Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet TERMS-Ocean (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Global oceans are currently changing at a faster rate than at any other time over the last 300 million years, exposing marine organisms to multiple environmental stressors, such as climate change and ocean acidification (OA). Coastal marine invertebrates are globally important in terms of the ecosystem services and functions that they provide, hence it is vital to determine whether they can adapt and evolve to cope with these multiple stressors at the rate at which they are occurring. The TERMS-Ocean project will address this key question by determining the role of transgenerational phenotypic plasticity (TPP) in the response of a keystone marine invertebrate to the combined impacts of climate change and OA. TPP examines the potential for phenotypic plasticity in offspring in response to parental stress and has been shown to alleviate physiological responses in single-stressor studies; however there is no evidence to date as to whether TPP can operate when multiple stressors are experienced in combination. Here, a novel common garden experimental design will be employed to examine the transgenerational responses of the sea urchin Paracentrotus lividus to the combined effects of elevated temperature and OA in order to assess whether TPP plays a role in alleviating the effects of these stressors when experienced in combination. This project will be pivotal for my personal development to become an independent researcher and offers me the unique opportunity to work in a top 10 Russel Group University with a global reputation for excellence in environmental and climate change research. Exeter Biosciences is a leading institute in environmental biology and ecology and provides excellent opportunities for academic training and personal career development. A fellowship at Exeter will expose me to novel ideas and input from renowned researchers, offer me exciting opportunities for knowledge exchange, and have a strong impact on my personal and scientific development.

Mots clés : climate change, ocean acidification, transgenerational phenotypic plasticity, physiological responses, temperature, sea urchin, paracentrotus, larval development, marine environment

Participants :
- University of Exeter (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet SANDLINKS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Global raw material extraction grew by 94% between 1980 and 2010 to reach a total of 70 Bt per year in 2010, and is predicted to reach 100 Bt by 2030. Sand and gravel are the most extracted group of materials worldwide. The construction industry is behind this huge demand. Sand is critical for concrete, land-reclamation projects or combating coastal erosion. Despite enormous advances being made to understand and quantify the footprint of human infrastructure, the “off-site” impacts derived from the provision of construction minerals are largely ignored. An ever-increasing demand for these resources is putting more and more strain on limited deposits, which has led to conflicts around the world and will likely lead to a “tragedy of the sand commons” if sustainable mining cannot be achieved. The project aims to understand how an increasing demand for sand affects complex human-nature dynamics and connects with environmental and sustainability challenges through mining, transportation, trade and consumption. I will apply and operationalize a systems integration approach, the telecoupling framework, and conduct studies at multiple scales to strengthen the knowledge base and contribute to develop possible pathways into a sustainable management and governance of construction minerals. This research will combine research methods such as evidence synthesis, material flow analysis and agent-based modeling. The research is proposed as a 3-year GF. MSU will be my host during the outgoing phase in USA and I will be hosted at UCL in Belgium during the third year. The MSCA will allow me to consolidate my transition to this field and become a pioneer in the application of an integrated perspective to address the environmental and socioeconomic interlinkages resulting from sand supply and demand. This research has great potential for scientific advancement and it will open up the best career possibilities for my career and new collaboration opportunities for the host organisations.

Mots clés : sustainability sciences, mining, construction minerals

Participants :
- Université Catholique de Louvain (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 248425.92 €
- Michigan State University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet NEMOSID (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Global sea level changes are grand humanitarian challenges in the 21st century and beyond. The biggest contributor and uncertainty to sea-level projections is dynamical ice-mass loss from the Antarctic Ice Sheet. Fast-moving ice primarily flows by sliding over weak and water-saturated sedimentary deposits that are reshaped into undulations and depositional wedges in the process. Current ice-sheet models do not account for transport of sediment under ice, and commonly assume that basal friction increases if ice flow accelerates. In this project I propose to address these shortcomings by deriving a realistic coupled framework for glacier ice, water and sediment. The sediment model is constrained by laboratory experiments and is coupled to a new model of subglacial hydrology. The ice-water-sediment model is compared to landforms and sedimentary deposits from previous glaciations, as well as contemporary ice sheet flow patterns. The framework allows analysis of climate-perturbation sensitivity, with particular investigation into the dynamical evolution of ice flow and basal environment. By incorporating previously neglected processes, the developed model framework will improve the accuracy of predicted global-mean sea-level change in the future.

Mots clés : glaciology, ice sheet modeling, soil mechanics

Participants :
- Aarhus University (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 219312.0 €
Projet CORNELIA (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Globally less than a quarter of national parliamentarians are women (UN Women). Meanwhile corruption, in its various forms, persists and Globally less than a quarter of national parliamentarians are women (UN Women). Meanwhile corruption, in its various forms, persists and seems only weakly constrained by democracy. Existing studies evaluate the impact of female politicians on policies decisions and comparison between the decisions of female and male politicians. Filling the gaps in the literature, CORNELIA (CORruption aNd fEmale poLItical pArticipation) will investigate the impact of female politicians on corruption scandals at municipal level and other crimes and the possible differences in media coverage between female and male politicians involved in these scandals. More specifically, it will investigate the following research questions: 1) examine the impact of female politicians on the amount of corruption and scandals, taking advantage of close mixed gender races in Italy and the US; 2) develop measures of the media coverage of corruption scandals and examine whether coverage differs for female and male politicians in Italy and US, and furthermore whether this coverage ameliorates corruption differently; 3) examine the impact of gender quotas on candidates’ lists on the level of corruption and scandals, taking advantage of the gender quotas introduction/abolition at local level in Italy. The research question will be answered using a novel dataset for two different developed countries:1) Italian local data from 1993 to 2019 covering local elections and administrations, corruption and new measures describing media coverage of corruption scandals at the local level, developed by the project; 2) US state level data from 1976 to 2019 covering state level elections and administrations for the 52 States, combined with data on female representation in state governments with corruption data and information on the media coverage of state-level corruption scandals.

Mots clés : political economics, gender economics, crime, corruption

Participants :
- University of York (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet Rehab-Assessment (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Globally, 15 million people suffer a stroke every year, causing 6 million deaths and leaving another 5 million permanently disabled, which makes stroke the second leading cause of disability. In the Europe, it is the most common cause of morbidity and long-term disability, and has significant socioeconomic consequences for patients, their partners and society. Thus far, upper limb weakness remains the biggest and most challenging disability, due to the complexity of movement required in daily living and its generally slower and less complete recovery. More than 50% of stroke survivors still have upper extremity hemiparesis one year after stroke. Neuro rehabilitation is the main approach to improve upper extremity motor outcome, and previous studies have demonstrated that patients can regain considerable motor functions after intensive training. With the number of people surviving a stroke soaring, more and more rehabilitation programs are delivered with minimal involvement of a physiotherapist due to limited resource available, and the success of this approach depends on the accurate assessment of stroke patients’ movement impairment. In collaboration with with the National Demonstration Centre in Rehabilitation Medicine, Leeds Teaching Hospitals NHS Trust, my vision is therefore to establish a comprehensive, quantitative, objective and personalised Motor Impairment Index (MII), via benchmarking the impaired arm movement to healthy arm mirrored exercise to quantify the motor impairment. This approach will increase the likelihood of successful rehabilitation leading to improved quality of life for millions of people affected by stroke. This application focuses on developing innovative healthcare technologies for stroke patients; but it could also potentially benefit millions of people with conditions such as multiple sclerosis, brain tumours and spinal cord injury, as well as people with musculoskeletal conditions or trauma.

Mots clés : wearable sensing, rehabilitation, machine learning

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet ALECS (Horizon 2020, appel à projets 2016)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

Globally, software-based systems are increasingly important to economic activity and to the normal functioning of our everyday lives. The scope, scale and interconnected nature of such systems are increasing rapidly, with the potential consequences of failure, security breaches or malfunction becoming a growing cause of concern. Evolving Critical Systems (ECS) that change over time (“evolving”), and strategically important to their users (“critical”), are increasingly prevalent in software development, from business-critical systems (e.g. airline websites) to safety-critical systems (e.g. automotive braking control system). Advanced Learning in Evolving Critical Systems (ALECS) is an innovative fellowship programme providing intersectoral and interdisciplinary training in strategic priority areas in software research. The aim of ALECS is to develop the next generation of skilled researchers who will gain hands-on experience developing cross-disciplinary and entrepreneurial skills through individual research projects with a mandatory 3-6 month intersectoral secondment to an industry partner during their fellowship. The ALECS Programme will fund 26 two-year incoming fellowships to Ireland in the area of ECS, with fellows will be recruited during 2 calls for proposals over the 54 month duration of the project. ALECS thus will generate a diverse, mobile, skilled workforce and will contribute to European research and innovation. While developing young researchers, ALECS will directly contribute to sustainable economic growth through supporting evidence-based research to drive innovation and new product development. ALECS will provide the international mobility, intersectoral exposure and interdisciplinary research opportunities that are essential to develop the scientific leaders of tomorrow.

Mots clés : software engineering, software change, run time adaptivity, development methods, evolving critical systems, maintenance, reliability, safety, security

Participants :
- University of Limerick (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1840800.0 €
Projet GlySign (Horizon 2020, appel à projets 2016)
Action : Doctoral Networks - Industrial Doctorates
Panel : Life Sciences
Statut du projet : CLOSED

GlySign is a research training network for the translation of glycomic clinical biomarkers for Precision Medicine (PM). Complex, distinctive changes occur in the glycomics profiles or - Glycan Signatures - of human glycoproteins during progression of many chronic diseases including cancer and inflammatory conditions. The three beneficiaries of the GlySign Consortium have been instrumental in contributing to knowledge in this field through development of glycomics technology and discovery of clinically important novel glycan biomarkers in a variety of diseases. Glycan signatures have great potential for adding useful diagnostic and prognostic information in PM. However, advancement of this field is slow because (a) glycans have immense structural complexity resulting in major technical challenges for their analysis and (b) there is a lack of experts with required glycoanalytical skills. GlySign will address this gap by training six young scientists within an innovative training-by-research programme with high industrial-academic mobility to eventually push forward the translation of novel glycomics-based diagnostic tools into clinical practice. This will be achieved by further developing a range of selective and sensitive glycomics technologies for the analysis of samples from patients and healthy controls in close collaboration between industry/academia as well as clinical chemists and clinicians who will be the end users of GlySign’s final products. To this end, we will focus the training on clinical glycomics applied to four model diseases implicating changes in the glycosylation of circulating proteins specific to disease progression or subtype, i.e. diabetes, prostate cancer, fetal and neonatal alloimmune thrombocytopenia and rheumatoid arthritis. Due to its strong industrial and translational focus, GlySign will, moreover, fill a current gap in the market by establishing new in vitro diagnostic platforms for clinical exploitation of glycomic biomarkers for PM.

Mots clés : clinical chemistry

Participants :
- Sanquin (Pays-Bas) — Partner, organization partner, Recherche, subvention : 0.0 €
- Genos (Croatia) (Croatie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 495522.0 €
- Prozomix (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Max Planck Society (Allemagne) — Partner, organization partner, Recherche, subvention : 0.0 €
- Ludger (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 546575.76 €
- Leiden University Medical Center (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 510748.56 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet NEWCARBOVAX (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Glycoconjugate vaccines have provided enormous health benefits globally, but they have been less successful in some populations at high risk for developing disease. They are composed by a sugar antigen covalently linked to a carrier protein. The traditional hypothesis of immune activation by glycoconjugate vaccines suggests that only peptides generated from glycoconjugate processing can be presented to and recognized by T cells, and this contribution is crucial for their immunogenicity. In most cases, conjugation processes have been set-up empirically. Recently, new findings offer a rational explanation for how conjugates work and may render vaccine development a more straightforward process. In contrast with the classical mechanism, this new model suggests that carbohydrate presentation to the T cell by antigen-presenting cell may strongly enhance antibody response. The key strategy is to conjugate the carbohydrate to peptides which anchor the conjugate via MHC class II and allow the sugar epitope to be presented via the T cell receptor. Application of this principle resulted in a GBSIII vaccine strongly protective in a mouse model and 50–100 times more immunogenic than a traditional vaccine composed by random linking of the sugar on a protein carrier. Although the principle has been demonstrated much remains to be done to generally apply the concept to generate vaccines for clinical use. In the proposed study, we will extend the approach by analysing different variables (peptide carrier, glycan chain length, conjugation chemistry and microbial antigen), with the aim of using the increased understanding of basic immunological mechanisms to develop a new translational platform for optimized and cost-effective carbohydrate-based vaccines. Innovative strategies of conjugation chemistry will be also evaluated to generate new therapeutics with chemical properties designed in light of specific information on antigen presentation.

Mots clés : vaccine, glycoconjugate, conjugation chemistry, infectious diseases

Participants :
- Harvard University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- GlaxoSmithKline (Italy) (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 244269.0 €
Projet PoreSelect (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Glycoprotein therapeutics are widely seen as the next generation of drugs. 80% of new therapeutic drugs in phase 3 development are ‘biologics’. However, the early detection of critical glycosylation changes in biopharma pro-duction (i.e. in the drug producing cells) and the rapid and sensitive identification and separation of closely relat-ed protein-drug glycoforms presents an industry wide problem. This project aims to develop a low-cost and easy-to-produce glycopeptide separation platform. This will be based on highly porous polyHIPE structures obtained from fast and scalable polymerisation and subsequently functionalised with reactive groups. The latter will be employed in the conjugation with novel recombinant lectins that have very selective carbohydrate-binding prop-erties. The separation of closely related glycoproteins will be investigated. Moreover, the integration of the lectin conjugated porous polymers into a device format will be addressed. This is a highly interdisciplinary project at the interface of polymer and material science, biotechnology and separation science. The applicants diverse experi-ence in academic and industrially informed projects makes him an ideal match for this project. It provides a unique environment for the researcher to develop his skills supported by unique scientific and complementary training and accelerate his academic career in applied material science. The dissemination of research results will target the professional audience as well the general public through outreach activities.

Mots clés : emulsion templating, glycoprotein separation, bioligand conjugation

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175866.0 €
- Dublin City University (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PATGlycoPrint (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Glycosylation of therapeutic antibodies is one of the most critical quality attributes (CQAs) in biopharmaceutical manufacturing because of its strong impact to the treatment efficacy. Many parameters in the production process including upstream cell culture and downstream purification can significantly change the antibody glycosylation profiles. Therefore, monitoring and quality controlling of glycosylation is central to ensure high quality and consistent products. Unfortunately, this requires advanced analytical equipment and procedures that are expensive and time consuming and not suitable for on-line applications. Process analytical technologies that enable real-time monitoring of glycosylation during the production process would thus be a game changer in the biopharma industry. The aim of this research action is to develop and evaluate a new process analytical technology based on an innovative nanoplasmonic glycan-binding array that can detect the glycosylation patterns of downstream and upstream samples immediately or in a few minutes, respectively. The proposal is established to support the experienced researcher (ER), who wish to resume research in Sweden after a career break, and to enhance the ER´s employment opportunities in both academic and industrial sectors by an extensive two-way exchange of knowledge between the host and the ER as well as innovation and networking opportunities. The research project includes different branches of knowledge including biosensors, nanomaterials, biomanufacturing, analytical chemistry as well as surface, organic and peptide chemistry. In line with the MSCA-2018 Work Programme, this broad interdisciplinary training is expected to diversify the ER competence and greatly impact the ER’s future career while developing and exploring new technologies that can dramatically improve current strategies for bioproduction.

Mots clés : nanoplasmonics, glycosylation, process analytical technology, antibodies, oboc, combinatorial libraries

Participants :
- Linköping University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203852.16 €