Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HISTHEOL (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

'History and Theology: the creation of disinterested scholarship from dogmatic stalemate (ca. 1525-1675)' will deal with the question of how and why the seeds of religious tolerance came to be sown in an age of confessional polemic. This project will explore the idea that an unexpected consequence of religious polemic was the growth of disinterested scholarship, which, in turn, led to increased tolerance of religious differences. Indeed, once the strict rules and staunchly held positions of the rival confessional antagonists became known and established, scholars were able to pursue their research relatively freely within this framework and even across confessional boundaries. It became possible to describe change and diversity as historical facts rather than as simply polemical weapons in a battle of the books. In turn, this paved the way for the religious tolerance championed by several influential Church histories of the Enlightenment. The project will focus on two cultural zones: England and the Italian peninsula, in order to conduct a comparative study of a carefully selected number of key scholars from rival confessions and scholarly traditions. By means of a carefully calibrated dissemination strategy, this project is intended to have a wider impact on Europe’s troubled multi-faith society of the early twenty-first century by providing a fresh, new historical narrative which adds intellectual foundations to the moral desirability for mutual recognition and appreciation of diversity in religious debate.

Mots clés : theology, religious history, early modern history, history of tolerance

Participants :
- University of York (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet NEWHORIZONS (Horizon 2020, appel à projets 2014)
Action : European Researchers' Night
Statut du projet : CLOSED

'New Horizons Festival, A Night out in Science, Art and Music', is all about meeting science and scientists. As part of European Researchers' Night in 2014 and 2015, the Rotterdam based festival features researchers from Erasmus University Rotterdam and its strategic partners Delft University of Technology and Leiden University. 'A Night out' means that visitors will experience science by meeting face-to-face with researchers and taking part in demonstrations, experiments and dialogues. Exceptionally, the form of a lecture is used, for example to present a top speaker who combines scientific excellence with very good presentation skills. New Horizons Festival was formerly organized as 'Discovery Festival'. Every year the festival has a theme which is leading in the program. The theme of the 2014 edition is 'Big data, Your life in the cloud.' Researchers from diverse disciplines, such as life and medical sciences, psychology, economy, ICT and philosophy will focus on applications of big data approaches in their field and implications on society. The theme of 2015 has not yet been decided on. The main target group consists of people from 17 to 37 years old, the typical curious audience looking for new information and experiences which are relevant for their personal life and society; generally speaking this is the audience of nightlife and (pop-)festivals. But the festival is also attractive for people who are older and curious to learn about science and its relevance to society. For school pupils in the age from 6 to 12 and 15 to 17 a special program is organized during Friday afternoon. Apart from science, the festival incorporates art and music, which contribute to the festival experience. Art is a way to challenge, and reflect on science. Artists who are selected are inspired by scientific topics or scientific methods. Venues of the festival are Erasmus University Rotterdam, cultural institutes as well as the public space in Rotterdam, all in the city centre.

Mots clés : science festival, outreach, rotterdam, erasmus university, european researchers  night

Participants :
- Stichting science street (Pays-Bas) — Coordinator, beneficiary, Autres, subvention : 182500.0 €
Projet GliomaChip (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Statut du projet : CLOSED

28% of all primary brain tumors and central nervous system tumors and 80% of malignant tumors are gliomas, which arise from the supportive tissues in the brain. Yet, our ability to effectively treat these cancers is limited by our knowledge of the disease and our ability to test new treatments on accurate models. Advances in microfluidics and cell encapsulation within hydrogels have made significant strides in trying to meet these needs, but the potential to use these technologies for engineering physiologically relevant tissue models has yet to be fully realized. Here, we propose to investigate cancer biology using a microfluidic device with three-dimensional (3D) micro-patterned cellular constructs that may be subjected to flow through microfluidic channels. Using the developed model, we aim to understand the cellular gliomagenesis, glioma cell migration, and angiogenesis and further test drug susceptibility to demonstrate the relevance of the proposed model. To achieve these goals, I have formulated an innovative and interdisciplinary strategy based on my research experience in bottom-up tissue engineering and microfluidics, and brought together a strong team. First, I will receive an intensive training at the Max Planck Institute for Intelligent Systems on micro-robotics to strengthen the bridge between the fields of micro-robotics and bottom-up tissue engineering. Then, I will get a training at the Harvard Medical School on glioma cell culture and cell extraction from a mouse model. Finally, all these efforts will be integrated into the development of an in vitro 3D glioma-on-a-chip model mimicking the complex in vivo microenvironment of glioma. The successful completion of this timely and innovative project will result in an advanced microphysiological system that will contribute to the competitiveness of Europe in the fields of cancer management, pharmaceutics, and personalized medicine.

Mots clés : micro robotics, glioma, organ on a chip, microfluidics, tissue engineering

Participants :
- Koç University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 157355.52 €
Projet CAC-seq. (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

5-carboxycytosine (5caC) has been robustly identified in mammalian DNA. It is known that this DNA modification plays a role in epigenetic demethylation processes. If 5caC has other epigenetically relevant functions is so far unknown. Due to its low abundance it is technically challenging to study this modification in biological samples. Identification of specific readers, recognition by the RNA polymerase II elongation complex, the presence in specific genomic loci as well as changing levels during differentiation of mouse embryonic stem cells (mESCs) point towards an important biological function. A chemical tool that would clarify the role of 5caC in mammalian biology is so far missing. Since DNA modifications play a significant role in human diseases, understanding their functions offer new opportunities for novel treatment strategies. Chemical tools have advanced the field enormously in detecting and analysing newly discovered modified bases by rationally designed chemistry for specific labelling of a given modification. Chemical enrichment of DNA fragments enables mapping of the bases at 200-400 base pair resolution and has been used for a genome-wide mapping of several DNA modifications. To obtain single base resolution a separate modification specific sequencing method needs to be applied after enrichment. To avoid a multistep procedure I will develop a chemical enrichment method for 5caC that is directly coupled to single base resolution sequencing. In combination this provides a powerful chemical tool that has far reaching impact for other researchers in the field and finally enables scientific progress on 5caC.


Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet 6i-DIRS (Horizon 2020, appel à projets 2018)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

6i-DIRS will recruit 19 qualified ESRs for high quality doctoral training to · promote their social contributions; · generate interdisciplinary, international and intersectoral projects and dissertations; · support and broaden their career prospects. Grounded on a robust, dynamic and attractive ecosystem, 6i-DIRS fosters cooperation and co-creation among 7 PhD programmes and 19 externally evaluated excellence teams, that support them with research and training around · 5 interdisciplinary platforms on EU and global challenges: Ageing and Wellbeing; Cultural and Creative Industries, Cities and Regions; Gender; Social Justice and Inclusion; and Strengthening Participation; · 4 interdisciplinary areas aligned with the Basque Smart Specialisation Strategy on Health; Sustainable Development and Innovation in Energy, Industry 4.0 and Mobility. DEUSTO has prime conditions for frequent dialogue between economic, cultural and social actors. 46 established partners and 15 co-financing entities back 6i-DIRS, ensuring international and intersectoral mobility to broaden ESRs’ employability. Recruitment will be open, merit-based, impartial, equitable and international. It will avoid any form of discrimination, with international recommendations for transparent and ethical assessment at the core and in line with the European Charter and Code of Conduct and benefiting from H2020 Gearing-Roles project on institutional change. Successful candidates will sign an employment contract, and will have shared supervision and mentoring as detailed in the Doctoral Agreement and their individual training plan. Full internationalisation is essential in 6i-DIRS, COFUND will - consolidate the rate of international ESRs (34% of PhDs in 2017/18); - help with capacity building with Eastern institutions, sharing strengths and lessons learned; and - consolidate DEUSTO’s internal procedures to attract international talent and grow in scientific excellence, innovation, social engagement and impact.

Mots clés : excellent research and training, international, interdisciplinary, intersectoral, social impact, innovation, inclusion, researcher career, transnational and cross sectoral mobility, open recruitment, best practices

Participants :
- University of Deusto (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1545840.0 €
Projet NCMS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

A Marie Sklodowska-Curie IF at ETH-Zurich will lead to major developments of the PI's current research. The PI's research focuses on better understanding the mathematical implications of the physical dualities that arise in the study of string theory. Mirror symmetry, which is a kind of duality in string theory, equates two physical theories called the A-model and B-model. Mirror symmetry predicts that the A-model (resp. the B-model) of a space/variety is equivalent to the B-model (resp. the A-model) of its mirror space/variety. In mathematics, the A-model corresponds to Gromov--Witten (GW) theory, which is one of the first modern curve counting theories in enumerative geometry. To a physicist, a complex curve represents the worldsheet of a string propagating through space-time. In 2018, the PI initiated a new research program which provides a novel approach of using orbifold techniques to count curves in algebraic varieties with tangency conditions along co-dimension one sub-varieties (divisors). This novel approach defines a generalization of relative GW theory which plays a central role in mirror symmetry. Several major advances have been achieved in the past two years and a new research direction has been created. This proposal focuses on this new research program and its applications to curve counting theories and mirror symmetry. We expect to build a firm foundation for our new theory and expand this program along various directions. The proposal is divided into three main projects. The first project focuses on structural properties of the new GW theory and its relation with punctured GW theory. The second project explores applications of the new theory to several aspects of mirror symmetry including Gross--Siebert program, the Strominger--Yau--Zaslow (SYZ) conjecture and the Doran--Harder--Thompson (DHT) conjecture. The third application focuses on its connections with other curve counting theories.

Mots clés : gromov  witten theory, curves, mirror symmetry, gross  siebert program, orbifolds, stacks, calabi  yau manifolds, logarithmic geometry

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203149.44 €
Projet FIMS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

A breakthrough in economically viable efficient energy conversion has been long waited, with fuel cell technology being a promising candidate. Recently, tubular Solid Oxide Fuel Cells (SOFCs) have received increased attention due to possibility to shorten start-up times, reduce material losses and lower costs of fuel cells. In order to reach sufficient volumetric power density, decrease working temperature and reduce costs, the diameter of the SOFC tubes has to be reduced at least an order of magnitude, compared to state of the art (at or above 1 mm). In the recent years, the hosting group of the project has demonstrated fabrication of yttria-stabilized zirconia (YSZ) microtubes with diameters <100 µm and tested their viability for use as an electrolyte in microtubular SOFCs. The FIMS project is focused on innovative development of controllable YSZ microtube fabrication methods and subsequent use of the microtubes in construction of a SOFC stack to prove commercial potential. A method for fabrication of optical quality fluorescent microtubes with controlled dimensions (diameter <100 µm, wall thickness 5-10 µm) and facile structural defect detection with optical techniques will be realized. Porous electrode deposition on the microtubes will be refined and a microtubular electrolyte supported pilot SOFC stack will be constructed and characterized. The target of FIMS is to promote transfer of knowledge through training and career development of the Fellow in the multidisciplinary field of SOFC technology, in order to re-enforce professional maturity and independence of the Fellow. Two secondments – academic and industrial – further improve the training and collaboration network of a young scientist. The project will have positive impact on the Fellow's career progress towards becoming a leading researcher, and supports enhancement of environmental protection and sustainable resource use.

Mots clés : sofc, microtubular sofc, fluorescence in metal oxides, sol gel

Participants :
- University of Tartu (Estonie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 154193.28 €
Projet FLAMMES (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

A central goal of modern neuroscience is to correlate neurological conditions, external stimuli and behavior with the activity and location of individual neuron within a large brain volume. Thus, simultaneous recording of brain activity and organism behavior are fundamental to characterize circuit alterations underlying neurological disorders and to assess potential attenuation strategies. Thanks to the high degree of morphological, genetic and behavioral resemblance with humans, zebrafish is becoming a prominent model for studying neurological disorders and screening of neurospecific compounds. Owing to reduced light scattering, small size and 3R-principle compatibility of the zebrafish larvae, parallel whole-brain neuroimaging of multiple zebrafish might pave the way of in vivo drug discovery. Recent studies report technological breakthroughs that enable monitoring of zebrafish whole brain activity with cellular resolution. Although widely used for functional imaging, larval zebrafish remains limited to manual, extremely challenging and low-throughput screening. Here, I propose to integrate my solid background in biophysics and micro-nano optics engineering with new skills I will build at the Host Institution and Secondment for the project success. Goal of this project is to enable optical whole-brain imaging of multiple zebrafish larvae (Danio Rerio) freely behaving. First, I will demonstrate zebrafish larva neuroimaging with a novel metasurface-based optical sectioning illumination (Aim 1). Second, I will demonstrate selective plane on-chip detection synchronized with the excitation plane (Aim 2). Finally, I will prove potential parallel larvae on-chip microscopy (Aim 3). The proposed neuroimaging concept is a flexible approach to perform high-throughput drug screening based on recordings of the brain activity and characterization of the behavior outcome. Collectively, this study will provide a platform that contribute bridging the gap from bench-to-bedside.

Mots clés : whole brain imaging, on chip microscopy, compact vision system, metasurface, drug screening parallelization, larval zebrafish, single cell resolution, behaviour

Participants :
- University of Padua (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183473.28 €
Projet plaNET-seq (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

A common challenge for all organisms is to interact favourably with their environments. The blueprint to do so is in their DNA. We understand relatively well DNA units that code for proteins but cutting-edge genomic technologies have identified predominantly non-coding regions that respond to environmental cues. Thus, how widespread non-coding transcription may be functional represents a key question in modern biology. My proposal addresses this topic by studying nascent transcription by RNA Polymerase II (Pol II) during plant environmental interaction. The novel and innovative approach promises unprecedented detail and down to single nucleotide resolution of active Pol II transcription dynamics in response to environmental cues. It will capture non-coding transcripts before they are degraded, enabling us to investigate the molecular events in largely mysterious yet abundant components of the genomic blueprints of life. Owing to their sessile life-style, plants are experts in mediating compensatory regulation to respond to the environment. Hence, they are particularly promising models to yield answers to this contemporary scientific question. A major interest of the action will be how plants respond to low temperature. I will generate genomic maps of Pol II in the act of transcription that will reveal the dynamics of transcription in response to low temperatures. In a targeted approach, I will identify and characterise the dynamics of coding and non-coding transcription in the genomic regions responsible for cold acclimation. My strong background and solid track record, the expertise and potential of the host supervisor together with the infrastructure and encouraging scientific atmosphere at the host department will synergistically contribute to maximise the output of the proposal. It will strengthen the competitiveness of Europe and develop and diversify my skills as an independent researcher and prepare me for a successful career within academia.

Mots clés : nascent elongation transcription sequencing, cold acclimation, arabidopsis thaliana, pol ii transcription, plant molecular biology

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet SLMK (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

A fundamental philosophical question is whether the mind can be mechanised. Attempts to answer it so far have been inconclusive; I argue that with the tools of mathematical logic this question can be sharpened and addressed in a framework where genuine progress can be achieved. I will consider a disjunctive thesis proposed by Gödel (known as Gödel's Disjunction) as a precise version of this question. Once sharpened, the question becomes whether a Turing machine (an idealised computer) can output exactly the statements that are 'absolutely provable'—i.e. the mathematical statements that can be proved in principle by an idealised mathematician not bound by limitations of time and cognitive resources. Gödel's Disjunction states that either the powers of the human mind exceed those of a Turing machine, or there are true but unprovable mathematical statements—i.e. mathematical statements that are beyond the reach of human reason. My proposed research will provide a novel account of 'absolute provability' or 'provability in principle' by developing a formal framework that overcomes the philosophical and technical shortcomings of the previous approaches. Having formulated the correct framework for absolute provability and uncovered its underlying mechanisms, I will be able to determine the status of Gödel’s disjunction. This will shed considerable light on the question of whether mind can be mechanised, a question central to philosophy of mind and artificial intelligence, and on the scope and limits of mathematical knowledge.

Mots clés : mathematical knowledge, mind and machine, absolute undecidability, g del s disjunction

Participants :
- Ludwig-Maximilians-Universität München (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 159460.8 €