Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MUSiC ArT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

In the Arabian Sea, the South West Monsoon (SWM) is active during summer and drives the Somali-Arabian Upwelling System (SAUS). The SAUS brings cold, deep and nutrient-rich water masses to the Indian Ocean’s surface, fuelling siliceous microplankton or silicifiers. Silicifiers (mainly diatoms and radiolarians), are an important component of the soft tissue pump, a biological mechanism that lowers atmospheric CO2 concentrations. Despite the key role of this soft tissue pump in monitoring global climate and the socio-economic impacts of the SWM and SAUS in middle East and Eurasia, little is known about the monsoon, upwelling and soft tissue pump variability in strength relative to past climate and how they may evolve in the future due to global warming. To palliate this problem, MUSiC ArT proposes to use state-of-the-art technologies and methods to deconvolute the influence of climate on the SAUS and SWM intensity and associated-impacts on siliceous productivity over the last 150,000 years, covering the last interglacial period. The project aims to carry out innovative micropalaeontological and geochemical analyses on two sediment cores of the collections available at the Museum National d’Histoire Naturelle (MNHN, Paris, France). During the outgoing phase at GNS Science (New-Zealand), Artificial Intelligence and conventional microscopy will be used to generate census radiolarian and diatom counts. During a secondment at the University of Lausanne (Switzerland), isotopic ratios of 230Th and 232Th will be measured. For the return phase at the MNHN, diatom counts and high-quality imagery on microfossils will be completed and the isotope ratio of Silicon (δ30Si) and the Ge/Si ratio will be analysed on handpicked monospecific radiolarian and monogenus diatom samples. With this multidisciplinary approach, MUSiC ArT aims to couple AI, micropaleontology and geochemistry, advancing the Primary Investigator (PI)’s career by developing his unique researcher profile.

Mots clés : indian ocean, upwelling, soft tissue pump, radiolarians, diatoms, taxonomy, microscopy, artificial intelligence, geochemistry, isotopes, mass spectrometry, biogeochemical cycles, th, si, ge, c

Participants :
- Université de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Muséum national d'histoire naturelle (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 314329.08 €
- Earth Sciences New Zealand (Nouvelle-Zélande) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet QDHassay (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Nucleic acids are intrinsically polymorphic. Apart from the Watson-crick duplex, guanine-rich sequences can form G-quadruplex (G4) structures, which have become attractive targets for small molecule ligands. It is now proven that G-quadruplexes can form in cells. Today most biophysical and structural/ligand binding studies are carried out in dilute aqueous solutions and the presence of artificial crowding agents/cosolvents. Still, recent works suggest that the folding of G4s may differ in the cellular milieu context due to the agents' limitations. Thus there is an immense need for in-cell-based structural biology approaches. In the proposal, I aim to address critical milestones leading to the bioactive conformation inside the cell and the development of effective/specific G4 targeting drugs using an essential sub-class of G4 structures as a paradigm, namely quadruplex−duplex hybrids (QDH-hereafter). We will focus on low- and high-resolution spectroscopic approaches and mass spectrometry-based ligand screening assays characterizing ligand-QDH interaction. On the methodological part, we will develop in-cell NMR in "native" conditions (starting from unfolded conformation: denovo folding) and propose a ligand screening assay inside the cellular system. Our project will contribute to unveil fundamental principles of nucleic acid folding. It will also foster collaboration between two European institutes specialized in complementary biophysical and structural approaches to study biomolecular folding. In a nutshell, the Maria Skłodowska Curie fellowship will flourish my scientific excellence and the resilience needed for my original ideas to become a reality and communication and public engagement skills across cultures and disciplines.

Mots clés : nmr, in cell nmr, nucleic acids, quadruplex duplex hybrid, dna drug interaction

Participants :
- Université Johann Wolfgang Goethe de Francfort-sur-le-Main (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Masaryk (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166278.72 €
Projet RaCOON (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Forests cover more than 40% of Europe’s surface and are essential for biodiversity, provide fresh water, absorb carbon and prevent erosion. Yet they face detrimental effects of climate change, such as wildfires or outbreaks of the bark beetle. The field of robotics offers a pallet of tools to help manage and monitor forests, yet mainly by flying robots. Ground robots that could carry heavier equipment and last longer struggle in vegetation since their autonomy systems have been developed for obstacle-free scenarios (e.g., driving on roads). The research proposed here, “Radar Classification Of Obstacles in Nature (RaCOON)”, aims to enable the deployment of ground robots in forests by giving them the ability to decide which vegetation can be safely driven through. The applicant will deploy a new sensor modality, i.e. radar, and develop a novel sensor fusion system that will classify vegetation into the obstacle and non-obstacle categories. This additional information will allow ground robots to autonomously plan trajectories and navigate in vegetation. The problem will be approached first by exploring the possibilities of radars in a proof-of-concept experiment. Then, a forest robotic dataset will be recorded in various types of vegetation. The experience from the proof-of-concept experiment and the recorded data will motivate the design of the final sensor fusion system. The outcomes of RaCOON will be 1) dissemination of the new system and dataset to the research community and professional networks, 2) training of the applicant in the deployment of radars for mobile robots and 3) extending the applicant’s professional network and independent research capabilities, advancing him towards starting his own robust field robotics research group.

Mots clés : mobile robot, radar, autonomous navigation, mapping, forestry, outdoor, sensor fusion

Participants :
- Université d'Örebro (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
Projet IM-POWER (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The implementation of the energy policy to clean our energy system will lead to massive offshore wind power installations in the coming decades, thus causing the electricity grid balance to increasingly rely on intermittent renewable energy sources. Such dependence, and the increased electrification, leaves power grids vulnerable to the risk of negative impacts of climate-induced weather extremes. Nevertheless, the effects of extreme events on the reliability of electricity distribution systems remain an open question, and to address this point, IM-POWER is proposed here. The Action aims to develop a numerical integrated model to predict the power generation performance of emerging offshore wind technologies during storm conditions and anticipate their impact on power grids. IM-POWER will set a comprehensive numerical strategy to assess the power output of offshore wind farms that comprise wind turbines installed on floating platforms. High-fidelity modeling techniques for simulating marine structures and harsh marine conditions – involving wind effects, floating foundations, and power generators – will be combined. Three representative configurations of floating offshore wind turbines (FOWTs) will be arrayed into wind farms. To provide relevance to the layouts, their design will be tackled in cooperation with the world-leading project developer Hexicon AB (Sweden). Therefore, the computational tool will be used to investigate the power output of the FOWTs by assessing their transient response when the peak of storms (usually lasting three or four hours) hits the wind farm. Owing to the effort required by the numerical procedure, hardware acceleration provided by the National Supercomputer Centre (Sweden) will be used to perform the calculations. The knowledge gained from the power production variability during storms using IM-POWER, for different platform configurations, will permeate FOWT design and optimization procedures, and support power grid upgrades.

Mots clés : renewable energy wind energy floating offshore wind computational fluid dynamics power grid electricity distribution systems resilience and reliability smoothed particle hydrodynamics

Participants :
- Université d'Uppsala (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
- Hexicon ab (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet FlexSen (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Soft electronic devices are indispensable for the development of artificial skin due to their high stretchability and sensing functionality. Conventionally, to mimic touch and temperature sensing of mechanoreceptors and thermoreceptors, compliant structural design accompanied with signal transduction mechanism such as piezoresistive, capacitive, piezoelectric, pyroelectric sensing have been utilized so far. The design of these pressure sensors requires highly flexible and robust electrical properties of materials as active and supporting components. In addition, strategically engineered micro-structure is employed to enhance the sensing performance. In this spirit, flexoelectric material, which relates strain-gradient and electrical polarization, emerges as a naturally suitable candidates for flexible pressure sensors. The strain-gradient-induced polarization does not only distinguish flexoelectricity from the commonly used piezoelectricity but also widen the choice of electro-mechanical coupling materials, especially lead-free and bio-compatible materials that are crucial for the development of biomedical devices. Furthermore, flexoelectric effect exhibits size-dependent behavior, particularly at sub-micron- and nano-scale so that proper design of micro-structure can open an opportunity to a new type of pressure sensor. Therefore, this project aims to propose a novel design for electronic skin (e-skin) based on flexoelectric effect. Specifically, a comprehensive virtual design framework including simulation, characterization and experimental testing of flexoelectric-based sensor will be employed to evaluate key parameters such as sensitivity, limit of detection, linearity, response time and power consumption.

Mots clés : electromechanical, flexoelectricity, electronic skin

Participants :
- Institut de micro-électronique et composants (Belgique) — Coordinator, beneficiary, Recherche, subvention : 175920.0 €
Projet BRAVERY (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Leading to disability and morbidity, neurodegenerative disorders (NDs) have a profound socio-economic impact. Given the aging of the population, they are raising remarkable concerns. Several active compounds for NDs treatment showed promising results in-vitro but failed in-vivo due to unfavorable biodistribution and limited biocompatibility. The nanocarriers (NC) proposed in the last decade have certainly improved brain delivery of active compounds, however, the limited bioavailability of the drug and biocompatibility issues make NDs treatment still a hot topic in neuroscience. With BRAVERY, I aim to achieve the spatiotemporal controlled drug release improving the bioavailability of neuroactive compounds in the brain without causing neurotoxicity. To do so, I propose to develop a novel biocompatible multi-drug NC capable of efficiently targeting the brain and releasing the loaded drugs in a controlled manner in response to specific stimuli, after intranasal administration. The proposed NC has three fundamental features: 1) It is mucoadhesive; 2) It degrades in response to two specific stimuli that allow achieving a spatiotemporally controlled release of the carried drugs in the brain; 3) Both NC and products of its degradation are biocompatible, thus limiting neurotoxicity. The biocompatibility and biodistribution of the NC will be evaluated by in-vitro, in-vivo, and ex-vivo analysis. As a proof of concept, the carrier will be loaded with active compounds and the biological effect observed will be compared with the one achieved by the free drugs. The project could have an immediate impact on NDs treatment improving the biological efficacy of the anti-prion protein drug used in this project as model drug. Such a versatile biocompatible multi-drug NC will pave the way toward a new era of NDs treatments, with a remarkable impact on society and health care systems worldwide.

Mots clés : nanomedicine, controlled release, biocompatibility, biodistribution, brain delivery, cytotoxicity, in vitro studies, in vivo studies, neurodegenerative disease

Participants :
- Université de Trente (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Mario Negri Institute for Pharmacological Research (Italie) — Coordinator, beneficiary, Recherche, subvention : 172750.08 €
Projet InSilicoCAPP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Cholangiocarcinoma (CCA) is an aggressive cancer with a poor prognosis, requiring complete resection for a chance at a cure. Cold atmospheric pressure plasma (CAPP) has emerged as a promising, localized treatment that minimizes damage to healthy tissue, unlike chemo- and radiotherapy. However, the interaction between CAPP and tumors remains poorly understood, particularly in controlling electric fields and reactive species during treatment. Current plasma flow models are largely 1D, 2D, or axisymmetric, while 3D in silico models can better capture tumor heterogeneity and physiological conditions. This project aims to develop a novel, open-source, full 3D multiphysics and multiscale in silico modeling platform to optimize CAPP treatment for CCA. The framework will enhance our understanding of plasma-tumor interactions, enabling precise control of treatment parameters and maximizing therapeutic efficacy while minimizing damage to surrounding healthy tissue.

Mots clés : computational fluid dynamics in silico cold atmospheric pressure plasma optimization methods cholangiocarcinoma

Participants :
- Sorbonne Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Chypre (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 190219.44 €
Projet DeTaSci (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The proposed project ‘Developing talent in science: Breaking the gifted education taboo’ seeks to gain new insight of how to address gifted students’ needs in inclusive education (IE) systems. IE systems, described as ’one school for all’ aim to ensure education is accessible for all students, however in reality have focused on the needs of average or lower-achieving students. Gifted education (GE) has been considered elitist, even taboo, and thus the needs of gifted students have been largely neglected in IE policies and schools’ pedagogical strategies. However, individuals gifted in science are key persons to develop responses to societal challenges and to increase innovation and economic competitiveness – if the education system allows them to develop their potential into actual competencies. Neglecting gifted students’ needs may also lead to negative consequences such as underachievement, bullying, and depression. The project will include the perspectives of gifted and regular students, parents and science teachers, and compare the results from Sweden and Finland using mixed methods. It will examine how gifted students’ socioemotional and learning-related needs are supported in inclusive science classrooms and what are gifted students’ and their parents’ lived experiences of specific GE strategies, such as acceleration and grouping – two potentially very effective but understudied and underused strategies in inclusive GE. The project will also examine how science teachers support gifted students’ learning with regard to competence development teachers have had or wish to have, and it seeks to find and showcase the best practices in inclusive GE. The project will produce highly relevant scientific knowledge from the IE context and improve teacher education; strong research-based teacher education manifests in higher science competencies among all students. The impact will extend beyond the Nordic context, as IE has recently generated significant global interest.

Mots clés : talent development, gifted education, inclusive education, science education, teacher education

Participants :
- Université de Karlstad (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252180.0 €
Projet HIPERT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

This project aims to develop high-performance, low-cost and environmentally-friendly Half Heusler (HH) thermoelectric (TE) materials for waste heat recovery in mid-temperature applications. It is an interdisciplinary research program, combining research actions from five different scientific fields: Computational Materials Physics, Chemistry, Nanotechnology, Materials Science and Manufacturing Engineering. Theoretical approaches and calculations will support the experimental investigations for the discovery and development of new n- and p-type HH materials with the potential for high TE performances. A range of different strategies will be implemented in order to optimize their electrical transport properties and achieve in parallel high reductions in thermal conductivity through effective phonon scattering, targeting to efficiencies with TE figure-of-merit, ΖΤ, close to 2. The final objective of the project is the construction of a prototype TE device using the developed optimized materials and the evaluation of the final efficiency and produced power output of the device. The interdisciplinary nature of the project will give the researcher the chance to gain training and experience from diverse disciplines, learning new methodologies, expanding his scientific horizon, strengthening his professional maturity and becoming more independent for an Academic position. HIPERT will have a high impact on scientific community, while in log-term it is anticipated to be beneficial for the economy and society. The HIPERT research outputs will introduce new scientific concepts and will inspire further research for the development of high-performance thermoelectrics. In parallel, it is expected to open the road for the development of HH TE generators in industrial level, creating attractive opportunities for European SMEs and companies to be involved in large-scale R&D projects, aiming to bring HH thermoelectrics in the market as an efficient sustainable energy technology.

Mots clés : thermoelectric materials, half heusler compounds, nanostructuring, thermoelectric device

Participants :
- Aristotle university thessaloniki (Grèce) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Stavanger (Norvège) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École des mines et de la métallurgie de Cracovie (Pologne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Chypre (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 148488.0 €
Projet ALCOHEART (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Alcohol consumption is associated with an increased occurrence of arrhythmia and sudden cardiac death. Supraventricular arrhythmias, particularly atrial fibrillation (AF), are the most common arrhythmias associated with excessive alcohol intake, but ventricular arrhythmias have also been reported after alcohol intoxication. Alcohol-induced arrhythmias represent an increased healthcare risk for the patients, and if they do not self-terminate, hospital admission and subsequent cardioversion is necessary to restore the natural heart rhythm. Unfortunately, despite the known detrimental effects of alcohol consumption on human health and decades of extensive research in cardiac electrophysiology, the mechanism(s) by which ethanol promotes arrhythmias remain(s) poorly understood. This lack of knowledge considerably limits the ability to accurately identify individuals susceptible to alcohol-induced arrhythmias, and cardiac conditions that increase vulnerability to develop such arrhythmias. To unravel these mechanisms, the ALCOHEART project proposes a unique methodology that combines simulations in anatomically-accurate computational models of human atria and ventricles with the use of pharmacokinetic models that allow to simulate different alcohol drinking behaviours. The state-of-the-art computational models of atria and ventricles will allow to assess cardiac excitation and repolarization in 3 dimensions, and to characterize the contribution of ethanol to arrhythmia vulnerability in healthy and diseased hearts. Moreover, the simulations will allow to evaluate the role of different alcohol drinking behaviours between males and females, and of sex-specific differences in cardiac electrophysiology. Putting together leading experts in the field, the ALCOHEART project will offer new insights into arrhythmogenic mechanisms of ethanol, and will provide the researcher with excellent training for his future career.

Mots clés : arrhythmia, cardiac electrophysiology, computer simulations, alcohol consumption

Participants :
- Université de médecine de Graz (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Masaryk (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191918.16 €