Projet LongTREC (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Thrid-generation, single-molecule long-read sequencing technologies such as Nanopore and Pacbio are revolutionizing transcriptome research and are expected to outcompete short-reads sequencing for gene expression studies. However, technical and bioinformatics challenges exist to the realization of this full potential. In this project, we will train a team of excellent Doctoral Candidates to become the European and world leaders in the field of long reads transcriptome sequencing (lrRNA-seq). The team will address three fundamental aspects of current barriers to the progress that these technologies face. a) Obtaining high-quality sequencing and preprocessed data from improved library preparation protocols and bioinformatics preprocessing methods, b) Establishment of benchmarked analysis pipelines for the application of these approaches to genome annotation and isoform usage analysis both in bulk and single-cell samples, and c) Extension of long reads to multi-omics applications for the study of regulatory biology. Additionally, DC will follow an intensive and comprehensive training program composed of scientific and soft skills training, including activities related to pressing societal challenges such as climate change, diversity and inclusion, and the ethics of science. Students will complement their education through secondments in top European laboratories and Companies as well as through exposure to a network of worldwide experts in the field of RNA research.


Participants :
- Université Paris-Saclay (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Wobble genomics limited (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Institut national de Biologie (Slovénie) — Partner, beneficiary, Recherche, subvention : 242179.2 €
- Université polytechnique de Catalogne (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Stichting global organisation for bioinformatics learning, education and training (Pays-Bas) — Partner, associated partner, Autres, subvention : 0.0 €
- SB Science Management (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Earlham Institute (Royaume-Uni) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université Pompeu Fabra (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Commissariat à l’énergie atomique et aux énergies alternatives (France) — Partner, beneficiary, Recherche, subvention : 282693.6 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 251971.2 €
- Biobam bioinformatics sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 251971.2 €
- Centro de Regulación Genómica (Espagne) — Partner, beneficiary, Recherche, subvention : 503942.4 €
- Université Cornell (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 282693.6 €
- Ecole doctorale internationale Jožef Stefan (Slovénie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, beneficiary, Recherche, subvention : 260539.2 €
- University School for Advanced Studies - IUSS Pavia (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Italian Institute of Technology (Italie) — Partner, beneficiary, Recherche, subvention : 252231.0 €
- Université de Nottingham (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Stockholm (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 293709.6 €
- Université de Valence (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- State University System of Florida (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Côte d'Azur (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'East Anglia (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Uppsala (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Oxford Nanopore Technologies (United Kingdom) (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université libre de Berlin (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €