Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet EARLINESS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Systemic lupus erythematosus (SLE) is a systemic autoimmune connective disease in which the immune system attacks its own structures, causing widespread inflammation and tissue damage in the affected organs. The kidney is one of the main organs affected by SLE, and lupus nephritis (LN) concerns 30–60% of adult SLE patients, being significantly associated with an increase in morbidity and mortality. The definitive diagnosis of LN can only be achieved by histological analysis of renal biopsies, but the invasiveness of this technique is an obstacle for early diagnosis of renal involvement and a proper follow-up of LN patients under treatment. Our aim to identify minimally invasive biomarkers of renal involvement and non-response to therapy in SLE using body fluid (urine and blood), using cutting-edge technologies related with flow cytometry: blood mass cytometry, urinary inflammatory mediators, extracellular vesicle analysis and urinary microbiome. The tissue/fluid correlation will be assessed using kidney biopsy samples following a liquid biopsy approach. We will apply this analysis to longitudinal samples of LN patients recruited in 3TR consortium, and finally design a prototype kit for LN diagnosis and prognosis. With this project EARLINESS participate in the efforts of the scientific community to develop effective strategies for personalized rheumatology.

Mots clés : non invasive biomarkers systemic lupus erythematosus nephritis extracellular vesicles inflammation precision rheumatology

Participants :
- Atrys health, sa (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Fundación Progreso y Salud (Espagne) — Coordinator, beneficiary, Recherche, subvention : 226441.2 €
Projet CHORA (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In today's highly digitized, post-COVID world, where virtual interactions often replace human-to-human contact, society faces a critical challenge: the increasing disconnection from our bodies and a decline in direct human sensory experiences. This virtual disembodiment diminishes our capacity for empathy, emotional engagement, and social adaptability, weakening our collective ability to build healthier, more inclusive communities. To counter these trends, and in alignment with Horizon Europe’s 2023-25 focus on human-centred practices, we must promote shared, embodied experiences that primarily engage our senses and emotions. The performing arts, with their emphasis on physical expression, offer an ideal platform for fostering such engagements. The CHORA project aims to confront this issue by developing the Choreographic Approach (CA), an innovative training and teaching methodology for the performing arts, designed to promote human-centred, embodied learning in both academic and non-institutional settings. Leveraging the unique potential of the performing arts sector to engage people through shared sensory experiences, the CA integrates sound, voice, and movement into interdisciplinary exercises that foster creative, collaborative, and non-hierarchical practices. It provides a toolkit for sensory-based creation and interpretation, offering an accessible and adaptable framework for diverse educational settings. Conducted through practice-as-research (PaR) activities at the Department of Drama, Trinity College Dublin (host institution), the Department of Communications, Drama and Film, University of Exeter (secondment host), and the Nordisk Theaterlaboratorium, Hostelbro, Denmark (non-academic placement), the CHORA project will produce a practical training tool applicable across arts education, community engagement, and well-being programs.

Mots clés : performance training, education, embodied research, physical theatre, musicology, interdisciplinary practice, practice as research, collaboration, voice studies, sound studies, somatic training

Participants :
- Université d'Exeter (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Nordisk teaterlaboratorium (Danemark) — Partner, associated partner, Autres, subvention : 0.0 €
- Trinity College (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 315910.8 €
Projet CalSAF (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Wet waste and long-distance travel are unavoidable consequences of wealthier societies; unfortunately, they both contribute to climate change. Hydrothermal liquefaction (HTL) and biocrude hydrotreating (HT) can convert wet wastes into sustainable aviation fuels (SAF), but for this to become a reality, some pressing challenges need to be addressed. CalSAF is Dr. Matteo Pecchi’s career development program, designed to develop differential scanning calorimetry (DSC) methods that can provide high-resolution information on the HTL and HT process development in-situ, at a fraction of the cost of traditional methods using batch reactors and chemical analyses.  Dr. Pecchi’s training is supported by an international collaboration of world-leading universities and experts in the hydrothermal field, leveraging their cutting-edge experience and equipment. This collaboration aims to facilitate his transition into an independent researcher and expert in thermochemical processes for waste valorisation, which is central to his long-term career goals.  If successful, CalSAF will uncover new insights into the mechanisms and kinetics of HTL and HT, addressing key challenges that currently hinder industrial SAF production from wet waste. These challenges include the high costs and time associated with HTL screening campaigns and the lack of data for effective control to prevent clogging in HT reactors. The impact on both waste management and fuel production sectors will generate significant environmental, social, and economic benefits, including reducing emissions, decreasing pollution and health risks, and opening a potentially multi-million-euro market.

Mots clés : hydrothermal liquefaction, hydrotreating, sewage sludge, waste recovery, kinetics, chemical mechanism, differential scanning calorimetry, biocrude

Participants :
- Université d'Aalborg (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université libre de Bolzano (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet STARDAM (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Spin Transport and Relaxation Dynamics in Single-Molecule Junctions (STARDSMJ) aims at developing a toolbox of computational methods to study spin relaxation of molecular nanomagnets in the presence of charge fluctuations and external bias. This will allow us to investigate the factors affecting the spin relaxation in molecular magnets in realistic environments, namely in the operational conditions of nanoscale devices. Density Functional Theory combined with non-equilibrium Green's functions (NEGF) theory is the ab initio workhorse method for electron transport calculations. This, however, is limited to scattering from a static potential, while dynamical effects are typically included through appropriate self-energies in a perturbative way. In contrast, spin relaxation can be investigated by propagating in time master equations with parameters extracted from accurate electronic structure theory. In this case the molecule remains in a single charging state and inter-molecular interactions are of dipole-dipole nature. The main goal of STARDAM is to construct a formalism that can capture spin relaxation in an environment with fluctuating number of electrons, namely going beyond and unifying the two approaches. I will achieve this goal by developing and applying a robust theoretical scheme to solve the master equation for the transport of single-molecule junctions, where various effective spin Hamiltonians, extracted from first-principles calculations, will be used to describe the molecule.

Mots clés : molecular spintronics, molecular nanomagnets, spin phonon relaxation, quantum transport theory, molecular nanomagnets at the interface, spin relaxation

Participants :
- Trinity College (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252728.64 €
Projet PalSol (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This project studies the shifting trajectory of pro-Palestinian activism in West Germany, between the 1950s and 1980s. At its center is the question of how we can explain that contemporaries in West Germany began to support Palestinian politics and later withdrew their solidarity. In order to answer this question, the project will study for the first time Palestinian and German archives together. With this approach, it proposes a new focus on the role of migration and ties to the Middle East for solidarity politics in the West German left.  The reasons for the rise of Palestine solidarity movements during the 1960s and their decline in the 1980s are a much-discussed topic in the history of the Western European left. With the legacy of the Holocaust and an earlier support for Israel in the West German left, this trajectory is particularly puzzling in the case of the Federal Republic. Historians have sought to explain this puzzle by focusing on continuities in the history of Antisemitism and a changed perception of Israel after the Six-Day War of 1967.  PalSol breaks new ground by studying Palestinian sources on the solidarity movement in West Germany. These sources provide a fresh vista on everyday interactions and the role of the Palestinian diaspora in bridging leftist politics between places like Beirut and Bonn. Pursuing a transregional approach, the project promises to shed light on how political struggles in Europe and the Middle East became integrated and disintegrated between the 1950s and 1980s

Mots clés : german history, palestinian history, european history, history of the middle east, history of the left, transregional history, migration history, oral history

Participants :
- Université de Roskilde (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet PRODAPTIVE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Humans typically possess the ability to communicate effortlessly through speech, alternating between speech production and perception. A critical skill for effective communication is the ability to adapt speech to acoustic environments (e.g., noise). Such speech adjustments are often involuntary and exemplified by phenomena like the Lombard effect, where speakers in noisy environments naturally enhance speech clarity by exaggerating word pronunciation (acoustic measures). On the other hand, individuals exhibit variability in their speech adaptation abilities, with those with lower adaptation abilities experiencing reduced communication effectiveness. Previous studies have shown that speech adaptation promotes listeners' speech perception. But the relationship between an individual's adaptation ability and their own speech perception skills is still unclear. I hypothesize that individuals who are proficient in speech adaptation are also better at perceiving others' speech. I assume that speech production and perception processes are integrally connected within the same individuals but the precise mechanisms linking these processes remain elusive. This project aims to bridge this knowledge gap by exploring the link between acoustic measures of speech production adaptation and neurophysiology of speech perception. Experimental work will pioneer the integrated study of behavioural measures with neurophysiological techniques, such as electroencephalography (EEG), to study the real-time dynamics of speech communication during live interactions. I will investigate whether acoustic measures serve as indicators of individual differences in speech perception abilities. I will leverage cutting-edge analysis techniques that allow the investigation of neural responses to continuous adapted speech. This project will provide novel insights into the dynamics of speech communication and advance the understanding of the aetiology of speech perception and production issues.

Mots clés : speech production, speech perception, eeg, trf, phonetics, cerebral cortex

Participants :
- Trinity College (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252728.64 €
Projet ModIX (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The role that ill health plays in thematic concerns of modernist literature has been a topic of scholarly interest in recent years. Less considered, however, is the relationship between ill health and modernist practices of writing. The primary research aims of ModIX are to provide a sound methodology for exploring this relationship and to define modernist writing strategies and accommodations as they relate to authors’ illness experiences. Methodologically innovative, ModIX applies affect theory to genetic criticism in order to trace the author’s body as a tool and facilitator of writing. The project focuses on three key modernist authors who experienced illness to a life-altering degree: James Joyce (1882-1941), D. H. Lawrence (1885-1930) and Katherine Mansfield (1888-1923). Drawing together insights from affect theory, health humanities and archival studies, ModIX will reconstruct the literary geneses of Joyce’s Finnegans Wake, Lawrence’s Lady Chatterley’s Lover and selected short stories by Katherine Mansfield, all written during periods of the authors’ ill health and needs for care. ModIX’s research objectives are to consolidate affective genetic criticism as a methodology, to understand modernist illness experience phenomenologically, and to reconstruct the networks of care that surrounded these modernists as a result of ill health and creative needs. ModIX goes beyond the state of the art to understand the lived experience of illness not only as a biographical fact, but as a dynamic, material factor in shaping, facilitating and sometimes frustrating modernist literary labour and production. ModIX is an archival project that will produce original and impactful results. The project outputs will include three peer-reviewed articles in high quality journals, a monograph proposal, and a research summit to form the basis for a large-scale interdisciplinary ERC project on illness experience and literary production.

Mots clés : genetic criticism, affect theory, health humanities

Participants :
- Université de Loughborough (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet ENVISAGE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Human endogenous retroviruses (HERV) are highly repetitive sequences that are remnants of viral infections successfully integrated in the genome. Aberrant expression of HERV envelope (Env) proteins is frequent in cancer, autoimmunity, neurodegeneration, and infection and has been associated with antibody responses. However, we do not know if all HERV Env proteins contribute to antibody responses or what the prognostic impact of HERV Env-specific antibodies is. Thus, the objectives of this proposal are to i) implement a high-throughput screening platform for HERV Env-specific antibodies and ii) develop a bioinformatics approach to identify the HERV insertions producing Env proteins. To achieve these goals, HEK293T cell lines overexpressing 10 different HERV Env proteins will be generated and used to quantify the abundance of Env-specific antibodies in serum from thousands of cancer, autoimmunity, and infection patients. With this work, we will determine if antibody responses to Env proteins are disease-specific and evaluate the impact of sex, age, and ethnicity on Env antibody titres. Following this, we will build a pangenome reference of HERV sequences in the human population to evaluate the polymorphism of HERV insertions. This database of HERV insertions will be used in combination with highly targeted sequencing (Amplicon-seq) and epigenomics to precisely identify the HERV insertions that are active in pathologies and produce Env proteins. Finally, we will analyse publicly available datasets to evaluate the impact of HERV Env expression on disease progression and survival. In addition to deepening our understanding of several human pathologies, this work could have important impacts on the diagnosis and treatment of complex human diseases.t

Mots clés : human endogenous retroviruses, humoral immunity, autoimmunity, cancer, infection

Participants :
- Institut Francis Crick (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 260347.92 €
Projet STDP-development-AD (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Brain plasticity and neuronal network oscillations are crucial brain processes that depend on the timing precision of neuronal activity. These processes change during healthy brain development and are disrupted early on Alzheimer’s disease (AD) with controversies on the onset of their impairment. Thus, comprehensive studies of plasticity considering the state of the neuronal network during development and AD progression are missing. Here we will address the mechanisms underlying timing-dependent plasticity by the convergent study of spike timing-dependent plasticity and neuronal networks rhythms in mice hippocampal slices. The work plan includes logical sequential sets of experiments involving ex-vivo electrophysiology combined with multiphoton imaging, optogenetic, calcium dynamics, molecular biology, and immunohistochemistry during healthy development in wild-type mice and the progressive impairment of neuronal circuits dynamic in an AD mice model. The action will be implemented during 2 years in the Laboratory of Cellular Neuroscience and Plasticity (LCNP) lead by Professor Antonio Rodríguez Moreno (supervisor) and hosted by University Pablo de Olavide (UPO) in Seville, Spain. All the premises and infrastructures owned by UPO are at full disposal for both the candidate and the supervisor (Manager of the Infrastructure of Multiphoton Unit). During the action the researcher will acquire intellectual skills and learn sophisticated and cutting-edge approaches to assess synaptic plasticity supported by his previous skills and the strong supervisor's background. The expected outcomes from the insertion in a suitable scientific and academic environment at LCNP and UPO will lead the candidate to establish as a young PI within the Spanish Science System. LCNP and UPO will establish the study of neuronal dynamics in a highly convergent way and nurture from the candidate's expertise acquired in both the KI and during the fellowship.

Mots clés : spike timing dependent plasticity, plasticity windows, developing hippocampus, neuronal networks dynamic, theta oscillations, gamma oscillations, alzheimer s disease, early diagnostic tools

Participants :
- Université Pablo de Olavide (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193402.26 €
Projet RuBusT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In order to continue its existence, a society needs people. But how can a society bounce back after it has passed that invisible threshold enabling its own self-reproduction? The RuBusT project tackles this question from an innovative angle, investigating the potential of business transfers (BTs) as catalysts for rural revitalisation. Decades of outmigration and severe ageing have disrupted the spontaneous intergenerational transmission of the rural heritage. As entrepreneurial acts that can jointly preserve social and economic vitality — safer and more productive than startups — BTs appear as a promising avenue to reconnect rural generations and ensure the passage of knowledge from ageing entrepreneurs to younger innovators. Yet, not only are BTs overlooked in rural development strategies, the still developing field of BTs has mostly ignored rural realities, affected by methodologies unable to account for contextual sensitivities, that promote one-size-fits-all policies and that underestimate the level of socialisation of private risks, such as business closures, in vulnerable societies. The project leverages the power of place-based development studies and participatory research to question on the ground each of these assumptions and influence the way we think about and practice BTs in remote rural areas (RRAs). Focusing on rapidly ageing and depopulating communities in Alta Marmilla in Sardinia, Italy, and using challenge-based interactive workshops, the project explores the nature and health of rural BT ecosystems and actively engages with BT stakeholders and citizens to co-design a BT Strategy. In this way, the project aims at strengthening BTs service provision and introducing new business models in BT transactions that prioritise local needs. Its learning outcomes can thus inspire similarly struggling European RRAs with new, practical ways to mitigate the worst effects of unfolding demographic changes and build robust rural societies.

Mots clés : business transfers entrepreneurial ecosystems rural remote rural areas revitalisation intergenerational exchange demographic changes participatory approach place based development sardinia

Participants :
- Université de Cagliari (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €