Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SSeMID (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : CLOSED

The increasing environmental awareness of the European society has been always present in the aeronautical community, industry and research centres, having a definite influence on the way the aircraft of the future should be. In this line, the ACARE Vision for 2020, a Group of Renowned Personalities in the aeronautical field, has formulated a clear set of requirements for civil transport aircraft operations in order to reach the following specific environmental goals: halving perceived aircraft noise, 50% cut in CO2 emissions per passenger-km and 80% cut in NOx emissions. Many of these goals have a direct connection with the aerodynamic performance of the aircraft; mainly with aerodynamic technologies. Most of the elements of the aerodynamics of conventional aircraft are modelled and understood to some degree but reliable solutions are not available due to new challenges appearing as the technology matures. One of the most common problems is related to stability analysis for configurations in the limits of the flight envelope or when unsteady effects are dominant. This challenge is the object of the research of SSeMID, and is the focus of the international training plan for young engineers employed within the network. The project will provide valuable information for such aerodynamic structures paving the way to its complete industrialization while increasing the academic knowledge regarding instability mechanisms and covering the necessary skills and knowledge to train experts in this area

Mots clés : stability analysis, flow control, fluid mechanics, computational fluid dynamics, applied mathematics for aeronautic

Participants :
- Von Karman Institute for Fluid Dynamics (Belgique) — Partner, beneficiary, Recherche, subvention : 250560.0 €
- Numerical Mechanics Applications International (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 160080.0 €
- Office national d’études et de recherches aérospatiales (France) — Partner, beneficiary, Recherche, subvention : 625059.76 €
- Imperial College London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 558721.89 €
- KU Leuven (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 229680.0 €
- Airbus (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 372506.56 €
- Universidad Politécnica de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 743618.88 €
- University of Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- Airbus (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 173841.46 €
- German Aerospace Center (Allemagne) — Partner, beneficiary, Recherche, subvention : 249216.48 €
- KTH Royal Institute of Technology (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 263659.32 €
Projet RESET (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The increasing incidence of extreme events (e.g. fires, insect outbreaks) in combination with ramp and press disturbances such as climate and land-use changes are seriously threatening the persistence of forest services on which human well-being depends. In this context, forest resilience to disturbances has become a paradigm for researchers, practitioners, and policymakers. Whereas many indicators have been proposed in different empirical studies, most of them are based on a static view of ecosystem states and overlook that ecosystem states, in fact, represent dynamic regimes. In contrast, many advanced theoretical approaches remain unexplored in specific forest systems. In this sense, incorporating theoretical resilience concepts into empirical studies poses a key challenge to developing realistic management practices and policies that promote forest resilience to upcoming disturbances. This proposal aims to fill an important scientific gap by applying resilience concepts from theoretical ecology into empirical case studies. The main objective is to contribute to the conservation of forests and prevent their degradation and loss by improving our capability to identify resilient and tipping-point communities, assessing the mechanisms underlying post-disturbance forest dynamics, and supporting forest management and policy through useful information and tools. This project proposes an innovative framework to assess forest resilience to pulse (e.g. insect outbreaks, fire), ramp (climate change) and press (land-use change) disturbances accounting for forest dynamic regimes as reference to compare post-disturbance dynamics. The collaboration with theoretical and quantitative ecologists and researchers in the science-policy-practice interface from some of the most prestigious institutions in the EU will guarantee a strong contribution to the understanding of post-disturbance forest dynamics and the preservation of forest services under changing conditions.

Mots clés : resilience, resistance, dynamic regimes, forest dynamics, disturbances, climate change, land use change, trajectory analyses, hypervolume, cluster

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 184707.84 €
Projet HaPpY (Horizon 2020, appel à projets 2020)
Action : Doctoral Networks - Joint Doctorates
Panel : Life Sciences
Statut du projet : SIGNED

The increasing number of patients with comorbidities poses an urgent need to improve their management. Among these comorbidities, chronic pain and mood disorders, two long-lasting disabling conditions that significantly reduce quality of life, could be cited first. Given the importance of this comorbidity, we believe that only research considering both pathologies in an integrative way can achieve the required insights into the underlying mechanisms that are necessary to identify novel diagnostic tools and treatment strategies. To respond to this health and societal emergency, we propose to establish a network of academic institutions and companies to provide 15 early stage researchers (ESRs) with a top quality international training programme. The HaPpY network is comprised of higher education institutions with very well-established track records of scientific and academic excellence, and of research institutes with significant experience and cutting-edge approaches in fundamental research on mood disorders or/and pain. To ensure that discoveries in fundamental research can swiftly move toward clinical settings, to the benefit of patients and society, our consortium is enriched by clinical centres, companies and other non-academic partners. This consortium thus enables a unique research and training programme by combining and integrating the complementary strengths of each partner. HaPpY will thus provide ESRs with a broad scientific knowledge and foster their creative skills which will enable them to become leaders in either the academic or non-academic sectors. We believe that only a coordinated programme aiming to train a new generation of talented and multidisciplinary researchers can succeed in our ambitious endeavor to break the vicious cycle linking pain and mood disorders.

Mots clés : comorbidity, pain, depression, human studies, rodent studies, sexual dimorphism, neuroscience, medicine, pharmacology, diagnostic, treatment strategies

Participants :
- Kiel University (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- University of Cádiz (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 501809.76 €
- University of Helsinki (Finlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 561611.52 €
- Central Institute of Mental Health (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- University Hospital Heidelberg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- National University of Ireland (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 824052.96 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 824406.12 €
- University of Minho (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 475440.48 €
Projet sTUCk (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The indispensable status of translation and translators in Iran, the availability of multiple translations of the same works, and the strict censorship imposed by the government on translators make the Iranian situation a promising object of translational research, well beyond its areal provenance. The proposed research will try to describe the main characteristics of the particular field of literary translation in Iran by analyzing the dynamics between different role players competing with each other in this field. It will then try to explore the true nature of limitations and constraints that Iranian translators are exposed to and discover different strategies that they use in practice to deal with these limitations and constraints. To this end, an English novel and its multiple Persian translations will be carefully examined in the light of information obtained from interviews that will be conducted with the Iranian translators of the novel.

Mots clés : translation studies, censorship, iran, persian, bourdieu s sociological field theory

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166320.0 €
Projet MechHelicaseActiv8on (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The initiation of DNA replication requires dynamic biomolecular interactions, which are temporally and spatially regulated to allow genome duplication only once per cell cycle. During eukaryotic replication initiation, the MCM helicase is loaded as an inactive double hexamer encircling double-stranded DNA (dsDNA). It is activated by a set of proteins called firing factors in a kinase-dependent manner, thereby forming the CMG complex (Cdc45, MCM, GINS), which encircles single-stranded DNA (ssDNA) and thus can unwind dsDNA. Although the essential components for helicase activation are known, we do not understand the remarkable topological transition between the inactive helicase encircling dsDNA and the active helicase encircling ssDNA. For this to happen, the ring-shaped MCM helicase must open between two subunits in a regulated manner. Therefore, I aim to (1) uncover the trajectory of ssDNA ejection from the helicase central channel and (2) dissect the role of firing factors in helicase activation. The objectives of the proposal are to determine (i) which helicase subunit interface has to open to eject ssDNA, (ii) which region of helicase interacts with ssDNA during helicase activation, (iii) what is the topology of helicase activation intermediates and (iv) which firing factors interact with ssDNA during strand ejection. I will employ biochemistry with various crosslinking strategies combined with mass spectrometry to characterize the dynamics of protein-protein and protein-DNA interactions during helicase activation. Using cryogenic-Electron Microscopy (cryo-EM), I will investigate the structure of intermediates of helicase activation. MCM helicase subunits and firing factors are conserved from yeast to humans, and their increased expression is correlated with poor survival in cancer patients. Since flexible interfaces of protein-protein interactions are promising drug target, results obtained during this project will facilitate anticancer drug design.

Mots clés : dna replication, protein protein interactions, nucleoprotein complexes, helicases, cryo em, crosslinking mass spectrometry, replication initiation

Participants :
- The Francis Crick Institute (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 212933.76 €
Projet STIMULATE (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The innate immune response to cytosolic dsDNA via the cGAS-STING pathway has been shown to be essential in the response to various viral, bacterial and parasitic infections, in autoimmunity and in cancer. However, the relationship between STING signalling and metabolism is currently unknown. In recent years, our understanding of immunometabolism has also increased – it is becoming clear that metabolic adaptations are fundamental for immune responses. Due to its role in this wide range of clinical pathologies, the mechanism of STING signalling has received a great deal of scientific interest and several STING-targeting compounds are now reaching clinical trial stages of development. It is therefore important to understand the effect of STING activation on mammalian cells, as well as how to manipulate this response to the greatest effect. The research proposed here focuses on the relationship between cellular metabolism and innate immune signalling via STING, using an unbiased proteomics approach as well as targeted immunometabolism approaches to find STING modulating metabolic pathways. Having completed my PhD studies in immunology, I am pursuing a postdoctoral project, in the lab of Dr. David Sancho at the CNIC, that utilises my expertise and allows me to expand my technical horizons and enhance my career development. As an expert in innate immune signalling I believe that combining my knowledge with the Sancho lab’s expertise in cellular immunobiology and metabolism will lead to a better understanding of our immune system. As well as the expertise of my host lab, I will also benefit from the collaboration of leaders in proteomics and mitochondrial biology. This Individual Fellowship would greatly benefit my current research objectives and my career as a whole by allowing me to explore my research interests in a supportive environment, where I will receive the training required for the next stage of my research career.

Mots clés : immunometabolism, macrophages, innate immunity, mitochondria

Participants :
- Ministry of Health (Espagne) — Coordinator, beneficiary, Recherche, subvention : 160932.48 €
Projet WC-Cult (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The input of the humanities and social sciences is vital in fostering a viable civil society. Informed public debate concerning the good life needs the kind of reflexive cultural self-understanding that they can offer. In cultural reflection, conceptual analysis, which is the domain of philosophy, has a key role. This vision of philosophy and the human sciences as cultural self-knowledge currently remains a minority view. However, during the twentieth century, it found powerful proponents in two leading philosophers of history and the social sciences: R.G. Collingwood (1889–1943) and Peter Winch (1926–1997). The aim of the planned project is to confront these two thinkers and tease out their underlying visions of philosophy. By engaging with these thinkers, the present project reopens questions about (1) the place of philosophy among the sciences, as well as (2) issues concerning the very nature of philosophical inquiry and (3) its impact on civil society and its challenges. The relation between Collingwood and Winch remains almost completely unexplored at present. The relationship between philosophy and human historicity, which was a key issue for both, presently remains underdeveloped in the analytic tradition. The planned research will take advantage of extensive manuscript material at the Centre for Ethics as Study in Human Value (CE) at the University of Pardubice (UPa). The CE has the unique combination of full access to the relevant Peter Winch manuscripts and a team of scholars knowledgeable in the post-Wittgensteinian tradition to which Winch belonged. The project furthermore includes a short visit to the Collingwood Archives at Oxford. The scholarship will enhance the CE’s reputation as the ‘go-to’ place for anyone doing research in the post-Wittgensteinian tradition. It will help the ER establish his reputation as a global expert and to expand his research network in a new direction, i.e. towards scholars on idealism.


Participants :
- University of Pardubice (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 78490.32 €
Projet USEMITE (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The integration of III-As structures with Silicon is of major importance to industry. Currently nanostructures are already being applied to information and communication technologies and their integration with Silicon electronics is being developed. Current fabrication techniques allow patterning of nanostructures from bulk layers but modify the properties of the materials by introducing defects. The ability to control nucleation and growth of self-assembled quantum nanostructures will propel the development of electronics and photonics. The combination of in-situ Low Energy Electron Microscopy (LEEM) during Molecular Beam Epitaxy (MBE) offers the possibility to directly observe the growth on real-time in real and reciprocal space. Therefore, to observe the nucleation dynamics, the lattice structure dynamics, surface dynamics, etc. The level of control that LEEM can provide to MBE is unheard of and unique. The goals of the MSCA project are: • Elevate current III-V LEEM system to enable direct interaction with MBE facilities, both research and industry based, across Europe. • Apply the technique to the fabrication of site-controlled nanostructures. • Transfer the growth conditions found during direct observations of the growth by MBE-LEEM to industrial fabrication of quantum devices. During the MSCA period, the LEEM-MBE will be used to study the nucleation of GaAs on Si, the nucleation of InAs QDs on GaAs, nucleation of InAs QDs on complex structures to induce site control nucleation using strain field, nucleation and growth of nanowires (NWs) using catalysts and self assembled. Additionally an aluminium anodization system will be fabricated and installed in order to deposit the catalyst in a hexagonal lattice along the area of the whole substrate. The latter project will be carried out by a PhD student which will be funded by Cardiff University.

Mots clés : photonics, crystal growth, microscopy, molecular beam epitaxy, new electronics, semiconductor nanostructures

Participants :
- Cardiff University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet ConFoBiNM (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The integration of conservation into production forest management is crucial to achieve desired biodiversity goals at the EU level. Retention forestry, which was introduced as a tool to mitigate the negative impact of transformation and homogenization of forests, is now common practice in Central European forests. The design of efficient retention strategies hinges on ecological knowledge, yet research-based evidence for its effectiveness is lacking. In particular, responses of large terrestrial mammals to variable retention harvesting are unknown. I will address this knowledge gap by using a combination of advanced techniques and statistical methods to investigate how the large mammal community changes in response to varying levels of retention forestry in multiple-use forests, and assess the interplay between retention forestry and the surrounding landscape. I will (a) quantify mammal species richness, species-specific abundance and β-diversity across a gradient of retention forestry and landscape forest cover, and (b) determine a threshold of retention at which significant responses occur. I expect that retention will enhance mammal diversity, but not below a certain threshold or below a certain amount of forest cover. I will use the Black Forest in Southwestern Germany as a model system for multiple-use forests in Central Europe, and conduct camera-trapping in 135 plots embedded in patches of mixed-montane forests which differ along 2 gradients of retention and landscape fragmentation. I will use multispecies hierarchical modeling in a Bayesian framework to quantify the effects of retention forestry on mammal species at different spatial grains. This multidisciplinary research combines spatial ecology, with landscape and forest ecology and will integrate for the first time ecological study of large mammals and retention forestry in Central European landscapes.

Mots clés : camera trapping, large terrestrial mammals, spatial ecology, temperate forests

Participants :
- University of Freiburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162806.4 €
Projet PhotoSMM (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The integration of molecular-scale components in circuits may ultimately allow the replacement of silicon-based electronics by high speed systems with low energy consumption. Because of the prominent use of magnetization-based information storage technologies in our daily life, Single-Molecule-Magnets (SMM), which are able to interconvert between two states with opposite magnetization directions receive a great deal of attention. The potential is huge for SMM systems that would demonstrate magnetic field- and light-driven changes in both their optical and magnetic properties because they could reproduce on a single molecule the same type of magneto-optical (MO) effects which are used for some current data storage technologies. Photo-SMM will demonstrate that a light input can induce a modification of the magnetic and optical properties of monometallic or bimetallic SMM. This will be achieved thanks to the unprecedented association of anisotropic ions with photochromic ligands designed to produce very different coordination environments in their two isomeric states, thus maximizing the impact of photo-isomerization on the ligand field experienced by the 4f or 3d metal ions and on the resulting magnetic behavior.

Mots clés : molecular magnetism, single molecule magnet, photochromism, molecular switches, 4f ions, 3d ions

Participants :
- Université de Rennes (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 119901.6 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €