Projet CaSR Biomedicine (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2+ ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling. The objectives of CaSR Biomedicine are: 1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective. 2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general; 3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders. 4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area. Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).

Mots clés : calcium, g protein coupled receptor, signalling bias, calcimimetics, calcilytics, pathophysiology

Participants :
- FH JOANNEUM University of Applied Sciences (Autriche) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Aliri France (France) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Vrije Universiteit Amsterdam (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255374.28 €
- University of Oxford (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- Cardiff University (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- Medical University of Vienna (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 511868.16 €
- Tissuegnostics gmbh (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 255934.08 €
- S.a.f.an. bioinformatics - sas di pugliese luisa (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 258061.32 €
- Aht-management (Hongrie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Picardie Jules-Verne (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262875.6 €
- University of Florence (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- Amgen gmbh (Autriche) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Novartis (Switzerland) (Suisse) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- BioTalentum (Hungary) (Hongrie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 223913.52 €
- University of Copenhagen (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 290081.88 €
- Hospital Sant Joan de Déu Barcelona (Espagne) — Partner, beneficiary, Recherche, subvention : 247872.96 €
- University of Manchester (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- University of Liverpool (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €