Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HER-AWARD (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The Amazon River Basin is under threat due to climate change, deforestation, and forest fire. Hydroclimatic records show an increase in both the duration and intensity of droughts with remarkable events occurring in the past 20 years in the region. Climate projections indicate overall drier conditions for most of the Amazon in the next decades, together with a higher frequency of extremes such as droughts and floods. By means of positive feedback between climate change and deforestation, changes in precipitation, evapotranspiration, and air temperature exacerbate extreme droughts, which frequently co-occurs with heatwaves and forest fires, the three of them being referred to as dry hazards. Compound dry hazards pose health impacts that can be felt differently according to gender, with increasing evidence suggesting that women suffer more intensively because of social norms regarding gender roles as well as due to physiological factors related to reproductive health. HER-AWARD (Health Risks to Amazon Women and Adaptation of Riverine Communities to Dry Hazards) is an interdisciplinary research project aimed to elucidate the intersectional dimensions of health risks associated with dry hazards among women from riverine communities of the BR Amazon. The project seeks to understand the overlapping impacts of compound dry hazards and their cascading effects on women's health. The research is organized into primary components that explore two different spatial scales: starting from a basin-wide perspective and zooming in to a community level. By integrating these scopes, HER-AWARD aims to generate actionable insights and inform effective interventions tailored to the unique needs of riverine women in the Amazon, grounded on scientific and local knowledge through a gender lens. The project is based on an interdisciplinary methodology, combining large-scale environmental modelling, hydrological and spatial analysis, as well as case study social science methods.

Mots clés : climate change drought tropical forest river basin freshwater traditional communities indigenous and local knowledge navigation hydrology heatwaves fire deforestation

Participants :
- Woodwell climate research center, inc (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université Humboldt de Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202125.12 €
- Université autonome de Barcelone (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MALBENA (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cardiovascular disease is a leading cause of morbidity and mortality in Europe and, in the face of population aging, this statistic is predicted to significantly worsen. One of the major CVD risk factors is represented by the alterations of beta-adrenergic receptors stimulation, which modulates the function of the voltage-gated sodium channel, Nav1.5, in cardiomyocytes. In a healthy heart, beta-adrenergic receptors regulate the function of Nav1.5 to potentiate cardiac contraction during common everyday activities like physical exercise. However, the same pathway promotes and worsens cardiovascular disease such as heart failure. Thus, there is an urgent need to investigate how a healthy physiological response becomes deleterious in order to better understand cardiovascular disease occurrence and hence to improve its treatment. MALBENA will address this challenge through an ambitious and interdisciplinary study that will thoroughly assess molecular and functional modifications of Nav1.5 in the beta-adrenergic receptor-stimulated cardiomyocytes as well as in human failing and non-failing hearts. Such profiling of the physiological and pathological remodeling of Nav1.5 will provide a substantial impact on the novel strategies developing targeted therapies aiming to reduce the cardiovascular disease burden and, at the same time, having little to no side effects on the other organs, since Nav1.5 is nearly exclusive to cardiomyocytes. The combination of unique expertises of the host supervisor, Dr. Céline Marionneau, in phosphoproteomics of Nav1.5, and of the researcher, Dr. Oksana Iamshanova, in Nav1.5 functioning as the macromolecular complex, will enable synergistic implementation of the scientific backgrounds, techniques, and methods to guarantee the successful achievement of MALBENA’s objectives.

Mots clés : heart, cardiomyocyte, channelopathy, voltage gated sodium channel, beta adrenergic stimulation, phosphorylation, interactome

Participants :
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 242260.56 €
Projet TNT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Tauopathies, including Alzheimer’s Disease (AD), characterized by the brain accumulation of abnormal Tau proteins, represent a significant unmet medical need. Neuroinflammation is a hallmark of these diseases. Although several neuroimmune regulations, notably involving microglia, have been largely studied recently, the role of neutrophils and the release of neutrophil extracellular traps (NETs) has been overlooked. The TNT project will fill the gap as aimed to (1) characterize the temporal dynamics of neutrophil and NETs involvement vs. Tauopathy progression and (2) evaluate the functional impact of NETs and type I interferon (IFN-I) on disease pathogenesis. Using a combination of approaches, including Tauopathy and Tau seeding models together with post-mortem tissue of patients with primary Tauopathy, the TNT project will advance our understanding of the complex interplay between NETs, glial and Tau pathology, potentially leading to novel therapeutic strategies. The project will study the influence of the biological sex on these mechanisms and assess their therapeutic potential.  The host institute provides a robust platform for bidirectional knowledge exchange, with expertise in Tau transgenic and seeding models, 3D glial cell reconstitution, and inflammasome-Tau pathology, significantly enhancing our research on glial cell changes. My expertise in neuroimmunology and neutrophil biology, will be instrumental in advancing ongoing projects at the host lab. The planned training will enhance my research skills while fostering independence, mentorship, and communication abilities, preparing me for leadership. Engaging in mentorship activities and workshops will equip me with skills to guide and inspire junior researchers, and enhance my ability to communicate complex concepts to diverse audiences. This development will position me as a young leader in neurodegenerative diseases, ready to make significant contributions to scientific advancement and knowledge transfer.

Mots clés : tauopathies, microglia, type i interferon ifn i , neuroimmune, neuroinflammation

Participants :
- Université de Lille (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 242260.56 €
- Institut national de la santé et de la recherche médicale (France) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet Circanycyte (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The suprachiasmatic nucleus (SCN) of the brain, our internal clock, synchronizes physiology to the Earth’s rotation using signals from the environment such as light and food intake. However, in industrialized cities, these same signals at wrong times uncouple the internal clock from the environment, leading to circadian misalignment, such as in night and shift workers, who have elevated risks of developing obesity and metabolic syndrome. Nevertheless, effective measures to delay or limit health costs for these people are yet to come. Recently, I described novel vasopressinergic SCN neuronal (SCNAVP) fibers in the vicinity of non-neuronal hypothalamic cells known as tanycytes that have the ability to sense and transport metabolic cues. Whether the sensor and transporter functions of tanycytes are regulated in a circadian manner by the SCN, and whether this regulation plays a role in the development of metabolic impairments during circadian misalignment, are unknown. Thus, in the Circanycyte project, we will seek to 1) determine how SCNAVP neurons control tanycytic function, 2) explore the role of SCNAVP neuron-tanycyte communication in circadian alignment and metabolic fitness, and 3) determine the contribution of SCNAVP neuron-tanycyte miscommunication to the development of metabolic syndrome during circadian misalignment. To accomplish these aims, I will undergo training in cutting-edge technologies (e.g. Ca2+ in vivo imaging of tanycytes, with simultaneous optogenetic manipulations), while I exercise my leadership and management skills by working in a top laboratory, using the experience as a launching pad for international collaborations in frontier science in the EU. My original angle of research, hypothesizing that tanycytes, which extend processes outside the blood-brain barrier, are key targets of the SCN to regulate metabolism, is a strategic choice that promises to uncover new actionable pharmaceutical targets to fight desynchronization-related disorders

Mots clés : circadian rhythms, tanycytes, neuron glia interactions, circadian misalignment, metabolic syndrome, obesity, suprachiasmatic nucleus, medio basal hypothalamus

Participants :
- Université de Lille (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
- Institut national de la santé et de la recherche médicale (France) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet GREENLAM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : TERMINATED

Engineering novel materials and their design optimization using simulation-based tools enable the development of lightweight and sturdy thrusters. In Europe, the development of high-temperature-resistant structural materials for space transportation has gained momentum over the years. This has led to the increased usage of ceramic matrix composite over conventional metal alloys in aerospace applications. Most of the reported works focus on manufacturing cost-effective and lightweight composites, whereas the thermally stable nature of composites has not been fully explored. The Green Charter and European Green Deal promote low-emission forms of transport and emphasize developing sustainable and renewable forms of energy. The adoption of green fuels offers advantages in terms of total life cycle cost reduction, contributing to cheaper space transportation, and environmental impact reduction. Contemporary research innovations have expanded the development of "green propellants" for spacecraft in diverse space applications on a global level, primarily for eco-innovation and safety considerations. Studies with ammonium dinitramide, hydrazinium nitroformate with methanol, and ethanol-water are still in the nascent phase whereas H2O2 is delivering state-of-the-art performance to replace conventional hydrazine. This project aims to explore the possibility of developing a 1-100N class thruster made of thermally stable composite (carbon-ceramic) and green bipropellant (H2O2-Kerosene) system for the upper stage to reduce the overall weight, life cycle cost, and environmental impacts without compromising on the performance parameters. This will be researched through a comprehensive blend of multi-physics-based numerical modeling and analysis to generate a highly reliable design and a scale-specific experimental characterization and test rig to yield propellant formulation data corresponding to the state-of-the-art. The proposal will produce high societal, scientific, and economic impacts.

Mots clés : nanofiber green propellant h2o2 high test peroxide composites eco innovation sustainable design

Participants :
- Université de technologie de Delft (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 254330.4 €
- Solvge b.v. (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet LightHeal (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Self healing polymers, i.e., materials which the ability to repair themselves, have emerged as an attractive alternative to traditional materials due to the advantages they offer to society in terms of durability, reliability and cost and energy efficiencies. A fruitful approach towards these novel materials is based on the introduction of supramolecular cross-links into polymer frameworks, which, due to their reversible and dynamic nature, can be dissociated and reconnected multiple times to heal the damaged area. However, polymer toughness and autonomous healing exhibit an inverse relationship and, for practical reasons, the healing process must be activated in conditions that are different from the working conditions, or otherwise the material becomes too soft. Such activation is typically carried out through thermal heating, which accelerates the dynamics of the non-covalent bonds and enhances polymer chain diffusion. In LightHeal we plan to make a groundbreaking impact in the field of dynamic polymer networks by developing phtotoswitchable supramolecular cross-links that exploit the extraordinary attributes of Light as an external stimulus. Concretely, we want to be able to switch on/off cooperative noncovalent cross-links in polymer networks, so that the material can reversibly alternate, on demand, between a mechanically tough state and a soft, healable state. Moreover, we want to achieve such control with spatial precision, temporal precision, and wavelength orthogonality. For such goal, we will combine the knowledge of the host group in G-quadruplex polymer networks with the experience of the candidate in state-of-the art azobenzene photoswitches. LightHeal introduces fundamental challenges and unprecedented approaches in the expanding field of stimuli-responsive polymer materials with “smart” functionalities, and constitutes the best research scenario for the candidate to learn from different fields and further develop his career.

Mots clés : supramolecular polymers, g quadruplexes, photoswitches, self healing materials

Participants :
- Université autonome de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet SF-Leishyb (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

By transmitting hundreds of pathogens causing important human mortality and morbidity, vector insects are a major public health threat. Even if intrinsic insect parameters such as immune response are known to impact their vectorial capacities, the vector/pathogen interaction is still little understood. Phlebotomine sand flies are responsible for the transmission of Leishmania parasites, causing Leishmaniasis. This disease produces a wide spectrum of symptoms, due to a high genetic diversity of parasite strains. In addition to their clonal reproduction, Leishmania can engage in a cryptic sexual cycle resulting in hybrid progeny. Sexual mating is believed to be a major source of Leishmania genetic diversity, which drives changes in tissue tropism, pathology and drug resistance. Experimental generation of hybrids, until recently confined to parasites growing in the sand fly gut, is now possible to achieve in vitro. However, despite the possibility to culture high quantities of parasites, the frequency of hybrids generated in vivo is much higher than in vitro, showing that the vector gut environment is particularly adapted for Leishmania sexual mating. The mechanisms of Leishmania sexual reproduction and the parameters rendering the vector’s gut favorable to this process are currently unknown. I recently observed that pre-exposing parental parasite cultures to Reactive Oxygen Species (ROS) leads to an increased hybrid production in vitro, which led me to hypothesize that ROS, present in large amount in the sand fly gut, could be one of these parameters. Using a dual genetic approach applied on both the parasite and the vector, I aim to decipher the impact of the ROS produced by the sand fly gut cells on the engagement of Leishmania parasites in a sexual reproduction path. This project will generate important knowledge on the Leishmania/sand fly interaction and will set the stage for my future independent research group on the subject.

Mots clés : phlebotominae sand flies leishmania sexual reproduction vector borne diseases

Participants :
- Institut Pasteur (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet CLIMETAL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Freshwaters simultaneously receive a high diversity of contaminants, metals being amongst the most toxic. The growing use of metals for energy transition (e.g. electric vehicles, wind turbines, solar panels) is exposing freshwater ecosystems to unknown threats. These also suffer from the increasing frequency and intensity of extreme climate events (i.e. droughts and floods), which may cause hydric stress, physical abrasion, lower dilution, or contaminant pulses. These overall influence metal bioavailability and expose the biota to unknown toxicological effects. CLIMETAL will address these challenges by exploring the fate of metals used in energy transition, including those with understudied toxicity (lithium, rare earth elements, etc.), as well as their separated and sequential biological effects under the hydrological alterations associated to droughts and floods. CLIMETAL will investigate the influence of these alterations on metal bioavailability, and the subsequent consequences for their bioaccumulation and ecotoxicological effects. Bioavailability of metals will be estimated by modelling their chemical speciation and by measuring their labile concentrations, giving rise to a collaboration with physical chemists (= secondment). Metal bioaccumulation as well as biological and functional effects on freshwater ecosystems will be assessed using primary producers (biofilms) and primary consumers (invertebrates). These two biological compartments are connected and provide a complementary response to the metal exposure under distinct hydrological alterations. The proposal adopts an interdisciplinary approach involving ecotoxicology, environmental chemistry, ecology and modelling and combines complementary methods from laboratory (microscosm, mesocosm) to fieldwork. Data generated in CLIMETAL will contribute to fulfill the European Green Deal, which aims to reduce the impact of climate change and environmental pollution as well as protect ecosystems.

Mots clés : ecotoxicology metal hydrology biofilm

Participants :
- CERCA Institution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 209914.56 €
- University of Lleida (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet RESET (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

In-flight icing is a dangerous phenomenon that poses significant risks to aircraft safety, resulting from the accumulation of ice on surfaces due to supercooled water droplets. This ice formation can lead to reduced visibility, engine power loss, blocked probes and vents, and adverse effects on aerodynamics. Current methods for assessing icing scenarios rely heavily on costly wind tunnel and flight tests highlighting the urgent need for validated simulation tools. The existing reliance on experimental measurements as the sole "ground truth" in the validation process often leads to biased model assessments, compounding uncertainties that can adversely affect statistical reliability. This action aims to revolutionize the validation process of numerical simulations for in-flight icing by directly addressing these uncertainties and biases. I propose a novel statistical validation framework that incorporates uncertainties at every stage of analysis, enabling a clearer identification of physical model gaps. The proposed methodology encourages a dynamic and continuous exchange between experimental data and numerical models, allowing for mutual refinement. The research objectives include: (1) Characterizing uncertainties in experimental data related to ice accretion through focused campaigns, leading to reliable datasets; (2) Developing robust statistical metrics that comprehensively capture the variability inherent in both computational predictions and experimental outcomes; and (3) Benchmarking the application of these methodologies to evaluate existing ice accretion models. This innovative approach promises to bridge the gap between experiments and simulations, providing reliable tools for aerospace design and certification. If successful, this work will establish a new standard in certification by analysis, reshaping future validation practices in complex multi-physics applications such as combustion, heat transfer, and fluid-structure interactions.

Mots clés : in flight icing, validation, wind tunnel tests, certification by analysis

Participants :
- Université technique Carolo-Wilhelmina de Brunswick (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 217965.12 €
Projet MAIT-TraDe (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Mucosal-associated invariant T (MAIT) cells colonize mucosal tissues where they become tissue-resident and have important protective and homeostatic functions. MAIT cells are selected in the thymus by microbial metabolites presented by MHC-related protein 1 (MR1) on thymocytes thereby acquiring an effector phenotype (type 1 or 17). This project aims at elucidating mechanisms that regulate the last stages of thymic MAIT cell development, including their egress, and identify cues necessary for tissue colonization. Specifically, we will couple transcriptomics and thymus transplantation models to analyze canonical thymic MAIT cell development, thereby identifying new regulators of the MAIT1/17 fates, as well as to identify MAIT cells that recently exited the thymus and seeded mucosal organs, thereby identifying new regulators of tissue adaptation. These targets will be functionally tested in models combining CRISPR/Cas9 encoded by lentivirus with bone-marrow chimeras or adoptive transfers. Additionally, we will determine the identity and dynamics of MAIT cells exiting the thymus to colonize tissues by combining different experimental approaches including in vivo EdU/biotin labeling, thymectomy and blockage of thymus egress. Lastly, we will address whether MR1–microbial metabolites are required for the maintenance of MAIT cells in tissues at steady-state using mono-colonization/decolonization of germ-free mice and by conditionally ablating Mr1. Overall, this work will uncover fundamental mechanisms underlying MAIT cell development and tissue colonization. Albeit outside the scope of this work, it is possible that the mechanisms uncovered here may have implications in other innate-like T cells or for the establishment of mainstream tissue-resident T cells.

Mots clés : mucosal associated invariant t cells innate like t cells t cell development thymus mucosal immunology

Participants :
- Institut Curie (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €