Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CYBERCOMM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The proposed project will address the hybridization of modern warfare, which has led to a multi-dimensional crisis both in Europe and worldwide after Russia’s invasion of Ukraine on 24 February 2022. Because these recent developments blur the dividing line between ‘war’ and ‘peace’, the project will focus on cyber warfare as a key component of multi-layered hybrid strategies employed by hostile state actors and organized criminality to undermine peace and security in Europe. Building upon the European heritage of partnerships, the main objective of this research is to develop an exemplary model of effective legal and cyber measures that can become a foundation for a common principled approach to digital-security and fundamental freedoms in Eurasian countries with varying political, social and economic settings. Aimed not only at EU member states, but also at other countries which seek closer cooperation with the European Union, the research methodology will use an interdisciplinary approach at the intersection of cyber security and law to contribute to activities that can prevent malevolent hybrid strategies from prevailing and setting an undesirable precedent for future warfare campaigns. As opposed to the predominant focus on economic, labour and social dimensions of new technologies, this novel research considers the implications of progress in terms of issues related to technological sovereignty, safety of critical infrastructure and joint defence capabilities. My integration in the interdisciplinary group on ‘crime control and security law’ at UiT the Arctic University of Norway will be instrumental in complementing my knowledge of European/International Law and transitional justice with the latest cyber security expertise, transferring it to Ukraine and other EU partner countries as well as reaching a professorship to train next generations of experts, whose intersectoral cooperation will lay the ground for a coordinated response to hybrid warfare in Europe.

Mots clés : cyber crime, crime control and prevention, security law, law of war, human rights, european law, international conflict, transnational criminality, organized crime, cyber security, digitalization

Participants :
- Université de Tromsø (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 210911.04 €
Projet PRE-EMHPT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Over the last year, a global mental health crisis has severely impacted a generation of children and adolescents, with 20% of EU youth experiencing a mental disorder by the age of 24. Despite calls by the European Child Guarantee to reduce this burden through early detection and intervention, there are still no reliable biological markers to identify children at risk of future mental health. While mental disorders are usually first diagnosed during adolescence, the brain mechanisms underlying them begin prior to their behavioural manifestations. Looking at brain development is a promising approach to predict mental health in children, as brain follows typical growth curves during childhood. However, previous neuroimaging studies have struggled to establish a consistent link between brain development and mental health due to inconsistencies in brain measure and mental health. The PRE-EMHPT project aims to overcome these challenges by applying standardized measures of brain growth in children to predict mental health in adolescence, and identify the key periods of brain vulnerability underlying these trajectories. It will harmonize the largest longitudinal brain imaging datasets in children from 24 cohorts, encompassing 18,000 subjects, to generate sex-specific standard brain measures for each age. From these measures, the applicant will define subgroups of subjects based on the similarity of the growth of their brain regions, and estimate their associations with mental health in adolescence. The specific periods in time increasing the risk of belonging to one subgroup will be estimated as well as the validity of the results in adolescents and young adults with psychiatric disorders. This work will be conducted over 24 months at Charité Universitätsmedizin Berlin’s Centre for Population Neurosciences and Stratified Medicine (PONS), under the supervision of Prof. Gunter Schumann.


Participants :
- Hôpital universitaire de la Charité de Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202125.12 €
Projet AurArt (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

AurArt investigates auditory perception in early modern religious art, by exploring the Catholic debate over the Gregorian definition of images as the "book of the illiterate" developed in Italy after the Council of Trent (1563). Drawing on a wide range of literary and figurative primary sources, such as treatises on the justification of images and contemporary Jesuit frescoes, the project demonstrates the close interaction between seeing, reading, and listening in the reception of sacred texts and pictures. By rethinking hearing in early modern religious art, AurArt seeks to fill both a thematic and a methodological gap in the emerging field of study at the intersection of art history, sound studies, and religion studies. The overall goal of the project is to offer a new acoustic understanding of early modern sacred images, which will contribute to the current transformative change leading to a new interpretation of art as a cultural phenomenon involving the whole body and its sensorium. My research will be supervised by Prof. Ralph Dekoninck, a specialist in the field of early modern religious art and literature, and an expert in artistic theories and sensible practices related to sacred images. The fellowship will be hosted at the Group of Early Modern Cultural Analysis (GEMCA) at UCLouvain and involves a unique two-way knowledge transfer based on sharing interdisciplinary methodologies for developing new sensory approaches to art history. The results will be disseminated through the publication of four articles, the development of a website and the organization of two international research workshops. AurArt also includes the design of a museum auditory device at the MuséeL of Louvain-la-Neuve, in collaboration with Muriel Damien (MuséeL/GEMCA). The device project involves a synergetic interaction between research, artistic creation, and sensory heritage mediation, with the aim of fostering an embodied acoustic experience of religious artworks accessible to all.

Mots clés : sound studies, sensory history, visual culture, sensory heritage mediation

Participants :
- Université catholique de Louvain (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet PEAK (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

PEAK investigates, for the first time, the pivotal yet long-overlooked role that Middle and Late Bronze Age Cretan (c. 1900-1450 BCE, aka ‘Minoan’ culture) mountain communities played in the management of large collective rituals held at mountain-top sanctuaries (‘peak sanctuaries’) and the subsequent influence the latter bore on ritual practices held in lowland centres (‘palaces’). Challenging traditional theories promulgating the passivity of upland populations to prevalent palatial control, the project traces the political agency of mountain populations through an innovative, interdisciplinary, and bottom-up analysis of ceramic figurine use at peak sanctuaries. Within this scope, PEAK aims to trace where the ritual participants came from, what they sought to communicate during the events, and how they bonded while negotiating matters of trade, defense and land division through participation in collective performances. Gained through an innovative combination of approaches from humanities (archaeology, anthropology), science (petrography, pXRF), and digital humanities (GIS, SfM) – for which premium training is undertaken at UNIVE and the BSA – answers to these questions bestow political agency to mountain communities and indicate the existence of a reciprocal power relationship the peaks and palaces maintained during the 2nd millennium BCE. Alongside revolutionising scholarly understandings of the structure of Cretan Bronze Age society, PEAK significantly enhances the candidate’s research capacities and professional profile through the acquisition of new widely-applicable research and horizontal skills.

Mots clés : cretan bronze age, mountains, marginalised communities, ritual, figurines, performance, iconography

Participants :
- Université Ca' Foscari de Venise (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209483.28 €
- British School at Athens (Grèce) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet MetEvoAMR (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Antimicrobial resistance (AMR) is a rising global health threat and rapid evolution of resistance against existing or newly developed antibacterial compounds is predicted to lead to 10 million deaths and $60 trillion of lost economic output by 2050. While resistance-conferring mutations, their inheritance and spread by horizontal gene transfer are increasingly well-studied, our understanding of “pre-resistant” cells’ survival and resilience in the presence of lethal antibacterial doses remains unclear. This proposal is stimulated by recent findings suggesting that the extracellular metabolic environment and metabolic adaptations play an overlooked role in transiently buffering antibiotic lethality and, therefore, increase the emergence of subpopulations of cells and their effective size that supports the evolution of antimicrobial resistance. In this proposal, I will systematically dissect mechanisms at work in subpopulations of “pre-resistant” cells of priority pathogens Pseudomonas aeruginosa and Acinetobacter baumannii that can transiently cope with antimicrobial treatment. I propose to combine my expertise in bacterial physiology with the Ralser Lab’s ultra-fast, massive-scale proteomics and phenomics technologies. I will systematically investigate the metabolic stress response in clinically relevant conditions, and identify the key metabolic and signalling processes that support the survival of subsets of challenged cells upon exposure to major classes of clinically applied antimicrobials. Finally, adaptive evolution experiments combined with CRISPR/Cas9 gene editing will validate causal effectors of identified tolerance mechanisms that precede the appearance of resistance-conveying adaptations. Here, I will acquire technical skills in innovative technologies and the host lab will benefit from my experience in working with pathogenic bacteria. I will lead public engagement efforts and disseminate scientific research outputs on an important global health issue.

Mots clés : molecular metabolism, antimicrobial resistance tolerance, metabolomics, mass spectrometry, stress response, bacterial physiology, adaptation, regulatory networks

Participants :
- Hôpital universitaire de la Charité de Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet PreVis (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

What we see at any given time is not solely determined by the information currently reaching our eyes. The visual system is indeed thought to leverage on perceptual history – i.e., the stimuli saw in the recent past – to contextualise and optimise perception. The incorporation of past stimulus information into perceptual processing has important consequences, shaping how we perceive external objects and events according to the context in which they are embedded in. Namely, perceptual history can bias perception in an attractive way, making a stimulus to appear more similar to its preceding one than it actually is. The nature and mechanisms of attractive perceptual history effects are however unclear, due in part to seemingly conflicting findings suggesting either that the bias is perceptual in nature, occurring in low-level sensory areas, or a cognitive effect based on decision-making. With PreVis, I will provide a new perspective on these effects, proposing and testing a novel hypothesis. Namely, instead of being uniquely based on past information as currently assumed, attractive perceptual history biases may entail an active predictive mechanism. In this scenario, the attractive bias would arise from a prediction based on past stimuli (rather than the past stimuli themselves) performed by high-level brain areas, and affect the processing of sensory information in lower-level areas. In PreVis, I will use psychophysical techniques coupled with electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), to test this hypothesis and assess the neural signature and correlates of perceptual history and predictive processes. The innovative perspective of PreVis represents an important step forward from the current state of the art, and the project has the potential to clarify the nature of perceptual history effects and the mechanisms involved in this fundamental process shaping perception.

Mots clés : perceptual history serial dependence perception vision predictive processing

Participants :
- Université catholique de Louvain (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet EUFREEDOMS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

EUFREEDOMS examines the philosophical underpinnings of the four fundamental freedoms of the EU single market (the free movement of goods, persons, services, and capital). While the legal literature on the four freedoms is huge, much less effort has been made to analyse the freedoms in philosophical terms. Philosophical debates have focused predominantly on the free movement of natural persons. Yet, there are many interesting questions about all the freedoms. How can we best interpret the rights protected by the freedoms? Which kind of justifications should be given of the four freedoms? How are EU citizens benefited by having each of the freedoms? How should we understand the relationships between the freedoms? is there a hierarchy between the freedoms? Is the free movement of persons worthier of protection than the free movement of capital? How should we handle conflicts between the freedoms and other values (e.g. social rights)? EUFREEDOMS is an interdisciplinary project that contributes to the political theory literature of the EU with an analysis of the philosophical foundations of the four freedoms, which will contribute to shed light on the nature of the rights protected by the freedoms, and hence also on the possibility of establishing a hierarchy between the freedoms, arguing that the free movement of persons is more fundamental than the other freedoms: indeed, that it should be considered a basic right. EUFREEDOMS aims to shed light also on the way in which the four freedoms should be balanced with other considerations (e.g. social rights). There are many areas where EUFREEDOMS can have considerable impact: for example, it can contribute to a better understanding of the shape that EU integration should take in the future, and to better legitimising the four freedoms in the eyes of EU citizens.

Mots clés : political philosophy of the eu free movement rights eu law european integration

Participants :
- Université catholique de Louvain (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
Projet Epi-BCE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cancer is one of the leading causes of death worldwide and its management remains challenging. Tumor evolution, the process of genetic and epigenetic divergence and selection of cancer cell clones in a heterogeneous tumor, is a key aspect of disease progression and therapy resistance. The main goal of this proposal is to expand our understanding of the biological mechanisms involved in these processes. So far, the role of chromatin regulation and epigenetics in tumor evolution remains poorly characterized and understood. This is particularly relevant in bladder cancer where mutations in chromatin regulation are very frequent and are associated with advanced and therapy resistant disease. Epi-BCE will advance the state-of-the-art through the discovery of epigenetic mechanisms that drive bladder cancer progression and chemoresistance in cell subpopulations, and tumors with chromatin deregulation. Specifically, I will utilize a carcinogen-based mouse model of bladder cancer that recapitulates human cancer stages from early to advanced and therapy resistant disease. I will perform transcriptomics and epigenomics at bulk and single-cell level at stages of disease progression. In addition, I will employ genetically engineered mice with ablation of chromatin regulation proteins, integrative computational analysis and functional genetic experiments to identify key mechanisms. Epi-BCE will be a platform for professional growth. I will receive technical training in experimental mouse models, bioinformatics, and 3D genomics through a secondment. I will engage in new professional networks and acquire transferable skills. Grantsmanship activities will support the fellow towards a path to independence. Overall, the proposed experiments will yield scientific knowledge and reusable datasets on cancer biology. These outcomes will promote and accelerate future research on cancer management and therapeutics.

Mots clés : tumor evolution tumor heterogeneity single cell multi omics cancer epigenetics bladder cancer model genetically engineered mouse models cancer therapy

Participants :
- Université de Göttingen (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Biomedical Research Foundation of the Academy of Athens (Grèce) — Coordinator, beneficiary, Recherche, subvention : 197263.68 €
Projet ECHOS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Active-edible materials applied in food packaging have great potential as a sustainable strategy for maintaining food quality: they act as a barrier to the outside environment and a vehicle for active compounds that can extend the shelf-life of food products. Agro-industrial byproducts represent a valuable source of active and functional compounds for packaging development, with great accessibility and low prices while decreasing reliance on fossil resources. Among the compounds present in agro-industrial byproducts, phenolic-carbohydrates bioconjugates have attracted a lot of attention in the last years due to their bioactive properties as antioxidant and prebiotic, which can promote a positive influence on human health. However, their application on the development of active edible materials for food packaging remains poorly explored. ECHOS project proposes an innovative approach using phenolic-carbohydrates bioconjugates in the design of edible packaging with improved performance combining the mentioned bioactivity with functional properties to form self-standing films and coatings. Two biorefinery approaches will be developed in the present study to add value to relevant agro-industrial biomasses; (1) the recovery of natural bioconjugates by green extraction techniques, and (2) the enzymatic cross-link of phenolic-rich fraction and exogenous carbohydrates. A comparative study will be conducted on the feasibility and sustainability of using natural and biomimetic bioconjugates as active packaging materials. The bioactivity of the materials will be continuously assessed on fresh food preservation, along with the health benefits associated with their intake e.g. prebiotic effects on gut microbiota. The ECHOS project will lead to an important advance in the use of phenolic-bioconjugates as building blocks in the future food packaging market aligned with the objectives of the European Green Deal initiative.

Mots clés : circular food systems bioactive materials edible food packaging dietary fibers biocatalysis

Participants :
- Fundacion aitiip (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- École polytechnique Chalmers (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
- Extractis (France) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet HOPES (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Recently, the growing popularity of internet of things (IoT) applications has garnered substantial interest in autonomous off-grid energy harvesters such as organic photovoltaics (OPVs) from indoor-available energy sources namely artificial lights. The success of IoT will rely on avoiding battery maintenance for the billions of sensors postulated to be deployed, using available renewable energy at deployment for powering the sensors. The discovery of novel organic materials and diverse device strategies led to a big leap in the power conversion efficiency (PCE) of OPVs up to 31% under indoor lights. Despite the augmented usefulness of indoor OPVs with record performance, several challenges thus far need to be attempted. The High-throughput optimization for indoor Organic Photovoltaic Energy Systems (HOPES) project introduces a novel concept of combining advanced high-throughput experimentation techniques with a standalone tunable light source. HOPES is interdisciplinary and multidisciplinary and includes the development of highly efficient indoor OPVs along with the scale-up property that is, integration of IoT devices with the high-performance OPV. In HOPES, the researcher will implement a computer-controlled light emitting source to achieve a desirable light spectrum by exploring a large library of illumination spectra. This will lead to achieving the highest possible PCE (> 40%) for a given OPV system. The traditional experimental techniques cannot meet the recent progress of indoor OPVs owing to their limitations of time and workforce. Thus, HOPES will explore a variety of materials at an unbeaten pace by combinatorial screening to reach the highest PCE in indoor OPVs. The researcher’s experience with the indoor OPVs will be combined with the host supervisor’s expertise in high-throughput experimentation to successfully implement HOPES. The advanced training gained during HOPES implementation will contribute to excelling the researcher's professional career.

Mots clés : high throughput optimization, organic photovoltaics, organic semiconductors, nanofabrication, evaporation, blade coating, surface morphology, photocurrent mapping, organic thin films, organic polymers

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
- Epishine ab (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €