Projet GLYCO-N (Horizon Europe, appel à projets 2022)
Action : Doctoral Networks
Panel : Chemistry
Statut du projet : SIGNED

The GLYCO-N training network aims at training Doctoral Candidates (DCs) to acquire the skills to develop different innovative strategies to 1) understand the diversity and structural complexity of archaeal, microalgal and viral N-glycosylation and 2) harness this knowledge for new solutions in biomedicine and biotechnology. Protein N-glycosylation, or the attachment of oligo- and polysaccharides at specific asparagine residues, is conserved throughout life, and is now observed even in the viral world. In contrast to eukaryotes, whose well-studied N-glycosylation machineries are relatively simple, archaea, microalgae and bacteria utilize a wide variety of monosaccharides to create a wealth of structurally diverse N-glycans, and the same holds true for some recently discovered viruses. Because protein glycosylation occurs far downstream of protein synthesis the complexity and diversity in N-glycan structures are poorly understood in detail. This holds true specifically for N-glycosylation events that are the subject of the GLYCO-N program: those in archaea, microalgae and viruses. Understanding of the how and why of N-glycosylation in archaea, microalgae and viruses will open up many possibilities ranging from drug discovery (antivirals) to biotechnology (glycoprotein and glycoprocessing enzyme engineering for materials and life sciences). The GLYCO-N network brings together a diverse group of glycobiology researchers with world-leading expertise in microbiology, (bio)organic chemistry, computational and structural biology, bioinformatics and chemical biology. The GLYCO-N DCs will have their own individual project with one GLYCO-N expert and will, through research internships, be exposed to complementary Glycoscience. All individual PhD projects, while rooted in fundamental science, have a practical application, either in biotechnology or in biomedicine, as will be explored through secondments with our associated partners.

Mots clés : n glycans glycoengineering carbohydrate processing enzymes biomedicine biotechnology

Participants :
- Atlas molecular pharma sl (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université technique du Danemark (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 301788.0 €
- Université technologique de Dresde (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université du Pays basque (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Innovation acta srl (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Leyde (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 548740.8 €
- Alga biologics (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Isuschem s.r.l. (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Samabriva (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Center for Cooperative Research in Biosciences (Espagne) — Partner, beneficiary, Recherche, subvention : 251971.2 €
- Institut Francis Crick (Royaume-Uni) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Barcelone (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 251971.2 €
- Université de Naples - Frédéric-II (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 518875.2 €
- Université de Duisbourg et Essen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 521078.4 €
- Adaptam therapeutics sl (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Imperial College London (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Rouen Normandie (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 282693.6 €