Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet BAME (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

BAME is a project in applied mathematics tackling problems in kinetic theory of gases. We will focus on the system of Boltzmann-like equations that describes gas mixtures composed of monatomic and polyatomic gases. Experience has shown that kinetic models accurately describe strong nonequilibrium processes in gas flows. However, most of the mathematical theory is limited to the oversimplified case of a single monatomic gas. Our aim is to contribute in filling this gap between study of more intrigant gases suitable for applications and the current state of the art in mathematical theory of kinetic equations. Objectives are to study regularizing effects of the Boltzmann operator, integrability, smoothness and strict positivity of solutions, with the ultimate goal of encoding large time behavior using entropy methods. The project will bring together the researcher with distinguished expertise in modelling and analysis of polyatomic gases and mixtures at the mesoscopic level and the host with ground-breaking work on entropy methods for macroscopic systems. The two levels of descriptions will be bridged formally through hydrodynamic limits at the secondment, leading to the redesign of entropy production program to the system of interest. The fellowship will enable the researcher to gain new analytical skills and greatly improve transferable skills through the reach training offer at the host University of Graz. Moreover, it will significantly extend her research network and facilitate participation in leading events in the field, leading to the capability to launch her own research group in the future and to enhance the career perspectives in academia.

Mots clés : kinetic theory, system of boltzmann like equations, polyatomic gases, multi component gas mixtures, entropy methods, integrability propagation, regularity propagation, hydrodynamic limits

Participants :
- Université du Minho (Portugal) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Graz (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199440.96 €
Projet REBYOUTH (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

RebYouth main objective is to explore an entirely new area of research by focusing on the largely overlooked histories of Women*, Queer, Black and People of Colour (W*-Q-BPoC) in rebellious, dissident youth movements and alternative music cultures from the late 1970s of late state socialism to the early 1990s in Poland. The focus is on cultural heritage, dissident/cultural practices, infrastructures of support and collisions with dominant social, cultural and political regimes. Objectives are the: 1) Mapping of W*-Q-BPoC dissidence history and cultural heritage with focus on music in the broader context of independent culture. 2) Exploring public and private archives. 3) Capturing and analyzing life time biographies and oral history accounts of W*-Q-BPoC actors. 4) Empowering W*-Q-BPoC through inclusion into contemporary historical discourses and memory practices. 5) Analysing intersectional dissidence and collisions of sensible orders and developing a concept of intersectional critique. 6) investigating infrastructures of support. 7) Mapping and analyzing international connections, transfer and migration. The main empirical research methods include research in private and public archives and qualitative interviews - with a series of life history interviews tracing selected biographies in changing socio-political contexts and during migration. The mapping of projects, people, crews, networks, events and artefacts will be an ongoing process resulting in visual maps. Based on a cross-cutting analysis of biographies, infrastructures of support, and social positioning situational maps will be created.

Mots clés : intersectionality gender alternative music culture social movements late state socialism lgbtq

Participants :
- Muzeum sztuki nowoczesnej w warszawie (Pologne) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université de Graz (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 249301.2 €
Projet Micro-Insulin (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Diabetes is a chronic metabolic syndrome with millions of people affected globally, caused by impaired glucose metabolism due to insufficient pancreatic insulin release or the development of insulin resistance. To control the glycaemic load in the diabetic patient, insulin needs to be administered by parenteral injection which causes patient compliance issues. Oral administration of insulin is the preferred route but there is no oral insulin on the market because of the hurdles it faces in the gastro-intestinal tract. Oral administration is the preferred route but until now there is no oral insulin in the market because of the hurdle (gastric pH and enzymatic degradation, low permeability) it faces in the gastrointestinal tract. Therefore, there is an unmet need for oral insulin development. To solve these problems, we will use microneedle technology for development of oral insulin delivery (Micro-Insulin). Oral administration of Micro-insulin will be investigated at the level of physicochemical characterization, preliminary safety assessment in in vitro and ex vivo models, and pharmacokinetics and efficacy in in vivo rodent models. High insulin intestinal absorption will be expected from the polymeric needle microcapsule via its piercing mechanism with controlled and localised release of insulin, which will be facilitated by a polymer matrix and the permeating-enhancing cationic cyclodextrin polymer. The objective of the project is aligned with the EU’s Horizon 2020 Programme focus area - Health, Demographic Change and Wellbeing and UN Sustainable Development Goal - Good Health and Well-Being. The Global Marie Curie Fellowship research will be conducted in partnership with the outgoing phase at a renowned institution from a third countries and incoming phase at EU country. The team is well equipped with skill and infrastructure required for the project. This will help bring advanced skills to EU countries and will have a significant impact on the fellow's career.

Mots clés : oral insulin delivery, peptide delivery, drug delivery, microparticle, pharmaceutics, management of diabetes, drug formulation, microneedle technology, oral absorption, particle engineering

Participants :
- University College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 302331.36 €
- Mass General Brigham (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet MOFBINDER (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Reducing CO2 emissions urgently requires the deployment of large-scale carbon capture technologies, many of which are being developed using innovative materials like porous metal-organic frameworks (MOFs). However, MOFs are typically synthesized as small crystals or powders, making them unsuitable for adsorption systems due to the high-pressure drops caused by fine particles. To address this issue, MOFs must be shaped into larger particles using polymer binders. While studies have explored MOF materials combined with binders, no clear guidelines exist, and the design process is often based on trial and error.  This project aims to develop a computational approach for designing MOF-binder composites with enhanced mechanical properties and controlled porosity. By utilizing parallel molecular simulations, we will predict the interface properties in a high-throughput manner. Machine learning techniques, drawing from both simulated and literature-mined data, will enable the development of a robust screening method. Additionally, our work will be integrated with the state-of-the-art Process-Informed design of tailor-made Sorbent Materials (PrISMa) platform, which connects material design, process optimization, techno-economics, and life-cycle assessment. This integration will allow for the evaluation and comparison of MOF formulations in terms of their greenhouse gas emissions throughout the lifecycle of the carbon capture plant, addressing one of the final steps in the deployment of carbon capture technologies.  To achieve these goals, the Researcher will receive training in high-throughput atomistic simulation workflows, materials informatics, and machine learning for material discovery, along with a holistic engineering approach through PrISMa. Moreover, this project offers the Researcher the opportunity to apply her expertise to the field of composite design, bridging fundamental science with industry-oriented perspectives actively pursued at IMDEA Materials Institute

Mots clés : metal organic frameworks, material informatics, machine learning, carbon capture

Participants :
- Epfl (Suisse) — Partner, associated partner, Recherche, subvention : 0.0 €
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €
- Université Heriot-Watt (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet 400K Memories (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Following the eruption of a major social crisis in an “Outermost region of European Union” (ORs), French Guiana, which gave rise to the “French Guiana political agreement” in 2017, the French government committed to a full retrocession process of 400,000 hectares of land to Indigenous communities (Native Americans). 400,000 ha of land, it’s also 400,000 different memories of the land, and certainly even more. This project aims to strengthen and make visible Indigenous representations in the overall institutional process of land retrocession. This participatory project implements the creation of an original and unpublished double corpus, previously unseen in French Guiana. By associating an artistic and a narrative approach, “sensibility mapping” allows for the visualisation of the intimate aspects of Indigenous stories. Over the last decade its potential to integrate qualitative data such as emotions and sensations into maps has caught the attention of a few geographers. Our first goal is to develop a first series of “sensibility maps” with Indigenous storytellers through an innovative mapping process designed to put the stories about the land memory into full light (O1). Our second goal is to represent the creative process at work when drawing the first series of maps, using the very same sensibility mapping method and drawing a second series of maps (O2). Our last and most ambitious goal is to create a hybrid open-data archive designed to foster a new use of the research material through a cross-mapping innovation between geolocated and sensibility maps (O3). The recent research in history of cartography has highlighted the importance of documenting the mapping process itself. But as of today no visualisation technique has been developed to represent that process. From a methodological perspective this project is thus timely, as it is from a cultural perspective since it will engage a mapping experiment at a crucial political moment in French Guiana history.

Mots clés : autochthony, french guiana, outermost region of eu, land retrocession process, collaborative cartography, mapping innovation, life stories, cultural memory, sensibility mapping, social transformation

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet PiES-on-chip (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Separating the two enantiomeric versions of a chiral molecule is crucial for ensuring the safety of pharmacological drugs and agrochemicals for the human body and the environment. However, the enantiomeric separation process at industrial level through chiral chromatography is costly and slow. As a result, 90% of chiral pharmaceutical drugs and agrochemicals are being sold as racemic mixtures.  The PiEs-on-chip project aims at exploiting enantio-selective optical forces produced in silicon-based Photonic Integrated Circuits (PICs) to separate enantiomers. The chiral light-matter interaction, between the light guided throughout the PIC and the enantiomers results in a momentum transfer due to optical forces that move the particles of opposite chirality in opposite directions, leading to their Photo-induced Enantiomeric Separation (PiES). The PIC would be easy to mass-produce at low cost per device, thus, making optical enantiomeric separation more viable at industry level. Guided modes along integrated rectangular waveguides demonstrated inherent transversal and/or longitudinal spin which generates chiral optical forces that could be used for separating chiral particles in the transversal and/or longitudinal direction. Although the use of silicon-based waveguides is promising, they still lack more strength in the optical forces that can exert on smaller particles like molecules, partially due to the simple designs of the tested PICs. This requires new strategies to enhance enantio-selective interactions.  The PiES-on-chip novel approach consists in inversely designing the PIC with topology optimization with the objective of maximizing the produced enantio-selective optical forces. Next, we will fabricate the optimized PIC and measure the generated chiral optical forces with Photo-induced Force Microscopy. Finally, we will deliver the chiral particles over the PIC with a microfluidic layer and experimentally verify the laser-driven enantiomeric-separation on chip.

Mots clés : chiral optical forces, nanophotonics inverse design, force microscopy, microfluidics, enantiomeric separation

Participants :
- Université polytechnique de Valence (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet URBANE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

URBANE addresses an important and timely question: how does the urban environment impact the developmental origins of multimorbidity? Neurodevelopmental, cardiometabolic and respiratory adverse health outcomes are increasingly prevalent at young ages, with diseases such as obesity and asthma affecting up to four out of ten children in Europe. Multimorbidity, the co-occurrence of two or more health conditions, in childhood is thus becoming a major public health problem with short- and long-term consequences. Although it is well known that environmental hazards play a role in the development of diseases, the contribution of the complex environment in which we grow up and live on the development of multimorbidity remains unclear. URBANE addresses this knowledge gap. The project will leverage the resources of the Portuguese population-based birth cohort Generation XXI and follow an exposome-wide approach to the study of urban environmental impact on childhood multimorbidity. For that, the project will use a wide range of geospatial urban exposure data (e.g., air pollution, and characteristics of the urban natural and built environment) and multiple adverse health outcomes (e.g., high blood pressure, obesity, asthma, behavioral problems) collected at the vulnerable early stages of the lifecourse (pregnancy and childhood). The project will explore socioeconomic status and gender differences and also assess whether DNA methylation changes and dysregulation of hormone leptin explain the urban environmental impact on multimorbidity. URBANE will contribute to the discovery of urban environmental priorities, vulnerable subpopulations and aid in the identification of underlying mechanisms. URBANE is highly interdisciplinary, and fosters knowledge exchange. The project aligns with major EU strategies related to the urban environment and non-communicable diseases prevention, and thus its results are expected to be of high relevance for researchers, policy makers, and society.

Mots clés : exposome early life origins children multimorbidity

Participants :
- Université de Bristol (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut de Recherche et d’Innovation en Santé de l’Université de Porto (Portugal) — Coordinator, beneficiary, Recherche, subvention : 182245.2 €
Projet ZEPHYRUS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Horses provided humans with the ability to travel well above their own speed and changed the way they made war. As such, the domestication of the horse ~5,500 years ago, represents a historical turning point in human history. Throughout the whole Upper Palaeolithic period and right into the Holocene, Iberia has always offered favorable climatic conditions for equine populations to thrive. Much remains to be discovered on the horses that once roamed the region. For instance, the true nature and diversity of the Iberian horse represented in the famous cave paintings of Altamira remains unknown. The exact dynamics underlying their replacement by foreign domestic horses during the Bronze Age is also debated. Similarly, while the Muslim expansion of the C7th-C9th is known to have reshaped the genetic makeup of horses across Europe, the exact impact of this expansion in Iberia is unknown, despite Muslim kingdoms being maintained there up until the C15th. The same holds true for previous equine civilizations such as the Phoenicians who traded in the area, or the Romans who largelly expanded into the region. Finally, the true extinction timing of the Iberian zebro, an European wild ass closely related to Asian hemiones, is contentious, with some scholars advocating survival up until the Middle Ages. By focusing on a single region, Iberia, the ZEPHYRUS project provides the unique opportunity to solve many long-standing debates in horse evolution and (pre-)history. Through the development of innovative genotyping solutions and state-of-the-art approaches in ancient DNA research, ZEPHYRUS will genetically predict how the physical traits of Iberian horses have changed since the Upper Palaeolithic and how different equine civilizations have remodelled the Iberian horse through space and time. Reciprocally, ZEPHYRUS will unveil the influence that Iberian horses have had an how they contributed to reshaping the genetic makeup of other European regions.

Mots clés : ancient dna, animal domestication, genomics, iberian peninsula, horse, mule, zebro, high throughput dna sequencing

Participants :
- Université de Toulouse (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 210984.88 €
Projet GlutaMature (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

All aspects of brain function rely on the interplay between networks of functionally related neuronal cells. These cells are connected by “synapses”, which are specialized cellular compartments dedicated to rapid electrical and chemical signalling. Excitatory neurotransmission in the vertebrate central nervous system (CNS) is largely mediated by the ionotropic glutamate receptors (iGluRs). These postsynaptic receptors conduct cations into the cell in response to binding of the neurotransmitter glutamate released from presynaptic vesicles. Accumulation and positioning of iGluRs at neuronal synapses are crucial for enabling correct neurotransmission. While it is known that extracellular scaffolding proteins (ESPs) interact with iGluRs to stabilize these receptors at synapses, the transient, low-affinity nature of these protein interactions has so far precluded complex structure determination and therefore a precise mechanistic understanding of their function. The aim of this proposal is to implement state-of-the-art techniques of protein engineering to stabilise iGluR:ESP interactions for structure determination by affinity maturation of their interaction interfaces. I will focus on two well-established complexes: Cerebellin-Glutamate receptor Delta (Cbln-GluD) and Neuronal Pentraxin-AMPA receptor (NP-AMPAR). Structural insights into the full-length synapse-spanning Cbln-GluD and NP-AMPAR interactions will elucidate how clustering and trans-synaptic anchoring of iGluRs contribute to synaptic transmission, as well as pave the way for the design of engineered synaptic organizer proteins capable of remodelling synapses. During this project I will gain experience in protein engineering which will allow me to establish a career as an independent scientist with a focus on tackling complex structural biology problems with translational applications.

Mots clés : integrated structural biology, protein engineering, transsynaptic assembly, x ray crystallography, electron microscopy

Participants :
- Université de Bordeaux (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €