Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet AdaptEconII (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks - Joint Doctorates
Panel : Environment and Geosciences
Statut du projet : CLOSED

The present economic model of permanent growth is unstable and leads to cycles of growth, peaks and crashes. We propose to contribute to developing new economic thinking based on knowledge of global resources availability. The Adaptation to a New Economic Reality (AdaptEconII) project is divided into three parts: 1. Sustainable resource management; 2. Integrated economic systems assessment; and 3. Integrating society and economics. These components will be combined to form an overarching economic model built on socio-environmental-technical (SET) system analysis of causal links and feedback structures and system dynamics. A simple prototype of such a model (WORLD) has already been built by the applicants and tested on historical data. Twelve Early Stage Researchers (ESRs) will be trained to obtain European Joint Doctorates at three universities: University of Iceland (Reykjavik, Iceland), Stockholm University (Sweden) and Universite Blaise Pascal, Clermont-Ferrand (France). The ESRs will have secondments in research institutes/NGOs/SMEs in Germany (GWS and Wuppertal Institute), UK (New Economics Foundation and Schumacher Institute) and Sweden (Swedish National Defense College). All of the ESRs will have a career plan and be trained in system analysis and system dynamics in addition to conventional and biophysical economic paradigms. They will be presented with aspects of resource availability, links between resources and wealth, the rise of new and/or rediscovered values and realization of our interdependent world, new development paradigms, political and industrial ecology, as well as science for sustainable society and transferable skills. AdaptEconII will train ESRs in new economic thinking and the goal is for them be at the forefront of innovative economic thinking in the EU and the world.

Mots clés : evidence based policy, limits to growth, sustainability

Participants :
- Gesellschaft fuer Wirtschaftliche Strukturforschung (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Wuppertal Institute for Climate, Environment and Energy (Allemagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Université Clermont Auvergne (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 1051502.4 €
- Stockholm University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 1072447.93 €
- New Economics Foundation (Royaume-Uni) — Partner, organization partner, Recherche, subvention : 0.0 €
- University of Iceland (Islande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1076581.44 €
- Swedish Defence University (Suède) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- The schumacher centre ltd (Royaume-Uni) — Partner, organization partner, Recherche, subvention : 0.0 €
Projet SSINGERG (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Statut du projet : CLOSED

The present project aims at the preparation of synthetic nanoreceptors exhibiting glycan epitope recognition in glycoproteins, identified to play a critical role in cell biology and diseases. Such nanoreceptors, behaving like antibodies, may cope with the current limitations in the essential step of enrichment of specific glycan subclasses, within studies of the glycoproteome. The preparation of the receptors will proceed through solid-phase synthesis of imprinted polymer nanoparticles, with the potential to deliver entities with size, specificity and solubility characteristics comparable to antibodies. The solid-phase synthesis of NanoMIP will require the immobilization of important monosaccharides (N-acetylglucosamine, N-acetlgalactosamine, mannose), widely found in glycoproteins, onto supporting beads. Several synthetic routes will be studied for the immobilization onto silica or plastic beads . In a reactor, built as a controlled temperature glass column filled with the beads containing immobilized monosaccharide, criteriously selected polymerization or sol-gel mixtures will generate the nanoMIPs, with subsequent selection of the highest affinity particles. The optimum combinations of solid-phase/imprinting protocol will be screened from a myriad of nanoMIPs prepared in different conditions. The performance of the nanoMIPs will be ascertained by setting a competitive enrichment protocol consisting of the incubation with a mixture of N-acetylglucosamine-, N-acetylgalactosamine- and mannose-containing glyproteins and a non-glycoprotein. Sorption isotherm data will be used to derive important binding features such as capacity, binding affinity and selectivity. Patentable robust solid-phases and imprinting protocols, either in standalone or combined manner, are planned outputs of the project, which may, in the near future, be incorporated into existing automated solid-phase synthesis instrumentation, for increased throughput and batch reproducibility.

Mots clés : molecularly imprinted polymer, plastic antibodies, epitope recognition, solid phase synthesis, nanomips

Participants :
- University of Porto (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 147815.04 €
Projet LangMix (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The present project aims to investigate the encounter between the Latin and the native vernacular written culture in medieval Scandinavia, through phenomena of language and script switching in epigraphic sources. The spread of Latin is a pivotal point in the development of all European literate societies. Scandinavia represents a unique case study where Latin and the Roman script encountered and mixed itself with an 800 year old native tradition based on the local vernacular and the runic script. From being monolingual and monoscriptal, Scandinavia became multilingual and multiscriptal. Through an interdisciplinary framework to be developed in synergy with leading scholars at the University of Oslo, epigraphic methods completed by multimodal and sociolinguistic analyses within a linguistic landscape perspective will serve to determine: 1) the medieval writers’ multilingual and multiscriptal proficiency; 2) the status relationship between the Latin and runic written tradition; and 3) the ideological presuppositions and purposes of the use of different languages and scripts. For the first time, these phenomena will be studied systematically and through an unexplored combination of historical material and modern sociolinguistic methods. This will not only yield new insights in the multilingual literacy of medieval Scandinavia and on its underlying cultural and ideological aspects, but also in its significance in a European context. By embedding the Scandinavian case in the process of cultural and political formation of Europe, this project will also contribute to understand the common cultural heritage in modern European societies.

Mots clés : epigraphy, philology, multilingualism, linguistic landscapes, multimodality, runology

Participants :
- University of Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €
Projet D-FINED (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

The present project is positioned in the research area of logic and semantics of computation, combining a rich mathematical theory with concrete applications in computer science. Finite model theory (FMT) is the specialisation of model theory to the class of finite models, and has been called ``the logic of computer science'' because in the latter field the basic models of computation are finite. Most of the classical results of model theory fail when restricted to finite models, hence FMT is studied using different tools and methods. For this reason, FMT has developed mostly independently from model theory and the research communities, as well as the techniques, are almost disjoint. FMT exemplifies a strand in the field of logic in computer science focussing on expressiveness and complexity (``Power"), as opposed to the one focussing on semantics and compositionality (``Structure"). In this project we will apply Stone duality to bridge the gap between the semantics methods of model theory, and the combinatorial and complexity-theoretic methods of FMT, i.e., to relate Structure and Power. In his Ph.D. thesis, the applicant has successfully applied Stone duality and topology to the study of formal languages and logic on finite words. The proposed project constitutes both a natural continuation of this research line, generalising from finite words to finite models, and a novel approach to FMT. The applicant will collaborate with the supervisor, who is a leading expert in the interactions between logic and computational models arising in computer science. An essential feature of this project is its high degree of interdisciplinarity, aiming to strengthen the connections between mathematics and computer science. The host institution, which is home to several experts in logic and foundations of computer science, will benefit from the applicant's experience in duality theory and topology, thus fostering cross-fertilisation within the European research community.

Mots clés : stone duality, finite and algorithmic model theory

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet MappingSpatialVision (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The present research aims to further our understanding of the mechanisms by which our brain makes sense of the visual world. Our brain cannot represent with full fidelity the overwhelming amount of information it constantly faces. Yet, understanding our visual world seems effortless. One strategy developed by the brain is to trade off poor spatial representations in the periphery for high-resolution foveal vision. Spatial attention is another strategy the brain relies on to select and prioritize visual processing at relevant areas of the visual field without having to move our eyes. Perceptually, attention benefits performance in many visual tasks, in line with heightened spatial resolution at the attended area. Physiologically, single-neuron recordings in animals have shown that attention alters the receptive-field (RF) properties of neurons, which may account for changes in human perception. Yet, human behavior depends on large-scale neuronal population codes. Thus, understanding how attention helps us represent information across the visual field requires to link human perception with changes in human neuronal populations. Here, I will do exactly that by combining a powerful behavioral approach I developed with recent neuroimaging techniques that can assess human neuronal population RF properties. Using cutting-edge, ultra-high resolution neuroimaging methods, I will pinpoint the neural mechanisms by which attention alters spatial representations at unprecedented levels of cortical organization in the human brain, further establishing the host’s recognition as a world-leading brain research center. This interdisciplinary training will reinforce my previous research skills and provide me with state-of-the-art neuroimaging expertise. The MSCA fellowship is a unique chance to expand my skills and reintegrate the European research community, putting me on the right track to pursue an independent career with a multifaceted profile of psychologist and neuroscientist.

Mots clés : spatial perception, spatial attention, population receptive field, 7 tesla mri, neuroimaging, reverse correlation, spatial integration, visual processing, neural mechanism, visual cortex

Participants :
- Royal Netherlands Academy of Arts and Sciences (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 177598.8 €
Projet POMOC (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The present study aims to investigate from a new perspective the collecting activities of Charles IV, king of Bohemia (1347-70), king of Romans (1346-78), and Holy Roman Emperor (1355-70). It proposes to go beyond narratives based on the nation-state and western-oriented research concepts, thereby renovating historical and artistic connections that national historiographies have obfuscated. In doing so, it will frame the topic trans-nationally. Rather than writing a large-scale synthesis based mainly on secondary sources, this research objective will be achieved by using a micro-historical approach focusing on a specific group of reused objects that are associated with Charles IV. At the centre of the project are Charles IV and the precious objects of diverse provenance which he acquired, assembled and commissioned to be adjusted. Being removed from the cultural context for which they were originally made and which determined their social values, the objects underwent, in different social and cultural contexts, transformation and subsequently integration with the new audience. They created multiple connections with the past and contributed significantly to the construction of the imperial self-image of Charles IV who was not only one of the most capable and effective rulers whom Europe had ever seen but also one of the greatest 'collectors' since the period of Classical antiquity.

Mots clés : charles iv  1316 78, collecting, composite objects, treasuries, cultural interactions, art history, microhistory, cultural studies, european cultural heritage

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 146591.1 €
Projet ColoFILM (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The prevalence and occurrence of inflammatory bowel diseases have experienced steep increase in Western countries, as well as in populations considered ‘low risks’ before. Nevertheless, currently available therapies, including anti-tumor necrosis factor-α (TNF-α) therapy, have numerous limitations and are often associated with severe adverse effects. Therefore, the research project aims at safer and effective inflammatory bowel disease therapy by proposing development of a novel multifunctional polymeric film based platforms for oral delivery of anti-TNF-α. The drug delivery system comprises of a nanoformulation encapsulating anti-TNF-α which are then entrapped into a mucoadhesive polymeric film. These mucoadhesive polymeric films are composed of second generation highly efficient mucoadhesive S-protected thiolated polymer, which are then loaded inside pH responsive capsules for site-specific delivery. The proposed system would provide enhanced therapeutic outcome by minimizing side effect via reduction of the frequency of dosing and targeted delivery of anti-TNF-α at the site of action, which would be achieved by preventing the degradation of the encapsulated biologics, prolonging the gastrointestinal retention time of the drug delivery system, increasing drug accumulation at target site and minimizing the systemic absorption. Furthermore, additional unique benefits of the proposed systems such as the biocompatibility, biodegradability, sustained drug release at targeted site, mucus penetration of the nanoformulation, and use of accessible and patient friendly oral route, can widen its biomedical applicability and explore its use in clinics and pharmaceutical industries.

Mots clés : oral antibody delivery, biomaterials, nanosystems, anti tnf alpha, inflammatory bowel disease

Participants :
- Université Catholique de Louvain (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172800.0 €
Projet MIDPO (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The previous decade witnessed a wave of innovative approaches to democratic public ownership at the municipal scale. Rather than a paternalistic provider of services, such approaches – diverse in both form and application – variously recast the (local) state in a more facilitatory or partnership role, promoting participatory co-governance and/or co-ownership of resources and assets. This research aims to establish whether such innovations embody a new form of 'prefigurative state thinking' that is fundamentally reworking, and requires new theories of, the relationship between civil society and the state. The objectives of the research include: 1. To develop an evidence-led typology of municipalist innovations in democratic public ownership 2. To determine (if and) how innovations in public ownership contribute to a ‘feminisation’ and ‘democratisation’ of urban life 3. To provide theoretical understandings of the changing relationship between civil society and the state 4. To identify and elaborate upon evidence-led design principles for feminised and democratised public ownership 5. To return and disseminate results to stakeholders and policy-makers, and pursue policy orientated impact The project will utilise a qualitative comparative research approach across two phases. The first phase is a secondary analysis of the Transnational Institute's (TNI) 'International Database of De-privatised Public Services', with a focus on developing a) a propositional typology of democratic municipal innovations; and b) identifying exemplar cases for primary research. The second phase will include primary research of exemplar cases, including co-identified cases in the host city. The fellowship includes a 6-month secondment at TNI as an integral part of the research. The fellowship will deliver policy impact in-line with the European Commission’s 2019-2024 priority areas and the UN’s New Urban Agenda commitment to expanding ‘meaningful participation in decision-making'.

Mots clés : municipalisation, municipalism, hybrid ownership, democratic ownership, democratisation

Participants :
- Autonomous University of Barcelona (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet MACROPRU (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

The primary aim of the action is to investigate how new macroprudential policies can influence financial stability without contributing to inequality in society. In this project we aim to apply cutting-edge, agent-based simulation techniques to uncover the redistributive effects of macroprudential policies and to examine the combination optimality of the macroprudential tools from the social welfare perspective. The results of this project will complement the conclusions extracted from the ECB system-wide stress-testing exercises by providing data on the rise of inequality in EU countries due to the adoption of new financial regulations. It will also supplement the macroeconomic impact assessment for the Basel III reforms (cost-benefit "Growth-at-Risk" approach). This project expands our knowledge about a new, innovative tool, namely agent-based modeling, that can be used in financial oversight. It provides us with the practical knowledge of how to take into account the heterogeneity of the agents in the models and how to apply new Bayesian estimation techniques. The results of the project may guide policymakers and central bankers on how to reshape financial regulations and to calibrate macroprudential policies in order to minimize adverse social effects and to reduce inequality (by supporting a social policy). The project is consistent with the European Commission’s support on research programmes on the public sector and social innovation that is described in the Europe 2020 Flagship Initiative Innovation Union. The researcher will be fully integrated into Prof. J. Doyne Farmer’s team at the INET Oxford and at the Mathematical Institute of the University of Oxford. The Curie IF will give the applicant the opportunity to perform relevant and state-of-the-art research in the best institute of complexity economics in the world, to re-enforce her position as an independent research group leader and to initiate new long-term collaborations.

Mots clés : central banking, financial stability, macroprudential policies, agent based modeling, simulation models with heterogeneous agents, redistributive effects, social welfare, inequality, stress testing

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet OceanIS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The primary goal OceanIS is to constrain the contribution of changes in Southern Ocean circulation to the recent acceleration in Antarctic Ice Sheet mass loss. Improving our knowledge of ice shelf–ocean interactions is a critical step toward reducing uncertainty in future sea level rise projections. Ice shelves are coastal areas of floating ice that extend from an ice sheet out over the ocean, and their destabilization can trigger rapid ice discharge. It is now evident that ocean–driven basal melt is the major cause of ice loss from Antarctica’s fringing ice shelves. However much of the fundamental dynamics of how the ocean delivers heat to the ice shelves remains unresolved. Progress in this area requires bringing together the fields of ice shelf–ocean interactions and large–scale Southern Ocean oceanography. The Southern Ocean overturning entails the upwelling of Circumpolar Deep Water (CDW) offshore Antarctica. The Antarctic Circumpolar Current has shifted poleward, the impact of which, e.g. over the upwelling of CDW, remains unknown. Since CDW is linked to the highest ice shelf thinning rates yet observed, the variability of the CDW properties and its interaction with the ice shelves is the focus of this proposal. To do this, OceanIS integrates, for the first time, several unique data sets, which extend from the deep ocean to the sub–ice shelf environment. These include data from the Argo network, instrumented seals, and measurements from the only decadal–scale record of ocean properties beneath an Antarctic ice shelf, the Amery ice shelf. OceanIS will help to test which of the suite of current climate models shows ice–ocean interaction processes and CDW variability that are most in line with reality. Given that the forcings driving Southern Ocean changes are expected to continue in the future, results of OceanIS will be a major step toward reducing the uncertainty that surrounds the future stability of the Antarctic Ice Sheet and sea level rise projections.

Mots clés : southern ocean, cryosphere, antarctic ice shelves, circumpolar deep water, sea level rise

Participants :
- University of Southampton (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €