Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MicroCoFE (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Tropical reef-building corals live in a dynamic environment with fluctuating exposure to solar light and seawater flow. It has long been assumed that corals interact passively with the surrounding seawater via a so-called diffusive boundary layer (DBL), which is a thin (~0.1-1 mm) layer of water located at the immediate surface of the coral, wherein molecular diffusion is the dominant transport mechanism for gases and solutes. The DBL can thus be an important regulating mechanism for coral metabolism. However, the recent discovery that some corals possess the ability to enhance mass transport across and within the DBL via the generation of vortices caused by the beating of epidermal cilia indicates a more complex and active control of mass transfer, albeit the importance for coral ecophysiology and stress responses remains unexplored. In this project, I will: i) develop and apply novel imaging approaches (using optical sensor nanoparticles for oxygen and pH in combination with a particle imaging velocimetry system) for studying flow and mass transfer at the coral-seawater interface; and ii) use the novel imaging techniques together with other microenvironmental sensing approaches (microsensors and optical coherence tomography) to study how ciliary beating affects coral ecophysiology. This will generate novel insights to fundamental questions of how corals exchange solutes with the surrounding seawater, how these basic processes are affected by environmental perturbations (of e.g. temperature, oxygen level and pH), and the relationship between these external processes and the internal structural heterogeneities of the coral tissue. The project will be conducted at the Marine Biology Section of the University of Copenhagen, where all experiments will take place under the supervision of Prof. Dr. Michael Kühl and complemented by a secondment at the Max Planck Institute for Marine Microbiology (Germany) and a short visit to the Graz University of Technology (Austria).

Mots clés : coral, flow, ecophysiology

Participants :
- Société Max-Planck pour le développement des sciences (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet MAP-MISINFO (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

MAP-MISINFO is a proposal for a two-year European MSCA Fellowship at the University of Copenhagen (UCPH), within the Department of Communication (COMM). It proposes examining the intersection of misinformation, as a growing threat to democracy, and media research practices aimed at understanding information dissemination. As media research approaches are a key way to understand and potentially address misinformation, it is vital that media scholarship better account for gaps in practice—for example, around under-researched contexts such as rurality and radio. Another prevalent but understudied gap is how qualitative inquiry can be used to in conjunction with common practices in ‘counting or categorizing’ instances of misinformation online; such approaches better consider the manifold ways societies navigate between facts and fabrications—what sociotechnical systems and contexts might allow misinformation to thrive or be combatted. The MAP-MISINFO project will work towards filling both types of gaps through a two-pronged, interrelated research design. First, the project will engage in an empirical case study, mapping a misinformation-related topic as it moves through the open web and region-specific media ecosystems. The region of focus will be the rural, conservative, relatively homogeneous US state of Utah. This case study will serve to inform (and be informed by) the other prong of MAP-MISINFO: a mapping and analysis of common media research tools used in examining misinformation. This second objective of the project entails carefully curated workshops of media scholars and publication overviews. The project will generate a public-facing website, media appearances, peer-reviewed publications, a report for general distribution, and a special issue of a top Communications journal. The host institution, UCPH, is uniquely positioned to provide methodological and theoretical guidance. MAP-MISINFO will also contribute to establishing my international academic career.

Mots clés : misinformation, digital methods, media studies, web sphere analysis, mixed methods, qualitative inquiry, rurality, broadcast media, mormonism, alternative media ecosystems, evangelical media

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 230774.4 €
Projet Beyond the BBB (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Alzheimer’s disease (AD) is a neurodegenerative disease affecting the aged population and is projected to increase 3-fold in the next 30 years. Treatment options in AD are limited due to complex pathological processes and the blood-brain barrier (BBB), which restrict entry molecules into the brain. A finding in AD is the loss of cholinergic neurons. Tropomyosin receptor kinase A (TrkA) and its substrate, the nerve growth factor (NGF), are involved in neuronal survival and have been evaluated in small clinical trials as a therapeutic intervention in AD. Advances in BBB shuttling methods, in which antibodies and enzymes can be transported over the BBB, make NGF a possible treatment option in AD. Within this proposal, I will develop novel methods for the delivery of NGF into the brain. Two different approaches for BBB delivery of NGF will improve the success rate. In one approach, NGF will be delivered into the brain by transferrin receptor (TfR)-mediated transcytosis. NGF will be chemically conjugated to a TfR binding antibody using a linker that selectively and quantifiably can release NGF in its native form in the brain, ensuring retained biological activity. An alternative approach, BBB will be opened with focused ultrasounds allowing passage of NGF into the brain. Positron emission tomography occupancy studies with [18F]TRACK, a TrkA selective tracer, will be used to evaluate in vivo binding of NGF to TrkA. The above-described BBB transport methods for NGF will be evaluated in long-term therapeutic study using 5xFAD mice. Pharmacodynamic readouts will be changes in brain amyloid-beta levels, neuroinflammation parameters and improved memory and cognitive functions. In this project, I will expand my knowledge in BBB delivery of macromolecules, learn new radiolabeling techniques from a world-leading radiochemist, and novel develop the necessary skills to take my career to the next level.

Mots clés : blood brain barrier transport, transferrin receptor, alzheimer s disease, tropomyosin receptor kinase a, nerve growth factor, positron emission tomography

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet REWARD (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Antibiotic resistance is a major global public health threat. There is a growing concern that aquatic environments, which are in contact with the human microbiome in both urban and rural settings (drinking water, recreational bathing, crop irrigation), may serve as a reservoir of antibiotic resistance genes (ARGs) that might disseminate to human pathogens through horizontal gene transfer (HGT). However, the magnitude of this dissemination risk and the mechanisms involved remain unknown. REWARD (REsistance to antibiotics in Water: Assessment of the Risk of Dissemination) aims to identify the major drivers of human health risk and establish biomarkers for the monitoring and mitigation of antibiotic resistance dissemination in aquatic environments. REWARD will fill current knowledge gaps on the prevalence and ARG content of mobile genetic elements (MGE, plasmids and bacteriophages) in the aquatic environment, the frequency and genetic responses driving ARG HGT from these MGE to human pathogens, the impact of environmental and anthropogenic stresses on MGE prevalence and HGT frequency and the magnitude of the ARG dissemination risk to human pathogens in aquatic ecosystems. River and sea water from 8 aquatic ecosystems across Europe will be analyzed. The main drivers (MGE and genes) of ARG dissemination to fluorescent-labelled human pathogens added to surface waters will be determined using a combination of flow cytometry, last-generation metagenomic and metatranscriptomic sequencing technologies and newly-developed bioinformatic approaches for the reconstruction of MGE from metagenomic reads. Physiochemical and anthropogenic variables will be characterized in river water samples to establish dose-response links between anthropogenic and environmental stresses (including stresses linked to climate change) and ARG HGT in aquatic environments. Finally, a mathematical model to quantitively predict ARG dissemination risk will be developed using the data generated in REWARD.

Mots clés : antibiotic resistance dissemination, molecular ecology, health risk assessment, bioinformatics, microbial ecology, horizontal gene transfer, freshwater microbiology

Participants :
- Université nationale de Singapour (Singapour) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 263393.28 €
Projet LEARN-UCJ (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Latin America (LA) stands out as the world's most urbanized, unequal, and one of the most disaster-prone regions. Its vulnerability to climate change is rapidly increasing, disproportionately affecting impoverished communities in an intersectional manner. These communities contribute the least to Greenhouse Gas Emissions, do not benefit of economic growth, and are excluded from policy making. Climate justice movements advocate for collective action against such injustices.  LEARN-UCJ seeks to unpack the potential of social learning for urban climate justice (UCJ) policy making and urban planning. LEARN-UCJ adopts a transdisciplinary approach, fostering knowledge co-production among stakeholders. The methodology is participatory, ensuring diversity and network-building. It employs an ethnographic methodology, collecting data through interviews and on-site observations. The project will focus on Bogotá (Colombia) and Mexico City (Mexico).  LEARN-UCJ incorporates training and knowledge transfer objectives. Under the guidance of Dr. Rodríguez-Labajos at UPF, I will receive training in environmental justice and intersectionality. This training will enhance my skills in QDA, leadership, written and oral communication. I will transfer my expertise in participatory strategies, LA policies, and governance. LEARN-UCJ plays a significant role in realizing my vision of becoming a professor, researcher, and a policy advisor for climate justice.  To maximize outcomes and impacts, LEARN-UCJ will undertake dissemination and exploitation activities. To ensure broad access to outcomes, two open-access papers will be published. All communication activities aim to raise awareness about UCJ among target groups. A major achievement of LEARN-UCJ will be the establishment of the Alliance for Climate Just Cities (ACJC), a collaborative network for social learning and climate justice. This network will contribute innovative ideas to inform the development of more equitable policies.

Mots clés : climate injustice, climate policy, urban planning, disaster risk management, intersectionality, participation, transdiciplinary knowledge co production, degrowth, decolonial, social movements

Participants :
- Université Pompeu Fabra (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
- Université de Padoue (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PLASTIFLY (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The management of plastics, a persistent environmental challenge due to their durability, necessitates innovative solutions. While Black Soldier Fly (BSF) larvae demonstrate potential as a bioremediation agent for organic waste, their capacity for plastic degradation remains limited. This study proposes enhancing the plasticolytic capabilities of BSF larvae through genetic engineering, specifically by introducing plastic-degrading enzymes using CRISPR/Cas9 technology. To overcome the challenges associated with low gene delivery efficiency in insects, we propose employing chitosan-based nanocarriers. These carriers offer biocompatibility, biodegradability, and protection for genetic material. Integrating magnetic nanoparticles into these carriers enables magnetofection, improving gene delivery precision and efficacy. By genetically modifying BSF larvae to degrade plastics, we aim to develop a sustainable, eco-friendly approach to plastic waste management, reducing reliance on harmful chemicals and minimizing environmental impact. This research has the potential to expand beyond conventional plastics, contributing to comprehensive waste management strategies.

Mots clés : chitosan nanoparticles, plastic degradation, black soldier fly

Participants :
- Université de l'Insubrie (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
- Conseil supérieur de la recherche scientifique (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Padoue (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet iINGUT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

In 2020, cancer affected 2.7 million people in the European Union and claimed 1.3 million lives, including more than 2,000 young adults. If immediate action is not taken, cancer cases are expected to increase by 24% by 2035. This project aims to accelerate the development of new cancer therapies. Immunotherapy, particularly through immune checkpoint inhibitors (ICIs), stands out as a highly promising treatment, utilizing the body's own immune system to target and destroy cancer cells with greater precision and fewer side effects than other approaches. Yet, the effectiveness of ICIs varies significantly between patients and tumor types. In this regard, the hosting laboratory has been on the frontline in studies that revealed the influence of the individual gut microbiome on the heterogeneity in ICIs response, opening new avenues for improving treatment outcomes. iINGUT (immunotherapy on an INtegrated GUt microbiome and Tumor on-chip) is a novel platform designed to study the modulatory role of the gut microbiome on the response of solid tumors to therapy, and in particular to ICI. iINGUT consists on a mechanically active microfluidic system integrating the complexity of multicellular structures and functions of the human intestine with a module dedicated to patient-derived tumor models. The entire platform can be personalized with fecal, blood, and tumor samples from the patient, providing a time- and cost-effective tool for predicting treatment outcome and developing novel immunotherapy-based strategies tailored for specific groups of patients. iINGUT will enable me to apply my engineering background to complex biological questions, facilitating my growth as a researcher and advancing my interdisciplinary expertise.

Mots clés : microfluidics, immunotherapy, organ on chip, gut microbiome, tumor microenvironment

Participants :
- Istituti di Ricovero e Cura a Carattere Scientifico (Italie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 193643.28 €
- École polytechnique de Milan (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet GREAM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Glycyl radical enzymes (GREs) are one of the most prominent biological catalysts in both strict and facultative anaerobes. They are responsible for a broad range of radical-based chemistry and catalyse reactions involved in diverse metabolic pathways such as acid fermentation, DNA synthesis and the anaerobic metabolism of pollutants. GREs are activated by members of the S-adenosylmethionine (SAM) radical family. Activation of GREs requires the formation of a protein-protein activation complex with the small GRE-AE. All known structures of GREs show that a major conformational change very likely occurs during the glycyl radical generation upon interaction with the GRE-AE. Only a structure of a GRE:AE holocomplex would shed light on the unprecedented conformational changes involved in GRE activation. Glycyl radicals and iron-sulfur clusters are extremely oxygen sensitive, rendering the proteins challenging to work with.  GREAM will narrow a significant knowledge gap by studying the anaerobic class III RNR natural fusion (NrdD:NrdG). In order to study the mechanism of activation, GREAM will use an integrative research approach combining biochemical, biophysical and cryo-EM – assisted by X-ray crystallography.  With my experience in anaerobic protein characterisation and crystallisation, I will join the Fontecave lab to build up on their experience in spectroscopic characterisation of oxygen-sensitive protein complexes and achieve the first aim or GREAM. During a secondment in the Logan lab, who are expert in structural characterisation of aRNRs and have a long lasting collaboration with the host, I will solve the anaerobic cryo-EM structure of the NrdD:NrdG holocomplex and achieve the final goal of GREAM. This newly established international collaboration will permit combining integrative approaches to successfully answer all GREAM’s questions and allow me to acquire invaluable experience in my future career.

Mots clés : glycyl radical enzyme, x ray diffraction, cryo em, ribonucleotide reductases, oxygen sensitive enzymes, dna synthesis, protein complexes

Participants :
- Université de Lund (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Collège de France (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet COMPASS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The COMPASS project, acronym for "Cavity cOntrol of quantuM PhAseS in nanophotonic cavitieS," delves into the theoretical exploration of inducing and controlling superconductivity and other many-body phases using nanophotonic cavities. Situated in the field of cavity quantum-electrodynamics (cQED), COMPASS leverages the strong-coupling light-matter interactions characteristic of hyperbolic phonon polariton (HPP) nanophotonic cavities. Offering a significant advancement over traditional Fabry-Pérot cavities, HPP cavities promise unprecedented control over electronic structures, potentially deepening our understanding of exotic superconductivity and introducing novel quantum states of matter. This project necessitates the development of novel theories for strongly correlated materials embedded in nanophotonic cavities, by merging solid-state, quantum optics, and many-body physics. The action will be carried out by Dr. Gian Marcello Andolina at Collège de France under the supervision of Dr. Marco Schirò. The project integrates the Researcher's advanced expertise in quantum nanophotonics and solid state physics with the Host's mastery of many-body theory. The multidisciplinary environment of the Hosting Institution will be pivotal for the success of the Action for the growth of the Researcher.

Mots clés : light matter interaction, superconductivity, cavity quantum electrodynamics, nanophotonic cavities, nonequilibrium systems, strongly correlated systems, quantum phase transitions

Participants :
- Collège de France (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet DEEP (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Energy poverty households face insufficient access to affordable and reliable energy services, which can lead to adverse health effects and risky coping strategies. The EU made energy poverty a policy priority in the Clean energy for all Europeans package in 2019, and one of the objectives is to address energy poverty by promoting energy-efficient behaviors. However, intervening in users' behavioral decisions is difficult as it requires a deep understanding of the behavior patterns and a rational explanation of the behavior mechanism. This project will address a key question in energy poverty research: can behavior pattern analytics facilitate the decision-making of energy poverty? Hence, the main objective is to assess if data-driven analytics of energy use patterns can provide insight into behavioral interventions to address energy poverty. Through this project, the applicant plans to use three progressive analytics tasks to answer the question: (i) Identify the behavior patterns of energy consumption (Descriptive Analytics). (ii) Reveal potential cognitive biases that impede high energy efficiency (Prescriptive Analytics). (iii) Explore policy interventions against cognitive bias (Prediction Analytics). The project will analyze user-level data through Graph Data Modeling to quantify energy use patterns and behaviors, overcoming the limitations of the traditional method relying only on descriptive statistics. Host and secondment will complement the interdisciplinarity of the project from the perspectives of energy behavior (behavioral science) and cognitive visualization (computer science) respectively. The project will facilitate the applicant's long-term research goals with interdisciplinary knowledge, enhancing the development of his career as an independent researcher. Potential beneficiaries are energy poverty households and energy stakeholders. The proposal is in line with the Sustainable Development Goals (SDGs) and objectives of the H2020 program.

Mots clés : energy efficiency, energy poverty, data mining, behavioral intervention, decision making

Participants :
- Université technique du Danemark (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Helmholtz-Gemeinschaft (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 130385.52 €