Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet YoHo (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

Consider a household looking to buy a house. In attractive locations, this household competes with other buyers to purchase their desired property since the number of listed properties is limited. In this scenario, what is the impact of subsidizing a given group? What is the impact of a change in public policy that affects one group more than others? Do households respond to the policy by changing their preferences? YoHo (Young Homeownership) builds on a simple yet powerful insight: if a buyer is competing against other buyers from the same group, then changing financial conditions for that group will not change their access to the housing market but may affect how much they can pay. The insight that YoHo proposes to formalize is that if a policy targets a large share of buyers, subsidizing them will likely not lead to higher homeownership rates but to rising prices. Moving beyond market-level outcomes, YoHo will further dig deeper into the potential side effects for young buyers, such as limited access to attractive locations. YoHo will combine Norwegian register data, natural experiments, and theoretical modeling in line with the state-of-the-art housing literature to answer questions of large importance for society, the economic situation for households, and future research into affordability and homeownership. Access to the housing market is an ongoing societal challenge in many countries that involves the general public, policymakers, and academics. The work in YoHo is at the core of this challenge, with the potential to make a meaningful contribution to the debate. The research will be conducted under Professor Florian Heider's guidance at the Leibniz Institute for Financial Research SAFE, which aims to produce original, high-quality research and research-based policy advice in all finance areas, and a regular and permanent exchange with members of governments, parliaments, central banks, and supervisory authorities in Germany and Europe.

Mots clés : homeownership, macroprudential policy

Participants :
- Leibniz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 189687.36 €
Projet PRESERT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Neuropsychiatric and neurodevelopmental disorders are a heterogeneous group of mental diseases affecting about 1 billion people worldwide. Common alterations are in the cognitive and social domains, having a critical impact on the public health, daily life, and long-term outcomes of affected patients. Unfortunately, efficient pharmacological interventions are still missing. The serotonin transporter (SERT) re-uptakes serotonin after synaptic release and is an important clinical target. SERT is widely expressed in the prefrontal cortex (PFC), an area profoundly engaged in socio-cognitive functions, and can be targeted by inhibitors -drugs acting by blocking the transporter- or by releasers- drugs acting as a substrate of SERT and then reversing its transport direction. The SERT releaser MDMA showed promising results for treating social dysfunctions in post-traumatic stress disorder and autism spectrum disorders and its pro-social effect seems dependent on SERT-reverse transport. Considering the efficacy of the SERT-releaser MDMA in modulating social dysfunctions, together with the need of SERT-reverse functions in mediating MDMA pro-social effects, and the role of the PFC in the regulation of socio-cognitive functions, the aim of PRESERT is to evaluate the impact of SERT on social cognition in mice. To achieve this overarching goal, PRESERT is divided into three specific objectives: i) investigating the impact of the PFC-expressed SERT on social cognition, ii) identifying the origin and connectivity of the underlying SERT-expressing circuits, and iii) evaluating if social cognition can be differentially modulated by the reverse transport (i.e. “efflux”) or the simple inhibition of SERT. As a direct consequence, PRESERT has the potential to link SERT, its molecular functions, and the underlying brain circuits to specific aspects of social cognition setting the ground for the development of innovative treatments for neuropsychiatric disorders.

Mots clés : serotonin transporter efflux social cognition prefrontal cortex serotonin

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 172750.08 €
Projet GRADIENT (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The main objective is to analyze the impact of dietary hypocaloric interventions based on their capacity to generate ketone bodies in different degrees of intensity: using Intermittent fasting, KetoDiet in comparison with the classical MedDiet, in individuals with obesity, and their influences on the gut microbiota, resistome, host metabolism, and the possible genetic and epigenetics links. We aim to contribute with the advance in the development of a precision medicine approach in obesity to decrease the prevalence of obesity and its associated comorbidities, and to evaluate the impact of dietary interventions as an alternative approach to antimicrobial resistance. To achieve our goal, we will study in a randomized cross-over group of individuals with obesity: A) Analyse the effect of dietary interventions (MedDiet, intermittent fasting (IF) and KetoDiet) on the gut microbiota composition and the relationship with anthropometrics, metabolic, inflammatory and epigenetics driven factors at short term (1 month) B) Analyse the effect of dietary interventions (MedDiet, IF, KetoDiet) on the gut microbiota composition and the relationship with epigenetics factors at medium-term(3 months) C) Evaluate the impact of the gut microbiota targeted dietary interventions (MedDiet, IF and KetoDiet) at short- and medium-term on the gut resistome and relate it with the inflammatory milieu of the host. Our results will help to improve the treatment of metabolic diseases associated to obesity using a precision medicine approach based on the influence of diet interventions on the gut microbiota, gut resistome, host response and environmental factors. The outcome of this project will have an impact in the health sector by improving mental health and physical health of all overweight and obese individuals, in the economy sector by reducing the need of surgical approaches to achieve weight loss, reducing the risk of development obesity-related complications and overuse of antimicrobials.

Mots clés : gut microbiota, diet, obesity, precision medicine, microbiome, resistome, metabolomics and epigenetics

Participants :
- Andalusian Public Foundation for Health Research in Biomedicine and Malaga (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet ReNiStor (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Achieving sustainability and circularity in electronics is a grand societal challenge that requires urgent action. The production of electrical components is energy intensive and puts a burden on the environment and resources. E-waste represents the world’s largest growing waste-stream and is increasing through “Internet of Things”. Microbially produced, bio-based electronics provide a promising sustainable alternative, which can be produced from renewable feedstocks and provides better biodegradation and can be extensively tuned with genetic or chemical modifications. Cable-bacteria are unique class of sediment dwelling, sulphate-oxidizing microbes, whose lifestyle has evolved entirely around long range (cm scale) conductivity. Amongst conductive materials in biology, the conductive cores in the periplasmic fibres of cable-bacteria show the highest conductivity by a wide margin and should form a primary starting point for bioelectronics design. Apart from tentative models on the fibre structure, little is known on the molecular basis and mechanism behind their conductivity, which seems to revolve around an entirely novel Ni/S cofactor. To understand the mechanism behind this remarkable biological conductivity, ReNiStor (Responsible electronics from Nickel Sulphur cofactor) aims to investigate the molecular composition of the novel cofactor, as well as it's coordination chemistry and its oxidation state. By integrating orthogonal high-end spectroscopic techniques, mass spectrometric methods and chemical imaging, the identity of the conductive molecule and its role in within the fibres will be analyzed, so that it can be subsequently produced in vitro or form a template for the design of new biomolecules. This innovation will clear the path for electronics to make the essential transition from the fossil-based to the bio-based economy, enabling radically new production and recycling pathways.

Mots clés : cable bacteria, mass spectrometry, responsible, electronics, epr, stem, eels, xanes, afm, circular, sustainable, green, conductivity, nanowire, nickel, sulphur, oxidation, reduction

Participants :
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet SPAGINTEG (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

SPAGINTEG is a two-year fellowship at the Institute for Russian and Eurasian Studies (IRES) at Uppsala University, Sweden. Russia’s invasion of Ukraine has had a dramatic aftermath beyond the battlefield. Specifically, it has resurfaced concerns about the allegiances of a large Russian-speaking population in Latvia and the pressing need for their integration into Latvian and European society. The project speaks to the gap in the studies about the everyday integration of young Russohpones in Latvia by foregrounding their agency in defining and enacting integration through their lived experiences beyond the state-centric narratives. Drawing on the critical debate in the field of minority integration and spatial studies the proposed research takes an original approach by focusing on spatial dimensions of how young minoritised Russian speakers pave their everyday trajectories through the ethnocentric geography of the Latvian society. Beyond the empirical contribution, the project contributes to the critical literature on minority integration in multiethnic societies, as well as to the policy on minority integration in Latvia and the wider post-socialist context. The main outputs of the research will include two academic articles and a policy recommendation report, which will be disseminated targeting scientific and general public, as well as the third sector. The success of the project, as well as the fellow’s further formation as an independent and prominent scholar, will be ensured through the professional guidance of colleagues at IRES in the area studies, cultural anthropology and geography, supplemented by pertinent training, teaching, and supervisory experience. The fellow will bring her interdisciplinary and innovative perspective on the area studies, rooted in the knowledge of political studies, expertise doing ethnographic research in post-Soviet contexts, as well as a critical perspective on the area studies and the minority politics in the Baltic region.

Mots clés : russian speaking minority post soviet context baltic states ethnocentrism integration

Participants :
- Université d'Uppsala (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252180.0 €
Projet SepBiEV-D (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Sepsis, the organ dysfunction triggered as a consequence of deleterious inflammatory host response to infection, has a 26% mortality rate in humans. However, there is a lack of reliable biomarkers for its accurate diagnosis. Extracellular vesicles (EVs) are small particles naturally released from the cells with promising applications in diagnosis and disease monitoring. This Project aims to evaluate salivary and serum EVs as sources of novel biomarkers in a naturally occurring model of sepsis using a multidisciplinary approach. For this, canine pyometra, a naturally occurring animal model for human sepsis, will be used. Different isolation methods for EVs and their subpopulations will be evaluated, and the most feasible will be selected. Isolated EVs will be characterized using proteomics, metabolomics, and biochemical analyses. Last, the quantity and characterization of EVs will be compared between dogs meeting sepsis criteria and those obtained from healthy individuals and animals with inflammation. This would point out different biomarkers of sepsis to be further evaluated. The results of this Project would help improve sepsis diagnostics, which can highly increase patient survival and promote adequate use of antibiotics, ultimately fighting against antimicrobial resistance. Plus, it will support using saliva as a non-invasive sample for sepsis diagnosis. Last, it is expected that the sepsis biomarkers identified in this Project could be extrapolated to other species, including humans.

Mots clés : extracellular vesicles, exosomes, microvesicles, exosomics, multiomics, animal model, saliva, non invasive samples, sepsis, infectious diseases, inflammation, diagnosis, biochemistry, biomarkers

Participants :
- Université de Murcie (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Zagreb (Croatie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187631.76 €
Projet EVOFINCH (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Rapid environmental and climatic changes threaten the world's biodiversity heritage, underscoring the importance of investigating species' adaptive potential. This task is now facilitated by the development of powerful sequencing technologies and advanced computational methods, together enabling a new wave of research into previously unattainable questions. EVOFINCH will focus on Darwin’s finches, where 18 species originated within the last million years from a common ancestor and has become one of the most iconic adaptive radiations. Due to the addition of a new closely related outgroup species to our genomic dataset and the implementation of new sequencing technologies together with cutting-edge computational methods, EVOFINCH will trace the main steps of the evolutionary history of Darwin’s finches with unprecedented resolution - from their origins to the history of their adaptation. With the support of the MSCA programme, I will first determine the phylogenetic relationship and compare long-read alignments between the new outgroup and Darwin's finches using comparative genomics and phylogenomics. Next, I will assess the severity of the bottleneck during the colonization of the Galapagos by quantifying the amount of lost genetic variability and identify mechanisms behind the recovery of such variability. Finally, I will trace the evolutionary history of the adaptive alleles underlying the key traits in Darwin’s finch evolution: their beak and body size. The project will shed new light on how evolutionary forces interplay to give rise to the observed Darwin’s finch diversity, and will enhance our understanding of species’ adaptive potential as well as their ability to recover from a population decline. EVOFINCH will be implemented at Uppsala University under the supervision of Professor Leif Andersson, and represents a springboard for the fellow to become and independent research leader in evolutionary biology.

Mots clés : darwin s finch, adaptive radiation, restoration of genetic diversity, major histocompatibility complex, ancestral recombination graph

Participants :
- Université d'Uppsala (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 236340.0 €
Projet C2RTheranostics (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Radioligand therapy has recently received renewed attention as promising treatment option to improve cancer patient outcome. Compared to conventional cancer treatments, this strategy involves a more specific targeting of therapeutic radionuclides to the tumor, which aims to increase treatment efficacy. Despite recent progress, currently available treatments show insufficient tumor killing and normal tissue toxicity, and we hypothesize that a pretargeted click-to-release (C2R) strategy can bridge this gap. Within this strategy, we propose to explore Fibroblast Activation Protein (FAP) inhibitors as tumor targeting vectors, to deliver a therapeutic radionuclide fragment intracellularly using cell permeable, cleavable transcyclooctene (dcTCO) constructs and compare it with conventional dTCOs. To reinsure intracelular release, after C2R, we designed new structures containing an RGD peptide (with integrin αvβ3 binding specificity). Our molecular constructs also aim to prevent FAP efflux, by using a guanidinium and nicotinoyl residualizing groups. This project will evaluate the reactivity, in vitro stability, logD and radiochemical yield of the new molecules, and the C2R efficiency of the dcTCOs. A FAP inhibitor (dimer) will be weaponized with a tetrazine handle to be the targeting vector and biorthogonal pair of these new constructs, and it's affinity and selectivity will be evaluated in vitro, against other proteases. The dcTCOs and dTCOs with better reaction kinetics and C2R efficiency (dcTCOs) will be selected for the development of 18F- and 125I-radiolabeled probes. The celular uptake and internalization will be evaluated on tumor cells (FAP positive cells, integrin αvβ3 positive cells, both FAP and αvβ3 positive). This project is a innovative strategy to improve the radiation dose delivered to the tumor and improving treatment outcome, while reducing radiotoxicity and achieving better treatment tolerability.

Mots clés : radiotracers, biorthogonal chemistry, click to release, theranostics

Participants :
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet MOF AlSolidBat (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Aluminium solid-state rechargeable batteries are promising candidate for post-lithium ion batteries. The electrolyte system of rechargeable aluminium batteries is an urgent research problem that is preventing its widespread implementation. The prime aim of the research proposal is electrochemical interfacial engineering of metal organic frame work (MOFs) based electrolyte towards aluminium solid-state battery applications. Study of MOFs are key topic in materials science sector over the past decade for facilitating next generation nano-electronic devices. Tuning the porosity of MOF can provide controllable functionality - an ideal platform for investigating the underlying mechanism of solid-state electrolytes (SSEs) and their ion conduction and the structure property relationships. This research proposal will address the challenges in the conventional liquid electrolytes and existing SSEs. The potential impact of the project proposal are traditional liquid electrolytes and conventional inorganic SSEs can be replaced by flexible, cost-effective and high porous MOF based SSEs for high performance and environment friendly aluminium batteries. The specific research objective of the project are,  O1. Facile synthesis of cost-effective and high-performance nanostructured MOFs  O2. Encapsulating an infinitesimal ionic liquid (IL) into MOFs to construct an IL@MOF solid electrolyte  O3. Understanding the inherent electrochemical interface and studying the underlying structure-property relationship of IL@MOF based SSEs  O4. Demonstrating a cost effective and environment friendly aluminium solid state battery with high specific power density using synthesized solid electrolyte  Research results will be published in reputed high impact open access international journals and conferences. This project is in line with the EU strategy for ‘the energy storage devices for the transition to a low carbon economy based on renewable energy source’

Mots clés : aluminum battery solid state electrolytes metal organic framework electrochemical interface ionic liquid

Participants :
- Université technique d'Ostrava (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166278.72 €
Projet RL4QStat (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

During the last two decades, Machine Learning (ML) and Artificial Intelligence (AI) tools have created a true paradigm shift and impacted numerous fields and industries. In quantum physics, ML is rapidly gaining popularity and is already being extensively used for variational quantum state representation. Recently, a more ambitious and new research direction is developing where Reinforcement Learning agents could be used to solve quantum statistical problems while improving during the task. This field is still in its infancy and is highly promising to yield efficient and scalable computational tools for physics that would be situated between semi-analytical approximations and brute-force Monte Carlo calculations. In this proposal such tools will be developed for applications in modern quantum many-body physics at finite temperatures. In particular, the goal is to train smart AI agents to sample path integrals that occur in various quantum statistical problems. Important research questions include exploring domain generalization where learned knowledge by the agent can be transferred between tasks. The developed methodology will be applied to challenging systems in condensed matter physics such as many-fermion systems and polaronic systems with memory. Besides providing powerful computational tools, this research on the thrilling synthesis of Reinforcement Learning and quantum statistics will yield new insights and perspectives at the forefront of the current AI explosion in physics.

Mots clés : reinforcement learning, path integrals, optimal control, importance sampling, statistical physics, fermions, polarons, quantum physics

Participants :
- Université de New York (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 250284.72 €