Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SINTER (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

As a Maria Skłodowska-Curie Fellow, I aim to develop a self-driven bone transport nail to reconstruct large bone defects caused after trauma or tumour removal. This is to overcome the current limitations of bone transport techniques that use intramedullary nails. These are: daily involvement of patients during the distraction process, regular interventions by surgeons and the significant cost of the procedure. These limitations have led to limited use of this method regardless of its superior outcomes compared to other commonly used techniques. It is becoming more popular now as it overcomes limitations of external fixators: a prolonged treatment time, diligent care, as well as psychological, hygiene, and daily activity burden for patients and caregivers. Automating the process and reducing its cost, can considerably promote the use of the nails. Under the supervision of Prof. Anthony Bull, a world leader in translational low-cost medical devices and musculoskeletal biomechanics at Imperial College London, I aim to overcome this translational barrier by developing a novel distraction mechanism. I will optimise the nail using a spring-piston system to achieve the optimised distraction rate for bone reconstruction. The unique design of the nails allows manufacturing by traditional processes as well as additive manufacturing. Given the type of trauma and tumour, the defect could be developed at different places in the bone. Therefore, surgical and technical considerations will be taken into account in collaboration with Mr Craig Gerrand and Mr Pierluigi Cuomo, world leaders in bone cancer/transport surgery, during a secondment at the Royal National Orthopaedic Hospital. This project will develop the first self-driven intramedullary nail for bone transport. This nail is not only advantageous compared to the available ones but also a low-cost option that can make this technique more affordable and available worldwide, particularly in Low- and Middle-Income Countries.

Mots clés : medical devices, bone reconstruction, bone transport, intramedullary nail

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet FiTTeR (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

As a Marie Skłodowska-Curie Fellow, I will develop, characterize, and determine the efficacy of a biomaterial platform to target pathologic fibrosis and promote tissue repair following myocardial infarction (MI). I have an ideal background and will perform well in this project based on my expertise in extracellular matrix (ECM) derived biomaterials, characterizing the immune response to biomaterials, and evaluating in vivo outcomes. The proposed system will consist of a protein fragment tethered to an injectable hydrogel. The hydrogel carrier will be composed of ECM, which has been shown to facilitate tissue repair processes by local modulation of immune cell phenotype . The cryptic protein fragment, recently isolated and recombinantly produced by the Stevens Group , has gained attention for its ability to regulate the onset of fibrosis by interfacing with cells to abrogate the release of matrix metalloproteinases (MMPs). No therapies currently exist to prevent or mitigate fibrosis. Developing a sophisticated delivery system for a cryptic protein fragment will enable the broad potential of targeting pathologic fibrosis to be realized. This system will be advantageous in simultaneously providing localized delivery, combined immunomodulatory and regulatory properties of the ECM and recombinant protein fragment, and sustained release of the protein fragment during degradation of the ECM hydrogel. The combination of my expertise (in ECM hydrogels, characterizing the host response to biomaterials, and translating technologies) and Prof Molly Stevens’s supervision and world-class interdisciplinary biomaterials-focused group, the 2014 Research Group of the Year (European Life Science Awards), at Imperial College London (ICL), together make this project ideally suited for success.

Mots clés : extracellular matrix, myocardial infarction, fibrosis, cell biomaterial interactions, tissue engineering

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet BROAD (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

As a consequence of reforms of the social security systems in the EU, consumers increasingly face numerous investment decisions that involve risk, such as how to allocate their retirement savings between risky and safe assets. However, consumers often fail to make optimal choices. A key aspect in this context is whether and how people integrate (or “bracket”) the many different choices under risk they face. Evidence suggests that people often bracket narrowly, i.e., they view each choice in isolation and not in the context of the other choices they face, thereby often making choices that are not in their best interest. Understanding what determines how people bracket their choices is therefore of crucial importance. An important open question is whether people can (be induced to) “learn” to bracket broadly through a clever design (or “framing”) of the decision environment. I will investigate this question in a laboratory experiment to establish the scope and limits of learning to bracket broadly. Making the insights transferable across contexts and institutional features requires knowledge about the cognitive mechanisms of this learning. I use recent advances in neuroeconomics to gain a better understanding of these mechanisms using functional magnetic resonance imaging. The project will build on my initial experience in research on choice bracketing and complement this with the existing strengths in behavioral economics and neuroeconomics, as well as, the excellent research and training infrastructure at Maastricht University. The insights gained will lead to a better understanding of how individuals deal with multiple decisions involving risk and “the way consumers understand and choose financial services” (European Consumer Agenda). The project will contribute to the design of policy interventions that help consumers make better decisions via a grant proposal with an industry partner and comprehensive dissemination and communication activities.

Mots clés : choice bracketing, myopic loss aversion, risk, investment, framing, behavioural finance, neuroeconomics

Participants :
- Maastricht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet DENVPOC (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

As a result of Global climate change and fast urbanization, global outbreaks of Dengue (DENV)/ Zika(ZIKV)/Chikungunya(CHIKV) virus have the potential to occur. The most common pathway of these infections in humans is through the female Aedes mosquito vector. DENV is an exanthematous febrile disease with varied clinical manifestations and progressions . Due to similarities in symptoms between DENV and ZIKV and CHIKV, it is difficult to make a differential diagnosis, impeding appropriate, timely medical intervention. Furthermore, cross-reactivity with ZIKV, which was recently related to microcephaly, is a serious issue. In 2016, in Brazil alone, there were 4180 microcephaly cases reported instead of 163 cases, more in line with yearly expected projections , , Thus, the sooner an accurate diagnostic which differentiates DENV from the other manifestations is critical; most especially at the early stages of the infection, to have a reliable diagnosis in pregnant women. In 2016, the OMS emergency committee declared that the outbreaks and the potentially resultant neurological disorders in Brazil were an important international state of emergency in public health, as a result of the associated secondary effects; these diseases became a Global concern. This project allows developing a highly and fast Multiplex qPCR POC platform by using FASTGENE technology with a minimal amount of patient serotype. It would reduce the time of analysis (30 to 90’ for a standard) and costs. Additionally, the sample preprocessing and thermalization will shorten real-time PCR amplification time and will be integrated within the microfluidic systems. This platform can result in a commercialized product whereupon a main market target would be pregnant women and people living or traveling through/from outbreak risk areas.

Mots clés : microfluidics, dengue diagnosis, point of care, qpcr

Participants :
- Bforcure (France) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 196707.84 €
Projet SkinForce (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

As a self-renewing organ maintained by multiple distinct stem cell populations, the epidermis represents an outstanding, clinically relevant research paradigm to address mechanisms of stem cell regulation. To achieve the dynamic turnover and maintenance of the critical skin barrier function, epidermal stem cells (SC) commit to differentiate and delaminate from the basal layer to form suprabasal layers. What triggers SC differentiation, how the differentiating cells move upwards, and how differentiation and self-renewing divisions are balanced remain key open questions. Cells within the epidermis are constantly exposed to tissue- and cell-scale forces that result in changes in cell and nuclear shape and volume. Based on the emerging role of cell density and size in regulating SC fate, I hypothesize that dynamic nuclear and cell shape changes play central roles in regulating epidermal SC fate and in coupling fate changes to cell positioning within the tissue. By combining an innovative, live embryo imaging pipeline, quantitative image analysis, and theoretical models, I aim to decipher the dynamics of epidermal morphogenesis. Using transgenic reporter mice for the nucleus, plasma membrane, cytoskeleton, and differentiation, I will map large-scale and local mechanical transitions along the developmental timeline and correlate them with nuclear and cell shape changes, cell division, differentiation and delamination. I will combine these quantitative imaging experiments with computational modeling, genetic manipulation of contractility, spatial single cell transcriptomics and in vitro cell biology to discover the cellular and molecular mechanism by which tissue geometry and cell/nuclear shape guide cell fate and dynamic positioning. Altogether, this project will uncover fundamental mechanisms of epidermal stratification during development and homeostasis.

Mots clés : tissue mechanics, nuclear deformation, epidermal stratification

Participants :
- Max Planck Society (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 58338.96 €
- University of Helsinki (Finlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 122353.62 €
Projet TIME_FOR_SHADE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

As arable land becomes scarcer and the human population continues to grow, we need to focus our efforts on increasing yield. The goal is to rethink agriculture to ensure food security. One way to do so is to lower yield loss due to light limitation by neighbouring shade or high-density planting. Phytochrome (phy) photoreceptors play a critical role in plant survival under vegetation shade conditions, by initiating a switch to a shade avoidance response (SAR) growth strategy. Although SAR reconfigures overall architecture for optimal light capture, it results in elongation of growth of stem-like tissue, at the expense of harvestable organs. Central to this adaptive response is an interaction between the plant's internal circadian clock and the phy pathways which restricts or gates the response to dusk. As the clock was previously shown to have a general role in optimising fitness, this proposal will establish whether circadian gating of SAR confers a fitness advantage and delineate the underlying molecular mechanisms that link the clock to altered leaf cellular responses under SAR. Bioluminescence reporters, optogenetic tools and the PS-plant 3D imaging platform will enable the capture of dynamical data from molecular to whole plant levels. Further, pennycress, a novel oilseed crop and a close relative of Arabidopsis will be developed as a model to facilitate the direct translation of novel findings in this proposal, to increase plant fitness and yield to this new crop species.

Mots clés : circadian clock, gating, phytochrome, light signalling, shade avoidance, arabidopsis, leaf, leaf growth

Participants :
- Utrecht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187572.48 €
Projet COFFEE (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

As can be seen in the history of science, new techniques and methods open new research fields. In this project, the authors propose to use a new methodology approach to study thin layers of condensed matter and surfaces. We aim to perform Attosecond Transient Absorption Spectroscopy combined with femtosecond Transient Grating to study ultrafast time evolution of a model sample – solid krypton. We identify our major objectives as work packages: WP1: Attosecond XUV Transient Absorption Spectroscopy of gaseous krypton. WP2: Attosecond XUV Transient Absorption Spectroscopy in the condensed phase, the example of solid krypton. WP3: Condensed phase Transient Grating spectroscopy in the XUV spectral range with attosecond resolution. All experiments will be performed by O. Hort PhD within the Ultrafast Laser Group led by Prof. A. Baltuška (Photonics Institute, the Vienna University of Technology, Austria).

Mots clés : attosecond transient absorption spectroscopy, transient grating, few cycle pulses, solid krypton, ac stark shift

Participants :
- TU Wien (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166156.8 €
Projet papabuild (Horizon 2020, appel à projets 2015)
Action : Staff Exchanges
Panel : Physics
Statut du projet : CLOSED

As clearly stated in report no. 10/2014 "Noise in Europe 2014" by the European Environment Agency, noise pollution is a major environmental health problem in Europe, yet the lack of comparable common assessment methods causes significant inconsistencies in exposure estimates of people affected by noise. However, in the past few years building acoustics has been influenced by evolution issues in terms of new acoustics requirements focused on sound insulation at low frequencies (reflected in proposals in the ISO 140 family), and by improving the single-number quantities (ISO 717) which would correlate better with subjective perception of sounds transmitted through building structures. The proposed project aims at (1) improving the diagnostic methods for more precise determination of physical properties of building elements (ISO140), (2) involving subjective assessment of sound insulation to help propose a suitable single number quantity (ISO 717), and (3) enabling sustainable product innovation as the result of improved diagnostic methods. First and foremost, novel acoustic measuring techniques, specifically, Laser Scanning Vibrometry and acoustic cameras, will be applied for developing novel diagnostic procedures. Second, noise perception tests will be developed using advanced, full 3D sound field recreation techniques. Single number quantities will be proposed to reflect perceived annoyance by noise, with the extension to low-frequency range <100 Hz. Finally, these advancements will be used for innovative design of building elements with improved sound insulation. This will have a lasting impact on collaborating partners of the consortium, both on universities, whose task will be to implement the research findings in practical solutions connected to noise abatement for raising living comfort, and SMEs, who will gain knowledge for innovation in design of sound insulating building elements and learn new methods for a precise detection of sound insulation deficiencies

Mots clés : acoustic noise, physical acoustics, psycho acoustics, building acoustic, comfort, noise related deseases

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 45000.0 €
- Slovak University of Technology in Bratislava (Slovaquie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 157500.0 €
- Specijalni proizvodi od drva fran doo (Croatie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 108000.0 €
- A & z acoustics sro (Slovaquie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 153000.0 €
- Exel rudolf (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 31500.0 €
- University of Zagreb (Croatie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 121500.0 €
- Federal Ministry of Education, Science and Research (Autriche) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 63000.0 €
Projet BANYAN (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : SIGNED

As mobile services consumed by people and machines become increasingly diversified and heterogeneous, 4G/5G networks are asked to meet a growing variety of Quality of Service (QoS) requirements. Network slicing, enabled by Network Function Virtualization (NFV), is a promising paradigm to increase the agility and elasticity of the mobile network via logical slices that can be formed and composed dynamically, so as to adapt to the fluctuations in the demands for different mobile services. A key enabler for network slicing is accurate data-driven models and the prediction of the spatio-temporal dynamics of the mobile service traffic, which allow discovering knowledge relevant to the orchestration of slices and anticipating the need for their reconfiguration. The need for effective data-driven slice management is especially critical in proximity of indoor Radio Access Network (RAN), which must accommodate most of the volume and variations in the demand associated to each mobile service and whose performance is crucial to user QoS. The BANYAN project is designed to address major open issues towards the realisation of data-driven 5G RAN, as follows: - Modelling and forecasting macroscopic high-dimensional mobile traffic patterns observed at RAN for individual services, at multiple scales in time and space; - Geo-locating and characterising in-building mobile traffic patterns observed at RAN; - Designing data-driven strategies for the allocation of 5G RAN resources; - Designing data-driven policies for the orchestration of 5G RAN resources to suit service requirements and dynamics via network slices; - Coordinating outdoor and indoor heterogeneous networks to meet user QoS requirements. To address the research objectives above, BANYAN pursues a tight academic-industrial cooperation, which will allow developing key tools for data-driven 5G RAN, as well as properly training early-stage researchers who are urgently needed by industry, academia, etc.

Mots clés : big data analysis, radio access network

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Partner, beneficiary, Recherche, subvention : 501809.76 €
- National Research Council (Italie) — Partner, beneficiary, Recherche, subvention : 319610.72 €
- Ranplan wireless network design ltd (Royaume-Uni) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 538973.44 €
Projet MolNANOtox (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

As nanotechnology continues to advance at an exponential rate, new products are continuously introduced into the market for research and consumer use. Engineered nanomaterials (ENMs), the functional components in these products, are often specifically designed to exploit the unique properties that nanomaterials exhibit; however, there is a widespread uncertainty on how these new properties may also potentially translate into novel risk issues in the environment. In particular, their high specific surface area and surface reactivity may promote distinct interactions with organisms particularly at the lower trophic levels. This can depend on both the intrinsic and extrinsic properties of ENMs, and can be affected by the formation of an “eco-corona”, which is composed of environmentally derived macromolecules from the milieu in which the ENMs are exposed that adsorb to the ENMs surface. However, understanding these interactions at the molecular level and their mechanistic consequences are severely limited and technically challenging, requiring a cross discipline approach. This project aims to address this knowledge gap by uncovering the underlying mechanisms for the formation and persistence of eco-coronas on a range of ENMs by combining fundamental ENM chemistry, environmental toxicology, advanced optical and mass spectroscopy and imaging techniques. In particular, this project will apply surface enhanced spectroscopic methods to characterise eco-corona composition and evolution and how this affects ENM interactions with, and impact upon unicellular organisms. By correlating the eco-corona composition with uptake route (or accumulation at external membrane) and toxicity response, and by investigating how these ENMs are partitioned within model species, the project proposes to identify the molecular basis that determines the fate and toxicology of ENMs in the environment.

Mots clés : nanotoxicology, ecotoxicology

Participants :
- UK Research and Innovation (Royaume-Uni) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 195454.8 €