Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet PATCH (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Water pollution has become a critical global challenge with serious environmental and health consequences, driven by rapid industrialization, poor waste management, and ineffective sewage systems. Addressing this critical issue requires innovative and efficient water treatment technologies. Among such technologies, photoelectrocatalysis (PEC) combines photocatalysis and electrocatalysis, showing great promise for pollutant degradation. While PEC has primarily been explored for hydrogen production, its application in water decontamination is increasingly important, highlighting the need for advanced materials to enhance PEC performance. BiVO4, a well-studied n-type semiconductor, offers potential for PEC due to its narrow band gap and low cost. However, its performance is limited by poor charge separation and high recombination rates. To overcome these challenges, this project focuses on developing a CuO/BiVO4 heterojunction, which improves charge separation through the creation of a p-n junction, leading to enhanced photocatalytic performance. The inclusion of plasmonic nanoparticles, especially gold (Au), will further improve PEC activity by increasing light absorption, boosting charge transfer, and facilitating more efficient redox reactions, resulting in effective pollutant degradation. Synthesis challenges, such as scalability and purity, will be tackled using pulsed laser ablation in liquid (PLAL), an environment-friendly and efficient technique for fabricating nanomaterials. PLAL offers advantages in controlling nanoparticle size, ensuring strong interfacial contact, and producing high-quality materials. Through the development of a plasmonic nanoparticle-enhanced CuO/BiVO4 heterojunction for PEC pollutant degradation, this project aims to deliver a scalable, efficient, and environmentally sustainable solution for water purification, contributing to cleaner water and a healthier planet.

Mots clés : photoelectrocatalysis, pulsed laser ablation in liquid, pollutant degradation

Participants :
- Lyon-I université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 242260.56 €
Projet SHAPECHANGE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Bioactive macrocyclic compounds are valuable platforms in drug discovery. More often than not, natural products represent attractive leads, the structures of which may be altered by chemical synthesis to enhance efficacy, lower toxicity, and superior physicochemical properties. The proposed project aims to a practical and programmable strategy for precise skeletal editing of large ring structures by aligning catalytic ring-opening metathesis, site- and/or stereoselective modification of the linear intermediates, and formation re-formation of the macrocycle through catalytic ring-closing metathesis. The advance will significantly enhance our ability to navigate hitherto unexplored chemical space, needed for drugs discovery. The proposed investigations are centered on epothilone C, an important naturally occurring compound. We will to demonstrate the versatility of our approach by precise framework editing of this anticancer agent in a systematic way. The first phase will entail Z-to-E isomerization of the macrocyclic alkene, an alteration that will significantly change the molecule’s three-dimensional shape. This will be followed by site specific insertion of a methylene or a hydroxy methylene at one or both sides of the acyclic allylic sites. We will then re-close the ring. Similarly, ring contraction will be implemented through deletion of one or two methylene groups. Finally, ring expansion and ring contraction will be combined to achieve ring distortion.

Mots clés : framework editing, macrocyclic natural products, epothilone c, olefin metathesis, ethenolysis, enantioselective allylic substitution, olefin isomerization, drug discovery

Participants :
- Université de Strasbourg (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet METEDIT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Catalytic olefin metathesis is a transformative transformation with many unique attributes, one being the possibility of converting a ring to a modifiable acyclic diene by ring-opening cross-metathesis (ROCM). However, the existing methods are rare and limited to those that generate E-enoates. To the best of our knowledge, there are no available methods for ROCM reactions that can be used to access Z-alkenes from reactions involving five- to eight-membered rings. To address this, we will develop a ROCM method for converting the small rings to readily alterable acyclic dienes efficiently and in high Z:E ratios. On the basis of preliminary (unpublished) results, a set of molybdenum alkylidene complexes recently designed by the host group will be utilized. We will investigate and develop a method for ROCM of cyclohexene with several commercially available Z- and E-alkenyl halides. The strategy will then be extended to five-, seven- and eight-membered ring alkenes. The diene products can be used for rapid synthesis of bioactive compounds, such as antitumor tetrahydrosiphonodiol, and their specifically altered analogs. Another notable aspect of the project will be application to precise skeletal alterations of polycyclic bioactive compounds. We will exploit the presence of an olefin within a bioactive compound as the launching point for brief sequences leading to various specific modifications. This will obviate the need for lengthy and tedious de novo synthesis of each analog. More specifically, we will develop the “open ring → modify → close ring” (OMC) strategy, and by using it prepare an assortment of specifically modified analogs of androstadiene and vindoline. Through collaboration with experts, these compounds will be tested for in vitro bioactivity. Catalyst and method development will thus be applied to accessing formerly uncharted chemical space, which is central to new lead discovery and drug development.

Mots clés : framework editing, polycyclic natural products, olefin metathesis, alkenyl halides, cross coupling, ethenolysis, drug discovery

Participants :
- Université de Strasbourg (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet RENOIR (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The electron-phonon interaction is ubiquitous in many-particle physics and chemistry. The strength of the electron-phonon coupling (EPC) determines countless physical properties and phenomena. Notably, it gives rise to conventional superconductivity and plays a key role in high-temperature superconductivity. The main goal of RENOIR is to accurately determine the EPC strength in materials that are relevant for technological applications, providing crucial insights into the behaviour of excitons and phonon-driven phenomena. Resonant inelastic x-ray scattering (RIXS) spectroscopy holds the promise to access phonon excitations with a remarkable high-resolution, thanks to the significant technical advancements achieved in recent years, providing momentum dependence and bulk sensitivity. However, the interpretation of measured signatures remains challenging since different excitations are coupled through interactions. Indeed, although RIXS is used to measure EPC, it primarily reveals exciton-phonon coupling, due to the interaction with a core hole. So far, theoretical approaches mainly rely on oversimplified models that use adjustable parameters to fit experimental results, limiting their applicability. RENOIR aims to convert this challenge into the opportunity to realise the great potential of RIXS to determine EPC in quantum materials. RENOIR will develop a novel parameter-free methodology to calculate RIXS spectra, combining accurate and reliable approaches, such as the Bethe-Salpeter Equation within Green’s functions theory for excitons, and Density Functional Perturbation Theory for phonons. As a primary application, RENOIR will focus on high-temperature superconducting materials and heterostructures, celebrated for their transformative power in electronics and energy applications. Moreover, the resulting software will be made freely available to a very wide community, opening the way for understanding and predicting RIXS measurements of EPC in many other materials.

Mots clés : theoretical spectroscopy, resonant inelastic x ray scattering, density functional theory, green s functions, bethe salpeter

Participants :
- Université de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet HEW-SMEFT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The lack of conclusive experimental evidence for new physics (NP) underscores the need for a comprehensive strategy beyond the Standard Model (SM). Current experimental results suggest that NP could be heavy and, therefore, beyond the direct reach of current colliders. This possibility makes Effective Field Theories (EFTs) an invaluable tool for NP searches, allowing us to exhaustively exploit information from diverse measurements, observables, and experiments across different energy scales. One such EFT, widely used in the search for physics beyond the SM, is the Standard Model Effective Field Theory (SMEFT). The sensitivity to NP hinges on the accuracy of SMEFT predictions, as the effectiveness of SMEFT lies in establishing correlations among potential deviations in SM interactions. The more precise these predictions are, the greater the sensitivity to NP effects, leading to more stringent constraints from SMEFT global studies. Sudakov electroweak (EW) logarithms represent the leading higher-order perturbative EW corrections at high energies—a regime where EFT effects are expected to dominate. This project leverages this feature, aiming first to compute the one-loop Sudakov EW corrections for diboson production in SMEFT. The second goal is to perform a complete one-loop EW computation for vector boson pair production in SMEFT, capturing EW corrections beyond the logarithmic ones, given the process's critical importance for EFT studies. Given the current state of the art in both SM and SMEFT predictions, this project is poised to push the frontier of theoretical predictions for LHC studies. The project is structured into three work packages, encompassing the analytical calculations, their implementation into a flexible Monte Carlo framework, and the dissemination of results through peer-reviewed publications and presentations at international and local conferences.

Mots clés : effective field theories, higher order calculations, electroweak theory, collider phenomenology

Participants :
- Université de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet VIOLENDINGS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The purpose of this project is to study the complex integration of violence in the Spanish Golden Age happy ending narrative. In the ‘idealistic’ Spanish narrative genres of the second half of the 16th and the first half of the 17th century, such as the pastoral and the courtly novel, the inclusion of violence is problematic. It is useful to create a gripping plot, but must be ‘solved’ to reach a happy ending. The project will propose the concept of ‘economy of violence’ to study the narrative structure of these genres and will analyze the strategies to deactivate and legitimize violence that allow these plots to resolve into a happy ending.  Beyond the literary approach, the project has the ambition to propose a multidisciplinary understanding of these strategies, bringing together literature, historical sociology and gender studies. Considering the social structures of the Golden Age Spain, together with the concrete context of production and consumption of these genres (almost always written by men and widely consumed by women), the project intends to provide a critical analysis of what was presented as a happy ending and an ideal solution to violence -particularly to gender-based violence- through these plots. This panorama will be completed with a separate study of the courtly novels written by women and an analysis of how the narrative schemes produced by the male hegemonic culture and the traditional happy endings were transformed or even rejected in their narrative production.  The project has two main objectives. On one hand, from a literary perspective, it aims to arrive at a better understanding of the ‘idealistic’ narrative genres of the Spanish Golden Age through the concept of ‘economy of violence’. On the other hand, from a socio-historical and a gender perspective, it aims to analyze the interplay between the dictates of the Spanish patriarchal society of the 16th-17th centuries and the structure of the idealistic narrative of this period.

Mots clés : spanish golden age narrative, pastoral novel, courtly novel, happy endings, violence, violence against women

Participants :
- Université de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet MitoTransferImmunity (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Mitochondria are organelles (‘little organs’) of the cell that generate the majority of its energy and have been shown to play a key role in host immunity. Recent evidence has demonstrated that mitochondria within a cell are not fixed, but are capable of transferring from one cell to another through a process known as ‘mitochondrial transfer’. My project focus on the transfer of mitochondria from bone marrow stromal cells (BMSCs) to immune T cells. The objectives of the project are to explore the effect of BMSC mitochondrial transfer cells on (i) immune T cell functionality (in particular ROS production) and (ii) its role in adaptive immune cell responses. The MSCA fellowship and tailored training program will help me towards my career goal of establishing my own junior research group by increasing my academic track record, helping me gain critical supervisory/teaching experience, and expand my technical/transferrable skill sets.

Mots clés : mitochondria, t cells

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet BTChron (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

BTChron aims to advance chronological methods in archaeology by developing innovative Bayesian approaches to the analysis of typo-chronologically dated datasets, where temporal attributes are typically reported as time spans. Failure to formally integrate these time spans into statistical analyses can potentially lead to biases in interpretation. The proposed research addresses the critical limitations of current methods, which are inadequate for dealing with chronological uncertainty.  Applicable to any temporal analysis of large archaeological datasets, the proposal will make a substantial contribution to the field of quantitative archaeology by providing robust statistical tools for chronological analysis, ensuring the integration of legacy data into new, scientifically rigorous frameworks. The proposal is interdisciplinary, combining data science approaches with archaeological/historical methods and zooarchaeology. BTChron will select open access datasets to model temporal changes in three metrics commonly used in zooarchaeological analysis: LSI (Log-Size-Index), NISP (Number of Identified Specimens) and age-at-death. By focusing on faunal assemblages from Western Europe during the Roman period, BTChron will also provide a more accurate understanding of agricultural changes driven by Romanisation. The results will improve archaeological interpretations and contribute to open science through reproducible methods and accessible data.  The proposed research will be conducted at the McDonald Institute for Archaeological Research in Cambridge under the supervision of Dr Enrico Crema, a leading expert in applications of Bayesian approaches to archaeological data problems.  This fellowship will allow the Researcher to develop their expertise in data science approaches, which is essential for their future ambitions in the field of quantitative archaeology.

Mots clés : quantitative archaeology bayesian methods chronological modelling gallia narbonensis roman italy roman britain western europe roman agriculture

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet CP-PeLED (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

This project aims to realise high-efficiency circularly polarized perovskite light-emitting diodes (CP-PeLEDs) by developing chiral perovskite emitters with efficient chirality transfer. The proposed approach involves the design of chiral perovskite emitters using anionic chiral ligands for direct and efficient chirality transfer and advanced circularly polarized spectroscopic techniques to unveil the fundamental mechanisms behind chiral transfer and emission process. The outcome will be the realization of the first CP-PeLEDs that simultaneously achieve high emission efficiency and strong chiroptical activity, paving the way for next-generation applications such as three-dimensional displays, quantum information processing, and spintronic devices.

Mots clés : materials science, engineering, light emitting diode, chirality, circularly polarized light, metal halide perovskite, photonics, three dimensional display, quantum information, spintronics

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet NanoProt4Cond (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Biomolecular condensates, formed by liquid-liquid phase separation (LLPS), play a pivotal role in diverse biological processes and diseases, including cancer. Despite their importance, it is still a challenge to understand the role of condensates in biological regulation. "NanoProt4Cond" aims at exploring the Wnt signalling pathway, deregulated in cancers like colorectal cancer, using the cutting-edge high-throughput technology ‘PhaseScan’ to investigate condensate formation by Wnt-related proteins. After identifying the proteins driving condensate formation, the project will engineer consensus-designed tandem repeat proteins (RPs) as condensate modulators (c-mods) by grafting short linear peptide motifs (SLiMs) from Wnt-pathway proteins onto RPs, creating multi-valent and multi-functional c-mods. While nanoparticles have been widely studied for overcoming traditional therapy limitations, their interaction with biomolecular condensates remains unexplored. "NanoProt4Cond" will fuse the most promising c-mods with proteins that self-assemble into nanoparticles, creating engineered protein nanoparticles that offer precise control over multifunctionality and valency. The c-mod protein nanoparticles (c-NPs) will be tuned to target and modulate condensates, unlocking novel therapeutic strategies for cancer treatment. This project will deepen the understanding of condensate formation within the Wnt pathway and contribute to novel cancer therapeutics. Hosted at the University of Cambridge, this MSCA PF will provide advanced technical training in protein design, molecular therapies, and biomolecular condensates, allowing the researcher to apply her expertise in nanomaterials and biomedicine while expanding her skills in supervision, project management, and proposal writing.

Mots clés : biomolecular condensates protein nanoparticles c mods protein engineering nanomaterials cancer therapy protein therapeutics

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet MEASURE-CO2RR (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Surging energy needs and fossil fuel reliance have triggered a concerning rise in CO2 emissions, raising the frequency of devastating climate-related disasters. Despite expanding renewable energy sources like solar and wind, their intermittent nature has spurred demand for better storage technologies due to the limitations of current batteries. Heavy industries and transport sectors still rely on fossil-based fuels. Although H2 appears as an alternative, challenges remain regarding its transport. Electrocatalytic CO2 reduction (eCO2R) emerges as a solution, turning CO2 into valuable chemicals and fuels (compatible with existing industrial frameworks) using green electricity. Metal-based heterogeneous eCO2R catalysts exhibit notable stability but they face product selectivity issues, requiring energy-intensive downstream separation methods. Inspired by the active site of [NiFe]-CODH enzyme which efficiently converts CO2 to CO, many 2nd-sphere-modified molecular complexes (MCs) have been developed, showing elevated selectivity, efficiency, and stability. But most of them function within organic media, limiting their integration into devices. Moreover, synthesizing these 2nd sphere-modified MCs is highly resource-intensive. MEASURE-CO2RR aspires to mimic the enzymatic active site on heterogeneous electrodes. This is achieved by encapsulating MCs within commercially available polymers, introducing both the 2nd-sphere (stabilizing intermediates) and tertiary-sphere effects (precise H+ delivery). Aiming to achieve high selectivity, catalytic current, and stability within an aqueous medium, MEASURE-CO2RR stands out by encompassing the development of hybrid catalytic systems, thorough mechanistic studies utilizing in-situ spectroscopic techniques, and eventual integration of these hybrid systems into CO2-electrolyzers. This marks a significant stride towards the essential industrial implementation of eCO2R, effectively aligning with the objectives of the EU Green Deal.

Mots clés : electrocatalytic co2 reduction, heterogeneous electrocatalysis, in situ spectroscopy, intermediates, hybrid materials, renewable chemicals fuels, tandem systems, co2 electrolyzer, waste reforming

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €