Projet MetRaZymes (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : SIGNED

The pharmaceutical, chemical and polymer industries are cornerstones of Europe’s economy. A key element for their transition to more sustainable processes and to innovative new compounds is biocatalysis. Of particular interest are metallo-enzymes, i.e. proteins that host a metal cofactor. They catalyze a multitude of redox and radical reactions. To access reactions that are unknown in nature, artificial metallo-enzymes can be created. They combine the new-to-nature catalytic activity of metal complexes with the selectivity-inducing environment of the active protein site. To develop novel biocatalysts, a highly interdisciplinary skill set is needed. MetRaZymes will create a PhD school across leading European universities that will train the next generation of scientists capable of tackling the design, development and implementation of novel enzymatic reactions in a holistic approach. It brings together computational bioscientists, bioinorganic and polymer chemists, and bioprocess engineers. Using artificial and repurposed metalloenzymes as the focal point, the ESRs will develop novel biocatalysts for radical reactions of high synthetic value, such as the late stage modification of pharmaceutical intermediates or the synthesis of polymers from renewable monomers. To train the ESRs in the needs of industrial biotechnology, the consortium includes eight of Europe´s leading pharmaceutical, chemical and enzymology companies. The ESRs will benefit from a vast transferable skills training program delivered by five training partners. Highlights include a Nature Masterclass and Wikipedia workshop. Communication partners such as Wikimedia and the Industrial Biotechnology Innovation Centre will act as muliplicators for the communication of results. Moreover, the ESRs will work with artist that use biology as their way of expression to create an ARTzymes exhibition that will foster the ERS´s creativity and result in a an unique form of science dialogue with the general public.

Mots clés : artificial metalloenzymes, non native biotransformations, radical chemistry, radical polymerizations, directed evolution, protein engineering, computational biochemistry, bioprocess engineering

Participants :
- BASF (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Biofaction (Austria) (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Corning sas (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Milan (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 259437.6 €
- Universität für Bodenkultur. Vienne (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 360441.6 €
- Université de Berne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Inseit ag (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de technologie de Darmstadt (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 434232.0 €
- Université de Strathclyde (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Dortmund (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 260539.2 €
- Thales (Germany) (Allemagne) — Partner, associated partner, Autres, subvention : 0.0 €
- Novalyst Discovery (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Brain (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Forschungszentrum Jülich (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Wikimedia CH (Suisse) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université de Bâle (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Novartis (Switzerland) (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Stuttgart (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 260539.2 €
- Novozymes (Denmark) (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Manchester (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Springer Nature (Netherlands) (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- École polytechnique fédérale de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Groningue (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 548740.8 €
- Université de Strasbourg (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 282693.6 €