Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet BRAINSTOM (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Hunger, satiety and feeding are complex phenomena exerting a profound influence on health and wellbeing. Hunger, or the mental urge to eat, is often associated with the feeling of an empty stomach. Satiety refers to a cascade of physiological, neural and metabolic mechanisms that inhibit further eating. Importantly, the decision making process in the brain that determines what, when and how much we eat is modulated by subconscious signals from the gut that can activate the brain’s dopaminergic system and reinforce dietary habits, explaining why so many people struggle to make healthy food choices and why the prevalence of obesity in developed countries is so high. Scientific knowledge on the brain-gut mechanisms behind hunger and satiety is incomplete, limiting our ability to develop efficient therapies and public policies targeting obesity and overweight. In BRAINSTOM, I have designed an innovative research program to study how the brain’s signatures of hunger and satiety are linked to the movements and contractions of the stomach, combining my previous expertise in the simultaneous recording of the stomach and functional magnetic resonance imaging in humans with research methods from nutrition and metabolism and recent advances in positron emission tomography of the dopaminergic system. The three key hypotheses of my research proposal are that i) hunger feelings are associated with measurable changes in movements and contractions of the stomach ii) as food transits through the stomach, the brain releases dopamine and satiety feelings arise iii) the electrical activity of the stomach interacts with cortical, subcortical and neuromodulatory brain structures, influencing brain activity, interoception and cognitive functions beyond feeding. These findings will inform novel theories of brain-body interactions and will lead to the development of novel psychological and pharmacological interventions to reduce obesity and overweight.

Mots clés : brain, stomach, satiety, hunger, dopamine, resting state

Participants :
- Leibniz Association (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 162806.4 €
Projet DISMOD-HD (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Huntington’s disease (HD) is a rare and devastating autosomal dominantly inherited disorder caused by the amplification of the CAG codon in the huntingtin gene. The clinical symptoms of HD are chorea and motor incoordination as well as psychiatric symptoms. To date no cure has been found to alter the progression of the striatal atrophy due to the dramatic loss of GABAergic medium spiny neurons (MSNs) which eventually leads to death. Over the past years increasing knowledge around the function of huntingtin (HTT) has allowed the identification of number pathogenic mechanisms, however the specific processes whereby the mutated HTT leads to degeneration and their temporal evolution remains unknown. We believe it is of vital importance to develop disease-relevant human cell models from clinically characterized HD subjects in which to address questions related to pathogenic mechanisms and their dependence on the CAG repeats. For this reason the aim of the proposed project is to generate induced medium spiny neurons (iMSNs) from healthy or HD-diseased fibroblasts in order to generate a reliable disease modelling tool. The applicant will optimize an existing protocol for the generation of iMSNs from direct conversion of fibroblasts published by Victor et al (2014) to obtain healthy iMSNs in the laboratory of prof. Elena Cattaneo at the University of Milan. In a second step she will perform direct in vitro reprogramming of human fibroblasts derived from well characterized patients affected with HD exhibiting different degrees of CAG repeat expansion into induced HD-derived MSNs (HD-iMSNs). Finally, the newly generated HD-iMSNs will be analyzed, and their characteristics compared to those of the healthy iMSNs, in order to assess their appropriatness as a disease modelling tool to investigate the pathophysiology and pathogenesis of HD.

Mots clés : direct reprogramming, medium spiny neurons, huntington disease, disease modelling

Participants :
- University of Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet CarbonChem (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) are two key half-reactions in electrochemical water splitting, which is an eco-friendly technology to produce hydrogen. Both of the half-reactions are limited by high overpotentials and interaction between the reactions. Until now, electrochemical water splitting still relies on some inorganic noble-metal catalysts. Exploiting highly-efficient low-cost bifunctional electrocatalysts is a promising method to solve these issues. Thus, CarbonChem project aims at overcoming the limitation of traditional inorganic materials and re-defining the designing concept to construct organic framework electrocatalyst for HER and OER. Owing to the high designability and porous structure, organic frameworks are considered as a reasonable alternative to construct electrocatalysts; but the low conductivity strictly restricts their utilization. Incorporation sp-hybridization of graphdiyne (GDY) into organic frameworks can overcome the bottleneck, which provides the possibility for achieving organic electrocatalysts. As a result of single chemical composition, the active centres of GDY are consisted of unsaturated C and N sites, which are hard to provide high catalytic activities for HER and OER. Focusing on this issue, this project will give new insights on GDYs, providing a design concept for their chemical structure. Employing conjugated porphyrin with four coordinated N sites is a new strategy for introducing metal atoms into GDYs. Constructed metalloporphyrin-based graphdiyne (MPGDY) is fully consistent with the design principle of electrocatalyst: high conductivity, effective active sites and mesoporous structure. This research will develop an efficient bifunctional MPGDY electrocatalyst, for European hydrogen industry. The ER will achieve abundant research experience and scientific skills from the CarbonChem project and the capability to launch his own research group in future.

Mots clés : porphyrin, graphdiyne, bifunctional

Participants :
- University of South-Eastern Norway (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €
Projet ModCat4OER (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Hydrogen is considered essential to reach the European Green Deal and Europe´s clean energy transition. Nowadays, most hydrogen is produced by reforming of fossil fuels. Electrochemical water electrolysis using renewable sources as energy input represents a cleaner way than reforming of fuels to create hydrogen. However, water electrolysis will only be feasible if stable, affordable and effective catalysts for oxygen evolution reaction (OER) are discovered. The research objective of this project is to explore the catalytic activity in OER of Earth abundant transition metal oxides to gain fundamental understanding on the nature of the active sites. To this effect, ordered thin films will be grown, aiming to discover the most active formulations and facets of the crystal structure. This project will be performed at the Fritz-Haber-Institut der Max-Planck-Gesellschaft (MPG), in the department of Interface Science lead by Prof. Roldán Cuenya. MPG was ranked as the third top institution according to the Nature Index 2019. I will work with Dr. Kuhlenbeck, an expert in the surface science field. Merging of his experience in growing thin films with the my background in electrochemical processes is key for the success of the project. During the two years of the project, I will be involved in the dissemination of the results to Academia and the general public through participation in conferences, publication of articles and outreach activities. An individual Career Development Plan, outlined and reviewed by Dr. Kuhlenbeck and Prof. Roldán Cuenya, will be used to monitor the research maturity obtained during the project.

Mots clés : oxygen evolution reaction, electrochemistry, electrocatalysis, active sites, magnetism, hydrogen production

Participants :
- Max Planck Society (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 162806.4 €
Projet SmartGas (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Statut du projet : CLOSED

I am proposing a novel acoustic MEMS gas sensor with machine learning for the first time that can revolutionize the gas sensing field. Gas sensors targeting only a specific type of gas are developed due to the nature of the existing sensing technologies. Current gas sensors either rely on the detection of the electrical property changes upon the reaction of an active material with the gas or infrared (IR) transmission/absorption characteristics of the gases. I am proposing to couple the acoustic resonance in a cavity with a MEMS resonator and use the coupled resonance and damping as a gas sensor. Acoustic frequency and the damping are a function of the gas inside the cavity, and together can be used to detect any gas with machine learning. Since the frequency and damping change with multiple gases in the proposed approach, machine learning algorithms can extract the gas changes in a smart way. Proposed sensor solves the problems of the current gas sensors. It can be manufactured with standard MEMS fabrication flows, can be used with any gas, does not saturate, and has immediate response time. The sensors will be fabricated in the fully equipped clean room UNAM in Bilkent University. I will apply the sensor on human health by working with a pulmonologist to measure CO in human breath and indoor air quality. My supervisor Prof. Hilmi Volkan Demir will guide me throughout the project and help me to improve my technical and soft skills. I will also be able to improve my network and knowledge during my secondment in Fraunhofer EMFT, Germany. Collaborating with Analog Devices and Fraunhofer will be the key for further product technology development. In summary, this fellowship will establish me as a recognized European leader by demonstrating a proof of concept with interdisciplinary research (MEMS, machine learning, and medical application), by patenting and publishing my innovation, and by enabling the path for low cost universal gas sensor productization.

Mots clés : mems, gas sensing, acoustic resonance

Participants :
- Bilkent University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 157355.52 €
Projet NOJUNKDNA (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

I here propose a strategy to investigate cell type-specific effects of non-coding regulatory elements, which have been shown to play a fundamental role during the molecular pathophysiology of complex neurodegenerative diseases such as glaucoma in the eye or Alzheimer's or Parkinson's in the brain. By leveraging techniques from various scientific disciplines such as synthetic biology, next-generation-sequencing and bioinformatics, a system will be designed that is capable of quantifying thousands of regulatory elements such as enhancers, promoters or insulators, in a single experiment and for a specific cell type of interest. The overall goal is to demonstrate feasibility for creating an approach that can be used to study the effects of non-coding loci in neurodegenerative diseases, and to evaluate the contribution of genetic background to regulatory element use.

Mots clés : non coding genome, regulatory elements, neurodegeneration, systems genetics, next generation sequencing, massively parallel reporter assay, cell type specificity

Participants :
- Ludwig-Maximilians-Universität München (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171460.8 €
Projet SHOALS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

I propose to carry out the Swift Gamma-Ray Burst Host Galaxy Legacy Survey (SHOALS), a multi-national, multi-facility, multi-wavelength eﬀort to characterize the gamma-ray burst host galaxy population and how it connects to other star-forming galaxy populations at high redshift. Gamma-ray bursts represent invaluable tracers of the conditions in distant galaxies and provide a unique means of measuring the contribution of the faintest and highest-redshift galaxies to stellar mass assembly, yet we still do not understand what their progenitor system is or what environmental inﬂuences cause GRBs to explode more frequently in certain types of galaxies than others. By intensively charactering a large population of uniformly-selected GRB hosts across cosmic history, I will disentangle the various factors that may inﬂuence GRB production (chemical composition, starburst intensity, population age) and apply these results to better understanding how these violent explosions are produced and how we can use them to better understand the earliest phases of galaxy evolution.

Mots clés : star formation, gamma ray bursts, galaxies, early universe

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200194.8 €
Projet MagTopCSL (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : TERMINATED

I will explore superlattices and heterostructures in chalcogenide materials as a platform for Berry-curvature engineering and topological devices. To this end, I will study superlattices created by superimposing single- and bilayers of transition-metal dichalcogenides with periodic arrays of magnetic adatoms in various configurations. Moreover, I will study multilayer heterostructures of group-II monochalcogenides with a compositional gradient across layers. The interplay of the underlying electronic structures with the ingredients and configurations of the superstructures is envisioned to lead to new phases with highly altered properties. I will study this interplay theoretically with a focus on three main objectives: (i) designing quantum anomalous Hall phases with large Chern numbers, which is highly relevant for electronic devices with low-power consumption; (ii) realizing topological superconductors as a platform for Majorana quasiparticles, which hold potential for exotic nonlocal phenomena and quantum computers; and (iii) realizing stable intertwined order in a 3D material with flat energy bands, a research direction I will pioneer with this project. I will model the proposed setups numerically using low-energy tight-binding models of the materials. The models will be constructed in close collaboration with experimentalists and DFT experts at the host institution MagTop within IF PAN. I will calculate Berry curvature, topological invariants, magnetic order, phase diagrams, and signatures of the emerging phases with regard to charge, spin, and thermal transport. The code used for the calculation of these quantities will be implemented as a software package, which I will utilize and develop during this project. My investigations will provide concrete guidelines for accompanying experimental studies at MagTop. In this way, the outcomes of my project will lay the foundation for tunable topological devices based on chalcogenide superlattices and heterostructures.

Mots clés : berry curvature, chern number, topological insulator, topological superconductor, chalcogenides, superlattice, multilayer, moir  superlattice, magnetic impurities, flat bands, intertwined order

Participants :
- Polish Academy of Sciences (Pologne) — Coordinator, beneficiary, Recherche, subvention : 137625.6 €
Projet Origen on the Psalms (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

I wish to conduct an in-depth study of Origen’s (d. 254) Homilies on the Psalms, a collection of 29 Greek exegetical homilies on ten biblical psalms. The discovery of this text in 2012 is one of the most important in the history of scholarship on early Christianity, given both Origen’s influence on the subsequent early Christian exegetical tradition and the importance of the Psalms for the early Church. Study of these homilies has only just begun; the critical edition was published in 2015, and the English translation is still underway. I propose a project in three stages in order to make an important contribution to this early phase of research. In the first stage I will conduct a close textual analysis of the homilies. I will analyze Origen's grammatical and rhetorical argumentation, in addition to his philosophical, theological, and moral explanations of the psalms. In stage two I will primarily employ the modern literary theory of tradition history, in order to examine the traditions that influenced Origen in his exegesis of the psalms, such as his use of the exegesis of Philo, Clement, and the New Testament author, Paul. In the third stage I will analyze comparatively Origen's Homilies on the Psalms and his Homilies on Jeremiah, his only other extant Greek homilies prior to the 2012 discovery. This comparison will shed light on the extent to which his treatment of the Psalms is distinctive within his exegetical writings. I am well suited for this task, as I have already worked on early Christian exegetical techniques and with much of Origen’s corpus in my doctoral research. I have already begun preliminary research on the Psalm homilies. The School of Culture and Society at Aarhus University is the ideal place to conduct this study as Anders-Christian Jacobsen, my proposed supervisor, is a world-renown Origen scholar. In addition, many of the school’s researchers are experts in early Christian scriptural interpretation and the methods of tradition history.

Mots clés : origen of alexandria, early christian scriptural interpretation, early church history

Participants :
- Aarhus University (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet ICFOstepstone (Horizon 2020, appel à projets 2015)
Action : Cofund Doctoral programme
Statut du projet : CLOSED

ICFOstepstone is being proposed as an evolution of the current PhD-programme, offering competitive fellowships, paired with dedicated training actions within the chosen research field as well as for acquiring transferable skills, implementing mobility-actions in form of compulsory secondments at partner institutions in academia and industry alike, aiming at an integrated PhD aligned with the objectives in H2020. We aim at promoting an international research environment where traditional boundaries between fields and sectors are crossed and multidisciplinary projects undertaken, therefore aiming at covering the triple “i” dimension. It is expected that the award of a Fellowship under the proposed Programme will significantly boost the Fellow’s career perspectives and their connections, enabling a diverse career path in the most important institutions worldwide of their chosen sector, therefore guaranteeing a smooth and successful transition to their next career step. The ICFOstepstone is considered to be a natural advancement from the COFUND programmes ICFO launched in the past, in terms of now expanding our efforts to the postgraduate level, to establish a long-term talent pipeline at any career level. This COFUND action therefore proposes a change in the focus group of potential recipients from the Experienced Researchers to Early Stage Researchers. Also, with ICFOstepstone, the excellence approach not only aims at an enhancement of the Recruiting & Hiring Life-Cycle but also at an enhancement of the Career Development Plan. As shown in the proposal, ICFO has the necessary expertise to implement and develop the programme due to its broad and proven track record in the management of international research and education programmes. The proposal is also in line with current strategical ICFO HR and Education Objectives: working towards the implementation of the “HR Strategy for Researchers” and towards further strengthening and enlarging our training programme.

Mots clés : physics, biophotonics, quantumphotonics, nonlinear photonics, nanophotonics, mobility, training, transferable skills, secondments, early researchers, international, intersectoral, interdisciplinary

Participants :
- Institute of Photonic Sciences (Espagne) — Coordinator, beneficiary, Recherche, subvention : 1962000.0 €
Projet ELITE-S (Horizon 2020, appel à projets 2017)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

ICT standards play an essential role in achieving interoperability of new technologies and can bring significant benefits to both industry and consumers. They support the realisation of a European Digital Single Market and allow consumers and businesses the widest choice of products and services across the EU. DCU, host to the ADAPT Centre, is an international hub of scientific expertise related to ICT standards in areas such as data and regulation technologies, data privacy and protection, content analytics, machine learning, preservation, personalisation and interoperability, data and process management. ADAPT will host the ELITE-S Programme which will offer 16 prestigious two-year fellowships for incoming mobility across three calls over the 72 months duration of the programme. Fellowships will be offered in the four core research areas Regulations and Compliance, Content Analytics and Content Preservation, Data and Process Management, Interoperability. ELITE-S applicants will have the freedom to choose their own research topic, their supervisor and their secondment host. The ELITE-S programme will offer excellent quality in the selection of researchers, and high quality training, supervision and training in transferable skills. Specifically: -Provide a state of the art research environment in the area of ICT standardisation related to the programme's core research areas that will stimulate and challenge researchers while developing them as research leaders of the future -Provide fellows with industry-specific training and secondments in priorities sectors including 5G, Internet of Things, Cloud computing, cybersecurity and data technologies -Implement a transparent evaluation and selection process for recruitment -Provide an attractive and supportive working environment for fellows where they are truly integrated into ADAPT and their academic host The ELITE-S programme will train the next generation of leaders in ICT Standards.

Mots clés : standardisation, fintech, compliance, interoperability, data management, health informatics, regtech

Participants :
- Dublin City University (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1132800.0 €