Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet GENESYS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Understanding the out-of-equilibrium dynamics of many-body quantum systems is one of the main challenges of the Physics of the 21st century. Despite the complexity of the field, significant steps forward have been achieved thanks to the parallel development of advanced theoretical tools, numerical methods and experimental verifications made with ultracold atoms and ions. In this context, Generalised Hydrodynamics (GHD) represented a fundamental breakthrough which permitted the use of new integrability-based techniques to include previously untreatable experimental effects such as spatial inhomogeneities and temperature gradients. But from this milestone, new questions inevitably arise for which the proposed action stands as a targeted plan of investigation. On the one hand, a known weakness of any hydrodynamic approach is the loss of long-range quantum fluctuations. Although a few attempts to include quantum effects in the formulation of GHD are present, a definitive answer to this problem is still far. On the other hand, the advent of GHD indirectly revived the interest in diffusive models, with the ultimate goal of developing a quantum analogue of the celebrated Macroscopic Fluctuations Theory. In detail, by combining analytical and numerical methods, the proposal aims the fulfilment of three objectives within this landscape, consisting of research and training activities dedicated to i) investigating the quantum corrections of GHD and clarifying the connections among the available theories, aiming at a single description of quantum ballistic transport ii) exploit the developments in quantum ballistic transport to describe currently feasible measures of the correlations of quantum gases out-of-equilibrium iii) connect ballistic to diffusive quantum transport, starting from simple settings. Altogether, these packages represent a fundamental step in the understanding of the emergent hydrodynamic descriptions of non-equilibrium quantum systems.

Mots clés : quantum hydrodynamics, integrable systems, nonequilibrium dynamics of isolated quantum many body systems, transport phenomena

Participants :
- École normale supérieure PSL (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Paris Cité (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Sorbonne Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet BORDERART (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project’s main objective is to build a framework examining how artistic practice can be applied within migration policy contexts. Addressing calls by refugees, asylum seekers and human rights organisations for more humane approaches to policy, this framework will specifically investigate how artworks made in response to the EU migration crisis can raise awareness, build understanding or disrupt usual relationships between refugees, local long-term residents, NGOs and border security personnel. Developed within a comparative study between Greece and Tunisia, the project will reflect the impact of the EU’s current retracting and expanding borders in two key sites on either side of the Mediterranean sea. As the EU enacts ‘buffer zones’ to stem the arrival of asylum seekers on mainland Europe, art practices will be analysed for the ways in which they express and alleviate multiple stresses for those impacted by such policy. Beginning with a review of artistic practices on site in these two locations, the project will map and analyse how art reveals relationships between multiple actors across refugee, resident, NGO and border personnel communities. This review will be contextualised by a wider review of art in global border practices. Interviews with key informants and observations of different practices in Greece and Tunisia will then inform the development of a practice as research methodology, drawing on the ER’s own arts practice to co-create a series of artworks with local actors to test and map possibilities for new and different relationships between those enacting and those impacted by migration policy. This participatory arts practice will iterate through a regular co-evaluation process to a build a framework that reflects the role of art in relation to multi-stakeholder support, partnership building and ethical approaches to inter-personal relationships. The framework and its development will be made available on an interactive website.

Mots clés : borders migration ethnography performance studies relational aesthetics practice as research feminist cultural studies human rights conflict resolution

Participants :
- Université de Graz (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199440.96 €
Projet MeSeCA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The aim of the proposal is the improvement of substantial, technical and software aspects of the digital database of Serbian medieval charters named Diplomatarium Serbicum Digitale (DSD) in cooperation with the Zentrum für Informationsmodellierung (ZIM) of the Graz University. The main objectives are to complete the database material, containing of edited document texts, metadata and images, and to conclude its transformation into a scholarly digital edition according to the current standards of Digital humanities. The DSD project has been established by me and my colleagues from Belgrade in order to fill the void in the research left by the lack of a comprehensive edition of Serbian medieval charters. As its growing digitized material was accessible within the online-database only until mid-2020, when the respective domain expired after the funding by the EU in frames of an international project had been concluded, the future of the undertaking is now depending on the possibilities of its digital transformation and continuing of the research work on editing texts and diplomatic analysis. The best opportunity for achieving those goals would be my longer stay in Graz, continuing the fruitful partnership with the director of the ZIM, professor Georg Vogeler, belonging to the European leading experts in Digital diplomatics, and his colleagues. The cooperation with the ZIM is a necessary step in order to make a digital edition possible and solid performable, especially concerning application of XML standards, publication strategies and long-term archiving. During the stay in Graz I will also firm up my competences in the field of Digital humanities, which are still missing in the Serbian universitary landscape. In that way I would like to give a contribution to the medieval research of my region, but also to present myself as a candidate for a programme in Digital diplomatics, being introduced at the Philosophical faculty in Belgrade.

Mots clés : medieval charters scholarly digital editions southeast european documentary heritage of the middle ages between western and eastern influences multilingual pragmatic literacy digital humanities

Participants :
- Université de Graz (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199440.96 €
Projet UNTANGLED (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Up to 40% of patients with inflammatory bowel disease (IBD) do not respond to standard of care treatment with anti-inflammatory drugs. Unfortunately, the mechanisms driving persistent inflammation are unknown, resulting in a lack of specific therapies and an important burden for patients and society. Enteric neurons are highly specialized cells that sense and respond to nutrients, microbial products and inflammatory signals and densely innervate the gut. Besides regulating gastrointestinal motility, emerging studies indicate that crosstalk between enteric neurons and immune cells regulates inflammation, tissue homeostasis and antimicrobial immunity. However, this has not been investigated in the context of IBD. I hypothesize that enteric neurons become rewired during IBD and acquire an inflammatory signature that amplifies inflammation. Recent technological advancements will allow the investigation of enteric neurons via the use of cutting-edge tools in microfluidic droplet generation, molecular biology and functional genomics. We will leverage the Xavier lab’s expertise in the field of the enteric nervous system at the Broad Institute of MIT and Harvard during the outgoing phase, the expertise of Dr. D’Haens in IBD during the return phase at the Amsterdam University Medical Center and my expertise in pre-clinical IBD models in vitro and in vivo to characterize the role of enteric neurons in IBD for the first time and find potential treatment targets.

Mots clés : ibd, inflammatory bowel disease, crohn s disease, ulcerative colitis, enteric nervous system, enteric neurons, gastroenterology

Participants :
- Broad Institute (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
- Amsterdam University Medical Centers (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 432467.52 €
Projet CECECDW (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The EU's circular economy (CE) initiatives, which encourage material recovery and recycling, would inevitably affect the trajectory towards EU's goal of Net-Zero carbon by influencing material and energy flows. Ideally, the CE of construction and demolition waste (CDW) could yield substantial carbon savings by fulfilling the material demand in the building and infrastructure sector with reduced emission-intensive material production activities. However, the adopted CE measures may also affect carbon emissions through indirect channels. For example, the CE of CDW exhibits an economy-wide impact on several emission-intensive industries, including transportation, power generation, and manufacturing, among many others. Given the complexity of the material and energy flows, a comprehensive and systematic understanding of the carbon emission impacts of CE of CDW is essential for policymakers and enterprises to promote climate neutrality and efficient CE management. In this context, this proposed research aims to assess the carbon emissions (or savings) potential of the EU's CE measures for CDW using an environmentally extended input-output (EEIO) model coupled with updated evaluation parameters from a developed LCA model. The EEIO model, considering the diverse industrial mix in EU member states, can characterize how the CE of CDW affects carbon emissions across different industries and regions. By conducting rigorous empirical analysis and refining the modeling of complex material and energy flows, this research will uncover the gravity of the issue and inform policy frameworks, contributing to the EU's strategic environmental objectives and its path to Net-Zero Carbon.

Mots clés : circular economy construction and demolition waste input output analysis life cycle assessment carbon emissions

Participants :
- Université Heriot-Watt (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet NOMAD (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Epilepsy, characterized by recurrent seizures, is one of the most common neurological diseases globally affecting around 5 per 1000 people in Europe. Yet little is known about the exact mechanism of seizure and its relationship to pathological brain structure. From the clinical perspective, proposing the optimal surgical strategies and predicting the outcomes of surgeries are difficult due to the dynamic nature of epilepsy. The NOMAD project proposes novel network models of seizure propagation based on statistical physics, aiming at understanding the mechanism of the interplay between the brain network changes and seizure propagation, and improving the optimal surgical strategies.  Numerous studies have focused on characterizing the changes in the epileptic brain network via network analysis. However, due to the bias from different measurements and the arbitrariness of choices in diverse types of network analysis, there is considerable controversy in the conclusions. Recently, spreading models built on statistical physics for seizure have been proposed which are promising in predicting epileptic surgical outcomes, yet they are inefficient in surpassing clinical criteria.  Integrating recent advances in statistical physics and network science, NOMAD studies the fundamental roles of inhibitory regulations and plasticity in shaping seizure dynamics, which are neglected in previous studies. I will first study the critical dynamics of seizure on a theoretical model taking into account the role of inhibitory regulations and secondly, a computational framework considering in addition the effect of plasticity via large-scale Monte Carlo simulations. Lastly, I will apply the models to clinical data by predicting the seizure dynamics on brain networks constructed from clinical data and proposing optimal surgical strategies.  The project will provide new insights into understanding the mechanism of epilepsy and potentially new tools to enhance epilepsy surgical outcomes.

Mots clés : complex networks, brain networks, seizure dynamics, epilepsy surgery, brain dynamics, critical phenomena, statistical physics, monte carlo simulations, inhibitory regulations

Participants :
- Université de Grenade (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet FEM4Embryo (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

All living organisms emerge from a single cell, the zygote. In early embryo development of animals, the interplay of cell surface dynamics, polarity proteins and intracellular flows forms distinct polarity domains, which the cell uses to specify the fate of its daughter cells. A classical biological model to learn how animal cells polarise is the 1-mm long C. elegans roundworm. Establishment of cell polarity in the C. elegans zygote is well studied, yet the biophysical mechanisms controlling cell polarity beyond that stage remain largely unexplored. Biophysical experiments and Finite Element (FE) models could together elucidate this matter. However, FE models of multicellular morphogenesis, other than rare, rely on explicit surface descriptions. Explicit methods are not ideal to simulate cell polarity at the multicellular scale, because they can hardly deal simultaneously with 3D foamlike geometries, coupled surface-bulk physics and topology changes. Conversely, FE methods based on implicit surfaces have recently shown convincing potential to bypass this weakness. In this project, I will launch a new implicit-surface FE paradigm to simulate early embryo development and I will apply it to gain new insights on the patterning of C. elegans embryos. To this end, I will pioneer implicit-surface FE methods for coupled surface-bulk dynamics in foamlike geometries. The success of the project is ensured by joining leading expertise in implicit-surface FEs from myself, biophysics of morphogenesis from my supervisor, and patterning in C. elegans embryos from my external collaborator. I will be based at the Center for Interdisciplinary Research in Biology of the CNRS, located at Collège de France; a unique and ideal place to create new synergies between a FE researcher like me, biophysicists and cell biologists, as well as to grow and diversify my scientific and transferrable skills to become one of the few independent leaders in FEs for multicellular morphogenesis in Europe.

Mots clés : finite element immersed boundary unfitted embedded multicellular simulations surface bulk flow couplings c elegans morphogenesis cell polarity polarity proteins mechanobiology actin cortex

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet MechMCA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The interaction between the cell membrane and the underlying actomyosin cortex is vital for various cell functions and survival. This project aims to delve deeper into the intricate mechanics that govern the interaction between the plasma membrane and the cortex, which collectively constitute the cell surface in many cell types. Despite the prevailing view that the cortex completely dominates cell surface mechanics due to its increased tension, this research project aims to challenge that notion. A fundamental aspect influencing cell surface mechanics is the binding strength and dynamics between the membrane and the cortex, facilitated by membrane-cortex junction proteins (MCAs), such as ERM proteins. MCA distribution is influenced by local cortical contractions and protrusions, driven by cortical flows, which in turn may affect membrane tension and MCA dynamics. This project aims to build a comprehensive theoretical framework for cortex-membrane interaction. The framework will include several key physical elements, such as membrane and cortex mechanics, junctional dynamics, interaction with surrounding fluids, and thermal fluctuations, so that it can be applied to multiple cell types and processes. In addition, the physical model will be implemented numerically using phase field methodology to achieve accurate predictions, being open source. These predictions will be used to guide experimental measurements to better understand cell migration in neutrophils through a collaboration. This framework and simulations will help us discover new biomechanical loops essential for the emergence and migration of cell polarity. This research project is expected to have a lasting scientific impact on the field of mechanobiology by proposing a clear and generic biophysical picture of the membrane-cortex interaction and help propel my career path to become a leader in the physical modeling of the cellular mechanics.

Mots clés : cell surface mechanics theoretical biophysics membrane physics actomyosin cortex membrane cortex attachment phase field simulations cell migration mechanobiology

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet QUARTE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The regular rising demand for faster wireless communication (i.e., larger spectral bandwidths) was anomalously boosted recently due to the change on working habits of the Europeans who nowadays more and more work from home or become digital nomads. Optical metasurfaces offer this required high bandwidth combining it with easy fabrication, flexibility, and advanced functionality, rendering them a potential candidate to encounter this demand in wireless optical communications. Despite their large application span (wavefront manipulation, beam steering, perfect absorption), the design of optical metasurfaces is sometimes counter-intuitive and computationally cumbersome, especially when more advanced functionalities are targeted (nonlinear/all-optical control), typically realized by resorting to contemporary material options such as the 2D materials platform. QUARTE aims to present a coherent modal computational framework for the analysis and design of linear and, importantly, nonlinear metasurfaces realized with 2D materials, demonstrating advanced functionalities and all-optical control. The proposed modal framework, based on the concept of quasinormal modes (i.e., the natural modes of leaky and lossy cavities), will be capable of efficiently handling periodic systems (metasurfaces, gratings) consisting of 2D materials and possessing linear and, importantly, nonlinear responses and functionalities. Furthermore, as a modal technique, the proposed approach is capable of revealing the true physics that govern light-matter interaction, especially in the more obscure nonlinear regime, allowing for fast, efficient, and optimal designs with physical intuition and understanding of the involved physics and interactions. The realization of QUARTE research targets will be performed by the Researcher in the Laboratoire Photonique, Numérique et Nanosciences (LP2N), a Joint Research Unit of Centre National de la Researche Scientifique (CNRS).

Mots clés : quasi normal modes, nonlinear photonics, metamaterials, metasurfaces, nonlinear metasurfaces, gratings, 2d materials, periodic structures

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet NanoSep (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Nanoporous solids in interaction with fluids are ubiquitous in our environment. Benefiting from a large specific surface area, nanoporous materials interact strongly with fluids, which makes them an excellent choice for fluid separation applications. But for new applications to emerge, a deeper understanding of the behavior of confined fluid mixtures within multiscale porous materials is required, which is made difficult by the rich behavior of nanoconfined fluids, and the geometric and chemical heterogeneities displayed by most porous materials. The objective of this proposal is to understand how the behaviors of fluid mixtures confined within heterogeneous porous materials impact large-scale fluid demixing properties, and how can this knowledge be used for designing efficient nanoporous filters. To do so, I will set-up a multiscale numerical procedure that extrapolates molecular simulation results to the macroscale through a two-step bottom-up approach. The two fluid mixtures CO2/N2 and CH4/N2 have been chosen for their high environmental and industrial relevance. This bottom-up investigation will allow for the exploration of the equilibrium and transport properties of the confined fluid mixtures for a large range of surface and geometrical properties of the nanoporous material, and address the issue of transport and demixing of fluids in heterogeneous porous materials. This investigation will also help foresee the potential of hybrid porous organosilica for the separation of CO2/N2 and CH4/N2 mixtures.

Mots clés : soft matter, nanofluidics, porous media, biomimetics, hydrodynamics, thermodynamics, diffusion, subcontinuum physics, molecular dynamics

Participants :
- Université Grenoble Alpes (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 70398.72 €