Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SAFARI (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Simulating African Agro-Pastoralist Routes and Interactions (SAFARI, the Swahili word for journey) uses computational modelling, satellite remote sensing, statistical analyses and targeted archaeological field surveys to investigate overland pastoralist mobility corridors in a broad region across eastern Africa. Through a state-of-the art interdisciplinary methodology, it evaluates relationships between pastoralist mobility corridors, the emergence of coastal Swahili urbanism, and the expansion of caravan trading during the Middle-Late Iron Age (MIA-LIA, eighth-nineteenth centuries CE). Results from this study will inform an understanding of the emergence of early globalization in this part of the world. Though pastoralist presence has been hypothesized at early coastal Swahili urban centres, it remains unclear to what extent MIA-LIA pastoralist mobility between inland regions and the coast impacted spatiotemporal developments in Swahili urbanism and the emergence of caravan trade routes. Pastoralist interaction routes would have been conditioned by the ecological considerations of cattle herders, who relied on access to water and grasslands. Comparing modelled mobility pathways to spatial databases of coastal and inland settlement and maps of caravan routes in the nineteenth century, SAFARI will explore whether pastoralist mobility was a significant factor in shaping early connections between eastern Africa and the Indian Ocean. Satellite remote sensing and targeted field surveys will be used to test and refine models, and narrow down the affordances and limitations structuring the spatial organization of mobility corridors. Training and analysis will occur at the McDonald Institute for Archaeology at Cambridge University, primarily within the Computational and Digital Archaeology Lab.

Mots clés : cost surfaces, remote sensing, modelling, eastern africa, pastoralism, swahili

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet ProPPS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The 1322 consultation launched by Pope John XXII on the theological doctrine of Apostolic Poverty is one of the most catalyst moments in European intellectual history, where a question of religious practice evolved and exploded into a question of property, power, and the political state. The MSCA-PF ProPPS is an interdisciplinary project that brings together theological doctrine, religious and political identities, and royal and papal politics within the canvass of the medieval intellectual, spiritual, and political life of the Angevin state and theologians. ProPPS will be the first attempt to map and analyse a collection of texts connected to the patronage of King Robert of Naples, to study the group Angevin theologians as part of an intellectual network within the poverty debate, and to situate the intellectual position of King Robert in his sacral-political symbiosis with the papacy. The project will shift current scholarly focus from the papal-imperial conflict to highlight the intellectual richness and diversity of the theological and philosophical treatises within a complex network of political and religious loyalties. ProPPS has three research objectives: (1) a doctrinal, philosophical, and philological study of a major treatise in the poverty debate by the trusted papal adviser Francis of Meyronnes, of his thoughts on property, social and economic power, and the nature of civil and political state, before proceeding to (2) a prosopographical and doctrinal study of the Angevin theologians and their contributions to the poverty controversy in 1322, on where they stand individually and collectively on the controversy, and finally (3) a macroscopic study of the court of Robert of Naples in its relationship with the Franciscans, the ecclesiastical hierarchy, and the papacy. The project will adopt methods of manuscript studies, conceptual and contextual analysis of selected texts, and document and archive analysis.

Mots clés : poverty, franciscan, papacy, theology, philosophy, political thought, intellectual history, angevin, naples

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet EISNMR (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Na-ion battery (NIB) is the most promising technology among the next generation battery technologies. The main issue facing NIB is in their low cycle life. Limited cycle life of Na batteries results from degradation mechanisms occurring at both the cathode and the anode. While multiple cathode materials have been developed, the best-performing anode material remains hard carbon. Despite hard carbon's acceptable energy density, it suffers from inadequate cycle life. Significant efforts have been made to understand Na storage mechanisms in hard carbon. However, little effort has been devoted to understanding the degradation mechanisms and strategies to mitigate them. I propose research spanning multiple scales to evaluate the mechanisms causing degradation in hard carbon anodes and develop strategies to inhibit them, focusing on SEI and charge transfer mechanisms, and their influence by various operating parameters. This work will involve intensive mechanistic studies of Na-ion charge transfer and interfacial processes by conducting in-situ Electrochemical Impedance Spectroscopy (EIS) and Nuclear Magnetic Resonance Spectroscopy (NMR) measurements, which will identify and quantify the contributions of both Na-ion charge transfer and interface to hard carbon degradation. I will employ hard carbon symmetric cell configuration that allows for detailed analysis without the contribution from other electrodes. I will scale this mechanistic work with various parameters including electrolyte composition and temperature. The results will identify the primary contributors to the low cycle life of hard carbon anodes and bring strategies to extend their cycle life.

Mots clés : na ion storage, solid electrolyte interphase, electrochemical impedance spectroscopy, nuclear magnetic resonance spectroscopy, cycle life

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet MTB-DETOX (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) kills 1.5 million people every year. Major challenges facing TB eradication are the lack of effective and affordable treatments, the slow pace of innovation in TB drug discovery and the emergence of antibiotics resistance. Therefore, new approaches for addressing these challenges are urgently needed. Mtb is highly adapted to survive into human macrophages which expose the bacterium to many stresses including metal ion in-toxification, whereby the host cell increases its metal ion levels resulting in inflow of metal ions into Mtb. The host laboratory has previously demonstrated that the P-ATPase transporter CtpC is part of the metal efflux system involved in zinc detoxification, which is important for Mtb survival in macrophages. Intriguingly, CtpC and two other P-ATPases are encoded together with small proteins containing a domain of unknown function named DUF1490. Unpublished data show that the DUF1490 protein encoded with CtpC binds zinc and confers zinc in-toxification tolerance to Mtb. Additionally, DUF1490 proteins co-localize with CtpC to the plasma membrane into dynamic microdomains, named “metal efflux platforms”. I propose to uncover the function of DUF1490 proteins by testing two hypotheses: 1) DUF1490 proteins are metallochaperones that facilitate the intracellular transport of metal ions to membrane transporters, and 2) DUF1490 proteins are scaffold proteins involved in P-ATPase stabilization and metal efflux platforms assembly. To explore these hypotheses, I will combine genetic, microbiology and molecular biology strategies with high-resolution optical imaging, lipidomics and proteomics. Rigorous execution of the proposed research will generate insights into the role of DUF1490 proteins in Mtb metal detoxification and pathogenicity, as well as into the novel concept of metal efflux platforms, thus yielding opportunities for TB drug development that go beyond traditional targets.

Mots clés : tuberculosis, mycobacteria, metal efflux, functional membrane microdomains

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
- Université de Toulouse (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Bordeaux (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet 6G-AI-TANGO (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

To fully exploit the 6G potential and ensure near-zero latency, infinite capacity, and 100% reliability and availability communications, Mobile Network Operators (MNOs) are expected to deploy Zero-touch Network and Service Management (ZSM) solutions that completely automate the resource orchestration and work at a very fast timescale, and Artificial Intelligence (AI) is regarded as the primary enabler for proactive decision-making algorithms that will underpin ZSM. However, the robustness and trustworthiness of AI predictors are critical aspects and represent one of the major barriers presently withholding MNOs from trusting ZSM technologies. In fact, all existing studies on mobile traffic forecasting work under assumption of stationary network, but, in the case of mobile network Key Performance Indicators (KPIs) prediction, user demands and network configurations are time-varying (non-stationary) in operational mobile networks. For example, update of antenna configurations or shifts in popularity of mobile applications can happen over time. Thus, this project is termed "practical AI for Time-vAryiNG network traffic fOrecasting in 6G" (6G-AI-TANGO) and aims to: (i) assess and quantify the severity of temporal changes (due to non-stationarity) in 6G network KPI forecasting, (ii) design AI models tailored to mobile KPI forecasting that are resilient to the long-timescale temporal variations regularly encountered in real-world user demands and network configurations, and (iii) verify the robustness of proposed predictors on real-word data and in production-grade 6G mobile network during non-academic placement at Telefónica.

Mots clés : mobile traffic, traffic forecasting, drift detection

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 242593.2 €
- Telefónica (Spain) (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet NanoHeadTail (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The NanoHeadTail proposes a novel and original approach combining fluorescence microscopy and nanotechnology to resolve the morphological and rheological properties of the brain extracellular space (ECS) at the nanoscale. Current methods allow to determine the local dimensions and fluidity of the ECS, but they do not allow to resolve its structural complexity and are limited to an analysis in 2D. This project proposes the simultaneous monitoring of the position, the translational and rotational diffusion of fluorescent probes over time and in 3D, allowing to determine the volumetric structure, fluidity and inner organization of the ECS locally. For that, a novel type of asymmetric probes will be designed based on the localized functionalization of single-walled carbon nanotubes with fluorescent color centers at their ends, analyzed using a custom cutting-edge fluorescence microscope and tested in live brain tissues from mice models of the Parkinson’s disease. The applicant will bring his strong expertise in the photophysics and chemistry of carbon nanotubes, critical for the preparation of the probes. In parallel, the fellow will gain a high-level hands-on training on optics assembly, super resolution microscopy and single particle tracking, imaging analysis and neurosciences. The project will be performed at the IOGS-LP2N (CNRS/Univ. Bordeaux), a leading French research institution, under the supervision of Dr. Laurent Cognet expert in the single particle tracking of nanoobjects. The proposal contains well-identified work packages which will ensure efficient science development but also project management, career development, training, technology transfer and communication. The fellow’s expertise, the hosting lab, the infrastructure, facilities and the mentoring will guarantee the successful execution of the NanoHeadTail goals and will allow the applicant to reach a high level of professional maturity and to develop his career as an independent researcher.

Mots clés : single particle tracking, single walled carbon nanotubes, neurophotonics, fluorescence microscopy, super resolution microscopy, near infrared fluorescence, brain extracellular space

Participants :
- Institut d'optique Graduate School (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Bordeaux (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet TsarsFAMINE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The turn of the nineteenth and twentieth century witnessed transformational changes in the Russian economy, marked by rapid integration into global markets and state-led industrialization. In the same period, Russian society faced dramatic crises, the most devastating of which were a series of famines that cost millions of lives. Both dimensions of development have been subject to extensive study, but the fundamental disconnect between these historiographies leaves a yawning knowledge gap. TsarsFAMINE will conduct a systematic examination of famine intensity and famine relief strategies in regions of the Russian Empire between 1891 and 1911, constructing the first comprehensive database of demographic and agricultural statistics at the county level. Using this novel and unique database, a multi-variate analysis will identify the causes of famine including the potentially significant role of trade policy. The project will then combine quantitative and qualitative sources and analytical methods to examine the effectiveness of different famine-relief strategies adopted in different provinces of Russia over the twenty-year period. TsarsFAMINE advance the state-of-the-art in several ways. It will improve our understanding of the deeper socio-economic outcomes of the state policies that propelled the industrialization of late imperial Russia. It will contribute to the broader literature on the effectiveness of famine relief exploiting a richly documented historical case study with significant variation in famine intensity and famine relief policies. The project promises important insights for development experts and international institutions that engage in the study of modern famines and engage in global famine relief. TsarsFAMINE will be a major accelerator in the career of the researcher, who will benefit from relevant expertise and training opportunities at the host institutions, expand her international network, and advance her research agenda.

Mots clés : tsarist russia, trade policy, famine, famine relief

Participants :
- Université Bocconi (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet ACryL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

As organizations increasingly rely on cloud services and shared infrastructures to store data and delegate resource-intensive computations, it is essential for maintaining privacy, security, and compliance with regulations to i) protect data while ensuring that only authorized individuals or systems can decrypt and use it, and ii) guarantee the correctness of the computation performed by cloud services. Advanced cryptographic primitives tackle both of these challenges: on the one hand, attribute-based encryption (ABE) effectively addresses the problem of selective data sharing while preserving confidentiality of unauthorized messages, on the other hand, succinct arguments (SNARKs) enable end users to verify efficiently that outsourced computation was performed correctly by cloud providers.  In recent years, both ABE and SNARKs have seen tremendous research progress, especially in the context of lattice-based cryptography, where both constructions often rely on shared techniques, underscoring the deep synergy between these two cryptographic primitives.  Leveraging lattice-based assumption offers several key advantages in this context, which are essential to the proposed project, in particular, enabling the construction of ABE for general circuits, and providing post-quantum security, meaning these constructions are believed to remain secure even in the presence of quantum computers.  By exploring and developing new techniques that leverage these synergies, this project aims to advance theory and practice in both domains and construct robust, quantum-secure cryptographic systems that address the complex security and privacy challenges of the digital age.

Mots clés : cryptography, advanced encryption, proof systems, post quantum, lattice based cryptography

Participants :
- Université Bocconi (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet AURORA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

This multidisciplinary AURORA project focuses on the development of prototype rotaxane (molecular ring-on-thread) structures displaying triplet fusion upconversion photoprocess. Structural design will instill this process via spontaneous excited dye collisions in confined trajectories of the designed interlocked molecules to create a fluorescent state (from two combined low energy photons). Such architectures will help to collect information on molecular photon upconversion and intramolecular diffusion processes through time-resolved spectroscopies. Moreover, it will produce intermittent fluorescence “blinking” by which detailed analysis will afford a new methodology for super-resolution imaging, namely below the diffraction limit of light. In theory this can provide solutions to some limitations of actual approaches and impact this research field. Fluorescence modulation within these autonomous [2]rotaxanes by triplet fusion will lead to studies down to the single-molecule level (based on Stochastic Optical Reconstruction Microscopy) which will be employed to establish a new localization microscopy method (“T2-STORM) and be validated through imaging commercial nanostructured biomacromolecules. Both leading French research institutes, Institut des Sciences Moleculaires (ISM) and Laboratoire Photonique Numerique et Nanosciences (LP2N) will co-host the AURORA project. The French fellow, specialist in synthetic organic and supramolecular chemistry, will be taught molecular photophysics/photochemistry and super-resolution fluorescence imaging. Additional work packages will guarantee efficient scientific advances, training, career development, management, communication and potentially technology transfer. Association of the fellow and research groups skills at the chemistry-photophysics-imaging interface, available infrastructure and equipment, will participate to both the fellow’s future independent research career and achieving ambitious AURORA objectives.

Mots clés : molecular machines photoactive rotaxanes fluorescence triplet fusion upconversion super resolution microscopy

Participants :
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Bordeaux (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet INTIGT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Glioblastoma (GBM) is the most common malignant primary brain tumour in adults. The current standard of care is surgical resection of GBM tumours followed by chemotherapy and ionizing radiation (IR). Despite these intense efforts, GBM tumours remain incurable and the median survival rate of GBM patients remains only ~15 months. This dismal clinical outcome underscores the urgent need for novel therapeutic strategies for GBM. At the cellular level, GBM tumours contain a rare population of self-renewing, highly invasive stem cells termed brain tumour stem cells (BTSCs) that are endowed with properties to proliferate, spur the growth of new tumours, and at the same time, evade IR and chemotherapy. Thus eradicating BTSCs in tumour bulk represents a promising approach to fight brain cancer at its root. However, there are presently no treatments targeting BTSCs in GBM. Recent preliminary data obtained by the applicant at McGill University (Montreal, Canada) led to the hypothesis that a novel signalling pathway, galectin1/HOXA5, controls BTSC behaviour and represents a promising target to eradicate BTSCs. Thus, the applicant will join the “Laboratoire de l’Angiogenèse et du Microenvironnement des Cancers” at University of Bordeaux to test this hypothesis, under the supervision of Pr. Bikfalvi. The host, the supervisor and the candidate represents the perfect match to realise this proposal and the project is designed to bring forth a two-transfer of knowledge between the host and the candidate. The advanced techniques and transferable skills that the candidate acquires through this research will largely broaden his competencies and increase his employability as an independent researcher in the field of neuro-oncology. Results generated through this proposal will be innovative and of clinical relevance for GBM patients. This study has the potential to open new therapeutic avenues and pave the way for future clinical trials for better treatment of these deadly tumours.

Mots clés : glioblastoma brain tumour stem cells carbohydrate binding proteins cancer chemotherapy radiotherapy pateint derived xenografts

Participants :
- Université de Bordeaux (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €