Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CHILL (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This Action will produce a high-precision error detection computational system for Mandarin Chinese, which diagnoses the linguistic source of grammatical errors, and uses this information to provide corrective feedback to learners. The Action takes advantage of the Applicant’s expertise in computational linguistics & their educational applications and relies on supervisor’s expertise in Chinese syntax. The Action includes an in-depth syntactical analysis and computational implementation of both the structure of Mandarin Noun Phrases and related common errors. The focus will lie on quantification, reference/deixis, cognitive status and modification. The Action will make use of well-grounded data-driven interdisciplinary methodologies, integrating standard methodologies for formal linguistic analysis and methodologies for software development from the field of Computer Science. The supervisor and the Applicant have published together and collaborated successfully in other projects. The beneficiary, the Department of Asian Studies at Palacký University, has an excellent reputation in the field of Asian languages with a strong emphasis on new methods in language teaching. These conditions offer an optimal opportunity to develop and test the results of the proposed Action. Through the interaction with the supervisor and training-through-research, the Applicant will acquire expertise in Chinese Syntax. In addition, the beneficiary also offers state-of-the-art physical and technological infrastructure, including a Trainee Center with excellent opportunities to develop transferable skills. The training received through this Action will create valuable opportunities for the future career prospects of the Applicant, and help him fulfil his plan to establish an academic career in Europe.


Participants :
- Palacký University, Olomouc (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 144980.64 €
Projet CAR (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This European Fellowship project will benefit the researcher by giving and enhancing the knowledge and skills for a future generation of CPSs which enjoy the unique feature of context-active resilience. With such new capability and training, the researcher is expected to realise his potential and gain his leading role at international level in CPS research community. Context-active resilience is a novel concept of CPS resilience proposed in this action, which emphasises active and even proactive response to the dynamic state of CPS and its users in real-time. CAR Patterns will be identified via the empirical analysis of practical CPS systems, and specified with the developed Meta-Intelligence and populated into a semantic repository. Due to the wide and critical roles of CPS in industry and society and the novelty of context-active resilience, the proposal is both timely and significant. Acting as a bridge, the project will simultaneously advance the theoretic approach and art of practice of this emerging topic, improve the competency and career of the fellow, enhance and complement the host’s research profile and infrastructure, and benefit the society, living, economy and related research communities significantly.

Mots clés : context active resilience  car, car patterns, meta intelligence, semantic repository

Participants :
- Edinburgh Napier University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet AutoStopS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This Horizon2020 – Marie Sklodowska Curie Actions – Individual Fellowship grant proposal focuses on the development of a new gene therapy approach targeting intractable epilepsy, with the major aim to achieve autoregulation of seizure detection and termination. For this purpose, a glutamate-gated chloride channel (GluCl; cloned from C. elegans) will be expressed in excitatory neurons in the rodent brain using a viral vector and a human CamKIIα promoter. In response to increased glutamate levels, as present during epileptic seizures, the channel activates and opens a Cl- conductance. This, in turn, inhibits excitatory neurons and causes seizure suppression. As a further advantage, an “add-on” therapeutic approach with the GluCl agonist ivermectin, an approved antihelminthic drug, is available. In principle, the gene therapy could therefore confer both an autoregulatory effect to the transduced brain region and have an external “gain control” exerted by pharmacological modulation. Taken together, my Fellowship proposal aims to develop a radically new antiepileptic strategy to treat drug-resistant, refractory epilepsy, which affects approximately 1 million people in Europe.


Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 137591.1 €
Projet SIMULTANEOUS DBTMI (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

This MSCA is designed to support Dr. Predrag Bakic in his professional development and reintegration into European research community, after he obtained Ph.D. and spent 12 years as a faculty in USA. The host institution, Lund University (LU), is one of the largest in Sweden and among the most prestigious in Europe. Dr. Bakic and his LU supervisors, Dr. Sophia Zackrisson and Dr. Anders Tingberg, share the research focus in breast imaging, with unique complementary expertise: Dr. Bakic in Virtual Clinical Trials (VCTs) based upon the simulation of breast anatomy and imaging systems, and LU team in Mechanical Imaging (MI) and conducting clinical trials of breast imaging. Our action is motivated by a persistent challenge of underdiagnosis and false positives in breast cancer healthcare. The four most exciting innovations in breast cancer imaging that have recently emerged include: Digital Breast Tomosynthesis (DBT), MI, VCTs, and artificial intelligence (AI). In this application we will utilize extensive experience of LU and Dr. Bakic to interconnect these innovations efficiently and flexibly, enabling significant benefits. Within the two-year timeline, we will design and build a simultaneous DBT and MI (termed DBTMI) prototype system, and develop image processing and DBT reconstruction to maximize image quality. We will evaluate the prototype, first preclinically by VCTs and physical phantoms, followed by a pilot co-clinical trial (which combines clinical and simulated data). We will also explore introducing modern AI methods, in the form of Deep Learning Networks (DLN) to improve DBTMI performance. DLN has demonstrated ability to discover complex correlations in clinical images, leading to superior detection and classification of clinical findings. Combined complementary experience, carefully designed knowledge-exchange activities, and LU excellent institutional resources, guarantee the success of this application, and Dr. Bakic's successful reintegration.

Mots clés : breast cancer screening, mammography, digital breast tomosynthesis, mechanical imaging, computer, simulation, virtual trials, underdiagnosis, false positives

Participants :
- Lund University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203852.16 €
Projet BioCore VIP (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This Marie Sklodowska Curie Individual Fellowship will bring an outstanding experienced researcher to work in Europe and be mentored by a world leading expert in low energy building technologies. Over the past 20 years, the Incoming Research Fellow, Prof Fatang Jiang has specialised in biodegradable materials and been an active technology entrepreneur by successfully commercialising his research outcomes including polysaccharide sponges and aerogels, edible desiccants, biodegradable and structure controllable superabsorbents for water retention, and innovative water activity measurement. The proposed project has been carefully chosen to match the researcher's experience in bio-sources materials with the host scientists’ expertise in low energy building technologies to produce some innovative outcomes and create new benefits to the society in Europe. The project aims to develop an environmentally-friendly bio-sources aerogel as the support core for vacuum insulation panels (BioCore VIP). Thermal insulation is a primary approach to reduce the buildings’ energy demand. Aerogel, particularly encapsulated in vacuum panel with a multilayer film, is a super insulation material with an extremely low thermal conductivity and hence can obtain the required thermal resistance with a very small thickness, which is desirable commercially in order to minimise the effect of insulation on the building usable space. Development of the proposed aerogel requires comprehensive scientific knowledge including material preparation, freeze-drying, heat transfer and buildings’ energy analysis. Combination of the expertise between the Incoming Researcher and the host team matches this requirement perfectly. In addition to the scientific goals, the Incoming Researcher will contribute his expertise on polysaccharide aerogel and soil water retention to provide training for researchers, students and industrial contacts by hosting seminars, giving lectures and participating in outreach activities.

Mots clés : polysaccharide aerogel, biodegradable, hydrophobic modification, structure controllable, thermal insulation, vacuum insulation panel  vip

Participants :
- University of Nottingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet WiseCure (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This WiseCure Fellowship aims to bring novel wireless, scalable, MRI-compatible, and bio-integrated neural implants for optogenetics to treat epilepsy. Neurological diseases such as epilepsy is a life-threatening progressive disorder causing uncontrolled activity of the brain (seizure). The ability to decipher brain functions and understand the neuronal communication networking properties to develop innovative solutions to treat neurological diseases remains one of the biggest challenges to date. A recent approach to study the brain is optogenetics. Optogenetics is a neural modulation technique which utilizes light to stimulate genetically engineered neurons, providing a better option for controlling the cells compared to conventional electrical stimulation. Scientists pursuing optogenetic therapies still face some technical challenges (e.g. size and multifunctional capability, biointegration, wireless capability, Magnetic Resonance Imaging (MRI) compatibility) that keeping optogenetics from clinical trials for brain diseases. I will combine the innovative wireless power transfer (WPT) approaches with ultrathin, soft and flexible biocompatible polymeric platforms to fabricate and characterize neural implants that are small enough to promote scalability, chronic reliability, and MRI compatibility. By associating the ability to wirelessly monitor (e.g. neural activities) and control (stimulation or inhibition) through these neural implants using a smartphone establishes a novel approach for versatile optogenetics to treat epilepsy. This Fellowship will act as a platform to realize my futuristic vision by integrating the wireless optogenetics system into smart healthcare using mobile and electronic technology for better diagnosis of the brain diseases, improved treatment of the patients, and enhanced quality of lives.

Mots clés : metamaterials, biointegration, wireless neural interface

Participants :
- University of Glasgow (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet BirthControlEnvirons (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This action aims to conduct research among young women who are both feminists and environmentalists, and study how they negotiate these sensibilities in their striving for chemical-free contraception. Field research will be carried out in France, a place where on the one hand environmentalism is characterized by a strong concern with toxic chemicals in everyday life and, on the other, where access to the contraceptive pill remains an emblematic victory of second wave feminism, and by far the most prescribed contraceptive method nationwide. Theoretically, this project will contribute to the anthropology of chemicals, an emergent and cutting-edge subfield of research, and to the growing public debate regarding the ‘crisis’ of the contraceptive pill. Findings will be disseminated through seminars and publications that help push the boundaries of the discipline, a short documentary film that will appeal to wider audiences, and a few, carefully designed interdisciplinary activities that will bridge the domains of academia, arts, activism, and policy.

Mots clés : environment, feminism, synthetic hormones, toxicants, france

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 184707.84 €
Projet TaGFrag (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

This action aims to discover novel, synthetically tractable small-molecule stabilisers of the therapeutically important 14-3-3δ – estrogen receptor alpha (ERα) protein-protein interaction (PPI). To achieve this a rational target-guided chemical biology approach will be developed that combines the concepts of fragment-based drug discovery with bioorthogonal synthesis. The significances of achieving this aim are two-fold. First, it would provide valuable tool or lead compounds to aid the maturation of this interaction as a clinical target. Secondly, it would provide a rational and efficient approach for the discovery of PPI stabilisers in general. This under-explored area of pharmaceutical research has the potential to deliver new medicines for the treatment of diseases such as cancer which pose a major societal challenge in Europe. The project will combine the powerful tools of synthetic chemistry, biophysical assay techniques and protein crystallography in the true ethos of chemical biology for drug discovery. It will provide the Fellow with excellent experimental training in this increasingly important field, complimenting his proven track-record in synthetic organic chemistry research. Therefore this proposal seeks support to embark on an innovative, integrated and multidisciplinary programme of research which will allow for the consolidation and expansion of the experiences gained by the Fellow during his brief tenure at the ideally suited Laboratory of Chemical Biology, the Technical University of Eindhoven (TU/e). This Fellowship is a crucial opportunity to enhance the Fellow’s creative and innovative potential thus allowing him to establish an independent research career at the interface of synthetic chemistry and the study of biological systems.

Mots clés : rational design, fragments, synthesis, bioorthogonal reactions, protein crystallography, biophysical analysis

Participants :
- Eindhoven University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet CHAP (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This action proposes mobility for an Italian researcher living in Britain to work in Ireland on a transnational historico-literary project. Her research focuses on the cross-cultural transfer of cheap print between Britain and Italy in the first half of the nineteenth century. The project advances existing knowledge of popular publishing and reading in two ways. Firstly, it contributes to the European historiography of cheap publications by extending the investigation of their production, distribution and reception to the Italian context. Secondly, and most importantly, it provides a concrete idea of the cross-cultural nature of cheap literature by exploring the mechanisms which regulate its migration from one linguistic and cultural realm to another. The transnational trajectory of cheap print is investigated with a focus on translation and on its potential to establish fruitful negotiations between the literary and cultural repertoires of the source and the target context. The project examines a corpus of chapbooks translated from English into Italian published between 1800 and 1850. The Italian chapbooks and their sources are analysed using an interdisciplinary approach which integrates theories of textuality, the history of the book and of reading, and translation studies. The comparative approach followed in my study will significantly enhance our understanding of popular literature and of the processes which led to the formation of a shared European heritage of popular culture. The multidisciplinary research environment at NUIG provides the ideal conditions for the researcher to develop this project and the skills necessary for her future academic career. The collaboration of Dr Niall Ó Ciosáin and the training that she will undertake in the history of the book will be particularly important to integrate her familiarity with translation and the eighteenth- and nineteenth-century Italian cultural context with new knowledge of popular publishing and reading.

Mots clés : cross cultural mobility, cheap print, popular culture, translation, literary heritage

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet MIDxPRO (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This action proposes to carry out research in open ended contact probe (OECP) technique to lay out foundation work for development of two new applications: an automated surgical margin detection device for breast cancer treatment and an automated microwave biopsy probe for breast cancer diagnosis. While the envisioned applications require a single and highly accurate measurement, OECP technique suffers from high error and low repeatability dielectric property measurements. The error mostly stems from the current mathematical approach utilized for the dielectric property retrieval which may converge to local minimum and can magnify the measurement set-up based errors. This research will first target the existing error by proposing robust mathematical retrieval approaches. Next, application based modifications will be investigated with new probe structures. Finally, further error minimization will be achieved by introducing classification algorithms. Developed techniques will be validated with animal experiments. The outcomes of this research will greatly contribute to the innovation of new medical devices that can be utilized for breast cancer, representing one of the most commonly diagnosed cancer type among women. The researcher is well-equipped and has the required capabilities to execute the objectives of this research. The host organization and supervisors have an extensive track record in medical device development, necessary infrastructure, network, and expertise. This research will allow the researcher to become independent by extending her network, publication/grant track record, skill sets, and more importantly, through joining an innovation oriented host organization, the researcher will gain expertise in phases that enables the research to be transformed into innovation. Finally, the goal of the proposed research, building the foundation for innovation, is also in line with ‘Future and Emerging Technologies’ call of the H2020 work program.

Mots clés : dielectric properties of biological tissues, open ended coaxial probe technique, breast cancer diagnosis, machine learning, inverse problems, dielectric spectroscopy, rat experiments

Participants :
- Istanbul Technical University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 157845.6 €
Projet EPPIC (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

This action, “Emitter-mediated Photon-Phonon InteraCtion” (EPPIC), will contribute to the research areas of quantum computing and quantum sensors. These are key areas of the quantum technologies flagship initiative, which has the goal of establishing Europe as a leader in the second quantum revolution and its future industrial exploitation. The focus of EPPIC is on III-V semiconductors due to their compatibility with industrial nanofabrication. Implementing quantum bits in such semiconductors typically relies on the optical control of single spins in local potential traps (expertise of the host). These traps are called quantum dots (QDs). In order to carry out computations using QDs their behavior needs to be well controlled. Continuous interactions with an uncontrolled environment have a “distracting” influence on the QD and lead to a phenomenon known as decoherence. Overcoming decoherence is a major challenge in developing quantum technologies. In this action novel optomechanical and purely mechanical nanostructures will be designed and realized in order to shield QDs from some of the light (optics) and sound (mechanics) in their environment (expertise of the applicant). Once achieved, resonators can be designed that make the QDs interact strongly with specific frequencies of light and sound. The aim of EPPIC is to demonstrate that these nanostructures can manipulate the optical and spin-dynamics of a QD and that optical control of the QD can be used to manipulate the state of an isolated mechanical resonator. These accomplishments will lay the ground work for future projects: to create nonlinear elements for optomechanics; mediated QD-QD interaction by a common mechanical mode; achieve ground-state cooling of a mechanical resonator via optical control of a single QD; and using the optical control of QDs to prepare non-classical mechanical states. Thus giving the applicant an excellent starting point to conduct high-impact research in his future scientific career.

Mots clés : quantum dots, optomechanical and mechanical crystals, spin dynamics, resolved sideband regime, photon phonon interaction, and quantum acoustics

Participants :
- University of Basel (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175419.6 €