Projet FarmEVs (Horizon Europe, appel à projets 2022)
Action : Staff Exchanges
Panel : Chemistry
Statut du projet : SIGNED

Extracellular vesicles (EVs) are biomembrane-enclosed structures that are ubiquitously secreted by living cells. EVs, by transferring proteins, lipids, nucleic acids and other molecules to neighbouring or distant cells contribute to tissue homeostasis and have roles in many physiological and pathological processes. In this context, plant-derived vesicles started to receive attention as valid alternatives to EVs released by mammalian cell. Going beyond the state-of-the-art and relying on a highly interconnected approach, FarmEVs project will setup a vegetable-based system for the massive production of vesicles and explore them as high-value ingredients for plant and human health. This will be achieved through the isolation and engineerization of EV-like nanovesicles from organically grown crops. Plant derived-vesicles will be exploited for sustainable agriculture with the help of an organic farm in Finland and an agricultural university in Egypt. Moreover, we will setup plant cell cultures for EV farming and by applying emerging biotechnology we will develop EV-based solutions to increase the viral resistance of plants and the pro-symbiotic activities in legume crops. To achieve the goals, a multidisciplinary consortium with the participation of 8 partners from universities, research centres, an SME and an organic farm from 6 countries has been created with the integration of a broad expertise ranging from EV research, biomembrane modelling, plant genetics, plant physiology, virology, molecular farming, engineering and agriculture. This project will strengthen the already existing collaborations, create new ones and provide a solid cornerstone for further research efforts of the consortium participants after the ending of the project. An ambitious staff exchange programme for the transfer of scientific and transferable skills, dissemination and outreach activities was implemented into the scientific plan.

Mots clés : extracellular vesicles, organic farming, nanovesicles, medical physics, innate immunity and inflammation, microfluidics

Participants :
- Damanhour University (Égypte) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Immunoveg societa' a responsabilita' limitata (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 36800.0 €
- Conseil national de la recherche (Italie) — Coordinator, beneficiary, Recherche, subvention : 404800.0 €
- Lehtosarvi ky (Finlande) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 161000.0 €
- Université de Ljubljana (Slovénie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 202400.0 €
- Institut polytechnique national (Mexique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Naples - Frédéric-II (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Kyung Hee (Corée du Sud) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université d'Oulu (Finlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 216200.0 €