Projet BestTreat (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

BestTreat fosters education of ESRs in a project to uncover microbiome signatures for risk prediction and monitoring of NAFLD and to contribute to the development of therapeutic treatments based on metabolically beneficial microbial consortia. It trains 15 ESRs at world-leading academic institutions and companies, thus forming strong interdisciplinary links between industry, life and medical sciences, and end-users. BestTreat aims to train a new generation of highly qualified ESRs with entrepreneurial competencies in modern Life Sciences through state-of-the-art research projects. The projects focus on the identification and functional characterization of microbial consortia that contribute to metabolic control, and the application of this knowledge to develop novel leads for drug discovery and therapies for NAFLD. The new field on microbiome based therapeutics requires highly skilled scientists with interdisciplinary knowledge on medicine, systems biology and computer science, as well as hands-on experience with several types of tissue samples and model organisms that can optimally translate their research findings into sustainable improvements in clinical practice. BestTreat overcomes current barriers by establishing a strong, multidisciplinary and inter-sectoral training network, developing technologies tailored to solve key questions in human metabolism, microbiology and bioinformatics. The BestTreat programme will exploit recent developments in high-throughput and genome-wide screening technologies, combine these with modern molecular cell biology and systems biology approaches and ultimately translate the data into new leads for the discovery of live biotherapeutics. This specific cross-disciplinary training program will educate young scientists to the next level needed to advance this research field for the upcoming decennium. The training programme will be complemented with a complete set of transferable skills.

Mots clés : gut microbiome, bio engineering, metabolomics, metagenomics, metatranscriptomics, cytokines, obesity

Participants :
- Shanghai Sixth People's Hospital (Chine) — Partner, organization partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Udatha dasaradhi (Suède) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Bravad production aps (Danemark) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Friedrich Schiller University Jena (Allemagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Technical University of Denmark (Danemark) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 595044.0 €
- Afekta technologies ltd (Finlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 280805.76 €
- University of Groningen (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 531239.76 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 531239.76 €
- Chr. Hansen (Denmark) (Danemark) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 297522.0 €
- Gubra aps (Danemark) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Leibniz Association (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 758365.2 €
- University of Eastern Finland (Finlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 842417.28 €
- Biofaction (Austria) (Autriche) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Clinical Microbiomics (Denmark) (Danemark) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 297522.0 €