Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ObSerVation (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Infrastructure systems such as bridges and critical buildings are integral to modern society and play a decisive role in a nation’s economic, social, and strategic stability. Considering Europe’s aging infrastructure, much of it exposed to significant seismic hazard and maintained under constrained budgets, effective and science-driven integrity management solutions are urgently needed. Structural Health Monitoring (SHM) systems can enhance decision-making by reducing uncertainties in both structural capacity and seismic demand. This project will develop an advanced, updatable Decision Support Tool (DST) for the optimal design and implementation of SHM systems for structures and portfolios in seismic-prone regions. The DST will build on the Value of Information (VoI) framework, integrating enhanced models of structural capacity that account for both gradual deterioration and sudden seismic damage, as well as mainshock-aftershock-aware seismic demand models. A novel stochastic ground-motion generator, informed by 3D physics-based simulations and calibrated to regional recordings, will capture source, path, and site effects while explicitly addressing aftershock-specific spectral characteristics and period elongation in damaged structures. Calibration and validation will leverage the unique datasets of the Seismic Observatory of Structures (OSS) within Italy’s Department of Civil Protection, which provides dense, multi-typology, real-time recordings of both ground motion and structural response. By combining advanced deterioration modelling, aftershock-aware hazard representation, and operational OSS datasets, the project will establish a maintainable, continuously updatable DST framework. This approach advances the state of the art in post-earthquake risk assessment, supports resilience-driven prioritization of interventions, and demonstrates tangible societal benefit by reducing economic losses, infrastructure downtime, and environmental impact. The results will directly contribute to European disaster resilience goals and to the United Nations’ Sustainable Development Goals by strengthening the science-policy-practice interface in seismic risk management.

Mots clés : value of information, structural health monitoring, integrity management, 3d physics based simulation, bridge

Participants :
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215937.6 €
- Civil Protection Department (Italie) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université de l'Illinois (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ADVCATALNANOMAT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The ADVCATALNANOMAT project covers one important topic “the decarbonization of the energy sector” as the core for a sustainable economy. In this direction, the synthesis of methanol and higher alcohols from CO2 and renewable H2 is considered, aiming to increase process efficiency in order to accelerate the deployment of CO2 based technologies. To achieve this, the specific objectives of the project are: i) the design of new catalytic systems based on non-layered 2D metal oxides through topochemical transformation using ultrathin layer double hydroxides (LDH) precursors, ii) optimize the reaction conditions through kinetic studies, iii) establish a relationship between structure and activity to achieve a better understanding of the nature of the active site and its reaction mechanism, supported by mathematical models and theoretical studies, and iv) test and evaluate the performance of catalysts at semi-industrial scale, bridging the gap from the laboratory to a pilot plant. Innovative materials, with particular surface properties that relates to the coordination number of metal cations, defect sites, high surface area and high metal dispersion will be prepared targeting high alcohol selectivity (C1-C5) in the hydrogenation of CO2. In this direction, multifunctional catalysts containing Cu (for non-dissociative C-O bond activation), Ni (for dissociative C-O activation), and Co (for C-C coupling) will be explored. The success of this proposal lies in the interaction of several disciplines, including material science, the use of advanced spectroscopic characterization tools including Synchrotron Light Radiation tools, chemical engineering and theoretical simulation. All these will support the proposed research and provide the necessary knowledge for the design of new catalysts. It is a very ambitious project with significant scientific, social and environmental impact, contributing to strength the know-how in the field of catalyst design and CO2 valorization.

Mots clés : co2 hydrogenation, synthesis of nanomaterials

Participants :
- Clariant (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut de technologie de l'Illinois (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université polytechnique de Valence (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 226441.2 €
- ALBA Synchrotron (Spain) (Espagne) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet p53-REACT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The project proposal aims to engineer a bacterial host to produce variants of secondary metabolite resveratrol and address the interrelationship between dynamics, structure and function of a system of high medical interest, the tumor suppressor protein p53. The study considers to elucidate the mode of action of these molecules against the p53 mutants and work on new concepts for cancer therapy. Inside the cell, the folding of a protein is a fast and robust process. Sometimes, however, sudden changes in the balance between different existing forces result in incorrect folding of the peptide chain, which ends up generating amyloid aggregates within the cell that lead to the gain of toxic function, since these aggregates can conduct to death of the cell in question. Most amyloidogenic pathologies are neurodegenerative, however the aggregation also plays an important role in cancer. The project provides a broad framework for the study of the resveratrol derivatives acting as p53 aggregation inhibitors by using cutting-edge tools of computational resources, metabolic engineering and structural biology. But could, in principal, be applied to exploit the chemical diversity of other biocompounds similarly intending to act as less cytotoxic agents in a more effective antineoplastic therapy, which represents one of the major existing scientific gaps. It is a proposal on a very important topic that will be studied from a unique perspective.

Mots clés : molecular interactions bioinformatics p53 reactivation, resveratrol

Participants :
- Université technique de Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
- Rensselaer Polytechnic Institute (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PETRI (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Due to its multidrug resistance (MDR), Enterococcus faecium (Efm) poses a challenge to the healthcare system and renders most standard antibiotics useless. Bacteriophage (phage) therapy has resurfaced as a treatment strategy for bacterial infections due to increasing antibiotic resistance. Its advantages include specificity, low side effects and production costs, especially when used in combination with standard-of-care antibiotics. Phage therapy has been successful in compassionate use, but its wider implementation is hindered by a lack of knowledge on which antibiotics phages synergize and the mechanisms behind remain elusive. Our project is unique in that it aims to enable the use of conventional antibiotics in MDR Efm through phages. We want to explore which antibiotic classes phages synergize with, which survival strategies Efm uses against phages, and how host factors influence the ability of the antibiotic-phage combination to kill Efm. First, we will investigate phages' interaction with different antibiotic classes against Efm. We will explore the dynamics of phage-antibiotic combinations and whether they are additive, synergistic, or antagonistic. Second, potential phage survival strategies of Efm will be investigated. Additionally, membrane vesicles will be investigated as a potential survival strategy against phages, and their ability to act as a decoy and protect the bacterium from phages will be studied. Third, we will investigate the impact of host factors on the phage-antibiotic killing of Efm, to see whether they can enhance or suppress the phage-antibiotic killing. This approach will provide a deeper understanding of the phages-antibiotic interaction against MDR Efm strains, as well as potential survival systems of Efm which may also shed light on possible mitigation strategies. Overall, this approach has the potential to enable the use of standard-of-care drugs against MDR bacterial infections in general.

Mots clés : phages, multi drug resistant, enterococcus faecium, antibiotics

Participants :
- Université de Tromsø (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 307939.68 €
- Université du Colorado (system) (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet iTRACH (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Tracheal damage is often life-threatening, and its incidence has increased due to invasive mechanical intubation of COVID-19 patients. Short defects undergo a surgical procedure (anastomosis), but this is not feasible for extensive defects. While bioengineered approaches for such defects have been investigated, there has been little translation into the clinic as implants weaken over time and fail to support the formation of neotracheal tissues. I aim to solve this problem by developing and characterising 3D printed tubular scaffolds for use as medical devices for tracheal restoration via a Global Fellowship involving Royal College of Surgeons in Ireland and Boston University, followed by a non-academic placement in CellInk. Scaffolds will be designed to mimic tracheal biomechanics and will be extensively characterised. Induced pluripotent stem cells (iPSCs) will be used to develop a pre-vascularised mature respiratory epithelium on disc scaffolds in combination with endothelial progenitors and human mesenchymal stem cells (hMSCs). The tri-culture will then be moved into the tubular design and the pre-vascularised mucosal substitute will be grown and assessed in vitro as an approach for ex vivo seeding of tracheal grafts prior to implantation. The ability of the tubular scaffold to support the growth of cartilage tissues will be assessed using a combination of bioprinting and differentiation of hMSCs. iTRACH will provide me with crucial training in advanced research skills (iPSCs, stem cell biology, biomaterials & 3D printing) and transferrable skills (Intellectual Property, Project Management, Entrepreneurship, Professional Enhancement and Science Communication). This fellowship will provide me with the required technical and complementary skills to enhance my employability and to allow me to transition into a research position in a leading biomedical company, while also allowing for the possibility of me staying in an academic role with links to industry.

Mots clés : trachea, 3d printing, airway progenitors, hydrogels, vascularisation, cartilage, bioreactor, bioprinting, airway regeneration, induced pluripotent stem cells, medical device, respiratory epithelium

Participants :
- Cellink bioprinting ab (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 328494.96 €
- Boston University (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ReNa (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This research proposal aims at rethinking a collective and proactive concept of responsibility towards nature and future generations, on the basis of the understanding of nature developed by German Idealism in the early 19th century and the theory of responsibility first advanced by Hans Jonas in the 20th century. I will articulate my research into two steps, which aim at two objectives: 1) I will first work on the rational foundation of collective proactive responsibility towards the world in which we live, that is the duty to take care of it. This is the “objective side” of my research, in the sense that it grounds on a consideration of human beings as rational and responsible agents in themselves, in a Kantian sense. To reach this first objective (which is the most challenging one), a further step is needed: the elaboration of a concept of nature and its relation to human being able to take into account (1.1) the ontological continuity between nature and human being and with this the value of nature and life in themselves; (1.2) the primary responsibility of humans. All this will be possible analyzing and revitalizing the concept of nature in German Idealism and studying its ethical implications. 2) Second, I will investigate the role of human motivation, the context and the consequences of human action as essential part of any theory of responsibility. This is the “subjective side” of my research, that aims at providing the “bridge” between the formal foundation of the concept of collective responsibility and its application. In this part, my research will deal with the key concepts of “respect”, “care” towards vulnerable nature and future human beings, and “fear” of a collapse of nature and our future lives. The concept of collective responsibility generated by this project might show its fertility also with reference to contemporary debates (like those related to environmental issues).

Mots clés : german idealism, responsibility, nature, georg wilhelm friedrich hegel, hans jonas

Participants :
- Université de Vérone (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 288859.2 €
- Université Friedrich-Schiller d'Iéna (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Boston University (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PSC-ZB (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Self-powered integrated solar rechargeable batteries are becoming a safe and practical solution for power backup in remote areas, disaster zones and inconsistent sunlight regions. The high indoor energy conversion efficiency perovskite solar cells (PSCs) and non-explosive quasi-solid zinc batteries (ZBs) are promising options for next generation energy conversion and storage devices. Novel ZBs offer high-energy, leak-proof safety, cost-effectiveness, and environmental friendliness, making them superior to the explosive Li-ion batteries (LiBs). Solar rechargeable ZBs (PSC-ZB) can effectively generate and store solar energy in a two-electrode battery, simplifying the design and minimising external energy loss. However, several major challenges hinder the mass adoption of PSC-ZB: (i) low efficient common photoactive cathode, and (ii) destabilisation and short cycle life caused by side reactions on Zn anode. Firstly, the proposal involves a initiated chemical vapor deposition (iCVD) process to develop compact, fully lead-closed PSC-ZB with a cathode via bifunctional heterojunction concept (BCH). This design incorporates a safe-by-design self-power supply unit that enables immediate storage of solar-to-electrochemical energy. The MXene-encapsulated cathode, developed using the Stöber method, and the dendrite-free anode, improved with Na+ electrolyte additives and protective coatings can significantly enhance the cycling stability and energy efficiency of PSC-ZBs. The main goal of PSC-ZB is to boost efficiency (>12%) and stability by increasing active sites, shortening diffusion pathways, and enhancing anode plating and stripping cycles. Achieving PSC-ZB goals would advance state-of-the-art direct solar-to-electrochemical batteries in a simple two-electrode format, crucial for meeting EU environmental targets for a cost-effective and eco-friendly energy system. This fellowship offers an excellent opportunity to achieve long-term career goals and expand my knowledge.

Mots clés : solar batteries, perovskite solar cells, zinc ion batteries, 2d mxenes, st ber process, initiated chemical vapor deposition icvd

Participants :
- Catalan Institute of Nanoscience and Nanotechnology (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université Christian Albrecht de Kiel (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 217965.12 €
Projet RESTORE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Visual working memory (VWM) is the cognitive process responsible for temporarily maintaining in mind visual information that is no longer in view. The neural architecture of VWM has been of continuous scientific interest and it has been proposed that the sensory visual cortex is involved in the brain network responsible for successful REpresentation STOragE during VWM. However, the contribution of the sensory visual cortex in VWM remains a subject of intense debate, underscoring the need for a decisive investigation. RESTORE aims to shed light on this debate. Through a three-way transfer of knowledge, RESTORE will lead to contemporary methodology, by combining transcranial magnetic stimulation (TMS) with electroencephalography (EEG), resulting in a robust and cost-effective approach for studying VWM. By combining TMS with EEG, RESTORE will surmount the limitations of previous work (e.g., the correlational nature of brain-imaging studies, the lack of evidence for neural activity in brain-stimulation studies) and thus result in causal evidence for the role of the sensory visual cortex during VWM. This scientific leap will not only resolve a longstanding controversy but also introduce an efficient approach for conducting neuroscientific research, hence contributing to the literature and advancing the current state-of-the-art. In addition, RESTORE will enhance the expertise repertoire of the researcher and the participating organisations. In turn, this will establish a strong foundation for pursuing ambitious and innovative research in the future, as well as provide knowledge and skills for training future researchers in contemporary research. RESTORE's innovative integration of TMS and EEG aims to decisively illuminate the longstanding debate about the role of the sensory visual cortex in VWM and lays a solid groundwork for future ambitious investigations, while fostering expertise and knowledge transfer for the next generation of researchers.

Mots clés : visual working memory sensory recruitment transcranial magnetic stimulation visual short term memory

Participants :
- Institut de technologie de Chypre (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252968.16 €
- Nevada System of Higher Education (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PLASMARISE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The PLASMARISE project aims to pioneer the application of cold plasma technology (CP) for wastewater treatment to address two global challenges: Water security and antibiotic resistance. Using dielectric barrier discharge (DBD) CP technology, the project will develop a technology to efficiently remove pathogens and antibiotic resistance genes (ARGs) from wastewater, enabling safe water reuse and reducing pollution. PLASMARISE follows a hypothesis-driven approach and comprises five scientific work packages (WPs): 1) Construction of a DBD-CP reactor; 2) Performance evaluation of the DBD-CP generator. Experiments will evaluate the effectiveness of the generator in inactivating pathogens and degrading ARGs under different conditions; 3) Evaluation of DBD-CP in collected treated wastewater samples; 4) Investigation of the effects of DBD-CP treatment on leakage of mobile genetic elements (MGEs): The release of MGEs into treated water will be investigated; and 4) Techno-economic analysis and roadmap for technology deployment: A comprehensive study will assess the economic viability and scalability of the CP -based technology, leading to a technology deployment roadmap and business plan. PLASMARISE offers a novel, interdisciplinary approach that pushes the boundaries of CP technology by integrating it with wastewater treatment. This innovation could revolutionise the water cycle and contribute to water security worldwide. By addressing pathogens in water and ARGs, PLASMARISE is also tackling the critical problem of antibiotic resistance, which impacts both public health and the environment. The results of the project will have broad application, from domestic sanitation to industrial processes, paving the way for more resilient and sustainable water management.

Mots clés : cold plasma wastewater environmental biotechnology

Participants :
- National Laboratory of Health, Environment and Food (Slovénie) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université nouvelle de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 176375.88 €
- Université de Ljubljana (Slovénie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Trovant technology sl (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €