Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Mito-MechaMet (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Mitochondria are double-membrane organelles that sustain the bioenergetic metabolism of cells by producing ATP at the level of the cristae, convoluted folds of the inner membrane. ATP production efficiency and mitochondrial morphology, including cristae architecture, are tightly linked. Consequently, by being coupled to mitochondrial function, the reshaping of mitochondria across spatial scales regulates the cellular bioenergetic and metabolic states. Mechanical stimuli have recently been shown to modulate cellular metabolism, thus impacting physiological (e.g. cell migration, proliferation, death) and pathological (e.g. cancer progression) processes. Mechanical forces are able to reshape the global morphology of mitochondria. However, cristae remodelling upon mechanical stimuli has not yet been unravelled, and it remains unknown whether mitochondria are the key regulators of bioenergetic mechanometabolism. In Mito-MechaMet project I aim to unveil how force-induced changes in mitochondrial cristae architecture (Aim1) modulate cellular bioenergetic metabolism (Aim2) via nanoscale reorganization of proteins regulating mitochondrial shape (Aim3). These ambitious objectives will be achieved by bringing together my experience and skills on mitochondria imaging, the expertise of the host laboratory (G Giannone lab, CNRS, Bordeaux) on mechanobiology and super-resolution, and the know-how of collaborators regarding mitochondrial metabolism (BioDynaMit lab, CNRS, Bordeaux). Mito-MechaMet results will impact several fields ranging from biophysics and biomechanics to cellular biology, especially cancer biology, where mechanical cues in the tumor microenvironment critically regulate mitochondria dynamics and cancer progression. Altogether, the Mito-MechaMet project represents a uniquely tailored opportunity for me to master the necessary skills, experience and independence to pursue my long-term aspiration of leading an independent lab investigating mitochondrial biomechanics.

Mots clés : mechanobiology mitochondria bioenergetics mitochondrial morphology super resolution cristae stretching device nanoscale live biomechanics imaging

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet AWOKAZ (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Space exploration is driven by work and values. AWOKAZ investigates the role of work and values in creating, maintaining and disrupting social relations in and around the observatories and laboratories of the Fesenkov Institute of Astrophysics (FAI) in Kazakhstan. The research aim of AWOKAZ is to advance understanding of how astronomers, herders and tourist guides value and construct their lives in relation to space and space research infrastructures. "Astrovalues" in this research are the multifaceted economic, imaginative and moral forces that motivate actors' everyday practices of engagement with cosmic events and processes. These diverse forms of engagement include, but are not limited to, scientific passions of abstraction, touristic forms of commodification and consumption of the night sky, and various relations to the stars as guides or mythological figures. The project will provide a robust analysis of how the work of astronomers, guides and shepherds is mediated by the economic forces of the free market as well as the moral socio-cultural values of relating to cosmic processes. AWOKAZ will focus on the histories, contemporary practices and biographical trajectories of the astronomers, tour guides and shepherds who live and work in or around the astrophysical observatories of the Fesenkov Astrophysical Institute (FAI).

Mots clés : social studies of outer space, central asian studies, infrastructure studies, anthropology of value, infrastructure studies

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet CO2RedFePP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

As contemporary society faces increasingly difficult challenges arising from climate change, devising means for the reduction of anthropogenic greenhouse emissions has become a focal point of research. The reduction of CO2 to profitable products such as CO is a promising means to that end. Unfortunately, the highly inert CO2 makes this endeavour practically impossible without the use of sophisticated catalytic procedures. Iron-polypyridine (FePP) complexes, were found to be promising candidates, triggering a race to find the optimal catalytic system. Computational studies (including by me) have provided essential insights to groups in this race but have so far been solely used to rationalise experimental results. By combining my in-depth knowledge on the computational investigation of transition metal complexes with the Rulíšek group’s expertise in the handling large chemical sampling spaces and the description of solvation effects and the IOCB’s vast computational resources, we propose a proactive computational investigation into the space of potential FePP catalysts. Therein, we will use a robust quantum chemical protocol, tested in the investigation of FePP properties, in combination with a stepwise elimination procedure to evaluate the expectable suitability of a large sampling space of FePP catalysts w.r.t. the reduction of CO2 to CO. We will further use these data to elucidate the relevance of the chemical features of the FePP class for this reduction reaction. We expect that our data will considerably advance the race for the most active, cost-efficient and selective catalyst for the reduction of CO2 and, therefore, accelerate the development of economical applications the significantly reduce human CO2 emissions. Personally, this project will enhance my scientific knowledge as well as my presentation and tutoring skills, thereby boosting my development as an independent researcher.

Mots clés : co2 reduction, artificial photosynthesis, climate change

Participants :
- Institute of Organic Chemistry and Biochemistry (Rép. Tchèque) — Coordinator, beneficiary, Recherche, subvention : 191918.16 €
- Université de Ferrare (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet OPS-CLC (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Interaction between light waves and chiral matter is a fundamental topic in optics and material sciences. When the matter is chiral, light can exert linear and angular momentum, optical torque, which has a differentiated sense depending on the handedness of the material and the helicity of the light. In this project, we propose to exploit the intrinsic chirality of cholesteric liquid crystals droplets on a microfluidic chamber to generate a differentiated rotation on different enantiomers of cholesteric liquid crystal. It has been shown numerically that rotating disks on a fluid produce a sorting effect, isolating the disks with different rotation senses. In this project, we propose to exploit the chirality in cholesteric liquid crystals to generate contactless enantioseparation of droplets with plane wavefront linearly polarised light, ensuring a robust and scalable enantioseparation technique. The project contemplates producing optical enantioseparation of polydisperse cholesteric liquid crystal droplets immersed in a microfluidic chamber. The project focuses on developing multidisciplinary aspects of light and matter interaction, specifically when there is a handedness, both in light and matter and is expected to generate impact and enhance new concepts in multiple fields ranging from applied mathematics to chemistry. The Researcher of the proposed project is Gregorio González, PhD candidate of the University of Chile, Chile, with experience in nonlinear dynamics induced by light interaction on liquid crystal layers. The Supervisor will be Professor Etienne Brasselet in the Singular Optics group, at the Host Institution, the University of Bordeaux, France.

Mots clés : chirality, cholesteric liquid crystal, optical sorting, enantiomer

Participants :
- Université de Bordeaux (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209400.88 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet ReLay (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Today’s technology for the biocatalytic production of base chemicals is fossil-fuel based. Moving away from non-renewable and carbon-based energy feedstocks towards renewable hydrogen is a key challenge for current chemical processes. However, biocatalysis has yet to see H2 implemented as a energy source, simply because such H2-consuming reactions are sensitive to O2, whereas many enzymatic reactions driving product formation require O2 as a cosubstrate. H2-driven biocatalysis is not realized today on a large scale because of this need for both O2-sensitive and O2-dependent reactions to operate in tandem. The goal of this Marie Skłodowska-Curie Postdoctoral Fellowship project is to deliver the theoretical framework and experimental validation for novel biohybrid catalytic microdisks capable of carrying out seemingly incompatible tandem reactions by controlling the spatial separation of reaction layers (ReLay). Driven by both theory and simulation, the optimal conditions will be found to create both anaerobic and aerobic domains allowing O2-sensitive and O2-dependent reactions to take place within a single particle. This will be accomplished by, first, building a reaction-diffusion model and simulation toolbox to establish the theoretical framework of spatially separated reaction layers in these catalytic micodisks. Second, the parameter space will be explored using the model and simulations to find the best performing components and conditions. Finally, these predictions will be validated with an experimental case-study, comparing the expected output from the model with the actual reaction rates and concentrations gradients measured experimentally for an O2-dependent oxyfunctionalization driven by H2 within the catalytic microdisks. These actions will create a universal platform for H2-driven biocatalysis, which can be implemented directly in current bioreactors.

Mots clés : reaction diffusion modeling, biocatalysis, hydrogenase enzymes

Participants :
- Université technique de Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189687.36 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet GlycoMap (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Breast Cancer is the most commonly diagnosed cancer in Europe and remains the first cause of cancer death in women (nearly 92,000 deaths in 2020). Precision medicine uses data-driven insights to reflect the heterogeneity of patients and improve cancer care by offering actionable oncology treatment options. Tumour tissue heterogeneity is the leading cause for inter-patient variation in treatment response. One of the largest sources of tissue heterogeneity arises from post-translational glycosylation of proteins and aberrant glycosylation is a hallmark of breast and other cancers. Yet, substantial gaps remain in our knowledge of cancer glycans. Glycomics (the comprehensive study of the glycome) offers the potential to provide the global glycosylation status (GlycoMap) of a patient and shed new light on tumour heterogeneity to guide precision medicine. This project aims to address the substantial knowledge gap in breast cancer tumour glycosylation data by developing an integrated glycomics workflow to produce patient-specific 'GlycoMaps'. By including glycosaminoglycan (GAG) 'omics from intact GAGs for the first time, combined with other glycan analyses will enable the generation of Breast Cancer GlycoMaps from resistant and drug-sensitive patient-derived organoids (mini avatars of tumour tissue), defining residual tumour tissue following treatment that causes relapse and metastasis. The mission and design of the GlycoMap project is to train the researcher, who has a background in GAGomics, proteoglycan biology and bioinformatics, with expanded skills and expertise in N-/O-glycomics, organoid culture, hi-resolution 3D imaging and advanced bioinformatics in the context of breast cancer, augmenting her future career opportunities, as well as establishing unbiased top-down integrated glycomics to support breast cancer analyses, diagnostics and the development of novel treatments.

Mots clés : glycosaminoglycans, glycomics, glycans, breast cancer

Participants :
- Université métropolitaine d'Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 226751.04 €
- Princess Máxima Center (Pays-Bas) — Partner, associated partner, Autres, subvention : 0.0 €
Projet ROSAMA2 (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Bulk metallic glasses (BMGs) are promising materials to support the goal to make EU climate-neutral by 2050, and promote the growth of many industrial sectors such as biomedical. Thanks to their amorphous nature, BMGs offer an outstanding combination of high strength, corrosion/wear resistance and biocompability. Recently, Additive Manufacturing (AM) has been proposed as a solution to tackle the size limitation of the conventional casting production of BMGs. Still, many challenges remain to develop defect-free parts with mechanical performances comparable to their as-cast counterparts. In addition, to date, no post-processes can be applied to close porosity and improve quality without altering the amorphous state of the material. The project ROSAMA2 hosted by SIMaP in Grenoble aims to develop a RObust and Sustainable Additive Manufacturing of Amorphous Metallic Alloys by laser powder bed fusion. In situ X-ray microtomography will enable the 3D reconstruction of the deposited material layer-by-layer using a unique miniature system designed for usage at synchrotrons. The high brilliance of the radiation will reveal the quality of the powder bed, the morphology of the deposited material, the presence of defects in its volume and their evolution upon processing. Doing so, strategies to eliminate porosity in situ will be proposed. The printed BMGs will be evaluated to determine the role of defects, structural and chemical heterogeneities on the mechanical performances, by means of X-ray nanotomography, advanced thermal analyses, high resolution microscopy, nano-indentation and compression testing. In a final effort, strategies to enhance powder recyclability and limit pick-up of oxygen, harmful to the glass forming ability, will be developed, and the role of process atmosphere composition will be considered. Besides strengthening EU’s position on the AM market, ROSAMA2 will develop and consolidate Dr. Pauzon’s profile and secure future position in academia and industry.

Mots clés : bulk metallic glasses amorphous additive manufacturing powder bed fusion robust sustainable in situ x ray tomography synchrotron defects oxygen impurity mechanical performance recyclability

Participants :
- Université Grenoble Alpes (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 218160.27 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet RIDGES (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Long-runout landslides with longitudinal ridges are amongst the most catastrophic type of mass movements and the least understood. Only ancient (i.e., ~60 ka/7 ka) long-runout landslides with longitudinal ridges are preserved in the terrestrial geomorphological record. This geomorphological record is critical to understanding where, when, and how these catastrophic events occurred, thus critical to addressing a key question in hazard assessment: how likely events of similar magnitude to those of the past are likely to occur in the future?  The RIDGES project aims to answer this important question: are long-runout landslides with longitudinal ridges related to climate change phenomena, i.e., deglaciation and permafrost degradation? This project will study well-preserved long-runout landslides with longitudinal ridges in Iceland, a unique region for its high spatial density of well-preserved long-runout landslides with and without longitudinal ridges, not seen anywhere else on Earth. By using an original combination of interdisciplinary methods and a multi-scale approach to understand the chronology and the complexity of large slope instability in deglaciated areas, which remain major geomorphological issues worldwide, RIDGES will directly reconstruct paleo-climatic and paleo-environmental conditions during which landslides with longitudinal ridges formed in Iceland.  The results from RIDGES will help better understanding whether the occurrence of catastrophic landslides with longitudinal ridges is related to climate change phenomena. If a correlation is found, it will help mitigating the risks associated with mass movements in rapidly deglaciating regions due to climate change, such as Greenland and Alaska.

Mots clés : geomorphology longitudinal ridges landslides paleoenvironment earth

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 226420.56 €
Projet KinSiGHT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The Na-Qiangic (NQ) languages are an endangered subgroup in Sino-Tibetan (ST), spoken by ethnic minorities in the Hengduan Mountains of Southwest China. The NQ-speaking area is home to great diversity of kinship and marriage patterns, where one finds zouhun, a non-conjugal visiting system, practiced by matrilineal communities. Many questions remain unanswered: Are matrilineal kinship and zouhun vestiges of once more widespread practices? Did these diverse kinship patterns originate from a common ancestral system? What are the factors leading to the diversity of family structures in this area? To answer these questions, KinSiGHT focuses on the Gyalrongic (NQ)-speaking area in northwestern Sichuan, and uses linguistic methods to trace transformations of kinship systems of the Gyalrongs. The two interlocking themes of this investigation will be (i) the directionality of transformation from the Proto-Gyalrongic kinship system to the synchronic systems, and (ii) correlations among historical changes in kinship systems, marriage patterns and NQ phylogeny. KinSiGHT will advance our understanding of the Gyalrongic kinship patterns and their values in revealing the origin of family structure in the Hengduan Mountains, as well as general principles of kinship transformation. KinSiGHT will enhance collaborations between linguists and anthropologists. During this fellowship, the PI, Shuya Zhang, will be based at the Trinity Centre for Asian Studies (TCD), where she will benefit from instructions from Prof. Nathan Hill in practicing historical linguistic methods. During the secondment at the Center for Himalayan Studies (CNRS Paris), she will work with Dr. Stéphane Gros, a prominent anthropologist specializing in ethnic minorities in Southwest China. The fellowship will enable the PI to become a leading female scholar in ST kinship studies, and will position her to prepare a competitive ERC grant application, while opening up new career opportunities in ethnological museums.

Mots clés : chinese ethnic minorities, gyalrongic languages na qiangic, sino tibetan , kinship systems, marriage patterns, historical linguistics, linguistic phylogeny

Participants :
- Trinity College (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 199694.4 €
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet ARTISTS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Rock art, one of humanity’s earliest symbolic expressions, is considered a milestone in human evolution. Despite extensive global research, little is known about the specific patterns and rhythms of how past societies used rock art sites. ARTISTS project seeks to understand patterns of use of rock art sites, which hold a special place in prehistoric societies' physical and symbolic territories through three main objectives: 1) Identify and characterize anthropogenic traces (such as chars) from complementary sites (geography, climate and chronology) in Spain and France using an integrated multi-method protocol, 2) Document the temporality of rock art site use with micro-chronological precision and calendar accuracy, and 3) Synthesize findings to understand the dynamics of site use from archaeological and anthropological perspectives. To achieve these goals, Dr. Vandevelde will study sooty speleothems, which are exceptional archives for micro-chronological research. They offer precise radiometric dating and high-resolution paleoenvironmental data through annual laminae. They also serve as anthropogenic records, capturing traces of human activity, such as soot from lighting, allowing the construction of a relative chronology of visits at a site. These detailed chronologies can reveal occupation patterns on an annual scale, providing groundbreaking insights into human mobility. By targeting rock art sites, ARTISTS will shed new light on occupation dynamics of sites visited for symbolic activities. A decorated cave is not a vitrified site, and recent studies show that the temporal complexity of rock art sites is much greater than previously believed. By combining innovative in-lab and on-site multidisciplinary methods from archaeology and geosciences, ARTISTS can reveal this complexity with unprecedented accuracy. For the first time, integration of rock art sites into annual or multi-year cycles of nomadism will be discussed directly from archaeological data.

Mots clés : european archaeology, archaeology of fire, pyroarchaeology, high temporal resolution, temporality, rock art

Participants :
- Université de Cantabrie (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209914.56 €
- University of Córdoba (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université du Québec (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €