Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet NEANDER-TALe (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Neandertals inhabited Eurasia for around 200 thousand years (between c 250ky and 50 ky ago), in very different ecosystems, in a period with changing climates. They are probably the most studied extinct human group due to the richness of its fossil record, their chronological overlap with modern humans, and because the admixture between both groups has important implications regarding modern human genetic diversity. Their overall anatomy significantly differs from that of modern humans, and concretely the cranium shows a distinct morphology that help to characterise this group. Nevertheless, the way that this human lineage evolved and the origin of this specific morphology is a matter of intense debate in the field of Human Evolution. In this sense, the cranial morphology of the first Neandertals sensu stricto (Marine Isotopic Stage (MIS) 7-6, late MP) has barely been described using state-of-the-art techniques. Centered on the study of the Abri Suard site (Charente, France) cranial remains, this project aims to study the first Neandertal representatives from a key region. Their cranial morphology will be analysed using cutting edge Virtual Imaging Techniques (VIT). This will allow us, for the very first time, to determine the tempo and mode of apparition of the typical Neanderthal cranial features. The fellow will receive training on multi-disciplinary state-of-the-art Paleoanthropological and Virtual Imaging Techniques. In turn, he will transfer his expertise in physical and forensic anthropology, as well as in Prehistoric Western Europe human groups. He will expand the analyses VITs to periods not previously explored by the host. In addition, he will foster new collaborations with academic (secondments) and non-academic partners (museums, heritage associations). Altogether, this project guarantees the two-way transfer of knowledge and represents a solid investment of funds from which the fellow, the host institutions and the European society will largely benefit.

Mots clés : human evolution, virtual imaging, microtomography, middle pleistocene, southwestern europe

Participants :
- Université de Bordeaux (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €
Projet NeMeCo (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

Near Memory Computing: Major bottlenecks for future computation is the slow communication over slow interconnects between big data memories and big data processing and also the slow overhead of data memory accesses. The NeMeCo EID network aims at solving this problem by proposing fundamentally different architectures, integrating computation and memory, and using reconfigurable accelerators. Research topics of this project are: new, non-Von-Neumann architectures, automated design of reconfigurable accelerators, advanced memory hierarchy based on both volatile and non-volatile memory components, and corresponding compiler, algorithmic optimization and mapping techniques.

Mots clés : big data computing, non von neumann architectures, reconfigurable accelerators, advanced memory hierarchy, run time managers, algorithmic optimization, automated software mapping

Participants :
- Eindhoven University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 766122.84 €
- IBM Research - Zurich (Suisse) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
Projet NIR-BIO-FLU (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Near-infrared (NIR) fluorescence molecular imaging is a supra-discipline that enables visualisation of cellular function and real-time tracking of molecular processes in living organisms without perturbing them. If exploited to its maximum potential, NIR-fluorescence could have hugely positive impact for early stage diagnosis of diseases such as cancer, neurological and cardiovascular disease, the optimisation of preclinical and clinical tests for new medication and act as a real-time guide during surgery. This proposal seeks support for a MSC Fellowship to develop new biologically responsive off to on switchable NIR fluorochromes i.e. NIR fluorescent probes that respond selectively to cellular uptake and with specificity for cancer cells achieved through bio-conjugation with proven targeting agents. Specifically, the focus is on the design, synthesis, photophysical characterisation, in vitro cell imaging and preliminary in vivo assessment of such probes for the ultimate in vivo detection of colorectal cancer metastasis. Colorectal cancer is the third most common cancer and remains a major public health issue in Europe because of its high prevalence, morbidity, and mortality. The synergetic combination of the host laboratory’s interdisciplinary expertise, the host institution’s ability to deliver a comprehensive training program and the applicant’s excellent prior Ph.D. training experience in developing fluorescence chromophores with function-tailored photophysical properties is the perfect match to deliver the project goals and provide the stepping stone to independent researcher for the applicant.

Mots clés : azabodipy, near infrared, fluorescence, bio conjugation, imaging, colon cancer

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
Projet SchiSTOP (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Neglected tropical diseases (NTDs) are a diverse group of infections which are especially prevalent in low-income populations in tropical and subtropical areas in Africa, Asia and the Americas. Schistosomiasis is the deadliest NTD killing an estimated 280,000 people each year in the African region alone. The World Health Organization (WHO) 2020 target for schistosomiasis is to reduce the prevalence of heavy-intensity infections to ≤5% among school-aged children through Mass Drug Administration (MDA). However, in areas of moderate and high prevalence the goal seems unlikely to be met as even with intensive biannual MDA, prevalence of infections are still seen to rebound rapidly after each round. The reasons are still poorly understood. Mathematical models and statistical methods have proven to be essential to gain insights into the complex processes underlying the transmission dynamics of infectious diseases. In this research project, I will develop a stochastic individual-based model (IBM) to simulate schistosomiasis transmission integrating cutting-edge mathematical models and statistical methods with recent advances in parasite genetics, epidemiology, diagnostics and immunology. This project aims to advance our current understanding of schistosomiasis transmission dynamics investigating the mechanisms that cause the rapid rebound of prevalence after MDA and proposing optimal implementation of current and novel strategies to achieve schistosomiasis control and move towards elimination. In addition, this project will build a reference methodological framework to comprehensively study other MDA targeted infectious diseases. The proposed project addresses one of the priorities of the EU, through global poverty reduction (SDG goal 1) by promoting ways of improving future health (SDG goal 3).This project will be carried out at Erasmus MC with Prof. Sake J. de Vlas and at University of Glasgow (secondment) with Dr. Poppy Lamberton.

Mots clés : neglected tropical diseases, schistosomiasis, infectious disease epidemiology, mathematical modelling, bayesian biostatistics

Participants :
- Radboud University Nijmegen Medical Centre (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175572.48 €
- Erasmus MC (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet CLEA (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Neglected use of materials in conservation and restoration of building surfaces are reducing authenticity value in many urban landscapes. Colour Science, Architectural Paint Research and Instrumental Analysis Techniques have been mostly applied in the study of architectural finishes. However, there’s not a standard operational framework to inform decision-making in finishes conservation. CLEA aims to address these shortcomings and to preserve authenticity by the use of innovative paths (1) to improve the methodology for the characterization of architectural finishes, (2) to understand historic pigment use, mortar composition and render texture, (3) to produce a tool for decision making when selecting materials and pigments for the conservation of the historic aesthetic. CLEA will focus in Alexandria, Egypt. Domestic buildings (end 19th-early 20th) were built by Italian, Greek, British and French immigrant architects and are located in the ‘European city’ district. A large range of analysis techniques will be used at the University of Padua, integrating non invasive/on-site (portable XRF, Raman and multispectral imaging) and off-site analysis (Optical Microscopy, Scanning Electron Microscopy, XR Diffraction, 3D laser confocal scanning microscope and radiocarbon dating). Results will help to understand and to preserve original aesthetics by conservators, organizations and people. CLEA actions are aligned with the EU Council on European Cultural Heritage Strategy, encouraging a wider understanding of heritage values and reinforcing European global leadership in the word. The project has active interest in conserving the vision of European building heritage, goal on sustainable cities and communities within the United Nations 2030 Agenda for Sustainable Development. CLEA will strongly contribute in the development of my research career, increasing interdisciplinary expertise, transferable skills by advanced training and providing inter-sectorial experience by secondment

Mots clés : architectural finishes, historic mortars characterization, colour layers, building heritage, non invasive techniques for the conservation, off site analysis

Participants :
- University of Padua (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 275209.92 €
Projet LUNA (Horizon 2020, appel à projets 2018)
Action : European Researchers' Night
Statut du projet : CLOSED

Neither the promotion of science and research nor innovation are a priority in South Tyrol, a land of around 500,000 inhabitants with traditions in agriculture, skilled crafts and trades. Those committed to promoting research in the region try to engage both politicians and the general public by means of a wide variety of activities. One particularly important crowd-puller is the biennial Researchers' Night (LUNA) in Bozen-Bolzano. The Eurac Research - unibz - IDM consortium together with other partners will be opening their doors for the sixth time on September 27 2019, allowing visitors to have a proper look at the work of the scientists, to enter into discussions with junior and senior researchers and conduct experiments with them, to be amazed and to have fun. In addition, LUNA 2018 will be one of the rare opportunities for the public to visit the new NOI Techpark, where the most important South Tyrolean players in science and innovation will have their offices and laboratories and will work together intensively. As usual, all venues (the headquarters of the consortium partners and of 10 additional partners) will be linked by a free shuttle bus service. The Awareness Campaign will target around 300,000 people. The ever growing visitor numbers of the previous events (in 2014 the record number of almost 16,000 visitors was reached!) suggests that we should expect at least 10,000 interested individuals who will be keen to join us. This year's theme is "Change and Challenge", and from 17:00 until midnight, young and old will be able to see for themselves how South Tyrol's researchers play their part in studying the changes in our world (e.g. changes in society, climate change etc.) and in facing the challenges of the future, elaborating possible solutions for all of us. Interactive stands, competitions, games, shows and discussions will offer something for everyone, and above all provide personal contact with around 300 scientists and technicians.

Mots clés : european researchers night, 2018, biennial, luna, bozen bolzano, south tyrol, change and challenge, edutainment, discussions, experiments, interactive demonstrations, hands on, free shuttle service

Participants :
- Idm suedtirol - alto adige (Italie) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- European Academy of Bolzano (Italie) — Coordinator, beneficiary, Recherche, subvention : 52062.5 €
- Free University of Bozen-Bolzano (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 22312.5 €
Projet Neo-Ottomanism (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Neo-Ottomanism (NO), the aim to revitalize the Ottoman imperial past in contemporary Turkish society, constitutes the ideological basis of the populist authoritarianism of the AKP, the ruling Islamist party in Turkey, since 2007. Thanks to its spread in the cultural field, chiefly in TV series, it has been gaining increasing popularity in Turkey and its diaspora. Considering its nationalist and Islamist roots, claims of authenticity and uses of history and nostalgia, which work to legitimize gender inequalities, and also the gender-blind scholarly approaches to it, this project aims to elucidate the gendered nature of NO and how Islamist women, who mostly support the AKP, become creative agents in its reproduction. The project will examine gendered aspects of neo-Ottomanist nostalgia and their sophisticated transmission in Islamist women’s periodicals in Turkey. Its novel insights will fill the critical lacuna of a gender study of NO and provide a more complex image of “Islamist women”. Its research methodology includes content analysis of articles containing Ottomanist nostalgia for discursive, visual, and paratextual reproductions; and interviews with their authors to reveal their perceptions of and nostalgia with Ottoman past and the process of their active involvement in NO’s popularization. The findings will link with Turkish studies, South-East European studies, and studies of gender, media, and cultural heritage; and reach to feminist groups, journalists, policy makers, teachers of religion and fashion lovers. As a researcher who has worked on the subjects of power and discourse, women and Islam in Turkey, and NO and nostalgia, I have essential knowledge, experience and enthusiasm for the project. It will be a unique career opportunity as it will equip me to take part in collaborative research projects and apply for tenured posts in EU. The supervisor and the hosting research centre offer the best possible interdisciplinary expertise and academic networks.

Mots clés : islamism, turkey, neo ottomanism, women s media, nostalgia, critical heritage

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 219312.0 €
Projet NETWORKS (Horizon 2020, appel à projets 2019)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

Networks for communication, transportation, finance and energy form the backbone of modern society. Reliable and efficient network infrastructures are of enormous economic and social value, and their importance will only increase in the coming years. A generation of highly skilled networks researchers is therefore urgently needed. These researchers should have a deep understanding of methods to optimize network performance, to control processes running on networks, and to predict how these processes will evolve over time. Our doctoral program will train 14 such researchers, who will gain the necessary scientific knowledge and professional skills for a successful career inside and outside academia, and who will contribute to the challenges posed by complex networks, by performing top-level research in an international environment. The duration of our program is 60 months, at the beginning of which two calls will be opened to appoint the 14 ESRs. They will obtain their PhD degree after 4 years’ training, the nominal duration in the Netherlands. Main objectives. The main objectives of the NETWORKS doctoral program are: - To bring together expertise from two different disciplines, namely mathematics and computer science, and train our ESRs by performing world-class research in, and at the interface between, these disciplines. - To attract talented young researchers and offer them the best possible training and career perspectives. The extensive training program developed by NETWORKS includes scientific training, a broad range of key professional skills, and personal development. - To stimulate transnational and intersectoral mobility and knowledge transfer. NETWORKS will attract young researchers from outside the Netherlands. Our international network will provide them with excellent additional opportunities for transnational mobility. Intersectoral mobility and knowledge transfer are ensured through secondments at industrial and other non-academic partners.

Mots clés : mathematics, computer science, stochastics, algorithms, complex networks, network science

Participants :
- Eindhoven University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1518720.0 €
Projet NeurTransHet (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

NeurTransHet will shed light on the heterogeneity of neuronal transplantations and the relationship with their environment. The aim of this project is to bring neuronal transplantation closer to clinical implementation by understanding the intricacies of individual transplanted cell contribution, and later applying this knowledge to engineer them. Neuronal loss underlies various brain disorders, such as Alzheimer’s disease, and injuries, such as traumatic brain injuries, resulting in life-long impairment. For example, dementia, a widespread (a new case every 3 seconds worldwide) condition stemming from neuronal loss, has devastating effects on the patients, their families and their communities. Thus, approaches aiming at replacing the lost neurons by transplantation are not only attractive from a health perspective, but also from a socio-economic standpoint. Many studies have explored neuronal transplantation, albeit with varying degrees of success. This is due to a lack in our understanding of how transplants integrate and interact with their host environment. Additionally, several studies gave evidence that transplanted cells are a heterogenous population, however, so far this heterogeneity has not been addressed in terms of function on integration and interaction. The recent advent of single cell transcriptomic technology, coupled with imaging techniques providing high-resolution spatial information, makes it possible to go beyond global interaction and closely dissect the individual neuronal transplants and their environment. Moreover, the possibility of transplanting cells of human origin in mice increases the clinical relevance of the results. During this two-year fellowship under the supervision of Prof. Dr. Magdalena Götz, who is a world-renowned scientist in neuronal cell replacement methodologies, I will transition into an independent research group leader investigating the role of cell heterogeneity in disease.

Mots clés : neural transplantation, human induced pluripotent stem cells, traumatic brain injury, neural cell therapy, single cell investigation

Participants :
- Ludwig-Maximilians-Universität München (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162806.4 €
Projet NeuroStemX (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Neurological and mental disorders are top priorities for the European Commission, which actively invests in research aimed at better understanding brain function and dysfunction, and at finding new therapies for brain disorders. Fragile X syndrome (FXS) is the major monogenetic cause for intellectual disability and is frequently associated with autism spectrum disorder. The trinucleotide repeat expansion, methylation and epigenetic silencing of fragile mental retardation 1 (FMR1) gene promoter leads to the loss of the corresponding protein. However, the molecular mechanism and the timing leading to FMR1 silencing are still unknown due to the absence of reliable in vivo and in vitro models. The recent development of naïve PSCs showing a broader unmethylated genome (including in FMR1) opened a new hope for disease modeling of FXS, but data are still partial and contradictory. The NeuroStemX project aims at filling this gap taking advantage of an optimized technique for the generation of naïve iPSCs developed at the University of Padova (UniPd) and generation of FXS neurons with various approaches mastered by the Experienced Researcher (ER) in conjunction with the microtechnologies developed by UniPd. In particular, we aim at 1) identifying the timing of FMRP silencing during neural development using naïve iPSCs and 2) establishing a reliable in vitro system to model neuronal defects observed in FXS patients. In this project, we are addressing some of the most crucial problems related with FXS pathogenesis and modeling using a variety of innovative approaches. This will give the ER an outstanding training-through-research opportunity by means of a personalized multidisciplinary project, in which the ER will enlarge her scientific competences and strengthen her professional profile. The training includes both scientific and transferable skills, aimed at the reinforcement of the ER professional maturity and independence.

Mots clés : fragile x syndrome, na ve ipscs, in vitro modelling, neuronal differentiation

Participants :
- University of Padua (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183473.28 €