Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CASTedit (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The rapid advancements in CRISPR-Cas technology have revolutionized gene editing, yet significant challenges persist, particularly the reliance on DNA Damage Response (DDR) pathways and the limitations in integrating large DNA segments. These constraints hinder the application of CRISPR-Cas systems, especially in non-dividing cells and complex genomic modifications. The recently discovered CRISPR-associated transposon (CAST) systems offer a transformative solution, enabling the insertion of large DNA cargos (10–30 kb) into specific genomic locations without inducing double-strand breaks (DSBs), thereby providing a safer and more versatile genome-editing tool. The CASTedit project aims to repurpose CAST systems as next-generation genome editing tools, with a focus on mammalian cells. Specific objectives include the development of engineered CAST systems (Types V-K and I-D) for precise DNA integration, the exploration of novel CAST complexes for RNA-guided transposition, and their validation at the organismal level. Successful implementation of these systems in eukaryotic cells could overcome current CRISPR limitations, paving the way for innovative applications in cell engineering, regenerative medicine, and biotechnology. Under the guidance of Prof. Guillermo Montoya, a leading expert in the structure-function analysis of nucleases, and with his pioneering research in CAST complex assembly at the University of Copenhagen, I will be well-positioned to achieve the goals of this project. I will leverage my expertise in CRISPR-based genome editing, protein expression systems in eukaryotes, and high-throughput mutant screening to optimize CAST systems for precise DNA integration in mammalian cells. The successful execution of CASTedit will establish me as a prominent researcher in genome engineering, utilizing the host institution’s state-of-the-art facilities and collaborative environment to drive innovation in therapeutic applications.

Mots clés : crispr cas, crispr associated transposons, rna guided transposition, genome engineering, dna integration, mammalian cells, tn7 transposons

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 247553.28 €
Projet RESET (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

In the Anthropocene, global and local cumulative human pressures are heavily impacting ecosystems and threatening societies. Maintaining resilience, i.e. avoiding irrevocable system changes, is the only way to maintain the critical services that an ecosystem provides, and should be an objective of management. Recently, resilience has been deeply studied theoretically sparking interest in the whole scientific community. However, its integration into management practices is still rare due to methodological limitations. Standardised and applicable methods to estimate resilience empirically in natural systems are lacking. RESET will develop a framework to concretely estimate resilience in marine ecosystems and integrate it into management. The framework will be built on high-quality and innovative statistical methods and on the Local Ecological Knowledge (LEK) of fishers. The work will be carried out in Chioggia, a city hosting a major Mediterranean fishery and a perfect location where Universities, research institutes, fishers and management bodies have a long story of collaborations. Using long-term time series of the Northern Adriatic Sea, an ecosystem hotspot of global changes and human pressures in the Mediterranean Sea, RESET will apply a three-step modelling approach to estimate resilience. The knowledge deriving from the modelling approach will be complemented with the LEK of fishers synthesised through structured interviews and participatory meetings. The inclusion of fishers in the process will favour a more proactive management approach. Finally, RESET will readily transfer the new methodologies and knowledge into management by cooperating with ISPRA, the Italian Public Body responsible for the application of the Marine Strategy Framework Directive, the ecosystem-based management approach of the EU. The realisation of these three objectives will favor the integration of different approaches which is fundamental in order to sustainably exploit our resources.

Mots clés : resilience, temporal and spatial regime shifts, marine ecosystems and populations, local ecological knowledge, tipping points, marine management

Participants :
- Institute for Environmental Protection and Research (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet DaShoW (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The stereotypical representations of Italians as racially inferior and dangerous for public security saturated the American public discourse at the end of the Reconstruction (1877) and tragically materialized in 1891 when 11 Italian Americans were lynched in New Orleans. The racial landscape of the Crescent City is exemplary of the Italian migrants’ struggle for acceptance across the South and can be fruitfully used as a testbed to study the intertwining of diaspora and race both in the Gulf South and nationally. Through the study of the public discourse emerging from rare and still understudied Italian-language ethno-cultural periodicals published in Louisiana and widely distributed outside the state, DaShoW illuminates how the shifting discourses on Africans, African Americans, Native Americans published in the Italian-language periodical press contributed to ‘manufacture, assert and defend the Italian race’ within one of the largest diasporic Italian communities in the United States. The project will demonstrate how the racialization of Southern Italians in New Orleans and Louisiana was the result of the appropriation of stereotypes rooted in the North/South post-Risorgimento divide transposed from Italy and rhetorical strategies ascribable to the Italian Positive School of Criminology. DaShoW will study the rhetorical and practical strategies through which the Italian communities of Louisiana and the Gulf South negotiated their racial standing between 1877, which ended the Reconstruction thus paving the way for the deprival of African Americans’ voting rights, and the formation of an early Southern civil right movement (1945). DaSHoW promotes a comprehensive framing of the Italian diasporic presence in the racialized geographical, social and cultural context of the Gulf South and aims to preserve and popularize perishable documents for the study of Italian emigration through the digitization of primary sources and the production of digital learning tools.

Mots clés : history of italian migrations, italian ethno cultural press in north america italians in the american south, racial positioning, blackness, whiteness

Participants :
- Seton Hall University (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €
Projet LASERGWO (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

The Laser Interferometer Space Antenna (LISA), a milli-Hertz gravitational wave (GW) observatory, has extraordinary scientific potential. It is expected to revolutionize multimessenger astrophysics in the mid-2030s through synergies between LISA and both space- and Earth-based electromagnetic (EM) observatories. Mergers of supermassive black hole binary systems will be primary sources for these multimessenger studies. LISA will detect GWs emitted during the pre-merger phase and pinpoint the source location, allowing EM observatories with narrow fields of view to search for potential counterparts. For this synergy to be effective, rapid alerts of sky positions and coalescence timing are crucial—not only at the moment of merger but also in the hours leading up to it, when precursor signals may occur. This raises a vital question: what strategies or technologies will ensure that EM observatories are prepared to respond in nearly real time?  My project addresses this urgent need by developing a low-latency alert pipeline (LLAP). Unlike detailed astrophysical analyses, which can be adjusted post-event, the LLAP must be operational from the start of LISA’s mission to enable prompt identification, analysis, and follow-up of transient events. This pipeline will leverage deep learning algorithms to process LISA’s raw phasemeter data and generate posterior parameter distributions for binary coalescences. This novel approach bypasses standard initial data processing stages, aiming to reduce alert latency for EM observatories. Moreover, it integrates data analysis tools and hardware, as the LLAP will be validated using experimental data from a Field-Programmable Gate Array-based LISA Delay Hardware Simulation developed at AEI Hannover. This experiment simulates onboard measurement chains and allows for real-time injection of GW signals during hardware testing. LASERGWO will pave the way for future multimessenger observations.

Mots clés : lisa, gravitational waves, multi messenger astronomy, bayesian data analysis, low latency pipelines, deep learning, lisa hardware simulation, time delay interferometry, noise reduction techniques

Participants :
- École polytechnique fédérale de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 393181.44 €
Projet SculpSi (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

SculpSi aims at reconstructing the lives and the works of Greek and Roman sculptors between the Hellenistic period and the reign of Hadrian (323 BCE-138 CE) in the areas corresponding to Roman Italy and the provinces of Achaia and Asia. SculpSi focusses on sculptors’ signatures, taking them as a source of information and a starting point for reconstructing their professional careers: signatures open up many research paths that have yet remained unexploited: their wording, their position on statues or bases, palaeographic dating, language and dialect, etc. They can also help us to reconstruct the work of individual sculptors, attribute them specific artworks and track their mobilities in the Mediterranean. SculpSi will be the first systematic study on sculptors’ signatures between 323 CE and 138 CE: the analysis will be carried out on a corpus of ca. 550 signatures, and will be based on bibliographic data and, whenever relevant, autoptic study; such data will be used to feed Polycles, a prosopographic database already created by the LIMC team at my host institution, but still awaiting launching. The project breaks down disciplinary barriers by combining art history, epigraphy, archaeology, and digital humanities and posing theoretical questions (e.g. role of the artist within society, the idea of authorship) which go well beyond Classical studies. The database -only one of the research products of Sculpsi- will constitute a perennial gate for scholars and students of several disciplines, giving access to data scattered in different parts of Europe and beyond and to the first English and French translations of many inscriptions. Besides being trained in digital humanities, the researcher will develop a unique expertise in Epigraphy and ancient Art History, filling a gap between disciplines which rarely communicate. Collaborations with international museums and academic institutions will open up several opportunities for the researcher, both in France and abroad.

Mots clés : digital humanities, greek and roman sculpture, iconography, epigraphy, classical antiquity, art criticism

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
- Université Paris Nanterre (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet INFRAFRICA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

China’s increasing presence in Africa through the Belt and Road Initiative has raised concerns about the development, governance, and foreign policy implications of Chinese-financed, Chinese-built infrastructure projects. At a time in which the European Union is putting African infrastructure investments at the centre of its Global Gateway initiative, my INFRAFRICA project— a comparative study of foreign-financed and foreign-built infrastructure in Africa: perspective from Ethiopia and Angola—expands current knowledge about foreign engagement in the African infrastructure sector. By taking the infrastructure sectors of Ethiopia and Angola as case studies, INFRAFRICA aims to contribute to three interconnected debates. First, the project evaluates the impact of foreign construction firms’ operations on the host countries’ economies. To do so, INFRAFRICA explores and compares the behaviours of Chinese firms with other foreign infrastructure firms at the micro level through critically evaluating the formation of local economic linkages. Second, INFRAFRICA explores the modalities of foreign engagement in the two African countries by investigating ways in which African state and nonstate actors negotiate with, accommodate, and contest foreign actors involved in the financing and building of infrastructure projects. Third, through exploring the political, institutional, economic, and legal contexts of the two countries, INFRAFRICA identifies the barriers that shape the negotiation, implementation, and outcomes of foreign-financed and foreign-built infrastructure projects in Africa. In carrying out my research, I will be based at the Robert Schuman Centre for Advanced Studies at the European University Institute, where I will work under the supervision of Professor Bernard Hoekman.

Mots clés : china africa relations, african agency, infrastructure development political economy of development, development finance, economic linkages belt and road initiative, global gateway initiative

Participants :
- Institut universitaire européen de Florence (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180790.08 €
Projet MS2DCOFO (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

MS2DCOFO will offer a highly talented and promising young researcher with a PhD in chemistry and an outstanding track record a world-class training through research in the cross-disciplinary, supra-sectoral and burgeoning field of multifunctional 2D semiconducting covalent organic frameworks (COFs). MS2DCOFO’s overall mission is to coach the fellow to become a mature and independent scientist and to prepare him for a leading position in academia or industry in Europe. Organic field-effect transistors are crucial elements for the fabrication of flexible, wearable, and biocompatible electronic devices. As miniaturization is approaching its limits, bringing an end to Moore’s law, beyond-CMOS devices, “More-than-Moore” technologies aimed at functional diversification are emerging as technologically viable strategy to boost the data storage capacity in tomorrow’s digital electronics. 2D COFs, as crystalline porous organic polymers built by covalently connecting organic building units, represent ideal platforms to incorporate simultaneously different switchable units into a given 2D skeleton with a atomically precise and robust structure. Thus, on the long term, multiresponsive semiconducting 2D COFs can become crucial components in neuromorphic devices and synaptic arrays to meet the present and future requirements of higher computational density that cannot be achieved by scaling down CMOS transistors. In this framework, the making of multiresponsive semiconducting 2D COFs represents a grand challenge that can offer a major technological advancement for next-generation electronic devices. Towards this ambitious goal, we will first design and synthesize multiresponsive 2D COFs, whose switchable properties and stabilities will be carefully characterized. The related high-quality 2D COF films fabricated via interfacial, in-situ solvothermal, or exfoliation methods, will be integrated and tested into multifunctional semiconducting devices for complex logic operations.

Mots clés : two dimensional covalent organic frameworks porous crystalline materials responsive materials fabrication of polymer films switchable optoelectronic devices

Participants :
- Graphenea (Spain) (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Strasbourg (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet ImMiRevKPTM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Nature makes use of covalent additions of functional groups to proteins for regulating essential processes like cellular signalling and protein folding/degradation. Most of these post-translational modifications (PTMs) are enzymatically-reversible, with the coupled catalytic processes being fulfilled by antagonistic enzymes (e.g., methylase-demethylase pair). This dynamic behaviour allows for the correct metabolic equilibrium, as an unbalanced PTM-machinery is indicative of some severe diseases. Such a complex auto-regulated system is the result of millions of years of evolution that has allowed for highly efficient and site-selective functionalizations. Nevertheless, selective covalent bond formation in a substrate with multiple competitive sites is an intricate endeavour in the absence of auxiliary enzymes or other sacrificial agents. Dynamic Covalent Chemistry could be a major asset for overcoming this research bottleneck, as the reversible nature of the reactions involved can drive the functionalization to the most thermodynamically favoured site. Most proteins contain Lys (K) residues with terminal amino groups suitable for derivatization. In particular, histone K-PTMs are crucial for controlling gene expression, with the most common modifications being acetylation and methylation. The proposed work will explore the reversible modification of histones using aldehydes that contain within their structure the functional groups required for the recognition by biological “readers”. For instance, aldehydes with carboxylate and trimethylated ammonium groups will be examined to mimic naturally occurring K-succinylation and K-trimethylation. This approach is still unexploited due to the lability of imine bonds in physiological water. However, several important biological processes are governed by the formation of imino/iminium reversible bonds with pyridoxal-5′-phosphate (PLP) derivatives, inferring that this sort of chemistry is possible in protein microenvironments.

Mots clés : dynamic covalent chemistry constitutional dynamic chemistry host guest molecular recognition imines self sorting combinatorial chemistry macrocycles bioorganic chemistry bioconjugations histones

Participants :
- Université de Strasbourg (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet Reagentless-Org-Synt (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

This project proposal, "Reagent-less Organic Synthesis through Vibrational Strong Coupling," addresses the pressing need in synthetic chemistry for sustainable and environmentally friendly chemical transformations. It aims to harness the power of vibrational strong coupling (VSC) to enable reagent-less, clean chemical reactions with maximum atom economy and minimal waste generation. VSC involves selectively coupling a molecule's vibrational transition to the zero-point electromagnetic fluctuations of an optical cavity. This coupling, even in the absence of light, creates vibro-polaritonic states that can alter the ground-state reactivity landscape. VSC being a nascent field has shown promise in modifying some chemical reactions, however, many fundamental questions remain unanswered. The research plan combines the fabrication and characterization of optical cavities, monitoring coupling strength and reaction kinetics using FT-IR spectroscopy, product characterization with GC-MS and NMR spectroscopy, and advanced spectroscopic techniques. Collaboration with experts in computational quantum physics will bridge the gap between theory and experiment. This project's innovative aspects lie in its potential to achieve selectivity in chemical reactions that are challenging or impossible through conventional methods, eliminating the need for expensive catalysts, hazardous reagents, or harsh conditions. By exploring a range of reactions and studying the underlying principles, this project contributes to sustainable chemical synthesis, aligning with the goals of circular economy strategies and innovative energy-efficient practices.

Mots clés : polaritonic chemistry, strong coupling, product selectivity, organic synthesis, vibrations, 

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Strasbourg (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €