Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet WildRice (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The 370 million indigenous people in the world make up 5% of the total population, yet they constitute one third of the 900 million extremely poor rural people. Indigenous women are affected disproportionately by these hardships as they struggle to provide healthy food for their families. Indigenous peoples’ traditional food is a critical, yet deeply compromised, dimension of their culture, health and well-being. In Europe and around the world, food sovereignty is being embraced by scientists, social movements and some governments as a framework that can be used to realise more sustainable and just food systems. Food sovereignty, in the indigenous North American context, involves a re-connection to traditional land-based food and political systems. While an emergent body of research has begun to chart out indigenous food sovereignty, this is an embryonic field. This fellowship will focus on the hitherto under-examined gendered dynamics of access to natural resources in indigenous food sovereignty. Dr. Jessica Milgroom will analyse how the indigenous-led revitalisation of wild rice, a culturally important food for the Ojibwe people of the Upper Great Lakes area of the United States, has become an important strategy to assert control of natural resources and work towards food sovereignty. Using a feminist political ecology perspective, the project will explore the historical and current patterns of control of access to wild rice by Ojibwe people. The project will be hosted by the largest centre in the world focusing on food sovereignty and will be co-produced with indigenous communities using an innovative, transdisciplinary research approach that combines western and indigenous research methods. Dr. Milgroom will expand her experience in transdisciplinarity, her expertise in food sovereignty and feminist political ecology, and by leading a major research project will be well positioned to restart her career as a high-level researcher in Europe after a career break.

Mots clés : colonial and post colonial history, food systems, access, natural resources

Participants :
- Coventry University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 337400.64 €
Projet ASIMIA (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

The ASIMIA technical objectives aim to improve the predictive capabilities of current aerodynamic simulation tools in industry, based on Computational Fluid Dynamics (CFD), by applying High Order Methods (HOM) instead of current second order approximations. HOM for CFD has a strong potential towards higher reliability of the predicted results, leading to enhanced design process, lower costs and reduced time-to-market of challenging future designs. It is generally considered that HOM could form the next generation of industrial CFD tools, but the competitiveness and adequacy of the HOM approaches for CFD has still to be demonstrated for industrial applications. ASIMIA aims at removing some of the current limitations for high-fidelity industrial applications, leading to a new generation of CFD tools with a high level of efficiency and maturity. NUMECA, an innovative SME acting as CFD and multiphysics software developer is joining with the Center for Numerical Simulation of the School of Aeronautics at Universidad Polytecnica Madrid (UPM) and three Industrial Partners from three different sectors, Aviation with AIRBUS, Car Aerodynamics with McLAREN F1 and Industrial Appliance Industry with DYSON, to lead 5 doctorates towards innovative simulation methods and relevant industrial applications. In addition, ASIMIA will • consolidate a joint PhD training program to foster research in the areas of contemporary fluid dynamics and multiphysics numerical simulation • improve the transfer of knowledge between academia, SME's and industry, establishing a long- term collaboration and dissemination strategy • enhance the preparation of highly trained and skilled young engineers to careers in the high-tech industries • enhance researchers career perspectives in numerical simulation, through the transfer of developed algorithms into industrial CFD codes, learning hereby about the requirements of the software industry in terms of quality, robustness and reliability

Mots clés : computational fluid dynamics, high order methods

Participants :
- Numerical Mechanics Applications International (Belgium) (Belgique) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 640800.0 €
- McLaren Honda (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Universidad Politécnica de Madrid (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 627262.2 €
- Airbus (Spain) (Espagne) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Dyson (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet MECHANOCHECK (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The ATR protein kinase controls the DNA damage response (DDR), with ATM, Chk1 and Chk2. DDR genes are often mutated in cancer cells and act as an anti-cancer barrier in response to oncogenic stimuli. ATR is essential and protects the integrity of replicating chromosomes, prevents fragile site expression and aberrant condensation events. The Foiani laboratory recently found that ATR associates with the nuclear envelope during S phase and prophase and in response to osmotic or mechanical stress. Moreover, ATR-defective cells exhibit aberrant chromatin condensation and nuclear envelope breakdown. These observations prompted us to suggest that the ATR-mediated mechanical response enables cells to cope with the mechanical stress induced by topological transitions through the modulation of nuclear plasticity and chromatin association to the nuclear envelope. However, the molecular mechanism and functional relevance of ATR-mediated mechanical response remain unclear. Mechanosensing occurs primarily through the actin cytoskeleton, which forms the cellular mechanical system linking the extracellular microenvironment to the nucleus. We aim at understanding the connections between the ATR-mediated mechanotransduction pathway and actin modulation in response to mechanical stress. Our working hypothesis is that ATR may be part of an integrated response to mechanical stress that has a more general role in controlling cell and nuclear plasticity through the modulation of actin cytoskeleton and nuclear events. To address these questions, we will employ and develop various multidisciplinary approaches including state-of-the-art Atomic Force Microscopy (AFM), micropatterned protein substrate, novel microfluidic device and accompanied with advanced molecular biology techniques in order to quantitatively and systematically explore the ATR mediated mechanotransduction.

Mots clés : dna damage response, mechanotransduction, genome instability

Participants :
- FIRC Institute of Molecular Oncology (Italie) — Coordinator, beneficiary, Recherche, subvention : 180277.2 €
Projet PLIOTRANS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The Antarctic and Greenland ice sheets will be significant contributors to sea-level rise during and beyond this century. An increase in sea level will have considerable impact on ecosystems, the vulnerability of the coast and on society. A better understanding of the responses of the ice sheets to a warming climate is needed to make more rigorous predictions of the impact of regional sea-level variations. The Late Pliocene (3.264 to 3.025 million years before present) was a warm interval in the history of the Earth that can be used to gain a better understanding of the response of the ice sheets to a warming climate. Within PLIOTRANS, I will use a unique ice-sheet - sea-level numerical model and couple this to a high-end numerical climate model for the Late Pliocene to for the first time simulate the time varying climate and ice volume simultaneously. My expertise with ice-sheet and regional sea-level modelling and the vast knowledge on Pliocene climate modelling and data at the participating organisations will definitely create the optimal environment to deliver the objectives of. The fellowship will be highly beneficial to establish myself as an independent researcher. With this innovative modelling framework I will improve the understanding of the sensitivity of the Greenland and Antarctic ice sheets to the warmer then present day climate of the Late Pliocene, to reduce the uncertainties associated with future projections of sea-level change. Geological data for the data-rich last glacial cycle will be integrated into the modelling framework to serve as a constraint on modelled sea-level change over the globe. Accordingly, combining models and data will reduce model uncertainties of sea-level change. The outcome of PLIOTRANS can be used as a benchmark for climate scientists and policy-makers in further reducing uncertainties in future targets for greenhouse gas emissions and the impact of ice-sheet melting within future climate projections.

Mots clés : model development, ice sheets, sea level, antarctica, greenland

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet DecipherBILU (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The BILU syndrome is an autosomal dominant primary immunodeficiency that combines B cells Immunodeficiency, Limb abnormalities and Urogenital malformations. Recently, we discovered the genetic basis of this disorder using whole exome sequencing. The causative mutation affects the protein that is involved in mediating transcriptional responses after activation of nuclear receptors (e.g. sex hormone receptors). Altered signalling via nuclear receptors is likely to impact a wide range of genes implicated in development, homeostasis and metabolism leading to the BILU syndrome. In this proposal, we develop a strategy to characterize the impact of the newly discovered mutation on nuclear receptor signalling. We will use analysis of patients’ primary fibroblasts, induced pluripotent stem (iPS) cells and CRISPR-Cas9 edited cell lines to investigate how the mutation impacts transcriptional responses after hormonal stimulations. This project will give insights in the function of the newly identified protein that is involved in the BILU syndrome and will help to understand its broader role in regulation of gene transcription.


Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet BIOCLIMA (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The BIOCLIMA project will explore the impact of climate change on microbial biodiversity in semi-enclosed basins in order to decipher ecosystem response to environmental crises, at a temporal scale much longer than that of human life. The Late Miocene Messinian Salinity Crisis (MSC) will serve as case study. This dramatic paleoceanographic event resulted in the establishment of harsh conditions (eutrophication, hypersalinity and anoxia) at the scale of a whole marine basin, which was lethal for most eukaryotes but allowed some extremophile prokaryotes to flourish. The BIOCLIMA project will address two main aspects: 1) Tempo and modes of climate variability recorded by MSC sediments. The project will investigate the sedimentary cyclicity recorded by Messinian deposits (carbonates, sulfates, and shales), which was related to climate oscillations at various time scales. 2) The microbial community structures and the modes of adaptation of the microorganisms that inhabited the paleo-Mediterranean at the advent of and during the MSC, allowing to identify the response of microbial life to climate-controlled environmental change. The project will be based on a multidisciplinary approach, applying cutting-edge sedimentological, geochemical, and geomicrobiological methods. The wider impacts of BIOCLIMA are: i) a contribution to our understanding of the biological adaptation to environmental crises; ii) establishing a catalogue of biosignatures in evaporites that will help to recognize and classify past life in ancient extreme environments on Earth and Mars. The Fellow will greatly benefit from the training in state-of-the-art methods of Organic Geochemistry and Geomicrobiology in Vienna, and increase his analytical skills in the Petrology and Geochemistry of evaporites during a secondment at the University of Barcelona.

Mots clés : evaporites, geomicrobiology, climate change, extreme conditions, messinian salinity crisis

Participants :
- Universität Hamburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171460.8 €
- University of Vienna (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet BP3 (Horizon 2020, appel à projets 2017)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

The Beatriu de Pinos programme (BP) has been running successfully since 2005 and aims to promote postdoctoral research and transnational mobility in all fields of research in Catalonia. The grant will be three years long and will enable outstanding junior researchers from all nationalities to train and conduct research in any Catalan excellence research group on a project of their choice. The main objectives of the BP3 project are: a) enable the transition towards a consolidated research career attracting 120 of junior postdoctoral researchers over 5 years, multiplying each one’s skills sets and networks via targeted Career Development Plans and mentoring; b) improve the quality of postdoctoral research training; c) and increase the competitiveness of the Catalan scientific community and for extension the European one. The long term objective of BP3 is to significantly contribute to the career development of more researchers and qualified future independent leaders. The Cofund contribution will be used to add one more year to the grant, increase the number of fellowships and the líving and research and mobility allowances and provide better career opportunities and favourable working conditions in accordance with the European Charter of Researchers. Besides high level interdisciplinary scientific research training, researchers will receive additional training in complementary skills and a special personalize career development support will also be given during and after the grant finishes. Intersectoral secondments will be fostered, not only to private industry but also to the public and government sector as all of them are crucial contributors to a knowledge based society. Catalonia has fostered a successful research and knowledge hub in the south of Europe in a relatively short time and provides the postdoctoral researcher the best environment to deepen scientific skills and develop new ones. The programme is driven by AGAUR.

Mots clés : catalonia, incoming mobility, all scientific domains, all nationalities, postdoctoral talent, researcher s independence, interdisciplinarity, intersectorality, excellence, public research institutions

Participants :
- Government of Catalonia (Espagne) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 7858800.0 €
Projet BSBL (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : TERMINATED

The Bolton Library, newly housed at the University of Limerick (UL), is one of Ireland’s most important private library collections. It is currently part of a major conservation effort aimed at saving the books from decades of damage. However, some of the earliest books are too fragile for conservators to handle easily. My project pilots a new application of micro computed x-ray tomography (µCT) that will facilitate the conservation of these important books while revealing new information about the history of the Irish book. I have four main aims: first, to examine the bindings of the medieval books in the library in order to learn more about the cultural and intellectual contexts of book production and collection during early English colonialism. Second, to position these books within a global network of trade in materials and craft techniques. Third, to pilot a novel use of µCT in special collections care, particularly as a means of understanding the status and structure of fragile items in order to plan treatment. Finally, to establish a network of scholars to support further studies in book science in Ireland and internationally. The research takes place in three overlapping phases detailed in my work packages. All of the medieval books in the library will be assessed and catalogued during the data collection phase. Suitable books will be selected for µCT imaging at UL’s Bernal Institute. Processing of the primary data takes place in a second phase, when any further lines of scientific enquiry will be pursued. In the second year I will translate this quantitative data into qualitative argument. Guided by new analytical approaches, my project will reveal the full significance of the materials and structures that medieval books in Ireland comprise: advancing a new holistic account of the history of the book in Ireland, and its participation in global networks of trade and production. Here regionally specific techniques are embedded in their international conte

Mots clés : book science, binding history, fragmentology, micro computed x ray tomorography, biocodicology, bioarchaeology, cultural history, local history, global turn, trade, materials, material science

Participants :
- University of Limerick (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184590.72 €
Projet BonE-GraphT (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The BonE-GraphT aims to develop a new approach, based on bone template engineering using which the entire load-bearing structure might be possible to regenerate for replacing the damaged bone. The proposed approach, once developed, will be possible to align with the tissue-engineering bio-reactor technology for in-theatre use, which may be able to meet the demand for current shortage in treating the damaged load-bearing long bones (e.g. tibia femur) in trauma, osteoporotic bones and other bone defects. Within my research I am going to develop a new biomaterial: Calcium Phosphate coated graphene composite on porous Ti-alloy substrate via pulsed laser deposition techniques for enabling biocompatibility via osteoconductive process, promoted via progenitor stem cells. For research training as an orthopaedic materials engineer within which I aim to solve orthopaedic defects as a global problem I will deal with the following Research Training Activities (RTAs); i) Ti-alloy based graphene/calcium phosphate materials processing using femtosecond PLD; ii) Characterization of bio-active materials surface; iii) Characterization of cell cultivation, toxicity, attachment and mineralization; iv) Design of model bone structure. This training is not only beneficial for the my scientific career development, but also for the host institute (the University of Leeds) and the general public health. The above listed training activities will be supplemented by a number of non-Technical skills for my career development. As a result of this cross-disciplinary project the fellow will be a well-rounded biomaterials research engineer who will be in future qualified for perusing an academic career at the University of Leeds in the area of advanced biomaterials for tissue engineering and drug delivery. Necessary research training and supervision at the UoL will be provided by the Engineering supervisor Prof. Animesh Jha (AJ) and the clinical supervisor Prof. Peter. V. Giannoudis (PVG).

Mots clés : bone materials, graphene, tissue engineering, femtosecond lasers, pulsed laser deposition, biomaterials, bone composites, biomechanics

Participants :
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet CORALCARE (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The CORALCARE project studies the genetic response of corals to ocean warming. The world’s coral reefs are being severely impacted on a global scale by rising temperature that has led to increased coral bleaching and mortality. It is uncertain that these unique ecosystems will be able to adapt to this unprecedented pace of warming. Coral reefs are often referred as the ‘rainforest of the ocean’ and their potential loss puts an astounding EUR 9 trillion of biodiversity and ecosystem services at risk annually. The major goal for the management of coral reefs is to both predict the ability of natural coral populations to adapt to future climate change and to assist this evolution, in order to minimise their loss. However, assisted evolution requires a deep understanding of coral genetics, which is still in its infancy. This is why the overarching project aim is to understand genes and pathways that lead to thermal tolerance in corals. For the first time in the world, the cutting-edge genome-editing CRISPR/Cas9 and CRISPR/dCas9 techniques will be developed in corals, and allow us to disrupt gene function as well as turn genes on or off, to identify thermotolerance-related functions. The project aim will be tackled by: (1) scaling-up the CRISPR/Cas9 method for high-throughput gene editing during the short annual coral spawning, and establishing the CRISPR/dCas9 method for gene regulation in corals; (2) editing corals using the two CRISPR methods to test the function of candidate genes. The research is topical and highly innovative in using CRISPR genetic engineering for functional genomics, which will strengthen Europe’s quality and attractiveness in R&I. To undertake this research, the early-career researcher who has expertise in evolutionary biology will receive training in CRISPR by world’s experts, and transfer knowledge to EU. This groundbreaking project will establish the Fellow as a prominent coral scientist who will lead Australian-French collaborative research.

Mots clés : acropora millepora, australia great barrier reef, climate change, coral larvae, crispr, electroporation, gene regulation, genetic adaptation, new caledonia lagoon, rna sequencing

Participants :
- Australian Government (Australie) — Partner, organization partner, Recherche, subvention : 0.0 €
- Institut de recherche pour le développement (France) — Coordinator, beneficiary, Recherche, subvention : 281827.2 €