Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HSAFE (Horizon Europe, appel à projets 2024)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : SIGNED

The focus of the HSAFE project, which aligns with the specific objectives of the Marie Curie SE-2024 call, is to develop an ultrasensitive diagnostic tool necessary for the identification and detection of lung and lymphoma cancer cells at an earlier stage of development. Early detection significantly increases the chances of a complete cure for the patient. The project proposes to produce a new biosensor based on an avalanche FET array and innovative 2D materials to overcome some disadvantages of traditional cancer detection methods, such as being time-consuming, expensive, and lacking in sensitivity and specificity. The successful implementation of the project will be ensured by sharing the experience and knowledge gained in the fields of physics, technology, and engineering in a coordinated manner. Strengthening modern knowledge in the field of sensors and applying modern technological approaches and methods will be achieved through the international cooperation of highly qualified scientists and engineers from Azerbaijan, the Czech Republic, Hungary, Portugal, Poland, Turkey, and Ukraine. This consortium will address both technological (e.g., micro-sized sensor design, biosensor reader production) and fundamental (e.g., innovative material synthesis, internal avalanche amplification mechanisms of ultra-weak signals, biomarker immobilization process) issues.

Mots clés : field effect transistor based biosensors, cancer diagnostic, diagnostic tools, and public health

Participants :
- Ist micro sensor technolojileri anonim sirketi (Turquie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 255510.0 €
- Université de Bohême de l'Ouest (Rép. Tchèque) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 215430.0 €
- Elmek mozgasban alapitvany (Hongrie) — Partner, beneficiary, Recherche, subvention : 245490.0 €
- Setm limited liability company (Azerbaïdjan) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Uludağ (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 240480.0 €
- Nanomaterials research & development sp. z.o.o (Pologne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 185370.0 €
- V.E. Lashkaryov Institute of Semiconductor Physics (Ukraine) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 120240.0 €
- Radiasiya prolemleri institutu azerbaycan millielmler akademiyasi (Azerbaïdjan) — Partner, associated partner, Recherche, subvention : 0.0 €
- Associacao deeptechlab (Portugal) — Partner, beneficiary, Recherche, subvention : 355710.0 €
Projet ROBUST (Horizon Europe, appel à projets 2021)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : SIGNED

The population in Europe is living longer and healthier, and that is a great achievement. On the other hand, an ageing population raises major financial and social challenges. One in four (25%) persons living in Europe could be aged 65+ by 2050. The greater expectancy of life in Europe is posing serious challenges to healthcare, namely through the associated increasing incidence of various diseases, as well as health conditions, which the elderly are mostly prone. One of the latter conditions is bone fractures, which can typically occur as a consequence of osteoporosis. Furthermore, the consequences of associated complications in fracture recovering include further costs, not only for the patient but also for the European society in general. To address such growing issue, the multidisciplinary consortium of ROBUST takes this as a challenging use case for demonstrating the relevance and proficiency of smart mobile eHealth systems as innovative solutions to address surging issues in our ageing society. ROBUST targets developing a new concept and platform for remote monitoring of patients’ healing process, in the eHealth domain. An integrated mobile eHealth system will be devised exploiting recent advances in RF-based sensing technologies, which are being investigated in this consortium. The system will be able to respond promptly to dynamic and complex situations, while preserving control, safety and privacy, in a reliable and energy efficiency manner. The ROBUST system will include a fast feedback loop that dynamically processes sensing information to generate, accordingly, instructions to the patient, encompassing cognitive and learning capabilities as well. ROBUST is committed to create an exceptional network, which is multidisciplinary and intersectoral in nature, for staff exchange in the mobile eHealth field, namely targeting structure training and knowledge sharing towards enhancing the European innovation capacity in relevant eHealth systems and applications.

Mots clés : healthcare, rf based sensing technologies, control, safety, privacy, energy efficiency

Participants :
- Evotel informatica sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 220800.0 €
- Université de Patras (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 220800.0 €
- Projecto Desenvolvimento Manutenção Formação e Consultadoria (Portugal) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 220800.0 €
- Université de Bradford (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Instituto de Telecomunicações (Portugal) — Coordinator, beneficiary, Recherche, subvention : 220800.0 €
Projet METNEDIA (Horizon Europe, appel à projets 2024)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : SIGNED

The prevalence of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Amyotrophic lateral sclerosis and frontotemporal dementia, continues to rise, partly due to increasing life expectancy. The diagnosis of these disorders remains a significant challenge due to overlapping symptoms, delayed recognition of early symptoms often mistaken for normal aging, and variability in symptom presentation across patients. METNEDIA will tackle these challenges by proposing a new framework for the development of a diagnostic tool. METNEDIA will utilize metabolomic analysis and artificial intelligence to develop a diagnostic tool for the diagnosis of neurodegenerative diseases. A discovery phase will be initially performed using untargeted metabolomic approaches to identify most relevant biomarkers. The project will then develop of a diagnostic kit based on mass spectrometry and artificial intelligence for the diagnosis of widely diffuse neurodegenerative diseases. A multicenter validation of the kit will be also performed. Neurotoxic evaluation of molecules identified as relevant for each disease will be evaluated in vitro. Finally, bioinformatic and machine learning will be used to gaining insight on the biology of neurodegenerative disorders using in vitro and in vivo data.

Mots clés : diagnostic

Participants :
- NovaMechanics (Cyprus) (Chypre) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 165330.0 €
- S e & c idiotiki kefalaiouchiki etaireia (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 135270.0 €
- Institut chypriote de neurologie et de génétique (Chypre) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 120240.0 €
- Capital Region of Denmark (Danemark) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 180360.0 €
- University of Piemonte Orientale Amedeo Avogadro (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 205410.0 €
- Université de Londres (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 180360.0 €
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 120240.0 €
Projet NanoCosmos (Horizon Europe, appel à projets 2021)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : SIGNED

The main aim of the NanoCosmos project is to create a European multidisciplinary and intersectorial network to harness the recovery of valuable bioactive compounds from plant by-product matrices for nano-applications in the cosmetics industry. The project will ensure (i) exchange of knowledge on bioactive compound properties, (ii) optimization of green extraction processes of such compounds from plant by-product materials, (iii) creation of innovative nanoencapsulated biocomponents for cosmetics formulations, mainly targeted on human sensitive skins. NanoCosmos project will aim at enhancing cross fertilization in the area of bioactive compounds from different plant by-product materials which will result in a more cost-effective use of skills and resources in circular bioeconomy. It will also involve hands-on practice in different analytical methods in connection with industrial scale-up, performed by both young researchers/PhD students (ESR), experienced researchers (ER) and experienced academics. Science and business cooperation will allow the development of a joint research network to address current needs in the area of the cosmetic industry. The project will promote university business dialogue and partnership especially in the context of greater involvement of practitioners in the preparation of ESR career development.

Mots clés : plant by products nanoencapsulation green extraction techniques bioactive compounds sensitive skin cosmetics

Participants :
- Stergios tzimikas i.k.e. (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 119600.0 €
- Université nationale et capodistrienne d'Athènes (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230000.0 €
- Dermopartners s.l. (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 156400.0 €
- University College Dublin (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 156400.0 €
- Bionos biotech sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 119600.0 €
- Edmund Mach Foundation (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 92000.0 €
- Dimitra (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 119600.0 €
Projet CLUSTER-INN (Horizon Europe, appel à projets 2022)
Action : Staff Exchanges
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Energy generation and use obtained new urgency the last year when Russia invaded Ukraine. European and other countries encountered harsh realities when problems related to energy availability and affordability had to be tackled. An urgent need for faster and more efficient transitioning towards renewable sources is evident. The project proposal lies within priority research and innovation. It intends to bring together the scientists and practitioners and involve experienced researchers and early-stage researchers in social sciences, electrical engineering, physics and environmental sciences. Scientists will interact with managers of large-scale solar park clusters in Egypt and Morocco, which would allow understanding specifics and scale of problems related to renewable energy production, use and trade. An interdisciplinary/multidisciplinary approach here may lead to novel solutions, which may have important policy implications. We intend to build a cluster for innovative energy, which will involve other clusters already created in the former Horizon 2020 and other projects. The cluster for innovative energy would be a cluster of clusters allowing broad engagement of scientists, practitioners, policymakers, NGOs and other stakeholders. In the context of the war, innovative solutions stemming from the inter-sectoral cooperation of geographically remoted partners can become resilience drivers. The project is based on previous work but goes beyond since it generates and strengthens long-term collaborations via training researchers, encouraging geographical mobility, and fostering exchange between sectors and disciplines.

Mots clés : energy security, solar energy parks, behavioral change, values, renewables

Participants :
- Université de Rome III (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 193200.0 €
- Fundacja centrum badan socjologicznych (Pologne) — Partner, beneficiary, Autres, subvention : 239200.0 €
- Université Sidi Mohamed Ben Abdellah (Maroc) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Vilnius Tech (Lituanie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 404800.0 €
- École polytechnique de Rzeszów (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 101200.0 €
Projet Regeneration (Horizon Europe, appel à projets 2022)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : SIGNED

REGENERATION aims to (i) build a multidisciplinary research network involving experts of technical and medical disciplines to merge their expertise and exploit possible synergies for the development of reliable and sustainable in vitro cell models of healthy and aged bone tissue treated with or without QMR (Quantum Molecular Resonance) and (ii) train a cohort of scientists and technologists in exploiting the model features to increase knowledge on the effects of aging on bone biology and mechanobiology, and on bone response to QMR, to leverage the use of cell models in clinics and basic/industrial research labs. Bone aging reduces the quality of life of the elderly and puts social and economic burden on society. Aging bones fail more easily when challenged mechanically or with toxicants or pollutants, and respond differently to drugs than healthy bone. To personalize therapies and enable better preventive care for the elderly it is essential to develop reliable and sustainable in vitro models of aged bone tissue alternative to animal tests which often fail to capture human-specific features. REGENERATION will involve 7 participants from 4 countries (Italy, France, Greece and Switzerland) and with 3 academic partners and 4 SMEs. The networking activities planned in REGENERATION will generate new knowledge about the mechanisms of bone growth, regeneration and aging, about drug and technologies development for bone pathologies and will study the effect of QMR stimuli in cell proliferation, differentiation and trasfection by in vitro and computational models.

Mots clés : quantum molecular resonance, bioreactors, cell culture, modelling, bone tissue

Participants :
- Conseil national de la recherche (Italie) — Partner, beneficiary, Recherche, subvention : 165600.0 €
- Telea biotech srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 46000.0 €
- Cellex srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 184000.0 €
- Eden tech (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 46000.0 €
- Efiis sistemiki viologia monoprosopi ike (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 138000.0 €
- Haute école spécialisée de la Suisse italienne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Athena Research and Innovation Center In Information Communication & Knowledge Technologies (Grèce) — Coordinator, beneficiary, Recherche, subvention : 165600.0 €
Projet SMARTWASTE (Horizon Europe, appel à projets 2021)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : SIGNED

The main objective of the SMARTWASTE MSCA SE project is to form a world class international and inter-sectoral network of organizations, working on a joint research programme in the field of novel Sustainable Smart Textile Materials, by replacing conventional and high costs textile materials with sustainable, environmentally friendly, cheaper and novel materials such as cellulose fibres from tomato stems waste and creating nonwovens from unconventional poplar seed fibers. This can only be achieved by bringing together world-class experts in materials, polymers, environmentalists, chemists, software engineers, and designers with state-of-the-art innovations and processes in their respective fields of expertise. The participants will exchange skills and knowledge to create sustainable textile materials, strengthening collaborative research between different countries and sectors. SMARTWASTE will also refine and produce potential commercial market opportunities for non-academic participants in the project (WP7). Our goal is to train next generation of researchers and innovators in sustainable textiles through cross-sectoral and training modules. The staff members will develop new skills, be exposed to new research and innovation environments, international networks, new industrial processes and techniques whilst widening and enriching career development through cross-sectoral knowledge transfer and international mobility.

Mots clés : tomato fibre, sustainability, metal coating, conductive textiles, 

Participants :
- Tech2market spolka z ograniczona odpowiedzialnoscia (Pologne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 55200.0 €
- Toeters mientje jennigje (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 9200.0 €
- Université de Manchester (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Technologie de Kaiserslautern (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110400.0 €
- Itunova teknoloji anonim sirketi (Turquie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 41400.0 €
- Université technique d'Istanbul (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 322000.0 €
- Grado zero lab srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 96600.0 €
- Université technologique de Dresde (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 9200.0 €
- Université de Marmara (Turquie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 92000.0 €
- Akilli tekstil ve sanayi limited sirketi (Turquie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 133400.0 €
Projet MAPoPHAGY (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Autophagy (from the Greek for “self eating”) is a catabolic process, by which eukaryotic cells degrade and recycle their content. This mechanism removes superfluous, damaged or harmful molecules or organelles and thus greatly impacts fitness of the organism. Autophagic cargo destined for degradation is delivered to the lytic compartment by specialized vesicles, autophagosomes. As of yet, the path from the plant autophagosomes assembly site to the lytic vacuole is uncharted territory. The first objective of this project is to perform a systematic study investigating the dynamic changes in morphology and biochemistry of the plant maturing autophagosomes and creating a molecular map of their route towards the lytic vacuole. This knowledge will be a fundamental contribution to the plant autophagy and plant membrane trafficking research fields. Autophagy is involved in regulating plant longevity, fecundity, stress tolerance and pathogen resistance. Unfortunately, our understanding of its role in establishing these traits is limited by the autophagy detection tools currently available. In this project I will establish the first high sensitivity luminescence-based non-invasive system for in planta detection of autophagic activity. This approach will be a break-through, as it will finally allow real-time in planta tracking of previously undetectable oscillations of autophagic activity throughout plant development under variable conditions. During the past ten years I became an expert in plant autophagy research. My host, Prof. Schumacher, is a world renowned scholar in plant membrane trafficking and lytic vacuole biogenesis. Mutual exchange of our expertise will greatly benefit the project, expand our skills and broaden our scientific networks. Furthermore, this project is a very important step in my career development, as I will join a new field of studies, work in a new scientific environment with an outstanding reputation and markedly strengthen my line of research.

Mots clés : plant autophagosome maturation, acidification of endomembrane compartments, vesicle trafficking, autophagosomal membrane proteins, tethering complexes

Participants :
- Heidelberg University (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171460.8 €
Projet INCAGE (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Autophagy, an intracellular degradation process, is an important defence mechanism against pathogenic bacteria, including the Gram-negative enteroinvasive human pathogen Shigella flexneri. Work has shown that septins, a component of the cytoskeleton that interacts with membranes, entrap cytosolic Shigella in cage-like structures for targeting to autophagy. However, the factors mediating septin cage formation are mostly unknown. The Mostowy lab has recently discovered that mitochondria are required for efficient septin cage assembly and that ~50% of entrapped Shigella are metabolically inactive. The precise fate of septin cage-entrapped bacterium (replication, persistence, death) remains to be defined. For my project, called INCAGE, I will reconstitute the septin cage in vitro and study host and bacterial factors that modulate septin assembly. I will purify septin complexes and reconstitute septin assemblies (filaments, rings, cages) in vitro, and investigate how auxiliary components (actin, mitochondria, endoplasmic reticulum) influence septin cage assembly. This will reveal how septins recognize bacteria and how they assemble into cage-like structures. In parallel, I will follow septin cage-entrapped Shigella at the level of the single cell to study the lethal action of septin caging and uncover mechanisms that enable bacterial survival. I will test if the subpopulation of septin cage entrapped bacteria that stay alive, can replicate or led to the formation of persister cells (transiently refractory to stress) able to cope with host imposed stress (antibiotics, autophagy). Completion of these objectives will identify factors that promote septin cage assembly and its lethal action against entrapped bacteria. In depth understanding of septin cage assembly and its antibacterial activity can reveal important information about septin biology and cell-autonomous immunity, and help to design novel approaches to counteract bacterial infections.

Mots clés : autophagy, cytoskeleton, septin, shigella, single cell

Participants :
- Imperial College London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 129947.15 €
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 53507.65 €