Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CRAFT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

CRAFT aims to investigate Graeco-Roman funerary cartonnage from the Fayum Oasis, Egypt. The project raises and addresses new questions about the manufacturing of Ancient Egyptian cartonnage artefacts (mummy masks, foot-cases, full body covers) with an innovative approach that focuses on the multi-disciplinary study of such objects, never analysed in depth before. Through an Egyptological approach combined with enhanced, non-invasive archaeometric investigations, as well as with high-resolution 3D reconstructions of artefacts preserved in international museums, CRAFT will generate an unparalleled understanding of Graeco-Roman cartonnage artefacts and the socio-cultural milieu within which they were manufactured. Expected outcomes include advanced research collaborations, addressing questions of cultural heritage preservation, determining provenance, influences, regional features, and religious significance of a so far uninvestigated category of funerary objects.


Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- National Research Council (Italie) — Coordinator, beneficiary, Recherche, subvention : 251002.56 €
- Yale University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Anti-CRISPR (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

CRISPR-Cas immune system represents one of the most effective weapons against mobile genetic elements in the host defense arsenal. Bacteriophages (phages) armed with anti-CRISPR proteins can, however, inhibit CRISPR immunity by sabotaging components of the immune system with evolutionary advantages. This proposal sets out to discover novel phage-encoded anti-CRISPR proteins and understand the molecular mechanisms of the inhibitory processes. I will focus on novel anti-CRISPR proteins for Cas9-containing type II CRISPR-Cas systems in lactic acid bacteria (LAB). I expect anti-CRISPR proteins to be present in phages for LAB, for which the CRISPR system is an important line of defense. It is highly plausible that LAB-infecting phages have evolved to possess anti-CRISPR proteins. However, none of anti-CRISPR proteins against type II CRISPR have been described so far. To identify novel type II anti-CRISPR proteins encoded by phage genomes and explore novel features of the anti-CRISPR proteins, I will establish high-throughput screening methods using an integrated approach consisting of metagenomics, bioinformatics and mass spectrometry. After identifying candidate anti-CRISPR proteins, I will uncover the underlying molecular mechanisms of these viral anti-CRISPR proteins utilizing state-of-the-art single-molecule fluorescence methodologies. The fierce virus–host arms race has resulted in high diversity of distinct prokaryotic CRISPR-Cas systems. Therefore, I anticipate that my high-throughput screening will lead to discovery of remarkably diverse anti-CRISPR proteins, specifically anti-CRISPR variants targeting Cas9. The proposed combination of viral diversity screening and single-molecule approaches will reveal novel mechanisms of anti-CRISPR activity that are difficult to obtain by traditional biochemistry, will impact potential applications of Cas9, and will provide unique insights into the host-virus arms race.

Mots clés : crispr cas, anti crispr, cas9, metagenomics, bioinformatics, high throughput screening, single molecule, fret, tirf microscopy

Participants :
- Delft University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet CROWDMERSE (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

CROWDMERSE enables real-time capture, processing, and reproduction of an immersive audio experience to the user of any event of interest, focusing on “crowded” acoustic events. Acoustic scenes with large audiences, such as sports events or music concerts, present significant challenges for immersive reproduction which have not been so far adequately considered in the signal processing community. Technological breakthrough in sports events broadcasting has a strong potential impact on media providers, and consequently on the European and global economy. The challenges of capturing and reproducing crowded acoustic events include the need to spatially capture and reproduce numerous sound sources, such as the applause and yells of the spectators, in addition to the “main” sounds of the event. Concerns regarding the privacy of the spectators must not be overlooked: the conversations of the audience members sitting near the microphone sensors must be eliminated. In order to spatially sample large venues, the acoustic sensors should be low-cost, small-sized, and support wireless operation. The developed algorithms should respect the limited sensor resources, while operating in real-time to enable commercial applications. Our final objective is to enable real-time delivery of crowded acoustic events so that the designed platform can be integrated with today’s High-Definition TV programs. CROWDMERSE focuses on sound capturing using multiple closely placed microphones forming a microphone array. The audio content is rendered through a home entertainment system equipped with multiple loudspeakers, accompanying the content of a typical HDTV broadcast. Addressing the scientific challenges and proposing a solution which can be integrated with current broadcasting principles is guaranteed given the previous involvement of the experienced researcher in sports broadcasting projects. The proposed methods are expected to have impact in the general area of immersive sound environments.

Mots clés : spatial audio, microphone arrays, immersive audio

Participants :
- Audyssey laboratories inc (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Cidana corporation (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Foundation for Research and Technology Hellas (Grèce) — Coordinator, beneficiary, Recherche, subvention : 254457.0 €
Projet CReScenDo (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

CReScenDo aims at quantifying the extent and thickness of peatlands from the local to the regional scale, to accurately define their importance in the global carbon cycle. Peatlands are extraordinary reservoirs of organic carbon (almost matching, according to some estimates, the atmospheric carbon pool), which is currently being released into the atmosphere due to a number of often anthropogenic degradation processes (e.g. soil drainage, fires, etc.). The conservation of peatlands is therefore a key measure to reduce CO2 emissions and to mitigate climate change (e.g. according to the Intergovernmental Panel on Climate Change). However, regional and global estimates of peat deposits remain highly uncertain and an effective quantification methodology is still missing, negatively impacting our ability to plan effective conservation strategies. The innovative approach proposed by CReScenDo combines passive and active satellite remote sensing and geophysical data collected from airborne platforms to map extent and thickness of peat deposits at regional scale. The proposed methodology will yield a set of integrated observations providing the first large-scale picture of the relations among peat deposits, geomorphological features, and soil and environmental characteristics. Three peatland areas (two in Europe and one in Asia) are selected to implement and test the methodology, using field observations to improve the accuracy and quantify the uncertainty. The ability of the methodology to characterize/classify different peat types will also be tested and used to map the carbon pool stored at the three study sites. The applicant has a solid background in optical remote sensing and ecological modelling applied to salt-water wetlands. The hands-on training performed at the host institution and at a private company (Secondment) will provide her with new scientific competences in topographic and geophysical data analysis tools with tremendous impact on her mid/long-term career.

Mots clés : peatland detection, lidar, optical remote sensing, geophysics, airborne electromagnetic, organic carbon, co2 emissions, carbon cycle

Participants :
- University of Padua (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet CTFF (Horizon 2020, appel à projets 2017)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : SIGNED

CTFF is a major interdisciplinary project that combines wisdoms in three academic disciplines: Heat Transfer, Fluid Physics and Plasma Physics, to address the research problem on both active and passive control of turbulent friction force. The main focus is on developing techniques for the control of near-wall turbulent structures and the reduction of turbulent friction force, specifically at conditions relevant to engineering practices, by coordinating the efforts of European, the US and Chinese experts specialized in these three different but overlapping domains. New materials will be examined, novel numerical algorithms will be developed, and the numerical results will be tested in physical experiments. In brief, the main objective of this project is to coordinate the action of a group of Universities and enterprises, with complementary expertise in three disciplines from European countries, China and the US, to build and test an optimal solution for the reduction of turbulent friction drag, thereby facilitating the successful implementation of friction force control in engineering practices.

Mots clés : drag reduction, plasma actuator, superhydrophobic, heat transfer

Participants :
- KTH Royal Institute of Technology (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 40500.0 €
- Beihang University (Chine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Office national d’études et de recherches aérospatiales (France) — Partner, beneficiary, Recherche, subvention : 63000.0 €
- Koç University (Turquie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 54000.0 €
- Zhejiang University (Chine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- R.tech (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 27000.0 €
- University of Nottingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265500.0 €
- Xi'an Jiaotong University (Chine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Johns Hopkins University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Concordia University (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Oxford (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 54000.0 €
Projet DEFORM (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Caldera-forming volcanic eruptions can have severe impacts from the local to global scale. As vast quantities of magma are ejected during the eruption, they can trigger deadly pyroclastic density currents and lahars, release noxious gases and even alter global climate. At many calderas, episodic unrest in the form of pronounced uplift, increased seismicity and elevated gas emissions raise concern over the potential for such destructive eruptions. However, it remains difficult to ascertain whether the unrest observations indicate (1) an injection of new magma into the crustal reservoir, which could increase its potential for explosive eruptions, or (2) a sudden release of magmatic volatiles from a cooling and crystallizing reservoir, which would remain unlikely to erupt explosively. In this proposed project, I will develop a physics-based model of a magma reservoir to determine the processes involved in magma injection and evolution that may lead to episodic unrest. Of particular interest is how gases migrate through the system and alter reservoir volume. The model will simulate the thermo-mechanical evolution of a two-dimensional, three-phase (solids, liquids, gas) magma reservoir. By leveraging emerging continuum frameworks for reactive transport modelling, this work will expand existing two-dimensional models to simulate three phases in varying proportions in a computationally efficient approach. The reservoir model will be coupled to ductile-to-brittle crustal deformation to understand the conditions that lead to episodic unrest. I will compare simulation results with time series observations of ground deformation and gas emissions from Laguna del Maule in Chile, thought to be undergoing magma injection, and Long Valley in the US, thought to have experienced punctuated gas release. Results will bridge the gap among current models of three-phase magma dynamics and will improve understanding of the eruption hazard implied by caldera unrest.

Mots clés : computational geoscience, fluid dynamics, multiphase flow, continuum mechanics, thermodynamics, magma reservoir dynamics, crustal deformation

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 103539.28 €
- University of Glasgow (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 97594.64 €
Projet CanFaster-Postdoc (Horizon 2020, appel à projets 2018)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

CanFaster is a joint venture among industry, health care and academia to enhance and accelerate innovations and clinical implementation within oncology. The mission of CanFaster is to prolong and save lives of cancer patients through integrated development and commercialization/implementation of diagnostic/treatment alternatives, thus reaching the market and patient more rapidly. CanFaster will save lives of cancer patients, not for future generations, but for today´s. The CanFaster programme is enabled by an intimate collaboration between industry, health care system and academia, and will contribute to the Europe 2020 strategy, where one million new research jobs are needed to reach the Innovation Union flagship initiative. The aim of the present proposal for funding is to accelerate this process further by recruiting ERs to synergize with the already ongoing CanFaster doctoral programme. The collected track record of all partners demonstrates an impressive history of entrepreneurial spirit, state-of the art medical care but also truly world-class scientific excellence within translational cancer research. The proposed programme recruting 15 ERs, will be hosted within CREATE Health, a translational cancer research programme with broad international collaboration partners and excellent out-put for the last 12 years. Main objectives of CanFaster are (i) Increased transnational and intersectorial mobility (ii) Intersectorial improvements through intensified collaboration within oncology between academia, industry and hospital/regional health care organisations. (iii) Acceleration of innovation, attracting international investors leading to increased number of SMEs in the region and (iv) Education of a new generation of excellent multidisciplinary, entrepreneurial scientists. This is achieved through the attraction of the MSCA program for industrial partners to add-on to the EU and public national funding of the programme with financial and in-kind contribution.

Mots clés : cancer research, cross disciplinary, triple helix, advanced technologies, clinical implementation, life science, intersectoral, innovation

Participants :
- Lund University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1103400.0 €
Projet STARFISH DNA (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cancer is a generic term for a group of diseases characterized by the uncontrolled growth and spread of cells with abnormal proliferating activity. Most of the anticancer drugs currently used in the clinic trigger irreversible DNA damages and thus, promote replicative stress. As an alternative of irreversible DNA strand breaks, the non-covalent small-molecule stabilization of unusual, non-B DNA structures has emerged as a promising way to create DNA damages. One of such non B-DNA structures is a three-way DNA junction that might fold both upstream and downstream of the replication fork. The stabilization of three-way junctions by small molecules therefore opens a promising way to induce replicative stress in a highly cancer-specific manner. The main goal of the project "STARFISH DNA" (for "Stalling the Replication Fork via the Impedimental Stabilization of Higher-order DNAs") is to identify a new series of compounds capable of creating DNA damages through three-way junction stabilization and to use them either as standalone therapeutic agent to fight against cancers or in combination with established drugs that disrupt cancer signaling pathways in a synergistic manner.

Mots clés : cancer, dna damage response, replicative stress, cell imaging, three way dna junctions, twj ligand

Participants :
- Université Bourgogne Europe (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet PROVIST (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cancer is one of the most devastating diseases leading to millions of deaths per year, and cancer research is a major topic in many laboratories in academia and industry. The main goal in this proposal is to understand the biology of cancer progression that will lead to the discovery of new, more tailored and personalized anticancer therapies. One of the largest group of enzymes that greatly contribute in cancer progression are proteases. In this project I will leverage the production of highly selective chemical probes to investigate the contribution of medically important proteases in tumor progression in PDX (Patient-Derived Xenograft) mice models using a new analytical technique - mass cytometry. This goal will be achieved via a four-step approach employing techniques from organic chemistry, analytical chemistry, biochemistry and biology making this project multidisciplinary. Proteases that have been chosen for this purpose are caspases, legumain and cathepsins B, L and S for which I will synthesize very specific, small molecule radiolabeled inhibitors suitable for mass cytometry approach. These probes will be first evaluated on recombinant enzymes and simple cell systems and then they will be applied to PDX mice studies. PDX models offer an excellent possibility to study human cancer biology in system most closely related to in vivo pathology. So far there are no reports in the literature regarding the use of mass cytometry in studies of PDX mice models, which makes this project very unique and innovative. This PROVIST project will be performed in Sanford Burnham Medical Research Institute, USA (24-months outgoing phase, prof. Guy Salvesen Lab) and at Wroclaw University of Technology, Poland (12-months return phase, dr. Marcin Drag Lab). The research and training profile of these units fits all the objectives that are included into PROVIST project (scientific research and personal career development).

Mots clés : proteases, mass cytometry, patient derived xenograft  pdx  mice

Participants :
- Wrocław University of Science and Technology (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 227361.6 €
- Sanford Burnham Prebys Medical Discovery Institute (Etats-Unis) — Partner, organization partner, Recherche, subvention : 0.0 €
Projet MacrophInt (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cancer is the most common cause of death and morbidity in Europe. New therapeutic targets to combat this disease are critical. Across many solid cancers, poor prognosis largely correlates with the infiltration of tumour-associated macrophages (TAMs). TAMs enhance tumour progression and complicate various anticancer therapies. Although macrophages primarily employ amoeboid migration for homeostasis and immune functions, TAMs primarily utilize mesenchymal migration. Experiments in mice revealed that blockade of TAM mesenchymal migration lowers infiltration within tumours and reduces tumour growth. Targeting this distinctive feature has the potential to limit TAM recruitment in tumours and halt disease progression, while preserving healthy macrophage functions. The mesenchymal migratory mode involves podosomes and is characterized by integrin-mediated adherence to the surrounding extracellular matrix (ECM), and the requirement of ECM proteolysis. In sharp contrast, amoeboid migration is independent of podosomes and integrins. We will investigate and evaluate the potential of targeting integrin signaling as a new strategy to manipulate TAM infiltration into tumours. Elegant knock-in and knockout mouse models will be used to establish the key regulators of integrin signaling in TAM mesenchymal migration. This novel paradigm will be extended to TAM migration in human breast tumour specimens. We will also provide new insights at the subcellular level by exploring the roles of integrin signaling in the formation and function of podosomes. Our study endeavours to identify novel and unanticipated avenues for blockade of TAM mesenchymal migration and tumour infiltration to synergize with current combination therapies that simultaneously target both pro-tumour stromal cells and cancer cells. Targeting mesenchymal migration in macrophages could have far-reaching implications beyond cancer in other disease contexts that involve macrophages including chronic inflammation.

Mots clés : tumour associated macrophages, migration, tumour infiltration, solid tumours, adhesion, podosomes, integrin, talin1, inside out signaling

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 116953.92 €