Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet The G-Q-reat ESKAPE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The antimicrobial resistance (AMR) is an underrated problem promoted by widespread misuse and massive use of antibiotics. Thus, the health systems are facing enormous costs to treat nosocomial infections due to AMR bacteria. In particular, six highly virulent bacteria (E.S.K.A.P.E.) are the main responsible for worldwide nosocomial infections. In the last years, our research strategies to discover and develop new clinically relevant antibiotics lacked effectiveness. As a result, we are unable to efficiently treat AMR infections and are unprepared to face an AMR bacteria outbreak. One possible strategy is to target bacteria G-quadruplexes (bGQs) which are highly conserved DNA/RNA secondary structures pivotal for bacteria duplication, transcription and translation. This strategy is particular effective because, when a new pathogen emerges, its DNA/RNA genome is first disclosed through sequencing, hence the ability of quickly designing new drug candidates based only on this information will be a powerful tool to face a new epidemic/pandemic. Furthermore, the human GQs (hGQs) were largely investigated as possible target for anticancer treatment thus the interest in bGQs raised later and with less intensity than hGQs. In addition, most GQs modulators bind G-quartets top by π-stacking interactions and the druggability of GQs loops/grooves was still not addressed. In this context, the multidisciplinary of G-Q-reat ESKAPE project aims to provide a novel and effective strategy to contrast AMR by targeting bGQs and to expand the knowledge on bGQs.

Mots clés : g quadruplex, antimicrobial resistance, in silico screening, molecular dynamics, biophysics

Participants :
- Université de Sienne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet SonoNeuroS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The neurodegenerative diseases and neurological disordered in Central nervous system (CNS) are increasingly recognised as major causes of death and disability in the world, which eventually treatment cost is about €800 billion per year. The main reason behind the non-existence of efficient treatment is that unlike young neurons, mature neurons from the CNS lose the ability to regenerate their axons after injury. To understand the detailed mechanisms, remain not only unknown in Neuroscience but represents also a major challenge for public health and society. Neuro-stimulation is technique that stimulate the activity of neuron and provides solutions to fill the knowledge gap. Current neuro-stimulation techniques somehow limited to large neuron brain areas, rely on wires to powering system, and suffers from rejection by body inflammable. The emerging wireless and battery-free technologies based on ultrasonic communication allows to remove electrode connections to external source. The overall goal of SonoNeuroS project is to develop proof of concept of a fully wireless ultrasound-based powering of electrical stimulation technique with in sub-mm range with diamond electrode materials. This research proposal aims to develop and validate the proposed stimulators for sufficient amount fully wireless power communication, battery free with shrinking size for implantable within 100 µm. We will use diamond due to interesting properties for chronic implantation is its high resistance to corrosion, very good biocompatibility. In this idea combining ultrasound powering with Piezoelectric Micro-Machined Ultrasonic Transducer (p-MUT) technology to diamond electrodes, in order to reduce the size results at a smaller scale axial resolution of single neuron activity. After develop wireless neural stimulators, we will have used it to study the effect of electrical stimulation on output of retinal ganglion cells (RGCs), which provides new way towards to visual prostheses.

Mots clés : ultrasound, electrical stimulation, instrumentation, micro fabrication, neuro stimulation

Participants :
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
- Université Gustave Eiffel (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PLANETDISKOS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The intricate processes governing the birth of planets take place inside gaseous protoplanetary discs around young stars. When planets grow beyond Neptune in mass, their gravitational influence perturbs the gas density in their vicinity, creating pressure bumps or shallow gaps that effectively halts the inward drift of millimetre to centimetre-sized dust aggregates, often referred to as pebbles, from the outer reaches of the disc. Consequently, pebbles accumulate at these pressure bumps, creating dust rings observable through observatories such as ALMA. Classical numerical simulations of planet formation frequently assume a monodisperse pebble size distribution, contrary to revelations from prototoplanetary disc observations, where pebbles come in various sizes and compositions, influencing the dynamics of planet formation. The PLANETDISKOS project aims to develop a comprehensive model that considers grain size evolution and pebble filtration by gas giants, while accounting for variations in pebble composition and porosity. A novel methodology is proposed to model self-consistent grain size evolution and pebble filtration by gas giants. This approach promises to enhance our understanding of the prevalence of Super-Earths in the presence of outer Jupiter-like planets and the heavy element content of gas giants. Synthetic exoplanet simulations will be conducted, integrating compositional properties, to compare with observed exoplanet populations. Early results from my numerical simulations of pebble filtration demonstrate the potential to achieve the goals of the project. Working with a team of experts in planet formation and cosmochemistry at StarPlan, I will acquire the needed skill set to execute the PLANETDISKOS project, opening new avenues for advancing the theoretical framework of (exo)planet formation.

Mots clés : hydrodynamics, pebble accretion, planet formation, gas giant planets, protoplanetary disc evolution

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet SDQI (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

This project in pure mathematics aims to solve problems in symbolic dynamics (a mature branch of dynamics with important connections to coding theory, information theory, and operator algebras) using tools from the modern theories of quantum information and quantum groups. The central challenge dating back to at least the 1970s is to classify symbolic dynamical systems. My proposal pioneers a highly interdisciplinary and novel approach using the uniquely quantum phenomena of ‘entanglement’ and ‘noncommutativity’ as they appear in quantum information/quantum groups. The main objective is therefore to establish a fruitful connection between symbolic dynamics, quantum information theory and quantum groups to the benefit of all three communities. The proposal is based around two central open problems: how do we classify symbolic systems, and what are the symmetries of symbolic systems? A novel approach to these problems builds on the recent advances made in part by the supervisor that connect graph theory with quantum information/quantum groups. I introduce a new nonlocal game (the Conjugacy Game) that will define ‘quantum conjugacies’, and a notion of quantum automorphism that will define ‘quantum symmetries’ of symbolic systems. This marks the first interaction between quantum information/quantum groups and symbolic dynamics. The ideas are therefore very timely, will have high impact, and set a precedent for future uses of quantum mathematics in other domains and specifically other classes of dynamics (e.g. multidimensional subshifts and algebraic actions). The fellowship will strengthen my academic career via the opportunity to learn new tools in quantum mathematics and apply them to solve important problems in dynamics. It will also allow me to establish new collaborations with leading experts in dynamics and quantum information/quantum groups that will play a key role in my goal of obtaining a permanent academic job and an investigator grant to build a research g

Mots clés : symbolic dynamics, quantum information theory, quantum groups, operator algebras

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet CROW (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

CROW explores lay experiences of being mentally unwell in 16th- and 17th century Scandinavia. It asks how social status, gender and age affected experiences of mental states before the modern era. In doing so, it deepens our understanding of mental suffering historically and creates an inclusive and complex history of the phenomenon. The project uses new sources and new digital methods that combined can reach a wide variety of experiences. The objectives of CROW are: 1. Provide an examination of experiences of being mentally unwell in the early modern period that takes into account embodied experiences and emotions as well as early modern religious and medical frameworks; 2. Advance the scope for examining lay people’s experiences through the use of digital methods; 3. Provide a historical account of experiences of mental suffering that informs present-day debate about mental health. CROW uses as a point of departure the understanding that experiences are created through embodied sensations in cultural contexts, and thus socially bound and historically significant, to argue that they can be researched through patterns in individual statements regarding embodiment, in tandem with reconstruction of cultural frameworks. The project examines ecclesiastical court records from the Scandinavian realms to find patterns in verbatim text concerning embodied sensations. These patterns are examined in relation to descriptions of melancholy in religious and medical vernacular texts aimed at a lay audience. Through the use of software in several steps, the examination moves from the concept of melancholy, which is key to understanding mental suffering in the early modern, learned debate, to the descriptions of embodiment, which means that experiences of mental suffering can be found even when the concept of melancholy is absent. In addition to advancing understanding of early modern mental suffering, this approach will contribute theoretically to the history of experience.

Mots clés : history of experience, history of emotions, mental suffering, early modern

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet SwimmingGiants (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Nearly all galaxies in the universe harbor a super-massive black hole (SMBH)---with mass a million to a billion times that of our sun---in their core. When these galaxies merge, their super-massive black holes are brought together to form a super-massive black hole binary that interacts with the newly forming galaxy's stars and gas. A cosmic population of these super-massive binaries is hypothesized as the source for the gravitational wave background (GWB) detected for the first time this June. The full evolution and ultimate fate of these binaries, however, remains one of the most enduring mysteries in astrophysics. A key element to revealing the destinies of these binaries and unlocking their multi-messenger observational prospects is to understand their late-stage interactions with ambient gas in the nascent galactic nucleus. In the proposed research program, I will deploy state-of-the-art hydrodynamics simulations of the mutual interaction between compact super-massive binaries and their gaseous environments to develop cutting-edge models of gas-driven binary evolution and its associated observational signatures. These models will be essential to current and forthcoming electromagnetic and gravitational wave observations as the GWB detection (and upcoming LISA mission) open the floodgates on the next-generation of multi-messenger astrophysics and cosmology with super-massive binaries; just as the first LIGO detection did for their stellar-mass counterparts 8 years ago. The Niels Bohr Institute in Copenhagen is the ideal location for me to pursue this research program because of their long-standing history and expertise in numerical hydrodynamics, astrophysical gas dynamics, and gravitational wave phenomena; and the Marie Curie Fellowship would enable substantial development of my skills as a researcher, educator, and communicator in order to achieve my goal of eventually leading an independent research group as a professor.

Mots clés : accretion phenomena, binary black holes, gravitational waves

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet Prosec.co (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In the ancient Greek poleis, the prosecution of crimes against the community was largely entrusted to volunteers. Voluntary prosecution (VP) was therefore one of the key elements of the administration of justice in these societies. It is also an institution that, despite being often linked to classical Athens and to democratic ideology, is found in different places, periods, and political regimes. By combining the analysis of literary and epigraphic sources (6th–2nd cent. BC) with a cutting-edge multidisciplinary approach at the intersection of sociology, legal theory, and theory of emotion, this project aims to provide the first comprehensive history of VP in ancient Greece—of its ideological tenets, its institutional framework, and the normative expectations of the community around it, both in and, especially, outside of Athens. I will achieve this aim through three objectives: a) mapping the use of VP in ancient Greece by producing an online database of laws and decrees related to VP, with visualisation of the material through an interactive online atlas; b) drawing a sketch of the different identities and possible motives of volunteer prosecutors, and of how their interactions with VP, with one another, and with the community both shaped and was shaped by a shared internalised set of values and standards of behaviour that was fully institutionalised; c) analysing the emotional components of VP, and how they had an impact on societal attitudes and institutional arrangements related to VP. Prosec.co will place VP in the wider context of voluntarism in the ancient Greek world, and take into account the different perspectives of the individuals that were involved with it, from wealthy citizens to foreigners, down to the poor, women, and enslaved individuals. This will advance not only the scientific debate around ancient Greek society, culture, and institutional design, but also contemporary discourse on private initiative, voluntarism, and civic engagement.

Mots clés : ancient greece, voluntary prosecution, history of emotions, civic engagement, private initiative, democracy

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet FundBHspec (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Gravitational Wave (GW) astronomy has emerged as a fundamental field, allowing us to probe gravity in its strongest regime. Black hole (BH) spectroscopy is a highly effective method for extracting spacetime information from observed GW signals. The late-time radiation of newly formed black holes is characterized by an exponentially damped, oscillating signal. Measuring the decaying scales and oscillating frequencies — the so-called quasinormal modes (QNMs) — offers insightful information about the black hole's background. Therefore, QNMs and BH spectroscopy are crucial in astrophysics, gravitational physics, and mathematical relativity.  The goal of this project is to combine mathematical relativity, numerical relativity, and astrophysics to advance the fundamental theory of BH spectroscopy. Theoretical predictions indicate that small perturbations around a black hole can drastically change its QNM spectra. Thus, in dirty environments, QNMs may deviate from the values expected for isolated BHs. Modern tools from differential geometry and high-accuracy numerical methods allow us to understand this QNM instability. This project will provide a solid theoretical foundation, which integrated into the efforts to measure QNMs, will optimise the scientific gains from BH spectroscopy in the upcoming era of high-accuracy GW astronomy.  The applicant has solid expertise in the mathematical fundaments of general relativity. With the MSCA fellowship, the applicant will enhance her knowledge of fundamental aspects of BH spectroscopy thanks to the expertise of the Niels Bohr Institute (NBI), University of Copenhagen. The Strong group at NBI is composed of leading researchers in the area, providing the perfect environment for this multidisciplinary project. An academic secondment at the University of Texas at Austin will consolidate the acquired knowledge and ensure the project’s impact on key stakeholders, such as the Ligo-Virgo-Kagra collaboration and the Lisa Mission.

Mots clés : black holes, gravitational waves, general relativity, conformal methods, black hole spectroscopy, gravity, quasinormal modes

Participants :
- Université du Texas (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet Listening Audible (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This research addresses the idea of sharing someone's listening to access inaudible aspects of listening experience. By conducting creative and analytic processes I seek to reveal a sonic knowledge that can only be achieved through bodily and sensitive experience. Investigation starts with an epistemological discussion about the material and relational aspects of listening. Then, a methodology is presented to approach non-verbal forms of knowledge within the creative domains of music and sound art, enabling the emergence of a sonic thinking supported by imaginations, desires and affections. The proposal is developed through a systematic investigation based on four interconnected phases. The first phase –Conceptual– refers to an epistemological discussion about listening as a form of knowledge. In the second phase –Diagrammatic– I depart from an exercise involving individual and collective listenings of a heterogeneous set of records of women's voices. This will lead to the creation of an ‘inventory of listening’ developed by participants of a first workshop and myself. The third phase –Creative Sonification– is based on conducting a second workshop and interviews in which art students are encouraged to reproduce and share their listening experiences. The results of phases 2 and 3 will provide material for empirical and comparative analysis in the fourth phase. This Analytical phase will embrace elements that cannot be easily systematized or objectively described, such as personal impressions, insights, bodily actions and sensations. The main idea is to explore non-verbal forms of knowledge that can stimulate the development of engaged artistic production and foster the construction of individual's identity, plural narratives, and forms of self-awareness expression. It will also contribute to the current debate on how contexts, materiality and subjectivities can reflect on the power relations - political, economic, and social - implicit in the process of listening.

Mots clés : listening, sound studies, sound art, arts based research, noise, sonic epistemology, sonic thinking, creative research, qualitative methods, creative process, voice

Participants :
- Q-o2 (Belgique) — Partner, associated partner, Autres, subvention : 0.0 €
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 288468.0 €
Projet LC-NanoCoat (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Orthopedic implant-associated biofilm infections represent a major public health and socioeconomic burden due the intrinsic tolerance of biofilms that behave as protective and immobile scaffolds to conventional antibiotics and immune system. Further, their long-term and repeated antibiotic treatments lead to an increased potential of antibiotic resistance development. Here, this interdisciplinary proposed project integrates innovative aspects of surface chemistry, 3D morphological characterization of coated implants, and precision engineering with attributes for production of much needed biofilm-targeting nanostructural implant coatings. It also considers the urgent societal needs for introducing an effective, flexible, and universal approach in orthopedic implant patterning and functionalization for combatting and preventing implant-associated biofilms. This core approach is based on controlled patterning with inverse non-lamellar lyotropic liquid crystalline phases having unique nanostructural versatility through prior precision priming of new 3D porous implant surfaces with tailor-made coating method, and their thorough characterization by using different modalities including GISAXS, neutron reflection, high-resolution X-ray photoelectron spectroscopy, and X-ray micro-computed tomography. This is in combination with in vitro profiling on model implant-associated biofilm infections. The project provides an environment with independent research activities for building my professional skills in a research topic at the interface of nanoscience, surface chemistry, and experimental medicine. In addition to training at different synchrotron facilities, my research career will be certainly advanced owing to the gained experience with state-of-art biophysical tools and supervision of Master students.

Mots clés : antimicrobial coatings, biofilm infections, inverse non lamellar liquid crystalline phases, in vitro evaluations, orthopedic implants, surface modification, x ray micro computed tomography

Participants :
- Université de Newcastle upon Tyne (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University Medical Center Utrecht (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €