Projet IMPROVE-PD (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Peritoneal dialysis (PD) is an underused life saving renal replacement therapy for end-stage kidney disease. Nevertheless, PD patients remain at high risk for poor outcome, most notably excessive risk of cardiovascular disease. There is an unmet need for a risk-adjusted individualized PD approach. The IMPROVE-PD consortium provides 15 Early Stage Researchers (ESRs) in 11 partner institutes located in 7 different countries a state-of-the-art, multidisciplinary and intersectoral pan- European training programme including input from academic, clinical and industrial stakeholders. Network-wide and local training activities, individual research projects, intersectoral secondments and short laboratory visits will provide key generic skills and will prepare ESRs for future roles as highly skilled researchers in Europe. Well-phenotyped patient cohorts, and novel experimental models and techniques will be exploited by the ESRs, mentored by an excellent supervisory team, to improve future management of the PD patient at risk. This joint effort encourages productive collaboration between industrial and academic sectors though integrated projects and shared goals. Key findings will be communicated to a broad range of stakeholders through state of the art methods. IMPROVE-PD will give rise to a new generation of experts in PD with outstanding interdisciplinary research skills, intersectoral understanding and with perspective to pursue their careers in this scientific and industrial field. It will enable timely identification of the PD patient at high risk for adverse outcome, develop understanding of underlying pathomechanisms, and within an iterative process between research groups foster the development of innovative approaches to individualized treatment by targeting revealed pathomechanisms. Through these approaches, the ITN will achieve refinement of PD fluids, PD therapy and cardiovascular risk reduction.

Mots clés : peritoneal dialysis, chronic kidney disease, systemic inflammation, cardiovascular disease, personalised medicine, disease registries, experimental models, human tissue, phase i, phase ii studies

Participants :
- University Hospital Heidelberg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 505576.8 €
- Australia and New Zealand Dialysis and Transplant Registry (Australie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Catholique de Louvain (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 256320.0 €
- North Bristol NHS Trust (Royaume-Uni) — Partner, organization partner, Recherche, subvention : 0.0 €
- Hospital Universitario La Paz (Espagne) — Partner, organization partner, Autres, subvention : 0.0 €
- Medical University of Vienna (Autriche) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Kidney Research UK (Royaume-Uni) — Partner, organization partner, Recherche, subvention : 0.0 €
- Epsilon 3 gmbh (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Poznan University of Medical Sciences (Pologne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Europd ev (Allemagne) — Partner, organization partner, Autres, subvention : 0.0 €
- Autonomous University of Madrid (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 250904.88 €
- Baxter medical products gmbh (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 264207.24 €
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 501809.76 €
- Zytoprotec (Austria) (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 528414.48 €
- Ghent University (Belgique) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Cardiff University (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- Medical University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 212833.61 €
- Fresenius (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- CERCA Institution (Espagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 274802.04 €
- Nierstichting (Pays-Bas) — Partner, organization partner, Autres, subvention : 0.0 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 265619.88 €
- Keele University (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €