Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet M3DEA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

We are aware that global climate change and its consequences are a pressing concern, and that heritage monuments are particularly sensitive and increasingly vulnerable. The comparison between photographic reports on monuments and historical copies reveals at a glance the surface transformations over short periods, with severe impact on details readability. M3DEA offers an overarching strategy for the development of a new Diagnostic Imaging Model (DIM) which aims to quantify the stone recession rate in carbonate rocks by comparing high-resolution 3D reconstructions obtained from the Trajan’s Column in Rome (113 A.D., Italy) and those obtained from its historical replicas (1667-1670, 1861-1862, 1939-1943) and photographic reports realized during a major last century restauration work (1980-1990). M3DEA proposes a risk assessment approach that i) combines laboratory tests, on-site surveys, and 3D modelling to provide quantitative indicators highly representative of potential climate change effects on long-time scale, based on multi-scale phenomena from the current state of decay and historical climate data; ii) identifies the main environmental stressors and refine the dose-response functions (DRFs) in order to foresee future deterioration patterns with reliable simulations according to the Intergovernmental Panel on Climate Change (IPCC) scenarios (e.g., to years 2050, 2100); iii) considers the loss of surface material in relation to a hierarchical classification of geometrical features and converts stone recession in terms of Loss of Details (LoD), which will be further elaborated as to decline of Future Cultural Value (FCV) with 3D visual projections; iv) develops a DIM suitable to be implemented on a larger scale. M3DEA aims to raise awareness on cultural heritage vulnerability and to support custom remediation strategies for specific stone surface features and climate conditions providing a useful tool to be used in preservation plans of historical areas.

Mots clés : climate change cultural heritage 3d modelling aging tests surface recession dose response functions rain water ipcc future scenarios

Participants :
- Université de Grenade (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 256442.88 €
- Université de Calgary (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ezEmbedMagnet (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

A reliable ab initio description of molecular magnets is key to developing a new era of quantum devices that will be more efficient and easier to tune by structural modification of their building units. However, quantum mechanical treatment of such systems is challenging due to their multi-configurational wavefunctions, requiring a well balanced description of their constituent electronic configurations. Furthermore, these systems are often large magnetic molecules or atoms deposited on supports whose models include hundreds of atoms, hampering the application of accurate ab initio methods; yet small energy gaps (from tens to hundreds of wavenumbers) call for quantitative accuracy. The aim of this project is to design new molecular magnets, practical for real-world applications. To this end, I will employ a new and affordable computational strategy that combines accurate equation-of-motion coupled-cluster (EOM-CC) theory on the magnetic center with more approximate density functional theory (DFT) on the remainder, avoiding costly EOM-CC calculations on the full system. I will combine interdisciplinary approaches, EOM-CC-in-DFT for open-shell species and tools computing magnetic properties from ab initio calculations, to determine how microscopic interactions (spin-orbit and Zeeman) contribute to macroscopic magnetic properties and how these are optimized in two model systems: (i) a cobalt(II) single-molecule magnet and (ii) single cobalt atoms on the MgO(001) and Cu(111) surfaces. This project will enable, through collaboration between researchers with complementary expertise, a transfer of knowledge across multiple fields, such as solid-state physics, quantum chemistry, and molecular magnetism. Via research training including a secondment, I will explore new approaches; e.g. modelling metal surfaces, periodic wavefunction theories, and periodic embedding theories, which will be crucial to cultivating my place as an expert in this field.

Mots clés : electronic structure, open shell species, magnetic properties, quantum technologies, quantum embedding theories, equation of motion coupled cluster theory

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
- Université technique de Vienne (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet HYHP (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Heat pipes (HPs) are one of the highly efficient passive devices used for heat transfer from one place to another. Recent HP technologies have shown auspicious results in several applications, especially where there is limited space and the necessity of high heat flux, such as in aerospace and automotive industries, cooling of computers, cell phones, fuel production, HVAC systems, and renewable energy systems. Although HPs offer acceptable ranges of thermal efficiencies today, achieving higher efficiencies could make a revolution in their applicability, making them a dramatically more effective tool for the mentioned applications and even many others. Hence, this project proposes a first-of-its-kind and revolutionary approach for the performance enhancement of heat transfer tools, especially in HPs. The method centers around the use of salt hydrate (SH) materials with positive enthalpy of dissolution as the working fluid. The project pursues several specific research objectives, including 1) developing the first SH-HP using the primary choice material of NH4NO3, 2) finding and testing potential alternatives for the benchmark material, 3) thermal and flow simulation (CFD) of HPs (in various designs) with the selected materials as working fluid, 4) thermal behavior optimization of the SH-HPs, 5) experimental verification of the modeling results on the SH-HPs in the lab, and 6) carrying out a risk analysis, life cycle cost, and life cycle assessment of the developed HPs. It is expected that the enhancement to be made in HPs’ design and performance could be advantageous for a wide range of thermal energy systems, especially those for the exploitation of renewable energy e.g., geothermal systems, solar evacuated collectors, etc.

Mots clés : heat pipe thermochemical material endothermic materials heat transfer system level optimization life cycle assessment computational fluid dynamics

Participants :
- Université technique du Danemark (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
- Université technique de Vienne (Autriche) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet COLORnamental (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The COLORnamental team comprises a promising Experienced Researcher (ER) in the field of horticulture and molecular breeding and her future supervising team, i.e. an academic beneficiary in Austria, an associated partner from the commercial horticultural industry in Germany and an academic associated partner in Germany hosting a 6 month secondment. Together they have defined an innovative and challenging research project that offers a well-balanced mixture of research at the interface of fundamental and applied research addressing promising opportunities in the non-academic sector and scientific hot-spots in plant research simultaneously. An innovative breeding approach will exploit flower colour as an established model to implement for the first time the use of MAD7 nucleases in ornamental breeding, and protoplast transformation to modify the bract colour of poinsettia. The genome editing approach addresses the substrate specificity of dihydrolflavonol 4-reductase (DFR) and will promote the accumulation of orange pelargonidin based pigments. Flavonoids, including the colourful anthocyanins, are the most important secondary metabolites, contributing a broad range of physiological functions in plants and humans, the latter when consumed as plant derived food. This makes them an attractive topic for industry and academia across many research fields. The pathway has always served as an important model to establish fundamental scientific knowledge of enzymes, gene regulation in plants and a variety of evolutionary processes. This will allow the ER to augment her expertise with knowledge that is seen as the future of food security, while herself imparting a new perspective to her hosts. A tailor-made training plan, composed of scientific key transferable skills elements for public and private sector employment (research management, presentation and language skills) was designed to empower the ER to move up the career ladder.

Mots clés : ornamental plants, flower colour, breeding genome editing, protoplasts, anthocyanin, poinsettia, bracts, crispr, endonuclease, dihydroflavonol 4 reductase, flavonoid 3 hydroxylase, pelargonidin

Participants :
- Federal Research Centre for Cultivated Plants (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Klemm and sohn gmbh and co kg (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université technique de Vienne (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 249301.2 €
Projet GYNODICY (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This project aims at producing the first comprehensive study of the philosophical problem of “gynodicy”, i.e., the incompatibility of, on one hand, a rational defence of women as naturally equal in capacities and in rights to men and, on the other, their factual subjection to men. GYNODICY concentrates on gender-egalitarian texts from the early modern period that circulated within European philosophical culture and specifically on the gender-egalitarian fictions of origin these texts put forth with the objective of arguing against the naturalisation of women’s submission to men. This study is important because the authors of said sources developed the intellectual foundations of the defence of the “equality of the sexes”, which lead to women’s civic and political enfranchisement. These writings on gynodicy have been generally overlooked in academic research, thus contributing to consolidate an incomplete panorama of early modern political thought. GYNODICY seeks to counter this by proposing a new narrative that recovers a body of literature comprised of both printed works and unedited manuscripts, which has hitherto received scanty attention. The project promotes a transnational approach to the circulation of gender-egalitarian ideas and an interdisciplinary perspective. Natalia Zorrilla’s experience studying fictions of origin in clandestine philosophical literature and early modern women philosophers make her the ideal researcher for this project. She will benefit from the expertise of her supervisors: Marguerite Deslauriers (McGill University, outgoing phase) and Marco Sgarbi (Ca’ Foscari University of Venice, return phase). Thanks to the training planned during this GF, Zorrilla will acquire new skills and establish an international scientific network connecting Europe and the Americas, thus becoming a leading scholar in early modern philosophy.

Mots clés : gender egalitarianism early modern political philosophy querelle des femmes

Participants :
- Université Ca' Foscari de Venise (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187248.96 €
- Université McGill (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet BCLC-TANGO (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Europe faces the imperatives of green and digital transition, continually seeking novel nanoscale materials. Smart soft nanomaterials, with their responsiveness to stimuli open a wide range of application to meet industrial and societal challenges, while supramolecular chemistry enables tailoring captivating architectures and functionalities. For the goal of closing research-technology loop, BCLC-TANGO’s objective is to develop innovative functional soft materials through leveraging the orthogonal “self-assembly dancing” of bent-core molecules, with focus on BC liquid crystals and tailored aggregates and nanostructures, as well as on the exploration of suitable processing options.  In this Marie Skłodowska-Curie Action, Dr. Mašulović will receive crucial training at the Instituto de Nanociencia y Materiales de Aragón (INMA)-University of Zaragoza, under the supervision of Prof. Maria Blanca Ros. Fundamental approach of organic synthesis and supramolecular chemistry will be used, along with modern techniques of material and nanoscience to design and synthesize novel bent-core molecules (1), to broadly characterize them exploring functional properties suitable for application (2) and increase their real applied potential through processing (3). During 6 months of secondment at the Institute for Molecular Systems Engineering and Advanced Materials, University of Heidelberg, under supervision of Prof. Eva Blasco, she will explore a novel approach of 3D/4D printing for some of these supramolecular materials as one of the processing methods. This project will pave the way for the development of easily manipulable smart soft nanomaterials, with tunable properties, having a far-reaching implication for industries. In addition to promoting women education in STEM, the fellowship will have a formative and highly beneficial effect for Dr. Mašulović enabling transition from a young researcher to a professional with a valuable set of scientific and transversal skills.

Mots clés : organic chemistry, supramolecular chemistry, soft matter, tailored nanostructures, self assembly, liquid crystals, gels, microfluids, 3d printing, electrospinning, advanced microscopies

Participants :
- Université de Heidelberg (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Saragosse (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet DEXTER (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : TERMINATED

In spite of a growing toolbox of therapies, including classical (radiotherapy, chemotherapy or surgery) and emerging (immunotherapy, precision medicine or hormone therapy) treatments, cancer is a multifaceted global health issue that continues to demand new solutions. The advent of nanotechnology has added nanoparticle (NPs)-based approaches to the available toolbox in cancer therapy. Indeed, we now have NPs with extraordinary properties, including drug loading, antibody functionalization and remote activation capabilities. However, these promising advances have so far failed to materialize in the clinic, largely due to a lack of selective delivery to tumors. DEXTER attempts to change this situation by combining recent multidisciplinary advances in the fields of nanomedicine and extracellular vesicles (EVs). Specifically, DEXTER aims to develop new procedures to create bioartificial EVs that maintain selective targeting properties after loading them with therapeutic NPs. These artificial EVs have the potential to overcome the limitations of using native EVs, whose targeting and immune system-evading properties are compromised after loading with NPs. For this, fundamental problems need to be resolved to realize their potential for application in the clinic. In particular, there is a clear lack of understanding regarding the stability of exosomes during long-term storage as well as their interactions with cells from the immune system in their application in vivo. DEXTER will shed light on the key factors that govern the fate of NPs-loaded exosomes, providing clues to modify them in order to achieve a strong enhancement of their ability for selective delivery of therapeutic loads to tumors. The developing of DEXTER in the host institution will allow me to mature and acquire new research lines, developing new competences in nanotechnology and chemical technology research, and will be crucial to encourage my independency in this stage of my career.

Mots clés : extracellular vesicles, nanoparticles, targeting, cancer, immuno scape

Participants :
- Université de Saragosse (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet SCIseg (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Traumatic spinal cord injury (tSCI) markedly reduces patients’ quality of life and economically burdens health systems. Neurological examinations and clinical magnetic resonance imaging (MRI) scans are currently insufficient for the proper classification of the tSCI baseline level (i.e., severity). Although MRI scans are routinely employed in tSCI patients, the MRI potential is not fully utilised due to the complexity of the analysis and diversity of MRI data across hospitals. The aim of this project is to propose a fully automatic and reproducible analysis tool that could be run by clinicians to improve the clinical management of tSCI patients. First, deep learning models for automatic spinal cord and lesion segmentation from MRI images will be developed to go beyond the currently used error-prone and time-consuming manual segmentations. The models will be trained on a multi institutional MRI dataset to be robust to MRI data heterogeneity across hospitals. Then, quantitative measures of the tSCI severity will be automatically computed from the segmented structures (i.e., spinal cord and lesions) and employed within the statistical model to predict tSCI severity. Finally, the developed methodology will be translated to the real-world healthcare system and tested on a prospectively acquired dataset of tSCI patients. Importantly, deep learning models, analysis pipeline, and statistical model will be seamlessly integrated into the current state-of-the-art ecosystem for spinal cord MRI data analysis and made publicly available to facilitate open science and reproducibility across hospitals. The project will create the first step in the improvement of care and clinical management in millions of patients with tSCI worldwide. In the longer term, after demonstrating the clinical relevance of the proposed tools, we assume that advanced MRI-based methods will be adopted by the larger clinical community for more personalised care.

Mots clés : spinal cord, spinal cord injury, deep learning, magnetic resonance imaging

Participants :
- Université Palacký (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269047.2 €
- Université de Montréal (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SECCAPPEA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

Structuring Effective Climate Change Agreements through Perfect Procedures: an Experimental Approach (SECCAPPEA)   The solution to the climate change problem can be no longer postponed because more and more indicators are showing that we are getting closer to the tipping point of an irreversible process. At the same time, climate change is a global issue that cannot be tackled by means of the commitment of a minority of virtuous agents or communities. Instead, problems of global outreach like the global warming can be solved only through a high degree of international cooperation: this is exactly the main goal of the international agreements on climate actions. However, despite several international agreements signed during the last decades for the global reduction of greenhouse gas emissions, nations have generally failed to comply with the prescriptions of climate change agreements, so that greenhouse gas emissions continue to increase. This lack of commitment produced no relevant changes in terms of reducing the risks related to climate change. The SECCAPPEA project, through methods and tools belonging to behavioural and experimental economics, aims to study and examine perfect procedures as a new way to structure self-enforcing international climate change agreements, so that they can produce tangible results, reducing the likelihood of the world heading into the so-labelled “climate chaos”. The project will last 24 months and will be developed between the School of International and Public Affairs (SIPA) at Columbia University (associate partner for the outgoing phase) under the supervision of Professor Scott Barrett, and the Cognitive and Experimental Economics Laboratory (CEEL) at the University of Trento (beneficiary) under the supervision of Professor Luigi Mittone.

Mots clés : experimental economics game theory

Participants :
- Université Columbia (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Trente (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175737.12 €