Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet QUNS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) are supremely important techniques with widespread applications in chemistry, physics and medicine. NMR methodology has until recently been limited by the time constant T1 for the decay of nuclear spin magnetization back to thermal equilibrium. Long-lived nuclear singlet states (LLS) have been shown to overcome this limit with a decay constant TLLS that may be two orders of magnitude longer than T1. However, so far mostly ideal systems have been studied in the LLS context, involving simple solvents and oxygen and other paramagnetic molecules removed. This is far from the conditions in many potential applications of MRI and/or materials research, and it is not clear how LLS performs in environments such as complex fluids or biological matter. To overcome this limitation, the proposed project is to develop state-of-the-art quantum-statistical simulation methodology toolbox to model TLLS in complex fluids (lipid/water phases). The project builds on the experience of the research fellow in LLS and computational engineering combined with quantum-chemical, molecular simulation, and experimental expertise of the host institution. Methodology for the essential but challenging quadrupole and paramagnetic spin relaxation enhancement will be developed for LLS. Machine learning techniques will overcome the excessive computational burden of very many quantum-chemical calculations needed in conventional computational relaxation studies.The simulated TLLS will provide a general understanding of the applicability of LLS at the microscopic level, for colloidal systems. The theoretical understanding will guide the development of LLS in materials research and MRI. Machine learning development will feed into the quantum chemistry studies of NMR and other molecular properties in complex systems, as well as computational engineering.

Mots clés : quantum chemistry, nuclear magnetic resonance, stochastic liouville equation, machine learning, surrogate model, colloid

Participants :
- University of Oulu (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 179325.6 €
Projet EUREKA (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The aim of the project is to provide the interdisciplinary training to young talented researcher Dr. Evgeny Apartsin, specialist in biomaterials science and nucleic acid therapy, to become highly qualified world class researcher. The Applicant proposes an interdisciplinary approach for the design of multifunctional phosphorous dendritic systems for the delivery of therapeutic nucleic acids in vitro and in vivo. During the project implementation, novel stimuli-sensitive supramolecular constructions based on phosphorous dendrimers and dendrons will be created to be used as carriers for chemodrugs and nucleic acids. The synthetic part of work will be done in the Host organization, which is world leading institution in the dendrimer science and applications. The physics-chemical and biological parts will be done in collaboration with the Partner organization together with recognized specialists in biophysics, molecular and cell biology. At the last stage of the project, the synthesis of best candidate therapeutic constructions will be transferred to the industry. The Applicant will receive numerous scientific trainings from the experts in macromolecules and medicinal chemistry, molecular biology and industrial technology as well as additional trainings on project management and funding, public dissemination of results, presenting and teaching. The trainings and the implementation of this project (knowledge, skills, papers, patents, etc.) will help the Applicant to be efficiently integrated into the European and international science at highest level.

Mots clés : dendrimers, dendrons, nucleic acid therapeutics, targeted drug delivery, chemodrugs, micelles, liposomes, encapsulation

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 196707.84 €
Projet LDTSing (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

The aim of the project is two-fold. One goal is to employ techniques from smooth 4-dimensional topology in the study of deformations of isolated surface singularities. More specifically the project aims at advancing in the study of smoothings of rational surface singularities by means of gauge-theoretic invariants as well as lattice-theoretic combinatorial techniques. A conjecture of Kollar regarding a class of rational surface singularities with a unique smoothing will be considered. The conjecture has natural symplectic and topological counterparts. The plan consists in proving the topological version and investigating the extent to which this version of the problem can lead to advancements in the original conjecture. Another primary goal is to investigate properties of the 3-dimensional rational homology sphere group, such as n-divisibility and torsion, via constructions involving rational cuspidal curves in possibly singular homology planes. In this context a first specific goal is producing examples of 3-manifolds which are either Seifert fibered spaces or obtained via Dehn surgery on an algebraic knots which are 2-divisible in the rational homology sphere group. In a similar setting it will be investigated the extent to which rational homology balls bounded by integral surgeries on torus knots can be realized algebraically.

Mots clés : homology cobordisms of 3 manifolds, rational surfaces singularities, deformations, rational cuspidal curves

Participants :
- Université de Lille (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €
Projet MAREITA (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of this Fellowship is to develop a strong academic profile by improving my publications record and working in highly interdisciplinary research environments, so as to establish myself as a leading voice in the research on the interconnections between literary and electronic culture and to secure a permanent academic position at a European university. I will carry out my research at the School of Languages, Literature and Cultural Studies at Trinity College Dublin, under the supervision of Dr Clodagh Brook. My project investigates the intermedial dialogue between Italian literature, from the mid-1950s up to the present day, and electronic media. I will combine interdisciplinary critical analyses of literary texts with Social Network Analysis and a quantitative approach to the phenomenon of remediation in literature. The main outputs will be a monograph dedicated to the subject and a website hosting the SNA graphs resulting from my work. Two main research training components will allow me to achieve my goals: I will gain expertise in interdisciplinary research applied to literature through Dr Brook’s mentorship and thanks to the collaboration with the AHRC-funded research project ‘Interdisciplinary Italy 1900-2020: Interart/Intermedia’, for which Dr Brook is the Primary International Investigator. The opportunity to be a part of this research team—the only one currently working on the topic—will allow me to hone my research skills and develop my professional network. Secondly, I will improve my coding skills and learn how to create and analyse network graphs using the necessary software by collaborating with the Centre for Digital Humanities at the Trinity Long Room Hub Arts & Humanities Research Institute. Not only has the Centre an international reputation and vast expertise, but its ongoing project K-PLEX (Horizon 2020) on Humanities and big data shares some of my research aims and methodology, thus opening up possibilities for a fertile collaboration.

Mots clés : italian literature, electronic media, remediation, interdisciplinarity, intermediality, social network analysis, digital humanities, quantitative analysis

Participants :
- Trinity College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet Constr-HaVi (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of this Fellowship is to develop the professional prowess, advanced training, interdisciplinary skills, high-impact dissemination, and practical experience commensurate with a leading independent researcher in the EU. The aim of the project is to investigate the building and engineering techniques utilized in constructing Hadrian’s Villa. For the first time, I will apply a new research approach to a comprehensive study of the villa that concentrates not only on architectural design and form but also on building materials, construction techniques and engineering. The main objective is to create a synthesis combining analysis of the buildings with a critical study of the bibliography that will result in a comprehensive corpus of the building solutions found in the different structures across the entire site. I will be based in the Department of Classics in Trinity College Dublin (TCD), working under the supervision of Professor Hazel Dodge. Research training will be implemented through an interdisciplinary project investigating the ancient architectural process of construction. I will access expertise, advanced training and mentoring in the History of architecture. No Irish university, but Professor Dodge, has yet established a dedicated History of the roman architecture. In TCD I will be given the opportunity to embed new knowledge in the design of interdisciplinary curricula for graduate students. Under the guidance of international experts, I will acquire an invaluable skill-set bridging humanities, science and technology with implications for contemporary conservation of cultural heritage. The resources of the host departments will facilitate development of an interdisciplinary and international academic network as well as career-mentoring. The Fellowship will establish me firmly at the centre of interdisciplinary research in the histories of building science.

Mots clés : archaeology of construction, hadrian s villa, ancient architecture, organization and use of space, building and engineering techniques of construction, experimentation, innovations, this proposal

Participants :
- Trinity College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet GreenX4Drug (Horizon 2020, appel à projets 2018)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : SIGNED

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to develop and exemplify the use of new catalysts and new green reactions to manufacture important halogenated compounds that could be used in drug discovery and drug production. In order to achieve this objective the proposal brings together 3 partners with complementary skills: University of Naples (UNINA): expertise in medicinal chemistry and drug discovery. KelAda Pharmachem: expertise in green chemistry, chemical batch process development and scale-up. UCO: expertise in process engineering of continuous flow processes. We have broken this proposal into the following separate technical Work Packages: WP1: Preparation of new catalysts for efficient desymmetrization [WP Leader: UNINA]. WP2: Development of enantiospecific halogenation including Fluorination. [WP Leader: Kelada Pharmachem]. WP3 Drug Candidate, library creation & in vitro testing. [WP Leader: Kelada Pharmachem] WP4 Development of flow variant and scale-up.[WP Leader: UCO} The above WP's will be undertaken via a series of interlinked secondment of researchers between the consortium partners and will be complemented by a series of training and other initiatives to facilitate interdisciplinary and inter-sectoral knowledge sharing and exchange.

Mots clés : organocatalysis, halogenation, green chemistry, continuous flow

Participants :
- University of Córdoba (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 276000.0 €
- University of Naples Federico II (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 110400.0 €
- Kelada Pharmachem (Ireland) (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 220800.0 €
Projet GREAT (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

The aim of this project is to consider X a smooth projective algebraic curve and a representation ρ of π1(X) into a semisimple Lie group G, and study deformations of ρ when X deforms into a singular curve. This question will open a brand new direction in the theory of representations of fundamental groups and G-Higgs bundles. The main tool to approach the problem will be non- abelian Hodge theory to transform this topological question into the geometric one. Then we use recent new developments in the classification of representations together with new algebraic objects which recently appear in non-abelian Hodge theory to study this question. It will take us to the study the deformations of G-Higgs bundles together with deformations of harmonic bundles over X when X is a curve and varies. This project will allow the researcher to broaden her area of expertise as well as to develop new directions in her research lines. She will complement her knowledge in differential geometry in one of the most prestigious Universities and under the guidance of one of the worldwide leaders in this field.

Mots clés : representations of the fundamental group, parabolic higgs bundles, non abelian hodge theory

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 91727.4 €
Projet RoboCat (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The aim of this project is to design, synthesize and investigate the operation of synthetic molecular machines capable of performing sophisticated tasks in chemical synthesis. The molecular machines are inspired by biological systems, where substrates are shuttled between different enzymatic sites, undergoing chemical transformations at each step. Control of substrate position allows for reactions to occur in a specific sequence, with the molecular machine dictating the selectivity of each successive chemical reaction. The project both seeks to optimize the structure of the molecular machines for use as a synthetic platform and demonstrate their usefulness for synthesis and catalysis in model reactions. The successful demonstration of this concept would mark the beginning of a fundamentally new approach for the construction of molecules.

Mots clés : molecular machines, host guest chemistry, molecular devices

Participants :
- University of Manchester (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet Peripheality (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of this project is to determine the functional significance of the peripheral visual field for human perception and its interaction with the motor system. While it is well established that central vision serves to resolve the fine details of the visual world and the objects in it, the reduced spatial resolution in the peripheral part of our visual field suggests that peripheral vision may have a very different role. In this project we will use an innovative combination of Virtual Reality (VR) with physiological recordings and computational modelling to examine the hypothesis that the peripheral visual field acts as a change detection mechanism. Specifically, under conditions resembling those encountered in everyday life, we will explore the presence of serial dependency (SD) effects, i.e., the integration of past with current information during visual processing. These experiments will provide the first evidence that SD strategies are employed during everyday activities in complex environments in daily life, while the nature of the SD effects (i.e. positive vs. negative) will allow us to deduce differences in the functions of the central and peripheral visual system. Importantly, the experiments will also allow us to assess whether peripheral vision is involved in a multisensory and hypersensitive "alarm system", an idea that has recently been proposed in the literature. Finally, by employing computational modelling methods we will attempt to provide a comprehensive theoretical account for experimental findings. Overall, this interdisciplinary project is expected to provide important insight into the basic mechanisms of human vision that are responsible for maintaining the equilibrium between visual stability and change detection over the whole visual field.

Mots clés : vision, perception, peripheral visual field, change detection, serial dependency effects, virtual reality

Participants :
- University of Cyprus (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 151648.8 €
Projet RELEVANT REALISM (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of this project is to develop a fully functional new concept of realism which intrinsically combines theories of truth with theories of action. This new theory will be measured against other contemporary approaches and adapted to current political problems to validate it and to investigate its practical applications. The problems underpinning the urgent need of developing a new concept of realism are, namely, the rise of authoritarianism and the apparent ineffectiveness of current truth-concepts and communicative strategies in countering totalitarian, authoritarian, and simplistic-populist discourses. The innovative, nostalgia-free concept of realism titled “relevant realism” will provide new ways to frame current political problems and new tools for political communication while avoiding both the current realist backlash and the postmodern relativist trap. The project will engage in a detailed analytic assessment of concepts of realism and a comparative analysis and fusion of positions in Neopragmatism, Poststructuralism, and adjacent theories. Providing a realist approach without losing sight of postmodern and poststructuralist contributions to disentangle and unveil the power-mechanisms involved in every truth-claim is of utmost interest for a culturally diversified space like Europe where constant complexifications of cultures and ways of living have to be faced and are to be preserved as a value. The project will be carried out at the University of Bologna and at the University of Oslo during a secondment period. Research outcomes will be disseminated via conferences, workshops, and scientific publications, exploited for broad policy impacts, and communicated to the larger public via multiple outreach activities. With its cross-cultural, interdisciplinary approach and via mutual theoretic reinforcement the project offers the perfect balance between research innovation, individual career development, stronger networks, and mobility between systems.

Mots clés : rorty, postmodernism, poststructuralism

Participants :
- University of Bologna (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183473.28 €
Projet PEERS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

The aim of this project is to develop a theoretical and empirical framework to simultaneously study network formation and peer effects in education. The problem is important from a methodological perspective, as there do not exist general purpose estimatable models of social dynamics in Economics which treat the network formation process as endogenous and simultaneously contemplate network effects on behaviour and its feedback on the network formation process. The possibility of understanding the formation of social networks in terms of the characteristics of the agents forming links is severely limited in most applications by the presence of peer effects that alter these characteristics. Conversely one of the main difficulties in measuring peer effects in any context is that peer groups are endogenous. This project will have two main components (1) a theoretical component and (2) an empirical/experimental component. The theoretical component aims to construct and study in detail the properties of some models of peer effects treating network formation endogenously. In the empirical/experimental component I will estimate and test the models by (a) Relying on two datasets, one of which already exists and one of which is under construction, and which I am currently using on two related projects and (b) Building a detailed longitudinal dataset including information on social network structure and various kinds of behaviours and attitudes using surveys and economic experiments .


Participants :
- Fundació markets, organizations and votes in economics (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €
Projet CUISINE (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of this project is to develop an innovative methodology for the study of culinary practices (cuisine) in past societies integrating the morpho-typological analysis of cooking pots, the analysis of their lipid content and the analysis of microbotanical remains. By analysing a society's diet and cuisine we can explore, for instance, cultural development expressed through growing complexity in parallel with the development of more complex social and technological structures. This project will explore culinary practices in past societies through the integrated analysis of phytoliths, starch grains and lipids from cooking pottery. In order to interpret the archaeological record, extensive plant reference collections and several experiments will be developed as part of the project. At the same time, the methods developed during the experimentation phase will be tested and validated on two archaeological case studies in the Aegean, an area that has historically been (and still is) a crossroad for people and foodstuffs: the Neolithic site of Stavroupoli (Greek Macedonia, ca. 5600-5000 cal. BC) and the Bronze Age site of Knossos-Gypsades (Minoan Crete, ca. 3650-1100 cal. BC). The development of these integrated analyses on Neolithic and Bronze Age settlements will allow for the study of the emergence of new social practices and cultural identities linked to the origins of food production and the development of complex, urban societies.

Mots clés : archaeology, microbotanical remains, lipid analysis, pottery, cuisine

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €