Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet GENRES (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Early life stress (ELS), ranging from prenatal to postnatal challenges such as household dysfunction and child maltreatment, often co-occurs and affects over 60% of individuals worldwide, leading to adverse outcomes like psychosocial difficulties. However, individual responses to ELS vary, with some exhibiting remarkable resilience, such as maintaining high functioning or gradually improving. The GENRES project aims to uncover how genetic and environmental factors interact to foster resilience in individuals exposed to ELS. Using data from four large-scale population-based cohorts, GENRES will identify resilient developmental trajectories from childhood to adolescence and adulthood across emotional, behavioural, and cognitive functions. The project will analyse polygenic profiles (based on multiple polygenic scores) and environmental profiles (derived from multi-systemic family and social factors) that contribute to resilient trajectories (e.g., recovering or competent). Differential susceptibility effects will be tested, focusing on how sex, genetic predisposition, and temperament interact to influence individuals respond differently to environments, both negative and positive. The findings from each cohort will be integrated through meta-analysis, offering a comprehensive understanding of resilience to ELS across diverse populations and contexts. By bridging genetic and psychosocial research, the project will also contribute to a broader understanding of resilience, reducing stigma and shifting the focus from individual blame to systemic support. The outcomes of GENRES will inform public health strategies and interventions tailored to individual genetic profiles and resilience-promoting environments. Executing this project at the Max Planck Institute for Psycholinguistics will enhance my interdisciplinary expertise and support the development of innovative approaches to study resilience, thereby improving health and well-being for those exposed to ELS.

Mots clés : early life stress resilience mental health cognitive functions developmental trajectories genetic factors polygenic scores psychosocial systems

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 217076.16 €
Projet MYO_MATRIX (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Healthy skeletal muscle has a powerful capacity to regenerate after an injury. On the opposite, muscular dystrophies (MDs) are devastating diseases where these regenerative capacities are overwhelmed and the muscle fibers are progressively replaced by fibrosis, leading to muscle loss and finally to death. Fibrosis is the final outcome of excessive production of molecules constituting the extracellular matrix (ECM). However, ECM alterations in MDs have been considered only as the result of muscle damage, the inflammatory response, or an unbalanced degradation/synthesis by fibroblasts. MYO_MATRIX is a 2-year project proposing a innovative point of view by shifting the focus to the extracellular environment, i.e., ECM, as an active partner impacting on muscle cell properties. The final goal is to decipher the role of ECM in skeletal muscle homeostasis and to define the molecular ECM components at work during MDs. Specific objectives include the combination of proteomics, transcriptomics, in situ 3D tissue analyses and ex-vivo functional cell experiments. Comparison of muscles in various conditions (normal, regenerating and dystrophic) will define key molecular determinants controlling beneficial ECM remodeling (in healthy regenerating muscle) versus detrimental fibrosis (in dystrophic muscle). The transdisciplinary (biochemistry and biology) and multilevel (protein, mRNA, cell, tissue) approach will identify new components in MDs. Such an outside-in approach has never been tested so far in skeletal muscle. The project, implemented by a biochemist researcher in a biology host lab (Université Claude Bernard Lyon 1 at Institut NeuroMyoGène), will identify the molecular alterations of ECM in MDs and how they affect the behavior of cells that contribute to muscle homeostasis. The identification of the ECM molecular determinants is the ambition of the project, to propose therapeutic targets for MD patients for whom an effective treatment does not exist yet.

Mots clés : duchenne muscular dystrophy, extracellular matrix, proteins, skeletal muscle, terapeutic targets

Participants :
- Lyon-I université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206859.39 €
Projet I am SMART (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

To tackle the challenges of climate change, there is a growing emphasis on developing green, eco-friendly resources alongside advanced digital technologies. The construction industry is undergoing significant transformations in both materials and digitalisation. With the European Union facing resource constraints, there is a pressing need for innovative solutions to replace CO2-intensive materials and conserve natural resources. In response, the construction sector is increasingly adopting sustainable practices and materials, particularly in concrete technology. These efforts aim to reduce the environmental impact of concrete production, extend structural lifespans, minimise resource consumption, and improve the reliability of new construction technologies. The I am SMART project seeks to address these challenges by promoting a fully automated, greener, circular economic model for production and consumption. The project specifically focuses on developing a novel, intelligent 3D printing technology, supported by artificial intelligence (AI), capable of producing highly accurate printed structures. Additionally, the project aims to develop environmentally friendly cementitious feedstock derived from construction and demolition waste (CDW), as well as low-grade clay minerals, suitable for use in load-bearing building blocks. The project intends to imbue the structures with smart properties by integrating graphene-based materials (GBMs) into the feedstock, significantly enhancing their service life and reducing maintenance costs. The expertise of the Fellow, Dr. Mehdi Chougan, and the supervisor, Prof. Pawel Sikora, is complementary and will facilitate the development of novel construction materials and technologies through a reciprocal knowledge transfer and comprehensive training activities for the Fellow. The project will involve collaboration with world-leading academic and industrial partners, thereby enhancing the overall quality and impact of the research.

Mots clés : additive manufacturing, 3d printing, clay, cementitious materials, low carbon, limestone calcined clay, graphene, ai assissted system, 3d scanning, calcined clay

Participants :
- Imperial College London (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de technologie de Poméranie occidentale (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 163166.16 €
- Vinci construction (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université métropolitaine de Manchester (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SyDy RoCe (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Roots must tightly balance uptake of ions and water from the soil into their vasculature. For this purpose, they developed complex systems of barrier mechanisms. The endodermis layer encircles the vasculature and via the casparian strip (CS) and suberin acts as such a barrier. The CS blocks flux outside of cells (the apoplastic flux), and leaves only the symplastic pathway open for the exchange of molecules. Endodermis cell walls undergo suberisation dependent on phloem pole (PP) or xylem pole (XP) association. The unsuberised XP associated endodermis (XPAE) cells are speculated to fulfil an important role as transport highways. Despite this close association to the underlying vasculature, little is known about the dynamics of endodermal symplastic flux in the different poles.  I aim to elucidate differences in the cell-to-cell exchange of the endodermis in relation to barrier status and radial positioning. For this, I will use a photoconvertible fluorophore to quantify symplastic flux by XP versus PP association and suberisation status. Next, I will generate tools to specifically manipulate XPAE cells, by forcing them to close off their symplastic connections by plasmodesmal callose deposition, or to undergo suberisation.  I will use these tools to assess phenotypic differences on plant growth under stress conditions that affect endodermal barrier development (e.g. low iron, phosphate, and zinc). Together, this will result in unprecedented insights into how the endodermis achieves the specific transport of water, and ions, and will allow me to update models with radial information on endodermal selectivity and connection to vascular transport.

Mots clés : plant sciences root nutrient uptake suberin plasmodesmata symplastic flux endodermal barrier synthetic biology

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 173847.36 €
Projet ClickBioGel (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Cartilage injury afflicts over a million patients annually in Europe and it is a serious problem due to Europe's ageing population. Hydrogels are promising materials for cartilage tissue regeneration in case they are designed accordingly. The use of synthetic materials suffer from biocompatibility and toxicity problems while natural materials can have drawbacks such as low mechanical strength, limited types, insufficient integration with host tissues and easy contamination with bacteria due to high biocompatibility. ClickBioGel aims to fill this gap through fabrication of bio-based hydrogels for cartilage tissue regeneration using a ternary material system composed of collagen, hyaluronic acid and K-carrageenan to advantage from their synergetic effects, and the “Click” chemistry concept, particularly thiol-ene and Diels-Alder reactions, for the selective and high yield chemical crosslinking of the hydrogels under mild reaction conditions. Chitin nanofibrils will be dispersed in the hydrogel precursor for enhancing the mechanical properties as well as antibacterial and bioadhesive characteristics while RGD peptide will be attached on the hydrogels for cell-adhesiveness. The production of the hydrogels will mainly be in three categories as photocrosslinked hydrogels, 3-D printed hydrogels and light-free injectable hydrogels, which will allow the tunability according to the needs. In vitro cell viability, cytotoxicity and chondrogenesis performance of the hydrogels will be evaluated. With the support of my supervisor (Prof Sangermano), his infrastructure at Department of Applied Science and Technology, as well as the interdepartmental biomedical research centre and the multidisciplinary additive manufacturing research centre at Politecnico di Torino, the fellowship will train me on hydrogel synthesis, photocuring, 3D-printing and biological analysis and act as a pilot for my own ERC starting grant to be an independent researcher.

Mots clés : photocrosslinked hydrogels, 3 d printed hydrogels, light free injectable hydrogels, diels alder reaction, thiol ene reaction, click chemistry, cartilage tissue regeneration

Participants :
- École polytechnique de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet 2DTWIST (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : TERMINATED

The discovery of superconductivity in twisted bilayer graphene in 2018 gave rise to twistronics. Twistronics is the study of how the reciprocal angle between layers of two-dimensional materials can modify their properties. Twisted structures present a Moiré lattice and exhibit very different electronic behavior, from non-conductive to superconductive, which depends significantly on the angle between the layers. To date, several techniques have been developed to fabricate layered heterostructures with controlled rotation between the layers, but the Moiré patterns have largely been static. Recent works have demonstrated the tuning of Moiré patterns by using the atomic force microscopy technique to rotate adjacent layers, allowing to study the evolution of properties as the twist angle varies. Dynamic control of rotatable heterostructures will provide a relatively simple platform for exploring exotic quantum effects. Thanks to the observation of these phenomena, a new playground will be created with disruptive technological repercussions, from quantum computing to optoelectronics. In 2DTWIST, I will develop a new technique that allows active, dynamic, and automated control of Moiré geometry in 2D heterostructures in a single device, allowing more precise positioning and in-situ twist of adjacent layers, by electrostatic actuation. Thanks to this approach it will be possible to explore how emergent properties depend on Moiré geometry and to achieve controlled and uniform properties within a single device.

Mots clés : 2d materials, twistronics, mems, actuator

Participants :
- Laboratoire fédéral d'essai des matériaux et de recherche (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École polytechnique de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 147855.2 €
Projet VIBRATIONCLEAR (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Earthquakes are one of the deadliest and costliest natural hazards. In Europe, earthquakes have been responsible for more than 200,000 deaths and damage worth at least 250 billion euros during the 20th century. In Italy alone, more than 400 destructive earthquakes have been documented. In more recent history, the Central Italy earthquake in 2016 killed 297 people and caused damage worth at least 4 billion euros. VIBRATIONCLEAR proposes the use of inerter-based vibrating barrier (I-ViBA) for earthquake protection of a cluster of building structures. The I-ViBA is unique because unlike any other currently available earthquake protection technologies, the I-ViBA is buried in the ground and tuned to protect surrounding structures without being directly in contact to them through a structure-soil-structure interaction (SSSI) mechanism. The I-ViBA can be a solution for a low-cost seismic protection technology for existing buildings as one I-ViBA can be designed to protect many surrounded structures, something that has never been explored before. Aiming to address the apparent gap, this VIBRATIONCLEAR project sets two key objectives: (a) propose a novel I-ViBA and its optimisation method; and (b) perform 2D and 3D numerical finite element simulations considering a more realistic environment (multiple I-ViBA with a cluster of building structures). Using both analytical and numerical methods, the I-ViBA will be accurately designed, modelled and simulated using finite element software with various types of earthquake ground motions.  With the support of my supervisor (Prof Marco Domaneschi) at the Politecnico di Torino, the Fellowship will train me in earthquake engineering and structural dynamics and act as a pilot for my own ERC Starting Grant on seismic protection technology. Ultimately, the project seeks to provide low-cost seismic protection technology for buildings to protect people from earthquakes.

Mots clés : inerter, damper, earthquake engineering, structural dynamics, seismic protection technology

Participants :
- École polytechnique de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet TREX-MPs (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Plastics has become one of the most urgent environmental issue due to their resistance to natural degradation. Over time, they break down into microplastics (MPs), which, at lengths less than 5 mm which bring a serious problem, especially due to air and water pollution, causing serious complications to the quality of human, animal, and plant life. Several emerging strategies are being explored to combat MPs pollution, with metal oxide semiconductors emerging as effective and sustainable photocatalysts for degrading MPs, offering promise in addressing this social and environmental challenge. Metal oxide semiconductors, when energized externally, act as photocatalysts by generating charge carriers, which, in the presence of water and oxygen, lead to the formation of reactive oxygen species (ROS). Therefore, in-depth research on ROS generation and how to improve the photodegradation efficiency of these materials is an essential factor in translating viable new technologies from the laboratory to the market. Regarding MPs, there is a lack of molecular models for ab initio calculations and knowledge about how ROS function and their mechanisms in the photodegradation process, which presents significant challenges. Therefore, the TREX-MPs project aims to investigate the photodegradation of MPs using metal oxide semiconductors thought ROS interaction. This will be achieved applying theoretical and experimental approaches, with a focus on studying the degradation of polystyrene MPs using TiO2 and CeO2. The results will contribute to the literature in this direction, and will facilitate the remediation of MPs in wastewater, which can be used in water treatment systems more effectively, at a scalable level, and in an environmentally beneficial manner. Thus, there is an urgent need of knowledge on how to deal with MPs, from their generation to their elimination, following the criteria of green chemistry.

Mots clés : metal oxide semiconductors

Participants :
- Methodist University of São Paulo (Brésil) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Sorbonne Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet ROTurb (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

"Resolving Ocean Macroscale Turbulence" (ROTurb) is a proposal to fund a fellowship to be carried out by the Experienced Researcher (ER) Simone Silvestri at the host institution Polytechnic University of Turin, Italy (POLITO) in the Department of Environment, Land and Infrastructure Engineering (DIATI) under the supervision of main host Professor Jost von Hardenberg. The aim of the proposed work is twofold. From a scientific perspective, the goal is to investigate the role of macroscale turbulent processes in ocean models through a hierarchy of coupled ocean sea ice simulations that follow the ocean model intercomparison project OMIP2. Regarding technological innovation, the aim is to develop a submesoscale permitting model that runs at climate-relevant scales. Macroscale turbulence in the ocean, broadly subdivided into mesoscale and submesoscale features, is the primary driver of the lateral transport of heat, carbon, and nutrients. Furthermore, submesoscales, associated with surface fronts, have been suggested to play a pivotal role in determining the vertical transport of heat and carbon in the ocean and modulating air-sea fluxes. However, due to their small scale, these processes are typically not represented in global ocean models. The ER and colleagues have recently developed a model that, by leveraging Graphical Processing Units (GPUs), achieves computational performance up to 100 times higher than state-of-the-art models. This new model, called ClimaOcean, enables unprecedented high-resolution simulations, making it possible to explore kilometer-scale turbulent processes and their impact on climate-relevant metrics within a global ocean framework for the first time.

Mots clés : physical oceanography, ocean turbulence, high resolution modeling

Participants :
- École polytechnique de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet CLIMATEJUSTHOME (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Climate change is profoundly impacting cities and their inhabitants, leading to increased infrastructure failure, food and resource shortages and death. Research has shown that vulnerable households are not only the most exposed to these effects, but also experience displacement when cities implement green, climate-adaptive interventions that change housing markets and their affordability. In Europe, the carbon neutrality goals set by the European Green Deal will trigger unprecedented transformations that might exacerbate these vulnerabilities. In a context where new climate-adapted housing is reaching largely middle- and high-income groups, more research is needed to understand how housing access can be ensured for all residents in green, climate adapted cities. CLIMATEJUSTHOME fills this gap through an innovative mixed methods approach that builds from an in-depth understanding of vulnerable households’ lived experiences and the unique insights they offer to advance just urban climate adaptation, housing planning and policy-making. Using a case study strategy focusing on Spain’s greenest city Vitoria-Gasteiz, I will deploy policy analysis, spatial analysis, ethnography and ethno-spatial mapping workshops to generate data housing and climate (in)justices towards building new theory and knowledge on climate just housing.  With the support of my supervisor (Prof Lancione) and his cutting-edge European Research Council (ERC) Beyond Inhabitation Lab at the Politecnico di Torino, as well as the award-winning Basque Centre for Climate Change BC3, the Fellowship will train me in ethnography, intersectional analysis and ethno-spatial mapping and act as a pilot for my own ERC Starting Grant on climate just housing. Ultimately, the project seeks to expand theoretical and practical knowledge about how cities embracing climate change adaptation strategies can develop just housing and urban interventions towards carbon neutrality.

Mots clés : urban climate change adaptation, housing struggle, intersectionality, eviction, displacement

Participants :
- Université autonome de Barcelone (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École polytechnique de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €