Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MITOCHONTACTS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Organelles offer separate reaction chambers within a eukaryotic cell, thus expanding cellular metabolic capacity but necessitating mechanisms for interorganellar communication. Mitochondria are key players in cellular metabolism and their dysfunction leads to devastating conditions. Intriguingly, they are largely excluded from vesicular trafficking, creating a mystery of how they can fulfill their functions despite being cut off from these important routes of intracellular crosstalk. Membrane contact sites (CS) are starting to be appreciated as a further, vesicle independent, means of communication between organelles. CS are domains where membranes of distinct organelles are tethered by proteinaceous machineries. Factors tethering mitochondria to the endoplasmic reticulum, the vacuole/lysosome and the plasma membrane are known. Electron microscopy studies suggest existence of several additional mitochondrial CS that are currently unknown at a molecular level. Discovery of the principle of interorganellar crosstalk via CS finally offers a solution to the paradox of mitochondria as metabolic hubs being largely excluded from vesicular traffic. In order to understand how mitochondria are integrated into cellular physiology, we need to know the molecular nature of the entire repertoire of CS, their specific biological roles and their regulation in response to metabolic changes. I will utilize a systematic approach to map the complete spectrum of CS between mitochondria and any other cellular organelle in the most experimentally accessible eukaryotic model organism, the yeast Saccharomyces cerevisiae. My approach relies on creation of a molecular sensor for contact sites and its utilization in high content screens to uncover the tethers, regulators and function of mitochondrial CS. Ultimately, my goal is to build a model describing the integration of mitochondrial behavior into cellular physiology via CS-based mechanisms on a holistic level.

Mots clés : mitochondria, membrane contact sites, saccharomyces cerevisiae, systematic, high content screen

Participants :
- Weizmann Institute of Science (Israël) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 182509.2 €
Projet Supra spin-selection (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Organic electronics which exploits charges (electrons or holes) of π-conjugated molecules/polymers has garnered attention in the past decade due to the low cost, ease of processability and most importantly the flexibility to tune the electronic properties through chemical synthesis. In addition to charge, spin as a quantum number provides exciting opportunities to store data in memory devices, in spin filters and spin-based organic light-emitting diodes. Typically in spintronic devices, switching of the magnetism of one of the ferromagnetic layers is required to attain spin-selectivity. Recent works have demonstrated high (>60%) spin-selectivity in organized chiral double-stranded deoxyribonucleic acid (DNA) without the use of magnetic materials. The high spin-selectivity was attributed to the creation of chiral field in which the electron-transport takes place through DNAs. It is to be noted that the organization of DNA strands is pivotal in achieving high spin-selectivity. Presently, the main focus is on bio-inspired molecules such as peptides and DNAs. Due to the versatility and processability of organic semiconductors, they are ideal candidates for obtaining chiral electron flow leading to functional organic spintronic devices without ferromagnets. Thus the present proposal aims at design, synthesis and characterization of chiral π-conjugated oligomers and polymers with ordered supramolecular organization on surfaces as testbeds for spin-selective electron transport. Chiral fluorene oligomers/polymers are known to form cholesteric liquid crystal phases on surfaces. Based on this, our design includes chiral fluorene based oligomers and polymers attached with pendant acid groups to anchor on surfaces to obtain chiral supramolecular organization desired for the electron-transport. This project will be the first demonstration of chiral-spin selectivity in synthetic self-assembled structures and will pave way for a plethora of spin-based applications.

Mots clés : self assembly, chirality, spintronics, fluorenes

Participants :
- Eindhoven University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet OzoToxID (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Organic micropollutants (MPs) such as pharmaceuticals, industrial chemicals, and biocides cause undesired effects in the aquatic environment when present above certain concentrations. Conventional wastewater treatment plants (WWTPs) are major point sources of entry of MPs into watercourses, leading to disturbances in the ecosystems of receiving water bodies and potentially to a negative impact on the quality of drinking water resources. Several European countries have started upgrading their WWTPs to reduce discharges of MPs into water bodies. Ozonation is one of the two main technologies used to upgrade WWTPs. The abatement of MPs by ozone has been shown to reduce certain toxicities such as endocrine disruption and algal toxicity. However, toxicological studies which investigated mutagenicity and genotoxicty –two endpoints relevant to carcinogenicity– revealed that ozonated wastewater exhibited mutagenic and genotoxic activities, which were not present before ozonation. To date, the nature of mutagenic and genotoxic ozonation transformation products and byproducts (OTPs and OBPs) as well as their precursors has not been elucidated. Owing to the large number of MPs present in wastewater effluents, testing each compound individually is not a feasible option. Consequently, an integrative strategy that prioritizes identification and targets the mutagenic and genotoxic compounds after toxicity assessment is necessary. OzoToxID aims at developing and implementing an integrative bioanalytical strategy based on effect-directed analysis combining mutagenicity and genotoxicity bioassays, fractionation, and cutting-edge high-resolution mass spectrometry chemical analysis to identify mutagenic and genotoxic OTPs/OBPs, determine their precursors, and elucidate their formation pathways. OzoToxID will provide key data that is crucial to determine the feasibility of ozonation when upgrading WWTPs.

Mots clés : water quality, advanced wastewater treatment, ozonation, mutagenicity, genotoxicity, effect directed analysis, transformation products, bioanalytical approach

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Recherche, subvention : 203149.44 €
Projet UMICs (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Organic mixed ionic-electronic conductors (OMIECs) have risen as a promising material choice for bioelectronic devices due to their low impedance, soft mechanical properties, and ability to transduce ionic signals to electronic currents. The ion-electron interactions, which are unique to mixed conductors, have been exploited to produce high performance sensors and electrophysiological recording devices. However, the fundamental interactions between ions and electrons that determine the performance of these materials is still poorly understood, impeding their translation from a research setting to commercial use. This proposal aims to address this gap in knowledge using state-of-the-art analysis of the nanoscale electronic and chemical properties to better understand the macroscale materials performance. The proposed project consists of three central goals: (1) direct observation of nanoscale ion-electron interactions in OMIECs, (2) identifying the relationship between these interactions to OMIEC materials properties, and (3) leverage the findings to optimise next-generation bioelectronic devices. Spectroscopic scanning transmission electron microscopy (STEM) techniques will be used to study the spatial distribution and electronic structure of ions in OMIEC films during operation with ultra-high spatial resolution. Optical spectroscopy and electronic characterisation will be used to study the transport properties of ionic and electronic charge carriers in OMIECs. The work will be supervised by Prof. Malliaras, an expert in both fundamental physics of OMIECs and their clinical applications, Prof. Ducati, an expert in advanced multidimensional STEM techniques, and Dr. Rao, an expert in optical characterisation of organic semiconductors. The fundamental insights drawn from investigating the ion-electron interactions in OMIECs will inform the design of next-generation bioelectronic materials and devices to advance beyond the lab into commercial and clinical applications.

Mots clés : bioelectronics, organic electrochemical transistors, electron energy loss spectroscopy, pedot pss, in situ electrochemistry

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet AiRPaDD (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks - Industrial Doctorates
Panel : Chemistry
Statut du projet : SIGNED

This Action will contribute to the sustainable development of European chemical industries in the coming decades by delivering an ambitious doctoral training programme that draws on expertise from industry and academia across 4 European countries. The research agenda and experiential training will grow the skills base beyond approaches that have relied upon a limited set of molecular scaffolds and a relatively small sub-set of reactions to exploit new reaction paradigms and platforms (e.g. high throughput experimentation, photoredox & electrochemistry) that meet the needs of modern drug discovery science.


Participants :
- Université de Sheffield (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université du Pays basque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 293966.4 €
- AstraZeneca (Sweden) (Suède) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 244758.0 €
- Af chempharm ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Sanofi (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €
Projet EI (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : SIGNED

The European Union has been challenged to contribute to the global aim of providing sustainable solutions to the current and future needs on synthetic compounds and materials in the coming years. The development of sustainable chemical processes is a cornerstone of modern chemistry, emerging as a critical global research focus. By optimizing the use of natural resources and reducing waste and environmental impact, sustainable chemistry addresses pressing societal needs and contributes valuable solutions. In this sense, electrochemistry has been reborn as a very powerful synthetic tool, which allows organic transformations to be carried out using simple electrons as the driving force of these transformations, and it is beginning to play a significant role in both academic and industrial settings. It is therefore necessary to establish strong networking among European research centers and industries focused on the application of electrochemistry in organic synthesis. The EI program aims to create a multidisciplinary training program in which, the students will acquire a deep knowledge of electrochemistry applied to organic synthesis, in addition to highly valued industrial skills, and the establishment of a strong networking in the area. This strong networking will promote the appearance of new research lines and the creation of a highly qualified research training program for PhD students, ultimately positioning Europe as a leader in a hot research field as electrochemistry.

Mots clés : organic synthesis, electrochemistry, electrocatalysis, electro photocatalysis

Participants :
- Synthelia organics sl (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Greenwich (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 348738.12 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, beneficiary, Recherche, subvention : 290272.32 €
- université polytechnique de Łódź (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 251150.76 €
- Université de Strathclyde (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 348738.12 €
- KTH Institut royal de technologie (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 324630.0 €
- Helmholtz-Gemeinschaft (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Göttingen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 290272.32 €
- Université autonome de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 282188.16 €
- Lyon-I université (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 314669.16 €
- Esy-labs gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet AZERO (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Decarbonisation of Aviation will require strict regulation and monitoring to be aligned with the EU Green Deal in making the EU the world’s first climate neutral region by 2050. EU regulation is continuously evolving, affecting key performance indicators (KPIs) used to measure this ambitious objective. The overall goal of this project is to contribute to the decarbonisation of aviation by assessing airline reduction commitments for achieving net zero carbon by 2050.  Applying an interdisciplinary approach, the methodology is divided into three stages: 1) Mapping all the GHG KPIs used by European airlines, to set up targets and follow-up measures; 2) Evaluating the actions taken and planned to reach net zero carbon by European airlines, applying a supervised automatic textual analysis to airline ESG reports - a new source of data not used in the past in the airline industry; and 3) Simulate via traffic scenarios, environmental initiatives and airline commitments to estimate the KPIs feasibility using the System Dynamic (SD) method for the timeframes of 2030, 2040 and 2050. AZERO’s simulation method is more advanced compared to previous research as it uses real airline emission data and plans they have committed to in the ESG reports. It will allow for the updating of the model on a yearly basis when new editions of ESG reports become available.

Mots clés : aviation, emissions, airlines, eu green deal, carbon neutrality targets, sustainability kpis, co2, ghg

Participants :
- Université des sciences appliquées d'Amsterdam (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de la ville de Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet FORCEFuel (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Recently, it has been shown that the local catalyst structure plays a significant role in adsorption energies via the curvature effect. Currently, the curvature effect is mainly based on computational observations. My research objective is to validate my computational model of the curvature effect by experimental testing with Prof. Herrero's group at the University of Alicante. To validate the model, I will use the formic acid oxidation reaction (FAOR), an important reaction for direct liquid fuel cell applications, as the model reaction. The research on validating the curvature effect is timely due to the established advancements in catalyst synthesis and spectroscopical studies. Namely, I will combine experimental methods of synthesising curved catalysts with the recent advancements in spectroscopical studies of electrochemical reactions. The resulting research will provide insights for curvature effect application on fuel cells research via the gained understanding of CO adsorbate energy correlation with curvature, and other electrochemical reactions by increased control of adsorption intermediate energies. During the fellowship, I will acquire new experimental skills in synthesis and surface characterisation. The obtained experimental experience will also further my current computational modelling expertise – directly, by helping to refine the existing computational model for curvature, and, indirectly, by helping to understand the experimental limitations and governing factors that currently might be neglected in modelling.

Mots clés : formic acid oxidation reaction, direct liquid fuel cells, computational electrocatalysis

Participants :
- Université d'Alicante (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €
Projet STEADYDOME (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : TERMINATED

Vaulted structures hold enormous cultural, historical, and artistic value as they constitute one of the main structural elements characterising monumental masonry architecture. Among them, the dome is undoubtedly the most emblematic and prominent one. Preservation of cultural heritage for future generations and its sustainability is one of the major commitments to which our society is called. The seismic vulnerability of some monumental buildings and the great difficulty in estimating their safety level calls for urgent remedies to the current lack of knowledge and technical regulations. The research aims to carry out a systematic series of shaking table tests on scale models, suitably supplemented by a large set of reliable simulated experiments by discrete element models, with the goal of characterising the dynamical behaviour of masonry domes. The ultimate goal of the research is to draw up valuable recommendations for the development of rational regulations, verification criteria, guidelines for professionals and post-earthquake first intervention protocols through the theoretical analysis of the experimental results. The capability to properly evaluate the safety level of masonry domes will enable limiting consolidation interventions to a minimum, identifying with greater precision those cases that really require consolidation, with consequent economic benefits. It will also enable calibrating interventions on the basis of the true behaviour of the structure, avoiding exaggeratedly invasive retrofitting works that distort the original behaviour of the construction, thus being in line with the principle of architectural conservation while simultaneously ensuring the appropriate safety requirements of the building.

Mots clés : masonry architecture, domes, seismic vulnerability, shaking table tests, architectural heritage conservation, dome dynamic response

Participants :
- Université de Loughborough (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université du Minho (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 156778.56 €
Projet SUPREME (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

With more than 13 million people dying per year from infectious diseases Multidrug Resistance (MDR) in bacteria remains the greatest challenge in public health care. This scenario, associated to the low turnover of new clinically approved antibiotic drugs makes the development of innovative therapeutic approaches to fight antibiotic resistance desperately needed to address this devastating societal problem. In this frame, SUPREME aims at the implementation of a novel strategy based on unprecedented supramolecular platforms based on new cyclodextrin polymers integrating light-activatable nitric oxide (NO) photodonors (NOPD), alone and in combination with antibiotics currently employed in the clinic. The final goal is to exploit the double role of NO generated with superb spatiotemporal control thanks to the light triggering, as: i) bactericidal species not suffering MDR when produced at high doses (micro molar); ii) inhibitor of the efflux pumps mainly responsible for MDR, when produced at low doses, to revert antibiotic resistance. Highly biocompatible branched polymers containing mixed (alpha, beta and gamma) cyclodextrin units will be used as suitable hosts able to self-assemble into nanoparticles or gels encapsulating the therapeutic cargo with high efficiency. We will focus on NOPDs activatable exclusively with the biocompatible visible light and on antibiotics representative of the classes of fluoroquinolones and tetracyclines, known to display resistance and severe side effects. Full chemico-physical and photochemical characterization of the systems is planned as well as assessment of their efficacy against planktonic microbial cells and biofilms. The complementary expertise of the researcher and the supervisor supported by the private and academic teams hosting the fellow during secondments will create a multidisciplinary environment where all participants will benefit from reciprocal transfer of knowledge.

Mots clés : light, nitric oxide, cyclodextrin polymers, bacterial infections, mutidrug resistance

Participants :
- CycloLab (Hungary) (Hongrie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Catane (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
- Université de Messine (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €