Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ROAR (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Acute kidney injury (AKI) is a global public health concern which results in 1.7 million deaths per year. If not lethal in the acute phase, AKI is considered reversible as suggested by recovery of renal function. However, even mild AKI episodes carry substantial risk of developing subsequent chronic kidney disease (CKD). The pathophysiological basis for this phenomenon remains unclear. Injury and death of tubular cells are recognized as the main factors in the pathogenesis of AKI and functional recovery from AKI was traditionally attributed to the regenerative capacity of tubular epithelial cells (TECs) which are believed to re-enter the cell cycle and repair the damage. Nevertheless, my preliminary data provide evidence that an endocycle-mediated response of remnant TECs may represent a critical mechanism of response to AKI. Endocycles are cell cycle variants consisting of G and S phases alone that repeatedly proceed without cytokinesis and its role in repair of mammalian tissues is mostly unknown and totally unexplored in the kidney. This proposal will be structured into 3 distinct objectives to address: 1. The physiologic relevance of endocycle for kidney function recovery after AKI 2. The role of endocycle in the progression of AKI to CKD; 3. The mechanism by which YAP1 drives endocycle and contributes to CKD development. To this end I will use lineage tracing techniques based on the FUCCI2aR reporter applied in different transgenic animal models of AKI, together with in vitro experiments in human primary cultures of renal tubular cells. Collectively, the outcomes of this proposal are expected to provide an entirely novel view of the kidney’s response to AKI, to further our understanding of the processes that drive CKD following AKI, as well as to describe for the first time endocycle as a critical response mechanism to tissue injury in the mammalian kidney.

Mots clés : acute kidney injury, chronic kidney disease, endocycle, yap1

Participants :
- University of Florence (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171473.28 €
Projet SirT-IMLEU (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Acute lymphoblastic leukemia, the most common pediatric cancer, originates in many cases from the malignant transformation of a developing Blymphocyte in the bone marrow. Understanding the mechanisms of B cell maturation and how their perturbation contributes to the onset of this pathology is essential for evolving improved strategies for those patients not responding to current therapies. Importantly, this project aims to discover novel mechanisms of B lymphopoiesis by studying the interplay between SIRT7, a Sirtuin family member critical for genome homeostasis, and PAX5, a transcription factor required for B cell development and to sustain B cell identity. Sirtuins play key roles in the maintenance of genome integrity under stress and their deficiency has been linked to the pathogenesis of cancer. Importantly, SIRT7 is highly expressed in developing lymphocytes yet their role in immune cells and its relationship with leukemia awaits further investigation. With this project, we will define SIRT7-dependent regulatory mechanisms of PAX5 protein turnover, its relationship with PAX5-associated transcriptional programs and how their functional interplay is abnormal in leukemic cells. Because PAX5 is found in haploinsufficiency in most of the cases of acute lymphoblastic leukemia of B-cell progenitors, the development of this project is highly significant to the society as it has the potential to generate novel approaches to restore PAX5 protein levels, with important implications for clinical interventions and the cure of this disease.

Mots clés : b cell development, leukemia, chromatin regulation, protein turnover, transcriptomics, sirtuin, pax5

Participants :
- Fundación Josep Carreras Contra la Leucemia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 172932.48 €
Projet HifLICs (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Acute myeloid leukemia (AML) is a heterogeneous group of diseases caused by acquired cytogenetic and molecular alterations in hematopoietic progenitor cells. There is a substantial need to develop new therapeutic approaches to AML; however, the genetic heterogeneity of AML constitutes a barrier for the development of targeted therapies. Leukemia relapse after treatment is most often caused by a subgroup of cells commonly referred to as leukemia initiating cells (LICs), which are resistant to chemotherapy. It is thought that this resistance is the result of several properties unique to LICs, including their dormant and metabolically inactive state, making them less susceptible to genotoxic drugs. The localization of the LICs in the hypoxic bone marrow niche has been proposed as a driving factor for dormancy. The HIF (hypoxia-inducible factor) family of transcription factors mediates cellular adaptation to hypoxia. While the role of HIFs in the pathogenesis of solid tumors is quite well established, they have only recently been suggested as key regulators of LICs in specific types of leukemia. Yet, results to date are highly controversial, with some studies supporting an oncogenic activity for HIFs and others pointing to a tumor suppressor role. We propose a broad transcriptional study of human AML classified by cytogenetic criteria and disease stage (diagnosis vs relapse). We will focus on HIF-regulated target genes in the LIC subgroup and evaluate LIC heterogeneity using state-of-the-art single-cell technologies. Our results should extend our understanding of the ability of LICs to survive cytotoxic therapy and help to identify candidate targets for clinical application. The use of AML patient samples and single-cell techniques included in this proposal will increase my scientific knowledge and practical experience. I will also benefit from the complementary planned activities of the action, empowering me to become an independent investigator in the near future.

Mots clés : hypoxia, leukemia, acute myeloid leukemia, leukemia stem cells, human patients, single cell analysis

Participants :
- Fundación Josep Carreras Contra la Leucemia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €
Projet TRADEOFF (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Adaptation is considered to be a fundamental determinant of organismal evolution, but getting better at something may have an evolutionary cost. This limitation is encapsulated in the concept of a trade-off, where improvements in one trait come at the expense of another. For example, pathogens that excel at surviving in their host’s absence are often worse at causing disease, and vice versa. Knowledge of how trade-offs impact pathogens is particularly important as it would enhance our ability to predict disease emergence. However, while observations of trade-offs abound, we know little about why they occur. In order to gain crucial insight into pathogen evolution, I propose to investigate the underlying selective, environmental, and genetic constraints leading to life history trade-offs in Zymoseptoria tritici, an economically important pathogen of wheat in Europe with defined infection and survival stages. We will first determine the selective constraints on adaptation by contrasting the signatures of selection on genes expressed during survival, during infection, or both, across 15 global isolates. Then, by phenotyping a diverse panel of 150 Swiss isolates, we will identify infection-survival trade-offs, and test whether or not the strength and direction of trade-offs change in response to environmental conditions anticipated under future climate change. Finally, we will evaluate the importance of genetic constraints for shaping trade-offs by identifying loci contributing to both infection and survival (i.e., pleiotropy), and will furthermore determine whether or not the mechanisms of pleiotropy are related to carbon metabolism. Identifying the causes of trade-offs in a plant pathogen will not only produce broadly relevant insights into organismal biology and ecology, but will help European scientists exploit trade-offs to sustainably manage disease and bolster food security.


Participants :
- University of Neuchâtel (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet MADDOG (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Adjoint based design optimization techniques are widely recognized as having a large potential to revolutionize the design process of modern gasturbines. By applying such techniques, the optimization of the entire gasturbine system with million degrees of freedom is within reach of the current available computational power. Such simulations include inherently all interactions between the different components avoiding sub-optimal designs. However, today’s reality is far from this prospect. Current adjoint design optimization techniques only consider aerodynamic performance, preventing the optimization of complete systems, as they are by their very nature multidisciplinary. This project will develop an adjoint optimization methodology that goes beyond only aerodynamic considerations and includes other disciplines such as structural mechanics and vibration dynamics concurrently for the first time, such that in the longer term optimization of complete systems will be achievable. The key to achieving a true multidisciplinary adjoint design optimization is to work with a master CAD geometry that is shared between all the different disciplines. This differs significantly from the current practice in adjoint techniques, which mainly considers parameterisations that are suitable for only aerodynamic optimizations. The involvement of a master CAD geometry requires the differentiation of a CAD system, until now this has not been performed as CAD systems are invariably proprietary and as such not accessible. In addition, the extension of the methodology to multiple disciplines requires for a highly skilled researcher with a background in aerodynamics as well as structural mechanics. The fellow of this proposal is a research leader at the Von Karman Institute, which has gained significant experience in the area of multidisciplinary design optimization of turbomachinery over the past 9 years and is the developer of a gradient free optimization system which includes a dedicated

Mots clés : multidisciplinary optimisation, adjoint methods, computational fluid dynamics, computational structural dynamics

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet AMaChaS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Advanced Material Characterisation System is a multidisciplinary project combining cutting-edge nano fabrication, materials growth and advanced x-ray synchrotron techniques for the investigation of materials with fundamental and technological relevance. Its aim is to provide advances both at the level of nanoscale materials preparation as well as the characterisation techniques, enabling experiments on high quality materials in a form that is not available today, pushing the nanoscale spatial resolution. First goal: To develop the know-how in nanofabrication of sample-integrated holography-masks for x-ray holography. It also provides novel ideas to perfect and refine the processes to push the technique ultimate resolution. Lens-less coherent x-ray imaging is considered as one enclosing the biggest potential suitable to investigate specimens from solid state materials for solar, batteries or spintronic technologies to applied materials such as polymers or biological matter. Second goal: The project proposes to develop a novel bottom-up path for obtaining epitaxial single crystalline membranes of ferromagnetic, ferroelectric and superconducting materials. Such process will combines ultimate clean-room processing, focused-ion beam nano-fabrication, and most advanced growth of materials by molecular beam epitaxy & pulsed laser deposition. This will enable to advance the state-of-the-art of materials for high-resolution transmission x-ray and electron microscopies, allowing studies of a broad class of relevant materials in an unprecedented high-quality form and unperturbed state. This project provides a unique opportunity to broad the knowledge and career skills of the MSCA candidate, which will coordinate and lead the efforts of the different researchers and centers involved in this synergic collaboration in the Scientific Cluster (BNC-b) and the UAB Campus of Excellence surrounding ALBA synchrotron facility.


Participants :
- ALBA Synchrotron (Spain) (Espagne) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 172932.48 €
Projet ADMIRE (Horizon 2020, appel à projets 2019)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

Advanced materials science is one of the key enabling technologies identified by the European Commission as boosting European competitiveness, creating jobs, and supporting growth. ADMIRE is an innovative postdoctoral fellowship programme providing interdisciplinary and intersectoral training in strategic priority areas of advanced materials research, aligned with the strengths of AMBER: SFI Research Centre for Advanced Materials and BioEngineering Research. The aim of ADMIRE is train the next generation of research leaders in Europe in advanced materials science. A rigorous training programme will equip the fellows with the skills and flexibility to develop independent careers in their field of research in academia or industry. The ADMIRE programme will fund 12 two-year incoming fellowships in Ireland in the area of advanced materials, with fellows being recruited through 2 calls for proposals over the 60 month duration of the project. AMBER/TCD will contribute €1.19M to support the implementation of the programme, and will ensure that a fair, transparent, open and merit based recruitment process is implemented in the 2 calls. ADMIRE fellows will be based in one of the 8 academic partners of AMBER, and they will have access to the full range of AMBER state of the art facilities and expertise at these locations. Principal investigators across the academic partners will supervise, host and train fellows. Industry partners will host fellows during secondment periods and will contribute to industry relevant training in the ADMIRE programme. Fellows will have complete freedom of choice in their supervisor, host institution and research topic, provided it aligns with the existing research priorities within AMBER. ADMIRE is an exciting new strategic endeavour which will contribute to AMBERs core mission of generating world-class materials innovations and translating these into impact communities nationally and internationally.

Mots clés : advanced materials research, bioengineering, interdisciplinary training, postdoctoral, materials for health, 2d materials, material synthesis and characterisation, biomaterials, intersectoral

Participants :
- Trinity College Dublin (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 882720.0 €
Projet SAAERO (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Aerosolized particulate matter (PM), suspended in the atmosphere, particularly its fine fraction, has well documented detrimental effects on air quality, human health and ecosystems. Every winter, the Western Balkan (WB) region is experiencing some of the poorest European and global air quality, due to the extensive use of solid fuels for domestic heating and an old vehicle fleet. Countries of the WB lack state-of-the-art atmospheric scientific research despite high levels of ambient pollution. It is imperative to understand the sources and mechanisms governing such air pollution. The SAAERO project proposes setting-up the first systematic extended measurements of fine aerosol in the city of Sarajevo, Bosnia and Herzegovina, to deliver detailed aerosol physico-chemical characterization and quantify their effects. During six months, measurements will be performed with on-line, high time resolution (total, organic and elemental carbon, and black carbon) instrument and daily, continuous filter samples will be collected for off-line laboratory analyses. Additionally, during an intensive two week field campaign, aerosol chemical composition will be measured with state-of-the-art aerosol mass spectrometer on board a mobile research laboratory. Subsequent off-line analyses of aerosol filter samples will give detailed aerosol chemical composition from bulk to source-specific organic marker species, and the sample oxidative potential, which will be used as a health effects proxy. Finally, sophisticated source apportionment methodology will be used to deduce PM emission sources, atmospheric processing of emissions. A novel methodology linking aerosol fractions and oxidative potential will be developed to assign health effects to specific sources. The proposed SAAERO project aims for a strong and lasting impact in understanding and resolving current major environmental and health crises in the entire WB region, establishing a solid baseline for the abatement intervention.

Mots clés : urban air pollution, atmospheric aerosol, source apportionment, health effects, sarajevo, bosnia and herzegovina

Participants :
- University of Nova Gorica (Slovénie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 150040.32 €
Projet EVENTS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Affective experiences resulting from specific work-events are present everywhere in daily work. Its importance has been highlighted for both managers and researchers. However, research into the understanding of how contextual factors, such as job characteristics or management practices, influence work-related daily events, which in turn, affect individual performance and well-being has been narrow, incomplete, and problematic. This project aims to explore the relationships between new characteristics of the work context, daily events at work, performance management practices and other outcomes in a longitudinal approach. Accordingly, this project focuses on: (a) the work characteristics associated to workrelated daily events, over time; (b) the relationship between daily events and performance and health, over time; d) the influence of high performance management practices on those relationships. By addressing the relationship between contextual factors with work-related daily events at work over time, this project makes important contributions to theory development within the field. The findings may help managers to understand how daily events influences employees’ performance and well-being. Moreover, it will help to produce practical instruments and to develop strategies to deal with daily events that may improve productivity and quality of life at work.

Mots clés : work related affective events, performance management practices, job design, changes in the nature of, work, job characteristics, performance, well being, health, longitudinal methods

Participants :
- University of Barcelona (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet BIOCONTROL-A (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Aflatoxins (AF), the most toxic and carcinogenic compounds among the mycotoxins, are mainly produced by the fungi Aspergillus flavus and A. parasiticus. Because these fungi are common soil residents of almond and pistachio orchards, these nuts are one of the main sources of human exposure to AF. The consumption of almond and pistachio has increased in recent years in the European Union (EU) due to their positive effects on the consumers’ health. Spain has the largest area (587.000 ha) under almond cultivation after USA and its pistachio growing-area is exponentially expanding. Contaminated batches of Spanish nuts by AFs have been frequently detected. Application of atoxigenic strains of A. flavus has successfully reduced crop AF-contamination in the USA and Africa. This biological control strategy uses endemic atoxigenic A. flavus strains, considered best adapted, to displace the AF-producing fungi. Unfortunately, EU farmers do not have the benefit of this type of biological control technology since there are not registered atoxigenic strains in this area. The aim of current project is to: i) improve substrate and application methods of atoxigenic A. flavus; ii) select new biological control agents for their patent and future registration in EU and USA; and iii) construct mechanistic models of risk for AF-contamination. The expected results will have a positive impact improving food safety and the environment and securing economic benefits to EU farmers and agri-food industries. In addition, this project supports capacity building, provides the foundation to the fellow in pursuing his independent scientific career and strengthens collaboration with research groups from EU and USA, three small-medium enterprises (SEMs), and a spin-off company.

Mots clés : aspergillus flavus, aflatoxin, biological control, plant disease epidemiology, biological control agent

Participants :
- University of Córdoba (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 235674.9 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €