Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet REDCOAT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The emergence of antibiotic-resistant superbugs necessitates the development of innovative antimicrobial strategies. The "Revolutionary Square-Phase 2D Materials for Advanced NIR-active Antimicrobial Coatings (REDCOAT)" project aims to address this challenge by leveraging the unique properties of square-phase transition metal dichalcogenides (TMDCs), specifically MoS2 and WS2, to design advanced antimicrobial coatings on titanium implants. REDCOAT will explore the synthesis, surface modification, and application of square-phase TMDC nanosheets, targeting their integration into next-generation NIR-active antimicrobial coatings.  MoS2/WS2 nanosheets will be synthesised with precisely controlled dimensions (100-500 nm edge lengths, 3-10 nm thickness) to exploit their NIR absorption and photothermal conversion capabilities. These nanosheets will be functionalized with an Iron-Gallic Acid-based metal-phenolic network (MPN) to enhance the interaction with bacterial membranes while ensuring biocompatibility. The functionalized TMDCs will be uniformly coated onto Ti6Al4V alloy implants, aiming for a coating thickness of 10-50 µm and surface roughness of 50-200 nm, optimised for effective antimicrobial activity and improved osseointegration.  To elucidate the interaction mechanisms between these coatings and bacterial cells, molecular dynamics (MD) simulations will be performed at 310 K with femtosecond resolution. These simulations will focus on the deformation of lipid bilayers and pore formation under different TMDC coverage levels (5%, 10%, 20%), providing insights into the antimicrobial efficacy of the coatings. Complementing this, in vitro biocompatibility studies will be conducted using human mesenchymal stem cells (hMSCs) seeded on the coated Ti6Al4V discs, assessing cell viability, proliferation, and differentiation. The antimicrobial efficiency of the coatings will be tested against common pathogens and superbugs.

Mots clés : 2d materials 2d square transition metal dichalcogenides nir active antimicrobial coatings iron gallic acid based metal phenolic network molecular dynamics superbugs titanium implants infections

Participants :
- université polytechnique de Łódź (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 163166.16 €
- Université Paris-Saclay (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet AtheroGLP1 (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cardiovascular diseases (CVD) are highly prevalent in Europe, causing more than 3.9 million deaths yearly. Atherosclerosis, a chronic inflammatory disease of the arterial wall, is the main underlying cause of CVD. Available strategies to treat and prevent atherosclerosis remain suboptimal, therefore, better understanding of its regulatory mechanisms is required to design new approaches to treat this inflammatory disease. Recent cardiovascular outcome trials demonstrated that GLP-1R agonists (GLP-1RA) reduce the rates of major cardiovascular events. This GLP-1RA effects are hypothesized to reflect modifications on atherosclerosis, through anti-inflammatory actions. However, the mechanisms linking GLP-1R activation to control of atherosclerosis and vascular inflammation, as well as the cells/tissues mediating these effects, are far from understood. The main aim of my proposal is to identify the mechanism by which GLP-1RA regulate atherosclerosis regression, offering a unique and innovative opportunity to study the role of yet unexplored GLP-1R+ cell types (vascular smooth muscle cells, and neurons of the enteric and central nervous system) mediating its effects. The multidisciplinary perspective adopted, combining my background in academic research with preclinical models, the experience in biomedical research of the host supervisor, and the clinic/translational perspective of the partner supervisor, gives this AtheroGLP1 project with the strong potential to identify novel mechanisms that are expected to have immediate translational importance for targeted use of GLP-1RAs in the clinic to treat atherosclerosis and CVD. Importantly, this proposal will allow me to gain transferable competences and get trained in the latest in vivo and molecular techniques to assess vascular and systemic inflammation, letting me to reach scientific maturity to stablish a similar facility at the host institution, promoting my transition to become an independent researcher in the ERA.

Mots clés : glp 1, glp 1ras, atherosclerosis, vascular inflammation

Participants :
- Université de Saint-Jacques-de-Compostelle (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252724.32 €
- Mount sinai hospital (Canada) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet Plas-ID (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Single-molecule protein sensing and sequencing technologies are emerging on the horizon as new powerful tools, which ultimate goal is the characterization of the proteome, namely the total set of proteins made by a cell or organism. Despite recent advances, challenges in terms of full-length reads, high throughput and intrinsic complexity related to the larger set of building blocks (i.e. 20 amino acids) still remain. Furthermore, the unambiguous identification of proteins at low concentration is an open issue for conventional techniques, such as Mass Spectroscopy and ELISA. I aim to develop a plasmon-enhanced single-molecule sensing device to track and identify proteins, combining a dual-color amino-acid-specific technique to label the proteins and the enhancement to the fluorescence provided by properly-designed plasmonic nanostructures integrated within a nanochannel-based device. The plasmonic nanochannel is filled with a custom-made gel to slow down the motion of proteins and separate them by their molecular mass during the electrophoretic migration, meanwhile plasmonic nanostructures enhance the fluorescence signals acquired from each individual dual-color labelled protein. I will focus on the optimization of the device and testing its capabilities for the discrimination of clinically-relevant isoforms of Vascular endothelial growth factor (VEGFa) family. I will tackle the challenge of isoforms identification even further, by using the device to discriminate between VEGFa and VEGFb, which differ for only six amino acids at the C termini. Results from this work will provide a technique for the identification and quantification of protein isoforms with single-molecule resolution. Potentially, the use of this diagnostic tool will provide new insight into the role of VEGF isoforms and their up/down regulation into several diseases and in turns, also new avenues for targeted therapeutics.

Mots clés : single molecule sensing, protein identification, plasmonic nanostructures, dual color labeling, nanochannels

Participants :
- Technion - Institut de technologie d'Israël (Israël) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Technion - Institut de technologie d'Israël (Israël) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 184698.24 €
Projet AviCulture (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Lessons from Mesoamerican cities are well-suited to address many problems with feeding urban populations today, as large cities thrived in this region in the absence of large, domesticated animals. While we know that residents of Teotihuacan consumed a plant-heavy diet, supplemented with wild animals harvested from local ecosystems and some husbandry of small animals, like turkeys, there are still many gaps in our understanding of Teotihuacan’s food production system. AviCulture tests two hypotheses to better our understanding sustainable food production in the city. 1. Residents practiced low-intensity husbandry of turkeys and quails at the household level. 2. Aquatic birds, a proxy for lake exploitation, were more important to urban subsistence than current evidence suggests. The project will test these hypotheses across multiple assemblages at the city by integrating common zooarchaeological analysis with proteomic analysis to improve taxonomic identification of bone and egg remains and examining eggshells to assess embryonic development. The findings of this research will speak to the organisation of two important food production strategies for the city and highlight the importance of avian fauna and lacustrine resources in investigating the development of urban economies during the classic period.

Mots clés : paleoproteomics, birds, eggshell, aviculture, aquatic, urban, subsistence, food

Participants :
- National Institute of Anthropology and History (Mexique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
- Université de Copenhague (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ADMIRE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Key sensors for advanced and everyday technology, such as smartphones and drones, rely on inertial micro-electro-mechanical systems (MEMS). In some extreme applications they cannot yet be used, in others they cannot be substituted upon failure. Contrarily, in consumer applications they are not exploited to the end of life, in a wasteful planned obsolescence cycle. Advanced moDelling of MEMS In Routine and Extreme (ADMIRE) plans to tackle both problems by disrupting the current design practice that relies on empirical approaches based on phenomenological material properties. ADMIRE proposes a multiscale modelling framework rooted in atomistic simulations, which are cleverly extrapolated to the microscale and interpreted using Machine Learning, all to predict material degradation under a wide range of operating conditions. The result will be a new class of smart constitutive laws that will seamlessly integrate in continuum models to quantify the degradation of MEMS during prolonged use or extreme loads. A key advantage is that the effect of defects, microstructure and loads becomes transparent and mechanistic predictions become possible. Materials, engineering and computer sciences are tightly intertwined in this challenging framework. Its probability of success is maximised by reflecting the same mix in the research team and by teaming up with a world leader company in MEMS technology. Impacts will propagate to society, supporting the eco-efficient reusability paradigm, to technology, opening new applications for MEMS, to economic growth, boosting the strategic market of advanced sensors that is already on the rise, and to the leadership of Europe in this competitive field.

Mots clés : atomistic simulations, multiscale modelling, machine learning, mems

Participants :
- STMicroelectronics (Italy) (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet MaDeCyBeam (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The construction industry generates substantial waste and contributes significantly to greenhouse gas emissions. Concrete, as the primary building material, exacerbates these issues, accounting for approximately 9-10% of global CO2 emissions and a substantial portion of construction and demolition waste. To address these challenges, the utilization of recycled aggregate concrete (RAC) has emerged as a promising sustainable alternative.  However, the structural behaviour of RACs remains understudied in terms of the influence of recycled aggregate properties on structural scale behaviour. These is crucial to optimise the use of RACs and, at the same time, mitigate the risk of overly conservative design practices that could undermine sustainability benefits.  This project aims to contribute to the development of robust design guidelines for RAC elements by combining experimental testing, numerical modelling and advanced AI techniques. By identifying critical parameters influencing RAC's performance and developing robust design guidelines, I aim to accelerate the widespread adoption of sustainable concrete solutions. This project will analyse large datasets to predict structural properties including bond, dowel action, and aggregate interlock, optimize mix designs and identify potential failure modes. This research will contribute to the development of more sustainable and resilient structures while reducing the construction industry's carbon footprint.

Mots clés : recycled aggregate concrete, rac, structural behavior, ai, experimental testing, design codes, sustainability, concrete, construction, environmental impact, waste reduction

Participants :
- Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek (Pays-Bas) — Partner, associated partner, Recherche, subvention : 0.0 €
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet DEFORM (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Multi-stable composite structures are promising candidates to create adaptive/morphing structures and decrease fuel consumption for aerospace sectors. However, it seems to be a paradox to allow structures being multi-stable and stiff enough to carry loads simultaneously. Repetitive stable-mode switches also cause fatigue damage onset. To support EU aviation emission cut by 2050, DEFORM will deliver a cutting-edge design of next-generation aerospace structures exhibiting both multi-stability and high fatigue performance. Current knowledge gaps are: whether we can modify existing aerospace structures to become multi-stable; how their fatigue damage accumulates under non-linearly large deformation. DEFORM will use a three-phase interdisciplinary framework to fill in the gaps. Phase 1: Tailor non-uniform thermal stress distribution to create sequential-buckling-driven multi-stability for stiffened aerospace composite structures that can perform three stable modes under varying load amplitudes. Phase 2: Implant buckling-mode switch analysis into a virtual-crack-closure-technique-based algorithm for efficient fatigue damage modelling, providing dataset to optimise a down-scaled demonstrator with extended fatigue life and increased fatigue damage resistance. Phase 3: Perform multi-field interactive damage diagnostics in real time to measure optical-acoustic-mechanical properties at a structural level, for evaluation of fatigue damage accumulation scheme of composite structures under repetitive stable-mode switches. Overall, DEFORM will advance state-of-art of against-fatigue design, modelling and testing for multi-stable aerospace structures beyond the known limits, supporting European Green Deal for the EU’s ambition of climate neutral by 2050.

Mots clés : buckling stiffened composite structures multi stable aerospace structures fatigue

Participants :
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209483.28 €
Projet SUGER-BOL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Detecting microwave radiation, down to the single photon level, is a central challenge in modern quantum technologies. In recent years, a promising route has been envisioned, largely inspired by an ubiquitous technique in high-energy photon detection: bolometry. Its principle relies on energy dissipation of incident photons in a thermal detector, the temperature of which is monitored. This calorimetric technique allows for single photon detection in the infrared band or above, but its application to the microwave domain is challenging, since individual photons carry orders of magnitude less energy. However, superconducting nanoscale thermal detectors at millikelvin temperatures have recently shown their great potential for sensing extremely low radiation signals, as well as small instantaneous energy releases. Although still challenging at present, considering the calorimetric detection of single microwave photons emitted by a qubit is within reach. A very recent work demonstrated the single-shot read out of a qubit state, by measuring in situ the magnitude of the readout microwave signal, using a superconducting bolometer. In this project, the researcher will develop and measure nano-bolometers based on silicon-germanium heterostructures, and infer limiting factors in their sensitivity. These bolometers will be co-integrated with germanium qubits to benchmark their performances as compared to standard dispersive detection schemes. The researcher will also push these detectors' sensitivity beyond the state of the art, with the final goal to detect single microwave photons. This will allow for wide-ranging and groundbreaking applications, including alternative qubit readout schemes but also quantum thermodynamics experiments in circuit-QED architectures.

Mots clés : quantum detection, calorimetry, bolometry, josephson junction, qubit readout

Participants :
- Université Aalto (Finlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut polytechnique de Grenoble (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226420.56 €
Projet SOPHY (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

"Philosophy of Social Physics" (SOPHY) intends to explore the impact of physics on the genesis of the social sciences and to define the current use of “Social Physics” in the scientific discourse on big data related to crowd behaviors. The general hypothesis is that physical narratives and notions such as force, resistance, balance, and average have played a crucial role in shaping the concepts we use to think of society since the rise of the Sociological thought in the 19th century, and that in reconstructing the genealogy of the social sciences, the reference to natural sciences cannot be limited to the biological framework. The goal is to provide new insights into the conceptual paradigms that have been underpinning democratic governance in modern and contemporary societies, thus raising awareness about the rationale of increasingly data-based patterns in social policies. The "Social Physics" paradigm has not yet been analysed in depth through a political-philosophical perspective capable of showing the internal logic and history of the concepts employed. Additionally, an analysis of the links between physics-related notions and political and social concepts in the 19th century is still to be outlined. Moreover, there is still no historical, conceptual, and philosophical-political study focusing on the origins of social physics as it is understood and structured today. SOPHY will use a methodology resulting from an original combination of the tradition of Begriffsgeschichte, Foucauldian discourse analysis, Historical Epistemology and History of social concepts. This methodology will allow to analyse the historical semantics of concepts emphasizing their contingency and their cultural and social constructed nature, while defining at the same time the epistemic structure in which they are produced and used.

Mots clés : social physics quetelet saint simon comte sociological thought conceptual history begriffsgeschichte physics society data governance

Participants :
- École des hautes études en sciences sociales (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet ISHMAEL (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

ISHMAEL intends to explore the impact of scarcity as a pivotal concept for government choices in the genesis of political economy, and to define its current use in contemporary political-philosophical arguments on economic choices.  The general hypothesis is that the concept of scarcity and its semantics (notions such as rarity, lack, poverty) have been fundamental in shaping the social practices used by political economy as a discipline born as a science of government in the 18th century. This frame led to the establishment of a contemporary economic-political model that made inequality a systematic form of social living, as it does not focus on the regulation of resource competition or the just distribution of wealth, but on the constant vigilance in maintaining the ratio of scarcity within society, i.e. unequal access to resources (food, economic, cultural).  The aim is to shed new light on the epistemic frame underlying the political governance choices of modern democracies, thereby raising awareness about social policies based on the logic of increasing precariousness and competition for scarce resources. The framework of the concept of scarcity and its epistemic implications have not yet been thoroughly explored through a philosophical-political perspective that considers the history and logic of the development of political economy. Moreover, there is still no rigorous philosophical-political and historical conceptual study focusing on the use of scarcity as a pivotal notion in political governance and political economy as they are understood today.  ISHMAEL’s methodology will be an original interweaving of German Begriffsgeschichte, Foucauldian analysis, Critique of legal devices and Social philosophy. In so doing, it will be possible to analyse the historical semantics of the concepts at stake, highlighting their contingency and nature as social constructs, while defining the epistemic structure in which they were produced and ideologically exploited.

Mots clés : equality distributive justice scarcity governance political philosophy history of law social philosophy conceptual history begriffsgeschichte society political economy social sciences

Participants :
- École des hautes études en sciences sociales (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €