Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ARM4CI (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Hard-of-hearing (HoH) individuals are greatly limited in their interpersonal communications leading them to social isolation and loneliness. To mitigate the communication gap, cochlear implants (CI) were invented to improve speech intelligibility. However, music perception remains severely distorted due to its innate complex acoustical properties. Since music is a ubiquitous means for socio-cultural interactions, the inability to listen to it significantly degrades the quality of life of CI users. ARM4CI aims to enable CI users to perceive and appreciate music holistically through augmented reality (AR). Its objectives include organizing a database containing multimodal data of live music performances, utilizing the database to implement an intelligent system that transforms music that will be more perceivable by CI users, and integrating it into an AR system for evaluation of the quality of experience (QoE) of CI users. ARM4CI has the potential to impact the scientific community by providing a database that enables the development of machine learning algorithms, the CI users by improving their quality of experience in music consumption, and the music industry by introducing a new paradigm of listening to live music through AR. ARM4CI will be implemented in University College Dublin under the supervision of Dr. Andrew Hines. Through this project, a two-way transfer of knowledge is achieved since it combines my experience in multimodal data gathering and analysis of music performances, Dr. Hines' experience in designing algorithms to improve speech intelligibility for HoH individuals, and UCD's capacity to host AR-driven research. The fellowship is a timely opportunity for me to achieve my career goals of securing a tenure faculty position and setting up my own research laboratory for music technology in the future.

Mots clés : cochlear implants

Participants :
- University College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet CMXsafe (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Security in Internet-of-Things (IoT) environments has become a major concern. This is partly due to a large number of remotely exploitable IoT vulnerabilities in service authentication and access control combined with the lack of timely technical support. Furthermore, emerging regulations require changes in IoT deployments difficult to apply in a generalisable fashion. This difficults reusability, and scalability, and increases development and management costs. Therefore, the objectives of CMXsafe are twofold: a) Provide a proxy-layer communication architecture devised to offload security communications functions from IoT applications into application-agnostic proxy modules. This simplifies IoT device application designs and the deployment of security updates. b) Devise CMXsafe components abiding by the Security Evaluation Standard for IoT Platforms (SESIP) methodology, accepted by the European Committee for Standardization to facilitate composite cybersecurity certification schemes. To accomplish this, I will describe the technical requirements according to the SESIP standard and implement a testbed comprising 8 IoT devices and the cloud side of CMXsafe architecture. These activities will take place at the University College of Dublin School of Science, at the ASEADOS Lab where I will be supervised by Prof. Anca Delia Jurcut. CMXsafe will allow me to improve my competencies in cybersecurity regulations, cloud architectures and valuable transferable skills required to succeed in the industry. CMXsafe will guarantee a successful two-way transfer of knowledge because CMXsafe combines my background experience in security decoupled communications with the host’s experience in cybersecurity, regulations and business relations with industry partners. Therefore, CMXsafe will contribute with an IoT proxy-based communication architecture that facilitates security updates and regulation compliance.

Mots clés : communication architecture, proxy layer, security decoupling

Participants :
- University College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet PopText (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This interdisciplinary project embarks on an extensive exploration of the methodologies that underlie the study of populism through textual analysis, with the primary goal of enhancing our comprehension of this intricate phenomenon. The surge of populism on the global stage underscores an urgent need for scholarly investigation. However, the nuanced and adaptable nature of populism presents challenges, complicating efforts to establish a single, universally accepted definition. This conceptual ambiguity not only fuels ongoing debates about the core essence of populism but also permeates empirical analyses, including those centered on textual investigations. Despite the growing body of theoretical and empirical work, a noticeable gap persists in our grasp of the methodological subtleties inherent in the analysis of populism through texts. These methodological intricacies encompass a spectrum of dimensions, ranging from the application of conceptual frameworks to textual analyses, to the adaptation of text-as-data techniques capable of capturing the dynamic evolution of populism over time. This groundbreaking project marks an unprecedented endeavor in conducting cross-national and longitudinal evaluations of political parties' populist discourse. It employs a robust methodology integrating manual coding and machine learning techniques. By engaging with theoretical concepts and deploying cutting-edge AI tools to generate unique datasets capturing populism in texts, this project stands poised to enrich our nuanced understanding of how populism is conveyed across diverse temporal and contextual dimensions, pushing the boundaries of current knowledge in the field.

Mots clés : populism, party behaviour, text as data, computational text analysis, comparative politics

Participants :
- University College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet HASPS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Per- and polyfluoroalkyl substances (PFAS) threats to human health as “forever chemicals” and a key issue addressed by the European Commission. Urban sludge in wastewater treatment plants has become a sink from PFAS, the final “end of the pipe”. However, the accumulation process of PFAS in urban sludge and the intricate interplay between PFAS and sludge components are still unknown. Here, the HASPS project aims to comprehensively investigate the binding of PFAS with various structural features to individual EPS components such as proteins, polysaccharides, humic acids, and nucleic acids, a task previously unexplored. To achieve this, we will comprehensively characterize the EPS present in sludge samples from different countries, such as Denmark and Singapore, and its importance on PFAS adsorption in sludge. A new extraction method for each EPS component will be established through a combination of physical and chemical treatments. Further, we will unveil the interaction mechanism between each EPS component and PFAS with diffident chains and functional groups using extracted EPS and model EPS components. A novel adsorption mechanism approach will be established based on spectroscopy, mass spectrometry, surfactant techniques, and computational models. This new knowledge of exploring PFAS accumulated in sludge is essential for implementing effective pollution control strategies to minimize the entry of PFAS into the environment. With this project, I am aiming to combine my background in organic pollutant control with the distinguished expertise of the host research group focusing on PFAS and EPS in sludge at Aarhus University.

Mots clés : per and polyfluoroalkyl substances pfas , urban sludge, extracellular polymeric substances eps , interaction mechanism

Participants :
- Université de technologie de Nanyang (Singapour) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet GALENE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The study of material culture is one of the main tools for the past societies’ knowledge. Recently, new techniques, protocols and disciplines applied to traditional archaeological methodology have proved that glass played an important role in economic and social development through history. Regard to the Iberian Peninsula, works on archaeological glasses has focused on purely typological issues, above all from the Roman times, leaving aside other later historical periods. As part of our cultural heritage, the study of glass in al-Andalus can help to understand aspects and practices of Andalusian societies. For this reason, the project ‘Glass, alchemy and medicine. Evidences of domestic practices in the capital of the Andalusian Caliphate’ (GALENE) is proposed, which main objective is to establish the classification of glass for cosmetic and medicinal uses in domestic contexts of this period. This project proposes the study of an important set of glasses from Cordoba (Spain) by combining different skills and multidisciplinary approaches (traditional studies, experimental archaeology and the chemical analysis of materials) to determine for the first time the importance of glass in alchemy and medicine in Medieval times, the origin and manufacture of these vessels and objects, their evolution and whom used them, with especial attention to the female gender. GALENE will be conducted by Dr Velo at the Glass and Ceramics for the Arts (VICARTE) research unit of the Universidade Nova de Lisboa (Portugal), under the supervision of Prof Vilarigues. VICARTE is a research group of international relevance that combines different areas for the study of glass in antiquity and in the plastic arts. This centre has the facilities and technology necessary for the development of this project that will reinforce the protection of our cultural heritage and contribute to the integrity of the cultural diversity of today’s society, which is the result of our past and history.

Mots clés : andalusi glass, islamic culture, ancient glass, islamic medicine, islamic alchemy

Participants :
- Université nouvelle de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172618.56 €
Projet FIAT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Mitochondrial morphology is controlled by a set of “mitochondria-shaping” proteins that govern fusion and fission of the organelle. Fission is executed by dynamin-related protein 1 (DRP1) that binds to adaptors on the outer mitochondrial membrane to oligomerize and sever mitochondria. Fission 1 (FIS1) is among the putative mammalian DRP1 adaptors, but it appears dispensable for mitochondrial fission. Conversely, FIS1 seems to participate in the regulation of mitochondrial autophagy (mitophagy), interaction between mitochondria and lysosomes, and apoptosis. Because of these multifunctional roles, FIS1 emerged as an appealing pharmacological target and peptides inhibiting its interaction with DRP1 have been advanced in the experimental treatment of ischemia-reperfusion and of genetic conditions such as Huntington’s disease. More recently, FIS1 was identified as a crucial factor to sustain Leukemia Stem Cells (LSCs) in Acute myeloid leukemia (AML), the second most prevalent and the most fatal leukemia in adult patients. However, our scarce knowledge of the biology of Fis1 is mirrored by the uncertainties on how FIS1 regulates AML LSCs. To close this gap in knowledge, I will take a chemical biology approach and design innovative genetically encoded sensors for FIS1 functions that I will use to identify potential FIS1 small molecules inhibitors. I will then use these chemical probes to evaluate which cellular function of FIS1 is essential for maintenance of AML LSCs. Overall, this project will unveil how a multipronged mitochondrial protein regulates cell pathophysiology and will deliver novel chemical tools to investigate FIS1 function in the context of AML and potentially to evolve into therapies for this hitherto poorly treatable cancer.

Mots clés : mitochondria, dynamics, fission, acute myeloid leukemia, in silico drug screening

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet HAPTEXT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The project, HAPTEXT, examines how periodicals - texts printed at routine intervals - circulated to create the first age of 'viral' media in the eighteenth century. Within the anglophone world, periodicals have long been recognised as a vital source of information on political, social and economic matters in a period heralded as the Age of Enlightenment. Yet periodicals are yet to be fully integrated into cultural studies of the eighteenth century and there has been no systematic study of how information circulated across titles to reach wider audiences, or how readers actively responded to public papers by annotating the printed page or writing letters for publication. The project objectives are to:  1. Establish a new methodology for periodical studies that reveals how individual readers interacted with periodicals 2. Demonstrate how content escaped the control of its authors, being remediated and transmediated to reach new audiences 3. Reveal how radical ideas circulated between publications and between readers via the periodical 4. Build the first bibliographic database dedicated to locating periodical publications  Using close textual analysis, computational history and corpus linguistics, HAPTEXT reveals how interactions with and upon the printed page intersected with literary endeavour to produce ‘viral’ media. The anglophone context provides a rich cache of material for study, revealing the changing priorities and anxieties of an island nation in an increased age of globalisation and period of colonial wars (American and French Revolution, Napoleonic War).  Through this Fellowship, the researcher, Dr Jennifer Buckley, will develop the training, high-impact dissemination, and experience commensurate with a leading researcher of her career stage. The researcher will be based in the School of Critical Studies, University of Glasgow, and supervised by Prof. Matthew Sangster, a leading expert in Book History, authorship and Digital Humanities.

Mots clés : eighteenth century studies book history digital humanities material culture

Participants :
- Université de Glasgow (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet PLURImet (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The naïve inner cell mass of the human embryo is characterized by unlimited developmental plasticity as it gives rise to all somatic and extraembryonic lineages. Following implantation, extraembryonic and auto inductive signals prime pluripotent cells for differentiation toward the three germ layers. Concomitantly, metabolic gene expression transits from oxidative phosphorylation towards a glycolytic metabolism. This developmental progression can be recapitulated in vitro using human pluripotent stem cells (hPSCs), a prominent tool for basic and translational research with a great impact on health and economics. Ligands of the JAK/STAT pathway are routinely used for the expansion, generation, and differentiation of naïve hPSCs. In rodents, JAK/STAT signaling controls both pluripotency gene expression and metabolism, but its role in human pluripotency is still unclear. In this project, I will unravel the contribution JAK/STAT pathway to both the transcriptional program and metabolism of human naïve pluripotency. I will study the role of metabolism during the generation, expansion, and differentiation of naïve hPSCs. Moreover, I will produce the first comprehensive computational model of hPSC metabolism to identify metabolic changes associated with human pluripotency transitions. This study is highly interdisciplinary, including scientific expertise encompassing cellular and molecular biology, biophysics, high throughput technologies, and computational biology. The wide scientific and transferable skills training provided by the host institution will allow me to achieve personal and professional maturity, crucial for an independent and competitive scientific career in Europe. The variety of the dissemination and communication measures implemented will definitively ensure maximal reachability to the project, maximizing the scientific and social return of this research.

Mots clés : naive pluripotency, jak stat pathway, proliferation, differentiation, oxidative phosphorylation, glycolysis, mitochondria, transcriptomics, metabolomics, in silico modeling

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172750.08 €
Projet ChirAzaL (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The aim of ChirAzaL is to devise innovative and sustainable technologies in organic synthesis to access general, modular, and scalable crafting of two families of biologically relevant chiral nitrogen-containing molecules, namely: azetidines and multisubstituted linear amines. Such molecules are characterized by a complex three-dimensional arrangement and a high degree of saturation. Harnessing visible-light as sustainable and unexpensive source of energy, I will use a strain-release approach to access these synthetically complex scaffolds. Asymmetric phase transfer catalysis and chiral-metal templated catalysis will be the foundation of this proposal for securing stereocontrol. In order to accomplish the overarching goal of the research program, it will be divided into two main stages: an exploratory Stage I, followed by the consequently more applicative Stage II. The application of the developed photocatalyzed transformations in flow technology will unlock a new and operational-friendly pathway to azetidines and multisubstituted linear amines under mild and efficient conditions. Lastly, the implementation of the developed chemistry, as a functionalization tool, will give access to a straightforward methodology which has serious potential to be embraced on any synthetic route. The multidisciplinary skills acquired due to the interaction between the two phases, together with the transfer of knowledge between me and the hosting group will guarantee the successful realization of ChirAzaL.

Mots clés : chirality, nitrogen, heterocycle, strain, drug discovery

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet PhotoClean (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Increasing energy consumption, depletion of natural resources, and environmental pollution are nowadays among the biggest economic and social challenges. Per- and polyfluoroalkyl substances (PFAS), also known as forever chemicals, are persistent emerging pollutants not naturally degraded in the environment. PFAS are anthropogenic compounds with harmful health effects, inert and resistant to heat, and nowadays found in water, air, and soil, thus posing a heavy impact on our environment. Adsorption on activated carbon, ion-exchange resins, cyclodextrins, and nanofiltration are the methods currently used or under study for PFAS removal from water. However, critical gaps, such as the adsorbent regeneration, affinity, production of secondary waste, analytical method limitations, and efficient PFAS degradation pathways are major challenges. PhotoClean aims to synthesize novel palladium functionalized, solvent-responsive nanocage adsorbents able to remove PFAS from water. The nanocages will promote rapid PFAS photodegradation, being excited by visible-light to a photoexcited state able to interact with PFAS through a single electron transfer. Depending on the energy of the photoexcited state, PFAS decomposition is expected to be initiated either through oxidative or reductive events and be sustained by the formation of radicals. The new approach proposed by PhotoClean is based on the development of reusable adsorbent cages and the exploitation of visible-light as the energy source to activate PFAS decomposition; it thus constitutes an environmentally sustainable strategy for PFAS removal and degradation. The project will contribute to understand fundamental structure-property relationships of PFAS adsorption on nanoporous organic cages and integrate photodegradation of PFAS with catalytic activity. The action has the potential to revolutionize methods for PFAS removal from water and tackles a variety of scientific and societal challenges of environmental importance.

Mots clés : per and polyfluoroalkyl substances, porous organic cages, water pollution, adsorption kinetics, adsorption isotherms, photocatalysis, photodegradation, decomposition

Participants :
- Université de Padoue (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €