Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet OriginStories (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

China became the largest source of adopted children worldwide since its Transnational Adoption Program in 1992.As adoptees are coming of age, some are interested in exploring their roots. Concurrently, as international adoptions come under the scrutiny of critical groups in sending and receiving countries, heritage tours have become a popular way to satisfy the needs of different actors involved: from adoptive families seeking the youths’ roots to economically minded tour operators and adoption agencies, to critical Western-based civil society groups who advocate psychological benefits for adoptees, such a resolution to their emotional befuddlement. Heritage tours are thus where transnational kinning practices are played out, different notions of belonging intersect, and broader state and organizational interests meet. Thus, these tours constitute the ideal case for studying the transnational family-making process from a truly transnational perspective. Through a detailed comparative study of how adopters and adoptees in Spain and the US-the countries with the largest number of Chinese adoptees-Chinese first parents, and Chinese and Western heritage tour agencies negotiate their different interests, my research will facilitate one of the first multi-sited and multi-actor perspectives on transnational kinning practices through transnational adoption. The study brings together recent literature on transnational families and transnational adoption and uses mixed methods from the social sciences and humanities to build a Transnational Adoptive Field approach intended to provide a comprehensive and cross-country comparative way to study transnational adoptive family-making processes and involves ethnographic fieldwork in three different countries, interviews with key stakeholders and narrative analysis. In a wider sense, this inquiry is a case through which we may scrutinize the shifting meanings that re-define familial and national belonging in today’s globalizing world

Mots clés : transnational adoption, migration, heritage tours, transnational families, transnationalism, kinship, china

Participants :
- Brown University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Maastricht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260929.8 €
Projet EnanSET (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Chirality of organic molecules plays a paramount role in our society as a consequence of the direct relation between the absolute molecular configuration and many properties and applications of molecular compounds and materials. The demand of enantiomerically pure compounds has increased considerably driven by the request of the pharmaceutical industry, as well as applications such as flavours, fragrances, and materials. In this context, the development of new methodologies to obtain enantiomerically pure compounds has become a challenge for the scientific community. This project entitled “Homogeneous and heterogeneous enantioselective Single Electron Transfer (SET) catalysis in cross-coupling reactions (EnanSET)” aims at developing novel enantioselective SET cross-coupling reactions of redox active esters (RAEs) by Ni-complex due to this kind of compounds do not need previous activation. Moreover, in order to develop more environmentally friendly processes, the methodology will be extended to non-toxic SET complex as titanium complexes, with the goal of developing the first Ti-catalysis of RAEs. Additionally, inspired by demand of the industrial processes, the need to develop clean and green chemical processes in order to avoid environmental concerns and the advantages that heterogeneous catalysis provides, we will develop the first SET heterogeneous catalysis with MOFs through the postsynthetic incorporation of chiral Ni or Ti-residues on the pore structure.

Mots clés : single electron transfer, enantioselective, catalysis, mofs

Participants :
- Scripps Research Institute (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Granada (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 239191.2 €
Projet ChOLLATERAL (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cholestasis refers to toxic bile acid accumulation mainly in the liver and can be induced by many chemical compounds, in particular drugs. At present, drug-induced cholestatic injury (DICI) is poorly predictable and is an important reason for drug withdrawal from the market as well as a major clinical issue. A solution lies in better understanding the mechanisms of DICI. A pragmatic tool to visually and rationally capture the mechanistic basis of toxic effects is the adverse outcome pathway (AOP). Current AOP constructs frequently provide a too simplistic reflection of the mechanisms underlying toxicity by underestimating initiating events and biological responses. This project aims to establish a realistic mechanistic scenario of DICI by producing an advanced AOP network that considers known initiating events of DICI and that quantitatively describes mechanisms of the adverse response as such as well as of the adaptive response activated by the body to counteract the adversity. This will be used as the basis for generating an in vitro test battery to accurately predict DICI. Such human-based and animal-free approaches to assess the safety of chemicals are urgently needed because of scientific and ethical reasons. AOP network development will rely on in vivo and clinical data collected from re-used samples (animal models of cholestasis and clinical cholestasis patients) and new in vitro data (human 3D spheroid model of cholestasis). This multidisciplinary and timely project will lead to a conceptual change in toxicology by introducing an innovative type of AOP network. Additionally, it will equally meet a ubiquitous medical need regarding the prediction of cholestatic liver toxicity, therefore, perfectly matching the objectives of this Work Programme. It is anticipated that this project will serve as a generic prototype to mechanistically and reliably predict any other type of chemical-induced toxicity without using animals.


Participants :
- Vrije Universiteit Brussel (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 178320.0 €
Projet EpiSyStem (Horizon 2020, appel à projets 2017)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

Chromatin is the basic regulatory unit of life, and as such it controls developmental and functional states of all cells, including pluripotency. In recent years methods to study chromatin and transcription have dramatically improved and expanded to genome-wide global approaches on the one hand, and single cell biology on the other, allowing systems-level understanding of epigenetic regulation of stem cells, reprogramming and development. The Epigenetics and Systems Biology of Stem Cells and Reprogramming Network (EpiSyStem) is comprised of 8 world renowned, ERC-granted researchers, 2 professional leading industrial partners and supported by 3 partner organizations and 3 international world acclaimed scientists as an advisory board, to provide a unique training environment. EpiSyStem combines chromatin biology in stem cells, early embryos and reprogramming, including the modelling of human neurological, chromatin-related diseases with bioinformatics, epigenetics/epigenomics, and systems biology at the population and single cell / single embryo level. This multidisciplinary approach will enable profound training and deep, systems-level understanding of chromatin biology and epigenetic regulation of stem cells, differentiation and reprogramming, with a strong support by industrial partners. The objectives of EpiSyStem is to create a European mesh in which 14 outstanding PhD students will be trained in fundamental questions of biological research, be exposed to the latest technologies and breakthroughs, supervised by leading experts with international contacts - with the aim to facilitate their path to future leadership with holistic view, coupled with the forefront of the current epigenetic research in the field. They will enjoy exchange programs, workshops on emerging topics in stem cell epigenetics and bioinformatics, international conferences and meetings, and will communicate their findings to the scientific community as well as the general public.

Mots clés : epigenetics, chromatin, nucleosome, pluripotency, methylation, histone, embryonic stem cells, ips cells, bioinformatics

Participants :
- University of Milan (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 516122.64 €
- Hebrew University of Jerusalem (Israël) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 780901.56 €
- Kadimastem ltd (Israël) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260300.52 €
- Diagenode (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 250560.0 €
- Institut Curie (France) — Partner, beneficiary, Recherche, subvention : 525751.2 €
- Helmholtz Zentrum München (Allemagne) — Partner, beneficiary, Recherche, subvention : 498432.96 €
- Radboud University Nijmegen (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255374.28 €
- Royal Netherlands Academy of Arts and Sciences (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 510748.56 €
Projet CKD AKI (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Chronic kidney disease (CKD) and acute kidney injury (AKI) are widespread in EU and worldwide, and put substantial burden due to disability, mortality, high cost of treatment, and risk for development of cardiovascular diseases (CVD). Both CKD and AKI are projected to grow due to many factors, including general population aging and increase in diabetes prevalence. Evaluating global and EU regional epidemiology of CKD and AKI is extremely important for understanding current trends and future challenges, and revealing differences of kidney disease in diverse populations. The current proposal is aimed to develop a single database and bibliographic web-based tool for collecting available evidence on CKD and AKI epidemiology worldwide; develop and apply bibliographic search strategy to obtain literature sources and extract multiple epidemiologic parameters for CKD, AKI, and their connection to CVD; produce advanced models for CKD and AKI estimates on the global, regional, and country levels; strengthen existing international collaboration in studying CKD and AKI epidemiology; disseminate results to scientific community, public health authorities, and general public; increase future competiveness and prepare ER for tenure-track position in academic institutions in the EU-member states. The proposal assumes inter-disciplinary approach and international cooperation, contains several innovative elements, intended to produce multiple new deliverables, strength EU-based research, provide substantial career development for the researcher. Major issues in the proposal are directly related to consequences of population aging and increasing the burden of chronic diseases, as well as interconnections between acute and chronic diseases. The results are expected to provide important information for public health planning in EU and worldwide for comparing morbidity, mortality, and provision of medical care.

Mots clés : chronic kidney disease, acute kidney injury, epidemiology, bibliographic information system, bibliographic search, modelling

Participants :
- Mario Negri Institute for Pharmacological Research (Italie) — Coordinator, beneficiary, Recherche, subvention : 168277.2 €
Projet NeuroCon (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Chronic pain patients cannot be efficiently treated with pharmacological methods and hence investigating alternatives such as psychological-based treatments is essential. One of the well-recognised method of analgesia is placebo which is based on learning processes – classical conditioning (CC). Through CC, expectations about pain relief are formed and those are recognised to mediate the placebo effect. Moreover, the effects of CC play a prominent role in the development of chronic pain-related fear and disability, so investigating the basis of fear conditioning may help developing better pain management strategies. Expectations about pain relief are shown to reduce the activation of pain-related brain regions and cues associated with pain decrease are processed in higher-order areas of the brain. However, the latest studies are inconclusive in determining to what extent expectations are elicited consciously or unconsciously and it is suggested that it depends the way the effect is generated - simple conditioning or conditioning with verbally induced expectations. In order to bring new light on this subject, the neural basis of the process and how the brain activity changes in order to recognise relevant and irrelevant information during conditioning still needs further investigation. In order to understand the relation between CC and expectancy in placebo analgesia, this project will implement both types of CC in the context of basic fear conditioning procedure. The brain activity will be measured using MEG and EEG technique and investigated using multiple methods of signal analysis which is a novelty in placebo research. The aim of the project is investigating how sensory cortices are modified to better detect relevant information using MEG and studying anticipatory brain activity using EEG. It may provide an answer to what extent conscious and unconscious processes are involved in pain modulation and what regions of are involved in this process.

Mots clés : placebo, fear conditioning, pain modulation, neuroimaging

Participants :
- Universidad Complutense de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet diaRNAgnosis (Horizon 2020, appel à projets 2020)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : SIGNED

Circulating cell-free ribonucleic acids (ccfRNAs) represent an emerging and important class of molecules, able to provide significant clinical relevance as novel screening, prognostic and therapy monitoring biomarkers in cancer. Through analysing specific ccfRNAs, different cancers can be accurately correlated for type and stage. Sadly, despite extensive academic and clinical research identifying and validating in limited clinical trials, ccfRNAs have not yet entered the field of clinical diagnostics. This is amongst others because the current analytical methods remain less than satisfactory, and until now ccfRNA detection remains therefore challenging, costly, and requires elaborate multi-step sample preparations. Prompted by these current analytical limitations, two innovative EU companies, DESTINA Genomica SL (Spain) and OPTOELETTRONICA ITALIA SRL (Italy) have developed the “ODG Platform” for direct quantitative measurement of circulating RNA molecules. The diaRNAgnosis project objective is to complete development of the ODG platform, delivering reliable and robust detection of novel ccfRNA signatures that could be linked to specific cancer types. To ensure timely delivery and success of the diaRNAgnosis project, DESTINA and OPTOI have considered and invited partners who they believe will add real value to the consortium. These are the Spanish company NanoGetic SL (specializing in nanotechnologies); three key academic research groups from the Universities of Trento and Catania (Italy), Granada (Spain); as well as the Princess Máxima Center (The Netherlands). This new pan-European, multidisciplinary and intersectoral team will develop a reliable and innovative method and platform to identify cancer biomarkers in liquid biopsies. The research collaboration will address the need to perform high sensitivity/high specificity analysis of ccfRNAs that are specifically and overexpressed in testicular germ cell tumour (TGCT) and prostate cancer (PCa) respectively.

Mots clés : liquid biopsy, peptide nucleic acids, molecular diagnostics, cancer biomarkers, prostate cancer, testicular cancer, microspheres, sensors, circulating cell free rna, microrna

Participants :
- Optoelettronica italia srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 41400.0 €
- University of Granada (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 87400.0 €
- Nanogetic sociedad limitada (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 41400.0 €
- Princess Máxima Center (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 124200.0 €
- Destina genomica slne (Espagne) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 230000.0 €
- University of Catania (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110400.0 €
- University of Trento (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 124200.0 €
Projet PepPtNPAntiCan (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Cisplatin is an efficient chemotherapeutic drug, yet it suffers from two main disadvantages: evolving drug resistance and relatively high toxicity. One of the latest approaches for dealing with these drawbacks has been the development of platinum nanoparticles (PtNPs) as a Pt(II) ion source. However, this solution is far from effective, mainly due to obstacles in cancer-cell targeting and a lack of nuclear penetration. The Wennemers group developed a combinatorial screening for the identification of peptides that allow for the formation of metal nanoparticles. The identified peptides control the geometric parameters of the nanoparticles and stabilize them in the aqueous environment. This proposed research aims to investigate the functionalized peptide-coated PtNPs as potential antitumor agents. We will use this combinatorial assay for the controlled formation of small PtNPs. The mechanism of nanoparticle formation will be extensively investigated, including full structural NMR analyses, thermodynamic and kinetic studies, all with the intention of providing insights into how the size-controlled PtNP formation is achieved. The major challenge will be to find the ideal, additive, peptide-based modification for specifically translocating PtNPs into the cancer cell nucleus. We believe that this potentially pro-drug will be inactive in the extracellular environment due to the presence of inert Pt(0) that will be oxidized by the high levels of hydrogen peroxide in cancer cells to Pt(II) ions. Therefore, in vitro cytotoxicity will be studied, as well as toxicity and metal accumulation in healthy cell lines to discover anti-cancerogenic peptide-coated PtNPs.

Mots clés : bioinorganic chemistry, chemotherapeutics

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187419.6 €
Projet RoyalCities (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Cities first developed in the fourth millennium BCE in Mesopotamia and quickly became the centers of civilization. Despite extensive work on urban landscapes from an archaeological perspective, these ancient cities remain poorly understood. Even less studied are royal capitals, the seats of kingship when empires emerged in the first millennium BCE. This project explores capitals from the two main, competing empires—Neo-Assyrian and Neo-Babylonian—to address key questions: what constitutes a royal capital and what distinguishes it from other important cities? How are capitals conceptualized by the kings who inhabit, establish, and renovate them? What are the effects of the kings’ presence in and patronage of the capital cities on the urban fabric and the social and economic structure of the urban population? By juxtaposing the Assyrian capitals in Assur and Nineveh with the Babylonian capital of Babylon as case studies, this research uses a novel comparative approach based on a methodology that combines philology, religious studies, and social and political history to answer these questions. Uniting materials from the highest levels of state such as royal inscriptions, decrees, and letters with administrative, economic, and private archives, and joining these textual records with archaeological evidence through the lens of royal patronage, this project employs an innovative holistic and interdisciplinary framework to reveal how the kings’ ideological and official relationships to their capitals affects the social and bureaucratic structures of these cities. The project capitalizes on the knowledge transfer between the researcher’s Neo-Assyrian specialty and the host institution’s Neo-Babylonian expertise. The project’s results have great potential to revolutionize our understanding of cities and royal power in the ancient world, and to make accessible a wealth of new data for fields as diverse as history, anthropology, sociology, urban studies, and political science.

Mots clés : assyria, babylonia, mesopotamia, capital cities, royal patronage

Participants :
- University of Vienna (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166156.8 €
Projet ReAgent (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Cities have to develop new ways to manage road infrastructures and vehicle flows to improve air quality. In the last decades, in the field of urban planning, many advances have been made, however the urban planning processes are still reliant on very traditional approaches that are very laborious and are highly dependent on intellectual processes. ReAgents focuses on urban modelling, and participatory simulation for future mobility to improve decision making and urban planning strategy in the Metropole de Lyon. The fellowship will be carried out at Unviersité Claude Bernard Lyon 1 (UCBL) under the supervision of Gilles Gesquiere deputy director of a national “Laboratory of Excellence” (LabEx) project entitled IMU (“Intelligence des Mondes Urbains”/ Intelligences of Urban Worlds). The experienced researcher will model and simulate the impacts of urban policies on traffic and air pollution emissions using agent based-models (ABM). These models will be displayed on a physical 3D model of the city, called tangible user interface (TUI). ABM coupled with TUI represents a radically new decision support tool for the different stakeholders of the Metropole de Lyon which can be used to explore and assess new urban planning strategies that meet citizens and stakeholders needs. The ReAgent project will reinforce the ER’s interdisciplinary research and transferable skills as well as its professional network in both the academic and private sectors since universities, public actors (including the Metropole de Lyon), associations and companies are involved as partners in IMU.

Mots clés : decision making, computational modelling, agent based model, tangible interface, smart city

Participants :
- Université Claude Bernard - Lyon 1 (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €