Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Pathfinder (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The long-term vision of Pathfinder is to kick-start a wireless 2.0 paradigm where wireless channels will adapt to the operation of cellular networks, allowing networks to overcome the inherent limitations imposed by wireless channels hitherto. In this course, Pathfinder builds upon the advancements in the area of electromagnetic meta-materials that can control and manipulate radio waves. This technology allows for designing and fabricating software reconfigurable intelligent meta-surfaces (RISs) that dynamically optimize the wireless channels in response to the dynamic behavior of radio waves, showing an unprecedented potential to control waves from within the wireless channels. This control allows for radio waves to circumvent physical obstacles, improving network coverage, while the phase alignment of RIS constituent elements can maximize the power at the receiver through constructive interference. This, can increase data-rates and reduce the transmit power. Furthermore, sensors and IoT devices can “recycle” and backscatter the ambient radio waves through RISs instead of generating their own, realizing the objective of smart, interconnected cities by employing passive elements that neither generate radio waves nor consume power to generate them. In this setup, the overarching objective of Pathfinder is to set the theoretical and algorithmic foundations of RIS enabled wireless 2.0 networks by deriving: (1) physics-inspired models for the RIS/radio wave interaction. (2) communication & information-theoretic models for RISs networks. (3) models for large-scale analysis of RIS networks. (4) algorithms for the design and optimization of RIS operation. (5) measurements for the experimental verification of the developed models and algorithms. The realization of these objectives can indeed transform wireless networks, driving the economic and intellectual growth of all European society, creating new jobs, increasing revenues and simplifying our lives.


Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 184707.84 €
Projet MuSCel Genome (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The loss of structural integrity in the interphase nucleus leads to tissue-specific pathologies in a set of human diseases collectively called laminopathies. These are late-onset, tissue-specific degenerative diseases, such as Emery Dreifuss Muscular Dystrophy (EDMD). While rare, these conditions provide insight into more common degenerative disorders linked to aging. A Caennorhabditis elegans mutant that recreates the EDMD phenotypes arises from introduction of a specific gain-of-function mutation into lamin (LMN-1 Y59C), which in turn affects the subnuclear distribution of muscle-specific promoters. This proposal plans to identify novel factors that establish and/or maintain the 3D organization of the genome in differentiated nuclei and to determine how this contributes to the differentiated muscle cell fate. I propose that compromised or altered sequestration of chromatin at the nuclear envelope alters cell-type specific promoter induction and in turn compromises the integrity of the tissue in question. The specific aims of the project are 1) To identify factors that establish and/or maintain 3D genome organization in muscle nuclei. 2) To determine if the integrity of the perinuclear chromatin binding machinery helps maintain differentiated cell states. 3) To test inhibitors of epigenetic regulators for compounds that overcome the EDMD-like LMN-1 Y59C mutation. I will take two complementary approaches to determine how muscle specific chromatin organization maintains tissue integrity. I will use in vivo biochemical tagging in the LMN-1 Y59C mutant to identify perinuclear components that mediate sequestration of muscle-specific gene promoters. In parallel, a drug screen will find compounds that reverse the nuclear disorganization linked to the EDMD-like phenotype. The pathways identified will explain how lamin-induced mis-organization of the genome influences muscle integrity, a topic relevant for muscular dystrophies, sarcopenia, and other degenerative disease.

Mots clés : genome organization, heterochromatin, lamina, nuclear envelope, epigenetics, laminopathies, emery  dreifuss muscular dystrophy, edmd, muscle, gene regulation

Participants :
- Friedrich Miescher Institute (Suisse) — Coordinator, beneficiary, Recherche, subvention : 187419.6 €
Projet CRYSTALCLOCK (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The low-energy excited state of the Thorium-229 (229Th) nucleus has fascinated researchers for decades. With excitation energy of only a few eV, it is the only known nuclear isomeric state accessible to laser manipulation. This system opens up many novel applications, ranging from tests of variations of the fundamental constants to technological implementations as a nuclear clock. While the exact excitation energy of the 229Th isomer remains unknown, significant progress has been made in constraining its energy in recent months. Most importantly, all recent results place the energy between 7.5 eV to 8.5 eV. This is within the transmission band of large-band-gap VUV materials such as single fluoride crystals. It becomes hence possible to embed 229Th inside a solid-state crystal and address a large number of nuclei. This project aims to develop a readout scheme for a solid-state nuclear clock based on nuclear quadrupole resonance spectroscopy (NQRS). The interaction of the nuclear quadrupole moment with the electric field gradient of the crystal causes the splitting of the nuclear states. NQRS can be used for non-destructive readout of the nuclear state during clock operation. Moreover, the NQRS will provide valuable information about the microscopic structure of 229Th atoms doped into the crystal lattice.

Mots clés : nuclear spectroscopy, density functional theory, atomic clocks, frequency standards, fundamental constants

Participants :
- TU Wien (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 186167.04 €
Projet ViGOTHIC (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The main aim of the proposal is to establish a point of reference for the analysis of Visigothic script, the primary carrier of Latin writing in the Iberian Peninsula from the 8th to the 14th centuries. To date, most palaeographical analysis of Visigothic script has been conducted using a traditional methodology and following heterogeneous criteria, which has led to subjective results difficult to share or evaluate. In contrast, my research will create a computerised database of quantitative data by applying a specially designed method, a starting point that will allow codices written in Visigothic script to be described, compared and placed in their socio-cultural context. Innovative techniques for digital analysis of manuscript sources that will be acquired in the host institution will allow me to gain new insights into the analysis of the script while opening new avenues of research by applying digital tools to its study. The knowledge thus generated will be of great practical importance for future palaeographical and textual research establishing criteria upon which advanced studies can build. It will offer a means of understanding the script, its manuscripts, and its cultural context. The study builds on the systematic analysis of one of the few codices written in this script that can be dated and geographically located with certainty: the copy of the Apocalypse of Beatus of Liébana kept at the British Library (Add. 11695). I aim to achieve six specific objectives: A) Manual palaeographical study: (1) to determine how many scribes intervened in the copy of the codex, their graphic characteristics, (2) evolution, and (3) cultural context. B) Digital palaeographical study: (4) to apply and evaluate computer-assisted techniques to the study of Visigothic script, (5) their viability and benefits, (6) to establish a point of reference for computerised analysis of Visigothic script codices by providing accurate graphic foundations to foster historical research.

Mots clés : medieval palaeography, visigothic script, british library, codices, digital analysis

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet NAVSCIN (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The main goal of NAVSCIN is to develop an improved strategy to mitigate scintillation –a particular type of space weather perturbation– tailored for satellite-based navigation techniques, in close collaboration with users and manufacturers of these technologies. Indeed, once the scintillation effect is correctly detected and mitigated, the availability and accuracy of the five billion devices using Global Navigation Satellite Systems around the world, will dramatically improve. The project implements a set of coordinated actions among its different partners that maximize international collaboration between universities, research centres and industry, in different European and Asian countries: First, NAVSCIN will improve the understanding regarding the physical processes resulting in the formation of scintillation, and consequently to identify the drivers in the interplanetary medium, the magnetosphere and the atmosphere. Second, the impact of scintillation on space-based navigation users will be characterised: mainly Ground and Aircraft Based Augmentation Systems (SBAS, GBAS) and high-accuracy navigation techniques (Precise Point Positioning). Third, a set of NAVSCIN algorithms will be developed suitable to support, for the first time, the real-time identification, correction and/or mitigation of scintillation in GNSS receivers. Finally, NAVSCIN will work systematically with potential users to assess the functionality, reliability and efficiency of the proposed solution, paving the way to its systematic exploitation and to its sustainable operation. Overall, the European competitiveness will be potentiated throughout the project with the exploitation of the research results, ultimately giving high-level EU employment and maintaining the European status quo of high‐level‐knowledge countries.

Mots clés : global navigation satellite navigation  gnss, precise point positioning  ppp, ionosphere modeling, scintillation, space weather, ground based augmentation systems  gbas

Participants :
- Universitat Politècnica de Catalunya (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185288.4 €
- Hanoi University of Science and Technology (Viêt Nam) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet beSCIENCEd (Horizon 2020, appel à projets 2016)
Action : European Researchers' Night
Statut du projet : CLOSED

The main goal of beSCIENCEd is to bring the general public and especially young people closer to the exciting world of research and to show that science is fun and accessible for everyone. Scientists from almost all significant research institutions in Vienna are going to participate in the event and present their recent research results in order to generate enthusiasm among young people for science and research. A focus is laid on the fields science, technology, engineering and mathematics (STEM) and the exiting topics cover informatics, mobility, energy, construction, biology, chemistry, mathematics, and automation. Thus, it is shown how broad research can be. Every topic can and will be looked at and interpreted in a different ways and our program is going to cover all these aspects. The beSCIENCEd program will integrate researcher talks, hands-on workshops as well as a range of ongoing activities by the exhibitors and social activities like science cafes where visitors can get in direct touch with scientists and their research. To increase the interest of more young people in research careers, also the opportunities of research during the school time will be shown by the presented projects of the Austrian Sparkling Science initiative as well as by the projects of student researchers active in various research projects. Moreover, to encourage entrepreneurial thinking of young people, a few Viennese innovative start-up companies are going to present their innovation and business cases. To grasp technology with own hands, a series of workshops is provided for different age groups. The social events are aimed at showing that researchers are ordinary people with extraordinary jobs and that research is also much about communication and international cooperation. As the events will take place in Vienna’s biggest high school with approximately 2800 students, science comes directly to the young people. Become a part of science, beSCIENCEd!

Mots clés : science fair, researcher, workshop, science slam, exhibition, talks, science cafe, school, young people

Participants :
- Practical Robotics Institute Austria (Autriche) — Coordinator, beneficiary, Recherche, subvention : 153811.25 €
Projet NeuPES (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The main objective of NeuPES is to advance our understanding of the effect of electrical stimulation (ES) on neural plasticity using nanostructured electrodes. The motivation is to develop an effective therapeutic approach that minimizes neural damage and enhances recovery following brain ischemia. Stroke is a second leading cause of disability in Europe. Moreover, stroke treatment does not have a clear clinical pathway with a predictable end point. Acute strokes are treated within a narrow window of time after the ischemic insult by means of endovascular therapies. After the acute period, intensive physical rehabilitation of the affected anatomical region is the primary current therapy. ES of the brain for therapeutic purposes was established more than 50 years ago, and it constitutes a smart approach for inducing neural recovery after stroke. However, there are still large knowledge gaps about the electrode material/design, effective ES regimes, and the underlying mechanisms by which ES triggers different pathways to induce neural plasticity. This project will address these important challenges by bringing together a multidisciplinary team that includes experts in nano-material science, biomedical engineering and neuronal biology. We propose three objectives: (i) fabrication of nano-structured electrodes that maximize the charge injection capacity by increasing the surface area and improve the biocompatibility; (ii) integration of these electrodes to the electro-bioreactor, an in vitro ES setup recently developed by the Researcher with great flexibility to apply different patterns of electrical signals; (iii) use of the electro-bioreactor to explore the effects of different ES regimes on neural plasticity and recovery and investigate the underlying mechanisms to optimize the ES parameters. The multidisciplinary skills acquired during the project will significantly enhance the future career prospects of the Applicant.

Mots clés : neural plasticity, electrical stimulation, nano structured electrodes, electro bioreactor, astrocytes

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €
Projet REP-EAT (Horizon 2020, appel à projets 2015)
Action : Cofund Doctoral programme
Statut du projet : CLOSED

The main objective of REP-EAT is to build up a new and innovative research and training doctoral programme (DP) in the interdisciplinary domain of food and healthy diet to deepen the impact of food quality on reproductive Health (REP) and eating disorders (EAT). In compliance with the concept of “One Health”, REP-EAT DP will focus on the effect of diet determinants on both humans and animals thus implying a strict integration amongst food and life science research advances. REP-EAT is aimed at training a new generation of creative, entrepreneurial and innovative Early-Stage Researchers (ESRs). The DP will rely on the joint efforts of qualified tutors involved in three pre-existing doctoral courses in Biotechnology, Food Science and Veterinary Medicine of the beneficiary institution, UniTE. REP-EAT is further strengthened by the partnership (9 EU and 2 USA academic and 23 EU non-academic partners) with qualified complementary groups that have fruitfully interacted in previous successful training and research programmes of UniTE. ESRs can undertake an independent and personalized training and research career development plans to be awarded a European double PhD degree from European University partners. ESRs will be exposed to research and entrepreneurial sectors in each phase of the DP (from selection to mentoring, training, research secondment and dissemination activities) to achieve a wide set of technical and transferable skills required to convert knowledge and ideas into products and services for economic and social benefit, to build up their future career perspectives. The regional authority, Abruzzo Region, will provide cofunding support consistently with the regional Smart Specialization Strategy (RIS3) using ESIF funds, in order to foster the development of qualified human resources in Agro-food area, a leading sector of regional economy in needs of continuous innovation in order to compete in the global market.

Mots clés : food, environment, quality, genomic, fertility, reproduction and eating disorders

Participants :
- University of Teramo (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 941760.0 €
Projet SPicEs (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The main objective of SPicEs is to prepare the ER for an independent career in the research sector, by training him within the framework of a high-quality research project at the interface between the science and engineering of materials, chemistry and physics. The scientific objective of SPicEs is the development of a general approach to organize nano-structured materials on the interfaces of liquids, as in Pickering Emulsions, to yield stimuli-responsive devices. The assembly of nanomaterials into components and devices is a requisite to develop marketable applications. Pickering emulsions are an emerging technology with great potential in this field, however many aspects of interest remain to be studied, such as the combination of different materials in a single supracolloidal structure. Within SPicEs, microfluidic methods will be used to generate droplets with a high degree of control, covering them with functional nanoparticles capable of imparting each droplet with useful properties such as the ability to respond to external stimuli (light, heat, pH changes). The emulsions prepared in this way will be used in proof-of-principle applications, as random lasing matrixes and carriers for the controlled delivery of chemical payloads. The project will provide the ER a possibility to train and put his abilities to test on an international level. For him, it will represent a strong starting point for an independent career in research. His training will encompass fundamental and applied science, as well as manuscript preparation, IPR issues, networking and soft skills such as leadership, communication and teamwork in a multi-ethnical, highly multidisciplinary group. For the host institution this project will represent a possibility to broaden the horizon of one of its most distinctive fields of research, that of self-assembly, and strengthen its link with the material science community, by developing fundamental science with a strong potential for practical application

Mots clés : emulsions, supracolloidal systems, microfluidics

Participants :
- Université de Strasbourg (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet QuPhon (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The main objective of the QuPhon research action is to develop a novel hybrid quantum system between a mechanical oscillator and a superconducting qubit, especially focusing on the generation of nonclassical multi-phonon states in an ultra high-Q mechanical oscillator. The challenging task will be realized by utilizing itinerant microwave photons transferring nonclassical states in a microwave memory cavity to a mechanical oscillator. The architecture of connecting spatially separated quantum modules that function differently enables one to exploit their complementary advantages simultaneously. The achievements will bridge independently-developed quantum technologies between electromechanics and circuit quantum electrodynamics, which will lead to further quantum applications, such as quantum memory and quantum transducer with hardware-efficient quantum error corrections, as well as studies on quantum coherence between two macroscopically distinct states in a massive object.

Mots clés : cavity electromechanics, circuit quantum electrodynamics, multi phonon states, and quantum state transfer

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203149.44 €