Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SCIBOS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

This research project will study the career prospects (geographical and institutional mobility, communication networks, length of tenures) of state functionaries in Byzantium between the 7th and the 9th c., and their social and cultural identity through their self-representation, their professional choices, piety, and ethnic origin. Next to the admittedly limited narrative and archival sources, this project will rely as its main source on Byzantine lead seals, a source material that only few scholars in the field of Byzantine Studies have the ability to analyse. One of the primary objectives of the project is to move beyond traditional approaches in the study of Byzantine lead seals. This will be accomplished, first, by demonstrating the potential of this material for the study of a past medieval society and particularly for the fields of social and cultural history. Second, by the introduction of tools from the Digital Humanities, such as SigiDoc that has been developed through another past MCSA project by a scholar of my host institution. There will be a thorough research for relevant material which will be recorded in a standard database that will serve as basis for the further process of the material in order to answer our research questions and to complete all the products of the project. The main products of this study will consist of: 1) an online database on the career of officials; 2) an article on the career and communication networks of officials; 3) online publication of a corpus of unpublished lead seals; 4) a list of decorative and iconographic motifs on lead seals; 5) a monograph with the final overall research results. Several targeted training and research activities (the application of digital tools in Byzantine sigillography, research in Bulgarian archaeological archives, seminars, and courses) have been already planned, aiming at the successful completion of the project and the enhancement of the prospects of my future career.

Mots clés : byzantine studies, sigillography, social identity, cultural identity, digital humanities

Participants :
- Sorbonne Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
- Académie d'athènes (Grèce) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Académie bulgare des sciences (Bulgarie) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet M4IEMA (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Islands are hotspots of biocultural diversity. The SIDS Lighthouses Initiative provides a global framework for energy transition on islands and the Smart Islands Initiative was developed by the European Union to encourage innovative island solutions that support sustainable economic growth. This challenge has been underlined in various IPCC and UN reports because island economies are vulnerable to global climate changes. The research project is highly relevant and actual. Worldwide, more than 700 million people live on islands which are frequently considered ideal environments for the transition to 100% renewable energy systems. Furthermore, island economies need to be energy resilient for instance, to invest in energy diversity, infrastructure, research and development, and governance. A foresight methodological framework development to integrate the political, economic, socio, technical, environmental, cultural and managerial systems (PESTECM) is a critical phase to go beyond island energy metabolism and foster the development of synergetic resilience. This project aims to create a methodology for island’s synergetic resilience assessment considering the synergies and trade-offs between different energy resource-use patterns and sectoral development paths. In addition, this project will implement the novel validated and developed methods in previous research projects by the research team, and evaluate the potential dynamizer role of hydrogen in island developing countries from PESTECM approach and its fostering impact. Last but not least, it will be constructing synergetic resilience scenarios for future development paths for Cuba, as a study case, in the interlinked PESTECM approach for the multisectoral planning to achieve sustainable island metabolism.

Mots clés : sustainability assessment methodology foresight studies renewable energy sources island s energy metabolism

Participants :
- Université de Turku (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 242116.8 €
Projet GROW (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Across Europe, 11 million university students (80%) combine their studies with paid employment. A highly relevant question, therefore, is how students’ lives are affected by student employment in the long run. Yet, existing segmented research has failed to provide a comprehensive approach to assess the implications of student employment for students later in life: It has remained unclear who gains and risks when working while studying, and under which conditions. GROW will break with these previous conventional approaches by taking on a holistic approach which will jointly analyse the positive and negative effects of student employment for educational and labour market outcomes. GROW will bridge segmented theoretical views from psychology, sociology, and labour economics by implementing a life course approach, creating a more comprehensive, nuanced, and interdisciplinary understanding about the implications of student employment for students’ lives. To do so, it uses multichannel sequence analysis, and mixture hidden Markov modelling to jointly analyse educational and labour market trajectories based on high-quality longitudinal data from four carefully selected European countries belonging to three different welfare states: Liberal (UK), Conservative (the Netherlands, Germany), and Social Democrat (Finland). It emphasises gender and social origin differences in patterns and implications of student employment, as well as differences across students’ fields of study, and national contexts. The project includes an ambitious dissemination and communication plan targeting academic scholars, policy makers, managers of European Higher Education, and Higher Education Students. As such, the GROW project aims at strengthening the Social Dimension of the European Higher Education Area and contributes to the UN Sustainable Development Goals 4 (quality education) and 10 (reduce inequality).

Mots clés : student employment, higher education, working while studying, social inequality, life course, sequence analysis

Participants :
- Université de Turku (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet FRICTIONS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

FRICTIONS investigates the substantial gap between European policy commitments for a climate-neutral economy, and the reality on the ground for small initiatives across Europe, who are making transformative endeavours for climate action in their own communities, but face regulatory systems that do not fit the visionary work they do. FRICTIONS engages with this impasse at a practical level, through the day-to-day practice of administration as a place where new, innovative procedures, relations and ways of thinking about regulation can be imagined and forged. The research approach departs from notions of progress and modernity that characterise much of transition discourse, to concentrate instead on systems change at the micro-level of habit, everyday process and experience – with particular focus on procedural spaces and relationships where things often feel stuck. Drawing on my research practice as an artist-activist working across art, business and social fields, the research objectives are to 1) unearth, illuminate and negotiate the kinds of regulatory frictions that small, sustainably-minded organisations regularly encounter and the innovative actions they are already making; 2) design creative experiments in administrative practice for how such organisations can prefiguratively navigate complex regulatory systems across different EU jurisdictions; and 3) establish new channels, procedures and vocabulary to promote innovative administrative practice as a transformative means to strengthen and sustain culture-led innovation for the EU's critical ecological transition. To achieve these objectives, FRICTIONS will engage methods from participatory action research and tactical art, working collaboratively with 3 exemplary small-scale cultural initiatives (NL/SI/HR), and establish a new research centre, the Institute for Experiments with Business (IBEX), as a platform to continue this work beyond FRICTIONS.

Mots clés : artistic research, socio cultural aspects of ecological transition, critical management studies, feminist economic geography, diy culture, organising for sustainability

Participants :
- Brave new alps (Italie) — Coordinator, beneficiary, Autres, subvention : 156778.56 €
- The institute for technology in the public interest (Belgique) — Partner, associated partner, Autres, subvention : 0.0 €
- Community economies institute limited (Australie) — Partner, associated partner, Autres, subvention : 0.0 €
Projet CatHyMiNi (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The transport industry is going through a revolutionary moment in its quest to reduce its carbon footprint, with biofuels being one of the viable options. High productivity, lipid content and its ability to capture CO2 make microalgae a competitive biomass. New technologies such as hydrothermal liquefaction (HTL) has recently attracted the attention in research as it avoids the energy-costly drying step and produces bio-oil at mild temperatures. Nonetheless, conventional HTL process suffers from bio-crudes high nitrogen content, mainly caused by protein content. Furthermore, the biocrude’s high oxygen content reduces its calorific value making biocrude unattractive in addition to its high NOx emissions during combustion. Since nitrogen and oxygen in biocrude respond differently to processing temperature, an approach that would favor simultaneous reduction of both would be revolutionary.  The nitrogen removal before the main HTL process could be the solution. In this perspective, the combination of microwave pretreatment and HTL process can be promising. However, this non-selective method may compromise bio-oil yield. In MicroWCatHydroN, we investigate nitrogen-selective catalysts to specifically target nitrogen compounds and maintain the trade-off between desired bio-oil yield and properties. The catalytic activity of nickel can promote hydroisomerization and deoxygenation reactions, thereby improving bio-oil’s cold flow properties and heating value. Overall, this green chemistry-compatible route is economically and technically feasible.  Industrial scale-up of algae conversion requires a complete characterization of its complex degradation mechanisms and phenomena occurring during the process in order to understand how nitrogen compounds are formed and consumed. In this sense, MicroWCatHydroN aims to develop a new chemical kinetic model for ParaChlorella kessleri liquefaction. In conclusion, research is expected to increase the production of high-quality bio-oil.

Mots clés : hydrothermal liquefaction, microwave, kinetic modelling, denitrification, saf, microalgae

Participants :
- Institut Mines-Télécom (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet PhotoCyX (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cyanobacteria, the green microbial factories, are able to produce important biochemicals such as biofuel and bioplastics that offer a timely solution to many of the environmental challenges of our time, such as pollution and fuel security. The stability of the process and production yield, however, are dependent on the optimum synthesis of the enzymes involved in their metabolic processes. The goal of this research is to create a cyanobacterial expression tool that responds to red light based on a phytochrome photoreceptor. This tool will enable precise and highly tunable control of cyanobacterial gene expression with two wavelengths of red light. While the study is expected to show the potential of photoswitches for controlling biological processes, it will likely disclose distinct obstacles in the search for an ideal cyanobacterial expression system. The project will start with the construction of expression plasmids and their application to the cyanobacterium Synechocystis sp. PCC 6803. The light responses of the resulting expression strains will then be tested by illumination experiments, where the increased expression of the reporter (green fluorescent protein) will be detected with fluorescence spectroscopy. The proposed 24-month project will take place at the University of Jyvaskyla (Finland) under the supervision of Dr. Heikki Takala. The project also includes a two-month secondment training session at the laboratory of Prof. Andreas Möglich at the University of Bayreuth (Germany). This project is designed to combine the skills of the researcher in cyanobacterial studies and the expertise of the supervisor in phytochrome biology. Overall, the planned activity is methodically structured to nurture new abilities while addressing knowledge gaps. The project will provide the applicant with academic excellence, leading to higher prospects for a tenured academic position in Europe.

Mots clés : photoreceptor, cyanobacteria, phytochrome, gene expression

Participants :
- Université de Bayreuth (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Jyväskylä (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
Projet CRISPRGels (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Cystic fibrosis (CF) is the most common genetic lung disease (monogenic autosomal recessive disorder) worldwide and currently there is no cure. The emergence of powerful gene editing tools like CRISPR-Cas (“clustered regularly interspaced short palindromic repeats/associated protein 9”), now provides the opportunity to correct the disease-causing mutations which can potentially cure CF. The present research project proposes the development of core-multishell nanogels (NGs) yielding efficient transmucosal delivery of CRISPR-based gene editing tools which can address the challenges for treatment of CF at European level. This project brings together a talented, highly motivated and young Researcher (Dr. Krishan Kumar) with background in polymer chemistry (phase transition temperatures, understanding structure of colloids, bio-macromolecular interactions) and protein science (structural stability, immobilization, enzymatic activity); and an innovative institute POLYMAT in developing biomedical solutions for treating CF diseases based on nanogels mediated controlled release of CRISPR/Cas9 complex. CRISPRGels will focus on advancing the young researcher’s career through development and manufacture stages of non-viral gene delivery systems facilitating the curative gene editing approaches for treatment of CF patients. The host supervisor Prof. Marcelo Calderón is globally recognized researcher working in area of transmucosal delivery using nanogels (NGs). The behavior and interactions of the NGs will be systematically investigated in CF patient-derived sputum and CF bronchial epithelial models. Most efficient NGs will be validated on pre-industrial scale. Multidisciplinary expertise required for CRISPRGels will be complemented by highly experienced research teams Responsive Polymer Therapeutics Group (RPTG), Translational Organ Models Group (TOMG) and i+Med company.

Mots clés : nanogels crispr cas9 non viral gene delivery cystic fibrosis gene therapy

Participants :
- Hôpital universitaire de la Charité de Berlin (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université du Pays basque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206641.2 €
- I+med s coop (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Basque center for macromolecular design and engineering polymat fundazioa (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet SiNanoCrop (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The impact of plant pests on global crop yields is a significant concern, leading to an annual decrease of more than 30% in crop production. The whitefly alone incurs losses exceeding $300 million each year, primarily due to its role in transmitting harmful plant viruses like the Tomato Yellow Leaf Curl virus (TYLCV), which poses a substantial threat to tomato crops worldwide. The use of conventional pesticides raises environmental alarms, negatively affects beneficial insects, and contributes to pest resistance. Initiatives like the European Green Deal aim to promote sustainable agriculture by reducing chemical pesticide usage by 50% by 2030. Spray-induced genetic silencing (SIGS), harnessing the RNA interference (RNAi) mechanism, has emerged as a promising alternative to conventional pesticides. This non-GMO approach offers a sustainable and pathogen-specific protection method by silencing key genes in target pests through the foliar application of dsRNA molecules. However, certain challenges remain unresolved, including the cost-effective production of dsRNA, the ability to control multiple species simultaneously, and dsRNA stability and transport in crop environments. This project seeks to overcome these challenges by implementing innovative, safe, and cost-effective approaches. Firstly, we will synthesize dsRNA containing regions from both whitefly and TYLCV through microbial fermentation and apply a simple purification method to achieve high-efficiency hybrid dsRNA isolation. Secondly, we will design new biomass-based formulations using nanopolyplexes as carriers to efficiently protect and deliver the dsRNA. Thus, we will develop advanced biocontrol strategies for dual protection against both the insect vector and its host virus in tomato. Through the integration of polymer science, nanotechnology, and biotechnology approaches, our efforts aim to advance dsRNA-based biopesticide technology and facilitate its lab-to-field transition.

Mots clés : biopolyelectrolytes, polyamines, nanoformulations, dsrna, biocontrol, crop protection, tomato

Participants :
- Université du Pays basque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
- Conseil supérieur de la recherche scientifique (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Basque center for macromolecular design and engineering polymat fundazioa (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet NeuroEDIT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Age-related neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD), are a major public health problem since there is no effective treatment due to the poor understanding of the pathological processes involved in neuronal death. RNA editing, particularly A-to-I changes mediated by ADAR enzymes, stands as the most prevalent form of post-transcriptional RNA modification. Emerging evidence indicates that the efficiency and pattern of RNA editing in the brain are dynamically regulated during aging and can potentially lead to some neurodegenerative diseases. Despite recent advances in the topic, much remains unknown about how ADAR enzymes regulate RNA-editing and how A to I changes are involved in the onset and development of TDP43 proteinopathies such as ALS and FTD. In ALS, previous studies have described that nuclear clearance of TDP-43 leads to ADAR2 dysregulation and downstream changes in motor neuron RNA editome. However, these results are questioned in other studies using different approaches. Moreover, the function and regulation of RNA editing have not yet been studied in FTD. To address this critical knowledge gap, I will characterize ADAR expression and processing, their protein regulatory network and localization on brain tissue and iPSC-derived from FTD patients and controls. Then, I will describe the resultant RNA editome by applying direct long-read Oxford Nanopore and Illumina RNA-sequencing technologies, coupled with new cutting-edge bioinformatics pipelines. Finally, after identifying the disease-modifying A-to-I events of interest, I will employ antisense RNA strategies to manipulate specific RNA-editing patterns to investigate their function and therapeutic potential in FTD-TDP43. Overall, NeuroEDIT will generate fundamental knowledge to understand the role of RNA editing in neurodegeneration which may result in novel therapeutic targets based on RNA technology.

Mots clés : rna editing, rna processing, adar, long read sequencing, tdp43 proteinopathies, ftd, neurodegeneration

Participants :
- The University of Melbourne (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Biogipuzkoa Health Research Institute (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €