Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet POTPLOS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Innovative heat transport devices are needed to break-though the increasing need for smaller, faster and lighter microelectronic apparatus. A Pulsating Heat Pipe (PHP) is a promising two-phase passive loop device that has many advantages such as high heat transfer capacity, construction simplicity, lightweight, and low-cost. However, the practical use of PHP has been limited due to insufficiency of design tools, i.e. predictive models for hydrodynamic and heat transfer phenomena. The aim of this proposal is to establish a universal model to predict operating limit of PHP and provide an optimal design solution that maximize PHP heat transport capability. An innovative approach using advanced measurements with high-resolution and high-speed infrared cameras and Inverse Heat Conduction Problem (IHCP) techniques will be taken to reveal the local thermal phenomena of the liquid-vapor interaction and obtain important physical parameters to implement the model. Both an experimental and a modelling approach will be used to reach the project goal. The project will bring together two complementary set of skills, with the researcher’s expertise in PHPs and the supervisor’s expertise in thermal tomography. In addition, a secondment in a leading company of two-phase thermal devices is foreseen, to increase the researcher’s competence in manufacturing and testing. The fellowship will support the researcher’s professional development to be a leader in the thermal fluid dynamics field. The impact of the action will be maximized with scientific publications as well as a broad range of outreach activities such as video pills and public talks to non-technical audiences, with a special target to young females to booster research careers in technology and engineering. Results of this MSCA have the potential to strengthen the European research and industrial leadership, promoting the use of PHP in several industrial applications, including aerospace, automotive and energy sectors.

Mots clés : two phase flow, thermal engineering, pulsating heat pipe, thermal tomography, infrared analysis, inverse heat conduction problem

Participants :
- University of Parma (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171473.28 €
Projet VAIM (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Inorganic polymers are of great interest as a result of their interesting properties, which offer exciting opportunities for their use as functional materials. Currently inorganic polymers generated through dehydrocoupling of group 13/15 amine- or phosphine-borane adducts are atactic and lack crystallinity, precluding their use in a variety of applications. The proposed research targets stereoregular polyaminoboranes and polyphosphinoboranes, inorganic analogues of stereoregular polyolefins, and potentially block copolymers, through catalytic dehydropolymerization using chiral earth abundant transition metal catalysts. The stereoregular polymers and block copolymers will be characterized in detail, and potential applications explored. To achieve these objectives a highly talented young scientist, Dr. Vincent Annibale, wishes to work in the highly multidisciplinary and internationally leading research group of Prof. Ian Manners at the University of Bristol for 2 years. Dr. Annibale has a wealth of expertise in synthetic transition metal chemistry from his previous postdoctoral and Ph.D. work. With a Marie Sklodowska Fellowship Dr. Annibale would gain exceptionally valuable experience and would become proficient in the field of polymer and materials science, which would be extremely important for his future career, preferably in academia, or in industry.

Mots clés : main group chemistry, catalysis, new inorganic materials

Participants :
- University of Bristol (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet DURETO (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Insects are gaining resistance to commercially available pesticides and effective insecticides (e.g. neonicotinoids) are currently being banned. Consequently, there is a real threat that the EU vegetable production will be affected. Wild tomato species have the ability to defend themselves by producing natural defence compounds that have a toxic or repellent effect on insects. These compounds are produced and stored in glandular hairs (trichomes) on the plant stem and leaf surface. Extensive breeding in protected environments led to the loss of these defence compounds in cultivated tomatoes. It was previously shown that the introduction of the terpene 7-epizingiberene biosynthetic pathway from a wild tomato in trichomes of cultivated tomato results in an enhanced resistance to insects. However, the regulatory factors that govern the production of these defence compounds seem also essential for successful incorporation of ‘wild resistance’ into breeding material. Here, I aim to discover metabolic defence mechanisms present in the trichomes of wild tomato species that can be re-introduced into cultivated tomato with a focus on post-transcriptional regulation of biosynthetic pathways. I will evaluate insect resistance in a collection of wild and cultivated tomato accessions and associate phenotypic and transcriptional data via a Systems Biology approach. I will also sequence small RNAs and compare them quantitatively with messenger RNAs to identify post-transcriptional regulations. Next, I will follow a comparative genomic approach by mapping the selected transcripts to their corresponding tomato genomes to associate polymorphisms and resistance phenotypes. These results will be directly translated into molecular markers that the industry can implement in breeding programmes. This proposal will help me become an independent researcher, combining my background in plant biology with knowledge on bioinformatics, biostatistics and state-of-the-art technology.

Mots clés : tomato, insect resistance, domestication syndrome, genetical diversity, trichomes, terpenoids, transcriptional network, systems biology, breeding, molecular marker

Participants :
- University of Amsterdam (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet DRiveR (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Insects pollinate 80% of crop plants in Europe and pollination services contribute €22 billion to the European economy annually. The honeybee (Apis mellifera) is the most extensively managed pollinator species, yet populations are declining. Understanding the biology of the honeybee and and factors contributing to its decline is critical for food security and maintenance of biodiversity. The honeybee has evolved a remarkable life history strategy where only one female is responsible for the majority of reproduction. The other females, the workers, forgo reproducing to care for the queen and her offspring. The presence of a reproductive queen is communicated via pheromones, arguably the most important of which is Queen Mandibular Pheromone (QMP). This pheromone inhibits ovary activity in worker bees and in its absence worker bees can activate their ovaries and lay unfertilised eggs that will become males. QMP is detected by the antennae and brain, but it is not currently known how the signal, initiated by QMP, is passed to the ovary. In this fellowship the applicant will address this fundamental gap in our knowledge by testing her hypothesis that dopamine acts to link the brain and ovary with exposure to QMP in the honeybee. The applicant will determine the role of dopamine signalling in maximising colony productivity and harmony and whether this is altered by sub-lethal doses of neonicotinoid pesticides. The experimental approach proposed in this fellowship is highly innovative as it combines state-of-the-art techniques both for measuring gene expression (RNA-seq) and for ovary culture and transplantation in honeybees. The applicant will combine these molecular approaches with behavioural ecology and colony monitoring (new skills that she will acquire under this fellowship) to understand not just how cells within the honeybee ovary respond to QMP, but how this signal affects the whole animal, its behaviour and, ultimately, the performance of the colony.

Mots clés : honeybee, queen mandibular pheromone, dopamine, reproduction, molecular mechanism, gene expression, behaviour, signalling between brain and ovary

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet EuReCa (Horizon 2020, appel à projets 2018)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

Institut Curie proposes an innovative COFUND programme, EuReCa (Europe Research & Care) with the following aims: (1) to train a new generation of early-stage researchers (ESRs) able to achieve excellence in basic sciences and their clinical and industrial applications in cancerology; (2) to implement innovative actions for career support exposing ESRs to our ‘3i’ vision: international, intersectoral and interdisciplinary experience; (3) to consolidate its leadership within its wide network of public and private partners, facilitating exchange of best practices in innovative doctoral training, providing a structured and effective training program to prepare ESRs to successfully enter the increasingly competitive labour market. Institut Curie is a leading Excellence Cancer Centre bringing together an internationally-renowned interdisciplinary Research Centre and Hospital Group. This proposal will benefit in particular from the expansion of Institut Curie’s unique bench-to-bedside approach which brings together new research teams synergizing the expertise of basic scientists and physicians. The strong focus of this proposal on fostering interactions between basic and clinical research as well as the industrial sector will create a new generation of scientists able to quickly transfer results from fundamental research to patient care. This will take the form of diagnostics, prognostics, predictive biomarkers and imaging tests, treatment strategies, new drugs, new radiotherapy techniques, and public health initiatives on prevention and screening. At Institut Curie, the ambitious ESRs fellows of the EuReCa programme will be involved in the three pillars of the fight against cancer: Cutting-Edge Research, Advanced Healthcare, Information & Data Management. EuReCa aims to build a multi-faceted community able to communicate, interact, build and share expertise to tackle the challenges of cancer, ultimately leading to better health outcomes and fewer deaths due to cancer.

Mots clés : cancer, health, translational research, epigenetics, genetics, cell biology, physical chemistry, biophysics, immunology, systems biology, biomarkers, epidemiology, personalized medicine

Participants :
- Institut Curie (France) — Coordinator, beneficiary, Recherche, subvention : 3173040.0 €
Projet FUSION NIGHT (Horizon 2020, appel à projets 2014)
Action : European Researchers' Night
Statut du projet : CLOSED

Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences (IAR&FR), in partnership with Olsztyn School of Higher Education (OSHE) invites kids, tweens, teens and adults to join FUSION Researchers’ Night – a unique occasion when science, entertainment and education meet in one place! Fusion Night is an incredible blend of research, innovation, fun and education that introduces young people to meet scientists who live in their city but whose work reaches across the whole world. The FUSION Night (FN) programmes revolves around the activities that will increase the awareness of the community at large about the importance of research careers and the central role of scientists in improving the daily life and well-being of European citizens. Visitors of the FN will have a chance to join edutaining activities, become a researcher for one night and give lecture to their peers (Polish Academy of Kids), test the content of vitamins in juice or milk (“Vitamins fusion or health illusion?), discover the secrets of cryopreservation in a mobile laboratory (“Ice land”), develop their own creams using fruit powders (“Tasty skin”), design a book from scratch (“Night in the Library”), learn the secrets of animal biodiversity (“Take a walk on the wide side”) or make a fruit puree in liquid nitrogen (“Molecular Show of Fusion Kitchen”). Sport enthusiasts can expect swimming competitions, basketball game, salsa course and martial arts training all conducted by our young researchers. We haven’t forgotten about the music and art lovers too, preparing for them a live concert of an international group of English teachers and an exhibition of science curiosities captured on the stained glass. Collaboration with partners from industrial circles will help to provide visitors with a first-hand view of the products and innovations “born” thanks to the solutions provided by science and researchers.

Mots clés : impactof science on daily life, edutaining activities, young people, fascinating research careers, innovation, connecting researchers with the public, life sciences

Participants :
- Olsztyńska Szkoła Wyższa im. Józefa Rusieckiego (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 15500.0 €
- Polish Academy of Sciences (Pologne) — Coordinator, beneficiary, Recherche, subvention : 65500.0 €
Projet GLIODIABESITY (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Metabolic disorders such as obesity and diabetes are age-related diseases, and lead cause of death in Europe. Adiposity signals such as leptin and insulin, whose circulating levels are in proportion to body fat, convey metabolic information to neural networks that regulate energy homeostasis in the hypothalamus. In leptin-deficient humans and mice, leptin administration effectively reduces hyperphagia and obesity. Paradoxically, most cases of obesity display high circulating leptin levels that fail to reduce appetite or increase energy expenditure. This raises the possibility that leptin transport across the blood-brain barrier to the cerebrospinal fluid (CSF) or to its sites of action within the hypothalamus is a limiting step defective in obese patients. The host laboratory recently demonstrated that tanycytes, a hypothalamic glia lining the floor of the third ventricle, were responsible for shuttling leptin from the periphery to the CSF and that such conduit was blunted in mice with diet-induced obesity. Leptin transport by tanycytes could thus play a critical role in the pathophysiology of leptin resistance. The overall objective of this project is to further elucidate whether the alteration of the adiposity signals transport into the metabolic brain across hypothalamic barriers is the main cause of the onset of obesity. To this end, a combination of in vitro and in vivo approaches, using genetically modified mice and pre-clinical models of obesity, will be implemented in order to elucidate the molecular mechanisms for the transport of blood-borne leptin into the CSF by tanycytes. It is anticipated that implementation of this project will expand our knowledge of the mechanism underlying human obesity and hold therapeutic potential for treating it. Besides, the proposed project is endowed of solid formative contents that will strengthen the experience of the applicant, boosting her future scientific career and paving the way for closer scientific collaborations.

Mots clés : obesity, leptin, hypothalamic barrier, tanycytes, glial cell, er stress

Participants :
- Université de Lille (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173076.0 €
Projet DyCLE (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Metal hyperaccumulator plants accumulate extraordinarily high concentrations of toxic metals in their leaves. The large within-population variation in the extent of hyperaccumulation of some metals in the field remains unexplained. Is this an acclimation, and to which environmental factor? Or is it a result of evolutionary adaptation, and what selects for it? To answer these questions, the applicant will employ results from a large field survey of Arabidopsis halleri, a model species capable of hyperaccumulating cadmium (Cd), published by the host group. The researcher will monitor dynamics of leaf Cd accumulation in the A. halleri populations exhibiting the largest intra-population variation in this trait in the field. In individuals contrasting for the degree of Cd accumulation, the researcher will quantify the response to herbivore attack, as well as the genetic contribution for leaf Cd accumulation. High-quality research in the host laboratory (Ruhr University Bochum, DE) and knowledge on soil-plant-insect interaction will enhance EU scientific excellence. The researcher will engage in collaboration with a secondment (Bielefeld University, DE) for scientific exchange and the synergic transfer of high-quality complementary scientific and methodological expertise, thus strengthening EU internationally leading position in toxic metal ecology. Expected results will enable best protocols for plant-based clean-up (phytoremediation) of metal-contaminated soils that are unsafe for agriculture and a significant issue in the EU. This project will delineate the inter-disciplinary independent career of the researcher, enhance his knowledge and provide personalised training in state-of-the-art research methodology. He will participate in management and group meetings and train students for skills and knowledge transfer. Scientific publications for experts, as well as seminars, articles, a web video and social e-media for the public will efficiently disseminate the results.

Mots clés : metal hyperaccumulation, cadmium, arabidopsis halleri, within population metal accumulation variation, mamestra brassicae, metal defence, metal toxicity, organic compounds toxicity, joint effects

Participants :
- Ruhr University Bochum (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 174806.4 €
Projet RealNanoPlasmon (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Metal nanoparticles absorb and scatter light much more than their physical size would suggest. This is caused by localized surface plasmon resonances formed upon light illumination in the nanoparticle. The plasmon resonances are characterized by collective oscillations of free electrons in the particle, but soon after its formation, typically on a femtosecond timescale, the collective plasmon mode decays via emission or via non-radiative creation of electron-hole pairs. As a result of the latter decay mechanism, high-energy electrons and holes, so-called hot carriers, are left behind. When these plasmon-induced hot carriers escape from the nanoparticle to the environment, or are induced there directly, they can be utilized for multitude of applications, such as photovoltaics, photocatalysis, or photodetection. Similarly to the plasmon resonance, the distribution of plasmon-generated hot carriers is highly dependent on the size, shape, and composition of the nanoparticle. In recent years, atomic-scale effects on plasmon resonances have become increasingly scrutinized theoretically and computationally along with sophisticated experimental techniques. Despite this development, for plasmonic hot-carrier generation the bulk of the present understanding is based on model systems or approximative methods neglecting the underlying atomic structure. The aim of this project is to develop first-principles methods for addressing plasmonic hot-carrier generation by fully accounting for the atomic structure and elemental distribution, and shed light on atomic-scale effects on hot-carrier generation by virtue of the developed methods.

Mots clés : nanoplasmonics, time dependent density functional theory, tddft, nanoparticles

Participants :
- Chalmers University of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191852.16 €
Projet EMOF (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Metal-organic frameworks (MOFs) are coordination polymers synthesized by bonding organic ligands with metals or metal clusters. Recently, exotic electronic properties have been predicted theoretically for two-dimensional (2D) MOFs, such as topological non-trivial band structure (2D organic topological insulators and so on), superconductivity, half-metallic ferromagnetism and quantum spin liquid. 2D MOFs have been synthesized on metal surfaces by following the concepts of supramolecular coordination chemistry. However, molecular adsorbates on metal surfaces interact strongly with the underlying metal substrate. Therefore, their electronic properties are drastically modified. This project will focus on synthesizing and investigating the intrinsic exotic electronic properties of 2D MOFs on insulating, weakly interacting, and tunable gated substrates by ultra-high vacuum low-temperature Scanning Tunneling Microscopy and Spectroscopy with non-contact Atomic Force Microscopy. In order to achieve these ambitious targets, I have divided this proposal into three work packages: 1. synthesizing 2D MOFs on inert surfaces; 2. structural and electronic characterization of 2D MOFs; 3. tuning the exotic electronic properties of 2D MOFs on gated graphene devices. The applicant and the host group have initial results on the topics discussed in this proposal and are thus in a unique position to make ground-breaking contributions in this area. Understanding and tuning the growth and the electronic properties of MOFs will offer a versatile platform to realize topological electronics as well as different kinds of novel phenomenon in condensed matter physics. The bottom-up synthesis techniques guarantee a technological route which can easily be scaled-up to be used for applications. Longer term, the biggest impact is expected through applications of MOFs in dissipationless electronics and spintronics.

Mots clés : low temperature scanning tunneling microscopy  lt stm, non contact atomic force microscopy  nc afm, ultra high vacuum  uhv, organic topological insulator  oti, metal organic framework  mof

Participants :
- Aalto University (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 190680.96 €