Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet TMSHADS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

In the realm of dynamical systems, the study of the Shadowing property has emerged as a pivotal endeavor, offering profound insights into the behavior of chaotic systems. This project delves into the intricacies of the Shadowing property across three distinct frameworks: Shadowable Measures and Points, CW-hyperbolic Homeomorphisms, and Singular Flows, each with their unique characteristics and challenges. With a focus on these disparate contexts, our investigation aims to unravel the implications of shadowing for the chaotic nature of such systems, while also unraveling the obstructions that arise in continuous time cases.  Our exploration into Shadowable Measures and Points harnesses we seeks the existence of invariant shadowable measures and their role in the existence of odometers, shedding light on the fundamental nature of periodicity in chaotic dynamics. In the domain of CW-hyperbolic Homeomorphisms, we navigate the dynamic interplay of hyperbolicity and chaos. Our focus extends to investigating periodic shadowing, periodic specification, measures of maximal entropy, and the discovery of new examples that contribute to the broader landscape of chaotic systems theory. Furthermore, our investigation extends to Singular Flows, where we confront the nuanced challenges presented by singularities in continuous time dynamics. We investigate when the existence of attached singularities forbids a flow to satisfy the shadowing property. This exploration not only advances our understanding of continuous-time systems but also evidences a remarkable difference between the discrete-time and continuous-time contexts.

Mots clés : dynamical system, shadowing property, entropy, invariant measure, attractor

Participants :
- École des mines et de la métallurgie de Cracovie (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 155793.6 €
Projet MOD-REG (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Regulatory T cells (Tregs) are important for maintaining tolerance to self and are known to contribute to appropriate priming in the case of foreign challenges, however, their role in liver homeostasis and disease remains to be determined. Liver disease represents a significant global health issue with Hepatitis B Virus (HBV), Metabolic dysfunction-associated Steatotic Liver Disease (MASLD), and Hepatocellular Carcinoma (HCC) resulting in considerable morbidity and mortality worldwide and limited treatments are available to address these conditions. This project aims to identify novel mechanisms of targeting Tregs in liver disease to suggest methods to manipulate these cells for therapeutic benefit. Cutting-edge mouse models of HBV, MASLD, and HCC will be used to determine the phenotypes, kinetics, and localisation of Tregs in the liver under homeostasis and during disease. High parameter flow cytometry, spatial transcriptomics, and state-of-the-art intravital imaging will allow us to investigate high-resolution spatiotemporal dynamics of liver Tregs to identify novel molecules, interactions, and functions of these cells. Tissue samples from human patient HBV and HCC cohorts are available to the host lab and can be used to screen and refine the molecules of interest identified in mouse liver Tregs to focus further investigation on clinically relevant molecules. The role of Tregs in T cell priming in HBV, and effects on MASLD progression, and HCC development will be determined using mouse models to specifically deplete Tregs, or delete molecules of interest in Tregs, at defined disease stages. Overall, this project will significantly advance our understanding of Tregs in the liver and has the potential to reveal promising clinical targets. The training in experimental techniques, research communication, and transfer of knowledge my career will be developed towards my goal of becoming an independent researcher.

Mots clés : tregs, hepatitis b virus, non alcoholic fatty liver disease, hepatocellular carcinoma

Participants :
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 188590.08 €
Projet ENRICHING-HDR (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Hematopoietic stem and progenitor cell (HSPC) gene therapy involving viral vectors has shown remarkable promise in treating severe genetic disorders. The advent of gene editing technologies offers new possibilities for broadening the scope of HSPC gene therapy by enabling precise in situ gene correction or targeted transgene integration through homology-directed repair (HDR). However, HDR efficiency in HSPCs remains limited due to their cell cycle dynamics, suboptimal responses to the repair template, and the dominance of error-prone DNA repair pathways such as non-homologous end joining (NHEJ) and microhomology-mediated end joining (MMEJ), which negatively impact the engraftment of HDR-edited cells in vivo. This proposal aims to overcome these challenges by introducing an innovative "purifying selection" strategy. By using CRISPR/Cas9 to target essential genes that are haplo-insufficient in HSPCs, only cells undergoing HDR-mediated insertion of the gene of interest (GOI) will restore the function of the essential gene, while non-HDR edited cells will fail to recover, leading to their elimination. This selective enrichment of HDR-edited cells will dramatically enhance the precision and efficacy of gene editing. ENRICHING-HDR project will focus on identifying critical genes required for HSPC survival and maintenance through genome-wide CRISPR screening, selecting the most promising candidates for purifying selection, and evaluating the system's precision and platformability for clinical application. This project will establish a standardized platform for guide/nuclease reagents and template delivery, enabling reliable genomic integration and rapid adaptation of new therapeutic transgenes, streamlining the development of targeted therapies. The comprehensive training in advanced experimental techniques, research communication, and knowledge transfer will be instrumental in shaping my career trajectory, driving me toward my goal of becoming an independent researcher.

Mots clés : gene therapy, gene editing, homology directed repair, hematopoietic stem and progenitor cells, genome integrity

Participants :
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 209483.28 €
Projet ARAMIZDA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

After 60 years of migration in countless waves, Germany’s Turkish-speaking communities are complex and diverse. Routinely lumped together by policymakers, media and the public as “Turks”, they in fact encompass a multitude of ethnicities, religions, classes and political groupings. Though they live side-by-side, they often have little contact and frequently harbour disparaging, even hostile feelings towards each other. ARAMIZDA (meaning “between/among us” in Turkish), draws on methods and theories from a range of disciplines to produce novel, high-quality research on divisions within Berlin’s Turkish-speaking communities. It explores the role civil society organisations play in easing and exacerbating those divides. Previous work on Europe’s large Turkish-speaking diasporas (including Kurds) has been mostly concerned with these groups’ links to Turkey or their integration with host populations. No detailed study has focused explicitly on how they interact with each other. At a time when European policymakers are grappling with the paradox of growing spaces for minority communities but shrinking opportunities for social dialogue, the project will use a mix of social science methods (including ethnographic fieldwork, diaries and interviews) to collect rich data to understand divisions within Turkish-speaking communities. It will foster collaboration with research participants by inviting them to play a role in determining data collection methods and taking an active role in a key non-academic offshoot of the project. This final aspect will take the form of workshop, run in partnership with an anti-polarisation charity, aimed at piloting ways of encouraging diverse groups to engage in dialogue. The findings — which will be widely dispersed through academic and non-academic channels — will be used to advance theories on diversity and inclusion, increase understanding among policymakers and the public, and test practical ways to build more united and resilient societies.

Mots clés : turkey, diaspora, social anthropology, polarisation, migration policy

Participants :
- Maecenata foundation (Allemagne) — Coordinator, beneficiary, Autres, subvention : 237109.2 €
- More in common ev (Allemagne) — Partner, associated partner, Autres, subvention : 0.0 €
Projet SPRING-6G (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Sensing-aided positioning is poised to be a key enabler for future sixth-generation (6G) systems, yet innovative approaches are required to realize its full potential. Future networks will integrate sensing-aided positioning to elevate accuracy and reduce latency, extending capabilities beyond traditional data communication. However, many IoT applications demand ultra-low power consumption, a requirement not fully supported by current 5G networks, posing challenges to the development of accurate sensing-aided positioning systems. This project addresses critical challenges preventing the large-scale deployment of reliable positioning services in 5G and beyond, such as computation latency due to path loss, mmWave channel constraints, range accuracy, angular estimation, and computational complexity. To tackle these issues, we propose SPRING-6G (Sensing-Aided Positioning with Reconfigurable Intelligent Surfaces for Next-Generation 6G), which will explore the design and implementation of sensing and positioning algorithms tailored for Reduced Capability (RedCap) systems, leveraging Reconfigurable Intelligent Surfaces (RIS) for enhanced control. We will develop a high-resolution iterative estimation algorithm utilizing the line-of-sight (LoS) path with RIS for uplink 6G terahertz (THz) networks and also machine learning (ML)-based beam management framework that is computationally efficient and converge reachable, which minimizes large training overhead and optimizes sensing accuracy above 95% and latency from 500 to 100 ms or less and 30% system complexity reduction when compared to state-of-the-art sensing-aided positioning methods. The SPRING-6G project is centered around four key objectives: enhancing sensing capabilities, improving accuracy and resolution, reducing processing latency, and managing hardware complexity, paving the way for scalable, efficient, and highly accurate positioning systems in 6G networks.

Mots clés : sixth generation 6g , reduced capability redcap device, ssensing, positioning, angle of arrival aoa estimation, machine learning ml , and wireless communication

Participants :
- U-blox malmö (Suède) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Mid Sweden University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252180.0 €
Projet TRESOR (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Spectroscopy is an important tool to understand molecular and atomic phenomena. Dual comb spectroscopy DCS and asynchronous optical sampling AOSPS are prominent techniques in infrared and Terahertz range respectively. Both rely on dual frequency combs or dual (FC), and their limitations stem from the comb design, necessitating a trade-off between speed and resolution. The spectral resolution is limited by the repetition rate of the FC. The most common sources for FC are mode-locked lasers and electro-optic modulators. However, due to technical peculiarities, these techniques are not suited for low repetition rates, leading most spectroscopy systems in the 100 MHz-10GHz range. TRESOR (Terahertz high resolution spectroscopy using driven optical resonators) aims to showcase a novel optical platform based on ultrashort pulses in low repetition rate, high-Q resonator, to address the limitations inherent in FC based spectroscopy methods. On the fundamental front, I will investigate the generation of novel soliton formations, such as super cavity solitons SCS in high intrinsic loss resonator with large detuning. So far, SCS in low repetition rate resonators have not been experimentally explored, mainly because of the lack of a sufficiently precise perturbation. To use the FC based on SCS in the THz range, pulses need to be amplified. This will give rise to a new challenge related to sub-200fs pulse amplification. On the applied side, by using FC based on SCS, TRESOR can improve the resolution and speed of current spectroscopy methods and give rise to new nonlinear measurement techniques. Despite these fundamental and applied reasons, the experimental approach of TRESOR will overcome such challenges and enable the realization of high-resolution spectroscopy in the THz range with performance beyond the state of art. This project is a step forward in my career because it will act as a springboard towards a permanent research position and will allow me to lead a research group

Mots clés : cavity solitons dual comb spectroscopy kerr resonators

Participants :
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
Projet BECoop (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

To cure diabetes, functional ß cell mass must be restored. Transplantation of human islets has seen significant progress over the past decades. However, organ donor shortage is a major obstacle. For transplanted patients, poor graft revascularisation and a recurrent autoimmune attack ultimately result in the loss of the graft. Human induced pluripotent stem cell (iPSC)-derived ß cells are a promising alternative source of cells that is inexhaustible and allows genetic interventions prior to transplantation to stimulate revascularisation, immunoprotection and ultimately graft survival. iPSC-ß cells retain an immature phenotype in vitro and only in vivo acquire mature function equivalent to that of native human islets. Intra-islet endothelial cells (ECs) form a necessary niche for pancreatic endocrinogenesis and adult ß-cell function, and they improve islet survival after transplantation. This proposal aims to test the hypothesis that ECs are crucial to generate mature and functional human iPSC-derived islet organoids in vitro and to promote revascularisation, function, adaptation to metabolic challenges and survival in vivo. To this end, we will generate 'vascularised' islet organoids containing iPSC-derived endocrine and ECs. By combining genetic interventions and cutting-edge technologies, such as whole tissue three-dimensional analysis and transcriptomics, we will characterise the impact of ECs on islet organoids. This project will broaden the knowledge on the essential relationship linking structure to function in human islet organoids, paving the way for new human cell therapies.

Mots clés : beta cell, endothelial cell, human induced pluripotent stem cell, three dimensional analysis, transcriptomics, adaptation to pregnancy

Participants :
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet PestFinder (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The goal of this project is to contribute to the ongoing “precision agriculture” revolution by developing model-based control strategies for pest control. The project will be carried out with a high interdisciplinary approach between control and system engineers and entomologists. We firstly aim to develop models and methodologies that can guide in an optimal way the agronomical decisions (both in terms of monitoring and of control actions) that impact pest control. To pursue this aim, the first part of the project will be devoted to the development and validation of models able to capture both the spatial diffusion and the temporal evolution of insects in a plantation. These models will be parametrized w.r.t. environmental parameters (temperature and humidity) and control inputs (e.g., pesticides). The focus will be then shift on how to use these models for pest monitoring, and in particular on the interplay between quality of the estimation and data collection, in order to develop optimal data collection policies. In the last part of the project, we will use the developed results to develop model-based optimal pest control policies. Although we aim to obtain a theoretical framework that is more general as possible, two species of high agricultural interest (Drosophila suzukii and Halyomorpha halys) will be considered to validate the various steps of the theory. This research project has a highly innovative approach and has the ambition at large to promote a new philosophy on pest management that goes beyond qualitative analysis and decision making, proposing a quantitative model-based approach to pest management. The research objectives are highly original and focus on aspects of pest management that are highly relevant both from the applied and the research viewpoint. We believe that the research and the tools that will be developed in this research project will have a major impact on both the scientific and the farmers community.

Mots clés : physiologically based models, integrated pest management, pest population modelling, optimal control, precision agriculture, alien species

Participants :
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet WOMLIT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

WOMLIT project aims at challenging the invisible presence of women in Arabic literacy in Congo during the colonial period (1885-1960). The core assumption is that the grasp of salient feature of the participation of Muslim women in literacy is key to understanding Islam in Central Africa, women’s identity, social networks, and major inherent gender and class tensions. This project is mainly designed to address the historical gap on the absence of women in Arabic literacy, aiming to bring new female voices. To reach these goals, and given the significant scarcity of documentation in the field, WOMLIT will adopt a transnational, socio-historical and feminist perspective, combining oral testimonies, archival research and photographic material collected in Congo, as well as in other locations (Rwanda, Burundi, Tanzania, including Zanzibar) and in the Arabian Peninsula (Sultanate of Oman). The project will address the extent to which Muslim women’s practices in other Swahili areas can be transposable to Congo, and vice versa, addressing their participation in Sufi Brotherhoods (Qaradiyya), Umwali (sexual initiation) and magic. WOMLIT will analyse how the question of archives and the voices they reveal is a fundamental issue for feminist theories. This project aims to add new perspectives on the history of the Congo, as well as the history of Oman whose presence in Congo remains silenced compared to its influence in East Africa. WOMLIT is closely related to the research led by the researcher's supervisor Xavier Luffin and his team on Arabic literacy in Eastern Congo, Burundi, and Rwanda during the colonial period, part of a 4-year project funded by the Fonds de la Recherche Scientifique (FNRS, Belgium), that will greatly benefit the fellow.

Mots clés : congo, arabic literacy, arab swahilis, oman, colonial, women s invisibility, gender, archives, oral history, muslim practices, islam, sufism, religion

Participants :
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet GENDERUJ (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Pursuant to universal jurisdiction, core international crimes (genocide, crimes against humanity and war crimes) are increasingly being adjudicated before domestic courts. Practitioners have, however, questioned their ability to form appropriate sites of gender justice. Indeed, domestic courts appear to encounter significant substantive, procedural, and institutional issues when prosecuting sexual and gender-based international crimes (SGBC). While academic debates have theoretically examined the rationale, legality, and politics of universal jurisdiction, its actual practice has received limited attention. Particularly, a robust academic study exploring the practical manifestations of gender justice – if any – in universal jurisdiction proceedings is yet outstanding. Through a comparative socio-legal case study of the law and practice of three EU Member States (Belgium, France, and Germany) and one non-EU State (Canada), GENDERUJ will investigate the ability of domestic courts to respond to challenges posed by SGBC. Building on the rich feminist scholarship engaging with gender justice in international criminal law, the project will decipher whether norm transfer from international to national legal systems is possible. Ultimately, GENDERUJ will provide valuable theoretical and practical contributions to the domestic application of international criminal law. Conducted under the supervision of Professor Damien Scalia at Université libre de Bruxelles, GENDERUJ will combine legal and sociological methods (actor mapping and semi-structured interviews). It will mobilise diverse fields of research, such as law, criminology, and victimology, and include a three-month secondment at the International Centre for Comparative Criminology of Université de Montréal. Bringing new subject knowledge as well as enhanced research and complementary skills, GENDERUJ will prepare the ER to lead a research group, obtain a tenure-track position and/or advanced funding.

Mots clés : international criminal law, universal jurisdiction, sexual and gender based crimes, sexual violence, gender justice, criminal procedure, criminal law, feminist approaches, socio legal studies

Participants :
- Université de Montréal (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200400.0 €