Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet PORASIS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Reconfigurable Intelligent Surface (RIS)-assisted integrated sensing and communication (ISAC) is emerging as a key technology for future wireless systems, particularly in monitoring and managing network-connected unmanned aerial vehicles (UAVs) with line-of-sight (LOS) links. ISAC transmitters can use echo signals to detect the angle of arrival of unauthorized UAVs and leverage channel information to enhance secrecy rates.  Motivated by these unique capabilities, we aim to optimize the performance of RIS-assisted secure ISAC systems. Our objectives are: 1) to develop a RIS-based collaborative sensing mechanism to mitigate asynchronous reception effects and improve sensing performance; 2) to design methods for unauthorized target detection and sensing and communication (SAC) channel parameter prediction based on perceived information; 3) to create algorithms for joint optimization of resource allocation, RIS phase shifts, artificial noise (AN), and UAV trajectories to maximize the secure transmission rate of ISAC systems.  Achieving these objectives will provide immense benefits to the wireless industry and sectors advancing 5G/6G technologies. The Fellow anticipates that the project outcomes will reduce network deployment costs for mobile network operators by 30%, while enabling high-quality mobile data services for citizens, boosting the digital economy, and creating new jobs.

Mots clés : integrated sensing and communication, reconfigurable intelligent surface, uav communication, secure transmission, collaborative sensing

Participants :
- Ranplan wireless network design ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Sheffield (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 345234.9 €
Projet MACROCODE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Macrophages are essential cells of the innate immune system, playing crucial roles in coordinating inflammatory responses and maintaining homeostasis. In cases of chronic inflammation, damaged tissues release abnormal signals that attract macrophages precursors to the local environment and drive macrophages toward a proinflammatory phenotype. This creates a feedback loop that sustains inflammation. The consequences to society are huge: chronic inflammatory diseases are among the leading causes of death and disability worldwide.  Recent single-cell multi-omics studies have identified dysregulated macrophages as central players in chronic inflammation, but the molecular mechanisms sustaining these responses remain poorly understood.  MACROCODE aims to unravel the molecular mechanisms governing the altered function of macrophages during chronic inflammation.  The specific aims of this project are:  1. Use CRISPR-Cas9 technology with single-cell read-outs to perturb genes in macrophages that show dysregulated expression between healthy and diseased states in chronic inflammatory conditions . Genes will be selected by creating an integrated single-cell transcriptomics atlas of macrophages in both health and disease. 2. Develop a computational framework using bioinformatics and AI tools to link these perturbed genes to transcriptomic programs, cellular functions and in vivo disease phenotypes.  3. Validate key genes by modulating their expression using dCas9-VPR or KRAB systems, and evaluate the effects on macrophage differentiation, identity and function.  Altogether, MACROCODE will decode the genetic regulation of macrophage dysfunction in chronic inflammation. This multidisciplinary project will equip me with advanced skills in genomics and bioinformatics, enhance my leadership and transferable skills, and prepare me for a future as an independent leader in the field of gene therapy for immune diseases.

Mots clés : macrophages perturbational screening single cell transcriptomics chronic inflammation

Participants :
- Wellcome Trust (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 260347.92 €
Projet EcoDiv (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Crop diversification offers substantial potential benefits for smallholder farmers in southern Africa. Positive interactions between diverse crops can lead to higher and more stable yields, more nutritious diets, better economic returns, and lower agrichemical use. However, choosing the right diversification option to realise these benefits is challenging. Interactions between crops can be negative as well as positive, and it is not yet well understood which features of different crop combinations and their environments determine their overall performance.  EcoDiv will address this knowledge gap by undertaking an ambitious analysis of large datasets from agricultural field experiments across Zimbabwe, Zambia and Malawi. Specifically, EcoDiv will 1) quantify the relationships between crop combination productivity and crop traits under different environmental conditions, 2) explore which characteristics of crop combinations are important to meet different socioeconomic needs, and 3) investigate whether the effects of crop combinations on microhabitat conditions explain their performance. This research will produce an ecological framework for crop diversification in southern Africa: an understanding of the key interactions between crop traits and environmental conditions that predict the performance of different crop combinations in different contexts.  To achieve EcoDiv’s objectives, Dr Chloe MacLaren (the research fellow) will work with interdisciplinary and international research teams at two host institutes, the Swedish University of Agricultural Sciences (SLU) and the International Maize and Wheat Improvement Centre (CIMMYT). EcoDiv will advance Dr MacLaren’s career by developing the knowledge, skills, and networks needed to achieve leading research positions in ecology for agricultural development. Both hosts will benefit from transfer-of-knowledge in new statistical methods, and from strengthened collaboration around shared research goals in sub-Saharan Africa.

Mots clés : crop diversity, sustainable intensification

Participants :
- Université suédoise des sciences agricoles (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 277291.2 €
- Centro Internacional de Mejoramiento de Maíz Y Trigo (Mexique) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet SLIDE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The protection of cultural heritage buildings (CHB) against slow-moving landslides has become increasingly urgent due to climate change exacerbating these threats. Among CHB, historic masonry churches (HMC) warrant special attention due to their global spread, high risk exposure, and high vulnerability to slow-moving landslides. SLIDE addresses this challenge by using an interdisciplinary approach that combines remote sensing, structural and numerical analysis, and soil-structure interaction modeling. For the first time, the project will thoroughly characterize and model the action of slow-moving landslides on HMC using remote sensing techniques. It will also enhance understanding of the structural response of HMC to slow-moving landslides and develop tools for damage prediction at a territorial scale. Implemented at TU Delft under the supervision of Prof. Giorgia Giardina and benefiting from a secondment at UNIGE under the co-supervision of Prof. Chiara Calderini, SLIDE is designed to support Dr Ferrero in achieving her career objectives. The project will enable her to acquire new scientific and transferable skills. Additionally, it will strengthen her international network and enhance her ability to secure research funding, aiding her development towards an independent research position. In the long term, SLIDE aims to: (i) generate new insights into the structural response of CHB to slow-moving landslides, (ii) enhance policymaking and enable timely damage prediction and interventions, (iii) promote the design of new strengthening measures to reduce the vulnerability of CHB, and (iv) raise public awareness about the importance of CHB protection. Through these efforts, SLIDE will mitigate damage from slow-moving landslides to CHB, contributing to the preservation of cultural heritage. In doing so, the project will also support the UN Sustainable Development Goal 11 and the European Union’s commitment to safeguarding heritage buildings.

Mots clés : cultural heritage buildings historic masonry structures heritage protection remote sensing landslide risk climate change vulnerability and damage assessment

Participants :
- Université de technologie de Delft (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 217076.16 €
- Université de Gênes (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet BIAST (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Bullying is a pervasive social issue that severely impacts mental health, as underscored by the European Commission's comprehensive approach to mental health in 2023. Despite ongoing prevention efforts, bullying remains widespread in Europe and globally. As bullying is a social phenomenon, the role of bystanders is crucial for intervention and prevention. However, only about 17-19% of bystanders choose to intervene, and understanding the reasons behind this remains a key challenge. One significant research gap is the reliance on self-report measures, which capture conscious thoughts and reasoning but miss unconscious processes shaping bystander behavior. In this context, studying visual attention offers critical insights into how individuals understand social dynamics and react during bullying incidents. However, few studies in the bullying field have analyzed visual attention, relying on simplified stimuli such as vignettes or 2D videos and none have deeply examined bystanders' behavior. Therefore, the overarching aim is to identify recurring attention patterns associated with different intervention behaviors. The project has two key objectives: 1) to develop and validate VR scenarios that simulate realistic bullying environments, integrated with eye-tracking to study attentional patterns; 2) to investigate how bystanders’ visual attention correlates with their intervention choices while considering the moderating effects of personal variables such as empathy and moral disengagement. BIAST will be supported through a secondment at the University of Bologna. This interdisciplinary project will contribute new theoretical insights into bystanders’ bullying intervention, advance research in visual attention, and inform future anti-bullying programs. Additionally, the Marie Curie fellowship will allow me to gain interdisciplinary expertise, build international collaborations, and strengthen my leadership skills in bullying research.

Mots clés : bullying eye tracking visual attention virtual reality

Participants :
- Université de Stavanger (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 251578.56 €
- Université de Bologne (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet NETNOVO (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Climate change is altering species distributions across the globe. Because in mutualistic interactions, as the ones between plants and seed dispersing animals, species rely on each other to persist, climate-driven species shifts have been shown to reduce areas of cooccurrence between mutualistic partners, breaking interactions, reducing ecosystem service provision, and causing co-extinction cascades. But so far, we have overlooked the ecological communities that species may face in their new distributions, and the novel ecological networks these communities may form. For instance, seed-dispersal interactions are mediated by species traits, such as the gape width of animals and seed sizes of plants, so that the climate-driven rearrangement of species traits may present new interaction partners, offering novel interaction opportunities through interaction rewiring, ultimately resulting in novel seed-dispersal networks. The aim of NETNOVO is to build and assess the structure, resilience and functioning of novel seed-dispersal networks under climate change. I will combine species trait data with climate, species distribution, and network assembly models to: O1) map the global loss and potential gain of seed-dispersal interactions under climate change, O2) predict the resulting novel seed-dispersal networks, and estimate their structure, and resilience, and O3) assess the seed-dispersal service that novel networks may provide. NETNOVO will not solely focus on interaction loss; instead, NETNOVO aims to shed light on the formation of novel ecosystems, an urgent enterprise which is beyond the state-of-the-art. Whilst increasing my international mobility and career development, expected NETNOVO results include three scientific publications, outreach activities to promote societal awareness on the effects of climate change on mutualistic interactions, and meetings with conservation agencies to discuss strategies to restore interactions.

Mots clés : novel ecosystems, seed dispersal, species distributions, climate change

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 247553.28 €
Projet SAIL-GSC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

Services trade has become an increasingly vital component of global supply chains, driven by advancements in information and communication technology (ICT). The ongoing technological revolution, particularly the rise of artificial intelligence (AI), holds the potential to further transform services trade. However, largely due to a lack of detailed data, significant gaps remain in our understanding of how services trade interacts with other forms of globalization, such as goods trade, and how it impacts firms and workers. This project, SAIL-GSC: Services, Artificial Intelligence, and Labor Markets: Navigating Firms and Workers through modern Global Supply Chains, aims to address these gaps through rigorous empirical analysis. The research is structured around three core objectives. First, it will integrate services trade into a broader analysis of firms’ international activities, including goods trade and foreign direct investment (FDI), to provide new insights into their interrelationships. Second, it will evaluate the causal impact of offshoring—both goods and services—on labour market outcomes such as wages, job stability, and income inequality, with a focus on the differential effects across various worker types and occupations. Third, it will investigate how technological advancements, particularly AI, influence firms’ decisions to engage in services trade and the subsequent consequences for workers. By leveraging newly available firm level data on services trade from Denmark, which can be linked to other micro level information on goods trade, foreign affiliates, and employer-employee relationships, the project aims at improving our understanding of the role of services trade in global supply chains. The findings of the project are expected to be relevant not only to academic research but also to policymakers, business leaders, and the general public as they navigate the challenges and opportunities presented by globalization and technological change.

Mots clés : services trade, global supply chains, firms, offshoring, labor market, technological progress, artificial intelligence, globalization

Participants :
- Université d'Aarhus (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 263393.28 €
Projet HiDDyn-AF (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Atrial fibrillation (AF) is characterized by disorganized atrial electrical activation leading to a rapid and irregular heart rate. Incidence rates are rising to epidemic levels with aging populations. AF disrupts left atrium (LA) fluid dynamics, increasing the risk of stroke and catheter ablation seeks to restore sinus rhythm. We aim to develop of personalised risk stratification in AF patients, begin to optimise ablation treatment and generate novel findings about the pathophysiology of AF. High-resolution Decryption of Left Atrial Haemodynamics in AF (HiDDyn-AF) adopts a cross-disciplinary approach to combine computational fluid dynamics (CFD), 4D flow MRI, late-gadolinium enhancement MRI and computed tomography to create a novel model of LA flow. This model will be applied to investigate AF patients pre- and post-ablation. Furthermore, LA flow will be compared with myocardial fibrosis and strain. Previously, LA flow has been modelled in small groups with idealised or patient-specific geometries. Some applied wall motion however none have been validated with 4D flow MRI as planned in HIDDyn-AF. The project will further extend the state-of-the-art by analysing many more cases than previous studies (N=50), to produce impactful results. The research questions are built on the complimentary experience of the host team, clinical collaborators, secondment team and the applicant. Accordingly, the objectives are to: develop a novel, high-resolution, validated model of LA flow (O1), define LA haemodynamics (vortices, WSS and turbulence) for AF (O2) and determine: the haemodynamic impact of ablation (O3), if haemodynamics predict recurrence of AF (<1 yr) (O4), if a relationship exists between LA myocardial fibrosis (O5), myocardial strain (O6) and haemodynamics. HiDDyn-AF consists of 6 work packages: project management, knowledge transfer & training, model development study, large cohort study of pre- & post-ablation patients, analysis & synthesis and dissemination.

Mots clés : atrial fibrillation, computational fluid dynamics, 4d flow mri, late gadolinium enhancement

Participants :
- Sorbonne Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 210962.88 €
- Université de Bologne (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Poly2Adapt (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Understanding if and how species are able to rapidly adapt to climate change is a major and challenging problem of modern biology. Can evolution operate quickly enough? Theory suggests that the genetic basis of most phenotypic traits is polygenic, and evolution can be rapid if it harnesses this reservoir of standing variation spread across the genome - ‘Poly2Adapt’. Recent theoretical advances suggest that the signature of real-time polygenic selection can be identified using time-series genomic data. Moreover, a recent paradigm-shift, framed in the ‘omnigenic model’ suggests that all genes which are broadly expressed, or in general all genomic regions broadly available in euchromatin, contribute to the heritability of complex traits. How can we use these theoretical advances in concert? Benefiting from a unique genomic time-series dataset comprising 1,000 samples from 2000 to 2021, the aim of Poly2Adapt is to quantify the polygenic variation relevant to real-time adaptation to climate change in the King penguin, a keystone species occupying one of the most climate change-impacted ecosystems. Coupling genomic time-series analysis with gene expression and chromatin accessibility data, I will rigorously test the theories of the polygenic (O1) and omnigenic (O2) models, using this information to develop metrics of adaptation potential (O3) for the conservation of other at-risk species. This will be the first study to detect the footprints of real-time adaptation proposed by the polygenic and omnigenic models in a wild species. The objectives are directly relevant to the priorities of Horizon Europe, ‘to tackle climate change’, in particular Mission 1: Adaptation to Climate Change. I will harness interdisciplinary expertise from the host, secondment and collaborators to deepen my skills in evolutionary theory, bioinformatics, and population and conservation genetics. Together, we are well-positioned to employ powerful new approaches to pursue this timely research.

Mots clés : climate change, evolutionary genomics, polygenic selection, population genomics

Participants :
- Université de Ferrare (Italie) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Université polytechnique des Marches (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet CLUS_COOP_CAT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

This proposal uses synthetic chemistry to develop a novel family of sustainable catalysts based on inexpensive and abundant elements. Up to 90% of chemical products manufactured require the use of catalysts, making catalysts crucial to how all modern commodities are made, from pharmaceuticals and pesticides to electronics and plastics. Catalysts often rely on the reactivity of expensive and rapidly depleting metals, such as Rh, Ir, and Pt. First-row transition metals (e.g., Fe, Ni) and main group elements (e.g., B, Al) are sustainable alternatives with costs up to 10 000 times cheaper. Individually, they are not competitive, but these elements can cooperate to create systems that are greater than the sum of their parts. We will build cooperative catalysts with these elements anchored on dynamic clusters, a fresh approach that will overcome barriers in the field. Three objectives will be met: -Synthesize a new family of cooperative catalysts with main group and 3d metal moieties anchored onto dynamic cluster platforms. -Catalyze two high-value synthetic transformations: olefin functionalization and CO utilization. - Understand the mechanism of catalytic transformations and cluster dynamics.  This cohesive and innovative project provides synthetic science with novel tools to make everyday molecules, and feeds into the European Commissions’ priority area ‘A European Green Deal’.  Dr Wenger has an outstanding track-record for his early career stage and a rapidly growing international reputation. He has demonstrated the necessary skills to deliver this project in a timely manner, and with the support of a MSCA fellowship, he will gain additional valuable skills in catalytic and kinetic science, spectroscopy, and computational chemistry, while building robust long-term collaborations across Europe. This fellowship will be a launchpad in Dr Wenger’s academic and personal development, and be instrumental in allowing him to establish his own independent research career.

Mots clés : main group chemistry, zintl chemistry

Participants :
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €