Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet PELICO (Horizon 2020, appel à projets 2015)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : CLOSED

The expertise, resources and specific knowledge of all participating parties will be combined to achieve a breakthrough in design, synthesis and application of peptide analogues (peptidomimetics) possessing photo-controlled biological activities, with special emphasis on anti-microbial and anti-cancer activities. The main idea behind the Project consists in chemical incorporation of artificial photo-controllable building blocks into known biologically active peptides by replacing their natural building blocks – the amino acid residues. Such a modification would provide photocontrolled peptidomimetics which can reversibly change their structure between two different photo-forms upon irradiation with light of different wavelength. The participating parties possess general know-how for design of the peptidomimetics which can exist in two photo-forms, biologically active and inactive ones, reversibly interconvertible by light of different wavelength. This opens a possibility to convert inactive peptidomimetics to active compounds by irradiation with physiologically benign light directly in tissues with very high spatiotemporal precision and can be a fundamental basis of new therapeutic strategies. The research staff exchange and other activities planned under the Project will be dedicated to accomplish four complementary work packages: (i) carrying out pharmacokinetic and toxicity studies of the photocontrolled peptidomimetics synthesized by the parties previously; (ii) evaluation of novel photocontrolled building block chemotypes for their compatibility with peptides; (iii) creation of new photocontrolled peptidomimetics, especially based on the novel building blocks and the know-how developed by the parties (e.g. using “stapled peptides” technology); (iv) multidisciplinary training of the researchers whose future work will be aimed at further development of the most advanced photocontrolled peptidomimetics as drugs suitable for photodynamic therapy.

Mots clés : anticancer peptides, antimicrobial peptides, molecular photoswitches, photodynamic therapy, photocontrolled drug candidates

Participants :
- Karlsruhe Institute of Technology (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 67500.0 €
- University of Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 108000.0 €
- Enamine (Ukraine) (Ukraine) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 409500.0 €
- Latvian Academy of Sciences (Lettonie) — Partner, beneficiary, Recherche, subvention : 103500.0 €
Projet MAPNET (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The exponential increase in mobile data traffic warrants disruptive changes in the design and management of cellular networks. The next generation (5G) networks target to support a variety of applications having diverse requirements in data rates, latency, energy, etc. To address this surge in traffic demand and the associated heterogeneity in service requirements, several candidate technologies are being investigated under the 5G vision, naming a few: 1) Ultra-dense network deployment for high spatial capacity; 2) Network slicing to support heterogeneous service requirements; and 3) Cloud radio access networks (CRAN), etc. An important element of the 5G vision is to achieve a 50% reduction in the total network energy consumption. To ensure that the future networks meet both the service and the sustainability requirements, energy-efficient designs and integration of renewable-energy sources into the network infrastructure are needed. To address the sudden capacity demands, on-demand network deployment is desired, instead of maintaining a permanently over-engineered infrastructure. Inclusion of these approaches result in highly complex and stochastic network topologies. Modeling and optimizing such networks is a challenging problem. State-of-the-art approaches are not adequate to model these new scenarios, and different mathematical techniques are required. This proposal addresses the optimization and modelling challenges pertaining to the energy efficiency and service requirements of the future ultra-dense networks by: 1) The development of novel energy-efficiency models to ensure energy–neutral network operation considering renewable energy sources; 2) Innovative modeling framework for self-organized drone-assisted network infrastructure; 3) A unified programmable network interface for network slicing considering renewable energy and on-demand drone deployments; and 4) Validation of the developed approaches in a software-defined mobile network platform.

Mots clés : programmable networks, network slicing, energy efficiency, drone aided cellular, system level modeling, optimization, renewable energy

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 185076.0 €
Projet REAL-NET (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : SIGNED

The exponential surge in the global data traffic driven by the skyrocketing proliferation of different bandwidth-hungry on-line services, such as: cloud computing, on-demand HD video streams, on-line business analytics and content sharing, sensor networks, machine-to-machine traffic arising from data-centre applications, the Internet of Things, and various other broadband services, brings about the escalating pressure on the speed (capacity) and quality (bit error rate) characteristics of information systems. It is well recognized nowadays that rapidly increasing data rates in the core fibre communication systems are quickly approaching the limits of current transmission technologies, many of which were originally developed for communication over linear (e.g. radio) channels. It is widely accepted that the nonlinear transmission effects in optical fibre represent now a major limiting factor in modern fibre-optic communication systems. Nonlinear properties make optical fibre channels considerably different from wireless and other traditional linear communications channels. There is a clear need for development of radically different methods for coding, transmission, and (pre & post) processing of information that take the nonlinear properties of the optical fibre into account and for training of a new generation of engineers with expertise in: optical communications, nonlinear science methods, digital signal processing (DSP), design of implementable algorithms. From the industry perspectives, design of practical and implementable processing algorithms requires knowledge of ASICs and real world conditions and restrictions. The mutli-national & multi-interdisciplinary REAL-NET project will provide timely doctoral training for 6 PhD students through industry relevant research in the fast growing area of high practical relevance and will lead to development of novel practically implementable disruptive techniques for fibre-optic communications.

Mots clés : real time monitoring, optical networks

Participants :
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- Orange (France) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut Mines-Télécom (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 549604.08 €
- Infinera unipessoal lda (Portugal) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Universitat Politècnica de Catalunya (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 501809.76 €
- Coriant r&d gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
Projet ResClust (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The extent to which nuclei can comprise lighter nuclear clusters in low-mass systems directly influences astrophysical production and decay rates. However, the scope of clustering away from stability has yet to be fully investigated. This proposal will address this by implementing novel measurement apparatus for exotic clustering in key short-lived isotopes using resonant elastic scattering and at the same time demonstrate an improved spectroscopic tool that can be applied to a wide range of nuclear structure studies. This is possible because of key charged-particle detector expertise of the ER and the Supervisor complementing both the ER's experience in radioactive ion beams and the MC40 cyclotron facility at Birmingham. Birmingham's world-class leadership in clustering and charged-particle spectroscopy make this location an ideal host. The result is a focused proposal that will lead to a flexible tool for extracting precise structure data from radioactive beam experiments, answering questions at the frontiers of nuclear stability, models and nuclear astrophysics. A significant reduction in beam-time required for such investigations will be achieved making the apparatus practical for use at international user facilities while opening more systems to this technique and reducing background.

Mots clés : nuclear clustering, resonant scattering

Participants :
- University of Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 91727.4 €
Projet FIBER (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The feedback between climate and the land carbon (C) cycle poses one of the largest uncertainties in climate change projections. FIBER targets the unresolved challenge for Dynamic Global Vegetation Models (DGVM) to simulate effects of soil fertility and nutrient deposition on biomass productivity (BP) and the land C balance. Accumulating evidence documents how plants adjust their growth strategies and C allocation under multiple limiting resources. Current DGVMs lag behind these new insights, produce widely diverging results for C cycling and nutrient limitation under future scenarios and fail to explain the observed land C sink. This work will provide a new global modelling approach to simulating flexible plant C allocation following optimality principles. A better understanding of the controls on BP is crucial for assessing climate change impacts on ecosystem services and to reduce uncertainty in C cycle and climate change projections. I will develop a new type of plant growth model to predict increased root growth and export of labile C to soil biota on infertile soils and under low N inputs, consistent with powerful data from forest inventories and ecosystem manipulation experiments. By accounting for trade-offs between different growth strategies and a C cost of nutrient uptake, I will simulate the plant C economy under optimality constraints – a powerful approach, supported by observations but not exploited for DGVMs. The project is conceived to combine the relevant expertise and exploit the pioneering science of leading European researchers with my integrating role and demonstrated model development skills. Collaboration with two secondment hosts will facilitate the mining of their large data resources and fusing data into model predictions using Bayesian statistical tools. This project will integrate new model components developed at my current host institute and will be a crucial step on the way to building the next generation of vegetation models.

Mots clés : climate change, carbon cycle, soil fertility, nitrogen deposition, allocation, biomass productivity, plant soil interactions

Participants :
- CERCA Institution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €
Projet HARBOR (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The fellowship – Healthcare Access in Rural Border Regions. Realizing Patient Rights Across European Borders (HARBOR) – will launch the first cross-national and multi-scalar study of cross-border interactions and their impact on access to healthcare in rural and disadvantaged border areas in Europe. Developing a novel conceptual framework in which borders and cross-border interactions are an integral part of healthcare territories, the project aims to close the gap in regional studies and social policy literature on the provision of health care in European border regions. Building on in-depth data from four countries (Belgium, France, Norway and Sweden) and from the EU institutions, HARBOR will provide new, gender-sensitive, comparative knowledge about how the EU, national, regional and local authorities can ensure quality health care in disadvantaged, rural regions. The project will develop an original analytic framework which will allow scholars to bridge insights from the scholarly literature in comparative health studies and border studies. Access to timely and affordable healthcare is one of the key principles of the European Pillar of Social Rights. The fellowship will produce new knowledge to help make this a reality. The fellowship will identify facilitators of and barriers against cross-border co-operation. The project will additionally make proposals for ways to reconcile territoriality bound social rights and supply planning with cross-border mobility and potential for pooling resource. An experienced researcher (Dr Alban Davesne, France) will collaborate with a centre of gravity for the study of European social policy (Oslo Metropolitan University, Norway) and a leading research centre with international expertise on European health policy (secondment at The European Social Observatory, Belgium) for intersectoral knowledge transfer, career development, and European added value.

Mots clés : eu health policy, eu citizenship, patient rights, regional co operation, centre periphery relations, multiscalar analysis, european pillar of social rights, sustainable development goals

Participants :
- OsloMet – Oslo Metropolitan University (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €
Projet PERSONALMOVE (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The field of animal personality links consistent behavioral variation among individuals to simultaneous differences in life history strategies and fitness. The relative contribution of genetics and developmental processes, such as maternal or individual learning on personality are however poorly understood. The proposal suggests to link animal personality to the field of movement ecology as a new source of data for behavioral studies that allows access to behavioral long term data on long lived wildlife species that was formerly unavailable. Using a unique dataset of multigenerational GPS-relocations, genetic, and dietary data of European brown bears, this research proposal will quantify 1) which portion of personality is determined by genetics and which part by maternal learning, 2) to what degree an animals personality is stable throughout life, and based on that 3) whether behavioral traits measured at earlier stages in life can be used to predict behavior later in life. This will be particularly useful to develop a predictive model of how environmental conditions, maternal behavior and relatedness determine the movement and dispersal behavior of young bears. These behaviors are directly linked with resilience to anthropogenic disturbances as well as population connectivity. In light of expanding carnivore populations across Europe, understanding which individuals are most likely to disperse through anthropogenic landscapes will be critical to successfully mitigate conflicts. The ER will use the latest advances in the field of movement ecology to quantify individual differences in movement strategies among bears. The ER’s experience with the study system, in combination with the supervisors excellence in the field of movement ecology, and the high relevance of the topic for the foreseeable recolonization of parts of Europe by brown bears makes this project of utmost priority.

Mots clés : maternal care, animal movement, personality, dispersal

Participants :
- Leibniz Association (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 159460.8 €
Projet ADVaNCE (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The field of toxicology is evolving from purely descriptive to a highly data‐rich science. To structure this large amount of data and in this way make the usage more effective for the safety assessors, the concept of adverse outcome pathways was established providing a means of understanding how chemicals induce adverse effects through their toxicity pathways and modes of action. However, there are some doubts if the one initiating event - one adverse outcome relationship enforced on AOPs by the OECD guideline is able to cover more complex adverse effects like hepatocellular carcinoma resulting from non-mutagenic chemical exposure. Therefore, the ADVaNCE project will demonstrate based on the just mentioned example that combining all existing knowledge into an adverse outcome network formed by interlinked AOPs is needed to cover all the pathways and intervention points activated in order to contribute to the development of hepatocellular carcinomas. Computational approaches will be used to extract important key events and their relationships from existing data sources and the relevant literature. These will be compared with existing AOPs and further experimental validation will be started. The computational and experimental result will finally guide the development of an integrated testing strategy completely based on in silico and in vitro data, which development and validation regarding regulatory usage will be continued after the project.

Mots clés : risk assessment, adverse outcome pathway, computationally predicted, hepatocellular carcinoma, non mutagenic carcinogens, validation

Participants :
- Edelweiss Connect (Switzerland) (Suisse) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 187419.6 €
Projet ADVANTAG5 (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The fifth generation and beyond radio systems targets 1000 times traffic volumes compared to present state-of-the-art. In order to guarantee the quality of service, communication capacity leap of three orders of magnitude requires sophisticated interference management and communication channel protection from the interference generated by other users. The objective of this project is to develop integrated transceiver hardware structures for massive MIMO/beam forming antenna arrays, supporting agile carrier aggregation, digitally assisted interference management, and full duplex communication, thus enhancing communication efficiency in spatial, temporal and frequency domains. The evolution of communications systems inherently relies on integrated microelectronic circuits. In circuits developed in this project, we will fully exploit the digital-driven process evolution by utilizing digitally intensive time/phase domain signal processing as much as possible to minimize the effect of existing discrepancy between digital-driven process scaling and analog circuit design. The developed structures will take advantage of time/phase domain signal processing, taking full advantage of CMOS process evolution and inherently supporting beam forming antenna array structures. We will demonstrate the effectiveness of design methods by implementing transceiver hardware structures for massive transceiver arrays. Digitally reconfigurable transceiver arrays will enable spatial multiplexing, agile carrier aggregation and digitally assisted interference management to enhance communication efficiency in spatial, temporal and frequency domains, enabling the targeted capacity leap.

Mots clés : integrated circuit, transmitter, receiver, interference, fifth generation communication systems, mimo, antenna array, beam steering, time based signal processing, outphasing

Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Aalto University (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 267793.2 €
Projet Space4Giants (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : TERMINATED

The growth of transportation infrastructure since the turn of the century has been phenomenal and is expected to expand significantly by 2050, especially in Africa and Asia, under the Chinese global Belt and Road Initiative. Despite positives, this growth presents potential adverse outcomes for nature and people, especially in biodiversity-rich nations, such as Kenya. It is expected that the impacts will affect large and charismatic terrestrial giants such as elephants that depend on high mobility and open spaces for climatic and anthropogenic impact adaptation. In Kenya, large and numerous infrastructure projects and rapidly changing land-use systems are found within biodiversity-rich and fragile ecosystems such as the Amboseli-Tsavo Conservation Area in the south-eastern part of the country, hosting Kenya’s largest elephant population. Elephants are important flagship species that significantly influence conservation efforts in many parts of Africa. Understanding the consequences of transportation infrastructure is important for their management and conservation, and securing their spaces and livelihoods depending on the resources in these spaces. The Space4Giants project will assess the impacts and interactions between changing human population, environments, infrastructure, and development at a landscape scale in the recent past and the near future. The findings of this study will support the development of tools and capacity that will provide insight into the socio-ecological-environmental impacts of linear infrastructure in Kenya that will be used to mitigate the impacts nationally with the potential to be applied across the Global South.

Mots clés : transporation infrastructure, standard gauge railway, african elephant, amboseli tsavo conservation area

Participants :
- University of York (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €