Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CoL (Horizon 2020, appel à projets 2020)
Action : MSCA other
Statut du projet : SIGNED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Mots clés : systemic lupus erythematosus, autoimmune neutropenia, attention deficit disorder, administration assistance, disability, assistive equipment, accessibility, travel assistance

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 56372.0 €
Projet DARE (Horizon 2020, appel à projets 2019)
Action : MSCA other
Statut du projet : CLOSED

Request of financial support to cover the additional costs that researchers/staff members with disabilities face due to the increased costs of their mobility and/or to ensure necessary assistance by third persons or for adapting their work environment.

Mots clés : disability, secondment, special needs, researcher mobility

Participants :
- University of Iceland (Islande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 25812.0 €
Projet ORBETEC (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Research related to the fourth Industrial Revolution is growing up and are a major asset for prosperity and European economic growth. However, the effect of human resources management in relation to industry 4.0 remains few investigated in the field of Work and Organizational Psychology. In view of the constantly evolving dynamics favouring the implementation of new technologies in organizations (autonomous robots, virtual reality, big data, and so on), it is now essential to define a model adapted to industry 4.0. The objective of ORBETEC project is to generate a model of human resources management, targeting four essential areas (organizational development, professional development, competence development, and compensation/reward), applied to the reality of industry 4.0. The research will take place in Foligno (IT) in a highly technological organization, the Umbra Cuscinetti S.p.A (Umbra Group headquarters), world leader in the production of recirculating ball screws in the aeronautic sector. Beatrice Baldaccini (Supervisor) and Carlo Odoardi (Professor Key person) will provide researchers’ supervision and training. The use of a qualitative and quantitative methodology via multilevel and longitudinal statistics will allow the study of the organizational behaviours generated inside evolving and highly innovative organizations. Two secondments will be determined in order to strengthen the international and interdisciplinary aspect of the ORBETEC project. ORBETEC will be one of the few researches to explore Industry 4.0 in the field of organizational behaviour and will contribute to the definition of an international human resource management model. The results will be disseminated in peer-reviewed international journals and interdisciplinary training will propel the researcher at European expert level. Finally, ORBETEC will improve the performance, productivity and work-life quality of a company with an economic impact at regional, national and European level.

Mots clés : industrial innovaton, human factor, performance, industrie 4 0, organisational behaviour, new technologies, robotics

Participants :
- UmbraGroup (Italy) (Italie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 168277.2 €
Projet RotaxHEC (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Research towards the development of sustainable energy sources focusses on minimising our negative impact on the Earth. Towards this end investigations into the exploitation of solar power as a clean source of energy are active across multiple scientific disciplines. One approach is to utilise water splitting catalysts to generate oxygen and combustible hydrogen gas from water. This task is often split into the two halves of the problem: the oxygen evolving and hydrogen evolving sides. This project aims at the development of a new class of hydrogen evolving catalysts based on mechanically interlocked rotaxane architectures. The advantages of the proposed catalysts include mechanical protection of the catalytic centre, prevention of ligand dissociation by virtue of mechanical bonding, and assembly of the multi-component architecture in a single, rapid, high-yielding step. Initially rotaxane ligands will be synthesised using the synthetically flexible, convergent, active template (AT) methodology followed by examination of their coordination chemistry with abundant and cheap cobalt. Subsequently these structures will be assessed for their catalytic behaviour using electrochemical techniques, with structural optimisation utilised to improve their activity. We will then append photosensitising units to imbue these systems with photocatalytic activity. This MSCA would allow me to develop my skills as an independent scientist, both in terms of capitalising on the skill set during my studies in New Zealand, combined with gaining new knowledge and practical abilities, as well as enhancing my supervisory, teaching, and project management skills. Furthermore, having obtained my tertiary education (including Ph.D.) overseas, the action would facilitate my reintegration into the European scientific community and provide Europe with a highly skilled, independent scientist ready to take up the challenge of an independent research position.

Mots clés : rotaxane, water splitting, solar energy

Participants :
- University of Southampton (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet CyclAr (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Research work at the University of Manchester (UNIMAN) has developed an efficient synthetic method to prepare arylenevinylene polymers with control of molecular weight and end-group functionality by the ring-opening metathesis polymerization (ROMP) of strained 1,9-cyclophanedienes. The CyclAr project will use this methodology to deliver conjugated polymers of novel topologies, including rings, 8-shapes, trefoils and others. Macromolecular rings will be prepared by ring expansion metathesis polymerization (REMP) using a tethered ruthenium carbene complex and more complex topologies from telechelic polymers prepared from a bifunctional ruthenium carbene complex. Electron rich (p-type) and electron poor (n-type) polymer topologies will be prepared from the appropriate functionalised cyclophanedienes and topological heterojunctions examined. These molecules will be screened for their photovoltaic performance as the novel molecular topologies can lead to an enhanced charge separation and fewer loss mechanisms - key factors in achieving higher power conversion efficiency in OPVs. The synthetic methodology to be adopted is novel and application of these topological arylenevinylene polymers as semiconducting materials in device fabrication is unprecedented. The overall aim of the project is to develop novel topologies for arylenevinylene polymers and to investigate the influence of the molecular shape on the physical, optical and electronic properties.

Mots clés : organic electronics

Participants :
- University of Manchester (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet Edible Neuroprosthetics (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Restoring sensory and motor human functions is the main goal of Neuroprosthetics. The development and integration of artificial devices with neural tissues is therefore a very important research branch, which aims at improving the quality of human life. Recently, many advances have been made in this field by exploiting implantable organic devices able to accomplish a specific task inside the biological environment and last as much as possible before being removed. Within this scenario, the project aims at pushing the current state-of-the-art of Neuroprosthetic further by implementing a concept of ‘Edible Neuroprosthetics’, which consists in bio-electronic devices able to be literally digested by the cellular environment of the host after they have achieved their target. Novel fully biodegradable microelectrode arrays will therefore be fabricated on flexible substrates by implementing highly biocompatible and edible materials with innovative soft fabrication techniques. Their deterioration rate and change in the mechanical and electrical properties will be assessed with in-vitro ageing studies, followed by in-vivo tests in order to supply a proof-of-principle for future clinical applications. The inter-disciplinary and innovative aspects of the project will have a profound effect on the personal scientific background of the applicant as well as on her future career as independent researcher. The new skills she will acquire together with the new techniques she will learn and the wide scientific network she will actively be involved in will contribute to the formation of a strong and versatile research figure in Neuroprosthetics. Moreover, the results will provide unprecedented insight within the edible device concept, therefore making an important breakthrough, which will direct the Neuroprosthetic world towards less invasive bio-implants.

Mots clés : organic bionics, neuroprostheses, bioelectronics, dissolvable neuroprostheses, bioresorbable device

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175419.6 €
Projet DeBoRA (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Rheumatoid arthritis (RA) is associated with local bone erosion and systemic osteoporosis, which leads to severe disability and low quality of life. Although treatment with biologics can reduce bone loss by inhibiting inflammation, biologics are not able to achieve bone repair and some patients do not respond sufficiently to the treatment. Therefore, an efficient long-term therapeutic approach to target bone erosion and osteopenia still need to be established. Here, we describe a possible involvement of the neurotransmitter dopamine (DA) in bone metabolism and how we aim to use this new pathway to control bone erosion and restore bone mass in RA. The involvement of DA on joint inflammation in RA was demonstrated in vitro and in vivo, and an elevated concentration of DA in the synovial fluid of RA patients was also described. Moreover, we recently described that DA is produced in RA synovial tissue and can act in an autocrine/paracrine manner. However, it is still unclear which role local DA can exert on bone erosion in RA. We performed preliminary experiments and could confirm the presence of DRs in RA bone remodeling zone and in osteoblasts isolated from RA. Moreover, DR activation stimulated IL-6. This confirms the active role of local DA also on bone metabolism in RA. Goal of the present study is therefore to elucidate the mechanisms of action of DA in bone remodeling in RA, in order to find out how to modulate this pathway to control bone erosion and stimulate bone formation in RA. Specifically, we will address the following issues: 1) To identify the mechanisms responsible for DRs expression in RA bone remodeling zone, 2) To define mechanisms of action of DRs on bone metabolism in the context of RA 3) To prove the clinical applicability of DA modulation in arthritic joints towards an anti-inflammatory and bone-protective path. Final goal of this project is to establish a new therapeutic approach to block bone erosion and restore bone mass in RA.

Mots clés : rheumatoid arthritis, dopamine, bone remodeling, osteoblasts

Participants :
- Leibniz Association (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171460.8 €
Projet IronFeRhizo (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Rhizobia-legume symbiosis (RLS) is the principal entry pathway of sustainable N in agricultural systems. During the symbiosis, plants develop a new organ called the nodule that hosts thousands of endosymbiotic bacteria expressing the nitrogenase, the enzyme responsible to transform the atmospheric nitrogen into ammonia. The nitrogenase unique metallic cofactors (made of Fe and Mo) likely impose an extra demand of these metals to the cell, which already requires a basal amount of Fe to synthesize ‘housekeeping’ metalloproteins. However, the transport systems required by the endosymbiotic rhizobia to satisfy that increased demand remain obscure yet. In this project, we will combine molecular biology approaches, including cell-labeling, epitope tagging, and loss-of-function genomic approaches coupled with thorough phenotyping and two analytical methods, inductively coupled plasma-mass spectrometry and X-ray absorption spectroscopy, to characterize how much iron does nitrogen-fixing bacteria need, how much is used to metallate the nitrogenase and other metalloproteins, and what genes are required to maintain the Fe homeostasis in the endosymbiotic bacteria. The methodologies developed within this project will open new avenues for the study of mineral nutrition in other soil bacteria and will offer an insight into how cells partition an element among different metalloproteins. Furthermore, ironing out Fe homeostasis in rhizobia will allow us to maximize the nitrogen fixation capabilities of both natural and synthetic nitrogen-fixing bacteria to be used as inoculants in sustainable agriculture practices.

Mots clés : fe homeostasis, metalloproteome, epitope labelling, icp ms, xanes, exafs, facs, rhizobium leguminosarum, rhizobia legume symbioses, biological nitrogen fixation

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet RHOMBOSMALPS (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Rhomboid proteases from P. falciparum, the causative agent of malaria, play a role in invasion of human red blood cells. The exact role of the individual members is challenging to track, because of difficulties in genetic manipulation of the P.falciparum and the inviability of some loss-of-function mutants. Hence, a chemical strategy is an attractive alternative. Unfortunately, the study of these eukaryotic rhomboids (PfROMs) has rendered impractical to date. The bottleneck is that the current purification techniques use detergents that eliminate the physiological membrane, yielding low enzyme stability and activity. In its turn, this rules out the use of activity assays and chemical probes to study their function. Encapsulating these proteins in their lipid environment will address these shortcomings. I will develop a detergent free purification method, based on a styrene maleic acid (SMA) polymer that functions as a “molecular cookie cutter”, creating SMA-lipid-protein nanodiscs, which retain their biological properties upon purification. Using this “molecular cookie cutter” to create lipid nanodiscs, I will isolate PfROMs and develop activity assays in order to identify and optimize novel inhibitors. The most potent and selective candidates will be evaluated in a malaria invasion model to verify the druggability of malaria rhomboids. Furthermore, these novel compounds may serve as leads for a new generation of therapeutic agents. The straightforward expansion of our approach to other intramembrane proteases may be the game-changer for drug discovery and future therapeutics directed against rhomboids from other species.

Mots clés : intramembrane proteases, rhomboid, malaria, styrene maleic acid lipid particles, activity based protein profiling

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €
Projet MULTIPIR (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

River pollution has become a serious environmental problem in the Europe and worldwide as it dramatically affects the freshwater quality and human health. A major source of chemical and physical pollution in rivers is small particles known as fine-grained sediment (FGS). Intensified agricultural practices and the associated increase in soil erosion in Europe has caused a shape increase in the supply of FGS to water streams. Consequently, the water quality in many rivers in Europe have deteriorated and are failing to meet minimum water quality standards. Hence, there is a urgent need to address the river pollution problem through a thorough understanding on how much supplied FGS infiltrates into the river bed and how much is resuspended and migrated at different hydrodynamic conditions, i.e. the dynamics of FGS. MULTIPIR takes an inter-disciplinary approach to tackle this challenge heads-on by combining the extraordinary experience of the researcher in erosion, sand production, hydraulics and computational fluid dynamics (CFD) with the expertise of the supervisor in coupled discrete element methods with CFD (DEM-CFD) and solid-liquid flows. A combined experimental and numerical investigation on the migration of FGS in the river will be performed, from which multiscale models will be developed to predict the infiltration and re-suspension of FGS at the microscopic level and the transport of FGS at different hydraulic conditions at the macroscopic scale. Using the developed model, a river pollution control map will be developed to guide the river managements. It is for the first time that advanced engineering approaches, e.g. DEM-CFD and advanced imaging techniques, are employed to address the challenging environmental problem and to develop a science-based river pollution control strategy that can benefit European citizens and beyond.

Mots clés : river pollution, discrete element method, dem cfd, erosion, particle technology

Participants :
- University of Surrey (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet RENEWABLE-HIGH-SEAS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Roughly 64% of our oceans are marine areas beyond national jurisdiction (ABNJ), i.e. the international seabed area (Area) and the high seas. This extensive area has unparalleled potential for the use of marine renewable energies (MREs) to provide energy security and competitiveness (i.e. creation of jobs and economic development) to the States as well as for the fight against climate change at a global scale. Accordingly, States are becoming increasingly interested in the economic and climate change mitigation potential in ABNJ. At the same time, however, the expansion of MREs into marine ABNJ as well as the environmental impacts associated with their development can entail new risks and threats to security and biodiversity due to the significant regulatory challenges and governance gaps in ABNJ. This project aims to enhance the sustainable development of MREs in ABNJ in a global and European regional context. To achieve this, the project will analyse the ability of the global and European regional regulatory frameworks for the development of MREs and the protection of the environment related to their development in ABNJ, as well as will explore new forms of governance through global energy agencies (IRENA and IEA). As a result, this project will shed light on normative questions related to governance, sovereignty and policy-making considering global and regional forms of governance of MREs in ABNJ, which will significantly contribute to advancing and strengthening the renewable energy and related environmental governance in ABNJ as well as to opening-up discussions and debates on this issue within academics, state officials negotiating the UN treaty for the conservation and sustainable use of marine biodiversity in ABNJ, professionals, the MRE industry and the wider community.

Mots clés : marine renewable energies, areas beyond national jurisdiction, law of the sea, environmental law, regional and global governance

Participants :
- University of Jaén (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet PESTEFFECT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Résumé: The reduction of environmental and health risks from pesticide use is a major challenge for agriculture and on top of the agricultural policy agenda. Despite substantial efforts, current pesticide policies have not reached their reduction targets. Recent research shows that targeting farmers’ application behavior could be key for advancing pesticide policies. However, our theoretical understanding of the farmers’ decision-making process is limited and empirical studies on the main drivers of inefficient decisions are missing. The interdisciplinary PESTEFFECT project will i) advance our understanding of farmers’ pesticide use decisions, ii) quantify impacts of the main drivers of inefficient decisions, and iii) identify risk reduction potentials on a regional level. In the project, we will i) develop a conceptual and empirical model of farmers’ pesticide use decisions that integrates concepts from agricultural economics, agronomy, and ecology, ii) provide the first empirical analysis of economic and environmental effects of inefficient pest management decisions using an econometric model and iii) provide temporally- and spatially explicit assessments of risk reduction potentials on a regional level using multi-layered maps. For our analysis, we will use a unique, long-term dataset on farmers’ management decisions, environmental conditions, and biodiversity (losses) from Western France. Results will support the development of pesticide policies targeting inefficient pest management decisions and the creation of guidelines for farmers and farm advisors. The project will thus contribute to a more sustainable agriculture in Europe.

Mots clés : agricultural economics, pesticides, environment and health risks, farmers  behaviour, risk reduction, pesticide policies, sustainable agriculture

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 184707.84 €