Projet DarChemDN (Horizon Europe, appel à projets 2022)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : SIGNED

Darwinian evolution is unrivalled in its ability to invent, which Humankind has already exploited for various purposes such as plant and animal breeding and directed evolution of proteins. In these examples, evolution acts on living species or material derived from them, but so far it has not been possible to apply Darwinian evolution outside the realm of biological and some computational systems. The aim of the DarChemDN research programme is to develop Darwinian Chemistry by creating, for the first time, synthetic chemical systems that can reproduce and undergo open-ended Darwinian evolution.  Our pioneering concept will be implemented in a joint effort by 10 doctoral candidates (DCs) working on (1) the identification and development of viable autocatalytic systems, (2) incorporating these systems into compartments (emulsions and coacervates) to couple autocatalysis to compartment growth and division and (3) integrating metabolism in the new systems, to (4) enhance evolvability and achieve Darwinian evolution.  We have assembled a consortium of scientific excellence that brings together multiple ERC grant holders, supervisors of several previous MSCA-ITNs and highly innovative companies with complementary expertise to deliver this unique research and training programme. Exploiting the full potential of the envisioned scientific breakthroughs requires a structured training programme to equip the first generation of Darwinian Chemists with advanced scientific, business, and transferable skills. In the long-term, we envision that the DarChemDN DCs will unleash the power of Darwinian evolution to have a profound impact on applied chemistry and materials science in areas ranging from catalysis to sensing and signalling by allowing optimisation of functions through evolution.

Mots clés : systems chemistry, darwinian evolution, autocatalysis, self replication, coacervates, droplet microfluidics, reaction networks

Participants :
- Microfluidics innovation center (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 282693.6 €
- Université de Trente (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Accelopment (Switzerland) (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- École supérieure de physique et de chimie industrielles de la ville de Paris (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 565387.2 €
- Dewpoint therapeutics gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Parmenides Foundation (Allemagne) — Partner, beneficiary, Recherche, subvention : 260539.2 €
- Paradigmatic-innovations gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Ben Gourion du Néguev (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 542865.6 €
- Université de la Sarre (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 521078.4 €
- Spectrometry vision bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Louis-et-Maximilien de Munich (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Groningue (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 548740.8 €