Projet BosomShield (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : SIGNED

Breast cancer (BC) incidence in women produces more than 600,000 deaths each year. The primary cause of death in BC patients is metastasis, whereby cancer cells spread from their primary site of origin and grow in adjacent or distant sites. Distant metastasis produced due to the relapse of the illness is incurable, underscoring the inadequacy of our understanding of its mechanisms. The first step for fighting against disease progression is screening programs for BC focused on image analysis of mammography, MRI and tomosynthesis. Once the tumour has been diagnosed and given the high variability of clinical progressions, another problem arises: classifying the cancer type and determining the proper treatment for specific cancer. Moreover, in BC, the immune response from the tumour microenvironment has played an essential role in tumour evolution. To evaluate the tumour and its microenvironment, one technique garnered a lot of attention in the last years: Whole Slide Imaging (WSI). This technique replaces the use of the microscope for classical diagnosis. Still, it has also been used for developing biomarkers that allow the analysis of tumours and classification of cancer subtypes and the study of the immune tumour microenvironment. The use of WSI has applications for predicting the probability of relapse for distant metastasis. Now, for the first time, BosomShield proposes to join the two disciplines (pathological and radiological imaging) in a software that will analyze these images to classify the cancer subtypes and predict (together with the complete clinical history of the patient) the probability of relapse for distant metastasis. Besides, BosomShield will provide high-level training in BC research to young researchers by offering the necessary transferable skills for thriving careers underpinned using diverse disciplines, digital radiology and pathology, biomedical, AI, privacy and software development.

Mots clés : breast cancer relapse biomarkers radiological imaging pathology imaging

Participants :
- Mediri (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €
- Université de Franche-Comté (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 282693.6 €
- General Electric (United States) (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université du Texas (Etats-Unis) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Azienda sanitaria universitaria friuli centrale (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
- Andalusian Health Service (Espagne) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université de Bourgogne (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Radboud University Medical Centre (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274370.4 €
- Université d'Udine (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 259437.6 €
- Institute of Biocybernetics and Biomedical Engineering (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 226512.0 €
- KTH Institut royal de technologie (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 293709.6 €
- Université Radboud de Nimègue (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University Clinical Centre Maribor (Slovénie) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Généralité de Catalogne (Espagne) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université Rovira i Virgili (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 251971.2 €
- Université de Maribor (Slovénie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 242179.2 €
- University Hospital Sant Joan de Reus (Espagne) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université de sciences appliquées de Darmstadt (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University Teknologi Petronas (Malaisie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Sfera it storitve doo (Slovénie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- N-vision systems and technologies sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 251971.2 €
- UMMON HEALTHTECH (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- O3 enterprise srl (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- CERCA Institution (Espagne) — Partner, beneficiary, Recherche, subvention : 251971.2 €
- Université de Lund (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €