Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet PALMERA (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

PALMERA will address the low power and fault tolerant cache memory design bottleneck through a combination of hardware and software approaches. The proposal has two research directions: (1) Develop a cache memory hardware equipped with novel circuit designs to keep the reliability during voltage scaling. (2) Leverage the software application level to manage energy consumption. A methodology will be developed that enables the programmer to identify non-critical data structures and program phases that are not memory-bound. Through a system scenario design methodology, this information is used to manage the settings of the underlying novel hardware to increase error resilience and save energy. The focus is on memories implemented for embedded systems in areas such as medical imaging and space applications, typically having strict requirements for both energy consumption and reliability. These types of applications are increasingly becoming multitasked and dynamic; hence, data intensive and fluctuating with respect to resource requirements. Available static analysis and worst-case design margins cannot any longer meet the power and reliability constraints. Compared to previous techniques that typically focus on either hardware or software when optimizing for both energy and reliability, PALMERA adopts a multidisciplinary holistic approach where hardware and software levels of the system are combined. Working towards these challenging project goals not only moves the research front forward, but also gives the Experienced Researcher excellent opportunity to develop her skills and career potential. The combination of PALMERA research, with high quality training at the host institution and during secondment, strengthens her knowledge and experience and provides the best opportunity for her to gain a position as a senior researcher in industry or academia. The goal is for PALMERA to be an enabler for the next step, being a proposal for a European Research Council grant.

Mots clés : low power circuit and system design, high performance, fault tolerance, resilience, cache memory design, vlsi, embedded systems, system scenario technique, software engineering

Participants :
- Norwegian University of Science and Technology (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 208400.4 €
Projet PERICLeS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

PERICLeS target is to develop a new technology in the field of optoelectronics by taking advantage of the exceptional optical and electronic properties of hybrid perovskite semiconductors. The ultimate achievement will be the demonstration of a proof-of-concept solution processed, solid state perovskite-based electrically injected laser with high spectral tunability and low lasing threshold; such device goes beyond the state of the art of the current technologies and will represent a breakthrough in the field, with major impact in communications, sensing, medicine and consumer equipment. The project will start from the design and synthesis of suitable multidimensional perovskites to combine in a single material solution processability, flexibility, high luminescence quantum yield and good charge transport properties. The newly engineered materials will be integrated in laser cavities to confine the electromagnetic field and obtain high Q-factors with excellent control over the spatial and spectral characteristics of the laser beam. Electrically pumped lasing will be achieved through the implementation of the perovskite/resonator system in electroluminescent devices with low fabrication cost and highly compatible with the existing technologies. Beyond the main target, the project will proceed through the realization of intermediate, high impact targets which include the synthesis of new hybrid perovskites with excellent optoelectronic properties, their advanced photophysical characterization and the fabrication of high-efficiency light emitting diodes and transistors. This multidisciplinary project will be carried out at the Italian Institute of Technology (Milan) under the supervision of Dr. Annamaria Petrozza and complemented with a secondment in the nanofabrication facilities at AMO (Aachen).

Mots clés : hybrid perovskites, electrically pumped laser, spectroscopic techniques, synthesis of solid state semiconductors

Participants :
- Italian Institute of Technology (Italie) — Coordinator, beneficiary, Recherche, subvention : 183473.28 €
Projet PROS-VARIANT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

PIK3CA-related overgrowth spectrum (PROS) is a group of rare congenital disorders that manifest as complex syndromes with overgrowth of several tissues (vasculature, adipose and muscle tissues, bones, brain and skin among others) or as localized lesions such as vascular malformations. PROS is caused by somatic activating mutations in the PIK3CA gene that arise postzigotically during embryonic development. Patients suffer dramatic functional and life-threatening complications and typically require extensive mutilating surgery, pulsed laser, and/or sclerotherapy. However, these treatment strategies are insufficient, and patients commonly experience a high risk of recurrence and progression. This is in part a reflection of poor understanding of the underlying cellular and molecular mechanism of their onset and progression. In this proposal, I aim to gain physiological and molecular insight into PROS and address fundamental biological questions concerning when (timing), where (cell linage), who (PIK3CA variant) and how (triggered mechanism) activating PIK3CA variants contribute to the development and severity of PROS. I will address the following key objectives: 1) identify the specific molecular and cellular alterations triggered by strong (H1047R) and weak (E726K) activating PIK3CA variants and 2) characterize their spatiotemporal pathogenesis in PROS using novel mice models. To this end, a combination of in vitro and in vivo approaches, using novel genetically modified mice will be implemented in order to provide new mechanistic insight into the underlying disease pathology and give rise to new preclinical models to test therapeutic treatments. Achieving these goals will strongly contribute to my training as international expert in PI3K signaling, cell biology and congenital diseases, my experimental skillset, and my development towards a well-embedded and independent researcher within European academia.

Mots clés : pi3k, endothelial cells, pre clinical animal models

Participants :
- Fundación Josep Carreras Contra la Leucemia (Espagne) — Coordinator, beneficiary, Recherche, subvention : 160932.48 €
Projet PLASMIONICO (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

PLASMIONICO is an innovative proposal aiming at advancing sustainable energy production by developing a "cold-cathode" thermionic generator as key component of novel photovoltaic/thermoelectric (PV/TE) hybrid devices to outperform the solar cell and thermoelectric generator working separately. The cold cathode, instead of being brought to extremely high temperatures, produces the emission of electrons by the absorption of infrared (IR) photons in the unused region of the solar spectrum below the PV cell bandgap. The IR photons will launch plasmons at a nanostructured metallic cathode, which upon relaxation will generate a photocurrent. A great advantage is that plasmon-resonance driven thermionic emission is not restricted to a particular class of materials, working for Si-based devices as well as for organic (soft and flexible) materials, since the cathode temperature is that of a working solar cell. Research activities will span the whole added-value chain from fundamental studies of materials for thermionic generation, including the optimization of plasmonic nanostructures, reaching higher TRLs by realization of a thermionic demonstrator. PLASMIONICO would contribute to the current energy challenge, a priority in both the EU and ICMAB-CSIC research agendas. The proposal possesses high interdisciplinary character by merging activities in physics, chemistry, materials science and device technology, which together with the unique network of international partners will contribute to boost the track records and develop the career of the applicant.

Mots clés : solar energy conversion, thermionic emission, plasmon resonance, hot electrons, photovoltaic thermoelectric, hybrid device

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 172932.48 €
Projet POLINGO (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

POLINGO maps, analyses and theorizes the contribution of informal interpersonal networks to shaping the policies, programmes, and approaches of international non-governmental organisations (INGOs) in the international governance of crisis areas, particularly post-war states. By accompanying, complementing or even contradicting institutional linkages between state and non-state agencies, interpersonal networks transcend and bypass the conventional divide between governmental and non-governmental organisations. Since INGOs predominantly rely on their reputations as independent, disinterested and impartial to be able to work in post-war states, these closely knit interpersonal networks between state and non-state institutions raise questions regarding the sources and construction of legitimate INGO authority and credibility in global governance. Despite the ubiquity of such informal interpersonal networks, there has not been any systematic attempt to study their role in shaping, enabling or transcending institutional structures and means of cooperation in the global governance of post-war states. POLINGO addresses this gap by combining a longitudinal Social Network Analysis (SNA) with two in-depth qualitative case studies. The project breaks new ground theoretically and empirically by studying the institutional and interpersonal/informal interfaces between non-state and state-based forms of power in global governance as summarized in the following overarching research question: How do interpersonal networks between state- and non-state agencies shape INGO practices and positions in the global governance of post-war states?

Mots clés : mixed methods social network analysis, ingos, individual agency, legitimacy, post war governance

Participants :
- Aberystwyth University (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet PORTable STaNDOuTs (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

PORTable STaNDOuTs aims to develop a multiple Organs-on-a-Chip (MOOC) microfluidic device integrated with electrodes for carrying out Transepithelial electrical resistance (TEER) measurements. The key motivation for adopting such an approach is to develop a rapid, versatile and cost-effective prototype with ability for real-time monitoring to replace the conventional long and cost-ineffective preclinical procedures involved in the drug development process. On administration of an oral pharmaceutical drug, major organs that are involved in the absorption and metabolism of drug are intestine and liver. The drug is then distributed to different target organs such as brain, heart, lung, etc. Finally, the drug metabolites are eliminated from the human system with the help of kidney. Additionally, it has also been found that certain drug metabolites produced by the liver cause non-target drug induced organ toxicity. TEER measurement is a rapid and non-invasive technique for the real-time detection of pathophysiology. TEER indicates the integrity of the cell membrane barrier of different organs that is necessary for maintaining homeostasis within the human body. In view of this, we intend to fabricate a physiologically-mimicking perfused intestine-liver-kidney microfluidic chip with provision for carrying out in-chip TEER measurements. The device will be designed to consist of three compartments for organs namely, intestine, liver and kidney, independently equipped with electrodes for measuring TEER values to detect the integrity of cell membrane barriers in each organ compartment. The developed device will be then subsequently validated for its ability to study drug-induced nephrotoxity. Furthermore, the device will also be made versatile to incorporate other organs of interest to study non-target organ toxicity. Thus, the developed MOOC microfluidic device will surely boost the drug development process that will successively improve the health security of the society.

Mots clés : organs on a chip, transepithelial resistance  teer

Participants :
- Cherry Biotech (France) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 184707.84 €
Projet PROSPER (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

PROSPER is an interdisciplinary project that seeks to understand the politics of rule-making in the global trade regime. It primarily aims to examine how the growth of internationalization of production networks enables private actors – i.e. multinational companies (MNCs) – to be active in the shaping of international economic policies, such as trade agreements and regulatory standards. PROSPER will primarily investigate the extent to which MNCs are able to orchestrate political mobilization of their subsidiaries for coordinated lobbying and impose rules and standards upon firms along their supply chains. Applying international political economy (IPE) insights from the fields of political science, economics, and international law, the projects proposes that firms’ globalization strategies and their degree of integration into global production networks significantly affect their ability to be active in shaping global rules and standards. In order to test the empirical implications of the proposed theory, PROSPER will employ a mixed-method research design using quantitative analysis and in-depth case studies. The project will construct a comprehensive new dataset of MNCs and triangulate the results achieved through statistical analysis via comparative cases studies. As a result, by combining insights from political science, economics, and international law, the project will help us understand the dynamics of economic globalization and the role of private actors in the global trade governance.

Mots clés : global value chains  gvcs, regulatory standards, trade policy, preferential trade agreements  ptas

Participants :
- University of Bern (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet BIO-Banana IN and OUT (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Panama disease is a devastating disease of banana caused by the fungus Fusarium oxysporum f.sp. cubense. A new race called tropical race 4 (TR4) is estimated to threaten >80% of the world’s bananas and can cause up to 100% yield loss. The disease is detrimental to global banana production, but also for small-holder farmers especially in Africa, because Panama disease also affects plantain cultivars that provide food for approximately 400 million people. In the 1950s, Panama Disease almost wiped out commercial banana cultivation in Central America. Because the fungus is a vascular pathogen, there is no effective way of combating the disease with crop protection compounds. In addition, the fungus can persist in the soil for many years. Traditional breeding of banana is time consuming and has had only limited success in delivering acceptable cultivars and effective resistance. The key objectives of this proposal are to employ state-of-the-arts biotechnological solutions such as genome editing using CRISPR/Cas and high-throughput resistance gene engineering to introduce a resistance gene and deactivate a susceptibility gene in banana with the global aim of creating a banana cultivar that is resistant to Panama disease.

Mots clés : banana, genome editing, panama disease, fusarium oxysporum, resistance engineering, crispr, pathogen resistance, plant breeding

Participants :
- Sainsbury Laboratory (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 183454.8 €
Projet ePANC-SPLICE (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Pancreatic beta cells are highly specialized cells that play a key role in maintaining glucose homeostasis by secreting insulin. Dysfunction or loss of beta cells results in diabetes, a worldwide growing epidemic. Extensive research has started to uncover the signals and transcriptional networks that control specification, differentiation and maturity of the different pancreatic cell lineages, and in particular of beta cells. However, posttranscriptional regulation during pancreas development has remained mostly unexplored. Alternative splicing (AS) is the main posttranscriptional mechanism that generates transcriptomic and proteomic diversity, playing essential roles in cell specification and functional specialization. My previous data suggest that beta cells activate neuron-related splicing programs involved in the regulation of insulin secretion. Moreover, pro-inflammatory cytokines (mediators of beta cell failure in type 1 diabetes) affect the splicing of signaling and pro-apoptotic genes that determine beta cell survival. However, the presence of beta- or endocrine-specific splicing programs and their role in diabetes remains to be clarified. In this project, we will investigate the regulation and function of endocrine-specific alternative exons. I will combine comparative transcriptomics, biochemical and functional studies, iPCS reprogramming and zebrafish knock-outs to: (i) comprehensively identify endocrine-AS exons, and study their regulation during beta cell differentiation and pancreas development; (ii) probe the phenotypic impact of endocrine-AS programs on beta cell differentiation and function; and (iii) Investigate the role of ENDO-AS exons in remodeling transcriptional and signaling networks involved in diabetes. We foresee that this project will provide new insights into beta cell pathophysiology and generate valuable knowledge for the development of splicing-modulating therapies and disease biomarkers.

Mots clés : alternative splicing, microexons, rna binding proteins, pancreatic beta cells, diabetes, insulin secretion, pancreas development, endocrine cells

Participants :
- Centre for Genomic Regulation (Espagne) — Coordinator, beneficiary, Recherche, subvention : 172932.48 €
Projet PolyBar (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Parametric polymorphism is an ubiquitous paradigm in programming. It permits writing generic algorithms that can be used on several datatypes, thus reducing the duplication of code and producing safer software. System F is a very simple polymorphic programming language suited to the theoretical study of polymorphism. From the point of view of mathematical logic, System F corresponds to the theory of second-order Peano arithmetic (PA2), which in turn is a sub-theory of first-order Peano arithmetic with the axiom of countable choice (PA-AC). On the other hand, PA-AC can be computationally interpreted using the non-polymorphic programming language System T extended with the bar recursion operator (System TBR). The PolyBar project will turn the logical translation of PA2 to PA-AC into a computational translation from System F to System TBR. This translation will improve the state-of-the-art by extending the use of well-known proof techniques to polymorphic programming languages and promote the use of these languages in environments where safety is important, like medical software or autonomous car systems. Computer programmers will be able to use the sophisticated features of polymorphism and still prove correctness properties on their programs. The PolyBar project will be carried out by the experienced researcher who worked during his PhD thesis on computational interpretations of PA-AC using System TBR, and recently gave the first connections with PA2 and System F. The experienced researcher will collaborate with a supervisor who has a strong background in type theories (including System F) and in correspondences between various mathematical theories and programming languages. Working in France, where System F was discovered and is still a subject of intense research by many experts in the field, the experienced researcher will make the beneficiary benefit from his experience in the UK, which has a strong community on recursion theory and denotational semantics.

Mots clés : lambda calculus, realizability, bar recursion

Participants :
- Université Paris Cité (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185076.0 €
Projet STRATASCAPE (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Passive continental margins make up many of the world’s densely populated coasts, hold 35% of the world’s largest oil reservoirs, sequester carbon, and are critical biodiversity hotspots. Human populations and infrastructure on passive margins are at risk from sea level rise, increased storm intensity, and sediment starvation. The geologic evolution of passive margins around the world is poorly understood due to a lack of models that couple terrestrial erosion with sediment deposition in the deep marine environment. The Atlantic Passive Margin (APM) of the eastern United States is exceptionally enigmatic; debate centers on how many (if any) pulses of exhumation occurred on the APM since the opening of the Atlantic Ocean 200 million years ago. Yet there has been no attempt to use mechanistic surface process models to extract APM exhumation history. I propose to build a new, coupled model of terrestrial and marine sediment transport and use it to invert the rich deep marine sedimentary record for APM exhumation history. I will develop a new model for continent-scale deep marine seascape and stratigraphy evolution over geologic time, which I will couple with existing models for terrestrial and shallow marine environments. I will validate the new model against an existing small-scale stratigraphy model as well as stratigraphy from the Bay of Biscay and the Ogooué Delta, Gabon. I will use the coupled model to invert the deep marine sedimentary record and resolve APM exhumation history over the past 200 Ma. Inversion results will provide novel constraints on the number, timing, and cause of exhumation pulses, and will be compared against thermochronologic data and geodynamic models. This approach is the first to quantitatively link the development of marine stratigraphy to APM landscape change. The proposed study will unlock the potential of deep marine deposits, the most complete sedimentary archives on Earth, to yield time-resolved records of changes to Earth’s surface.

Mots clés : surface processes modelling, stratigraphy modelling, landscape evolution, atlantic passive margin, model inversion

Participants :
- Helmholtz Centre Potsdam - GFZ German Research Centre for Geosciences (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 162806.4 €