Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MultiStem (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The field of bioelectronics devices that can translate ionic signals in our bodies into electronic signals, is one of the most remarkable success stories of science and engineering over the last decades. Although such devices have been lifesavers (i.e. pacemakers, glucose meters), recent discoveries are about to change the entire pharmaceutical industry. Organic bioelectronics, devices based on biocompatible polymers, opening new horizons in biomedical engineering. Recent developments in 3D materials and devices show a tremendous potential to deliver human-like platforms for tissue growth, however, these devices are still in their infancy. This project aims to take a fundamental approach to designing composite materials with electrical and optical properties that may be used for a multitude of applications in biomedical engineering. The project proposes the realization of 3D multifunctional scaffolds for stem cell control by blending optically and electrically active biocompatible polymers. Beginning with films, to understand mixing and properties, the project will gain insight into how these materials may be used for biological applications. Subsequently, the materials will be prepared in 3D formats and used to host stem cells. The multifunctional properties of the proposed scaffolds will be used to determine the effect of electrical and optical cues on stem cell differentiation. Stem cells play a key role in tissue engineering medicine as they have already proven effective in developing new treatments. These highly biomimetic platforms and the fundamental knowledge produced in this project will be an invaluable tool to further progress with stem cell research towards therapeutic goals. As such, the outcomes of this proposal can, in the short term, benefit the field of organic bioelectronics by providing fundamental knowledge and a novel platform for a facile control of cell function and in the long term, can impact the global need for better treatment of diseases.

Mots clés : bioelectronics, organic bioelectronics, organic semiconductors, 3d conducting polymer scaffolds, mixed ionic electronic conduction

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 224933.76 €
Projet PAC Synthesis (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The field of immunotherapy has become one of the most promising strategies in fighting cancer. By using the incredible features our very own immune system already possesses, like the powerful tool of specific antibody-antigen recognition, a new generation of drugs can be generated. The idea of linking cytotoxic drugs to monoclonal antibodies with high affinities to specific tumor cells will tremendously improve drug delivery, as tumor-associated antigens can be found by antibodies and the high cytotoxicity of the conjugated drug is used to achieve efficient cancer treatment with less side effects. In this research proposal, we establish a new therapeutic platform that uniquely combines the advantages of two rapidly developing areas – immunotherapy and targeted protein degradation – by developing first class of PROTAC-Antibody Conjugates (PAC). The resulting novel therapeutic agents will help to overcome the limitations arising from lack of cell specificity of PROTACs by exploiting tissue-specificity of the antibody component. Several studies reported encouraging data for the treatment of acute myeloid leukemia (AML) with antibody drug conjugates (ADC) that target the myeloid antigen CD33. In addition, a functionalisable BET inhibitor will be employed in protein degrader construct, generating a new class of small-molecule BET protein degraders. Besides, the proposed self-immolative linker chemistry will allow the traceless realease of the PROTAC once the PAC is internalized into the target cell. Moreover, we will use novel site-selective cysteine bioconjugation approach to build homogenous conjugates that, unlike current examples built using maleimide chemistry, are fully stable in the blood. Overall, this approach will be applicable to any protein of interest and therefore has the potential to advance not only the AML treatment but also the whole field of cancer therapy.


Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet microMAGNETOFLUIDICS (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The field of microfluidics is providing answers to several key questions in biology. Specifically, microfluidic single-cell analysis yields important insights into the heterogeneity of cells that is crucial for cancer research, regenerative medicine and drug development. Microfluidics has also emerged as a powerful tool to study single bacteria and to address questions concerning antibiotic persistence and the role of the microbiome in protecting against modern plagues such as cancer, autoimmune diseases and obesity. Despite its great potential, microfluidic technologies have not been widely adopted in mainstream biomedical research since they require a great deal of external equipment, which is often difficult to operate by untrained personnel. The aim of this proposal is to simplify fluid handling and single-cell studies by developing a microfluidic device that includes magnetic microvalves. These microvalves can be wirelessly actuated to generate compartments and isolate single cells. The magnetic microvalves will be integrated by means of a very recently available lithographic tool based on two-photon polymerization (2PP) with sub-diffraction limit resolution, which enables the fabrication of polymer-based 3D micro- and nano-architectures. The microMAGNETOFLUIDICS project is strongly interdisciplinary in nature where physics, materials science, and biology are strongly intertwined. The innovative character of this proposal is unprecedented since no previous studies have been reported on 3D-printed magnetic microvalves operating within a microfluidic channel. The topic of the project is timely because it promotes the use of microfluidics among biologists and bacteriologists for decrypting cellular mechanisms at a single-cell level.

Mots clés : two photon polymerization, lab on a chip, femtosecond laser, 3d printing

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187419.6 €
Projet LARNUEXP (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : CLOSED

The field of neutrino physics is an exciting one to be involved in at the moment. Neutrinos are the most mysterious fundamental, interacting so weakly with other matter that they are elusive to measurements. They also offer the only known indicators of physics beyond the Standard Model. I will use this fellowship to build expertise in the technology that will define the future of the field of neutrino physics - the liquid argon time projection chamber (LAr-TPC). I will spend the outgoing phase at Fermilab, USA, installing and commissioning the SBND detector, and working with data from SBND and the existing MicroBooNE detector. I have a track-record of pioneering searches for new physics, and will continue this by searching for a new Z boson that could be an explanation for the g-2 anomaly. I will also capitalise on my involvement in the protoDUNE liquid argon test-beam experiment, taking the protoDUNE data and applying it to the SBND and MicroBooNE detector simulations, to bring a new level of precision to the experiment. I have particular expertise in the reconstruction of low-energy electromagnetic showers. I will combine this expertise with the new protoDUNE data to develop new algorithms to enable MicroBooNE and SBND to investigate the MiniBooNE low-energy excess and search for sterile neutrinos. In the return year, I will bring my expertise in LAr-TPC technology back to the UK, and take a leading role in setting up a major production site for making anode planes for the DUNE far detector.

Mots clés : neutrino oscillation detector instrumentation liquid argon time projection chamber

Participants :
- Fermi research alliance llc (Etats-Unis) — Partner, organization partner, Autres, subvention : 0.0 €
- University of Manchester (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 251857.8 €
Projet SENECA (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

The growth of cloud computing is phenomenal, with vendors experiencing yearly growth over 90%. This reflects the rate at which organizations and individuals are leaving the comfort of tried and tested solutions to move into promising but uncharted territory. The aim of SENECA is no less than to address key issues in the software engineering of cloud-based systems, including a disciplined approach to their development and operation. The project partners have pooled their considerable knowledge and experience to identify areas where applied research, industrial tests, as well as graduate-level training can deliver the most promising results. The main challenge associated with cloud-based systems is their quality, as characterized (following ISO 25010) by their functional suitability, security, reliability, usability, performance efficiency, maintainability, and portability. Important quality issues include: How can the quality of a software-defined cloud infrastructure be measured and assured? How can the security of a cloud-based system be ensured, taking into account that it may be running on an un-trusted infrastructure? How can the energy-efficiency and CO2 footprints of cloud-based applications be optimized? SENECA addresses this challenge along the axes of A) cloud-based products and B) the cloud development process and tools. Research along axis A reaches from extending “traditional” quality assurance techniques to the cloud environment, to techniques for optimizing energy consumption by cloud systems without compromising performance or reliability. Research along axis B reaches from combining theory and practice to allow construction of secure systems on top of insecure cloud infrastructures, to improving testing practices for cloud development. Additionally SENECA pursues objectives to train recruited fellows on conducting industry-motivated research and to create joint supervision structures among industry and academia in the software engineering community.

Mots clés : cloud computing, quality assurance, energy efficiency, cyber security

Participants :
- SingularLogic (Greece) (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 484773.84 €
- King Juan Carlos University (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 247872.96 €
- Bitergium sll (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 495745.92 €
- Athens University of Economics and Business (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 242386.92 €
- Delft University of Technology (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255374.28 €
- Software improvement group bv (Pays-Bas) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 510748.56 €
Projet MOCCA (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

The growth of the Photonics market and the great potential of Photonics in addressing global challenges creates a huge demand in innovative solutions and qualified experts with multidisciplinary skills in photonics and micro- and nano-technologies, able to advance photonic technologies towards applications ranging from spectroscopy to LIDARs. EID MOCCA responds to the huge demand of qualified experts, by providing for 4 early-stage researchers (ESRs) a world-class advanced training programme (TP), which will bring them to the level of the next generation of leaders in the field of photonics. The TP will be implemented through the unique combination of the “hands-on” research training, non-academic placements and advanced inter/multidisciplinary/inter-sectoral training, to attain scientific skills (nonlinear optics and laser physics, micro- and nano-technologies) and transferable skills. These are provided by the synergistic merging of the expertise of 3 academic, 2 non-academic beneficiaries and 1 non-academic and 2 academic partners from 4 countries. This will equip ESRs with a unique exprtise required to address global challenges such as global warming, improving accuracy of medical diagnostics, precision metrology and autonomous driving etc. MOCCA underpins innovative technological development across the entire range of photonics-based disciplines: laser physics and engineering, micro- and nano-photonic components and circuits. The unique Research Programme addresses demand in innovative solutions by developing a new generation of optical frequency comb (OFC) techniques, based on the expertise of world-leading academic and industrial partners. Research outcomes will result in new products, services and markets, based on advancing OFC generators with required characteristics in science, industry, and healthcare. In the social context, the EID outcomes will lead to raised public awareness on the economic and social impact of OFC techniques.

Mots clés : optical frequency combs, nanotechnology, nonlinear science, lasers

Participants :
- Sapienza University of Rome (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 261499.68 €
- AMO (Germany) (Allemagne) — Partner, beneficiary, Autres, subvention : 252788.4 €
- RWTH Aachen University (Allemagne) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Thales group (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Aston University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
- Iii-v lab (France) — Partner, organization partner, Autres, subvention : 0.0 €
- Université Paris Cité (France) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 274802.04 €
Projet MIDGESYM (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The health of livestock is commonly impacted by viruses acquired from midge vectors. The viruses transferred following a midge bite cause considerable economic losses across the EU, making control of midges/midge vector competence a pressing concern. Recent research has indicated some inherited symbionts may alter the vector competence of their insect host, and thus represent viable means of interrupting pathogen transmission in natural populations. However, reduction of vector competence has only been considered for Wolbachia symbiont infections, and for viruses of importance to human health. Midges, in contrast, are commonly infected with a Cardinium heritable symbiont with unknown properties. This project seeks to establish tools for understanding this symbiont, and investigate whether it affects host immune system activity and vector competence following exposure to an infected blood meal. This proposal will thus provide both fundamental understanding of a poorly studied symbiont in an important host group, and, more practically, evaluate whether alteration of symbiont presence is a viable means of interrupting viral transmission.


Participants :
- University of Liverpool (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet MINORLEGMOB (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The heavy involvement of the EU in the field of minority rights during the EU enlargement process to Central Eastern Europe (CEE) fostered the impression that problems related to national minorities had been largely resolved by the time the respective states joined the Union. By contrast, recent research indicated that the level of minority rights protection seems to have stagnated or even deteriorated in the post-accession period, which is counterintuitive to the positive expectations that followed these countries’ EU integration. The argument put forth here is that scholarly accounts of minority rights in the region focus too much on the role of international protection while treating minority representatives as disempowered actors to be defended, and failing to consider their potential for action to assert the rights that formally belong to them. The project’s interdisciplinary approach, combining legal studies with political science, will produce the first account of the agency and legal mobilisation of minorities in CEE, moving forward the scholarly debate beyond the current emphasis on structural conditions. The proposed research will therefore investigate the situation of minority rights through the lens of litigation and legal mobilization in two new EU Member States, Romania and Hungary and an EU candidate country, Serbia. The proposed project addresses four major, closely inter-related research questions: Which rights these minorities have claimed through litigation and which they have not, and what could explain their activism in some cases as opposed to others? Which legal mobilization strategies have led to favourable court decisions, which have resulted in negative rulings and what are the main factors accounting for these outcomes? Why some rights given by law are not enforced in practice? Finally: what could be achieved through litigation concerning minority rights in terms of policy reform and social change?

Mots clés : national minorities, minority rights, litigation, legal mobilization, nationalism, central eastern europe, roma rights

Participants :
- Hellenic Foundation for European and Foreign Policy (Grèce) — Coordinator, beneficiary, Recherche, subvention : 165085.44 €
Projet SortAx (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The high morphological and functional polarization of neuronal processes relies on exquisite mechanisms to accurately sort and traffic proteins to their rightful location. It is therefore of no surprise that accurate formation and function of neuronal circuits depends on these trafficking mechanisms, which are indeed often impaired in neurodegenerative disorders and normal aging. During the past 30 years, researchers have been able to dissect the mechanisms required to target proteins to the dendritic plasma membrane, however our understanding of the mechanisms underlying the axonal polarization of proteins is rather incomplete. In this regard, a growing number of studies, including my work, suggests that dendritic endosomes are key sorting stations to direct neuronal cargoes to the axon. Yet, the molecular machinery of intracellular trafficking and endosomal sorting required remains to be uncovered. In this proposal, I hypothesize that dendritic endosomes are key sorting stations for polarization of axonal cargoes. I therefore propose to elucidate the key axonal trafficking pathways of endogenous cargoes, the intracellular trafficking and endosomal machinery involved and assess their importance for axonal development and connectivity. Importantly, I will adopt an unbiased approach using cutting-edge technology to focus on the endogenous protein pool, which differs considerably from prior studies in the field, in which axonal trafficking route has been followed for a limited number of cargoes under overexpression conditions. Given that abnormal axonal trafficking increases susceptibility to neurodegenerative diseases, including Alzheimer´s and Parkinson, with this project I will also contribute to the design of new therapies to alleviate neurodegeneration by deciphering the molecular mechanisms of axonal cargo trafficking.

Mots clés : neuronal polarity, endosomes, intracellular trafficking, axon

Participants :
- University of Coimbra (Portugal) — Coordinator, beneficiary, Recherche, subvention : 147815.04 €
Projet MOMIMIC (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The high stability of components like cellulose limit the efficiency and cost effectiveness of biofuel or chemical production from lignocellulosic biomass. Thus, the ability of the recently discovered class of metalloenzymes, lytic polysaccharide monooxygenases (LPMO), to enhance the efficiency of recalcitrant polysaccharide degradation makes understanding these enzymes invaluable for carbon friendly sustainable chemical and energy development as prioritized under the Horizon2020 program. The current project seeks to develop multi-layered biomimetics of the LPMO active site that can offer unprecedented replication first and second coordination sphere groups, in order to be able to rationally study the collection of interactions that contribute to enzyme activity. The research involves the design and chemical synthesis of aromatic oligoamide scaffolds that incorporate a specific copper binding site. Through synthetic modification of the scaffold to alter the second coordination sphere, and combined spectroscopic and electrochemical methods, changes in the properties and reactivity of the metal site will be studied with a goal of developing a structure- function relationship that can assist in guiding enzyme modification, as well as, new synthetic catalyst development. The applicant has a strong background in synthetic chemistry and mechanistic studies that will be crucial to the success of the project. Through joining the host lab in Belgium that specializes in coordination and supramolecular chemistry, she will greatly increase her own knowledge base, while transferring her knowledge of synthetic organic chemistry to the host. Additionally, during proposed secondments to work with a collaborator in Germany for the electrochemical studies, the applicant will further expand the gain and transfer of knowledge and strengthen international collaboration between the groups involved.

Mots clés : second coordination sphere interactions, biomimetics

Participants :
- Université Catholique de Louvain (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160800.0 €