Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MARKETING EXPENDITUR (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

With increased competition intensity in almost all industries, nowadays no one could deny the importance of marketing function to a firm in driving sales. However, overspending in marketing has been an immanent problem that prevails in firms across various industries. Overspending in marketing not only erodes firms’ profit, but is also harmful to social welfare. Unlike price reduction related promotion (bundling, coupon, etc.) that benefits consumer eventually, overspending in marketing mainly composed of activities such as advertising and marketing campaigns is a huge waste to the society as a whole. From the regulator’s perspective, it is not feasible for regulators to interfere with firms’ decision on marketing expenditure. The goal of this research is to find a way to help firms to set a marketing expenditure that aligns firms’ behaviour with regulators’ expectation while taking into consideration of firms’ inherent incentive to maximize profit. A large body of literature has devoted to address the question what the optimal marketing expenditure a firm should set to reach maximal profit. However, the normative criteria to set an optimal marketing expenditure by the previous papers 1) too sophisticated to adopt or implement in reality 2) is derived based on a set of very constrained assumptions, which make the findings practically irrelevant. In our study, instead of coming up with certain techno-economic criteria for firms to follow, we zoom into a firm and examine the process how a marketing budget is decided. By studying the ‘task environment’ that a marketing budget is produced, we are able to 1) obtain insights on factors that lead to overspending in marketing 2) give feasible and actionable advices to firms that suffer from inefficient marketing expenditures.

Mots clés : marketing expenditure, marketing budget, marketing and finance interfaces, behavior integration, contingency factor

Participants :
- Erasmus University Rotterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet CaMILLET (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

With osteoporosis becoming an increasing threat to human health, this project is directed towards finding an inexpensive solution to this problem using crop genetics. Biofortification of human diet with food that are naturally rich in Calcium (Ca) is proposed. Among all cultivated cereals, finger millet (Eleusine coracana), an annual small millet of Africa and Asia, has been found to have the highest concentration of Ca (350mg/100g) in its grains. This proposal aims to investigate the genetic variations of Ca accumulation in finger millet germplasm using chemical phenotyping and genomics, and to use this knowledge in further improving the concentration of this micronutrient in finger millet and other staple crops. Specific objectives of the study are: (1) to explore the extent of genetic diversity for Ca content present in world collection of finger millet germplasms; (2) to identify genomic regions associated with Ca accumulation in finger millet grains using next generation sequencing, chemical phenotyping and GWAS analysis; (3) to identify and validate candidate genes underlying genomic regions found to be associated with Ca accumulation in finger millet; and (4) use comparative genomics to identify similar genes and processes in staple cereals like wheat, rice, barley or oats grown in Europe. The project will identify genes involved in Ca accumulation in crops and the prospects of their breeding into new varieties through plant breeding. Such crop varieties will benefit the smallholder farmers who will grow them (by adding value to their food products) and also provide valuable, superior raw material to industries for developing functional food rich in Calcium. Availabilities of such food and food products will increase Ca consumption and reduce the health and economic impacts of osteoporosis.

Mots clés : finger millet, grain calcium content, osteoporosis, functional food, germplasm, genetics, genomics, candidate genes, genetic variations, plant breeding

Participants :
- Aberystwyth University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet TREGinAD (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

With populations ageing, Alzheimer’s disease (AD), for which there is still no cure, has become a major public health problem in Europe. This is partly due to the neglect of the role of the immune responses to the build-up of cerebral Aβ-the pathogenic agent triggering AD. Clinical trials for vaccines aimed at reducing cerebral Aβ were accompanied by severe side effects due to improper neuroinflammation. While the input of microglia, the brain resident innate immune sentinels, is becoming clearer, the impact of the adaptive immune system, specifically T cells is still unknown. A promising therapeutic strategy, would be to strengthen Aβ-induced regulatory T cells (Treg), to alter the effector T cell mediated inflammatory response, while promoting clearance of Aβ by microglia. My interdisciplinary project hosted by Trinity College Dublin and supervised by Prof Lynch will draw together both Neuroscience and Immunology. I propose to assess the effect of Aβ-specific Treg on the pathoethiology of AD. To this aim, I will amplify a population of Aβ-specific Treg in the APP/PS1 mouse model of AD and will 1) assess if Aβ-specific Treg can regulate instruction of microglia to clear cerebral Aβ, while keeping inflammation under control, 2) determine if this regulatory effect occurs via paracrine mechanisms from the periphery or if Treg physically enter the CNS and 3) identify other Aβ-specific T cell populations involved in response to cerebral Aβ build-up and in alteration of microglial phagocytic activity. Completion of this project will make a critical contribution to the understanding of the immune response in AD and will pave the way towards safer therapeutic tools. The proposed action will allow the dissemination of my work to both neuroscientists, immunologists, and the general public. I will reinforce my multidisciplinary and inter-sectoral skills, improve my management and teaching experience to establish myself among the leaders of research at ERC level.

Mots clés : neuroinflammation, microglia, regulatory t cells, cerebral amyloidosis, transgenic mouse model

Participants :
- Trinity College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187866.0 €
Projet IMAGINE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

With silicon-based electronics nearing its limits, spintronics and quantum computing have emerged as technologies promising unprecedented amounts of computational power. One of the biggest challenges in these fields is engineering of systems allowing full control over large arrays of identical spin-centres. In this project I aim to tackle this issue by fabricating a spintronic device in which one of the crucial parameters - the magnetic coupling between individual spin centres - can be efficiently modulated. This will be achieved by synthesizing a magnetic metal-organic network on top of a graphene field-effect transistor. Here, the metal-organic network allows precise positioning of magnetic atoms into long-range-ordered lattices, and the gated graphene substrate enables precise tuning of the charge transfer from the deposited molecules via the applied gate voltage. Thus, this project simultaneously addresses practical issues in device fabrication, as well as the fundamental mechanisms of magnetic coupling. Such a broad goal requires a concerted effort from researchers of different backgrounds. The shared expertise of the Host Group at the Central European Institute of Technology (CEITEC) and me is optimally suited for this project: I am experienced in atomically-resolved imaging, spectroscopy, and reactivity studies of both conductive and insulating systems. The Host Group has extensive experience with molecular self-assembly and graphene devices, and the Host Institution recently developed a novel state-of-the-art apparatus for Electron Spin Resonance Spectroscopy, a technique exquisitely sensitive for probing weak magnetic interactions. Overall, this project will provide fundamental insight into the characteristics of weak magnetic interactions, for which current literature provides many conflicting predictions. The resulting device will additionally serve as an ideal platform for further spintronic applications and quantum computing studies.

Mots clés : graphene, metal organic networks, self assembly, surfaces

Participants :
- Brno University of Technology (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 156980.64 €
Projet kANNa (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

With the growing popularity of herbal drugs an increasing number of scientific studies report information about herb-drug interactions that can significantly alter the effects of a drug. Keeping up with the current publication rate is not feasible, therefore there is a clear need for computational methods for early detection of herb-drug interactions that will enable better public and physician understanding of herbal products. But the costs of manually representing knowledge about herb-drug interactions in a machine processable way are prohibitive, therefore domain expertise has to be leveraged indirectly from domain-specific corpora using Information Extraction. This Marie Curie European Fellowship proposes a Deep Learning approach based on Artificial Neural Networks (ANN) and Information Extraction to monitor medical literature and construct a knowledge base of herb-drug interactions together with supporting evidence in the form of interaction mechanisms. To cope with the problem of incorrect or missing information we will consolidate the resulting knowledge graph using knowledge graph completion that predicts the probability of existence or correctness of typed edges in the graph. Advanced graph visualization techniques will be employed to develop intuitive interfaces for analyzing and comparing herb-drug interactions and underlying mechanisms. The Fellowship is expected to increase knowledge on clinically significant herb-drug interactions which will contribute to improved public safety. The Host will provide training on Deep Learning approaches for knowledge extraction which will open opportunities for a senior researcher position, in turn the Fellow will transfer Natural Language Processing skills and European collaborations to the host.

Mots clés : artificial neural networks, deep learning, biomedical informatics, herb drug interactions, semantic web, graph vizualization

Participants :
- Université de Bordeaux (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet MOIPB (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

With the progress of biological investigation, there comes a strong wish or need for imaging biological samples with multi-modality and on different scales. To meet this need, this project will develop a multi-modal 3D optical imaging platform that images on the multi-scale, from tissues to molecules, by integrating optical coherence tomography (OCT), stimulated emission depletion microscopy (STED), and fluorescence correlation spectroscopy (FCS). Incorporation of structured illumination, adaptive optics and focused engineering will improve spatial resolution, imaging depth, and molecular concentration sensitivity. The investigated technique will be tested and applied to biology investigation, including but not limited to, tissue and cell recovery in the Zebrafish (as a model organism) after laser damage. The multi-scale structural and functional image, as well as the dynamics on the protein level provided by this investigation, will potentially reveal tissue and cell recovery mechanisms, and in the long run contribute to the cure of disease along with understanding the mechanisms of tissue damage. This project will advance the state-of-the-art in optical imaging, and create new links between basic research and biological and clinical applications.

Mots clés : super resolution imaging, multi modal imaging, sted

Participants :
- University of Manchester (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet VISIONS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

With the rapid development of urbanization and continuous increase of vehicles on roadways, Intelligent Transportation Systems (ITS) play a key role in revolutionizing the way people commute. To make our cities safer and smarter, real-time traffic monitoring systems are deployed to help operators with observing traffic flows and identifying emergency situations. This project aims to achieve real-time traffic monitoring with high-quality video transmission in smart cities, leveraging the emerging Artificial Intelligence methods in video processing and video streaming. Firstly, the features of human visual systems will be referred on video quality allocation to reduce the required bandwidth for video transmission. Next, an innovative method for end-to-end video processing based on Deep Neural Networks will be developed to allow the video rendering and streaming at a lower resolution and also restore/improve the quality at the user ends. Finally, a new bitrate adaption scheme based on Reinforcement Learning will be designed to accommodate the unexpected network dynamics, guaranteeing the Quality-of-Experience to be perceived by users. The expected outcome can promote safer and more efficient travel for millions of users in Europe and billions of users all over the world. Moreover, the results of this project can be used in other multimedia applications, such as cloud virtual reality, distance education, smart transportation, and healthcare where video processing and video streaming are needed. To broaden the fellow’s knowledge horizon, a series of research, training, and knowledge transfer activities are planned. The new knowledge and skills imparted in these activities will further promote his academic portfolio and significantly enhance his career prosperity. The project will also play a solid foundation for the long-term and wide-range collaborations and eventually lead to more extensive impact of project results, from which both EU and China will benefit.

Mots clés : multimedia, traffic monitoring, video processing, video streaming, machine learning

Participants :
- University of Exeter (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet Brainwaves (Horizon 2020, appel à projets 2016)
Action : European Researchers' Night
Statut du projet : CLOSED

With the slogan “Brainwaves” the Researchers’ Night in Trier – City Campus meets Illuminale– will be showing that science is for everyone. There is a researcher in all of us. You only need a clever mind and a lot of curiosity. Our aim is to organize a public event showing on the one hand the exciting, interesting side of science and on the other hand how science can improve the citizens' everyday life. Another main target is to enhance public recognition of researchers and their role in society. Practical results of research will be delivered in a comprehensive and illustrative form, showing that science is all around us. To simulate everyday life situations the City Campus is grouped into seven Science Sceneries in the heart of the City. In these Sceneries different research presentation formats will be organized, using new formats of knowledge transfer. To bring science and researchers into peoples’ everyday life, the Sceneries will take place in unusual settings representing peoples’ normal life, e.g. the Science market place with Stage and European Corner, the Scientific Theatre and the area “Science goes to school”. The City Campus program includes hands on experiments and demonstrations, shows, contests, quizzes, exhibitions and much more. A significant number of researchers will participate in public events to interact face-to-face with the public. The visitors – mobilized through an extensive awareness campaign – will be given the chance to touch, feel and smell science. To increase the attractiveness the effective event Illuminale will be integrated in the European Researchers’ Night. Artistic illuminations of buildings and places will be combined with interesting spotlights on several areas of research. These spotlights are a metaphor for science and knowledge. Partners are the Trier University of Applied Sciences, the ttm trier Tourismus & Marketing GmbH and the Municipality of Trier.

Mots clés : researchers  night, city campus, research, innovation, science sceneries, research career, knowledge transfer, experiment

Participants :
- University of Trier (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171000.0 €
Projet S-PSK-PSK-MJ-PSC (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Within recent years, metal halide perovskite solar cells (PSCs) attracted enormous attention in research and industries as a future sustainable technology to harvest solar energy at very low cost. The material has demonstrated outstanding optoelectronic properties as well as the tunability of the perovskite bandgap over a wide range of energies by compositional engineering of the crystal structure. These properties enable Perovskite-Perovskite multijunction solar cells, which can harvest a wide range of the sun spectrum at very high efficiencies. The technology combines a high bandgap with a low bandgap perovskite absorber layer and offers the prospects of becoming a fully printable, low-cost and very high efficient thin-film photovoltaic technology. However, up to date, this technology is limited by the low performance and the instabilities of low bandgap (LBG) PSCs. In this project, this key challenge will be tackled by engineering LBG perovskites, both in the 2D as well as the 3D crystal structures, to reach a stable perovskite material of high optoelectronic quality. The ultimate goal is to develop efficient and stable LBG PSCs which will enable a Perovskite-Perovskite multijunction solar cell with power conversion efficiency (PCE) of >27% and >100 hours of stable power output. This will be a major landmark in the development of the photovoltaic technology and also, this fellowship would be an outstanding opportunity to me to promote my knowledge in the photovoltaic science and technology in an experienced and professional center.

Mots clés : low band gap perovskite, perovskite solar cells, perovskte perovskite multijunction, stability, high efficiency

Participants :
- Karlsruhe Institute of Technology (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 174806.4 €
Projet REPLICHROM4D (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Within the nucleus of eukaryotic cells, chromatin organization has emerged to be a major regulator of genome function. The question of how chromatin is shaped and maintained through DNA replication is key to understanding its impact. Distinct histone variants, modifications and binding partners are linked to specific structural and functional domains and might constitute a stable epigenetic signature. However, the passage of the replication fork disrupts parental nucleosomes and challenges existing patterns throughout the genome. Chromatin dynamics during DNA replication have not been characterized at genome-wide resolution. I aim to address this by tracking the deposition of the histone variants H3.1 and H3.3 along S phase. H3.1 and H3.3 are deposited via distinct DNA synthesis-coupled and -uncoupled pathways and, in asynchronous cells, show opposite genomic profiles that correlate with replication timing. I will exploit new bulk- and single-cell assays to monitor their de novo assembly in synchronized cells. These will be used to characterize the deposition of newly synthesized H3.1 and H3.3 as replication progresses, and compare spatiotemporal patterns to their global distribution before S phase. My objective is to implement a comprehensive computational strategy to 1) resolve H3.1/H3.3 dynamics in cell populations and individual cells, 2) explore the determinants and impact of differentially enriched domains and 3) evaluate the effects of perturbations on the mitotic inheritance of epigenetic states. This will allow to elucidate how specific signatures are propagated through cell division and shed light on the role of H3 variants as potential carriers of epigenetic information.


Participants :
- Institut Curie (France) — Coordinator, beneficiary, Recherche, subvention : 173076.0 €
Projet hh (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Within two years of the discovery of a Higgs boson with a mass near 125 GeV, a set of properties measurements have confirmed, within current experimental/theory uncertainties, its Standard Model (SM) nature. Nevertheless, beyond the SM theories offer a rich phenomenology and exciting prospects for the discovery of New Physics in the Higgs sector. This project aims to observe physics beyond the SM in the Higgs boson sector through the search for Higgs boson, h pairs in the hh->γγb bbar channel, which benefits from the large h-> b bbar branching ratio, efficient diphoton trigger, low backgrounds and excellent diphoton invariant mass resolution. Both the resonant and non-resonant production are considered. To this end, the proton-proton collision data collected by the ATLAS experiment at a centre-of-mass energy of 13 TeV at the Large Hadron Collider over the next two years, will be used and are expected to amount to 70/fb. The proposal to search for anomalous Higgs boson production and for heavy resonant states decaying to hh is original, and innovative methods in all aspects of the project will be employed. The results of the project, which will provide new information on the h self-couplings and the production of new resonances decaying to hh, will be interpreted within various theoretical frameworks, with emphasis in two Higgs-doublet models.

Mots clés : atlas, standard model, new physics, higgs boson, photons, b quarks

Participants :
- University of Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €