Projet DohART-NET (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Altered conditions during the periconceptional (PC) period of gamete maturation and early embryonic development have long lasting effects on the health of the progeny, including the childhood, adolescent and adult-life onset of cardiovascular, metabolic and neurological diseases (‘Developmental Origins of Health and Disease (DOHaD) concept). Increasing evidence from epidemiological and animal model studies shows that children worldwide exhibit conditions and disease risks associated with the exposures of their parents, including chemical stressors before and during pregnancy, reproductive failure, adverse pregnancy outcome, diabetes, obesity and nutritional compromise. Babies born following human ART (“testtube”)interventions render this population (over 5 million world-wide) one of the largest well-defined clinical cohorts to be studied for a better understanding of the future risk of disease for current and succeeding generations in Europe. The DohART-NET project focus on the integration of pre-clinical (animal and stem cell-models) and clinical studies and apply data linkage, bioinformatics and network science for the identification and validation of mechanisms of diseases common in early development. We will exploit our new understanding to promote efficient disease prevention and potential personalised therapeutic interventions in both the general and ART populations to overcome adverse disease pathways. DohART-NET is optimized for training ESRs due to the facts that: i) the topic is progressive and much needed to improve public health over several generations, and it is integrating basic pre-clinical, translational clinical and in silico modeling approaches, iii) the partnership has a highly multi- and interdisciplinary scientific and training expertise and excellence, iv) there is an existing synergy by collaborations and links that the partners wish to strengthen both in science and lasting training programs in a highly inter-sectorial setting.

Mots clés : human art, embryology, patient cohort, dohad, diabetic mother, animal models, stem cell model, epigenetics, proteomics, transcriptomics, metabolomics, bioinformatics, network science

Participants :
- Erasmus MC (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 531239.76 €
- Scipher medicine corporation (Etats-Unis) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Southampton (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
- University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 179587.53 €
- IVI Valencia Clinic (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 250904.88 €
- Marie curie alumni association (Belgique) — Partner, organization partner, Autres, subvention : 0.0 €
- Vrije Universiteit Brussel (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110146.4 €
- University of Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
- Simcyp (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Medical University of Vienna (Autriche) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Valencia (Espagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Austrian Academy of Sciences (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 84619.71 €
- Magyar Agrár- és Élettudományi Egyetem (Hongrie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Oxford (Royaume-Uni) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Ludwig-Maximilians-Universität München (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 252788.4 €
- BioTalentum (Hungary) (Hongrie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 523240.36 €
- Mwm biomodels gmbh (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 252788.4 €
- Medical women's international association (Suisse) — Partner, organization partner, Autres, subvention : 0.0 €
- Sichuan University (Chine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Manchester (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €