Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Cross-Bit (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Formation of C‒C bonds through transition metal-catalyzed cross-coupling represents the cornerstone strategy to build chemical complexity in a myriad of contexts, spanning from academic laboratories to industrial settings. These remarkable reactions generally proceed through three elementary steps —oxidative addition, transmetallation and reductive elimination— which couple two organic fragments together using transition-metal complexes as redox-active catalysts. Very recently, bismuth —a main-group element— has been found to take part in this type of redox events, resulting in the formation of different C–heteroatom bonds, or in H-transfer processes. However, the use of bismuth redox catalysis to forge the highly coveted and synthetically relevant C–C bond remains elusive.  In this project, we aim to harness this novel redox behavior of bismuth complexes to unlock the unprecedented bismuth-catalyzed C–C cross-coupling full catalytic cycle between organic electrophiles and organometallic nucleophiles. For this, we propose the design of a low-valent bismuth(I/III) redox platform, which would cycle through the three key steps of a classical transition metal-mediated coupling. This will involve the study and optimization of challenging processes (such as an unprecedented C–C reductive elimination at a bismuth(III) center), which will be approached through a combination of careful ligand design, experimental/theoretical mechanistic analysis, and combinatorial screenings.  Besides the conceptual breakthrough derived from such discovery, this idea will be used to implement bismuth-catalyzed cross-coupling reactions as competent, cheaper, and less toxic alternatives to traditional methods based on transition-metal catalysis. Furthermore, the unique properties of bismuth as a main-group redox catalyst could potentially combine advantages of both early and late transition metals, resulting in the development of more versatile catalytic systems.

Mots clés : main group metal catalysis, bismuth catalysis, cross coupling reactions, synthetic methodology development

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet UrbanCommunityAtWar (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Civil society is often seen as a key driver of democratization, helping to open up authoritarian regimes and pave the way for political transitions. Despite these perceptions, research indicates that practices of political engagement in authoritarian regimes is often overlooked or misunderstood. In Russia, grassroots political activism has a long history, even if it remains fragmented and localized. Citizens often organize at the community level to address immediate social and economic concerns, particularly in times of crisis. This form of participation, though not always recognized as political, demonstrates the persistence of civic engagement even under repressive conditions.  During periods of profound upheaval, such as World War I and the Russian Revolution, ordinary people began to establish informal networks and self-governing bodies, like housing committees and cooperatives, to meet their needs and protect their interests. These grassroots efforts contributed to the development of democratic practices, even in the absence of formal democratic institutions.  This project seeks to explore the spread of self-governance and civic engagement in Russian cities between 1914 and 1922. It focuses on how different social groups, often with no prior experience in political participation, became involved in addressing the challenges posed by war and revolution. By examining local forms of self-organization and communication, the study will shed light on the role of ordinary people in shaping their communities and influencing political processes. Understanding these dynamics will provide new insights into the history of Russian society and the broader role of grassroots activism in political change.

Mots clés : democratic practices, russian revolution of 1917, urban society, housing committees

Participants :
- Université de Nottingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet DyThM-FCC (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The core aim of DyThM-FCC is to push the envelope of additive micro-manufacturing (AµM) and micromechanical testing under extreme conditions and identify a constitutive strengthening law by using machine learning (ML). A novel printing method, based on localized electrodeposition in a voxel-by-voxel manner, will be used to print metallic microparticles of Ni, Cu and Co. Subsequently, these microparticles will be subjected to thermal treatments to control the internal microstructure, i.e. change the dislocation content and grain size. These metallic microparticles will be tested under a combination of unprecedented strain rates (SR) up to 1000/s and temperatures from -150°C up to 600°C for assessing their suitability and reliability in extreme applications (e.g. sensors, where are subjected to high frequencies, or catalysis, where high temperatures can be expected). Depending on the applied SR and temperature several deformation mechanisms can contribute towards the deformation of face centered cubic (FCC) microcrystals as a function of the stacking fault energy (SFE). Ni, Cu and Co has been selected for this study as their SFE is very different, i.e. 128, 75 and 15 mJ/m2, respectivley. As such, a complete deformation map of pristine microscale pure FCC metals will be obtained as a function of temperature, SR, SFE and defect density, based on the stress-strain signatures, extracted thermal activation parameters such as activation volume/energy and microstructural characterization from scanning and transmission electron microscopy (SEM/TEM). Finally, all that information will be used to feed a ML strategy in which the parameters of a constitutive law will be extracted. DyThM-FCC will test the limits of cutting-edge technology in EU research arena by exceptional cooperation between complementing scientific fields.

Mots clés : in situ micromechanics high strain rate cryo and high temperature additive micromanufacturing machine learning

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet SOUNDSHIP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The maritime route between Venice and Jerusalem testified to an incredible exchange of thousands of people in the fifteenth and sixteenth centuries. Among these were pilgrimages, which gathered transregional, multiethnic and multireligious communities, brought together through sound in spite of their language, cultural and religious differences. Pilgrims’ diaries narrate a sense of community that was initiated and preserved by sound phenomena such as noise and silence, sonic practices such as sounding trumpets or whistles, and various music practices, including chanting. In the current time, marked by intensifying interethnic, intercultural and religious tensions, my project advocates for and fosters multicultural cohesion within modern society.  Despite being naturally prominent in general early modern travel, sound’s meaning for the travelling community remains under-researched, and has rarely been considered within in-between, transitional spaces of mobility and cultural exchange. SOUNDSHIP offers a new, far more more nuanced understanding of sound perception in early modern communities, their formation and preservation, and will be the first systematic study of sound and music in early modern travel. It will do so through an innovative application of sound studies, auditory history, historical musicology, religious studies, and performance practice research on pilgrims’ narratives, philosophical, music, medical treatises, and music practices.  With a strong track record in assessing music historiographies through sound studies, Dr Cugelj will work with Prof James Mansell, an international expert for sound methodology and innovative practices in sound research at the University of Nottingham. The MSCA will establish Dr Cugelj as an independent sound scholar with international reach, advancing the field of historical sound studies through the investigation of sonic identities.

Mots clés : sound studies, auditory history, early modern history, transnational history of music, semiology of sound, temporal communities, pilgrimage studies, historical performance practice

Participants :
- Université de Nottingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet BattMaxLife (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Lithium-ion (Li-ion) batteries have an integrated battery management system (BMS) whose performance is critical in maximizing the available life of the batteries and increasing their sustainability. The BMS monitors state parameters, such as state-of-charge (SOC) and state-of-health (SOH), for safety and performance optimization purposes. The accuracy of these parameters plays a critical role in maximizing the available battery lifetime. This MSCA fellowship project aims to maximize the available lifetime of Li-ion batteries (and subsequently the lifetime of their applications) by making the battery impedance accessible in real-time for the BMS state estimation algorithms by using a novel ternary-sequence impedance measurement method that is integrated onboard the battery pack. The impedance-based SOC and SOH estimation algorithms will offer higher accuracy compared to the available traditional algorithms. Thus, the BMS will be able to optimize the battery's use and consequently maximize its life in its primary application (i.e., first-life application), such as in electric vehicles. Despite lacking the performance for the primary application, the battery is still likely to be used in a less demanding application, i.e., stationary energy storage. With adequate health information available (using the novel impedance-based algorithms) at the end of its first-life, the battery will become an attractive candidate for second-life application, as reliable predictions can be made about its remaining lifetime, safety, and economic value. With first-life maximized and second life provided for the battery pack, the lifetime of the battery is significantly prolonged before the eventual recycling, increasing Li-ion batteries' sustainability This highly innovative project has a high scientific, economic, and societal impact. Furthermore, the project will allow the applicant to enrich his technical and managerial skills thus boosting his career prospects and enlarging his horizon

Mots clés : batteries, impedance, state of health estimation, state of charge estimation, battery management systems

Participants :
- Université d'Aalborg (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet SOVILASAZION (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

SOVILASAZION is an interdisciplinary historical project dedicated to studying Soviet anti-Zionism as an element of Soviet foreign policy’s ideology. Using previously unavailable recently declassified archival sources, the project will be set out to analyze the interconnections of Soviet anti-Zionism with the practices of Soviet foreign policymaking in the circumstances of the Global Cold War and will discuss them in relation to the domestic antisemitic discriminatory practices in the USSR. By doing so, SOVILASAZION will broaden our understanding of the ideological legacy left from the Cold War era for our times, when the discussion about the difference between antisemitism and the permitted criticism of Zionism is even hotter than 40-60 years ago. Addressing Soviet anti-Zionism as an element of Soviet foreign policy’s ideology, SOVILASAZION will investigate the history of the post-1967 relations between the USSR and Israel. It will address the attempts of the more pragmatically oriented wing of Soviet bureaucracy to lobby the restoration of the official diplomatic relations that had been broken off after the 1967 Six-Day War and study how the ideological limitations prevented such restoration. SOVILASAZION will also address the functioning of the Soviet bureaucracy in the sphere of foreign policy, it will highlight the heterogeneity of Soviet bureaucratic apparatus and, overall, will broaden our understanding of this underresearched part of the Cold War history.

Mots clés : soviet union ideology cold war antisemitism anti zionism israel foreign policy

Participants :
- Université de Cardiff (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet RIDERS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Roman society is elitist by nature and is thus represented by most available sources. Roman imperial elites have been long investigated, however scholars usually focused only on the two extremes of elites, either the top level (elites employed in high imperial administration), or the bottom one (civic elites). No attention was devoted to investigating the existence of a “middle-elite”. The RIDERS project offers an innovative investigation of Roman imperial elites with the ambitious purpose of changing traditional models of interpretation, moving beyond a top-down approach (i.e. focusing on the top level) and a bottom-up one (i.e. focusing on the bottom level), by developing a ground-breaking middle-out approach. After over three decades since the last complete work devoted to equestrian officers, the RIDERS project re-addresses the entire corpus of the 2,500 equestrian officers currently known, to develop an innovative tool for an in-depth investigation of imperial middle-elites. By applying a multidisciplinary methodology, based on traditional prosopography integrated with sociological methods and supported by digital humanities, the RIDERS project will develop, as its main outcomes, the first database devoted to equestrian officers and the first monograph on imperial middle-elites. The ambition of the RIDERS project consists in applying also to elites the social concept of “middle”, usually employed only for the remaining part of society. Suggesting that even elites had a “middle”, not only a top or a bottom, will ambitiously contribute to improving our knowledge of Roman society, which was much more complex and variegated than studies have hitherto highlighted.

Mots clés : equestrian officers ordo equester roman imperial elites roman imperial administration roman imperial society

Participants :
- Université Bordeaux Montaigne (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet MetaboSplicing (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Neurodevelopmental disorders (NDDs) affect 3-8 percent of children across Europe and cause a life-long alteration of cognitive abilities or social interactions with little therapeutic possibilities. Recent studies have uncovered that dysfunctional mitochondria and metabolism are involved in NDDs like intellectual disability and autism spectrum disorder. Notably, neuronal circuit development, a crucial process during the formation of the brain, is characterized by an increase in metabolic activity supporting a period of intense remodelling. However, the knowledge of molecular processes controlling metabolic homeostasis during neural circuit development is still incomplete. We recently defined the autism-associated kinase NUAK1 as a critical regulator of local mitochondrial metabolism in neurons, supporting axon morphogenesis. However it is not clear how NUAK1 controls metabolic processes in neurons. We have identified a novel substrate of NUAK1 and hypothesize that NUAK1 controls an alternative splicing program through this new interactor, thereby regulating metabolism, which in turn affects neuronal development. We will: 1. Perform a phenotypical characterization of the novel substrate’s role in developing neurons in vitro and in vivo; 2. Investigate its effect on neuronal and axonal metabolism; 3. Characterize its associated transcriptomic signature in developing neurons; and 4. Assess the role of NUAK1 in controlling its novel substrate functionally. For this, we will use state-of-the-art techniques like microfluidic devices and deep-sequencing of mRNA. This ambitious project aspires to describe a new cellular pathway, integrating RNA biology and metabolism in developing neurons and will provide the first characterization of a novel interactor of NUAK1 and its control by the latter in developing neurons.


Participants :
- Lyon-I université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet 3D-MEMorpho (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

How the organismal morphology is specified, maintained, and evolving is an intriguing open question of developmental biology and biophysics. In this proposal, I aim to unravel the physical mechanisms underlying the three-dimensional (3D) morphodynamics of epithelium. Drosophila wing disc is a good model organism for this problem because it undergoes complex 3D morphogenetic processes from larval to pupal stage which are highly related to gene expression, hormone level, cell active behaviors, and mechanical forces. The correct sequential folding, unfolding, and eversion of wing disc have been observed as exquisite and elaborated processes while the underlying physical mechanism is still unclear. We will establish a biomechanical theoretical framework with a novel hybrid vertex-continuum model, and develop advanced numerical simulation methods to mimic wing disc three-dimensional morphodynamics. A morphometric analysis method and statistical quantifications will be developed and applied, for the first time, to quantitatively compare the simulation and experiments performed by my collaborators.

Mots clés : three dimensional morphogenesis biomechanical modeling cell ecm interaction ecm remodeling

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 202125.12 €
Projet RecAminoAge (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Plants constantly face environmental challenges, impacting ecosystem stability, promoting new pathogens and compromising food security. A fundamental question in evolutionary biology is whether repeated adaptations, driven by similar environmental pressures, rely on the same genetic programs, especially over long timescales. Protein sequences, increasingly available across diverse lineages, offer a unique opportunity to tackle this issue on an unprecedented scale. However, as evolutionary divergence increases, current methods result in substantial information loss and an inherent bias due to reliance on a single optimal alignment configuration. This, in turn, makes it difficult to identify which substitutions among billions could convergently alter adaptive phenotypes.  To overcome these challenges, I will establish a novel framework for inferring common evolutionary origins by incorporating suboptimal alignment configurations. Summarized as “amino acid ages”, I will date protein substitutions in a ladder-like fashion until a substitution is no longer stable in the suboptimal alignment space. The taxonomic level of the detected substitution will indicate the evolutionary origin/age of an amino acid within a protein. I hypothesize that amino acid ages capture emerging nuances missed in divergent lineages since suboptimal configurations may expose hidden evolutionary constraints.  First, I will develop a fast and scalable computation of amino acid ages for community use. Second, I will generate a resource containing amino acid age annotations for all available plants. Third, I will establish associations between candidate protein substitutions that lack assigned ages, not acquired through common ancestry, and recurrent adaptive traits.  RecAminoAge will provide the community with a disruptive methodology that sheds light on protein evolution rates over long timescales while enhancing predictions of species retaining valuable adaptations to tackle future challenges.

Mots clés : protein evolution, optimal alignment bias, amino acid ages, database, parallel evolution

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 202125.12 €
Projet VICONS-EMMA (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Women's presence in warfare and armies was commonplace in early modern Europe. Whether within armies, in transit areas, military lodgings, permanent military residences, or in besieged cities, it is possible to find their traces. Yet while there are numerous studies of these women’s lives and experiences in central and northern Europe, research for southern European regions remains scarce. This project therefore aims to study the roles and experiences of non-elite women who lived in or came into close contact with armies in sixteenth-century Italy by examining practices, discourses and representations of sexuality and violence. Due to the protracted wars and occupations that unfolded in the Italian Peninsula during the 16th century, the region provides an ideal setting for this research. In particular, VICONS-EMMA will focus on the presence of Spanish soldiers as they provide a crucial perspective for understanding the social impact of both short and long-term military occupations, particularly considering that many Italian states eventually hosted permanent Spanish garrisons. The project employs a mixed methodology, integrating qualitative analysis of legal and theoretical military texts, visual sources and, most importantly, archival records to uncover the voices of these women. This approach will deepen the understanding of sexuality and violence in the complex era of the Reformation/Counter Reformation and open up new debates between Gender and Military History. The project features a major outreach strategy that seeks not only to raise awareness of the importance of women's role in early modern warfare, but also to encourage debate about sexual violence in contemporary military contexts. It will enable the Experienced Researcher (ER) to expand her methodological tools and skills for consolidating a permanent academic position and significantly improve the ER's employability in non-academic job markets such as Public History and historical consultancy.

Mots clés : women in war, women in armies, early modern italy, sexuality, military violence, war experiences, sexual violence, gender based violence

Participants :
- Université métropolitaine de Manchester (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €