targets to develop novel latency-reversing strategies and eradicate persistent viral reservoirs by forcing HIV-1 gene expression. To facilitate continuum for translation to the clinic, we have developed an operational framework, which maximises exchange of knowledge and expertise via secondements, networking and training activities.

Mots clés : hiv post integration latency, hiv persistent reservoirs, hiv cure, translational research, preclinical studies, new classes of latency reversing agents, innovative hiv reactivation strategy

Participants :
- Mater Misericordiae University Hospital (Irlande) — Partner, beneficiary, Autres, subvention : 0.0 €
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 108000.0 €
- Université Libre de Bruxelles (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 81000.0 €
- Université de Strasbourg (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 121500.0 €
- International Centre for Genetic Engineering and Biotechnology (Italie) — Partner, beneficiary, Recherche, subvention : 0.0 €
- Centre Hospitalier Universitaire de Saint-Pierre (Belgique) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université de Montréal (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €