Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ACORN-PURM (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

ACORN-PURM (AC) develops a next-generation upper-limb rehabilitation system that leverages adaptive control of soft robots and ML to provide personalized therapy based on individual patient needs, significantly improving user engagement and recovery outcomes. Stroke, spinal cord injuries, and other neurological conditions cause upper-limb disabilities, affecting millions globally and leave them with impairment. It creates a significant burden on healthcare systems. Current rehabilitation approaches often lack personalization, leading to decreased motivation and suboptimal outcomes. AC addresses this critical gap by developing an innovative solution that is: more engaging, data-driven, and patient-specific system that tailors therapy to individual needs, enhancing patient engagement and potentially accelerating recovery. The system has the following unique features: Gamified exercises enhance motivation and adherence to therapy schedules, real-time adjustments based on user intent and fatigue levels optimize therapeutic benefit, soft robotics ensure patient comfort and safety during rehabilitation sessions. Existing robot-assisted therapies are often rigid, uncomfortable, and lack real-time adjustments based on individual progress, offering one-size-fits-all approaches. Relying heavily on subjective therapist evaluations for progress tracking can be repetitive and tedious, leading to patient dropout and possess limited ability to anticipate user intentions. AC advances the field by 1) Developing Adaptive Controllers with ML that will adjust assistance levels based on individual real-time data for a truly personalized experience, 2) Utilizing DL for Advanced Movement Recognition and Assessment to analyze user data for objective assessment of subtle improvements and compensation strategies, 3) Creating gamified therapy with ML Integration to have engaging games that dynamically adjust difficulty and target specific user needs, promoting long-term engagement.

Mots clés : rehabilitation, neurorehabilitation, physical medicine, physiotherapy, semg, electromyography

Participants :
- MAR Health Park (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Rovira i Virgili (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209914.56 €
Projet CR-EVOL (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The modern human head and neck are very different from those of great apes, both from a morphological and postural point of view. However, differences in the cranio-cervical complex are also observed compared with our closest extinct ancestors, the Neandertals. But did morphological differences between modern humans and Neandertals have a biomechanical impact on their posture? Understanding the relationship between the head and neck from a broad evolutionary form and function perspective is crucial to ultimately resolving this question. CR-EVOL objective is to address the co-evolution of the cranium and cervical spine in the Neandertal lineage and determine to what extent biomechanical factors related to posture influenced this evolutionary process. The curvature and morphology of the neck have changed during human evolution. The sparse and incomplete fossil record suggests that differences in the cervical spine within the genus Homo are related to differences in the cranial shape. Moreover, it has been proposed that different hominin groups, including those from the NEA lineage, "solved" the requirements of erect posture in different ways. Thus, to directly test this question, the ER will receive training-through-research in key cutting-edge techniques and fundamental knowledge for his future as a researcher in palaeoanthropology: Phylogenetics (Beneficiary), Biomechanics (Secondment), and Hominin fossil record (Short visits). Also, the ER will be supervised and trained in broader aspects of academic activity, knowledge transfer, and career development, enabling him to position himself as a potential research leader.

Mots clés : palaeoanthropology, human evolution, biomechanics, integration, 3d imaging, european pleistocene hominins

Participants :
- Muséum national d'histoire naturelle (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
- Université Rovira i Virgili (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MANGO (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

There is a lack of knowledge on the multitude of chemicals that we are exposed to, and even less is known about the exposure during pregnancy, the most critical window for adverse health effects on both mother and offspring. In turn, the prevalence of Gestational Diabetes Mellitus (GDM) has incredibly increased during the last decades and it is now diagnosed in up to 18% of the pregnancies. In this context, I propose the project “The Chemical Exposome of Pregnant Women with Gestational Diabetes Mellitus (MANGO)” to be co-supervised by Dr. Navas-Acien and Prof. Gary Miller at Columbia Mailman School of Public Health (USA, Third Country for the outgoing phase), and by Prof. Domingo at Universitat Rovira i Virgili (URV, Spain, beneficiary institution and host for the incoming phase). The main scientific goals of MANGO are: (1) to determine the occurrence of non-target chemicals in biological samples of 400 pregnant women; (2) to evaluate the association between the exposure to chemicals and clinical data, exploring the effect modification by sociodemographic, dietary and lifestyle factors; (3) to implement a pilot prevention programme to minimize the exposure to hazardous chemicals during pregnancy. These objectives will be tackled by integrating last advances in high-resolution mass spectrometry (WP1), mathematical models (WP2) and risk assessment and prevention strategies (WP3). MANGO will leverage biological samples of Diabetes and Pregnancy Cohort from Institut d’Investigació Sanitària Pere Virgili/Hospital Universitari Joan XXIII (IISPV/HJXXIII, associated partner) and will return the knowledge to Europe by implementing the first pilot programme to increase the awareness of the exposure to hazardous chemicals. Through this MSCA-PF-GF, my training in environmental epidemiology in USA would capitalize upon my skills on non-target chemical analysis (MSCA cofund in INSULIN Tecniospring), facilitating the start of a new research line and a track-tenure at URV

Mots clés : exposome, gestational diabetes mellitus, pregnancy, adverse health outcome, endocrine disruptor

Participants :
- Université Columbia (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- CERCA Institution (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université Rovira i Virgili (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 261380.64 €
Projet MOSAIC (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : TERMINATED

Organic conjugated materials (OCMs) possess unique electronic properties compared with other traditional semiconductor materials, due to the delocalization and high polarizability of π-electrons supporting the motion of charge carriers, as well as their significant electronic correlation and electron-phonon couplings. They present a remarkable flexibility allowing to tune their optical, electronic and mechanical properties at will through molecular engineering, making OCMs most suitable for a broad range of technical applications ranging from optoelectronics, as components of light-emitting diodes, to photovoltaic cells. Rigidity and conjugation, as well as the interchromophoric geometry, play a crucial role in the primary energy transfer mechanisms along aconjugated polymer (i.e., through-bond or through-space processes). The strong coupling between the electronic and nuclear degrees of freedom leads to self-trapping and spatial localization of excitons, in a region whose spatial length is determined by conformational defects. Manipulating these nuclear degrees of freedom may lead to a blockade or an enhancement of energy transfer along the bond. Recent experiments have pointed out that in specific polymers exciton transfer is a coherent process rather than a sequence of incoherent hopping type events. The accurate description of these photoinduced pathways considering all degrees of freedom involved constitutes a challenge to date. The goal of the fellowship is to advance state-of-the-art computational methods for describing the photoinduced and laser-driven, coupled electron-nuclear dynamics of large conjugated molecules, with the aim to include quantum coherence effects and to enable predictive calculations of exciton dynamics and of energy transfer in such polymeric systems. The researcher will carry out the fellowship in the Laboratory of Collisions, Aggregates and Reactivity, University of Toulouse III, under the supervision of Dr. Nadine Halberstadt.

Mots clés : surface hopping, quantum trajectories, organic conjugated materials, exciton dynamics, local control theory, mixed quantum classical methods

Participants :
- CY Cergy Paris Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Toulouse (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
- Université de Potsdam (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet REGRAMM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Language is one of the hallmarks of what it means to be human and grammar is a core linguistic ability that makes us able to understand (receptive grammar) and express (expressive grammar) the relationships between words in sentences. This ability is fundamental for participating in the educational, economic, social and cultural life of society, while impairments of grammar can lead to life-long difficulties in these areas. The acquisition of grammar is, thus, one of the most important developmental steps in young humans. Recent theories emphasize the complex interplay between linguistic and non-linguistic processes in grammar acquisition. Two non-linguistic processes that have been proposed to be tightly linked with grammar, primarily with receptive grammar, are executive functions (EFs) and rhythm processing. The interplay of these abilities with receptive grammar, however, have never been systematically tested. The proposed project aims to fill this gap by investigating the relationships of receptive grammar with EFs and rhythm processing in an individual differences behavioral study in a large group of children. The project will also develop and validate a gamified battery that will facilitate conducting large-scale in-person or web-based studies with children in the future. The results of the proposed project will help to determine if an exhaustive model of grammar acquisition needs to incorporate EFs and rhythm processing. Disentangling factors affecting grammar acquisition will help to improve the health and well-being of children by optimizing their learning environment and developing effective treatment programs for children with language disorders. The gamified battery I will implement will facilitate large-scale data collection with children in developmental cognitive sciences and lay groundwork for developing research-based apps to facilitate cognitive development of children with typical and atypical language development.

Mots clés : grammar, executive functions, musical rhythm, school aged children, individual differences, gamification

Participants :
- Université de Potsdam (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet EuBrand (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

EuBrand sheds light on a forgotten chapter of Europe’s intellectual and artistic history based on the following research question: how did painting contribute to the creation of a visual language of absolutism during the reign of the first Prussian king Frederick I? EuBrand fosters research and innovation by combining historical enquiry and augmented reality technology. At the very beginning of its life as a Nation State, Brandenburg Prussia, and Berlin in particular, experienced the afflux of immigrants artists and masters, fleeing France after the revocation of the Edict of Nantes (22 October 1685). Their presence in Berlin would change forever the city from a productive, social, artistic and aesthetic point of view. Brandenburg had never had before inborn artists. The first ones become visible only after the Huguenots' migration. One of them is the first Berlin-born painter and etcher Johann Friedrich Wentzel (1670-1729), whom Frederick I King in Prussia commissioned the monumental ceiling frescos of the newly transformed Berlin Castle. EuBrand emphasizes the importance of migration and movements of people across Europe in the creation of an iconography of absolutism functional to Frederick’s dynastic project. Wentzel’s personal and artistic trajectory is exemplary in this respect. His activity at the castle will provide the basis for an innovative app for visitors of the newly inaugurated Humboldt Forum, highlighting the forgotten layers of Brandenburg’s history behind one of the major landmark of today’s Berlin. EuBrand speaks in a timely way to the ongoing debate on the restitution of the Berlin’s castle, allowing a better understanding of the site. It contributes to the denationalization of German historiography and meets the need for accessibility and engaging story-telling in cultural heritage by exploiting the potential of the digital transition for research and curatorial purposes.

Mots clés : johann friedrich wentzel, berlin castle, iconography and power, digital curatorship

Participants :
- Centre de recherche du Château de Versailles (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Potsdam (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet SUNSET (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Nanotechnology has grown at an exponential rate in the last decade, finding a large application in the biomedical field. Nanoparticles are emerging as effective drug delivery tools, since they overcome most limitations of free therapeutics - while offering a series of physical/chemical advantages. Among engineered nanomaterials, selenium nanoparticles (SeNPs) have shown a growing potential as a therapeutic platform since they offer both the properties of selenium (Se) and the ones of a nanoscale system. SUNSET project aims is to design and develop a hydrogel-based nanocomposite containing multi-functionalised SeNPs, to use as an effective nanoplatform for cancer gene therapy. The designed system will be evaluated in resistant melanoma, specifically BRAF mutated lesions, which represent 66% of the cancer cases and are those that show resistance to currently available therapies, causing most cancer deaths. Here, the synthesis of SeNPs is followed by surface functionalisation with a specific small interfering RNA (siRNA) and their embedding in the polymeric phase. All the materials will be synthesised through green chemistry routes, to guarantee a low environmental impact of the procedure and its scalability and reproducibility. The anticancer activity of the nanocomposite will be evaluated both in vitro and in vivo. Overall, the combination of RNAi technology, nanomedicine and biocompatible materials – selenium and natural hydrogels – will be useful to gain a more efficient therapy, overcoming the main current challenges in the care of resistant melanomas. Moreover, the simplicity of the fabrication and the possibility to scale up the procedure, make the proposed system possibly attractive for clinical applications, promoting European Scientific Excellence. Lastly, I will have the possibility to start new cross-disciplinary collaborations that will pave the way for my future research career.

Mots clés : selenium nanoparticles, nanomedicine, melanoma, targeted gene therapy, braf mutation, rna interference

Participants :
- University Medical Center Groningen (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
Projet GeometricLAMs (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

As the climate crisis progresses, and we see an increase in extreme temperatures, the importance of accuracy in regional weather forecasting significantly increases. These regional models, or limited area models (LAMs), run at the highest feasible resolution to well resolve fine grain features in the model. Due to the global nature of the atmosphere, LAMs are coupled to a global forecast model, which due to the larger size must run at a coarser resolution and does not see the fine grain structures. This project will increase the accuracy of this coupling between LAM and global model. Specifically, the core focus is to utilise deep learning to recover accurate fine grain structures from a coarse global model to be incorporated as boundary data to the LAM. The philosophy followed is that if one wants to couple two models it is paramount to preserve the physical structures between the two models. One may think of such structures as conserved quantities here. In addition to utilising this philosophy to optimise the coupling between models in the traditional (deterministic) sense, new technologies in structure preserving deep learning will be developed. These aim to resolve the fine grain features to be qualitatively consistent with a global model ran at high resolution. This is an interesting problem from a mathematical perspective as it applies expertise from numerical analysis and geometric numerical integration to develop the field of machine learning.  This project has been designed to be in line with the UK Met Office atmospheric models and is of high research interest to them.

Mots clés : structure preserving deep learning limited area modelling regional weather forecasting geometric numerical integration conservative discretisations

Participants :
- Université norvégienne de sciences et de technologie (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 210911.04 €
- Met Office (Royaume-Uni) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
Projet T-REaCT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cancers are characterized by the accumulation of somatic mutations in the DNA. The human immune system can detect such mutations in cancers via T cells, which forms an important factor in the activity of clinically used cancer immunotherapies. What challenges our classic view of cancer formation are the recent breakthrough discoveries showing that somatic mutations are ubiquitously found in healthy tissues - why only some of these mutations lead to clonal outgrowths and what are the factors sustaining them? As T cells recognizing somatic mutations are abundant in cancer, it is plausible to speculate these interactions could start early in tumor evolution. Albeit of high interest, studying this phenomenon has been technically challenging as it requires the ability to obtain mutational data at single-cell resolution and interrogating T cell specificities.  The T-REaCT action aims to experimentally map the co-evolution of T cells and cells carrying somatic mutations across tumor evolution. By combining two novel sets of tools and expertise from two competitive fields of synthetic T cell reactivity screening (mentor Dr Schumacher, Netherlands Cancer Institute, the Netherlands) with single-cell genomics (co-mentor Dr Landau, Weill Cornell Medicine and New York Genome Center, the US), we will create a roadmap of immune responses in human colon samples ranging from healthy tissue to adenomas to overt cancer.  By describing the formation of T cell reactivity against somatic mutations from pre-malignant to the earliest steps of malignant seeding, our project has the potential to revolutionize early cancer detection and the eradication of (pre-)malignant lesions through personalized immunotherapies.

Mots clés : tcr, tcr specificity, cancer immunology, single cell genomics

Participants :
- Université Cornell (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- New York Genome Center (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
- Antoni van Leeuwenhoekziekenhuis (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 217076.16 €
Projet R2D2 (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

A century after its discovery, the atomic nucleus remains a subtle organization of protons and neutrons interacting through QCD. Its properties are the driving mechanism of cataclysmic events in the cosmos like those leading to the synthesis of medium-to-heavy elements. Unfortunately, precise, fundamental nuclear data, which are essential both to the sustainability of our civilization through technological applications, and to our understanding of the universe, are still a considerable undertaking to measure or to compute. Our objective is to unlock the applicability of ab initio predictions of nuclear collisions, which have been, so far, lagging behind that of static properties of nuclei. To reach this goal we aim: 1) To develop perturbation theory to ab initio reaction modeling, and by this means to open up to reacting systems above the p-shell; 2) To exploit the aforementioned development in the context of strict effective field theory for nucleons. We expect these achievements to allow us to contribute to the understanding of the detailed balance between nucleons that will be uncovered at the edges of nuclear stability at facilities like Spiral2 in France and FAIR in Germany. The experience researcher (ER) will bring to the host group its know-how in perturbative methods, of which he has been a practitioner in nuclear structure, and, in doing so, he will boost the applicability of the host ab initio reaction tools. In turn, he will benefit from the supervisor’s expertise in reaction theory and effective field theoretical tools thereby acquiring a strong and valuable portfolio aiming to perform nuclear evaluation of data and predictions for supporting both theoretical and experimental nuclear astrophysics needs. In conclusion, this project is mutually beneficial to the host group and the ER. It will increase the ER visibility both at the EU and international levels, ready his managerial and mentoring skills for future career opportunities in academia or industry.

Mots clés : nuclear reaction, ab initio methods

Participants :
- Université d'État du Michigan (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €