Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SINFONIA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The wine industry is one of the agri-food sectors most highly influenced by climate variability and change at different timescales. In particular, the integration of reliable and timely sub-seasonal to seasonal (S2S) climate information in decision-making might help the wine sector to better manage climate-related risks. This explains the recent interest of the wine industry in these sources of climate information. However, one of the challenges that prevent the users from the uptake of climate information is the lack of coherence between the climate predictions from different sources (i.e., forecast systems at sub-seasonal and seasonal time scales). This project will develop a novel methodology to produce coherent S2S seamless climate information for the wine industry. This will involve 1) the understanding of the inconsistencies between the climate prediction sources at S2S timescales that prevent the users from a coherent flow of climate information and 2) the implementation of a methodology that merges sub-seasonal and seasonal predictions by using the knowledge from the physical processes relevant for the climate predictability at both timescales. The new scientific knowledge and methods will be co-developed in collaboration with representative stakeholders. They will work with the fellow to design the climate information that has actual value for the management of the vineyards, wineries, and the strategic planning for the wine market. The methods developed in this project could be further exploited to produce seamless S2S predictions for other socio-economic sectors (e.g., agriculture, health, and energy). This action will be developed at the Barcelona Supercomputing Center (Spain), a well-known institution in the implementation of successful climate services for different socio-economic sectors. Furthermore, a secondment period is projected at Météo-France (France), which is a producing centre of operational sub-seasonal and seasonal predictions.

Mots clés : sub seasonal prediction, seasonal prediction, climate services, co production, wine production, seamless climate information

Participants :
- Météo-France (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université polytechnique de Catalogne (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet UnderTheForest (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Despite summer wildfires and the expansion of urban and agricultural areas, Mediterranean mountains have experienced extensive afforestation during the last 70 years. This has largely been a consequence of the abandonment of these areas and the loss of their traditional management strategies. Afforestation processes not just imply an important heritage loss as cultural landscapes disappear under the forest without having been studied but they also boost wildfires, as traditional ways of managing the forests were not replaced by proactive forest monitoring. UnderTheForest will study the cultural landscape under threat of afforestation and already afforested in the area of Zagori (Greece), identifying and dating its human and natural elements and linking them to specific historical and socioeconomical processes. Despite being considered an area of exceptional natural heritage, Zagori’s cultural management has focused on its villages and their architectural elements, overlooking the landscape that sustained them. UnderTheForest will provide important data for Zagori’s ongoing bid for the UNESCO World Heritage Site as a Cultural Landscape. In order to do so, UnderTheForest will develop an innovative remote sensing workflow joining photogrammetric reconstruction for historical aerial imagery (1945 onwards), machine-learning probabilistic classification of multitemporal, multisource satellite imagery, and drone-based lidar survey (which will be able to locate structures under forest cover). Together with more traditional archival research, pedestrian survey, trench excavation and radiocarbon dating, the project will identify and contextualise the cultural assets that made this landscape unique and provide new tools that can be applied to other areas currently under afforestation processes.

Mots clés : mountain environments, landscape archaeology, cultural landscapes, gis, computational archaeology

Participants :
- Université polytechnique de Catalogne (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet VARSUBIN (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Variability is one of the few consistent characteristics of biological systems occurring at different levels of organization, from biomes to individuals. Moreover, at individual level, a vast amount of trait variation occurs within single individuals of modular organisms such as plants. Subindividual trait variation is mainly due to organ level phenotypic plasticity, and it has an epigenetic basis. In plants, subindividual trait variation occurs between multiple repeated organs, such as different leaves, fruits, flowers, and which are reruns of the same genotype under different micro-environmental conditions. Subindividual variation can be larger than among individual or among population variation, being a major source of phenotypic variation in nature. However, because subindividual variation is generated within individual genotypes, it has been inaccurately assumed to be invisible to ecological or evolutionary processes. Therefore, its adaptative role to global changes as well as the associated potential impact on ecosystem functioning is currently unknown. Given the importance of biodiversity for ecosystem functioning and mitigation of anthropogenic change, understanding the evolutionary and ecological consequences of a vast biodiversity asset such as subindividual trait variation is a major scientific and societal challenge. The main goal of this Marie Sklodowska-Curie fellowship is to evaluate the role of subindividual variation for plant adaptation to climatic change and to quantify the knock-on effects on ecosystem functions. To achieve this goal MS proposes a multi-generational artificial-selection and ecosystem experiment at a state-of-the-art experimental research facility (the Ecotron of Montpellier) equipped for automatic high-frequency measurements of multiple ecosystem processes (e.g. CO2 net ecosystem exchange, water use efficiency) and stable isotope 13CO2 labeling (for estimation of soil carbon storage).

Mots clés : ecosystem fluxes, atmospheric carbon capture, soil carbon storage

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet MUCH (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

MUCH delves into the crucial and still vastly understudied interplay between mathematics and philosophy in the 14th c., shedding light on pre-modern questions that resonate with ongoing concerns on mathematical knowledge, abstraction, and reality. What is the link between calculation and the conception of a quantified item? How do we think of a quantifiable unknown in equations? The case of 14th-c. Italy is key to grasp the emergence of such problems, their development and cascade-effect on European mathematics of the following centuries. MUCH unravels the feedback loop between philosophical notions and processes involved in mathematical practices, prominently algebra: quantum, inquantum, and variable in equations. Rooted in pre-modern notions of extension, quantum represents an existing quantified substance, while the variable (i.e., unknown value) stands as a neither continuous nor discrete thing that can be quantified. Inquantum is the specific epistemic process connecting quantum and the variable: a layered abstraction that allows mathematical properties to be distilled from non-mathematical ones. For the first time, MUCH implements a careful study, connecting pre-modern texts and actors from different institutional and professional settings (universities, religious and merchant schools). By intertwining historical contexts, MUCH disentangles how quantum’s and inquantum’s philosophical underpinnings paved the way for Ch’s mathematical application, contributing to a more comprehensive understanding of the pre-modern scientific thought. MUCH’s leading-edge hypothesis has the broader academic goal of bridging the research fields of history of mathematics and philosophy, deepening our comprehension of historical mathematical development but also emphasizing the inseparable relationship between philosophical inquiry and scientific progress.

Mots clés : history of medieval philosophy history of medieval mathematics medieval italy epistemology of quantification

Participants :
- Université Radboud de Nimègue (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet MS4PFAS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Per- and Polyfluoroalkyl substances (PFAS) are undoubtedly a worldwide threat due to their high persistence and widespread distribution in the environment, bioaccumulation capacity, and toxic effect on human health through chronic exposure. Despite a lot of research has been conducted to find solutions for the "PFAS problem", critical gaps such as the lack of transparency of manufacturers, the analytical issues to determine PFAS, and the difficulties to find the best way to regulate them and minimize the environmental and human exposure remain the major challenges. Thus, it is important to develop an analytical platform not only to increase the reliability of PFAS determination but also to provide analytical tools to policymakers for a better application of in-force and future regulations. MS4PFAS aims to propose high-throughput cutting-edge methodologies based on mass spectrometry (MS) to sort out the complexity of the analysis of the vast families of PFAS. The use of novel and/or dual atmospheric pressure ionization techniques for non-targeted liquid chromatography-high-resolution mass spectrometry approaches will increase the range of ionizable substances and will lead to unprecedented advantages to achieve a wide-scope determination of ionic and neutral PFAS in biological and environmental matrices. The most promising analytical platform will be chosen to propose highly confident identification strategies that will be integrated into a powerful non-targeted workflow to address the determination of known and emerging PFAS. The workflow will be validated and used to extend the knowledge in relevant societal applications such as the monitoring of PFAS in drinking water, updating the development of more efficient water treatment technologies, and in human biofluids (breast milk, plasma, urine), upgrading running epidemiological studies on the links of chronic exposure to PFAS and observed health impairments.

Mots clés : per and polyfluorinated alkyl substances pfas , high resolution mass spectrometry, gas phase atmospheric pressure ionization sources, non targeted analysis, water contamination, human biofluids

Participants :
- Université de Stockholm (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université du Pays basque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet GYR4CO2 (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Addressing the urgent global challenge of reducing atmospheric CO2 concentrations requires the development of efficient technologies for carbon capture and sequestration (CCS). The GYR4CO2 project addresses the urgent need to reduce atmospheric CO2 levels by developing advanced carbon capture and sequestration (CCS) technologies. A central focus is on enhancing CCS performance through innovative solid sorbents, by creating novel polymer-graphene composites with highly ordered porous structures. The project aims to synthesize these composites using co-assembly techniques involving graphene oxide platelets and block copolymers from aqueous dispersions. The target is to form negatively curved sp²-hybridized carbon structures, known as Schwarzites, which mimic the topologies of triply periodic minimal surfaces, particularly gyroid morphologies. By meticulously designing these multiphase composites, the project anticipates that the unique geometries will foster stronger interactions with polymer chains, leading to the development of hierarchically porous nanostructures. While theoretical models of graphene gyroid structures exist, GYR4CO2 seeks to realize these nanomaterials experimentally for the first time. The project will also involve synthesizing novel thiol-ene block copolymers, which will spontaneously assemble into gyroid morphologies and be integrated with graphene nanomaterials. The efficacy of these gyroid structures— purely polymeric, graphene, or composite—will be assessed for CCS performance in both individual gas models and real mixed gas systems. The goal is to achieve a CO2 capture capacity exceeding 4 mmol/g, along with high selectivity against nitrogen, oxygen, and humidity. Success in these areas will pave the way for innovative CCS technologies. Additionally, the project aims to enhance Y. Tamsilian's research capabilities, employability, and professional network through interdisciplinary experiences and improved communication skills.

Mots clés : co2 capture, graphene, copolymer, gyroid nanostructures, thiol ene step growth polymerization, chemical building blocks, triply periodic minimal surfaces

Participants :
- Basque center for macromolecular design and engineering polymat fundazioa (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Graphenea (Spain) (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université du Pays basque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €
Projet TLSaRNA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : TERMINATED

Tertiary lymphoid structures (TLS) are ectopically generated lymphoid structures with some level of cellular organisation similar to the secondary lymphoid organs, characterised by having a B-cell zone adjacent to a T-cell zone. The presence of tumor immune infiltrates, especially in the form of TLS, has been linked to a better cancer prognosis in different types of tumor and improved response to immune checkpoint inhibitors (ICB). However, interestingly, not all the patients develop TLS and the cellular composition and organisation within the structures can vary. Specifically, the role of B cells in the tumor microenvironment is controversial, while some studies have reported a pro-tumoral effect, possibly through differentiation of regulatory B cells, metadata shows a strong association between the presence of a transcriptional B cell profile on the tumors and the improved patient outcome. Moreover, the presence of B cells in the tissue microenvironment is also positively associated with an improved response to ICB. However, even though these strong statistical associations and the relevance of TLS in the cancer prognosis, still little is known about the mechanisms underlying their function and the specific role of B cells in the anti-tumoral response elicited. In this proposal, we will study novel therapies for artificial TLS induction by using intratumoral injection of mRNAs encoding for specific cytokines. We will deeply characterise the synergy between immunotherapy treatments and TLS in the tumor development by using the state-of-the art spatial transcriptomics and immunophenotyping. Finally, we will decipher the function of tumor-specific B cells on the tumor microenvironment and the relevance of tumor-specific secreted antibodies in the overall anti-tumoral response. Ultimately, the knowledge generated with this proposal will provide relevant information to guide future immunotherapy treatments.

Mots clés : tertiary lymphoid structures, immunotherapy, b cells

Participants :
- Université de Navarre (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet MERLIN (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Water contaminants of emerging concern (CEC) are pressing issues due to their high persistence and deep impact on ecosystems. Amongst them, antibiotics contribute indelibly to the proliferation of 2nd generation CECs, such as antibiotic-resistant bacteria and -resistance genes. MERLIN project pursues developing an integral and green solution for the abatement of CECs water pollution by applying forefront photo-thermo-catalytic membranes. Thus, photocatalysis arises as one of the greener and more promising technologies for CECs mineralization. However, its success is conditional on the use of semiconductors (SCs) with ad-hoc properties to work under solar irradiation. MERLIN will finely tune the band-edge potentials of novel photoactive SCs, in order to expand their solar light harvesting capacity and efficiency. In addition, the cooperative effects of dual photo- and -thermal catalysts will be explored by engineering local thermal energy “hot-spots” into SCs photocatalyst. For instance, the thermal-assisted photodegradation of CECs is foreseen to overcome the performance of classic photocatalytic systems. So, MERLIN aims by engineering the band gap of nanostructured SnO2 and CuO SCs to confer them a plasmonic response, making them autarchic photo- thermo- catalyst materials (PPTM) able to drive an accelerated CECs mineralization. In addition, MERLIN proposes developing forefront photo-thermo-catalytic nanocomposite membranes through the immobilization of PPTM into 3D-polymeric micro-structured membranes via 3D printing techniques. These composites pursue to immobilize CECs into the polymeric scaffold while PPTM nanotechnology faces their degradation (and of their sub-products) until their complete mineralization. Finally, MERLIN will run under the circular economy concept, where the green membranes will be developed for their recovery and reusability, considering the full assessment of their ecotoxicity.

Mots clés : photothermal, polymeric membranes, semiconductors, morphology, photocatalysis, nanomaterials

Participants :
- Université du Minho (Portugal) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Basque Center for Materials, Applications and Nanostructures (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
- TE Laboratories (Ireland) (Irlande) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet NanoCHROMS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cells respond to physical stimuli from their environment, drastically changing their chromatin organization. Direct nuclear mechanotransduction affects cell behavior, but this mechanism is still not fully understood. This unsolved link is due to the difficulty of finding tools to generate precise mechanical signals and observe changes in chromatin at the nanoscale level. NanoCHROMS aims to understand the effect of nuclear mechanotransduction on nuclear architecture. We aim to characterize the mechanism driving localized chromatin structure changes in response to direct physical stimuli, and how these changes relate to cellular state. NanoCHROMS will exploit two novel and powerful technologies, Nanofabrication and Single Molecule Localization Microscopy (SMLM). For that, we will use nanopillars as nanomechanical actuators. By culturing somatic, stem and cancer cells in a fabricated nanopillar surface, purposely designed to be SMLM-compatible, we can exert a precise, controlled, and replicable force in the nucleus. Using SMLM, we can unveil higher order chromatin folding with nanometric precision, obtaining positional information of DNA and nucleosome packaging, directly related to cell function. By using SMLM in cells growing on nanopillared surfaces, we can establish the changes of chromatin in direct relation to the physical point of application of the stimulus at the nanoscale. Finally, using sequence-specific imaging approaches (Oligopaints) we will study the nuclear positioning and compaction of genes whose expression is drastically affected by mechanotransduction. NanoCHROMS will contribute to understanding the mechanisms driving expression changes, maintenance of stemness and oncogenesis by mechanostimulus, being a steppingstone in projects working in the interface between cell biology and nanomaterials science. Finally, NanoCHROMS will develop a systematic and quantitative method to evaluate the effect of different nanostructures on nuclear architecture.

Mots clés : chromatin structure, mechanobiology, super resolution microscopy, nanopillars, single molecule localization microscopy, cohesin, ewing s sarcoma

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet KENA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Significant efforts are underway in Europe to re-shore the synthesis of active chemical ingredients (API’s) to ensure the safety and availability of medicine for its citizens. This goes hand in hand with innovations and process intensification. For example, doing multiple chemical reaction steps in one go, and/or by using continuous flow reactors that are more energy and solvent efficient, with a smaller footprint, scalable (by numbering-up), and cheaper to build and maintain. A key issue, however, of doing multiple reactions at once is that different reactants and products can react, thus forming a chemical reaction network (CRN). While CRN’s are ubiquitous in biological systems, they are mostly avoided in industry due to their complex behavior and effort needed to understand and quantify them. In this project, I propose a new method to analyse experimental kinetic data in order to directly determine the structure of the CRN. To this end, I will develop Kinetic Exponent Network Analysis (KENA) to study CRN’s that are of high interest for academia as well as industry. The change in concentration at early times can be described with power laws, from which the network connectivity of species population and thus the CRN structure can be deduced. KENA could then optimize the chemical conversion and selectivity of the desired products in CRN’s, contributing to efficient API re-implementation in Europe.

Mots clés : chemical reaction networks kinetics optimisation

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €