Projet MASSTRPLAN (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : CLOSED

MASSTRPLAN will train the next generation of interdisciplinary research leaders in advanced molecular analytical techniques to detect oxidized phospholipids & proteins in biological & clinical samples, evaluate their biochemical roles in inflammation, and translate these findings to develop new diagnostic tools. Chronic inflammatory diseases such as diabetes, cardiovascular disease (CVD) & cancer are major causes of mortality and cost the EU economy dearly in healthcare and lost working time; CVD alone is estimated to be responsible for 47% of deaths and to cost the EU €196 billion a year. Scientists able to develop advanced analytical tools for detecting oxidative biomolecule modifications and assessing their contribution to cell dysfunction & disease are urgently needed. The objectives of MASSTRPLAN are to 1) train early stage researchers (ESRs) in advanced and novel chromatography, mass spectrometry, and complementary techniques including microscopy and bioinformatics to detect challenging heterogeneous biomolecule modifications and determine their functional effects; 2) give ESRs a broad perspective on relevance & mechanisms of oxidative modifications in pathophysiology and biotechnology; 3) enable ESRs trained in technology development to engage effectively with the clinical sector; and 4) train ESRs in translational and development skills to produce new protocols, materials and commercializable diagnostic tools. The ETN will achieve this by bringing together 10 beneficiaries and 15 partners from academic, industrial and healthcare organizations working in analytical, bioinformatic, biological, clinical & biotech fields to provide multidisciplinary, cross-sector training. Extensive mobility, industrial secondments and network-wide training will yield a cohort of analytical scientists with the unique theoretical, technological, and entrepreneurial skill set to yield new understanding of oxidative inflammatory disorders, leading to better tools and therapies.

Mots clés : lipid oxidation, oxidative post translational modifications, lipoxidation, inflammation, diagnostic tools

Participants :
- Leipzig University (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 498432.96 €
- University Hospital Leipzig (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Thermo Fisher Scientific (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- Achucarro basque center for neurosc (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- European proteomics association (Allemagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Red española de microscopía óptica (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Vlaams Instituut voor Biotechnologie (Belgique) — Partner, beneficiary, Recherche, subvention : 250560.0 €
- Hospitais da Universidade de Coimbra (Portugal) — Partner, beneficiary, Autres, subvention : 238356.36 €
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 546575.76 €
- Centro Hospitalar do Baixo Vouga (Portugal) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Instituto portugues do sangue e da transplantacao ip (Portugal) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Cell2b advanced therapeutics sa (Portugal) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 258061.32 €
- Spanish National Research Council (Espagne) — Partner, beneficiary, Recherche, subvention : 495745.92 €
- Antec leyden bv (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- RELX Group (Netherlands) (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Cayman Chemical (United States) (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Aveiro (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 476712.72 €
- Ab sciex uk limited (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Waters (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Milan (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- DSM (Switzerland) (Suisse) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- DSM (Netherlands) (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Society for free radical research europe (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Unicam sistemas analiticos (Portugal) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Mologic (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 273287.88 €