Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet TIPAT (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Antimicrobial resistance (AMR) is an increasing threat to effectively treat serious bacterial infections. To this end, tailoring antibiotic treatments to individual patients is urgently needed to maximize efficacy while minimizing the risk of promoting further resistance. To enable development of innovative personalized antibiotic treatment strategies, quantitative understanding of the interplay between drug, pathogen and host is crucial. The Training towards Innovative Personalized Antibiotic Therapy (TIPAT) network will train inter-disciplinary specialists optimally equipped with a skill set to address this challenge. TIPAT offers a cutting-edge training-by-research programme for 15 Early Stage Researchers (ESRs) who will investigate translation and integration of biological and pharmacological data related to drug-pathogen-host interactions towards personalized therapies. Central to the TIPAT research and training program is the combination of state-of-the art quantitative modelling with approaches in clinical pharmacology, immunology and microbiology, which enables development of innovative methodology to personalized antibiotic therapies. The consortium unites a cross-disciplinary team of leading academic experts and inter-sectoral partners including SMEs, pharmaceutical companies and hospitals. Secondments complementary to ESR research projects will promote inter-professional and cross-disciplinary research and communication. The TIPAT integrated program is enriched with transferable, regulatory and entrepreneurial skills training delivered through themed Summer and Winter schools. The TIPAT network will deliver inter-disciplinary specialists in personalized antibiotic treatment strategies. The TIPAT training will strongly expand career perspectives of ESRs in academia, hospitals, industry or regulatory agencies, and develop scientific innovations to enable optimal therapy for individual patients to address current and future challenges of AMR-infections.

Mots clés : antibiotics, pharmacokinetics, pharmacodynamics, biomarkers, bacterial infection, antimicrobial resistance, therapeutic drug monitoring

Participants :
- University of Udine (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Jena University Hospital (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 505576.8 €
- Paul Ehrlich Institut (Allemagne) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 505576.8 €
- Leiden University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 796859.64 €
- Medical University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 792621.72 €
- University of Bologna (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 522999.36 €
- Uppsala University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 845948.88 €
Projet IDYEA (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Antimicrobial resistance (AMR) spread in the aquatic environment poses a growing public health risk with wastewater treatment (WWT), being the most important but still un-optimised barrier in confronting the global water and nutrient scarcity challenges. Europe’s Water Framework Directive aims to achieve good qualitative and quantitative status of all water bodies. Challenges to the effective separation and recovery of water resources from hazardous materials, notably, antibiotic residues and AMR in WWT were recently identified. In the past, AMR spread was experimentally assessed at static antimicrobial exposure levels that may suffer from lack of environmental representativeness as a result of significant variations in the emission of antimicrobials in urban catchments. IDYEA takes on this challenge by (i) experimental modelling of dynamics in the occurrence and fate of selected antimicrobials; and (ii) developing dynamic simulation models for predicting AMR spread at different time scales in WWT. The inter-sectorial and interdisciplinary IDYEA will be hosted at University of Bath, and supported by the Norwegian Institute for Water Research. It trains one experienced researcher in areas of process modelling, analytical chemistry, molecular microbiology and bioinformatics. IDYEA will offer excellent opportunities for mutual knowledge exchange and technology development. IDYEA’s success is based on achieving the project objectives via seven work packages, including laboratory- and full-scale experimentation, model identification and risk assessment. To provide techno-economic solutions to AMR risk assessment as well as optimised process design and operation, the expected main outcome comprises dynamic process rate and stoichiometric relations for AMR spread. IDYEA will disseminate results via public engagement, reaching out to especially young people, inspiring them to get involved with science to solve real-world problems, thus building our global water futures.

Mots clés : antimicrobial resistance dynamics, water quality process modelling, urban water management, wastewater treatment, resource recovery, risk assessment

Participants :
- University of Bath (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet PePiPOM (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Antimicrobial resistance is an increasingly serious threat to global public health and immediate action must be taken to prevent its ever-increasing spread. One approach to overcome this problem is the development of new materials and coatings with bactericidal action; in particular those which tackle biofilm formation specifically. By inhibiting the growth of biofilms, bacteria become more sensitive to treatment and resistance diminishes. The applicant has designed PePiPOM to develop peptide-functionalized polyoxometales (POMs) that possess synergic bactericidal activity. The PePiPOM materials combine the anti-aggregation activity of POM molecules (key to tackling growth of biofilm matrix) with the bactericidal effect of POMs + antimicrobial peptides (to rupture bacterial cell membranes and/or internalise and destroy bacterial cells). Central to the success of this proposal is a novel approach for the synthesis of POM-hybrids whereby an “on-POM polymerisation” will be used to produce peptide-POM hybrids. The design of the antimicrobial peptides will also play a key role in the success of the project, since they will provide the required properties for an improved and synergistic activity. The resulting PePiPOM biofilm inhibitors will be tested for both their anti-aggregation and antibacterial activity, and the most effective candidates will be evaluated as anti-biofilm agents on plastic and metal surfaces. The fundamental academic aspects of these results will be of interest to the chemistry and microbiology communities and their application of great relevance to industry and the general public. The PePiPOM MCSA will open new research horizons for hybrid materials with synergic antimicrobial properties, but also importantly, will offer a real boost in the career development of the applicant on her route to achieving her professional career objectives.

Mots clés : polyoxometalate, hybrid materials, biofilm, antimicrobial resistance, peptide engineering

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 172932.48 €
Projet CICCI (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Approximately ninety percent of all cancer-related deaths are caused by the spread of cancer cells to distant sites rather than the growth of the primary tumour. The process of metastasis formation requires the ability of tumour cells to spread from primary tumours, by invasion of surrounding tissue, and afterwards by spreading to distant organs in order to manifest its devastating consequences for patient survival. The series of distinct steps leading to the formation of metastases has been referred to as the “invasion-metastasis-cascade”. For many years there has been an absence of genetically engineered mouse models of invasive intestinal cancer to analyse the complex processes occurring during the invasion-metastasis-cascade and the presumably underlying mechanisms such as epithelial-mesenchymal transition (EMT), cancer stem cell populations and mutation rates in the intestine. Combining adenomatous polyposis coli (Apc)-loss with either p53 mutation or Tgf-β receptor (Tgfbr)-loss results in invasive intestinal carcinoma of mice. The host laboratory generated these two contrasting models of invasive adenocarcinoma, which will be utilized to generate an invasion signature of mRNA and miRNA expression to analyse the underlying processes and important players and targets for future therapies of this initial step of the invasion-metastasis-cascade. Additionally, by comparing the obtained expression profiles to previously published intestinal stem cell signatures and by using genetic labelling in carcinomas, I will analyse the cell culture and human tissue based theories, which indicate that invasive tumour cells, which underwent an EMT, display increased stem cell properties and numbers. This knowledge will generate important information for future cancer stem cell targeting therapeutic strategies.

Mots clés : stem cell biology, comparative transcriptomics, mouse genetics

Participants :
- Cancer Research UK (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 183454.8 €
Projet MAREA (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Aquaculture expansion is a necessary step to respond to increase protein demands while limiting the reliance on wild fisheries and imports.Bivalve aquaculture is considered to be one of the most sustainable, although some potentially negative environmental impacts arising from high deposition rates of faces and pseudofaces on the seabed have been identified. Habitat restoration management can be integrated within aquaculture practices to limit their negative impacts and it can bring positive environmental changes while obtaining both economical and cultural returns.This project aims to integrate restoration with aquaculture, namely the reintroduction of native flat Oyster reefs under mussels culture sites and harvest oyster spat recruiting as seeds in the original farm area to obtain economical returns and start a local oyster farming chain, while leaving the reef intact to provide ecosystem services. The main aim is to identify the best practices for this integration, in terms of size, stock densities and environmental conditions necessary to obtain maximum benefits in terms of both harvestable product and ecosystem services. This will be done combining modelling and experimental approaches, with a pilot site in the northern Adriatic sea. This approach will be included in the global environmental change scenario, and environmental optimals will be found where is possible to employ these strategies for maximum return in order to extend the theories beyond our study system. The results of this project will benefit mutiple stakeholders, from fishermen to policy to scientists working in similar areas. The outcomes will move forward the concept of integrating practices to obtain greatest sustainability without impeding economical advances. I aim to publish results in the form of scientific peer review articles and as a tool box guideline for best practices.

Mots clés : restoration, reefs, molluscs

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171473.28 €
Projet EASYTRAIN (Horizon 2020, appel à projets 2020)
Action : Doctoral Networks - Industrial Doctorates
Panel : Environment and Geosciences
Statut du projet : SIGNED

Aquaculture is the world fastest growing food production sector, providing over 50% of sea food, while capture fisheries remains static. However, there is increasing concern about its sustainable and profitable development. This challenge requires effective cooperation and communication between the academic and the private sector. The EASYTRAIN project tackles this challenge by developing innovative aquaculture systems based on the most modern techniques in the field of aquaponics using organic aquaculture feed formulas, which substitutes fishmeal by Spirulina and quinoa as filler. EASYTRAIN combines the expertise of two academic and four industrial partners from Spain, Portugal, the Netherlands and Italy, with complementary expertise in the field of plant and fish farming, feed production, aquaculture engineering and micro algae biotechnology. The outcome of EASYTRAIN will be 6 researchers with experimental and transferable skills ready to cope with the future challenges of the prospect aquaculture sector.

Mots clés : aquaculture, aquaponics, metabolic rhythms, chronobiology, organic fish feed, fish nutrition, fish welfare, microalgae, biotechnology, sustainable development, aquaculture engineering

Participants :
- Jardineria y viveros la noria sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 250904.88 €
- University of Murcia (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 250904.88 €
- University of Ferrara (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 261499.68 €
- Alga zyme factory srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 261499.68 €
- Landlng aquaculture bv (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 265619.88 €
- Sparos (Portugal) (Portugal) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 237720.24 €
Projet AQUAINVAD-ED (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks
Panel : Environment and Geosciences
Statut du projet : CLOSED

Aquatic Invasive Species (AIS) are on the rise due to the synergistic effects of climate change and habitat destruction. The impacts of AIS on Biodiversity, human health, and loss of ecosystem services are well known, but their control and management has now become a worldwide priority. Successful management of AIS is challenging because it requires several steps in succession: (1) early detection, (2) identification of routes of introduction and pathways of dispersal, and (3) development of efficient control measures. However, public awareness and stakeholder involvement are also critical .The main research goal of AQUAINVAD-ED is to exploit novel molecular advances combined with the power of citizen science to develop innovative methods of early detection, control and management of AIS. This will be achieved via a multi-disciplinary network of experts in invasion biology, aquatic biotechnology, citizen science and environmental policy working from 3 different countries. The inter-sectoral dimension of the consortium consists of fundamental and applied scientists from 3 universities, 1 technological institute, 2 government agencies, 1 NGO and 5 SMEs. AQUAINVAD-ED will catalyse research and commercial activity in the detection and management of AIS, as well as in the implementation of codes of good practice for the European industry and Government agencies. This will be achieved by training the next generation of researchers on the principles of invasion biology, providing them with the skills necessary to detect and quantify the ecological and socio-economic impacts of AIS and the ability to communicate science to the general public. The training program will be delivered through individual research projects, active participation in network activities and a unique combination of specialised courses, designed to increase employability in the consultancy sector, government, academia, and the water industry.

Mots clés : biological invasions, environmental dna, metabarcoding, citizen science, crowd data sourcing, impact and risk assessment of invasive species

Participants :
- University of Oviedo (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 247872.96 €
- University of Florence (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- Nemo nature and environment management operators s.r.l (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 258061.32 €
- Swansea University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 819863.64 €
- Natural Resources Wales (Royaume-Uni) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Neoalgae micro seaweeds products sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 247872.96 €
- Tecnalia (Espagne) — Partner, beneficiary, Recherche, subvention : 247872.96 €
Projet ArchFarm (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

ArchFarm aims to expand the methodological principles of funerary archaeology and apply this innovative approach to interpret Neolithic Near Eastern burials. Funerary practices provide a valuable insight into social organisation and ideology of past societies. A major deficiency is that the archaeological record only shows the final deposition of human remains. Funerary practices are not often considered as a dynamic process that consists of several stages over a length of time. In addition, a confident interpretation of funerary treatment before deposition is currently very difficult due to the lack of experimental research. In order to reconstruct the sequence of funerary actions, ArchFarm will develop and test a protocol for the identification of pre-depositional treatment such as different forms of mummification. During the outgoing phase, controlled and repetitive experiments of human body decay will be conducted at the Australian Body Farm, the only human decomposition facility in the world that is connected to an archaeological department and combines archaeological questions with forensic science. The new methods will then be applied to Neolithic Near Eastern burials which are known for body part manipulations such as skull removal. During the incoming phase, skeletal remains from several Neolithic Near Eastern sites will be analysed. The results will be combined with ethnological research to increase our understanding of social choices and ideology behind certain funerary actions. ArchFarm is an interdisciplinary study that will create methodological novelties relevant to several periods. Based on a combination of archaeo-anthropology, forensic science and ethno-archaeology, this study will produce a more holistic narrative of funerary practices. In addition, ArchFarm will create the opportunity for communication and outreach on the subject of ‘dying, death and mourning in past and present times’.

Mots clés : actualistic experiments, funerary practices, neolithic near east, pre depositional treatment, social differentiation, mummification, anatolia

Participants :
- University of Wollongong (Australie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Bordeaux (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 270918.0 €
Projet ArCH4ives (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Arctic landmasses and lakes release significant amounts of methane (CH4), a potent greenhouse gas that contributes to global climate change. Yet, the effect of rapid warming in the Arctic on the fate of CH4 emissions is poorly understood, particularly over decadal to millennial timescales. The recent advance of high-throughput sequencing and metabarcoding techniques to analyse ancient environmental DNA, or paleogenomics, from Arctic lake sediment has tremendously heightened analytical sensitivity and thus unlocked a wealth of new information on past ecosystems and their processes. I will combine this innovative approach to a robust paleoecological framework and multivariate analyses to study the drivers underpinning microbial assemblages involved in the cycling of CH4 during major periods of climate variability in Greenland since deglaciation. By using an important multi-site set of lake sediment cores spreading along major environmental gradients and collected by the Anthropocene-Quaternary Research Group, I will upscale the study from catchment to region and from the present Anthropocene (~last 150 years) to the early deglaciation of the Holocene (~11,700 years ago). This dataset will also enable me to control for the different catchment-specific processes that may have influenced microbial abundance, diversity and function in the past, and isolate the influence of climate on their ecology. This interdisciplinary approach will be supported by the analysis of additional paleoecological proxies for other important components of the carbon cycle in Arctic watersheds via collaborations with Canadian and Australian laboratories. While acquiring new expertise in cutting-edge paleogenomics and microbial ecology in world-leading research facilities at the Centre for GeoGenetics, I will advance paleoecology, gain significant new insights into the global carbon cycle and improve our understanding of the sensitivity of polar ecosystems.

Mots clés : paleogeonomics, edna, sediment, holocene, carbon cycle, microbial ecology

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €