Projet TRENDO (Horizon 2020, appel à projets 2020)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : SIGNED

Endometriosis is a sever disease affecting 10% of reproductive age women, characterized by the presence of endometrial-like tissue outside of uterus. Due to the associated pain, inertility and a small, but increased risk for developing ovarian cancer, its socioeconomic impacts are considerable, and have a profound effect on women’s mental and physical health. Endometriosis is characterized by a diagnostic delay of a decade, as its diagnosis is surgery-based, and all attempts to identify the non-invasive biomarkers have not been progressed beyond the discovery. Moreover, current treatments include only surgery or hormonal medications with significant side effects. In view of the above, the endometriosis care is challenging, and is hampered by the considerable heterogeneity of clinical manifestations. TRENDO consortium addresses the main problems in endometriosis diagnosis and therapy in a multidisciplinary and trans-sectoral effort, bringing together the clinical and translational science experts, and industry partners from six European and South American countries. We develop non-invasive biomarkers and testing, which shorten the diagnostic delay, and reduce the unequal access to expensive healthcare. These biomarkers are tested for the suitability as drug targets, to monitor treatment response, and to predict the personalized clinical recommendations. By combining the strengths of our partners, we provide novel tools addressing the most urgent priorities in endometriosis and to successfully translate our findings into novel therapeutic approaches. This challenging scientific task provides an ideal career-enhancing setting for young scientists, providing them with transdisciplinary and trans-domain training, and with essential transferable skills. The training program provides a new generation of researchers with a strong competitive advantage on the job market and increase European academic and industry competence in one of the under-investigated clinical domains.

Mots clés : endometriosis, reproductive medicine, gynecology, pain, microrna, adult stem cells, animal, models, uterus, proteoglycans

Participants :
- Consejo Nacional de Investigaciones Científicas y Técnicas (Argentine) — Partner, organization partner, Recherche, subvention : 0.0 €
- Medical University of Warsaw (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 27600.0 €
- Karolinska Institutet (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 55200.0 €
- Competence Centre on Health Technologies (Estonia) (Estonie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 73600.0 €
- University of Ljubljana (Slovénie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 27600.0 €
- Maastricht University (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 73600.0 €
- University of Münster (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 32200.0 €
- Oxprotect gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 9200.0 €
- Ipdx diagnostics ou (Estonie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 9200.0 €