Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet QuatSalts (Horizon 2020, appel à projets 2015)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : CLOSED

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to develop three new categories of quaternary ammonium salts to be used as catalysts for the cost-efficient and green manufacture of high value active pharmaceutical ingredients. In order to achieve this objective the proposal brings together 3 partners with complementary skills: University of Naples(UNIN): experts in the preparation and purification of cyclic peptides. Experts in solid phase synthesis and immobilisation of peptides on solid support. KelAda Pharmachem: Phase transfer catalysis/organo catalysis/scale-up of chemical processes University of Linz(JKU Linz): experts in design of new ammonium salts and optimisation of enantioselective phase transfer catalyses. We have broken this proposal into the following separate Work Packages: WP1. Preparation of new designer ammonium salts [WP leader: Kelada] WP2. Preparation of cyclic peptide based ammonium salts [WP leader: UNINA] WP3. Evaluation of new ammonium salt catalysts prepared through WP1 [WP JKULinz] WP4. Evaluation of new Ammonium salt catalysts prepared through WP2[WP leader: UNINA] WP5. Application of Ammonium salts to drug production [WP leader: Kelada] WP6. Scale up of key steps or the manufacture of drugs [WP leader: Kelada] WP 7. Management, Communication & Dissemination [WP leader: KelAda] The above WP’s will be undertaken via a series of interlinked secondment of researchers between consortium partners and will be complemented by a series of training and other initiatives to facilitate interdisciplinary and intersectoral knowledge sharing and exchange.

Mots clés : phase transfer catalysis, cyclic peptides

Participants :
- Kelada Pharmachem (Ireland) (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 180000.0 €
- Johannes Kepler University of Linz (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 162000.0 €
- University of Naples Federico II (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 432000.0 €
Projet PUSKURUM (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The aim of this project is to differentiate and characterize the pyroclastic products from explosive eruptions produced by Açigöl caldera, Hasandağ, and Erciyes stratovolcanoes, which are the most active and largest volcanic structures of the central Anatolian peninsula. This study is necessary to complete the gap in the tephrostratigraphic framework of the easternmost part of Europe and to reconstruct the explosive volcanic history of the region during the upper Pleistocene – Holocene, and therefore, better assess the currently volcanic hazards posed by these volcanoes on the region. The main proximal pyroclastic units of the Central Anatolian Volcanic Province (CAVP) will be identified, mapped, logged, and sampled around major volcanoes. Afterward, their chemical composition and eruption ages will be determined in the laboratory to correlate them to tephra layers deposited in distal records (including sedimentary or paleoclimatic registers). Despite an increasing number of recent studies identified many fine volcanic ash layers that are thought to be from large eruptions of Central Anatolian active volcanoes (e.g. in cores from the Black Sea, Eastern Mediterranean Sea, caves in Egypt, or several small Romanian lakes), little is known about the spatial and temporal scale of explosive volcanism in Turkey. Correlation of these tephra layers by chemical fingerprint is essential to 1) synchronize records and identify their position in high-resolution palaeoenvironmental or archaeological registers, 2) estimate the volume and magnitude of the related eruptions, and 3) determinate how past explosive eruptions could affect the region and its occupants. Such tephrochronologic studies are important to improve our understanding of Anatolian volcanism and to more accurately constrain the hazards that the active volcanoes of CAVP pose to the often-large populations surrounding them (e.g. the 1.3 million people of Kayseri city).

Mots clés : geological mapping, tephrostratigraphy, central anatolian volcanic province, glass chemical fingerprint, rediogenic datings  c14, th and ar, volcanic hazard assessment, paleoenvironmental record

Participants :
- Sapienza University of Rome (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183473.28 €
Projet Halo (Horizon 2020, appel à projets 2016)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : CLOSED

The aim of this project is to expand upon a newly discovered platform reaction by developing new routes to Active Pharmaceutical Ingredients (APIs) Tolterodine and Ezetimibe and other advanced intermediates for the manufacture of drugs (i.e. benzylic fluorides and alcohols). It is planned that this platform will serve to enhance the competitveness of the European pharmaceutical manufacturing industry as it continues to face increased competition from other economies In order to achieve this aim we need to bring together expertise in (i) Organic Synthesis [Royal College of Surgeons in Ireland, “RCSI”] (ii) Enantioselective fluorination [Nagoya University Japan, “Nagoya”] (iii) Drug development and production [Integrated Research in Biotechnology & Medicine, “IRBM”] To meet the aim we have divided the project into the following work packages: WP1: Development of a new synthesis of Tolterodine. WP2: Scale up of synthesis of Tolterodine. WP3: Development of a new synthesis of Ezetimibe. WP4: Scale up of synthesis of Ezetimibe. WP5: Exemplification of alkoxylation to prepare enantiopure benzylic alcohols API intermediates WP6: Preparation of benzylic fluorides WP7: Management, Training, Dissemination & Communication

Mots clés : halogenation, fluorination

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 130500.0 €
- Nagoya Institute of Technology (Japon) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Destina genomica slne (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 81000.0 €
- IRBM Science Park (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 81000.0 €
Projet CVD in RA (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The aim of this project is to uncover the mechanisms by which patients with rheumatoid arthritis (RA) may have an elevated risk of cardiovascular complications. In particular, we will determine the role of the inflamed joint microenvironment in promoting cellular bioenergetics of cardiomyocytes. We aim to test the hypothesis that cardiomyocytes of RA patients reflect the features of pathological changes that might indicate for the cardiac vulnerability characteristic for this disease. This proposal has three specific objectives: (1) To examine whether exposure of control and RA-specific induced pluripotent stem cells-derived cardiomyocytes (RA-iPSC-CMs) into a joint-like environment recapitulate a cardiac disease-like state; (2) to determine the effect of a joint-like environment on cellular bioenergetics of control and RA-iPSC-derived CMs; and (3) to test whether control and RA-iPSC-CMs can act as a tool to identify potential cardioprotective/cardiotoxic treatment strategies used in RA. This project proposes a truly translational, bench-to-bedside approach building on the strength of the human RA model. We will establish a unique source of functional cardiomyocytes by reprogramming RA synovial fibroblasts and peripheral blood mononuclear cells to iPSC. To investigate the impact of the joint inflammation on cardiomyocytes’ bioenergetics and transcriptomic profile, the state-of-the-art technologies will be applied. The most advanced cell metabolism analyser will be used to quantify real-time measurements of mitochondrial respiration and glycolysis. Global analysis of mRNA and miRNA transcriptome by RNA-seq will allow identifying new cardiomyocyte-specific genes/pathways that might affect cellular metabolism in RA. Using iPSC-CMs will provide a unique opportunity to examine the pathophysiology of cardiac involvement in RA and to evaluate whether they may serve as a preclinical platform for precision medicine.

Mots clés : rheumatoid arthritis, cardiomyocytes, ipscs technology, mitochondrial dysfunctions

Participants :
- Jagiellonian University (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 149625.6 €
- Kardio-Med Silesia (Pologne) — Partner, beneficiary, Recherche, subvention : 0.0 €
Projet AnNuVitE (Horizon 2020, appel à projets 2017)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : SIGNED

The aim of this project is to use exchange of staff on an international and inter-sectoral basis to investigate the impact of consumption of novel nature-identical RRR-α-tocopherol in animal models on nutritional quality of animal-derived foods and in human models on bioavailability and circulating stereoisomers, and in doing so to foster a culture of research and innovation that will underpin new innovative products, services and processes in the area of animal and human nutrition. Vitamin E is represented by a suite of 8 compounds – 4 tocopherols (α, β, γ, δ) and 4 tocotrienols (α, β, γ, δ). The main function of vitamin E is as an anti-oxidant, preventing free radical-mediated lipid oxidation, particularly of membranal lipids. α-Tocopherol is the most biologically active form but α-tocopherol itself exists in 8 stereoisomeric forms arising from the 3 chiral centres it contains, RRR, RRS, RSR, RSS, SSS, SSR, SRS and SRR. Of these RRR-α-tocopherol is the most biologically active form.

Mots clés : vitamin e, food trials, animal studies

Participants :
- Devenish nutrition ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 216000.0 €
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162000.0 €
- Oregon State University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ICARUS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The aim of this proposal is to study quantum dynamics in the presence of disorder, and specifically the Anderson and many-body localization transition to a phase where transport and thermalization are absent. Localization in quantum systems has both deep fundamental implications in many different fields and exciting practical applications in quantum technology. In this action the researcher, who is experienced in the statistical physics of quantum disordered systems, will address in a novel and timely way this topic. She aims to improve understanding of it with a three-fold approach: a quantum information experimental effort; new theoretical tools coming from the study of random matrices and the physics of glassy systems; and a joint work with a non-academic entity on numerical methods that use artificial neural networks for the classification of the localized phase. She will perform this work in the perfectly suited environment of the Thermodynamics and Energetics of Quantum Systems research group at Trinity College Dublin.

Mots clés : many body localization, quantum information, jamming transition, random matrix theory, neural networks

Participants :
- Trinity College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184590.72 €
Projet VGAP (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The aim of this study is to analyze the comprehensive proteome associated with viral DNA. This systems biology approach that will combine functional proteomics and genomics has the name Viral Genome Associated Proteome (VGAP). It is based on a modification and refinement of the Hybridization Capture of Chromatin Associated Proteins for Proteomics (HyCCAPP) technology. All proteins associated with viral DNA, initially using Herpes simplex virus for proof of concept, will be cross-linked by paraformaldehyde treatment, the viral DNA will be selectively precipitated, and all proteins associated with the viral genome will be analyzed by mass spectrometry. The results will reveal all cellular and viral proteins that physically interact with the viral genome at a certain time and that are involved among others in regulation of viral genome structure, viral gene expression, DNA repair and cellular intrinsic immunity. The development of VGAP, a new method for the specific analysis of the viral genome-associated proteome will provide a new tool for the research of DNA viruses. In theory VGAP should be applicable to all DNA viruses, and we think it will be possible to analyze proteins associated with the DNA of all DNA viruses, so the entire field of virology should profit from the establishment of viral HyCCAPP. DNA viruses include important human pathogens like herpesviruses, human papillomaviruses and adenoviruses. A plethora of novel viral DNA-protein interactions will be discovered that will spark new research projects and can serve as new targets for antiviral therapy and vaccination strategies. Although beyond the scope of this proposal, so far unknown cellular proteins that are needed for efficient viral replication can be used for screening of small molecule libraries and novel small molecule inhibitors identified for antiviral therapy.

Mots clés : herpesviruses, dna damage response, dna binding proteins, innate immunity, restriction factors

Participants :
- Universitätsklinikum Erlangen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171460.8 €
Projet POLIS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The anaerobic ammonium oxidation (anammox) is an innovative technology for the removal of nitrogen from wastewater (ww) saving 60% of aeration and 100% of organic carbon. Its potential application to municipal ww allow a complete redesign of the present energy-consuming into an energy-yielding ww treatment plant. Due to the slow growth rate of anammox bacteria, their retention in the system, and therefore granule stability, is the main concern of this process. Granular stability is closely related to the properties of their exopolysaccharides (PS) and their interactions with proteins and mono-divalent cations. In the proposed research integrated analytical methods (UV-visible, FT-IR, MALDI-TOF MS, NMR, (pyrolysis)GC-MS, HPLC) will be used to investigate functional PS and their fine structures, unrevealing the mechanisms involved in anammox granular sludge formation and stability. Modern rheological (AOS, LLCT and Microrheology combined with CLSM), light scattering (DLS, SLS) and microscopy techniques (AFM, FT-IR, CLSM) will be used to investigate their interactions with proteins and cations. PS will be isolated from lab- and full-scale reactors. The definition of standardized extraction (loosely/tightly bound-EPS, LB/TB-EPS) and analytical methods will bridge the existing gap for efficient and meaningful comparison of the results from this and future research. The methods set up here, will largely contribute to increase the scientific significance of PS studies in anammox granular sludge area as well as facilitate the entire biofilm research field. Studies on biofouling and biocorrosion will also benefit from the high-quality of the information and basic knowledge acquired. This research will strengthen the EU leadership in anammox granular sludge technology also improving EU scientific excellence in PS research area and provides the researcher an advanced level of multidisciplinary training, opening concrete perspectives for his career development.

Mots clés : anammox, granular sludge, biofilm, exopolymeric substances, exopolysaccharides, rheology, exopolymeric proteins, mono divalent cations

Participants :
- Politecnico di Milano (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 168277.2 €
Projet PARCA (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The analysis of archaeological textiles is a challenging undertaking. These precious remains have been altered to the point that discerning their composition requires the development of high specialised analytical tools, characterized by high sensitivity and great versatility. In different sites, many textiles have been excavated, some well-preserved, some with signs of carbonisation; in some cases, traces of colour are still visible. PARCA project proposes to join forces between dye analysis and proteomics to develop an innovative streamlined protocol that would combine dye and protein analysis in a single extraction to minimise sampling size while maximising the amount of information obtained. It will be achieved through the most up-to-date methodologies and instrumental developments of Liquid Chromatography-Orbitrap-Mass Spectrometry to develop protocols that will be applicable to the most degraded archaeological textiles. The LC-MS data will be correlated with FTIR and SEM analyses, to determine the threshold of protein survival by non-destructive techniques prior to proteomics. The project will be carried out for the first 2 years at the Smithsonian Institution (Washington DC-USA), in the proteomics lab under the supervision of Dr. Caroline Solazzo. The third year, incoming phase, will be carried at Sapienza University of Rome, under the supervision of Prof. Roberta Curini. At the end, archaeological relics from the Mediterranean basin will be analysed, in particular samples from Pompeii and Vesuvian areas and from Greek areas. The success of this project will result in gaining new experience in the analytical characterization of ancient textiles, by enriching my background on dyes with the acquisition of a very high level of skills in the field of proteomics and in high resolution mass spectrometry. This knowledge will allow me to reach a leading profile as independent researcher and to strongly strengthen my position in the field of Cultural Heritage Science.

Mots clés : proteomics, dyes, cultural heritage, new methodology, extraction protocol, mass spectrometry, textiles, archaeological textiles

Participants :
- Sapienza University of Rome (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269002.56 €
- Smithsonian Institution (Etats-Unis) — Partner, organization partner, Autres, subvention : 0.0 €
Projet Gm2m (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The anomalous magnetic moment of the muon has revealed its potential to be the cornerstone for beyond the Standard Model searches, since it is one of the most accurately measured quantity in particle physics. Being the Standard Model in a nutshell, is at the cutting edge of the developments in the field. A persistent discrepancy between theory and experiment exists and has triggered two new challenging and expensive experiments at FermiLab and at JPARC which will push the measurement of that quantity to an unprecedented precision of a 0.14 ppm. At that level, differences beyond theoretical uncertainties among theory collaborations are limiting the theory precision. Thus, they must be resolved with an exceptional precision as well to sort out whether the observed departure is and indication of New Physics and to correspond the enormous experimental effort. The project Gm2m aims to provide the theoretical framework to coordinate and elaborate on a continuous and robust update of the Standard Model prediction of this observable through the use of 1) a user-friendly and modern web-page interface that should allow the community to keep track of the exact state-of-the-art calculation and 2) a new reassessment with unparalleled precision of the uncertainties of the Standard Model. The project Gm2m will consider a set of novel approaches for finding a solution to the current theoretical puzzles, which also demands an exhaustive scrutiny of the theoretical uncertainties at the 0.1ppm level. This effort should culminate in a most robust Standard Model prediction up to date. The project Gm2m will become a milestone for particle physics and anticipates a long-lasting impact for the society thanks to an ambitious dissemination plan.

Mots clés : precision observables, standard model calculations, new physics benchmark

Participants :
- National Institute for Nuclear Physics (Italie) — Coordinator, beneficiary, Recherche, subvention : 180277.2 €
Projet FIDELITY (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The application for a Marie Curie IF covers the personal development of the ER by providing the steps necessary to establish an independent researcher status by the end of the fellowship. The main vehicle for this is a program of novel research that develops the experience already gained in the experimental and computational solid mechanics and materials characterization. The IF proposal builds on the expertise at the University of Southampton, where the ER will be based. The research covers the development of understanding and accrual of knowledge on the behaviour of fibre reinforced polymer (FRP) composite materials, which are crucial to address current need to produce lighter, more fuel efficient and sustainable structures for transportation. The mechanical behaviour of FRP is strain-rate dependent and a full understanding of this behavior has proved elusive. There are numerous engineering applications where high strain rate impact damage can lead to loss of structural integrity, so obtaining a better understanding this behaviour is essential for efficient design. New full-eld imaging approaches are increasingly used for the detection and analysis of damage in composites. The objective of the research program is to develop and verify a new methodology where integrated thermomechanical full-field high fidelity measures of stress and strain are provided experimentally. The research will for the first time provide quantitative inputs to models to inform designs and predict failure under high strain rate events through and experimentally derived damage index to determine structural performance. The fellowship contains significant technology transfer through industrial collaborations and secondment to industry. The industrial interactions will enable the methodology to be applied at a structural scale and bring about a key element on the pathway to revolutionise traditional approaches to structural testing, certification and validation.

Mots clés : instrumentation, metrology, thermography, composites

Participants :
- University of Bristol (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €