Projet UNLIMITED (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

The UNLIMITED project addresses the critical challenges of lipid immunometabolism, a rapidly emerging field with transformative potential for treating immune-mediated diseases such as cancer, autoimmunity and metabolic disorders. Lipid metabolism has been recently recognized as a regulator of immune cell function, yet the intricate interactions between lipid pathways and immune responses within tissue-specific microenvironments remain poorly understood. This knowledge gap hampers the development of precision therapies tailored to the metabolic needs of immune cells in diverse tissue niches. To tackle these challenges, UNLIMITED will train 15 Doctoral Candidates in cutting-edge interdisciplinary research, equipping them with expertise spanning immunology, bioinformatics, metabolism, and drug development. A key feature of UNLIMITED training programme is the integration of leading-edge methodologies, such as multi-omics machine learning, single-cell technologies, CRISPR-Cas9, and spatial metabolomics, alongside groundbreaking techniques pioneered by consortium partners, including SCENITH, Met-Flow, click-chemistry, LIPSTIC, and advanced lipidomics. UNLIMITED’s training program emphasizes a holistic, interdisciplinary approach, providing DCs with technical skills, unparalleled expertise, and transferable competencies to thrive in academic and industrial sectors. The project will unlock unprecedented insights into how lipid metabolic pathways regulate immune cell function and adapt to changes in the tissue microenvironment. This knowledge will enable the identification of novel therapeutic targets and pioneering precision therapies for immune-related diseases. This bold initiative strengthens Europe’s leadership in health innovation, creating a new generation of highly skilled researchers ready to transform global healthcare and advance therapeutic frontiers.

Mots clés : lipid immunometabolism, adaptive immunity, innate immunity and inflammation, drug development

Participants :
- Sanofi (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Biocrates Life Sciences (Austria) (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Johannes-Gutenberg de Mayence (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 580544.64 €
- Université de Cologne (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 290272.32 €
- Vugene uab (Lituanie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 269195.76 €
- Trinity College (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 341087.04 €
- Université Johannes-Gutenberg de Mayence (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Samplix aps (Danemark) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de médecine de Vienne (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 302542.92 €
- Sitryx therapeutics ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 348738.12 €
- Université libre d'Amsterdam (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 314669.16 €
- Sonja noss (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Actitrexx gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Leiden University Medical Center (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 305285.76 €
- Université d'Aberdeen (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Milan (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281755.08 €
- Amsterdam University Medical Centers (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 305285.76 €
- Luxembourg Institute of Health (Luxembourg) — Partner, beneficiary, Recherche, subvention : 288540.0 €
- Université de Vilnius (Lituanie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Aix-Marseille Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Tress academic gbr (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Ministry of Health (Espagne) — Partner, beneficiary, Recherche, subvention : 282188.16 €
- Université de Padoue (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281755.08 €
- Université du Luxembourg (Luxembourg) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université technique Carolo-Wilhelmina de Brunswick (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 290272.32 €
- Université autonome de Madrid (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €