Projet NO-CANCER-NET (Horizon Europe, appel à projets 2022)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

NO-CANCER-NET will focus on Triple Negative Breast Cancer (TNBC) and Nitric Oxide (NO)-related therapeutic development. TNBC accounts for 10-20% breast cancers and is characterised by diagnosis at an early age and an aggressive phenotype. It indeed develops incurable distant metastasis within the first 2-3 years in approximately 30% patients. Despite significant efforts, TNBC treatment is limited to surgery and chemotherapy laying bare the urgent need for new targeted therapeutic development. Our network has demonstrated an important role for inducible nitric oxide synthase (iNOS) and NO signalling in TNBC metastatic progression, with efficacy of iNOS targeting demonstrated in a phase I/II clinical trial of patients with distant metastasis. Based on NO’s yin/yang effect on tumour biology, iNOS/NO system can be targeted by either inhibiting iNOS and reducing the physiological levels of NO which drive tumour progression, or vice versa using NO donating drugs to increase NO to tumouricidal levels (similar to immune cells NO-mediated tumour targeting). The NO-CANCER-NET Doctoral Network (DN) addresses two fundamental gaps in European training: 1) a network where a core of Doctoral Candidates (DCs) can share a basic understanding of molecular target discovery, models of tumour biology assessment, drug synthesis and delivery, developing diagnostics, handling complex spatial imaging and omics expression data profiles; and 2) solid interdisciplinary training in experimental, computational and clinical research. NO-CANCER-NET will equip our DCs to understand the complexities of bench to bedside cancer research, the importance of an interdisciplinary approach and an understanding of the fundamentals of related disciplines. This will be of great importance in preparing DCs to work between academia, industry and in clinical healthcare providers.

Mots clés : nitric oxide, hydrogels, drug delivery, triple negative breast cancer, targeted therapeutics, 3d tumour models, engineering models

Participants :
- Université d'Udine (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 259437.6 €
- Galway Clinic (Irlande) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Sienne (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 259437.6 €
- 3dbiofibr inc. (Canada) — Partner, associated partner, Autres, subvention : 0.0 €
- École pratique des hautes études (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 282693.6 €
- Innovamol srl (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Conseil national de la recherche (Italie) — Partner, beneficiary, Recherche, subvention : 259437.6 €
- Université du Luxembourg (Luxembourg) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262620.0 €
- Trinity College (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 286488.0 €
- Université de Bologne (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Inprother aps (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Séville (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 251971.2 €
- Instituts américains de la santé (Etats-Unis) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Catalyze b.v. (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Galway university hospital (Irlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université nationale d'Irlande à Galway (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 572976.0 €
- Danish Cancer Society (Danemark) — Partner, beneficiary, Recherche, subvention : 301788.0 €
- Houston methodist hospital (Etats-Unis) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €