Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HaemMetabolome (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks - Joint Doctorates
Panel : Life Sciences
Statut du projet : CLOSED

It has long been realised that metabolism is central to cellular development, proliferation and homeostasis. Collectively, aberrations in metabolism are now recognised as a major hallmark of cancer, opening new avenues for personalised medicine. As haematological malignancies are multi-factorial diseases, our main emphasis will be on the integration of biomedical multi-omics data and computational systems modelling with the ultimate aim to understand metabolic regulation in haematological cancers. HaemMetabolism is design to unravel the regulatory mechanisms that link cell cycle control and metabolism. For this we will screen a panel of haematological cancer cell lines for the metabolic phenotypes and against a library of inhibitors. Gene-function analyses will be performed using shRNA libraries directed against key metabolome regulators. Validation will occur in primary patient samples in vitro and in vivo in preclinical humanized niche xenograft mouse models. A systems biomedicine approach will be integrated build genome-scale transcriptional models that explain deregulated metabolic pathways relevant for the development of haematological malignancies. This work will not only open new avenues for drug discovery but will also provide a multi-disciplinary framework for student training in biomedical technologies.

Mots clés : metabolism of haematological cancers

Participants :
- Goethe University Frankfurt (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 498432.96 €
- University Medical Center Groningen (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 510748.56 €
- Tavargenix (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 819863.64 €
- LifeGlimmer (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Barcelona (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 743618.88 €
- Bruker (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet IAV-m6A (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

It has recently become apparent that post-transcriptional editing of mRNA by methylation of adenosines (m6A) plays a key role in regulating gene expression. In particular, total loss of m6A editing blocks the development of early embryos in a number of organisms. However, how m6A modifications, which are added in the nucleus and primarily detected by 3 cytoplasmic “reader” proteins, exert their effects remains unknown. The presence of m6A on viral transcripts has been known for 40 years, yet has only recently been shown to enhance HIV-1 gene expression and replication. Influenza A virus (IAV) that, like HIV-1, replicates in the nucleus, is known to bear a high level of m6A on viral RNA. However, whether and how m6A editing affects IAV replication remains unknown. Here, the researcher proposes the investigation of the role of m6A in IAV pathogenesis. The main objectives of this proposal are; to compile a precise map of m6A sites on IAV-PR8 RNA, determine their functional significance on replication and RNA trafficking, assess how m6A machinery is altered in IAV infected cells, and evaluate the conservation of these sites across additional pathogenic IAV strains. Preliminary data demonstrates that IAV gene expression may be enhanced by overexpression of the m6A reader proteins. Therefore the researcher proposes that IAV may subvert the m6A modification pathway to enhance viral RNA expression. Mapping of m6A modifications will be performed using PAR-CLIP and PA-m6A-seq, while RNAi, CRISPR knockouts and lentiviral overexpression systems will be utilised to determine the functional role of m6A editing on IAV pathogenesis. This fellowship will provide the researcher with an excellent opportunity to work at 2 highly regarded research institutes and advance his knowledge in virology and RNA biology. The skills acquired through completion of this fellowship will greatly assist him in his future endeavours including the establishment of his own European research group.

Mots clés : influenza a virus, rna methylation, pathogenesis

Participants :
- Institut Pasteur (France) — Coordinator, beneficiary, Recherche, subvention : 264668.4 €
- Duke University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet CORA (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

It has recently been discovered that archaea are promoting ammonia oxidation, an important process in nitrogen cycling. Ammonia oxidizing archaea (AOA) use Cu containing enzymes to oxidize ammonia to nitrate. Therefore, they have an elevated Cu requirement and thus the bioavailability of Cu to archaea may impact the nitrogen cycle. However, the molecular mechanism of Cu uptake by Archaea from terrestrial and aquatic environments remains unknown. Understanding the molecular mechanism of Cu uptake by these archaea will be an important step in understanding Cu acquisition by the Archaea. The first objective of this study will be to determine what types of proteins are potentially involved in Cu uptake under Cu limiting conditions. The hypothesis that low concentrations of Cu will result in expression of Cu acquisition genes will be tested using different strains of AOA originating from soil and hotspring environments and varying the availability of Cu to the AOA. The gene expression of AOA cultures as a function of Cu availability will be monitored using transcriptome illumina sequencing. The hypothesis that soil AOA will secrete extracellular reactive compounds to mobilize Cu as part of a Cu acquisition strategy will be tested. The presence of a strong copper binding ligands using a colorimetric assay and by an electrochemical method. The second objective of this study will be to use different strains of AOA in batch incubation experiments with different previously characterized Cu containing soils and minerals. The hypothesis that AOA isolated from soil environments will have high efficiency Cu uptake systems compared to AOA from the aquatic environment will be tested in batch incubations with AOA cell cultures and different Cu containing soils and minerals. This study will be innovative as this problem has not previously been addressed.

Mots clés : archaea, copper binding ligand, copper, ammonia oxidation, nutrient acquisition, dissolution rates

Participants :
- University of Vienna (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 178156.8 €
Projet IMOS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

It is becoming increasingly evident that small changes in the efficiency of the Biological Carbon Pump BCP can significantly alter ocean carbon sequestration and, thus, atmospheric CO2 and climate. Despite their importance, the factors that drive the BCP variability are poorly understood. As a consequence, current annual global estimates of the magnitude of carbon (C) export from the surface ocean via the BCP vary up to 400% (from 5 to 21 Gt C yr-1). IMOS will focus on increasing the precision of the export assessments and restraining the variability by taking advantage of some of the most promising technological advances in in-situ imaging and autonomous sampling combined with state of the art methods and powerful simulation tools. Specifically, IMOS will use particle imaging with high resolution underwater cameras, UVP (Underwater Vision Profiler) type, which will be combined with a uniquely modified autonomous float to allow for the first time simultaneous in-situ particle imaging and sinking particle collection. The overall research objective is to link optical properties to direct C flux measurements to obtain higher resolution quantification of C export in the oceans via the BCP. The fellow will spend the first 2 years at the Woods Hole Oceanographic Institution (WHOI) under the supervision of Dr. Ken Buesseler. The last 12 months will be spent at the Universidad de Sevilla (USE), under the supervision of Dr. María Villa-Alfageme. She will return to Europe with the technical expertise required to work with unique field measurements and develop improved global parametrizations of the BCP efficiency, which are key areas of expertise for describing the present and future role of the BCP in global climate models. Research results will be of interest to worldwide researchers working on the study of the impact of the BCP on the global C cycle, promoting European excellence and competitiveness in dedicated European and international carbon export projects.

Mots clés : biological pump, ocean carbon cycle, carbon export, drifting sediment traps, underwater technology

Participants :
- Universidad de Sevilla (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 245732.16 €
- Woods Hole Oceanographic Institution (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet miRNAs in TH2 cells (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

It is estimated that more than 200 million Europeans suffer from at least one type of allergy. This condition is elicited by an hyper-activated type-2 inflammatory response coordinated by T helper (TH)-2 cells. In spite a good insight into the molecular mechanisms that triggers TH2 cells activation, the lack in understanding their post-transcriptional regulation is hampering the access to new potential therapeutic targets to curtail the allergy epidemic. Micro-RNA (miRNAs) are regulatory molecules essential for life, which play a fundamental role in shaping cellular functions via post-transcriptional repression of the cellular transcriptome. Though previously considered to operate exclusively inside the parent cell, it is now acknowledged that miRNAs can exit cellular boundaries and control transcription in bystander cells. We recently reported that regulatory T (TREG) cells secret specific miRNAs to repress TH1 cell-mediated immunopathology, and ameliorate a mouse model of autoimmune disease. In this proposal, we will address the role of extracellular miRNAs for the normal T cell development and during allergic inflammation of the airways. To this end, we produced a novel animal model that allows - for the first time - to selectively ablate the activity of extracellular miRNAs in T cells. We will use biochemical, RNA-sequencing and bioinformatics analysis to identify the molecular mechanisms for miRNAs sorting to exocytosis and to identify the miRNAs transferred to and from TH2 cells. This proposal will significantly expand our understanding of transferred miRNAs in the contest of health and disease, and will uncover novel cellular pathways to exploit as therapeutic targets.

Mots clés : extracellular mirnas, t cell development, allergy, helminth infection

Participants :
- UK Research and Innovation (Royaume-Uni) — Partner, beneficiary, Recherche, subvention : 0.0 €
- The Francis Crick Institute (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 183454.8 €
Projet MASCOT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

It is expected that in the coming decades the population living in urban areas will increase dramatically. Therefore, the sustainability of our planet depends critically on a smart and energy-efficient operation of cities. Wireless communication technologies arise as one of the main enablers to reach this goal. For example, services and applications such as intelligent transportation, industry automation, and mobile healthcare will require to accommodate a vast number of heterogeneous and battery-limited wireless devices connecting asynchronously and sporadically to the network. This is commonly known as the massive connectivity problem. Since traditional wireless communication technologies were not designed to support this kind of services and applications, there is a need for a profound theoretical study of this problem. The main objective of MASCOT is to characterize, from an information-theoretic perspective, the fundamental limits and tradeoffs of the asynchronous massive connectivity problem. To this end, I will derive in the outgoing phase at MIT nonasymptotic bounds and asymptotic expansions characterizing these limits. In the return phase at Universidad Carlos III de Madrid, I will then explore different strategies to efficiently and accurately compute the nonasymptotic bounds derived at MIT. During the course of the project, I will elaborate guidelines about how future wireless communication schemes must be designed, and I will adapt existing schemes according to these guidelines. The proposed training activities during the fellowship are fundamental for the correct achievements of MASCOT as well as to secure my future career goals. MASCOT guarantees a two-way transfer of knowledge since it combines my past expertise on elaborating and efficiently evaluating fundamental limits of low-latency wireless communications with the supervisors’ expertise on information theory applied to the massive connectivity problem and asynchronous communications.

Mots clés : finite length information theory, wireless massive connectivity, asynchronous communications

Participants :
- Carlos III University of Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 263732.16 €
- Massachusetts Institute of Technology (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Science at Aveiro (Horizon 2020, appel à projets 2014)
Action : European Researchers' Night
Statut du projet : CLOSED

It’s our intention to organize the 9th and 10th edition of the Researchers’ Night initiative – The Science@Aveiro, General public and researchers – Closing the Gap. We propose two events for 2014 and 2015, around the themes of “Materials” and “Light” respectively. Besides the different themes, this integrated edition will not forget the fact that in 2015 the Researchers Nigth’ initiative will celebrate their 10th anniversary. To celebrate that, in 2014 we will launch the “Competition 10th anniversary of Researchers’ Night”, involving categories on drawing, photography and video. This competition is on the theme “Research is everywhere” and it is dedicated to the general public but we expect more in impact at the students’ community. The location for both events will be the City of Aveiro. Aveiro is in the centre of an industrial spot, diversified in terms of sector of activity and one of the most dynamics in Portugal. Furthermore, Aveiro is known as the city of research and innovation, as a consequence of the projects that have been developed in different areas and to his Innovative University (Universidade de Aveiro). The broad aim of the Science@Aveiro event is to bring researchers closer to the Portuguese society and tourist present at the Aveiro City highlighting the researchers “ordinary character”. The target group for this activity is the large public without any distinction of social categories, educational level, gender, age, etc. Different subcategories like kids, teenagers, adults, teachers, parents, “ordinary people”, researchers, entrepreneurs, tourists, politicians are to be reached as parts of the general public. The Science@Aveiro project will be implemented by Universidade de Aveiro - Fábrica Ciência Viva Science Centre and Globaz, SA. With the support of Municipality of Aveiro, Association for Education and Exploitation of Aveiro Region and Group of Schools Aveiro.

Mots clés : aveiro, portugal, university, researchers, public, students

Participants :
- University of Aveiro (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 77225.0 €
- LOBA - Customer Experience Design (Portugal) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 76900.0 €
Projet INpaCT (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Joint injuries are very frequent, especially among young people. Such injuries seldom heal and over time can lead to cartilage degeneration and ultimately osteoarthritis. Although, it is generally assumed that excessive mechanical loading post-injury can cause or accelerate the progression of cartilage degeneration, the precise mechanisms involved in the pathological processes at different structural length scales are still not fully understood. Thus, novel approaches for understanding structure-function relationships from the cell to tissue level in both health and disease are necessary. The overall aim of this research is to investigate the mechanisms of cartilage damage progression at different levels of tissue organization. The novelty of this research lies in the highly interdisciplinary approach of combining an in vitro model of OA progression with the state-of-the-art materials testing devices, computational modeling and sophisticated microscopic, spectroscopic and molecular biology techniques to carefully assess the mechanics, structure, composition and gene expression on cell and tissue levels. The novel data obtained from this research will shed light on the key mechanobiological pathways by which cartilage cells maintain healthy tissue or mount a healing response following tissue injury and excessive loading. This project is conducted as an international collaboration between University of Eastern Finland, Kuopio, Finland and Massachusetts Institute of Technology, Cambridge, USA. This represents a unique opportunity to bring together the complementary skill sets of Dr. Florea, Dr. Korhonen’s group and Prof. Grodzinsky’s group, with their expertise in biomechanics, computational modeling, biochemistry and cartilage biology. The mutually beneficial collaboration between Europe and USA can advance the field of cartilage research with significant potential to provide novel strategies to reduce/prevent cartilage degeneration for patients in Europe and beyond.

Mots clés : biomechanics, atomic force microscopy, cell mechanics, cartilage mechanics, computational modeling, mechanobiology, post traumatic osteoarthritis

Participants :
- University of Eastern Finland (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 267793.2 €
- Massachusetts Institute of Technology (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SRSAI (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Just over a century ago, Douglas fir (Pseudotsuga menziesii) trees in Europe were confined to a handful of botanical gardens; today, they cover more than 800,000 hectares of European soil, making them the second most common non-native tree species on the continent. Large-scale diffusion of this North American species across Europe began in the late 1910s and early 1920s, carrying enormous implications not only for European ecosystems but also for the continent’s political economy and environmental practices. This happened by design, not chance; behind this massive ecological transformation was an American-led plan to exert new forms of influence over the Old World. SRSAI aims to test the hypothesis that the mass transfer of Douglas fir seeds from the U.S. to Europe carried social, political, cultural, economic, and ecological implications for the restructuring of the world order in the early twentieth century. The Great War disrupted Europe’s wood supplies. Americans stepped in to replenish the continent’s forests, reshaping local landscapes and political economies in a way that advanced a U.S.-centric agenda. Importantly, SRSAI brings together histories of international relations and the environment to reveal new insights for both by connecting war, transatlantic exchange, forestry, and the rise of the U.S. as a global power.

Mots clés : environment, u s, european, international relations, history

Participants :
- Fondation nationale des sciences politiques (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €
Projet KNOWPEC (Horizon 2020, appel à projets 2015)
Action : Staff Exchanges
Panel : Environment and Geosciences
Statut du projet : CLOSED

KKNOWPEC, Knowledge for pesticides control, aims to create a transnational research network between Europe and Latin America focused on the challenge of unwanted pesticides in the environment. KNOWPEC wants to identify the occurrence and fate of banned and toxic pesticides in drinking and natural waters in agricultural areas of Latin America where knowledge on occurrence and risk is scarce. KNOWPEC wants to assess the environmental and potential human risks of the pesticides detected, and to provide solutions for both reducing pollution at source, and remediating contaminated water. Together, KNOWPEC will promote the sharing of knowledge at each step from pesticide analysis, toxicity and risk assessment to advanced treatment technologies that jointly enables the design of sustainable solutions to each pesticide pollution problem. Moreover, we want to create the tools of information and networking for a source of collaboration between European and Latin America institutions under the framework of the environmental and human protection from pesticides. KNOWPEC will make important contributions increasing the knowledge of pesticide pollution in potable and natural waters in selected Latin America locations providing typical (or exemplary) cases of widespread agricultural practices and ecological regions. This, together with the application of knowledge from a network of experts in chemical analysis, environmental toxicity and risk assessment, and innovative water treatment technologies in training future specialists, will contribute to safeguarding drinking water supplies and providing solutions for sustainable food production, and a sustainable environment.

Mots clés : pesticide pollution, risks assessment, pesticide removal

Participants :
- Universidad de Costa Rica (Costa Rica) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Barcelona (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 139500.0 €
- University of Buenos Aires (Argentine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Copenhagen (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 139500.0 €
- University of San Simón (Bolivie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Fera Science (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 108000.0 €
- Democritus University of Thrace (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 139500.0 €