Projet CLATHROPROBES (Horizon 2020, appel à projets 2017)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : SIGNED

The CLATHROPROBES project is devoted to the design and development of novel, highly efficient chiroptical, luminescent, IR, NMR and EPR probes for sensing and structural studies of biomolecules based on cage metal complexes (clathrochelates and lacunar complexes of spatial tris-diiminate ligands with encapsulated 3d-metal ion) as molecular reporters. For successful design and synthesis of cage metal complexes (WP1), their complete structural and spectroscopic characterization (WP2), studies of their interactions with biomolecules and reporting properties, and their cytotoxicity and bioactivity in model systems (WP3), the project brings together researchers from four academic institutions and two industrial companies, representing six countries (PL, DE, UA, RO and AU; RU - participation till April 8th, 2022). The participants will contribute to the project with different, highly specific, yet complementary expertise, namely in chemical synthesis of clathrochelate complexes (PBMR and FAU; INEOS RAS participation till April 8th, 2022), identification and structural studies of compounds and materials (PBMR, FAU, UWR, UNIVIE, and SPS; INEOS RAS - participation till April 8th, 2022), characterization of interactions between ligands/clathrochelates/materials and biomolecules by CD, UV-VIS, fluorescence ITC, IR, NMR methodology (UWR, FAU, PBMR, UNIVIE, SPS), and biological studies (FAU). Joint efforts of participants of this multidisciplinary project will provide - the transfer of knowledge between scientists of different research areas, sectors and countries that will enhance level of their professional scientific/technical expertise, -training of young researchers, very important for their further scientific success or industrial career, - enhancement of research activity and network of participating Institutions, - new long-term collaborations between the partners, - increase of academia-industry interactions, so valuable for innovative ideas and discoveries, and pair scientific excellence with social awareness and understanding of current tasks and problems of science.

Mots clés : clathrochelates, cage metal complexes, proteins, albumins, detection, probes, synthesis, spectroscopic techniques, circular dichroism, fluorescence

Participants :
- Russian Academy of Sciences (Russie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Innovation development center abn llc (Ukraine) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 85500.0 €
- Subsidiary company princeton biomolecular research labs (Ukraine) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 346500.0 €
- University of Wrocław (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 148500.0 €
- Sara pharm solutions srl (Roumanie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 27000.0 €
- University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 103500.0 €
- University of Erlangen-Nuremberg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 54000.0 €
- Srl polivalent-95 (Rép. Moldave) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 31500.0 €