Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Mem4BIOCH4 (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Biogas from the anaerobic digestion of organic waste and wastewater is regarded as one of the most promising renewable energy vectors to partially address the current global environmental and energy challenges. However, CO2 and H2S, along with other biogas pollutants, need to be removed to enlarge the scope of biogas applications. Membrane technology is currently undergoing a rapid development driven by the synthesis of new polymer materials with promising properties and enhanced performance, and is set to play an increasingly important role in reducing the environmental impact and cost of industrial biogas upgrading. Mem4BIOCH4 aims at fostering industrial biogas upgrading by engineering low-cost and efficient membrane modules based on innovative polymer materials with superior gas separation performance in order to enhance biogas valorisation via production of high-quality biomethane. Mem4BIOCH4 will focus on overcoming the current limitations of membranes in order to support a low-cost upgrading of raw biogas via CO2 and H2S separation using novel polymer materials. In addition, emphasis will be also put on the CO2 and N2 separation from biogas produced in the anaerobic digestion of domestic wastewater, which has not been assessed to date to the best of our knowledge. This multidisciplinary action will have a significant impact in fields such as chemistry (novel monomers with specific structural features), materials science (new polymers with enhanced properties), environmental technology (more sustainable biogas conversion technologies), and economy (low-cost biogas upgrading fostering the biomethane market). Mem4BIOCH4 will bring multiple environmental and economic benefits to society, facilitating the creation of a sustainable and cost-competitive biomethane industry in Europe. This action will be carried out at Valladolid University, with secondments at University of Twente and Biothane (Veolia Water Technologies).

Mots clés : biogas upgrading biomethane gas separation membranes ultrapermeability polymer membranes

Participants :
- Biothane systems international bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Twente (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Valladolid (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Valladolid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet ReCHISVac (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Schistosomiasis is a neglected tropical disease afflicting over 200 million people and causing 300,000 deaths in Africa alone. Whilst infections can be cleared with schistosomocidal drugs, individuals will become rapidly re-infected upon exposure to contaminated water. Partial immunity only develops naturally only after decades of constant infection, and there is no vaccine. Previous schistosome vaccine studies have been flawed, due to a lack of understanding of what constitutes a protective immune response, focus on single antigen targets, and a lack of pharmaceutical industry support or expertise for development. Here, I propose to use unique samples from repeat Schistosoma mansoni controlled human infection (Sm-CHI) models to reveal novel antigens and corresponding cellular and cytokine responses that are protective against schistosomiasis. To evaluate how well this protective signature will translate to endemic countries, matched analyses will be performed in samples from naturally schistosome infected Ugandan individuals. Antigen-specific antibody and cellular immunology data will be combined utilising bioinformatic tools to reveal a signature of multiple antigens and immune responses associated with protection from schistosomiasis. Next, in a non-academic placement at Batavia Biosciences, I will develop a pre-clinical development plan to translate the identified protective immune signature into an effective vaccine against human schistosomiasis. This fellowship will form the basis of my future career development, to become an independent researcher in the field of schistosome vaccinology.

Mots clés : schistosomiasis, controlled human infection, antigen discovery

Participants :
- Batavia Biosciences (Netherlands) (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Leiden University Medical Center (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 234530.4 €
Projet target4ROS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Cancer therapy faces significant challenges due to multidrug resistance (MDR), which reduces the effectiveness of chemotherapeutic agents. A key factor influencing MDR is the altered redox state within cancer cells, characterized by varying levels of reactive oxygen species (ROS). Understanding the dynamics of ROS is crucial, as they can both promote and inhibit tumor progression. Glioblastoma, a highly aggressive and treatment-resistant brain cancer, exemplifies the challenges associated with MDR, often exacerbated by a hypoxic tumor microenvironment and elevated ROS production. This project aims to investigate the role of ROS in MDR by integrating PhotoActivated ChemoTherapy (PACT) and recombinant D-amino acid oxidase (DAAO), a chemogenetic tool that is able to generate hydrogen peroxide (H2O2), the most stable ROS, within specific cellular compartments. PACT is an innovative anticancer treatment utilizing ruthenium-based (Ru) compounds that are selectively activated by red light in an O2-independent manner, minimizing damage to healthy tissues.  In this project, I will implement DAAO to introduce controlled levels of H2O2 into glioblastoma cells, and then treat the cells with PACT, targeting NAMPT, a protein involved in the recycling of NAD+. I will correlate cancer cell resistance to PACT treatment with ROS levels, which will be monitored via Genetically Encoded Fluorescent Indicators (GEFIs). The project includes i) developing targeted ROS generation systems during a secondment at the nearby hospital, ii) exploring cellular adaptive responses, and iii) conducting in vivo mouse studies to validate the results from in vitro experiments. This project aims to combine chemogenetic applications and PACT for the first time. This innovative research has the potential to provide significant insights into the role of ROS in cancer therapy resistance, and to propose effective strategies to overcome MDR, thereby advancing glioblastoma treatment.

Mots clés : photoactivated chemotherapy, ros, multidrug resistance, cancer, glioblastoma, ruthenium, chemogenetics, genetically encoded fluorescent indicators, proteomics, real time imaging, cytotoxicity

Participants :
- Université de Leyde (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 232916.16 €
- Leiden University Medical Center (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Phenols4Health (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Olive oil is the main fat source in the Mediterranean Diet (MD). The healthy properties of extra virgin olive oil (EVOO) are associated with a balanced composition between major and minor compounds. Among the minor fraction, phenolic compounds (PCs) stand out in terms of their health promoting properties. PCs are responsible for the only specific health claim for olive oil, recognized by the European Food Safety Authority (EFSA), indicating that PCs in olive oil contribute to the protection of blood lipids against oxidative damage. Furthermore, due to their antioxidant capability, PCs are anticipated to exert inhibitory effects on the formation of pro-oxidant species, including advanced glycation end-products (AGEs), which play a pivotal role in oxidative stress and inflammation-related pathologies. Phenols4Health aims to elucidate the health benefits of foods processed in EVOO through the transference of PCs and their potential to inhibit the formation of dietary AGEs (dAGEs). A comprehensive investigation will be conducted to assess the transference of EVOOs' PCs into foods of diverse compositions. This proposal will also explore the influence of the PCs' profile in blocking the formation of AGEs in foods processed with EVOO. Finally, the study will evaluate the profile of AGEs in serum samples collected from individuals adhering to a MD supplemented with EVOO and a low-fat diet. The methodology required for Phenols4Health is based on the use of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for determination of the targeted species. The outcomes of this proposal hold the potential to make a profound impact at scientific, societal, and economic levels. By advancing the understanding of EVOO's health-enhancing properties and its role in inhibiting the formation of dAGEs, Phenols4Health will contribute to food science, nutrition, chemistry, and health fields, while fostering economic opportunities within the olive oil industry.

Mots clés : extra virgin olive oil mediterranean diet antioxidant properties health claim lc ms ms advanced glycation end product

Participants :
- University of Córdoba (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
- Université d'État de Campinas (Brésil) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet EDIOM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Inflammatory Bowel Disease (IBD) is a collective term for bowel diseases caused by undesired immune reactions and can currently not be cured. To develop adequate treatments for IBD, we need to understand the nature and cause(s) of the pathogenic immune responses observed.  To identify mechanisms driving IBD in humans, we need apart from diagnostic correlative studies, adequate in vitro cell models that realistically recapitulate the in vivo situation and allow for intervention studies. Thus far, in vitro models that incorporate next to intestinal epithelium also supportive stroma and immune cells are lacking. In my PhD studies, I generated a map of the IBD-associated immune cell network by single-cell analyses of healthy and IBD patient samples. In my postdoctoral work, I have developed an Air Liquid Interphase (ALI) intestinal organoid platform derived from human samples that supports tissue-resident immune cells.  In this project, I aim to identify cellular and molecular networks driving IBD by diagnostic and intervention studies in intestinal ALI organoids. For this purpose, I will: 1) Validate ALI intestinal organoids as accurate ex vivo model by analyzing their immune cell composition and functionality in spatial context; and 2) aligning this with the in vivo situation by data mining of public single-cell RNA-seq of inflamed intestines. 3) Integrate datasets generated in 1-2) to reveal cellular and molecular immune cell interactions associated with IBD; and 4) Implicate interactions identified under 3) in driving IBD by molecularly targeted interventions in ALI organoids. The proposed work will take place at host institute Leiden Univ. Medical Center, with a 4-month secondment phase at Technical Univ. Delft.  This project is expected to deliver insight into immunological mechanisms driving IBD and clinically translatable therapeutic interventions, by mechanistic studies in a novel in vitro system mimicking the in vivo cellular environment of human IBDs.

Mots clés : inflammatory bowel disease, crohn s disease, ulcerative colitis, air liquid interface organoids, immunology, human immunology, mucosal immunology, systems immunology, data integration

Participants :
- Université de technologie de Delft (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Leiden University Medical Center (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
Projet POL-LOV (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

At a time when migration is increasingly reduced to an object of state security, POL-LOV focuses on the legal, political, and, most importantly, affective relationship between state institutions, especially those in charge of migration, and migrants who are married to European citizens and who seek to regularize their legal status. Through the paired case of Spain and Italy (southern border countries in the EU) and the United Kingdom (a country that recently left the EU), POL- LOV addresses the following empirical research questions: How do state bureaucracies scrutinize, evaluate, and quantify “love” in their decision-making processes about marriage migration? How do marriage migrants, especially women, experience these bureaucratic encounters? By addressing these research questions, POL- LOV pursues two main objectives: 1) advancing social science theorizing about the role of emotions, especially “moral emotions” , in how state institutions operate; and 2) improving our understanding of how the everyday encounters of marriage migrants with state bureaucracies affect meanings and practices and performances of romantic love across borders. POL-LOV is highly original and ambitious in its research design as it develops an interactional perspective focused on the relationships between the state and marriage migrants . The methodology involves capturing state moral emotions through the classic anthropological tools of ethnography: in-depth interviews, participant observation and semi- structured interviews. In practice, this means interviewing policymakers, lawyers and officials in embassies, police headquarters and migration offices. Since there is a methodological focus on both sides of the encounters (state bureaucrats and migrants) I will also do participant observation and in- depth interviews with marriage migrants and its partners and see how they navigate state suspicion and scrutiny.

Mots clés : ethnographic methods, marriage migration, sociology of emotions, migration studies, legal anthropology

Participants :
- Université de Newcastle upon Tyne (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Bologne (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Rovira i Virgili (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet COSINE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The main goal of my proposal is to exploit Compton scattering in PET imaging, a nuclear imaging technique well-established in clinical routine, mainly in oncology as a tool for tumor diagnosis and monitoring, but also through preclinical PET as an essential tool for pharmacology and drug development. By considering signal events undergoing Compton scattering, I expect to increase the sensitivity of PET systems, and so improve the attainable image quality. Sensitivity in PET systems is a key parameter to be optimized, as it could allow for dose exposure and/or scan time reduction, in addition to being critical in low-count regime scenarios, for pediatric patients, and in research applications involving small-animal imaging. Aside from increasing the sensitivity, the purposeful detection of Compton scattering in PET imaging opens the door for the use of this modality for new applications (e.g. immunoPET, theranostics...). However, incorrect/simplified modeling of these events can degrade PET image quality. My proposal relies on developing algorithms and models based on solid mathematical and physical foundations, able to include events involving Compton scattering into dedicated reconstruction frameworks. To this end, I intend to use the knowledge I have acquired during my PhD developing similar models and algorithms for imaging with Compton cameras. Specifically, I intend to address three questions: first, the inclusion of inter-crystal scatter events with particular focus on small-animal PET imaging; second, the modeling of object scattered events and their use in low-count regime scenarios; and third, the treatment of coincidence events that involve an additional emission of photons, either correlated or uncorrelated to the positron emission. The evaluation of the proposed methods will be carried out using both Monte-Carlo simulations and experimental PET data, for which the facilities and technologies developed by the host team in Lübeck will be employed.

Mots clés : positron emission tomography pet , inter crystal scatter ics , object scatter correction, compton camera, low count regime, theranostics, image reconstruction, monte carlo simulations

Participants :
- University of Lübeck (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202125.12 €
Projet AAR-ATB (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The proposed project involves Dr. Andrew Murphy (The University of Chicago) as the researcher and Prof. Dr. Doreen Georgi (University of Potsdam) as the supervisor. The project title is ‘Argument asymmetries revisited: Variation in parallelism constraints on ATB-movement’. This project will investigate the phenomenon of parallelism conditions in so-called Across-the-Board dependencies. On the empirical side, the project aims to broaden the empirical base through a comparative study of tolerable mismatches between argument types in ATB-constructions on the basis of three languages (English, German, Polish) that also takes into account the role of variation. On the theoretical side, the project will incorporate these findings into a general theory of cross-linguistic argument asymmetries involving movement, a goal which has not yet been seriously pursued in contemporary syntactic research.

Mots clés : syntax, syntactic theory, generative grammar, movement, variation

Participants :
- Université de Potsdam (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet MemoryRNA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : TERMINATED

Plants live in constantly changing environments and the increased frequency of extreme weather, as a result of climate change, will exacerbate such stresses. The MemoryRNA project aims to expand the fundamental knowledge of non-genetically-based regulations of the plant transcriptome during heat stress (HS). Post-transcriptional modifications of RNA create an additional layer to reversibly control RNA fate. The sophisticated and poorly understood thermomemory phenomenon represents a powerful system to study the role of the RNA modifications and its high impact on RNA metabolism to reprogram the transcriptome, thus leading plants to adapt and survive. To unravel the role of epitranscriptomic-based reprogramming of the transcriptome of thermomemory RNAs at the shoot apical meristem, the project aims to: i) Reveal the m5C and m6A modifications transcriptome-wide that actively contribute to the global cellular response to HS; ii) Characterize the m5C and m6A marks on thermomemomery mRNAs; and iii) Determine how a m6A reader protein ECT2 is regulated upon HS, and its functional role on transcriptional regulation. Data and biological resources obtained by the team support the MemoryRNA project and incorporate a comprehensive set of cutting-edge technologies and approaches, including: i) Direct sequencing of long-read fragments and computational analysis for accurate mapping of RNA marks; ii) Antibody-based techniques and mutant plants to validate and characterise the function of m5C- and m6A-containing mRNAs; and iii) RNA and fluorescence in situ hybridization, and laser confocal microscopy to investigate the role of ECT2 during thermomemory. Understanding the mechanisms that coordinate transcriptional activity of HS-memory genes in response to environmental stressors is of utmost importance to modern agriculture, and throughout the the funding period, opportunities for translation of our results to biotechnological application will be monitored and explored.

Mots clés : epitranscriptomics, rna modification, m5c, m6a, thermomemory, heat stress, shoot apical meristem, stem cell regulators, arabidopsis, thermopriming

Participants :
- Leibniz-Gemeinschaft (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Potsdam (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet IceSTRUQ (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The Antarctic and Greenland ice sheets are fundamental to the Earth's climate system and the main contributors to sea-level rise. The overall ice-thickness distribution of an ice sheet is computed from sparse ice-thickness measurements using reconstruction methods. This data sparsity results in a marked uncertainty of the ice-thickness reconstructions, which is never taken into account in a mathematically rigorous manner. This implies large deviations between different ice-thickness reconstructions, delivering inconsistent estimates of sea-level rise rates. To remedy this, we propose formulating the ice-thickness reconstruction as a Bayesian inverse problem that combines data and mathematical models for ice-sheet dynamics. The solution of this inverse problem is a probability distribution for the ice-thickness, resulting in a rigorous quantification of uncertainty. However, conventional numerical methods either break down or become impractically slow when solving this problem. To circumvent this, we propose the design of a Monte-Carlo Markov-Chain (MCMC) method that combines ideas from multi-fidelity and the stochastic Newton MCMC methods. These are two sophisticated mathematical techniques that have achieved extraordinary reductions in computational time, allowing for previously unfeasible computations. We will apply our method to reconstruct the ice-thickness of the Antarctic Peninsula Ice sheet (APIS). This important Antarctic region has a complex geometry that has defied existing ice-thickness reconstruction methods. Our Bayesian inversion approach has the potential of reconciling dissimilar estimates of ice-discharge by quantifying confidence intervals via uncertainty. This highly interdisciplinary project will develop the applicant's mathematical and glaciological knowledge in an internationally-recognized research team. Research will be complemented with enriching activities such as Antarctic fieldwork (as training) and supervision of PhD students.

Mots clés : bayesian inverse problems, mcmc methods, ice discharge, sea level rise

Participants :
- Université polytechnique de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €