Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet M6Abolic-RNA-duplex (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

In the current paradigm of gene expression, the structure of messenger RNA (mRNA) is a key element of posttranscriptional control because it modulates interactions with RNA-binding proteins (RBPs). RBPs typically recognize RNA-binding domains to form ribonucleoprotein complexes that ‘commit’ mRNAs to specific functions, and mutated or deregulated RBPs are implicated in multiple neurodegenerative diseases and cancer. Yet, the knowledge on the dynamic regulation of ribonucleoprotein complexes in mammalian cells is limited, mostly because the ‘structure’ and ‘specificity’ of RNA-protein interactions are amply unexplored. Recently, the host laboratory developed a new technique – hiCLIP – which identifies the transcriptome-wide RNA secondary structures (RNA duplexes) bound by particular RBPs, paving the way for pioneering research on the ‘structural determinants’ of RNA function in mammalian cells. In this context, N6-methyladenosine (m6A) is the most prevalent internal modification in mRNAs with critical functions in RNA stability, and seminal studies recently showed that m6A ‘marks’ destabilize in vivo RNA duplexes in the mammalian transcriptome. However, i) how m6A ‘marks’ regulate RNA-protein interactions that rely on RNA secondary structures is unknown, and ii) there is no systems-level elucidation of which RBPs are sensitive to m6A. Importantly, the ‘maintenance’ of m6A levels requires metabolic substrates and the m6A protein machinery is implicated in obesity and cancer. Collectively, these evidences point to a structural role of m6A in RNA function, and raise the compelling notion that metabolic control of m6A may represent a ‘regulatory module’ of gene expression in mammalian cells. The research proposed herein is designed to reveal the ‘regulatory principles’ of RNA structures in cell physiology, and the prospective results are likely to provide far-reaching insights on the significance of this process for metabolism-related diseases and cancer.

Mots clés : metabolism, rna structure, rna binding proteins, rna methylation, cellular transformation

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet ExuNutriStress (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

In the face of global changes, agroecosystem productivity is essential both for CO2 fixation and feeding the increasing population. However, plant growth is frequently limited by nutrient availability and in the environment, plants are more often exposed to multiple than single nutrient deficiencies. Plant responses to single nutrient deficiencies have been widely studied while the combined effect of different nutrient deficiencies has been scarcely investigated, particularly for tree species. Root exudates comprise a complex mixture of organic compounds, directly involved in the biogeochemical cycles of nutrients in soils, it can be assumed that their quantity and quality are affected by combined nutrient deficiencies in a different way than under a single one. Thus, this proposal aims to profile Poplar (a fast-growing tree) root exudates under single and combined deficiencies, mainly focusing on: (1) N for macronutrient deficiency as the most often limiting nutrient and on Fe, Zn, and Mn as micronutrients because of their crucial role in photosynthesis, (2) experiments on mineral deficient calcareous soils close to agronomical situations and (3) testing the potential of Poplar root exudates to alleviate nutrient deficiencies in sensitive species such as fruit trees growing on calcareous soils. The applicant has a very strong background in soil chemistry and plant nutrition acquired during her MSc and Ph.D., which together with the experience and facilities of the host and the international supervisory team will lead to the successful completion of this project and the strengthening of the career development of the researcher. The interdisciplinary work involving plant physiology, metabolite profiling, and chemoinformatic tools will lead to (1) improve knowledge about root exudation under nutritional stress and (2) open a new perspective on root-root interactions that can improve plant nutrition.

Mots clés : nutritional stress, root exudates, poplar, calcareous soils, root root interactions

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 184707.84 €
Projet TICASS (Horizon 2020, appel à projets 2016)
Action : Staff Exchanges
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

In the face of images’ proliferation in all areas of human life, we can talk about the necessity of education on how to adjust to and operate in visual space, to read even and develop the language reflecting such culture. In response to the above mentioned social challenges, we have developed a subject of our scientific interest, which is reading images in spaces of transfer (mobility) of people in urban visual environment and across different cultures. We want to conduct our research at the airports, in trains and on metro stations, in parking lots, elevators, corridors (at the academies and universities, but also in tunnels), and in public transport (buses, trams, cabs and underground). The main problem is that in educational programs there is a lack of teaching students how to read and interpret visual communicates present in social spaces, which is indispensable for culturally developed and conscious communication on a global scale. Therefore, we have to realize the TICASS project to introduce into educational programmes visual literacy and to contribute to the development ofawareness of cultural specifics of visual literacy in business. The project will be realized by means of secondments between European and African Partners, during which we will conduct seminars, trainings,workshops, research and elaborate artistic exhibitions. There will be also delivered reports on education and three anthologies. The project on technologies of imaging is an unprecedented within social sciences and humanities, because in educational programs there is no teaching how to read and interpret visual communicates present in social spaces. The research outputs will be shared also with market representatives, because the analysis of meanings and ways of functioning of images and technologies of imaging in different coutries can serve also conscious business (media, IT, design, creative industries).

Mots clés : technologies of imaging, iconosphere, urban space, digital imagery, scientific images

Participants :
- University of the Witwatersrand (Afrique du Sud) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Jan Evangelista Purkyně University in Ústí nad Labem (Rép. Tchèque) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 153000.0 €
- Pwani University (Kenya) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Polish University Abroad (Royaume-Uni) — Partner, beneficiary, Recherche, subvention : 126000.0 €
- Szczecin Academy of Arts (Pologne) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 117000.0 €
- University of Macerata (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 99000.0 €
- Stowarzyszenie edukacja, nauka, kultura (Pologne) — Partner, beneficiary, Autres, subvention : 135000.0 €
Projet AMBEATion (Horizon 2020, appel à projets 2020)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : SIGNED

In the field of the Electronic Integrated circuit design, the analog-mixed-signal (AMS) physical design of all analog blocks and of whole integrated circuits (IC) based on the Analog-on-Top approach still uses a handmade flow. The Electronic Design Automation (EDA) industry has been working since several years in the application of techniques to make better design and verification tools ranging from synthesis to place & route, timing analysis, analog design and circuit simulations. The AMBEATion consortium will utilize a holistic approach which applies these enhanced tools to categories of designs (i.e. Smart Systems) and drives them through “scriptware” and methodologies which will further enhance the productivity of designers in the design automation of these complex low power devices. Essential strategy of the ambitious multidisciplinary program is the Transfer of Knowledge between the partners and the training of a focused team of researchers on the algorithm developments and their application to the industrial state of the art AMS Back End design flow. The main outcomes of this AMBEATion project will be: i) highly increase designers’ productivity in the area of mixed signal designs (primarily AMS Backend) addressing the needs of industrial users, ii) possibly reduce the silicon products costs as a consequence increase the European industry competitiveness, iii) provide the academies with new advanced training topics aligned with high tech employer’s needs, iv) set the basis of a long lasting technical partnership between European research and design centers.

Mots clés : analog, mixed signal, back end design, integrated circuit, design automation, electronic design automation, computer aided design, artificial intelligence, machine learning, data mining

Participants :
- Snps portugal unipessoal lda (Portugal) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Polytechnic University of Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 124200.0 €
- Synopsys netherlands bv (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Catania (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 59800.0 €
- STMicroelectronics (Italy) (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 13800.0 €
- Synopsys armenia cjsc (Arménie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 4600.0 €
- Czech Technical University in Prague (Rép. Tchèque) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 36800.0 €
- STMicroelectronics (Czechia) (Rép. Tchèque) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 18400.0 €
Projet DESTINY (Horizon 2020, appel à projets 2019)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

In the global context of the launched "European Battery Alliance" and "European Technology & Innovation Platform, Batteries Europe", many Universities, Research Centres and supporting organisations have agreed to build the Battery 2030+ consortium as an ambitious European initiative for long-term research on ultra-performant batteries, with a clear focus on addressing obstacles preventing future batteries to reach their true potential. The MSCA COFUND DP project DESTINY will contribute substantially to the launching of this initiative at the education level through its advanced DP training adhering to key research areas of the Battery 2030+ long-term roadmap, including the development of a materials acceleration platform (MAP) and the establishment of the battery interface genome (BIG), combined as BIG-MAP. DESTINY will also contribute to short-to-medium term roadmaps identified by Batteries Europe so as to bring know-how and new emerging technologies for the future, for both industrial and academic professionals. DESTINY is a DP programme coordinated by the French CNRS, that will create a paradigm change in battery research, in line with the new European context. The 5-year project will train 50 PhDs on: 1) Reinvent battery materials discovery and engineering, 2) Develop smart batteries and functionalities 3) Implement new technologies in industry. All of these benefit from the combined excellence of the DESTINY consortium : 40 partners from 12 European countries, including Universities, Research Centres, Large Scale Facilities and 8 Companies. All candidates will be trained at the very forefront of battery research to enable them to accelerate and exploit novel technologies from a solid basis of knowledge and skills. Interdisciplinary competences and skills will be favoured through the complementarity within DESTINY. In addition, DESTINY includes a broad set of trainings in transferable skills: personal effectiveness, research governance and entrepreneurship.

Mots clés : batteries, energy storage, electric vehicles, materials science, electrochemistry, sensors, multiscale modeling, smart functionalities, supercapacitors, reverse engineering, advanced spectroscopies

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 4068000.0 €
Projet QAPs (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

In the human genome, many G-rich sequences have the potential to form 4-stranded non-canonical secondary structures known as G-quadruplexes (G4s). G4 structures have been visualized in nuclei by immunofluorescence and mapped genome-wide to regulatory chromatin regions linked to elevated transcription using G4 chromatin immunoprecipitation and high-throughput sequencing (G4 ChIP-seq). G4s are implicated in gene regulation, DNA replication and genome instability, yet little is known about their protein interaction partners or role in regulating genome activity. We therefore propose to develop G4 Rapid Immunoprecipitation Mass Spectrometry of Endogenous Proteins (G4 RIME) methodologies to elucidate the G4 interactome within a native chromatin context. ChIP-seq of protein candidates coupled with G4 ChIP-seq will verify binding at endogenous G4 structures. Using established biophysical and biochemical techniques, we will investigate binding modes, recruitment and effects on G4 dynamics. Consecutive chromatin immunoprecipitation steps using antibodies targeting characteristic chromatin marks as well as G4 ChIP-seq supported by bioinformatics analysis of genomic databases will identify proteins involved in transcriptional regulation. We will then test the consequence of stabilising G4s with small molecule ligands on the G4 interactome and how this is modulated during genomic stress. Cells genetically deficient in G4-interacting proteins will enable detailed exploration of G4 formation and transcriptional effects. This highly interdisciplinary project will provide a wide range of excellent training opportunities exploiting the Balasubramanian group’s unique position with laboratories at the Cancer Research UK Cambridge Institute (CRUK CI) and the Department of Chemistry. Overall, the studies will generate novel functional insights in the G4 biology that may ultimately lead to the identification of mechanisms and pathways for new anti-cancer agents.

Mots clés : g quadruplexes, chemical biology, proteomics, functional genomics, dna protein interaction, chromatin, transcription, transcriptional regulation, genome stability

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet TLDR (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In the information age, technological developments have drastically increased the amount of texts available through different media. This has led to a shift in reading habits from close reading, sustained and focused attention to the text, to hyperreading, non-linear, computer-assisted modes of reading such as skimming and scanning. Consequently, some fear, young people are losing the ability to concentrate. Many scholars align literary reading with close or deep reading and maintain a strict binary conception of this mode and hyperreading at the opposite pole. TDLR proposes that (a) readers tend to modulate between the two modes, that are more integrated than is often assumed and that (b) this is especially true for literary reading, as literary texts demand of their readers to switch between close and hyperreading. The research project will therefore ask: Does reading literature help to make us better at allocating and modulating attention? What elements in literature prompt readers to pay close attention, and what elements invite a more distracted reading? Are experienced literary readers more skilled at determining when to zoom in and close read, and when to skim? And is this skill transferable to non-literary (information) environments and texts? This study will combine textual analysis with questionnaires, eye-tracking experiments, and interviews to answer these questions.

Mots clés : attention, concentration, close reading, culture, distraction, education, digitalization, hyperreading, literary reading

Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Tilburg University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 253052.16 €
Projet SESED (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In the last couple of years, with the surge of migrants crossing the Mediterranean Sea, migration, and forced migration has been gaining more attention. With a strong focus on desperate individuals, risking their lives on leaky boats, a stereotypical and limited picture is portrayed of migration in Africa and the Middle East. African forced migration has many different trajectories and in order to obtain a full comprehension of what conflict-related migration means and looks like the many different aspects of it need to be explored and understood, by academics and policymakers. Both urban residing and self-settled displaced people have received less attention by academics and policymakers alike. In addition, people of a high socio-economic position who forcibly move due to conflict in their home country, have received little to no attention. This research aims to fill this particular gap by exploring the lived experiences of Burundians of a high socioeconomic status who fled Burundi in 2015 and have been living in Kigali, Rwanda since. The overall objective is to explore what role socio-economic status plays in experiences of displacement, looking specifically at the decision to leave and choice of destination, integration into the host community, connection to the home country, and how gender interlinks to these experiences. The objectives will be reached using semi-structured interviews, supported by participant observation to ask forced migrants from Burundi about their experiences. The project is of importance for the Marie Sklodowska-Curie actions as it contributes to adding and deepening knowledge in relation to Sustainable Development Goal number 16 on peace, justice and strong institutions and to UNHCR’s Global Compact on Refugees. It also gives an opportunity to the researcher to restart her career in a EU country and through secondment to link institutes in an EU country and an AC that have not been linked before.

Mots clés : burundians, rwanda, socioeconomic status, forced migration

Participants :
- Nordic Africa Institute (Suède) — Coordinator, beneficiary, Recherche, subvention : 305778.24 €
Projet SMaRT (Horizon 2020, appel à projets 2016)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

In the last decade, a growing number of railways and other civil or industrial infrastructures have been designed and/or built in arid regions worldwide. The European Railway Industry is often selected for such projects, because of its strong overall know-how. In arid environmental conditions, windblown sand can have undesired effects on both the safety and the serviceability/ maintenance of railways. Despite efficient Sand Mitigation Measures (SMM) are mandatory, their design and assessment are at their infancy worldwide. Both tasks require innovation and development, by means of transfer of knowledge from base and/or specialist research fields to the Civil Engineering design practice and Railway Industry. The European Railway Industry competences should be enriched with advanced and specialized knowhow in the SMM field, by means of raise of the quality of knowledge and human capital. Innovative sand mitigation competences should find their place in the production chain of the Railway Industry. The present Research and Training Programme is inspired by the problem features mentioned above and aims at: • innovating the sand mitigation research field, by: o a Computational Based Engineering rationale approach to the design of SMM; o a new approach to the modeling and simulation of the coupled multiphase wind-sand flow around three-dimensional complex orography SMM and railway body; • training Early Stage Researchers (ESRs), by means of: o a multidisciplinary doctoral formation because of the nature of the problem; o an academy-industry intersectoral doctoral formation because of the innovation ability of the former and the stimuli to research coming from the needs of the latter; o a consortium's layout reflecting the production chain of the railway industry to train the ESRs in a proper “in vitro” replica of the their future real world working context; • enriching and complementing the competences of the European Railway Industry in a growing market sector.

Mots clés : railways, arid environment, sand mitigation, modelling, computational simulation, design, analysis, performance assessment, civil engineering, railway engineering, aeolian geomorphology

Participants :
- Polytechnic University of Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- Reco s.r.l. (Italie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Optiflow (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 262875.6 €
- University of Oxford (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- Astaldi spa (Italie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Ansaldo (Italy) (Italie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €