Projet OrganoVIR (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

OrganoVIR (Organoids for Virus Research) will train young researchers (ESRs) in the field of organoids and virology. Human viral infection studies lack suitable experimental models as animal models or conventional 2-dimensional (2D) cell cultures do not translate to human infection. OrganoVIR makes use of the breakthrough in the culturing of primary human cells into 3D cultures (organoids). Within this ETN programme, organoids will be used for the first time to study human viral infections in their natural environment. OrganoVIR includes leading partners in virology and organoid technology covering 7 academic institutes, 3 life science companies, 1 organoid technology private company, 2 non-profit organisations, a national public health institute and a business school originating from 8 countries. The aim is to introduce and establish human organoids as superior models for viral pathogenesis studies and antiviral testing, thus replacing animal models and reducing animal use. OrganoVIR provides a full package ETN programme for ESRs to learn the science of innovative 3D culture systems for virus research as well as financial, commercial, ethical, communicative, policy and dissemination aspects for optimal valorization. The projects are intensified by significant secondments at commercial, governmental and non-profit partner institutes. OrganoVIR provides: - High-ranked scientific and technical training in an interdisciplinary, intersectoral and international top research project - Training in transferrable managerial skills, including a pre-MBA - Implementation of innovative organoid technology for viral pathogenesis studies and antiviral development - Innovation in organoid technology by co-culture design and high throughput screening. OrganoVIR combines frontier research with an innovative training programme in a complementary network, certifying high impact scientists.

Mots clés : virology, pathogenesis, 3d cell culture, organoids, antivirals, viral entry, high throughput, pre, personalized journey

Participants :
- University of Geneva (Suisse) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281276.64 €
- KU Leuven (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 768960.0 €
- Jagiellonian University (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 454957.2 €
- Epithelix sarl (Suisse) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Amsterdam University Medical Centers (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 531239.76 €
- Organome llc (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Stemcell technologies uk ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 303172.56 €
- University of Amsterdam (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 265619.88 €
- Charles river nederland bv (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 265619.88 €
- Technical University of Denmark (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 297522.0 €
- Stichting proefdiervrij* dutch society for the replacement of animal testing (Pays-Bas) — Partner, organization partner, Autres, subvention : 0.0 €
- Université Clermont Auvergne (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 549604.08 €
- Utrecht University (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 265619.88 €
- Royal Netherlands Academy of Arts and Sciences (Pays-Bas) — Partner, organization partner, Recherche, subvention : 0.0 €
- National Institute for Public Health and the Environment (Pays-Bas) — Partner, organization partner, Recherche, subvention : 0.0 €