Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ClimSHIFT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Climate change is driving significant shifts in species distributions globally, yet our ability to predict these changes remains limited. Only 47% of assessed species are moving towards cooler regions as expected, while others have remained static or shifted towards warmer areas. This variability poses a critical challenge for biodiversity conservation. The ClimSHIFT project aims to revolutionise our understanding of species' climate-driven range shifts by applying state-of-the-art mechanistic niche models across a large dataset of over 1000 bird species. We will address three key research objectives: WP1) Identify biological traits influencing species' adaptability to changing climates. WP2) Assess if species are tracking previously unrealised climatic tolerances, by developing accurate predictive models based on species' fundamental climate tolerances. WP3) Generate improved forecasts of future avian biodiversity patterns, highlighting periods and areas of synchronised range contractions and ecological disruption. This project represents the first such global-scale assessment of distribution response to climate change using species' fundamental physiological limits to predict range shifts. By combining cutting-edge methodologies with an extensive dataset, ClimSHIFT aims to significantly advance our ability to forecast and mitigate climate change impacts on biodiversity. Our findings will have far-reaching implications for conservation planning and ecosystem management. We will provide essential information for targeted conservation efforts by identifying vulnerable species and potential future habitats. The novel frameworks developed can be adapted to other taxa, providing a more comprehensive understanding of ecosystem responses to global change. Ultimately, ClimSHIFT seeks to transform our approach to biodiversity conservation in a rapidly changing world, providing the scientific foundation needed to safeguard species and ecosystems for future generations.

Mots clés : predictability, climate change, birds

Participants :
- Université de Picardie Jules Verne (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University College de Londres (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet IMPROVE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

IMPROVE aims to demonstrate the potentiality of Transurethral Shear Wave Viscoelastic Elastography (TUSWAVE) for ‘improving’ the diagnosis of Prostate Cancer (PCa) by identifying it through a new set of biomarkers based on the fractional viscoelastic properties of the prostate. TUSWAVE is a novel concept based on the transmission and reception of shear waves in the prostate through the urethra. Most prostatic tumours are stiffer than normal surrounding tissue, which perturbs the propagation of shear waves. The perturbed waves carry information about the location and changes in the viscoelastic properties of the tumours. IMPROVE aims to further study the correlation between diagnosis features of prostate cancer, such as grade, stage and vascularisation, with shear fractional viscoelastic properties of the prostate, i.e. the shear modulus, the shear viscosity and the fractional-order parameter. To achieve IMPROVE’s goal three main work packages are proposed. First, the development of a 3D anatomically realistic wave propagation model validated in ex vivo human prostate; second, the characterisation of the fractional viscoelastic properties of prostatic tissue under different pathological conditions using Shear Wave Elastography and validated against independent techniques; and finally, the development of a preliminary Artificial Intelligence-based image reconstruction method for TUSWAVE. A large database of prostate cancer clinical scenarios will be generated using the data from the characterisation study and the 3D wave propagation model. This database will be used to train and test the image reconstruction method. Prostate-like phantoms will be used to test the performance of the image reconstruction method. IMPROVE will take TUSWAVE towards a pre-clinical studies stage. IMPROVE is aligned with the mission area 'cancer' set on Horizon Europe.

Mots clés : elastography prostate cancer viscoelasticity biomarker medical imaging reconstruction

Participants :
- Université de Grenade (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
- University College de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Flexi-Zinc (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Developing on-chip planar micro-batteries with high-capacity, environmentally safe, cost-effective, and stable electrodes is essential for powering future miniaturized systems-on-chip smart devices. Planar-type device configurations, where electrodes are organized in an interdigitated electrodes (IDEs) pattern on the same substrate, provide several advantages over traditional sandwich types, such as controllable internal resistance and ionic diffusion distance, without a separator. These configurations reduce battery size and facilitate seamless integration with on-chip microelectronic devices. However, processing on-chip planar micro-batteries presents challenges, particularly in patterning metal IDEs current collectors using lithography techniques and loading active materials using traditional electrodeposition methods. These processes can hinder the direct printing of micro-batteries onto on-chip sensors, especially biomedical or related flexible sensors, making the realization of a systems-on-a-chip approach difficult. This project focuses on designing fully printed flexible on-chip planar zinc-ion micro-batteries (Planar-ZIMBs) using advanced Microplotter techniques. Printing the cathode and anode on metal-free exfoliated graphene current collectors eliminates complicated lithography and allows direct printing of Planar-ZIMBs with on-chip microelectronics. The innovation lies in exploring high-capacity manganese vanadium cathode and zinc anode materials without compromising material properties and integrating with a lithium-free compatible gel electrolyte, enabling micro-battery processing in environmentally friendly conditions and reducing overall processing costs. This new and innovative approach to developing micro-batteries is a critical advancement for the evolution of advanced miniaturized systems-on-chip smart devices.

Mots clés : planar zinc ion micro battery, interdigitated microbattery, smart electronics, transition metal oxide cathode, flexible battery

Participants :
- University College de Londres (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet UNWANTED (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The EU is facing difficulties in her attempt to promote interdependence and peace in a context of geopolitical collision. Indirect intervention in external areas has produced unwanted effects. My research aims to investigate the unplanned consequences of external interventions by great powers using historical examples to provide insights for contemporary strategies. Modernity was built upon unplanned effects of strategic interference during the final clash among Atlantic empires, in the global Age of Revolutions. Intrusion in the Hispanic world allowed Britain to speculate on American coin and bullion to finance its Foreign Aid to Spain and Europe against Napoleon. By following Irish trans-imperial agents managing these speculations, the project looks at how global trade involving Latin America and changes in silver and gold flows transformed Britain's economic role with implications in Europe and worldwide. It links these financial initiatives to the best possible business in a revolutionary context, the arms trade. For the first time it shows how revolution in Spanish America ended up providing economic means to liberate Spain from French occupation through British aid and then to finance the struggle of other European nations against Napoleon, with the crash of the old imperial systems as an unwanted effect. This greatly accelerated the rush towards modern economy and empires. Through rigorous archival evidence this ambitious project aspires to kindle a deep-seated awareness of the past and present mechanisms and possible management of the unplanned revolutionary impact of strategic intrusion. Investigation in Spain(UPO) Mexico(UNAM) and the UK(UCL) and DEC activities like the creation of a DoNoSQL database, OA publications(3), conferences(3), syllabus, political brief, videos, cooperation between historians and political scientists(Side-NET) will help turn the tide of the present erosion of rule-based international relations as an unwanted effect of interference

Mots clés : napoleonic wars, british foreign aid, silver and gold flows, irish diaspora, global trade, trans imperial mediators, imperial agents, age of revolutions

Participants :
- Archivo histórico provincial de cádiz (Espagne) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université nationale autonome du Mexique (Mexique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Pablo de Olavide (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 236153.88 €
- University College de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet CYCLER (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The remarkable increase of plastic production in recent decades poses many harmful impacts on the environment and people’s health. CYCLER aims to build up a fundamental understanding of the chemistry involved in chemical recycling processes of solid plastic waste (SPW) by: 1) developing robust theoretical protocols for solution/melted phase determination of chemistry models parameters (i.e. kinetic rate constants of elementary reaction, thermodynamic and transport properties) and by 2) developing a priori semi-detailed chemical kinetic model for different polymers representative of SPW streams. Ultimately this project, by providing high-accuracy kinetic models, supports the industrial-scale implementation of thermochemical conversion technologies towards a circular approach to SPW management.  To achieve the goals, CYCLER will exploit the combination of various approaches including the quantum chemical, molecular dynamics and metadynamics methods. The calculation will be performed for pure plastic polymers typically found in SPW streams (i.e. polyethylene, poly methyl methacrylate, polyamide and polystyrene) so as to cover a large set of chemical functionalities. Detailed information on the chemical reactivity, the possible reaction pathways, and knowledge of the free energy hypersurface will be assessed to derive systematic structure/reactivity relationships.  CYCLER drives a step-change advance in the state of art of solution phase computational chemistry, applied chemical kinetics and chemical reaction engineering by proposing a novel theoretical kinetic framework that, coupled with semi-detailed chemistry models, allow fundamental chemical understanding and thus optimization of process conditions at the industrial level. The advanced knowledge in the chemical recycling of SPW, academic networks, and the transferable skills acquired from the MSCA PF will enormously support me in fulfilling my career goal, to be an independent researcher.

Mots clés : solid plastic waste, kinetic modeling

Participants :
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- Université de Gand (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University College de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PlasmonKITE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Achieving critical EU goals of ubiquitous carbon neutrality and a smooth green energy transition requires the development of highly efficient and low-cost photovoltaic technology. Perovskite solar cells are the most exciting recent breakthrough in renewable energy technology due to their low cost, ease of manufacture, and high efficiency. However, the most promising perovskite compositions, such as PbSn, are plagued by low light harvesting efficiency. Optically active nanoparticles, such as gold and silver, have been investigated to increase the light absorption of PbSn perovskite, but are chemically unstable and expensive. To address this pressing concern, PlasmonKITE proposes the computational and experimental coupling of abundant, optically active, and highly stable nanoparticles to lightweight and flexible all-perovskite tandem solar devices, enhancing their light harvesting ability and achieving next-generation solar cells with broad applications. Photophysical modeling will be employed to determine the optimal nanoparticle geometries to maximize the light harvesting enhancement within the surrounding perovskite material. Then, the specified nanoparticles will be synthesized and embedded in perovskite films which will be tested for stability and photoconversion efficiency. Finally, model perovskite devices will be used as building blocks to build tandem all-perovskite solar cells which absorb efficiently across the visible and near-IR spectrum. The realization of this new technology is theorized to achieve unprecedented performance at a lower cost than conventional silicon photovoltaics, accelerating the green energy transition.


Participants :
- Université de Stuttgart (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Séville (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €
Projet REPCO2 (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The increasing levels of atmospheric carbon dioxide call for urgent solutions to reduce greenhouse gas emissions and support the shift toward a sustainable energy economy. REPCO2 (Renewable Electricity-Powered Plasma-Catalysis for CO2 Revalorization Process) is an interdisciplinary project that aims to develop new technology for CO2 valorization by creating innovative atmospheric pressure plasma configurations, exploring low-cost, environmentally friendly, and stable catalysts, and utilizing advanced in situ characterization under plasma conditions. Traditional thermal CO2 conversion methods typically require high temperatures and expensive catalysts, often containing precious metals. In contrast, non thermal plasma-catalysis offers a more energy-efficient and versatile alternative, operating under ambient conditions, such as room temperature and atmospheric pressure. In this way, inert molecules are activated by the plasma under mild conditions, and the resulting reactive species selectively recombine on the catalyst surface to form the desired products, thereby enhancing both chemical and energy yields. Rational design of catalysts tailored to the plasma environment, based on deep insights into the underlying mechanisms, is of particular interest as a novel approach. This requires fundamental studies to understand the potential synergy between plasma and catalyst. By optimizing the contributions of both plasma and catalysts, REPCO2 aims to increase reaction yields and promote the industrial application of atmospheric pressure plasma technology. The candidate will synthesize copper-based catalysts supported on zeolites. These plasma-catalyst systems will improve plasma-induced CO2 hydrogenation and dry reforming of methane (DRM) due to enhanced diffusion of reactants and plasma species, which may also prevent catalyst deactivation. Additionally, the cost-effectiveness of the synthesized systems will boost their potential for commercial applications.

Mots clés : non thermal plasma catalysis, co2 valorization, zeolites, synergy, tailored catalyst synthesis, in situ characterization

Participants :
- Université de Séville (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209914.56 €
Projet FlaviRNA-HMT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Neurotropic flaviviruses Zika virus (ZIKV) and tick-borne encephalitis (TBEV) represent major emerging arthropod-borne viruses transmitted by two different vectors, either mosquitoes or ticks. In humans, they use cells of the immune system to spread throughout the organism and can lead to severe encephalitis. During their replication, viruses produce double-stranded RNA (dsRNA) structures which is not only a necessary by-product but also performs key regulatory functions and acts as a pathogen-associated molecular pattern recognized by the host innate immune response. However, viral adaptation to such divergent host cells and organisms and their immune response, especially in arthropods, is poorly understood. In this project, I propose to investigate and compare how neurotropic flaviviruses interact through their RNA in humans and arthropods. First, I will identify host factors involved in protein-dsRNA complexes using anti-dsRNA antibodies in a high-throughput proteomic approach from infected live arthropods and human models for immune and neuronal cells and compare the protein networks between each host. Second, I will select the most significant and relevant hits for a functional screening, further define the function of the best candidates that are either pro-viral or anti-viral, confirm their importance in most relevant models and characterize the molecular functions of the best candidates. Finally, I will identify the dsRNA structures and RNA species interacting with the best candidates, and determine the evolutionary pressure imposed on the viral genomes in each host. Altogether, this project will contribute to unravel the adaptation of neurotropic flaviviruses to their hosts throughout their cycles, both from a mechanistic and evolutionary perspective, help understand the role of the RNA in crossing species barriers and lay the grounds for new therapeutics and disease control strategies against viruses that represent an ever-increasing threat in Europe.

Mots clés : encephalitis, neurotropic, flavivirus, arthropods, vector, ticks, mosquitoes, immune response, neurons, pathogen associated molecular patterns, rna sensing, rna immunity, rna interactomics

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 208410.88 €
Projet GREENMULTIDIMCO2 (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Chemical characterization is essential to the study of bioactive compounds in natural and biological samples but conventional preparative and analytical techniques are usually time, energy and solvent-intensive, posing environmental and health risks. Supercritical carbon dioxide (CO2) present an eco-friendly alternative due to its interesting physio-chemical properties. Prof. West’s research group has been developing approaches involving supercritical CO2 for two decades, and recently developed an integrated system combining supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) for the on-line extraction and analysis of polar and non-polar bioactive compounds from plants. Although feasible, such coupling is very challenging, especially when targeting compounds with a wide range of polarities. The next step is thus to further improve the developed system and explore its applicability to other samples with different matrices and classes of compounds. Specifically, the use of unified chromatography (UC), an advanced version of SFC, will be investigated to further expand the efficiency and potential scope of the system. Since the interfacing of the two techniques is a major bottleneck preventing the system from reaching its full potential, finding innovative solutions to facilitate the extract transfer from the first to the second dimension is necessary. An important part of this project will thus be devoted to investigating new interface modalities to address the compatibility problems and instrumental issues pertaining to this hyphenation. To boost chromatographic separation power and facilitate structural elucidation, the potential of incorporating multidimensional (mD) separation steps while coupling the system with mass spectrometry (MS) will also be explored, to develop a novel on-line (mD-SFE)-(mD-SFC/UC)-MS system. Finally, the system’s utility will be demonstrated through qualitative and quantitative analyses of real-life samples.

Mots clés : multidimensional chromatography hyphenated techniques bioactive molecules extraction methods green chemistry natural products biofluids

Participants :
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université d'Orléans (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 301660.8 €
- Université de Lund (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Kyūshū (Japon) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €