Projet REBONE (Horizon Europe, appel à projets 2022)
Action : Doctoral Networks
Panel : Information Science and Engineering
Statut du projet : SIGNED

The musculoskeletal system is extremely vulnerable to ageing and traumatic events, and common clinical conditions often exert a high burden on the clinical system. For patients requiring bone-substitute implants to treat critical-size bone defects, new solutions are required for meeting important unmet needs: personalised solutions for better clinical outcomes; improvements in materials to ensure higher mechanical reliability without compromising bioactive and bioresorbable properties; optimised manufacturing technologies for materials and products of high reliability and quality. REBONE is a four-year doctoral network that aims to innovatively train a new generation of researchers to develop a multidisciplinary optimisation process to provide technologies for 3D-printed personalised bone replacement implants based on bioactive ceramics. The ultimate scientific goal is to construct a platform of computational tools that will enable clinical experts to produce customized bone graft substitutes for the treatment of critical-size bone defects. This innovation will ensure that an ideal treatment solution is found on a patient-specific basis in terms of: i) mechanical and mechano-biological performance, ii) surgical implantability, and iii) manufacturing process reliability. Furthermore REBONE will develop state-of-the-art in silico models based on advanced computational methods and advanced characterisation and validation techniques to obtain personalised implants with a surgical planning visualization system in mixed reality with the following characteristics: i) tailored and reliable mechanical and physical properties; ii) best osteointegration capability; iii) targeted mechanical, physical and mechano-biological functions with patient-specific constraints taking into account the load-bearing anatomical location. Four selected clinical cases will be used as demonstrators of the optimization design and manufacturing process.

Mots clés : biomechanics, bone mechanics, additive manufacturing, bone scaffolds

Participants :
- University of Piemonte Orientale Amedeo Avogadro (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 259437.6 €
- Université de Belgrade (Serbie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 210844.8 €
- Société Ludwig Boltzmann (Autriche) — Partner, beneficiary, Recherche, subvention : 270331.2 €
- Cerhum (Belgique) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Medapp spolka akcyjna (Pologne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 226512.0 €
- Université de Salzbourg (Autriche) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 270331.2 €
- Lithoz gmbh (Autriche) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 270331.2 €
- Université Paris-Est Créteil (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Tampere (Finlande) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Znanost na cesti, zavod za promocijo znanosti, ljubljana (Slovénie) — Partner, associated partner, Autres, subvention : 0.0 €
- Allgemeine Unfallversicherungsanstalt (Autriche) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- École polytechnique de Turin (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 259437.6 €
- Université de Liège (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262620.0 €
- Eu core consulting srl (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- École polytechnique de Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 482842.2 €