Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MARS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

SHP2 is an SH2 domain-containing protein tyrosine phosphatase with a key role in the RAS-MAPK signaling pathway. Germline mutations in PTPN11, the gene encoding SHP2, occur in 50% of individuals affected by Noonan syndrome, whereas somatic mutations in this gene cause more than 30% of cases of juvenile myelomonocytic leukemia (JMML), and are more rarely found in other hematologic malignancies and tumors. The X-ray structure of SHP2 shows a multidomain architecture compatible with an allosteric regulatory mechanism: under basal conditions SHP2 is inactive, because its N-terminal Src homology 2 (N-SH2) domain blocks the active site of the protein tyrosine phosphatase (PTP) domain. Binding of the N-SH2 domain to a phosphopeptide (PP) ligand causes SHP2 activation by favoring dissociation of the N-SH2 and PTP domains. To characterize this dynamic transition at the atomic level, will be used a combination of state of the art computational methods coupled to X-ray scattering (XS) and biochemical assays. Major goals of the proposed studies are to explain how disease-associated mutations perturb the regulatory events controlling SHP2 function, and design new molecules able to inhibit SHP2 binding to signaling partners. The project implementation is guaranteed by the expertise of the Experienced Researcher (ER) in molecular dynamics (MD) studies of allosteric mechanisms that is complemented by the consolidated expertise of the host institution (HI) in the combined use of MD and XS, together with the external collaboration of an Italian expert in SHP2 biology and a US specialist in XS. Overall, the proposed research will provide a deeper understanding of SHP2 regulation, and dissect the molecular mechanisms implicated in its functional dysregulation in human disease. The planned studies are expected to provide a new class of lead compounds to treat SHP2-associated diseases. Finally, a new computational approach for the design of peptidomimetic inhibitors will be developed.

Mots clés : molecular dynamics simulations, allosteric regulation in proteins, protein tyrosine phosphatases, genetic diseases, noonan syndrome, rasopathies

Participants :
- University of Göttingen (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 159460.8 €
Projet SINMOF (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

SINMOF is a pioneering and structured effort to comprehensively address the introduction of different immobilised isolated catalytic active sites in solid hybrid materials to overcome the metal losses occurring with state-of-the-art homogeneous catalysts employed in the pharmaceutical industry. The convenient use of hybrid metal-organic framework materials (MOFs) respect to traditional state-of-the-art porous solid materials is due to (a) self-deactivation-resistant design of the active sites by (b) ultrastable catalytic site isolation. In the SINMOF project we will (1) design novel multifunctional MOFs as next generation catalysts for the synthesis of pharmaceutically active compounds in an economically and environmentally beneficial way; (2) apply MOF hybrid solids as heterogeneous catalysts to avoid the use of homogeneous metal catalysts in novel synthetic strategies of pharmaceuticals with the indole core and finally (3) derive structure-activity and selectivity relationships at the smallest possible length scales and with the highest possible sensitivities employing fluorescence microscopy. Using a two-stage research methodology, SINMOF will finally provide the most active and stable MOF catalyst for the synthesis of the indole-based neurotransmitter Sumatriptan and the anticancerigen spirooxindole SAR405838. The combined expertise of the fellow and host ensures the best chance for successfully completing the SINMOF objectives in a mutually beneficial manner. On one side, internal collaborations at the host institution will allow the access to state-of-the-art fluorescence microscopy methods, to get new insights into the molecular mechanisms underlying the novel catalytic systems. On the other side, a secondment at a world-leading research center in the homogeneous catalysis field will train the researcher in order to individuate the best molecular features for model homogeneous catalysts to be translated into selective heterogeneous MOF catalytic system.

Mots clés : metal organic framework, heterogeneous catalysis, multifunctional catalyst, multi step organic synthesis, c h activation, hydrogen transfer, green chemistry, pharmaceutical, fluorescence microscopy

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €
Projet SMARTMEM (Horizon 2020, appel à projets 2015)
Action : Doctoral Networks - Industrial Doctorates
Panel : Chemistry
Statut du projet : CLOSED

SMARTMEM is a multidisciplinary project leveraging the emerging technology platforms around so-called smart membranes and evolving this platform to commercial use in consumer good products. The objective of this project is the training of 5 PhD students in various scientific fields around membrane technology, involving disciplines from advanced materials synthesis, to membrane production, linking product application and product performance driving new consumer value. The training will be setup in a multi sector way for the students to learn the technical depth of the disciplines as well as the innovation cycle from idea to market application and commercialisation. The objective of the project will be achieved through finding applicability in established markets like textiles with functional benefits, air care devices with health benefits and innovate beyond like develop improved microcapsules which release on demand and improved single dose detergent products, among others. Therefore, SMARTMEM will contribute to accomplish the goals of Europe 2020 strategy through: - training of highly skilful scientists in emerging fields such as stimuli-responsive materials - placing Europe at the vanguard of innovation in sustainable consumer goods by smart controlled release

Mots clés : stimuli responsive membranes and microcapsules

Participants :
- Rovira i Virgili University (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Procter & Gamble (Belgium) (Belgique) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 1252800.0 €
- CERCA Institution (Espagne) — Partner, beneficiary, Recherche, subvention : 0.0 €
Projet SOPRISEKEN (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

SOPRISEKEN focuses on the sociability of professional and managerial elites in modern Kenya. Studying socialization, and in particular the membership organizations in which it takes place, is a particularly fruitful way to understand how these elites have experienced the social and economic changes triggered in Africa by the “structural adjustment” policies of the 1980s; how they have come to understand themselves as a distinct social group - the “private sector” - sharing comparable social aspirations, lifestyle and economic ethos; and how the articulation of their interests has led to the development of similar civic and political attitudes.

Mots clés : african studies, elites, socialization, kenya

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet SSRIME (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

SSRIME investigates the entangled history of Sunni-Shii sectarianism in the Middle East by looking at the case study of Iraq under the Baath Party (1968-2003). SSRIME thus seeks to explain the root causes of instability in the Middle East, which has fuelled the refugee crisis, and thus fits key policy objectives of the European Union. It is thus not only of academic interest but has clear policy relevance. The primary research question is under what circumstances does Sunni-Shii conflict occur? SSRIME studies the relationship between the Iraqi state and the Shia, which will also allow us to draw conclusions as to the importance of the 2003 Iraq War for sectarianism. The lessons from this project can also be applied to other countries in the region, in particular to Syria under the Baath party. I will spend two years at Stanford University, most of which will be spent in the Baath Party of Iraq archives. The archives are a unique source when it comes to the modern Middle East, because they are the only publicly accessible archive of any Arab state. They are thus the best archive to study the process of sectarianisation in the modern period. Given that they are in Arabic, only accessible on site, and have not been distributed via microfilms to other institutions, they have not been used extensively yet, and have not been looked at primarily from the angle of relations between Iraq’s main religious communities. My language and research skills will allow me to use the archive to the fullest extent possible. My research project will be the first to combine extensive use of these archives with oral history and fieldwork in Iraq. During two preliminary research trips to Iraq I made important contacts that will facilitate my fieldwork. I have identified possible interviewees, some of whom I will interview outside of Iraq. The return period at Venice will allow me to bring my new skills back to Europe and focus on writing up and disseminating my research findings.

Mots clés : islam, middle east, political violence, religion, identity politics, sectarianism, sunni, shia, authoritarianism

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 251002.56 €
- Stanford University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SUPERFLOW (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

SUPERFLOW will determine the pathways and dynamics of dense water in the Nordic Seas that sustains the lower limb of the Atlantic Meridional Overturning Circulation (AMOC), which helps maintain the temperate climate of northwest Europe. The densest water supplying the AMOC stems likely from the Greenland Sea and crosses the submarine Greenland-Scotland Ridge through deep passages east and west of Iceland. While the exchange flows across the ridge have been monitored for several decades, the circulation and partitioning of the upstream flows that are co-located northeast of Iceland are not yet quantified and understood. Advancing this understanding is imperative for an accurate prediction of how the AMOC will respond to a changing climate. To identify the sources and quantify the transports of these dense-water pathways, and to understand their dynamics, a unique combination of unpublished two-year long observational time series northeast of Iceland with a high-resolution, realistic simulation from an ocean model and an idealised two-layer model will be used. The importance of this deep circulation for climate will be advertised to pupils and science-interested citizens through a coherent outreach package. SUPERFLOW will accelerate the academic career of a promising young female scientist by providing an opportunity to train scientific, outreach, and transferable skills. While the host institution is the University of Bergen (Norway), a 21-month appointment at the world-renowned Woods Hole Oceanographic Institution (WHOI) in the USA and a three-month secondment at the Marine and Freshwater Research Institute (MFRI) in Iceland are planned. This mobility is key to the success of the project, which will maintain Scandinavia’s position at the forefront of research in the North Atlantic.

Mots clés : ocean circulation, nordic seas, amoc, overflow, hydraulic control, observations, theory, modelling

Participants :
- University of Bergen (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 266345.28 €
- Woods Hole Oceanographic Institution (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet RUTE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Safely stored in archives’ storages across the world, ancient handwritten books (codices) that are too fragile to be opened, page-turned, or unfolded, are not open to consultation nor accessible, their content hidden from both experts and public. The main goal of the proposed project is to uncover their content and Reveal Unseen Text (RUTE) by reading through them without opening them. Current approaches for facilitating this task are mostly based on techniques that expose fragile manuscripts to ionizing radiation (e.g., X-ray computed tomography) potentially causing damage to ancient inks or support. To prevent damage of valuable manuscripts or written text, RUTE will exploit a non-ionizing technique, terahertz (THz) time-domain imaging, that can penetrate highly absorbing materials (e.g., paper, papyrus, or parchment) and detect paper-air gaps in the sample. Detected paper-air gaps lead to retrieving images that represent a single page of closed books often corrupted by severe system-induced blurring and noise effects. Until now, only limited attempts have been made to reduce these degradation effects (i.e., blur and noise) with none of them tailored to THz images that contain text. To fill this gap, RUTE will facilitate a unique approach to data creation and collection and introduce a highly interdisciplinary methodological process for reading through closed books. The proposed methodology will facilitate detection of paper-air gaps and pages separation, text enhancement, and document images restoration. RUTE will have a tremendous impact on analysis, preservation, and digitisation of valuable European and World cultural heritage assets by enabling the possibility to access knowledge that would otherwise remain undiscovered.

Mots clés : ancient document analysis, manuscripts, thz imaging, document image restoration, hyperspectral image restoration, image enhancement, image deblurring

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 183473.28 €
Projet BJW (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Saying that people get what they deserve and deserve what they get, can be considered as a moralizing discourse. Past research has shown that this “just world” discourse is well regarded when conveyed by ordinary citizens. The main goal of this project, however, is to show that it can backfire against those who enact it. Specifically, this programme intends to show that when financial/political elites resort to a “just world” discourse, it may lead to punishment wishes against those elites, including the use of violence. Indeed, nowadays the financial elite is stereotypically associated with white-collar crime, the consequences of which affect millions of people worldwide; and the political elite is perceived as their accomplice. It is thus hypothesized that when members of the elites, as well-intended and innocent they may be, say that people get what they deserve, they will be perceived as adding insult to injury. Compared to elite members who say that the world is unjust for people, those who say that the world is just will thus be perceived as more immoral; as a consequence, individuals will feel more moral outrage towards them and will wish them higher punishment in various domains (e.g., legal, physical, social). This is a very important issue - after the 2008 financial crisis, various European countries introduced harsh austerity measures. One strategy that political and financial elites used to legitimize these measures was to repeatedly accuse these countries, basically Southern European ones, of having lived beyond their means at the expense of the industrious Northern European. Implicit in this discourse was a collective “just world” one – those measures, as hard as they could be, were deserved. This discourse has contributed to a Northern-Southern Europe divide. This research, to be conducted by experts on justice, morality and emotions, can inform the elites about the political and personal dangers of that moralizing discourse.

Mots clés : belief in a just world, moralizing discourses, elites, perceptions of immorality, moral outrage, punishment

Participants :
- Autonomous University of Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 158121.6 €
Projet FLOURISH (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Schizophrenia risk is largely determined by genetic variation and is associated with altered development of several brain regions. Since there are likely thousands of genetic risk variants, the biology of risk and its effects on neural development cannot be determined by examining one gene at a time. Rather, it is important to understand how these genes converge into molecular pathways that determine overall risk. Genes converge into pathways because they are coordinated in response to environmental and physiologic factors. Hence, FLOURISH aims to identify biologically plausible pathways of convergence of genetic risk for schizophrenia along neural development in critical brain regions involved in schizophrenia risk. Gene Co-expression Network Analysis is effective to identify pathways of genes that are regulated, and thus expressed, together. FLOURISH will study how gene co-expression unfolds along the lifespan in the prefrontal cortex, hippocampus and striatum. Gene co-expression networks will then be associated with genetic variants to identify markers of pathway co-regulation. Genetic markers of pathways co-regulation will be combined into polygenic scores that will be tested as predictors of the structure and activity of the target brain regions assessed by magnetic resonance imaging. The action will consist of a training period (2 years) which Dr. Giulio Pergola will spend at the Lieber Institute for Brain Development (LIBD) at Johns Hopkins University, Baltimore, USA. LIBD is unique because of the unrivalled technology, expertise and research data regarding brain development. Dr. Pergola will be training about RNA analyses and return to the University of Bari Aldo Moro (UNIBA) in the final year, to validate his genetic discoveries by means of neuroimaging. UNIBA is currently setting up the largest neuroimaging center in southern Italy and plans to have Dr. Pergola build an imaging genomics team to promote personalized medicine in psychiatry.

Mots clés : gene coexpression networks, brain development

Participants :
- University of Bari Aldo Moro (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 262269.0 €
- Lieber Institute for Brain Development (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet SCIHO (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

Science Hotel is a one-week hybrid (online and onsite) festival, where the general public in Rotterdam and its region meets with scientists and is introduced in their research and its relevance for daily life. 'Humanimal', this year's theme of Science Hotel, features scientific aspects of the relation between human society and nature. Presently, this relation is relevant in dealing with the Corona/Covid-19 crisis, since the emergence of the pandemic has its origins in the animal world and public and social strategies for coping with the crisis touch upon psychosocial mechanisms originating in the evolution. Understanding the scientific aspects of this relation will help society and individuals to develop strategies for resilience. Researchers participating in Science Hotel will reflect on these aspects. The program of Science Hotel will address climate and environmental challenges with presentations of research in sustainability and transition within the context of the European Green Deal. Science Hotel facilitates personal and interactive encounters between the audience and researchers. It invites the audience to step into the daily life of researchers and discuss research topics and their perception by societal stakeholders. This dialogue is stimulated, enriched and sometimes distorted, by artists' interventions. The program kicks off during the week before European Researchers’ Night with online and offline pre-events for school classes, teachers and families. During the NIGHT itself, audiences are welcome in Science Hotel, a festival of science, art and entertainment. Science Hotel is directed to a general public with a broad interest in science, technology, innovation, art within a societal context. It especially targets a young adventurous public in the age of 19 to 39 years old; teachers, school pupils and students; families with children in the age of 15 to 21 years old; stakeholder groups of invited researchers and researchers themselves.

Mots clés : science communication, science hotel, co creation, general public, one health, green deal

Participants :
- Erasmus MC (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 75000.0 €