Projet MAGNAMED (Horizon 2020, appel à projets 2016)
Action : Staff Exchanges
Panel : Physics
Statut du projet : SIGNED

MAGNAMED designs, fabricates, and assesses novel magnetic nanostructures (MNS) with unique spin configurations for innovative diagnostics and therapy techniques. An early stage detection and an effective treatment are keystones to reduce cancer mortality. Current clinical procedures fail to detect small concentration of tumoral biomarkers. Magnetic nanoparticles (MNP), like beads, have attracted much attention for their capability to improve cancer detection limits and treatment technologies. However, there are several limitations to the use of MNP. As an emerging alternative, MNS are being explored. Unlike MNP, MNS (e.g. nanodisks) present a planar shape with novel properties for diagnosis: high magnetic moment and large size, which can significantly improve the sensor sensitivity, and for therapy: due to their planar shape, alternate magnetic fields provoke a magneto-mechanical action on the cell membrane that triggers cell death. The efficiency of MNS in these two medical applications has not been investigated yet for MNS at the nanometer scale. The challenge of this project is to produce MNS with nanometer dimensions suitable for medical applications. Several lithography techniques will be used to fabricate MNS in vortex and antiferromagnetic spin configurations covering a broad size range (40 to 4000 nm). After functionalization, MNS will be exploited in: (i) Diagnostics, using giant magnetoresistance (GMR) sensors for the detection of tumoral biomarkers (dermcidin and carcinoembryonic antigen), and (ii) Therapy, effectiveness of tumoral cell annihilation by the magneto-mechanical action of MNS will be evaluated in vitro assays of melanoma and colorectal cancer cells. MAGNAMED is a cross-sectoral and interdisciplinary project involving Physics, Chemistry and Medicine. Findings will have a medium-term impact on the European strategy for early stage detection of cancer and a long-term impact on the development of novel and groundbreaking therapeutics techniques.

Mots clés : nanomagnetism, magnetic nanostructures, biomedical application, nanotechnology, vortex state, cancer diagnostic

Participants :
- Comisión Nacional de Energía Atómica (Argentine) — Partner, organization partner, Recherche, subvention : 0.0 €
- Nanovex biotechnologies sl (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 9000.0 €
- Vienna Biocenter (Autriche) — Partner, beneficiary, Recherche, subvention : 27000.0 €
- The University of Texas System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of the Basque Country (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 328500.0 €
- University of California System (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Porto (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 166500.0 €
- Ministry of Science, Technology and Innovation (Brésil) — Partner, organization partner, Recherche, subvention : 0.0 €
- Universidad Complutense de Madrid (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 45000.0 €
- Universidade Estadual de Campinas (Brésil) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Fundación Universitaria del Espinal (Colombie) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Santiago Chile (Chili) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institute for Systems Engineering and Computers (Portugal) — Partner, beneficiary, Recherche, subvention : 99000.0 €
- Spanish National Research Council (Espagne) — Partner, beneficiary, Recherche, subvention : 58500.0 €
- Img pharma biotech sociedad limitada (Espagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 85500.0 €
- Federico Santa María Technical University (Chili) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Talca (Chili) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Porto (Portugal) — Partner, beneficiary, Recherche, subvention : 27000.0 €