Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet hRBP-virion (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

35 million people are currently infected with Human immunodeficiency virus (HIV), causative agent of AIDS. While cocktails of anti-retrovirals can reduce viral loading to undetectable levels, drug resistance can emerge due to the high-mutation rate of the virus. Moreover, no cure is yet achieved. Therefore, it is crucial to explore complementary therapeutic strategies, a challenge that H2020 prioritizes in health. The strict dependency of HIV on host RNA-binding proteins (RBPs) represents a potential step for intervention through host-based therapies, which can be more refractory to the evolution of resistance. In some sporadic cases, host RBPs have been shown to be incorporated into virions and impact downstream early steps of infection. However, no global and systematic studies aimed to determine the scope and biological significance of host RBPs selectively packed with the HIV RNA within the virions have been reported so far. The main goal of this action, referred to as hRBP-virion, is to address this important biological question by developing an unprecedented multidisciplinary approach that combines molecular biology and virology methods with next generation proteomics and data analysis. Hence, this pioneer approach will open new avenues of research in the field of viruses that have major health and socioeconomic impact and will enhance world-class basic and applied European innovation. The hRBP-virion project requires an exclusive mix of competences. I will bring research experience in RNA and molecular virology. My supervisor will train me in cutting-edge, system-wide proteomic methods. The host institution will provide state-of-the-art facilities and pooled expertise in a broad range of disciplines. Together these will create an excellent and unique cross-disciplinary atmosphere that will ensure the successful outcome of hRBP-virion and the appropriate transfer of knowledge among the participants.

Mots clés : rna binding proteins, protein rna interaction, interactome capture, aids

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet 3D-GATED (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

3D-GATED will focus on the utilisation of graphene in a unique and precise way, in combination with functional materials such as MoS2 and MoSe2 to address the specific demands of the sustainable energy sector, focussing on electrode development for the hydrogen evolution reaction (HER). Specifically, 3D-GATED will synthesise, optimise, and translate to a functional device; custom designed free-standing 3D graphene architectures through chemical vapour deposition (CVD) on complex Cu constructs. 3D-GATED addresses the need for reproducibility, low gravimetric density, and long range conduction in electrochemical device electrodes. This will be achieved through a convergence of research progress; improvements in selective laser melting (SLM) of Cu; CVD of graphene on Cu; delamination of graphene from Cu; and doping of graphene with functional materials. Growth of 3D graphene on Cu constructs will be analysed for quality and homogeneity using Raman spectroscopy (and mapping), x-ray spectroscopies, and electron microscopy. Exfoliation of graphene from the Cu constructs will be studied though chemical etching and electrochemical delamination. The free-standing 3D graphene architectures will be doped with functional materials before being analysed for suitability as electrochemical devices. Additional focus will be given to utilizing the synergistic effects of the 2D catalytically active materials, MoS2 and MoSe2, with graphene to form fully functional device architectures for the HER. 3D-GATED will make major advances in the use of graphene template materials for electrochemical devices, propelling the integration of these devices into the commercial sphere through Imperials diverse commercial partners.

Mots clés : graphene, electrochemical devices

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet 4D-POLYSENSE (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

4D-POLYSENSE project aims to contribute to the European Research Area (ERA) by developing a new generation of surgical meshes able to interact with the complex three-dimensional (3D) structure of biological tissues, as a smart material working as self-evolving motion sensor. Polypropylene (PP), one of the most widely employed polymers so far for surgical implants, will be modified by plasma technique to confer it temperature sensitivity upon deposition of a biocompatible hydrogel. Afterwards, it will be sterilized following a quite novel route with supercritical carbon dioxide (considered a "green solvent"), a technique chosen in order to prevent damage of the thermoplastic substrate and the hydrogel structure. 4D-POLYSENSE proposes the use of 4D printing strategy to obtain meshes that will be able to dynamically interact with local environment, after a specific stimulus. Plasma and biological assays will be performed at the secondment host, B Braun Surgical S.A., which is the leading European company of healthcare products. The partner will be relevant for the experienced researcher (ER) training on medical field and on her international mobility to company headquarters. The project is intended to: (i) enhance the creative and innovative potential of the experienced researcher (ER) in a multidisciplinary project, involving a combination of well-developed chemistry, bioengineering, microbiology and additive manufacturing; (ii) create opportunities for the ER mobility and her knowledge transfer to the host groups, as well as forging her future collaborations in the aforementioned fields; and (iii) increase the competitiveness in Europe launching to the global market an innovative product, an abdominal hernia repair, demanded by the medical community. Moreover, an ambitious training program including a number of new scientific and soft skills to be transferred to the applicant is also envisaged.

Mots clés : 4d printing, polypropylene surgical mesh, motion sensor, plasma functionalization, smart material, sterilization with carbon dioxide

Participants :
- Universitat Politècnica de Catalunya (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 158121.6 €
Projet Rmat3 (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

A "quiet revolution" is occurring at the "border between atomic physics and experimental quantum chemistry" (Annu. Rev. Phys. Chem., 2014, 65, 501-518). Techniques for producing cold and ultracold molecules are enabling the study of chemical reactions and scattering at the quantum scattering limit with only a few partial waves contributing to the incident channel leading to the observation and even full control of state-to-state collisions in this regime. Rmat3 will develop a new formalism and allied codes for tackling problems for triatomic molecules involving low- and ultra-low energy collisions. Though this project focuses on triatomics, the formalism is completely general and could prove transformative in its scope. It is particularly appropriate for slow collisions occurring over deep wells. The many resonance states make such systems hard to treat theoretically but offer the best prospects for novel physics: resonances are being widely used to control diatomic systems and should provide the route to steering ultracold reactions. Rmat3 will build on the progress made in variational calculations of molecular spectra by using these methods to provide rovibrational wavefunctions for the whole system at short internuclear distances. These wavefunctions will be used to construct collision-energy-dependent R-matrices which can then be propagated to give products as a function of collision energy. The methods will be used to study ultracold collisions in triatomic systems in conjunction with leading European experimental groups, focusing on the H2O and H3+ systems for which spectroscopically accurate potential energy curves are already available. The project will focus on elastic and inelastic collisions and reactive scattering.s The new methodology explored in Rmat3 can be extended in the future to treat larger molecular systems as well as photodissociation and photoassociation, charge exchange and predissociation. The Rmat3 code will be made freely available to the scientific community.

Mots clés : cold molecules, scattering, collisions

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet ARCHPRIS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

A Prison Farm (PF) is a correctional facility located in rural environments where inmates are employed in open-air manual work.Within the current European carceral archipelagos, mostly constituted of mass urban walled prisons and recent suburban super prisons, PFs are limited in number and scope and often disregarded by national and EU policies, and by academic studies. Yet, PFs show potential in addressing the EU's wills to: improve the current state of incarceration while reducing its scope; promote sustainable agriculture and rural development. The IF's objective is to tackle these 2 societal challenges with a pilot project for a network of detention farmhouses that will be tested in the territorial condition of Flanders, a EU region suffering from an increase loss of farms. The project adopts a research-by-design methodology and will follow a groundwork comparative study of the space of selected existing PFs in Belgium, Italy, and Finland, aiming at the acquisition and systematization of a currently missing knowledge on European PFs. The project will be based -while extending its scope to the rural condition- on the cutting-edge institutional model elaborated by the NGO De Huizen, whose proposal for a network of urban small-scale contextually integrated detention houses is challenging the current penal system in Belgium. The supporting network of the host and partner institutions (KU Leuven-Dept.of Architecture, VUB-Dept.of Criminology, De Huizen), and of key members from Belgian public authorities in the sectors of prison and rural development, constitutes a unique interdisciplinary milieu of knowledge and expertise that will guarantee the success of the IF.This will impact the fellow's career, evolving her expertise in the field of prison architecture while expanding her critical insight on broader theoretical themes around the empowerment of architecture in directing human behaviour and the relationship between architecture-institutions-large scale territory.

Mots clés : architecture and institutions, prison architecture, prison farm, rural development, territory, flanders

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 178320.0 €
Projet CLARITY (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

A consistent picture of climate variability is pivotal for understanding its evolution. CLARITY intends to apply advanced statistical methods developed in the field of statistical physics to analyze, interpret and incorporate into modelling strategies observed, reconstructed, as well as simulated climate data. To achieve this ambitious goal valuable information from fluctuations in climate records will be uncovered. The obtained results will constitute the input for a Bayesian modelling strategy, aimed then at improving modelling reliability. Once operational, this approach will be applied to a series of climatically relevant issues. On a local scale (city of Venice, Italy), particularly, climate records related to temperature, humidity and the ultraviolet radiation exposure of city’s school populations will be collected and used to obtain projections that can be of assistance to community needs. CLARITY represents a pilot research that integrates reconstructions, observations, simulations and applications at the local community level. It will extend climate investigations through the application of methods of statistical physics in an academic environment internationally recognized for its expertise in the field of climatology.

Mots clés : complex climate, fluctuation analysis, bayesian modelling, local uvr exposure

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet NOMAD-Outcome (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

A decade after the outbreak of the 2008 financial crisis, affordable housing-related displacement has become a global problem. Although displacement has captured the attention of urban sociology, social resistance to it remains understudied. The aim of this project is to fill this gap and explain the diverse outcomes of neighbourhood-based mobilisations opposing displacement through a qualitative comparative analysis of three cases (Parc-Extension in Montréal, Poble Sec in Barcelona and La Guillotière in Lyon). The research will shed light on three types of outcomes: favourable media coverage, social recognition and influence of public agenda. The project builds on the assumption that the capacity to generate outcomes depends on collective action mechanisms: the diversification of protest tactics, the forging of wide coalitions and the desingularisation of the idiosyncratic experience of the neighbourhood. Another aim of the project is to produce an oral history archive of the three neighbourhoods, which will contribute to foster knowledge transfer between academia and society. This GF proposes: a) an outgoing period to Centre Urbanisation Culture et Société (INRS) in Montréal, where I will be involved in a multidisciplinary research group (Tryspaces) and I will receive theoretical and technical training; b) a secondment in Institut de Govern i Politiques Publiques (UAB), in Barcelona, where I will pursue training activities; c) a return period in Centre Max Weber (Université Lyon 2), in Lyon, where I will transfer the acquired skills and develop additional training to enhance my career prospects. My profile being based on comparative politics and social movement sociology, the GF will provide me with a new interdisciplinary expertise in urban studies, critical geography and audio-visual and multimedia techniques, as well as a deep knowledge of international research funding procedures and research-leading skills ready to be used in France.

Mots clés : social movement outcomes, urban displacement, neighbourhood mobilisations, oral history

Participants :
- Université du Québec (Canada) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Lumière - Lyon 2 (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 262385.28 €
Projet MeGa (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

A fundamental aspect of biology is the understanding of how cell fates are established and maintained. Although it is widely accepted that epigenetic reprogramming is a central process of mammalian development, one of the most intriguing questions that remains unanswered is how DNA methylation marks contribute to cell differentiation and lineage commitment. By combining, novel single cell genomics techniques, CRISPR/dCas9 technology and innovative analytical approaches, this project will uncover the links between DNA methylation, gene expression and cell fate decisions during mouse gastrulation. This information will be used in a novel way to identify methylation signatures responsible for the stable repression of pluripotency, which has great potential to advance the development of safe iPS cells. Furthermore, this proposal will implement two innovative approaches utilising single cell DNA methylation patterns to reconstruct lineage trajectories of individual cells. This project capitalises on the unique combination of my novel analytical approaches, my background in DNA methylation analysis and evolutionary biology together with the extensive expertise in single cell techniques and developmental biology of the host lab. This multidisciplinary proposal will provide critical insights into how information is encoded in the epigenome and what this information can tell us about a cell’s history within a developing organism. These results will significantly advance the field of epigenetics, developmental and stem cell biology. Finally, the knowledge and skills gained from this project combined with my scientific and personal development will hopefully open up exciting career possibilities with the long-term goal to establish my own research group in Europe.

Mots clés : dna methylation, single cell genomics, mammalian development, epigenetics, gene regulation

Participants :
- UK Research and Innovation (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 195454.8 €
Projet VOLIV (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

A fundamental property of animal cells is the ability to maintain their volume constant to face changes in osmolarity and during division, migration and transepithelial transport. There is emerging evidence that cell swelling also initiates signaling cascades that regulate metabolism, particularly in hepatocytes. However, the basic mechanisms responsible for sensing volume changes and initiating volume-regulated signaling cascades in the liver remain largely unclear. As major player in cell volume regulation, the Volume-Regulated Anion Channel VRAC may influence liver metabolism by controlling hepatocyte volume. VRAC was recently identified by the host laboratory as LRRC8 heteromers. LRRC8A represents the obligatory subunit and forms heteromers with LRRC8B-E isoforms. Depending on the subunit composition, the heteromers present specific electrophysiological properties and transport different substrates. The aim of this proposal is then (i) to investigate the role of VRAC and its different subunits in liver function and particularly (ii) as signal transducer between hepatocyte volume and metabolism. The host laboratory already generated numerous LRRC8 mouse models e.g. tagged-Lrrc8 knock-in mice which are valuable tools to determine the subcellular distribution of the different LRRC8 subunits in the liver. I will also develop hepatocyte-specific knock-out (KO) mice to analyze the liver histology and function. Primary hepatocytes from the different KO will be used to study the potential roles of VRAC in liver physiology at the cellular level e.g. via autocrine signaling cascades. I finally intend to identify the VRAC-dependent hepatic metabolic pathways using large-scale analytical techniques and evaluate the systemic metabolism of the different KO mice. My project is expected to uncover the role of VRAC in liver physiology from molecular to systemic level and thus to provide detailed insights of the molecular coupling between hepatocyte volume and liver metabolism.

Mots clés : vrac, cell volume, hepatocytes, metabolism, autocrine pathway

Participants :
- Max Delbrück Center for Molecular Medicine (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 159460.8 €
Projet PULSE2D (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Atomically thin layers of transition metal dichalcogenides (TMD) are gaining increasing attention as new materials for future Beyond-CMOS electronics. Recently, a great progress has been made in deposition of high quality layers of TMDs paving the way towards wafer scale device manufacturing. However, many fundamental and technological challenges still have to be addressed. Precise tuning of the number of layers, doping, surface functionalization and selective low damage etching of TMDs are among the most critical technological steps. Plasma processing is an enabling technology used for doping, etching and deposition of ultrathin layers in microelectronics industry. However, the application of plasmas for integration of 2D materials remains marginal and poorly controlled. The major challenge for plasma treatment of atomically thin materials is the need for unprecedented control of fluxes and energies of plasma species at the substrate. Pulsed plasma technology holds promise of reaching conditions required for low damage processing of 2D materials with a single atomic layer precision. The ambition of PULSE2D is to develop highly controlled pulsed-plasma technology for integration of TMDs in nano-electronic devices on a wafer-scale. A fundamental study of the mechanisms of interaction between pulsed plasmas and atomically thin TMD materials will be performed. Defect production, adsorption and etching processes will be quantified as a function of plasma parameters. This information will be used to perform atomic layer etching, functionalization and defect healing of TMDs using pulsed plasmas. The research and training activities will enhance technical skills of the candidate in the emerging area of plasma processing of 2D materials, industry-relevant nano-fabrication and measurement of TMDs transport characteristics. High fundamental and technological interest and timeliness of this subject will provide a powerful thrust for the future research career of the candidate.

Mots clés : transition metal dichalcogenides, 2d materials, pulsed plasma treatment, doping, atomic layer, etching, defect healing, ion energy control, high k dielectric gates, atomic layer deposition

Participants :
- IMEC (Belgique) — Coordinator, beneficiary, Recherche, subvention : 160800.0 €