Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet COR1-TCELL (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Harnessing T-cell homeostasis is important for cancer immunotherapy as well as anti-microbial immunity and the prevention of autoimmune disorders. T-cell homeostasis in peripheral lymphoid organs is known to be regulated through interleukin-7-mediated cytokine signalling and via T-cell receptors recognising self-peptides loaded on major histocompatibility complex. However, recent results suggest a requirement of a third pathway at low T-cell density such as in newborns that depends on the WD repeat protein family member coronin 1, the mechanism of which is unknown. The objective of this proposal is to elucidate the molecular mechanism of coronin 1-dependent sensing of low cell density that contributes to peripheral T-cell homeostasis. In preliminary work, I established a co-culture assay of T cells and antigen presenting cells that recapitulates coronin 1-dependent T-cell survival at low cell density. In addition, I found that adoptive transfer experiments reconstituted the coronin 1-dependent peripheral T-cell expansion in a lymphopenic environment in vivo. To delineate the molecular mechanisms underlying this cell density-dependent signalling mediated by coronin 1, I will combine the originally established in vitro and in vivo assay systems with state-of-the-art single-cell RNA sequencing, in addition to biochemical analysis utilising mass spectrometry. This will identify the signalling pathways and the molecules involved in this density-sensing mechanism. Finally, ad-hoc ablation of coronin 1 using a newly established inducible knockout mouse will reveal the role for coronin 1 in the maintenance of peripheral T cells after successful expansion at post-neonatal stage. The results from this project will define a hitherto uncharacterized density-sensing pathway required for T-cell homeostasis. Furthermore, the fellowship will potentiate my career opportunities as it allows to explore cutting-edge biology and technologies in a highly stimulating research environment.

Mots clés : t cell homeostasis, cell density, lymphopenia induced proliferation  lip, co culture system, single cell rnaseq, inducible knockout

Participants :
- University of Basel (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175419.6 €
Projet InjectCHA (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Having recently returned to the EU following Postdoctoral training in Australia, I hope to work as a MSCA Reintegration Fellow to tackle a devastating clinical orthopaedic challenge for which there is currently no effective treatment. Specifically, bisphosphonate (BP) associated atypical femoral fractures (AFFs) in osteoporotic patients which are associated with excruciating pain and high levels of morbidity and mortality. The scientific goal of this proposal is to integrate my tools in bone tissue engineering with the advanced drug delivery expertise of Prof. David Brayden’s group at University College Dublin (UCD) to develop a novel injectable therapeutic scaffold as a non-invasive treatment for AFFs. This proposal outlines an innovative research project that aims to implement a revolutionary strategy utilising Teriparatide (PTH-(1-34)) to target BP remobilisation away from AFF site and induce bone repair. In addition, a tissue engineering strategy will be employed that combines a regenerative, load bearing biomaterial for controlled local delivery of PTH(1-34) as a pioneering advance for AFF treatment. As a newly appointed academic, the training objective of this grant is to attain the requisite scientific and complementary skills to successfully develop an independent research programme. This will be achieved through the expert supervision and input of Prof. Brayden and backed up by colleagues in the lab and UCD staff training activities. In addition, by managing the project, I will further develop skills relating to planning and reporting, financial management, dissemination, patent filing and commercialisation. I will also avail of opportunities to recruit and supervise students on this project or related works. In summary, this grant will provide invaluable help to establish an independent research niche in active and emerging research fields, while equipping me with the skills needed as a newly appointed lecturer embarking on an independent research career.

Mots clés : osteoporosis, collagen scaffold, bone tissue engineering

Participants :
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 87933.0 €
- National University of Ireland (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 87933.0 €
Projet Sensor4Diabetes (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Health and well-being has been one of the kHealth and well-being has been one of the key societal and grand challenges identified in EC Research and Innovation programs. Diabetes is one of the most prevailing chronic health problems across Europe and worldwide. Diabetic patients experience painful blood glucose testing in daily basis which is highly inconvenient. Replacement of blood testing with non-invasive methods would bring a paradigm shift in diabetes management. Human exhaled breath consists of several traces of volatile organic compounds (VOCs) known as “breath marker”. The presence of increased amount of acetone, ethanol and methyl nitrate has been confirmed in diabetic breath by various sophisticated techniques which are not suitable for routine clinical practice or domestic use due to their non-portability, complexity, bulk-size and high costs. Metal oxide sensors have considerable potential in detecting VOCs in exhaled breath. For VOCs analysis in breath requires high sensitivity together with high selectivity. The aim of this project is to develop hybrid sensor for analyzing VOCs in breath from 1D metal oxide nanostructures functionalized with different catalytic nanoparticles. Both impedometric and photonic properties of the sensors will be measured in presence of synthetic healthy and synthetic diabetic breath. The 1D metal oxide nanostructures on sensing platform could provide high surface-to-volume ratio for surface adsorption/desorption of gas molecules together with excellent electronic and optical properties. The addition of catalytic nanoparticles on the surface of 1D nanostructures will enhance the sensitivity and response time towards VOCs by lowering the oxidation energy, increasing the catalytic surface area and catalytic activation of gas molecules. It is expected that adoption of hybrid sensing principle will enhance the selectivity towards individual VOCs which is essential for the development of highly effective diabetic breath analyzer.

Mots clés : diabetes detection, breath analysis, gas sensors, metal oxides, one dimensional nanostructures

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet Global eHealth (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Healthcare in low and middle income countries (LMICs) is undergoing rapid change and addressing a widening range of diseases. The needs of the disadvantaged, underserved and remote communities are increasingly recognized, and there is an emphasis on disease surveillance, measuring and improving quality of care and reducing preventable adverse events. The timely and accurate collection, analysis and use of health information is essential for all these initiatives, and eHealth systems are increasingly seen as essential. The Fellow has led several multi-national eHealth projects in LMICs for over a decade including electronic medical record systems (EMRs). In 2004 he co-founded and co-leads the OpenMRS open source EMR system now deployed in more than 40 LMICs, and it’s initial roll out in Rwanda, now in over 300 clinics. He has led or co-led 18 innovative evaluation studies of eHealth and mHealth systems demonstrating impacts on clinical care processes and laboratory data access including the first randomized controlled trial of a lab information system in a LMIC to show clinical benefit. The objectives of this fellowship are to (1) evaluate with an RCT the clinical and health service impacts of an eHealth systems in an LMIC, and to evaluate system performance and costs. (2) improve the quality and use of clinical data from EMR systems for care and research in both the EU and in LMICs, focusing on heart disease and diabetes and (3) create a Global eHealth group at Leeds University to strengthen European and Global capacity in eHealth development, implementation and evaluation. The Fellowship builds on the innovative and internationally recognized work of the Fellow, in collaboration with Professor Jeremy Wyatt a world leading expert on eHealth evaluation at the University of Leeds, UK. It will provide a unique opportunity for the Fellow to re-integrate into Europe, make a major step forward in his skills and leadership in eHealth, and achieve a senior career position.

Mots clés : global ehealth, evaluation, developing countries

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet TiGER (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Heart disease is a staggering clinical and public health problem and the leading cause of death for both men and women in Western countries. The underlying pathomechanism of nearly all aetiologies relates to altered contractility and cardiac tissue tension but also gene expression changes and epigenomic remodelling. Within the sarcomere, the fundamental contractile unit in striated muscle, the giant protein titin is the major source of cardiac passive tension. Since sarcomeres are connected to the nucleus, I hypothesise that titin passive tension is transmitted to the nucleus and sensed by the mechano-sensitive nuclear lamina, affecting chromatin structure and gene expression, similar to cytoskeleton passive tension in nonmuscle cells. I will test this hypothesis in human cardiomyocytes derived from induced pluripotent stem cells (hiPSC-CMs) with either a low or high titin-derived passive tension by editing the titin gene locus. I will also investigate whether changes of titin tension affect sarcomere-resident chromatin remodellers: Smyd1, Smyd2, and HP1γ. Combining fluorescence and super-resolution imaging with chromatin-immunoprecipitation sequencing and RNA sequencing, I will delineate a comprehensive map of titin-derived epigenetic remodelling in hiPSC-CMs. The TiGER project will dissect a complex biophysical mechanism leveraging on hiPSC-CMs as they represent an exceptional platform to unveil human cardiac-specific phenomena that require extensive gene editing, culture, and imaging. As titin-derived passive tension changes during development, physiology, and disease, TiGER’s results could have major implications for cardiac pathophysiology and could unlock future compelling research avenues. I will explore this novel role for titin as an epigenetic remodeller under the supervision of Prof. Dr. Gotthardt, a world-leading expert of cardiac mechanotransduction and titin at the Max Delbrück Center (MDC) in Berlin.

Mots clés : mechanotransduction, titin, sarcomere

Participants :
- Max Delbrück Center for Molecular Medicine (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 174806.4 €
Projet SPEC (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Heat dissipation is one of the great challenges for microelectronic and information technologies, which is aggravated by the reduction of the transistor dimensions and the increases in packing density and amount of data. Therefore, beyond CMOS technologies and heat management strategies are important challenges that need to be faced for the sustainable development of a knowledge-based society. The exploration of spin-based devices exploiting novel mechanisms is one of the possible routes to explore. In particular, insulator spintronics has great potential. Since magnetic insulating materials (mostly transition metal oxides, TMO) can offer lower heat dissipation due to the absence of charge carriers and no Joule heating losses. Moreover, TMO can offer new functionalities due to the mutual interaction between several degrees of freedom: electronic, magnetic, lattice. One example; is the spin-lattice interaction which has recently gained increased attention. In this present proposal, I will explore magnon-phonon interaction effects in suitable magnetic insulating materials to investigate their potential for magnetic-field-controlled heat-rectification effects, as well as their contribution to spin-based thermoelectric conversion phenomena (spin Seebeck effect). I will carry out the proposed research under the supervision of Prof. F. Rivadulla at CIQUS-USC and secondments in the group of Prof. M. Klaui at JGU-Mainz, thereby making use of the complementary expertise and stablishing a collaborative work environment between both institutions. Moreover, the experience I acquired during the last 5 years in Prof. Saitoh laboratory at Tohoku University will be critical for the success of this project, placing me in an unbeatable moment to tackle this ambitious research.

Mots clés : spin caloritronics, magnon phonon interactions, magnetic oxides

Participants :
- University of Santiago de Compostela (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet HPOFHIC (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Heavy-ion collisions at collider energies are performed in order to produce and study QCD matter at high temperature, the quark-gluon plasma (QGP). Such an extreme state of matter is believed to have existed during the first microseconds after the Big Bang. The QGP and properties of strong force can be probed on a variety of length scales by jets, collimated sprays of particles originating from scattered quarks and gluons. The intent of this proposal is to study how high-energy quarks and gluons interact with the QGP and to better understand the mechanism of energy loss as they traverse the QGP. The investigators will focus on studies of jet substructure using contemporary substructure techniques as well as exploiting the role of flavour, jets size, and path-length dependence using new probes involving boosted objects. The project includes both experimental measurements and phenomenological investigations using existing models and their improvement.

Mots clés : heavy ion collisions, jet quenching, jet structure, jet substructure

Participants :
- Charles University (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 156980.64 €
Projet HepatoRiSK (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : TERMINATED

Hepatocellular carcinoma (HCC) ranks third in cancer mortality worldwide. In spite of this, effective treatment options are limited, partly due to a poor understanding of the molecular basis of HCC, which hampers development of targeted therapies. Recently, cancer genome sequencing mapped the landscape of genetic aberrations in HCC and unexpectedly revealed the kinase RSK2 as the most frequently mutated gene in the RAS-RAF-ERK pathway. I hypothesize that RSK2 is a tumor suppressor in HCC by acting as a feed-back inhibitor of the RAS-ERK pathway, since I find that RSK2 mutations are nearly all loss-of-function and that RSK2 loss potently activates ERK kinases in liver cells. The goal of this proposal is to functionally establish RSK2 as a novel and important tumor suppressor in HCC and identify the mechanism(s) whereby RSK2 may feed-back inhibit the RAS-ERK pathway to promote this cancer. This will be achieved through modelling RSK2 loss in liver cells in vitro and in mice. Among other approaches, I will model RSK2-dependent HCC development by mutating genes found co-mutated with RSK2 directly in the adult mouse liver via hydrodynamic tail vein injection of CRISPR/Cas9 reagents, which may cause HCC within months. I will subject cells and mouse models to mechanistic biochemical and phenotypic studies to elucidate the role and mechanism of RSK2 as a tumor suppressor in HCC. Key findings will be validated in HCC patient samples. The work will be performed in the context of my new role as assistant professor in the host lab, where I will be given formal supervision and management responsibilities. The work combines my postdoc experience in cancer genetics with my host´s beyond-state-of-the-art CRISPR/Cas9 genome editing techniques. Altogether, this fellowship has the potential to uncover new mechanisms for targeted intervention in HCC. Furthermore, it will be an important stepping stone for me towards an independent research career.

Mots clés : cancer biology, rsk2 kinase, crispr, cas9 genome engineering, hepatocellular carcinoma

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet BAIPFeOTC (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Here we propose the development of a new class of facial triad N,N,O ligands based on the bis(alkyl-imidazolyl)propionate (BAIP) architecture for the synthesis of bio-inspired mono-nuclear non-heme iron(II) complexes that have the ability to selective catalyze challenging oxidative transformations of organic compounds using oxidants like H2O2 or O2. Our specific aims will be: (i) To develop new sterically encumbered BAIP-ligands for the generation of highly reactive 1:1 Fe/ligand complexes, (ii) To develop ‘inverted amide’ versions of these ligands to generate Fe-amido complexes with low oxidation potentials for O2 activation, (iii) To study the reactivity towards oxidants (H2O2, O2) and the catalytic properties in challenging oxidation transformations (alkane hydroxylation, alkene cis-dihydroxylation) of the corresponding iron complexes. (iv) To carry out detailed mechanistic investigations on isolated and/or spectroscopically well-characterized iron complexes and intermediates that are involved in the reactivity of the new Fe-N,N,O complexes. The project will follow the so-called ‘synthetic analogue approach’, where small model compounds are developed to mimic the structural and functional features of metallo-enzyme active sites. In doing so, the model compounds may aid in the further understanding of metallo-enzyme reactivity and mechanism. At the same time the model compounds may be further developed into new synthetic catalysts. Carrying out this project within the Organic Chemistry and Catalysis (OCC) group at Utrecht University will place the candidate in the middle of the research activities of the Catalysis Centre Utrecht (CCU). This will allow the candidate to develop his knowledge and skills in the fields of bioinorganic chemistry and homogeneous catalysis, to further shape him for a future research career in the broader fields of molecular inorganic chemistry and molecular catalysis.

Mots clés : iron, oxidation catalysis

Participants :
- Utrecht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet N6MeA ChemSeq (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Herein, I propose to develop and adapt chemistry for the selective modification and tagging of N6-methyladenine (N6MeA) in the context of a DNA strand. Two promising chemical strategies will be applied, for which I have already established proofs-of-concept of efficiency and selectivity on DNA monomers (2'-deoxynucleosides and nucleotides). Once such a specific chemical labelling protocol has been optimised, I will use it to map N6MeA in genomic DNA with two different approaches: 1) by chemical pulldown of N6-methylated DNA fragments, sequencing of the enriched fragments, and alignment to a reference genome to generate a low-resolution N6MeA map. 2) By analysing the influence of the introduced tags and modifications on the PCR outcome and take advantage of their stalling of polymerases. The expected outcome is a first chemistry-assisted mapping of N6MeA. As for the chemical tagging of 5-formylcytosine (5fC) and 5-hydroxymethyluracil (5hmU), or oxidative and reductive bisulfite sequencing to sequence 5fC and 5-hydroxymethylcytosine (5hmC), all developed in the proposed host lab, it is expected to have a significant impact in the field. It will considerably facilitate the detection and mapping of genomic N6MeA in various species including mammals and humans, which is of tremendous importance to unravel the biological role of this DNA modification and identify novel biological as well as possible pathological pathways.

Mots clés : nucleic acids, n6 methyladenine, chemoselective reactions, epigenetics, sequencing

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet MIGRANTCHRISTIANITY (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

How do Evangelical migrants use religion and church-related networks to seek employment, pursue social mobility, construct respectability and resist racism? How do Evangelical churches become ‘brokers’ of socio-economic integration of their members thus stakeholders in immigration countries? These are the main questions that this project seeks to answer. MIGRANTCHRISTIANITY investigates how migrant men and women from Sub-Saharan Africa and Latin America make use of a minority religion in negotiating their social and economic integration in Europe. The project focuses on Ghanaian and Ecuadorian migrants in Italy and Spain. I investigate how migrants develop strategies of integration through the Evangelical churches and how such strategies are shaped by ethnicity, class, gender and age. I also look at how Evangelical churches act as ‘brokers’ of integration, in relation to employment but also with reference to a wider social positioning of the migrant as a ‘minority Christian’. In doing so, the research contributes to our understanding of the role of religion in migrants’ integration or marginalisation and of how migration is reconfiguring the Italian and Spanish societies through the production of new understandings of Christianity: these churches challenge the Catholic majority religion as well as dominant views of migrant religion as Islam only. The MIGRANTCHRISTIANITY project brings together two hitherto separate strands of research: that on migrant labour and ethnicity on the one hand, and that on migration and religion, more specifically on migration-driven Evangelical churches, on the other.

Mots clés : migration, ethnicity, racism, work, gender, ethnic churches, religion, ecuadorians, ghanaians, italy, spain

Participants :
- European University Institute (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160477.2 €