Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CURV-FLEX-RIG (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

This research program will address the curvature properties of two important classes of complex manifolds: Kobayashi hyperbolic manifolds and Oka manifolds. These manifolds are characterized by a degree of holomorphic rigidity and flexibility, respectively, and have appeared in many branches of mathematics, from number theory to algebraic and differential geometry. A grasp of the curvature properties of these manifolds will offer valuable insights into their geometry, facilitate the generation of examples, and elucidate their relationship to important classes of manifolds---for instance, rationally connected manifolds, which play a central role in algebraic geometry. The experienced researcher (ER) has established major improvements in the main techniques that are used in the differential geometric study of Kobayashi hyperbolic manifolds, namely the Schwarz lemma. On the other hand, the field of Oka manifolds has seen tremendous growth primarily from the work of the host supervisor, who is the world leader in the subject, and a world leader in complex analysis more generally. The research program will not only merge these areas of expertise but also merge the complex analysis and differential geometry communities. The action will consist of a high transfer of knowledge to the ER, the host supervisor, and the host organization. The results of the action will be disseminated through online video platforms within which the ER has established himself as an experienced and proficient member.

Mots clés : kobayashi hyperbolic manifolds, oka manifolds, k hler manifolds, hermitian manifolds, schwarz lemma, wu yau theorem, canonical bundle, gromov s homotopy principle

Participants :
- Université de Ljubljana (Slovénie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171399.36 €
Projet GAPINCOMPETITION (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

In business life, academics, nonprofits, and politics, it is commonly observed that women enter competitive positions less often than men. This may stem mainly from two facts: 1) Women do not prefer competitive environments; 2) They are discriminated against in competitive environments. The literature starting from Niederle and Vesterlund (2007) focuses on the first fact. Niederle and Vesterlund (2007) show that although there is no performance difference between men and women, women prefer competitive environments less often than men. The aim of this project is to understand the (information) conditions under which females become more competitive. The promise of the project is important because it may be possible to increase the number of females in the competitive positions with a proper information design. In this project, I plan to use a similar set up to rank-order tournaments, i.e., performance is the sum of effort (transformation of skill) and chance. In the outgoing phase, I aim to understand how tournament entry decision differ across genders when subjects know both their own and their competitors’ skills but they have different types of information about the chance component: one being that the chance component is drawn from a known distribution (uncertainty), the other one being that it is drawn from an unknown distribution (ambiguity). This part of the project will be carried out in UCSD under the supervision of Prof. Uri Gneezy. I will then return to METU to continue the project for 12 months under the supervision of Prof. Serkan Kucuksenel. In the incoming phase, I aim to understand what should be the skill differences for males and females to encourage (discourage) females (males) to enter tournament by knowing that they have higher (lower) skill than males (females). Through the proposed research, I will be able to work with leading scholars in behavioral economics and my research agenda will advance with the help of new connections and skills.

Mots clés : behavioral economics, gender, tournaments, uncertainty, ambiguity

Participants :
- University of California System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université technique du Moyen-Orient (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171521.28 €
Projet FEATURE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

One of the grand challenges facing the high-energy physics community is understanding the far-from-equilibrium evolution of quantum chromodynamics (QCD). A recent innovation in the theory of far-from-equilbrium systems was the discovery of hydrodynamic attractors to which non-equilibrium solutions of microscopic configurations decay, losing knowledge of their initial conditions well before approaching thermal equilibrium.  This project will take the critical step to bring theoretical understanding to the level of complexity required for realistic phenomenology, by fully characterizing the properties of the QCD attractor without resorting to simplifying assumptions done in the current preliminary studies. This will be done via the inclusion of fermionic degrees of freedom and by relaxing simplifying spatial symmetries. This proposal is possible due to the mixing of perspectives and skills, from Dr. Alexander Soloviev's (the researcher) deep knowledge of attractors and the physics of heavy ion collisions, and Prof. Sašo Grozdanov's (the supervisor) extensive expertise of magnetohydrodynamics and non-equilibrium field theory methods. The researcher will undergo training at the University of Ljubljana, cultivating the necessary analytic and numerical skills to meet the research objectives of the project and advance his career. The new insight gained will be applied to the phenomenological context to elevate the dynamical freeze-out process into a far-from-equilibrium process, thus leading to the full exploitation of data at experiments in the Large Hadron Collider and Relativistic Heavy Ion Collider. The attained knowledge will be also used to probe the attractor near the phase transition, providing vital insight into searches for the QCD critical point. Furthermore, the gained insight into attractors will provide an avenue to integrate magnetohydrodynamics into descriptions relevant for heavy ion collisions.

Mots clés : quark gluon plasma, hydrodynamic attractors, far from equilibrium dynamics, magnetohydrodynamics

Participants :
- Université de Ljubljana (Slovénie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171399.36 €
Projet MagFetProg (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Obesity prevalence is increasing as well as the related metabolic alterations. Obesity and T2D increase the risk of pregnancy complication and affect offspring health through developmental programming effects. Obese patients with T2D frequently present Mg2+ deficiency. During pregnancy, Mg2+ needs increases, and its insufficiency may affect the mother and fetus, interfering with pregnancy development and offspring growth. Although it is known the relevance of Mg2+, its role in pregnancy is often overlooked and the underlying mechanisms that causes disturbances on Mg2+ homeostasis are unelucidated. Mg2+ homeostasis is carefully regulated. Among the channels are the cyclin M 1-4 (CNNM1-4), highly conserved molecules. Although it has been suggested that Mg2+ transport and homeostasis plays a key role in development, its regulation during development and in maternal-fetal communication is not fully understood. Fetal growth is closely related to the placenta capacity to transport nutrients and ions. At birth, the fetus makes a transition from using placental nutrient supply to utilize the liver. Thus, changes in maternal liver metabolism related to Mg2+ levels and signalling could affect the maternal metabolic state and negatively impact the developing fetus. This project aims to assess the role of Mg2+ homeostasis and transport through the CNNMs in programming effects in the context of maternal T2D and obesity. We will focus on the role of Mg2+ on fetal programming effects in a context of altered maternal metabolism and to evaluate the impact on offspring liver. In addition, we will evaluate the potential dietary intervention with Mg2+ supplementation for ameliorating offspring-derived effects. We hypothesize that maternal obesity leads to an altered environment that involves an impaired maternal hepatic Mg2+ signaling through the CNNMs that affects the metabolic fetal environment and the maternal-fetal interaction and programs offspring metabolic alterations.

Mots clés : endocrine, nutritional and metabolic disease, dohad, gene therapy

Participants :
- Center for Cooperative Research in Biosciences (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet SPIRAL (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The present project focuses on deeply comprehending the molecular basis of glycan recognition events by key protein receptors at atomic level, directly connected to processes related to immune response, infection and cancer. We will elucidate using Nuclear Magnetic Resonance (NMR) and other biophysical techniques the binding preferences of the recognition event between GD3 ganglioside and the Spike proteins of OC43 and HKU1 human coronavirus (HCoV) variants, along with Siglec-7. The role of Siglec-7 in inhibiting the HCoV viral infection will also be addressed. This research will make a significant and direct contribution by unveiling the roles of glycosylation patterns and cell receptors in HCoV infection mechanisms. Dr. Bermejo, the applicant, defended her PhD Thesis almost five years ago and was awarded a MSCA-IF fellowship for the past three years. During this time she has grown into an excellent researcher in chemical biology, possessing practical experience in organic and peptide synthesis, drug design, lipid nanoparticles formulation, cell culture and binding assays. Through the awarding of this fellowship she will join the lab of Prof. Jesus Jiménez-Barbero the Scientific Director of the host institution (CIC bioGUNE) and Leader of the Chemical Glycobiology lab. He is one of the best-known scientists in glycan research at the national and international levels. Thanks to this action, Dr. Bermejo will consolidate her multidisciplinary scientific proficiency, acquiring new competences in enzymatic synthesis and protein expression and purification and trend setting NMR concepts and techniques. She will contribute to the host with her expertise in glycan and glycoconjugates synthesis, and will bring her expertise in liposomal formulation, setting up a microfluidics device within the group.

Mots clés : carbohydrates, nmr, siglecs, viral spike protein

Participants :
- Center for Cooperative Research in Biosciences (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet TRAMAE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Keeping global warming below 2°C will require drastic reductions or even planetary-scale negative emissions that must be initiated within this decade to remove hundreds of gigatons of CO2 from the atmosphere. Ocean alkalinity enhancement (OAE) is one of the most promising methods to actively remove CO2 from the atmosphere whereby suitable rocks are extracted, pulverised, and dispersed over the oceans or land surfaces. CO2 is chemically absorbed during weathering and safely stored mainly as bicarbonate for geological timescales. However, the effect of introducing gigatons of alkalinity and dissolved metals in marine pelagic ecosystems remains mainly unknown. TRAMAE will be among the first to investigate some of the most relevant impacts of OAE and associated trace metals released by alkaline material, on coccolithophores. –calcifying marine phytoplankton– which are major drivers of the marine carbon and calcium carbonate cycles as they contribute 1-10% to marine primary production and ~50% to pelagic calcium carbonate sedimentation. The project aims at quantifying if and how an increase in alkalinity stimulates calcifiers and to what extent this would offset or strengthen the efficiency of OAE. Next to the focus on the calcification response towards OAE, TRAMAE aims to investigate the environmental effect of the most relevant dissolution products (i.e. trace metals) released by the minerals employed for enhancing alkalinity on the marine phytoplanktonic community. This is an urgent need to evaluate the possible risks in the real-world of the application of OAE. The fellowship will be carried out at GEOMAR (Kiel, Germany) where the proponent will be included in a team of experts on OAE in marine biology and geosciences. The results will be disseminated to raise awareness of global changes and ocean ecosystem dynamics. TRAMAE will be spearheading the assessment of OAE which may become an essential tool to counteract climate change.

Mots clés : ocean alkalinity, ocean alkalinity enhancement, carbon dioxide removal, phytoplankton, coccolithophores, climate change, carbon cycle, trace metals

Participants :
- GEOMAR Helmholtz Centre for Ocean Research Kiel (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet MPOPPE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Rice is a staple food for over half of the world’s population, making it vital to understand how pesticides affect its growth, productivity, and resilience. Current research often relies on single-omics methods, such as metabolomics or transcriptomics, which provide limited insight of the complete picture of the metabolic pathways impacted by pesticides. As a result, the complex interactions and adaptive mechanisms in rice remain poorly understood. Multi-omics approaches offer the potential to reveal these intricate metabolic networks and regulatory mechanisms affected by pesticides. The Multiomics Profiling of Plants in Polluted Environments (MPOPPE) Project aims to bridge this knowledge gap by investigating the molecular effects of commonly used pesticides on rice through an integrated analysis of transcriptomics, proteomics, and metabolomics. MPOPPE will examine gene expression changes, identify responsive proteins, and track metabolic alterations in rice plants exposed to selected pesticides. The project’s primary focus is to uncover the molecular pathways involved in stress response and detoxification mechanisms in rice. The MPOPPE project has three core objectives: (1) developing a multi-omics approach to elucidate plant adaptation and detoxification mechanisms in response to pollutants; (2) evaluating how diverse abiotic stress factors affect these mechanisms using multi-omics approaches; and (3) exploring the role of external detoxification agents in mitigating the harmful effects of pollutants on environmental systems. This research is expected to provide critical data that can guide the development of integrated pest management strategies to improve rice yield and promote environmental sustainability by advancing sustainable agricultural practices.

Mots clés : multi omics approaches pesticide molecular mechanisms stress response environmental agriculture, integrated management strategies

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €
Projet DEEPMARVELS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

In the face of emerging and pronounced global environmental change, identifying adaptive measures to prevent the irreversible marine biodiversity loss and associated ecosystem services is increasingly urgent. Marine Protected Areas (MPA) and Spatial Closures to Fishing (SCF) are key tools for preserving fragile benthic biodiversity hotspots in the deep-sea, particularly Vulnerable Marine Ecosystems (VME). However, MPA and SCF have been created without considering that VME distribution will likely change in both depth and latitudinal range due to climate change (CC), limiting effective long-term protection. DEEPMARVELS aims to predict VME distribution under present-day and future CC scenarios to inform adaptive management strategies. By integrating VMEs presence data from underwater imagery with local-scale bathymetric and oceanographic datasets into Species Distributions Model, DEEPMARVELS will provide a comprehensive understanding of how changes in the large-scale circulation patterns in the North Atlantic and North Pacific, driven by CC, will affect the composition and distribution of VMEs. The project focuses on 3 small-scale studies across a broad range of environmental variability in the Northern Hemisphere to assess how VMEs shift spatially and in depth in terms of foundation species and density. Models built under 2 future simulated CC scenarios will identify potential climate refugia, where projected conditions will remain similar to those of the at-present reference period, offering critical insights for future spatial biodiversity management. New methodological guidelines will be developed and presented to policy-makers establishing a design that can be replicated in other MPAs and characterized by a conceptual shift from static to dynamic climate-smart management measures, to ensure the success of the EU network of MPAs. DEEPMARVELS will greatly enhance my skills and expertise in VME dynamics, a blue-ocean niche with high scientific growth potential.

Mots clés : vulnerable marine ecosystems, benthic habitats, species distribution models, deep sea, remotely operated vehicle rov

Participants :
- Fisheries and oceans canada (Canada) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Department of fisheries and oceans (Canada) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 341898.72 €
Projet DECODE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The primary objective of this MSCA-PF proposal is to support Dr. Laura Pérez Alós in becoming an independent investigator by conducting the innovative DECODE project. DECODE aims to explore the role of the complement system in modulating the neuroprotective mechanism of mesenchymal stem cells (MSCs) in radiotherapy-induced brain inflammation (RIBI) in paediatric brain tumours. Specifically, the project will investigate the role of complement in RIBI using juvenile mice of both sexes, and the interaction between the complement system and MSCs will be assessed through in vitro cell culture models and in vivo juvenile mouse models of brain irradiation. Additionally, the project will evaluate the synergistic effects of complement modulators in combination with MSCs to mitigate the neurocognitive dysfunction caused by RIBI. The research will be supervised by Dr. Vivian Capilla González, leader of the Stem Cells and Translational Neurology group at the Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), a cutting-edge research centre that fosters excellence in scientific discovery in Spain. Dr. Pérez Alós, an expert in pharmacy and immunology, deeply focused on the complement system, will collaborate with Dr. Capilla González, who brings extensive expertise in brain irradiation mouse models and MSC modulation. DECODE ensures a multidisciplinary research approach, providing Dr. Pérez Alós with comprehensive training to facilitate her growth as a leader and independent researcher. The project’s findings are expected to pave the way for future collaborations and drive the development of MSC-based therapies for RIBI towards clinical application, ultimately offering safer and more effective treatment options for paediatric cancer survivors. The success of DECODE will create new opportunities for Dr. Pérez Alós to secure her long-term career as an independent investigator.

Mots clés : mesenchymal stem cells, radiation induced neuroinflammation, neurocognitive dysfunction, paediatric brain tumour, complement system

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €
Projet PEERS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Symbionts are essential components of healthy organisms, assuming functions often mediated by chemical communication. In aquatic environments, microbial primary producers such as phytoplankton possess complex epibiotic bacterial communities that contribute to their physiology by secretion of bioactive molecules. However, the role of symbiotic bacteria in mediating the host’s interaction with other coexisting microbes is poorly studied. PEERS’ aim is to unravel the key symbionts of phytoplankton mediating host interaction with zoosporic fungal parasites through the biosynthesis of antifungal compounds. Using a tripartite interaction model involving phytoplankton host, bacterial symbionts and fungal parasites, we will study (i) the diversity of bacteria associated with healthy and diseased host populations, and (ii) the symbionts’ biosynthesis of antifungal compounds. This study integrates molecular ecology, metabolomics, and bioactivity screenings coupled with advanced statistics and data processing methods. Aquatic microbial communities will be collected from the Baltic Sea during the secondment, where the phytoplankton-host and parasite interactions during fungal disease outbreaks are well documented. PEERS will address a fundamental ecological question about the role of symbiotic bacteria in driving host-fungal parasite interaction in the aquatic environment, providing critical knowledge for understanding future variations in aquatic biomes under current environmental changes. Additionally, it provides a perfect model system to discover antifungal chemical signals with industrial applications. PEERS offers cutting-edge training opportunities to generate results at the forefront of innovation in aquatic ecology and biotechnology. Moreover, it offers transdisciplinary networking possibilities supporting a One Health research approach, with significant impact on my career progression.

Mots clés : phytoplankton, zoosporic fungi, chytrids, antifungal resistance

Participants :
- Conseil national de la recherche (Italie) — Coordinator, beneficiary, Recherche, subvention : 209483.28 €
- Université de Turku (Finlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €