Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CRIME (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Criminal behavior presents a significant public health problem that involves heavy economic and social burdens, including the costs of criminal justice adjudication, compensation for victims and their families, and collateral impacts on communities. While there have been attempts to address this important topic, there are a number of limitations in other studies. Within the field of criminology, sociological perspectives have been the dominant explanation for criminal behavior for while biological factors have been largely ignored. Additionally, most of the criminological research has been based in the U.S., and criminological researchers who examine biological factors often need to rely on small, non-representative samples due to the lack of national U.S. databases containing relevant information. There have been attempts in Europe, mainly by psychiatrists and other medical professionals, to address crime-related questions by using available European registries; however, these projects examine familial transmission of genetic risks for psychiatric conditions, focus on specific subtypes of criminal offending, or utilized techniques that are considered outdated or rudimentary today. Lastly, much of the research has focused on male offenders and on offenders who engage in “street” crime (e.g., violent crime), with little attention paid to female offenders or less conventional forms of offending (e.g., white-collar crime). To overcome these limitations, this project will utilize Sweden’s national registries that allow for population-wide analyses and state-of-the-art statistical techniques to deepen the understanding of the role of biological (i.e., genetic) and social (i.e., environmental) influences in the development of criminal behavior (in general and by subtype), and how gender and socioeconomic status alter these biological and social influences. The proposed study will also examine the consequences of criminal behavior on subsequent life outcomes.

Mots clés : crime, criminal behavior, heritability, genetics, population based, national registry, big data

Participants :
- Örebro University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191852.16 €
Projet DiCrEd (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Critical editions of 19th-century Italian opera have been appearing in print for over four decades, offering the basis for productions in major European theatres, as well as for audio and video recording with world leading singers, which continue to engage millions of people today. Established in 1983, _The Works of Giuseppe Verdi_ (University of Chicago Press and Ricordi) aims to publish all of Verdi’s music in a critical edition, relying on the rigorous criteria developed by its Editorial Board, but the traditional printed book format of this edition presents several practical limitations for users: in particular, it does not allow for simultaneous visualisation of alternative materials and for fruition of alternative versions of the score, and it precludes addition of newly available source materials to existing volumes. DiCrEd is a multidisciplinary project aiming to address these limitations through the integration of the innovative instruments offered by digital humanities into _The Works of Giuseppe Verdi_, under the supervision of its general editor, Prof. Francesco Izzo (University of Southampton). DiCrEd employs the digital tools designed by the Edirom project (University of Paderborn) to develop 1) an applied model of digital critical edition with 2) an interactive system of fruition of the score, and 3) an applied model of digital critical edition of preparatory materials (sketches and drafts). The project uses Giuseppe Verdi’s French version of _Macbeth_ (1865) as a case study, making its full score commercially available for the first time. The project bears the potential to mark a turning point in the fields of musicology and textual criticism, with the long-term prospect of introducing digital instruments into the standard toolkit of the publishing industry related to 19th-century Italian opera.

Mots clés : digital critical edition, edirom digital tools, casa ricordi, giuseppe verdi, textual criticism, macbeth, opera rara, publishing and recording industry

Participants :
- University of Southampton (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet EpiPur (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Current epilepsy therapies, based on mediating excitation or inhibition have no impact on disease progression and are ineffective in over 30% of patients, demonstrating the urgent need for therapies with different mechanisms of action. An exciting concept is that increased hyperexcitability states and network changes are caused and maintained by a sustained glial activation.The ATP-gated P2X7 receptor (P2X7R), a gatekeeper of inflammation, has recently emerged as a promising target for epilepsy, showing anticonvulsant and disease-modifying properties in animal models. To bring P2X7R further towards a clinical application, however, important gaps in our understanding must be filled. Evidence for ATP release in the brain during seizures is currently lacking, the cell types involved in pathological P2X7R activation must be determined, and whether results from rodent models can be replicated in human tissue must be tested. Recent technical advances now bring the answers to these questions within reach. EpiPur brings together a team of experts in purinergic signalling, industrial partners specialised in the development of P2X7R antagonists and epilepsy clinicians. Biosensors will be used to record ATP in vivo with high sensitivity and temporal resolution; new transgenic mouse lines will be used to elucidate the subcellular expression and cell-specific disease contribution of P2X7R. Newly developed P2X7R antagonists will be tested in brain tissue resected from epilepsy patients. This highly interdisciplinary and intersectoral approach will add a significant contribution to the understanding of neuroinflammatory processes in disorders of the CNS. Further, the skills acquired during the research project, the excellent training record of the supervisor and host institution and the outstanding resources for learning and development available at RCSI will give me the tools necessary to achieve research independence.

Mots clés : epilepsy, drug refractory, atp signaling, p2x7 receptor

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet Smart Fishways (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Current society needs a large volume of fresh water to keep its present lifestyle. This has led to the massive installation of barriers in rivers, causing fragmentation of habitats and ecological alteration of freshwater systems. Fragmentation specially affects fish, as they require different environments to complete their life cycles. Stepped fishways are the most extended solution to ensure fish movements. Unfortunately, their efficiency is sensitive to the equilibrium between biological and hydraulic aspects, which, is often far from acceptable. The natural variability of rivers modifies the hydraulic conditions within fishways, affecting the biological responses and their principal objective: allow the free movement of fish. This research project aims to (1) assess the effect of hydrological variability in stepped fishways and for this (2) to develop a technological and methodological framework to monitor fishways performance in real time which combines fish biology, hydraulics and sensor networks. This will allow creating a new generation of smart fishways capable of self-deciding their optimal configuration when faced to hydrological uncertainty. The study of the effect of variability will allow to adapt and propose specific solutions to some of the challenges that need to be faced the coming years, such us accomplish the requirements or Water Framework (2000/60/EC), Habitats (1992/43/EEC) or Renewable Energy Directive (2009/28/EC), and will help to define solutions and actuation plans for the possible modifications in the water cycle produced by the climatic change, in line with EU Adaptation Strategy.

Mots clés : fishways, hydrological variability

Participants :
- University of Valladolid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160932.48 €
Projet TARNEPC (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Current treatment options for prostate cancer include use of androgen deprivation therapies to block tumor growth but often the tumors become castration-resistant. Even the second generation antiandrogens that do have significant effect on castration-resistant tumor growth in patients are not curative. Approximately 25% of prostate cancer patients with castration-resistant disease treated with antiandrogens develop a form of prostate cancer that is completely independent of androgen receptor signaling that fuels the tumor growth. Analyses of the pathology and genomics of these patient tumors has identified that the tumor cells adapt cancer stem cell and neuronal cell characteristics. Currently, there are no treatment options for this patient group. Thus, development of novel strategies including selection of drugs that could be used to reduce the tumor growth and metastases in this patient group are desperately needed. This project aims at characterizing a novel therapeutic target against aggressive, the treatment resistant neuroendocrine prostate cancer. The success of this project may significantly benefit prostate cancer patients and provide cost-effective therapy options to be utilized in health service.

Mots clés : cancer, prostate, neuroendocrine, treatment resistance, neuroplasticity

Participants :
- University of Eastern Finland (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202680.96 €
Projet AutoTADes (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Cyber-physical systems (CPSs) are everywhere, from autonomous vehicles to medical devices to smart buildings. Designing such CPSs that achieve complex tasks is a tedious and error prone process. During the design, high-level specifications describing desired functionalities, safety measures, physical properties and restrictions, and optimality criteria have to be considered. Furthermore, as people’s life may depend on CPSs, their correctness is of critical importance. This IF project aims at developing new theory and novel academic tools to make possible the design of such systems in an automated way from a set of given descriptions and specifications with optimality and correctness guarantees. In the era of CPSs, automating the design process is crucial. This project will investigate the design aspect focusing on subsets of Timed Automata (TA) as a modeling formalism and Metric Linear Temporal Logic (MITL) as a high-level specification language. The main objectives are (1) to generate the “optimal” timed automata from a parametric partial model by both tuning its parameters and synthesizing controllers at the same time, and (2) to develop a new framework for the automated construction of a partial TA from system descriptions and specifications. The optimization of this partial TA will be achieved by (1). The first objective involves combining two problems, namely optimal control and parameter synthesis for TA, that are currently studied separately in literature. Despite earlier un-decidability results, the parameter synthesis problem has been popular due to the expressivity of TA as a modelling formalism and difficulties in designing TA from complex specifications. This project aims at developing a new framework to generate optimal timed automata by exploring all design directions. This framework will be tested on a practical example that will be generated with an SME via the host organisation.

Mots clés : formal methods, timed automata, optimal control, parameter synthesis, linear temporal logic, automated construction, metric linear temporal logic, cyber physical systems

Participants :
- Middle East Technical University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 157845.6 €
Projet SCIENCzEch (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

CzechNight covers Researchers´Nights 2020 in the Czech Republic. The main objective of the Researchers' Night is to give citizens and local communities the opportunity to meet with researchers, learn about their passion for science, the motivation that inspires them, the methods they use, and the results they achieve. It opens doors to the places where scientists work and brings also research to unusual places. At this event young people and adults can get insights into what it is to be a researcher and what kind of cutting-edge technology is used in modern research The key objective of the event is to show research careers as interesting, enriching and useful job that might entail a career path for everyone and to motivate and inspire the youth to enjoy, understand and pursue science and technology. General people, families, teenagers and children will meet and talk with outstanding scientists, see new technologies and innovations and get answers to their questions about science, research and scientific career. It presents impact of science in everyday life, it shows new inventions, technologies and methods which we use in our everyday life, at homes, in the cities, at schools, in medicine, transport etc. The aim is to point out the importance and benefits of research for everyone. Moreover, the researchers will get new point of view and inspiration and generally, it will lead to new questions and answers at both sides.

Mots clés : european researchers  night, czech republic, human and robot

Participants :
- Technical University of Ostrava (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 150000.0 €
Projet DINEQ (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

DINEQ explores changes in the discoursal representation of degrees of economic inequality in selected British newspapers in 1971 and 2011. It is the first applied diachronic linguistic study to combine a consideration of the socio-political history in Britain in those forty years, a comparative analysis of selected public discourses in those two years, and a semantic, grammatical and lexical study of media representations of wealth inequality. The methodological approach used for this project is primarily Corpus Linguistic, but draws also on Systemic-Functional Grammar, and adopts a broadly Critical Discourse Analytic theory of discourse. The interdisciplinary nature of this project is complemented with the expertise of the Supervisor, Prof. Michael Toolan, and the Fellow, Dr. Eva Gomez, both experts in Stylistics and Discourse Analysis. The quality of the proposed project is ensured by the commitment of the members involved and the support committed by the University of Birmingham, one of the leading universities in Europe. This innovative study aims to demonstrate that rigorous and systematic corpus-based discourse analysis can establish discursive change over time, of a kind that is so dispersed and gradual that it is imperceptible in the day-to-day newspaper-reading of the ordinary reader.

Mots clés : discourse, economic inequality, british press, corpus linguistics, critical discourse analysis

Participants :
- University of Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet REAP (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

DNA damage-inducing platinum drugs, such as oxaliplatin and cisplatin, are used to treat about half of all patients receiving chemotherapy. Although potentially very efficient, many patients develop resistance for yet unrecognized reasons. Better understanding of the DNA damage response (DDR) to platinum-DNA lesions is therefore much needed for improving treatment outcomes. By performing DDR-dedicated CRISPR/Cas9 knockout screens, the applicant has shown that some cancer cells deficient in the major repair of bulky DNA lesions, global-genome nucleotide excision repair (GG-NER), are insensitive to oxaliplatin but sensitive to cisplatin. This striking difference remains as of yet unreported, but might explain differential responses of tumors to drugs. The aim of this proposal is to understand why GG-NER is unable to repair oxaliplatin lesions in particular genetic backgrounds. To do so, unbiased identification of genes differently mutated or expressed in oxaliplatin-sensitive versus insensitive cells will be followed by validation and in-depth functional characterization of identified targets. The ambition is to extrapolate experimental observations to translational knowledge. Validated targets will be studied in patient-derived tumor tissues as compared to nonmalignant tissues and related to patients’ treatment responses. Identification of genetic factors that regulate platinum lesions recognition by GG-NER will contribute to the understanding of molecular principles of platinum drugs cytotoxicity and might thus have considerable benefit on current cancer treatment schemes. The novelty of the pilot data, the unique multidisciplinary design of the project, the use of state-of-the-art molecular techniques and a collaboration with multiple European experts will ensure high scientific impact. Both, the applicant and the host will greatly benefit from the vital knowledge transfer. This project follows the European Union's commitment to cancer research.

Mots clés : dna repair, nucleotide excision repair, dna damage, platinum drugs, cancer

Participants :
- Medical University of Vienna (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 77569.6 €
- Austrian Academy of Sciences (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 108597.44 €
Projet RAGES (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

DNA double-strand breaks (DSBs) are highly toxic and must usually be accurately repaired to prevent oncogenic mutations. However, DSBs also represent necessary intermediates of recombination events required to create genetic diversity in immune repertoires and the germline. These distinct cellular contexts require that DSBs are differentially metabolised to achieve the required genetic outcome. Thus a complex system has evolved to regulate DSB repair. Rif1 was recently identified as a critical regulator of DSB repair, recruited to chromatin at DSBs by the 53BP1 chromatin reader. However, little is known about how these proteins cooperate to alter the chromatin landscape at DNA damage sites, and how this influences DNA repair decisions. Understanding the molecular basis of these proteins function is paramount, as misregulation at the level of Rif1/53BP1 is known to drive disease: loss of either protein results in primary immunodeficiency, while an inability to counteract Rif1/53BP1-dependent activities during DNA repair is associated with genomic instability that drives carcinogenesis. Interestingly, recent evidence suggests that Rif1 may also mediate gene-repression in certain chromatin contexts. This raises the possibility that the manner by which Rif1 regulates transcriptional control may be similar to its role in DNA repair. In this proposal, I seek to test my hypothesis that Rif1 mediates repressive chromatin states to regulate both transcription and DNA repair outcomes. My preliminary work and an array of unique cell lines and molecular reagents developed by my host laboratory, provide me with a unique and timely opportunity to examine this fascinating protein, and develop a better understanding of potentially common regulatory mechanisms that govern transcription and DNA repair.

Mots clés : rif1, dna double strand breaks, class switch recombination, chromatin architecture, transcriptional regulation

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet ICL CHROM (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

DNA interstrand crosslinks can arise as a by-product of cellular metabolism and, if left unrepaired, they impede DNA replication and threaten genome integrity. Faulty repair of DNA interstrand crosslinks has been linked to Fanconi anemia (FA), a disease characterized by genomic instability and cancer predisposition. The mechanisms underlying DNA interstrand crosslink repair are not fully understood, and it is likely that key regulators of this pathway have yet to be identified. Further, as the proteins involved in DNA interstrand crosslink repair have mostly been profiled using cell-free systems, the impact of chromatin states on DNA interstrand crosslink repair is poorly understood. The main aims of this project are i) to profile the entire repertoire of proteins recruited to DNA interstrand crosslinks in human cells, and ii) to uncover and characterize chromatin proteins involved in DNA interstrand crosslink repair. First, I will develop a pull-down technique to biochemically isolate chromatin surrounding DNA interstrand crosslinks and I will employ it to quantitatively characterise the full spectrum of proteins recruited to these lesions in human cells. This approach has the potential to uncover new regulators of DNA interstrand crosslink repair, including numerous proteins with a function in chromatin biology. I will, then, complement and expand this biochemistry-based strategy using a live cell imaging approach, with the aim of uncovering nucleosome remodellers and histone chaperones recruited to DNA interstrand crosslinks. Finally, the function of new regulators will be dissected using a combination of state-of-the-art microscopy and gene targeting techniques. Together, this work will provide a comprehensive picture of the proteins involved in DNA interstrand crosslinks repair and will uncover mechanisms of chromatin remodelling associated to the repair of these lesions in human cells.

Mots clés : dna interstrand crosslink repair, histone chaperones, chromatin remodelling, fanconi anemia, chromatin and epigenetics

Participants :
- University of Dundee (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €