Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet COMIT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

During brain development, neural progenitor cells generate an enormous diversity of neuronal subtypes in the correct numbers and proportions. Although the transition from progenitor cells to mature neurons is well studied, little is known about how plastic this process is among different progenitor populations and over time. COMIT aims to investigate the temporal dynamics of neural progenitor competence. Using the zebrafish embryonic brainstem –the hindbrain– as a model system and an innovative multicolour lineage tracing system – TEMPO2.0–, I will label and track different generations of specific neural progenitor populations as they progress through differentiation. Leveraging multiple transgenic zebrafish lines, I will monitor the contribution of these progenitors to glutamatergic and GABAergic neuron populations across different temporal windows. Further, I will challenge progenitor competence through heterochronical expression of temporal identity transcription factors, assessing their impact on neuronal subtype specification. Chromatin profiling will be employed to identify the genomic targets of re-specification factors, shedding light on the molecular mechanisms that regulate progenitor plasticity.  This integrated approach, combining cutting-edge biocomputing, imaging, genetic, and molecular techniques, will provide key insights into the heterogeneity of neural progenitor competence and the mechanisms that control the generation of neuronal diversity. Ultimately, the findings from this research could pave the way for new cell therapy strategies targeting neurodevelopmental and neurodegenerative diseases.

Mots clés : zebrafish, plasticity, neural progenitor, cell fate, temporal patterning

Participants :
- Université Pompeu Fabra (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €
Projet VIA-TARIQ (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The ‘VIA-TARIQ’ is an interdisciplinary project that aims to explore key topic among the archaeologists and historians of the Near East: what is the level of persistency/discontinuity of the Roman road system in the longue durée and what influences it had on the social and economic developments in the Medieval and modern period. The project will approach these issues through analysis of large aggregated archaeological datasets and advanced spatial modelling methods, enabled through training in these methods at the host institution. The project will significantly add to our understanding of the centuries-long change and development of the road and transport networks in the Levant. It will illuminate the long-term effects of the Roman road infrastructure on the economic developments in the Medieval and Ottoman periods. The training and research offered by the project will position the applicant as an expert in archaeological computational modelling for the study of the past and will enable him to influence paradigms and inform debates in the history and archaeology of the Near East.

Mots clés : historical roads, persistence, transport networks, spatial analysis, gis

Participants :
- Université autonome de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet HESS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Welfare states, in general, aim to mitigate social inequalities; however, in differentiating rights among social groups, their institutional architecture may further deepen pre-existing disparities. In the field of healthcare, this phenomenon has been coined as healthcare system segmentation; that is, the co-existence of different and independent healthcare arrangements, each of them targeting distinct social groups. Particularly prevalent in the Global South, healthcare system segmentation is largely neglected by the scholarship, and the few existing studies focus on contemporary manifestations of the phenomenon, while its origin, evolution, and reasons for existence remain unexplored. To fill this gap, the project (HESS) aims at investigating the emergence and development of healthcare system segmentation in twelve South American countries from a comparative and historical perspective. First, it will describe and analyse healthcare system segmentation’s (a) emergence and expansion, (b) inclusion and exclusion of social groups, (c) cross-country variation, and (d) temporal distribution. Second, it will explain whether the extent of segmentation observed within and across countries can be explained by economic, political, social, and/or policy-field specific factors. To do so, HESS will construct a novel dataset on the historical development of healthcare system segmentation in the region. This data will be made publicly available on a newly developed website, fostering further research in the domain. Adopting document analysis, descriptive statistics, and qualitative comparative analysis (QCA), the project will enrich theoretical and empirical understandings of welfare states and healthcare systems of the Global South, as well as provide guidance for policy-making, especially in light of the increasing global call for Universal Health Coverage put forth by the Sustainable Development Goals and most recently by the COVID-19 pandemic.


Participants :
- Université autonome de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet GECKO (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The prevalence of chronic kidney disease in Europe varies from 3.3–17.3% and has risen during the last decades. In the world, 9.7 million people need kidney replacement therapy, but only 2.6 million will receive it. These numbers are expected to double within the next 10 years, increasing the pressure to find alternative solutions. Recent scientific developments to generate kidney organoids in vitro have opened the possibility for a regenerative medicine–based approach that would provide a functional substitute to the failing kidney. These kidney organoids can recapitulate renal structures as well as the cellular complexity of human kidney, and may restore glomerular filtration upon transplantation. In this project, we make use of human induced pluripotent stem cells that can be differentiated with a cocktail of biomolecules and aggregated to form of kidney organoids that are cultured at the air–liquid interface. This protocol leads to the formation of complex renal structures including glomeruli and tubules. While kidney organoids show great therapeutic potential, they also present several drawbacks, one of which is the appearance of off-target cell populations, such as neurons, myocytes and chondrocytes within the organoid. Preventing the appearance of these off-target cells will greatly improve the quality of the organoids. Preventing cartilage formation is most desirable because cartilage completely disrupts the organoids and renders them dysfunctional and unsuitable for in vivo use.  The reasons for the consistent observation of chondrocytes during organoid growth and transplantation are not yet understood. The objective of this work is to understand the molecular mechanisms of cartilage formation in kidney organoids and reduce it using a small molecule strategy.

Mots clés : kidney organoids, cartilage, regenerative medicine, small molecule strategy

Participants :
- Université de Maastricht (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203464.32 €
Projet OH-GENDER (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In Europe, 53.5% of adolescents consume alcohol in excess, but what has attracted attention is the increase in consumption among girls. These used to drink less than boys, but now their consumption is equal and on some contexts larger than boys. How this happens in Europe, where it can be considered a trendsetter, should be a global concern. Thus, understanding the reasons for this behavior change is essential to develop prevention program strategies that are effective in young people. Existing programs are not successful, they do not focus on specific gender situations and also on the mechanisms involved in this process. In addition, studies to date do not have a quantitative assessment, as there are no instruments to unravel the reasons for alcohol consumption from the perspective of gender difference. Current studies have only a qualitative assessment, it is impossible to compare groups of people and populations, making a global view of this field unfeasible.Thus, the proposal will unravel the determinants of alcohol consumption in adolescents and young adults from a gender perspective. This will be a paradigm shift in the knowledge of alcohol consumption. OH-GENDER is highly original and innovative as it provides a new instrument for quantitative assessment and will deliver a new model of consumption of alcohol determinants by an advanced technique of statistical analysis (Structural Equation Model) advancing the field of gender disparity. a tool to identify the different needs between girls and boys, disclosing the determinants of alcohol consumption from a gender perspective will be an advance in the state of the art, filling this unexplored knowledge gap. The proposal will advance in the field of alcohol consumption prevention and has the potential to be an ongoing study after PF.

Mots clés : alcohol related disorders

Participants :
- Université de Valence (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet TolGreen (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Viral diseases cause severe damage to cultivated plants, resulting in global crop losses. In the wild, however, plants are typically free of viral disease symptoms despite recurrent infection. Naturally tolerant plants have a significant viral load, but their growth, development and reproduction are only minimally affected. The aim of the TolGreen project is to identify viral and host determinants of tolerance by using Arabidopsis-infecting RNA viruses such as Tobacco mosaic virus (TMV) and the related Oilseed rape mosaic virus (ORMV) as models. Certain natural accessions of A. thaliana (Col-0) are tolerant to TMV whereas other ecotypes (Sha) show disease. By contrast, Col-0 plants infected with ORMV are initially symptomatic but develop tolerance in the new leaves. The host laboratory demonstrated that this latter tolerance phenotype depends on genes required for the production of primary and secondary siRNAs and also correlates with the loss of the activity of the viral RNA silencing suppressor (VSR). The tobamoviral VSR proteins inhibit antiviral RNA silencing by sequestration of small interfering RNAs (siRNAs), which inhibits the assembly of the antiviral RNA-induced silencing complex (RISC). Therefore, tolerance may occur when the VSR siRNA binding activity is saturated by host- or virus-derived siRNAs. Using the latest tools of molecular genetics and proteomics, TolGreen will determine Arabidopsis genes, viral and host-derived siRNAs as well as VSR-interacting proteins that control VSR activity and are involved in tolerance. Understanding the molecular mechanism of tolerance will provide important tools for the breeding of resilient, virus-tolerant crops for a more sustainable agriculture.

Mots clés : plant virus interactions, tolerance, recovery, rna silencing, viral suppressor of rna silencing, small rnas, arabidopsis

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet ON THE SPOT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This two-years project proposes the first material, social, and gender history of eighteenth-century naturalists’ travel journals. The project is particularly timely now that mobility is at the heart of social, cultural, intellectual, gender history and the history of science, and that travel narratives have been recognised as important sources for historical analysis. However, so far only a few studies have been devoted to the travel journal, that very object in which naturalists used to record their observations while travelling. ON THE SPOT will fill this gap, by focusing on the various and still ill-explored archival materials assembled by two famous married collaborators, Antoine Laurent Lavoisier (1743-1794) and Marie-Anne Paulze-Lavoisier (1758-1836) while travelling in the French provinces in the second half of the eighteenth century. Through an interdisciplinary approach, the project will unfold the variety of social, intellectual, and cultural values and emotions operating in the production and use of the travel journal. The project’s broader aim is to provide a theotherical and methodological framework that will allow to understand naturalists’ travel practices as collective and gendered endeavours. The action will be undertaken under the supervision of Prof. Mónica Bolufer at the University of Valencia (UVEG). It will comprise a transversal training in gender history and the acquisition of transferable skills, as well as a targeted program of dissemination and communication activities. Prof. Bolufer’s ERC-funded research project “Circulating Gender in the Global Enlightenment: Ideas, Networks, Agencies (CIRGEN)”, which focuses on transnational approaches to gender, identities, and cultural mediations in Enlightenment societies and cultures, is highly complementary to my experience as an historian of eighteenth-century science, making UVEG the perfect locus for my project.

Mots clés : gender and science material history of science paper technologies history of travel

Participants :
- Université de Valence (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet AQUPLAST (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Plastic pollution is an issue of environmental concern intensively discussed in the scientific literature and public media in recent years. Particularly, microplastics (MPs) and/or nanoplastics (NPs) are a kind of pollutants potentially hazardous for ecosystems and human health that can be ingested by aquatic fauna. In this context, the presence of MPs and a lesser extent of NPs have been reported in the environment and biota. However, the detection of these pollutants generally it happens through techniques that allow its identification and characterization but have not enough sensitivity and/or accuracy to provide quantitative reliable results. Therefore, this project will focus on developing an accurate and reliable analytical procedure by liquid chromatography coupled to high resolution mass spectrometry for monitoring the occurrence and spatial-temporal distribution of MPs and NPs in environmental compartments and the further risk assessment in environmental and human health. This project shows an interdisciplinary nature that involves environmental, analytical chemistry and social sciences research field. This latter, considering the anthropogenic approach of this action. In addition, this proposal includes a two-way transfer of knowledge between the researcher and the host institution, as well as the training of the researcher in new advanced techniques both at the host as partner institution. The results of this project will allow to correlate the presence of MPs and NPs with anthropogenic and seasonal factors through accurate analytical methodologies. Moreover, it will allow a better understanding of risks of MPs and NPs pollution for environmental and human health, providing data that could be used by policymakers. To emphasize, this project is aligned with the European Union strategy of developing accurate analytical methods for quantify MPs and NPs in environmental matrices and biota in order to perform appropriate risk assessment.

Mots clés : micro nanoplastics, analytical methodologhy development, liquid chromatography coupled to high resolution mass spectrometry, spatial temporal monitoring, environmental and human health risk assessment

Participants :
- CERCA Institution (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Valence (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet EFT4ward (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

After more than a decade of data-taking, no direct evidence of new particles has been found at the LHC, suggesting that new physics (NP) might be heavier than the energies currently probed. Heavy particles can alter interactions among known particles, causing subtle deviations from the Standard Model (SM) predictions. The Standard Model Effective Field Theory (SMEFT) is a robust framework that allows for a model-independent parametrisation of new interactions, providing us with the tools needed for a successful indirect discovery program. In particular, the peculiar structure of the theory dictates correlations between different observables, motivating global analyses. In this proposal, I develop a strategy to advance global SMEFT interpretations in three key directions. Firstly, I will expand the comprehensiveness of the dataset by including low-energy observables in current global fit methodologies. To accomplish this, renormalization group equations mixing effects must be included in theoretical predictions, as they prescribe how different energy regimes are connected. Secondly, the research project aims to advance the design of optimal observables for global fits by using machine learning techniques, with the goal of maximising sensitivity to NP. Lastly, the ultimate objective of indirect searches is the identification of heavy new particles responsible for the modified interactions; the SMEFT is simply an intermediate step in this endeavour. I will provide the particle physics community with an open-source software that will interface with the output of global SMEFT fits and indicate which heavy particles are disfavoured by the data and which are still viable. The combination of my expertise in SMEFT analyses and collider phenomenology, along with the host institute's proficiency in advanced statistical methods, flavour physics, and UV matching, provides an ideal setting to successfully execute the proposed tasks and significantly advance indirect searches.

Mots clés : collider phenomenology, effective field theory, global fit, machine learning

Participants :
- Université de Valence (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet MIMEPOC (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Particulate organic carbon generated by primary production in surface waters is exported into the ocean’s interior through the biological pump, contributing to the regulation of atmospheric carbon dioxide and partial sequestration of ocean carbon. Microbial transformation mechanisms on sinking aggregates directly impact the quantity and quality of organic matter reaching the deep sea. Due to their importance in biogeochemical cycles, sinking particles and their microbial components have received increasing attention in the past few years. However, microbial interactions and mechanisms involved in particle formation and degradation remain largely unexplored. The overarching goal of the current project is to explore for the first time the specific functions of particle-associated prokaryotes in determining the fate of sinking particulate organic matter (POM). First aim is to investigate in situ the RNA-based functional and genomic characteristics of sinking particle-attached microbes over time at different depths, using metatranscriptomics and metagenomics analyses. We also aim to elucidate the protein-based functional profiles of microbial communities on sinking particles and uncover linkages between microbial enzymes involved in the degradation of POM, using a comparative metaproetomics and metagenomics approach. Additionally, we aim to examine the carbon uptake, metabolic activity and colonization patterns of sinking-particle-attached microbes, using stable isotope probing coupled with amino acid tagging and liquid chromatography mass spectrometry. It is anticipated that the insights provided into microbially mediated processes regulating POM transformation will set the basis for better understanding the oceanic carbon cycle, and further improve predictions on future ocean biogeochemical cycles and climate change.

Mots clés : environmental microbiology microbial oceanography biofilms marine snow sinking particles biological carbon pump particulate organic carbon metatranscriptomics metagenomics

Participants :
- Université de Vienne (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 190401.01 €
Projet ZUMBBA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Human population in cities is expected to increase globally by 1 billion before the end of the current decade leading to a 1.2-1.8 million km2 expansion of urban areas. The planning of natural environments in cities is essential to provide a broad array of ecosystem services like mitigation of extreme weather events, clean air, and recreational opportunities. However, these benefits need to be considered together with the possible costs that may arise due to increased possibilities of human-wildlife conflicts such as those caused by the spread of zoonotic diseases. Tick-borne diseases such as Lyme disease, Mediterranean spotted fever, Q fever, and Crimean-Congo hemorrhagic fever are major health problems forecasted to become increasingly important in Europe in the next future and require close monitoring. Birds are an effective and fast means of transport for thicks and can facilitate the spread of diseases. Most available researches sample ticks from birds and other wildlife to asses the presence absence of pathologies in natural habitats, or use spatial modeling to forecast the distribution of diseases based on bioclimatic variables. However, studies that directly trace the role of birds movements in urban areas to define gradients of risks for the local population are lacking. Additionally, it remains controversial whether higher biodiversity, by strengthening ecosystem stability and creating a dilution effect, decreases the risk of zoonosis spreading, or whether higher biodiversity may actually enhance and propel the diffusion of pathogens. The current proposal aims at testing 1) if emerging tick borne diseases are present in Spanish cities of different sizes (Barcelona, Valencia, Toledo), 2) if the movement of Parus major, a non migratory species of bird can be used to trace the distribution and spread of of tick born diseases within urban areas, 3) if the distribution and occurrence of tick born diseases covary with the levels of local biodiversity.

Mots clés : tick born diseases, movement ecology, urban ecology, spatial modeling, birds

Participants :
- Université de Valence (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €