Projet V.A. Cure (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Vascular anomalies (VAs) is a group of rare diseases defined by blood- or lymph vessel dysfunction causing chronic pain, disabilities, and even sudden death, and for which effective treatments are lacking. The European V.A. Cure network aims to address this unmet medical need by uncovering core mechanisms of disease initiation and maintenance and by leveraging this information for establishing novel therapeutic strategies for VAs. V.A. Cure has assembled 7 world-leading academic laboratories and 5 companies, which will apply an intersectoral four-step approach: (1) identification of novel genes involved in VAs in patients, (2) dissection of molecular mechanisms behind the diseases by in vitro modelling, (3) in-depth analysis of tissular mechanisms in pathophysiological conditions through in vivo models, and (4) pre-clinical testing of identified treatment strategies. The knowledge gained will not only be relevant for VAs but also for understanding aberrant vascular function in other vascular-related diseases. The composition of V.A. Cure and close interaction between the 14 ESRs, through secondments in academia and industry, guarantee a unique intersectoral training program at the highest level, ensuring a comprehensive perception of research and drug/technology development in pharma industry/biotech and academia. ESRs will be trained in a plethora of cutting-edge technologies including next-generation sequencing (up to single-cell RNA-Seq), CRISPR-Cas genome editing, generation of animal models with inducible deletion and mosaic analyses, generation of iPSCs, microfluidics, in vivo phage display to identify endothelial targets, and light sheet-, confocal-, and multiphoton live-imaging. In combination with advanced training in management and communication including writing, presentation, e-media and outreach, the graduates of the V.A. Cure network will be future leaders in vascular research, and also highly competitive candidates for positions outside academia.

Mots clés : vascular development, vascular anomalies, genetics, imaging, animal models, cellular models, next generation sequencing, molecular therapy, somatic mutation, repurposing of drugs

Participants :
- University of Potsdam (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 505576.8 €
- Singh prateek (Finlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 280805.76 €
- AstraZeneca (Sweden) (Suède) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 563965.92 €
- Uppsala University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 563965.92 €
- Perimed (Sweden) (Suède) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Olink Bioscience (Sweden) (Suède) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Belgian vascular anomaly patient association (Belgique) — Partner, organization partner, Autres, subvention : 0.0 €
- Cliniques Universitaires Saint-Luc (Belgique) — Partner, organization partner, Recherche, subvention : 0.0 €
- Bayer (Germany) (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Lls rowiak laserlabsolutions gmbh (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Oulu (Finlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 280805.76 €
- Sysmex inostics gmbh (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Max Planck Society (Allemagne) — Partner, beneficiary, Recherche, subvention : 252788.4 €
- Tampere University (Finlande) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Karolinska Institutet (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281982.96 €
- de Duve Institute (Belgique) — Coordinator, beneficiary, Recherche, subvention : 512640.0 €
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 549604.08 €