Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ProDelSys (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The primary goal of this project is to train a talented young researcher, Dr. Marina Zajnulina, with a strong academic background in nonlinear fibre and semiconductor optics, laser physics and general nonlinear-wave theory, through a research programme focused on developing of novel all-optical processing systems based on ultra-short fibre lasers, and their usage in a range of practical applications. There is high demand in ultra-short fibre lasers, because they are highly desirable as light sources due to their flexibility, simplicity and cost-efficiency. The project will include theoretical, experimental, and numerical studies of optical ultra-short pulse generation and propagation in a processing system based on an ultra-short fibre laser with optical feedback. To guarantee an all-over success of the project, several European world-leading academic and industrial (non-academic) partners will participate in the project as secondment hosts and co-hosts and consultants. The success of this project will contribute knowledge to the fields of laser science and technology, and establish an internationally leading position for Europe in the industrial applications relevant to telecommunications, as well as other high-demand fields such as spectroscopy, frequency metrology, and instrument calibration. Further, this project will explore the commercialisation of a novel laser as a processing system and enable a greater market share for fibre laser applications. A long-term collaboration between the Fellow and the host and co-hosts will be established ultimately resulting in a new level of optical processing and laser devices and technologies and enhancing the European leading position in this highly competitive commercial field.

Mots clés : optical processing systems, fibre lasers, laser design and development, optical pulse shaping, machine learning, nonlinear wave theory

Participants :
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet SAFEnano (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The primary goal of this study is to use the state-of-the-art methods to study the changes of engineered nanomaterials (ENMs) during water and wastewater treatment and to evaluate how these changes will affect ENMs fate, toxicity and interaction with other contaminants. It is assumed that the major part of ENMs gets into the environment with wastewater. It is interesting though to study how different conditions of water and wastewater treatment will affect ENMs properties. It is very important because of the changes in the physicochemical properties of ENMs caused by these processes may affect the mobility, toxicity and bioaccumulation of ENMs. Moreover, interaction between ENMs and other contaminants may affect their fate in the environment. These results may completely change our approach related to environmental risks associated with ENMs. In addition, the results may open a new area of research focused on realistic scenario. The achievement of these goals requires an inter- and multidisciplinary approach including environmental nanotechnology and chemistry, ecotoxicology, physics, material chemistry and engineering. These goals will be achieved through the implementation of research in one of the most advanced environmental nanotechnology lab in the world. During the outgoing phase I will be trained in new and powerful research techniques from laboratory experiments, physical and chemical analysis and field mesocosm experiment. During the return phase both groups will establish a collaboration, share theoretical and experimental expertise, and possibly initiate a long-term student exchange program. Beside of resolving very important environmental scientific issue, this fellowship will give me the opportunity to work with experts, will create a network of international collaborators, and will co-lead a 3-year long project with increased responsibilities in its conception, design, implementation, administration, and dissemination.

Mots clés : nanoparticles, contaminants, disinfectants, wastewater, treatment, toxicity, water

Participants :
- Maria Curie-Skłodowska University (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 245361.6 €
- Duke University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet iRhomADAM (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The primary inflammatory cytokine, TNFalpha, is a transmembrane protein that requires cleavage by the metalloprotease ADAM17 for its release. Aberrant release of TNFalpha is a hallmark of cancer, chronic inflammation and autoimmune syndromes. The rising prevalence of these widespread diseases necessitates new approaches to manipulate inflammatory signalling, which is the overarching goal of this proposal. Recent studies demonstrate that iRhoms regulate trafficking, maturation and stability of ADAM17. Without iRhoms, TNFalpha shedding is abolished. The aim of this research is to dissect the transmembrane interaction between iRhom2 and ADAM17, which will support the required information to design the first iRhom inhibitor. Using FRET spectroscopy and ADAM17 activity assays, I will first search for essential residues at the transmembrane interface between iRhom2 and ADAM17. Next, I will use rationally designed helical peptides to competitively inhibit the transmembrane interaction. Last, I will test the effect of any inhibitors I develop in an in-vivo human macrophage model and use it to study the significance of this interaction. This study will provide an important mechanistic understanding of iRhom biology, with an emphasis on their mode of specific transmembrane recognition. Moreover, by developing the first specific iRhom2-ADAM17 complex inhibitor, I will establish iRhom2 and ADAM17 as therapeutically relevant targets to manipulate inflammation.

Mots clés : rhomboids, pseudoenzymes, irhom, adam17, tace, tnfalpha, membrane proteins, protein protein interactions

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet BNL (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The primary visual cortex of the mouse is an ideal model system in which we can study network restructuring during learning, due to the well-described functional properties of its neurons, the existence of a robust learning paradigm, and the feasibility of recording large populations of neurons. Here we aim to identify functional groups of cortical neurons based on the robust estimation of their correlations and observe the topological re-structuring of the network they form. We will build comprehensive Bayesian multi-level models that respect the multidimensional structure of the data for estimation and interpretation of our results. We hypothesize that we will observe major re- structuring of functional cortical sub-networks upon learning.

Mots clés : cortex learning in vivo excitatory inhibitory networks graph theory

Participants :
- Foundation for Research and Technology Hellas (Grèce) — Coordinator, beneficiary, Recherche, subvention : 165085.44 €
Projet SiPhoN (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The principle of non-locality is one of the most impressive features of quantum mechanics. Usually, non-locality is related to two or more particles sharing a common characteristic. This quantum mechanical effect is well understood and several experimental demonstrations have been performed. However, non-locality of a single particle, in particular of a single-photon raises fundamental questions: Can a single-photon be simultaneously at different locations? In spite of numerous theoretical concepts, no clear experiment has yet been reported. In this project, I will experimentally prove the non-local nature of a single-photon. To this end, I will create on-demand single-photons from nanowire quantum dots and measure the single-photon non-locality in a new homodyne detection scheme. This combines several future key technologies ranging from novel quantum light sources to superconducting materials, making the proposed research of broad interest in the European research community. In addition, this project will enable Single Quantum B.V. (the only European company developing superconducting detectors and in competition with Russian and US companies) to perfect their detection systems and optimize them for the emerging market of quantum optics applications that is expected to turn into a large market in this century. A successful realization of the proposed research relies on four pillars: Resonance fluorescence (applicant: Dr. Joens), bright single-photon emitters (supervisor: Prof. Zwiller), efficient detectors (partner: Single Quantum B.V.), and the theoretical understanding of non-locality (host: KTH). Every single party contributes with its unique expertise to the big picture. This makes the proposed constellation of participating organisations essential for the success of the project. Together we will finally answer one of the fundamental questions in quantum mechanics: Single-photon non-locality.

Mots clés : quantum dot, nanowires, single photon, quantum interference, non locality

Participants :
- KTH Royal Institute of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173857.2 €
Projet IBridge (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The privatization of public land is a global challenge, as public land is for public services. This long-lasting challenge of public policy and consequently of the architecture of public space reminds us the architectural type of inhabitable bridge as traditional walled-off paths and gated communities in Early Modern (EM) Europe, which mediated between public and private territories, as a city on itself, a dualism of connectedness and separation. I shall, therefore, conduct a case study of the inhabitable bridges (IBs), which specifically will reveal the emergence of public privacy (PP) beyond the privatization of public paths in IBs, called "Inhabitable Bridges in a Privacy Perspective" (IBridge), focusing on EM Europe since the public privacy fostered. Utilizing the two important examples in terms of location and size, the demolished Old London Bridge and the Pont de Notre-Dame in Paris, I will analyze how public policy developed these bridges in terms of public and private ownership and what the architectural and social effects of this development were. The remaining challenges in the public realm require a focus on their historical background in EM architecture and policy to find concerns and values. An analysis of the interconnectedness of the IBs' architecture and PP values will help us understand the impact and relations between political agents, spatial organization, PP attitudes in EM Europe. In this way, IBridge recalls the challenges and values of the EM European public realm that cultivated distinct ways of providing PP that strongly linked to both the political and cultural sphere, drawing on earlier lessons for public comfort in urban scenes. The Royal Danish Academy, Schools of Architecture, Design and Conservation (KADK), Center for Privacy Studies (PRIVACY) at Copenhagen University, and Institute for the History and Theory of Architecture (GTA) at ETH Zürich serve as an excellent host to IBridge, as their focus is on architectural and privacy studies of EM European cases led by an interdisciplinary board and scholars.

Mots clés : privacy, public realm, inhabitable bridge, early modern europe, architecture, urbanism, old london, bridge, pont de notre dame, interdisciplinary, gender

Participants :
- Royal Danish Academy – Architecture, Design, Conservation (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 328968.0 €
Projet SDchirnanocat (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The production of fine chemicals, such as chiral molecules, is one of the main applications of the chemical industry. However, any new process developed should be environmentally sound. Metallic nanoparticles (MNPs) have attracted a large interest as catalytic materials due to their small size and high surface to bulk metal ratio, which leads to a greater catalytic activity. These catalysts are easily recyclable, although stabilizing agents are required to prevent agglomeration. In this context, ionic liquids (ILs), salts with melting point <100 ºC, can act both as stabilizers and as solvents. Moreover, MNPs may be immobilized in this medium, allowing the separation of the products and the subsequent recycling of the system. However, ILs are not “innocent” media and can impose a high degree of directionality over the substrates. The employment of chiral ILs adds a new advantage: its potential use in asymmetric catalysis to induce the formation of chiral products. In this project we will merge the asymmetric properties of newly synthesized ILs with the catalytic activity of MNPs. Instead of classical chemical methods, MNPs in ILs will be obtained by sputtering-deposition (SD), an innovative physical technique which enables the fast synthesis of clean MNPs, avoiding the use of organic solvents and reducing agents. In contrast to other physical techniques, the SD of MNPs onto ILs allows the control of the size and shape of MNPs by the appropriate tuning of the sputtering conditions. These three concepts (MNP, chiral IL and SD) converge into the main aim of this project: The development of a novel chiral catalytic system based on MNPs prepared by SD onto chiral ILs for asymmetric hydrogenation reactions. SDchirnanocat will contribute to broaden the fellow competencies and will place him in an excellent position to start an independent career.

Mots clés : sputtering deposition, ionic liquids, metallic nanoparticles, asymmetric catalysis

Participants :
- University of Nottingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet SUPRABARRIER (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks - Industrial Doctorates
Panel : Chemistry
Statut du projet : CLOSED

The production of the next generation of oxygen-barrier polyolefins materials capable of meeting the current and future demands of society in a sustainable manner will require both new technologies and highly trained scientists. Supramolecular chemistry provides a powerful approach to develop new materials with emerging properties, such as low permeability to oxygen, maintaining easy processing. The SUPRABARRIER EID ITN will train a new generation of European scientists with the skills necessary to overcome such future demands and simultaneously develop new strategies for the production of new polymeric systems, which greatly impact important fields such as food and medical packaging. The EID proponents are experts in the areas of supramolecular chemistry and polymer production. Expertise of the partners encompasses the general areas of supramolecular and polymer chemistry, with individual research competencies focusing on a number of specific themes including non-covalent chemistry, supramolecular interactions, polymer blending, polymer processing, polymer production, and Life Cycle Assessment (LCA) analysis and characterisation techniques of complex polymeric and self-assembled materials. The complementarity and diversity realized in synthesis, analysis, development, production and applications is crucial for successful research, innovation and training in this area. The partner from the private sector will extend the fellows’ training beyond that of traditional academic settings, in particular he will have the critical role of bridging fundamental science with application and commercialisation of the results. Our activities will thus possess both breadth and quality that can only be achieved through an interdisciplinary Academy/Industrial European effort.

Mots clés : molecular recognition, oxygen barrier, polyolefins, hydrogen bonding, velcrands, life cycle assessment

Participants :
- Eindhoven University of Technology (Pays-Bas) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Cambridge (Royaume-Uni) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Parma (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 258061.32 €
- Saudi Arabia Basic Industries (Netherlands) (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 255374.28 €
Projet BioTrib (Horizon 2020, appel à projets 2020)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : SIGNED

The programme of research training will deliver early stage researchers (ESRs) with the necessary technical and innovation training/experience to provide the much needed advances in the performance of both natural and artificial joints with a focus on biotribology, that is, friction, lubrication and wear in these interventions. These researchers will gain the necessary interdisciplinary skills, intersectoral knowledge and the wider innovation abilities demanded by industry with which to deliver timely and cost-effective solutions to some of Europe’s most intractable healthcare problems in arthritis. These aims will be achieved by a unique combination of hands on research in leading research centres, industry secondments and wide-ranging workshops covering technical and transferable skills. Importantly the ESRs will form a network of highly trained innovators and research leaders that are well placed to be employed in Europe's foremost companies and SMEs. The career options for these ESRs are wide ranging including regulatory affairs, commercial R&D, management and policy advisors, as well as academia, all of which comprise a leadership and innovation component. Issues of biotribology are truly a global phenomenon with the deleterious wear related failure of artificial joints running at record levels and predicted to get higher. The highly significant economic and patient issues around early failure in metal-on-metal total hip and resurfacing replacements have been brought sharply into focus, recently. The media have defined this as a significant public health issue and substantial issues persist with very recent reports of inadequate devices. This is a truly European problem with, for instance, new devices manufactured in the UK being first implanted, unsuccessfully, in Belgium, Germany and the Netherlands. Technically BioTrib will deliver new test methodologies, as well as new bearings, for the meaningful assessment of these innovations.

Mots clés : wear, lubrication, friction, debris, artificial joints, joint longevity

Participants :
- Uppsala University (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 1127931.84 €
- Board of the Swiss Federal Institutes of Technology (Suisse) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 1125106.56 €
- Imperial College London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- Luleå University of Technology (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 563965.92 €
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 909517.68 €
Projet 3D-Plant2Cells (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The project 3D-Plant2Cells proposes to explore the impact of the agricultural mode on crops grown for human consumption. We are going to develop innovative interdisciplinary approaches to study the metabolome and the microbiota of plants in three-dimension (3D) at three different scales: the whole plant, the fruit, and the cellular scales. The objective of this study is to get a new insight on the metabolome and microbiota response to pesticide treatment. The hypothesis is that the chemistry and microbiome could change upon the use of conventional cultivation managements. To explore this hypothesis, two groups of plants will be cultivated in growth chamber and one will received pesticide treatments. Then, we will use an innovative interdisplinary approach to explore the entire pool of metabolite (metabolome) and the plant-associated commensal microbes (plant microbiota) on the whole plant surface (plant scale). Samples will be collected on the whole plant and their metabolite content will be profiled by high-resolution tandem-mass spectrometry (HR-MS/MS) and plant-associated micro-organism communities by amplicon sequence analysis. Results of these both inputs will be uploaded into a bioinformatic model representing a 3D topological map of the metabolome/microbiome over the entire organism surface. In a second part of the research project, we will study fruits of the cultivated specimens by 3D mass spectrometry imaging. The goals are to visualize, in a spatially-resolved way, the metabolome/microbiota response to pesticide treatments along with the pesticide distribution in 3D. The metabolome will be investigated at two scales: the fruit and the cell. The fruit scale will be explored by analyzing serial sections using matrix assisted laser desorption ionization (MALDI) or nanodesorption electrospray ionization (nanoDESI) .... The entire project will be an important contribution to assess the impact of pesticide on plant metabolome/microbiome and on food safety.

Mots clés : 3d mass spectrometry imaging, tandem mass spectrometry, molecular networking, microbiomics

Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 246668.4 €