Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet GRACE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Biogas is a renewable energy source that contributes to carbon-neutrality by reducing GHG emissions. An EU-wide climate policy framework supports a circular economy based on biomethane. Yet, biomethane is largely contaminated with CO2 that must be removed. A promising method for biogas upgrading benefits from the use of solid adsorbents, cutting down 40% in sorbent regeneration costs compared to the use of decades-old liquid amine absorbents, which suffers from poor chemical stability and high regeneration energy costs. How can GRACE contribute to the global effort towards the design of future-generation sorbents with improved CO2/CH4 separation? GRACE aims at providing answers to this end by rationale materials’ design that will help to build an atomic-level understanding of intermolecular interactions at the gas-solid interface governing thermodynamic/kinetic phenomena at sorbent surfaces. The scarcity of atomic-scale studies in gas-sorption mechanisms at porous surfaces has hindered further progresses on the synthesis of better CO2-adsorbent materials. This knowledge gap is thus my major motivation. To tackle this challenge, GRACE encompasses 3 main goals: 1) design sustainable periodic mesoporous organosilica (PMO) sorbents; 2) obtain structure-property relationships studying gas-sorbents at the atomic level; 3) test distinct PMO grain shapes for better biogas upgrading under industrially-relevant operating conditions. My past expertise in materials’ design and multidisciplinary characterization skills will be a valuable asset not only for the synthesis of viable sorbents with favorable properties for CO2/CH4 separation but also for the tandem use of operando TGA-IR, NMR/DNP spectroscopies and gas adsorption to study confined 13C-enriched CO2 species (using pure CO2 or gas mixtures). This equipment is hosted at CICECO-UAVR, an internationally renowned lab that fosters interdisciplinary research and is committed to support the growth of young researchers.

Mots clés : periodic mesoporous organosilicas, co2 ch4 adsorption separation

Participants :
- Université d'Islande (Islande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Fondation pour la recherche scientifique et industrielle (Norvège) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université d'Aveiro (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
Projet HorLumAS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Live Visual Investigation of Hormonal fluxes upon Abiotic Stress in Arabidopsis using Bioluminescence


Participants :
- Institute of Experimental Botany (Rép. Tchèque) — Coordinator, beneficiary, Recherche, subvention : 172278.72 €
Projet GEM-SBP (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Shelf-to-basin sedimentary processes entail intricate interactions between the ocean sub-mesoscale and the near-seafloor sediments. These processes hold significant multidisciplinary importance, given their ecological impact, relevance to marine geo-hazards, and role in shaping continental margins and global climate. However, there's a gap in quantitative tools to model and characterize these processes simultaneously considering oceanographic and near-seafloor sediments properties. In GEM-SBP I will use ultra-high-resolution seismic reflection data (UHRS) to create a set of modelling techniques able to couple both domains. The Southeastern Levant Basin (SLB) will serve as a natural laboratory for studying the interaction between the sedimentological and oceanographic domains. This semi-enclosed basin features a single sediment source and a multitude of morphologically complex features formed by sediment transport mechanisms. I will first develop novel seismic processing workflows tailored for ocean and near-seafloor sediments imaging that will consistently yield a seismic image depicting both domains and their interaction. I will then develop and implement an iterative geostatistical seismic inversion procedure able to invert the processed UHRS for high-resolution ocean (i.e., temperature and salinity) and near-seafloor geotechnical models. I intend to leverage the most recent advances in deep learning to build a spatial regression model and predict these properties in 3-D by integrating spaceborne earth observation data. Our models will provide insights into the sediment transport mechanisms dynamics and will pave the way for a new set of methodologies for studying these phenomena on a global scale. I intend to raise society's awareness about the global impact of oceanographic and seafloor processes, through outreach, communication and dissemination activities aiming to foster a multi-stakeholder environment (i.e., industry, academia and public) within the project.

Mots clés : ultra high resolution seismic shelf to basin processes seismic oceanography geostatistical inversion

Participants :
- Université de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
Projet RESPONSE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Cytokines, such as TNF-α, hold immense significance as protein biomarkers, pivotal for diagnostic, prognostic, and therapeutic management across various clinical disorders like Alzheimer’s disease, sepsis, and cancer. Nonetheless, prevailing techniques like enzyme-linked immunosorbent assay (ELISA) and Polymerase Chain Reaction (PCR) prove to be expensive, time-intensive, and reliant on specialized personnel, intricate instrumentation, and infrastructure. Furthermore, the performance of present biosensing techniques necessitates refinements in terms of real-time outcomes, sensitivity, affordability, and user-friendliness. Within this context, the RESPONSE project sets out to forge an innovative approach, intertwining Janus graphene derivatives (JGDs) and Single Atom Catalysts (SACs), or atozymes, for Point-Of-Care (POC) biosensors for cytokine detection. This undertaking involves the strategic utilization of selectively and densely functionalized JGDs, serving dual roles: i) as signal transducer immobilized on a paper lateral flow electrochemical sensor (LFES), and carrying the cytokine bioreceptor (primary/capture antibody; Ab1) and ii) as signal amplifier JGDs, housing the SACs and the secondary/signal antibody (Ab2), which binds to a different epitope of cytokine. The binding between TNF-α and JGDs-Ab1 initiates the sandwich formation with SAC-JGDs-Ab2 complex at the test region. Here, the SACs catalyze the oxidation of an appropriate reporter molecule, liberating electrons and thereby significantly amplifying the signal output which can be quantified through an integrated electrode system. REPSONSE offers affordability, point of care readiness and commercialization potential. Importantly, RESPONSE’s strategy defines the blueprint for transitioning from the current, symptom-focused and late-stage diagnosis to the next-generation prognostic biomarker-guided preventative or therapeutic treatment management, and improve life-quality of millions of people worldwide.

Mots clés : atozymes, janus graphene, bioreceptors, electrochemical sensor, microfluidics, cytokines

Participants :
- Université Palacký (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166278.72 €
- Catalan Institute of Nanoscience and Nanotechnology (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet OMRP (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

O-GlcNAcylation is a post-translational dynamic modification of proteins that is becoming more widely recognized as a modification that can protect proteins from pathological aggregation in neurodegenerative diseases. However, it is unknown how this modification influences the RNA binding properties of the protein and its function. In the proposed project I will study the O-Glc-NAcylation of RNA-binding proteins (RBPs) associated with amyotrophic lateral sclerosis (ALS), and its effects on the RNA binding properties and thereby on the regulation of RNA processing. I will find O-GlcNAcylation sites of TDP-43, Fused-in-sarcoma (FUS), Ewing sarcoma protein (EWS), and TATA-box binding protein associated factor 15 (TAF15) and I will assess the increased amounts of modification after stimulation of the cells with high glucose or with O-Glc-NAcase inhibitor. I will study if their RNA interaction profiles change with increasing amounts of O-Glc-NAc modifications in differentiated cortical neurons. Later, I plan to implement in the company, a mass spectrometry method adapted to analyse the ALS-liked RBPs proteins, which will help the glycoscience community. This project will expand our understanding of the molecular mechanism of transcription regulation through protein O-Glc-NAcylation and can provide the necessary knowledge to understand ALS-related proteinopathies.

Mots clés : o glc nac, o glc nacylation, rbps, als, rna interactions, rna splicing, iclip, glycosylation

Participants :
- Institut Francis Crick (Royaume-Uni) — Partner, associated partner, Recherche, subvention : 0.0 €
- Genos (Croatia) (Croatie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut de Chimie (Slovénie) — Coordinator, beneficiary, Recherche, subvention : 168522.64 €
Projet ROMSUR (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Increasing urban traffic and environmental challenges have driven the investigation, development, and diversification of sustainable transportation alternatives globally. The resilience of these alternatives has also been considered equally important in recent research in order to ensure a more safe, accessible, and equitable transportation system during severe disruptions. However, there is a lack of comprehensive evaluation system through which urban and transportation planners can assess and plan for transport resilience in their own geographical contexts. In this regard, this research proposes a model to evaluate an overall resilience of shared micromobillity systems through their commonly available usage patterns in light of current challenges and future opportunities. Specifically, it takes major shared micromobillity programs (e.g., station-based bike-sharing (SBBS), free-floating bike-sharing (FFBS), free-floating e-bike sharing (FFEBS), and free-floating e-scooter sharing (FFESS)) operating in Europe as examples to empirically analyze the mobility patterns of their users across three timescales: before, during, and after the pandemic. As a methodology, this study will utilize a combination of quantitative and qualitative techniques. The expected outcomes will help in improving governance and an appropriate appraisal of sustainable urban transport alternatives, which are still in its infancy. The resilience assessment tool will further help develop long-term systems for measuring and executing mobility plans on both sides of the mobility equation: supply and demand.

Mots clés : shared micromobility transport resilience mobility as a service urban sustainable active mobility covid 19 europe

Participants :
- Université Masaryk (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166278.72 €
Projet YUCARE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The onset of World War II saw an unprecedented number of Yugoslav women join the Partisan forces in the National Liberation Struggle (NOB). In order to build support amongst conservative rural populations, Partisan forces relied on the appropriation of traditional gendered structures, leading to the creation of a complex medical infrastructure heavily reliant on the participation of women. Whereas contemporary scholarship has primarily focused on the histories of women combatants or of women’s political organization, little attention has been paid to the largest demographic of Partisan women: the doctors, nurses, pharmacists and auxiliary staff tasked with caring for the sick and wounded. The MSCA project YUCARE traces the biographies of five notable women medical workers, using their wartime trajectories as a starting point for discussing the diversity of experiences encompassed within the sanitet. The project addresses two central questions: focusing on the overlooked experiences of women in the Yugoslav Partisan Medical Corps, it explores the divergences between accepted narratives and individual experiences to integrate temporal, geographic and demographic differences into a broader gendered history of World War II. Secondly, it explores how traditional gendered structures were maintained, challenged and negotiated within the Partisan army, and how these contributed to the state-building practices of the fledgling socialist state. This empirical objective is compounded by the combination of a microhistorical methodology with digital history tools, building on actor memoirs and a unique collection of archival materials to evaluate and communicate results in a web-based map format. By acquiring new skills in database management and virtual mapping, YUCARE will enable me to reach my desired specialization in digital historical communication while grounding myself professionally in my region of study.

Mots clés : world war ii, yugoslavia, national liberation struggle nob , women partisans, social history of war, military medicine, care labor, microhistory

Participants :
- Institut za novejso zgodovino (Slovénie) — Coordinator, beneficiary, Recherche, subvention : 182717.52 €
Projet OPTIMAL (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Offshore freshened groundwater (OFG) refers to fluids stored in sediment pores and rock fractures below the seafloor, with a salinity lower than seawater. This phenomenon has been identified globally in continental margins and proposed as a resource that can potentially alleviate water stress in coastal regions. However, the scarcity of data to constrain the distribution and volumes of the reservoirs remains a challenge. OPTIMAL project aims to: (i) develop an interdisciplinary methodology to predict the occurrence and distribution of OFG resources built on Artificial Intelligence and (ii) apply the model globally to infer OFG occurrence and quantify the resource feasibility as a function of distribution characteristics such as offshore extent, depth below the seafloor and fresh to brackish water ratio. The proposed methodology uses a surrogate model to create a dataset of input parameters, representing key geological and geomorphological components influencing OFG systems, such as aquitard thickness and seafloor bathymetry. The output data will be generated via numerical simulation of variable-density groundwater transport on the suite of surrogate models using high-performance computing. These data will be used to train and test machine learning algorithms. The successful models will be validated using real-world data from the existing global OFG database. The predictive model proposed in this fellowship contributes to achieving Sustainable Development Goals related to technologies for improving access to water resources. The primary beneficiary of this funding will be the University of Malta. Partner organizations will be Utrecht University and Deltares in The Netherlands. The action presents a unique opportunity for the fellow to transfer his expertise in stochastic reservoir modelling and characterization of OFG systems to the host, while learning about marine geology, seafloor landforms and applied machine learning.

Mots clés : offshore freshened groundwater, high performance computing, machine learning, geology, geomorphology

Participants :
- Université de Malte (Malte) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 161411.52 €
- Université d'Utrecht (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Deltares (Pays-Bas) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet 3DNanoScope4All (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Contemporary optical microscopy techniques are capable of imaging sub-wavelength (<400nm) structures. However, challenges such as phototoxicity, slow acquisition speeds, and difficulties in extending to 3D imaging have hindered their widespread adoption in live-cell studies. Light field microscopy (LFM) allows 3D imaging of biological samples with a single snapshot, reducing phototoxicity and allowing fast imaging of whole live cells. Recent breakthroughs have demonstrated single-molecule LFM with sub-100nm resolution, offering a straightforward optical design that holds immense promise for integrating complementary methods to study real-time dynamics in live cells without causing damage.  3DNanoScope4All will develop and formalise a highly accessible, high-performance device for live cell nanoscopy. For that, three novel, yet robust, techniques will be merged in a single device: (i) LFM as the core technique, (ii) 3D-SRRF, facilitating high-resolution, rapid measurements and (iii) single-molecule orientation microscopy, providing spectroscopic insights into 3D molecular order. The combination of these cutting-edge technologies will enable both structural and dynamic measurements of live cells in a powerful yet affordable device.  After validation, this nanoscope will be used to reveal previously poorly understood processes involved in the dynamics between viral particles (120nm) and cell membrane interactions during human immunodeficiency virus (HIV) infection. These advancements will not only broaden the current understanding of HIV infection but also pave the way for future research based on super-resolution microscopy techniques applied to other host-pathogen interactions.

Mots clés : super resolution microscopy, single molecule polarization, radial fluctuations, light field microscopy, single molecule, hiv 1, plasma membrane, infection cycle, live cell

Participants :
- Gulbenkian Institute for Molecular Medicine (Portugal) — Coordinator, beneficiary, Recherche, subvention : 127382.58 €
- Université complutense de Madrid (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Cambridge (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet REvoBBIT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The lagomorphs (rabbits, hares and pikas) are a successful mammalian group, which play key roles in many ecosystems (sustaining other species' communities and populations). The ongoing climate change is pushing most of their species into the extinction, and their demise can entail the decline of their communities and ecological systems consequence of a dramatic knock-on effect. The present project, REvoBBIT, aims to contribute to search solutions to this severe challenge from an unexplored perspective in this mammalian group: the Conservation Palaeontology. Through the study of the bone and teeth of extinct lagomorphs, it is possible to reveal the biological strategies and evolutionary shifts of those species or populations that were resilient and survived to past global warmings and coolings. This is a very significant knowledge to be considered in the conservation decision-making process of extant relatives. With this ultimate goal, REvoBBIT will study the extinct rabbits and hares from Sierra de Atapuerca (Pleistocene), which endured important glacial and interglacial periods, using trusty morphological methods and frontier molecular and geochemical techniques. Teeth and postcranial bones will be assessed disclosing their weight, diet, genetic size and diversity, as well as the past environmental conditions where they lived (temperature, humidity, etc.). The subsequent statistical analysis will let to identify the most significant ecological stressors and drivers that were involved in the evolution of lagomorphs. The results obtained in REvoBBIT will be the first step to build a big deep-time database of the lagomorph palaeobiology, and to develop predictive models of biotic response. At present, the significant knowledge gap in the palaeobiology and palaeoecology of this mammalian group prevents that palaeontological data will be considered in the protocol conservation design of extant relatives.

Mots clés : palaeobiology, evolutionary strategies, climate change, mammalia

Participants :
- Biopolis (Spain) (Portugal) — Coordinator, beneficiary, Recherche, subvention : 156778.56 €
Projet THuNB (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This project aims to recover a forgotten meaning of temperament, which can be described as elemental and spiritual. This notion is recovered as the foundation of a new conception of human nature. Indeed, as it will be demonstrated, being seen from its temperament, the human being is immediately placed in communion with Mother Nature, so that the description of its fundamental traits immediately becomes a description of its primal relationship with Nature. In the first part of the project we will reconstruct both the gradual loss of the elemental and spiritual meaning of temperament and its sporadic resurfacing in certain historical moments, with particular attention to the nineteenth century. Meanwhile, in the second part of the project, the results of the previous part will be used to construct a new philosophical-anthropological model, such as to inspire today's debate in philosophical ecology and political ecology. The project aims, therefore, to make new contributions both to the history of thought, recovering a lost conception, and to the political ecological debate, urging decision makers to look deeper into the options of ecological wisdom, by means of a new conception of human nature and its relationship with Nature.

Mots clés : temperament inspiration human nature germanocentrism

Participants :
- Znanstveno-raziskovalno sredisce koper (Slovénie) — Coordinator, beneficiary, Recherche, subvention : 182717.52 €