Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet HyperDyad (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

With an ever-growing population, reducing our demand for energy is a key challenge in building a sustainable future. As part of tackling this problem, Organic Lighting-emitting Diodes (OLEDs) show great potential for application in low-energy consumption displays, lighting, and lasers. OLEDs are increasingly featured in high end consumer electronics; however, their potential is yet to be realised. Undoubtedly, the largest problem OLEDs face today is the instability of the blue emitter. Commercial OLEDs currently employ either an inefficient but stable blue emitter (resulting in energy wastage) or an efficient but unstable blue emitter (resulting in short-lived devices). By splitting the task of energy conversion and emission between two molecules within a device, stable and efficient blue emission is achievable. However, the current approach is to disperse these two molecules within a host, which leads to unpredictable orientations and distances between molecules. This results in detrimental processes within the device that reduce both efficiency and lifetime. Traditionally thought to be a device engineering problem, I propose a step change in thought. In a new approach to molecule design, I aim to tether the molecules together using a rigid bridging unit, forming a ‘dyad’ which gives precise control over the orientation and distances within a device. I aim to explore the efficiency of energy transfer as a function of the bridging unit to develop a structure-function relationship. The results of this work will establish design criteria for dyads which will facilitate the development of both efficient and stable blue emitters.

Mots clés : organic electronics, organic semiconductors, luminescence, organic light emitting diodes, hyperfluorescence, energy transfer

Participants :
- Helmholtz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188345.36 €
- Université de Göteborg (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet EVOLOCT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Making the most of genomic tools to understand and predict species response to global change is increasingly important, especially in exploited marine species. In EVOLOCT, I aim to determine the genomic basis of local adaptation, while understanding the past, present, and future population dynamics of Octopus vulgaris. This ecologically and economically significant species has recently expanded northwards in the northeast Atlantic, possibly due to climate change or human exploitation, yet the exact causes and the population stability remain unknown. Moreover, while the importance of structural variants (SVs) has been increasingly recognised in underlying ecotypes and cryptic population structures, SVs remain poorly represented in eco-evolutionary studies. To address these gaps, I will integrate modelling, genomics, and environmental data to characterise present population structure and dynamics, reconstruct their demographic history, and predict their future distribution, abundance, and vulnerability. Pushing the boundaries of current genomics studies, I will incorporate SVs beyond the classic SNPs while combining simulated data with empirical data, as a powerful and comprehensive technique in predicting short- and long-term responses to climate change. I will hone my skills at the host lab of Dr Mérot alongside Prof Charrier and Dr Le Luyer, French experts in evolutionary biology and ecology. My secondment with Asst Prof Oomen in Sweden will expand my skills in modelling and SV analyses. Through these collaborations, I will learn new multidisciplinary approaches and techniques in modelling and genomics. EVOLOCT will undoubtedly enable me to gain a competitive advantage in establishing my career in the dynamic and critical field of evolutionary ecology. Finally, EVOLOCT will greatly advance our understanding of the genomic and evolutionary basis underlying local adaptation while allowing scientifically-informed management of exploited marine species like octopuses.

Mots clés : evolution fisheries ecology genomics genomic architecture local adaptation molecular ecology population structure structural variation

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 242260.56 €
- Université de Göteborg (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet GOHE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Since its initial prediction, the spin Hall effect (SHE) has played a major role in spintronics thanks to its intriguing physics and tremendous potential for applications via the spin currents generated from charge currents. In the last few years, another phenomenon, the so-called orbital Hall effect (OHE), has also emerged. The OHE is the generation of pure orbital currents from the charge current, ushering in the era of orbitronics. The magnitude of the OHE is predicted to be 1-2 orders higher than the SHE, and therefore, it is imperative to harness it for the development of spintronic devices, e.g., to use it to excite auto-oscillations at microwave frequencies. Therefore, the Giant Orbital Hall Effect (GOHE) project aims at using the OHE instead of the SHE in spintronic nano-oscillators, to create a paradigm shift in the designing of next-generation orbitronics-based devices. Here, I propose a systematic study of different combinations of non-magnetic (NM)/heavy metal (HM)/ferromagnetic (FM) based heterostructures to harness the OHE and utilize it for the mutual synchronization of the world’s first orbital Hall nano-oscillators (OHNOs), to serve as a bridge to the already known capacity of spin Hall nano-oscillators (SHNOs) by the host group. Moreover, in this project, I aim to reliably elucidate the explicit contribution of bulk and interfacial OHE, in analogy with its counterpart, SHE. I will also study and unravel the fundamental mechanism OHE by disentangling the intrinsic and extrinsic contribution of scattering from impurities in host, and develop its background in line with SHE.

Mots clés : spintronics, spin hall effect, orbital hall effect, spin hall nano oscillators, spin torque ferromagnetic resonance

Participants :
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet IN-FACT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Eukaryotic translation initiation is a process wherein ribosomal subunits are assembled by eukaryotic initiation factor (eIF) proteins. Mammalian eukaryotic translation initiation factor 3 (eIF3), consisting of the 13 subunits eIF3a to eIF3m, is the largest and most complex eIF. Due to the emerging understanding of the role of eIF3 in a wide range of cancers, there is an increasing interest to examine its many subunits as potential therapeutic targets. Furthermore, interactions between subunit eIF3c and tumor suppressor protein schwannomin has been reported to promote development of the tumor neurofibromatosis 2 (NF2). Very few small molecule inhibitors reported targeting eIF3 subunits are reported, and are associated with high degree of uncertainty. There is hence a need to develop new and highly effective small molecules targeting the eIF3 subunits to be used in the treatment of cancer, as well as in the fundamental understanding of the interactions between the various subunits. The aim of this interdisciplinary project is to investigate the structures, dynamics, and interactions of subunits in the eIF3 family, and use this information to design, synthesize and test compounds for targeted cancer therapy. We will employ a range of computational and bioinformatics-based tools (protein-protein docking, molecular dynamics and metadynamics simulations, machine-learning based ligand design and docking techniques) to identify and explore key druggable interactions and regions in the initially targeted subunits eIF3a and c. To verify the inhibitory potential of the designed small molecules, chemical synthesis and in vitro evaluation will be performed. Through the combination of computational modeling, subunit-specific inhibition, and measurements of anticancer activity, we will be able to understand in more detail the mechanisms of action as well as interplay between different subunits, and the interactions between eIF3c and tumor suppressor protein schwannomin.

Mots clés : eif3, cancer, drug design, protein protein interaction

Participants :
- Université polytechnique et économique de Budapest (Hongrie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 222727.68 €
Projet EXTREME (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The exceptionally increasing European heat and cold waves in recent decades have been widely attributed to global warming from a thermodynamic perspective. However, contribution of warming-induced circulation changes to such regional waves (termed the 'human-induced dynamic contribution') remains largely unknown, while midlatitude atmospheric circulations have been altering under global warming. Human fingerprint will not be fully detected if the human-induced dynamic contribution is not included. Dr. Chunlüe Zhou who has an outstanding academic profile in daily data homogenization and regional climate change attribution, will interact with Prof. Deliang Chen (University of Gothenburg, Sweden) to make a robust attribution to quantify human-induced thermodynamic and dynamic contributions in historical changes of regional heat and cold waves over Europe. Human activities include greenhouse gas emissions, aerosol emissions and land use/cover changes. To make robust the attribution, attribution uncertainties arising from observation, model and attribution method uncertainties will be improved through: i) reducing observation errors by removing spurious shifts in the mean and variance of daily series; ii) improving regional details of heat and cold waves and circulation patterns by downscaling large ensembles of global-simulated data using the Weather Research and Forecasting (WRF) model and exploiting feature-based machine learning recognition; and iii) developing a Bayesian statistical approach to separate the human-induced thermodynamic and dynamic contributions. This robust attribution will address these current challenges, but also push event attribution research to a regional scale, greatly increasing confidence in attribution to human causes. Through this EXTREME project, I will increase my research skills, but also gain adequate soft skills in project management, supervision and dissemination with the ultimate intent to build a vibrant research group in Europe.

Mots clés : heat and cold wave temperature extreme extreme event attribution regional climate change and variability global warming land use cover change weather research and forecasting model, wrf cmip6

Participants :
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet RS SILENCE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Silence shouts, as the Romans recognised. Silence and absence are communicative strategies which are deployed and interpreted by actors and audiences according to the participatory expectations of a given field. This project is the first major study of silence and absence as communicative strategies in the Roman World. It focuses on members of the senatorial elite (including the women of senatorial families), who were highly skilful, creative, and influential actors in and interpreters of political culture, and it analyses the significance of their deployment of silence and absence as communicative strategies in the transition from the participatory system of the Republic to the autocracy of the Principate. The method encompasses the survey and analysis of textual material of various genres from the first century BCE – first century CE, with a particular focus on the relationship between the constructions of gender and of authority. This novel project will expand understanding of the performance dynamics of Roman politics and the frequency and significance of silence and absence as strategies within it. The larger issues of agency, participation, freedom, and resistance which the project addresses are pertinent now in light of the rise of the ‘new demagogues’ and the challenges facing contemporary democracies.

Mots clés : roman history, classics, political history, gender

Participants :
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet T2D-EOMICS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

In this project, I will develop methods to simultaneously measure transcriptomes with single-cell resolution and perform high-throughput functional measurements of individual pancreatic islet cells. I will focus on β- and α-cells which regulate glucose levels by secreting the two main glucoregulatory hormones -insulin and glucagon- and whose dysfunction is associated with diabetes. The islet is a highly heterogenous mini-organ, making it an ideal tissue to study the relationship between molecular and functional heterogeneity. It has been recently developed the use of patch-clamp electrophysiology and single-cell RNA sequencing (patch-seq) using whole-cell electrophysiology. In this work, I will combine high-density microelectrode array technology (HD-MEA) and transcriptomic methods to identify changes that lead to dysfunctional cellular states in type 2 diabetes. To do so, I will build a cell cherry-picking system to perform single-cell RNA sequencing after electrophysiological measurements in the same islet cell. Then I will use this system to investigate subpopulations of α- and β-cells that have been previously identified in human islets from donors with type 2 diabetes using transcriptomic methods, but whose implications in cell and tissue function are yet unclear.

Mots clés : electrophysiology, diabetes, single cell, islet cells

Participants :
- Chan zuckerberg biohub sf llc (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet LIME (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

Atom-photon interactions are one of the most studied interactions in physics. These interactions are critical to the realization of several quantum technologies and the investigation of fundamental phenomena in many-body quantum physics. Yet controlling them at the quantum level in an efficient way is still one of the central challenges in contemporary physics. Subwavelength atomic arrays are emerging as a novel paradigm to realize efficient atoms-photons interactions. They are periodic arrangements of atoms with an interatomic separation smaller than their dipole transition wavelength. Atomic arrays harness dissipation as a resource, improving the control of atom-photon interactions over standard light-matter interfaces. However, most of the current theoretical and experimental effort has been devoted to the single excitation response of atomic arrays, thus neglecting the role of quantum correlations. Exploring these effects is timely as several experiments with subwavelength arrays can access this uncharted domain. This project aims at investigating the correlated many-body dynamics of subwavelength arrays and at studying their potential application in quantum technologies. Combining the fellow expertise in optomechanics, the US Host's deep knowledge of subwavelength arrays and open systems, and the EU Host's mastery of numerical methods for many-body physics, the goal of this research proposal is to establish subwavelength atomic arrays as efficient atom-photon interfaces and carefully model their experimental realization with atoms in optical lattices.

Mots clés : open quantum systems, optomechanics, many body physics

Participants :
- Université Columbia (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 261380.64 €
Projet EXOFUN (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Over the centuries, exotic trees have been planted worldwide for the rehabilitation of degraded lands and to obtain financial benefits from wood, paper production, tannins, ornamental assets. However, despite being evolutionary naïve to the new environment outcompete the locally adapted native plants in resource acquisition, displace the native vegetation and may become invasive species. While the influence of exotic plantations on native vegetation structure and community composition is well documented, surprisingly, much less is known about how exotic tree plantations have altered the structure and function of the soil microbiome. Although soil conservation is integral for the achievement of socio-ecological sustainability, a comprehensive study focused on the biogeographical comparisons of cyclic linkages between exotic plants and soil microbes and its influence on the multiple ecosystem functions is lacking. This is urgently needed to better understand the impacts of exotic plantations on biodiversity and function along with interaction with other global change drivers such as climate change. Using Eucalyptus globulis and Pinus pinea as our model exotic tree species, the main aim of EXOFUN is to understand the influence of exotic plantations on the structure and function of the soil microbiome at a cross-continental scale by combining observational studies and greenhouse experiments. How do exotic tree plantations influence carbon sequestration, soil biodiversity maintenance, and the capacity of ecosystems to response to climate change compared with native forests? In the current UN-decade of ecosystem restoration, the outcomes of this project will help to understand that to what extent the plantation of the exotic species be allowed, or should we completely replace it with native plants to maximize the ecosystem services. The outcome will also contribute to the European mission (soil deal for Europe) to protect and restore soil across Europe by 2030.

Mots clés : soil ecology, invasion, microbiome, ecosystem multifunctionality, climate change, restoration

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet Foraminiferal aliens (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

FORALIEN (FORaminifera ALIEN) is a project aiming to fill the lack of knowledge of non-indigenous (i.e. alien) benthic foraminifera (marine protists) observed recently in Europe to make them a reliable indicator of human impacts for a better integration into biomonitoring surveys in the context of the European regulation of the Marine Framework Strategy Directive. To do so, I plan to sample surface sediment and sediment cores of several sites on the West Swedish coast which are composed of understudied harbours, in terms of foraminifera but known places of pollution and introduction, and fjords where some have been recently observed, such asTrochammina hadai and Nonionella sp. T1. Among those NIS, Ammonia confertitesta could also occur there. This species has been recently identified as a pseudo-cryptic species included in the Ammonia tepida morphotype with two other very morphologically similar species, A. aberdoveyensis and A. veneta, that are native species in Europe. In a first place, I will morphologically identify these NIS by defining easy criteria of identification and apply a recently developped method allowing an easy identification of the three species of the A. tepida morphotype. To complement the morphological method I will apply novel methods, genetic (digital Polymerase Chain Reaction) and deep learning models, to identify NIS foraminifera quickly and reliably assess their efficiency in biomonitoring surveys. Secondly, I will use methods precedingly described and sediment samples to analyse the spatio-temporal distribution and time of arrival of NIS in the region. This would result in the development of a NIS index to asses their impact on native species. Finally, environmental parameters will be measured to define the unknown ecological requirements of NIS to better integrate them in traditional foraminiferal biotic indices used to assess the health of ecosystems and to explain and forecast their possible succesful invasions in Sweden.

Mots clés : non indigenous species, benthic foraminifera, identification methods, bio invasions, ecological requirements, biotic indices

Participants :
- Université de Stockholm (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Göteborg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €