Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet IMPAM (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Rapid and sensitive analyte determination in small volumes is one of the main tasks in modern diagnostics for the development of miniaturized in vitro test systems. This is critically important for both health and environmental diagnostics. The traditional approach (ELISA) is a time-consuming multistep process with sensitivity limitations due to usually used planar supports for detection. In this project we intend to develop a new approach for biosensing based on porous antibody microparticles. For this purpose, the combination of a new technique to assemble porous particles at mild conditions (host know-how) and highly sensitive ELISA-based detection system (applicant know-how) will be used. The porous particles will work as a platform with two crucial features: i) specific immunochemical reactions are realized on highly developed particle surface, ii) separation and detection in small volumes (micrometer dimensions). We believe that the proposed approach may open new avenues in future for effective diagnostics.

Mots clés : microparticles, antibody, immunoassay, chemiluminescence, sensitivity

Participants :
- Fraunhofer Society (Allemagne) — Coordinator, beneficiary, Recherche, subvention : 159460.8 €
Projet ReFocuS 3.0 (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

ReFocuS 3.0 (Road to Friday of Science Third edition) project aims to substantially raise public awareness about importance and positive role of science for and in the society by bringing the researchers into the focus of the general public. This year, by using open to diversity as an overall theme, we will present the openness of science, sharing of knowledge and the concept “science is everywhere”. Within this concept, we will show the new dimensions in perceiving researchers and their role in society, increase public awareness on the positive role of research in and for the society and promote the involvement of citizens in science. The science is not only confined to labs, but it also permeates the things surrounding us, and most importantly science is open to diversity. We want to make people aware that everybody can contribute to science. This future direction of the science, open science, cannot be achieved without combining and involving not just several academic disciplines, but also non-academia. The project relies on diversity of all actors in the science networks: researchers of diverse backgrounds and areas of expertise, citizens as a new type of researchers, diverse research topics important for the society and diverse institutions involved in science. The activities will take place in the thus far biggest ReFocuS edition, involving 14 cities and 46 diverse venues, including research institutes, old streets and houses, museums, archaeological sites, fortress, science clubs, shopping malls, city parks and libraries. The true value is reflected in presenting the openness of science to diverse contributors, both people and institutions. The fact is that both science and society can benefit from diversity since diversity delivers different perspectives on the world. The diversity of partners in the project, both cultural and scientific institutions, will expand the general image of how and why science and researchers are important for society.

Mots clés : diversity, open science, multidisciplinarity, scitizen science

Participants :
- Centar za Promociju Nauke (Serbie) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 43625.0 €
- Prirodno matematicki fakultet (Serbie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 29875.0 €
- Institut za bioloska istrazivanja (Serbie) — Partner, beneficiary, Recherche, subvention : 36025.0 €
- Zavod za zastitu spomenika kulture kragujevac (Serbie) — Partner, beneficiary, Recherche, subvention : 16625.0 €
Projet ReN2014-15 (Horizon 2020, appel à projets 2014)
Action : European Researchers' Night
Statut du projet : CLOSED

ReN2014-5 events will be organized during 2014 and 2015 and will take place in six major cities: i) Athens, Greece’s capital, ii) Thessaloniki, iii) Patras, iv) Heraklion, v) Volos and for the first time in vi) Corfu, the capital of the Ionian Islands. These cities are spread almost nation-wide and cover more than two-thirds of Greece’s total population ensuring a first-hand experience of ReN2014-5 activities from a large audience. The consortium consists of prestigious universities and research centres which over the years have built extended networks that ensure maximum visibility of the events. TV, Radio spots and interviews of highly-profiled researchers are foreseen, at national level, spreading the messages throughout the country while, at local level, apart from traditional communication ways of promotions, other innovative ones, such as the “taxi of researcher” will be used to provoke the curiosity of local communities. The awareness campaign will target the general public however special focus will be given on University students by explaining the benefits of the researcher’s profession thus playing a small but not insignificant role to the realization of the Horizon 2020 which calls out for more researchers within Europe. The events will be organized, mainly, in central places of the cities and will give the possibility of interaction between the public and the researchers throughout various activities which will be related to the problems of the local community and the solutions that researchers are able to provide, thus intriguing the public’s interest. Iit is estimated, conservatively, that ReN2014-5 messages will reach at least one million people nation-wide while more than 20.000 people will actually participate in the events each year. The impact of the events will be measured using quantitative data from questionnaires, number of participants and qualitative data such as references in media during the post-event days.

Mots clés : researchers  night, party, event, experiments, public, students, greece, athens, thessaloniki, heraklion, larissa, trikala, patras, corfu, 2014, 2015, certh, ntua, forth, upatras

Participants :
- University of Thessaly (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 27775.0 €
- Foundation for Research and Technology Hellas (Grèce) — Partner, beneficiary, Recherche, subvention : 28713.0 €
- Centre for Research and Technology Hellas (Grèce) — Coordinator, beneficiary, Recherche, subvention : 81375.0 €
- National Technical University of Athens (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 39275.0 €
- University of Patras (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 28275.0 €
Projet MagnetoVirology (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Reactive Oxygen Species (ROS)/ free radicals (FR) in cells have a very complicated role in viral infections. While some researchers point toward their usefulness in mediating viral infections, others conclude the exact opposite and claim that there are detrimental effects. To probe deeper into virus pathogenesis and improve anti-viral therapy, cellular FR - viral infection kinetics which potentially depends on virus, cell/animal model, type of reactive species, etc. needs to be investigated with high spatiotemporal resolution. However, all the traditional methods capable of detecting FR have limitations when real-time, long-duration, high resolution measurements are to be conducted within a small sample volume (inside of a cell). Recently, diamond magnetometry was proposed to study cellular FR with unparalleled sensitivity, resolution, and the possibility of real-time long-duration measurements. In this highly interdisciplinary collaborative research, I aim to establish this technique in studying cellular FR- viral infections kinetics. As a model system I will investigate the host cell FR response upon Sindbis virus (SINV) infection with high spatiotemporal resolution. FR response will be quantified via measuring T1 relaxation time of Nitrogen Vacancy centers in fluorescent nanodiamonds (FNDs). Furthermore, I intend to highlight the potential of diamond magnetometry in clinical diagnostics and drug development by demonstrating the FR detection in synovial fluid of arthritis patients (outcome of SINV infection) and detecting cells’ FR response to anti- oxidants. Upon successful completion, I will not only have elucidated the interplay of FR and SINV infections but also underscored the potential of diamond magnetometry in fundamental virology, infection biology, clinical diagnostics and pharmaceutical industry. This research strongly aligns with two work programs within Horizon 2020 focused on health (SC1-BHC) and nanotechnology- biotechnology (DT-NMBP).

Mots clés : nv defects, fluorescent nanodiamonds, magnetometry, free radicals, virus, pharmacy, medical diagnostics

Participants :
- University Medical Center Groningen (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187572.48 €
Projet NESTOR (Horizon 2020, appel à projets 2020)
Action : Staff Exchanges
Panel : Physics
Statut du projet : SIGNED

Recent advances in nanotechnology have already provided excellent platforms to reshape many areas of biocatalysis and healthcare, and yet many challenges are still being faced to produce artificial nanozymes with better catalytic efficiency. Pending achievements include having enhanced enzymatic robustness and stability while keeping the key aspects of natural enzymes such as high specificity, low toxicity and bioavailability. Consequently, there is currently a real demand for better-designed nanozymes capable to solve these challenges for the different industrial and health requirements. NESTOR project aims to develop atomically-designed nanozymes based on versatile iron-oxide-based materials, to assess their true toxicological impact and to theoretically model the microscopic mechanisms of their enzymatic-like reactions (e.g., catalase-like, peroxidase-like, etc.) and to achieve a product-oriented enzymatic activity with minimum toxicological impact, a highly relevant societal concern. The outcomes from NESTOR project are expected to provide a better control of enzymatic reactions inside living entities together with the additional properties from the new materials such as magnetic actuability, imaging or heating. These research goals are embedded in the motivation of establishing a dynamic network with NESTOR, aimed to train the next generation of materials scientists, theoretical physicists, chemists, toxicologists and medical doctors in a highly interdisciplinary research environment so they can benchmark upcoming challenges concerning the new biomedical and environmental challenges to come. This next generation of open-minded scientists with true knowledge of multidisciplinary work will be an essential actor in the complex interactions between nanotechnologies and society that lay ahead.

Mots clés : nanozymes, nanocatalysis, free radicals, dna damage, atomistic model, magnetic nanoparticles, reactive oxygen species, density functional theory

Participants :
- Universidad de Zaragoza (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 299000.0 €
- Comisión Nacional de Energía Atómica (Argentine) — Partner, organization partner, Recherche, subvention : 0.0 €
- Spanish National Research Council (Espagne) — Partner, beneficiary, Recherche, subvention : 220800.0 €
- University of Pisa (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 147200.0 €
- Consejo Nacional de Investigaciones Científicas y Técnicas (Argentine) — Partner, organization partner, Recherche, subvention : 0.0 €
- National Institute of Biology (Slovénie) — Partner, beneficiary, Recherche, subvention : 170200.0 €
Projet ITNUN (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Recent history amply demonstrates the importance of religious belief as a fundamental historical force. In studying early medieval Europe, we see how crucial it has been in the creation of our own identity, underlying our belief systems, cultural assumptions and core values, as well as our institutions. Modern history and anthropology help us pose questions of immediate concern on ethnicity and nationality, women and gender, identity and belief. I have engaged with these issues previously, with a multidisciplinary mix of history, anthropology, art history and archaeology. This research project on Italian female monasteries from 700 to 1100 is also comparative and interdisciplinary. To understand medieval society, it is essential to understand monasticism, and crucial to include Italy. I propose to bring together an integrated and broad-sweeping perspective by joining these together, and to approach the study of religious women as a laboratory for exploring the complex relationship between gender and power. Royal or aristocratic monasteries have sources detailing the names, background and activities of nuns, representative of the political and ethnic composition of Italian society. To study the evolution of nunneries makes it possible to trace changes in Italian political, social and cultural patterns, with the intermingling of family and politics. Understanding the tensions between early medieval Italian society’s male-controlled political and religious power, and the influence of noble women as queens and nuns, is essential for grasping women’s ideological and spiritual power, and for recognizing the changing configurations of medieval Italy, a key factor for comprehending some issues still at stake in Italian society today. Generally, a study of key mechanisms concerning the relationship between women, religious belief and behaviour, and politics and society can, through comprehending these in the past, illuminate key aspects of modern European societies.

Mots clés : ethnicity, social change and integration of elites, gender and power, religious belief in society, women in society

Participants :
- Ca' Foscari University of Venice (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet 3D-Xist (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Recent studies have highlighted a pivotal role for long non-coding RNAs (lncRNAs) in normal physiology and disease. As a key example, Xist lncRNA is crucial during the early development of female mammals and is involved in many diseases, e.g. progeria and cancers. To date, cellular and developmental studies have advanced our knowledge of the function of Xist, but a detailed understanding of molecular mechanism is lacking. Therefore, the overarching aim of my proposed research is to directly visualise Xist RNA/ ribonucleoprotein particles (RNPs) in cryo cells at sub-atomic resolution. To this end, I have formulated the following objectives: 1) preparing a cryo sample of mES cells expressing Xist RNA optimised for cryo electron tomography (ET); 2) visualising 3D-Xist RNPs in the mES cell; 3) generating homogenous pseudo-physiological Xist RNPs for single particle cryo-EM; 4) Solving the 3D sub-atomic resolution structure of Xist RNP; 5) Analysing a composite cryo-EM/-ET structure of the Xist RNPs in the mES cell. To achieve this aim, I will employ an interdisciplinary approach including cutting-edge cryo-structural techniques and elegant mES cell biology. My supervisor Prof Brockdorff is a leading scientist in Xist lncRNA research and the host has a state-of-the-art cryo EM facility. The University of Oxford is a world-class research centre, providing excellent transferrable skills trainings and a fantastic infrastructure for career development. The first high-resolution 3D structure of a lncRNA resulting from this innovative research will benefit not only the lncRNA research field, by providing novel molecular insight of the Xist lncRNA, but also the structural biology field, by expanding the 3D RNA structural potential. Dissemination and exploitation of this work, to be achieved by presenting in international conferences and publishing in high-impact open access journals, and communication, through public engagement, are an integral part of this proposed action.

Mots clés : long non coding rna, x chromosome silencing, xist, cryo et, cryo em, 3d structure

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet TITAN (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Recent technological advances allow to build revolutionary devices for information processing by making use of quantum mechanics. Most strikingly, quantum communication allows to transmit information with physical security guarantees and quantum algorithms solve problems that are otherwise computationally unfeasible. Having such quantum technologies in sight, it becomes imperative to investigate what can be achieved in practice but also what the ultimate limitations are. Since both questions are fundamentally concerned with processing information, it is natural to seek an information theoretic approach to find an answer. Entropy inequalities are among the most important tools in the theory of classical and quantum information processing. They have been successfully applied to bound the information flow in classical information networks and to understand the inner workings of deep neural networks. However, in the quantum case our understanding of such inequalities is currently lacking. Most importantly, the quantum information community is missing a developed theory regarding conditioning on quantum systems. This fact hinders us in fully judging the potential impact of modern quantum technologies, since one is not able to effectively determine the properties of the underlying operations. I propose to set up a conceptually novel information-theoretic framework to quantify practical advantages of quantum-based devices for network communication and machine learning, by mitigating the quantum conditioning problem. I will develop entropic inequalities that describe the change of entropy under specific operations, in particular, quantum gates and channels that can be part of an encoding or decoding circuit for quantum communication, a quantum internet or act as nodes in a quantum neural network. I will develop a framework that allows to prove such entropy inequalities, on a unified basis and employ them to better understand these important technologies of the future.

Mots clés : quantum information theory, entropy inequalities, quantum communication, quantum machine learning

Participants :
- National University of Singapore (Singapour) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Technical University of Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 262948.8 €
Projet ELMO (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Reconstructing past climate provides a powerful means to investigate how human-induced warming may be manifested in global climate. Over the last 65 million years, Earth experienced periods of extreme warmth with elevated greenhouse gas concentrations similar to projections of future climate. Of particular importance is understanding how low-latitude climate may respond to this warming due to its significance on both a local and global scale. At the local scale, low-latitude climate exerts a significant influence on the socio-economies of Earth’s most densely populated regions. Whilst at the global scale, low-latitude derived heat and moisture gets distributed poleward via a dynamic interplay of oceanic-atmospheric interactions. Thus, it is critical to fully understand a) how the low-latitudes will respond to this warming and b) the respective feedbacks on global climate. Yet characterisation of low-latitude climate during periods of warmer-than-modern climates is poorly constrained due to lack of data and limitations with the proxy methods applied to reconstruct climate variables (e.g. sea surface temperature (SST)). The past decade has seen the development of a new temperature proxy, clumped isotope thermometry, that does not suffer from the same limitations as other methods. ELMO will generate the first clumped isotope-based low-latitude records of SST and hydroclimate across the Cenozoic, including warm intervals that serve as analogues for future climate, from fossil carbonate shells (foraminifera). The novel analytical approach combining low (clumped isotopes)- and high-resolution (in-situ trace element analysis) methods will yield temperature reconstructions on a range of timescales relevant for assessing the different aspects of low-latitude and global climate evolution. ELMO will also, through comparison, provide new insights on methods of climate reconstruction applied thus far and lead to a more reliable picture of past climate in the low-latitudes.


Participants :
- University of Bergen (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214158.72 €
Projet EPILIPIN (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Reducing crop losses caused by pests and diseases is absolutely necessary to feed the increasing world population, but the use of pesticides increases the damage to the environment and contributes to climate change. As a result, international entities such as the European Union are promoting the search for alternative strategies. Experts point to “plant immunization” or priming, as the safest and most effective approach to boost the endogenous plant immune system. Unfortunately, deeper knowledge of the involved mechanisms is needed for its application in crop protection. In this context, epigenetic mechanisms and oxylipin pathways are involved in priming processes but their specific contribution as well as the relationship between these two pathways has not yet been addressed. In order to fill this gap in our knowledge we propose an ambitious but feasible project that builds on solid and exciting preliminary results. We will use the unique genetic and molecular tools available in the model plant Arabidopsis thaliana to analyse first the role of oxylipin natural compounds in different priming processes and then, study the relationship between both molecular pathways to delineate plant defence mechanisms and priming. The synergistic interaction formed by the host group, world-leading in oxylipins research, and the applicant, an expert in epigenetics, guarantees the maximization of two way transfer of knowledge, training and networking possibilities. Moreover, this action has a potentially remarkable impact and represents a key point in the applicant´s career complementing her current knowledge and expanding her skills. Taking these considerations together, the EPILIPIN project offers a unique opportunity for the development of a research that perfectly fits the EU concerns and priorities of improving crop yields minimizing the impact of agriculture on the environment by exploring the use of natural compounds (oxylipins) to trigger long term immunization (priming).

Mots clés : plant immunity, priming, epigenetics, oxylipins, arabidopsis

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €