Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MITONUC (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The main hypothesis of the proposed research is that, contrary to common and long-standing belief, mitochondrial genetic variation is functional and plays a key role in evolutionary adaptation. I suggest that a novel understanding of selection on mtDNA can derive from simultaneously considering sex-specific selection and genetic interactions between mtDNA and nDNA. Because males are a genetic “dead-end” for mtDNA, mtDNA mutations that are detrimental for males but beneficial for females will spread. This will generate a male-specific genetic load (“the mother’s curse”). Further, the main energy producing pathway in eukaryotes (the OXPHOS pathway) is built collectively by products of the mitochondrial and the nuclear genome. Thus, mtDNA and nDNA are potentially entangled in an intricate web of epistatic interactions that dictates organismal metabolism. The proposed research is built upon a series of interrelated parts, and will use a very amenable insect model organism and employ a range of different research methodologies. Specific aims of the proposed research is (1) to assess the effects of mito-nuclear genotype on key life history traits such as metabolic rate and test whether these effects are sex-specific in line with the “mother’s curse” and (2) to test the hypothesis that mito-nuclear interactions promotes the maintenance of polymorphism in mitochondrial genome through negative frequency dependent selection. This research will have a range of biological implications, ranging from applied medical genetics over our use of mitochondrial genetic markers in population genetics/biology to speciation and our understanding of thermal adaptation to climate change.

Mots clés : mtdna variability, mito nuclear episastasis, metabolic rate, fitness

Participants :
- Uppsala University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185857.2 €
Projet ETC-VSL (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The main objective ETC-VSL, the proposed MSCA, is the design and testing of a control algorithm for Variable Speed Limits (VSL) that approaches the behavior of an optimal controller and can, at the same time, be applied in practice to large traffic networks. When designing this controller, it has to be taken into account in general that a linear or logic-based controller for VSL, which can performs properly for one particular kind of congestion, is not going to approach an optimal behavior for other kinds of congestion. In fact, all the previously proposed algorithms for VSL performs suboptimally or are difficult to implement in practice. Therefore, this proposal suggests the use of two control levels: In the upper level, a scheduling controller detects online the main kinds of congestion (recurrent congestions, shock waves and unexpected capacity reductions) and, in the lower level, a practically implementable controller for each kind of congestion is used. In order to achieve this objective, the proposal considers the following steps: Step 1: The design or selection of a triggering rule that estimates what kind of congestion the system is showing (if any). Step 2: The design or selection of a controller that works for each kind of congestion. Step 3: The collection of a loop detector data set from the SE-30 ring-road in Spain. Step 4: The testing and evaluation of the proposed algorithm in two freeways (SE-30 in Spain and A12 in The Netherlands) that show the main kinds of congestion allowing an objective evaluation of the designed VSL control algorithm and a comparison with previously proposed techniques. Step 5: The analysis of the economic and social improvements that can be obtained by the implementation of VSL applying a Benefit-Cost Analysis. Step 6: Dissemination of results and communication towards the technical and non-technical community in order to show the potential performance that can be achieved using the newly developed VSL control strategy.

Mots clés : variable speed limits, freeway traffic control

Participants :
- Delft University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet ERROR (Horizon 2020, appel à projets 2015)
Action : Staff Exchanges
Panel : Life Sciences
Statut du projet : CLOSED

The main objective of ERROR is to develop a new software tool, which will offer to the clinician the possibility to assess alternative imaging and therapeutic protocols, in real time, in silico, in order to minimize patient dose, while maintaining image quality of therapeutic effect. This tool will be designed, implemented and evaluated with specific focus on pediatric patients, since this is a rather sensitive target group, where dose considerations are high and no standard protocols and solutions exist. The project will exploit the new generation of computational anthropomorphic phantoms, in combination with well validated Monte Carlo simulations and Machine Learning Tools. In this way, it is envisaged that advanced, yet mature technologies will be integrated, to provide a novel tool, which can lead to a final product. The ERROR project brings together a multidisciplinary consortium of specialists in different areas of medical physics, biomedical engineering, physicians and computer engineers, who will join forces in order to design, implement and clinically assess a novel software tools, which initial focus in the optimization of diagnostic and therapeutic protocols for pediatric exams. Two new SMEs will provide their expertise, as well as investigate the ways to exploit project outcome. A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of pediatric clinical applications, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society.

Mots clés : brachytherapy, computational phantoms, dosimetry, gate, monte carlo simulations, pediatric applications, personalized medicine, radionuclide therapy, radiotherapy

Participants :
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 45000.0 €
- Guy's and St Thomas' NHS Foundation Trust (Royaume-Uni) — Partner, beneficiary, Recherche, subvention : 27000.0 €
- Bioemission technology solutions ike (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 90000.0 €
- University of Patras (Grèce) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 103500.0 €
- Université de Brest (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 76500.0 €
- Libra mli ltd (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 90000.0 €
Projet FAWORIT 2016-2017 (Horizon 2020, appel à projets 2016)
Action : European Researchers' Night
Statut du projet : CLOSED

The main objective of our FAWORIT proposal is twofold: 1) to show the public how researchers with their innovative solutions affect our daily lives; 2) to encourage the youth – with a special focus on girls – to embark on scientific careers by involving young innovators in our programmes. Our main target group is students between the age of 8-20, but we aim to address all age groups with attractive programmes. Some novelties of our project: offering challenge-oriented activities – each of our 18 venues will present their innovative solutions related to interdisciplinary societal challenges; focussing on the concept of Responsible Research and Innovation - the audience will be informed about key elements of RRI, thus creating better understanding and fostering future involvement; launching “Science in the City” – a flash mob like activity, involving the public in spectacular experiments. We will apply an integrated approach in our project in which interdisciplinary challenges, innovative solutions, (young) researchers, their work and hobbies will be presented in an interactive, educating and entertaining way. The target audience can thus discover that being a researcher is cool and creative; researchers, but and young innovators are amongst us. Our objective is to have around 30000 visitors at the events, but a multiple of that number (around 500000) will see, hear or read about the Night. We intend to raise awareness of the European engagement in R&I; in the European Corners and at each venue related programmes of the European Union (FP7, H2020, especially MSCA) will be visible. The structure of the consortium: an innovative SME, a state-owned applied research institution, a highly innovative large company, a scientific association with a broad network of local member institutions all over Hungary and an independent think tank established by economists and sociologists together with numerous contributing partners of all kinds will ensure the success of the project.

Mots clés : public recognition, young innovators, responsible research and innovation, societal challenges, women in science, edutainment, innovative products, services, attractiveness of researchers  career, media

Participants :
- Bay Zoltán Foundation for Applied Research (Hongrie) — Partner, beneficiary, Recherche, subvention : 59625.0 €
- HÉTFA Research Institute (Hongrie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 48825.0 €
- Tudományos Ismeretterjesztő Társulat (Hongrie) — Partner, beneficiary, Autres, subvention : 17300.0 €
- Regional Center for Information and Scientific Development (Hongrie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 81925.0 €
Projet FAWORIT 2018-2019 (Horizon 2020, appel à projets 2018)
Action : European Researchers' Night
Statut du projet : CLOSED

The main objective of our proposal is to present researchers from several aspects in order to get them closer to the general public and to encourage the youth – with a special focus on girls – to embark on scientific careers. We will apply a mission-oriented, impact-focused approach in our project in which interdisciplinary challenges, innovative solutions, (young) researchers, their work and hobbies will be presented in an interactive, educating and entertaining way to stimulate the interest of citizens towards R&I and to bring it closer to their expectations and concerns. A special attention will be given to the role of R&I in discovery, preservation and demonstration of cultural heritage; the bridges between STEM and cultural heritage will be demonstrated. As the consortium and the cooperating partners represent well the relationship of the knowledge triangle, the involvement of many different actors across various disciplines and sectors will achieve a high impact and make researchers and innovators' work familiar to various age groups. Our main target group is students of age 6-26, but we aim to address all age groups – siblings, parents & grandparents – with attractive programmes. The target audience can thus discover that being a researcher is cool and creative and not only researchers, but young innovators are also amongst us. Our objective is to have at least 30000 visitors on our 24 venues on the two-day event, but a multiple of that number (at least 1000000) will see, hear or read about the NIGHT. Our venues cover the whole country. We expect at least doubling them by organisations joining the NIGHT – the most important science communication event in Hungary – as the result of the awareness raising campaign. We intend to raise awareness of the European engagement in R&I through the participation of H2020 projects with a special focus on MSCAs. In the European Corners and at each venue related programmes of the European Union will be visible.

Mots clés : stem, steam, responsible research and innovation, cultural heritage, public recognition, researchers  carreer, mission oriented and impact focused approach, societal chall, women in science, edutainment

Participants :
- Nok a tudomanyban egyesulet (Hongrie) — Partner, beneficiary, Recherche, subvention : 49625.0 €
- Bay Zoltán Foundation for Applied Research (Hongrie) — Partner, beneficiary, Recherche, subvention : 52500.0 €
- HÉTFA Research Institute (Hongrie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 39000.0 €
- Tudományos Ismeretterjesztő Társulat (Hongrie) — Partner, beneficiary, Autres, subvention : 17500.0 €
- Regional Center for Information and Scientific Development (Hongrie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 79750.0 €
Projet FAWORIT 2020 (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

The main objective of our proposal is to present researchers from several aspects in order to get them closer to the general public and to encourage the youth, especially girls, to embark on scientific careers. We will apply a mission-oriented, impact-focused approach in our project in which interdisciplinary challenges, innovative solutions; researchers, their work and hobbies will be presented in an interactive, educating and entertaining way to stimulate the interest of citizens towards R&I, and to bring it closer to their expectations and concerns. A special attention will be given to the role of R&I in discovery and supporting European growth and prosperity, societal relevance of EU research policy and stakeholder involvement from society. Pre- & follow-up events will be organised, dissemination activities will maintain after the project lifetime in order to sustain the interest raised. The involvement of many different actors across various disciplines and sectors will achieve a high impact and make researchers’ work familiar to various age groups. Our main target group is students of age 6-26, but we aim to address all age groups with attractive programmes. The target audience can thus discover that both scholars and young innovators are amongst us and being a researcher is cool and creative. Our ambitious but realistic objective is to have at least 30000 visitors on our venues on the two-day event, but a multiple of that number (at least 1000000) will see, hear or read about the NIGHT. Our venues cover the whole country. As the result of the awareness raising campaign several organisations will join the NIGHT, the most important science communication event in Hungary, thus contributing to the multiplication of the number of visitors. We intend to raise awareness of the European engagement in R&I through the participation of H2020 projects with a special focus on MSCAs. In the European Corners and at each venue related programmes of the EU will be visible.

Mots clés : citizen involvement, esr and and young innovators, societal relevance, women in science, edutainment, innovative products, services, attractiveness of researchers  career, social media

Participants :
- Óbuda University (Hongrie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 26500.0 €
- Regional Center for Information and Scientific Development (Hongrie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 47950.0 €
- Nok a tudomanyban egyesulet (Hongrie) — Partner, beneficiary, Recherche, subvention : 47750.0 €
- Tudományos Ismeretterjesztő Társulat (Hongrie) — Partner, beneficiary, Autres, subvention : 12000.0 €
- HÉTFA Research Institute (Hongrie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 24650.0 €
Projet NANOCARB (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The main objective of the NANOCARB project is to prepare the experienced researcher (ER) for an independent career through the implementation of a frontier research project and a training programme covering all aspects that are required for running a research group. The NANOCARB project has the scientific objective to build up an original method for the development of an innovative class of carbohydrate receptors using dynamic combinatorial chemistry (DCC) on the surface of a gold nanoparticle. Molecular receptors capable of carbohydrate recognition have a great potential in diagnostics and therapeutics. However, this prospective is still remote as it has turned out that designing synthetic receptor molecules able to selectively bind carbohydrates in water is very difficult. The distinguishing feature of this project is that the recognition site for the carbohydrate target is spontaneously formed, driven by the carbohydrate target itself. The self-selected recognition units will then be immobilized covalently on the gold nanoparticle, yielding a multivalent nanosystem able to recognize its target also in vivo. The project is on the interphase between chemistry, biology and nanotechnology providing an excellent opportunity for the experienced researcher (ER) to develop skills in these areas. Training excellence within the context of becoming independent researcher will involve manuscript and research proposal preparation, public engagement, IPR issues, networking, and conference organization. The project also benefits from external input and a secondment from other groups (Prof. Lay, University of Milan and Prof. Lombardi, University of Piemonte Orientale) in order to fill lacunes not available at the host institution. The combined package of scientific and training objectives will make the NANOCARB project an excellent platform for kick-starting the independent career of the ER and generating a strong visibility to the host institution.

Mots clés : carbohydrate recognition, dynamic combinatorial chemistry, monolayer imprinting, multivalency, nanosystem, self selection

Participants :
- University of Padua (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet SEPhIM (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The main objective of the SEPhIM research action is the development and exploitation of strong electron-photon interactions with photonic-chip-based high-Q microresonators and photo-induced near-field electron microscopy (PINEM). This will be achieved using the ultra-high quality factor of integrated microresonators to enhance the coupling strength between free electrons and cavity photons in an ultrafast transmission electron microscope (UTEM). This project will bridge and separately advance the fields of integrated photonics, ultrafast electron microscopy, and quantum optics. By performing UTEM-PINEM, a multidimensional imaging and spectroscopy of the microresonators are available. The enhanced electron-photon interaction, mediated by the high Q-factor of the microresonators, will lead to a strong phase modulation of free electrons, a wide spectral broadening of the electron energy, and the measurement of cavity-photon lifetime. Moreover, using temporal dissipative solitons formed in the microresonators, time-gated electron-soliton interactions will also be investigated. Due to the strong spatiotemporal confinement of the soliton pulse, the electron-photon coupling will be further enhanced. Attosecond electron pulses in UTEM will enable time-domain electron microscopy of the soliton waveforms, while the concomitant generation of optical frequency combs will provide spectrally-resolved characterization of the electron-soliton interaction. Furthermore, strong coupling between free electrons and cavity photons will enable quantum state synthesis and entanglement generation. As a proof-of-concept demonstration, we intend to perform all-optical non-demolition detection of free electrons. The electron-photon interaction will be used to herald and register transmitted electrons, thus suppressing shot-noise in the electron beam. This will improve the signal-to-noise ratio and reduce radiation damage in electron imaging and spectroscopy techniques.

Mots clés : ultrafast electron microscopy, photo induced near field electron microscopy, high q microresonators, solitons

Participants :
- Board of the Swiss Federal Institutes of Technology (Suisse) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191149.44 €
Projet ESSENTIALS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The main objective of the project is to provide insights into the study and interpretation of processes that contribute to the promotion of networks of Social and Solidarity Economy (SSE). The research also aims at identifying models that can lead to social inclusion and local development. Moreover, the project ESSENTIALS will focus on a specific experience: Social Incubators, in an attempt to encourage socio-economic development of a specific area or of a whole country, regarding processes of social innovation and transfer of knowledge. In particular, the specific objectives, of the project are: OB. 1. Map the incubators and compare the characteristics in Latin America and EU, understanding if there is a relationship between gender and organisational characteristics of an incubator. OB. 2. Identify the factors that contribute to the creation of incubators and the impacts of incubators, including the elements that ensure gender equality, through a comparative study. OB. 3. Analyse the European context considering the strengths and weaknesses identified and thus develop a pilot study at University of Calabria, including the gender perspective. The research carried out in Latin America will be compared (quantitatively and qualitatively) with European incubation activities. The relevance of this research is linked to understanding how to favour models capable of building a more Social and solidarity Europe, and closer to citizens. Thus, this project represents an important innovation for two reasons: (i) the study contributes to the debate on the role of social incubators and the most effective model to adopt, and brings new knowledge in Europe on the topic of social incubators oriented to the territory, a topic not widely investigated in Europe; (ii) it suggests a pratical solution for the implementation of social incubators in Europe, through the pilot study of creating a social incubator, that will provide feedback for new theoretical and cognitive elements.

Mots clés : social and solidarity economy, social incubator, social innovation, local development, action research, territorial development, social enterprises, comparative local governance and policies

Participants :
- National University of Quilmes (Argentine) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- University of Calabria (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 229767.36 €