Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SPOTTER (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

G-quadruplex structures (G4s) are gaining attention due to their widespread presence in the human genome, featuring over 700,000 identified sequences. These stable G4s are often found in critical areas of our DNA, such as telomeres, gene promoters, and regions linked to repeat expansions in diseases.  However, when investigating their biological function, multimolecular G-quadruplexes (mG4s) have been often overlooked and deemed unlikely to be physiologically relevant, with the bulk of recent advances on G4-biology almost exclusively focused on unimolecular G-quadriplexes (uG4s).  SPOTTER aims to fill this critical gap in the biology of mG4, by generating a selective probe that is currently missing to study these structures. Specifically, in this proposal, an aptamer-based probe that can be tuned to interact exclusively with mG4s will be developed.This tool will facilitate live-cell imaging and genome-wide mapping of mG4s for the very first time. This will further allow me to explore the role of mG4 formed in guanine-rich RNA repeat expansions, which could trigger formation of insoluble aggregates that are relevant to neurodegenerative diseases, such as in amyotrophic lateral sclerosis (ALS).

Mots clés : aptamers, g quadruplexes, als, chemical biology, nucleic acids, peg

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet INOV (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Economic Sciences
Statut du projet : SIGNED

The Inov project aims to estimate the causal impact of firm innovation on productivity (revenue and technical efficiency), output prices, and markups using state-of-the-art microeconomic techniques. The project also aims to understand the economic mechanisms behind this relation and discuss, to what extent they could benefit firms and consumers. At last, we test if there are aggregate implications arising from innovation outcomes related to its role in changing the allocation of resources in the economy. Important contributions and novelty of this project are to show the causal impact of firm innovation while taking into account the riskiness of R&D, identify the impact on output prices, product market concentration, markups, and firm efficiency of successful innovation. In addition, it explains these findings by exploring a set of economic mechanisms such as: i) the role of product reallocation, ii) the persistency of innovation, iii) complementary hypothesis across innovation types, and iv) the role of international trade (exports and imports). At last, it shows that innovation might have implications for the aggregate economy in terms of generating misallocation.

Mots clés : research and development expenditures, innovation, firm, products, prices, efficiency, markups

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 130173.96 €
Projet DSBSRS3DPT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

To achieve an ambitious goal of carbon-neutral Europe by 2050, a new generation of double-sided stainless-clad bimetallic steel (SC) manufactured from cutting-edge 3D printing techniques (WAAM) was developed and investigated in this project, which has promising potential for engineering applications in demanding environments. It typically consists of a substrate layer (mild steel) and two clad layers (stainless steel), which combines the excellent corrosion resistance of stainless steel with the high strength and low cost of conventional mild (CM) steel. The combination of bimetallic steel and 3D printing not only reduces material cost but also minimizes the environmental impact. However, no studies or design standards are available in the literature for such member. This issue is addressed herein. The aim of this project is to develop the innovative WAAM double-sided SC bimetallic steel systems through the testing, numerical analysis and theoretical methods. To achieve this, a series of full-scale laboratory tests will be conducted, including cyclic loading tests, stub column tests, shear tests, bonding tests, and residual stress tests. Following this, a novel numerical modelling technique will be developed to generate a wide range of database. Also, a novel framework will be developed for shape optimization of such members. Finally, a new design approach based on modified European standards (EN 1993-1-4+A1) (2015), along with open-source software, will be proposed, which provides a more accurate strength prediction. The expected outcomes will result in significant economic, social and environmental benefits to European Commission’ construction sector by developing the next-generation 3D printing-based bimetallic steel resilient structures, contributing toward net-zero carbon emissions. This fellowship can serve as a stepping-stone in the fellow’s career, advancing his goal of making a meaningful impact on both society and the global construction industry.

Mots clés : stainless steel bimetallic steel 3d printing technique

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet WAVES (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

This project focuses on integrating floating offshore wind turbines (FOWT) with wave energy converters (WEC) to simultaneously harness offshore wind and wave energy. The specific objectives are: (1) to gain an understanding of the interactions between the FOWT, WEC, and surrounding flow fields, and to explore the nonlinear vibrations of the FOWT-WEC system; (2) to thoroughly assess the serviceability and safety performances of the FOWT-WEC system under both operational and extreme conditions; and (3) to develop innovative vibration control techniques aimed at effectively reducing responses of the FOWT-WEC system. To achieve these objectives, a multi-body model will be developed and integrated with aerodynamics, hydrodynamics, and structural dynamics computational modules to simulate the coupled dynamics of the FOWT-WEC system. Optimal designs for the WECs in terms of numbers, shapes, and configurations will be conducted to maximize energy generation and reduce wave loads, with a thorough evaluation of the system’s serviceability and safety. Given the space constraints and changes in structural dynamic characteristics, a novel pendulum inerter-based nonlinear energy sink will be designed to mitigate excessive vibrations within the FOWT-WEC system. The project will also incorporate comprehensive outreach and educational initiatives, including tutorials in STEM courses, engaging graduate and undergraduate students in research, and offering seminars and webinars to stakeholders. The research outcomes will contribute significantly to the creation of a new integrated wind and wave energy harvesting paradigm with the consequent reduction of energy costs on both national and global levels. This fellowship will provide substantial support in achieving the researcher’s future academic and professional goals.

Mots clés : floating offshore wind turbines, wave energy converters, coupled dynamics, structural vibration control

Participants :
- Imperial College London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet HowMOW (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Heat and salt are major components of the thermohaline circulation of the global conveyor belt as they regulate the masses of water bodies and and hence ocean-climate dynamics. The thermohaline circulation (THC) has played a significant role in the past climate extremes such as the onset of the Northern Hemisphere Glaciation. Although the temperature component of the THC can be extracted applying various methods such as foraminiferal magnesium/calcium thermometry and alkenone thermometry, salinity information of past seawaters is still among the unknowns in paleoclimate studies due to the lack of a direct paleosalinity proxy. Thus the role of one important salt contributor, the Mediterranean Outflow Water, to the deeper levels of the THC during major climate shifts in the geological record is scarcely documented. To that extent, this research proposal aims at establishing and exploring a new proxy that will allow to extract information on past salinity changes in seawater from deep-sea benthic foraminifers. As second step, I will investigate the role of the Mediterranean Outflow Water in the THC and the shift in ocean-climate dynamics during a well-documented major climate shift, i.e., the Early-Middle Pleistocene Transition (1.2-0.7 Million years ago), when the 41-kyr glacial-interglacial cycles were replaced with 100-kyr abrupt cycles. Execution of this project will allow me to enhance my scientific portfolio by learning a new technical instrument, joining a new research group in an internationally fast-growing research center, having the opportunity to manage my own research budget, and benefitting from the experience of the chosen supervisor, which are positive impacts for an early career scientist in becoming an established independent researcher.

Mots clés : foraminifers, trace elements, mediterranean sea, empt, paleosalinity

Participants :
- Université de l'Algarve (Portugal) — Coordinator, beneficiary, Recherche, subvention : 172618.56 €
Projet MIM-TBC (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Among conventional power generation systems, gas turbine (GT)-based technologies provide the optimal balance between reliability, affordability, and, most importantly, flexibility in the face of a substantial proportion of variable renewable energies (VREs). In response to intermittent VREs, the operational profile of GT will shift towards higher ramp rates, more frequent peak-load/base-load cyclic operations, and a greater number of start-ups which will negatively affect the life cycle of hot components. On the other hand, to enhance efficiency, the turbine inlet temperature should increase from the current 1500℃ to 1800℃, exceeding the temperature limit of high-performance superalloys (1300℃) and imparting the severest thermo-mechanical loading on hot gas path components being coated with indispensable overlay or diffusion type thermal barrier coating (TBC) systems. Owing to the multifaceted and severe consequences of protective coatings failure, research to predict interrelated deformation, chemo-thermo-mechanical degradation and subsequent failure of TBC systems particularly under high-temperature thermal cycling is a top priority. Experimental durability tests, which are primarily based on empirical fitting of coatings mass loss data, are incapable of predicting the lifetime and long-term degradation of a TBC system. In light of the above circumstances, it is extremely beneficial to develop comprehensive modeling techniques that are capable of replacing time-intensive and limited-scope experimental endeavors. Among the different options available, MCrAlY-YSZ (with M being Ni or Co) arises as the most common protective coating system. MIM-TBC project aims at developing a mechanistic and microstructure-sensitive framework for predicting deformation, damage progression, and lifetime of the MCrAlY-YSZ TBC system. Specifically, the framework will be organized to achieve the following specific objectives: O1) A microstructure-sensitive framework for deformation analysis of MCrAlY-based TBC system under thermal cycling O2) Physically-based lifetime prediction of MCrAlY-based TBC system under thermal cycling.

Mots clés : thermal barrier coating, crystal plasticity fast fourier transform, phase field modeling, damage, deformation

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet UTIFE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

UTIFE aims at further developing ultrafine eutectic Ti-Fe-based alloys to increase their maturity using selective laser melting (SLM) additive manufacturing. The project will characterize the alloys by using advanced tomographic techniques to determine their composition-processing-microstructure-property relationships, increasing the understanding of the eutectic Ti-Fe alloy system and the effects of processing parameters during SLM on eutectic alloys as a whole. The objectives of the project are to i) explore material SLM processing parameters to obtain crack-free samples with a high material density, ii) study and understand the mechanisms of crack formation, porosity generation and/or healing during the printing process, and iii) provide a multiscale (nano to micro) 3D characterization of the material microstructure. These objectives will be met using the state-of-the-art laser powder bed fusion (LPBF) to process the eutectic alloys and determine the effects of processing parameters on the as-printed material. The material will also be printed using a state-of-the-art in-situ synchrotron Xray computed tomography (S-XCT) SLM replicator to characterize the effects of printing parameters on defect generation and microstructural evolution during printing. A full characterization using traditional and advanced characterization techniques in 2D (SEM-EBSD, TEM, XRD) and 3D (3D FIB-SEM-EBSD, TEM, XCT, S-XCT) will provide critical information about the composition-processing-microstructure relationships in the eutectic Ti-Fe alloys. This project will introduce new hierarchically-structured eutectic Ti-Fe-based alloys of high interest for industry and contribute to significant scientific insights between additive manufacturing processing parameters, eutectic microstructures, and material properties in the Ti-Fe alloy system. The insight from this project can help explore other eutectic alloy systems for the development of novel additive manufacturing materials.

Mots clés : additive manufacturing and advanced 3d 4d multiscale characterisation in situ synchrotron x ray computed tomography of high strength multiscale eutectic microstructure titanium iron alloys

Participants :
- Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (Allemagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet MetaLeish (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Metal nanoparticles have shown high efficacy against various pathogenic microorganisms, including antibiotic-resistant strains, being a very promising solution for the development of novel therapies. Leishmaniasis is a neglected tropical disease, caused by obligatory intracellular parasites of the Leishmania genus. In their human host, they thrive inside the acidic environment of parasitophorous vacuole of mononuclear phagocytic cells, such as macrophages. Leishmaniasis can manifest itself either through disfiguring skin lesions (cutaneous leishmaniasis), or by reaching the spleen, the liver or the bone marrow (visceral leishmaniasis). According to the World Health Organization (WHO), it threatens more than 350 million people worldwide. There is no vaccine, and current treatments are long and difficult, based on toxic, expensive drugs that are becoming ineffective due to the development of resistance. The MetaLeish project aims to develop a new treatment against leishmaniasis based on biodegradable metal nanoparticles (BMPs). Metals such as Zn and Mg are widely considered biocompatible, being biodegradable in the human body. Moreover, they possess antimicrobial properties and an immunomodulatory action. Due to their small size, these particles can reach the parasitophorous vacuole of an infected phagocytic cell, and kill the parasite. For this purpose, Zn and Mg BMPs will be produced through the spark discharge technique. Then, BMPs aggregation in PBS or cell culture medium will be optimized, if necessary through functionalization or encapsulation steps, in order to achieve a stable colloidal suspension to be applied in in vitro assays. Lastly, BMPs efficacy against Leishmania parasites internalized in phagocytic cells will be accessed, and the mechanisms through which they are internalized by infected-macrophage cells and exert their anti-Leishmania action will be thoroughly described.

Mots clés : biodegradable metals, leishmaniasis, spark discharge technique

Participants :
- Institut de santé Carlos III (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet M3TiAM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Patient-customized bone replacement implants with (micro)structural and mechanical properties tuned by design would constitute a major advance in the biomedical field. Classical metallurgical post-processing (e.g. annealing or hot-isostatic-pressing) offer an efficient way to modify metallic alloys microstructure and resulting properties. Hence, the combination of titanium alloys, scaffold structures, and additive manufacturing open promising avenues to produce custom implants that mimic natural bones and thus reduce the need for revision surgery. Moreover, modelling tools across scales are mature enough to simulate microstructural evolution and its effect on material properties, which could accelerate the design of high-quality, high-fidelity, affordable implants. The aim of M3TiAM project is to develop robust computational tools to predict the effect of post-processing treatments on microstructure and mechanical properties of additively manufactured scaffolds structures, in order to guide the design of novel Ti-based implants. To do so, multidisciplinary and multiscale theories will be combined into i) a process-sensitive structural module using phase-field modelling to predict phase evolution of biocompatible Ti alloys and ii) a structure-scaffold geometry-sensitive mechanical performance module using crystal-plasticity (microscale) and finite element (macroscale) models to predict the mechanical behaviour of bulk material and scaffold structures. The resulting computational framework will guide the design and optimisation of novel metallic implants, from the level of their microstructure to that of entire scaffold-based implants. The expected impact include: new insight into process-microstructure-properties in metallic alloys, new multi-scale and multi-physics coupling and upscaling strategies, accelerated adoption and deployment of additive manufacturing of scaffold implants for personalized medicine.

Mots clés : titanium alloys additive manufacturing microstructure mechanical properties modelling and simulations phase field crystal plasticity

Participants :
- Université nationale d'Irlande à Galway (Irlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
Projet M4MID (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Metal Organic Framework Mixed Matrix Materials (M4s) are prototyped for many applications such as separating membranes, drug delivery systems and fire-safe plastics. Like all composites, the premise of M4s is to achieve greater properties than those of their isolated components. Yet, the interface between the components determines whether the synergy between the components is achieved or the overall performance is diminished due to their incompatibility. In principle, the interface can be designed by selection and chemical modification of the components involved. However, in practice such design is a very challenging endeavor. Atomistic simulations can predict the structure of the interface, from which the component compatibility may be inferred. Similarly, mechanical testing of the composites may reveal some qualitative characteristics of the interface. Nevertheless, the throughput of these approaches is insufficient to screen the design space for the optimal M4s for various applications. This project aims at developing the capability to computationally design M4s with good mechanical properties. By employing machine learning techniques, we will be able predict the properties of the interface in a high-throughput manner. Similarly, our multi-scale models will establish quantitative relationships between the interfaces and the mechanical properties of the composites, which can be verified experimentally. To achieve these objectives, the Researcher will be provided training-through-research in high-throughput atomistic simulation workflows, material informatics and machine learning for material discovery as well as homogenization techniques and finite element approaches for multi-scale modeling. Moreover, this project will give the Researcher an opportunity to apply her expertise to explore the area of composite design in both basic science and industry-oriented perspective actively undertaken by IMDEA Material Institute.

Mots clés : material informatics, metal organic frameworks, composite materials, multiscale

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €