Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet PAIMI (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Polaritonic chemistry is a new field of research bridging chemistry with quantum optics. It has been shown that confining molecules into microscale optical cavities can lead to the formation of polaritons, hybrid light-matter states offering a unique way to design and control chemical processes at the molecular level. The formation of polaritons can influence molecular structure, chemical reactivity and intermolecular interactions, and result in controlling chemical transformations, energy transfer, and internal motions of molecules. In the last five years it has been shown experimentally that polaritons in microfluidic infrared cavities can change the kinetics and thermodynamics of thermally activated chemical reactions. Despite much effort, theory is not yet able to provide a full understanding of these results. In addition to chemical reactions, the spectroscopy of molecular polaritons is also of high interest. The central questions we are looking to find answers to include a) How does the interaction with infrared cavity radiation manifest in the properties of rovibrational states of complex (multi)molecular systems? b) How does resonant light-matter interaction between the cavity modes and the molecules influence the interaction and coupling among the various degrees of freedom in weakly bound molecular complexes? c) What new phenomena can be learned from the collective polaritonic states simulated using realistic molecular models and/or large number of molecules? This project aims to extend the field of (ro)vibrational polaritonic chemistry by (a) delivering high-accuracy theoretical models and related computational tools capable of treating medium sized (floppy) molecular systems in an IR cavity, (b) revealing the characteristic phenomena which occur when weakly bound molecular complexes interact with IR cavity radiation, (c) extending simulations to the collective states of large number of molecules by exploiting massively parallel code implementation.

Mots clés : polaritonic chemistry, vibrational strong coupling, weakly bound molecular complexes, massively parallelized implementations

Participants :
- Université Loránd Eötvös (Hongrie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 182743.92 €
Projet P2XSACat (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

High efficient Power-to-X technologies such as hydrogen production by water splitting, the electrocatalytic reduction reaction of carbon dioxide to fuels, and nitrogen reduction to ammonia are the cornerstones for building sustainable future energy and economy. P2X technologies are a direct tool for achieving carbon neutrality and reducing the negative effects of anthropogenic climate change, as well as, dramatically reducing the role of fossil fuels in energy and industry, making it impossible to use the fossil fuels supply as an instrument of political pressure. The Proposed project is aimed at the development and complex study of the electro- and photo-electro active materials based on single-atom-modified 2D flakes of MXenes and MBenes, aimed at significant improvement of the energy efficiency of Power-to-X technologies. Optimization of the composition and structure of catalytic sites, including the simultaneous decoration of material by two or several atoms of different elements, controlled by electrochemical atomic-force spectroscopy will be used for the preparation of efficient catalytic materials with outstanding properties. Novel methods of decorating 2D materials by laser and microwave exposure, as well as, general patterns of controlling the catalytic MXenes and MBenes activity by SA (SA ensemble) structure will be also developed.

Mots clés : mxene, mbene, single atom site, carbon dioxide reduction reaction, nitrogen reduction reaction, oxygen reduction reaction

Participants :
- Institut de technologie chimique de Prague (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 166278.72 €
Projet POLAR (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The opportunistic fungus Aspergillus fumigatus is an emerging cause of life-threatening respiratory infections in an expanding group of patients with acquired innate immune defects. Dissecting the molecular dynamics of fungal-host interplay mediating sterilizing immunity against A. fumigatus is crucial to gain insight in disease pathogenesis and develop novel immunomodulatory therapies. Physiologically, Aspergillus fumigatus conidia are eliminated inside Alveolar Macrophages (AMs) via activation of the LC3 associated phagocytosis (LAP) pathway. A. fumigatus cell wall melanin blocks LAP to promote pathogenicity. Intracellular germination of A. fumigatus conidia results in exposure of immunostimulatory fungal molecules concomitantly with melanin removal and triggers NADPH oxidase-dependent activation of LAP. The molecular mechanism of LC3 conjugation on A. fumigatus phagosome membrane and the physiological function of LAP on AM biology and antifungal host defense remain elusive. Of interest, pilot studies in the host lab demonstrate that infection of AMs and other types of macrophages with live conidia of A. fumigatus results in a unique pattern of pulsatile LC3 recruitment on the phagosome membrane, which is accompanied by waves of increased phagosome permeability. These findings imply for a novel mechanism of LC3+ phagosome (LAPosome) formation via cytosolic sensing of fungal vita-PAMPs and suggests for an unconventional function of LAPosomes in regulation of membrane repair mechanisms in response to damage induced by Aspergillus infection. This research project aims to understand the precise host and pathogen molecular determinants of LAPosome formation and exploit the intriguing role of LC3 on regulation of phagosomal membrane repair during A. fumigatus infection. Using A. fumigatus as a model pathogen, this project with provide fundamental insights on the role of LAP in macrophage biology paving the way for new host-directed strategies.

Mots clés : fungal immunity, non canonical autophagy

Participants :
- Foundation for Research and Technology Hellas (Grèce) — Coordinator, beneficiary, Recherche, subvention : 153486.72 €
Projet Phenoevo (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Understanding the mechanisms that generate phenotypic variation and their impact on evolutionary processes is central in modern biology. When faced with adverse environmental conditions populations survive through two distinct processes: phenotypic plasticity (i.e. mechanism in which one genotype produces several different phenotypes depending on the environment) or evolutionary adaptation (i.e. pertinent allele frequency changes in population). While numerous studies have expanded our knowledge of evolutionary principles, the molecular basis and the relative contribution of these two processes to the adaptation is still unknown. Here I propose to tackle this key question by performing experimental evolution and exposing wild-caught D.melanogaster populations to four temperature selection regimes: constant cold temperature, constant hot temperature, fluctuating between hot and cold and optimal temperature as a control. To determine the genetic targets of selection behind the change in thermal tolerance I will perform pooled whole population sequencing of both ancestral and evolved populations. The alleles that increase in frequencies between the ancestral and evolved populations will be further validated to determine their effect on the thermal tolerance. To understand the contribution of phenotypic plasticity to the process of adaptation, I will transfer the evolved populations into a non-selective environment and determine the relative change in thermal tolerance that occurred upon the transfer. Furthermore, to unravel the gene regulatory changes associated with plastic response, I will perform ATAC-seq (chromatin accessibility assay) and RNA-seq (changes in gene expression) of evolved individuals before and after the transfer to the non-selective environment. The inclusion of epigenomic and transcriptomic analysis of the evolved populations will enable us to construct a more holistic picture of adaptation.

Mots clés : thermal adaptation experimental evolution phenotypic plasticity gene reglation

Participants :
- Fciencias.id - associacao para a investigacao e desenvolvimento de ciencias (Portugal) — Coordinator, beneficiary, Recherche, subvention : 156778.56 €
Projet FIAS-FP (Horizon Europe, appel à projets 2024)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

The French Institutes for Advanced Study (FIAS) Fellowship Programme strengthens high-level scholarship and international mobility in the European Research Area by upgrading the offering of scientific residencies to experienced researchers in the Social Sciences and the Humanities (SSH) and in other sciences interfacing with them. The Institutes for Advanced Study (IAS)—located in Cergy, Lyon, Marseille, Montpellier, Nantes, Orléans-Tours, and Paris—form a large scientific consortium that proposes a unified entry point in France to seven first-class research, training and networking residencies. The 112 fellowships to be offered will provide experienced scholars worldwide with the opportunity to spend 10 months in leading scientific, economic and cultural regions in Europe.  FIAS supports individual professional development as fellows benefit from unsegmented time to conduct bottom-up research with the greatest freedom and enjoy outstanding material and intellectual conditions. Thanks to the IAS’ scientific and extra-academic support, the FIAS experience brings fellows to the next level of excellence and generates a significant boost to their careers: 1. It enables fellows to produce important work that would have taken them years to achieve; 2. It stimulates new perspectives on research thanks to daily interaction and collective intelligence of the international and multidisciplinary cohort of fellows and to the individual mentoring; 3. It enriches the fellows’ professional networks with local and international contacts in academia and beyond to develop long-term collaborations; 4. It offers vast training opportunities that improve fellows' research and non-academic skills and level up their individual professional achievements and prospects.  FIAS will impact the career development of each fellow, consolidating its strong track record in terms of recruitments and promotions, publications, awards and grants, and extra-academic recognition.

Mots clés : excellence innovation incubation multidisciplinary mentoring

Participants :
- Réseau français des instituts d'études avancées (France) — Coordinator, beneficiary, Autres, subvention : 4042000.0 €
Projet PhD_at_Tec21 (Horizon Europe, appel à projets 2024)
Action : Cofund Doctoral programme
Statut du projet : SIGNED

The socio-economic challenges associated with the major industrial and environmental transitions of the 21th century require tackling engineering problems of increasing complexity. The PhD@Tec21 doctoral programme aims to train the next generation of experts in mechanical and process engineering. The trained fellows will become tomorrow’s leaders in strategic application areas such as environmental engineering, bio-engineering, sustainable energy, transportation, ecotech and cleantech, etc. The doctoral programme is supported by the LabEx Tec21, a well-established “Excellence Laboratory” in mechanical and process engineering at Univ. Grenoble Alpes (UGA). This will bring PhD@Tec21 unique advantages such as: (i) high-risk high-reward multidisciplinary scientific themes; (ii) cutting-edge research topics selected through an evaluation process by international experts; (iii) an extensive network of existing collaborators in both academia and industry, which will be exploited to offer secondment opportunities; (iv) highly qualified and experienced supervision teams; (v) access to state-of-the-art experimental and computing facilities. The training programme has been designed to equip the fellows with a comprehensive and balanced skillset. Mandatory secondments to international academic or industrial partners will provide further experience of the international and inter-sectoral dimensions. The acquisition of skills will be monitored through individualised Career Development Plans. Particular attention will be paid to recruitment and selection procedures carried out by external and independent experts, based on transparent criteria. Recruited fellows will be offered excellent working conditions, and will have the opportunity to pursue their project in one of the most beautiful university campuses in France.

Mots clés : mechanical engineering, process engineering, bioengineering, research challenges, multi faceted training, socio economic applications, international environment

Participants :
- Université Grenoble Alpes (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1663200.0 €
Projet GenoSpec (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

GenoSpec” aims at understanding the genomic processes underlying host adaptations of the ants-specific fungi from the species complex Ophiocordyceps unilateralis sensu lato by using a population genomics approach. This knowledge will contribute to the understanding of adaptive evolution, which is a major topic in evolutionary biology, and has potential applications in the development of fungal biological control agents against insect pests. Strains of O. unilateralis specific to three different ant species will be isolated from Thailand and their genomes will be sequenced, to identify the genomic changes involved in adaptation, e.g., the genes with signatures of positive selection or specific to particular hosts. Various sampling sites will allow inferences on the recent demographic history that could blur the footprint of positive selection. Dr. Noppol Kobmoo will bring his knowledge and skill on these particular fungi to enrich the expertise and the panel of biological models of the host institution (ESE laboratory, Université Paris-Sud, FRANCE) while gaining new expertise on population genetics at a genomic level. This project will start a fruitful collaboration between the host institution and BIOTEC (THAILAND) where the Fellow will return permanently after the project.


Participants :
- Université Paris-Saclay (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173076.0 €
Projet Genetic Vaccine (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Genome editing has enriched our understanding of mechanisms of the human pathology. Genome editing took a significant advance with the recent development of the CRISPR-Cas9 technology. CRISPR is an acronym for: Clustered Regularly Interspaced Short Palindromic Repeats and it is an adaptation of a prokaryotic functional system. It uses a single guide RNA to direct Cas9 activity to a specific part of the genome, therefore, this system can be used for gene editing and regulation. Cancer is a genetic disease where some DNA-damaged cells begin to divide without stopping and spread into surrounding tissues. Interestingly, in some tumors, there is a dependency of a single oncogenic activity (oncogene addiction). This phenomenon indicates that mutations in key oncogenes (driver mutation) are able to drive carcinogenesis and maintain the tumor phenotype. Suggestively, if we can prevent or disrupt these mutations, we can difficult carcinogenesis or damage an established tumoral phenotype. In this proposal, we seek out for using Crispr-Cas9 technology to target driver mutations and evaluate its therapeutic and preventive value. To develop a proof of concept, we will focus on lung cancer driven by KRAS mutations. The generating of a transgenic mouse expressing Crispr-Cas9 designed to target the mutation Kras C12C will allow us to test the potential cancer-resistant phenotype and raise the concept of Genetic Vaccines.

Mots clés : cancer, lung adenocarcinoma, crispr cas9, mutation, oncogene

Participants :
- University of Granada (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160932.48 €
Projet FETA (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Geochemical and geophysical observations indicate that much of Earth’s mass was accreted during large impacts between planetary embryos already differentiated into a metallic core and a silicate mantle. These collisions played a crucial role in setting the stage for Earth evolution, including the initiation of plate tectonics, the generation of Earth’s magnetic field, and the development of life. Each impact delivered prodigious amounts of energy, melting the projectile and the protoplanet's mantle, and creating an environment where the metallic liquid core of the projectile was released within a molten silicate magma ocean. The fate of the projectile’s core following impact affected the efficiency of chemical equilibration between metal and silicates, and therefore the geochemistry of Earth’s deep interior. Recent studies have provided clues on the physical processes involved, however, major questions remain. For instance, does the projectile’s core remain coherent or does it fragment into drops during the impact ? This project includes the first analog fluid mechanics experiments on large impacts that formed the Earth, and combines them with numerical simulations and theory. Complementary to simulations, experiments can produce turbulence, as expected during Earth accretion. Regime diagrams and scaling laws on turbulent mixing obtained from these experiments and simulations will provide key constraints to interpret geochemical observations in terms of accretion time scales and processes. Bridging gaps between fluid mechanics, geodynamics, impact cratering and geochemistry, this project is expected to bring fundamental progress in our understanding of the origin of the Earth, planets, and exoplanets. The researcher’s expertise in Earth accretion and in lab experiments, acquired in the USA, will be reinvested in Europe through this project. Because the work is in fluid mechanics, the host organisation is the ideal place for this project.

Mots clés : fluid dynamics of earth s interior, earth accretion, magma ocean, core, mantle differentiation, turbulent mixing, two phase flow, liquid impacts, analog experiments, regime diagrams, scaling laws

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet SPINCAT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Given the rapid development of information-based society, it becomes more important and urgent to find efficient means to store and process huge amount of information. While the traditional transistor technology is becoming a bottleneck, spintronics and quantum information science stand out as two promising candidates to innovate our current computing and storage concepts. The combination of these two fields can allow us to take advantages of both fields to build solid-state platforms for studying quantum phenomena and performing multi-functional quantum information tasks. However, their interaction was limited because of the different properties of classical magnetization in spintronics and quantum qubit in the quantum information. The situation is changing with the progress of magnonic spintronics, which manipulates the collective magnetic excitation so-called magnons, and fits neatly with continuous variable quantum information. In the SPINCAT project, I will provide a route to bridge the two fields by examining the generation and manipulation of the magnonic Schrödinger cat state in the continuous variable quantum information science. In particular, I will (i) generate and manipulate of magnonic cat state in magnetic ordered systems driven by parametric pumping, (ii) ascertain its robustness under the influence of magnon-photon and magnon-magnon scattering, (iii) detect this nonclassical state by coupling it to the cavity photons, and (iv) identify its applications in quantum computing and quantum teleportation. The SPINCAT is an original, novel and highly interdisciplinary project covering spintronics, quantum optics and quantum information. The successful implementation of this project will significantly broaden the horizon of each subfield, and fertilize the on-going topics in magnonic spintronics in particular. Further, the training and skills acquired in this project would increase my competence in academics and boost myself to become a mature researcher.

Mots clés : magnons, schr dinger cat

Participants :
- Utrecht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187572.48 €
Projet CareInTrials (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Given the tragic legacy of unscrupulous research conducted on human subjects during the 20th century, ethics debates and regulations have taken a precautionary approach that gives pivotal attention to individual autonomy and protection of vulnerable subjects. While this approach has led to a much-needed increase of awareness about the importance of respecting human dignity and human rights in biomedical research and clinical trials, it risks causing two unintended consequences: 1) it might overshadow positive understandings of clinical trials; 2) it might limit participation of adolescents and young adults. CareInTrials therefore takes a bottom-up approach to research ethics and focuses on the experiences and narratives of youth participating in clinical trials. It is an empirical philosophy study. On the one hand, it conducts ethnographic observations and interviews with participants, their parents/legal representatives and researchers in a leading European Clinical Trials Unit. On the other hand, it does a philosophical analysis, which focuses on lived embodied experiences and the situated existential dimension of youth. For scientific rigor, a secondment in a Research Unit dedicated to philosophy and history of science is part of the action. This research ultimately aims to provide new insights and recommendations for more nuanced and tailored regulations on clinical trials, which acknowledge both youth’s demand for autonomy and their condition of vulnerability. Given the intersectoral and international cooperation involved, this action represents a unique opportunity for the researcher to gain experience and visibility to be spent in future academic and health-related employments, while contributing to societal strive for youth’s inclusion and empowerment.

Mots clés : international regulations, research ethics, clinical trials, patient reported experience

Participants :
- Hospital Universitario La Paz (Espagne) — Coordinator, beneficiary, Autres, subvention : 160932.48 €