Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet DiVA (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : TERMINATED

The Large Hadron Collider (LHC) probes interactions among particles with unprecedented precision. The determination of the Higgs boson properties is a central pillar of the LHC physics program and of the current LHC run.  This demands for accurate theoretical predictions, which usually hinge on Monte Carlo event generators. State-of-the-art predictions are given by next-to-leading-order (NLO) calculations in QCD matched to leading-logarithmic (LL) parton shower (PS). Next-to-NLO (NNLO) matching, necessary to advance the accuracy of theoretical predictions, is limited to specific processes, like the hadro-production of heavy systems in the final state.  Vector Boson Fusion (VBF) is the preferred channel for the determination of the Higgs to muon couplings and for Higgs to invisible searches. This project's aim is to pioneer NNLO matching techniques for processes characterised by the t-channel exchange of a colourless boson, such as VBF and Vector Boson Scattering (VBS), and to develop the first NNLO+PS generator for Higgs boson production in VBF.  Given the close relationship between higher-order corrections in VBF, VBS, and Deep Inelastic Scattering (DIS), the initial focus will be the formulation of a NNLO+PS matching scheme for DIS. This matching will preserve the logarithmic accuracy of both the new next-to LL (NLL) showers, and the standard LL ones. Additionally, to achieve this task, novel resummed predictions for DIS will be produced. Reaching NNLO+NLL accuracy within a comprehensive PS simulation is a groundbreaking endeavour.  These outcomes will be vital for precise studies of the Higgs sector in the current and future LHC runs, and for high-precision investigations at future DIS-type facilities like the Electron-Ion Collider. Furthermore, this project will lay the foundations for a more widely applicable NNLO+PS matching approach with superior logarithmic accuracy, which can be extended to a broader range of collider processes involving QCD jets.

Mots clés : perturbative qcd, higher order computations, parton showers, nnlo, collider phenomenology, lhc, eic

Participants :
- Université de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 297164.16 €
- Université de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet EXIT PLAN (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

In today’s fast-paced world, the need for innovative solutions leads to a preference for applied sciences over fundamental research, to the detriment of possible ground-breaking discoveries and revolutions in the future. This is the case of plant extracellular nanovesicles (PEVs), small vesicles secreted by plants which were first discovered in plant defence against pathogens, but that were soon co-opted by the biomedical research as promising nutraceuticals and drug delivery tools. To date, the majority of scientific literature on PEVs focuses on their possible therapeutic uses. Nonetheless, little is known about their biogenesis, secretion mechanism, and function in the plant kingdom, especially in physiological processes such as cell growth. This enormous gap in knowledge not only hinders their exploitation in plant biotechnology and agronomy, but also limits their safety in medical applications. EXIT PLAN will fill in this gap addressing three main research objectives (ROs), through three research work packages (WPs). First, the project will assess the nature of PEVs secreted during the apical growth of plant cells (RO1, WP2), and in particular pollen and root hairs. For this purpose, biomedical techniques for the characterisation of human nanovesicles will be readapted to isolate and characterise PEVs, during the secondment at Nottingham Trent University. Then, RO1 will be furtherly investigated at the University of Zurich, using plant transformation, advanced microscopy, and omics analyses to identify different PEVs populations. The same approach will be adopted to unveil how PEVs are externalised from the cell wall (RO2, WP3). Finally, the techniques learned during the outgoing phase will be implemented with a molecular biology approach at the University of Bologna, during the return phase, to understand the role of PEVs in cellular communication during cell growth (RO3, WP4), identifying PEVs targets and understanding the effects of PEV-based signalling.

Mots clés : extracellular vesicles, apical growth, plant cell wall, intercellular communication, lrxs

Participants :
- Université de Bologne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 412700.52 €
- Université de Nottingham Trent (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Zurich (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet INFLAMAM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Alzheimer’s disease (AD) is an irreversible neurodegenerative condition affecting 50 million people worldwide. Despite intense research, the pathological mechanisms of AD are still unclear. Many genetic loci robustly associated with AD code for proteins that are preferentially or exclusively expressed in microglia, supporting a causal role of microglia as key players in disease initiation and progression. Microglia are brain-resident immune cells that, upon activation, reorganize their cellular membranes by coordinating a network of lipid pathways at unique subcellular regions localized in the endoplasmic reticulum, called MAMs (Mitochondria-associated ER membranes), the membrane contact site between ER and mitochondria. Hyperactivation of MAM is shown to be associated with AD pathogenesis, however, the impact of MAM alteration on microglia biology is unexplored. The main objective of INFLAMAM is to determine the mechanism by which MAM regulates microglia activation, and the impact of defects in MAM and lipid homeostasis in the context of AD. To that aim, we propose to combine cutting-edge lipidomics and proteomics approaches with pharmacological and genetic MAM intervention strategies to identify relevant molecular drivers that enable the crosstalk between lipid metabolism and immune signaling at MAM in microglia. By proving the role of MAM as an immunometabolic hub for inflammation and a driver of AD pathogenesis, we believe this innovative project has the potential to pinpoint relevant lipid pathways as new targets for pharmacological intervention to alleviate the symptomatology related to microglia in AD.

Mots clés : mitochondria associated er membranes, lipid metabolism, microglia, inflammation, alzheimer s disease

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
- Université de Fribourg (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet HOLYFLOW (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : SIGNED

The geometric objects that can be perceived by our senses are curves and surfaces. Submanifolds provide a natural generalization for higher dimensions of these objects. The focus of this project is on totally geodesic submanifolds and isoparametric hypersurfaces, intriguing classes of submanifolds with connections to various mathematical areas, often studied using differential geometric, algebraic, or topological methods.  The aim of this project is to investigate the interplay of totally geodesic submanifolds with Riemannian holonomy and isoparametric hypersurfaces with certain geometric flows, with the ultimate goal of obtaining results of both intrinsic and extrinsic nature. Specifically, we intend to complete the classifications of totally geodesic submanifolds in symmetric spaces and of homogeneous hypersurfaces in exceptional symmetric spaces. We will also use certain classes of isoparametric hypersurfaces in combination with maximum principles to try to prove an Alexandrov-type theorem in the complex hyperbolic space and long-time existence for the hypersymplectic flow.  To develop this project, the Experienced Researcher will join the Geometric Analysis team at ULB in Brussels, under the supervision of one of its main researchers, Joel Fine. The host group has extensive experience in the study of manifolds with special holonomy and geometric flows, using techniques from PDE theory. The training strategy of this project involves assimilating these techniques. Moreover, the ER has experience in the classical theory of submanifolds in symmetric spaces, as evidenced by his contributions to the field. The combination of both backgrounds is essential for developing this proposal.  Finally, this MSCA fellowship will enhance the convergence of distinct research fields and collaborative networks, generate synergy with the research performed by the Supervisor, diversify the fellow’s mathematical knowledge, and establish him as an independent researcher.

Mots clés : isoparametric hypersurfaces, totally geodesic, homogeneous spaces, symmetric spaces, cohomogeneity one, holonomy, hypersymplectic, geometric flows, constant mean curvature

Participants :
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet ECHAUTISM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

ECHAUTISM, carried out jointly between CARE at Boston University and ACTE at the Université libre de Bruxelles, aims at investigating the nature of echolalia in autism from a linguistic, behavioural and neural perspective. Echolalia, the exact repetition of the words of others, is a salient clinical feature of autism that is defined by some as a senseless stereotyped and repetitive behaviour and by others as a communicative unusual form of language. ECHAUTISM will ask three specific questions in regard to the nature of echolalia in autism. First, it will investigate whether autistic echolalia should be considered as a symptomatologic manifestation of repetitive behaviours or a late onset form of typical speech imitation. This will be answered by qualitatively and quantitatively describing and comparing the repetitive and the spontaneous speech production of a group of echolalic autistic preschoolers, a group of echolalic autistic adolescents and a group of 2- to 3-year-old typically developing children on measures of linguistic complexity, communicative behaviour, and brain activity. Second, it will ask whether echolalia can function, for some autistic children at least, as a gestalt strategy to language acquisition. This will be answered by evaluating the language abilities of the group of autistic preschoolers one year later to assess whether their speech became more functional and productive. Finally, it will provide an update on the perception of and actions taken towards echolalia by autistic children’s primary caregivers. This will be answered by disseminating a survey among speech-language pathologists specialised in autism and parents of autistic children. ECHAUTISM will have a significant impact on the researcher's career by internationalising her research profile and training her in cutting-edge neuroimaging techniques. Its outcomes should be relevant for both scientific and clinical perspectives of autism.

Mots clés : autism spectrum disorder, echolalia, language acquisition, fnirs

Participants :
- Boston University (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 266684.16 €
Projet PriMCo (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

While attention on privileged mobility has predominantly centered on retirees, tourists, lifestyle migrants or obligatory short-term expatriates, scant consideration has been given to the dynamics of medium- or long-term settlement linked to transnational conjugality. Yet, privileged migrants often marry citizens of the host country, and these migratory and matrimony flows are gendered. Whereas European women tend to form conjugal relationships with African men, European men are predominantly involved with South-East Asian women. How can we comprehend these cartographies of desire? Particularly in Islamic countries, what motivates European men and women to establish permanent residences and families in settings where gender norms significantly differ from their countries of origin? How do they adapt to these normative regimes and in what ways do they challenge power relations within the conjugal experience and their host societies? Furthermore, how do they navigate their positions between the two countries to which they belong? To tackle these issues, the project “Privileged Mobility and Transnational Conjugality in Islamic countries: reconsidering global power relations from gender perspective in Southeast Asia and West Africa” (PriMCo) relies on a comparative case study encompassing the Mauritanian and Malaysian capitals based on anthropological (ethnography), sociological (semi-structured, biographical interviews, focus group) and visual methods (filmmaking). This research critically examines the notion of white privilege, shedding a light on the renegotiation of race, gender, and class relations within intimate and global contexts. In addition, at a societal level, by documenting the experiences of individuals from diverse national, racial, and religious backgrounds who engage in relationships, PriMCo fights against racist prejudice and raises awareness of the existence, diversity and richness of transnational families.

Mots clés : transnational conjugality privileged migration mobility gender power relations islamic countries globalization ethnography

Participants :
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet Emotiv4climate (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Providing large-scale sustainability education programs, in particular regarding climate issues, is critical to quickly implement the profound socio-ecological transformations expected by the mid-21st century. Although climate awareness is growing, current education policies -which mainly warn the risks of climate change, therefore focusing on negative contents- struggle to reach their objectives, as misinformation and poor knowledge assimilation persist. Yet, recent advances in neurosciences suggest that while negative emotion strengthen the memory of the emotional element, it disrupts associative memory, which is essential for the development of complex multivariate representations. Leveraging cutting-edge neurophysiological techniques (magnetoencephalography, electroencephalography), Emotiv4climate hypothesizes that positive emotions will enhance associative memory due to the selective integration of the newly learned information within hippocampus-dependent networks that promote their binding. And that positive memories will benefit more from sleep-dependent consolidation processes than negative ones, favouring their integration within pre-existing knowledge. Using ecology-themed material and questionnaires, Emotiv4climate will elucidate the differential impact of emotions (positive vs negative) on the behavioural and functional brain connectivity processes associated with learning and memory processes with an applied dimension to climate-related educational issues. Our understanding will benefit from a developmental approach comparing young adults and school-aged children with different maturational levels in terms of sleep-dependent memory consolidation processes. Emotiv4climate will hence not only uncover the cognitive and neurophysiological mechanisms through which emotions impact learning and memory consolidation throughout development but also help designing optimized communication and education strategies likely to catalyse sustainable behaviour.

Mots clés : declarative learning, memory consolidation, emotions, sleep, children, cognitive development, magnetoencephalography, brain connectivity, theta activity, salience tag

Participants :
- Hospital for Sick Children (Canada) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université libre de Bruxelles (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200400.0 €
Projet ScholaResc (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

ScholaResc aims at examining the academic (re)insertion of exiled scholars from the Global South and to detect what innovations they bring to their host societies. This interdisciplinary project will develop an original methodology combining network, bibliometric and biographical analysis designed to allow systematic mapping of the academic exchanges between exiled scholars and their peers in the destination countries. This toolkit will be applied to carry out an in-depth socio-historical study of the exile of Brazilian scholars in France after the military coup of 1964. This original investigation of an understudied case of academic rescue with long-lasting intellectual legacies contributes to the research agenda on the international circulation of knowledge and global intellectual history, as well as to the fields of Latin-American, exile, and migration network studies. Moreover, it sheds light on contemporary trends and challenges arising from the inclusion of exiled scholars into host societies. This topic is particularly timely and relevant because of the significant growth of threats to academic freedom in the past decade. The methodology developed for this research will be openly shared with the civil society organizations and policymakers currently engaged in helping academics at risk. Intersectoral dialogues with these organizations will lead to the adaptation of the tools to the study of current cases of scholar integration and to the dissemination of the findings of the research, thus contributing to promote a more inclusive and diverse science and society. ScholaResc will be carried at the interdisciplinary Laboratoire d’Économie et de Sociologie du Travail (LEST) affiliated to the Centre National de la Recherche Scientifique (CNRS) and Aix-Marseille University (AMU).

Mots clés : scholar rescue exile social network analysis bibliometric analysis biographical bifurcations

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
- Université libre de Bruxelles (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ForestPulse (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Forests play a crucial climate-regulating role, acting as a resilient interface between the soil and the atmosphere, fostering biodiversity, natural resources or carbon capture. However, climate change, especially severe droughts, may push them beyond their limits. Traditional eco-hydrological methods provide valuable insights on tree-water interactions, but observational gaps hinder a full understanding of how trees mitigate water stress and source water. What could be the advantages of geophysical monitoring? With recent advancements in geoelectrical and Fibre Optic Sensing (FOS) technologies, geophysics can monitor water storage and fluxes within and around trees with unprecedented resolution.  In ForestPulse, I will address methodological barriers to unlock the full potential of geophysical monitoring in forest ecosystems. Advanced monitoring systems at the Bambësch Forest, Luxembourg, will track seasonal and diurnal water dynamics wihtin the soil-tree-atmosphere continuum and enhance our understanding of tree responses to drought. Long-term geoelectrical monitoring, using a distributed network of open-source resistivity meters, will image soil and tree water dynamics on beech stands. Pilot FOS experiments will investigate finer-scale water uptake and flow patterns.  Hosted in a multidisciplinary team of eco-hydrologists at the Luxembourg Institute of Science and Technology, I will foster interdisciplinary collaboration. Secondments at the Université libre de Bruxelles and Royal Observatory of Belgium will support cutting-edge methodological advancements. ForestPulse will enhance my career by strategically focusing my geophysical expertise on eco-hydrological challenges. Integrating open-source geophysical tools into forest monitoring and improving the observability of tree-water dynamics will contribute to more sustainable forest management practices, help to fight climate change, and pave the way for future research projects on eco-hydrogeophysics.


Participants :
- Observatoire royal de belgique (Belgique) — Partner, associated partner, Recherche, subvention : 0.0 €
- Luxembourg Institute of science and technology (Luxembourg) — Coordinator, beneficiary, Recherche, subvention : 216240.0 €
- Université libre de Bruxelles (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €