Projet GLYCOVAX (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

GLYCOVAX is a network for the education of promising young scientists who will learn how to rationally design a next generation of well-defined and innovative glycoconjugate vaccines to improve current preventive therapies and to tackle unmet medical needs. Glycoconjugate vaccines represent the key for success of vaccination in children. The covalent linkage to proteins renders carbohydrates able to evoke a T-cell memory response. Current vaccines are prepared from heterogeneous mixtures of sugars linked by unspecific methods to the carrier protein giving complex mixtures of products. Due to this intricate structure, it has not been possible to apply a medicinal chemistry approach in the development of glycoconjugate vaccines and to fully understand their mechanism of action. Combination of novel approaches for glycan synthesis and site-selective conjugation methods now gives access to conjugates defined in sugar component and attachment site, thus leading to robust structure-immunogenicity relationship. Advancements in structural biophysics can be applied to select the optimal glycan antigen. By combining the beneficiaries’ expertise in carbohydrate synthesis, bioconjugation, high throughput screening, structural glycobiology, vaccinology and immunology, together with the experience in project management, GLYCOVAX will create a multidisciplinary environment where 14 young researchers will contribute to develop a novel route towards improved, safer and better characterized glycoconjugate vaccines, and contemporarily acquire transferable skills which will lead them to become the new leaders of academic or industrial research. The network will involve 9 academic groups and 2 industrial partners as Beneficiaries, and one SME as Partner Organization. The profound interaction between academy and industry will aid the students to get new concepts and visions for translating their ideas from the bench to the manufacturing of the next generation of glycoconjugate vaccines.

Mots clés : carbohydrates, glycoconjugates, carbohydrate chemistry, glycoscience, automated synthesis, bioconjugation, glycan microarrays, immunology, biophysics, vaccines, structural vaccinology

Participants :
- ALTA (Italy) (Italie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 262875.6 €
- CIC bioGUNE (Espagne) — Partner, beneficiary, Recherche, subvention : 247872.96 €
- Ludwig-Maximilians-Universität München (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 249216.48 €
- Leiden University (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 510748.56 €
- University of Lisbon (Portugal) — Partner, beneficiary, Recherche, subvention : 238356.36 €
- Glycouniverse gmbh & co. kommanditgesellschaft auf aktien (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- University of Rijeka (Croatie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 247761.0 €
- University of Milan (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 716837.0 €
- GlaxoSmithKline (Italy) (Italie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 516122.64 €
- Max Planck Society (Allemagne) — Partner, beneficiary, Recherche, subvention : 34613.4 €
- University of Manchester (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 280879.21 €