Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet IMPACT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Ischemic stroke is the second cause of death worldwide. Recombinant tissue plasminogen activator (rtPA) is the only approved therapeutic agent. However, stroke patients often suffer from hemorrhages caused by oxidative stress, leading to high immobility rates. The project conducted at Université Paris Cité is at the cross-section of material science and nanomedicine. It aims to develop a nanomedicine for clot targeting, dissolution, and antioxidant therapy to treat ischemic stroke against oxidative stress. Combining the robust antioxidant activity of the cerium oxide nanoparticles (CeNPs) with the clinical-proven rtPA as a delivery vector, the novel nanomedicine will find its potential application for the care of stroke patients and beyond. CeNPs will be optimized to achieve the maximum antioxidant activity. It will be assembled with polymers and rtPA to preserve circulation time and delivery efficiency. The nanoassembly will be evaluated against oxidative stress and clot dissolution efficiency. The project combines the Researcher's experiences in developing advanced nanomaterials and the hosts' expertise in translating nanomaterials from synthesis to preclinical studies. The project targets treating non-communicable diseases, relevant to the Health pillar of the Horizon Europe programme and the emphasis on developing Advanced Materials by European Commission. It shows a great impact in helping people suffering from the high risks of already approved medication. The project will enable the Researcher to acquire professional maturity related to nanomedicine development. The dissemination of results producing multiple publications in peer-reviewed journals, talks at scientific meetings, and outreach to the general public about the development of the novel antioxidant-related stroke treatment is very probable with the completion of this project. It also creates a potential platform for the scaling process of nanomedicine through collaboration with industrial partners.

Mots clés : nanomedicine, ischemic stroke, thrombolysis, drug delivery, nanoparticles, cerium oxide, single atom catalysis, rtpa, reactive oxygen species, antioxidant, advanced materials, clot dissolution

Participants :
- Université Paris Cité (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet POSTURE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Postures and movements are relevant for both a linguistic and a socio-anthropological investigation. From a cross-linguistic perspective, verbs of posture and motion show several interesting idiomatic and metaphorical usages, and can be employed to express abstract concepts (e.g., psychological states) and grammatical aspects (e.g., urgency or gradual progression of an action). From a socio-anthropological perspective, posture and body language can express real or assumed power relationships and hierarchies, and serve as “externalizers” of status, gender, age, and physical weakness. They establish, express, and maintain group identity; and they indicate friendship and respect or, on the contrary, hostility and self-protection. POSTURE investigates the theme of bodily attitudes, postures and movements within one of the most important pieces of cultural heritage, the Old Testament (OT). Furthermore, it also investigates the reception of Biblical postures and motions within cultural and intellectual products that depend on the OT, either directly or indirectly, i.e., ancient translations (Aramaic, Syriac, Greek and Latin) and Late Antique Jewish and Christian exegesis (1st-3rd c. CE).  Descriptions of bodily postures and motions are very recurrent in the OT, both literally and metaphorically. However, as of today, not enough attention has been paid to this topic. Combining the semantic analysis of posture and motion verbs with their anthropological and social implications will allow to gain new knowledge about the idea of body in the OT. Moreover, the analysis of reception in early exegetical Jewish and Christian contexts will shed some light on the development of the meaning of body and bodily attitudes, through centuries of translations and theological interpretations, from ancient times to present days.

Mots clés : posture and movement, old testament, semantics, classical hebrew, other biblical languages greek, latin, syriac, aramaic , ancient biblical versions, jewish and christian exegesis

Participants :
- Université Louis-et-Maximilien de Munich (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Rome « La Sapienza » (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 266152.49 €
- Pontifical Biblical Institute (Vatican) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MOLOR (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The aim of MOLOR—Morphologically Linked Old Irish Resource—is to make Old Irish distributed lexical resources interact by using state-of-the-art data models and lexicographic standards based on the Linguistic Linked Open Data (LLOD) principles. On the basis of the 8th-century Old Irish Würzburg glosses, MOLOR will fully exploit a set of existing (both textual and lexical) resources by linking the text with a full-form lexicon containing both normalised and variant spellings as well as phonological representations. The integration of resources will benefit many different stakeholders, including lexicographers, philologists, and students, who currently work with inadequate and fragmented resources for a language with a highly complex morphology and an inconsistent and opaque orthography. Thanks to the internationally recognised expertise of the host institution, the applicant will be at the forefront of developments in LLOD and language processing for ancient languages. As a result of the envisaged mutual knowledge transfer, MOLOR is not only expected to lead to a novel standard in resource creation and interlinking for Old Irish, but it will also substantially contribute to and improve language-independent lexicographic data formats and ontologies, as such being applicable to any language and any domain. Finally, the fellowship will significantly improve the applicant’s skillset and employability due to increased interdisciplinary expertise at the intersection of the Humanities and Technology, and the fostering of new partnerships on resource creation and streamlining for ancient Indo-European languages.

Mots clés : old irish, linguistic linked open data, linguistic resources, morphology, inflected lexicons

Participants :
- université catholique du Sacré-Cœur (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet SEMENSUF (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

SEMENSUF is an interdisciplinary and collaborative project at the crossroads of philology, intellectual history, and material culture that adopts basic tools of digital humanities for Arabic literary and religious studies. It aims at providing an open-access scholarly edition and lucid, knowledge-sharing English annotated translation of the oldest extant encyclopaedia of Islamic Mysticism, the Book of Flashes in Sufism by Abū Nasr al-Sarrāj (d. 988). Through its innovative method, SEMENSUF aims at laying the foundations for a new historical and textual approach to the editing of early Sufi sources: the philological atomization of the work in textual units, the study of the manuscript transmission and material culture, and the digitization of later related sources are critical for shedding light on channels of knowledge transmission, centers of learning, and scholarly networks in early Sufism and more broadly in Islamic culture. SEMENSUF strongly believes that editing and translating a 1000-year-old work of mysticism can have a major impact on European multicultural and multifaith societies. In fact, the Book of Flashes tackles several intra- and extra Islamic issues that are still very much relevant to today’s Europe: it highlights how mysticism is and should be considered a genuinely component of Islam, invalidating most contemporary Neo-Salafi claims to the contrary; more importantly, the Book of Flashes reflects a strong concern for and appraisal of heterogeneity and pluralism within Islam. It is a hymn to diversity and to coexistence of different practices and sensibilities which collaborate rather than compete, resulting in a shared spirituality. SEMENSUF thus aims at having an impact on European pluralistic society by making available, to a wide audience, a universal text which will stimulate a reflection on mysticism as a safe space for intercultural and interfaith pluralism, dialogue, and inclusivity.

Mots clés : premodern arabic literature sufism islamic mysticism islamic studies arabic codicology material culture intellectual history, digital humanities

Participants :
- University of California System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de New York (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- université catholique du Sacré-Cœur (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 254979.84 €
Projet quasi-SANTE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Worshipped, contested, abandoned. This downward spiral marked the fates of dozens of mystics and aspiring saints who lived in Italy in the first half of the twentieth century. Neglected today by the majority of the faithful, condemned by the ecclesiastical authorities and ignored by scholars, the memory of these figures risks falling into the haze of history and, with it, also the devotional practices and popular cults developed around them. By forgetting them, we are renouncing any understanding of a significant part of the lived religion of the recent past, as well as ignoring the heterogeneous dimension of venerations shaped ‘from below’ (vox populi) and the importance of minority and marginalised groups (such as emulators of holiness) in contemporary Catholicism. Following this path means flattening research to the dominant narrative (vox cleri) and feeding the main historiographical mainstreams based on the top-down perspective (officially approved saints and politicised cults). Against this scenario, ‘Mystical Italy. The contested side of holiness’ (quasi-SANTE) aims to go beyond the institutional and formal approach to the religion to focus on the popular and potentially contested dimension of holiness through the analysis of aspiring saints who, during their lifetime, attracted veneration and suspicion and catalysed public attention. Through quasi-SANTE, we will get innovative insights into (1) the ‘ordinary people’s’ perception of holiness; (2) the features that mystics had to embody or the skills they had to display to gain the social reputation of ‘living saints’; (3) the devotions judged problematic for the clergy; (4) and how the media, science, and authorities (religious, civil and medical) fit into these dynamics, supporting or opposing them. Quasi-SANTE will develop scientific articles, international workshops, a database on contested holiness, social and multimedia content, and an exhibition aimed at the scientific community and a wider audience.

Mots clés : contested holiness sanctity mysticism catholicism contemporary italy lived religion religious studies history of religion religious anthropology ethnography women studies

Participants :
- université catholique du Sacré-Cœur (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet SMiPAX4 (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The following project, SMiPAX4, conducted in the academic group of Jean-Philippe Herbeuval (Univeristy of Paris, France), is at the cross section of immunology and pharmacology. Moreover, due to its direct application potential and the subsequent industrial placement to deepen the acquired knowledge at Sanofi it is also cross sectional between academia and industry. The main objective of the project is to understand the mode of action of small molecules, functionally causing a reduction of immune response, binding into the minor binding pocket of the G protein coupled receptor CXCR4. The signalling cascade as well as the implication of different expression levels of the target CXCR4 will be explored through different biochemical techniques. Protein-protein interactions will be identified using Bioluminescence energy transfer (BRET) techniques, increase or decrease of second messenger molecules will be identified using biosensors, and phosphorylation states, up- or downregulation of (signalling) proteins will be measured using flow cytometry or western blotting. Inflammation of cells when controlling the impact of silencing certain signalling molecules will be controlled by measuring the levels of inflammation markers. Due to the projects implication in (auto)immune and other inflammation diseases it is relevant for cluster 1, Health, of the Horizon Europe programme. The project shows great potential in the area of impact due to its unique target potentially helping people that do not respond well to already approved medication. Both, the dissemination of results producing multiple publications in peer reviewed journals, talks and posters at scientific meetings as well as the potential of creating market within the EU are very probable with completion of this project.

Mots clés : gpcr g protein coupled receptor , bret bioluminescence resonance energy transfer

Participants :
- Sanofi-aventis R&D (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Paris Cité (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 244893.6 €
Projet NeuroSquam (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

In the absence of brain tissues preserved in the fossil record, vertebrate endocasts provide the only ‘direct’ evidence of brain evolution through deep time, and the possibility to infer cognitive and sensory abilities of extinct taxa. However, the validity of paleoneurological studies critically depends on the reliability of endocasts as a proxy for brain morphology. The variable brain-endocast correspondences found between and within modern vertebrate lineages prevent any generalizations to date. A detailed understanding of brain-endocast relationships in extant vertebrates is thus extremely important in order to avoid erroneous interpretations based on endocast morphology alone. NeuroSquam aims to study the brain-endocast relationships in the clade of Squamata, including lizards and snakes. Despite previous studies reporting a wide range of brain versus endocranial cavity proportions in lizards, our understanding of squamate brain-endocast relationships remains limited. By combining 3D imaging and 3D geometric morphometrics on a wide range of species, this research will provide a detailed and updated assessment of the brain-endocast relationships in Squamata. I will explore how these relationships vary between and within species in order to understand the different eco-biological factors that may impact the correspondence between brain and endocast. In addition, the comparison of morphometric data obtained from different 3D imaging techniques will provide new insights into the impact of fixation and staining on tissue shrinkage. By identifying reliable tissue-specific correction factors to adjust for shrinkage, this project will provide a starting point for future neuroanatomical studies seeking to use data from different imaging protocols. NeuroSquam’s originality and interdisciplinary nature will generate exceptional datasets and high-profile outputs and establish the applicant as an innovative leader in functional and comparative (paleo) neuroanatomy.

Mots clés : squamate, brain, endocast, neuroanatomy, brain endocast relationships, 3d imaging

Participants :
- Muséum national d'histoire naturelle (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet QSun (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Quantum information processing is a transformative technology that will address societal needs by obtaining unprecedented computational power with quantum computers and simulators, unconditionally secure quantum communications, and quantum-enhanced sensors. Photons play a central role in the development of quantum technologies due to their unique capability to encode quantum information with low-noise, transmit it over long distances, and process it in scalable photonic circuits. However, the lack of photon-photon nonlinearities poses a central challenge in the development of photonic quantum technologies. The aim of this proposal is to address this limitation for next-generation quantum photonic devices. The enabling technology is the combination of two quantum photonic platforms: light-matter interactions with quantum dot emitters in integrated nanostructures, and programmable quantum photonic circuits performing universal transformation in the temporal degree of freedom. Through the use of high-quality light-matter interfaces and efficient interconnection with photonic circuitry, this project will (1) develop devices able to perform high-quality programmable nonlinear circuits, and (2) demonstrate how such devices can be used to implement near-term applications, focusing on the quantum simulation of anharmonic molecular dynamics. The developed platform solves a critical set of challenges that have limited the scaling of quantum photonic devices, enabling transformative quantum photonic technologies for quantum computing and networking. The synergy between my strong experience in programmable quantum photonic devices and applications, the world-leading expertise of Prof. Lodahl’s host group in integrated light-matter interactions, and the high interdisciplinarity of the Niels Bohr Institute and University of Copenhagen, makes us uniquely placed to execute this ambitious project.

Mots clés : quantum photonics, solid state emitters, quantum simulation, quantum computing

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet TIRECUA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Traditional foodways: Innovation, REsilience and ContinUity in the Ancient Mexican Highlands (TIRECUA) aims at reconstructing the diet of ancient Mesoamerican populations from the Western Mexican Highlands. Food is a highly multidimensional character which not only translates the necessity of eating but also fundamental cultural processes, subsistence practices and environmental constraints. Today, our food practices have an increasing impact on human health and on the environment, and the rediscovery of more traditional eating habits has the potential of reducing our environmental footprint, increasing global health and improving the future of food security. This research will focus on Mesoamerica, a region traditionally relying on an original and economically important set of food products but where Indigenous knowledge is seldomly recognised. TIRECUA will develop an innovative multidisciplinary approach to understand what food was consumed by whom, and how it varied through time. This EU-funded research project will set-up a state-of-the-art framework for biomolecular diet analyses including stable isotopes, palaeoproteomics and ancient DNA by combining the skills of the applicant with the host institution. The outcomes of TIRECUA are expected to be of interest to a large public by highlighting ancestral recipes, acknowledging the cultural origin of this food in the deep-time and promoting alternative, healthy and sustainable meals.

Mots clés : mesoamerica molecular archaeology stable isotopes weaning proteomics ancient dna diet reconstruction

Participants :
- Université de Bordeaux (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
- Muséum national d'histoire naturelle (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet INSIGHT-LV (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

INSIGHT-LV aims to improve cardiovascular risk prediction by enhancing the evaluation of left ventricle function using multimodal methods. Heart failure (HF) affects over 26 million people globally, with high healthcare costs and hospitalization rates. Current diagnostic tools often fail to accurately predict adverse events, highlighting the need for more effective risk prediction models that integrate diverse clinical data.  INSIGHT-LV focuses on two high-risk HF groups: hypertrophic cardiomyopathy (HCM) and COVID-19 patients. HCM, a major cause of sudden cardiac death in young people, lacks updated guidelines and relies on limited predictors. COVID-19 patients show significant cardiovascular risks, creating an urgent need for better risk stratification tools. These two groups represent a substantial part of the HF population requiring improved stratification.  The project will provide clinicians with tools to deliver optimized, cost-effective treatment strategies. By characterizing and stratifying HCM and COVID-19 patients, INSIGHT-LV aims to personalize decision-making and advance disease understanding. Using computational modeling, AI, machine learning, and advanced signal and image processing, the project will integrate multimodal datasets, including ECGs, MRIs, genetic tests, and echocardiography, ensuring robust clinical solutions.  INSIGHT-LV will test AI models on real-world data to validate improvements in predicting risks such as sudden cardiac death and arrhythmias. This work will set new standards for cardiovascular diagnostics, delivering scientific, societal, and economic benefits.

Mots clés : cardiovascular risk quantification, digital biomarkers, artificial intelligence in medicine, machine learning, in silico models, hypertrophic cardiomyopathy, covid 19

Participants :
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €