Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet hnRNPs-DNA damage (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

DNA double-strand breaks (DSBs) are toxic lesions that must be efficiently repaired to maintain genome integrity. Following DNA damage, cells activate a multi-layered signalling and repair network termed the DSB response. Emerging organizers of this DSB response are various RNAs and RNA-binding proteins, which display characteristic localization dynamics at the damaged-chromatin. The laboratory of Stephanie Panier recently showed that many heterogeneous nuclear ribonucleoproteins (hnRNPs) are actively excluded from damaged chromatin soon after the induction of DSBs. The exact purposes of hnRNP exclusion and the underlying regulatory mechanisms remain to be determined. In my postdoctoral project, I propose to study why and how hnRNPs are excluded from damaged chromatin. To this end, 1) I will characterize the exclusion properties of the hnRNPs at DSBs using cellular models and unique genetic and microscopy approaches. 2) I will also identify protein and RNA complexes associated with hnRNPs at DSB sites using proximity labelling proteomics and RNA-sequencing approaches. In studying these hnRNPs, I will unravel the new mechanisms by which RNAs help to organize the DSB response. The combination of state-of-the-art cell biological and omic approaches will enable me to go well beyond the current knowledge of the field to characterize novel factors and mechanisms that coordinate RNA biology at DSB sites. Since genome instability and defects in RNA metabolism are both directly linked to the pathogenesis of cancer and also neurodegeneration, my findings will have direct implications for human health.

Mots clés : genetic instability, dna double strand break response, hnrnps, rna, rna binding proteins

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet OptoEpiC (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Collective cell motility states, such as multicellular flocking and jamming, are active matter states that play important roles in development and disease. However, much of the dynamics of these collective states remains to be discovered. The goal of this proposal is to use optogenetics to control and understand collective cell dynamics. Optogenetics allows to control cell mechanics with unprecedented temporal and spatial precision by photoactivating the molecular machinery that regulates cell protrusion and contraction on-demand. By combining optogenetics with traction force microscopy, we will first study how single epithelial cells reshape their traction forces in response to activation of RhoA, Rac1 and CDC42. We will then investigate collective coordination of intrinsic forces and movements in response to different patterns of photoactivation of these RhoGTPases. Specifically, we will induce and steer flocks made of several cells, and we will jam/unjam well-defined regions in monolayers near the jamming transition. Active gel models will help us identify characteristic mechanical profiles of single- and multi-cellular motility. The project will yield new approaches to understand and control epithelial dynamics at the mesoscale, opening new avenues at the intersection of active matter physics and biology.

Mots clés : cell migration, traction force microscopy, cell guidance, optogenetics, photoactivation, active matter, flocking, jamming, tissue mechanics, multicellular systems, epithelium, monolayers

Participants :
- Institute for Bioengineering of Catalonia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet CHAINS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

“Chain expulsions: Syrian refugee returns from Europe and Lebanon (CHAINS)” is an anthropological study of the spatial and temporal dimensions of a legal concept - chain-refoulement. In chain-refoulement, individuals are sequentially forced across multiple countries’ borders without procedural safeguards, exposing them to torture after expulsions and thus violating the non-refoulement principle. Taking this human rights violation as its starting point, CHAINS examines how mobility control practices on flight routes towards the EU come to be entangled in expulsion corridors. While global in nature, chain expulsions are severely under-researched, leaving open questions about actors, consequences and solutions. The dramatic increase of irregular departures of Syrians since Lebanon's economic collapse in 2019 makes the Cyprus-Lebanon-Syria corridor a timely case with relevance for entanglements of mobility control at North/South and South/South borders globally. Research into expulsion corridors breaks new theoretical grounds on mobility control as multiple state and non-state actors interact on emerging scales, imploding territorial assumptions in human rights law. Through mapping and observational interviews and online case studies, the project generates insights into actors and trajectories in expulsion corridors. These empirical insights render visible spatial transformations of state power that result in chain expulsions. Here, CHAINS innovates methods for research impact through the world’s first futures literacy lab with human right practitioners, a participatory research intervention that elicits new pathways for the future.

Mots clés : returns, deportations, state, mobility control, lebanon, syria, pushbacks, cyprus, externalisation, human rights, asylum, borders

Participants :
- Euromed rights - euro-mediterraneanhuman rights network (Danemark) — Partner, associated partner, Autres, subvention : 0.0 €
- École normale supérieure PSL (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 342607.2 €
- Université américaine de Beyrouth (Liban) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet IBERIAN PATRONAGES (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The IBERIAN PATRONAGES project will be focused on the development of an in-depth study of the impact that the creation of the Sacred Congregation ‘De Propaganda Fide’ has had on the regime of the Iberian Patronages. Guided by this goal, this innovative research will decisively contribute to the strengthening of Europe in R&I delivering important contributions to the comprehension of four crucial issues that integrate the investigation: the intimate and structural relationship between religious dimension and the dynamics of domination, control and assimilation of local populations; the resistances and transformations imposed by these populations in response to the directions emitted from Europe; the jurisdictional nature of the policies formulated by the Iberian Monarchies to defend their royal patronages; and the key role played by religion in the configuration of colonial societies.  The research will be anchored in the work developed in historical archives and libraries in Portugal, Spain and Italy, in a permanent exchange of ideas with the supervisor and the host institution (CHAM - Centre for the Humanities), and in an advanced training program designed to enable the researcher to expand her academic networking, provide her insertion in a highly qualified scientific circuit and promote the acquisition and improvement of core competencies and skills for a successful international career plan. A secondment in the Max Planck Institute for Legal History and Legal Theory will improve the scientific knowledge of this research plan. The strong commitment to the Open Science Practices associated with a scientific dissemination plan and plural communication activities were designed to ensure that the research will be able to reach different audiences: the scientific community, the undergraduate and graduate students, teachers and students of the basic education system and the general public.

Mots clés : iberian empires governance jurisdictional conflicts diplomatic relations holy see interethnic relations

Participants :
- Université nouvelle de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet PHOTODOCTOR (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Retinal diseases are the most common reasons of the irreversible blindness worldwide. Common retinal diseases, such as diabetic retinopathy, macular degeneration, retinal vein occlusion and non-infectious uveitis, mostly require intravitreal steroid injections in clinical management. Unfortunately, the intravitreal steroid injections, leads other important ocular problems, such as elevation of intraocular pressure, intravitreal infections and progression of cataracts. Because of these reasons, targeted drug delivery systems are necessity for the medical treatment of retinal diseases. PHOTodynamic Ocular Drug delivery system with Optical Coherence Tomography Oriented microscale Robots (PHOTODOCTOR) project combines three novel technologies to solve this important clinical problem. The first technological advancement for the project is dexamethasone saturated hyaluronic acid (HA) hydrogels with organo-ruthenium complexes, which enables controllable degradation under visible light exposure. With the help of visible light controlled degradation, dexamethasone will be released with the light pulses. Then the hydrogels will be supplemented with super paramagnetic iron oxide nanoparticles (SPIONs) and 3D printed as helical micro-swimmers. Insertion of the SPIONs will help the magnetic actuation of the hydrogel-based microrobots in the intraocular space. Lastly, SPIONs supplemented HA hydrogels will be observed with high resolution optical coherence tomography (OCT) system in the intraocular space to guide them in diseased area of the retina. While HA based structure increases penetration in vitreous and helps to the attachment on the retina, SPIONs will increase the visibility of the microrobots in OCT imaging. By this way, magnetic driven, visible light triggered intraocular drug release system with the OCT guidance will be produced and it could be used for not only intravitreal steroid delivery but also treatment of retinal tumors and other retinal problems.


Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet OSIRIS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Star and planet formation typically occurs in star forming regions more massive than the nearby, low-mass regions that have been the main focus of observational studies of protoplanetary discs. In massive regions, irradiation by neighbouring massive stars can heat this protoplanetary disc of dust and gas, from which planets form. This heating drives thermal winds that extract dust and gas, reducing the mass available for planet formation. In typical star and planet forming environments, these winds are sufficient to drastically change the outcome of planet formation. However, this consideration is currently missing from models. Further, we are yet to find observational evidence of planet formation in the strongly externally irradiated discs that are the most common. These advances are essential steps in understanding the properties of exoplanets, and in uncovering the key processes that govern their formation. During this project, I will make new calculations of the mass-loss rates for irradiated discs as small dust grains are processed into planets. I will then use semi-analytic computational modelling to investigate how the process of planet formation differs in externally irradiated environments compared to non-irradiated environments. I will compare these models to state of the art observations of protoplanetary discs, putting constraints on the physics of disc evolution. Finally, I will run hydrodynamic and radiative transfer calculations to make predictions for observational searches for planets in irradiated environments. These efforts are essential for understanding how planet formation proceeds in typical star formation environments. In this way, I will unveil how the star formation environment sculpts the observed exoplanet population.

Mots clés : planet formation, star forming regions, external photoevaporation, exoplanets

Participants :
- Observatoire de la Côte d'Azur (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
- Université Côte d'Azur (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet SHARE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In an era marked by unprecedented conflicts and climate change, millions of individuals are forced from their homes, often facing vulnerability and trauma. Traumatic displacement is a fundamentally isolating and disconnecting experience with severe health implications. This fellowship project, SHARE, investigates how a sense of shared experience may facilitate reconnection among displaced people, thereby enhancing their well-being and social inclusion, aligning with European and Global goals. SHARE will be the first to clarify how a sense of shared experience contributes to the development of collective social identities (a sense of identification with social groups) and improves the well-being and social inclusion of trauma-affected people. This timely and innovative project expands the Social Identity Model of Traumatic Identity Change and proposes that a sense of shared experience is a crucial social psychological resource that can reduce trauma's adverse effects and support positive change among displaced people. The research will employ a diverse and robust methodology, including systematic reviews and longitudinal studies across multiple countries and varied displaced populations. In addition to providing new databases and scientific articles, SHARE will also develop a new psychological measure and a public health intervention.  The project's findings will significantly advance scientific understanding of the roots and resources in social identity change after trauma. The interdisciplinary and multinational approach will uncover both universal patterns and context-specific factors critical for well-being and social inclusion among displaced people. The fellowship will also offer the applicant a unique opportunity to collaborate with globally recognized experts, enhancing specialist methodological and project management skills. This experience will considerably elevate her professional maturity, positioning her to become an independent and known researcher.

Mots clés : sense of shared experience social identity psychological trauma well being social identity change after trauma

Participants :
- Université du Queensland (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Queen's de Belfast (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 366266.04 €
Projet MAGIMAB (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

How do our mind and brain represent the world? In this project, I propose that cognitive maps and cognitive graphs are two fundamental representational formats supporting our physical (space and time), conceptual (taxonomic and thematic knowledge), and cultural (individualism and collectivism) cognition. To test this hypothesis, I will combine state-of-art neuroimaging techniques with innovative cognitive tasks, including virtual reality, to disentangle cognitive maps and cognitive graphs in both physical and conceptual domains. I will also develop questionnaires and implicit behavioral tasks to assess individual preferences for map and graph representations and test whether this preference relates to the individual difference in cognition and culture. This project has the potential to help trigger a paradigm shift from the traditional map perspective to a dualistic perspective, which focuses on both maps and graphs, thereby deepening our understanding of the organizing principles underlying cognition across domains. This perspective could also inspire the current development of artificial intelligence, and the characterization of individual differences in this project could, in the long run, guide policymaking, design, and education.  This project will be hosted by the Max Planck Institute for Human Cognition and Brain Sciences, which owns the most advanced neuroimaging facilities and a powerful network of servers for data storage and analysis. Prof. Christian Doeller, who is among the top cognitive neuroscientists in spatial memory and knowledge representation, will be the supervisor. This project will also open a new career avenue for the applicant by providing valuable opportunities to develop scientific and technical skills.

Mots clés : cognitive map cognitive graph mental representation neural coding spatial and temporal cognition taxonomic and thematic knowledge individualism and collectivism

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet ProAPP (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

PROteolysis TArgeting Chimera (PROTAC) is a new and attractive therapeutic approach that regulates a target protein by channeling it to the proteasome for degradation (an energy-demanding pathway). Concurrently, proteasomes also play a central role in generating the peptide repertoire for antigen presentation on the Human Leukocyte Antigen-I (HLA-I) molecules. A few years after PROTAC was invented, proteasomes were found to catalyze not only canonical peptide bond hydrolysis, but are also capable of “cut-and-paste” events, i.e. generating spliced peptides, which have been shown to be frequently presented n HLA-I immunopeptidomes. It is unclear how PROTAC-driven proteasome degradation modulates the spliced and non-spliced peptide repertoire derived from a targeted protein. Alterations in peptide variety and quantity produced by proteasome may lead to strong implications on the HLA-I immunopeptidome, and, hence, could result in immune implications. Therefore, using the key oncoprotein KRAS as a PROTAC’s target, this study intends to understand: (i) how PROTAC-driven KRAS degradation affects cellular pathways on a system-wide level; (ii) the impact of PROTAC on KRAS derived peptide repertoire generated by proteasomes; (iii) to what extent PROTAC enhances KRAS derived peptide presentation on HLA-I molecules. Through the combination of a multidisciplinary approach; molecular biology, biochemistry, proteomics, bioinformatics and cellular immunology, this study will provide a better fundamental understanding of the effect of PROTAC-KRAS on the cellular proteome, proteasome-derived peptide repertoire (spliced and non-spliced peptides) and HLA-I immunopeptidome landscape, thus, provide insights into the suitability of PROTAC-KRAS application as a therapeutic approach for anti-cancer therapies. Additionally, this project will deepen our understanding of the role of spliced peptides in the antigen processing and presentation pathway.

Mots clés : antigen processing and presentation, proteasomes, hla i

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet NUC4SIM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Core-collapse supernova (CCSN) explosions mark the end of the life of stars heavier than 10 times the mass of our sun, they play a crucial role for our understanding of the chemical composition of the universe and they are ideal laboratories for effects of neutrino and particle physics. Current research in astrophysics, astronomy and cosmochemistry that requires theoretical CCSN models still, however, relies predominantly on one-dimensional, i.e., spherically symmetric parameterized calculations. This project aims at advancing the state-of-the-art by calculating the composition of CCSN material based on the most recent, first-principles 3D simulations and by providing the results to the community in accordance with FAIR data management principles. The researcher's background in nuclear and neutrino physics will also allow him to study the implications of uniquely multi-dimensional asymmetries in the neutrino emission and the consequences of neutrino flavor conversions, a quantum effect that changes the particles' spectra, for nucleosynthesis, both of which have never been explored and may lead to observational signatures. To achieve the goals, a new and innovative framework for nucleosynthesis calculations at the Max-Planck Institute for Astrophysics in Garching will be developed, based on an open-source reaction network code, which the researcher has contributed to and that he will apply to unique cutting-edge models. The fellow will obtain in-depth knowledge about supernovae and learn state-of-the-art techniques from the world-class team of Prof. Janka and apply them. He will broaden the scope of his work, complemented by a career development plan, training courses and coaching as well as detailed dissemination and public outreach plans to maximize the impact of the project's outcome. The completion of the project will allow the fellow to become a mature and independent scientist, well-recognized in his field of research.

Mots clés : nucleosynthesis, neutrinos, neutrino oscillations, core collapse supernovae, simulations, radioisotopes

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €