Projet INSPIRED (Horizon 2020, appel à projets 2016)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : CLOSED

The overarching objective of this Interfere to Suppress or Promote IRE1 (INSPIRED) RISE programme is to drive research and innovation in cell stress and drug development for cancer and neurodegenerative diseases by forming an interdisciplinary and intersectoral network of experts with strong, dynamic and productive interactions. The partners will work together, each bringing their unique expertise, to develop new classes of therapeutics for these common diseases. By fostering a shared culture of research, innovation and collaboration, the participants will accelerate advances in the field of cell stress responses. The staff members who participate in the programme will develop new skills, learn new technologies and be exposed to new environments which will considerably enhance their career opportunities. Advancing drug development in the stress response field has potential translational and commercial opportunities for the participants and will benefit European society as a whole from economic and health perspectives. IRE1 is a stress sensor and signal transducer, activated in response to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). Its activation is part of a process termed the unfolded protein response (UPR) that determines the fate of cells in response to ER stress. The INSPIRED consortium will focus on understanding IRE1 signalling and its role in the stress response in order to target it in specific diseases such as cancers and neurodegenerative disorders where aberrant IRE1 signalling occurs. Research carried out by INSPIRED partners will develop new IRE1 modulators and generate preclinical data to support targeting IRE1 in cancers and neurodegenerative disease.

Mots clés : endoplasmic reticulum  er, er stress response, ire1, autophagy, cancer, neurodegeneration, therapy, drug design, unfolded protein response  upr, regulated ire1, dependent mrna decay  ridd

Participants :
- Cell Stress Discoveries (Irlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 157500.0 €
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 342000.0 €
- Enios applications idiotiki kefalaiouchiki etaireia (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 162000.0 €
- University of Gothenburg (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 27000.0 €
- University of Chile (Chili) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Metasysx gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 9000.0 €
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 135000.0 €
- MannKind Corporation (United States) (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Orinove inc (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €