Projet ReWire (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

ReWIRE will combine innovative translational neurotechnologies and rehabilitation interventions for the repair and restoration of neurological functions following injury of the spinal cord (SC). The proposed research program will equip next-generation scientists with unique skills to develop disruptive therapeutic solutions for patients with paralysis. Recent technological breakthroughs have triggered a paradigm shift in the conception of therapies aimed to restore function after spinal cord injury (SCI). Novel drug delivery systems and biomaterial bridges have been engineered to reduce secondary injury and scarring, to stimulate and guide regenerating nerve fibres across the lesion site, and to promote functional reconnection with intact tissue. Additionally, neuromodulation therapies can reactivate spinal circuits below a SCI, allowing people with chronic paralysis to regain voluntary control of walking. In conjunction with rehabilitation, neurological recovery was promoted that persisted without neuromodulation, suggesting a rewiring of the SC as demonstrated in preclinical models. To bypass an injury, neuromodulation has been linked to brain signals to re-establish cortical control over spinal circuits by employing electrical nerve stimulation and robotic systems. Advances in robotics are significantly augmenting the impact of neurorehabilitation by inducing new natural “wired” connections. The aim of ReWIRE is to leverage all these technical and therapeutic breakthroughs in the framework of multiple PhD projects that will continuously interact to converge toward effective combinatorial treatments for SCI. ReWIRE will focus on three inter-woven objectives: i) establish an international, interdisciplinary, and intersectoral educational network, ii) build an SCI clinical data platform, and, iii) position Europe at the forefront of therapy for SCI.

Mots clés : spinal cord injury, comprehensive therapies, personalized therapies, combinatorial therapies, biomaterials, gene therapy, rehabilitation, neuroprosthetics, robotics, wearable sensors

Participants :
- Wearable robotics s.r.l. (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 259437.6 €
- University Hospital Aachen (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École polytechnique fédérale de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université technique de Rhénanie-Westphalie à Aix-la-Chapelle (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de la Colombie-Britannique (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École supérieure Sainte-Anne de Pise (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 259437.6 €
- Université Johannes-Gutenberg de Mayence (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Aachen proteineers gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Commissariat à l’énergie atomique et aux énergies alternatives (France) — Partner, beneficiary, Recherche, subvention : 282693.6 €
- Centre Hospitalier Universitaire Vaudois (Suisse) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université de technologie d'Eindhoven (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274370.4 €
- Académie royale néerlandaise des arts et des sciences (Pays-Bas) — Partner, associated partner, Recherche, subvention : 0.0 €
- German Center for Neurodegenerative Diseases (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Imperial College London (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Myoswiss ag (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of California System (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Leibniz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 781617.6 €
- Onward medical nv (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 274370.4 €
- Pepscan (Netherlands) (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 274370.4 €
- Université de Londres (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de technologie de Hambourg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 260539.2 €
- Creoptix ag (Suisse) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €