Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet LeishMal (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Malaria and Visceral Leishmaniasis (VL) are prevalent parasitic diseases presenting substantial healthcare challenges in tropical and subtropical endemic regions. They share similar geographical distributions, increasing susceptibility during co-infections. Utilizing my multidisciplinary expertise in molecular and cellular biology and parasitology, this research proposal aims to establish a novel murine co-infection model to elucidate the cellular and immunological events during concomitant infection with Plasmodium and Leishmania parasites. Unlike previous studies, we seek to evaluate how Plasmodium affects VL pathology and how Leishmania impacts malaria, providing insights into the disease progression dynamics. Furthermore, we will delineate the immunological responses in single- and co-infected mice, shedding light on host immunity in co-infections. To generate a robust and reproducible murine co-infection model, we will optimize infection parameters, including inoculation routes and parasite doses. The co-infection timing will also be systematically manipulated to discern its impact on disease outcomes. This endeavor holds significant potential to advance our understanding of co-infection biology and contribute significantly to the development of clinical management strategies and therapeutic interventions tailored for co-infections in endemic regions. The host institution’s state-of-the-art facilities and the host laboratory’s extensive experience in investigating co-infections involving Plasmodium and other pathogens ensure an ideal environment for achieving the goals. Ultimately, this project will enable me to become proficient in the field of co-infection biology, encompassing all phases of malaria, including liver, blood, and insect stages. Overall, the research proposal leverages a carefully controlled murine model to illuminate the intricate dynamics of co-infections, contributing to improved healthcare outcomes in regions where these diseases prevail.

Mots clés : malaria, visceral leishmaniasis, co infection, immune response, leishmania, plasmodium, experimental mouse model

Participants :
- Gulbenkian Institute for Molecular Medicine (Portugal) — Coordinator, beneficiary, Recherche, subvention : 156778.56 €
Projet QDHassay (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Nucleic acids are intrinsically polymorphic. Apart from the Watson-crick duplex, guanine-rich sequences can form G-quadruplex (G4) structures, which have become attractive targets for small molecule ligands. It is now proven that G-quadruplexes can form in cells. Today most biophysical and structural/ligand binding studies are carried out in dilute aqueous solutions and the presence of artificial crowding agents/cosolvents. Still, recent works suggest that the folding of G4s may differ in the cellular milieu context due to the agents' limitations. Thus there is an immense need for in-cell-based structural biology approaches. In the proposal, I aim to address critical milestones leading to the bioactive conformation inside the cell and the development of effective/specific G4 targeting drugs using an essential sub-class of G4 structures as a paradigm, namely quadruplex−duplex hybrids (QDH-hereafter). We will focus on low- and high-resolution spectroscopic approaches and mass spectrometry-based ligand screening assays characterizing ligand-QDH interaction. On the methodological part, we will develop in-cell NMR in "native" conditions (starting from unfolded conformation: denovo folding) and propose a ligand screening assay inside the cellular system. Our project will contribute to unveil fundamental principles of nucleic acid folding. It will also foster collaboration between two European institutes specialized in complementary biophysical and structural approaches to study biomolecular folding. In a nutshell, the Maria Skłodowska Curie fellowship will flourish my scientific excellence and the resilience needed for my original ideas to become a reality and communication and public engagement skills across cultures and disciplines.

Mots clés : nmr, in cell nmr, nucleic acids, quadruplex duplex hybrid, dna drug interaction

Participants :
- Université Masaryk (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166278.72 €
Projet YPB (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Recent discoveries of numerous and diverse exoplanetary systems and their debris discs have revolutionized our understanding of how planets and planetesimals form. One of the exciting recent developments is detection of a large number of young systems which appear to be hosting belts of planetesimals, yet also unexpectedly show high amounts of gas. To explain these observations novel computational models must be developed, which take into account all key physical processes shaping the distribution of dust in these systems. I propose to use a kinetic model of collisional evolution of planetesimals and dust, combined with models of dust evolution due to gas drag and radiation pressure, and models of gas structure shaped by viscous evolution and dispersal. To do this I will extend the capabilities of a kinetic model previously used in studies of gas-free debris discs to account for dynamics of small dust grains in the presence of a gaseous disc. This will allow to model the entire range of body sizes, from dust to planetesimals, in a self-consistent way. The project will require knowledge of collisional planetesimal belts as well as of the proto-planetary environment, and this knowledge will be directly drawn from the existing research experience of the candidate. The project will generate a transfer of knowledge to the host institution while developing the candidate’s theoretical and technical expertise. The results of the project will be of wide use to the planetary science community, as they will help to interpret future observations of young planetary systems, to constrain the process of protoplanetary disc dispersal, and determine properties of dust and gas that may be accreted onto planets in the last stages of their formation.

Mots clés : protoplanetary discs debris discs planetesimal belts

Participants :
- Université de Belgrade (Serbie) — Coordinator, beneficiary, Recherche, subvention : 140187.84 €
Projet AKEEMC (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The main thesis of my postdoctoral project, entitled Ascent to the Kingdom: The Eucharistic Ethics of Maximos Confessor, is that Maximos subscribes to a kind of eucharistic ethics in which the human is called to offer back the gift of being in the form of gratitude (eucharistia) culminating in the perfection of being, the unificatory state of deification. I argue that Maximos’ ethics is fundamentally an ethics of Oneness, of the progressive realization – on a personal and cosmic level – of the fundamental unity at the heart of reality. This unitary ethics is summed up in the inseparability of virtue & contemplation. Together, these practices work to overcome the inner fragmentation of the self and the outer divisions of the world introduced by ignorance and sin. All the virtues – be it humility, forbearance, detachment, charity, love, fasting, contemplative prayer, vigils, worship – represent means of overcoming the instability of a life centred upon the finite self (the ego), leading to a more grounded God-centred life. The ethical life, in essence, represents the overcoming of divisions and the progressive (re)unification of self and world culminating in union with Christ and the Trihypostatic God who alone is One. The inherently unificatory practice of the virtues (as manifold expressions of love) is corroborated by contemplative insight into the oneness of God, nature, and the human person. Virtue and contemplation culminate in the unity of divine-human love (agapē).

Mots clés : patristics, ethics, neoplatonism, maximus confessor, asceticism, contemplation, mysticism, anthropology, orthodox theology, philosophy, history of ideas, the virtues

Participants :
- Université de Belgrade (Serbie) — Coordinator, beneficiary, Recherche, subvention : 140187.84 €
Projet MICRO-INSERT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Wood is the only renewable construction material and holds great promise for sustainable built environments of the future. However, its combustibility is a major limitation. The drawback of using traditional fire and flame retardants is the toxicity and volatility of some of their components and the loss of chemicals by leaching, leading to poorer performance. Mineralisation of wood offers a green alternative, but current strategies often require a costly technical setup for supercritical gases or the use of harmful chemicals to achieve the deposition of minerals deep inside the wood structure. Biologically induced mineralisation is a widespread phenomenon occurring in all kingdoms of life. In recent years, microbially induced calcium carbonate (CaCO3) precipitation has been proposed as a potential solution to address many environmental and engineering issues related to the enhancement of inorganic materials (protection of concrete, soil consolidation). However, the potential for using fungi has received relatively little attention compared to bacteria. The MICRO-INSERT project will investigate the feasibility of using fungi as CaCO3 carriers to develop a novel bioinspired mineralisation process for biobased building materials. Wood as a highly porous, three-dimensional organic scaffold will be mineralised to create hierarchically structured organic-inorganic hybrid materials with novel properties, including improved fire resistance. The proposed bioinspired treatment incorporates ideas for sustainable materials design, circularity, reduction of toxicity, and lowering the negative impact on the environment. The MICRO-INSERT project will stimulate innovation and knowledge transfer between the host and ER by building a solid research network, organising events, mentoring young researchers, and managing projects. The ER will gain research and scientific skills and acquire a new set of competencies to reach professional maturity and independence after the fellowship.


Participants :
- Université du Littoral (Slovénie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171399.36 €
Projet MTRoute (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Rising population and living standards have caused pollution, water scarcity, and resource shortages. To mitigate these issues and adopt sustainable development methods, we need innovative environmental technology. Bioelectrochemical systems (BES) are a rapidly growing and versatile technology that exploits the ability of electroactive microbes to conduct electron transfer between electrodes to oxidise or reduce substrates, such as organics present in wastewater, opening up a wide range of applications for wastewater treatment, nutrient recovery, and bioenergy production. The rate at which electron transfer occurs is the key process behind the development of BES and is one of the defining factors of the implementation of BES on a large scale. Recent research has revealed that the porin-cytochrome complex MtrCAB, which is responsible for electron transport across the outer membrane, is found in a wide variety of microbes, including several electroactive bacteria that participate in BES, demonstrating the potential significance of MtrCAB for extracellular electron transfer. MTRoute is aimed to provide information on the performance of MtrCAB from diverse bacteria in electron transfer, as well as identify the molecular mechanisms and factors that can enhance electron transfer rates. Synthetic biology tools will be used to incorporate these insights to the extensively studied electroactive microbe Shewanella oneidensis MR-1 to push forward the practical implementation of BES. Towards this aim, MTRoute will rely on a multidisciplinary research project that will based on the ER's expertise in bioreactor application, the host team expertise on evaluating electron transfer processes of multiheme cytochromes, and on the secondments' supervisor expertise in genetically modify electroactive microbes. The success of MTRoute will contribute to tackle several UN sustainable goals and build a bio-based economy, one of the strategic priorities set by the new Europe 2030 program.

Mots clés : extracellular electron transfer bioelectrochemical systems electroactive organisms genetic engineering multiheme cytochromes

Participants :
- Université nouvelle de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
- Université du Minnesota (system) (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PATH (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

“What is the drug of choice for the given condition?” is the most important question raised by patients and clinicians at the point of care. The use of systematic reviews to answer this question, accompanied often with pairwise or network meta-analysis, ensures that decisions are informed by the best available evidence. However, in many healthcare areas we are moving towards the era of treatment pathways, in which not only a single treatment but a sequence of treatments can be the optimal choice for patients. Despite the important advances in methodology of evidence synthesis, treatment adaptations, such as modifying dose, switching, adding or discontinuing treatments are rarely informed by evidence. The overarching research aim of this project is to develop and test a framework for deriving the optimal treatment pathway. To this aim, I have set the following objectives: a) develop the statistical framework to compare alternative treatment pathways and b) evaluate the framework by developing methods to make it useful and applicable to clinical practice. I have devised the concept that treatment pathways can be seen as a combination of components, in which, however, sequence needs to be taken into account. As a first step, I will thus use component network meta-analysis. I will subsequently incorporate advances from clinical trials, dose-response, time-course models and prediction models, among others. I will develop PATH using as an example schizophrenia, where I will model treatment switching, increasing dose and/or adding treatment and will produce relative effects between all alternative treatment pathways. PATH will provide a much-needed methodological toolkit to healthcare practitioners, patients and policy makers, while it has the potential to have a profound impact on drug manufacturing; manufacturers can be informed by the position of similar drugs in the best treatment pathways, so that they can target their newly to be developed drugs accordingly.

Mots clés : systematic reviews meta analysis evidence synthesis evidence based medicine network meta analysis

Participants :
- Université Aristote de Thessalonique (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 197263.68 €
Projet ETD (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

“Environmental Turn of Dance: Convergence of Therapeutic Practice, Art Creation with AI and Community Practice” (ETD) is a groundbreaking research endeavor poised at the nexus of dance studies, environmental philosophy, and AI technology. The project seeks to investigate how dance can effectively generate awareness of, and proactive responses to, the challenges posed by climate change. Specifically, the research will evaluate existing initiatives, performances, and collaborations that integrate dance and climate change and identify the ways in which dance can contribute to climate change education, advocacy, and the promotion of sustainable practices in Malta. With urgency stemming from contemporary ecological challenges, ETD aims to redefine the role of dance as a catalyst for ecological consciousness, addressing the why of our environmental crisis in a novel, embodied manner. The current moment demands immediate action in reshaping our relationship with the environment. ETD acknowledges the pressing need to infuse environmental awareness into artistic expression. This urgency aligns with global concerns for climate change and ecological well-being, propelling us to address environmental issues creatively, fostering a sustainable future. Methodologically, this project seeks to unravel the intricate interplay between dance and the natural environment, shedding light on unexplored dimensions. Moreover, ETD pioneers the integration of AI technology into dance research, emphasizing innovation and collaboration. This approach marries creative artistry with cutting-edge tools, enabling dynamic exploration of ecological themes. ETD exemplifies my profound interdisciplinary expertise. My recent international projects have skillfully developed intersectional knowledge, bridging dance studies, environmental philosophy, AI technology. Therefore, ETD will build TRIPLE-I dimension (International, Intersectoral and Interdisciplinarity) and integrate diverse expertise.

Mots clés : dance performances on climate change, environmental philosophy, eco somatic, ai choreography, community engagement

Participants :
- Malta College of Arts, Science & Technology (Malte) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177251.52 €
Projet OrganiQ (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The growing demand for organic poultry, particularly chickens, presents a challenge for the industry to offer sustainable alternatives while ensuring animal health under less controlled organic conditions. Organic quail farming emerges as a viable option, but the absence of controlled environments makes quails more prone to health and productivity issues. Nutraceuticals like B vitamins offer a promising solution, yet no studies have determined the optimal supplementation levels for organic quails under these conditions. OrganiQ addresses this by investigating the effects of thiamine (B1), pyridoxine (B6), and cobalamin (B12) to improve quail growth (WP1), physiological responses (WP2), gut microbiome dynamics (WP3), and meat and egg quality (WP4). The goal is to identify the ideal dosage and combination of these vitamins to boost productivity, health, and product quality in non-controlled environments. Using an interdisciplinary approach that integrates animal production, microbiology, bioinformatics, and food science, I aim to develop evidence-based dietary recommendations for organic quail farming. Selçuk University, known for its expertise in avian production and led by Prof. Olgun, provides the perfect environment for this research. Additionally, secondments at the University of Salamanca and Estación Tecnológica de la Carne will enhance my skills in microbiological and meat quality analysis while further developing my leadership capabilities. OrganiQ will equip me with practical experience and interdisciplinary knowledge, preparing me to manage multidisciplinary teams and pursue European funding opportunities, ultimately enabling me to establish my own research group in sustainable animal production.

Mots clés : b vitamin supplementation, quails, organic avian production, avian productivity, avian health, egg and meat quality, nutraceuticals in poultry, avian gut microbiome, sustainable livestock practices

Participants :
- Instituto Tecnológico Agrario de Castilla y León (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Selçuk University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165205.2 €
- Université de Salamanque (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet GenTeR (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This historical research, that innovatively brings together a transnational and gender approach, investigates the ways in which theatre activities in Trieste shape collective identities and imagined communities linked to nation and empire, and asks how these identities, which have so profoundly marked European history, are interlaced with gender roles. The research spans from the establishment of the Austrian Littoral (1814) to the outbreak of World War I (1914), that leads to the formation of nation states. Trieste is an interesting case study because along a century characterized by the development of national movements in Europe, this town is a cosmopolitan emporium city and the main port of the Habsburg multi-national empire. The research sheds light on the theatre because during the century theatre in Europe plays a central role in the construction of the collective imaginary and in the sentimental education of both men and women. The project, that matches a cultural-historical with a social-historical analysis in an original way, looks not only to the visual and artistic aspect of the performance, but also to the networks of theatre workers (onstage, back stage and offstage), invisible to the audience but essential to the performance and to the dissemination of repertoires, images and symbols. Most of the research will be spent in Trieste, whose archives will disclose ties between the city theatres and other European theatres. To shed light on the theatrical circuits in the Adriatic Littoral, in which Trieste was included, shorter fieldwork periods are planned in Venice and Zara, whose state archives preserve important theatre collections. The project will be developed with the historian prof. Marta Verginella, an expert in plurilingual contexts in border areas between Italian, German and Slavic worlds, and hosted by the Faculty of Arts at the University of Ljubljana (UL). A placement will take place at the Civico Museo Teatrale “Carlo Schmidl” in Trieste

Mots clés : social history gender history cultural history 19th century trieste european identity theatre repertoires onstage workers backstage workers cosmopolitan nationalism

Participants :
- Université de Ljubljana (Slovénie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 248196.9 €
- Comune di trieste (Italie) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €