Projet LightDyNAmics (Horizon 2020, appel à projets 2017)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : CLOSED

Light interaction with biomaterials is the driving mechanism of fundamental biological processes, from photosynthesis to DNA photodamage, and is a powerful tool in biomedicine for analytical, diagnostic and therapeutic purposes. The main goal of LightDyNAmics is to achieve a complete understanding of the ultrafast dynamical processes at the molecular scale induced by UV light absorption in DNA, and to unveil the mechanisms leading to photodamage of the genetic code. At the same time, our project will transfer this knowledge on light-matter interaction to a broad class of optoelectronic materials, highly relevant for Europe`s high-tech industries. LightDyNAmics is an academia-industry research environment training 15 Early Stage Researchers (ESRs) by crossing the traditional border between theoretical and experimental expertise. This will be achieved by performing independent, yet interrelated and complementary research projects focussed on photoactivated dynamics of DNA, and by developing a variety of new spectroscopic and computational methods. For all the ESRs, personalised training in advanced techniques will be combined with a broad common interdisciplinary background on dynamical processes in bio-macromolecules. The consortium brings together 10 leading academic groups with multidisciplinary expertise (chemistry, physics, biology) and a unique blend of experimental and computational skills. 6 innovative companies, from SMEs specialised in click-chemistry and in biosensors to a pharma industry, will be fully integrated in the research and training programme and help promote technological exploitation of its results. LightDyNAmics will develop innovative molecular probes for DNA/protein interaction, paving the way to new diagnostic tools and new drugs. The understanding of light interaction with organic molecules will impact on basic sciences, from biochemistry to nanosciences, and on industrial applications ranging from healthcare to photonic technologies.

Mots clés : molecular and nonadiabatic dynamics, photophysics, excited electronic states, charge transfer, excitons, nucleobases, guanine quadruplexes, pump probe and 2d spectroscopy, computational spectroscopy

Participants :
- University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255934.08 €
- Politecnico di Milano (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- Prigen srl (Italie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- National Research Council (Italie) — Coordinator, beneficiary, Recherche, subvention : 516122.64 €
- Ludwig-Maximilians-Universität München (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 498432.96 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 262875.6 €
- Masaryk University (Rép. Tchèque) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 232422.48 €
- Baseclick gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- E 4 computer engineering spa (Italie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Accelopment (Switzerland) (Suisse) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Durham University (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- AstraZeneca (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 273287.88 €
- Molecular discovery ltd (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Dynamic biosensors gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- National Institute of Chemistry (Slovénie) — Partner, beneficiary, Recherche, subvention : 234997.56 €
- National University of Ireland (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 265674.6 €
- University of Bologna (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €