Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Stem2MorphoMap (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Tissue development requires the orchestration of stem cell differentiation and morphogenesis, a process that is conspicuously observed in mammary gland (MG) branching. The MG develops from an embryonic bud of mammary stem cells (MaSCs). Although these stem cells are initially bipotent, giving rise to the outer (basal) and inner (luminal) layers of the adult gland, they become lineage restricted very early in embryogenesis, at around the time of the onset of branching morphogenesis. The timing of lineage restriction coincides with the differential expression of cell polarity and cell adhesion transcripts. Branching morphogenesis then relies on differential cell division, as well as cell rearrangements and migration, but the mechanisms regulating this process in the embryo remain poorly understood. Based on these observations, we postulate that basal-biased and luminal-biased MaSCs have distinct molecular features during branching morphogenesis. We therefore propose to functionally link the signaling pathways involved in restriction of stem cell potency to the cellular dynamics that ensure branching. To this end, we will characterize the dynamic behaviour of individually labeled MaSCs during the growth of embryonic MG explants and assess their fate, creating a complete fate-behavior map of MG development. Through genetic manipulation, we will probe how cell adhesion, migration, and division impact on lineage specification and tissue growth. Simultaneously, we will skew stem cell differentiation trajectories and assess their influence on cell behavior and organ shape. The outcomes of this project will provide novel insights into the coordinated developmental programs governing stem cell fate and morphogenetic events, both essential to tissue formation. Moreover, they might uncover potential connections to cancer, where differentiatiom and cell polarity play pivotal roles.

Mots clés : branching morphogenesis, stem cell plasticity

Participants :
- Institut Curie (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet BALNEa (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project will be hosted by the University of Bologna's Department of History and Cultures, supervised by Prof. Isabella Baldini, a leading scholar in Late Antique archaeology. It aims to investigate the decline of Roman public baths (balnea, in Latin). Baths held a crucial role in fostering sociability, being accessible to all social classes, thus becoming integral components of urban landscapes. While their decline during Late Antiquity is often attributed to cultural shifts tied to the rise of Christianity, my research aims to uncover environmental and economic factors that contributed to this decline. My study will chiefly concentrate on spatial volume of the thermal bath’s rooms, the energy consumption required for their heating, and the production cycle for procuring fuel materials within specific ecological settings. I’ve chosen Sicily as a case study due to the context comparable with other Mediterranean regions and the wealth of thermal complexes unearthed, a suitable number within the 3-year MSCA-PF. Methodologically, the research will first rely on the available scientific literature on the topic. Subsequently, drawing upon my background as an architect, I will delve into the technical and stylistic aspects of energy-efficient practices in designing ancient buildings, utilizing technologies such as surveying, 3D reconstruction, and simulations. The archaeological remains will be analysed through the creation of digital models to reconstruct their structural characteristics and operational system performance. To acquire the latest survey and 3D reconstruction technologies, I will conduct the Outgoing phase at the ‘Institute for Digital Exploration’ at the University of South Florida, directed by Prof. Davide Tanasi. Additionally, during a Secondment at the University of Catania’s ‘Energy Sustainability & Environmental Control Laboratory’, guided by Prof. Francesco Nocera, I will assess energy efficiency and economic sustainability in ancient buildings.

Mots clés : late antiquity late antique baths roman baths archaeology of architecture 3d models simulations ancient energy efficiency ancient economic sustainability architectural energetics

Participants :
- Université de Bologne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 396991.08 €
- Université de Catane (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Floride du Sud (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet DESULITROI (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Epithets express gods' powers. Focussing on qualities needed for a particular ritual, they create a more effective interaction with the gods. This project will provide a catalogue of Sumerian divine epithets from a corpus of ca. 650 previously translated literary texts and royal inscriptions (ca. 2500-1600 BC). The objectives of the project are: 1) to create an online database of divine epithets found in Sumerian literary texts and royal inscriptions from the Old Sumerian to the Old Babylonian period (circa 2500–1600 BCE) which will be made available via the Leipzig University website; 2) to investigate their structure; 3) to analyse the relationship between epithets and the intentions of the texts, considering their function in narrative passages, human-divine communications and intertextuality. A relevant innovative aspect of the proposal is the interdisciplinary approach which combines the Sumerological approach, based on philology, with the methodology and theoretical frameworks developed in classical and religious studies as well as Jewish studies. Despite their role in understanding Mesopotamian religion, Sumerian divine epithets have not been systematically collected. Hence, the online database is a major desideratum in Ancient Near Eastern Studies and will fill an academic void, providing for the first time an indispensable tool for further research on Mesopotamian religion and languages and comparative religious studies. New translations and editions of Sumerian texts from the last 30 years and a better knowledge of the language now allow us to achieve a comprehensive catalogue of divine epithets. Being innovative, the project will increase the level of research excellence in European humanities. Being ground-breaking in its field, the online database of Sumerian divine epithets will contribute meaningfully to the Digital Humanities in Europe and worldwide.

Mots clés : divine epithets sumerian literature mesopotamian religion sumerian language

Participants :
- Université de Leipzig (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet MEASURE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Complications occur in 5-10% of pregnancies, resulting every year in 2.6 million stillbirths and 303,000 maternal deaths. There is established evidence that complications and stillbirth are associated with abnormal development/adaptation of the cardiovascular system (CVS) during pregnancy. However, the literature lacks a holistic approach and only a few limited aspects have been investigated. Therefore, MEASURE aims at pursuing a holistic investigation of the CVS and the coupling between its subsystems (fetal and maternal CVS), mediated by the uterus and placenta. Synchronized Doppler and electrophysiological acquisitions will be performed to produce a unique dataset for the identification of a mathematical model describing the CVS. This will be achieved through robust and accurate extraction of time series representing the characteristics of the CVS in healthy pregnancies. Through an innovative aggregating strategy proposed to improve clinical reliability, the obtained model will be translated into a coupling map, i.e., a graphical representation of the relationships between the CVS subsystems and their variables. Being more intuitive and easier to interpret, this representation is particularly suitable for its clinical use and uptake. Finally, the comparison between the coupling maps of healthy and complicated pregnancies will allow identifying anomalies in the interactions between the CVS subsystems and designing/training a machine learning classifier to automatically discern between them. The outcomes of MEASURE will improve our understanding of the physiological mechanisms underlying pregnancy and original causes of complications, paving the way for the development of novel, powerful, diagnostic tools for timely diagnosis and, possibly, prediction of pregnancy complications. The support of academic, industrial, and clinical partners will provide all the instruments to achieve the envisioned scientific breakthroughs and favour their clinical translation.

Mots clés : modeling cardiovascular system pregnancy monitoring perinatal medicine pregnancy complication model identification coupling analysis biomedical engineering

Participants :
- Koninklijke Philips (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de technologie d'Eindhoven (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203464.32 €
Projet I3 (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Given the escalating global burden of valvular heart disease and the pressing need for living heart valve replacements, I decided to focus my research on this healthcare challenge by acquiring new skills through advanced training and international interdisciplinary collaborations. My proposal I3 combines the design and application of a novel bioreactor for assessing tissue engineered heart valves (TEHVs) by highly advanced magnetic resonance imaging (MRI) to kickstart the innovation cycle in in-vitro experiments. Especially young patients with valvular heart disease will profit from TEHVs as they suffer from current heart valve replacements lacking the ability to self-repair and growth as well requiring the life-long intake of anticoagulants. Leveraging the high-dimensional, non-invasive analysis potential of MRI, my I3 proposal establishes new innovative tools for TEHV research to enable new insights in the resulting hemodynamics downstream of TEHVs, close the optimization loop in-vitro using patient-specific boundary conditions and reduce the need for ethically and monetary challenging animal experiments. Building on my expertise on advanced MRI, I will acquire new skills to develop a novel MRI-compatible bioreactor in the project. Enabling in-vitro experiments with high precision and repeatability, the imaged flow field in the bioreactor allows me to select and optimize a TEHV for specific hemodynamics of patients. In-vivo MRI-enabled feedback of the resulting hemodynamics offers further diagnosis. Furthermore, in-vitro and in-vivo measurements offer important information for optimization of TEHVs for patient-specific treatments. I will use the knowledge and skills gained from this inter-sectoral and inter-disciplinary project for my next career steps (incl. submission of an ERC starting grant) in the field of biomedical engineering research aimed at providing all patients with a suitable heart valve replacement. I3 is a major step towards making this a reality.

Mots clés : cardiovascular imaging, tissue engineered heart valves, congentinal heart disease, mri flow imaging, pc mri, patient specific, real world problems, sdg 3 4, optimization, bioreactors, biomimetics

Participants :
- Federal Ministry for Economic Affairs and Energy (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
- Université de technologie d'Eindhoven (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet LINCARE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The critical challenges posed by the growing migratory movements, in terms of linguistic and cultural collisions, raise the need to deeper understand the acculturation processes faced by groups of migrants while settling in a new social and cultural context. These may encompass certain levels of acculturative stress, which have an impact on migrants’ psychological well-being and are reflected, among other things, in the linguistic outcomes of migration. Previous studies demonstrated a positive link between bilingualism and higher well-being levels, though only considering self-assessed language competence and use, lacking empirical support from real communicative interactions. Thus, the LINCARE project aims to establish whether specific language contact phenomena, found in interaction and typical in migration contexts, can serve as a reliable tool to assess levels of well-being in immigrant groups, by investigating their relation with cultural and socio-psychological aspects, through advanced multivariate analysis techniques. It also seeks to explore whether bilingual practices positively correlate with higher levels of well-being. In so doing, the project will bridge gaps in existing linguistic, cultural, and psychological research and create an integrated framework. It will contribute to inform policy-makers about the multifaceted consequences of migration and possible stress factors affecting migrants during settlement and, in turn, society at large. Therefore, as the United Nations and European Union strive to reduce inequality, promote multilingualism, and protect minority rights and cultural heritage, this project will also contribute to these global challenges. Moreover, working on this project at Tilburg University will enhance my expertise in linguistic analysis and provide me with additional knowledge of the cultural and psychological aspects related to migration. This transfer of knowledge will foster research and innovation on these topics.

Mots clés : sociolinguistics language contact phenomena code switching italo romance varieties psychological well being acculturation acculturative stress cultural heritage multivariate analysis

Participants :
- Université de Tilbourg (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187624.32 €
Projet GenderGapsInnovation (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : TERMINATED

Innovation is widely recognized as a key driver of economic growth. However, large gender disparities persist in crucial components of the innovation ecosystem: entrepreneurship and academic science. In the EU, for instance, women represent only 34% of entrepreneurs. Globally, female-owned businesses tend to be smaller, less profitable, and face challenges raising external funding. This disparity also extends to academic innovation, where women remain underrepresented and are less likely to receive credit for their research. Moreover, critical research areas, such as health issues that predominantly affect women, remain under-studied. Given the implications for economic growth and societal wellbeing, the overarching goal of this research is to understand the determinants of the gender gaps in entrepreneurship and science as well as their consequences for innovation.  To address these knowledge gaps, during my MSCA fellowship at Tilburg University, my research objectives will (1) explore potential determinants of the gender gap in entrepreneurship; (2) investigate interventions and policies that can address these gaps; and (3) understand the consequences of the lack of gender diversity in innovative activities, especially in academic science, on the production of ideas and how ideas by women are perceived. To achieve these objectives, I will conduct three interconnected studies. In the first study, I will use Dutch microdata to assess the role of motherhood and the impacts of maternity leave policies on female-owned businesses. Second, I build upon an experiment in Ghana to evaluate how access to online networking can close the gender gap in business performance. Finally, I will investigate how increasing gender diversity at universities can impact research topics and the recognition of female-authored work. Together, these investigations delve into gender disparities in entrepreneurship and refine our understanding of how diversity fosters innovation.

Mots clés : gender economics

Participants :
- Université de Tilbourg (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203464.32 €
Projet GenderedTimeUse (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

Time allocation among household members, across various paid and unpaid activities throughout the day, gets negotiated through individual preferences, gender norms, and the bargaining power of respective individuals. The time allocation across activities by gender, age, and location is associated with Sustainable Development Goal 5 on Gender Equality (Indicator 5.4.1), and the differences in time allocation by gender are linked to the process of economic development of a country. Despite the societal and economic significance, scholarly discourse on time use is until now mainly restricted to developed countries, with a lack of data hampering the analysis of intrahousehold time allocations in developing-country contexts. In this project, I will use Time Use Survey 1998-99 and 2019 data from India, together with the National Family Health Survey II (1998-99) and V (2019-21) data from India to examine the intrahousehold allocation of time across paid and unpaid activities. I will use econometric specifications to examine the variation in paid work, unpaid work (domestic work, care, other unpaid work), leisure, and necessary activities by considering the intersectionality of gender with socio-economic identities, location, and their change over 1998-99 and 2019. In addition, I will explore how various measures of married women’s power – women’s education level relative to their husbands and mothers-in-law, their decision-making autonomy, and freedom of movement outside the house - influence intra-household time allocations across activities. This project moves beyond the narrative of power previously explored in developed countries and examines the forms of power that influences women’s time allocations in a developing-country context. The approach of this project is likely to be relevant for other countries that are governed by similar gender norms and the findings will add to the evidence base for monitoring the global progress toward SDG 5 and specifically for India.

Mots clés : time use, paid work, unpaid work

Participants :
- Université de Tilbourg (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203464.32 €
Projet IDEA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

This research project explores the consequences of institutional discrimination, i.e., discriminatory treatment of individuals (based on their membership to a certain group) perpetuated by organizations. In particular, the project explores two policies that created institutional discrimination, and aims at causally estimating the impacts on the socio-economic outcomes of affected individuals. In order to causally estimate the effects of institutional discrimination, I will make use of rich administrative data from the Netherlands and exploit quasi-random variation in exposure to institutional discrimination, induced by the Dutch institutional context. In the first work package, I will use a combination of rich administrative data, machine learning methods, and a difference-in-differences research design, to study the effects of the “Dutch childcare benefit scandal”. This scandal arose when the Dutch tax authorities started to target fraud investigations (and heavily punish even small administrative mistakes) using an algorithm that was biased against individuals with a non-Dutch nationality. In the second work package, I will use rich Dutch administrative records matched with unique data from the social housing corporation in Rotterdam, and a difference-in-differences research design, to study the effects of the “Rotterdam Act”. This Dutch policy created institutional discrimination by prohibiting access to social housing to some groups of individuals in disadvantaged neighbourhoods. Both studies will investigate the effect of institution discrimination on a wide array of socio-economic outcomes, including labour market participation, welfare receipt, wealth, health, and criminal involvement. The results of this project will be of interest to a wide audience as they will contribute to our understanding of how institutional discrimination might affect vulnerable groups in the population.

Mots clés : institutional discrimination public policy natural experiments

Participants :
- Université Érasme de Rotterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203464.32 €