Projet eCHO Systems (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

Chinese hamster (CHO) ovary cells are the production host for a +50 billion €/yr biopharmaceuticals market. Current CHO production platforms dates to 1980 and are based primarily on media and process optimisation with little consideration to the optimization of the cellular machinery. Fortunately, with the recent sequencing of the CHO genome, an opportunity has opened to significantly advance the CHO platform. The benefit will be advanced production flexibility and a lower production cost. This ITN graduate training programme - eCHO Systems - will blend conventional molecular, cellular, and synthetic biology with genome scale systems biology training in ‘omics data acquisition, biological network modeling, and genome engineering in three interdisciplinary topics: 1) Acquisition of large scale ‘omics data sets and their incorporation into genome-scale mathematical models 2) Development of genome engineering tools, enabling synthetic biology 3) Application of systems and synthetic biology and genome engineering to improve performance of CHO producers The training projects are supported by 15 industrial participants, which will participate in the research and test the results. ESR training will include intense courses focused on computational systems biology, cell biology, business and entrepreneurship. The three universities bring unique complementary skills in systems and synthetic biology, ‘omics technologies, cytometry, and molecular cell biology which will provide depth and breadth to this training. The eCHO Systems will produce four major outputs: General knowledge to improve the productivity, quality, and efficiency of CHO platform cell lines, new systems models for CHO cells, new CHO cell line chassises generated through synthetic biology approaches, high quality education at the graduate level, and a cadre of interdisciplinary graduates poised to transform biopharmaceutical biotechnology.

Mots clés : systems biology  biopharmaceuticals  industrial biotechnology, synthetic biology

Participants :
- UCB Pharma (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 250560.0 €
- Technical University of Denmark (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1160327.52 €
- Cmc biologics as (Danemark) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Novo Nordisk Foundation (Danemark) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Eli Lilly (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Evercyte (Austria) (Autriche) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Symphogen (Denmark) (Danemark) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Natural Resources and Life Sciences, Vienna (Autriche) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Chorus gmbh (Autriche) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Boehringer Ingelheim (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Fujifilm diosynth biotechnologies uk limited (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Bioneer (Denmark) (Danemark) — Partner, organization partner, Recherche, subvention : 0.0 €
- Dublin City University (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 797023.8 €
- Rentschler biotechnologie gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Icosagen (Estonia) (Estonie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Austrian Centre of Industrial Biotechnology (Austria) (Autriche) — Partner, beneficiary, Recherche, subvention : 1017018.72 €
- Janssen (Netherlands) (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Kent (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 819863.64 €