Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet TransMemo (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Recently, migration has emerged as one of the most serious challenges for society, not only in Europe but also globally. As migration occurs in many cases cross-linguistically and cross-culturally, the migrant is not only torn between two lives and two places, but also between different languages, cultures and identities, bringing to the fore the role of translation as process of recall. While research on translation and memory in migration contexts has emphasized translation as intergenerational transmitter of memory, little attention has been paid to the personal dimension of memory. The proposed research aims at developing a new theory for the translation-memory interface. Drawing on current research in the philosophy of mind, it will analyze the relationship between autobiographic memory and translation, emphasizing the emotional dimension of memory as experience of the body and interaction between people, while at the same time highlighting the role of forgetting. This will be supported by a number of case studies on autobiographic memory in migrant Arab authors in Britain and the US, using the concept of cultural translation. Thus, the project will encourage interdisciplinarity and open new perspectives for research by applying memory concepts to translation and offering a theoretical framework that departs from the traditional, representational paradigm and foregrounds memory as embodied action. In this way, the project will contribute to a better understanding not only of how translation and memory interact, but also of how migration itself as translational experience takes place and what motivates migrants in their continuous quest for and struggle with memory. The action involves a two-way transfer of knowledge backed by a professional training and development plan, including training-through-research, project management, dissemination and communication activities, publications and conferences, teaching and pedagogy, as well as mobility and networks.

Mots clés : translation, translation theory, philosophy of mind, memory, autobiographic memory, remembering and forgetting, contemporary arab migrant literature, cultural translation

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet REPTIMORG (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Replication timing is observed in all eukaryotes analyzed so far suggesting an important and conserved function. Despite significant advancement in the field, the molecular control of the replication-timing program is still largely unknown. The Buonomo laboratory has recently done very innovative work in this area. After identifying Rif1 as the only known global regulator of replication timing in mammalian cells, they have further shown that Rif1 controls chromatin architecture during replication-timing establishment. This provided the first molecular evidence linking 3D nuclear organization and replication-timing control. However, Rif1 is a complex protein whose structure-function is not fully understood and it is not clear yet if the link between 3D nuclear organization and replication-timing control is specific to Rif1 or a general paradigm. A major aim of this proposal is to investigate if chromatin architecture plays a general role in replication-timing control. To this end, I will perform replication-timing and chromosome-conformation studies using mouse models which allows me to conditionally delete genes encoding for key regulator of nuclear structure, such as cohesin (Rad21) and Lamin B1. I aim with this proposal to advance the understanding of how spatial organization of chromatin regulates and integrates different nuclear functions, with a specific focus on DNA replication.

Mots clés : nuclear organization, chromatin, dna replication

Participants :
- University of Edinburgh (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet CLASSy Aging (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Research has consistently demonstrated that older adults have difficulties consolidating recently learned movements into robust motor memories. This impairment undoubtedly contributes to the movement deficits emerging with healthy aging and hinders rehabilitative strategies. As consolidation is known to be facilitated by sleep, these movement-related deficits partially result from age-associated degradations in sleep characteristics. Accordingly, the project CLASSy Aging (Closed-Loop Acoustic Stimulation during Sleep to enhance motor memory consolidation in Aging) aims to optimize sleep-related motor memory consolidation in healthy older adults. Specifically, during a post-learning nap, I will use forefront real-time electroencephalographic (EEG) analyses to reactivate memories via Targeted Memory Reactivation time-locked to neuroplasticity-related physiological events of interest (i.e., sleep spindles and slow oscillations). This project will use a novel and sophisticated approach designed to boost sleep-dependent consolidation and minimize previously observed aging-related deficits. I will unravel the neural correlates of the memory reactivation process using high-density EEG during post-learning sleep and the stimulation-enhanced neuroplasticity processes during task practice using functional Magnetic Resonance Imaging (MRI). This project uses a comprehensive approach as the brain will be imaged at different phases of the memory formation (i.e., learning, consolidation and retest) making use of cutting-edge neuroimaging analyses (univariate and multivariate MRI analyses, sources localization of hdEEG signal) tailored to each of these phases. This ambitious, yet feasible, multimodal neuroimaging project will provide significant insights into motor memory processes. It will offer new avenues to amplify neuroplasticity, alleviate motor deficits, and increase well-being in not only healthy aging, but ultimately in those with neurological conditions.

Mots clés : aging, sleep, targeted memory reactivation, closed loop stimulation, motor memory consolidation, magnetic resonance imaging, high density electroencephalography

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166320.0 €
Projet MathInGreaterParis (Horizon 2020, appel à projets 2020)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

Research in mathematical sciences plays a key role in competitivity and growth, and in facing new challenges as numerous future technologies and complex societal questions are relaying on advances in mathematics. France has a long tradition of excellence in mathematics research and education, and Greater Paris Region represents the largest concentration of mathematicians in the world, with incredible successes. However, the Region still suffers from a relative dispersion. The Greater Paris’ mathematical community, namely FSMP (Fondation Sciences Mathématiques de Paris covering all laboratories in Center/North of Paris), FMJH (Fondation Jacques Hadamard in Paris South) and Fédération Bézout (in Paris East), have decided to join forces in the present ambitious Cofund MathInGreaterParis Fellowship Programme. The 60-month project is split over 3 calls of 2-year fellowships, offering a total of 74 years of fellowships. The MathInGreaterParis objective, as a single and unified portal to Greater Paris Region, is to attract the brightest Experienced Researchers in mathematical sciences. The training activities will focus on: 1) Research, transferable skills and career development, 2) International, interdisciplinary and intersectoral secondments in research and/or teaching, 3) Wider impact of research concentrating on competitivity and outreach. They will be helped in building their future, whether in the academia or towards new industrial challenges. They will be taught how to communicate with society and become truly “Math Ambassadors”, based on “learning by doing approach”. MathInGreaterParis fellows will emerge new ambitions, educate a mindset oriented towards more mobility and curiosity, a greater awareness of the mathematics’ impact in the new economy, a greater taste for risk, innovation and entrepreneurship. This will yield in regional, national and international socio-economic benefits and strengthened human resources.

Mots clés : postdoctoral fellowships in mathematics in its wide sense, in paris region

Participants :
- Fondation sciences mathématiques de Paris (France) — Coordinator, beneficiary, Recherche, subvention : 2721720.0 €
Projet ILTIS (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Research on infectious diseases has high priority for the scientific and medical communities worldwide, to tackle the alarming spread of multidrug resistant bacteria and to fight and prevent virus outbreaks. On the French island of La Réunion, infections such as leptospirosis and chikungunya pose considerable threats for public health. My career aspiration is to establish myself as a clinical scientist in the field of immunology of microbial infections, especially in severe conditions such as septic shock and leptospirosis. I am also interested in deciphering the emerging role of host cell-derived factors (HSDF) in shaping the innate immune response. The immune response to pathogens and HSDF involves numerous cell types and soluble factors such as cytokines but remains ill-characterized. A better understanding of the cellular and molecular signatures in acute disease may pave the way to better and earlier diagnosis, targeted treatment and improved outcomes. The aim of the proposed study is to study the phenotype and function of innate immune cells during sepsis, with a particular focus on γδ T-cells, neutrophils and monocytes. This translational research involves bed to bench-side approaches (clinical investigations on septic shock during community-acquired pneumonia) and in vitro studies in cell culture, by analysing cell viability and activation as well as key cellular functions such as cytokine release, phagocytosis and antigen presentation in relation to the causative pathogen. I am keen to link this project with my previous studies on immune-mediated cell death during septic shock and on the early immune response to leptospirosis. The possibility to join the internationally renowned immunology teams at Cardiff University will be of great benefit to my research and will allow me to further my skills and expertise as well as create a network of productive collaborations for my future career when returning to Reunion.

Mots clés : innate immunity, sepsis, septic shock, pneumonia

Participants :
- Cardiff University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 97727.4 €
Projet GNeuS (Horizon 2020, appel à projets 2020)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

Research with neutrons, with its interdisciplinary approach, is indispensable for modern science. Taking into consideration tremendous changes in the European neutron landscape and assuming responsibility for sustainability, the neutron community is nowadays facing an important task to ensure long-term perspectives, that essentially depend on its ability to create a new generation of innovative highly-skilled researchers. To tackle this challenge, Forschungszentrum Juelich (FZJ), Technical University Munich (TUM) and Helmholtz Zentrum Geesthacht (HZG), partners at the Heinz-Maier-Leibnitz Zentrum (MLZ), will train young neutron scientists through the establishment of a well-structured post-doctoral research programme with a strong interdisciplinary and intersectoral approach and global outreach. Responding to the recommendation of the ESFRI Innovation Working Group Report (March 2016), "for moving into the era of global thinking for neutron sources", the Global Neutron Scientists (GNeuS) programme will be implemented as a global network in cooperation with world-leading neutron sources aiming to create a community of neutron experts able to use future facilities such as the European Spallation Source (ESS). In order to maximize the outcome for fellows, the three MLZ partners will join forces with 19 partner organisations from around the world representing research, academia and industry. The GNeuS programme will provide the best conditions for training of the next generation of neutron researchers to solving the grand challenges facing mankind in areas such as environment, energy, key technologies and life sciences. This 5-year programme will offer a total of 45 fellowships each with a duration of 24 months. The MLZ-partners FZJ, TUM and HZG will act as hiring organisations. The non-hiring partner organisations will provide fellows with options for secondments. Furthermore, we expect added value through synergies with the active COFUND DP InnovationXN programme.

Mots clés : global, postdocs, neutron, intersectorality, inter disciplinary

Participants :
- Forschungszentrum Jülich (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 3310200.0 €
Projet DELLATECH (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Since their discovery, the plant hormones gibberellins (GAs) and their inhibitors have become a widely used tool to improve very diverse agronomical aspects, such as the size and productivity of grasses, horticultural species and ornamental plants. However, indiscriminate application of these compounds also provokes undesired secondary effects. For instance, GA application is used in agriculture to promote and synchronize fruit development, but it weakens the defense mechanisms against pests. Therefore, there is a serious need to find new GA-related biotechnological tools that specifically improve certain agronomical traits without the lateral effects. Based on the deep knowledge generated about GA signaling in the past 20 years with the help of our own lab, here we propose to (1) establish a method to generate plant varieties that specifically improve certain GA-related traits without the lateral effects; (2) search for compounds that specifically mimic certain aspects of GA signaling; and (3) in conjunction with a Spanish biotech company, provide a well-trained academic scientist with the capacities needed to develop a professional career within industry-oriented biotechnological research.

Mots clés : gibberellins, proof of concept, growth vs stress responses, chemical genetics

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 170121.6 €
Projet SPIRAL (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Single photon sources are essential for applications of quantum optics. For optical quantum computing the process is probabilistic and so the larger the number of photons the less time required for success. Therefore, there has been a push to increase the brightness of single photons sources. This goal of this action is to develop a source of heralded single photons with a very high spectral brightness, based on four-wave mixing in an alkali-vapour contained in a hollow core photonic crystal fibre. This will exploit the higher efficiency expected from using a hollow core fibre to boost the brightness of the single-photon source. Also, by using optical fibre technology, this photon source should be very simple to integrate into other systems. Once the photon pairs are generated, the major challenge of this system will be to split them from themselves, as well as removing the vast number of remaining pump photons. Since all three wavelengths of the light emerging from the fibre are very close to each other, and the beams are spatially overlapped, many common techniques (such as using interference filters and/or spatial filtering) will not work. However, we have identified a scheme using an atomic Faraday filter which will allow a beam splitter to be formed for the photon pairs, whilst simultaneously removing the pump photons.

Mots clés : single photons, quantum optics, magneto optical effects, faraday effect, fadof, hollow core fibre, atomic physics

Participants :
- University of Stuttgart (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 132884.0 €
Projet DEMONS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Single-photon sources are quantum light sources that, when triggered, emit deterministically a single photon and are therefore highly desired in many applications such as quantum imaging, sensing and in information processing. Hence, single photon sources have been an ongoing subject to research for many decades and nowadays even a few start-up companies offer single photon sources. However, for many applications on-demand single photon emission is not sufficient, but deterministic N-photon sources are required that emit exactly N photons with N≥2. These novel N-photon sources do not exist yet but have a broad range of applications, including applications in quantum metrology and lithography, the production of NOON-states for quantum information processing, superresolution microscopy and even medical imaging applications. In the action “DEMONS” we will realize a high-fidelity N-photon quantum light source at the Max Planck Institute for the Science of Light (MPL). More precisely, we will utilize light–matter interactions between molecules and an open scannable and tuneable microcavity at cryogenic temperature to create exotic quantum states that will emit multiphoton quantum light. To do so, we will start with the Fabry-Pérot open microcavity developed at MPL and improve its design for the purpose of this action. Afterwards, we will examine two complementary approaches to create a N-photon quantum light source: In the first approach we will use cooperative coupling of N emitters via the common light field of the microcavity, whereas in the second approach, we will exploit the nonlinearity of the strongly coupled single molecule-microcavity system and create a photon blockade to generate deterministic emission of N-photon bundles. The successful outcome of this action will be the first experimental realization of a high-fidelity N-photon emitter and is expected to boost research in various interdisciplinary areas from bio-imaging to photonic quantum simulation.

Mots clés : quantum emitters, molecules, spectroscopy, microcavity, strong coupling

Participants :
- Max Planck Society (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 174806.4 €
Projet SEX_FIGHT_SLEEP (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Sleep is a fascinating phenomenon and one of the least understood mysteries of biology. It is universal among the animal kingdom and most species devote a large part of their day to sleep, despite the risks of lowering their defenses against predators or not engaging in more productive activities such as foraging or mating. In many animals, social interaction is a powerful modulator of sleep quality and quantity. In nature, animals are continuously exposed to a diverse variety of stimuli, and interactions with con-specifics represent a particularly relevant set of them. For Drosophila males, interaction with females is key to ensure reproduction, while interaction with other males can create antagonistic fights to compete for sexual partners, food or shelter. Through this project, I propose to investigate if and how social interactions affect sleep need and sleep quality. Employing fruit flies it has been previously shown that male-male interaction during the night builds up sleep pressure, observable in the next day as marked increase in sleep. Recovery of sleep after sleep deprivation is also called “sleep rebound”, and in all species it is thought to be 1) at the basis of sleep homeostasis and 2) positively correlate with sleep deprivation. The longer an animal stay awake, the higher the sleep pressure and following rebound. Also, it has been described that previous sleep experience modulates antagonistic behaviours between males. Thus, bidirectional interplay between social interaction and sleep appears as a promising framework to address a main goal of modern neuroscience, understand how sleep is regulated and which sleep functions are. I intend to use new developed behavioural paradigms and software that improve sleep analysis in combination with refined genetic tools available in Drosophila to extend our knowledge on the interaction between phylogenetically conserved behaviours, social interactions and sleep, which have a high impact on reproductive fitness.

Mots clés : sleep, courtship, aggression, drosophila, sleep deprivation, pheromones, neural circuits

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet TRAINEd (Horizon 2020, appel à projets 2017)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

TRAIN@Ed is a research fellowship programme for 25 experienced researchers (around 4 -6 years after gaining their primary degree) which will provide researchers with an international, interdisciplinary and intersectoral mobility experience. The TRAIN@Ed programme will educate experienced researchers in research excellence AND transferrable skills. TRAIN@Ed Fellows will have an employment contract with the University of Edinburgh for a research fellowship for up to three years. TRAIN@Ed fellows will pursue research and transferrable skill training at the University of Edinburgh, and will also spend some time in the industry of their choice. At the end of the TRAIN@Ed programme, TRAIN@Ed alumni will have the knowledge, skills and experience for fulfilling and productive careers either in academia OR in industry. The values of the scheme align with those held by Horizon 2020: Excellent Sciences, Industrial Leadership and addressing Societal Challenges, and the Marie-Skłodowska Curie Actions of providing excellent, innovative research training and career progressive and knowledge exchange and mobility opportunities. Although the focus of the TRAIN@Ed programme is in developing research skills through carrying out a research project, a holistic approach to career development of the researchers will be taken: the programme will provide mentoring, transferrable skill development (including public engagement training), and careers advice. TRAIN@Ed delivers in important areas of experienced researcher development in the European Union: Firstly, it provides a highly visible research opportunity for experienced researchers, with secure employment for three years. Secondly TRAIN@Ed addresses a major gap in opportunities for early career researchers to collaborate with industry. Thirdly, TRAIN@Ed complies with best practice in supporting researcher careers. TRAIN@Ed will benefit the researchers, the University of Edinburgh and the European economy.

Mots clés : post doctoral training, global health and wellbeing, global energy, data science, arts and design informatics, ageing and regeneration, city living and smart cities

Participants :
- University of Edinburgh (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 2655000.0 €