Projet ECMED (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network function has advanced considerably in recent years, its full translational potential has yet to be realised. There is growing evidence for a major role of the ECM in epilepsy including the association between ECM protein mutations and epilepsy, changes in the ECM and associated proteins during the development of epilepsy and the strong association between the ECM and brain diseases associated with epilepsy including stroke, traumatic brain injury, neurodegeneration and autism. This proposal brings together considerable expertise from academic and industry partners in the biology of the ECM with experts in epilepsy research. This, therefore, represents a truly collaborative effort to determine not only the role of the ECM in the development of epilepsy but also novel approaches to treat and to prevent epilepsy. The academic partners will focus on specific research questions, whilst the industrial members will provide diagnostic, treatment and advanced research tools. The project has a strong translational theme and the combination of basic and translational science will be of great benefit for the training of young researchers. Trainees will be exposed to courses, workshops, joint research meetings and inter-laboratory visits. The focus of the training programme is on expanding knowledge and the application of such knowledge to address pertinent question relevant to the diagnosis, prognosis and treatment of epilepsy, so providing an ideal insight into translational neuroscience.

Mots clés : extracellular matrix  ecm, epileptogenesis, neuronal circuits, therapeutics, anti epileptogenic

Participants :
- Italian Institute of Technology (Italie) — Partner, beneficiary, Recherche, subvention : 516122.64 €
- University of Antwerp (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 250560.0 €
- Leibniz Association (Allemagne) — Partner, beneficiary, Recherche, subvention : 249216.48 €
- German Center for Neurodegenerative Diseases (Allemagne) — Partner, beneficiary, Recherche, subvention : 498432.96 €
- Polish Academy of Sciences (Pologne) — Partner, beneficiary, Recherche, subvention : 224137.44 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Iproteos sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 247872.96 €
- University of Eastern Finland (Finlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 269145.36 €
- Aix-Marseille Université (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262875.6 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 255374.28 €
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €