Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet PORTAL (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This proposal is a “PORTAL” to re-incorporate Dr. Lourdes Farre from the Oswaldo Cruz Foundation (FIOCRUZ) in Brazil to Europe at the Catalan Institute of Oncology (ICO), a part of the Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. She will be supervised by Dr. Alberto Villanueva, leader of the Resistance, Chemotherapy and Orthotopic Xenograft Models Group and Director Board of the EuroPDX (www.europdx.eu) in collaboration with Dr. Ana Sureda, Head of the Hematology Department (ICO). Dr. Farre worked at FIOCRUZ for 12 years where she relevantly contributed in lymphoma research and acquired maturity as an independent researcher. Dr. Farre will contribute to ICO/IDIBELL initiating a new research line in resistance in hematological cancers and transfer her knowledge in HTLV-1 infection. She will also contribute to the ICO Hematology Service with a personalized oncology strategy for clinical oncology practice. Knowledge and preclinical models could be transfer to the IDIBELL`s spin-off Xenopat and Pharmaceuticals. She will have access to a solid multidisciplinary training program that will provide qualitative improvement on her career and a privileged position to be reintegrated in a long term research position in Europe. She has always combined scientific activity with educational interventions. Besides scientific dissemination, she programmed public engagement activities. This proposal is a proof-of-concept of personalized oncology for refractory/relapsed lymphoma and aims to study the mechanisms involved in response to therapy using preclinical humanized orthotopic models. Relapsed/refractory lymphomas represent a major treatment challenge and general treatment paradigm has remained empiric. Defining the best therapeutic option for each patient and overcoming such resistance is a priority. Humanized and orthotopic approach is original and innovative. PORTAL reflects the policy priorities of the Europe 2020 strategy and considers gender issues.

Mots clés : lymphoma, refractoriness, personalised oncology, molecular mechanisms, orthotopic, implantation, preclinical models, htlv 1 associated diseases, bioinformatics, extracellular, vesicles, humanized models

Participants :
- Institut d'Investigació Biomédica de Bellvitge (Espagne) — Coordinator, beneficiary, Recherche, subvention : 170121.6 €
Projet channelopathies (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This proposal is aiming at understanding the structural basis of the type 1 ryanodine receptor (RyR1) regulation by post-translational modifications and by small molecules. RyR1 is present on the sarcoplasmic and endoplasmic reticuli of many mammalian cell types, most notably, in skeletal muscles. RyR channels are required for calcium release from intracellular stores, a process essential for excitation-contraction (EC) coupling in skeletal (RyR1) and cardiac (RyR2) muscles. They are amongst the largest ion channels, comprised of the four identical ~565 kDa channel-forming protomers. RyRs channel activity is regulated by post-translational modifications through multiple signaling pathways including adrenergic stimulation. We have obtained a 4.3 Å resolution cryo-electron microscopy (Cryo-EM) structure of RyR1 in the closed state and a 3.6 Å structure in an activated state. An atomic model was built, defining the transmembrane pore, placing all cytosolic domains as tertiary folds and unambiguously identifying small ligands including calcium, ATP, caffeine and the ryanodine in unprecedented details. In both data sets obtained, 3-D classification of particles revealed multiple distinct conformations providing a broad detailed picture of the dynamic process of RyR1 gating. Here, I aim at improving and completing the atomic model of RyR1 and at determining the structural basis for RyR1 regulation by post-translational modifications and by small molecules. I will use X-ray crystallography to determine the high-resolution structure of the full length RyR1 as well as small fragments including the transmembrane pore and drug binding sites. Cryo–EM and 3-D classification will be used to identify structural changes induced by post-translational modifications and by native ligands and drugs binding. The mechanism of drugs targeting RyRs such as dantrolene and rycals can lead to structure-based design of more potent/safer drugs for malignant hyperthermia and muscular dystrophy.

Mots clés : ryanodine receptor, calcium release channels, ion channels, protein structure, cryo electron microscopy, excitation contraction coupling, post translational modifications

Participants :
- Ben-Gurion University of the Negev (Israël) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 182509.2 €
Projet MoCRIV (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

This proposal presents an interdisciplinary, forward looking, training-by-research plan in the field of physical reliability modeling of emerging transistors and materials beyond 2020. Its main goal is development and validation of a simulation framework which self-consistently considers the main reliability phenomena including bias temperature instability, hot-carrier degradation, and self-heating. These effects were suggested to be the response of interface and oxide defects/precursors which can be activated by different driving forces determined by device operating conditions and specifics of the device topology. Thus, the core of this project will be put on a detailed microscopic description of the properties of defects/precursors, which will be studied experimentally and theoretically. Within this defect-centric paradigm we will address reliability issues in devices with emerging architectures, i.e. fin and nanowire transistors, high-k gate dielectrics, and high mobility channel materials such as SiGe, Ge, and III-V alloys. The unifying model building on the microscopic defect properties will be validated over a wide range of device bias conditions. We will capture the parasitic effect of self-heating which has a strong impact on the energetic distribution of hot carriers and hence on hot-carrier degradation. Special attention will be paid to time-dependent variability of device characteristics which is a response of nanoscale devices on activation/deactivation of individual defects. Knowledge acquired within this project will be valuable for applied and fundamental physics, material science, computational chemistry, electrical engineering, VLSI technology, and circuit design. The research and training activities will enhance applicant’s future career by broadening his professional skills and expertise, expose him to industrial requirements, and open new perspectives for future collaboration with industry.

Mots clés : microelectronics, nanoelectronics, reliability, defects, simulations and modeling, hot carrier degradation, bias temperature instability, self heating, high k dielectrics, high mobility materials

Participants :
- IMEC (Belgique) — Coordinator, beneficiary, Recherche, subvention : 172800.0 €
Projet BRANECOSMOLOGY (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

This proposal promotes a research program in theoretical cosmology to be carried out by M. Schillo at the Institute of Theoretical Physics at K.U. Leuven. The aim of the research will be to address two of the pressing issues in modern cosmology: the lack of a reliable framework in which we can describe accelerating, vacuum dominated universes (such as our own), and the necessity for a theory of quantum gravity to describe the early universe. These problems have recently been impressed upon the cosmological community by the findings of the Planck satellite and the BICEP2 experiment, which provides ample motivation for the integration of high-energy physics and cosmology. Additionally, the fresh outlooks and theoretical models that this program is designed to produce will be necessary for the interpretation of findings of the next generation of ESA missions; without meaningful theories for the data to either support or falsify, the full potential of these missions cannot be realized. The innovative approach which will allow this research to contribute to the state-of-the-art in cosmology and move towards solutions to these problems is the combination of newly discovered dynamics and processes in string theory, which M. Schillo developed in her previous research, with the technologies of quantum cosmology and advanced string theory compactifications, in which the faculty of the high-energy group at K.U. Leuven are world-experts.

Mots clés : quantum cosmology, string cosmology

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172800.0 €
Projet ISSP (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This proposal relates to the sustainability of grassroots, collaborative and participative socio-technical communities to the extent that it focuses on the paradigmatic case of playbour: a concept describing “a condition where play is work and work is play“ and referring to those collaborative and participative assemblages where the dimensions of fun and enjoyment, typical of engagement in play, blur and mix with the ones of productivity and professionalization of participation. Overarching goal of this proposal is to develop a set of guidelines and principles which would support practitioners and scholars in nurturing collaborative infrastructures that embed sustainability by (co)design. The research relies on the analytical lens of infrastructure and infrastructural inversion typical of Science and Technology Studies (STS). At the empirical level the research involves a comparative case study approach which will examine socio-technical collectives which are engaged in playbour and are in the maturity stage of their life cycle. Qualitative data gathering (participant observation and interviewing) and inductive analysis techniques (grounded theory) will be adopted for this study. The impact of this study will be relevant to the extent that European Commission is also trying to nurture and steer collaborative, grassroots and innovative initiatives (e.g. "Open and Participative Innovation" and "Collective Awareness Platform for Sustainability and Social Innovation” frames). The result of this research will also provide practical insights for the sustainability of these instances.

Mots clés : playbour, infrastructural inversion, sustainability, design guidelines and principles, socio technical collectives, cyberethnography, action research

Participants :
- IT University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200194.8 €
Projet PromoTeRapy (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

This proposal will develop a new tool to rescue haploinsufficiency, which underlies many genetic disorders of neuronal excitability, and provide a new approach to treatment of intractable epilepsy. This new tool is based on the CRISPR-On technology which can regulate the expression of endogenous genes by directly targeting their promoters, which allows expression of the full panoply of splice variants and untranslated regulatory sequences. Importantly, the method does not require integrating exogenous genes into the genome, which has potential risks of insertional mutagenesis. Haploinsufficency of SCN1A, which encodes the sodium channel Nav1.1, leads to Dravet Syndrome, a severe epilepsy. My first aim is to increase SCN1A gene expression in interneurons derived by reprogramming fibroblasts obtained from Dravet Syndrome patients. I will then determine whether this strategy can be effective in non-genetic epilepsies by applying CRISPR-On technology to increase KNCA1(Kv1.1) expression in excitatory neurons in a mouse model of focal epilepsy. This project will combine my previous experience with functional analysis of neurons in different epileptic models; an unparalleled resource of genetically-characterized patients, a well characterized model of intractable epilepsy, and gene therapy techniques at the UCL Institute of Neurology; and expertise on the CRISPR-On method and fibroblast reprogramming of international collaborators. Epilepsy is one of the most important health burdens within the clinical neurosciences, and finding tools that open new mechanistic and therapeutic insights is a high priority. My proposal exploits an opportunity to establish a new tool to treat epileptic disorders and to create an international multidisciplinary network including neurophysiology, clinical neurology, molecular biology, biophysics and genetics.

Mots clés : epilepsy, gene therapy, ion channels, cell reprogramming, electrophysiology

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet MOVEMED (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

This proposal will investigate the dynamics and links between human mobility and marine megafauna movement using a computationally intensive data-driven approach. I will analyse the effects of marine environment and cumulative human pressures on marine megafauna using electronic monitoring systems and earth observations, which now allow an unprecedented opportunity to simultaneously monitor marine animal movement, ship-based activities and the marine environment. I will direct the research through a multidisciplinary approach, combining state-of-the-art quantitative methods and computational tools from movement ecology, oceanography and marine spatial planning. I will demonstrate this approach in the Mediterranean Sea, a hotspot for marine megafauna under pressure from multiple human influences. The region can serve as a miniature ocean to investigate climate-driven effects and explore the potential application of dynamic conservation measures in trans-boundary areas. Results will allow the linking of key enabling ocean observation technologies to their application in assessing the potential impacts from anthropogenic activities and promoting the sustainable development of maritime industries. This is a matter of enormous concern for Europe, since our results will provide the scientific basis to establish future conservation actions within the framework of Integrated Maritime Policy. This proposal marries skills and expertise that maximizes the chances of the project’s success. The host lab, supervised by Prof Godley, has a long history of research in marine movement ecology, particularly those associated with marine vertebrates and conservation research. The candidate, Dr March, is an expert in marine spatial ecology and ocean observing systems. The combined skill-set will allow the team to address fundamental, timely and important questions about animal ecology and conservation.

Mots clés : marine megafauna, movement ecology, marine spatial planning, cumulative impact mapping, ocean observing systems, mediterranean sea, big data, species distribution modelling

Participants :
- University of Exeter (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet HRMN (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This research deals with the rise of memorialization standards and policy-oriented attempts to engage transitional societies to develop and adopt specific normative forms of remembrance. This project addresses one particular human rights assumption - that the standardization of memory enforced through memorialization policies is effective and necessary in promoting human rights values. Human rights advocates insist on memorialization as a crucial step in establishing moral responsibility for past atrocities understanding it as an insurance policy against the repetition of crimes. In nationalist ideologies, however, memory and memorialization is used for the sake of defining the “self” and the “other” through boundaries along ethnic lines. The project investigates the ways in which human rights advocates understand, promote and mandate supposedly universal memorialization standards, asking whether in so doing they weaken or instead often actually strengthen nationalism. Within the University College Dublin, School of Sociology, and under supervision of Prof Malešević, a world-known expert in nationalism, the goal of this project is to get 1) new theoretical framework for the critical interdisciplinary study of human rights` memorialization policy; 2) new empirical insights into whether in different national contexts (in the Balkans and the Middle East) the prescribed standards of memory are being promoted, and if so, by whom and to what ends; 3) to develop case and gender-sensitive and cost-effective policy recommendations for future implementation of the EU human rights` memorialization policies. Successful realization of the project will enable Dr David to get a tenure track position at Hebrew University, where she will further use the acquired knowledge to search for innovative solutions to strengthen human rights.

Mots clés : memorialization policy, standardization of memory, human rights, nationalism, the balkans, the middle east

Participants :
- National University of Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187866.0 €
Projet TUECS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This research examines Europol's fight against cybercrime in the context of Uberization. It investigates Europol's Uber-like intermediary role within an online platform where it matches idle forensic investigation capacity of private actors with national law enforcement agencies who are seeking technical guidance and collaboration in cybercrime. It aims to reveal the interaction dynamics between Europol, national law enforcement agencies and private actors who have diverging interests in a sensitive crime area where investigations are made with secrecy and discretion. The research qualitatively investigates (official documents, review of current literature and semi-structured interviews with stakeholders) Uberization in three major cybercrime areas namely; ransomware, money laundering in cryptocurrencies and online child sexual abuse that Europol has already pushed private and public actors to collaborate. The central argument of this project is that an Uber-like online platform governed by Europol offers an entrepreneurial opportunity for private cybersecurity actors to connect with law enforcement agencies who need skilled-experts to investigate cybercrime cases. This innovative governance model gathers all stakeholders under the same platform, aggregates their qualifications using different algorithms, reduces their cooperation costs, regulates and motivates their interaction. This research aims to contribute to the existing scientific knowledge by the development of Uberization theory. It also provides an alternative governance model to enhance public and private partnership not only in cybercrime area but also in other policy areas where an innovative solution is needed to fill the expert deficit.

Mots clés : uberization, europol, cybercrime, public private partnership, outsourcing, talent gap, shared economy model, ransomware, money laundering with cryptocurrencies, online child sexual abuse

Participants :
- University of South Wales (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet WoRD-DoME (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This research focuses on tensions between discourses of multiculturalism and women’s economic rights and the processes in which they arise in development institutions and programs. While the multidisciplinary literature on development unpacks public declarations by development institutions and studies the local implementation of development programs, it evades two crucial questions: conditions of agency formation and inequality in institutional processes, and the role assumptions about cultural difference play in development paradigms. This research fills these gaps by exploring how issues of women’s economic rights and notions of cultural difference are negotiated inside development institutions and reflected in their programs. The research deploys two data collection strategies, longitudinal content and discourse analysis of relevant development reports and interviews with gender experts with work experience on the Middle East. It will be conducted at the Gender Centre of the Graduate Institute of International and Development Studies, under the supervision of Professor Elisabeth Prügl, a best fit for the project given the rich array of gender and development scholarship at the Centre, its established networks with the multilateral actors in Geneva and beyond, and the two scholars’ mutual interests in the area of gender expertise and gender equality. It is an interdisciplinary project, informed by relevant studies in the fields of anthropology, sociology and political science, and has significant potential to contribute development studies and feminist political economy. It builds on the researcher’s experience in the field of gender and development, the Middle East and transnational networks. It expands her research to international gender experts in development; grows her expertise on the Middle East; and enlarges her fieldwork scope to Europe. The training, networking and publication prospects put her on a firm path toward professorship.

Mots clés : women s rights, cultural difference, development, international institutions of governance, gender experts

Participants :
- Graduate Institute of International and Development Studies (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 117137.25 €