Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CARMESilk (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

This research project, CARMESilk, aims to develop an innovative solution for preventing chemotherapy-induced alopecia (CIA) to improve cancer patients' quality of life. CIA is one of the most distressing side effects of cancer, affecting up to 65% of cancer patients undergoing treatment, causing social withdrawal, decreased self-esteem, and depression. Doxorubicin, a chemotherapeutic agent from the group of anthracyclines, is used as cancer drug in breast, ovary, bladder, and thyroid cancers, among others, and it has an incidence of CIA of 60-100%. Current therapies focus mainly on scalp cooling technology with limited availability, high cost, long-time treatment, and not recommended for children. For this reason, the development of effective CIA prevention technologies has the potential to be truly life-changing for cancer patients by alleviating the psychological distress associated with treatment and by empowering patients to maintain a sense of normalcy and control during a challenging period. CARMESilk, aims to create a novel, patient-friendly technology, silk fibroin-based, that selectively captures doxorubicin within the hair matrix, via minimally invasive routes, thereby preventing hair loss while still maintaining chemotherapy efficacy. The fabrication of a 3D bioprinted scalp model using human hair follicles will establish the way for personalized CIA prevention strategies. CARMESilk is an interdisciplinary project combining nanotechnology, materials science, and bioengineering with a patient-centric approach. The project, as a Global fellowship, will be performed over three years, in US (2 years) and in Germany (1 year), with experts in the tissue engineering field. The achievement of CARMESilk goals will represent an improvement in patients' quality of life, a proof of concept of the technology that can be applied to other chemotherapy agents, highly impacting CIA prevention during an already challenging period.

Mots clés : nanoparticles, silk fibroin, 3d bioprinting, microfluidics

Participants :
- Université Friedrich-Schiller d'Iéna (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 401232.0 €
- Tufts University (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet VIMUS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Illegalized migrants (IMs) in urban settings face complex dynamics of visibility and invisibility, shaped by intersecting social identities like race, gender, class, and religion. While there is a rich body of literature on these heterogeneous experiences, existing research lacks a systematic analysis of how legal and policy infrastructures, along with intersecting identities, create different pathways for marginalization, stigmatization, and recognition within different urban contexts. (In)Visibility of Illegalized Migrants in Urban Settings (VIMUS) addresses this gap by drawing on interdisciplinary perspectives from Migration Studies, Critical Race Theory, Postcolonial Feminist Scholarship, and Urban Studies. It proposes a rigorous and innovative research approach structured around three main objectives: (I) analyzing legal and policy infrastructures through critical discourse analysis, (II) exploring relational dynamics of (in)visibility based on diverse urban contexts through thematic analysis, and (III)assessing different paths of intersecting identities shape (in)visibility of IMs across Boston, Birmingham, Barcelona, and Madrid though Qualitative Comparative Analysis (QCA) based on in-depth interviews with IMs. By challenging traditional binary notions of (in)visibility, VIMUS will generate critical, timely, and cutting-edge contributions to the understanding of urban inequalities and the socio-political dynamics of (in)visibility. The findings will guide policymaking and establish a theoretical framework that addresses the complex dynamics of (in)visibility within the context of marginalization, stigmatization, and recognition. Under the supervision of Prof. Sigona from the University of Birmingham, Prof. Lamont from Harvard University, and Prof. Thomann from the University of Konstanz, the fellowship will support my career goal of securing a tenure-track position in sociology at prestigious universities across the EU, or the UK.

Mots clés : irregular migrants, undocumented migrants, intersectionality, comparative sociology, qualitative comparative analysis qca , marginalization, stigmatization, recognition, visibility, invisibility

Participants :
- Université de Constance (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 454103.4 €
- Université Harvard (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet TESIFA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : CLOSED

In the next few years, electromagnetic and gravitational-wave facilities will uncover the elusive population of intermediate-mass black holes (IMBHs), the likely progenitors of present-day supermassive black holes. The upcoming detections promise to revolutionise our understanding of the black-hole population across the cosmic epochs; in preparation for this exciting future, it is now fundamental to shed light on the debated dynamical processes governing the growth of IMBHs. TESIFA is the long-awaited program that will clarify the timespan black holes spend in the intermediate-mass range, thus allowing for a solid interpretation of the upcoming IMBH detections. Leveraging the emergent picture according to which IMBHs primarily grow via stellar accretion, TESIFA will numerically model the rates of tidal disruption events (TDEs, thousands of which will be detected by the Vera Rubin Observatory starting next year) and gravitational-wave-induced extreme mass ratio inspirals (EMRIs, accessible to the planned LISA mission) about IMBHs. By combining this approach with state-of-the-art observations of nearby stellar systems, TESIFA will place novel constraints on the local IMBH population. Furthermore, TESIFA will investigate the ratio between TDE and EMRI rates as a function of the host galaxy properties, so that the observed TDE rates could be used to forecast LISA EMRI rates. Overall, TESIFA will lay the foundation for understanding the IMBH demographics and best exploiting their upcoming observations.  At Princeton University, the fellow will work alongside world-leading experts in the field of IMBH observations; she will learn the challenges affecting the observations of IMBHs and their hosts, as well as the capabilities and limits of electromagnetic facilities. The planned training will perfectly complement the fellow’s extensive numerical expertise, making her a well rounded scientist and placing her at the forefront of the research targeting IMBHs.

Mots clés : stellar dynamics collisional , intermediate mass black holes, n body simulations, fokker planck approach, tidal disruption events, extreme mass ratio inspirals, nuclear clusters, globular clusters

Participants :
- Université de Milan-Bicocca (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 288859.2 €
- Université de Princeton (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ThiMa (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

ThiMa challenges the assumption that action is a human prerogative by examining how everyday objects served as agents of transformation in late medieval societies. Investigating the boundary between material and human agency is particularly critical for the present, where new artificial intelligences call into question the very essence of being human. ThiMa reflects on these matters from another watershed moment in the redefinition of European material culture. Between the fourteenth and fifteenth centuries, everyday goods diversified and there was a significant increase of objects in circulation. This period can thus serve as a crucial laboratory to explore the impact of ordinary things on people’s social behavior and emotional life. For the first time, ThiMa examines objects as agents that interacted with individuals, mediating social relationships and moving emotions, (ways of) thinking, and perceptions through their peculiar material language. To investigate these questions, this project employs a bold new comparative framework in the richly documented but diverse environments of Tuscany and Sicily. This critical move away from siloed approaches to material culture allows us to better understand how socio-economic, institutional, and legal contexts influenced the complex relationship between human and things. The project interrogates a broad range of textual and material sources, using quantitative and qualitative methods, cutting-edge digital tools and drawing on a ground-breaking theoretical framework on material agency. Thanks to this novel approach, ThiMa will profoundly advance our understanding of how humans perceive and interact with their material environment from the medieval past to the present day.

Mots clés : objects material culture material agency social relationships gender roles emotions cognition italy north south socio economic divide late middle ages

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- Université Harvard (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet STAT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Visual objects in real life carry both perceptual and semantic information, which cannot readily be inferred from simple visual features and is based on prior knowledge. However, semantics is not a unitary concept; it can be separated into taxonomy (e.g., ducks and frogs are both animals) and co-occurrence (e.g., candles appear together with cakes). Previous studies have extensively characterized the role of taxonomy in visual cognition, while co-occurrence is less well-understood and more disputed. The aim of this proposal is to investigate the impact of object co-occurrence on object representation and visual cognition. The project has four objectives: First, I will use fMRI and EEG to identify where and when object co-occurrence statistics are represented in the brain, how they rival other competing organizations, and which mechanisms enable these representations. Objective 1 will provide a characterization of co-occurrence as a key organizational principle of object representation. Second, I will investigate how co-occurrence modulates neural competition between objects using fMRI. Objective 2 will clarify whether organizing objects based on co-occurrence can overcome information processing bottlenecks in the visual brain. Third, I will examine whether co-occurrence can facilitate conscious perception using the attentional blink paradigm and explore where and when neural representations of co-occurrence predict AB magnitudes. Fourth, I will investigate how and when co-occurrence impacts performance and neural processing in visual search using EEG. Objectives 3 and 4 will aid our understanding of how object co-occurrence contributes to human perception and cognition and thereby helps people to perform everyday tasks successfully. Overall, this research will provide a comprehensive characterization of how object co-occurrence in the world shapes human vision and open new avenues for explaining visual behaviors in natural environments.

Mots clés : semantics, co occurrence, object representation, consciousness, visual search, biased competition, fmri, eeg, mvpa

Participants :
- Université Justus-Liebig de Gießen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet BONEGEL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Defects that weaken bone tissue are a major challenge in orthopedic surgery as they can lead to fractures, significant morbidity, and reduced quality of life. Existing treatments do not provide the necessary mechanical strength, adaptability to dynamic bone remodeling, and osteoinductive properties required for effective bone regeneration. The BONEGEL project addresses this gap by proposing an injectable, self-healing hydrogel specifically designed to treat bone defects in non-weight-bearing bone. The BONEGEL approach includes several key innovations: a dextran-based hydrogel that utilizes the host-guest interactions of cyclodextrins to create a dynamic hydrogel that can adapt to irregular bone defects; the incorporation of laponite, a nanosilicate that improves the mechanical strength and osteoinductive properties of the hydrogel; and an effective and safe release of dexamethasone to accelerate bone regeneration. In addition, the project will optimize an ex vivo model for testing injectable materials for bone tissue engineering to ensure the efficacy and safety of the hydrogel prior to clinical application. This interdisciplinary project brings together expertise in materials science, tissue engineering and regenerative medicine to provide a safer and more efficient alternative to current treatments for bone defects and expedite its clinical application. By overcoming the limitations of existing therapies, BONEGEL has the potential to improve patient outcomes and shorten recovery times. This aligns with the EU's priorities for innovation and sustainability in healthcare, ultimately promoting a healthier population and better quality of life for patients. Beyond the scientific, societal and economic impact, this project will advance my career by providing me with the critical knowledge and experience I need to position myself as a leader in the biomaterials and tissue engineering fields and open doors to future academic collaborations and industry partnerships.

Mots clés : bone tissue engineering biomaterial hydrogel bone cyst bone regeneration cyclodextrin supramolecular hydrogel

Participants :
- Université d'Aalborg (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 263393.28 €
- Université Justus-Liebig de Gießen (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet DREAM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

This interdisciplinary project aims to improve response to depression treatment using the gut microbiota. About one third of patients with depression do not respond to treatment with Selective-Serotonin-Reuptake-Inhibitors (SSRIs). Moreover, side effects such as gastrointestinal complaints are common. The commensal gut microbiota, residing in the human intestinal tract in trillions, likely contribute to variation in treatment efficacy. This makes them a promising candidate to improve treatment response. The highly inter-individual variable gut bacteria collectively represent an enormous amount of genes, enzymes and transporters (outnumbering human genes by 10-100 times). Hereby, the gut microbiota are involved in processing of orally ingested compounds, and, through the communication highway called the gut-brain-axis, interact with the central nervous system. Anti-depressant medication such as SSRIs reduce gut microbial diversity and change community dynamics. For example, in vitro studies have shown unintentional effects of SSRIs in the gut on a bacterium with a human-analogous serotonin transporter. This negatively affects serotonin metabolism in the gut, potentially contributing to side effects and reduced treatment response. Other similar mechanisms may occur, yet very limited experimental experimental data exist mapping which and how gut microbiota are impacted by SSRIs. Moreover, hardly any studies link SSRI medication induced gut microbial effects to treatment response. Using clinical cohorts, I will dissociate gut microbial profiles of patients responding versus not responding to their SSRI medication. In a culturing experiment, fecal material of such responders and non-responders will be characterized in terms of growth profile after SSRI exposure, transcriptomic and metabolomics. Using these results, a probiotics product will be developed. This project contains clinical, microbial and applied work with great societal and economic potential.

Mots clés : gut microbiota, gut brain axis, depression, treatment response, ssris

Participants :
- Winclove holding bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Johann Wolfgang Goethe de Francfort-sur-le-Main (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 237109.2 €
- Université Eberhard Karl de Tübingen (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet FLEXNEUROCOMP (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Imagine that you have just rung at a doorbell and no one has answered the door. Is there anybody home? How many times should you ring? One simple solution is just to ring several more times and wait. Yet, to save time and make sure that no one is home, you could also consider whether there is a light inside the house or whether there is a car parked in front. Although such situations are ubiquitous in our daily life, relatively little is known about how different decisions are implemented in the brain and how they flexibly inform behavior. This proposal directly aims to characterize decision variables both at the behavioral and neural levels to understand how the brain flexibly switches between them. We will combine sophisticated mice behaviors that accommodate multiple decision variables with innovative models of dynamical systems, and leverage the latest progress in electrophysiology and optogenetics to record and manipulate large ensembles of neurons simultaneously across multiple brain regions. This work will test the overarching hypothesis that the premotor cortex, thought to implement the intention to act, is a reservoir of decision variables that flexibly routes the employed decision variable to motor regions. Our highly multidisciplinary team, which consists of the researcher with productive records in systems neuroscience, the supervisor who is a specialist in cognitive neuropsychology, and the secondment supervisor who is a renowned theoretical neuroscientist, is well armed to successfully carry this project. Our results should deliver a new conceptual framework for understanding adaptive behaviors and their neural bases. This project will also provide a direct window into the neural mechanisms underlying individual variations in decision making and how actions may depart from a healthy behavior when erroneous or maladaptive strategies are used, of relevance for explaining diversity in human behavior and mental health.

Mots clés : electrophysiology, optogenetics, premotor cortex, adaptive behavior, decision variables, mouse

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 124505.36 €
- Université Eberhard Karl de Tübingen (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MIME (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project will study the cultural interrelations between sacred music and lay vernacular lyric by uncovering and analysing the melodic imitations that occur between the two repertoires. The research will focus on lyric, music, and manuscript sources produced in France and Occitania from the beginning of the 11th to the end of the 13th century, with the aim of understanding to what extent troubadour and trouvère poetry (which was always accompanied by music) depended on the Latin ecclesiastical cultural humus, its forms and its techniques. Imitation and memory were constitutive aspects of artistic creation in the Middle Ages, which was more often driven by an attraction for an established tradition rather than the perceived need for innovation. The project will exploit digital technologies available and develop new computational perspectives to analyse large corpora of liturgical and vernacular music in order detect concordances between melodies, with the aim of assessing the intertextual, literary and ideological implications of musical reuse. With this goal, the researcher will create a sophisticated searching tool able to detect similarities in melodic sequences which will take into account musicological principals as well as the variability inherent to the process of manuscript copy. A secondment period at McGill will enable the fellow to use Optical Music Recognition to enlarge the dataset of encoded melodies at an unprecedented speed and accuracy. This is expected to substantially increase the discovery of musical correspondences. The research will enhance our understanding of the dialectic between imitation and creation in the Middle Ages, and contribute to define the osmotic, yet conflicting, relationship between lay and religious culture and their creative environments throughout the later middle ages.

Mots clés : digital humanities

Participants :
- Université McGill (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Eberhard Karl de Tübingen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177257.36 €