Projet FunHoMic (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Fungal infections have a major impact on human health, infecting about 2 billion people and killing more people each year than malaria or breast cancer. In particular, Candida species impose a high clinical and economic burden upon the European population. They frequently cause fatal hospital-acquired bloodstream infections. They also cause oral thrush and vaginitis. Most women have suffered an episode of vulvovaginal candidiasis, with ~8% enduring recurrent infections. The initiation and severity of a Candida infection depends on an intricate interplay between the infecting fungal strain and the individual’s immune status and microbiota, all of which can display significant variability. Therefore, for the first time, FunHoMic integrates experts in fungal pathogenesis, immunology, microbial ecology and ‘omics technologies to train 13 Early Stage Researchers (ESRs) who will define and exploit this Fungal-Host-Microbiota interplay to identify novel biomarkers (fungal or host genetic polymorphisms, microbiota profiles, metabolites or immune markers) for the stratification of a patient’s risk of serious fungal infection. This will pave the way for precision medicine in patient management through preventive or therapeutic interventions using antifungals, immune modulators or Live Biotherapeutic Products (LBPs). FunHoMic ESRs will gain broad interdisciplinary skills plus a translational mindset through our integrated, inter-sectoral training program. This will allow Europe to remain at the forefront of translational research in the field of medical mycology. To achieve this vision FunHoMic unites academic partners from France, Germany, The Netherlands, Switzerland, Spain and UK, a French Technology Research Institute with cutting-edge ‘omics technology platforms and three SMEs from The Netherlands, Belgium and France that bring unrivalled organ-on-chip and gastro-intestinal tract simulation technologies and expertise in the development and exploitation of innovative LBPs.

Mots clés : molecular medical mycology, candida, microbiota, omics technologies, immunology, fungal infections, ex vivo infection models, animal models

Participants :
- University of Zurich (Suisse) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281276.64 €
- Mag- microbiota anima group (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 79921.59 €
- Institut Pasteur (France) — Coordinator, beneficiary, Recherche, subvention : 549604.08 €
- Radboud University Nijmegen Medical Centre (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110674.95 €
- CERCA Institution (Espagne) — Partner, beneficiary, Recherche, subvention : 250904.88 €
- Ghent University (Belgique) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Nexbiome therapeutics (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 194880.45 €
- BIOASTER (France) — Partner, beneficiary, Recherche, subvention : 274802.04 €
- Friedrich Schiller University Jena (Allemagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Clermont Auvergne (France) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Radboud University Nijmegen (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 154944.93 €
- Evotec (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Autonomous University of Barcelona (Espagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Leiden University (Pays-Bas) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Aberdeen (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- Leibniz Association (Allemagne) — Partner, beneficiary, Recherche, subvention : 505576.8 €
- ProDigest (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 256320.0 €
- Université Paris Cité (France) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Mimetas (Netherlands) (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 265619.88 €