Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet DweLinks (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

DweLinks’ overarching goal is to explore the qualitative, geographical, and space-transformative characteristics of platform economy, and its development within complex, multi-leveled assemblages, in Athens, Greece and Berlin, Germany. More specifically, the project investigates the ways the emergence and establishment of digitally mediated, short-term renting (STR) markets, take place through i) the mobilisation and ii) the creation of ties and flows, among a variety of actors and networks. DweLinks’ major research hypothesis is that the development and establishment of STR activities is taking place through assemblages that employ, bring together, and mobilize human, material, and symbolic elements: urban and natural resources and assets (building stock, transport infrastructure, public spaces, sites of cultural and archeological interest, natural and cultural landscapes), labour, knowledge, services, historical meanings, and the notions of ‘sharing’ and ‘collaboration’. Through a qualitative methodology, heavily based upon assemblage thinking approaches, specifically Assemblage and Actor-Network Theories and the in-depth engagement with two study areas in each city, DweLinks will i) analyse and delineate the STR markets’ landscape in Athens and Berlin, through the exploration of their networks and actors, extent and limits, hybrid development, practices, role in socio-spatial transformations and differentiations, ii) enrich and inform ‘platform economy’ literature in the fields of urban studies, and social and economic geography, iii) inform policy agendas and regulatory frameworks and formulate policy directions, through the in-depth understanding of the development of the STR activity and its articulation in local sites and networks.

Mots clés : platform economy, short term rentals, housing, airbnb, booking, assemblage thinking, berlin, athens

Participants :
- Technische Universität Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162806.4 €
Projet DynOMIS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

DynOMIS aims to elucidate the antigen selection mechanisms of the adaptive immune system at the molecular level in the highly complex cellular environment. Major histocompatibility complex class I molecules (MHC-I) is a key mediator of adaptive immunity, the cell’s arsenal against infectious pathogens and malignant transformations. MHC-I present antigenic peptides to cytotoxic T lymphocytes at the cell surface, which in turn unleash their cytotoxic apparatus only when peptides from non-healthy proteins are recognized. This process is the result of an equally important peptide selecting function in the early secretory pathway, a mechanism that has not been clearly understood in spite of its fundamental role in vaccination. Deep understanding of the exact mechanisms that drive peptide selection by MHC-I will help to predict immunoprotective epitopes in infections and cancer, which will in turn pave the way for the development of more effective T cell-targeting vaccines and biomarkers to stratify patients’ suitability for immunotherapy. DynOMIS will employ a sophisticated, interdisciplinary approach that integrates quantitative computational systems modelling to identify molecular mechanism from cellular biochemical information, experimental investigation of the structure and dynamics of peptide-bound MHC-I over a large range of timescales, and state-of-the-art molecular dynamics simulations and free energy calculations to elucidate the thermodynamic basis of the peptide selection mechanism in the context of their interactions with cellular cofactors. To this end, DynOMIS will be carried out by an experienced researcher at a world-leading interdisciplinary group comprising molecular immunologists, structural biologists, computational chemists, and industrial partners with a strong focus on clinically relevant immunological research.

Mots clés : tapasin, peptide loading complex, protein structure, nuclear magnetic resonance, enhanced sampling molecular dynamics, free energy calculations, quantitative computational systems modelling

Participants :
- University of Southampton (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet NMRofLargeComplexes (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Dynamic properties of proteins are essential for their function. NMR can reveal protein dynamics in solution on a broad range of timescales and at atomic resolution. However, NMR studies of large proteins remain challenging since conventional NMR methods are constrained to small proteins. The aim of this project is to extend the NMR size limit to large protein complexes by combining recent developments in site-specific labeling schemes with novel NMR methods employing state-of-the-art spectrometers. This will facilitate the study of functionally essential but so far uncharacterized dynamics and substrate interactions of two large protein complexes, providing unprecedented insight into the relationship between dynamics, structure and function. Since most proteins are dynamic, extending the scope of protein complexes that are amenable to NMR study is of great interest to many areas of molecular biology. Studies will be conducted on the eukaryotic exosome, a 370 kDa soluble, asymmetric decamer involved in RNA degradation and processing, and the 80 kDa Na+/H+ antiporter NapA, an integral membrane dimer involved in ion transport. For the exosome, individual subunits will be 13C-methyl labeled; the employment of sophisticated NMR methods will then permit the detection of functionally essential dynamics and RNA-substrate binding patterns of the exosome. As NapA is a low-yield membrane protein, an inexpensive 19F-labeling approach will be employed to reveal global transport dynamics and local gating motions. Exosome production and all NMR experiments are to be conducted in Remco Spranger’s lab at the University of Regensburg, Germany. NapA will be produced during a secondment in David Drew’s lab at Stockholm University, Sweden. This newly established international collaboration will permit integration of methods and knowledge to study protein systems previously inaccessible to NMR, strengthen the profile of the applicant and foster research of the involved institutes.

Mots clés : nmr spectroscopy, protein dynamics, rna degradation, rna processing, exosome, membrane protein, transporter, site specific labeling, kinetics

Participants :
- University of Regensburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162806.4 €
Projet EIPOD4 (Horizon 2020, appel à projets 2018)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

EIPOD4 is an international postdoctoral fellowship programme embedded in the world-class research environment of EMBL. It fosters interdisciplinary and intersectorial research opportunities between academia, industry, clinics and museums via three available tracks (Academic, Industry, Clinical). The programme will host 60 experienced researchers recruited in 3 globally advertised calls following a transparent and merit-based evaluation and selection process with international peer-review. Fellows receive 3-year employment contracts to complete their self-designed interdisciplinary research projects. They develop interdisciplinary research skills and complete a mandatory training portfolio targeting transferable skills. A dedicated career development service and career secondment opportunities allow EIPOD4 fellows to further develop core competencies and enhance their networking skills. They are part of EMBL’s established Second Mentor programme and develop their own mentoring skills via the new EIPODs Inspire scheme where they support junior colleagues from less-represented countries. The programme aims to educate future scientific leaders with a strong sense of their responsibility to society. An important aspect of this is to engage in dialogue with the general public. The project partner, the Natural History Museum in London, will provide fellows with science communication training. Fellows will also have the unique opportunity to participate in one of the museum’s high profile public engagement events. EIPOD4 supports the increasing diversity of career paths in Europe’s research landscape. The programme will increase the visibility of the European Research Area as an attractive destination for experienced researchers to receive valuable and innovative training. As many of the globally recruited fellows stay in Europe following their postdoctoral fellowship they will contribute their skills to positioning Europe as a research and innovation leader.

Mots clés : interdisciplinary, intersectorial, international, academia, industry, clinic, museum, research and career secondments, training and career development, open science, research integrity, public engagement

Participants :
- European Molecular Biology Laboratory (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 6620400.0 €
Projet ENART (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

ENART is an integrated research and training programme for innovative knowledge transfer and career development. It will be implemented at the Department of Society and Global Studies at Roskilde University, Denmark (Beneficiary, host of the Incoming Phase), the Department of History of Art at the University of Michigan, USA (Partner Organisation hosting the Outgoing Phase), and SALT, research and exhibition centre in Istanbul and Ankara, Turkey (host of the intersectoral Secondment). The interdisciplinary constellation of these organisations and the supervision they provide complements the researcher’s own art-historical formation and endorses her research project in transregional Islamic Art History around which ENART’s comprehensive dissemination and public-engagement activities are built: The research project is entitled “Engagement Art: Regional Islamic and Global Pragmatist Aesthetics”. “Engagement art” is a new concept that this project introduces in order to define a hitherto overlooked approach to art. This approach conceives of art as a practice and medium which is continuous with everyday life. This project asks what ideas informed engagement art and what practical and historical circumstances interfered with its development and actual enactment. To answer these questions the project traces the development of engagement art from its conception in Istanbul in 1909 to its implementation at the Art-Craft Department in Ankara in 1932. Thereby the research centres on the modes of confluence of regional Islamic and global pragmatist aesthetics. Apart from introducing a new concept to Islamic Art History, the project seeks to develop a new method for the study of non-canonical art and strengthen ties between the history of art made in and outside of Europe, as well as between Art History and its subdiscipline Islamic Art History. The aim of the project is to contribute to the development of an art historiography worthy of a diverse and inclusive society.

Mots clés : modern islamic art history, pragmatism, non canonical art, knowledge mediation, late ottoman empire, early turkish republic

Participants :
- Roskilde University (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 278227.8 €
- University of Michigan–Ann Arbor (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet EPCFG (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

EPCFG explores how populations in three provincial European cities (Leipzig, Germany; Lille, France; Manchester, England) understood and responded to the experience of globalization. The period of focus is 1880-1914, a critical phase in the history of the phenomenon, sometimes known as 'the first globalization'. A confluence of developments in travel, communications, trade, and cultural exchange led contemporaries to observe that the world was 'shrinking', increasingly understanding themselves and their societies to take shape in a global, not national or European, context. EPCFG has the following objectives. 1. To understand how the interlinked phenomena that constituted globalization were understood in provincial places, that are not typically the focus of histories of globalization, thereby refining historical understandings of the phenomena and the paradigm in general. 2. As such EPCFG responds to a prominent criticism of globalization as a historical paradigm, namely that historians have mainly analysed it at the global scale, failing to understand its multiple local meanings. These two objectives, elaborated with further concrete research actions in Part B of this proposal, will be achieved through a program of training with the supervisor and other experts in global urban history at the host institution, and archival work in the three cities. Archival work, and ultimately research outputs from the project, will be organised round three thematic case studies, each of which will be applied to all three cities. The case studies are A. discourses surrounding travel and transport, especially large projects of transport infrastructure; B. the global flow of commodities and the cities' participation in industrial production; C. the gathering and dissemination of news and information about events across the world, both through local newspapers, and means such as the composition and performance of poetry and song.


Participants :
- Freie Universität Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 159460.8 €
Projet EQUIANFUN (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

EQUIANFUN is a strategic research and training alliance I have assembled to catalyse the development of my new career path in comparative herbivore gut microbiology, and addresses a major nutritional challenge facing the equine community. The hindgut microbiota of equines enables forage utilisation; however, the limited efficiency of this process currently requires that the diets of many equines are supplemented with energy-dense concentrates in order to meet their dietary energy requirements. This practice can disturb the equine hindgut microbiota, resulting in the development of gut-mediated diseases which are a major health and welfare issue and economic cost to the equine community. Despite the fact that anaerobic fungi (AF) are the most effective of the fibre-degrading gut microbes, they have been largely overlooked in equine gut microbiology studies to date. Therefore research into this under-explored area will significantly advance the ability to increase the efficiency of forage utilisation in equines, minimising the need for concentrate supplements. Drawing on my core skills base, and utilising internationally leading expertise and facilities in gut microbiomics and animal nutrition at Wageningen University, EQUIANFUN establishes new baseline knowledge of the phylogeny, community structure, physiology and nutritional impact of equine hindgut AF. In addition to generating top quality research findings of applied impact, EQUIANFUN deepens my skills and competencies whilst broadening my research expertise and network beyond its current rumen focus. Furthermore the integrated role of the two partner organisations, Utrecht University and the Donkey Sanctuary, widens the scope of EQUIANFUN to also include the health and welfare of all domesticated equids. In summary, EQUIANFUN is pivotal to the development of my new career path and ability to attain professional maturity as an internationally leading researcher in comparative herbivore gut microbiology.

Mots clés : equine, anaerobic fungi

Participants :
- Wageningen University & Research (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet LSST-minimoon (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Earth's minimoons are a transient population of asteroids which occasionally become gravitationally bound to the Earth for a limited period of time. Their physical characterisation on a population level can lead to a thorough assessment of the population of smallest asteroids, i.e., those with a diameter smaller than 20 metres. This little-studied population of asteroids is important, on the one hand, for resolving the fundamental asteroid-meteorite linking problem, with implication for the formation of the solar system, and on the other hand, are a constant source of local scale threat to Earth’s biosphere. Due to their easy accessibility by spacecraft and the large amount of time that they spend in the vicinity of the Earth, minimoons are good targets for asteroid in situ resource utilisation, or for space missions that could retrieve an entire asteroid to Earth for laboratory analysis. The primary aim of this project is to build a dedicated tool to extract the possible minimoon detections from the data stream of the upcoming Large Survey of Space in Time (LSST), which will be the only facility able to detect minimoons on a bimonthly basis. However, even for LSST, minimoons will be on the edge of its detection capabilities since the general solar system processing tools are designed for a general case of moving objects. Minimoons, due to their exceptionally rapid movement and narrow windows of detectability require special attention. Outputs will include a peer-reviewed article, and a software package to enable the discovery of minimoons on an order of magnitude greater scale than with the standard LSST processing tools. In line with Marie Sklodowska-Curie Action objectives, the project will enable transfer of knowledge and interdisciplinary skills of mutual benefit between the applicant and the host organisation, enhance the contact networks of both, and strengthen the future career opportunities of the applicant through establishing international collaborations.

Mots clés : small solar system bodies, asteroids, temporary moons, near earth asteroids, astronomical software

Participants :
- Queen's University Belfast (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet StressEBOV (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Ebola virus (EBOV) is a highly pathogenic filovirus that causes severe haemorraghic fever and killed over 11,000 people during the recent epidemic in Western Africa. Although potential vaccines and drugs are being tested, no treatment has been approved. Therefore, understanding the cellular regulation of EBOV replication is fundamental to develop novel treatments. EBOV is a nonsegmented negative-strand RNA virus for which research is limited to BSL4 laboratories. However, a recent reverse genetic system using tetracistronic transcription- and replication-competent virus-like particles (trVLPs) allows modelling of the entire EBOV life cycle under BSL2 conditions. The EBOV genome is transcribed and replicated by the viral polymerase complex but the regulation of these processes remains poorly characterised. EBOV RNAs can also trigger antiviral responses via cytoplasmic RNA-sensors RIG-I and PKR, the latter also promoting stress granule (SG) formation. While EBOV inhibits RNA-sensing, the impact of SGs on EBOV is unknown. Therefore, I will investigate the role of cellular stress responses on EBOV replication and their potential counteraction by the EBOV VP35 protein using the trVLP system. Firstly, I will analyse the impact of SGs on EBOV replication by overexpression and CRISPR/Cas9 depletion of SG proteins. Using a panel of VP35 mutants, I will also investigate its potential to counteract SGs by automated flow cytometric image acquisition (Imagestream). Secondly, I will identify the EBOV polymerase complex interactome during infection using two distinct proteomic approaches: co-purification with a VP35-GFP fusion protein(GFP-trap) and VP35biotin-ligase proximity tagging (BioID2). Candidate VP35 cofactors will be validated by biochemical interaction, CRISPR-knockout and live cell microscopy to determine their role in EBOV replication. In summary, this project will increase the understanding of EBOV replication and identify new therapeutic targets.

Mots clés : ebola virus, stress granules, restriction factor, host cofactor, high throughput screens, crispr, cas9 knockout

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet PostGro (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Economic growth seems unlikely to continue at current rates, if at all. But we currently do not have a plan of how to manage a postgrowth economy. This represents a major impediment to formulating policies for how the EU may best pursue its objectives for development, environmental protection, and the elimination of poverty in a future postgrowth economy. There is debate over whether our current economic system based on interest-bearing debt can be made viable postgrowth, and evidence that even slowing growth leads to increasing inequality. Here, I propose research to integrate existing theoretical research into postgrowth viability with research into measures to prevent inequality from increasing. Since no industrial economy has yet experienced prolonged periods of very slow or negative growth, I will test the predictions against historical case studies. The project will achieve four objectives: to identify the parameters in which a postgrowth economy is viable; to identify the parameters in which continually increasing inequality is also avoided; to test these parameters against historical case studies; and to draw on these results to evaluate policies for producing a postgrowth economy that is both viable and avoids inexorably increasing inequality. The fellowship will allow me to broaden and deepen my knowledge of ecological economic approaches to postgrowth whilst bringing my knowledge of property economics, comparative institutions, and historical postgrowth to my hosts at ICTA. We will disseminate the results to academics and policy makers, with the historical aspect making quite technical debates much more accessible for communication to a wider public. The fellowship will place me, and ICTA, at the forefront of the emerging field of theoretical and historical postgrowth research. I have developed a realistic implementation plan together with my hosts at ICTA, a world-leading centre for research into postgrowth.

Mots clés : political ecological economics, ecological macroeconomics, postgrowth, degrowth, sustainability, institutions, property, distribution, inequality, interest, debt, wealth, capital

Participants :
- Autonomous University of Barcelona (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €