Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet LASER4Mg (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The overall aim of the project is to obtain the most optimum laser characteristics that will improve the ability to process Mg alloys for laser based additive manufacturing method, which currently suffers immensely due to excessive evaporation of the powder feedstock. Lasers are a form of monochromatic electromagnetic radiation, that interact with each metal differently. In selective laser melting (SLM) process, when laser energy is applied to the Mg powder, two primary processes occur: absorption and reflectance. The laser wavelength determines the degree of absorption in the metal powder. Due to low absorbance of traditional yttrium doped fiber laser in infrared range, and low thermal conductivity, Mg processing requires using high power lasers that leads to rapid evaporation of Mg when the laser hits the melt pool. To accomplish these goals, optical spectral absorbance properties of magnesium and its alloys in various forms (plate, block, powder) will be studied using UV-VIS-NIR spectroscopy. Effect of laser characteristics such as mode, power and wavelength on the absorbance response and process stability will be characterized. The impact of powder particle size distribution, plate thickness, surface quality, alloy compositions on laser-material interaction will be studied. The results will be used to obtain the highest success process window.  The project will create valuable knowledge for use in the field of SLM of Mg alloys. The existing scientific gaps and technological challenges associated with laser treatment of Mg alloys will be filled and sustained by commercialization by the researcher's current employer. The research plan is designed to solve an outstanding problem in the industry and will improve the long term employability of the researcher with his employer in Europe. The potential resulting technology will be a leap in the field of laser treatment of magnesium, increasing industrial capacity in EU and stimulate further R&D&I efforts. host name

Mots clés : laser material processing, selective laser melting, magnesium alloys, aerospace applications, spectral absorbance reflectance

Participants :
- Amazemet sp. z o.o. (Pologne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Fraunhofer-Gesellschaft (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Lettonie (Lettonie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162499.2 €
Projet ROMANCE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The impacts of climate change are now more pervasive than ever before in human history. Marine ecosystems have been particularly impacted by climate change, with several of them being at the brink of collapse. As a response, the international efforts to reduce carbon emissions have never been so ambitious. However, even in the most optimistic CO2 emission scenarios, the planet will continue to warm and experience the effects of climate change over the coming decades. For this reason, several international conservation targets have been set to maintain the resilience of marine ecosystems to climate change. Despite these calls, resilience research has been hampered by a lack of coherent ways to quantify it and the limited availability of empirical data. ROMANCE overcomes these limitations by taking an interdisciplinary approach to understand and predict the resilience of threatened Mediterranean marine ecosystems to current and future climate change. More specifically, in ROMANCE I will (1) study the resilience of marine communities to past marine heatwaves, (2) develop a deep algorithm to detect early warning signals of collapse and (3) use cutting-edge to predict the resilience of marine communities to different climate change disturbances. The results arising from ROMANCE will provide relevant information for the application of EU directives, especially related to climate change adaptation and coastal resilience, as well as a great leap for the applicant’s career, with valuable training and high-level publications expected.

Mots clés : climate change, conservation, corals, marine heatwaves, mediterranean, regime shifts, resilience

Participants :
- Université de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
- Université de Montpellier (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet THANAFSI (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

The THANAFSI project aims to contribute to the Sustainable Development Goals of the UN Agenda 2030 by improving the understanding of the behavior of infrastructures of current worldwide social interest through the analysis of suitable mathematical models. The project will tackle two main fluid-structure interaction (FSI) problems arising, respectively, in civil and coastal engineering: (1) the stability of suspension bridges under the action of the wind, (2) the impact of ocean waves on oscillating water columns (OWCs). Three research lines will be developed: (a) study the global existence and uniqueness of the solution to a 2D wind-bridge model in non-symmetric configurations for arbitrarily-shaped structures and focus on the asymptotic stability of the equilibrium state, (b) study the existence and uniqueness of the solution to a 3D wind-bridge model, both in symmetric and non-symmetric configurations, (c) study the local well-posedness of 1D Boussinesq-Abbott system in presence of an OWC and estimate the order of the existence time. The achievement of these challenging goals will move the boundaries of the mathematical comprehension of FSI problems. Nonlinear effects will be taken into account in (a)-(b) improving the comprehension of wind-bridges interaction in order to prevent catastrophes and design reliable suspension bridges. Both nonlinear and dispersive effects will be considered in (c), advancing the mathematical knowledge of wave energy converters, crucial to increase their energy efficiency. The THANAFSI project will be carried out by the Researcher, who worked during his PhD on the mathematical analysis of floating structures in shallow water waves, and then as a postdoc moved on to thin film approximations for fluids in porous media. The Researcher will interact with the Supervisor, a prominent expert in mathematical models of suspension bridges and in analysis of FSI problems, with whom he is currently collaborating.

Mots clés : fluid structure interaction, elasticity pdes of suspension bridges, navier stokes equations, water waves equations and structures, boussinesq abbott system, qualitative properties of solutions of pdes

Participants :
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- Université libre de Bruxelles (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Montpellier (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Cocco-Next (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Human CO2 emissions are critically poisoning the earth's climate. However, sedimentation by marine primary producers contributes greatly to carbon sequestration, with coccolithophores, unicellular marine algae with cell envelopes composed of CaCO3, being the key contributors. Nevertheless, the extent of the biogeochemical impact of coccolithophores is largely unknown. They have a dual life cycle and can grow as both haploids and diploids, but past research has focused mainly on the diploid phase. Moreover, knowledge of coccolithophores is almost exclusively limited to a single species that is distributed worldwide, and can form blooms visible from space. However, this species is peculiar in many biological aspects and does not calcify in the haploid phase, therefore we need to develop more model organisms to represent impact of coccolithophores on the carbon cycle. In this action, my objective is to understand how the physiological acclimations of the coccolithophore life cycle phases allow them to inhabit different ecological niches. I will implement a multidisciplinary approach to investigate two levels of complexity: how environmental factors influence physiology and which genes contribute to distinct genetic programs. To this end, I will work on a widespread coccolithophore species that calcifies at both life cycle phases. I will characterize for the first time how photosynthesis (light-driven CO2 fixation) and photoprotection (dissipation of excess energy) differ between the two phases, and determine which environmental conditions trigger ploidy transitions. To investigate the underlying genetic factors, I will then sequence the genome and, in both phases, the transcriptome. Overall, the ambition of the Cocco-Next project is to provide important insights into the interplay between life cycles, ecological niches, and biological CO2 sequestration and beyond, create novel, interconnected and open datasets that will be invaluable to the oceanographic community.

Mots clés : coccolithophores, photosynthesis, life cycle, haplodiplontic, genomics, transcriptomics, environmental conditions

Participants :
- Institut Ruđer Bošković (Croatie) — Coordinator, beneficiary, Recherche, subvention : 161889.6 €
Projet BITE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

We are what we eat. Changes in diet triggered the progressive simplification of the cranio-dental system from our ancestors until the ultimate adaption of our species. Compared to ours, Neanderthals possessed a complex dental morphology interpreted as an adaption for mechanical loads. However, how morphometric dental traits evolved to adapt to diet or cultural habits as well as the pace of these changes throughout human evolution are unknown. BITE represents the first attempt to investigate complementary dental proxies (dental wear, morphology, and enamel thickness) in a constricted, phylogenetically related, and chronologically consecutive European Pleistocene sample, including the populations from the UNESCO-sites of Atapuerca (H. antecessor and Sima de los Huesos) and Neanderthals, for a comparison with a modern human sample, including modern hunter-gatherers, medieval and contemporaneous groups. BITE goes beyond the state of the art as it proposes an innovative, interdisciplinary, and holistic approach employing biological data, high-resolution and 3D image, and biomechanical tools, combined with pre-existing dietary information to provide unprecedented insight into how our ancestors adapted to dietary and/or behavioral demands. The Applicant is an ideal candidate to conduct this multidisciplinary project as she has knowledge in dental anthropology, palaeoanthropology, palaeopathology, and 3D medical imaging, and she will receive training-through-research in biomechanical tools to expand her expertise. This fellowship will position her as a dynamic and independent researcher, being one of the few experts in Biomechanics for the study of hominin evolution in Europe. BITE also represents an opportunity to make visible to the society and scientific community the excellence of Europe's science as a world reference for Human Evolution studies and enhance the collaboration with the private sector (e.g., dentistry) for the design of more resistant artificial crowns.

Mots clés : dental palaeoanthropology, high resolution 3d imaging, biomechanics, diet, culture, environment, european pleistocene hominins, human evolution

Participants :
- Université Monash (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- National Research Center on Human Evolution (Espagne) — Coordinator, beneficiary, Recherche, subvention : 283433.76 €
Projet BosLong (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

This project addresses the effects of thermal particles on the condensate phase for bosons, focusing on systems with long-range interactions at finite temperatures. We explore ultra-light bosonic particles as dark matter candidates in cosmology and extend the study to cold atomic systems under dipolar interactions. Our approach involves a recently developed theoretical framework using non-equilibrium quantum field theory to describe two-component bosonic systems, condensed and thermal, under long-range interactions. We will create a specialized simulation code to study the dynamics of condensate and thermal particles in both cosmological and atomic contexts. This code aims to fill critical gaps in current research and will be made publicly available with detailed documentation. The project will involve two main objectives: (1) developing and validating this code, and (2) investigating pivotal problems in the dynamics of dipolar and cosmological quantum gases. By comparing results with existing methods and exploring new phenomena, this research seeks to provide significant advancements and uncover valuable analogies between ultracold atom and dark matter studies.


Participants :
- Institute of Physics (Pologne) — Coordinator, beneficiary, Recherche, subvention : 179006.16 €
Projet COLLY (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Upon external mechanical loading, amorphous solids initially deform elastically, but for large enough applied stress they may fracture or flow as a plastic fluid. This transition, known as yielding, is one of the most fascinating open problems in condensed matter statistical physics. In fact, the exact nature of the transition is still unclear: some systems show abrupt (brittle) yielding (e.g., in oxide glasses) while others, such soft gels or foams, display ductility with a smooth and gradual increase of plastic deformation. A unique picture of the processes at play is yet missing and recent models and theories claim experimental support. Here I will use a use a novel colloidal glass to explore the yielding transition and its properties. Colloidal glasses are controlled through their volume fraction: it plays the same role of temperature in molecular ones, but it is much more difficult to precisely tune. I will overcome this difficulty exploiting a mixture of nanoparticles and non-colloidal polymer mesogels. The mesogels swell/shrink as a function of temperature, controlling the available ‘free’ volume for the (temperature-insensitive) nanoparticles. This approach allows for an unprecedented precise control of the volume fraction in a colloidal glass without changing particle-particle interaction or their size (e.g., in microgels). The versatility of the system will be exploited to investigate plastic activity for different level of glass equilibration and external applied stresses thanks to cutting-edge experiments involving rheology, time- and space- resolved visible scattering and synchrotron-based X-ray photon correlation. These approaches will be combined to obtain a comprehensive picture of the processes at play, allowing for a ground-breaking study from inter-particle distances up to macroscopic sizes. The yielding transition will then be tackled from a new point of view, potentially elucidating its nature and confronting emerging theories.

Mots clés : glasses, glass transition, elasticity, plasticity, yielding, x ray scattering, x ray photon correlation spectroscopy, xpcs, dynamic light scattering, photon correlation imaging, rheology, pnipam

Participants :
- European synchrotron radiation facility (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Montpellier (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226420.56 €
Projet CONVO (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

High-grade serous ovarian cancer (HGSOC), which is the most aggressive type of ovarian cancer, is characterized by the mutation of gene TP53 and extensive copy number variations (CNVs). HGSOC tumors typically show an initial favourable response to standard treatments, however they often acquire resistance and relapse. Currently, there is a need for new therapeutic approaches to combat emerging drug-resistant subpopulations. Although, the scarcity of common targetable oncogenic mutations has complicated the development of directed therapies, the study of CNVs offers a promising opportunity to find new mechanisms of resistance and develop alternative treatments, as it has been described how CNVs can model clonal fitness and therapeutic resistance in other types of cancer. Here, I will explore the impact of the CNVs on the treatment response of HGSOC patients and their distal effects on the transcriptome using convolutional neural networks. This complex machine learning model will be trained with the largest available longitudinal cohort of HGSOC samples at the single-cell resolution and will reveal which CNVs, and their specific combinations, have a relevant role in shaping the HGSOC tumours upon treatment. Employing a systems biology approach I will identify convergent phenotypes within these relevant CNV profiles and then validate their effects on treatment using data from both external cohorts and drug-treated patient derived organoid models. This novel approach enables revealing resistance mechanisms driven by complex genotypes, and thus allows finding specific vulnerabilities to combat emerging resistance in HGSOC.

Mots clés : copy number variation, ovarian cancer, single cell transcriptomics, machine learning

Participants :
- Université d'Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet TEATIME (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Colorectal cancer (CRC) is the second most common cancer and nutrition influences its prevalence. CRC originates from intestinal stem cells (ISCs) and is initiated by specific genetic alterations, which influence cell growth, proliferation and fate. How nutrient signalling within the mutated ISCs and the surrounding tissue environment influences the early steps of CRC tumorigenesis and whether genetically distinct tumour types react differently to nutrition remains poorly understood. The host laboratory has recently discovered a mechanism that couples nutrient-dependent control of ISC size to cell fate regulation. As distinct tumorigenic genotypes display different fate profiles, I hypothesise that nutrient-dependent control of ISC size differentially modulates phenotypes of CRC-associated gene variants. To test this, I will utilise the Drosophila midgut model as well as the fully defined Drosophila diet to systematically uncover the nutrient vulnerabilities of several ISC-derived tumorigenic genotypes. As my preliminary data implicates the role of nutrient signalling in the tissue environment, I will develop a new dual gene expression tool, enabling simultaneous genetically control of the tumour and the neighbouring tissue. I will combine transcriptomics, metabolomics and organ-wide imaging with quantitative image analysis to mechanistically address how changes in nutrient signalling and metabolism of oncogenic and surrounding wild-type cells influence tumour initiation. To test the conservation of the main findings in Drosophila, I will utilise the CRC models of mouse intestinal organoids. Collectively, this project will address how nutrient regulation of ISCs and their tissue environment will affect the initial events of CRC tumorigenesis.

Mots clés : stem cell, intestinal cancer, drosophila, nutrient sensing, metabolism

Participants :
- Université d'Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet Protambbody (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The amyloid-beta (Aβ) protein arises from the sequential proteolytic cleavage of Aβ precursor protein (APP). The accumulation of Aβ oligomers has been regarded as the causal factor of Alzheimer’s disease (AD). Basal metabolic production of the Aβ peptide is typical in healthy people, and its production rate is normally lower than its rate of clearance. In AD, the uncontrolled accumulation of toxic forms of Aβ stemming from problems in its clearance and degradation results in memory loss, chronic neuroinflammation and neurodegeneration. AD is a leading cause of disability and death both in Europe and the world, and currently has no cure or clinically-proven disease-modifying therapies. There are over 10 million new cases of dementia each year worldwide (up to 80% of which are due to AD), implying one new case every 3.2 seconds. In Europe, about 10 million people currently suffer from this disease and about 50 million in the world; with these estimates projected to double by 2050. Thus, the identification of novel disease-modifying therapies has become very critical to eradicating AD from Europe and the world. My project proposes a radically novel approach in the AD field of utilizing the body’s cellular waste disposal system to selectively degrade Aβ peptide, the causative agent of AD. This is in sharp contrast to the current approach of immunization against the Aβ peptide, which has repeatedly failed to yield any cure or disease-modifying therapies for AD.  This project will aim to identify the specific cytotoxic Aβ peptides responsible for neuroinflammation and neurodegeneration in human induced pluripotent stem cells and target these peptides for degradation by the ubiquitin proteasome system. Emphasis will be on the cytotoxic Aβ peptides of intracellular origin as emerging targets in AD. This research will be conducted at the University of Helsinki, Finland, followed by a non-academic placement at Roche Diagnostics GmbH.

Mots clés : amyloid beta, nanobody, ubiquitin ligase

Participants :
- Roche Pharma AG (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université d'Helsinki (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269418.0 €