Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet BOLD MINDS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

BOLD MINDS aspires to enhance the understanding of vulnerability factors underlying the emergence of borderline personality disorder (BPD), with an ultimate aim of increasing the potential for young individuals to receive early, evidence-based help when their mental health is at risk. BOLD MINDS will achieve this by investigating whether disruptions in two aspects of autobiographical memory (AM), narrative identity (NI) and involuntary AM (IAM), are associated with BPD features and problem behaviours in adolescents concurrently and over time. In doing so, BOLD MINDS will strengthen the understanding of mechanisms underlying the emergence of BPD in adolescence and lay a groundwork for developing evidence-based early interventions for BPD. While currently limited, the study of AM in this field is essential for two reasons. Firstly, because the aspects of AM under investigation, NI and IAM, are known to be involved in identity formation and emotion regulation which represent two key psychological processes that are disrupted in adults with BPD and are linked to problem behaviours such as self-harm and suicidality. Secondly, because promising research is emerging on the use of AM targets in the treatment of emotional disorder in adults, and provides a strong model for future treatment development with vulnerable adolescents. In addition, this timely research program aligns with calls from international organizations to prioritize early interventions to promote adolescent mental health. BOLD MINDS will adopt and adapt state-of-the-art ecological momentary assessment and analytical techniques and work at the crossroads of clinical and cognitive psychological perspectives, allowing for a multidimensional approach to understanding BPD vulnerability. Training-through-research and formalized training of the experienced researcher will prepare her for a permanent academic position and the founding of her own research lab specializing in AM and early interventions for BPD.

Mots clés : borderline personality disorder, autobiographical memory, narrative identity, involuntary memory, adolescence, vulnerability factors, ecological momentary assessment, life story assessment

Participants :
- Université d'Aarhus (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 210911.04 €
Projet O2ZOOM (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The oceans are losing oxygen due to climate change. Among the largest impacts of oxygen loss may be in altering the behavior of zooplankton, the small animals that play a central role in marine ecosystems: as prey, predators, and carbon-flux mediators. The expansion of low-oxygen zones in deep waters may decrease the depth to which zooplankton migrate on a daily and seasonal basis. This change in their migratory behavior would impact the foraging success of their predators as well as reduce the ability of zooplankton to export carbon out of surface waters. O2ZOOM examines how the migratory behavior of krill, a key zooplankton species, is modified by low oxygen in a fjord habitat, and the ramifications for the global carbon pump, through a combination of novel acoustic observations, incubation experiments, and computational models. In O2ZOOM, I will 1) Investigate behavioral changes in krill in response to low oxygen through laboratory incubation experiments 2) Determine the migratory response of krill to low oxygen in a Norwegian fjord using novel acoustic techniques 3) Quantify the effect of low oxygen-induced behavioral changes in krill on carbon export in an individual-based model. O2ZOOM will produce a nuanced picture of the behavioral responses of krill to low oxygen, which would help disentangle the still-unquantified consequences of low oxygen for ecologically important fjord ecosystems, deep-ocean habitats, and, more broadly, the global carbon pump. Furthermore, through O2ZOOM, I will further develop my technical expertise (e.g. in acoustic tracking, advanced modeling, biogeochemistry analysis), expand my scientific network, and increase the impact of my research, steering my career towards answering big-picture questions on the cutting-edge of interdisciplinary ecology.

Mots clés : ocean deoxygenation, krill, global carbon pump, marine ecosystem, deep ocean hypoxia, diel vertical migration, biogeochemical cycles, active acoustics, laboratory incubations, modeling

Participants :
- Université d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 267418.56 €
Projet FREITPWP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

FREITPWP examines the genesis, evolution, and demise of several neo-fascist networks and organizations that operated across European borders during the post-war period (late 1940s to 1970s). These include the European Social Movement (ESB), the European New Order (NEO), and the National Party of Europe (NPE). The study puts forth a novel theoretical framework for analyzing these networks: far-right Europeanism, which is defined as a commitment to the political, economic, and cultural consolidation of the European continent among far-right agents, organizations, and parties, who based their inter-European collaboration on exclusionary, illiberal, anti-democratic, and racist ideas of Europe. The explicit emphasis on the notion of Europe as an ideological rationale for far-right internationalism represents a significant departure from the existing scholarship on right-wing politics in Europe. The study's long-term perspective, which links the inter-war and post-war periods to the present day, provides groundbreaking insights into the continuity and discontinuity of Europe's role in the international cooperation of the far right throughout the "long" 20th century. The project draws upon archival research conducted in a range of European countries, incorporates interdisciplinary methodological innovations, and collaborates with multiple experts in the field.

Mots clés : far right neo fascism fascism europeanism european integration transnational history post war period

Participants :
- Université d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 251578.56 €
Projet Deep-Cat (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

This project aims to develop an understanding of how the chemical environment (i.e. solvent, additive and ligand) can be adapted to tune the reactivity of transition metal catalysts, based on molecular dynamics modelling methods enhanced by machine learning. Pd-catalysed cross-coupling reactions are widespread in research and industry. The efficiency of these processes depends on a detailed molecular understanding of the catalytic cycles, which are highly sensitive to chemical environmental factors. The identification of active species in reaction mixtures is crucial, as demonstrated in the case of Pd-catalysed oxidative addition (Liang et Al., Inorg. Chem. 2021; Rio et Al., ACS Catal. 2023). This project employs deep-neural network potentials to address the challenges of nuclearity and reactivity commonly encountered in homogeneous catalysis, with a particular focus on the interaction of the catalyst with its chemical environment. The initial phase will investigate the speciation of the Pd(OAc)2 pre-catalyst in solvents of varying polarity, with the objective of controlling its nuclearity. Subsequently, these species will be subjected to further analysis at a static DFT level in oxidation reactions. The second part of the project will examine how the ratio of palladium to phosphine affects the nuclearity of palladium catalysts and the selectivity of cross-coupling reactions (Scott et al., JACS 2020). The last stage of the project, in collaboration with an international experimental leader, will broaden the project to investigate the role played by the chemical environment in Ni-catalysed single-electron transfer reactions (Tilley et al., Organometallics 2021). This project will significantly enhance the expertise of the applicant in multi-scale molecular modelling and machine learning methods, establishing them as a key player in the application of advanced computational techniques to address the diversity of challenges encountered in homogeneous catalysis.


Participants :
- Université d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 251578.56 €
Projet FLEXSTORE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

The progressive size diminution of electronic modules are undergoing bottlenecks in dwindling charge storage devices i.e., batteries and supercapacitors, constraining their development into wearable energy storage and flexible pollution free technologies. The inherent extended cycle life, rapid charge/discharge, and high power density of supercapacitors rank them superior over other energy storage systems. In modern market of zero-pollution energy devices, recently flexible and lightweight formula are trending to meet the current requirement of wearable energy storage. In this context, cellulose nanofiber (CNFs) incorporated zeolitic imidazole framework (ZIF) as hybridization have the potential to meet this demand, as they are core of active electrode materials for flexible supercapacitors and texturally tailored to demonstrate flexible/foldable properties. Thus, the exploration of the ZIF on CNF as a multifunctional hybrid material will provide high surface area and dispersion stability, while demonstrating superior analytical performance. FLEXSTOR will elucidate: 1) uniform distribution of ZIF nanocrystals on interface of CNF as conductive electrode 2) the rational design of polymer solid-state gel electrolyte in form of flexible solid-state supercapacitor and 3) the enhanced charge storage performance withstanding the mechanical deformation. With these perspectives, FLEXSTOR will introduce flexible and lightweight active compounds for wearable energy storage devices.

Mots clés : supercapacitors, flexible solid state supercapacitors, triboelectric nanogenerators, organic inorganic hybrids, conductive electrodes, wearable energy storage devices

Participants :
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
- Université de Sejong (Corée du Sud) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet NoMCod (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Title: The Immunological Puzzle of Atlantic Cod: Thriving Without MHC II  Francisellosis is a bacterial infection caused by Francisella noatunensis subsp noatunensis (F.n.n) in teleosts such as Atlantic cod (Gadus morhua). These vulnerable Atlantic cods are crucial for sustainability of the North Atlantic ecosystem and fisheries. The disease is generally manifested as granulomatous lesions in head, kidney, liver, gills, heart and spleen. At present, its treatment is a major challenges for commercial fisheries sectors with the current availability of only antibacterial drugs with limited efficacy and no licensed vaccine available for the fish, so far. Genome sequencing of Atlantic cod revealed lack of otherwise well conserved among other vertebrates, the major histocompatibility complex (MHC) class II immune pathway due to gene losses of MHC II, CD4 and invariant chain (Ii) and presence of an expanded MHC I and toll-like receptor (TLR) repertoire. Little is known for the compensatory mechanisms governing immune responses against infections in the cod, in the absence of MHC II. We aim to determine the functions of MHC I and TLRs and mechanisms of antigen presentation and immune responses to bacterial infection in the cod fish with 2 objectives 1) characterization of MHCs and TLRs using teleosts as model systems b) identify the mechanisms of bacterial infection involving MHCs and TLRs. The methodologies involve culturing of wild caught Atlantic cod derived primary macrophages and cell lines, transfection with fluorescently labelled MHCs and TLRs, microscopy (live-cell imaging, super-resolution microscopy), RUSH assays, mass spectrometry, pull down assays, transcriptomics to elucidate the role of different MHC I and TLRs in response to F.n.n infection. This will enable us to delineate expanded roles of MHC I and TLRs and provide a platform to develop effective antibacterial therapeutic strategies against F.n.n infection in Atlantic cods.

Mots clés : atlantic cod gadus morhua , mhc i, tlrs, antigen presentation, francisellosis, francisella tularensis

Participants :
- Université d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 267418.56 €
Projet PhySeaCS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Global warming and accelerating mean sea-level rise (SLR) arise the critical need for long-term (multi-decadal) shoreline projections to inform coastal adaptation plans. Currently, interactions among SLR and other processes driving shoreline change are poorly understood, and estimating the effects of SLR on long-term shoreline behaviour remains an open challenge. To fill this knowledge gap, this project will provide new physical insights on the combined effects of waves and SLR on sandy beaches, and develop an equilibrium-based approach for SLR-driven shoreline change. Shoreline data extracted from physical models, satellite imagery and topographic surveys at a variety of sites worldwide, allow building an unprecedented dataset of multi-decadal time series of shoreline positions. Such time series will be analysed to investigate the relations among shoreline change and its primary drivers (waves and SLR), and to validate the developed approach at a variety of selected sites worldwide. This study will characterize the role of waves in shoreline response to SLR, and provide a physics-based approach for more reliable assessment of long-term shoreline projections including the effects of SLR.

Mots clés : sea level rise, shoreline modelling, coastal erosion, climate change adaptation

Participants :
- Université polytechnique de Catalogne (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 257235.36 €
- Université d'Auckland (Nouvelle-Zélande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet NEoC (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : TERMINATED

Neurological conditions conquer the world; they are the leading cause of disability and second leading cause of death worldwide. Although there is growing evidence for the immense impact of disturbances in neurometabolism for overall brain function, only little is known about the underlying mechanisms (knowledge gap). Especially human insights are sparse due to a paucity of physiologically relevant model systems (research gap). To address these challenges, within the scope of the NeuroEnergetics-on-Chip (NEoC) project, I am proposing the development of a novel, human iPSC-based organ-on-chip model of the neurovascular unit (NVU) that integrates all neurometabolically active NVU cell types and specifically enables the inspection of neurometabolic coupling mechanisms. To categorically cast light onto the mechanisms behind impaired metabolism of glucose, the brain’s principal energy supplier, I will build an NVU-on-Chip disease model of glucose transporter 1 deficiency syndrome (GLUT1-DS). Since GLUT1-DS is monogenic, it presents an excellent paradigm to study cellular and molecular consequences of disturbed neuroenergetics, even beyond the disease itself. For implementation of the NEoC project, I will i) generate all neurometabolically relevant NVU cell types (endothelial cells, perivascular cells, astrocytes, microglia and neurons) from human iPSC lines derived from GLUT1-DS patients, ii) develop a novel NVU microfluidic platform addressing the shortcomings of existing NVU-on-Chip systems, and iii) build GLUT1-DS-NVU-on-Chip models to specifically study perturbations in energy metabolism, blood-brain barrier integrity and neuroinflammation as a consequence of GLUT1-DS in vitro. The NEoC project will provide novel knowledge on the underlying mechanisms and pathophysiology of GLUT1-DS, and thereby not only benefit those afflicted by the orphan disease but impact our understanding of a variety of other CNS and metabolically linked disorders.

Mots clés : organ on chip, microfluidics, neurovascular unit, neuroenergetics, ipscs, glut1 deficiency

Participants :
- Institut Karolinska (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet VITNK (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Natural killer (NK) cells are cytotoxic innate immune cells that defend against viral infections and cancer. As cancer is one of the leading causes of death worldwide, more effective treatment options are urgently needed. Harnessing NK cell cytotoxicity for cancer treatment shows promise, but there is still room for improvement, particularly against solid tumours, which are difficult to treat due to challenges such as limited tumour infiltration. Therefore, identifying targetable factors that enhance not only NK cell development, function, expansion and persistence, but also homing and migration are crucial to optimize cancer immunotherapies. Vitamin metabolites retinoic acid (RA) and calcitriol (CA) activate nuclear receptors (RAR, RXR, VDR) and regulate differentiation, function and homing properties of T cells and ILCs. In the VITNK project, I will systematically investigate how RA and CA as well as their nuclear receptors impact human NK cell development, differentiation, function, expansion, survival, and migration. To achieve this, haematopoietic stem cell-based NK cell differentiation cultures and short-term peripheral blood mature NK cell cultures will be used. In-depth analysis of the changes induced by vitamin metabolite supplementation and CRISPR-mediated nuclear receptor knockout using advanced cell-based assays in combination with cutting-edge single cell RNA, ATAC- and ChIP-sequencing will give a comprehensive insight into the molecular mechanisms that are governed by vitamin A and D in human NK cells. VITNK will thus establish how vitamin A and D modulate NK cell homing and migration, which is essential for efficient tumour infiltration. The purpose of VITNK is to take initial preclinical steps towards therapeutic targeting by thoroughly evaluating the potential of vitamin A and/or D to upgrade NK cell-based immunotherapy for solid tumours, paving a way for my future research career.

Mots clés : nk cells, tissue residency, lymphocyte homing

Participants :
- Institut Karolinska (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €
Projet BiorthoCat-Immuno (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

In this fellowship I will leverage the recent advances in biorthogonal chemistry to develop an implantable catalytic hydrogel for chemoimmunotherapy through transition metal-mediated biorthogonal drug uncaging. The past decade saw incredible advances in the field of cancer immunotherapies, with immune checkpoint blockade therapies and chimeric antigen receptor-T cell therapies demonstrating clinical efficacy. However, issues still exist, as life-threatening side effects and limited patient response. Therefore, there is a huge need for innovative solutions to improve immunotherapies outcome. This project seeks to apply the materials and reaction engineering competence of the applicant, together with the biomaterials expertise of the Stevens lab (Karolinska Institute) to design a nanocatalyst-doped hydrogel with tailored geometry, as the first biorthogonal catalytic system for cancer immunotherapy. The biomaterial developed in this fellowship will address cancer immunotherapy through a completely unexplored approach: catalytic uncaging of non-toxic prodrugs to their active form through metal-catalyzed depropargylation reactions, completely orthogonal to biological processes. The implant will enable uncaging of two toxic drugs: a chemotherapeutic – doxorubicin – inducing immunogenic cell death, and an immunostimulant drug – R848, a TLR7/8 agonist. The combination of drugs activated by the implant will enable localized cancer cells death with release of cancer-specific antigens, antigens then uptaken by antigen presenting cells, eventually eliciting antitumor immunity, towards a personalized cancer vaccine. The design of the scaffold will be guided by principles of biomaterials design and catalytic reaction engineering. Working in the Stevens lab I will access state-of-the-art equipment for materials synthesis and characterization, and cutting edge facilities to study the cell-material interactions in vitro and characterize the efficacy of the envisioned treatment.

Mots clés : biorthogonal chemistry, reaction engineering, immunotherapy, immunoengineering

Participants :
- Institut Karolinska (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 206887.68 €