Projet MITGEST (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : SIGNED

Mitochondria produce most of the energy the body acquires through food, and are thus pivotal players in cellular metabolism. Central to mitochondrial biology is the DNA in the organelle (mtDNA): its maintenance, correct RNA processing, and efficient translation are all essential and must be coordinated to ensure proper mitochondrial function and cellular physiology. Defective maintenance or expression of mtDNA alters energy and nutrient metabolism, which are increasingly recognized to impact medical disciplines, ranging from hundreds of genetic disorders to neurodegeneration, immunology, transmissible disease, cancer and ageing. A deep understanding of the mitochondrial gene expression system and new methods are urgently needed to develop treatments for the full panoply of mitochondrial disorders that feature mtDNA perturbation. MITGEST will unite world-class academic excellence in mtDNA maintenance and expression with private sector expertise in nucleic acid chemistry and the development of mitochondrial therapeutics to address this urgent need. As the first research training programme in this field to take a fully integrated approach, our 10 doctoral candidates (DC) will elucidate how mtDNA is maintained and expressed and support the development of new methods to analyse RNA and DNA metabolism in mitochondria. These advances will complement and facilitate/enhance innovative treatment strategies and experimental medicine studies designed to mitigate mitochondrial dysfunction in a range of human diseases. Our network of 7 beneficiaries and 12 associated partners from 8 European countries and Israel builds on proven collaborations and establishes new partnerships to deliver intersectoral and multidisciplinary scientific and transferable skills training to our 11 PhD students to generate the next generation of highly-skilled scientists able to exploit the latest advances in mitochondrial biology and medicine.

Mots clés : mitochondria mtdna and mtrna metabolism mitochondrial translation energy and nutrient metabolism diseases mechanisms and models small molecule and nutriceutical therapies for mtdna disorders

Participants :
- Mitocon - insieme per lo studio e la cura delle malattie mitocondriali - odv (Italie) — Partner, associated partner, Autres, subvention : 0.0 €
- Institute of Bioorganic Chemistry, Polish Academy of Sciences (Pologne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Biogipuzkoa Health Research Institute (Espagne) — Partner, beneficiary, Recherche, subvention : 503942.4 €
- Technion - Institut de technologie d'Israël (Israël) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Radboud de Nimègue (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Agilent Technologies (Italy) (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institute of Biochemistry and Biophysics, Polish Academy of Sciences (Pologne) — Partner, beneficiary, Recherche, subvention : 226512.0 €
- Université de Pavie (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut Karolinska (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 293709.6 €
- Radboud University Medical Centre (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 548740.8 €
- Université d'Udine (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Miedzynarodowy instytut mechanizmow i maszyn molekularnych polskiej akademii nauk (Pologne) — Coordinator, beneficiary, Recherche, subvention : 453024.0 €
- 4basebio sl (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université Johann Wolfgang Goethe de Francfort-sur-le-Main (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Careers research and advisory centre (crac) limited (the) (Royaume-Uni) — Partner, associated partner, Autres, subvention : 0.0 €
- Lumicks bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Baseclick gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €
- Minovia therapeutics (Israël) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University College de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Technion - Institut de technologie d'Israël (Israël) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 271432.8 €
- The lily foundation (Royaume-Uni) — Partner, associated partner, Autres, subvention : 0.0 €
- Université du Pays basque (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Accelopment (Switzerland) (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Predica diagnostics bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €