Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet FISM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project aims to be the first attempt at investigating the forms, uses and functions of Hindi contemporary humour (hasya) and satire (vyangya). By moving towards this direction, it will focus especially on the connection of Hindi satire with the claims by the subaltern and marginalized subjects and communities of Hindi contemporary public sphere. It must be outlined that the terms subaltern and marginalized will refer not only to the Adivasi - framed by Indian constitution as the 'tribals' of India - and to the Dalit - better known as the 'outcaste' people - but also to the LGBTQIA+ and to the discriminated women in India. In the light of the above, the main objective of the research is to shed light on the narratives of dissent pursued by these subjects and communities. It will also analyse the contribution of Hindi satirists and humourists to specific socio-cultural and political claims and initiatives. Finally, it will investigate the use of satire and humour as a personal and collective forms of resilience. To achieve these set goals, the project surveys in a interdisciplinary way many fields in which satire can be detected. Primarily, it focuses on the use of satire in Hindi contemporary literature. In this field the research highlights the contribution of Surya Bala, usually deemed as the first Hindi woman literary satirist. Other less famous marginalized literary contemporary satirists will be equally taken into consideration. Moreover, it must be stressed that, apart from the literary side of satire, the project will investigate also the 'life' beyond literature of satire. In this field, it will focus primarily on the performative uses of satire and humour during the Hasya kavi sammelan (Meeting of humorist poets) which are usually held in many parts of North-India and the shows by stand-up comedians.Other less known performative uses of satire will be taken into consideration. The research will also outline the uses of satire and humour on new media.

Mots clés : hindi public sphere, marginalized subjects and communities, satirical activism, satire as performance, humour

Participants :
- Université de Rome « La Sapienza » (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230352.0 €
- University of Petroleum and Energy Studies (Inde) — Partner, associated partner, Autres, subvention : 0.0 €
Projet Mechano-Ageing (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

A recent work published by the host laboratory had redefined aging as a mechano-disease. Transcriptional co-factors YAP/TAZ, masters of mechanotransduction, were critical in stromal cells to prevent aging. Importantly, restoring cell-ECM communication and YAP/TAZ level was sufficient to "rejuvenate" old cells. Consequently, we hypothesize that the culprit of aging should be searched in ECM changes that drive the loss of mechanotransduction in stromal cells. Using single cell RNA-sequencing data of mouse dermal fibroblasts and mass-spec analyses of the dermis ECM during aging, we will seek for ECM candidates that may be at the root of this process. Then, we will build an Atlas of the mouse skin during aging using spatial transcriptomic and immunolabeling of mechanoresponsive proteins to unveiled new interconnections between the ECM and altered mechanotransduction during aging. As validation, we will use two complementary in vitro approaches. First, old mice fibroblasts will be culture on a young ECM synthetized by engineered young mice fibroblast lacking specific ECM genes, pinpointing to ECM proteins able to rejuvenate old cells. Second, we will generate 3D organotypic skin culture with keratinocytes and engineered dermal fibroblast lacking specific ECM candidate. We will ask whether it affects mechanosignaling and acquisition of aging traits in both dermis and epidermal compartments. Digging into the “mechanics of aging” is crucial because it would add a new paradigm on the causes of cell senescence and aging, define new markers for healthy aging and inform on new therapeutic perspectives to combat aging or some of its associated pathologies.

Mots clés : ageing, mechanobiology, mechanotransduction, extracellular matrix, mechanosensing, yap taz, single cell rna sequencing, spatial transcriptomics, in vitro 3d model, crispr cas9 technology

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet ENCHANT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Quantum computing is a very rapidly developing field with the potential to address problems that were considered intractable some decades ago. Despite the daunting technological challenge, quantum devices have reached a size for which their calculations cannot be fully simulated by classical computers. Nevertheless, noise and short coherence times hinder their actual performances, and the algorithms with proven quantum advantage will not be implemented soon. This intermediate scenario opens exciting avenues and poses several challenges. How to systematically identify tasks where a quantum advantage over classical computers can be obtained in the near term? Once they are found, how to certify that the same computation cannot be reproduced by any classical means? ENCHANT, gENeral CHAracterisation of Near-Term quantum advantage regimes, proposes a radically new vision: the development of a comprehensive toolset to characterise the remarkable realm of near-term quantum advantage regimes. The toolset is meant to provide three fundamental assets for such an ambitious task: (A) a general framework encompassing the algorithms that can be run in current devices, compatible with their main limitations and constraints. We envision to obtain that by means of a careful classification of the families of states that can be obtained as the output of near-term quantum computation, (B) an assortment of task-tailored classical algorithms to simulate the performances of quantum devices. Here the interest is two-fold: to provide comparative methods to assess the quality of those devices and to identify tasks with no quantum advantage over classical computers, (C) a selection of techniques to certify quantum effects in computation and relating them to the hardness of simulating the same task classically. To make them amenable for quantum advantage regimes, we look for methods that rely on partial information about a quantum system.

Mots clés : quantum computing, tensor networks, quantum information

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet EMAMs (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Ceramic-based high-temperature structural electromagnetic absorption materials (EMAMs) is playing an increasingly important role in combating the EM pollution. However, ceramic-based EMAMs always suffer from poor mechanical strength due to the intrinsic high brittleness, and unsatisfactory EM performance limited by the material characteristic as well as the monotonous loss mechanism of absorbents. In this project, advanced SiCN matrix modified with one dimensional (1D) carbon nanofibers/2D transition metal carbides (e.g., TiC, VC and Mo2C) (CNFs/TMCs-SiCN) ceramic-based structural EM metamaterials will be innovatively developed by combining molecular-level-engineered polymer derived ceramic (PDC) and Additive Manufacturing (AM) techniques. Novel 2D TiC, VC and Mo2C nano-absorbents/reinforcements will be developed via a precursor-derived method. Outstanding EM performance is expected to be realized by the establishment of multi-loss mechanisms (i.e., interface, defect-induced and dipole polarization loss, and conductive loss) via nano/microstructure engineering of CNFs/TMC absorbents, and realization of novel meta-structures using AM. Improved mechanical strength will be achieved by strengthening of the SiCN matrix by CNFs/TMCs. The main idea of the present proposal is to merge material type and nano/microstructure innovation of absorbents/reinforcements as well as meta-structure innovation of materials to innovatively develop the CNFs/TMCs-SiCN structural EM metamaterials as the next generation high-temperature structural EMAMs. The general relationship between (nano- and micro-)structure, macro-structure (by design) and loss mechanisms, EM and mechanical properties will be revealed. This project will pave new avenue for the development of next generation EMAMs.

Mots clés : transition metal carbides additive manufacturing electromagnetic metamaterials polymer derived ceramics

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet ValCon (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

All languages change at variable rates through time. Several language internal and external factors have been considered as underlying mechanisms for such change. Language internal factors have been successful in modelling chains of changes within the system, but their relevance as initial triggers remain controversial. In this respect, language external factors are frequently invoked, among which language contact holds a prominent role. Languages are not in contact per se, however, people are: languages are in contact because people acquiring them as grammatical systems store them both in their brain and use them both alternatively. The question is what drives potential interferences between the systems (crosslinguistic influence) and if it can trigger diachronic change. This project proposes a new, replicable methodology for testing hypotheses on the mechanisms underlying diachronic change and verifies it by testing the hypothesis that such mechanism corresponds to priming, intended as the facilitative effects of an encounter with a stimulus on subsequent processing of the same or a related stimulus. Priming has been shown to be active both within and, crucially for our objectives, across languages (multilingual & L2 populations): in multilingual settings, the frequent activation of a linguistic structure of Grammar A could lead to produce said structure in the system of Grammar B, sparking the process of language change. I test this hypothesis by exploiting the fact that different phenomena show consistently different rates of change and checking if there is a significant correlation between such rate of change and the strength of priming affecting a given phenomenon. The Italian area, where a wide range of well-studied varieties coexist with Italian as a majority language in a comparable sociolinguistic environment, offers the perfect testing ground for this methodology, paving the way for the psycholinguistic study of crosslinguistic microvariation.

Mots clés : historical linguistics, psycholinguistics, priming, dialectology

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209483.28 €
Projet MoSSGIn (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

In modern algebraic geometry, a key approach to studying algebraic varieties — and more broadly, orbifolds (quotients of varieties by finite groups) — is through their categories of sheaves. Sheaves are algebraic objects that encode crucial information about varieties and orbifolds, including their geometric subvarieties and solutions to equations defined on them. Packaging sheaves into moduli spaces allows a systematic way to study the structure and properties of the underlying orbifolds.  This proposal focuses on moduli spaces of sheaves on three-dimensional complex orbifolds, which are of particular significance in theoretical physics, notably for capturing instanton dynamics in Calabi-Yau compactifications in type II string theory. Our main objective is to study the local geometry of these moduli spaces under pair-stability conditions and explicitly compute the associated Pandharipande-Thomas (PT) invariants, which are crucial for both enumerative geometry and string theory. The research is structured into three scientific work packages (WP):  WP1 will introduce and study poset Quot schemes—a generalization of classical Quot schemes—which parametrize flags of quotient sheaves, nested according to finite posets. This tool will provide the foundation for further computations. WP2 will focuse on moduli spaces of stable pairs over local stacky curves, which are defined by rank 2 vector bundles over smooth projective curves with marked points and prescribed ramification indices. We will develop new methods to reduce the complexity of PT invariants computation to performing intersection theory on poset Quot schemes, making the problem more tractable and leading to explicit closed formulas for these invariants. WP3 will aim to prove the Gromov-Witten/PT correspondence for local stacky curves, a conjecture that has driven much of the research in enumerative geometry over the past two decades. Proving this correspondence would represent a major breakthrough in the field.

Mots clés : moduli spaces, sheaves, curves, calabi yau, local curves, hilbert schemes, quot schemes, donaldson thomas, stable pairs, young diagrams, k theory, virtual fundamental class, derived geometry, tqft

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet POPULISMCONTAGION (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

The European Council included a free and democratic Europe on its strategic agenda for 2024-2029. However, the success of several populist parties is a serious threat to achieving this goal. Understanding how mainstream politicians respond to this pressure can reveal shifts in the broader democratic discourse. Focusing on French parliamentary elections between 1958 and 2024, for which there are individual candidate manifestos, this project will be the first to credibly show how political candidates strategically adjust their campaigns to populist opponents. The project will use natural language processing methods to study the adjustment in three dimensions: policy topics, their rhetorical complexity, and the level of populism. Leveraging regression discontinuity designs and exploiting two-stage elections and the quasi-random presence of a populist candidate in the second round, the project will show the causal effect of populist candidates on mainstream ones. The project will also provide for the first time evidence of whether this adjustment is constrained to the political campaign or impacts the legislative activity of elected politicians by analysing their policy topics, the complexity of their legislation, and the level of populism in their debates.

Mots clés : populism, political economy, elections, candidate positions, legislative behavior

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet LEGEND (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting 10 million people worldwide. No curative treatments are currently available, but only symptomatic ones. Emerging evidence highlights lysosomal dysfunction as a key mechanism in PD pathogenesis, with associated mutations in the LRRK2 and SNCA genes, both linked to lysosomal pathways. This proposal aims to identify common lysosomal biomarkers associated with PD progression. By employing the innovative LysoIP method, which enables precise lysosome isolation, we will analyse lysosomal profiles in two PD mouse models of LRRK2 and alpha-synuclein across different ages. Our objectives include (1) setting up and validating the LysoIP method in wild-type mice, (2) identifying potential lysobiomarkers in PD mouse models, and (3) validating these biomarkers in cellular models of PD. This project directly aligns with the EU Work Programme under Horizon Europe, which focuses on advancing our understanding of neurodegenerative diseases and accelerating the discovery of disease-modifying therapies. Identifying lysosomal biomarkers will not only improve our understanding of PD mechanisms but also support the development of novel therapeutic approaches targeting lysosomal dysfunction.

Mots clés : parkinson s disease, lysosomes purification, protein trafficking, mouse brain, human ipscs

Participants :
- Université de Dundee (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209483.28 €
Projet METACT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the liver manifestation of metabolic syndrome, consisting in a hepatic accumulation of lipids. While MAFLD is predicted to concern near 50% of the global adult population in 2040, no medication has been developed to counter its progression. Recent studies have identified a novel interorganelle communication in the liver, that consists in the endoplasmic reticulum engaging contact sites with both mitochondria and peroxisome, hence termed as peroxisome-endoplasmic reticulum-mitochondria (PEWM) complex. Individually, mitochondria-endoplasmic reticulum contact sites (MERCS) and peroxisome-endoplasmic reticulum contact sites (PERCS) have been described to regulate mitochondria function and peroxisome biogenesis, respectively. Although the formation of a tri-organellar complex suggests an interplay between MERCS and PERCS, this has not been evaluated yet. Recent report have shown that lipid metabolism regulation affects PEWM complexes formation. Additionally, MERCS abundance correlates with the progression of MAFLD, further suggesting a role of PEWM complexes in MAFLD pathogenesis. We will develop innovative PERCS- and MERCS-specific imaging probes to evaluate how changes in energy substrates availability affect simultaneously the formation of MERCS and PERCS. Our second objective is to deepen the understanding of PEWM complex as a regulatory hub, by questioning whether and how the modulation of MERCS and PERCS alters the function of peroxisome and mitochondria, respectively. Furthermore, we will identify the components of MERCS and PERCS that impart their metabolic sensitivity. Finally, we will evaluate in vivo how integrity of PEWM complexes is regulated throughout the progression of MAFLD. We will study animal models of PERCS deficiency to assess their interplay with MERCS and their role in MAFLD pathogenesis. This could lead to the discovery of a novel therapeutical target for treating MAFLD.

Mots clés : mitochondria function, inter organelles membrane contact sites, metabolic dysfunction associated fatty liver disease, pewm complex

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet BionovFOOD (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Food systems have created demand for addressing adequate nutrition, safe, healthy, accessible, and affordable food, under the pressure of increasing trend of the global population (projected to reach 10 billion by 2050), climate changes, pandemics, economic crisis, growth in the dietary supplements segment and many more. Sustainable and cost-efficient development of innovative food sources are needed to meet the projected nutrition demand, which have recently attracted the attention of both producers and consumers. Conversely, the significant losses and waste production by the processing industries are becoming a serious nutritional, economical, and environmental issue. The aim of BionovFOOD project is to propose novel approaches to valorize the distillery organic by-products and to include them into a biorefinery system. These will be used as raw materials in processes aimed at the recovery/separation of bio-products, with a focus on the production of proteins for food application. To reach this goal will be developed on a pilot-demo scale, process concepts for bio converting grape marcs, wine lees and vinasse, generated from the distillery industry, into protein-rich ingredients to be used for the production of alternative food products. Life cycle assessment and techno-economic aspects for the production of protein sources produced from edible and safe fungi will be investigated. With proteins produced will be designed and developed novel food. BionovFOOD project constitute the starting point for the understanding that distilleries’ by-products can significantly contribute to the future production of alternative protein-rich fungal biomass for food applications. Indeed, it will create synergies and co-benefits across 4 priority areas: nutrition and healthy diets; climate and environment; circularity and resource efficiency; and innovation. This project is a unique opportunity for my career and will boost my scientific profile.

Mots clés : alternative protein distillery by products circular bioeconomy fungi biomass novel food

Participants :
- Université de Borås (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €