Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet QCDchallenge (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : TERMINATED

In the next decade, the experiments at CERN's Large Hadron Collider (LHC) will provide us with measurements of astounding precision, by shrinking experimental uncertainties to the level of 1%. These will be crucial to probe the fundamental laws of Nature at high energies. Indeed, small deviations between measurements and predictions of the Standard Model would signal the presence of new physics. To exploit the potential of the LHC, it is imperative that theoretical predictions will match 1% accuracy. In this context, Quantum Chromodynamics (QCD) poses one of the major challanges. Due to the relatively large QCD coupling constant, perturbation theory must be pushed to the frontier of third-order corrections, or Next-to-Next-to-Next-to Leading Order (N3LO). In addition, due to the multi-scale nature of QCD processes, perturbative corrections are enhanced by large logarithms of the scale ratios, which require to resum the perturbative series. This project will provide new methodologies for QCD calculations at high precision and state-of-the-art results for two complementary classes of enhanced contributions. One are the collinear logarithms, which govern the scale dependence of the parton distribution functions (PDFs). Building upon a breakthrough discovery that I achieved in multiloop renormalisation, I will compute the N3LO evolution of the PDFs, which addresses one of the largest sources of theoretical uncertainties at the LHC and enables QCD phenomenology to reach 1% accuracy. Another class of enhancements, known as high-energy logarithms, arises when the centre-of-mass energy of the collision is much larger than the momentum transfer scale. I will tackle the factorisation of the Next-to-Next-to-Leading Logarithms (NNLLs) in multi-leg amplitudes, building on recent progress in the calculation of multi-leg amplitudes and on a new approach that I developed to disentangle the building blocks of high-energy factorisation.

Mots clés : quantum chromodynamics, precision calculations, scattering amplitudes, splitting functions

Participants :
- Université de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 320924.16 €
Projet UrbanPACE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Human-driven environmental change is affecting wildlife globally, with climate change and urbanisation having major impacts. For instance, warmer spring temperatures and urbanisation have been shown to independently advance the timing of recurring events in wild populations like leafing in trees, hatching in caterpillars, and egg laying in birds. Getting the timing right is critical for predator species like tits that rely on feeding prey resources like caterpillars to their chicks each spring. Tits can adjust the timing of their egg laying to match the hatching of their prey by responding to environmental cues like spring temperatures. In urban environments these cues may be highly modified and less reliable, which could negatively affect urban wildlife populations like tits if they can not track the timing of their prey. The UrbanPACE (Urban Phenology and Anthropogenic Climate Effects) research program will aim to establish whether urban tit populations across Europe adjust their egg laying to spring temperatures in the same way as nonurban populations, and evaluate the ability of urban populations to keep pace with climate change and further advances in spring timing. UrbanPACE will then determine whether spring timings are in sync between species in urban food webs. Using citizen science initiatives across the UK, I will explore whether climate change can increase mismatches between urban species by disrupting the timing of key events like leafing in trees and egg laying in tits. My results will provide new insights on how multiple processes of anthropogenic change interact to affect wildlife and evaluate whether urban populations are more vulnerable to a warming climate.

Mots clés : urbanisation, urban evolutionary ecology, climate change, climate warming, phenology, lay date

Participants :
- Université d'Édimbourg (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet EEBio (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Extremophiles are extraordinary microbes that thrive in some of the harshest conditions on Earth – they can be found in the Yellowstone hot springs, at the deepest points in our oceans, underneath the ice caps in Antarctica and even in normal soil in our cities. These remarkable creatures have unique physiological features that allow them to survive and function where most other life forms cannot. My research aims to uncover these special adaptations and utilise them to develop new healthcare technologies. Traditional biological systems (involving normal cells) struggle to operate in harsh environments which include remote areas of our planet, least developed/developing countries and outer space. For example, medicines degrade faster in the high-radiation and low-gravity conditions of space. So, if they can be made by the extremophiles that can survive the harsh conditions in space, we can take extremophiles instead! However, programming extremophiles to make medicines or food can be challenging - I want to overcome some of these through this fellowship. I plan on studying these organisms in detail to understand their unique survival mechanisms. Then, I will choose combinations to focus on, and genetically modify the extremophiles for specific applications (e.g. therapeutic or sensing). Lastly, I will design this technology such that it can be used easily by everyone – particularly those without a science/research background. I have expertise in developing similar technologies from my PhD in Astropharmacy (University of Nottingham) and more recently through my postdoctoral work (Imperial College London). During my PhD, I developed and tested new technologies, including an experiment that will be sent to space next year. Skills from both these experiences will be crucial in achieving this project's multidisciplinary goals and unlocking new possibilities for healthcare in extreme environments and equitable healthcare for those in low resource environments.

Mots clés : extremophiles, cell free synthetic biology, biomanufacturing

Participants :
- Université nationale de Singapour (Singapour) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Édimbourg (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 361338.6 €
Projet EuLeSov (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Scholars have long mainly associated the concept of populism – and its corollaries, such as sovereignty – with radical right political parties. However, in Europe, since the 2010s, the rise and electoral breakthroughs of the radical left have been based on populist elements, i.e. on rhetoric (1) opposing the people to the elite, and (2) demanding a radicalisation of democracy through the concept of popular sovereignty. Most scholars retain a minimal definition of populism based on three elements (people- centrism, anti-elitism, popular sovereignty) and therefore consider national sovereignty as a corollary of left-wing populist discourses. On the contrary, EuLeSov will consider national sovereignty as a constitutive element of (partisan) left-wing populism. The project focuses on internal party dynamics (membership and leadership) and aims to examine why and how the people the people-centrism and anti-elitism of European left-wing populist parties is built on the concept of popular sovereignty (plebs-people) but also on that of national sovereignty (nation-people). The project applies a mixed-methods research design to the comparative study of four political organizations (La France insoumise [Unbowed France, LFI], Parti du travail de Belgique [Workers’ Party of Belgium, PTB], Podemos [We Can] and Sinn Féin [Ourselves]) in four countries (France, Belgium, Spain and Northern Ireland). This empirical approach will provide a better understanding of the mutations that the radical left party family has known since the collapse of the Soviet Union. Examining the articulation between left-wing populism and national sovereignty is today crucial as some of these parties have succeeded in taking power and others are at the verge of power. Understanding their relationship to national sovereignty contributes to the understanding of the major political changes that Western Europe has experienced since the Great Recession.

Mots clés : left wing populism sovereignty mixed methods comparative politics radical left political parties national popular nationalism

Participants :
- Université d'Édimbourg (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet CRYOCHICK (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Poultry products are the most consumed source of animal protein globally. To enable current and future poultry genetic improvement towards climate adaptation and sustainable farming practices to meet future nutritional demands, it is essential to maintain and make available the existing genetic diversity within and between the breeds. Gene banks can assist in conserving genetic diversity and reintroduction and implementation of important traits or genetic variants into poultry lines. The main goal of CRYOCHICK is to develop effective cryopreservation methods for ex-situ conservation of male and female chicken germplasm. Existing strategies and methods for gene banking of chicken reproductive material are not adequate for several reasons such as poor fertility rate of cryopreserved semen, the contraceptive effect in hen of glycerol (the most effective sperm cryoprotectant), the current impossible cryopreservation of chicken oocytes due to its telolecithal structure, while semen alone does not capture genes of mitochondria and the W sex-chromosome. Therefore, new effective cryopreservation methods for both male and female chicken germplasms, as well as new strategies for maintaining and using the stored cryopreserved materials for cost-effective gene banking are required. The methods and strategies developed will likely also benefit other poultry species and conservation of wild relatives. CRYOCHICK comprises a high level training program for Dr. Bernal and different coordinated actions performed by prestigious institutes from different countries and research fields promoting international collaboration, interdisciplinarity and transfer of top knowledge to the private sector. The European competitiveness will be reinforced by addressing, with the highest level of knowledge, important global scientific and societal concerns such as maintenance of biodiversity and food security, both serious threatened by climate change.

Mots clés : cryopreservation, chicken, supercooling, antifreeze proteins, nucleating proteins, sperm, fertility, artificial insemination, pgcs, gonadal germ cells, embryos, vitrification

Participants :
- Nemzeti biodiverzitas- es genmegorzesi kozpont (Hongrie) — Partner, associated partner, Recherche, subvention : 0.0 €
- Wageningen University & Research (Pays-Bas) — Coordinator, beneficiary, Recherche, subvention : 203464.32 €
- Université d'Édimbourg (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet QuantGraph (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

One of the greatest successes of physics is the quantum field theory (QFT), with its stunningly accurate predictions. These are usually obtained by drawing so-called "Feynman diagrams". In this fellowship, I will develop new methods to obtain and manipulate these diagrams, achieving the following two objectives:  The first objective is a generalization of the Batalin-Vilkovisky approach to QFT using ideas from symplectic geometry and operads. The outcome will be a category of operadic Batalin-Vilkovisky theories and generalized Lagrangian relations between them, together with a set of interesting examples and applications to topological recursion. This will be a common generalization of the ideas of Barannikov on modular operads and Batalin-Vilkovisky formalism, and the ideas of Ševera on the quantum odd symplectic category. The second objective is to develop computer assistant for graphical calculus, or an "intelligent paper". This will be an app allowing the user to perform calculations with string diagrams for symmetric and braided tensor categories, bringing the formalism introduced by Penrose to the computer screen.  This will be a strongly interdisciplinary fellowship, combining mathematical research related to physics with applied computer science. Strong dissemination activities are planned to promote the app for graphical calculus, including a secondment at the School of Informatics at the University of Edinburgh, a leading research institute for quantum computing.  At the Departments of Mathematics and Physics of the Humboldt University in Berlin, I will benefit from the active scientific environment and the expertise of my supervisor and co-supervisor. Their mentoring and the fellowship will develop my skills in mathematics, teaching, event organization and dissemination, allowing me to establish myself as a researcher.

Mots clés : quantum field theory, quantum algebra, symplectic geometry, computer assisted algebra, category theory

Participants :
- Université Humboldt de Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 217965.12 €
- Université d'Édimbourg (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet EATTS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

In the proposed project "Entanglement-Assisted Thermoelectric Transport in Quantum Systems" (EATTS), the European Researcher Dr. Nahual Sobrino, together with Prof. Rosario Fazio at the International Centre for Theoretical Physics (ICTP), will collaborate with international research groups to unveil innovative thermoelectric properties that hold transformative potential for sustainable energy technologies, quantum information science, and the development of advanced quantum materials. The project's objectives will concentrate on the exploration of thermoelectric phenomena mediated by entangled electrons across a variety of quantum systems. A comprehensive theoretical and computational framework will be established to explore and enhance thermoelectric performance in systems where electron entanglement plays a pivotal role. Cutting-edge calculations will be performed using sophisticated theoretical frameworks, including Quantum Master Equations (QME), Hierarchical Equation of Motion (HEOM), and quantum information techniques. This will guide to elucidate the intricate relationship between entanglement, system-environment interactions, and thermoelectric performance in Double Quantum Dots (DQD) and Cooper Pair Splitters (CPS) systems. Moreover, the project aims to extend the scope of Density Functional Theory (DFT) to access to entanglement measures in transport scenarios through the development of extensions of iq-DFT. This will facilitate a more efficient computational description of thermoelectric phenomena under the influence of entangled electrons. Additionally, the thermoelectric and entanglement characteristics of multiple diatomic molecules will be investigated by mapping the system into effective Hamiltonian models. The computational framework developed will advance our understanding and serve as a guide for experimental endeavors by selecting promising materials and parameter regimes.

Mots clés : thermoelectric phenomena, entanglement, density functional theory, 

Participants :
- Organisation des Nations unies pour l'éducation, la science et la culture (France) — Coordinator, beneficiary, Recherche, subvention : 188590.08 €
Projet NANOINHALE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Infectious respiratory diseases such as COVID or tuberculosis (TB) still have devastating effects on population health. While the development of potent vaccines has drastically reduced infection rates for some diseases, medicinal drugs remain a corner stone of treatment. Respiratory drug delivery via inhalation is considered an ideal way to directly target the site of infection in the lung. However, suitable functional polymeric drug carriers meeting all clinical and pharmaceutical requirements are rare. NanoInhale aims to develop novel polypeptide nanoparticles with mucus penetrating and cell targeting properties suitable for nebuliser-based drug administration to the lower respiratory tract with a project proof-of-concept demonstration for tuberculosis (TB) up to in vitro level. This clinically informed project is placed at the intersection of polymer chemistry, biomaterial science, and drug delivery and further expands into the fields of medical devices and nanomedicine. The project involves academic and clinical collaborators active in the fields of polymer and pharmaceutical science as well as TB Immunology. The applicants’ expertise in translational polymeric biomaterials in medical applications will be further enhanced by a unique training programme in scientific and complementary skills. NanoInhale’s impact goes beyond the studied area of TB as this platform technology is envisaged to be exploitable in other respiratory treatments. Project results will be communicated to the scientific community as well as the public to create further awareness of the importance of combating infectious respiratory diseases.

Mots clés : polypeptides, polymers, nanogels, drug delivery, tuberculosis

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199694.4 €
Projet SPECS-OA (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Osteoarthritis (OA) affects ~108 million Europeans, has a rising prevalence, and is one of the top causes of disability. Exercise has proven to improve outcomes, yet only 33% of patients adhere to physical activity guidelines. Social Prescribing (SP) is a public health strategy that connects healthcare with community resources, addressing non-clinical needs such as physical activity and social isolation. Despite its potential, little research has explored SP in OA care. SPECs-OA aims to investigate whether SP can be integrated into OA care pathways, and if so how, through the following specific research objectives: 1) To conduct a rapid systematic review evaluating the effectiveness and cost-related outcomes of SP for chronic conditions; 2) To evaluate the impact and implementation of SP in OA care using an innovative multi-level mixed-methods realist approach, with patients and professionals, exploring how SP works, for which patients, and under what conditions; 3) To co-design an international, transferable framework to guide SP integration in OA care, using World Café methodology, in collaboration with patients, healthcare professionals, and SP stakeholders. SPECs-OA will advance knowledge on the evidence of SP effectiveness for chronic conditions, being to the best of our knowledge the first study to analyse the impact of SP in people with OA. SPECs-OA framework will provide a SP guide for health professionals and OA patients, and influence health policies, to ultimately optimize individual and organizational outcomes. To undertake SPECs-OA, I will relocate to the Royal College of Surgeons in Ireland, where I will receive tailored training on SP, implementation science, realist evaluation, health economics, and collaborative methodologies. This will enhance my expertise in the implementation of innovative interventions with real-world meaning, preparing me to lead future research and contribute to public health initiatives in chronic disease management.

Mots clés : osteoarthritis, social prescribing, realist evaluation

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 252728.64 €
Projet PancmiR (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Pancreatic tumours are among the most aggressive, and are associated with the lowest survival rates. The main reason of this is their characteristic dense fibrotic stroma, which creates a perfect environment to promote cancer progression. To accurately mimic the Extracellular Matrix (ECM) is challenging, but is essential to understanding the interaction that occurs during malignant transformation. KRAS mutation is the most frequent alteration in pancreatic cancer. Micro(mi)RNA-143-3p and miRNA-216b have been shown to decrease KRAS gene expression and suppress tumour cell growth. My overarching Aim is to generate a 3D model of pancreatic cancer in which I can test the ability of a miRNA-activated scaffold to suppress tumour growth and facilitate local delivery of miRNA (miRNA-143-3p and miRNA-216b) that downregulate KRAS expression. Prof. Fergal O’Brien’s group in Royal College of Surgeon in Ireland has an extensive experience with development of biomimetic scaffolds to recreate the tumoural ECM and activating scaffolds to release therapeutic molecules (e.g., miRNAs). Using techniques established in his group, I will develop a 3D collagen-based scaffold that recreates the structure of pancreatic tumour ECM and then utilise this form as miRNA-activated scaffolds that will be used as local delivery systems in a radical new treatment for this disease. I will be supervised by Prof. O’Brien, and he will guide my Career Development Plan. I will develop complementary skills in project management, leadership, entrepreneurship, commercialisation, dissemination, and profile enhancement. Acquiring advanced research competences and complementary skills, I will maturate as an independent scientist, enhancing my professional visibility, capacity, and competitiveness in the field of biomaterials. This Fellowship will significantly contribute to the achievement of my long-term career goal, which is becoming an independent scientist leading my own biomaterials research group.

Mots clés : scaffolds biomaterials collagen mirna pancreatic cancer nanomedicine

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199694.4 €