Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet THREATS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Renewable energy developments are essential to fighting climate change but we do not yet fully understand their global spatial patterns and impacts on biodiversity conservation. Moreover, they could interact with other human pressures that are already threatening wildlife species. Understanding these interactions, the underlying factor triggering these threats, and their effects on protected areas, especially in areas where more threats overlap, would help us better prioritize and optimize efforts to break free from fossil fuels while also halting the loss of biodiversity. Therefore, this project aims to improve our current knowledge of the threats that renewable energy developments represent to biodiversity and to explore and advance our understanding of the interactions with other human-induced threats to biodiversity. This project will map for the first time, the likelihood of impact of all renewable energy developments using the International Union for Conservation of Nature Red List of threatened species for amphibians, birds, and mammals. Together with other threat maps (agriculture, afforestation, overhunting, invasive species, pollution, and climate change), obtained from peer-reviewed public sources, this project will identify and assess the interactions between threats through a co-occurrence matrix, and identify areas where more threats overlap. Finally, it will evaluate the socio-economic factors that are triggering all these threats and their effects on protected areas in two contrasting regions, Europe and South America. This project will promote a link between conservation and energy developments, providing relevant information to nature policies, which is both timely and urgent, as human impacts have become catastrophic on biodiversity. It will also have a substantial impact on my career, as new skills in ecological modelling and global threat assessment will complement my previous experience in human-induced threats and conservation biology.

Mots clés : human induced threats, birds, mammals, amphibians, landscape ecology, iucn red list, threats interaction

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet GRPSTABQIT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

The main focus of the project will be on stability properties for groups and their connections with quantum information theory. Intuitively, the term stability refers to the phenomenon of when approximate properties are "close" to actual properties. Concretely, the project will introduce for the first time stability with respect to quantum groups, and provide a systematic approach towards different important notions of stability for various classes of groups, notably "graph product-like" groups and amenable groups. For the latter, stability is also connected to character theory and dynamical systems, which will allow for different techniques from these areas to be applied towards our results.

Mots clés : hilbert schmidt stability, permutation stability, quantum groups,  graph products of groups, character theory of amenable groups, quantum information theory

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet THAIS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The period of Greek colonisation between 900 and 500 BC was one of the most formative periods of classical antiquity. Historical and archaeological research has greatly informed our understanding of this era, but the exact nature and demographic impact of the colonisation process remains unclear. The THAIS project will shed new light on this process by combining existing archaeological evidence with new ancient DNA data based on the analysis of human skeletal remains from four archaeological sites in Southern Italy, one of the focal points of Greek colonisation. Using archaeological and molecular lines of evidence, the project will address the following objectives: 1) reconstruct the genetic ancestry and kinship structures of the local Italic population in southern Italy; 2) investigate the origins of the Greek colonists at two colonial sites (Metaponto and Siris); 3) assess nature and demographic impact of the Greek colonisation by investigating possible admixture processes and sex-biased migration, and 4) investigate the genetic legacies and lasting health impact of the Greek colonisation in Southern Italy. The THAIS project will be the first to use ancient DNA analysis to study the impact of the Greek colonisation and together with archaeological lines of evidence will provide new information on the colonisation process and the interactions between the colonists and the indigenous Italic population at a key moment in Mediterranean history.

Mots clés : ancient dna, greek colonisation, antiquity, southern italy, migration, beta thalassemia

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet DRUG-SPIN (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Half of the globe’s population takes at least one drug a day. Since 90% of currently developed drugs exhibit poor water solubility, leading to exceeding amounts of drugs being consumed and unprocessed drug ending up in waste water. This project aims to address the challenge of poor water solubility in pharmaceuticals, improving the drug’s efficacy and patient compliance. By converting crystalline drugs into their amorphous forms, the solubility is known to increase by a large factor. However, based on the strategy for to obtain the amorphous form, drugs are more or less stable and crystallize in storage. This project will adapt an established method from materials science, melt-spinning, rapidly quenching molten drugs on a spinning copper wheel to achieve reproducible, high cooling rates and perfectly stabilize the amorphous state. The project has four key objectives. First, a melt-spinning device will be set up for drug quenching. This will involve designing and building the necessary equipment to achieve controlled quenching rates. Next, the project aims to produce amorphous drug particles or films, exploring the relationship between quenching rates and drug stability. The third objective is to characterize the stability and solubility of these amorphous drugs using advanced analytical techniques such as spectroscopy, calorimetry, and diffraction methods. Finally, the solubility and stability of these amorphous drugs will be assessed over an extended period. The project is expected to significantly advance the understanding of amorphous drug formulations, potentially leading to more effective and stable drugs. This research will contribute to reducing pharmaceutical waste and improving patient compliance, aligning with global sustainability goals. Furthermore, the fellowship will enhance my career prospects by providing expertise in pharmaceutical technology, thereby bridging the gap between materials science and life sciences.

Mots clés : pharmaceutic technology pharmaceutic processes

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 197544.96 €
Projet PhotoAntiMic3DP (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

It has been an ongoing requirement for humankind to access useful objects or to provide the missing part of damaged products. 3D printing (3DP) has become popular by completing these deficiencies in a very short time and low cost. Its many derivatives are available, however, it is a necessity to choose suitable modules and inks that fulfill the needs of in today’s world. Energy consumption of the world is increasing rapidly and this concept should be carefully considered in every step to be taken from social life to industrial life. Thus, light-induced 3D printing (L3DP) stands out with its features such as using clean energy source, high resolution and accuracy. Nonetheless, substantial effort is necessary to identify and put into action suitable photochemical interactions for this objective. Significantly, the selection of these interactions must be carried out carefully since the resulting materials should meet other contemporary demands; such as Recyclability. Dibenzazapine (DBA) and triazolinedione (TDA) are important molecules capable of giving light-induced reactions. Their reversible reactions with light and buffer solutions offer them the advantage to form degradable products and they can be promising candidates for L3DP. On the other hand, following the impact of COVID-19, the medical industry has reached a pivotal moment where the significance of antimicrobial materials has been better understood. However, the developed materials cannot keep up with the resistance rate of microbes and different combat strategies are necessity to cope with them. Antimicrobial photodynamic therapy (aPDT) is method which is utilized the interaction between photosensitizer (PS) and light, and it can be strong alternative for this purpose. In this context; zinc phthalocyanine as photosensitizier will be incorporated into 3D materials to obtain degradable photoantimicrobial properties thanks to DBA and TAD photochemical reactions.

Mots clés : light induced 3d printing, photodynamic antimicrobial therapy, phthalocyanine, dibenzazepine, triazolinedion

Participants :
- Helmholtz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
Projet NKT-in-NDD (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Neurodegenerative diseases (NDDs) are a broad category of neurological maladies, typically characterized by cognitive decline and motor deficits. NDDs affect over 55 million individuals worldwide, a number that is expected to triple over the following decades. Until recently, the brain was considered immune-privileged, but emerging scientific advancements in the field of neuroimmunology show that immune cells reside within and even infiltrate the central nervous system (CNS). Despite ever-growing evidence illuminating the critical interplay between the nervous and immune system in maintaining neural homeostasis, research efforts have been limited in this scope.  We recently identified that an immune-related gene, CD1d, is expressed by neurons. CD1d is recognized by natural killer T (NKT) cells, generally inducing an immunosuppressive response. We found that selective knockout of CD1d in neurons led to NDD development in mice. We also gathered biocomputational evidence from both human and mouse brains showing that neurons near the choroid plexus have the highest CD1d expression. These preliminary findings inspired the NKT-in-NDD project with the following three aims:  (1) To determine whether CD1d-expressing neurons can sufficiently activate NKT cells (2) To examine the impact of CD1d-dependent neuronal activation of NKT cells on inflammatory conditions and NDDs (3) To verify whether CD1d is expressed by neurons localized near the choroid plexus As an expert in neurological maladies, I will join forces with Prof. Shohreh Issazadeh-Navikas, a leader in the neuroimmunology field, to tackle this interdisciplinary project at the Biotechnology Research & Innovation Centre (BRIC) at the University of Copenhagen (UCPH) in Denmark. Together, we will address various gaps in the fields of immune cell biology, neuroimmunology, and neurodegeneration. The neuroimmune insight developed from this project may expand current treatment options for NDDs.

Mots clés : neuroimmunology, neuroinflammation, neurodegeneration, natural killer t cells

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 247553.28 €
Projet HyperK (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

As the primary risk factor for the onset of cardiovascular disease, hypertension is a major contributor to premature death and disability. High dietary sodium (Na+) consumption is often considered a primary culprit for hypertension, but evidence exists that increasing dietary potassium (K+) consumption may lower blood pressure (BP). However, a number of studies in humans indicate that higher K+ intake is not always beneficial for blood pressure – effects that the host lab recently confirmed in rodents. Reducing and maintaining a lower BP based on dietary intervention requires understanding of the long term and/or accumulated effects of the intervention and the underlying molecular basis. This project will increase our understanding of the differential effects of dietary K+ on BP, the role of the kidney and potentially the vasculature. The project objectives are to: 1) determine the optimum dietary K+ intake that reduces and sustains lower BP; 2) identify factors in the kidney that drive K+ sensitivity of BP; 3) assess if sustained high dietary K+ intake changes vascular function; 4) investigate the molecular basis of any vascular remodelling that promotes, or is consequential, to increased BP during prolonged high dietary K+ intake. To address these questions I will apply a broad range of interdisciplinary skills and methods: telemetric monitoring of BP, in vivo assessment of kidney and vascular function in animal models and gene modified mice, RNA sequencing (including single-cell) and bioinformatics, optical clearing and innovative 3D multiplex imaging of tissues. Successful completion of the research in this proposal provides an excellent opportunity to uncover new targets and strategies for the management of hypertension. From a personal perspective it represents a major step towards establishing myself as an independent researcher in the area of renal-vascular crosstalk.

Mots clés : hypertension, potassium, dietary intervention, kidney, vascular, 3d imaging

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet HYDRO-CLUSTER (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Modern computational chemistry methods are helpful tools for interpreting experimental and field measurements. The proposed HYDRO-CLUSTER project uses quantum-chemical calculations to provide molecular insight into the effect of humidity on molecular cluster formation in the atmosphere. These atmospheric clusters may grow in size and form aerosols, tiny particles dispersed in the air that hugely impact climate and human health. Water vapour is known to vary the particle formation rate. However, the presence of water molecules in the initial steps of new-particle formation (NPF) is not well understood, as very few theoretical studies on this topic have been published. On one side, hydrated molecular clusters become larger in size, and thus their collision with other molecules is more probable. On the other side, the cluster stability can be either lower or higher, complicating the fragmentation/evaporation of hydrated clusters. Current theoretical models can be several orders of magnitude wrong in predicting NPF rates as they do not account for the effect of water properly. In this project, configurational sampling of micro-hydrated acid-base clusters will be performed to reveal molecular insight into their thermodynamic stability. Machine-learning models for quantum systems will enhance both configurational sampling and molecular dynamics simulations, allowing us for the first time to reveal the role of water in cluster formation. Finally, we will model the effect of humidity on the atmospheric NPF and suggest a methodology for improving global climate models.

Mots clés : machine learning, quantum chemistry, micro hydration, configurational sampling, new particle formation, atmosphere

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 216782.4 €
Projet 4TopAndMore (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

At the Large Hadron Collider (LHC), protons are collided at the highest possible energy to generate subatomic elementary particles. We use the results of these collisions to understand our universe at the most fundamental level. Many theorists believe that new physics exists at a very high energy. The top quark is the heaviest elementary particle known to date with unique properties. It is therefore naturally suspected to have hidden connections with new physics. The simultaneous production of four top-quarks (tttt) is the most energetic process accessible with the LHC, making it a unique place to search for heavy new physics, which are less likely to appear elsewhere. The first evidence of these extremely rare events was only revealed last year, and we know very little about them. With the world-record energy at LHC Run3 (13.6 TeV), we expect 20% higher tttt events production rate. This offers a timely opportunity to further study this process. With an aim to find new physics, we will study tttt events in unprecedented detail with the ATLAS experiment at the LHC. We will measure the inclusive production rate and the kinematic properties of these events. We will use the measured results to probe new physics, with unique approaches that do not rely on new physics predictions made upon specific assumptions (which could be wrong). The results have the potential to reveal new physics that are too energetic and beyond the reach of the LHC. This will be the first time this is done for tttt events. The measured tttt event kinematics will be corrected to remove effects from the detector resolution and acceptance. This allows theorists to directly test their new physics predictions against the experimental results, continuously generating impact in the relevant scientific community. We will combine the results of tttt events with those of other types of events containing top quarks to build a global picture of the top quark in terms of its subtle connections to new physics.

Mots clés : top quark four top quark production new physics atlas lhc

Participants :
- Institute for High Energy Physics (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet UPI (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

“Understanding Psychological Impossibility” (UPI) will develop the first systematic account of psychological impossibility. To do this UPI will innovatively combine philosophical theorizing with empirical results from experimental philosophy, and the cognitive and brain sciences. In three work packages it will develop an 'a priori' account of psychological impossibility (WP1), examine this account using the methods of experimental philosophy (WP2), and then based on these results and normative considerations, such as whether the concept could issue discriminatory or prejudiced judgments, engineer a final account of psychological impossibility (WP3). UPI will radically improve our understanding of the relationship between people’s options, freedom, and moral responsibility, and provide the theoretical resources for ethical decision making when faced by people who have different affordances for choice and action. Understanding the way in which people do, or do not, shape their psychology with respect to psychological impossibility will advance our understanding of what happens when things go wrong, and when people develop psychologies that they do not want. Further, while our psychological impossibility judgments can do a lot of good, shaping our psychologies in a manner that is aligned with the true and good, they can also do a lot of harm. By understanding why we issue the psychological impossibility judgments that we do, we can then revise that understanding so that we do not prevent people from having access to equal opportunities to pursue their interests and the capacity to develop the kind of psychology that they want.

Mots clés : experimental philosophy

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet Orige.net (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In the ancient world, knowledge production was based on the use of quotations, so much so that scholars commonly refer to it as 'quotation culture.' This culture of quoting extended across various ancient civilizations, including Greek, Near Eastern, Hebrew, and Chinese societies. Early Christian communities were no exception, as their theologies were drawn from the biblical texts. Analysing their citation patterns is essential in unravelling their thought processes. My project aims to redefine our understanding of early Christian quotation culture by employing digital network analysis (NA) techniques applied to the extensive works of the renown theologian Origen of Alexandria (3rd century). Origen's focus on biblical interpretation and his enduring influence makes him an ideal case-study. I will conduct an analysis of Origen's whole corpus using NA graphs and social network analysis, thus uncovering relationships and patterns within his biblical quotations. By looking at Origen’s use of biblical quotations as sets of interconnected relations, the project seeks to investigate how he derived his theological doctrines – particularly his doctrine of religious freedom – from the Bible. The proposed NA methodologies have never been applied to ancient texts, representing a groundbreaking approach that opens new research directions into the study of quotation culture. This innovative methodology holds promise not only for the study of early Christianity but also for a wide range of text-related disciplines. In collaboration with AU Department of Theology and the Centre for Humanities Computing (CHC), the project will achieve two objectives. O1: Develop a novel digital approach for studying quotation culture, resulting in the creation of an open-access and open-source custom-built graph database for visualizing clusters of biblical references in Origen’s work. O2: Explore the concept of religious freedom in Origen's work using the newly developed NA methodology.

Mots clés : origen of alexandria, early christian studies, quotation culture, theology, digital humanities

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €