Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet TTNPred (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Mutations in the giant muscle protein titin are a major cause of heart disorders in human populations. Routine DNA screening of patient cohorts is now becoming feasible, with a staggering number of titin truncations and missense single nucleotide polymorphisms (mSNPs) rapidly accumulating in genomics databases (>17,000 mSNPs). While the link between titin truncation and disease is now becoming clarified, detecting the pathogenic potential of mSNPs remains a substantial challenge. In mSNPs classification, bioinformatics evaluation is a necessary first filtering step, but existing predictors are poorly reliable. To address this problem, we aim to develop a new titin-centric scoring function that predicts the mechanistic effect of an mSNP exchange in the titin protein by considering the specific characteristics of its poly-domain chain. For this work, we will build a medium-throughput molecular diagnostic pipeline that harvest existent structural models of titin components in estimating mSNPs-induced changes in free energy and conformational dynamics in the protein. Calculations will be benchmarked against experimentally obtained biophysical and biochemical data. To develop this methodology, we will use a clinically pertinent training set of 75 mSNPs. However, in a subsequent step, stable predictions will be extrapolated to the rest of the titin chain by exploiting the repetition of structural and functional loci within the chain. A titin map of vulnerability “hot-spots” so calculated will be distributed to the research community. Ultimately, we aim to produce a tool that can aid clinicians to identify patients at risk of developing a titin-based heart condition at early disease stages, where intervention is still possible.

Mots clés : msnps, protein simulations, protein bioinformatics, protein charcterisation

Participants :
- University of Konstanz (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171460.8 €
Projet WISDOM (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

My Fellowship will explore the interconnection between non-coding RNA and chromatin regulation. Building on a detailed mechanistic base, I will capitalize on the recent proteomic identification of a stable complex FLD/SDG26 by my host lab, which plays a central role in the co-transcriptional silencing of the Arabidopsis floral repressor locus FLC. This protein complex is central to a mechanism determining the quantitative expression level of FLC, and thus the reproductive strategy of the plant. However, these activities also regulate many other targets in the Arabidopsis genome and the conserved nature of the components suggests the deeper understanding gained from this study will be important generally across all eukaryotes. FLD is a histone demethylase with specificity for H3K4; SDG26 is a SET domain protein likely to methylate histones and other proteins, but whose specificity is currently unknown. The splicing and alternative processing of FLC antisense non-coding transcript, COOLAIR, is essential for the repression of FLC transcription. However, how the processing of COOLAIR controls sense transcription remains elusive. My proposal aims to: 1) test the hypothesis that the FLD/SDG26 complex, triggered by FCA/FY-mediated proximal polyadenylation of COOLAIR, delivers a specific chromatin environment, which represses transcriptional output: and 2) explore the missing link between FCA/FY-mediated proximal polyadenylation of COOLAIR and chromatin regulation by FLD/SDG26 complex. My proposal involves interconnections between genetics, biochemistry and molecular biology, enabling me to develop a broader experimental skillset. It directly contributes to the action’s goals to: improve my creative potential and competences through international mobility and advanced training in technical and transferable skills; enhance collaborative and contact networks for both myself and my host lab through academic and public engagement; and drive substantial career development.

Mots clés : arabidopsis, epigenetics, flowering time, antisense non coding rna, histone modification, transcription

Participants :
- UK Research and Innovation (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 195454.8 €
Projet ESSINDEX (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

My aim in the project ESSINDEX is to understand the phenomenon of essential indexicality. Indexicals are linguistic terms such as ‘I’, ‘here’, ‘now’, ‘he’, etc. whose referent varies according to the context of use. For example, an utterance of ‘now’ refers to the time of its utterance. Like other context-dependence phenomena, indexicality had long been regarded as a defect of natural language. But in 1970, it was noticed that some thoughts cannot be expressed or communicated without the help of indexicals. Such thoughts appear to represent the world from a situated perspective in it. This creates a deep problem for traditional doctrines about thought and communication: the “problem of the essential indexical” (PEI). The PEI has generated a vast literature in the last 40 years. It has foundational implications in philosophy of language, philosophy of mind, semantics, and pragmatics. This is the perfect time for a renewed assessment of the PEI: recent sceptics began to complain that the PEI was ill-posed and that essential indexicality was a myth. The novel view I propose to explore in this project integrates insights from both the advocates and the detractors of essential indexicality. It could mark a turning point in debates on the PEI, and thereby have broad implications for the relevant fields. I want to run ESSINDEX under the supervision of François Recanati at the Institut Jean Nicod (IJN), which is partnered with the École Normale Supérieure (ENS) in Paris. Given the unrivalled expertise of F. Recanati on most topics of ESSINDEX, and that of other researchers at IJN on specific issues to be explored in various research fields (philosophy of language/mind/cognitive science, semantics/pragmatics, epistemology), the interdisciplinary team of IJN provides the best possible environment in which to run that project, which directly engages with the current work of several of its researchers.

Mots clés : philosophy of language, philosophy of mind, semantics, pragmatics, theories of, content, direct reference, indexicality, perspectival thought, propositions, centred worlds

Participants :
- École normale supérieure PSL (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173076.0 €
Projet Neuronal Trafficking (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

My long-term goal is to understand the cellular and molecular mechanisms that govern synaptic growth and plasticity, and how dysfunction in these pathways contributes to disease. Neurons are the most morphologically diverse cell type whose morphology determines many functional aspects of a neuronal network. The primary shape of a neuron is established during axon and dendrite outgrowth and synapse formation, but is subject to subsequent modifications by physiological events. In response to changes in synaptic activity, neurons can alter both pre and postsynaptic elements of the synapse. Defects in synaptic morphology and in activity-dependent plasticity are a hallmark of several neurodegenerative and cognitive disorders. It is therefore critical to know the basic mechanisms by which neurons acquire their shape and change it in response to activity, and to dissect the genes that regulate these processes. To address these questions, this proposal is divided in the following aims: 1) To dissect the postsynaptic role of the Ral/exocyst pathway in synaptic growth and activity-dependent plasticity 2) To uncover novel regulators of neuronal membrane trafficking . My strategy is to use the relatively simple nervous system of Drosophila to uncover novel cellular and molecular mechanisms that control synaptic development and plasticity, in order to understand how membrane traffic is regulated to form and modify neuronal structures. Because 75% of all human disease genes have related sequences in Drosophila and nearly a third are predicted to have functionally equivalent counterparts, I expect that these studies in Drosophila will contribute to the dissection of the mechanisms that, when disrupted, may lead to disease. This will help identify points of intervention, therefore directing novel therapies to help curing or ameliorating the symptoms present in many neurological disorders.

Mots clés : synapse, membrane trafficking, exocyst, rab gtpases, synaptic plasticity, synaptic growth, drosophila

Participants :
- Universidade Nova de Lisboa (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160635.6 €
Projet Methodology (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

My post-doctoral project entitled “A New Methodology for Comparative Analysis of the Dead Sea Scrolls and Cognate Literature” will take an integrative approach to the Dead Sea Scrolls (henceforth scrolls), the New Testament and other ancient Jewish literature. It is therewith part of an ongoing and lively debate on how the scrolls can shed new light on and give meaning to texts that have puzzled New Testament scholarship all along. I intend to describe and highlight more prominently the different „evolutionary factors“ like the absence from a sacrificial cult, the focus on a unique canon of formative scriptures, the understanding of the group as a “holy building” and an “eternal planting” (1QS 11:7-9), and the impact of Greco-Roman culture that shaped the language, laws and theology of the communities behind the scrolls. My first challenge when turning to New Testament traditions will be to show how its authors transferred ideas and traditions from a Palestinian Jewish background into a new cultural milieu with an almost entirely different encyclopaedia of knowledge an act that I would call “translation of traditions”. One of the biggest difficulties in tradition-historical comparison between New Testament and Yahadic writings is to determine whether or not the traditions incorporated into New Testament writings are of Palestinian Jewish origin but phrased differently with Greek motives and expressions. Only when we know the “source language” that is the underlying concept behind these expressions we will be able to identify its tradition-historical origin. With the identification of Palestinian Jewish traditions in New Testament writings the last step that is the comparison of concepts that underlie New Testament traditions and the ideas from which Yahadic traditions originated can then be implemented.

Mots clés : new methodology for tradition historical comparison, palestinian jewish traditions in the new testament, translation of traditions, dead sea scrolls, enochic judaism, sectarian writings

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet HighThroughFROGS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

My postdoctoral study is designed to develop protocols and procedures to obtain genomic DNA data from degraded old museum specimens using HTS (e.g., exome-capture and/ or mtDNA genome sequencing) using SE Asian frogs as focal taxa. Specimens housed in natural history museums are essential raw materials for studies of cryptic speciation that is very common in the tropics. These studies require molecular genetic tools that, to date, could only be applied to freshly collected tissue samples. Because HTS is based on short-fragment sequencing technology, it is more effective at obtaining sequence data from historical specimens than Sanger sequencing, particularly for very old samples collected more than 100 years ago. HTS methods will be tested to assess the phylogenetic and taxonomic position of the Asian ranid frogs with gastromyzophorous tadpoles, a group that has defied taxonomic clarification for decades. This proposed study is well aligned to the Work Programme of Horizon 2020 Marie Sklodowska-Curie Actions. The results of this study will be a valuable baseline to assess the feasibility of and to improve exome-capture techniques aimed at retrieving historical DNA from type specimens for future studies. This study will be the first to investigate the evolution of gastromyzophory in Asian ranid frogs. It will also emphasize the need to apply modern techniques in tropical countries with high biodiversity as a critical step in quantifying its diversity and developing conservation actions for cryptic species. Apart from that, this study is an exceptional step towards advancing my career and establish myself as an independent researcher in the field of phylogenetics systematics. Furthermore, I will be able to actively contribute to disseminate my science to broader audience and play an important role as a catalyst for a long term collaborations between the institutions in Germany, USA, and Indonesia in phylogenomic, systematics, and biogeographic studies.

Mots clés : ancient dna, asian ranids, exome capture, gastromyzophorous tadpoles, huia, high throughput sequencing

Participants :
- Universität Hamburg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Leibniz Association (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 246669.12 €
Projet transnat (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

My project discusses trans-territorial aspect of the individual search for retribution for crimes committed during the Second World War in East-Central Europe, focusing specifically on the immediate post-war response of Jewish pre-war Polish citizens to wartime norm-violating behaviour. As Polish Jews left Poland and settled abroad, my research will cross the traditional historiographical post-war divide between “West” and “East”, showing how people moved between those two zones just before the Iron Curtain came down, how they dealt with their memories and how they would go on to build what we refer to, following the conceptual framework developed by Barbara Rosenwein, as emotional communities dened by the social affiliation and shared memories. As such, this project contributes both to writing an integrative, multi-ethnic history of post-war Poland and to the global history of rebuilding of shattered society post-conflict. My work will provide a synthetic interdisciplinary and cross-regional study of the institutions, actors, and larger implications of retribution, while tracing trajectories of individuals and the impact of their journeys on the links between collectives around the world. It will focus on individual agency in seeking retribution, taking into consideration gender, age, social status and geographic location as key aspects in shaping it. The project will be introducing a new methodology, combining research tools of history, history of emotions, legal history and digital humanities. It will be primarily carried out under the supervision of professor Michael Brenner at the Department of Jewish History and Culture at the Ludwig-Maximilians-Universität München (LMU), with a three-month secondment focused on training in the history of Jewish legal representation at the Leibniz-Institut für jüdische Geschichte und Kultur – Simon Dubnow (DI) under the supervision of Dr. Elisabeth Gallas.

Mots clés : jewish history, search for justice, revenge, postwar trials, jewish migration, nation building

Participants :
- Ludwig-Maximilians-Universität München (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 174806.4 €
Projet GISARC (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

My project investigates the impact of Roman domination on Greek in Sicily through the analysis of the written sources that have come down to us and the application of a sociolinguistic perspective. The survival of Greek in Sicily under Roman domination and its interaction with Latin have been long debated, but a comprehensive examination of the epigraphic record, taking into account the full array of historical and archaeological evidence and conducted in the light of modern sociolinguistic theory, remains to be attempted. My research will accomplish this, and in particular it will: assess the use of Greek in different types of text, and its status and function compared to Latin; determine whether differences can be appreciated in the use and survival of Greek in different sites and how these can be put in relation with the socio-historical context; describe the effects of contact between Greek and Latin in the epigraphic sources. Such an investigation is now possible and timely, as an open access digital corpus of all the inscriptions from Sicily is currently under development (I.Sicily) and the next few years will offer opportunities for productive collaborations. My project is innovative in being the first study to consider the whole corpus of inscriptions from Sicily and in its interdisciplinary approach, which combines linguistic analysis with investigation of historical and archaeological data within the theoretical frameworks of sociolinguistics. It will fill a major gap in the scholarship of both Roman Sicily and language contact in antiquity in general, and, through its comprehensive and interdisciplinary perspective, will offer an innovative approach that can be successfully applied to other areas as well. GISARC is what I need at this stage in order to achieve professional maturity as a researcher, and Ca’ Foscari University of Venice is the ideal host institution where to implement it on account of the expertise and training opportunities that it offers.

Mots clés : greek in sicily, roman sicily, ancient greek linguistics, historical sociolinguistics, language contact and bilingualism in antiquity, greek epigraphy

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183473.28 €
Projet Occupational Health (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

My project investigates the relationship between ill-health and working life in early modern Italy (c.1550-1750). The objective is to analyse how workers communicated health problems to employers and, in turn, how employers responded. It provides a ground-breaking perspective on the cultural history of ill-health, taking an occupational health approach to experiences of illness, health in the domestic environment, and public health. Ill-health is broadly conceived, encompassing chronic illness, bouts of ill-health, and injury. Work is defined as ‘the use of time with the goal of making a living.’ Therefore, both paid and unpaid activities are considered, and particular attention is given to women’s work. Italy is a crucial site for analysis as it had a diverse workforce in highly urbanised areas while also being at the forefront of developing public health procedures in Europe, including the regulation of dangerous jobs. Concerns about the health consequences of working practices grew during this period, as demonstrated by a widely circulated treatise on the diseases of workers first published in 1700. I will apply methodological approaches from the history of epistemology to neglected sources including manuscript ‘sick notes’ found in letters, physicians’ notebooks, medical treatises, and regulations created by employers. The project examines how concerns about work activities were integrated into medical discourse and diagnosis, how workers understood and shared health problems, and how occupational health shaped early modern society. Following teaching-focused positions and non-academic employment, I will restart my research career at Ca’ Foscari in Venice where I will have access to archives, work with outstanding researchers and receive career development training. The results will be disseminated through peer-reviewed, open access journals, a project website, a museum exhibition and via academic and public talks.

Mots clés : ill health, work, occupational health, medical epistemology, venice, mantua, early modern europe

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 257209.92 €
Projet RAP (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

My research project will examine and compare the relations of the Papacy with Portugal and Aragon from the pontificate of Alexander II (1061-1073) to that of Innocent III (1198-1216). Portugal and Aragon have been chosen because were the only political realities in the Iberian Peninsula to enjoy the protection of St Peter in these centuries. These relationships have been interpreted as a feudal bond, but recent studies have started to challenge this image. This analysis will fit into and expand recent discussions of the relations between centre (Rome) and periphery, focusing on an ecclesiological perspective. To whom was the Apostolic See writing? And who was writing to Rome? Why? Did the letters concern practical or theoretical matters? What language and images were adopted by Rome to assert its primacy over Portugal and Aragon and what ecclesiological ideas? Was there ever a feudal bond between these political institutions and Rome? Or was the papacy only reacting to events, claiming a role that it could not play? Was there a particular style in use when writing to the pope? Did ecclesiastics and lay powers adopt similar or distinct formulas when writing to the Apostolic See? These are some of the questions the project aims to answer. Letters issued by the papal chancery are the main source for this kind of analysis because they always entailed the official view of the Roman church on a specific matter, showing the communication strategies and the ecclesiological ideas adopted by the Apostolic See to assert Roman primacy. Missives sent to the popes also played a decisive role in the creation of papal images. This project will shed light not only on the papacy and on the strategies adopted to support its claims of primacy, but also on views of the Roman church from a frontier of Christianity, which may (or may not) have been shared by the papacy itself.

Mots clés : church history, medieval papacy

Participants :
- Universidade Católica Portuguesa (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 147815.04 €