Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet secretPOL (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The Salazar regime was the longest-lasting dictatorship in Europe in the Twentieth Century. If the Military Dictatorship from which it emerged is taken into account, it lasted 48 years, from 1926 to 1974. Like the other dictatorships born in the inter-war years, it relied heavily on its secret police (PIDE) for stability. This research programme aims to reconceptualise the relation between the PIDE and Portuguese society in order to reach a more complete understanding of the regime’s exceptional durability. By drawing on developments in the international bibliography of totalitarianisms, of everyday life under a dictatorship, and of denunciatory practices, it challenges the established interpretative paradigm which sees the relation between the PIDE and society almost exclusively as one of top-down repression imposed upon a nation of passive victims. Its core argument is that the relation between the PIDE and Portuguese society was far more multi-facetted, dynamic and interactive than has been acknowledged until now. This research project posits as its main underlying thesis the notion that the Salazarist system was normalised by many Portuguese citizens as part of the structure of everyday life. Society adapted to the institutional framework imposed by the regime - including the secret police -, acting on the opportunities that opened up rather than remaining dependent or passive. If the role of society in the perpetuation of the Salazarist order is to be duly assessed, the framework of interaction between society and the secret police must be apprehended with recourse to a novel analytical prism (focusing on ordinary citizens instead of on the small minority of oppositionists who have monopolised the attention of historians so far), new research methodologies (oral history and opinion surveying) and original archival material (the letters of denunciation held at the PIDE Archives in Lisbon).

Mots clés : portugal, salazar dictatorship, secret police  pide, accusatory practices, self policing, denunciation

Participants :
- University of Lisbon (Portugal) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 147815.04 €
Projet sigNal (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The Salt Overly Sensitive (SOS) pathway is one of the main regulatory systems responsible for Na homeostasis in plants. The SOS pathway is activated by salt stress and comprises three core components: SOS1, SOS2 and SOS3. SOS3 is a calcium (Ca) sensor that perceives the increase of intracellular Ca triggered by salt stress and recruits SOS2, a Ser/Thr protein kinase, to the PM. The complex activates protein SOS1 by phosphorylation, a PM-localized Na/H antiporter that prevents the accumulation of Na to toxic levels and regulates Na partition between roots and shoots. Cytosolic free Ca is a common second messenger in the signalling of a variety of abiotic stresses. The wide range of Ca-activated responses lead us to posit the existence of additional mechanisms relaying input signals that, together with this Ca signature, would initiate the specific response for a particular stress. The hypothesis of my proposal is that the increase in intracellular Na concentration provokes the alkalinisation of the intracellular pH, what would be sensed by SOS3. SOS3 would work as pH and Ca sensor, which would integrate this pH shift and the Ca signature to activate SOS pathway. To support the hypothesis of cytosolic alkalinisation as a salt stress signal and SOS3 as a Ca and pH sensor, two experimental criteria must be meet: (1) salinity should induce an alkaline pH shift in plant cells, and (2) structural determinants of pH-sensing should be demonstrated in SOS3. To achieve my goal: (1) I will use a system, improved by Prof. Schumacher’s group, which allows the visualisation of pH changes in selected subcellular localisations through fluorescence ratio imaging experiments; and (2) I will use the technics learned and used duiring my postdoct stage to study whether SOS3 interactions and/or activity are pH dependent. This research will provide a new paradigm of how sodicity is sensed by plant cells.

Mots clés : abiotic stress, salt stress, ph sensing, ph sensor, sos3, sos pathway

Participants :
- Heidelberg University (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 171460.8 €
Projet SEA METAL FLUX (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The Samail Ophiolite in Oman is the largest and best preserved fragment of oceanic lithosphere on land, exposing otherwise inaccessible crust and mantle. It hosts 20+ Volcanogenic Massive Sulfide (VMS) deposits which are an important source of base metals and revenue for the country. Here I propose a new research pathway that uses the Samail ophiolite to unravel magmatic-hydrothermal processes leading to the formation of VMS deposits. Current studies suggest that the flux of metals to generate VMS may be provided by leaching of magmatic sulfides from the sub-volcanic units, but the role of magmatic oxides is poorly understood. Also, evidence that hydrothermal circulation in ophiolites reaches the crust-mantle transition demands an assessment of the bulk crustal metal budget. The Oman Drilling Project (ODP) is an international effort that provided drill-core sampling of the Samail ophiolite. My aim is to seize the timely synergies between the ODP and my ongoing studies of VMS, and investigate for the first time, the metal fluxes in a complete profile of oceanic crust to constrain VMS formation. To achieve this I will: 1) disentangle the factors that contribute to VMS metal signatures using mineralogy and trace element/multi-isotope geochemistry; 2) characterise the primary metallic mineral phases in the crustal profile to establish the metal budget available for cycling; 3) trace fluid pathways using cutting edge multiple S and Sr isotopes; and 4) deliver an integrative numerical model for metal cycling in the oceanic crust. The proposal builds on my multidisciplinary research experience bridging metallogeny and petrology in mafic systems, my VMS investigations and a multi-institution partnership that will consolidate my research profile and yield a significant knowledge transfer to my country. The results emerging from this MSCA can establish innovative mineral exploration guides, particularly for critical metals, adding value to land and sea hosted VMS deposits.

Mots clés : metal cycling, oceanic crust, volcanogenic massive sulfides, oman drilling project, critical metals

Participants :
- Fciencias.id - associacao para a investigacao e desenvolvimento de ciencias (Portugal) — Coordinator, beneficiary, Recherche, subvention : 159815.04 €
Projet SIFRm (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The Semantic Indexing of French Biomedical Data Resources (SIFR - www.lirmm.fr/sifr) project investigates the scientific and technical challenges in building ontology-based services to leverage biomedical ontologies and terminologies in indexing, mining and retrieval of biomedical data. We will build and improve an ontology-based indexing workflow (Annotator) similar to what exists for English but specialized for other EU languages, starting with French. This will be the first step in offering semantic and multilingual search and mining of biomedical data resources. Our main goal is to enable straightforward use of ontologies freeing health researchers to deal with knowledge engineering or multilingualism issues and to concentrate on biological/medical challenges. SIFR (2013-2017) is a collaborative action between LIRMM & BMIR currently mainly funded by the French National Research Agency (ANR) Young Researcher program. This proposal (SIFRm) aims to fund the mobility of Dr. Clement Jonquet, SIFR’s principal investigator, assistant professor at LIRMM, to Stanford University. Stanford BMIR, head by Pr. Musen, is a worldwide leader providing (English-)ontology-based services to assist health professionals in the design of biomedical knowledge-based systems. BMIR is the birthplace of tools such as Protégé or BioPortal and scientific methodologies such as data driven medicine that Dr. Jonquet will acquire and reuse in a multilingual (e.g., French) and multidisciplinary (e.g., agronomy) context. During the return phase, a secondment is planned within INRIA ZENITH team, head by Dr. Valudriez, renown for distributed big data management. SIFRm will enable development of innovating scientific services to make annotation goes beyond English and reach another level in terms of variety and amount of data, e.g., French electronic health records. The project is a great career opportunity and guarantees a 2-way knowledge transfer between EU & US (informatics & biomedical skills).

Mots clés : biomedical informatics, ontologies, semantic annotation, knowledge representation, text mining, data integration, semantic web, multilingualism, semantic indexing, big data, personalized medicine

Participants :
- Université de Montpellier (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 264668.4 €
- Stanford University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet SPATULA (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The U-Th dating system is broadly exploited to determine the timing and process of Earth’s geological, environmental, and biotic evolution for materials as young as few years to over the last 800 thousand years (kyrs). Contemporary solution phase U-Th dating protocol using thermal ionization mass spectrometry (TIMS) or multi collector-inductively coupled plasma mass spectrometric (MC-ICPMS) can provide high precision dates with errors of ±1-4‰ (2σ) on ages from 5 to 100s kyr; however, it still restricted by the discrete milli-domain (mm) sampling strategy and the time-consuming chemical preparation procedure. Laser ablation-inductively coupled plasma mass spectrometric (LA-ICPMS) could serve the strengths of rapid, in-situ, and high lateral scanning to U-Th dating. Until nowadays laser U-Th dating approach is sparsely reported due to its reduced sensitivity and precision. Here the experience researcher (ER) designs and employs methods by means of a solution-based correction strategy with a jet-interface setup. This new configuration could essentially reduce the uncertainties and enhance the sensitivity significantly. Based on the ER's previous training, he has firm knowledge and skills in conducting high precision carbonate U-Th dating protocol using MC-ICPMS (Shen, Wu et al., Geochim. Cosmochim. Acta, 2012), and the anlaysis of rare earth elements using LA-ICPMS (Wu et al., Anal. Chim. Acta, 2018). The expected outputs of this SPATULA project are: 1) improve the resolution of age assignments from the milli-domain (mm) to micro-domain (μm). 2) provide in situ analysis using LA-ICPMS to overcome time-consuming element separation processes requiring hazardous chemicals. 3) apply this μm-domain laser U-Th dating approach to tephra-containing stalagmite samples, to reconstruct high resolution volcaican eruption profiles. This sensitive, spatially U-Th dating approach, has the potential to be applied to diverse fields such as oceanograpgy, geomagnetics, and archaeology.

Mots clés : isotopic u th dating, la icpms, carbonates

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203149.44 €
Projet MARSS-5G (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The United Nations International Telecommunications Union (ITU) has recently reported that the number of mobile users is expected to surpass the world population. In fact, it is expected that by 2020 mobile users will exceed an astonishing 9 Billion subscribers. With this unprecedented market penetration and growth, many communication engineering challenges are anticipated. In particular, next generation 5G wireless systems must be designed using sophisticated and innovative strategies and techniques. While 5G applications are expected to be diverse, the network architectures and devices need to ensure and deliver reliable, pervasive, and high-speed interconnection for various data-intensive applications (e.g., interactive multimedia streaming). These requirements must be accomplished while necessitating limited resources for a continuously expanding consumer demographics. Thus, deploying such complex networks is a formidable engineering feat that requires novel ways of modeling, evaluating, and designing extremely dense radio systems. This project aims, through the study of spatial geometry of randomly deployed mobile units, to develop several analytical tools to model, design, and analyze complex 5G networks, and validate them through experimental datasets. Ultimately, our broad goal is to conceptualize an engineering research idea, and then transitioning it into innovative applications that can be replicated for real-world cellular networks operated by established service providers and mobile manufacturers.

Mots clés : 5g networks, spatial modeling, stochastic geometry

Participants :
- Chalmers University of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173857.2 €
Projet IFatULB (Horizon 2020, appel à projets 2017)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

The Université libre de Bruxelles (ULB) is a world leading research institution in which a number of scientists have gained recognition from international panels, including 4 scientific Nobel Prizes and 23 ERC grants. IF@ULB is a comprehensive fellowship programme providing to experienced researchers the opportunity to conduct frontier research and receive diversified training and career guidance in an environment of scientific excellence with state-of-the-art facilities. Under the supervision of renowned academics, IF@ULB fellows will benefit from an extensive collaboration network with academic and non-academic institutions and the continuous support of the ULB administration. IF@ULB will propose three calls within a five-year programme. To impact the post-doctoral policy as widely as possible in the host institution, the project will be open to all fields of research. The recruitment will be organised through three panels: Social Sciences and Humanities, Physical and Engineering Sciences, and Life Sciences. For each call and each panel, IF@ULB will offer to fund 7 experienced researchers for their two-year projects, which amounts to 126 fellowship-years during the action. The proposed selection will be based on the practices implemented in the Marie Skłodowska-Curie Individual Fellowships and will comprise the following elements: support from a ULB academic staff member, a three-stage evaluation procedure on the basis of three evaluation criteria (excellence, impact, implementation) and a final ranking by the corresponding thematic panel. Moreover, IF@ULB proposes a comprehensive communication and dissemination plan at programme and project level. IF@ULB’s aim is to reinforce the international character of ULB by building up current experience on international fellowship programmes, to establish its role as a reference in research and training activities in Belgium and Europe, and thereby to strengthen human resources at both national and European levels.

Mots clés : post doctoral fellowship, experienced researcher, international research, training, career, development

Participants :
- Université Libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 4460400.0 €
Projet VIP-2 (Horizon 2020, appel à projets 2018)
Action : Cofund Postdoctoral programme
Statut du projet : SIGNED

The VBC International Postdoctoral Program (VIP2) sets new standards in postdoctoral training in the Life Sciences by providing talented young scientists with outstanding support to conduct ambitious research projects in an international, interdisciplinary, and inter-sectoral environment. The program fosters scientific independence, encourages groundbreaking, career-making projects, and enables fellows to establish valuable contacts to academic and non-academic sectors. The Vienna BioCenter (VBC) has a 30-year history of scientific excellence and training. Four academic institutes (IMP, IMBA, GMI, MFPL) form the basis of this application. They are devoted to basic research in all areas of Life Science. Research topics range from structural biology to organismal biology, from gene expression to neurobiology, from microbiology to molecular medicine which encompass the full range of model systems from microbes, stem cells, plants, invertebrates to vertebrates. Together with 21 biotech companies, the VBC is Austria’s largest life sciences research center and a stellar example of an interdisciplinary and inter-sectoral campus. VIP2 is a 3-year postdoctoral fellowship program open to candidates with backgrounds in biology, chemistry, physics, medicine, engineering and computer science. The selection is a bottom-up procedure where fellows select two mentors and conceive a research project that forms the basis for the selection. VIP2 fosters scientific independence by selecting projects that have the potential to develop into distinct research lines and by providing candidates access to outstanding scientific core facilities. VIP2 fellows are mentored through a structured program that trains fellows for skills required to attain high-level positions in different scientific sectors. Finally, fellows can obtain direct insight into non-academic sectors through a secondment and are supported by an external advisory board with members from various non-academic sectors.

Mots clés : life science, molecular biology, structural biology, rna biology, epigenetics, stem cells, cell, biology, signalling, molecular medicine, neurobiology, model organisms, career development, experience

Participants :
- Research Institute of Molecular Pathology (Autriche) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 4965300.0 €
Projet IRONBIND (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The ability of phytoplankton to access the micronutrient iron fuels vast marine ecosystems, drives biogeochemical cycles and influences climate on a planetary scale. Recent studies in the model diatom Phaeodactylum tricornutum have revealed that high-affinity iron uptake uses a carbonate-dependent phytotransferrin which is highly sensitive to ocean acidification. This project seeks to validate and extend the hypothesis that ocean acidification negatively affects the growth of marine phytoplankton by interfering with this carbonate sensitive uptake mechanism. The influence of acidification on iron uptake rates will be characterized in a number of environmentally relevant and phylogenetically diverse strains of phytoplankton, and results will be confirmed using a combination of reverse genetics and environmental validation. The resulting chemical, biological and rate-constant data will be integrated into large-scale biogeochemical Ocean General Circulation Models, which will allow us to place these results into ecological context. This project will transfer cutting-edge molecular techniques and genomic analyses to the host institution while training the experienced researcher in key analytical and biogeochemical modeling methods. Capacity-building courses in project management and opportunities for communication are planned to further develop the future potential of the researcher. Because of the outsized role that iron-limited phytoplankton have in biogeochemical cycles and the sequestration of carbon dioxide, the multidisciplinary outputs of this action are expected to be of high impact and broad interest to a wide array of disciplines, including biogeochemists, climate modelers, policy makers and resource managers.

Mots clés : ocean acidification, phytoplankton, iron uptake, diatom, biogeochemistry

Participants :
- Alfred Wegener Institute for Polar and Marine Research (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 87403.2 €
Projet PULVAD (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The ability of the failing human heart to recover after mechanical unloading with left ventricular assist devices (LVADs) has been insufficiently exploited. To fill this void, we engineered the Pressure Unloading LVAD (PULVAD) system, designed to promote myocardial recovery. The overall objective of the proposed translational investigation is to evaluate the feasibility, safety and efficacy of this innovative pressure unloading approach as a bridge to recovery from heart failure. We will first investigate the effects of short-term PULVAD support on systemic hemodynamics and left ventricular mechanoenergetics in a large animal model of acute heart failure. We will then perform a pivotal randomized controlled study to investigate the safety and efficacy of long-term PULVAD support in promoting sustained cardiac recovery in a large animal model of chronic heart failure. If validated, this new technology has the potential to improve quality of life and ease the socioeconomic burden of advanced heart failure. In addition, histological, cellular and molecular analysis of paired myocardial biopsies obtained pre/post-PULVAD unloading will provide insight into mechanisms underlying cardiac reverse remodeling and myocardial recovery.

Mots clés : mechanical circulatory support, left ventricular assist device, lvad, cardiac unloading, heart failure, remodeling, reverse remodeling

Participants :
- National and Kapodistrian University of Athens (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 164653.2 €