Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet BTBnano (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

BTBnano will use state of the art knowledge and techniques to quantify single-walled carbon nanotubes (SWCNTs) and gold ENMs in cells and tissues. The objectives are to: (1) systematically quantify bioaccumulation and biodistribution of SWCNTs (as a function of size) and Au ENMs (as a function of size, shape and surface coating) in Daphnia magna and Danio rerio at chronic exposure conditions, (2) study the influence of particle size, shape and surface coating of Au ENMs and size of SWCNTs on their trophic transfer along an aquatic food chain, and (3) study the potential for biomagnification of SWCNTs and Au ENMs in the food chain when mass and particle number concentration are considered as dose metrics and develop a model for predicting biomagnification of ENMs based on the proper dose metric. Bioaccumulation and biomagnification of Au ENMs will be quantified by measuring mass and particle number concentration using inductively coupled plasma (ICP)-mass spectroscopy (MS) and single particle (sp)-ICP-MS. (sp)-ICP-MS will also be used to differentiate between ionic and particulate bioaccumulation of Au ENMs. Laser ablation-ICP-MS will be used to in situ quantify cell-to-cell heterogeneity of the intracellular distribution of Au ENMs. Combination of thermogravimetric analyser with fourier transform infrared and gas chromatography/mass spectrometry will be optimized for quantification of SWCNTs in tissues. The novelty of the project is in developing approaches for quantification of carbon-based and metal-based ENMs in biological matrices. BTBnano includes both training me in new advanced techniques and transferable skills and the transfer of knowledge to the host institution. Results have the potential capacity to support the ENM risk assessment and provide room for further studies in nanotoxicology and nanomedicine. This project is in line with the EU policy to protect the environment and to minimise risks to climate, human health and biodiversity.

Mots clés : nanomaterials, ecotoxicology, risk assessment, bioaccumulation, biomagnification, fish, inductively coupled plasma mass spectroscopy, analytics, environmental science

Participants :
- Leiden University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet DRIPBEAT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Bacterial biofilms are closely associated with chronic infections, leading to much higher tolerance to antibiotics and treatment failures. New strategies for biofilm disruption are thus urgently required. Cyclic-di-GMP, a secondary messenger promoting biofilm formation, is a promising drug target. Only few compounds that reduce c-di-GMP levels and inhibit biofilms were identified so far, and most studies were conducted in vitro using standard medium and reference strains. In this project drugs will be repurposed for targeting c-di-GMP and biofilms to increase the antibiotic susceptibility of clinical Pseudomonas aeruginosa strains. Interdisciplinary approaches will be applied, combining next generation sequencing, gene expression pattern in synthetic sputum, protein structural modelling and computational drug docking, lung epithelial cell infection and murine model. This project will increase the accuracy of drug discovery based on c-di-GMP and significantly expand the skillset of an early career researcher with a strong background in the molecular mechanism of c-di-GMP pathway. The new knowledge in human cell culture and murine model obtained in this fellowship will be crucial for the researcher with a long-term interest in infection treatment. The host laboratory at Ghent University (UGent), a leading group in Europe investigating combination therapy against biofilms, offers an excellent atmosphere fostering both technical and transferable skills. The researcher will also benefit from the supervisor’s extensive research network and the numerous training programs provided by UGent to enhance the future career prospects. The research outputs will provide fresh insights into how genetic and environmental conditions influence c-di-GMP pathway (basic science) and how to select more appropriate compounds for biofilm treatment (applied science), and may also be subjected to clinical trials and attract industrial partners for wider applications.

Mots clés : pseudomonas aeruginosa, biofilms, cyclic di gmp, antibiotics, drug repurposing

Participants :
- Ghent University (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166320.0 €
Projet BONEZ (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Baltic Sea communities faced intense pressures from the 12th to 13th century AD, including colonization, forced conversions, and environmental change. The social resiliency of these communities in response to this crucial inflection point remains controversial. Did the external pressures catalyse the formation of a regional pan-Baltic identity? Or did splintered, hyper-local responses intensify differences between communities? The clearest measure of these seismic social shifts is how religious and mortuary behaviour changed in response, as communities create and negotiate a shared identity through the performance of ritual. The BONEZ project integrates multi-proxy osteological methods to investigate funerary and non-funerary ritual deposition of animals at five cemetery sites in Poland, Lithuania, and Kaliningrad before, during, and after colonization (1st to 13th AD). By combining long-established osteological methods with cutting-edge, high-resolution histological, isotope, and proteomic analyses, BONEZ reconstructs where, how, why, and with whom animals were treated and deposited in pre-Christian cemeteries. BONEZ will be the first study to unite the study of Baltic ritual activity with broader academic discussions of pre-Christian religion through rigorous scientific analysis of underutilized bone assemblages. This research has the potential to transform our perception of shifting tribal affinities using changes in ritual practice as an index of social resiliency. The first-of-its-kind integration of these methodologies as well as the regional and temporal scale of the analysis make BONEZ highly innovative and a key case study in the comparative osteology of complex skeletal assemblages. This research will have significant legacy benefits for the broader anthropological community as a state-of-the-art methodological blueprint for multi-proxy research on complex ritual deposits as an index of social resiliency transferable to any geographic or temporal context.

Mots clés : archaeological science, comparative osteology, bioarchaeology, zooarchaeology, bone histology, proteomics, isotope analysis

Participants :
- Cardiff University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet FINREALNETS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Banks’ exposures to similar asset groups could become an important source of contagion when combined with interbank network spillovers. The FINREALNET project aims at elaborating a common portfolio network-based stress-test framework that could find application in regular stress-testing exercises carried out by the regulator. Using an innovative DebtRank-based model FINREALNET suggests identifying Systemically Important Real Sectors (SIRS) at the euro area and test stabilizing effects of sector targeting macro-prudential tools. The Project will comparatively assess the resilience of European Banks to losses on common exposures pre- and post- QE, as the structure of overlapping networks is expected to change after the QE. The FINREALNET project is a perfect springboard for the Principal Investigator (PI) through the possibility to build durable research network, and acquire new skills which are complementary to her current expertise. Those new skills include research skills (theory and methodology), operational skills (algorithm writing), project management skills, language skills (German) and new data treatment skills (during the Secondment at the ECB). Moreover, working papers, presentations and recommendations for the regulator will improve the PI’s visibility as a young researcher and contribute to her research career. FINREALNET also builds a solid foundation for future collaborations. Finally, FINREALNET by its training and research program aims at promoting women’s integration in the domain of Economic research where a traditional gender gap persists.

Mots clés : financial networks, sustainability, financial system, stress test, real sector, interbank market, contagion, macro prudential regulation, sectoral capital requirements, large exposure limits

Participants :
- University of Zurich (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187419.6 €
Projet QUARTET (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Based on our understanding of the universe, we, who are made of matter, should not exist. This is due to the fact that the subatomic world is largely indifferent between matter and antimatter, predicting that they would be created in almost equal amounts in a big-bang scenario, and subsequently annihilate to form pure energy. This conundrum is called the baryon asymmetry problem. It is one of the major and most pressing unsolved questions in science today. One way of addressing this problem is to look for deviations between precision measurements and Standard Model predictions. However, a major limitation arises in the stage of comparison with theory due to nuclear-structure effects. Conducting measurements with exotic atoms overcomes this limitation, either by comparing measured properties between atoms and anti-atoms directly with no input from theory, or by measuring systems composed of particles with no internal structure. QUARTET - Quantum transitions in exotic atoms, will pursue both directions through two complementary experimental campaigns: 1. Muonium spectroscopy using the most intense low-energy muon beam at PSI. 2. Antihydrogen spectroscopy using the most intense low-energy proton beam at the ELENA beamline at CERN. QUARTET will focus on transitions in the microwave region of the electromagnetic spectrum, namely the classical Lamb-Shift, which for Antihydrogen has an added value: If no difference between matter and its counterpart is observed, this measurement will provide the first determination of the antiproton charge radius.

Mots clés : exotic atoms, microwave spectroscopy, anti matter research, muonium, low energy particles physics, qed test, anti hydrogen

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203149.44 €
Projet EFHHBBBMS (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Being at a major turning point in my career, after a rewarding postdoctoral fellowship in the United States, I’m applying to the MSCA-IF-2017 to ensure my return to Europe as an independent researcher in neurovascular biology. I built a proposal with the purpose of providing new understanding of Blood Brain Barrier (BBB) pathophysiology, particularly in the setting of Multiple Sclerosis. My hypothesis is that Desert Hedgehog-induced autocrine signaling in endothelial cells controls inflammatory lesion expansion via the regulation of intercellular junctions at the BBB through its co-receptor Gas1, and that this pathway may represent a new target for more effective therapies to prevent relapses and progression in Multiple Sclerosis. I choose to join the UMR Inserm U1034 to bring together my deep BBB knowledge and its unique expertise in Hedgehog signaling and vascular biology. Moreover the Bordeaux University, through its internationally recognized neuroscience campus, offers me an exceptional opportunity to develop fruitful collaborations with many distinguished researchers. My project is voluntarily built towards the exploitation of novel dynamic in vitro/in vivo BBB models requiring original microfluidic chamber design and 2-Photon live imaging (secondment in M. Nedergaard’s laboratory, Copenhagen), in vivo explorations of yet unpublished transgenic mice using high resolution imaging tools and the development of new molecules targeting original protein-protein interactions. As soon as I'll get exciting data, I will disseminate my work through seminars, international conferences and publications in high impact factor journals. Moreover, I will use the opportunities from both my hosting structure and Neurocampus programs to communicate to a wider audience (laboratory visits, meetings, Brain awareness week contributor). Ultimately, this fellowship will establish my emerging status of "young leader in neurovascular biology" with an international collaborative network.

Mots clés : blood brain barrier, hedgehog signaling, multiple sclerosis

Participants :
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 173076.0 €
Projet AxiBAU (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Being one of the great scientific triumphs of the 20th century, the Standard Model (SM) of particle physics is a key ingredient to our current world view. Despite its success, it, however, fails to solve a long-standing puzzle in cosmology that is crucial to our very own existence: Why does the Universe consist only of matter and not antimatter? This observation calls for baryogenesis: a physical process shortly after the Big Bang that creates an imbalance between matter and antimatter. In AxiBAU, I will shed new light on this problem, i.e., the baryon asymmetry of the Universe (BAU), and investigate a novel class of cosmological scenarios that relate baryogenesis to the physics of axions: a hypothetical type of particles that appear in many SM extensions. Recently, axions have received a great deal of attention, as their dynamics in the early Universe entail an extremely rich phenomenology. At present, the promising predictions of such cosmological axion models are, however, unreliable, as they ought to be constrained by the observed baryon asymmetry. This is where AxiBAU enters the game: In AxiBAU, I will establish the idea of axion-driven baryogenesis (ADB) as a main alternative to conventional scenarios of baryogenesis. To this end, I will: (1) Study the interplay of all baryogenesis mechanisms in the presence of axions. (2) Develop the numerical tools necessary to achieve a quantitatively reliable prediction of the final BAU. (3) Explore the constraints on other observables such as gravitational waves, primordial black holes, etc. (4) Embed ADB into a bigger picture, connecting it to ideas such as the relaxion, Higgs inflation, etc. I will implement AxiBAU at CERN under the supervision of the Head of the Theoretical Physics Department, Dr. Gian Giudice. I will collaborate with Dr. Gian Giudice as well as with other fellows and visitors at CERN, make use of CERN's unique conditions for research and training, and benefit from CERN's excellent infrastructure.

Mots clés : early universe cosmology, particle cosmology, baryogenesis, leptogenesis, axions, axion like particles, alps, axion, pseudoscalar, natural inflation, gravitational waves, primordial black holes

Participants :
- European Organization for Nuclear Research (Suisse) — Coordinator, beneficiary, Recherche, subvention : 187419.6 €
Projet ILBIB (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

Belonging – a concept at the heart of which lies a yearning for home – has domestic, regional, national, and even cosmopolitan implications. It was a particularly important concept in late-Georgian Britain (c. 1780-1830), during which time socio-political instabilities fostered an inward-looking impetus, prompting Britons to ask what home meant and what attachment to home entailed. This project looks at Ireland’s place in late-Georgian British imaginings of national and intranational belonging. Various forms of art – verbal, visual, and aural – will be analysed to show how the story of belonging overflowed formal limitations and became strategically embodied in art. To provide a foundation from which to branch out into various writers, artists, ideas, contexts, and works of art – which are selected across national and gender boundaries – I shall focus on the English poet William Wordsworth (1770-1850). Whilst Wordsworth’s writings about Scotland, Wales, and Continental Europe have been explored, his relationship with Ireland has yet to be fully studied. This project contributes to recent scholarly work on British travellers in pre-Famine Ireland, as well as to studies of Romantic writers’ Irish experiences. Focusing on the theme of belonging, this project revisits the debates, in humanistic geography, about the processes of mediation and remediation in which ‘space’ is turned into ‘place’, or, in another theoretical framework, into lieux de mémoire. But the central theoretical concern is to tease out the complex ways in which the story of belonging was framed in various cultural media and the socio-political implications of various forms of 'strategic storytelling'. This project will redress the marginalisation of Ireland in English literary studies, which reflects an abiding set of cultural prejudices against Ireland that are still perceptible even in twenty-first-century Britain and Europe, even after the Troubles in Northern Ireland had subsided.

Mots clés : william wordsworth, ireland, britain, belonging

Participants :
- Universidad Complutense de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 158121.6 €
Projet REDEBA (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Better managing energy and water resources along with development of water treatment technologies with low environmental impact and energy consumption has become more essential than ever due to water-energy nexus and growing environmental issues. This is mainly performed by using Reverse Osmosis (RO) technologies. However, RO presents number of environmental drawbacks such as effluents produced associated to the chemical regeneration of membranes. There is a strong necessity of secure and sustainable water supply, thus green technologies for water treatment are needed to safeguard the interests of a sensible use of water resources, to remain in strengthening environmental equilibrium as well as in the economic prosperity. Moreover, "Climate action, environment, resource efficiency and raw materials Challenge" in Horizon 2020 presents as one of its aims: positioning Europe as a global market leader in water-related innovative solutions. This project will revamp the Desalination Battery (DB) technology, the original and innovative aspects of the proposal lies in taking up the challenge to shift the knowledge frontier and develop a Cl- capturing electrode. Thus, the aim of this project is to develop a full concept for the next-generation DB, addressing the issue of new materials for anion capturing and cell design, which gives lower energy losses and more flexible operation. In order to do so, development of flexible and anionic electrode materials will be investigated, as well as the impact of operation variables on desalination degree and on energy consumption in dependence of the cell design. The multidisciplinary nature of the project is strong, involving a combination of electrode materials development, electrochemistry and engineering (scaling-up, cell and module design). This project is in line with the EU strategy for the sustainable development of water resources and desalination.

Mots clés : seawater desalination, ion selectivity, anionic electrode, batteries

Participants :
- University of Bremen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162806.4 €
Projet ETFA (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Between 237 and 202 BC, the Carthaginian Empire due to both its territorial ambitions and, above all, its conflicts with Rome and several indigenous peoples of the Iberian Peninsula and North Africa, was forced to keep large numbers of troops permanently mobilized. This military-political circumstance led to a series of major changes in many areas of the Carthaginian economic, political and social system. Through this project we will analyze in detail the extent to which the military mobilization affected agriculture, the very basis of the ancient economy, and the related politics adopted by the ruling elites of the Carthaginian Empire. This project, therefore, includes a quantitative study of the productive capacity of the Carthaginian empire in the late third century BC; an analysis of the logistics during the Second Punic War (218-201 BC); an appreciation of the relationship of war veterans with agricultural production at this chronological context; and a comparison of these results with those obtained in a specific casus: a survey of part of the territory under the rule of the Phoenician city of Utica, a North-African city under the Carthaginian rule.

Mots clés : rural archaeology, second punic war, carthage, western mediterranean, economy, society

Participants :
- Ghent University (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €