Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CoMAnD (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : TERMINATED

Diffuse large B-cell lymphoma (DLBCL) accounts for over one-third of lymphomas and is fatal in up to 40% of cases. Particularly poor survival is associated with DLBCL subtypes that over-express the oncogene MYC and contain the cancer-causing Epstein-Barr virus (EBV). These tumours frequently resist apoptosis, with a poorer response to chemotherapy. Recent evidence has strongly implicated a role for the tumour microenvironment (TME) in cancer progression; however, the relationship between EBV, MYC, and the TME in DLBCL remains poorly understood. CoMAnD aims to elucidate the synergistic relationship between EBV, MYC and the TME to explore how these oncogenic drivers converge to protect DLBCL tumours from apoptosis. This will be achieved using a new generation of EBV+ and EBV- DLBCL models to derive novel insights into the biology of EBV+ DLBCL. This will be coupled with state-of-the-art intravital imaging of tumour progression in humanised mice and highly multiplexed, spatially resolved, imaging of the TME in EBV+/- patient tumours. This will allow the study, in unprecedented detail, of the impact of viral and cellular oncogenic drivers on the TME and apoptosis in DLBCL. This research directly contributes to Cancer- and Infectious disease-related EU and UN goals, and will support the areas of Open Science, Gender Equality, and the Green Charter. The Fellow will spend 2 years at the Walter and Elisa Hall Institute of Medical Research (Australia) expanding her skills in in vitro disease mimetics, and acquiring a skillset in apoptotic pathways and intravital imaging. She will return to the University of Limerick (Ireland) and receive training in high-dimensional imaging and data analytics. The Fellow will be immersed within a multidisciplinary team with expertise in lymphomagenesis, virology, apoptosis and the TME; they will support her in meeting the research/training objectives and preparing for an independent career in the field of EBV-associated lymphomagenesis.

Mots clés : epstein barr virus lymphoma

Participants :
- Université de Limerick (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276864.48 €
- The walter and eliza hall institute of medical research public companylimited by guarantee (Australie) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet NOMECH (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The NOMECH project examines fiction by Indigenous American authors of the late twentieth century for literary representations of animals, automobiles, and the natural environment. NOMECH develops a novel approach to reading the road journey in American fiction (a genre which has historically excluded Indigenous writers) by centring Indigenous stories in which the environment is frequently presented as a character in and of itself, in contrast to the colonial tendency to personify the cars and ignore the living nonhuman world under the wheels. Combining approaches from literary studies and the environmental humanities, NOMECH explores the extent to which Indigenous American authors present counter-narratives to the colonial story of automobility in which human contact with the natural environment is defined by driving over it: moving from a relationship based on dominance, conquest, and subjugation to one which places more emphasis on mutually beneficial ways of living with other animals and technology. Exploring fiction from 1960–2000 by authors such as Leslie Marmon Silko (Laguna Pueblo), David Seals (Huron), Sherman Alexie (Spokane-Coeur d’Alene), while endeavouring to uncover lesser-known Indigenous texts in the collections of KWEC—the Kim Wait/Eisenberg Native American Literature Collection (Amherst, MA), NOMECH seeks to answer the following research questions: To what extent is humanity’s relationship to the automobile reimagined in Indigenous American fiction? How did Indigenous authors challenge the stereotype of technological ineptitude without compromising on traditional relationships to the environment? And how does the symbolic reverence for Indigenous ways of life in automotive culture obscure the very real violence against such populations? The outcomes of the project include, among others, a public-facing exhibition (online and in-person) at KWEC.

Mots clés : environmental humanities indigenous literature american literature twentieth century automobile animal studies

Participants :
- Université de Stavanger (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226751.04 €
Projet MuSICA-V (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Venus is the closest planet to Earth. Despite a similar size and mass, there are differences between the two planets. At the surface, the temperature can reach 730 K with a pressure of 90 bar, and a composition of 96 % of carbon dioxide. Venus hosts a global cloud layer between 45 and 70 km of altitude, with composition and temperature-pressure conditions close to the Earth's stratosphere and complex chemistry with both sulphur and water cycle. This global cloud layer plays a key role in the radiative equilibrium of the atmosphere. Therefore, it is fundamental to study its composition and dynamics at all spatio-temporal scales to understand the atmosphere of Venus. Despite decades of measurements and modelling, there are still many unknowns about the chemistry of the Venusian atmosphere. The Project MuSICA-V (Multi-Scale Investigation of the Chemistry of the Atmosphere of Venus) conducted at LATMOS will develop new and ambitious numerical models using a hierarchy of models: a Planetary Climate Model (PCM), mesoscale and Large-Eddy Simulation (LES) models all coupled to a photochemistry scheme. These three models are performed with different resolutions and would help capture the spatio-temporal variability of the chemistry over different scales as never before, and will increase the understanding of the coupling of the dynamics and chemistry from the large-scale to the small-scales. The proposed effort is perfectly timed and relevant to ongoing and planned international Venus exploration activities: ESA mission EnVision, and NASA missions DAVINCI and VERITAS, were all three selected to launch in the next decade. The main objectives of these missions are to study the surface and the dynamics both inside and below the clouds. The project will simulate predictions for chemistry variabilities to produce observables for past and future missions, to improve the interpretation of the measurements.

Mots clés : planetary science atmospheric chemistry turbulent mixing remote spectroscopy venus

Participants :
- Sorbonne Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
- L'Institut royal d'Aéronomie Spatiale de Belgique (Belgique) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet CORES (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

CO2 is a potent greenhouse gas and the primary cause of global climate change (GCC). Among others, GCC induces extreme weather events, producing an extensive impact on natural and agricultural systems. Climate change mitigation requires an urgent decrease in CO2 emissions together with active CO2 removal from the atmosphere. Enhanced silicate weathering (ESW) is a promising negative emission technology for CO2 removal but requires further research. ESW accelerates the natural process of weathering-based silicate to carbonate transformation, by increasing the surface area of silicate rocks. During the weathering process, CO2 is sequestered. Agricultural fields are ideal for ESW, due to ease of access, equipment availability and infrastructural capacity. In an agricultural setting, this application can be further beneficial as the silicate rocks like basalt contains elements that promote plant growth and soil health. In addition, GCC endangers crop production by inducing drought and salinity. Approximately 75% of the cropland is subjected to drought-related yield loss while salinity affects around 50-80% of global croplands. Moreover, impacts of drought and salinity are anticipated to rise in the future due to GCC. The negative effects of drought and salinity can be countered by ESW through (i) the preservation of crop yield and quality by the silicon (Si) mediated drought and salt stress tolerance in plants and (ii) the protection of soil microbiota by the stabilization of soil chemistry. Although ESW could contribute to climate change adaptation in agriculture, these promising co-benefits were never assessed, and further research is needed to evaluate this potential in different agricultural settings. In project CORES, I aim to examine the potential of ESW, with silicate mineral basalt, for the protection of yield and quality of major crop maize and associated soil microbiota under drought and saline conditions and establish the groundwork for future field trials.

Mots clés : carbon sequestration, negative emission technology, climate change adaptation, plant and soil protection under stress conditions, enhanced silicate weathering

Participants :
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
Projet DAHAD (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Nowadays, available surgical skin closure techniques still remain painful and are prone to infections. To assess these challenges, DAHAD aims to develop new hydrogels with a dual action: biological tissues adhesion and antibacterial activity. The hydrogels will be prepared by the gelation of biomimetic dendrimer-polymer hybrids in aqueous solutions. These hybrids will be composed of a central linear polymer, namely Pluronic® F-127, decorated at its extremities with multiple biomimetic catechol moieties to confer biological adhesive properties to the gels. The hydrogels will be loaded with diverse hydrophilic and lipophilic antibiotics to locally deliver them into the surgical site and prevent infections. DAHAD contemplates (i) the organic synthesis of the dendrimer-polymer hybrids, (ii) the hydrogels preparation and the study of their adhesiveness, physicochemical characterization and thermo-responsiveness (iii) the drug delivery of hydrophilic and lipophilic antibiotics throughout the hydrogels by direct diffusion or assisted by micellar nanoparticles and their skin biocompatibility (iv) and the back loop enhancement of the gelation abilities, adhesion and drug delivery results using hydrogen bonding (H-bonding) supramolecular chemistry.  DAHAD is built as a multidisciplinary and international project along which the Purdue University (USA), the Universidad de Zaragoza (Spain) and the Instituto de Nanociencia y Materiales de Aragón (Spain) will combine their efforts and expertise to pursue the planned R&I objectives, as well as the dissemination of the results to scientific, industrial and public audiences. It aims to boost the applicant’s career, to complement the expertise of INMA in biomaterials for medical applications and be the kick-starter of a solid, international and successful collaborative network.

Mots clés : hydrogels, adhesives, antibacterial, biomimetic, dendrimer polymer hybrids, drug delivery, supramolecular chemistry

Participants :
- Université Purdue (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 186912.24 €
Projet RADIANT-HOPE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Hepatocellular carcinoma (HCC) ranks the sixth most common cancer and third leading cause of cancer-related death worldwide. Most patients are diagnosed at an advanced stage. For advanced HCC immunotherapy has been approved as the standard-of-care first-line treatment. However, only about one third of patients respond to immunotherapy. How to predict immunotherapy efficacy and early identify HCC patients who are likely to benefit from it is an urgent clinical problem. RADIANT-HOPE aims to address this problem by developing and externally validating a radiomics model based on clinical routine computed tomography (CT) images. To achieve this, a novel comprehensive framework will be proposed to automatically segment the tumor, expand the tumor margin, and extract radiomics features from intra- and peritumor regions at pretreatment triphasic CT images. These features will be unsupervised clustered into clinically meaningful sub-phenotypes, and patients are stratified into different risk groups of immunotherapy response. Multi-omic data (e.g. mRNA) will be profiled and compared between the sub-phenotypes. Radiogenomic analysis will be performed to evaluate their genomic foundation. The model will be validated in independent international cohorts and developed as software for facilitating clinical utility. This project adopts highly interdisciplinary and intersectoral approaches, integrating oncology, immunology, radiology, artificial intelligence, and bioinformatics. The proposed radiomics model has the potential to provide a non-invasive, accurate, wide accessible imaging biomarker for predicting immunotherapy efficacy and patient stratification. The model implementation in clinic will contribute to HCC personalized treatment, optimize healthcare resources allocation and significantly reduce healthcare costs. As a hepatobiliary surgeon and clinic-oriented researcher, my extensive experience in HCC and radiomics & AI makes me an ideal candidate to conduct this project.

Mots clés : hepatocellular carcinoma immunotherapy radiomics machine learning artificial intelligence imaging biomarker

Participants :
- Fundació Clínic per a la Recerca Biomèdica (Espagne) — Coordinator, beneficiary, Recherche, subvention : 209914.56 €
Projet IMCSC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Optical frequency combs (OFC) play an essential role in precision, timing and navigation applications. Integrated photonics facilities the development of OFC-based applications towards chip-scale miniature package. Most applications require detecting the radio frequency (RF) signals of a OFC (i.e. repetition rate and carrier-envelope offset frequency). Thus, an important step towards miniaturized complex OFC systems is to integrate the OFC generation with the auxiliaries components required for detecting its RF signals onto the same chip. This project aim to develop an integrated microcomb system chip with accessible RF signals detection using heterogeneously integrated photonic platforms. Silicon nitride (SiN) platforms have shown their superiority in comb generations using microresonators (i.e. microcomb), with octave-spanning spectrum and dispersive wave emissions that enable detection of the carrier-envelope offset frequency via f-2f self-referencing process. Thin-film lithium niobate (TFLN) platforms are advantageous in second-order nonlinear frequency conversions and electro-optics modulations, the former can be applied for the f-2f process, while the latter is widely used for frequency down-converting the high-frequency repetition rate of a microcomb. Therefore, this project will explore heterogeneous integration technique to combine the SiN microcomb generator with TFLN devices for f-2f process and frequency down-conversion on a single chip. Specially, a novel photonic molecule structure will be explored for power-efficient octave-spanning microcomb generation with strong dispersive wave emission. A broadband electro-optics frequency comb will be developed for frequency down-conversion of microcomb repetition rate. Periodically poling of TFLN waveguide will be explored for frequency doubling in f-2f process. Heterogeneous integration will bring together all these components to deliver an integrated microcomb system.

Mots clés : optical frequency comb, integrated photonics, heterogeneous integration

Participants :
- École polytechnique Chalmers (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 236340.0 €
Projet NANORIBS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Ribosomes, once considered uniform molecular entities, are now recognized for their compositional heterogeneity, challenging traditional views on their role in gene expression. This has led to the hypothesis of 'specialised' ribosomes that selectively translate specific mRNA subsets, though the extent of this specialisation, particularly in cell fate determination, remains debated. Recent findings suggest that rRNA modifications, such as 2’-O methylation, may drive ribosomal specialisation during cellular differentiation. However, how these modifications translate into specialised functions is still poorly understood. Current methods like ribosome profiling (RiboSeq) offer limited resolution, particularly at the isoform level and in untranslated regions (UTRs), limiting our ability to fully elucidate ribosome specialisation.  To address this, I propose NANORIBS, a novel nanopore-based ribosome profiling technique that achieves single-molecule resolution of ribosome footprints on full-length mRNAs. This method leverages long-read sequencing to preserve critical information such as poly-A tail length and UTR sequences, essential for understanding ribosome-mRNA interactions. NANORIBS will investigate the role of specific rRNA methylations, particularly the 18S:355Um modification, in neuronal cell fate commitment.  By offering unprecedented insights into the molecular mechanisms governing ribosome-mediated translation regulation during differentiation, NANORIBS could revolutionise our understanding of gene expression control at the translational level. Deciphering the functional consequences of rRNA modifications could lead to new therapeutic targets and strategies for diseases linked to aberrant cell differentiation, such as cancer and neurodegenerative disorders. NANORIBS not only advances ribosome biology but also paves the way for future research into the broader implications of ribosomal specialisation in health and disease.

Mots clés : epitranscriptomics specialised ribosomes translational control and regulation method development

Participants :
- Centro de Regulación Genómica (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €
Projet ProBat (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Large-scale battery system applications, e.g., transportation electrification and grid-level renewable energy integration, are vital for the EU to achieve net-zero emissions by 2050. In such battery systems, real-time operating behaviours of individual battery cells determine the system’s overall performance and safety, highlighting the need to develop cell behaviour-aware control algorithms for advanced battery system management. Thus, in this proposal, we will take into account the specific operating limits of all internal battery cells for accurately predicting and significantly boosting battery system's maximum allowable charge and discharge power, i.e., state of power (SoP). Then, the obtained cell behaviour-aware battery system SoPs will act as the operating power limits for further optimising the system's operation performance. As an MSCA-PF fellow, Dr. Weiji Han will receive crucial training at the Chalmers University of Technology and engage in detailed battery system modelling and control works which span the areas of circuit analysis, automatic control, and optimisation. The interplay between these areas will spark an innovative and productive throughput, including 1) an accurate prediction algorithm for the long-horizon SoPs of battery systems, 2) a high-efficiency dynamic reconfiguration algorithm for boosting battery system SoPs, and 3) an optimal control framework of dynamic reconfiguration for optimising battery system performance based on adapted deep reinforcement learning (DRL). The major novelties or contributions will include: considering both battery parameter update and operating constraints during the prediction horizon to enhance the prediction accuracy of long-horizon SoPs; unifying the modelling of reconfigurable battery systems to significantly reduce the modelling efforts and facilitate the formulation of control or optimisation problems; narrowing the search space and adapting the DRL method to achieve higher computational efficiency.

Mots clés : battery management systems, power capability, state of power, battery reconfiguration, deep reinforcement learning

Participants :
- École polytechnique Chalmers (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252180.0 €
Projet ONE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

All animals have specialized cells that can generate small electric currents, such as neurons or muscle cells. However, the ability to generate external electric fields is restricted to only few teleost and elasmobranch species. This function evolved independently at least six times, generating different specialized electric organs composed of cells called electrocytes that generate these electric fields. In most species, electrocytes have convergently evolved from muscle cells. Nonetheless, in Apteronoidae, a small tropical clade that shares a common ancestor with other fish with a myogenic electric organ, electrocytes have evolved de novo from spinal cord motor neuron precursors. These neurogenic electrocytes create the electric organ by packing axons with unique morphological properties: no pre-synaptic terminal, U-shape with a 5-fold changing diameter and unique myelination pattern. However, nothing is known about the molecular changes that underlie these striking evolutionary novelties, to a large extent due to the difficulty to access the somas of electrocytes, which are intermingled within other spinal cord cells. The goal of ONE is to elucidate the genomic and regulatory bases of the origin of the neurogenic electrocytes in Apteronoidae. This will be possible thanks to the use of cutting-edge single-cell multi-omics technologies, which will allow us to investigate this cell type at the transcriptomic and regulatory levels for the first time (Aim 1). I will then use comparative approaches with close fish relatives and between neurogenic and myogenic electrocytes to identify unique and convergent evolutionary genomic patterns (Aim 2). Altogether, ONE will positively impact neuroscience and evolutionary research, revealing new mechanisms of novel cell-type evolution. Moreover, we will discover new genetic variants that might be applied to biotechnology and biomedicine and that will further help to raise awareness of the importance of conserving Biodiversity.

Mots clés : whole genome sequencing, transcriptomics, non coding dna, chromatin accessibility, single cell sequencing, multiomics, nervous system, cell excitability, non model organism

Participants :
- Centro de Regulación Genómica (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €