Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet RNAPII biogenesis (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cellular diversity in eukaryotic organisms is obtained through differential regulation of transcription, which is therefore a heavily studied step in gene expression. Protein-coding genes are transcribed by RNA polymerase II (RNAPII), an enzyme consisting of twelve subunits. Recently, work from my host lab, the Svejstrup lab, has suggested that depleting the number of fully assembled RNAPII molecules in the cell, through degradation of its main catalytic subunit RPB1, is crucial for achieving transcription recovery after DNA damage. This finding underscores the importance of understanding how RNAPII levels are regulated. Therefore, in this proposal I aim to gain insight into the mechanisms influencing RNAPII abundance, by studying RPB1 mRNA and protein levels, RNAPII assembly, and RNAPII transport in human cells. Specifically, I will leverage my background in RNA biology and bioinformatics analysis to identify RNA-binding proteins interacting with the 3’UTR of RPB1, and study their role in regulating RPB1 mRNA turnover and translation efficiency. Moreover, using state-of-the-art selective ribosomal profiling techniques, I will determine whether RNAPII is assembled co-translationally, as was recently proposed to be the mechanism of assembly for most multi-subunit complexes in eukaryotes. Finally, I will perform a CRISPR-Cas9 screen to identify novel factors that mediate RNAPII nuclear import. Together, this proposal will elucidate the biogenesis of RNAPII, which is crucial for a better understanding of transcription regulation. The proposed experiments will enhance my postdoctoral training by broadening my conceptual and technical skills and will provide data and tools to start my own laboratory in the future. Ultimately, these findings might also have therapeutic implications, as RNAPII is one of the targets being investigated for cancer treatments.

Mots clés : rna polymerase ii, transcription, gene expression, co translational assembly, mrna translation, 3 utr, protein biogenesis, nucleocytoplasmic transport, crispr cas9 screen, transcriptomics, interactome

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
Projet HybDDEF (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Extruded thermoplastic profiles are widely used in a large range of application fields, such as medical, electronic, etc. The crosssection geometry of these profiles is designed to fulfill the needs of a specific application, and the engineering process used to achieve this geometric conditions is known as extrusion, where a polymer melt is pushed through a die to convert it into the desired shape. Although this technique is widely used in the industry, the process of production of extruded profiles is far from being efficient, since the standard methods of manufacturing are based on experimental trial-and-error approaches, which are time consuming and waste materials. With the increase in computational power and the development of numerical methods, efforts have been made to improve these approaches. Although engineers have developed physics-based codes that assist in the design of extrusion dies and calibrators (where the polymer is cooled down to assure its mechanical resistance) during the last years, the existing codes present several limitations; i. e., the viscoelastic nature of the polymer and realistic heating systems are not considered, and the phenomena that occur in these tools are highly coupled, but the codes treat separately both the die and the calibrator. In this project, we will improve the existing codes by incorporating the novelties previously mentioned and will develop an integrated automatic open-source code that considers the simultaneous modelling of both the die and calibrator. Lastly, we will use a physics-augmented learning and hybrid modelling approach, where we will combine novel data driven and machine-learning techniques (based on experimental data) with our developed codes in order to derive a hybrid model, which will take into account the deviation between the measured physical reality and our physics-based simulations. This hybrid approach will assist in the optimal design of polymer extrusion tools (extrusion die and calibrator).

Mots clés : profile extrusion, polymer processing, computational rheology, machine learning, automatic design, hybrid data driven, physics augmented learning

Participants :
- Université du Minho (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191343.12 €
- Arts et Métiers Sciences et Technologies (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet MARELS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The MARELS project aims to study the connections between Saharan pastoral minorities and the conflictual situation in Mali and Niger through the unusual prism of growing higher-education student mobilities. Like other young Africans, Saharan students increasingly cross the borders in search of knowledge in another country for the purpose of gaining professional perspectives and acquiring global skills and languages, further weakening the number of highly trained Saharan professionals. Saharan nomadic populations have been characterized in the past by difficult access and high drop-out rates across all levels of education, largely due to conflicts, poor infrastructure and economic vulnerability compared to urban regions in the Sahara-Sahel. It is believed that student international mobilities have the capability of ushering in a new set of Saharan leaders who are competent to make the best use of human and material resources for the promotion of a peaceful, prosperous and integrated Sahara-Sahel in Africa. The challenge of this project is to write the unknown histories of Saharan graduates and to revise the common narrative of the Sahara as isolated and disconnected from the rest of the world, following the “mobility turn” in anthropology. Although much research has been produced on Saharan mobilities, scarce attention is given to student mobilities . The MARELS project aims to fill this gap and provide an answer to the following questions. What role do Saharan professionals trained in international universities play in their home societies, given the sometimes conflicting expectations from the local community, traditional élites, institutions, government, companies, foreign actors (e.g., NGOs, military forces) etc? How do Saharan graduate élites establish objectives and strategic actions oriented towards meeting these expectations when they are in a diaspora in the Global North?

Mots clés : anthropology oral history student mobilities african studies sahara sahel

Participants :
- Université de Johannesbourg (Afrique du Sud) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École des hautes études en sciences sociales (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet CAREFAL (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Adolescents in alternative care are at high risk of developmental outcomes. However, adolescence also offers avenues for positive changes and recovery from early adversities. To date, research has faced challenges in determining how adolescents’ psychosocial functioning changes during their time in care, and underlying mechanisms that contribute to resilience and wellbeing. Therefore, the question of “what works, for whom, and in what circumstances?” remains unanswered. The CAREFAL project draws on psychology, social anthropology, and public health to disentangle the developmental trajectories of adolescents in two alternative care settings (i.e., family foster care, residential care). This unique proposal aims to explore the differences across settings and how adolescents’ self-regulation interacts with the quality of their relationships with caregivers to promote positive outcomes. Additionally, CAREFAL aims at comparing the two cases of Spain and Portugal to optimize services and resources in each country. I will use a longitudinal, mixed-method, multi-informant, comparative approach to achieve the research objectives. The quantitative phase will involve a 6-month longitudinal study, incorporating data from caregivers, adolescents, and administrative records. This will be complemented by in-depth interviews with adolescents and caregivers. The research outputs will have: 1) scientific impact, as they will enhance our understanding of adolescent development across alternative care settings; 2) social impact, as they will equip families and professionals with evidence-based resources for improving adolescents’ self-regulation and caregiver-youth relationships; and 3) economic impact, as they will contribute to the specialization of alternative care and the efficient use of resources. By enhancing my expertise through conceptual, methodological, and communication training, I will be better equipped to showcase my abilities in both academic and non-academic markets.

Mots clés : adolescents foster care residential care resilience

Participants :
- Associacao iscte conhecimento e inovacao - centro de valorizacao e transferencia de tecnologias (Portugal) — Coordinator, beneficiary, Recherche, subvention : 191343.12 €
Projet CORESIST (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Gender and sexuality became highly politicized, especially after the emergence of the first anti-gender campaigns in Europe in the mid-2000s. Mobilisations took place in several countries against sexual and reproductive rights, LGBTQI rights, children’s rights, gender, laws and policies against hate speech and discrimination. While the expanding literature on anti-gender campaigns has allowed us to gain significant insights about the larger political project of those involved, we know less about resistance to anti-gender politics. Although resistance to anti-gender politics seems to involve a multiplicity of actors, internally heterogeneous, at times organised in coalitions, the sparse literature on the topic focuses mostly on single-issue movements or campaigns, adopting a rather public policy approach. When accounting for the multiple actors involved, studies are based on the implicit idea that some social groups are “natural allies”, as for example, women, LGBTQI or racialized people, leaving unaddressed the tensions and challenges permeating coalition-making, as well as the processes that create and maintain boundaries between actors. The present project - CORESIST attempts to fill in these gaps by analysing the ways in which the foregrounding of coalitions between actors contribute to strengthening and/or weakening of the resistance to anti-gender politics as well as the tensions and challenges that permeate coalition-making. Additionally, it will explore the ways in which different actors making resistance articulate the relationship between the various issues targeted by anti-gender politics. To do so, it adopts a comparative framework of the most dissimilar cases – France and Romania, grounded in political sociology, gender studies and decolonial theory.

Mots clés : social movements, political resistance, anti gender politics, coalitions, feminism, lgbtqi, race and ethnicity, decolonial theory, intersectionality, affects, gender and sexuality

Participants :
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
- Université de Linköping (Suède) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Copenhague (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet BioBar (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Waste management and final disposal cause severe environmental impacts. Even in modern landfills, installed engineered barriers worsen their hydraulic performance after 8 years of landfill operation, which can lead to leachate leakage and environmental pollution in the medium to long term. In addition, the use of clay as landfill barriers relies on a non-renewable resource and entails high economic and environmental costs when such a resource is not locally available. Therefore, it is necessary to develop barriers made of renewable and/or recycled sources, which not only promote leachate containment but also enhance its in-situ treatment and attenuation. This project will take advantage of the bacteria naturally occurring in leachate that grow and form biofilms by consuming the organic compounds. We will apply the biofilm-forming bacteria in a novel liner made of the rejected fraction of fine aggregates and plastic waste. Adopting such a bio-barrier between the liner and the drainage system could reduce both the leachate flow and the contaminants concentrations that actually reach the liner. This is because the natural clogging of the bio-barrier would reduce its permeability, and the physicochemical and biochemical processes would enhance their attenuation. In this regard, the proposed project will 1) develop bio-barriers for landfill design, combining the rejected fraction of fine aggregates, plastic waste and biofilm-forming bacteria, 2) verify the long-term performance of these new designs for representative conditions, and 3) develop guidance for real-world implementation to reduce barrier permeability and increase contaminant attenuation. The bio-barrier (BioBar) approach has not been quantitatively tested for landfill barrier design and merges innovative geochemical concepts and biofilm engineering. The effectiveness of the developed bio-barrier could enable the reduction of clay liner thickness, in a renewable and sustainable design perspective.

Mots clés : bio barrier landfill design biological clogging geochemical modeling

Participants :
- Université autonome de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
- Université de Copenhague (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet FIREPROD (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Tropical fires release large amounts of particles, including essential nutrients. The trade winds can transport these nutrients across vast distances, depositing them in tropical rainforests and potentially enhancing their primary productivity. However, the link between fire and rainforest productivity remains unclear. This project aims to examine the influence of fire emissions on the productivity of tropical rainforests using satellite remote sensing. To achieve this, I will map burned areas and fire emissions in the pan-tropical region using high-resolution satellite data and machine learning techniques. Subsequently, I will employ a transport model to determine the trajectories of fire particles in the atmosphere and estimate their deposition on the surface of tropical forests. Finally, I will analyse the impact of nutrient deposition on primary productivity and biomass of tropical rainforests using three satellite products: 1) leaf area index (obtained from optical data), 2) sun-induced fluorescence (emitted by plants during photosynthesis), and 3) vegetation optical depth (a radar-based indicator of vegetation biomass). To handle the substantial volume of satellite data (>100 terabytes), I will use a cloud-based platform with powerful computational capabilities. This processing will generate valuable geospatial datasets, including annual maps of burned areas, fire emissions, and nutrient deposition in the pan-tropical region, as well as trend maps depicting rainforest productivity. This interdisciplinary project combines expertise in remote sensing, fire ecology, atmospheric transport, nutrient cycling, and plant productivity, providing novel insights into the impact of fires on the carbon sequestration capacity of tropical rainforests.

Mots clés : remote sensing, tropical rainforest, plant productivity, atmospheric transport, nutrient deposition, carbon cycle, fire emissions, burned area mapping

Participants :
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
- Université de Copenhague (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SpinQc (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

26 EU nations have signed a declaration on 5th December 2023 to make Europe a global leader in quantum technology. Spintronics, a key component to the advancement of quantum computation, are mainly explored in inorganic solids which suffer from high density and limited chemical tunability. Through SpinQc with Politecnico di Milano as my host, I aim to develop a ‘quantitative superexchange (SE) model’ to establish new rules that go beyond classical Goodenough-Kanamori-Anderson (GKA) rules-applicable only to ceramics. These rules will explain SE mechanism mediated by ligands that interact with metals through ionic/covalent bonding in magnetic coordination polymers (CP). In SpinQc, I will study parameters such as ground spin-state of metal, frontier molecular orbital (FMO) of ligand and framework topology and their respective control over SE in magnetic CPs through the following steps- i) Synthesis of high-quality single crystals and pure powder samples of reported magnetic CPs, ii) Determination of unprecedented experimental wavefunction on CP single crystals from X-ray wavefunction refinement method using accurate high resolution single crystal X-ray diffraction data. From these experimental wavefunctions, I will determine precise number of electrons exchanged due to overlap between metal d-orbitals and ligand FMO; iii) Modification in the magnetic nature of CP upon pressure application. I will use high-pressure X-ray crystallography to investigate changes in framework topology that can affect the SE coupling and hence modifies the overall magnetic ordering. Further, I will employ high-pressure neutron diffraction to study the changes in magnetic moment under compression. I will exploit the research outcomes from SpinQc to formulate updated GKA rules and subsequently use them to design new spintronic materials. Through SpinQc, I will mark my contribution in the field of spintronics and start an independent research career in coordination network-based materials.


Participants :
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 193643.28 €
Projet reSET (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

Against the backdrop of a looming global environmental crisis, a sustainable energy transition driven by public and private finance and innovation paves the way for the emergence of novel technologies, industries, value chains, consumption patterns, etc., under a techno-economic paradigm that promises to lead to a ‘great surge of development’ decoupled from environmental harm. The diffusion and adoption of this new paradigm, however, seems to be too sluggish to avert ecological collapse, uncertain in view of geopolitical conflict and the impending energy crisis, and highly uneven in time and space due to core-periphery disparities. In Europe, this paradigm shift presents opportunities but also major challenges for peripheral regions, which necessitate more radical industrial strategies. This highly topical project will investigate from a theoretical, empirical and normative perspective the energy transition dynamics of Southern European regions, their institutional, technological and economic determinants, their economic and environmental impacts, and the policies needed for enabling these regions to forge their techno-industrial niches in the emerging value chains and to achieve green growth. The project will combine Schumpeterian, post-Keynesian and ecological economic theories under a ‘systemic’ research programme, and produce a cutting-edge formal model of a complex economic system embedded in the environment and undergoing energy transition. At the empirical level, it will employ advanced statistical and computational methods to test for the impacts of green technologies and to simulate alternative transition scenarios. At the normative level, it will frame the EU and national policy discourses on the European Industrial Strategy, Recovery Plan and Green Deal with evidence-based insights on industrial policy. The project is designed to boost the researcher’s career evolution and to consolidate his expertise and research skills through high-quality training.

Mots clés : sustainable energy transition techno economic paradigm shift complex economic system eco innovation ecological economic decoupling green growth core periphery divide industrial policy

Participants :
- Université de Lisbonne (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 156778.56 €
- Bard College (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École des hautes études en sciences sociales (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €