Projet INT2ACT (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

In recent years, nucleic acids (NAs) have contributed significantly to advancing the diagnosis and treatment of diseases such as cancer, infectious and rare diseases. Breakthrough technologies like genome editing tool CRISPR/Cas9, direct RNA sequencing, multi-omics analysis procedure for NAs analysis, bioinformatics and machine learning for data analysis, and targeted delivery systems based on lipid nanoparticles (LNPs) prove the increasing interest in NAs applicability. However, the full potential of NAs is yet to be unlocked, and the translation of NAs into clinical practice is still facing many methodological and technological limitations such as low detection sensitivity, limited sequencing capacity, lack of analytical methods for NAs therapeutics, and inadequate in vivo delivery. INT2ACT brings together 6 academic research units and 5 industrial partners to address these limitations by establishing new methods for detecting and analysing NAs in patient liquid biopsies, boosting available procedures for direct RNA sequencing, developing new methods for the synthesis and analysis of antisense oligonucleotides (ASO) libraries, identifying new RNA targets, and optimise NA therapeutics delivery systems. The concept of harnessing NAs in the realm of medicine opens doors to an array of possibilities, including the development of therapeutic vaccines for cancer and innovative ASO-based therapies for addressing a multitude of genetic disorders. While advancing NAs’ research and technologies, INT2ACT will also contribute to forming the next generation of highly skilled experts through an interdisciplinary and intersectoral training programme delivered to 15 Doctoral Candidates. The network-wide training programme is designed to ensure that all INT2ACT fellows will have the skills for a successful career in or outside of research in any sector.

Mots clés : nucleic acids detection liquid biopsies direct rna sequencing antisense oligonucelotides therapeutic nucleic acids delivery personalised medicine mitochondrial dna biotherapeutic production

Participants :
- Baseclick gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 290272.32 €
- Université de Shanghai (Chine) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Accelopment (Switzerland) (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université d'Udine (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 563510.16 €
- Institute of Bioorganic Chemistry, Polish Academy of Sciences (Pologne) — Partner, beneficiary, Recherche, subvention : 251150.76 €
- Université de Southampton (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 348738.12 €
- Université Louis-et-Maximilien de Munich (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- AstraZeneca (United Kingdom) (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Flomics biotech sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 282188.16 €
- Center for ethics in science and science journalism - centro per l'etica nella scienza e nel giornalismo scientifico (Italie) — Partner, associated partner, Autres, subvention : 0.0 €
- University School for Advanced Studies - IUSS Pavia (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Technion - Institut de technologie d'Israël (Israël) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 639154.8 €
- Technion - Institut de technologie d'Israël (Israël) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Italian Institute of Technology (Italie) — Partner, beneficiary, Recherche, subvention : 563510.16 €
- Mana bio ltd (Israël) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Nanovery ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 348738.12 €
- Istituto Nazionale Biostrutture e Biosistemi (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université du Pays basque (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Johns-Hopkins (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University College Dublin (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 341087.04 €
- National Institute for Bioprocessing Research and Training (Irlande) — Partner, beneficiary, Autres, subvention : 341087.04 €
- Université de Newcastle upon Tyne (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Biogipuzkoa Health Research Institute (Espagne) — Partner, beneficiary, Recherche, subvention : 564376.32 €
- Université Pompeu Fabra (Espagne) — Partner, associated partner, Autres, subvention : 0.0 €
- Careers research and advisory centre (crac) limited (the) (Royaume-Uni) — Partner, associated partner, Autres, subvention : 0.0 €
- Oneki ab (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €