Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet TRIALOGUES (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

TRIALOGUES is an interdisciplinary research project on emerging biopolitics of kinship, gender, and reproduction. It focuses on path-breaking processes of legal innovation and concomitant political backlashes taking place in Brazil, Spain and Portugal in order to offer a singular comparative approach and to provide empirically informed theoretical insights that are relevant for ongoing debates in the intersections among gender and queer studies. Rooted in the field-defining works of moral and political philosophers, recent feminist scholarship and queer theorists have shown the need for interdisciplinary approaches to biopolitical studies. Drawing in this dense intersection between social sciences and the humanities, the proposed research focuses in three countries pertaining to the European and the global south whose recent history is marked by the transition to democratic regimes in which profound transformations of the biopolitics of kinship, gender and reproduction took place over a rather brief period of time. In this sense, the proposed research constitutes an original response to influent criticisms coming from sexuality studies urging a de-centering of the academic focus away from the global north in order to retain the very political impulse of field-defining concepts such as sexual and intimate citizenship. More specifically, the project comprises one main strand to be conducted in Brazil –the country of primary focus– and 2 complementary strands in Spain and Portugal, where research will be enabled through secondments. All three strands are aimed at producing empirically informed discussions of emerging biopolitics with an emphasis in the state logics (e.g. political institutions, social policies, legislative and judicial provisions) involved in the overlapping fields of kinship, gender and reproduction as they unfold through emerging regulations of non-monogamous relationships, gender identity and third-party assisted reproduction.

Mots clés : biopolitics, feminist and queer bioethics, non monogamies, gender identity, gestational surrogacy, conservative backlash, public order, global south, southern europe

Participants :
- Federal University of Bahia (Brésil) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Coimbra (Portugal) — Coordinator, beneficiary, Recherche, subvention : 237768.0 €
Projet LiveDeadFossil (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Taphonomy is the interdisciplinary science, between the fields of biology and geology, that evaluates the transition of live organisms into death assemblages and, eventually, into fossil remains. Modern death assemblages provide a basis for understanding what components of living communities may be preserved in the fossil record and what biases are to be expected. Also, methods and discoveries of taphonomic research in modern ecosystems are of value to ecologists because skeletal remains hold a wealth of information about the vertebrate species inhabiting an ecosystem. Despite the interdisciplinary information that these studies contain, naturally occurring bone accumulations are largely unexplored and have not been studied neither in the European realm nor in a Mediterranean ecosystem. We propose here a training-through-research project based on the taphonomic monitoring and fidelity evaluation of the vertebrate death assemblage (mainly >5 kg terrestrial vertebrates) of a UNESCO World Heritage Site, Doñana National Park (DNP) (Spain). The candidate has experience in the taphonomic reconstruction of fossil sites but has limited exposure to taphonomic field techniques and analyses of modern death assemblages and live:dead fidelity studies. The LiveDeadFossil project will broaden her professional experience and contribute to her growth as independent researcher. The research will shed light on the ecological and post-mortem processes undergone by vertebrate remains in a Mediterranean ecosystem and will complement the study and management of the vertebrate communities of the park. The selected host organization, Doñana Biological Station-CSIC (Seville, Spain), is a world-class research center for ecology and conservation biology, manages all the activities at DNP and has all the facilities and services in place (including population census data, osteological collections, laboratories, etc.) for the successful fulfilment of this training and research programme.

Mots clés : taphonomy, live dead fidelity, death assemblage, vertebrates, mediterranean ecosystems

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €
Projet USP2-TD (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Targeting DUB enzymes has recently emerged as a promising opportunity for drug discovery that might lead to more selective, less toxic drug profiles. Target validation of these enzymes is currently a priority in the field, as we are lacking of appropriate chemical probes for most of them. A clear example is USP2, whose chemical inhibition has been barely explored, leading to a poor-quality chemical probe that has been extensively used by biologist during the last decade. Hence, this multidisciplinary project emerges to address the identified unmet need of providing the scientific community with an appropriate chemical probe for a confident interrogation and further understanding of USP2 biology and disease. This probe will be useful for a suitable validation of this promising target and can eventually feed drug discovery projects for USP2-related cancer treatments. Herein, we aim to develop a, USP2-Targeted Degrader (USP2-TD) that overcomes the lack of selectivity and potency of its parent counterpart. This small-molecule USP2-TD will enable investigations of selective USP2 downregulation with exquisite quantitative and temporal control of protein levels. To this end, the proposed research deal with the identification of solvent-exposed region at the parent, the discovery of the USP2-TD, and its validation as chemical probe for USP2.

Mots clés : deubiquitinases, ubiquitin specific protease 2, challenging protein targets, biophysics, chemical biology, chemical probe, targeted protein degradation, protacs, drug discovery

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet 7DUP (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Technological advances have allowed the identification of multiple rare rearrangements caused by structural and copy number variants (CNVs). The 7q11.23 microduplication syndrome (7dup) and Williams-Beuren (WBS) syndromes are originated by genomic reciprocal rearrangements that result in opposite phenotypic features in the area of communication and sociability. Although WBS has been extensively studied, there is lack of exhaustive studies of 7dup at the clinical and molecular levels. In this project, we aim to compile and characterize a large group of 7dup patients. Moreover, we will actively collaborate with a recently created 7dup support group. Little is known about the functional mechanisms disrupted by these aneusomy syndromes and the specific alterations caused during brain development. Limitations in the available animal models, lack of quantitative data and limited computational capabilities have precluded the identification of relevant molecular pathways involved in these disorders. This proposal aims to overcome these limitations by applying an integrative multidisciplinary approach involving experimental and computational methods. To generate human neuronal in vitro models, somatic cells from a defined subset of individuals with 7dup and WBS will be reprogrammed to obtain induced pluripotent stem cells and differentiated to neurons. To define neuron-specific alteration patterns in gene expression caused by these CNVs we will perform transcriptome analyses at multiple differentiation stages. Finally, the expression data will be integrated with protein interaction and other systematic gene annotations datasets to perform omic analyses to identify dysregulated pathways. Our results will help to better characterize at clinical and molecular level the unexplored 7dup disorder; to improve understanding of the functional basis involved in this reciprocal aneusomy syndromes; and to generate a disease model to test and determine appropriate therapeutic targets.

Mots clés : 7q11 23 microduplication syndrome, williams beuren syndrome, copy number variant, human induced pluripotent stem cell, hipsc, rna seq, omics integrative analyses

Participants :
- Pompeu Fabra University (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 158121.6 €
Projet TECHNET (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Technology is one of the most transformative innovations of human kind: it has profoundly impacted economic, social and cultural history. Understanding humans’ capacity to innovate provides fundamental tools for the study of technological advance and human progress. Technology applied to crafts has radically changed the relationship between maker and matter, that is mankind’s ability to manipulate its material environment and transform it into useable objects for living. Stone is the most challenging matter for craftsmen to process since it requires a complex series of technological choices and an articulate operational sequence. Consequently, stone vases, as objects made of stone, represent crucial analytical “tools” to investigate technological innovation in ancient crafts. Disclosing the processes and circumstances of transformative innovations in the ancient world helps us comprehend the mechanisms of modern technology and its role in shaping contemporary and future societies. Much ground-breaking research has shown that Protohistoric stone vessel production involved significant technological input and knowledge transfer, thus playing a key role in the development of Prehistoric Mediterranean craft traditions. Similar research for the Classical period is still lacking. With the TECHNET action I put forward an innovative, multidisciplinary approach to the development of technology in ancient crafts using Greco-Roman stone vases as case study. My starting hypothesis is that Greco-Roman stone vases have the potential to inform us on technological development, knowledge transfer and materiality practices in the Classical period. I intend to test this hypothesis through the combination of ethno-anthropological and sociological qualitative analysis with computer informed data processing. Undertaking such a research at ICAC is set to offer novel scientific tools to the history of manufacturing technology and to bolster my scientific profile.

Mots clés : ancient stone working, materiality practices, gender and identity status, lathe turning, skeuomorphism

Participants :
- Institut Català d'Arqueologia Clàssica (Espagne) — Coordinator, beneficiary, Recherche, subvention : 172932.48 €
Projet G4invivo (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Telomeres, the ends of linear eukaryotic chromosomes, are one of the most versatile “molecular machines” of life. They perform a vital role in several fundamental processes in biology, as maintenance of genome integrity and the regulation of cell growth. Human telomeric DNA consists of thousands of tandem repeats of guanine-rich sequences, terminating the chromosomes. Under physiological conditions, such guanine-rich repeats are capable of adopting four stranded structures, called G-quadruplex DNA. Considerable research has been dedicated to an understanding of functions of telomeres, and during the past decades, much progress has been made towards identifying the underlying processes for G-quadruplex DNA isolated in vitro. However, most of our knowledge of conformation and mechanistic understanding of the balance between the structure and function of telomeric DNA inside cells has remained very limited, largely due to a lack of suitable methods. An opportunity to bridge this gap is single-molecule fluorescence microscopy in combination with Förster resonance energy transfer (FRET), a powerful technique that allows distances, distance distributions, and dynamics of individual biological molecules to be measured even in complex and heterogeneous environments, as cellular milieu. The goal of this project is to employ such optical single-molecule techniques to perform a comprehensive biophysical analysis of the folding and dynamics of G-quadruplex DNA within live cells. This investigation will provide an idea of how accurately our current understanding of the folding and dynamics of G-quadruplex DNA in vitro describes the situation inside the living cell, and will, among other aspects, be crucial for understanding the biological functions of G-quadruplexes and in particular may stimulate the enhancement of the efficacy of the novel anticancer therapies, which use these structures as an active target for drug development.

Mots clés : g quadruplex dna, telomeres, folding, dynamics, single molecule microscopy, forster resonance energy transfer  fret, in vivo, molecular crowding

Participants :
- Aarhus University (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet EnterTerra (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Telomeres, the heterochromatic structures that protect the ends of the chromosomes are transcribed into a novel class of long non-coding RNAs whose transcriptional regulation and functions are unknown. Telomeres protect the physical extremities of the chromosomes and they are are essential to genome integrity and stability. Dysfunctional telomeres have been detected in up to 90% of human cancers. We recently found that telomeres are transcribed from the subtelomeric region towards the end of the chromosome into the telomeric repeat-containing RNAs (TERRA). The identification of TERRA introduced a new field of research that demonstrates the structural and functional complexity unfolding at telomeres. Several lines of investigation have failed to elucidate the transcriptional activation network and functions of TERRA. The proposed research is built on a series of unrelated parts to explore the transcriptional requirements and the role of TERRA in the cells, employing a variety of different and revolutionary approaches. We plan to systematically identify the transcriptional factors that bind TERRA promoters and characterize their role in TERRA biogenesis (1). We will explore the dynamics of TERRA localization and determine if the transcripts remain attached to the sequence of origin or they can act at other chromosomal ends or loci (2). And finally we will elucidate the role of TERRA in stabilizing or recruiting telomeric or heterochromatic proteins at both telomeric and non-telomeric loci and assess their function on the chromatin (3). We expect that our innovative approaches will decipher TERRA’s localization preference on the chromatin, explore the multilayered ribonucleoprotein TERRA cluster, and it will provide new insights on plethora of telomere functions. Our studies will have a profound impact on our current understanding of the structural and functional complexity of telomeres.

Mots clés : telomeres, subtelomeres, lncrna, terra, heterochromatin, telomerase, transcription factors, regulation, protein interactions

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175419.6 €
Projet PROTEXPO (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Temporary trade barriers, which include anti-dumping, countervailing duties, and safeguards, are the heart of EU trade policies. While recent literature centers on the issue of the effectiveness of such trade instruments in protecting EU firms and jobs, less attention has been given to their effects on the targeted foreign firms. This is an important omission since temporary trade barriers can affect protecting firms directly but also indirectly, through their effects on targeted firms. Trade restrictions can reduce the volume of the targeted firms' exports to the EU but also they can alter the composition and the quality of their products' portfolio, affecting the extent of market competition for the EU firms. In a world with increasing integrated global supply chains, temporary trade barriers that aim to protect EU firms may indeed bring a negative impact on them. Despite the importance of temporary trade barriers, the ways these trade restrictions shape the targeted firms’ export performance remains poorly understood. The objective of this project is therefore to examine how targeted Chinese firms have restructured their export activities across products and markets in response to the EU temporary trade barriers. To this aim, the work explores three related lines of research: (i) the effect of temporary trade protections on intra-firm adjustment processes, (ii) their influence on firms' product quality; (iii) the relationship between firms' vertical production and trade protection policies. The analysis of how targeted firms respond to such trade restrictions are relevant for policy, in particular in the light of the current heated discussion on whether EU should grant China market economy status. A better understanding of the interconnections between targeted firms’ export adjustments and temporary trade protections is crucial for designing appropriate policy interventions.

Mots clés : multi product firms, temporary trade barriers, product portfolio, product quality, global value chain

Participants :
- University of Trento (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet NIOBE (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : CLOSED

Tests of the Standard Model (SM) of Particle Physics and the search for New Physics (NP) is a central issue in the European program in High-Energy Physics. Weak decays of heavy hadrons have a unique potential for the extraction of SM parameters, the study of CP violation, and the search for NP. Among these, decays of B mesons into three final hadrons are of huge phenomenological interest. They have been studied experimentally at B factories and at the LHC, and will be a cornerstone in the physics program at Belle-II. However, the theoretical basis for such processes has yet not been developed. Through this project, we will establish the theoretical grounds for the description of non-leptonic three-body B decays, from basic principles to phenomenological applications. The theoretical description of three-body decays requires a generalization of the theory of non-leptonic two-body B decays, which is by now well established. It involves factorization of perturbative and non-perturbative physics --most conveniently achieved in the framework of Soft-Collinear Effective Theory (SCET)--, the calculation of perturbative kernels, and the study of non-perturbative matrix elements. However, this generalization is non-trivial and requires addressing new issues and facing new challenges, making this a highly innovative project. We are three the participants in this action: - Javier Virto (Main Researcher), with a wide experience in the theory and phenomenology of B decays, will be the driving force in this project, while receiving an intensive training from two of the developers of the theory of hadronic B decays. - Iain Stewart (US partner), developer of Soft-Collinear Effective Theory. - Martin Beneke (EU Host), developer of the QCD Factorization approach and SCET in position space.

Mots clés : flavor physics, quantum chromodynamics, effective field theory, soft collinear effective theory, beyond the standard model, cp violation

Participants :
- Technical University of Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214828.2 €
- Massachusetts Institute of Technology (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet STREAM (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Textiles evolved around two initial purposes (protection and aesthetic), while the contemporary research focuses on integrating functionality and comfort into the textile products. Using textiles in healthcare applications provides a convenient means for a continuous monitoring of patients with non-obtrusive devices that have an access to all areas of the body. This allows a mapping of physiological parameters over the entire body, leading to innovative products required by two Europe 2020 Strategy Flagship Initiatives. Optical fiber sensors (OFS) offer many advantages over sensors that require electrical conductivity; however, there is an urge to introduce and test new materials that compensate for their shortcomings. This project builds upon (and goes beyond) the current state-of-the-art and introduces effective, yet simple, methods to synergistically tackle three challenges of OFS, namely: sensitivity, distributed sensory, and production technology. A "sensitive cladding" will be developed to allow localized as well as remote responses for external stimulants. This will be achieved by incorporating thermochromes and other functional molecules into the polymeric system. The OFS will be produced using a novel microfluidic device that allows a precise control for fiber's morphology. The developed sensors will be integrated into textiles to monitor skin temperature and alarm against (sub)cutaneous tumors/cancers. The multi-disciplinary nature of this project will diversify my (technical and soft) skills through hands-on as well as through-research trainings. Particularly with the optical performance of fibrous systems, which will ensure establishing myself as an independent researcher in the field of smart wearable devices. Disseminating and exploiting the results of this research will bring long-term benefits and innovative products for many applications beyond the textile field, and it will introduce me to the industrial sector with its new career opportunities.

Mots clés : polymer optical fibers, smart textiles, thermochromic materials, microfluidic wet spinning, distributed temperature sensor

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203149.44 €