Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MIND-CLARITY (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Mental health represents a major worry in most countries while providing a good diagnosis is a hard task. A reliable system for assessing mental disorders is crucial for helping clinicians and patients achieve accurate diagnoses and treatment. Research has long established that certain vocal features are linked to mental health disorders, allowing a machine learning model to learn how to classify different mental disorders using voice. Artificial intelligence (AI) has been providing excellent responses diagnosing mental diseases so far but, remarkably, they often operate as "black boxes" that do not allow for an understanding of how they make their decisions. This makes it mandatory to perform a thorough study on the system in order to achieve fairness, explainability and trustworthiness.  This project aims to develop an open source AI based model, explainable and transparent, that can assess between many mental illnesses using voice recordings from a patient, contributing from the study, analysis and understanding of the problem, providing greater interpretability, security and extrapolation ability. The project will be divided in three stages, curation of dataset, the development of the system and exhaustive explainability and fairness analysis over the system.  This tool does not replace a clinician diagnosis, it intends to help them decide in dubious cases, with non invasive, cheap and easy tests that can be performed with a cell phone by the patient or his/her family to keep a daily control.  This is a multidisciplinary project that combines health sciences, machine learning and mathematical modelling. This project also intends to share expertise with the host organization and equip the candidate with training advanced methodologies. The results could substantially enhance the effectiveness of mental health diagnosing. This project aligns with the EU’s strategy for safeguarding public health.

Mots clés : machine learning ml mental health assessment explainability and transparency speech analysis

Participants :
- Sant Joan de Déu-Barcelona Children’s Hospital (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Saragosse (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209914.56 €
Projet RhythMods (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Neurological diseases, such as Parkinson’s Disease (PD), are the leading cause of disability in the world. The role of brain rhythms has not been completely understood but evidence suggest that specific motor disorders may be linked to abnormal brain oscillations. Researching ways to modulate specific cortical motor rhythms could lead to discovering more effective approaches to treat patients with neurological disorders affecting their motor condition. However, our current understanding tools are insufficient to access and interact with this kind of neural activity. Non-invasive neuromodulation protocols such as transcutaneous Spinal Cord Stimulation (tSCS) are raising interest in recent years to induce changes in the Central Nervous System (CNS) that can lead to functional improvement, while the side effects and applicability limitations of invasive procedures are overcome. Better understanding the interaction between neuromodulation protocols and brain rhythms is crucial for the development of interventions targeting pathological circuits which can favour plastic changes and the restoration of impaired motor functions. In RhytMods, I will develop a non-invasive neuromodulation platform to apply closed-loop stimulation protocols synchronized with brain oscillations decoded from the periphery with muscle recordings (high-density electromyography, HD-EMG). The platform will allow to explore the modulatory effects of brain-oscillations-dependent stimulation of the CNS to treat motor symptoms and its potential to entrain and disrupt neural oscillations linked to motor recovery in patients with PD. This research has the potential to transform our understanding of neurological disorders with pathological brain oscillations and to develop new minimally invasive and cost-effective technologies to treat the motor symptoms in neural disorders.

Mots clés : neural engineering, neurorehabilitation, neuroscience, parkinson s disease, neuromodulation, emg

Participants :
- Université de Saragosse (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet COMMONS (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The aim of this project is to examine how commons-based peer production is impacting healthcare ecosystem dynamics and the lived experience of people with diabetes (PwD). The project focuses on communities of PwD who, collaborating online via open-source forms of knowledge exchange, are increasingly empowered to create and modify diabetes technologies to better meet their medical needs. Since its emergence in 2013, this patient-led commons has produced a range of innovations that can help improve clinical outcomes and quality-of-life. However, these innovations sit outside of commercial and regulatory processes and create dilemmas for healthcare professionals, regulators and industry. Furthermore, the central role of technology in this community has raised questions about who can participate in and benefit from its innovations. Through in-depth interviews and ethnographic observations, this project aims to capture the understandings of key stakeholders as to how and why the patient-led commons came to be as well as their visions of its role in the future of diabetes care. It ill shed light on how patient-led innovation is potentially transforming the development and diffusion of healthcare technologies and the implications of this for equity in healthcare outcomes. It is anticipated that the findings will help decision-makers to determine what sort of collaborations or partnerships can be developed between the patient-led commons and established ecosystem players to address the needs of PwD and other chronic conditions. The project includes a training programme supported by an international team of prominent scholars in science and technology studies and will provide opportunities for learning and networking that will help consolidate the Fellow as an emerging leader in patient-oriented research. Overall, the Fellowship alligns with the EC’s commitment to the inducement, uptake and scaling-up of social innovation in Europe as well as 3,5&8 of the UN SDGs.

Mots clés : patient led innovation, qualitative

Participants :
- University College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269915.04 €
- Capital Region of Denmark (Danemark) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université York (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ECO (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The analysis of lead isotopes in Roman coins has gained significant popularity in recent years. Several ERC-funded projects provide clear evidence of the scientific interest in ancient coins and their isotopic results. Today, lead isotope analysis is the most effective method for establishing the geographical origin of lead present in ancient metals or coins. The project “Echoes of Rome: Deciphering Hispania’s Coinage Origins with Lead Isotope Analysis” is based on this multidisciplinary approach. Despite these advancements, the supply of metals to Roman provincial cities for minting bronze coins remains a mystery, and a holistic view has yet to be addressed. Through the ECO project, I will analyze the provincial bronze coinage of Hispania. Additionally, the lead isotopic results obtained by MC-ICP-MS will be compared. This comparison will provide a solid foundation for future research. The progress achieved in terms of origin, supply, and distribution will be highly regarded by scholars. Furthermore, the combined use of epigraphic and archaeological sources, along with new data provided by isotopic analysis, will enhance our understanding of the economic history of the Roman Empire, particularly Hispania, one of the most prosperous and significant regions of the Mediterranean. Finally, the archaeological and mining context of Hispania and its development are of paramount importance to the Roman Empire. The mining areas of Cartagena-La Unión and Linares-La Carolina were, for decades, Rome’s main source of silver.

Mots clés : numismatics, ancient coins, roman coinage, bronze coins, roman mining, metal supply

Participants :
- Université de Malaga (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 318138.72 €
- Université de Victoria (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet plasticOME (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The gut microbiome (GM) is essential to human health and its dynamics allow for compositional and functional changes, giving it the potential to help hosts to adapt to rapidly changing environments. Although there is growing concern and public pressure to understand the impacts of increased plastic pollution on human health, a detailed assessment of this xenobiotic’s impacts on GMs is a major gap in research that this proposal seeks to bridge. I hypothesize that given (a) human exposure to plastics began very late in human evolution at the turn of the 20th century, (b) this exposure is ever increasing, and (c) preliminary results from my previous research show associations between plastic ingestion and changes in GM diversity and compositions, then plastics likely play a role in shaping GMs and their functions in modern humans. I aim to test this hypothesis by (1) determining the prevalence of plastic-degrading (PD) microbes and functions across modern GMs in order to (2) validate and characterize in vitro a subset of candidate gut microbes’ capacity for previously unidentified PD to finally (3) investigate plastics as a modulator of modern GMs. This will unveil unexplored factors behind the evolution of human gut microbiomes that could lead to the discovery of new plastic degrading microbes relevant for plastic pollution remediation strategies. This project takes an unconventional and multidisciplinary approach by exploiting advances in microbiome research encompassing bioinformatic tools and databases, applying these to the plastics field, and targeting humans. By building on my existing skills in wildlife and microbial ecology and plastics research and expanding them into human and computational metagenomics (strengths of the host), I am confident that plasticOME will enhance my academic profile at the unique crossroad between metagenomics and plastics research, allowing me to grow into an independent group leader.

Mots clés : human gut microbiome, computational metagenomics, metagenomic plasticity, plastics, plastic pollution, xenobiotics, ecology, anthropogenic disturbances

Participants :
- Université de Trente (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet MetaScat (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Recent studies have confirmed that diagnostics based on liquid biopsy with single extracellular vesicle analysis reach sufficient clinical accuracy. The analysis at the single particle level is critical due to their clinically relevant heterogeneity. However, the current standard, fluorescence-based imaging platforms, cannot be scaled and require complex sample preparation. To provide a label-free and scalable alternative to fluorescence-based microscopy for single extracellular vesicle analysis in liquid biopsy, this project will lead to the development of a metasurface-based integrated imaging platform that controls the image-contrast via nanophotonic resonances (MetaScat). The hypothesis is that MetaScat will enable the label-free detection of tiny refractive index changes induced by the binding of specific antibodies to the membranes of extracellular vesicles and extract information about their single-particle biomarker distributions with a low-cost, compact imaging device. Interferometric scattering microscopy (iScat) could provide the required sensitivity. However, conventional iScat relies on high numerical aperture objectives, inherently cannot be scaled, and is restricted to a small field of view. To overcome these limitations and enable the combination of high sensitivity and throughput with low complexity, dielectric metasurfaces will here enable a nanophotonic equivalent of numerical aperture filtering while also providing homogeneous signal enhancement for each particle. The extensive expertise of my host, NanoLab at the University of Trento (UNITN), in the integration of silicon photonic platforms and computation, will be critical for this project. In collaboration with the clinical environment I currently work in, MetaScat is designed to meet the need for scaling and implementing easy-to-use, low-cost technology for single extracellular vesicle analysis in clinical laboratories and enable a wider use for early disease detection.

Mots clés : silicon photonics, nanophotonic devices, label free imaging, liquid biopsy, extracellular vesicles, guided mode resonances

Participants :
- Université de Trente (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet AFM (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This research project on Affect, Form and Matter in 17th-Century Lyric Poetry (AFM) aims to trace the formal, material and textu(r)al entanglements of affect in English metaphysical poetry and to find a new methodology of reading (for) affect in literary texts. The project’s fundamental claims are that (1) affect is entangled in a text’s form, materiality and cultural-historical contexts and that (2) it is a constitutive element of metaphysical poetry and accounts for the particularities of this style of early modern writing. To come to terms with affect’s complex textual entanglements, a new methodology, tentatively called “differential reading,” will be developed. Differential reading is an integrative method that combines approaches from affect studies, new formalism, new materialism and cognitive studies but also pays heed to the cultural-historical contexts of production and reception that impact on a text’s affectivity. Differential reading will serve as the central approach to metaphysical poetry as well as to poetry by 17th-century women writers who are not typically classified as ‘metaphysical,’ but whose poems show similar affective-stylistic entanglements. The project will result in differential readings of a range of 17th-century poems that will show the centrality of affects to the metaphysical style. Poetic affect will be traced across different modes and motifs that are both key to metaphysical poetry and to the experience of affect, namely seeing and hearing as sensory modes of affective encounter; time and space as affectively inflected modes of perception and orientation; and material objects as cultural-historical sites of affective encounters. Finally, the project will also consider how these poems metapoetically reflect their own engagement with affect. The project’s results will be of use not only for the field of early modern literature, but for researchers in literature and affect and in the wider field of affect studies alike.

Mots clés : affect studies, metaphysical poetry, early modern literature, new formalism, new materialism, textual performativity, lyric poetry

Participants :
- Université de Newcastle upon Tyne (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet PTSTORM (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Extreme precipitation-related disasters are causing serious concern to our society. Especially over the last few years, their intensity and frequency have become substantial throughout the globe, a trend that is projected to continue in the coming decades. While existing studies indicate that extreme precipitation increases with temperature—a phenomenon known as scaling—the exact rates of this increase are not spatially homogeneous, and global distribution remains highly debated. Furthermore, current literature has only considered temperature, with no studies examining how different storm types and global circulation patterns could affect this scaling rate, especially at the global level. Since extreme precipitation results from complex phenomena and depends on multiple factors, accurately forecasting and predicting these events is extremely challenging. This, in turn, hampers early warming, efficient mitigation, and strategic planning for such future events. Addressing these research gaps, the PTSTORM project introduces a novel approach to estimating how storm types and global circulation patterns can modulate the scaling of extremes. The project is interdisciplinary in nature and incorporates a range of datasets from satellites, reanalysis, and observations. The project will have significant societal impacts as it will play a pivotal role in providing a broader understanding of the physical mechanism behind the extremes and, consequently, preparing mitigation plans accordingly. Furthermore, it is in line with the EU strategy for the sustainable development goal 13 'Climate action' and thus contributes to the enhancement of EU scientific excellence. Moreover, the project will enhance the researcher's career growth, expand his knowledge and expertise in the field of atmospheric science, and enhance his collaboration.

Mots clés : extreme, scaling, precipitation, temperature, satellite precipitation, gpm imerg, era5

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
- Université de Newcastle upon Tyne (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SOLAR-CAT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Fossil fuels are our primary energy sources; however, their combustion causes climate change due to the production of greenhouse gases such as carbon dioxide (CO2). A key solution to climate change is the direct solar-powered production of fuels from CO2. SOLAR-CAT links the conversion of CO2 into high value chemicals with the oxidation of biomass derivatives. This project aims to develop photocatalytic systems that will operate in aqueous media without any sacrificial reagent utilizing only earth abundant chemicals. The developed dye-sensitized photocatalytic systems (DSPs) will contain cobalt complexes of quaterpyridine and 2,2,6,6-tetramethyl-1-piperidine N-oxyl (TEMPO) derivatives as catalysts for CO2 reduction and biomass oxidation, respectively. During the first part of the fellowship, under the supervision of Dr. Fabrice Odobel (Centre National de Recherche Scientifique, CNRS), the fellow will be trained in alcohol oxidation, photo-induced electron transfer, and the development of dye-sensitized systems. During his secondment at University of Paris (UP), he will be trained by Prof. Marc Robert’s research group in electrochemistry, CO2 catalysis and surface chemistry. The fellow’s experience in photocatalysis, molecular synthesis, and DSP development will provide a unique opportunity for the host group to apply their knowledge in DSPs to simultaneous photo-induced CO2 reduction and alcohol oxidation. SOLAR-CAT is a highly inter- and multi-disciplinary project as it brings together the fields of molecular synthesis, catalysis, material sciences, electro- and photo-chemistry, and analytical chemistry. This project will enable the transition of the fellow from recognized researcher (R2) to an established researcher (R3) reaching his career goal (tenure track position in academia), throughout the scientific and personal training actions, the development of his transferable skills, the coordination and the management of the project.

Mots clés : artificial photosynthesis, photocatalysis, co2 reduction, alcohol oxidation, biomass, electrocatalysis, photosensitizer, catalyst, semiconductor

Participants :
- Nantes Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Paris Cité (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet EPIMECH (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Intestine epithelium (IE) compartmentalization and morphogenesis are profoundly influenced by intrinsic biochemical signals and microenvironmental cues in the extracellular matrix (ECM), especially viscoelasticity. Recent studies have revealed substrate mechanical properties have clear influences on intestine stem cell (ISC) fate, IE polarity, self-organization and morphogenesis. However, most of these investigations were performed in constant and static conditions, neglecting the active and dynamic nature of in vivo ECM. Furthermore, whether and how dynamic matrix viscoelasticity contributes to the emergence of symmetry breaking and tissue regionalization in early intestinal morphogenesis remains elusive so far. In this project, we propose to use dynamic hydrogel-based matrices with light-triggerable changes in viscoelasticity to study the transduction of molecular mechanosensing into collective cell dynamics during symmetry breaking and tissue patterning in IE development. We hypothesize that anisotropic substrate viscoelasticity could heterogeneously activate mechanosensing pathways in ISCs and affect ISC proliferation and differentiation, leading to changes in cell activities, sorting and tissue segregation. In brief, with dynamic substrates, we will create viscoelastic patterns/gradients by in situ light patterning and elucidate IE dynamics related to the emergence of cell shape, migration, ISC fate and tissue compartmentalization as functions of the mechanical stimuli. We also aim to identify the molecular principles of IE mechanotransduction, which will improve our understanding of IE development, morphogenesis and homeostasis. The know-how from this project will also enable the fabrication of artificial intestine-on-a-chip devices for further developmental studies. Relying on the multidiscipline approaches, this action will greatly enhance the competence of the researcher as well as bring added value in scientific and societal aspects for the EU.

Mots clés : mechanotransduction active mechancial cues dynamic hydrogel tissue mechanics intestinal morphogensis

Participants :
- Université Paris Cité (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €