Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MultiphaseGTR (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Periodontitis is one of the world's most prevalent chronic dental and maxillofacial diseases that will ultimately lead to unwanted tooth loss. This disease was responsible for a significant loss of € 158.64 billion in Europe in 2018. Due to the complexity of the grafting treatment techniques, the efficiency of these procedures is notably affected. A bioactive multiphasic membrane/scaffold with different layers has been advised for this. Until now, few commercial companies using synthetic polymers like polylactic acid (PLA), and woven fibers made up of polyglactin 910 copolymer together with collagen have developed this type of membrane/scaffold. However, different limitations of these materials make their application difficult. MultiphaseGTR focuses on the preparation of bioactive multiphase hydrogel-based biomembrane for periodontal regeneration. The fundamental objectives of the study are: I. Development and characterization of the two components of the biomembrane, i.e., non-mineralized hydrogel and mineralized hydrogel membranes (WP1); II. Preparation of a multiphase hydrogel membrane by combining the two components, i.e., non-mineralized and mineralized hydrogel membranes, and characterization of their physicomechanical properties (WP2); and III. Assessment of the bioactive properties of the multiphase biomembranes in relation to periodontal regeneration (WP3). Finally, a suitable multiphase membrane will be recommended. The outcome of this proposed work not only intends to fill the current gap for the requirement of a suitable cost-effective alternative to the current limited reported materials but also to elaborate the opportunity to increase the knowledge regarding the utilization of biomembrane in dental and maxillofacial tissue regeneration.

Mots clés : guided tissue regeneration, periodontal regeneration, chitosan, cellulose, template mediated mineralization, bioactive scaffold, antimicrobial, hydrogel, biomembrane

Participants :
- Université d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226751.04 €
- Health Research Institute of the Balearic Islands (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet MIMIFLEX (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The importance of the gut microbiome has become evident in shaping the ecology and evolution of organisms. Microbiome has been connected to maintaining body temperature in exposure, which can mediate changes at molecular levels and modulate metabolic pathways related to energy regulation. Mitochondria, the powerhouse of cells, is responsible for energy production but also produces heat. Although crosstalk between the gut microbiome and mitochondria has been documented in biomedical research, to my knowledge, no studies have addressed whether this interaction is also observable in wild animals and what kind of effect it has in energy-demanding situations. Also, existing studies on wild systems rely almost completely on correlative data. I will study the crosstalk between microbiome and mitochondria and its effects on the phenotypic flexibility of cold resistance in Great tits. To my knowledge, this is the first time microbiome-mitochondria interactions are studied in wild birds. By experimentally manipulating the microbiome and mitochondrial function in wild Great tits I’ll be able to study the causal effects of the experiments on the cold resistance phenotypes of the birds. Thus, MIMIFLEX will integrate cellular-level mechanisms with the physiology and phenotype of the animal. Dr. Ruuskanen’s research group has profound experience in both, studying microbiome and mitochondria which complements my expertise in physiological ecology, allowing me to develop new research skills and opening a two-way knowledge transfer. Throughout the project, I will gain experience in conducting excellent research, but also in transferable skills such as project management, leadership, acquiring funding and communicating the results. Therefore, this fellowship would help me to solidify my skillset to establish independence as a researcher, open up potential future collaboration and establish a new branch of research on microbiome-mitochondria crosstalk in ecology.

Mots clés : avian microbiome, mitochondria, ecological adaptation, metabolism, fat absorption, environmental variation, gut microbiome, cellular respiration, summit meatbolism, cold exposure, cold acclimation

Participants :
- Université de Jyväskylä (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226276.8 €
Projet MIDAS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The scope of this Marie Sklodowska-Curie Action is contributing to achieve a priority goal for the European Commission: the development of resilient materials for Space technology, thus enabling it to achieve a leading position for the European aerospace industry. In February 2022, the EU Parliament flagged that Europe was critically lagging behind in space technology and market up-take competition. Nowadays, the EU is facing the consequences of geopolitical dependencies in energy, semiconductors and access to space. Space environment is harsh and pushes devices to the limits of radiation tolerance, temperature swifts and mechanical loads. Moreover, electronic devices in payloads and platforms must be lightweight and low volume. In addition, they shall not “interfere” with other sensitive electronic equipment by their own electromagnetic emissions. Three dimensional (3D) magnetic networks have the potential for a highly performance, long-life, and lightweight solution. However, precise fabrication of 3D magnetic metamaterials is expensive and hardly scalable. To overcome these challenges, we propose to use magnetic 3D Nanowire Networks fabricated by electrodeposition in self-assembled 3D alumina templates. The MIDAS project (MagnetIc 3D nAnowire networkS) envisages the capacity to decrease and even suppress the ElectroMagnetic Interference (EMI) and to improve the Electromagnetic Compatibility of space electronics, by developing space robust absorbing 3D metamaterials, able to be conformal to Aluminum chassis simplifying their practical implementation and integration within the structures. To achieve so, Dr. L. G. Vivas will receive hands-on training in complementary experimental techniques at the host group of Prof. M. Martin-Gonzalez at the Institute of Micro and Nanotechnology and the secondment group of Dr. R. Sanz at the National Institute of Aerospace Technique.

Mots clés : aerospace magnetism, micro magnetism, 3d magnetism, electrodeposition, self assembled structures, electromagnetic compatibility

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
- National Institute for Aerospace Technology (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet IMPACT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Blunt force trauma (BFT) is one of the most common type of trauma observed in archaeological studies and forensic cases. Often originating from assaults or accidental falls, determining the exact cause is difficult. Accidents are often associated with multiple traumata occurring in different areas of the body, whereas violent acts show directional trauma patterns. The study of skeletal trauma significantly hampered by insufficient methods to differentiate accidents from assaults. The research will take place under supervision of Prof. Jankauskas, a very experienced forensic anthropologist and bioarchaeologist, at the faculty of medicine at Vilnius University (LT). Based on 500 recent trauma cases from the US, this project will establish new protocols for the analysis of BFT. Trauma frequencies all over the body and features of traumata will be evaluated to identify discrimination factors for the distinction between accidents and assaults. In the second stage, the developed methods will be applied to archaeological samples presenting high frequencies of BFT which will provide new insights into, assaults, accidents, and child abuse in prehistory and will allow to interpret societal changes in the past related to climate change, frailty and famines. Training opportunities and a two-way-knowledge transfer of hands-on forensic case work, trauma & palaeopathological analyses will bring urgently needed know-how to Austria and will provide networking opportunities for new methods for VU, e.g. peptide analyses. This is the first study which analyzes BFT patterns on a large scale to develop new methods for the interpretation of trauma in the past. A systematic evaluation of osteological traumata on a large recent sample has rarely been performed in anthropological studies which makes an interpretation of traumata in cases with unknown contextual data (e.g. in bioarcheological samples) difficult.

Mots clés : blunt force trauma, accidents, interpersonal violence, conflicts, trauma patterns

Participants :
- Université de Vilnius (Lituanie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181136.16 €
Projet GEM-SEE-Achro (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Achromobacter species are rapidly emerging Gram-negative opportunistic bacteria intrinsically resistant to several antibiotics and are often the cause of healthcare-associated infections, especially in individuals with compromised immune systems or underlying conditions. Following years of misclassification of Achromobacter spp. isolates combined with complicated species typing, the understanding of the ecology of Achromobacter spp. and their clinical significance is lacking. GEM-SEE-Achro aims to answer the questions regarding the population structure, evolution, adaptation, antibiotic resistance development, and genetic variability of Achromobacter spp. both globally and locally, providing crucial insights into the factors contributing to their prevalence, antimicrobial resistance patterns and potential novel therapy approaches. Analysis of whole genome sequencing (WGS) data allows to disentangle these questions. Therefore, I propose the largest Achromobacter spp. study to date including over 800 WGS encompassing its global diversity sampled from both the environment and infected patients. Employment of a number of bioinformatics analysis methods—gene content difference analysis; single nucleotide variant and mobile genomic element identification and association with population structure; evolutionary and migration rates analysis using Bayesian phylogenetics; and resistance phenotype association with genomic differences—will help to answer the fundamental questions of how these bacteria evolve and adapt to their environment, what are the main differences in genetic composition between the environmental and clinical samples, and how these differences can inform us about the population structure and antibiotic resistance development in Achromobacter spp. The gained knowledge could be generalised and applied to studies of other less studied bacterial pathogens.

Mots clés : bacteria, evolution, adaptation, genomics, whole genome sequencing, antibiotic resistance, emerging pathogens, cystic fibrosis, opportunistic bacteria, computational biology, health care research

Participants :
- Université de Vilnius (Lituanie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 158597.76 €
Projet BasInCult (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In early modern period, the long-lived rift between Catholicism and Orthodoxy was overbridged by the Union of Brest (1596): it established the Uniate Church in the region reaching from Lithuania through Poland and Belarus to Ukraine, and it was the basis for the development of local monastic structures, the Basilians. While the research on Uniate and Basilian literacy, significantly underrepresented in an international discourse on post-Tridentine Christianity and its culture, is interested mostly in Basilian book and printing history, BasInCult pursues for the first time a detailed and qualitative analysis of the writings about the saints and candidates to sanctity (hagiography), who had a programmatic and symbolic meaning, in a wide spectrum of literary forms created and circulated in the 17th and 18th centuries. It is argued that the Uniates and Basilians used hagiographic sources not only to adapt Uniate Church to the framework of the Catholic culture, but especially to include their issues in the mainstream of Catholic discourse. Focusing on the instructive examples of saint figures (e.g. Josaphat Kuntsevych), works (e.g. "Menologium bazyliańskie"), and hagiographers who served also as Order’s officials (Ignacy Kulczyński), the project demonstrates the strategies of such a mutual adaption process (regarded as inculturation) which had a vast impact on shaping the confessional and cultural landscape of today’s central-eastern Europe. The project will be affiliated at Vilnius University, in an exceptional environment of the specialists in Uniate history and Basilian monasticism; in addition, it will be carried out close to the text sources held in a great part in Vilnius, one of the main centres of Basilian activities. The results will be published in an article and a short book monograph which will both aim at popularising the project’s topic and themes.

Mots clés : neo latin literature, early modern hagiography, early modern cult of saints, basilian order, kuntsevych, early modern church history, vilnius

Participants :
- Université de Vilnius (Lituanie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 142757.76 €
Projet HeNaId (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

What role did textual exchanges (epistles, journal essays and newspaper articles) between Italian philhellenes and (Italian)-Greek intellectuals refugeed in Italy (due to long-term cultural/political bonds) and Switzerland (as host country for many Greek exiles) play in setting ground for the 1821 Greek Revolution? How did the reflections of these intellectuals on the idea of Greekness, on contemporary historical events and on the illuministic ideas contributed to the process of national identity negotiation underlying the Revolution? Answering these questions is crucial to fully understand the role of the Greek Revolution in shaping modern Europe. HeNaId will offer the first in-depth study of these textual exchanges, focusing on texts by major (Italian-)Greek intellectuals with a focus on the poet Ugo Foscolo as a leading figure among those. While the ideological roots of Greek Revolution are generally studied from historical-philosophical or iconographic perspectives, HeNaId will fill a gap in scholarship by adopting an interdisciplinary approach combining archival and bibliographical research with a philological-literary investigation to 1) map out the political and cultural networks of (Italian)-Greek intellectuals between 18C and 19C across Greece, Italy and Switzerland; 2) study the texts exchanged within these networks to understand their degree of influence; 3) highlight the so-far neglected role played by Foscolo in promoting and orientating these cultural networks. Employed methodologies will be greatly improved through an outgoing phase at the leading Foscolo study group of the University of Fribourg, a secondment at the Laboratory in Italian History and Historiography at the Kapodistrian University of Athens and thanks to the main host University of Bergamo’s commitment to textual criticism. Working at these institutions will deepen my skills in Italian/Neo-Hellenic studies, thus accelerating my career goal of obtaining a tenure at an EU University.

Mots clés : cultural networks textual exchanges ugo foscolo philhellenism greek revolution italian literature neo hellenic literature

Participants :
- Université de Bergame (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 412700.52 €
- Université de Fribourg (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université nationale et capodistrienne d'Athènes (Grèce) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet NeuProHRI (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Nowadays, cerebrovascular diseases are devastating conditions representing a large cause of mortality worldwide. It is estimated that 1.1 million people suffer a stroke every year in Europe. Due to the lack of a reliable treatment for stroke, it is important to keep looking for new treatments that stop the progression of the insult by providing neuroprotection, and even promote neuronal recovery for those neurons already affected by the condition. The goal of NeuProHRI is to study the potential of targeting the HRI kinase cellular cascade as a new therapeutic aim for stroke. To develop this, I will use a combination of cutting-edge molecular techniques to define the cellular pathways underlying the activation of the HRI kinase, and their effect on promoting neuroprotection in in vitro and in vivo models of stroke. First, I will decipher the molecular cascade following the activation of HRI in primary cultured neurons by pharmacological and genetic approaches. Then, in vitro models of stroke will be used to measure the impact of these treatments in cells with stroke-like phenotype. Finally, mouse models of stroke will allow me to tackle the impact of pharmaceutical and genetic treatments on in vivo brain tissue. Moreover, Ribo-seq analysis will be performed to study accurately protein synthesis and its relation to neuron-intrinsic pathways involved in stroke. There is a clear benefit of the mobility for both the applicant and the host, ensuring high quality results and dissemination. In this regard, the host will ensure the acquisition of new technical, management, tutorial and transferable skills. The applicant will also benefit from a multidisciplinary environment enhancing international collaboration that will surely contribute to diversify his career. Finally, via a specialized Career Development Plan, the host will provide the ideal training and validation environment, through which the applicant will reach unprecedented levels of professional maturity.

Mots clés : stroke, er stress, eif2a, hri, btdcpu, neuroprotection, ribo seq

Participants :
- Institut national de la santé et de la recherche médicale (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Instituto de Investigación Sanitaria de Santiago (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet MARPERWISE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Submarine permafrost, a vital component of the Arctic environment, plays a significant role in geological and environmental processes. However, critical knowledge gaps persist, necessitating comprehensive investigations. Our project, 'MANPERWISE,' seeks to address these gaps and enhance our understanding of this dynamic phenomenon. Despite advancements, uncertainties surround the extent, thickness, and degradation of submarine permafrost in the Arctic. 'MANPERWISE' aims to quantify these aspects within a designated study area, employing a state-of-the-art controlled-source electromagnetic (CSEM) system developed by the University of Malta. One key objective is to unravel the intricate relationship between permafrost degradation and seafloor geomorphic changes, with a specific focus on seafloor instability. By analysing data acquired through our CSEM system and comparing it with seafloor morphology, we aim to elucidate the mechanisms driving these transformations. Furthermore, 'MANPERWISE' envisions the development of a conceptual design for a Remotely Operated Vehicle (ROV)-based or Autonomous Underwater Vehicles (AUVs)-based CSEM instrument. This advanced tool will enable high-resolution, repeat mapping of submarine permafrost and Submarine Groundwater Discharge (SGD). Such innovation promises transformative insights into the Arctic's evolving dynamics. Dissemination efforts encompass scientific publications, research conferences, seminars, a dedicated project website, and engagement with policy-makers and the general public. Guided by Prof. Charles K. Paull (MBARI), Prof. Aaron Micallef (University of Malta), and Prof. Mark Everett (Texas A&M University), ‘MANPERWISE’ addresses critical knowledge gaps in submarine permafrost dynamics, offering insights with implications that extend beyond the Arctic region to global climate processes.

Mots clés : marine science, seafloor exploration, permafrost dynamics, climate change mechanisms, geophysical surveys, csem technology, hydrogeological processes, arctic environment, subseafloor mapping

Participants :
- Université de Malte (Malte) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 259429.92 €
- Monterey Bay Aquarium Research Institute (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
- Energy and water agency (Malte) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €