Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MIRIC (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : TERMINATED

With more than 3.7 million new cases and 1.9 million deaths each year, cancer represents the second most important cause of death and morbidity in Europe with the estimated direct health cost increasing from €79 to €86 billion during 2005-2014. The emerging field of immune-checkpoint therapy (ICT) has demonstrated unprecedented responses in patients with several types of metastatic tumors that were previously resistant to available treatment options. However only ~13% of patients respond to the immunotherapy. I believe the primary reason for this is that most therapies are T cell directed and to achieve durable responses one must also engage the innate arm of the immune system. Myeloid cells constitute a major proportion of tumor infiltrating cells in human cancers and are essential for the induction of antigen specific T cell responses-cells which mediate anti-tumor immunity. Tim-3 is a check-point molecule that is not only expressed on T cells but also constitutively expressed on Dendritic cells, namely DC1, which are particularly adept at initiating protective anti-tumour immunity. A number of studies have highlighted the crucial role of DCs including analyses of The Cancer Genome Atlas showing that patient survival for many cancers correlates positively with the gene expression signature for DCs. Given the current activity in developing Tim-3 blocking agents for clinical translation, it is imperative that we have a full understanding of how modulation of Tim-3 affects the innate arm of the immune system. The aim of this proposal is to determine the cell-intrinsic and non cell-intrinsic effects of Tim-3 modulation in cancer. Furthermore we will analyze the cellular and transcriptional changes associated with tumour infiltrating DC after ICT with anti-Tim3. This proposal is highly interdisciplinary implementing single-cell 'omics' strategies and systems immunology approaches to further unravel the players and rules governing immune responses during malignancy.

Mots clés : cancer, immunotherapy, dendritic cells, t cells, single cell rna sequencing

Participants :
- University of Basel (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203149.44 €
Projet CrowdLawLab (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

With rates of trust in government at all-time lows, the legitimacy of traditional representative models of lawmaking, typically dominated by political party agendas and conducted by professional staff and politicians working behind closed doors, is called into question. But technology offers the promise of opening how parliaments and local legislatures work, creating new challenges and dangers for individual rights and democracy, but also generating unprecedented opportunities for improving the legitimacy and, more generally, the quality of law and decision-making in our political systems. CrowdLaw refers to the use of technology to engage the public in all stages of the lawmaking process, from problem identification to solution identification, proposal drafting, ratification, implementation and assessment. This research project deals with CrowdLaw in order to understand (theoretically and empirically) its impact on legislative institutions, the public and political culture. By exploiting technology to engage a broader and more diverse constituency in the lawmaking process, CrowdLaw has the potential to enhance the quality of lawmaking practices and to transform fundamentally the source of authority undergirding the legislative process. In this sense, three broad hypotheses will guide my work to measure the impact of digital democracy on individual participation, information quality and legislative outcomes. To do so, I am planning to: 1) Develop a taxonomy to organize and analyse CrowdLaw practices; 2) Conduct mixed-methods research to evaluate different CrowdLaw modalities and their legal frameworks and 3) Transform two local legislatures (Barcelona and Madrid) into CrowdLaw living labs to be able to conduct experiments that allow me to test how CrowdLaw initiatives impact the legitimacy and quality of lawmaking. The final goal of this research is to support legislatures, especially city councils, in designing more participatory lawmaking practices.

Mots clés : citizen empowerment, citizen engagement, citizen participation, crowdlaw, crowdsourcing, deliberative democracy, direct democracy, technology, lawmaking, decision making

Participants :
- Pompeu Fabra University (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172932.48 €
Projet COFUNDfellowsDTU (Horizon 2020, appel à projets 2015)
Action : Cofund Postdoctoral programme
Statut du projet : CLOSED

With the H.C. Ørsted Fellows Programme – co-funded by Marie Skłodowska Curie Actions (COFUNDfellowsDTU) DTU will attract highly talented young researchers through incoming mobility from around the world. The Programme takes place at the Technical University of Denmark (DTU) which is a top ranked university with focus on all Engineering Sciences as well as Life Science and Biotechnology. The Programme will provide uninterrupted continuity of the existing and highly successful co-funded Programme and introduce new improvements by offering both junior and senior fellowships, increase the number of fellowship years to 126, introduce effective career development and increase focus on industrial secondment and exploitation of innovative research results. Fellows will have the opportunity to shape their careers within the world-leading innovative environment at DTU, by engaging in curiosity-driven, bottom-up research according to their own choice within all available branches of engineering science. The Programme will introduce the opportunity of a 3 months secondment in industry, and implement the triple I – international, interdisciplinary and intersectoral exposure. This will prime fellows for careers in both academia and industry, and put innovation at the centre of the Programme. Grants will be awarded in open, international competition. The selection of successful proposals will be carried out in a process comprising the following three steps: 1) International peer review of each application by three reviewers, 2) Rebuttal to peer review from applicants and 3) Final decision on the award of fellowships by the DTU Selection Committee. DTU will ensure equal opportunity and introduce anonymisation of applicants' names and gender during the review process. The Programme is open to all interested candidates regardless of sex, age, ethnicity, religion and sexuality.

Mots clés : engineering, life sciences, biotechnology, technical science, postdoc programme, fellowship programme, management, mobility, triple i dimension, denmark, h c oersted

Participants :
- Technical University of Denmark (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 4460400.0 €
Projet EyeTREAT (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

With the ageing population, visual threatening illnesses are increasing. For instance, age-related macular degeneration (AMD) is expected to affect almost 25 million Europeans by 2040. The AMD treatment consists in regular injections of the anti-VEGF therapeutic drug (Lucentis, Avastin, Eylea) into the eye ball, vitreous, for the rest of the patient life. However, the dosing intervals varies widely among the patients and there is no a clear consensus or quantitative method for evaluating the injection frequency. For that, computational tools linking the drug dose regimen and the drug effect in the retina are needed. However, such pharmacokinetic-pharmacodynamic models are still missing. Combining population pharmacokinetic and optical coherence tomography (OCT) imaging technique is a new, novel and promising approach. The drug effect can be evaluated non-invasively, measuring the central macular thickness in the retina scan. The models generated will allow appropriate individualized dosing regimen to the patients in clinics that will be anticipated from individual retina scan determinations with OCT. The optimization and personalization of dosing regimen will ensure an efficient long-lasting treatment, improving patient quality of life while reducing the burden to the health care system. Moreover, the models will increase our understanding in the treatments, constitute a pioneer tool in effect assessment in ocular therapeutic field and a first step towards more advanced ophthalmic models. The candidate has strong expertise in intravitreal pharmacokinetic and this project will advance her into clinical pharmacodynamic modelling at the renowned Centre for Applied Pharmacokinetic Research, University of Manchester. The inter-disciplinary and inter-sectoral character of the project will definitely benefit her career development as a researcher.

Mots clés : ocular pharmacokinetics, pharmacodynamics, clinics, optical coherence tomography, nonlinear mixed effects model, physiologically based pharmacokinetic model, central macular thickness, pharmacometrics

Participants :
- University of Manchester (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 122159.25 €
Projet Chinese Labour (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

With the financial crisis stepping up the pressure on labour regimes around Europe, and with the European national economies increasingly subject to the vagaries of an uncertain Chinese growth, questions traditionally of interest only to Chinese labour specialists and rights advocates are taking a whole new dimension. Chinese labour issues have ceased to be local matters and have assumed a particular urgency, entering much of the political rhetoric of the European countries. Such diffused presence of Chinese labour in the European imaginary raises many questions and requires a thorough investigation. In particular, in the past few years, much has been written about a “rights awakening” allegedly undergoing among internal migrant workers in China. But how do Chinese workers perceive their rights? What role do Chinese state and non-state actors play in shaping this perception? And, more important, how will these shifting dynamics of Chinese labour activism affect the future of China as a “world factory”? Research that answers these questions is still scarce. The purpose of this study is threefold: a) analyse the expectations of Chinese migrant workers toward work hours and salaries, on the background of the minimum standards mandated by the current labour legislation; b) deconstruct the role played by different actors in shaping these expectation, with a particular attention to the role of the central and local state, the union, civil society organizations and foreign enterprises; c) address the implications of the rising expectations of the Chinese workers for EU investments in China and for the future of the country as a “world factory”. This research will not only give a meaningful contribution to the academic debate, but will also provide European policy-makers, companies, trade unions and labour NGOs with much needed knowledge on how to address Chinese labour issues in this new phase of the globalization process.

Mots clés : china, globalization, labour, migrant workers, cambodia, activism, race to the bottom, ngos, trade unions, hegemony

Participants :
- Australian National University (Australie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 250518.6 €
Projet HyComp (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : TERMINATED

With the growing environmental concerns, lightweight structural designs are becoming increasingly important as they help meet the global emission regulations. Fibre-reinforced composites are the current state-of-the-art for lightweight structures and their use is rising exponentially in a wide range of applications from aerospace to sporting goods. They exhibit a range of useful material properties—notably specific stiffness and strength—whilst affording rich design flexibility. Fibre-hybridisation further increases the design space for tailoring and is a promising strategy for improving toughness and damage tolerance, which otherwise are low for traditional non-hybrid composites. By combining two or more fibre types, a better balance in mechanical properties is obtained which often leads to synergetic effects or to properties that neither of the constituents possesses. Due to these advantages, fibre-hybrid composites rapidly gaining market share in structural applications. Even though fibre-hybrid composites are attractive, they also pose more challenges in terms of their strength predictions. Under tension, composites suffer a range of failures typically associated with fibre breakage, matrix cracks or interfacial issues; these mechanisms interact in a complicated way at a variety of physical length-scales. The added complexity of having more than one fibre type further increases the complexity in the modelling of mechanistic processes. Therefore, there is a need for developing a modelling framework to predict the strength of fibre-hybrid composites, considering the failure mechanisms on multiple length-scales. Using the model, one can understand better the influencing parameters on the failure of fibre-hybrids without the need for extensive experimental campaigns. Ultimately, this development may lead to novel materials that enable new applications, not possible at this moment.

Mots clés : composite materials, finite element analysis, structural mechanics

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 178320.0 €
Projet SUSTAINABLE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

With the increasing concerns on the environmental issues and with the depletion of fossil-based resources, sustainable chemistries for the development of resins from bio-based molecules and for the reprocessing and recycling of plastics are strongly demanded. In this context, SUSTAINABLE is aimed at developing inedited photopolymerizable bio-based resins employable for the 3D-printing of green, self-healing and recyclable thermosets. While photopolymerization 3D-printing has been widely employed for the obtainment and chemical optimization of thermosets from fossil-based resources, few scientific works have dealt with the design of bio-based photopolymerizable resins for 3D-printing. To complete the curing of the thermosets, the project will investigate an innovative cold atmospheric pressure plasma (CAP) assisted approach, as a more flexible alternative to the conventional UV exposure. SUSTAINABLE, proposing possible strategies to reduce the environmental issues linked to the single-use plastic devices disposal, contributes to the achievement of Goal 12: “Ensure sustainable consumption and production pattern” of United Nations’ Sustainable Development Goals. The programme will be developed by a researcher with a PhD in Engineering and skills on design, realization and optimization of CAP sources for materials processing; the fellowship will be performed at KTH in Stockholm, under the supervision of Prof. M. Hakkarainen, who has acknowledged expertise in the synthesis, processing and end-of-life management of bio-based, degradable and/or recyclable plastics. SUSTAINABLE requires expertise from organic chemistry, materials manufacturing and processing, materials characterization and will thereby diversify the competences of both the researcher and the Host Group. This action prepares the fellow for the achievement of a more permanent position by endowing her with crucial opportunities to gain new scientific competences and improving her transversal skills.

Mots clés : self healing and recyclable thermosets, 3d printing, plasma technology, bio based resins, functionalized resins

Participants :
- KTH Royal Institute of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203852.16 €
Projet PriMa (Horizon 2020, appel à projets 2019)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : SIGNED

With the rapid increase in technological means for personal information capture and surveillance and the use of Artificial Intelligence, there is growing challenge to establishing and maintaining individual privacy. One important factor contributing to the erosion of privacy is the growth in biometric person recognition technologies. Another is the increasing possibility for extensive data mining, allowing for the aggregation, linkage and inference of personal information of individuals active on the internet. With the ubiquity of sensors (in mobile devices, CCTV cameras, etc.) and processing power, there is a real possibility that privacy may become an unattainable goal unless technological and societal steps are taken to allow the citizens to regain control of their personal information and activities. The ITN PriMa aims at training the next generation of researchers and technologists who have an all-round understanding of the multidisciplinary nature of the issues involved and who can contribute to the development of solutions that address this important societal challenge. PriMa will bring together Europe-wide complementary academic and industrial expertise to investigate these issues and provide a structure and environment to effectively facilitate training. The proposed ITN will cover the technological issues regarding privacy protection for biometric technologies as well as the related ethical, legal and psychological issues. The ITN will comprise academic and industrial partners, as well as an external advisory board. The academic partners from different European states will each run inter-related PhD programs requiring their ITN Early-Stage Researchers (ESR) to visit and work on their project at other partner universities, as well as at industrial partners, to develop a wider vision of the subject and their potential for contribution and collaboration.

Mots clés : privacy protection, privacy leakage, biometrics

Participants :
- KU Leuven (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 512640.0 €
- Norwegian Computing Center (Norvège) — Partner, beneficiary, Recherche, subvention : 584684.64 €
- University of Twente (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 531239.76 €
- University of Kent (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- University of Würzburg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 505576.8 €
- Autonomous University of Madrid (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 501809.76 €
- Norwegian University of Science and Technology (Norvège) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 584684.64 €
Projet SOLOC (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

With the rise of urbanization, silence has become a rarity. Sound is all around us, and our hearing skills are essential in everyday life. Spatial hearing is one of these skills: We use sound localization to determine where something is happening in our surroundings, or to ‘zoom in’ on a friend’s voice and filter out the noise background in the bar. But how does the brain compute the location of real-life, complex sounds such as a voice? Knowledge of these neural computational mechanisms is crucial to develop remedies for when spatial hearing fails, such as in hearing loss (>34 million EU citizens). Hearing impaired (HI) listeners experience great difficulties with understanding speech in everyday, noisy environments despite the use of an assistive hearing device like a cochlear implant (CI). Their difficulties are partially caused by reduced spatial hearing, which hampers filtering out a specific sound such as a voice based on its position. The resulting communication problems impact personal wellbeing as well as the economy (e.g. higher unemployment rates). In SOLOC, I use an innovative, intersectional approach combining cutting-edge computational modelling (deep neural networks) with state-of-the-art neuroscience and clinical audiology to gain insight into the brain mechanisms underpinning sound localization. Using this knowledge, I explore signal processing strategies for CIs that boost spatial encoding in the brain to improve speech-in-noise understanding. Through this Global Fellowship, I connect the unique computational expertise of Prof. Mesgarani (Columbia University) and his experience with translating computational neuroscience into clinical applications, to the exceptional medical expertise on hearing loss and CIs of Prof. Kremer (Maastricht University). Hence, by implementing SOLOC I will diversify myself into a multidisciplinary, independent researcher operating at the interface of neuroscience, computational modelling, and clinical audiology.

Mots clés : sound localization, hearing loss, fmri, ecog

Participants :
- Columbia University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Radboud University Nijmegen (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 182419.2 €