Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MigRural (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Although emigration of Portuguese gains importance in the public opinion and political discourses, as shown by press releases and political declarations the past years, within the Portuguese academic context, emigration and return have been marginal objects of study. This project addresses one of the mobility patterns affecting Portugal: the return of Portuguese immigrants who reside or resided in France to rural regions of the country. Within this context, it aims at critically examining the economic, social and political impacts of return mobilities in rural decayed areas, and comparing the current situation to works produced in Portugal in the 1980s and early 1990s. It also interrogates the role of this immigration within a wider range of mobilities that affect rural localities. More generally, MigRural participates in the better understanding of return mobilities on the one hand; and rural localities on the other hand; as well as the intersection between immigration and production of places. It can therefore offer rich insights on the inclusion of returnees and their participation in the revitalisation of rural former ‘exodus’ areas. In fact, return migration can be seen as a “force for change in rural society” (Black, 1993).

Mots clés : return migration, return mobilities, rural, periphery, place, home making, homing, immigrant integration, local policy

Participants :
- University of Lisbon (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160635.6 €
Projet ISOMAXENT (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Although from an historical point of view Computer Aided Design (CAD) and Numerical Analysis have always been two detached engineering disciplines, a lot of effort has been made over the last few years to seek a tighter integration between them. The recent development of Isogeometric Analysis (IGA) was one of the main achievement in this direction. The key idea of IGA is to use for the Analysis the same basis functions employed for the CAD representation, which in most of the cases are non-uniform rational B-splines (NURBS). However, the tensor product nature of NURBS poses some limitations in the trivariate volume parametrization of complex shapes and in local refinement, operations that are not needed for CAD purposes but are particularly important for the Analysis. This project aims at developing a coupled approach where IGA is blended with the Maximum Entropy meshless approximants, in order to overcome to such limitations, which prevents IGA to fully develop outside of the academic world into industry, and thus to create a design-through-analysis methodology with many potential industrial applications. Such methodology will be first developed for three-dimensional applications in the framework of NURBS boundary representations and then alternative frameworks, based on T-splines and subdivision surfaces, will be also explored. The application of the method to practical problems of industrial relevance will be then considered in detail. The programme will boost the career prospects, increase employability and widen the set of skills of the experienced researcher.

Mots clés : isogeometric analysis, meshess methods, maximum entropy, design through analysis, computer aided engineering, computer aided design

Participants :
- Universitat Politècnica de Catalunya (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 158121.6 €
Projet WORLD (Horizon 2020, appel à projets 2019)
Action : Staff Exchanges
Panel : Economic Sciences
Statut du projet : SIGNED

Although several Countries have enacted specific legislations in order to boost the recycling of used vegetable oils, the limits of the current technology don’t allow a proper reutilization of such raw material. The project WORLD aims to develop a virtuous green process for WCOs recycling which applying a circular economy model. An innovative fast and zero-waste production of biolubricants from WCOs will be developed employing green and recyclable raw materials (water and natural bentonites). The wastewaters and the contaminated bentonites will be recycled in two independent sub-processes. In addition to the biolubricants production, the possibility to obtain a suitable medium for VOCs treatment from WCOs will be considered. The scientific part of the project will be developed in agreement to the economic guidelines defined by UBU-ICCRAM. In fact, in order to develop a circular economy model and to produce refined products competitive on the global market, a detailed business plan will be edited. The recycling of the raw materials, the minimization of Critical Raw Materials (CRMs) and reduction of the production costs with respect to existing processes, will be exploited for build the economic plan. The Company GESTTA will guarantee assistance in the scale-up step will facilitate the brake into the market of the refined products. Life Cycle Assessment studies (LCA) and market analyses performed by UBU-ICCRAM will enhance the market competitiveness of the proposed process. The optimized transfer of know-how and skills within the Staff members involved from the academic and private sectors, as well as the best strategies of value chain analysis, scaling-up analysis and financial requirements analysis, during all the duration of the project will be guaranteed by the contribution to the project of FYD, an Italian Company specialized in transfer of knowledge activities.

Mots clés : business plan, business model, circular economy, market analysis, scaling up analysis, revenue model, value chain analysis

Participants :
- Politecnico di Milano (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 101200.0 €
- Université Djillali Liabes (Algérie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Find your doctor srl (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 78200.0 €
- University of Burgos (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 78200.0 €
- Gestta medio ambiental sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 78200.0 €
- Université du Littoral Côte d’Opale (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 41400.0 €
- University of Sassari (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 82800.0 €
Projet FeedbackTeamContest (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : CLOSED

Although the effect of feedback on performance in individual competitions is analyzed both theoretically and experimentally, there are only few studies analyzing the effect of feedback on team performance in team competitions. The purpose of this research project is to understand the role of feedback in team competitions in various environments. There will be two parts in the project. In the first part, the effect of feedback on performance in individual and team competitions will be compared (both endogenously and exogenously formed teams will be considered). In this part, there will be just one task and team performance will be the sum of team members’ efforts. In the second part of the project, the effect of feedback will be analyzed in an environment where two complementary tasks will be assigned to team members. In this case, the amount of complementarity will be the free parameter and how agents choose their teammates (endogenously or exogenously) will be varied. Both projects will be experimental studies. In addition to the significant contribution to the literature, the project plans to contribute to workplace-innovation policy of Europe, which aims at “… improving staff motivation, thereby enhancing labor productivity, organizational performance, innovation capability, and consequently business competitiveness”. The project will contribute to this objective by finding out the most stimulating tournament environment for workers.

Mots clés : experimental economics, contests, comparative advantage, team formation

Participants :
- Middle East Technical University (Turquie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 157845.6 €
Projet FiBRO (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Although the therapeutic strategies adopted in the last years for the clinical management of patients with rectal cancer have improved patient’s quality of life, tumor relapse still constitutes to be a factor that determines patient survival. These patients, usually treated with chemo-radiotherapy (CRT), often develop a CRT-induced fibrosis, which is characterized by an overgrowth of fibroblasts at tumor-treated areas. The importance of tumor stroma for the development, progression and invasion of cancer is increasingly gaining weight, however, the biological basis of fibrosis, as well as the consequences that it has in terms of therapy resistance and tumor relapse remain unknown. The major objective of this proposal is to understand the effect of CRT on fibroblasts and its consequences on tumor relapse and formation of distant metastasis. To reach this, we propose a multidisciplinary approach that combines the analysis of unique patient-derived biological samples using innovative and advanced techniques in molecular and cell biology. More specifically, using a proteomic approach and primary cultures of fibroblasts derived from rectal tumors taken before and after CRT from the same patient, we will determine the effect of CRT on the molecular alterations in fibroblasts. Then, using 3D in vitro models we will determine if CRT-derived fibroblasts play a role in therapy resistance, proliferation and invasion of cancer cells, while ortothopic mouse models will be used to test if CRT-derived fibroblasts can trigger rectal cancer progression and metastasis. Finally, using previously collected clinical data of rectal cancer patients we will analyze if tumor relapse is related to the appearance of fibrosis and, if it has a positive or negative prognosis value Altogether, the results expected from this project will improve basic biological knowledge of fibrosis-development, and will provide with new clinical tools to improve patient welfare.

Mots clés : cancer microenvironment, cancer associated fibroblasts, fibrosis, recurrence, metastasis

Participants :
- Institut Curie (France) — Coordinator, beneficiary, Recherche, subvention : 173076.0 €
Projet ActIng (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Although the value of the olfactory systems of animals, and particularly insects, for detecting key marker chemicals associated with anthropogenic problems has been explored, this training program will study a totally new approach. The objective is to study the possibility of inducing a positive association between an originally aversive marker chemical and an addicting reward in the German cockroach B. germanica through associative learning processes. The German cockroach has been chosen as model insect for its particular evolutionary and physiological features. The challenges of the present proposal are to understand how addiction shape adaptive control mechanisms and how induced drug addiction affects the behaviour of individuals and groups in the recognition of olfactory stimuli. The innovative idea is to induce flexibility in the behaviour of the model insect, reassessing the motivation priorities in order to be able to manipulate the behavioural responses of the insect. Defining and understanding the reactions of insects to different environmental stimuli associated with addiction inducing chemicals could open new technological insights in the use of insects for beneficial purposes and will generate new keys of interpretation of insect brain physiology. This project will also impact the society at large with a new concept of applied entomology under three main aspects. Under the industrial point of view, the use of addicted insects will open new areas for development of biosensors and bioelectronics; under the humanitarian point of view, the achievement of the training will open new possibilities for the use of insects for beneficial purposes and third this project will offer a different and unexpected view of the science of entomology which is most often intended as related exclusively to agriculture or to human health.

Mots clés : ethology, behaviour, neuroethology, insect physiology, drug addiction

Participants :
- UK Research and Innovation (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 195454.8 €
Projet ChildPro (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Although there is no scholarly agreement on how to define “giftedness”, there is a consensus on why it is important: understanding giftedness, and especially, gifted children, means understanding human potential and development. Conceptions of giftedness affect education and parenting, and can create unrealistic expectations in adults and children. Child prodigies manifest an extreme form of giftedness. Research on giftedness is chiefly developed within psychology, and remains quite ahistorical. Meanwhile, historical research on prodigies focused on case studies, failing to account for today’s interest in gifted children. This project aims to go beyond these two approaches. It will explore how the history of child prodigies can help to explain the current fascination with giftedness. To do so, it will examine child prodigies in cultural and scientific settings (such as the theatre and the laboratory) in 19th and early 20th century France, mainly Paris. The project will address child prodigies as a cultural phenomenon that: a) influenced the western scientific interest in giftedness, and b) built a long-lasting entertainment culture around gifted children. The study will build upon past and current psychological research on giftedness, and contribute to fields such as the history of science, and childhood and celebrity studies. With my postdoctoral experience in an ERC project, and with a promising track record, I am prepared to move a step further. The MSCA will help me improve my skills in teaching and project management. In addition, I will be able to provide a historical background to a socially sensitive and timely topic. Overall, it will solidify my career, preparing me to apply for funding and academic positions to reach independence.

Mots clés : history of psychology, child prodigies, giftedness, celebrity studies, history of childhood, childhood studies

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 173076.0 €
Projet EXOSOMES_AD (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Alzheimer’s disease (AD) is the leading cause of dementia worldwide (>30 million people). The cause of the disease is not known, and there is no causal treatment. Extracellular vesicles (EVs), including exosomes and microvesicles, are structures released by most if not all cells. EVs carry competent signalling proteins, lipids and nucleic acids, participating in cell-to-cell communication. Recently, EVs emerged as relevant actors in neurodegenerative diseases, especially in AD, and they were described as biomarkers in patient’s fluids. Interestingly, they seem to have a dual role in AD: spreading of pathological aggregates, and neuroprotection against the progression of the pathology. In this project, I will describe in detail the EVs biology in AD elucidating how they act neuroprotective. I will characterise the composition, source and uptake mechanisms of EVs throughout AD progression. I will extract EVs from brains of AD patients (sporadic and familial) and age/sex-matched controls in two stages of the disease. RNA and protein profile will be characterised by novel RNA sequencing and mass spectrometry technics. From these omics analysis, protein and gene candidates related to the EVs functions in AD will emerge. Moreover, to investigate putative mechanisms of neuroprotection in AD, I will treat neural cultures from hiPSCs with AD-derived EVs and stress them with AD-like inputs. The effects of these treatments will be assessed by advanced analysis (i.e. Ca2+ imaging, and mitochondrial trafficking analysis). The endocytic pathways and surface proteins involved in EVs’ uptake will also be evaluated. Finally, AD-iPSC cultures will be used to functionally modify the targets obtained from the omics analysis to foster their neuroprotective role in AD. My project will generate mechanistic insight in EVs’ neuroprotection in AD by combing the deep phenotyping of patient-derived EVs with hypothesis-driven experiments in hiPSC to open the door to new EV-based AD treatment.

Mots clés : alzheimer s disease, exosomes, extracellular vesicles, transcriptomics, proteomics, neuroprotection, ipsc

Participants :
- Universität Hamburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 244209.6 €
Projet Popmask (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Among top ten current N95 producers, only one of them is EU-origin company. Europe needs to act to develop sustainable face masks to lead the fabric filtration industry, which will be worth in excess of 2.7 billion Euros in 2024. Due to ongoing coronavirus pandemic, consuming billions of face masks around the globe resulted not only plastic pollution, but also created a shortage on the melt-blown polypropylene (PP) supply chain, which is the mainly used filtering medium. PP is a petroleum-based polymer and doesn’t have antibacterial activity. The ideal solution to this problem would be using a sustainable and antibacterial filtration media that can effectively filter ultra-small particles such as coronavirus itself. To address the challenge, I have formulated an innovative and interdisciplinary project based on my research experience to develop filtration media using sustainable and antibacterial poplar fibers that aligns with The European Green Deal action plan. After developing poplar webs, I will utilize Grado Zero Espace's (GZE), expertise to create commercial surgical masks and filtering facepiece respirators (FFP). The significance of developing Coronavirus-specific project is clearly emphasized in the European Research Area Corona Platform. Developing surgical masks and FFPs prototypes from a sustainable material not only contributes Sustainable Development Goal of EU, but also could lead higher-added value products, responding the global need for face masks in pandemic situations.

Mots clés : fibre science, fiber science, textiles, nonwovens, textile technology, sustainable fibers

Participants :
- Grado Zero Espace (Italy) (Italie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 183473.28 €
Projet BBLOCK (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Amongst all natural products, polyketides constitute a very important class due to their broad spectrum of biological activities (eg. antibiotic, antitumoral, antifungal, antiparasitic). Many of these compounds are referred to as polypropionates, which are characterized by sequences of methyl- and hydroxy-bearing stereogenic centres, enabling large numbers of possible stereochemical permutations. The importance of these natural products as therapeutic agents and as biomedical tools together with their structural complexity has made these molecules attractive targets for synthetic organic chemistry. The key to construct these systems, which posses a high level of stereochemical information, is the control of the absolute and relative stereochemistry of each centre. Herein we propose the development of a novel and general strategy for the synthesis of any polypropionate-like molecule based on the construction of a building block assembly platform. This process will capitalize on the well-established lithiation-borylation methodology so complete control of both relative and absolute stereochemistry of all chiral centres will be achieved. The power of the strategy will be demonstrated in the synthesis of the polypropionate core of the antibiotic Streptovaricin U. The successful development of this research will shortcut the synthesis of stereochemically defined polypropionates combining building blocks of varying length. Moreover, the possibility to modify the stereochemistry of any centre will allow access to all known natural polypropionate fragments and will permit the preparation of non-natural analogues too. The development of such an ambitious and innovative project in the University of Bristol will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my career development following the training plan envisioned.

Mots clés : polypropionate, asymmetric synthesis, lithiation borylation

Participants :
- University of Bristol (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €