Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MONONANOCHEM (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The success of current antitumoural therapies largely depends on the availability of appropriate drug delivery strategies, which have to allow the penetration of these drugs through the tumoural microenvironment. The knowledge related to the cellular heterogeneity of the tumours has advanced enormously in the last years. Tumour associated macrophages (TAM) can represent up to 50% of the tumour mass. TAM are derived from circulating monocytes, which are recruited from the peripheral blood towards the tumour in response to a broad range of molecular signals (i.e. cytokines). Recently several studies are focused on the development of therapeutic strategies targeting TAM, however, the possibility to use monocytes, with excellent ability to infiltrate the abnormal tumoural tissue, to deliver chemotherapeutic drugs into the tumour has been hardly explored. Here, we aim to use the host monocyte/macrophage cells, with high ability to infiltrate the tumoural tissues, to deliver nano-chemotherapeutic formulations into the bulk of the tumour. We will develop Nano-Formulations consisting in Hyaluronic Acid (HA) nanostructures decorated with beta-glucans, allowing the targeting of specific receptors on the host circulating monocytes (Dectin-1), and at the same time, the loading of chemotherapeutic drugs into these cells. Cytotoxic drugs inducing immunogenic cell death (i.e. bortezomib), and thus the recruitment of new monocytes, will be used to enhance the efficacy of the therapy. Overall, we will use Monocytes loaded with Nano-ChemoTherapeutic Formulations (MNCTFs) as a new strategy to deliver cytotoxic drugs towards the tumoural cells, taking advantage of the infiltration ability of the monocytes/macrophages into tumour microenvironment. The MNCTFs will be tested using appropriate in vitro 2D and 3D tumour models and in vivo murine tumour models. We expect that this new live-cell mediated drug delivery system will provide greater progress in the treatment of cancer.

Mots clés : cancer immunotherapy, monocyte, macrophages, nanomedicine, live cell mediated drug delivery

Participants :
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 168277.2 €
Projet GuEst (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The technique of guaranteed estimation promises a revolutionary step to how industrial process managers build, handle and adapt the prediction mathematical models. These are used to monitor the equipment operating regimes, to train the operating personnel and are also exploited to steer the plants' behavior towards the most profitable or the most resource- efficient modes. Advantages of guaranteed estimation come from the fact that no unnecessary assumptions must be made regarding the quality and measurement-error distribution of the sensed data, which establishes an increased reliability of the obtained estimation results. The work on this project develops the essential parts of guaranteed estimation techniques for real-world exploitation. We focus on the estimation of parameters of the nonlinear dynamic models while combining the estimation with model validation principles and while creating a hybrid estimation technique that enjoys the advantages of both guaranteed estimation and conventional approaches. In order to drive the operation of the plant, here we focus on the plants of chemical industry, to an efficient working regime, the technology of optimal and robust control is required. Our project builds upon the developments of robust control and develops novel optimal robust control techniques that incorporate the information on guaranteed estimates into the actions, i.e. manipulations of the plants' degrees of freedom. As a result, a safe, reliable and resource-efficient operation is established. The theoretical developments of the project are implemented into a software package and released as an open-source project such that the collaboration with academia and industrial stakeholders is fostered. A demonstration on a pilot plant is also planned to showcase the benefits of developed techniques in the real-world environment. A sound dissemination plan of the project ensures that the project reaches its target audience.

Mots clés : identification of nonlinear systems, parameter and state estimation, set membership estimation, optimal control, robust control, chemical process control

Participants :
- Slovak University of Technology in Bratislava (Slovaquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 141381.6 €
Projet Self-EsteemProcesses (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The transition into the workforce is a major developmental milestone in young adulthood that brings tremendous life changes and sets the course for future development. This project aims to examine the impact of the work transition on self-esteem, a key personality characteristic responsive to experiences of success and failure. Self-esteem is among the strongest predictors of major life outcomes, including mental and physical health, economic prospects and longevity. Long considered to be highly stable across the lifespan, new evidence shows that self-esteem can change in response to life events. Yet, knowledge about the processes that elicit change is scarce as research relies on few assessments and theories mute on mechanisms. The central aim of this project is to advance the understanding of the mechanisms underlying self-esteem change by closely dissecting the macro- and micro-level processes. I have developed a framework that integrates different theoretical approaches to understand self-esteem processes. It has three aims: (1) To study the macro-level contextual changes, (2) To examine the micro-level processes of thoughts, feelings, and behavior evoked through the individuals’ daily interaction with the environment and (3) to examine how the resulting changes in state self-esteem (short-term changes) get manifested in trait self-esteem (long-term changes). A comprehensive multi-method approach will be used that combines high-density in-situ assessments of daily life using a novel smartphone technology and physiological assessments (to illuminate the short-term processes) with multi-wave self- and observer-reports over a longer time scale (to examine developmental change). This ambitious, innovative project will provide novel insights into the mechanisms of self-esteem development in a major life transition. It will have a strong impact on the field and has the potential to inform policy allowing for tailoring interventions to promote successful development.

Mots clés : personality development, self esteem development, lifespan development, life transitions and the transition to work, daily diary longitudinal data and experience sampling method

Participants :
- Tilburg University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175572.48 €
Projet OCARINA (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The transition to a low carbon society and energy efficiency by 2050 (“The EUs Green Deal”) will require radical solutions, especially in order to reduce greenhouse gas emissions, which have to be reduced by 80%. The major contributing segments are the development of e-mobility and eco-power generation, which will need highly efficient electric motors to meet the target. This can only be achieved by using high-performance rare earths-transition metal permanent magnets (RE-TM PMs) like Nd-Fe-B in such motors and generators. From this perspective, RE-TM PMs are an important subject of further research with aiming at even improved properties and performances. However, REs are on the EU's list of most critical raw materials, which requires holistic measures encompassing their recycling that will in the future accompany their primal development. There is already a large pool of RE-TM PMs based applications that are already at their end of life (EOL) (hard disk drives for example), the new e-applications like electric vehicles and wind turbines that are about to come to their end of life in the near future. However, the current recycling is too expensive for the EUs to conduct so, that is why the proposed project “nOvel reCycling And ReprocessIng of permaNent mAgnets”- OCARINA proposes a new feasible recycling technology of EOL magnets that would reduce EU dependence of RE imports. With this we are killing two flies in one run, as the new recycling route offers to tailor and improve the magnetic properties inside out, that was up to now impossible. ER is to tackle the proposed thematic is hosted by the Jožef Stefan Institute (JSI), Department for Nanostructured (K7) materials, where the complementary and synergetic knowledge are used for the project success.

Mots clés : permanent magnets, nd fe b, end of life, recycling, reprocessing

Participants :
- Jožef Stefan Institute (Slovénie) — Coordinator, beneficiary, Recherche, subvention : 150040.32 €
Projet DrugsUP (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The transport of nutrients and metabolites across lipid membranes is a critical and essential biological process in both normal and pathological conditions. Specialized integral membrane proteins known as transporters are responsible for the movement of virtually any known class of biologically active molecules across membranes. Perhaps not surprisingly, there is increasing evidence that many drugs in clinical use also employ carried-mediated transport as the predominant entry method into the cell. Understanding the molecular and physiological basis of transporter-mediated drug uptake is therefore a key step toward the development of improved pharmacokinetics and models of toxicity for current and future therapeutically active compounds. We hypothesize that most approved drugs may require specific members of the solute carrier (SLC) family to cross the cell membrane, a phenomenon that would directly affect the compound activity, and that this process is basically underestimated in its importance. To test this hypothesis, the study proposed here aims at identifying SLC transporters involved in the uptake of a well-characterized set of commercialized drugs. The CeMM Library Of Unique Drugs (CLOUD) is a library of 300 compounds selected to be representative of the chemical space covered by all commercially available drugs. Human cell lines carrying deletions on specific SLC proteins will be tested for their ability to resist toxicity or challenges due to CLOUD compounds, allowing us to determine which transporter or family of transporters are involved in the uptake of specific drugs classes. The information derived from these studies will represent an important step forward toward a systematic characterization of the role of carrier-mediated transport in drug uptake.

Mots clés : transporters, drugs, haploid genetics, crispr, cas9, toxicity screening

Participants :
- Austrian Academy of Sciences (Autriche) — Coordinator, beneficiary, Recherche, subvention : 178156.8 €
Projet CHARM (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The transport sector is one of the largest and fastest growing energy consumers, and one of the most difficult sectors to decarbonize. Although there are projections of a rapid increase in low-power electric vehicles, there is still uncertainty in decarbonising high-power transport vehicles (ships and long-haul trucks). The European Union has committed to achieving at least 27% renewable energy share of gross energy consumption by 2030. A practical implementation is to produce advanced biofuels using bio-based technologies e.g. bio/electro/photo catalysis. These technologies can be used either alone or in a combined way to produce desired products e.g. hydrogen, methane, carboxylic acids, and hydrocarbons. Among these options, hydrocarbons are advantageous due to their versatile use and valorisation opportunities. However, current conversion technologies pose significant challenges: (1) whole cell fermentation is vulnerable to many factors (e.g. products inhibition), whist a wide range of by-products may be produced due to diverse pathways; and (2) traditional linear conversion processes have limited sustainability. To tackle these issues, I propose a two-year fellowship (CHARM) based on the Biocatalysis group led by Prof Hollmann in TU Delft. CHARM proposes a novel bio-based circular approach to enable production of light-weight hydrocarbons from both biomass and CO2 by integrating microbial fermentation, bioelectrochemical synthesis and bio-photocatalysis. CHARM will explore production of caproic acid as a platform chemical and its bio-photocatalytic conversion to value added C5 hydrocarbon (i.e. from CO2 to C5H12), whilst fulfilling CO2 recycle. Through this fellowship, I will reach a level of maturity on not only several scientific aspects but also on managerial and industrial aspects that will provide me new career opportunities. The completion of CHARM will contribute to establishing me as a leading researcher in biofuels/bioenergy.

Mots clés : biocatalysis, fermentation, co2 conversion, hydrocarbon, biofuel

Participants :
- Delft University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187572.48 €
Projet INTERACT (Horizon 2020, appel à projets 2017)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

The trend for more electrified automotive applications (MEAA) asks for a new generation of automotive electrical actuation systems, allowing for a more efficient and environmentally friendly mobility and enhancing the driving experience, making it safer, more comfortable and sustainable. INTERACT’s overall objective is to answer the further enhancement of the next generation high-performance sustainable automotive electric actuators (SAEA) by combining high-level scientific research and training activities in a joint academia-industry doctoral programme, focused on solving critical issues (See Section 1.1.2) of the automotive electrical actuation Research & Development (R&D) cycle. The project is a natural continuation of a fruitful collaboration between the beneficiaries: two universities (UTCN and ULB) and three industrial actors. What started as staff exchange collaboration for technological know-how and transfer of knowledge in the field of electrical machines and drives for automotive applications , is now developed, through INTERACT, into a joint doctoral programme, based on common interests and goals, in the field of R&D of next generation of SAEA. More specifically, INTERACT takes advantage of the well-established intersectoral collaboration achievements and of the solid research and training competences and facilities at the beneficiaries for: (i) giving new career perspectives and increasing the employability of four young researchers, by enhancing their creative and innovative potential; (ii) pushing forward and/or extend the industrial partners portfolio with new technological developments to be integrated into the R&D process so they remain and/or enter as an important player in automotive industry ; (iii) strengthen innovation capacity of UTCN and ULB with commercial exploitation of the research.

Mots clés : automotive electrical actuation, mands tools, hil testing, prototyping, experimental validation, sustainable development

Participants :
- Brose Fahrzeugteile (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 304597.92 €
- Université Libre de Bruxelles (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 292320.0 €
- Technical University of Cluj-Napoca (Roumanie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 349307.38 €
- Siemens (Belgium) (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 250560.0 €
- Institutul de Cercetari Electrotehnice (Roumanie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 212260.84 €
Projet MF-RADAR (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The tropical rainforest of the Amazon basin is a global biodiversity hotspot and stores significant amounts of carbon, stabilising the regional and global climate. Deforestation, forest degradation and climate change impacts are posing a threat to its future. This Marie Curie fellowship will develop a systematic integration of geomorphometry methods with satellite remote sensing techniques from Synthetic Aperture Radar to study the floristic-structural associations in the tropical forest of the Amazon, map disturbances and degradation, reduce greenhouse gas emissions and preserve floristic diversity. Its research objectives (RO) areto identify geomorphometric variables related to tree species abundance and richness in Tapajos, Brazil, and structural forest variables from multi-frequency radar satellites (RO1); to analyse tree species, radar data and geomorphometry witha machine-learning (maximum-entropy) approach to produce species probability maps (RO2); to determine the explanatory power of the integrated radar/geomorphometry approach for biomass mapping (RO3); and to estimate the aboveground carbon stocks (RO4). The technical and complementary training objectives (TO) are to learn advanced radar processing skills for forest structure estimation (TO1); to learn effective data integration techniques for multi-frequency radar data and geomorphometric parameters (TO2); to learn how to communicate scientific research to the wider public (TO3); and to acquire complementary and leadership skills (TO4). The fellow will undertake a world-class programme of research and training in Earth Observation research methods, several international secondments, participate in postgraduate training modules and specific researcher development courses in complementary skills. She will transfer her expertise in tropical forest structure and biodiversityof the Amazon to Europe and develop her academic career to reach and enforce a senior academic position.

Mots clés : radar, forest, biomass, topography, remote sensing, geomorphometry

Participants :
- University of Leicester (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet NewPhysicsInSpace (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The ultimate goal of modern particle and astroparticle physics is to discover new physics beyond the standard model. Gravitation provides an infallible signal ofnew physics – the dark matter (DM). Cosmic rays (along with DM direct detection and collider experiments) can shed light on the non-gravitational nature of the DM. Different spectral and spatial deviations of cosmic ray spectra from standard astrophysical predictions can hint possible annihilation or decay signals of DM. The aim of this research project is to work out constraints of the non-gravitational properties of dark matter using cosmic ray data from satellite based experiments like AMS02 and the Fermi LAT, and from Cherenkov, radio and neutrino telescopes. The discovery or exclusion of dark matter annihilation/decay scenarios and the extraction of the properties of DM from that data needs superb understanding of the standard astrophysical cosmic ray background. The proposed research will start with the study of standard cosmic ray backgrounds, including development of dedicated tools like DRAGON. As a new development, using the anticipated AMS02 data we study whether modification of standard cosmic ray production mechanisms in supernovae will be able to explain the observed positron anomaly. In collaboration with DESY and the Univ. of Cambridge the project continues with searching and constraining signals of new physics in charged cosmic rays as well as in photon and neutrino signals. The project is multidisciplinary combining studies of experimental data and theoretical research in particle physics, astroparticle physics, cosmology, astronomy, nuclear physics and astrochemistry. From the personal career perspective, the proposal would enable the applicant to return from CERN to the NICPB, Tallinn, and bring his gathered international research expertise to an EU country.

Mots clés : astroparticle physics, cosmology, astrochemistry

Participants :
- National Institute of Chemical Physics and Biophysics (Estonie) — Coordinator, beneficiary, Recherche, subvention : 148582.8 €
Projet HiFi Brilliancy (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The ultimate goal of this Fellowship, entitled “HIgh-speed FIbre-based BRILLouIn ANalyzer for endosCopY” (HIFI BRILLIANCY) is to enhance the creative and innovative potential of an experienced researcher, helping him to diversify his individual competence through a research project focused on the development of novel tools for optomechanical imagine of biomaterials towards in vivo real-time endoscopy. This will be achieved putting forward the latest methods of stimulated Brillouin scattering enabling recording Brillouin Gain Spectra in biomaterials. The Fellow – Dr Andrei Fotiadi – will be trained in biophotonics, a fast-growing field of science, and medical application. The HiFi Brilliancy outputs will be relevant to the EU Information Science and Engineering sector by offering new cost-efficient technologies for real-time in vivo Brillouin Imaging. Given the huge and fast-growing market of medical diagnostic equipment, the project results have a good opportunity for successful commercialisation. The Fellow will use his present connections to optical equipment manufacturers in EU to develop commercialisation opportunities, and new connections will be established through this project. The project brings together an experienced research Fellow with a strong scientific and engineering background in Brillouin photonics and an internationally growing group of researchers at Opto-Electronics and Measurement Techniques (OPEM) unit (University of Oulu, Finland) with expertise in the area of developing laser-based photonic devices for biomedical imaging. The Fellow will be further supported by medical and industrial expert co-hosts who will help train the Fellow in key skills and support the translational research process. The translational part of the project will primarily be aimed at adapting results of scientific studies to actual conditions of clinical practice. It will permeate the whole project and will be a complex of scientific research and training of the Fellow.

Mots clés : brillouin imaging, brillouin spectrometry, optomechanical diagnostic methods, mechanobiology, endoscopy, elastic and viscous tissue properties, brillouin dynamical gratings, biophotonics

Participants :
- University of Oulu (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202680.96 €