Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet UNAT (Horizon 2020, appel à projets 2020)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : SIGNED

Nowadays, research focusing on control and use of nanomaterials in different areas including life sciences has become a key driver of innovation. UNAT project aims at a systematic interdisciplinary study of metal-carbon nanohybrides (NHs) for advanced theranostic application. Indeed, development of NHs based on organic & inorganic moieties can synergistically or antagonistically influence functional properties of engineered nanotheranostic medicines. UNAT will develop innovative approaches for synthesis and multi-functional application of ultra-small (<10 nm) carbon-based NHs functionalized with various metal atoms for diagnostics and therapy of cancer. In particular, carbon cores of NHs will be chemically synthesized from biomasses and bio-wastes. The combination of pre-clinical in-vitro & in-vivo experiments will allow to evaluate theranostic potential of the NHs. UNAT will associate an industrial partner from Greece (Bioemtech), a research and innovation center from Ukraine (Science Park) and 2 academic research groups from France (UCBL) and Italy (CNR). The uptake efficiency and specific localization of the NHs in biological cells depending on their intentionally designed surface chemistry will be studied in details. Extremely rich physico-chemical properties of the NHs will allow their application as universal multi-modal (MRI, PET, X-ray, Fluorescence, Photoacoustic) in-vivo bio-imaging agents. The multimodal imaging strategy will allow us to correlate the images obtained with the use of various imaging facilities to increase general reliability of visualization of the NHs localization in tumours. Various exciting electro-magnetic sources used for medical purposes will be simultaneously used for therapy of cancer tissues containing the incorporated NHs. Strongly complementary research experiences of the partners involved in UNAT and a high degree of cooperative integration between them will allow a deep scientific study of the theranostic potential of the NHs.

Mots clés : nanohybrids, bio imaging, nanomaterials for cancer therapy

Participants :
- National Research Council (Italie) — Partner, beneficiary, Recherche, subvention : 110400.0 €
- Taras Shevchenko National University of Kyiv (Ukraine) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 400200.0 €
- Bioemission technology solutions ike (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 151800.0 €
- Glincs (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 27600.0 €
- Université Claude Bernard - Lyon 1 (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 142600.0 €
Projet NOCMOC (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

Noč ima svojo moč [The Night has it might] (NOCMOC) [NIGHTMIGHT] project combines a strong awareness campaign embedding a major media campaign and a citizen science project with activities spread all over Slovenia. The core objectives of the NOCMOC project is to raise awareness about the research and its benefits, overcome stereotypes, stimulate curiosity all over Slovenia and excite youngsters to take up the research careers. The awareness campaign will comprise national TV broadcasts, radio broadcasts, press presence and a social media campaign, reaching 100.000 people. The innovative awareness campaign will be based on the Citizen Science Project – Chestnut tracking. We expect, over 1.000 groups, families and individuals will participate in the Citizen Science Project and experience the research methodology-hands on, and above all contribute to the basic research methodology of the real research project. The NIGHT activities will take place in 25 cities across Slovenia and will bring together over 30 research-related institutions to raise awareness about research and innovation, its social and economic benefits as well as its variety of careers. Over 30.000 visitors from different target groups will take part in the NIGHT activities spread all over Slovenia. Activities will combine science festivals on the main square of four cities, science shows, simulations, research days in primary and secondary schools, lectures and workshops in public spaces such as libraries, retirement homes and museums, science espressos, EU corners, open doors at the research institutions, science centre and cultural institutions and many more - altogether over 200 individual activities in 24 hours from day until night.

Mots clés : research, innovation, science communication, researchers, paticipatory events, citizen science project, science careers, research careers

Participants :
- Jožef Stefan Institute (Slovénie) — Partner, beneficiary, Recherche, subvention : 30625.0 €
- National Institute of Biology (Slovénie) — Partner, beneficiary, Recherche, subvention : 31250.0 €
- National Institute of Chemistry (Slovénie) — Partner, beneficiary, Recherche, subvention : 30500.0 €
- House of Experiments (Slovénie) — Coordinator, beneficiary, Recherche, subvention : 45000.0 €
- Tehniski muzej slovenije (Slovénie) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 32937.5 €
Projet DeepNOE (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Nuclear Magnetic Resonance (NMR) spectroscopy is one of the leading techniques for protein structure analysis. In contrast to other methods, NMR spectroscopy allows the measurement of the dynamics and structure of a protein under nearly physiological conditions, without the need for crystallization or freezing of a sample. Recent studies on exact Nuclear Overhauser enhancements (eNOEs), carried out in the laboratory of the host professor, have enabled distance measurements in proteins by NMR with accuracy of 0.1 Å. This allows to determine structures in solution and in living cells with unprecedented resolution. This biophysical achievement creates an outstanding opportunity for a computer scientist (the fellow candidate) to develop the first-of-its-kind model/algorithm that automatically transforms raw NMR measurements into high-resolution protein structures that reveal multiple simultaneously populated conformational states in atomic detail. This problem will be tackled with the use of deep learning (DL), a novel field in machine learning that has emerged after 2010 and has revolutionized data science and artificial intelligence. The project is divided into 3 parts. First, it is planned to investigate recent advances in DL to derive a model that extracts visual information from 2D and 3D NMR spectra. Afterwards, the proposed model will be integrated into CYANA to formulate a hierarchical DL/optimization routine, which automates all steps of protein structure solving. Finally, it is planned to explore the possibility of calculating protein structures directly from NOESY spectra, which constitutes a new protocol for protein structure solving by NMR spectroscopy. Summing up, the proposed DL approach has the potential to reduce the time required to solve proteins with NMR from months/years to days, while delivering very high resolution, multi-state structures. We expect this project to open new avenues in structural biology and drug discovery.

Mots clés : protein structure solving, machine learning, deep learning

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet LEVERAGE mRNA (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Nucleic acids are promising candidates for treating disease by stimulating, inhibiting, or replacing other nucleic acids or proteins inside of eukaryotic cells—a process known as “gene therapy.” However, methods to efficiently and safely deliver genes into cells are still lacking. The problem is that nucleic acids are not cell permeant and degrade before reaching the cytosol. One way to transport oligonucleotides into cells is by packaging them into hollow containers made of proteins, a method that has been successfully hijacked by viruses for a long time. Here, we propose to design and engineer an artificial proteinaceous container that (1) selectively encapsulates ribonucleic acids (RNAs) using a known RNA recognition tag and (2) delivers this RNA into the cytosol of mammalian cells. Protein engineering, which embodies both rational design and computational modeling, will be used to create the starting design of this artificial protein container. The initial design will be based on the protein lumazine synthase from the bacterial organism Aquifex aeolicus (AaLS), which forms small but highly symmetrical nanocompartments in bacteria and is very tolerant to genetic changes. To optimize this design, we will use directed evolution to induce an artificial selection pressure on a large population of distinct capsid variants, allowing us to obtain only the best-performing capsid variants: those that can enter and disassemble selectively inside of mammalian cells, thereby releasing the enclosed RNA molecules into the cytosol. New AaLS containers will be thoroughly characterized using cutting-edge technologies, such next-generation sequencing and cryo-electron microscopy. The ultimate goal of LEVERAGE mRNA is to use the designed and evolved capsids to deliver messenger RNAs (mRNAs) into cells that encode missing or dysfunctional proteins, for example in enzyme replacement therapies. If successful, this action will have lasting positive impacts on human health.

Mots clés : directed evolution, rna delivery, capsid engineering

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet DYNaMIC (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Nursing is the largest healthcare discipline worldwide and nurses play vital roles in the healthcare system. Clinical guidelines and protocols are available to provide safe and effective nursing care, but implementing these in routine care is not easy. So far, nursing implementation science has provided little evidence to guide the development of implementation strategies for influencing nurses’ professional behaviors. The proposed research addresses an urgent question in the field of nursing implementation science: What are effective strategies to change nurses’ behavior towards successful implementation of evidence-based interventions? The focus will be on ICU-nursing care and specifically on diaries kept by nurses in this setting. An ICU-diary of events during admission improves patients’ psychological recovery and prevents post-traumatic stress. In this action, the Consolidated Framework for Implementation Research will be used in combination with several original approaches and innovative implementation methods. First, a qualitative study will explore barriers and facilitators among ICU staff (nurses and physicians) and patients for implementation of the ICU-diary. Second, I will tailor my implementation strategy to the barriers and facilitators found, while extending traditional strategies with the involvement of patients’ relatives. Third, in a prospective implementation study I will assess implementation outcomes measures (fidelity with and coverage of implementation of diaries) as well as the clinical outcomes (e.g. anxiety, delusional memories, and PTSD) after ICU discharge. The research proposes a novel approach in a clinically relevant field. This grant would have a substantial impact on my short- and long-term scientific and career goals and will strengthen my scientific qualities. Undoubtedly, this action will boost the field of nursing implementation science in the EU member states, for example with regard to influencing nurses’ professional behavior.

Mots clés : implementation science, nursing science, intensive care

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172800.0 €
Projet SCAFFY (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : CLOSED

Obesity and cardio-metabolic disease represent major health problems with vast impacts on the European healthcare systems. Recent advances in tissue engineering and regenerative medicine can be used to design novel techniques aiming to boost human metabolism; thus being promising candidates for human metabolic disease treatment. However, the development of these techniques requires the creation of new technology and knowledge in chemistry, biomaterials, toxicology, physiology, molecular biology as well as business management and marketing. SMEs do not have the technical capabilities or the facilities to conduct R&D activities at the level of excellence required for such development. Academic institutions have the capacity and facilities to conduct research and design activities necessary to develop the concept into a market product. However, they do not have a viable supply chain to develop the prototype post project and to exploit the product in the market. To solve this intersectoral problem, the SCAFFY project will create an effective intersectoral co-operation between academia institutions and SMEs to advance the concept of bio-scaffold for brown adipose tissue regeneration. SCAFFY will put together knowledge, research expertise and resources from two large academic participants with business, market and commercialization experience from three SMEs to: i) ensure a high degree of collaboration between academic and industrial participants though Networking Activities, ii) go beyond the current state of the art though Researcher & Training Activities, iii) increase intersectoral transfer of knowledge though Workshop Activities, iv) ensure high level of innovation capacity though Innovation Activities, v) ensure communication to the scientific community and to the public though Dissemination and Outreach Activities.

Mots clés : bio scaffold, tissue engineering, matrigel, brown adipose tissue, uncoupling protein 1, nanotechnology, metabolism

Participants :
- Imedica sa (Roumanie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 189000.0 €
- Christos papadopoulos & sia oe (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 189000.0 €
- Technical proteins nanobiotechnology sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Noray Bioinformatics (Spain) (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 162000.0 €
- Vrije Universiteit Brussel (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162000.0 €
- University of Brescia (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 162000.0 €
Projet OSTtrans (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Obesity is increasing rapidly in EU, with about 50% of the population being obese. In addition to cardiovascular disease and type-2 diabetes, non-alcoholic fatty liver disease fatty liver disease (NAFLD) is a major obesity-associated chronic disease. Despite the high frequency of NAFLD, comprehensive research on its effects on hepatic biotransformation capacity is lacking, especially in human subjects. This project will use human liver tissues, human hepatocytes, organic solute transporter α/β (OSTα/β) over-expressing human cells and membrane vesicles, to evaluate the role of OSTα/β and other bile acid transporters in NAFLD, addressing a key question in current biomedical research: Can obesity lead to altered hepatic biotransformation and modulate the efficacy and safety of medications? The main objective is to elucidate the role of OSTα/β as a bile acid and drug transporter particularly in NAFLD. The hepatic expression of OSTα/β is normally low but dramatically increased in cholestatic conditions, even more than expression of other bile acid transporters. The project will focus on the proteomics of bile acid transporters and bile acid metabolome in NAFLD and NASH liver, regulation and mechanisms of OSTα/β transport, and the role of OSTα/β as a bile acid and drug transporter in the human liver. The project is strongly interdisciplinary, involving a combination of biochemistry, molecular biology, and analytical chemistry. The results will increase the understanding of NAFLD disease mechanisms, thus benefitting clinicians and authorities to ensure safe and effective drug therapies for the NAFLD population. This project examines one of the key priorities of European Commission, chronic diseases. In addition, the Applicant enhances her competences and the host widens its networks, thus supporting mutual knowledge transfer.

Mots clés : basolateral transport, bile acid, cholestasis, drug induced liver injury, dili, nash, nonalcoholic fatty liver disease, liver, transporter, hepatocyte, pharmacokinetics, pharmacogenetics, slc51

Participants :
- University of Eastern Finland (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 179325.6 €
Projet MicroILCs (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Obesity reaches epidemic proportions and currently represents a significant public health challenge. Curbing the prevalence of obesity is one health policy priority, whose achievement requires more effective preventive measures. A high-caloric diet and sedentary lifestyle are key determinants of obesity. The diet shapes gut microbiota composition, which may partly explain why microbiota alterations are associated with an obese phenotype in humans. These microbial alternations have been proven to contribute to energy metabolism and fat storage. This evidence has represented an unprecedented shift in the way we envision obesity management. However, translating this knowledge into microbiota modulation strategies that can be applied in the clinical setting needs a better understanding of the active players within the gut ecosystem, as well as, of the mechanisms underlying their dialog with the host. Preclinical studies show that the microbiota shapes immune responses beyond the intestine with consequences for metabolic health. This proposal aims to decipher the regulatory role of indigenous intestinal bacteria on the recently discovered innate lymphoid cells (ILCs). To achieve this goal, we will use the collection of intestinal human bacteria created in the context of the EUproject MyNewGut by the host institution, first, to identify those with ILCs stimulatory properties and second, to perform mechanistic studies in wild-type and mutant murine models of diet-induced obesity coupled to in vitro experiments with primary cell cultures. Overall, the objective of the MicroILCs proposal is to move forward in the understanding of the mechanisms whereby the gut microbiota controls the immune response to high-energy diets and affects the metabolic phenotype.

Mots clés : gut microbiota, microbiome, probiotics, obesity, nutrition, immune response

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 160932.48 €
Projet CRAS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Objectives of the current and future European CAP are to enhance the climate change resilience of European agriculture, increase climate change adaptation and protect biodiversity. Climate change Resilience of Agriculture System (CRAS) project aims, through an econometric and computational analysis, to better understand the contribution of agrobiodiversity to the resilience of agroecosystems and to the mitigation of the impacts of climate change on the agricultural sector. Objectives of the project are: 1. Estimating the contribution of agrobiodiversity to the economic resilience of the agricultural system applying the Ricardian approach. 2. Including agrobiodiversity into a CGE model to assess its role in smoothing climate change impacts on the agricultural sector, using parameters estimated in 1) 3. To evaluate the potential for adaptation policies favouring agrobiodiversity conservation to reduce climate impacts. The modified version of GE3AR model is used to assess the macro-economic (general equilibrium) implications of agrobiodiversity as a damage smoothing opportunity. In addition to policy advices, the project will contribute at exposing the debate on biodiversity conservation and climate change through an array of dissemination and communication efforts. During the outgoing phase, Dr. Lea Nicita will conduct the research and training at the Yale F&ES School, under the supervision of Professor Mendelsohn. Afterwards she will return to CMCC under the supervision of Professor Carlo Carraro. The project with its trainings improves her research and transferable skills, and extends her international networks through the contacts of the host and the beneficiary. By including versatile training-through-research, multiple dissemination and communication methods, public engagement and networking the project has a strong impact on the researcher’s career, on the future research collaboration as well as on the public interest.


Participants :
- Yale University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Euro-Mediterranean Center for Climate Change (Italie) — Coordinator, beneficiary, Recherche, subvention : 180369.6 €