Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet QUANTUMLHC (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

The main motivation driving the research in collider particle physics is the possibility to address some of the mysteries in the fundamental inner workings of our Universe and to answer to questions left open by the Standard Model of particle physics (SM). Despite the unprecedented energy reached and the large amount of data collected at the Large Hadron Collider (LHC) no convincing evidence of physics beyond the SM has been found. The start of the third LHC data-taking phase (2022) call for novel and unconventional approaches to search for new phenomena, looking in directions yet to be explored. This project proposes to exploit quantum effects, and in particular entanglement among particles as a new observable to probe interactions at high scales. By leveraging on quantum information concepts and techniques, I will explore new experimental strategies to analyse collider final states searching for SM extensions, through unexpected modifications of quantum correlations. The sensitivity of quantum correlations to new physics effects will be investigated both through a model independent effective approach as well as through specific models encompassing new resonances. This proposal aims to provide a first complete guidance and therefore to open the way to LHC experiments on how to perform and interpret measurements of quantum observables in the WW and top pair final states, at low as well at high energy, with specific techniques optimised for each kinematical region. Its ambition lies not only in the scope but also in development of new experimental technique based on charm tagging that has the potential to enlarge the data sample and therefore significantly extend the reach of the new physics searches.

Mots clés : quantum information observables, data analysis, phenomenology, new physics searches

Participants :
- Université de Bologne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet TQC (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Arguably one of the biggest difficulties facing quantum engineers is quantum control. Quantum systems are incredibly sensitive which is one of their greatest assets, but also and their Achilles’ heel. One can leverage the general theory of feedback and measurement-based quantum control to enhance quantum capabilities to a desired functionality, but there is a problem as quantum systems can be perturbed by those very measurements leading to a loss of control.  The aim of this proposal is to develop a general and widely applicable thermodynamic framework of measurement-based quantum control which is abbreviated to the Thermodynamics of Quantum Control (TQC). Studying quantum control through the lens of thermodynamics is a novel idea and allows one to utilise the powerful tools developed in quantum thermodynamics. I will unify the stochastic behaviour of quantum measurements and quantum control with the state-of-the-art research in stochastic quantum thermodynamics. We will validate our proposal by developing testable protocols that can be implemented using current quantum technology and will commence designs with an experimental team in the later stages of the project. The timely results will answer fundamental questions regarding the effectiveness, precision, and efficiency of measurement-controlled sensors and engines. The research will be carried out in the perfectly suited 'Thermodynamics and energetics of Quantum Systems' (QuSys) group of Prof. John Goold at Trinity College Dublin.

Mots clés : quantum measurement and control, stochastic quantum thermodynamics

Participants :
- Trinity College (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
- Université d'Oxford (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet TopCellComm (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The processes through which cells sense, adapt, and respond to their environment are fundamental to development and homeostasis. Mechanical forces, exerted and experienced by cells, can act as messengers, however, the exact mechanisms by which cells perceive and generate forces have not been elucidated yet. Here, I aim to explore a phenomenon, in which cells autonomously exploit folding and topographical restructuring of their underlying substrates as a means of self-induced guidance and communication mechanism to coordinate their individual and collective behaviours. Guided by the Prof. Doostmohammadi group’s recent collaborative study, revealing cell-generated forces from the folding patterns in real-time, I will develop a computational framework and will use it to numerically dissect the crosstalk between cell activity and self-generated patterns of substrate deformation. To model cell-generated forces, I will employ the phase-field formalism coupled will be coupled to the mathematical model of nonlinear substrate deformation. By utilising available data, I will calibrate the model and carry out simulations to uncover the underlying mechanics of single cell interactions with the substrate and emergent topographic anisotropies. I will then extend the model to consider interaction between pairs of cells on a substrate and elucidate the phenomena of topography-mediated cell communication. These actions will act as a first step towards the interconnection between multicellular-scale self-organized topographic modification and cell migration. Thus, this project at the intersection of mathematics, biology, and bioengineering will be a significant step towards delivering a state-of-the-art predictive tool for the design of biomaterials for regenerative medicine.


Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 214934.4 €
- Université d'Oxford (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet POWO (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

There are no studies that classify and analyse the speeches ascribed to the Julio-Claudians. POWO would be the first collection and classification of all statements attributed to the Julio-Claudian emperors, including dicta, sententiae, speeches, and dialogues, both those included in official imperial documents, containing self-constructions and those reported in literary sources, which convey constructions of emperors in historiography. No study analyses the function of Julio-Claudians' speeches concerning the strategies of communication. POWO intends to fill this gap and produce the first collection and classification of imperial speeches. By supplying an extensive analysis of imperial statements, POWO will investigate the intra-textual and inter-textual levels and identify tragic and rhetorical patterns emerging from these speeches. POWO does not aim to study imperial speeches to ascertain their historical verisimilitude but rather to investigate their use in modelling the representation of the princeps as the archetypical character, who conveys the author’s political judgement. POWO relies on two ground distinctions: the first draws a line between official imperial documents (containing self-constructions) and the literary texts (including constructions of emperors); the second between statements reported in direct speech (oratio recta) and those transmitted in indirect speech (oratio obliqua). POWO will embrace multiple and interdisciplinary approaches: Alongside established scholarly techniques of textual philology, textual criticism, close reading of texts, and source criticism, it will use literary theory, the pragmatics of communication (including politeness and impoliteness theory), doublespeak theory, and adopt a historiographic perspective for contextualisation to reconstruct the voices of the Julio-Claudians.

Mots clés : julio claudian dynasty, speeches, vertical communication, doublespeak, ancient rhetoric

Participants :
- Université Columbia (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Rome « La Sapienza » (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 265099.2 €
- Université de Palerme (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet InVitroFutures (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

In Vitro Futures is a critical and innovative anthropological analysis of embryo adoption from a transnational, multi-sited and comparative perspective between Canada and Spain. The project is built around 3 fundamental, yet unanswered research questions: RQ1. From a comparative point of view, what narratives exist behind embryos adoption and how are these meanings and practices shaped or promoted by social determinants such as nationality/country, bio-political institutions, gender/sexuality, and class? RQ2. How do clinics and fertility specialists influence embryos adoption practices? RQ3. How is biological relatedness referred to by embryo donors and embryo receivers in Canada and Spain? The research aims will be reached through 3 Research Objectives (ROs), corresponding to the 3 research questions outlined above. RO1. Biomedical Issues, Moral Discourses, Salvific Logics. In the current framework of embryos adoption management RO1 will explore and study how medical actions contribute to construct a specific narrative relating to the extra embryos. RO2. To identify how these meanings and practices are coerced or promoted by social determinants such as nationality/country, bio-political institutions, gender-sexuality, class, race, in the presence or absence of a regulatory framework, this research requires the comparison between the two cases: embryo adoption in Spain and in Canada. RO3. Relatedness in Embryo Adoption Programs. RO3 will examine empirically the meanings and practices of family relatedness in the transition to parenthood of families created through this practice. My hypothesis is that the ways in which the embryos are represented and the impact of absence/presence of a law on embryo donation may have significant implications for decision-making around the fate of spare embryos.

Mots clés : anthropology of reproduction ivf embryo donation embryo adoption anthropology of kinship sociology of health medical anthropology ethnography

Participants :
- Université du Québec (Canada) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Bologne (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 256442.88 €
Projet SYNERGIES (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The incidence and socioeconomic burden of osteochondral (OC) diseases are growing worldwide, representing a major challenge for the healthcare systems. Tissue Engineering (TE) emerged as a promising alternative to the current ineffective OC disease treatments. However, state-of-the-art OCTE strategies are still unable to create functional engineered tissues, mainly due to their inability to replicate in vitro the complex physicochemical environment of the native OC tissue within the articular joint, making OC regeneration a critical unmet medical need. The ambitious purpose of the SYNERGIES project is to fill this gap by developing a pioneering smart biomimetic bioreactor-based platform able to culture OC constructs under physiologically and clinically relevant multi-physical stimulations in a controlled and adaptive manner. Cutting-edge in silico modelling and machine learning (ML) tools will be employed for the operational parameters optimization and for the smart automated control of the bioreactor platform, respectively. The SYNERGIES platform will enhance the knowledge of OC tissue mechanobiology beyond the state-of-the-art and guide the improvement of protocols for the production of functional OC substitutes, which will be suitable in vitro models for OC disease research and drug screening, paving the way for new effective therapies.  The proposed Fellowship will enable a highly interdisciplinary collaboration between myself, a talented post-doc with a strong track record on biomaterial scaffolds for OCTE, and the supervisors, leading experts on bioreactor engineering and in silico modelling/ML tools. The excellent working conditions at Politecnico di Torino and 7HC will promote my professional development, offering me new scientific expertise and leadership skills, significantly widening my career perspectives. Ultimately, SYNERGIES outcomes will be of remarkable benefit to the European biomedical sector, contributing to EU excellence and quality of life.

Mots clés : smart adaptive bioreactor osteochondral regeneration in vitro biomimetic investigation platform multi physical stimuli bone articular cartilage in vitro disease models mesenchymal stem cells

Participants :
- École polytechnique de Turin (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
- 7hc societa a responsabilita limitata (Italie) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet ANFPEP (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Asymmetric nucleophilic fluorination remains one of the most challenging transformations in organic chemistry. In light of the importance of chiral fluorochemicals for the pharmaceutical sector, the development of innovative enantioselective fluorination methods with alkali metal fluoride is highly desirable. In this work, we propose to merge two conceptual manifolds, namely peptide-based organocatalysis and hydrogen bonding phase-transfer catalysis. We propose to investigate experimentally the binding ability of an extensive β-turn-based peptide library to fluoride, a fundamental unprecedented study. The insight into the binding profiles and conformational properties of these peptides will be essential for developing an asymmetric catalytic nucleophilic fluorination procedure. In this context, we shall first focus on synthesising pharmaceutically relevant cyclic β-fluoroamines. Subsequently, the peptide-catalyst design will be further refined by introducing a substrate binding region for targeting aryl amides, esters, thioesters, and sulfones. Upon completion, this work will provide medicinal chemists with a novel peptide-catalysed asymmetric nucleophilic fluorination reaction, an advance expanding the scope of organocatalytic nucleophilic fluorination reactions.

Mots clés : asymmetric nucleophilic fluorination, organocatalysis, phase transfer catalysis, peptide catalysis

Participants :
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet Li-PIEs (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

I propose combining organic synthesis, theoretical modelling, and materials science to develop a fundamentally new type of lithium- conducting electrolyte. Electrolytes are a vital part of modern life – for example, they are key components of the lithium-ion batteries powering personal electronics and electric vehicles. The electrolyte acts as the medium to transfer charges between the electrodes and its properties and performance depends on the type of material used. Different requirements associated with different sizes and types of devices is driving the development of new electrolyte materials. Traditionally, these materials are classified as either solid- or fluid-phase electrolytes, and the mechanisms of charge transfer differ between the two phases. Recently, a new type of electrolyte has been developed by the host PI that can function as either a solid or liquid electrolyte without losses in performance – they are phase-independent electrolytes (McGonigal et al., Science, 2024, accepted). However, these materials transport anions, while most batteries require cation-conducting electrolytes (e.g., lithium ions). To harness the potential of this new class of electrolytes, this concept must be adapted to apply to cation-conducting electrolytes, and this requires the development of new molecular designs, their synthesis and characterisation. I will use DFT to model the structure and assembly of cyclopentadienide anions to identify candidates that have suitably diffuse charge and flexible structures to act as phase-independent electrolytes. I will then synthesise the top candidates and characterise their phase transition temperatures, phase structures, and lithium-ion conductivities. The relationship between molecular structure and the material properties will be developed to allow for the rational design of phase independent electrolytes. This will generate new research directions for the development of high-performing organic electrolytes.

Mots clés : organic ions, discotic liquid crystals

Participants :
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet METrIC (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

Cell migration is at the core of many biological processes in development and cancer progression. Epithelial-to-mesenchymal transition (EMT), i.e. the temporary and reversible switching between epithelial and mesenchymal phenotypes, plays a crucial role in increasing the motility and invasiveness of cells, representing a potential therapeutic target in many biomedical areas. With the surge of omics data, we are now more than ever able to characterise the phenotypic properties of cells and require theoretical frameworks which can effectively integrate such information to help us predict tissue-level behaviours for optimisation of therapeutic interventions.  My project is devoted to the development of such a theoretical framework, in which cell migration through the extracellular matrix (ECM) is mediated by the cell phenotypic state which may change guided by mechanistic rules for EMT, incorporating information on the cell phenotypic state coming from omics data.  I will focus on mathematical models comprising nonlocal partial differential equations of the evolutionary dynamics of space- and phenotype-structured cell populations. By representing cell phenotypes on a continuum, the models can capture intratumour heterogeneity and hybrid phenotypes, and may be directly linked with transcriptomic and proteomic data. This project will tackle the analytical and numerical challenges stemming from movement in physical space, modelling heterogeneous cell motion in the ECM, and complex phenotypic drifts, incorporating a description of core regulatory circuits for EMT, yet to be investigated in a unified framework. Moreover, we will address the inverse problem of employing transcriptomic data to infer the nonlinear impact of environmental factors on the core regulatory circuit mediating phenotypic changes, to this day an open problem.  The outcomes of the project will advance mathematical, biomedical and interdisciplinary research.

Mots clés : mathematical models nonlocal partial differential equations asymptotic analysis numerical simulations data integration phenotypic adaptation cancer invasion epithelial to mesenchymal transition

Participants :
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet EMPDANZ (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The proposed research project has a two-pronged aim. Firstly, it examines copies of sixteenth- and seventeenth-century playbooks held in Australian and New Zealand libraries in order to bring a transnational framing to the reception history of the culturally influential literary genre of early modern English drama. Secondly, it examines how data relating to these copies can be presented to the international scientific community in a way that foregrounds these copies’ specific geographic and political contexts, in line with approaches to the decolonisation of knowledge that reflect the books’ Southern Hemisphere settler colonial locations. Scholars in the field of book history are beginning to confront this field’s reliance on material artefacts (i.e. rare books) that were acquired and preserved with the aid of wealth obtained in problematic circumstances, but thus far the focus of such confrontations has been Northern Hemisphere copies and collections. In creating outputs focused instead on data drawn from inspections of Southern Hemisphere collections of rare books, and in developing an online resource that provides an international model for how to acknowledge problematic acquisition histories in culturally sensitive ways, “Old Books, New Worlds: Early Modern English Printed Drama in Australia and New Zealand” offers a significant and transformative intervention in the field of book history. It is relevant both to the 2023-2024 Work Programme to produce “Innovative research on the European cultural heritage and the cultural and creative industries – building our future from our past” and also to the 2023-2024 Work Programme to facilitate “A human-centred and ethical development of digital technologies”.

Mots clés : book history, early modern drama, digital humanities, australia, new zealand, settler colonial history, decolonisation, critical bibliography, critical archival studies, critical librarianship

Participants :
- The University of Melbourne (Australie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Victoria de Wellington (Nouvelle-Zélande) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université d'Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €