Projet AMR-TB (Horizon 2020, appel à projets 2018)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : SIGNED

Multidrug resistance of Mycobacterium tuberculosis is declared a serious global threat by the World Health Organization. Our project aims at developing a comprehensive model of molecular mechanisms responsible for antimicrobial drug resistance of tuberculosis. Isoniazid is the main drug used for TB treatment, because it interacts with the bacterial catalase that leads to the bacterial death. The library of isoniazid resistant strains (over 100 different strains) will be used as experimental basis for building theoretical and computational models of the molecular processes leading to drug resistance of mutated bacteria. The model will be used for suggesting effective treatment targeting these mechanisms and overcoming the resistance. AMR-TB RISE will be used to utilise the expertise of highly specialised research groups of biologists, clinicians, biochemists, physicists, computer engineers, and mathematicians allowing the researches from these groups to work in multiple laboratories of the Consortium all over the world. Particular attention will be given to training the next generation of young researcher and forming tightly interconnected, long term collaboration devoted to solving the pressing global problem of antimicrobial resistance not only in TB, but in a wide spectrum of diseases.

Mots clés : antimicrobial resistance, multidrug resistance, isoniazide, catalase, molecular dynamics, fitness, landscape, metabolic pathway

Participants :
- King Juan Carlos University (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 41400.0 €
- National Polytechnic School (Équateur) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Spanish National Research Council (Espagne) — Partner, beneficiary, Recherche, subvention : 9200.0 €
- St Petersburg University (Russie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Saint-Petersburg Research Institute of Phthisiopulmonology (Russie) — Partner, organization partner, Recherche, subvention : 0.0 €
- Taras Shevchenko National University of Kyiv (Ukraine) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 96600.0 €
- V. N. Karazin Kharkiv National University (Ukraine) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 36800.0 €
- Kursk State University (Russie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- RIKEN (Japon) — Partner, organization partner, Recherche, subvention : 0.0 €
- Gpu prime ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 27600.0 €
- Freie Universität Berlin (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 9200.0 €
- University of Messina (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 46000.0 €
- University of Surrey (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 13800.0 €
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202400.0 €
- National Academy of Sciences of Ukraine (Ukraine) — Partner, beneficiary, Recherche, subvention : 248400.0 €