Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet PIA (Horizon Europe, appel à projets 2023)
Action : Doctoral Networks - Industrial Doctorates
Panel : Chemistry
Statut du projet : SIGNED

The European Union has been challenged to contribute to the global aim of providing sustainable solutions to the current and future needs on synthetic compounds and materials in the coming years. In this sense, the development of sustainable chemical processes is one of the most important features in modern chemistry. It has become a key research area worldwide, providing solutions to important societal demands by optimizing the use of natural resources and minimizing waste and environmental impact. Among the relevant methods for achieving this goal, catalysis represents a key and central approach. Both Organocatalysis and Metal Catalysis have emerged as solutions to the problems in this context. Despite the enormous advances made towards both types of catalysis, the development of more efficient and general catalysts, as well as synthetic methods is still a challenge. A very similar research-road has occurred in the Photocatalysis area, using visible-light as mild and sustainable energy source.  In this context, the pharmaceutical industry has a great impact in our society. Well-stablished organo- and, especially, metal-catalysis have been largely implemented in the chemical industry, both on a micro and ton scale. However, there are only few timid academic applications of novel photocatalytic visible light methodologies into industrial goals. Therefore, the development of cheaper and straightforward methodologies to the incorporation of key photochemical processes is an important field and has a tremendous impact in the industry field. Therefore, greater blending of academia and industry would be desirable for the implementation of photocatalysis in the chemical industry world. Students who can access this doctoral network will have the opportunity to work in European Funded academic researchers and in three Big Pharma companies in a hot field such as photocatalysis with the aim to develop new real industrial solutions.

Mots clés : photocatalysis, pharmaceuticals, synthesis

Participants :
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 282693.6 €
- Pcas (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 282693.6 €
- Université Paris-Saclay (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Sanofi (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €
- Université de Münster (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 260539.2 €
- Synthelia organics sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 251971.2 €
- Université autonome de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 251971.2 €
Projet SCION (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : SIGNED

To satisfy the expected plethora of demanding services, 6G is envisioned as a revolutionary paradigm to carry forward the capacities of enhanced broadband, massive access, and Ultra-reliable and low latency services in 5G wireless networks to a more robust and intelligent level. This move will introduce significant new multidisciplinary research challenges emerging throughout the wireless communication protocol stacks, including the way the mobile network is modelled and deployed. The structure of 6G networks will be highly heterogeneous, densely deployed, and dynamic. Combined with the tight quality of services, such complex architecture will result in the untenability of legacy network operation routines. In response, artificial intelligence (AI), especially machine learning (ML), Semantic Communication and Digital Twin (DT) are emerging as solutions to realize the fully intelligent network orchestration and management. By learning from uncertain and dynamic environments, AI-enabled channel estimation and spectrum management will open up opportunities for bringing the excellent performance of Ultra-broadband techniques into full play. Additionally, challenges brought by Ultra-massive access concerning energy and security can be mitigated by applying AI-based approaches.  The overall research objective of the SCION project is to develop and design the network systems for seamless wireless access for Secure and Intelligent Massive Machine-to-Machine Communications for 6G. In addition to technology development, to meet the urgent needs for the future working force of the coming 6G era, this collaborative project will create a training network for Doctoral Candidates who will contribute to the design and implementation of future 6G networks.

Mots clés : 6g, digital twin, blockchain, semantic communication, power splitting

Participants :
- Huawei Technologies (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €
- Université de technologie d'Eindhoven (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274370.4 €
- Université de Nottingham Trent (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- KTH Institut royal de technologie (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 587419.2 €
- Université de l'Essex (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Iris automation ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut de haute-technologie d’Izmir (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 219168.0 €
- Université d'Aveiro (Portugal) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Data machine elite, lda. (Portugal) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 486806.4 €
Projet QUARC (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : SIGNED

Quantum Computers are about to be accessible to the public. The ability for Quantum Computers to break classic cryptography protocols is pushing the adoption of Post-Quantum Cryptography (PQC). PQC protocols are resistant against quantum computers. During 2022, and after several years of research, the first standards on PQC will be made available to the public. Although the EU has some scattered activities on PQC, it has not yet addressed the need for PQC experts in application of this emerging technology. This is the driving force for QUARC, a Doctoral Network Industrial Doctorate on PQC, providing interdisciplinary and integral training and research in PQC. QUARC will train 8 Doctoral Candidates (DCs) through an outstanding training program that includes coordinated research in different cryptography areas, focusing on implementation. QUARC is an industrial doctorate, and besides a 50% of their time located in an industrial partner, each DC will be also exposed to a set of training initiatives in the areas of relevance for industry and receive the support of an external advisory board made out of experts in the field. QUARC establishes a well-balances, interdisciplinary, intersectoral and innovative training network, with an overarching theme of quality and edginess: research as a training tool to push the current state-of-the-art in PQC.

Mots clés : post quantum cryptography

Participants :
- Nvidia (United States) (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 259437.6 €
- Université d'Aalborg (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 301788.0 €
- Nvidia denmark aps (Danemark) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 301788.0 €
- Université complutense de Madrid (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de technologie d'Eindhoven (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 617333.4 €
- Mellanox Technologies (Israel) (Israël) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 475007.4 €
- Nvidia (United States) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €
Projet MULTICELLEXPEVO (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

All living animals are descended from a single-celled ancestor. Understanding how this ancestor became the first multicellular animal remains a major challenge in the field of evolutionary biology. Phylogenomic analyses have shown that animals are closely related to three unicellular lineages: choanoflagellates, filastereans and ichthyosporeans, altogether forming the Holozoa clade. Genetic and phenotypic studies have shown that the filasterean Capsaspora owczarzaki can under specific growth conditions form transient multicellular aggregates. However, why is this multicellularity only transient? What are the genetic and phenotypic requirements for its emergence and stabilization? And what is the role of the actin cytoskeleton in this transition? Indeed the actin cytoskeleton is known for its pivotal role for cell coordination and morphology, which must play a role in evolution of multicellularity. To address these questions, we will use the C. owczarzaki as a model organism. We will combine cell biology, genomics and experimental evolution to unravel multicellularity emergence and stabilization. Specifically, we will aim to obtain evolved mutants showing excessive and more stable multicellular behaviour of C. owczarzaki using long-term experimental evolution. Such evolved strains would unravel how multicellularity emerged and stabilized. In addition, using random mutagenesis screen, we aim to identify mutants unable to form multicellular aggregates. Such mutants would reveal the minimum genetic requirements for such a transition. Finally, we will take advantage of recently developed genetic tools in C. owczarzaki to study the actin cytoskeleton during the cell cycle. Our results could reveal how the first multicellular ancestor of animals appeared from a genetic and cellular perspective, and, how cell fate specification was established during evolution. Results generated on this fellowship will be relevant to evolutionary, cell and developmental biologists.

Mots clés : multicellularity emergence, metazoa, actin organization, experimental evolution

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €
Projet HG-Emo (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Although human emotions have a common biological basis, different cultures elaborate different aspects of their emotional world. This variation is reflected in the emotion lexicon, which, despite being well-studied among industrialized societies, remains under-researched in smaller cultural niches. This project focuses on emotion among hunter-gatherers, a rare type of society today, but a dominant one for 95% of human existence. Hosted by the UCL Anthropology Department—a world leader in hunter-gatherer studies—I will investigate the emotion lexicon in two hunter-gatherer languages to uncover the relationship between the semantic domain of emotion and sociocultural characteristics associated with different settlement patterns (mobile vs. sedentary), e.g., group size and social structure. Using methods from linguistics, psycholinguistics, and cultural anthropology, I will document the emotion lexicon among the closely related mobile Maniq and the sedentary Kentaq (Aslian, Austroasiatic) and examine it against the sociocultural background of each group. Via systematic comparison, I will identify forces shaping the emotion lexicon in each language, ultimately revealing how emotion language may coevolve with sociocultural change triggered by sedentarization. The findings will speak to the fundamental question of how meaning is shaped in our languages and will be of value to semantic typology, hunter-gatherer studies, and psychology.

Mots clés : semantic typology, emotion lexicon, hunter gatherer, residential mobility, aslian languages

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet Learn2 (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Although sport is habitually promoted as an important context for positive youth development and learning, there is a lack of understanding of what learning in sport is and how it shapes and is shaped by the learner’s identity, values, and socio-cultural situatedness. Using an existential-phenomenological approach, we theorise and explore student-athletes’ learning experiences in sport, providing knowledge that is radically innovative and helps to validate experiential learning in sport. The study responds to European Union initiatives to safeguard the development of talented youth athletes and validation of informal and non-formal learning. Eighteen Finnish student-athletes (10 women) aged 18-19 will participate in hermeneutic interviews focused on clarifying meaning in their learning experiences in sport. Drawing on Structural Existential Analysis, we seek to uncover the essential – yet always situated – structures of athletes’ learning experiences. We also explore gender dimension of learning and sporting experiences. Based on the findings, we will propose a framework for further research and provide recommendations for policy and practice. The findings will be valuable for educational institutions and dual career service providers, as well as sport coaches and student-athletes to support athletes’ future employability and transition into the labour market. The existential-phenomenological perspective offers a novel methodological approach and our study involves a truly interdisciplinary research team (developmental and cultural psychology, existential philosophy, and phenomenological sociology). The project offers training for the experienced researcher in research and transferable skills as well as gender issues, and knowledge transfer through secondment, research visits, and seminars. The project provides the experienced researcher with the possibility to reinforce a position of professional maturity and become a research leader in the subject area.

Mots clés : informal learning, youth sport, dual career in sport and education, career development and transitions

Participants :
- University of Jyväskylä (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 179325.6 €
Projet CTS-TEs-ADprogress (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Alzheimer’s disease (AD) is a major contributor to disease burden and healthcare costs worldwide. AD is usually diagnosed once symptoms like memory impairment become evident. However, at this point typical AD pathology such as Aβ plaques and cell death is already widespread, suggesting that molecular changes have occurred decades before symptom onset. With an increasingly aging population and no available treatments, it has become imperative to identify the molecular mechanisms underlying onset and progression of AD. Chronic environmental stress and age-associated changes in stress response have been associated as drivers of AD pathology. The epigenome plays a critical role in translating stress signals into a cellular response by influencing gene expression, which can either promote or inhibit cell survival. Several studies have shown that alterations in chromatin structure, including heterochromatin loss, and associated changes in gene expression contribute to neurodegeneration. In addition, neuronal death was also linked to transposable element (TE) dysregulation due to epigenetic changes, which can lead to changes in gene expression and insertional mutations due to transposition. However, our understanding of epigenetic changes at onset and during progression of AD pathology is very limited, as current studies have two major limitations: 1) lack of cell type resolution due to use of bulk tissue samples and 2) coverage of only few or only one disease stage. Here, single-cell RNA-seq and ATAC-seq as well as CUT&RUN on isolated hippocampal neuron subtypes will be used to identify cell type-specific alterations of gene expression and gene regulatory mechanisms during onset and progression of AD pathology in the APP/PS1 mouse model. APP/PS1 mice are a well-established AD model, which recapitulates many characteristics of preclinical AD in human patients and thereby allows correlating the identified changes with the development of specific pathological hallmarks.

Mots clés : single cell, disease onset and progression, gene regulatory changes, transposable elements, multi omics data integration, longitudinal analysis

Participants :
- German Center for Neurodegenerative Diseases (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 174806.4 €
Projet TRACE-AD (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Alzheimer’s disease (AD) is a tremendous burden and there are still no therapies available. Most clinical trials have focused on the late disease stages where neuronal damage is already severe and irreversible. To intervene in earlier stages, it is essential to understand how AD pathology affects brain systems early in the disease. Beyond that, we need better markers to identify individuals at an early asymptomatic stage that will likely deteriorate in the coming years as well as measures of treatment response to assess the benefit of a treatment. I focus on two functional brain systems that are critical for memory in humans and are very early affected by AD pathology. With the powerful and novel combination of positron-emission-tomography and ultrahigh-field magnetic resonance imaging, I will unravel the early effects of AD pathology on brain connectivity and activity, grey matter loss and memory function within both brain systems. I will use a pseudo-longitudinal design to study changes in brain system integrity and memory during disease progression in the very early stages of AD. To identify predictive markers of progression, I will use monthly repeated smartphone-based assessments throughout one year to i) define cognitive trajectories of individual memory decline, ii) characterize stage-specific decline rates, and ii) determine the best cognitive and imaging markers for prediction of cognitive decline. Taken together, this proposal will result in a more profound understanding of the earliest stages of AD and provide novel markers that will improve patient selection as well as assessment of treatment response in future clinical AD trials. This will advance the development of new disease-modifying therapies and early clinical diagnosis. Importantly, realizing this proposal will provide critical training of scientific and transferable skills that are required to follow my research interests and to set up my own research group in the future.

Mots clés : early alzheimer s disease, tau and amyloid pet imaging, ultrahigh field mri at 7t, mobile cognitive assessments, human object and scene memory, medial temporal lobe, hippocampus, entorhinal cortex

Participants :
- Lund University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191852.16 €
Projet iMIND (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Alzheimer’s disease (AD) is an irreversible neurodegenerative condition affecting 50 million people worldwide. To date, no disease modifying therapy for AD is available. Neuroinflammation is emerging as an important component of the disease. A recent GWAS analysis identified a rare protective coding mutation (P522A) in the PLCG2 (Phospholipase C Gamma 2) gene that is associated with AD. Interestingly, the gene encodes a transmembrane signaling enzyme that is highly enriched in microglia. The major aim of the proposal revolves around the functional characterization of the P522A mutation in microglia. To that aim, using an array of biochemical, imaging, functional, and transcriptomic assays, we will investigate human microglia generated from control- and AD patient-derived induced pluripotent stem cells (iPSCs). iPSCs will be gene-edited to generate P522A mutated isogenic cell lines. The proposal aims at identifying novel therapeutic targets and, in line with the objectives of the H2020 Framework Programme, explores new grounds in the molecular underpinnings of AD. The use of cutting-edge and innovative approaches (CRISPR/Cas9 gene editing, iPSC reprogramming, RNA-Seq analysis, high-throughput screening, and subcellular calcium imaging) provides a novel experimental model that is closer to the pathological processes of the AD brain and bypasses the limitations and shortcomings of preclinical AD animal models.

Mots clés : ipsc, alzheimer s disease, gene editing, crispr, cas9, rna seq, mitochondria, endoplasmic reticulum, calcium signaling, bioenergetics, plcg2, inflammation

Participants :
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Chieti-Pescara (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 269002.56 €
Projet UbiGolD (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Alzheimer’s disease (AD) is the most common neurodegenerative disorder which affects 47 million patients worldwide. However, the underlying molecular mechanisms leading to sporadic-AD remain unknown and preventive treatment is not yet available. Lately, the ubiquitin-proteasome system has been implicated in AD. Dr. Merbl’s laboratory recently discovered a novel mechanism of Golgi-localized proteasomal degradation that controls Golgi integrity under stress. As the Golgi apparatus is the major hub required for protein secretion and plasma membrane localization, its proper function is crucial for maintaining cellular homeostasis and controlled cell-cell communication. This intriguing finding may be of instrumental importance to evidence of Golgi fragmentation which is observed in neurons in neurodegeneration diseases including AD as the Merbl lab identified that the ubiquitin-proteasome system is required for Golgi fragmentation. My goal is to identify regulatory mechanisms of ubiquitin E3 ligases that are involved in Golgi fragmentation in neurons. Specifically, I aim to identify critical determinants that regulate Golgi homeostasis and integrity under changing pH and calcium concentration and decipher their role in AD using CRISPR gene manipulation, pH-dependent immunofluorescence and biochemical methods and state-of-the-art proteomic and glycomic techniques. Elucidating ubiquitin-dependent regulation of Golgi fragmentation in neurodegeneration and AD would advance our understanding not only of Golgi biology and provide new possibilities for therapeutic intervention for neurodegeneration.

Mots clés : protein degradation, golgi homeostasis, e3 ubiquitin ligase

Participants :
- Weizmann Institute of Science (Israël) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185464.32 €