Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MaReLand (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

MaReLand is an interdisciplinary project and ethnographic study of land reclamation along the Malaysian littoral. Reclamation is the act of creating new land and artificial islands from the sea. The approach that the state and developers are taking is reminiscent of neo-colonial and neoliberal conceptions of the mare nullius (‘nobody’s sea’), an empty space to be transformed by large-scale construction projects. Many are concerned about the socio-ecological effects for the environment and coastal communities. On the one hand, reclaimed landscapes are being planned for the development of high-tech fantasies of a luxurious lifestyle in a greener and smarter environment. On the other hand, such projects are intended to transform spaces that nevertheless represent enduring heritage such as fisheries, seascapes and biodiversity. Reclaimed landscapes thus emerge as contested spaces where what is not considered heritage becomes attractive for development. MaReLand explores the competing discourses of sustainability and cultural heritage held by a variety of actors. Situated at the intersection of urban anthropology and critical heritage studies, the project will examine two under-researched themes: a) environmental activism and the critique of heritage hierarchies, and b) the study of urbanization at sea. Through ethnographic research in two field sites, interviews and the organization of co-design activities with local stakeholders, the project seeks 1) to advance empirical knowledge on practices related to the right to the city/right to the sea, and the ways environmental activism and discourses on sustainability and heritage conservation unfold on the ground; 2) to advance theoretical knowledge on the masterplans and compensation policies at work around yet-to-be-built-islands; and 3) to develop a Toolkit that disseminates solutions to conflicts over land reclamation, by using ethnographic evidence to reshape policy-oriented practices in land reclamation.

Mots clés : critical heritage studies, urban anthropology, land reclamation, environmental activism, sustainability, malaysia, southeast asia

Participants :
- Université Palacký (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 150438.72 €
Projet SURPLAS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The management and disposal of plastic waste is an ever increasing problem with the EU alone generating more than 29.1 million tons of post-consumer plastic waste each year. The main aim of the proposed project is to deliver an integrated solution utilizing plastic waste to generate low carbon H2 and low carbon liquid fuels providing a decarbonisation route for the stationary power generation and transport sectors toward a clean energy and sustainable future. Thus, SURPLAS is in line with the European Union's Strategy for Plastics in a Circular Economy and serves the ultimate goal of the recently announced Green Deal toward an energy transition to a low or even zero carbon economy to effectively combat climate change. In specific, different types of plastic waste will be processed, characterized and gasified to produce syngas at high hydrogen yields with adjusted H2/CO ratios and low tar formation, employing optimum operating parameters and catalysts to improve the gasification performance. At the same time, SURPLAS is proceeding one step forward with the conversion of gasification derived syngas mixtures toward Fischer-Tropsch (FT) liquid synthetic fuels using advanced in terms of synthesis and composition nanocatalysts. Thus, regarding the FT synthesis process, SURPLAS is aiming to optimize process conditions and identify superior catalysts to enhance the activity and selectivity of FT process to diesel and gasoline fractions (low carbon fuels) for maritime and heavy duty vehicles applications. The final objective of the proposed project is to elaborate reliable energetic and feasibility studies for real-scale SURPLAS processes (kW and MW scales) and to investigate their potential market prospects and business cases.

Mots clés : waste plastics energy recovery gasification syngas fischer tropsch synthetic liquid fuels low carbon transportation fuels heterogeneous catalysis process systems design feasibility study

Participants :
- Centre for Research and Technology Hellas (Grèce) — Coordinator, beneficiary, Recherche, subvention : 169326.72 €
Projet EPIMemory (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

In this research project I seek to discover the mechanisms underlying oral epithelial cell (OEC) memory and its importance to control Candida albicans infections and commensalism. C. albicans is part of the healthy microbiota, but it is also the most clinically relevant fungus. Fine tuning of mucosal immunity enables homeostasis and regulates commensal-to-pathogen transition of C. albicans. Innate immune cells, such as macrophages, can develop long-term responses during systemic infections, enabling them to clear invading microbes more efficiently. This so-called process of “innate immune memory” can be targeted in order to improve patient outcomes. However, at the oral mucosa, where immune cells are more scarce, OECs are essential for controlling fungal growth and orchestrating complex immune responses. Whilst OEC-C. albicans interactions have been well analysed during acute infections, no study up to date has addressed epithelial memory or its impact on fighting fungal infections and regulating Candida commensalism. The aim of this project is to understand the molecular and cellular mechanisms driving epithelial memory in response to C. albicans. In preliminary in vitro studies, I have shown that epithelial memory protects OECs from C. albicans and therefore, I hypothesised that this phenomenon control fungal growth during pathogenesis and homeostasis. I will use advanced models of host-microbe interactions to confirm the importance of epithelial memory for clearing infections and whether it promotes fungal commensalism by regulating microbial growth. I will decipher the underlying molecular mechanisms by analysing gene expression and metabolic profiles of memory cells, and identify potential targets that promote homeostasis at the oral mucosa. This project will yield novel insights into mucosal fungal immunology, essential knowledge to further comprehend how out body interacts with the microbiota and to identify targets to advance in the treatment of candidiasis.

Mots clés : epithelial memory, innate immune memory, epithelial cells, fungal immunology, immunometabolism, host microbe interactions, microbial metabolism

Participants :
- Center for Cooperative Research in Biosciences (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet RTR (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In an era of increasing international migration, understanding cultural dimensions is crucial for fostering mutual understanding and social cohesion. Roots to Routes (RTR) is a participatory action research on the West African Atlantic Route that investigates cultural representations and practices of migrants from West Africa to the Canary Islands, with a focus on food as a conveyor of identity and a ground for cultural encounter. Research on irregular migration to the Canary Islands has emphasized economic and political aspects, understating cultural elements. RTR addresses this gap by exploring cultural practices, especially food-related ones. Its objectives are: 1) gathering information through field research; 2) promoting participatory actions to involve local communities; 3) creating visual documentation; and 4) offering policy recommendations for the European reception system.  RTR employs a multi-sited ethnographic approach, engaging migrants, local communities, and NGOs in Senegal, Southern Morocco, and the Canary Islands. This strategy allows for a nuanced examination of migrants' experiences and cultural transformations before and after their journey to Europe. Participatory actions include workshops and events centered on food and cultural exchange, while the visual component involves collecting and creating images and videos for dissemination. By examining the maintenance and transformation of cultural identity and food habits during migration, RTR offers insights into social integration dynamics and contributes to culturally informed policies, aligning with key EU migration and cultural diversity objectives.  The project is timely given the ongoing humanitarian crisis associated with the Atlantic Route. RTR's innovative approach positions it to make significant contributions to both academic discourse and policy development in migration studies, ultimately fostering mutual cultural knowledge and promoting positive intercultural interactions.


Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €
Projet MultNT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

This project concerns multiplicative number theory and its interplay with the emerging topic of additive combinatorics. Multiplicative number theory is an area of number theory concerned with the study of prime numbers and multiplicative functions. One of the most important unsolved questions in this area and in all of number theory is the twin prime conjecture, asserting that there are infinitely many pairs of prime numbers differing by two. In 1965, Chowla formulated an influential conjecture that can be viewed as an approximation to the twin prime conjecture. Chowla’s conjecture predicts that the prime factorisations of consecutive integers behave independently of each other. This conjecture captures the key difficulty in the twin prime conjecture, but yet there has been a lot of recent progress on Chowla’s conjecture by the applicant and others. The aim of this project is to make substantial progress on Chowla’s conjecture, as well as on other key questions in multiplicative number theory, using a mixture of methods from analytic number theory and additive combinatorics, as well as higher order Fourier analysis, a theory recently developed by Green and Tao. Connections between Chowla’s conjecture and questions in additive combinatorics and higher order Fourier analysis have recently been discovered in works of the applicant and others, and the proposed research aims at exploiting these connections to make substantial progress on Chowla’s conjecture. The project also involves several other problems of interest in number theory, such as the Hardy—Littlewood conjecture on average and the Hasse principle for almost all surfaces of a certain type.

Mots clés : analytic number theory, multiplicative number theory, additive combinatorics, exponential sums, sieve methods, rational points

Participants :
- Université de Turku (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet ALERT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Acute Myeloid Leukemia (AML) results from the uncontrolled expansion of differentiation-defective hematopoietic stem/progenitor cells or immature myeloid cells (blasts) in the bone marrow (BM). AML remains a high-risk disease mainly due to treatment refractoriness which is dependent on leukemia-BM stroma interactions. Unfortunately, treatments have only experienced minor developments over the last decades. On the other hand, emerging evidence in cancer metabolism has identified Lipid Droplets (LDs, cytosolic fat storage organelles) as key regulators of lipid metabolism and signalling in cells exposed to stress such as hypoxia, chemotherapy, and nutrient deprivation. However, the precise role of LDs in the pathogenesis and chemoresistance of AML remains poorly investigated. Here, we aim to i) characterize the accumulation and role of LDs in AML, ii) assess the functional impact of blasts- and BM stroma-LDs on AML pathogenesis and chemoresistance, and iii) investigate the involvement of LDs in the progression and refractoriness of AML. Cutting-edge in vitro (AML primary cells, BM-stroma cells) and in vivo assays (patient-derived xenografts) will be used to provide evidence of LDs as a key player in leukemogenesis. Our project is based on solid preliminary single cell-RNA sequencing data indicating that LDs are highly accumulated in AML blasts, and that inhibition of LDs is more effective than the standard-of-care chemotherapy in impairing AML cell proliferation. Our proposal represents an innovative approach achievable thanks to the complementary knowledge and expertise of two top-notch laboratories in acute leukemia (supervisor) and LDs (collaborator). Results from this study will open new avenues to explore the therapeutic opportunity of LD inhibitors as anti-leukemic co-adjuvant. This fellowship will enable me to acquire transformational knowledge in leukemia metabolism and will constitute a major first step towards initiating my independent academic career.

Mots clés : lipid droplets acute myeloid leukemia chemoresistance perilipins

Participants :
- Onechain immunotherapeutics s.l. (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Fundación Josep Carreras Contra la Leucemia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 226441.2 €
Projet ChroMet (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The initiation and maintenance of leukaemia are often regulated through the interaction of epigenetic mechanisms and metabolism, but how these affect each other, is not always fully understood. One of the epigenetic mechanisms that alter cell fate is the replacement of replication-coupled histones with non-canonical variants. MacroH2A (mH2A) variants (mH2A1.1, mH2A1.2 and mH2A2) have a large, metabolite-binding macrodomain and differ from each other solely in the structure of their ligand-binding pocket. Of those three, only mH2A1.1 has known ligands, while the binding partner and corresponding biological functions of mH2A1.2, are still unknown. The preliminary data suggest phospholipid molecules as unique ligands of mH2A1.2. At the same time, they show that the MACROH2A1 is required for the maintenance of the stemness of leukaemia stem cells and leukaemia itself. During the ChroMet project, by using cutting-edge techniques in cell and molecular biology, computational biology and biochemistry, I aim i) to confirm the identity of putative ligands of mH2A1.2 and to biophysically characterize the binding interaction, and ii) to test the contribution of the newly identified metabolite-binding capacity of mH2A1.2 on the leukemia cell differentiation and tumorigenicity. The findings of the project will allow me to describe the mH2A1.2 as an entirely novel metabolic sensor on chromatin, which, through the binding of phospholipid ligands, regulates cell metabolism and impacts leukaemia cell fate. The complementary knowledge and expertise of the hosting group (in epigenetics and metabolism), the hosting institute and long-standing collaborators (in leukemia research), and my own (in biochemical analyses of protein-ligand interactions) will ensure the successful realization of the proposed project and contribute to the development of my career as an independent researcher, committed to exploring an interplay between epigenetics, metabolism and cancer.

Mots clés : histone variants, phospholipid metabolites, acute myeloid leukemia, leukemia stem cells

Participants :
- Fundación Josep Carreras Contra la Leucemia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet FICTA SciO (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The research will identify and raise awareness about the audiovisual conventions and communication tactics of animation in multimedia science outreach, in respect to the representation of invisible objects (too big, too small, too far away in space and time).  The research is in the field of animated documentary, a major point in the Animation Studies agenda (Honess Roe, 2013). It is also based on the epistemology of scientific communication; as Daston and Galison argued (2007), «truth-to-nature» objectivity is being superseded by visuals balancing art and science. Merleau-Ponty (1964) had previously called for an equilibrium between objectivity and subjectivity in science outreach, due to the new “invisible” frontiers of knowledge. The action will start with 12 months at the Lucerne University of Applied Sciences and Arts, whose excellence in visual research and its interdisciplinary environment will support the Researcher in: 1) building a list of animations in multimedia science outreach from 1980; 2) critically engaging the conventions and tactics from the point of view of animation theory, 3) of animators and 4) of scientists (in dialogue with the resident experts on data visualization).  The next 12 months will be hosted by the Department of Cultural Heritage of the University of Padova, Italy. With the collaboration of the Department of Information Engineering and the CICAP (the Italian committee for scientific skepticism), the results from the outgoing phase will be used to: a) create an open access database of multimedia science outreach about the “invisible”; b) set up educational actions; c) create a permanent committee to promote good practices in animation for science.  The Researcher will take advantage of his expertise in animation history and theory, his contacts with the industry and with animation schools, and his teaching experience. The research will consolidate his career and make him a mediator between academia, scientists, and filmmakers.

Mots clés : animation science outreach

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 207609.6 €
- Haute École de Lucerne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Cicap - comitato italiano per il controllo delle affermazioni sulle pseudoscienze - aps (Italie) — Partner, associated partner, Autres, subvention : 0.0 €
Projet INNOSHEAL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Electrochemical water splitting (WS) to produce hydrogen has been recognized as an up-and-coming technology for storing zero-carbon electricity generated from intermittent and non-dispatchable renewable energy sources. Among water electrolyzers, the emerging anion exchange membrane water electrolyzers (AEMWEs) are the most promising, combining efficiency and sustainability. Although it is an attractive technology, it is not yet mature and needs to be further improved to meet market needs. One of the main bottlenecks is related to the efficiency and durability of the WS catalysts. In this context, INNOSHEAL project (INNOvative Self-HEALing chalcogenide catalysts for green hydrogen production) aims to develop new WS catalysts, free of critical raw materials (CRM-free), highly efficient, and durable thank to self-healing groundbreaking properties. The innovative strategy is based on developing a design that allows for a large number of Fe-, Ni- and Mo-based catalytic active sites and an auxiliary system that promotes material self-healing due to the presence of a subnanometric layer of chalcogenide (S-, Se-, Te -based) sites. To ensure the successful achievement of project goals, the project will be conducted at ICB-CSIC, the Spanish National Research Council, with operando investigation during a secondment at PSI in Switzerland. The expected results of this proposal will primarily concern new knowledge on catalytic properties and self-healing characteristics, together with a contribution to the reduction of hydrogen production costs and the elimination of CRM dependency. The resilience of hydrogen-integrated energy systems is crucial for a reliable energy transition in Europe and will consolidate Europe's leadership in this field. Moreover, this project will help the researcher to enhance her academic profile and research skills, offering exciting career prospects while promoting new collaborations.

Mots clés : green hydrogen, anion exchange membrane water electrolyzer, critical raw material free catalysts, hydrogen evolution reaction, oxygen evolution reaction, 2d dichalcogenides

Participants :
- Institut Paul Scherrer (Suisse) — Partner, associated partner, Recherche, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €
Projet FruitAGPs (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

By 2050, the global population is projected to reach approximately 9.7 billion, adding significant pressure on the world's food production systems. This global population increase will require a substantial improve in food supply, including fruits, which are essential for human nutrition. To understand the fundamental molecular mechanisms related to the fruit development is extremely important for increasing crop productivity and high-quality fruit and seed production. Furthermore, the knowledge acquired in this process will be important for developing fruit crops resilient to changing climates, meeting this demand sustainably and ensuring food security. FruitAGPs aims to provide new insights into the role of Arabinogalactan Proteins (AGPs), cell wall glycoproteins crucial for plant growth and development, and their putative transcriptional regulation in fruit tissues providing crucial knowledge about their functions in these tissues. This will be achieved using a combination of cutting edge genetic, proteomic and molecular biology approaches in Arabidopsis thaliana. Both the host laboratory and researcher stand to benefit from FruitAGPs, as it bridges two distinct molecular research fields focused on the same developmental process: fruit development.

Mots clés : arabidopsis arabinogalactan proteins fruit development transcription factors

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €