Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet R2STAIR (Horizon 2020, appel à projets 2020)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

R2STAIR will boost the career prospective of R2STAIR will boost the career perspectives of 8 junior R2 fellows (PhD holders who are not yet fully independent) by training their skills throughout the research life cycle in Prehistory and Human Evolution studies (from fieldwork to a societal impact through heritage enhancement). To this end, this program will complement IPHES’ experience on interdisciplinary research and intersectoral collaboration with about thirty international Partner Organisations (Research Institutes, Universities, Museums and City Councils), willing to host specialised secondments. Furthermore, short and medium stays, with specific first-hand training in ongoing processes of heritagisation promoted by IPHES, will be facilitated around archeopaleontological sites such as Sierra de Atapuerca, Barranc de la Boella or Camp dels Ninots. These processes are providing, at different scales, evidences of political and socioeconomical impact of IPHES’ activities, as examples of how Prehistory and Human Evolution Studies can be lead to Public-Private-Partnerships, Tourism Master Plans or a Regional RIS3 project. This will be done without prejudice of choice alternative entities according to the 'Individual driven mobility principle'. IPHES has a strong research profile in Prehistory and Human Evolution through a concentration of multidisciplinary approaches to the archaeological record, having an extended presence in different scientific communities. For instance, between 2014 and 2018 IPHES has published 464 papers in 87 journals with Impact Factor at 22 different WOS Subject categories, reflecting the broad spectrum of the research carried out. As a result, fellows will benefit from the IPHES’ experience and will also contribute to improve the European Research Area as one of the most attractive environments to grow and progress as a researcher, boosting its international visibility and further increasing the quality of research and innovation developed.

Mots clés : prehistory, human evolution, postdoctoral training, research lifecycle, cultural heritage enhancement

Participants :
- CERCA Institution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 588480.0 €
Projet REDAFLOW (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

REDAFLOW aims to develop a generalised, computationally efficient and scalable modelling framework for simulating turbulent and reacting flows, aimed at the latest and emerging high-performance computing architectures. Current state of the art classic modelling approaches developed from simplifying assumptions (in-compressible, self-similar, non-reacting) limit the generality and application domain of computational fluid dynamic simulations which is becoming the workhorse in industry for virtual prototyping. At the same time, a large number of flow-dependent and reaction-dependent model parameters limit the predictive ability and robustness of numerical simulations. The novelty of the proposed framework is twofold: reconstruction/deconvolution will be employed for modelling in a generalised and parameter-free framework unresolved terms in the governing equations while machine-learning will be employed to model the chemical kinetics including detailed-chemistry effects. The necessary filtering and interpolation schemes as well as all the deconvolution algorithms and chemistry neural network libraries will be developed in-house in stand-alone libraries, and optimised for use with state of the art parallelisation libraries. The proposed framework is expected to reduce the computational time required for tabulation-based reacting flow simulations, improve the simulation predictions, and allow a wider range of practical flows to be simulated under a generalised framework, irrespective of the flow or reaction regime. The tools and libraries developed are expected to attract the interest of a range of industries (chemical, automotive, aerospace, software, consulting) where simulation is the main tool for developing improved processes and designs for a wide range of engineering devices.

Mots clés : computational fluid dynamics, large eddy simulation, turbulence, combustion, reacting flows, chemical kinetics, deconvolution, machine learning, modelling

Participants :
- Institut national des sciences appliquées de Rouen Normandie (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 295061.76 €
Projet REGGAE (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

REGGAE will showcase the role of scientists in the achievement of a greener, more resilient and innovative European society, by involving researchers and public side by side in lively activities. By engaging adult citizens and showing how innovation and knowledge can lead to growth and to a more sustainable future, the project will also contribute to reinforce trust in science and its methods. Young researchers, as role models for students, will be involved in activities specifically designed for youngsters and schools, in order to promote STEM careers. The topics addressed in the activity programme will cover the main areas of the European Green Deal, namely, climate ambition; clean energy; circular economy; energy and resource efficient buildings; sustainable and smart mobility; farm to fork; biodiversity and ecosystems; zero-pollution and toxic free environments. The programme of ERN and warm-up events will include lively formats like hands-on activities, workshops, science shows, science cafés, demonstrations, informal talks with researchers and guided tours, specifically designed according to the age-group and social background of the participants. The detailed programme will be developed by a consortium that includes research centres - IBMC and ITQB - and science communication institutions closely connected to universities (science centres of the Ciência Viva National Network). All the participating institutions have a large experience in organizing both face-to-face and online engagement activities, enabling to ensure an extensive impact of the project even if health contingencies still apply. Both the research centres and the Ciência Viva network provide extensive dissemination channels that will ensure the engagement of a wide range of stakeholders and publics.

Mots clés : researchers, citizens, public engagement, interaction, non formal education, green growth

Participants :
- Ciência Viva (Portugal) — Coordinator, beneficiary, Autres, subvention : 82187.5 €
- Universidade Nova de Lisboa (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 36250.0 €
- University of Porto (Portugal) — Partner, beneficiary, Recherche, subvention : 35443.75 €
Projet SCIENCEatHOME (Horizon 2020, appel à projets 2016)
Action : European Researchers' Night
Statut du projet : CLOSED

RN 2016 and 2017 Turkey is organized in Ankara by the Science and Society Center of Middle East Technical University (ODTÜ) to promote public recognition of science produced via EU and nationally funded cutting-edge R&D&I projects around the theme of “Science@Home”. This innovative theme is utilized because home is a familiar concept to us all, and this familiarity has great potential to break the conceived barriers between science and society. The setting will be designed such that our audience will feel like she/he is walking in their house from their kitchen to their bathroom, on to the living room and then out to the garden and garage. This familiar surrounding will be the storytelling grounds of how science surrounds us everyday. Storytellers will be researchers themselves presenting outcomes of their research in a vast spectrum of disciplines. Science@Home proposes to train public at large to act more environmentally conscious and be educated in terms of health and safety at home. We will reach a dynamic network of science communicators through ALTRU - the Alliance of Turkish Research Universities, comprised of the top-six distinguished Turkish research-intensive universities. We aim to reach 10,000 on-site participants and 1,000,000 on-line or indirect beneficiaries regardless of their age and background. The ultimate messages conveyed via Science@Home will be “What’s up with R&I?”, “Researchers are amongst us” “Science is fun and very much integrated in our everyday lives”. Celebrating discovery and exploration can be a life-changing experience for our beneficiaries. Appreciating science that brought comfort to our daily lives will also inspire younger participants to take on careers in science. Interacting with experts while eating pizza, listening to science celebrities and partaking in a science masquerade is sure to be a truly memorable experience and will promote a positive reputation for scientific research.

Mots clés : scientific outcome and products, science communication, science in the kitchen, living room, bathroom, garden and garage, environmental consciousness, science celebrities, science masquerade

Participants :
- Middle East Technical University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173250.0 €
Projet LARP4MOT (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

RNA-binding proteins (RBPs) act at multiple levels to regulate gene expression, including mRNA splicing, polyadenylation, localisation, stability, decay and translational efficiency and, although central to health and disease, much of this precise concerted regulation remains to be uncovered. The recently discovered LARP4 is an RBP that affects mRNA stability and binds to polyA as well as the polyA-binding protein (PABP). Intriguingly, LARP4 has recently been identified as a regulator of cell morphology and migration in an RNAi screen, but little is known about how control of gene expression at the translational level is coordinated during cell migration and invasion. Since aberrant cell migration contributes to the development of human diseases including cancer, chronic inflammation and atherosclerosis, LARP4 represents an excellent RBP to advance our understanding of key cellular mechanisms relating to mRNA processing and turnover. The overall aim of the project is to understand at a molecular level how LARP4 regulates mRNA translation and how this impacts on cell migration, especially in the context of cancer cell biology, using human prostate cancer cell lines as models. For this, a multidisciplinary approach combining biochemistry, biophysics, structural and cell biology will be used.

Mots clés : larp4, larps, protein rna interactions, structural biology, cell migration, cancer biology, control of mrna translation, molecular and cell biology, cell motility pathways, rna biology

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet NeuroRBP (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

RNA-binding proteins (RBPs) coordinate post-transcriptional regulation immediately after transcription by RNA-processing, nuclear export, localization, stability and translation rate of RNAs. The importance of these RBPs in neural development have been underscored by detecting their mutations in severe neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), ataxia or tremor. In this project, using the assays that I developed specifically for the identification of RBPs I want to track down novel RBPs involved in neural differentiation. I will use patient-derived induced pluripotent stem cells (iPSC), as model system to discover RBPs that their malfunction may lead to neurodegeneration. Furthermore, I will identify the binding targets of the RBPs to determine the pathways that are affected. Finally, using machine-learning methods I will integrate these data to shed new light on the mechanism of neural differentiation and degeneration. The output of this project in long term will help to identify individuals at risk, and to develop better therapeutic approaches to treat neurodegenerative diseases.

Mots clés : patient derived ips cells, neural differentiation, rna binding proteins

Participants :
- The Francis Crick Institute (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 195454.8 €
Projet SaRe-DiGT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Rahaf Mohammed, an 18-year-old Saudi woman who was subjected to domestic violence, utilized social media to make her voice heard by foreign authorities. Via this ‘digital’ call for help, she successfully escaped violence. The internationally recognized #metoo movement became active on social media enabling women victims of gender-based violence (GBV) to seek justice and healing. While these examples show how digital technologies can allow individuals to exercise their agency and communicate their voices against violence, the existing academic studies in the field of GBV have yet to discuss the empowering outcomes of digital technology use for and by victims/survivors. By addressing this gap, SaRe-DiGT aims to uncover the potentialities of digital technologies in enhancing victims'/survivors’ physical and emotional safety against violence. I particularly focus on the patterns and practices of digital technology use by immigrant women who have experiences of GBV. Considering the numerous barriers that immigrant women face while seeking safety from violence, SaRe-DiGT stresses on the instrumental use of digital technologies as a practical resource for information, communication, and mobilization to overcome violence. The project includes three phases: i) participatory focus groups, to identify and examine the opportunities enabled by digital technology use in women’s lives to navigate their ways towards safety and resilience from violence; ii) digital storytelling workshops, to co-develop resilience-promoting practices enabled by the creative use of digital technologies; and iii) website designing workshops, to co-design an online initiative as a practical digital resource to assist immigrant women in their efforts to reach safety and build resilience. In achieving these objectives, SaRe-DiGT will provide unique research-based knowledge and solutions to create transformative technology-facilitated strategies to combat violence among immigrant communities in Europe.

Mots clés : gender based violence, resilience and agency, digital sociology, participatory visual methodologies, technology facilitated strategies to seek help from violence, violence against immigrant women

Participants :
- University of Stavanger (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €
Projet RainForest-GHG (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

RainForest-GHG aims to quantify ecosystem sinks and emissions of three major greenhouse gases (GHGs), i.e. carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O), in a tropical rainforest, and examine the contributions of the soil and the woody tissues to the ecosystem-scale GHG fluxes. RainForest-GHG further aims to determine the main environmental drivers responsible for the temporal and spatial variations of these GHG fluxes.

Mots clés : ecophysiology, ecosystem gas emission, frorest dynamics, global carbon cycle, greenhouse gases, soil, trees, tropical rainforest

Participants :
- University of Antwerp (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €
Projet Co-tRiP (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Ranges of individual fisheries are shifting in response to ocean warning. These shifts can cause economic disruptions if a fish population becomes less or more productive or moves out of traditional fishing grounds. Dolphinfish are known to exhibit strong responses to CC through shifts in spawning areas, larval growth, etc. Dolphinfish inhabit tropical and subtropical waters of the world, including Mediterranean, and it supports commercial, artisanal and recreational fisheries. Balearic Islands, provide a paradigmatic case-study area and fishery scenario for a process-based understanding of how CC may impact migrant species of commercial interest in Europe. Co-tRiP objective is to address ecological socioeconomic consequences of CC on a migrant pelagic fish species under fishing pressure in NW Med. Specific objectives include: 1) To estimate the effect of environmental variability on extension and localization of spawning area, phenology of reproduction and growth of dolphinfish; 2) to address how inter-annual variability of spatial distribution, phenology of reproduction and growth of species, and long-term environmental trends can be used in projecting impacts of CC, such as distribution shifts; 3) to evaluate how projected changes would potentially affect fisheries and anticipate the adjustment of industry. Using a multi-model approach, Co-tRiP will provide more insight into the effect of CC on distribution shift. Co-tRiP will build probabilistic maps, based on distribution models, for spawning area through merging disperses data from multiple sources. Models will be used to back-calculate environmental conditions for spawning in past and present, and project how these will change in future. Data will be used to feed a bio-economical model in order to project how phenological changes may impact fishery, and how it may use this information. Further projections on distribution and phenology will be performed using a suite of ensemble models based on CC scenarios.

Mots clés : pelagic fish, migratory species, spatial distribution shifts, phenology of reproduction, fish larvae, spawning area, modelling, bayesian, thermal increase

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 170121.6 €
Projet IonPEFC (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Recent developments in PEFC research have seen a significant enhancement of catalyst activities and a reduction of cost at a reduced loading of precious metals by employing novel Pt-based extended surface area nanostructures alloyed with transitional metals, but the low stability caused by the easy dissolution of transitional metals in acidic PEFC environment, and the large difficulty to be integrated into devices due to the unconventional morphology of extended surface area nanostructures as Pt/C nanoparticle catalysts limit them mainly to pure material research, resulting in an increasing gap with real high performance devices. IonPEFC will bring together the chemistry of nanostructure and ionic liquid (IL) synthesis with the engineering of fuel cells to develop PEFC electrodes with thin film catalyst nonstructures from PtNi nanowire arrays modified by protic ILs, targeting an improved understanding of structure-property relationships of electrodes to build high performance and robust PEFC devices. This will involve 4 research objectives: 1. To develop electrodes with thin film catalyst nanostructures from PtNi nanowire arrays based on the in-situ growing approach and to study the effect of post acid washing and annealing on the surface properties of PtNi nanowires. 2. To synthesize super hydrophobic, electrochemical and thermal stable ILs with high proton conductivity, oxygen solubility and diffusivity. The as-prepared ILs will be used to modify PtNi nanowire electrodes obtained to protect catalyst surface from Ni leaching in fuel cell operation. 3. To test in single cells the as-prepared and IL modified PtNi nanowire electrodes, and compare with conventional Pt/C electrodes. 4. To evaluate the long-term durability of the electrodes under real life-context at different European and international automotive driving cycles with the industrial partner. It is expected that substantial performance and durability improvements will result from this research.

Mots clés : polymer electrolyte fuel cell  pefc, electrodes, nanostructure, pt nanowire, ionic liquid, ptni, oxygen reduction reaction

Participants :
- University of Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet HeteroCancerInvasion (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Recent live cell imaging studies have demonstrated that cancer cells invade either as single cell or as cell group retaining cell-cell adhesion. In contrast to the well-documented single cell movement, little is known about collective cancer cell invasion. Given that a single tumour tissue contains various types of cancer cells and the collective movement of cancer cells is sum of the behavior of phenotypically different cells, we hypothesised that intratumour heterogeneity affect collective invasiveness. Careful dissection of the movement of diverse cancer cells is required to study the nature of collective invasion because different behaviour of heterogeneous cancer cells causes complication to understand the movement of whole cancer cell collective. In this study we will utilise and combine the single-cell resolution live cell imaging of 3D collective invasion assay with different types of cancer cell line generated by gene editing and mathematical modelling of invasion assay, which enable us to set up a lot of different possible starting configurations, to test our hypothesis. This project not only advance our current understanding of collective invasion of heterogeneous cancer cell population, but also will be beneficial to design better strategies to limit the invasion and metastasis of cancer.

Mots clés : heterogeneity, collective invasion

Participants :
- The Francis Crick Institute (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 195454.8 €