Projet Keep Control (Horizon 2020, appel à projets 2016)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

Balance and gait deficits are ubiquitous among the older population, and lead to enormous personal, occupational and health care burden. Emerging pharmacological and non-pharmacological interventions to date have only small to moderate effects on these deficits. This is likely due to remaining fundamental questions on underlying mechanisms and treatment. The present project Keep Control consists of a rare EU-wide combination of experts from clinical, biomechanic and neuroscience research, along with experts from the industry, who all aim at gaining a better understanding and treatment of balance and gait deficits in older adults. We aim to scrutinize aspects such as: (1) comparability of balance and gait assessment in the clinic and the home environment, (2) gait and balance deficits as prodromal markers of neurodegeneration, and as markers to differentiate between Parkinsonian syndromes, (3) association between freezing of gait and balance, and (iv) gait and balance deficits in patients with sarcopenia. Tools such as sophisticated lab-based gait and balance assessment devices, perturbation treadmill, wearable devices, electrophysiology and blood and tissue investigations will be implemented. We will further employ promising therapeutic strategies for specific gait and balance deficits in older adults, including both pharmacologic and non-pharmacologic strategies. An entire work package will be dedicated to a novel harmonization and integration approach across the whole network: It will (i) harmonize assessment protocols based on the WHO definition of health and disability, to pave the way for an exhaustive meta-analysis of all data collected, and (ii) foster the active involvement of all study participants by implementation of a participant-controlled medical record. In summary, Keep control will cover the entire range of expertise necessary and utilize cutting edge technology to educate fellows in the area of gait and balance deficits in older adults.

Mots clés : international framework of functioning, disability and health  icf model, sarcopenia, peripheral neuropathy, frailty, neurodegeneration, prediction, balance and gait, falls, biomechanics

Participants :
- Kiel University (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 436128.84 €
- Centre hospitalier régional universitaire de Lille (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262875.6 €
- Motek medical bv (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 255374.28 €
- Hasomed (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 249216.48 €
- KU Leuven (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 250560.0 €
- Gait up sa (Suisse) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 265226.76 €
- University of Porto (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 238356.36 €
- Patients know best limited (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 68321.97 €
- University Medical Center Groningen (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255374.28 €
- Ludwig-Maximilians-Universität München (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 249216.48 €
- Newcastle University (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- Vrije Universiteit Amsterdam (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255374.28 €