Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CIDoRa (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

In times of increased mobility, urbanisation and sociocultural tensions, the way professional media as information providers and public watchdog present diversity has implications for social cohesion and for how young people perceive identity and society. Against this background, youth radio stations, which have become increasingly interactive and collaborative in the digital age, are an important point of orientation for many young people living in ethnically and linguistically diverse spaces, often struggling to ‘fit in’, and looking for reliable information and guidance. Despite German broadcasters' statutory and moral obligations to promote social cohesion and to contribute to building a non-discriminatory society in Germany, the media's representations of ethnic diversity have frequently been criticised. Little is known, however, about what a meaningful engagement with diversity means for journalists and how they try to create social cohesion through their work. Through linguistic ethnography at a German youth radio station and a critical discourse analysis of media messages, CIDoRa will provide new insights into the linguistic and semiotic practices of radio content production to explore how journalists construct and negotiate a collective urban youth identity with their diverse audience and thereby try to create a sense of community. In this context, my project will shed light on possible issues that can lead to an unbalanced and negative portrayal of ethnic and linguistic diversity on youth radio to foster a more meaningful engagement of journalists with diversity. By developing approaches for diversity-oriented communication, CIDoRa responds to timely social concerns around difference and voice in a mobile world fraught with deepening division. The results of my project will be disseminated through academic publications and outreach activities for journalists organised in collaboration with media stakeholders.

Mots clés : critical sociolinguistics, linguistic ethnography, critical discourse analysis, multimodality, youth, identity

Participants :
- Université de Limerick (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet PURC (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The Politics of Urban Regime Contestation provides the first systematic assessment of attempts by Spanish New Municipalist movement-parties to consolidate progressive urban regime change between 2015 and 2019. New Municipalism represented a political wave of astonishing proportions, unseating neoliberal regimes led by traditional political parties in eighteen cities with more than 20,000 inhabitants, including key urban centres such as Barcelona and Madrid. Municipalist administrations experimented with the co-operative economy, sustainability initiatives, feminism and democratic revitalization. They produced multiple cases of attempted urban regime change: understood as the process of creating resource coalitions capable of transforming urban governance and political economy. This study provides novel and timely data and theory to understand the politics of urban regime contestation. The success of municipalist platforms in 2015 provided inspiration for an international movement, but is marked nationally by widespread electoral defeat in 2019. Municipalist administrations achieved electoral continuity in just two cases: Barcelona and Cadiz. Outcome variation provides opportunities for comparative analysis into the dynamics of urban governance continuity and change. Theoretically, urban regime theory is used in-order-to understand how New Municipalist coalitions and agendas interacted with urban governance relationships and institutions. The project builds on empirical pilot research into two cases, using a tried and tested methodology, recently published in Urban Studies, adding Qualitative Comparative Analysis to explain varying degrees of success across the entire population of cases. In using this theory and method the project promises to provide an over-arching yet detailed assessment of the topic. It will develop knowledge critical for deepened urban democracy, sustainability and social justice: a valuable contribution to Horizon Europes' strategic ambitions.

Mots clés : urban regime theory, new municipalism, urban political economy, participatory democracy, qualitative comparative analysis

Participants :
- Université autonome de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
- Université de Southampton (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Glyco-Biotic (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Antimicrobial resistance (AMR) represents a significant health and economic challenge worldwide. Due to the fact that bacterial infections affect most people at some point in their lives, methods for specific recognition and targeting of bacteria are of key importance in developing approaches to counter the growth of AMR, where the discovery of novel antibiotics represents a global challenge in urinary tract infections (UTI). Progress in bioorganic synthesis has provided access to knowledge of the interactions between receptors (lectins) and specific carbohydrate on the outer membrane of bacteria. Cell surface carboAntimicrobial resistance (AMR) represents a significant health and economic challenge worldwide, where the discovery of novel antibiotics represents a global challenge in urinary tract infections (UTI). Progress in bioorganic synthesis has provided access to knowledge of the interactions between receptors (lectins) and specific carbohydrate on the outer membrane of bacteria. It is commonly accepted that this process requires an exquisite carbohydrate specificity of bacterial surface lectins and offer an opportunity to develop very selective probes that could target specific bacteria by the development of glycan mimics as potential drug candidates. Interestingly, some bacterial strains of E. coli are specific for galabiose. In order to design a drug candidate, it will be synthesized various glycomimetics with a common core of galabiose, which will be conjugated with a fluorescence probe to evaluate their binding affinity. Our hypothesis in this project resolves around the generation of a new class of antibiotics through the combination of known antibiotic drugs with the lead glycomimetics and allowing the drug delivery to the desired location. This project aims to test both aspects of the discovery of new antibiotics employing bioorganic approach based on the design, synthesis, diagnostic assays and drug delivery analysis of appropriate molecular models.

Mots clés : carbohydrate chemistry, glycomimetics, multivalency, glyco probes, antimicrobial resistance

Participants :
- Université de Bristol (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet EcoPDI (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

In the world, the phrase "we are going through a major food crisis" is becoming more and more common. This is because our society is faced with managing an exponentially growing world population and a decrease in arable land per person. This rising demand for food in developing countries is at risk due to plant diseases induced by bacteria, fungi and viruses. At the same time, food is traded globally, enabling the dissemination of dangerous microorganisms worldwide. Therefore, creating alternative and ecologically friendly antibacterial and antifungal treatments is essential to address the growing demand for safe and healthful plant-based foods. EcoPDI aims to solve this current and critical problem by developing new earth-abundant metal compounds with natural ligands as photosensitizers for photodynamic inactivation (PDI) of resistant bacteria and fungi. For this, EcoPDI focuses on the "Sustainable-Economic-Applicable" triple approach. Thus, this multidisciplinary project will develop new sustainable treatments that avoid the use of pesticides and employ sunlight to activate the antimicrobial activity of the compounds, will use cheap earth-abundant metals and improve the disadvantages of natural compounds, and apply the new photosensitizers directly to plants through the planned secondment. EcoPDI includes both the transfer of knowledge to the host institution and the training of the candidate in new techniques and methods. The findings have the potential to open up space for additional basic and applied research on PDI in plant protection and food safety. This proposal responds to the European Green Deal which has as its objective to restore damaged ecosystems and bring nature back across Europe and reduce the use and risk of chemical pesticides by 50% by 2030.

Mots clés : earth abundant metals, photodynamic inactivation, natural compounds, antibacterial, antifungal, sustainable, plant protection, food safety

Participants :
- Université de Salzbourg (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École nationale supérieure de chimie de Paris - PSL (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet GrindTrace (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Grinding technology (i.e. querns and handstones) is an integral part of the material culture of prehistoric societies, involved in numerous human productive activities, incorporating socioeconomic and cultural significance. For decades the study of grinding systems in the context of Greek prehistory remained limited with only a few exceptions. The GrindTrace project aspires to change the research landscape and enhance our knowledge regarding this understudied field, at the same time shedding light on the yet-little-known transitional period from the Neolithic to the Bronze Age. What first appeared to be a gap of about 500-700 years in the evolution of prehistoric societies in Greece, from the end of the 5th to the late 4th millennium BC, is now seen as the result of a combination of low visibility and insufficient research. The assemblage to be analyzed includes over 500 specimens originating from six sites in northern and central Greece. The following lines of investigation will be pursued: a) technological and functional study of the selected artifacts; b) experimental investigation of parameters influencing the grinding systems; c) petrographic characterization of the tools' raw materials; and d) combined analysis of contextual, spatial and temporal information. The proposed multidisciplinary approach integrates elements of archaeology, geology, GIS and tribology, and aspires to use the micro-scale to talk about the macro-scale (human behavior patterns, settlement organization, temporality of habitation). In this framework, I will have the chance to explore various analytical techniques, some of which are particularly underdeveloped. This will help me establish a novel methodological approach, which, besides boosting my potential to lead cutting-edge interdisciplinary research in the future, will contribute to the internationally growing functional studies, enhancing at the same time similar research prospects in the field of Greek prehistory.

Mots clés : material culture, functional analysis, anthropology of technology, social relations and meanings

Participants :
- Université Paris 1 - Panthéon Sorbonne (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
- Centrale Lyon (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet POPULAV (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

One of the most pervasive effects of decade long overexploitation of marine fish is the truncation of size distributions in affected populations. Today, many populations of commercially important species, such as Atlantic cod (Gadus morhua), consist of smaller individuals than just a few decades ago. Concurrently, a general decline in recruitment has been observed with severe consequences for population growth and productivity. These observations have led to the formulation of the Big Old Fat Fecund Females (BOFFF) hypothesis, which states that older, larger females contribute disproportionally more to the recruitment because of their increased mass-specific fecundity and production of more viable offspring. The first part of the hypothesis has been tested and confirmed, while the considerably more challenging test of superior offspring survival is hindered by the inability to link individual offspring caught in the open sea to the size of the mother. In the POPULAV project, I will use size-specific natural biochemical markers (stable isotopes) to link maternal size to larval viability. Larvae are provisioned with the maternal isotopic signature via nutrient transfer from maternal gonads to the eggs/larvae; A promising, novel tool to provide a robust test of the BOFFF hypothesis. The objectives are to (1) confirm the size-effect on maternal gonadal isotopic signature, (2) assess size-dependent stable isotope transfer in laboratory experiments, (3) assign wild-caught larvae to the size of its mother using stable isotope profiles, and (4) use a simple model to estimate the effect of population size truncation on larval viability. Data obtained in POPULAV will advance our understanding of how size truncation affects larval viability and thereby recruitment. This knowledge can support decision making and fisheries management, and place its coordinators and the EU at the forefront of international efforts for understanding the impacts of fishing on our marine resources.

Mots clés : maternal provisioning, larval quality, biochemical markers, atlantic cod, fish ecology

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet ClaN-Bi (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The amino moiety is a fundamental functional group with essential functions across the chemical and life sciences, including agrochemical and pharmaceutical research and manufacture, polymer chemistry, and biochemistry. Therefore, there is a well-acknowledged need for new and more sustainable methods to construct C-N bonds. Most procedures for C-N bond formation rely on the use of toxic and expensive transition metal catalysts, which are notoriously impeded by undesired β-hydride elimination and/or poor site selectivity. Consequently, the search for new and more sustainable catalytic paradigms in synthesis has shifted towards the main group elements. Bismuth was recently demonstrated to moonlight both as a noble or first row transition metal, displaying reactivity in 1-electron and 2-electron processes at will. This dichotomy in reactivity of low-valent Bi complexes could potentially be crucial in addressing the long-standing issues encountered in C–N bond formation. Thus, ClaN-Bi aims to discover and develop new catalytic C–N cross-coupling reactions to generate both aliphatic and aromatic amines by exploiting the new Bi(I)/(II)/(III) redox platform.

Mots clés : catalysis, bismuth, radicals, c n bond

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet BottomUpFly (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Locomotion is one of the most relevant tasks of nervous systems, allowing animals to approach food, locate a mate, and escape predators. Most types of locomotion, like walking and flying, are based on rhythmic body movements generated by local premotor networks in the nerve cord, whereas the goal of where to move is generated in the brain – e.g., a hungry fly visually locating a food source. For flexible, goal-directed locomotion, the communication between the brain and premotor networks in the nerve cord must be bidirectional. However, in contrast to descending commands from the brain, little is known about proprioceptive signals ascending from the nerve cord's premotor networks. We hypothesize that ascending information plays a vital role in decision-making and action selection processes. Before commanding the body to change direction, or to keep it from doing so to maintain a straight path, brain circuits need to consider the current stability of the body, its walking speed and direction. In this project we aim to characterize the ascending signals determining the direction of upcoming turns if the fly’s trajectory deviates from the intended one. We will identify the source of the ascending information, characterize functional differences of ascending information pathways, and determine their integration within brain circuits by harnessing the vast toolkit of Drosophila melanogaster and combining the expertise of the Chiappe group on sensorimotor integration in the brain of walking Drosophila with mine on networks controlling walking in the ventral nerve cord. This work will deepen our understanding of the function of proprioception in higher order brain functions, action selection, and decision-making.

Mots clés : decision making action selection proprioception ascending information motor control

Participants :
- Champalimaud Foundation (Portugal) — Coordinator, beneficiary, Recherche, subvention : 156778.56 €
Projet IP2adapt (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Everyday behaviours, like mastering dance moves or hiking through uneven terrains, require motor learning. Although essential, cellular and circuit mechanisms for this type of learning are poorly understood.  In the context of locomotion, learning can be induced on a split-belt treadmill, where each side of the body moves at different speeds; this is currently used as a rehabilitative therapy in patients presenting asymmetric gaits following brain damage. The receiving laboratory recently showed that mouse locomotor learning is remarkably similar to humans. Regaining gait symmetry is achieved through specific adjustments in interlimb coordination. Moreover, the laboratory demonstrated that this form of motor learning depends critically on intermediate cerebellum. Strikingly, spatial and temporal components of learning (i.e. “where” and “when” paws land) proceeded independently, suggesting that they might be dissociable at the neural circuit level. However, how cerebellar outputs act to calibrate spatiotemporal coordination between limbs is unknown.  IP2adapt aims to decipher the functional connectivity of cerebellar output circuits conveying corrective calibration signals to modify locomotor movements in space and time. Specifically, we will: 1) Use advanced viral tools to map output circuits downstream of the cerebellum and identify candidates for spatial and temporal calibration signals; 2) Use high-resolution quantitative behavioural analysis and cutting-edge circuit manipulation to test specific functional roles of projection-defined subsets of cerebellar outputs in locomotor learning; 3) Use state-of-the-art recordings of these functionally-defined neurons during learning to understand how the cerebellum transforms locomotor errors into spatial and temporal calibration of limb movement. This work will reveal unprecedented insights into neural circuits that ensure the adaptability of motor commands, with direct relevance for rehabilitative therapy.

Mots clés : motor learning, locomotion, cerebellum, neural circuits, viral based tracing, neural recordings, mouse

Participants :
- Champalimaud Foundation (Portugal) — Coordinator, beneficiary, Recherche, subvention : 156778.56 €
Projet SuperLoco (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Motor learning is essential to move in a continuously changing environment, but the underlying neural circuit mechanisms are still poorly understood. This is critical for locomotion, a fundamental but complex behavior, which requires precise control of whole-body movements at the same time.  The cerebellum plays a key role in motor learning, supposedly generating corrective movements through supervised error-based mechanisms in response to perturbation. For simple tasks, climbing fibers originating in the Inferior olive drive supervised learning, generating changes of cerebellar activity and corrective responses.  During locomotion, perturbations cause gait asymmetries, which can be externally induced in a split-belt treadmill with belts running at different speeds. The host laboratory developed a split-belt treadmill to study locomotor adaptation in mice, showing that it is similar to humans, occurs through motor corrections with complex spatiotemporal dynamics, and is driven by the cerebellum. However, the underlying neural bases are unknown.  SuperLoco aims to identify supervised mechanisms for locomotor learning, exploiting the synergy between cutting-edge technologies to interact with neural circuits and computational neuroscience tools. Specifically, we will: (i) record climbing fiber and cerebellar activity during locomotor learning in mice with high-yield electrophysiology, (ii) simulate locomotor learning in a bioinspired spiking neural network of the cerebellum with climbing fiber-supervised plasticity, (iii) optogenetically stimulate climbing fibers to induce locomotor learning based on model predictions. Our main hypothesis is that the timing of climbing fiber signals determines changes of cerebellar activity through supervised plasticity driving locomotor learning.  SuperLoco outcomes will shed light on neural mechanisms for complex whole-body movements, fundamental in neuroscience and crucial for treatment of movement disorders.

Mots clés : motor learning locomotion cerebellum neural recordings spiking neural networks supervised plasticity optogenetics

Participants :
- Champalimaud Foundation (Portugal) — Coordinator, beneficiary, Recherche, subvention : 156778.56 €