Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet eUMaP (Horizon 2020, appel à projets 2020)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : SIGNED

In 2020 Europe went through a very significant economic and social crisis, namely the response to the disease of Coronavirus. Over 200 million European citizens were obliged to observe restrictive measures, in some cases lock down measures, in order for governments and local authorities of the Member States of the European Union to address and limit the problem of the spread of the virus. Through this situation a number of problems emerged, one of which relates to the management of building utilities under such conditions. Specifically, in a very few days most of the activity of the European Economy shifted from the office environment to homes, leading to several problems in relation to with the completeness and integrity of utilities such as power outages, water shortage and insufficient internet connection. The initiative entitled Development of Utilities Management Platform for the case of Quarantine and Lockdown - eUMaP aims to implement all those activities that will lead to the development of an open platform through which local authorities will be able to plan and manage the demand and supply of building utilities in case of quarantine or lock down. The platform will be developed through a Research and Innovation Staff Exchange (RISE) program. eUMaP platform will be based on the rational of earth observation, and the recording of the required network information in open BIM platforms of five European capital cities (Rome, Berlin, Athens, Vilnius, Nicosia). The platform will be piloted in study areas with the aim of optimizing it and delivering it as an open platform upon completion of the program.

Mots clés : covid 19, utility management, lockdown, energy management, waste management, water management, telecommunication network

Participants :
- Space systems solutions (s3)ltd (Chypre) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 110400.0 €
- Kaunas University of Technology (Lituanie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110400.0 €
- Cleopa (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 69000.0 €
- Consorzio Nazionale Interuniversitario per i Trasporti e la Logistica (Italie) — Partner, beneficiary, Recherche, subvention : 110400.0 €
- Alma sistemi srl (Italie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 156400.0 €
- Frederick University (Chypre) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 128800.0 €
- Aristotle University of Thessaloniki (Grèce) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 110400.0 €
- Geosystems hellas it kai efarmogesgeopliroforiakon systimaton anonimietaireia (Grèce) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 105800.0 €
- Uab caverion lietuva (Lituanie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 59800.0 €
Projet IaM NUBIAN (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

In 652 CE the successful expansion of Islam into Africa was halted at the gates of Dongola. While the historical significance of this ‘Nubian dam’ is well known, its sociocultural dimension also for subsequent developments in the region remains completely unexplored. IaM NUBIAN addresses this gap by examining how Nubian identity was shaped in the aftermath of this world-historical event and how it changed over time to witness the rise to glory and eventual fall of Christian Nubia in the 15th century. Using the extensive, but hardly exploited written evidence (documentary and literary) produced inside and outside Nubia in 4 languages (Greek, Coptic, Old Nubian, and Arabic), I will study textual and contextual means of expressing ‘Nubianness’ in 4 case studies on (1) linguistic strategies of (self-) presentation, (2) gender-determined identity, (3) the role of inscriptions in public space, and (4) how external sources presented Nubians. For the first time in Nubian studies, traditional historical disciplines (e.g. philology, papyrology, epigraphy, history) will be combined with insights from social sciences (sociolinguistics, identity and memory studies) and statistics to unlock the sophisticated interplay of text and context that underlies the studied writings. Moving well beyond the boundaries of current knowledge and approaches, IaM NUBIAN shifts the focus from the political-religious to the sociocultural to understand the historical processes that shaped medieval Nubian society. IaM NUBIAN is best executed in the Leiden Institute for Area Studies with its interdisciplinary approach to studying society at large, while Freie Universität Berlin offers crucial additional digital humanities and sociolinguistic expertise. Through an intensive cooperative and interactive research and training programme I will gain crucial linguistic, disciplinary, and professional skills, which will put me in position to obtain an ERC Consolidator Grant and a permanent academic position.

Mots clés : christian nubia, nubian egyptian relations in middle ages, muslim christian relations

Participants :
- Leiden University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 187572.48 €
Projet BonePainII (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : CLOSED

In Europe 20 - 30% of adults are affected at any one time by musculoskeletal pain such as arthritic pain, lower back pain, pain from osteoporotic fractures and bone metastasis, and also most rare bone diseases are very painful. Despite a huge negative impact on the quality of life of the patients and on society as a whole, no specific treatment is yet available. Therefore, there is a strong need to train highly skilled researchers within bone pain and thereby make the foundation for improved therapies. In this proposal we bring together 3 industrial beneficiaries, 8 academic beneficiaries, and one industrial partner all committed to train a new generation of 15 creative, entrepreneurial and innovative early stages researchers in bone pain research and transferable skills. The early stages researchers will train with some of the foremost neuroscientists and bone researchers in academia and industry across Europe. The BonePainII training network will provide the early stage researchers with expertise that will enable them to gain high level employment both in academia and industry. In a multidisciplinary, intersectoral and integrated project we will develop advanced 3D microfluidic in vitro platforms and high throughput techniques to investigate bone-neuron interactions; validate and investigate novel in vivo models of bone pain including a rare bone disease; and using cutting-edge technologies to identify key mechanisms underlying bone pain in osteoarthritis, rheumatoid arthritis, and cancer-induced bone pain.

Mots clés : bone, pain, animal models, skeletal diseases

Participants :
- Karolinska Institutet (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 281982.96 €
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 595044.0 €
- Transpharmation ltd (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University Medical Center Utrecht (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 531239.76 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 606345.12 €
- University of Porto (Portugal) — Partner, beneficiary, Recherche, subvention : 237720.24 €
- Nordic Bioscience (Denmark) (Danemark) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 595044.0 €
- Natural and Medical Sciences Institute (Allemagne) — Partner, beneficiary, Recherche, subvention : 252788.4 €
- University of London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 303172.56 €
- Cellectricon ab (Suède) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 281982.96 €
- AstraZeneca (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 303172.56 €
Projet SMILED (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

In Europe, 52 million people are living with diabetes, with more than 90% of them having type 2 diabetes (T2D), a multifactorial disease associated with obesity and sedentary lifestyle. It leads to severe complications such as cardiovascular events and constitutes an unmanageable economic burden. Skeletal muscle inflammation is emerging as a potential contributor to T2D. Inflammation occurs during exercise and repair and is a hallmark of myopathies, suggesting that it plays crucial roles in skeletal muscle homeostasis. Despite the fact that exercise is associated with inflammation, physical activity has beneficial effects on T2D, which highlights the ambivalent role of muscle inflammation in controlling glucose homeostasis. Epigenetic processes are potential molecular links between diseases and environmental factors such as diet and exercise. Abnormal promoter methylation of inflammatory genes was recently suggested in adipose tissue during obesity, but little is currently known about epigenetic regulations in muscle during exercise and diabetes. Surprisingly, it is unknown whether there is any parallel between local inflammation of muscle and T2D and no therapeutic strategies currently target skeletal muscle for T2D treatment. The overall aim of this proposal is to determine the interaction between inflammation and the metabolic response to exercise and T2D to define potent interventional strategies that can improve insulin sensitivity. It will identify what type of inflammatory response induces the greatest metabolic effect on signal transduction and expression of genes through profiling DNA methylation, chromatin structure and small RNAs. It will use primary cell cultures from human biopsies to (1) obtain proof of principle that the beneficial effect of exercise on metabolism is dependent on inflammation, and (2) translate these discoveries into innovative exercise and anti-inflammatory intervention strategies to improve insulin sensitivity.

Mots clés : skeletal muscle, exercise, diabetes, inflammation, epigenetics

Participants :
- Karolinska Institutet (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185857.2 €
Projet EHT-CaMKII (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

In Europe, as observed in other parts of the world, cardiovascular (CV) diseases represent the leading cause of death. In the European Union, CV deaths account for 1.9 million deaths per year, and treatment costs for CV disease amount to an estimated 200 billion Euros per year. CV diseases encompass various pathologies that can lead to a progressive loss of cardiac contractile function and the clinical syndrome of heart failure (HF), including ischemic heart disease and myocardial infarction. Drug therapy can successfully slow down the progression of HF and reduce mortality, but it cannot revert the loss of myocardium and thus provide no curative approach. The engineering of 3D heart tissues (EHTs) has been developed in 1994 and, in combination with the recent availability of human induced pluripotent stem cells (hiPSCs), may represent a novel, promising technique to treat such cardiac pathologies. EHTs are artificial living and functional 3D heart tissues that could replace injured or malformed heart and restore normal cardiac function on the one hand, and help modeling cardiac diseases and testing drugs in a human heart context on the other hand. However, despite the last years progress and clear advantages compared to 2D cultured hiPSC-cardiomyocytes (CM), EHT-CMs do not reach a fully mature phenotype matching that of isolated CMs from the adult human heart. Based on preliminary results obtained in the host laboratory, a set of indices suggest a role of CaMKII in the EHT-CMs maturation process. The objective of this proposal is thus to determine whether and, if yes, to which extent different CaMKII isoforms are involved in EHT-CM maturation. The EHT-CaMKII project could have very interesting impact on the EHT-CM maturation enhancement and, consequently, on numerous EHT applications encompassing cardiac repair, drug screening or disease modeling. In addition, it will contribute to understanding the biological role of CaMKII in CM biology.

Mots clés : engineered heart tissues  ehts, camkii, human induced pluripotent stem cells  hipsc

Participants :
- Universität Hamburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 159460.8 €
Projet WEARTUAL (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

In WEARTUAL, I will investigate and develop ways to integrate wearables into virtual reality (VR) environments in a way that enhance the immersiveness of the VR experience. In particular, I will investigate the possible functions and interaction modalities of wearables for providing an improved user experience in VR by developing prototypes and including users in the design process. As a result, I will obtain wearable prototypes, comprehensive user experience data and design guidelines that will inform the human-computer interaction (HCI) literature about the right ways for designing wearables for VR environments. WEARTUAL is a user-oriented research through design project that will adopt an interdisciplinary approach by using the disciplines of interaction design, game design, product design, engineering and psychology. Mainly, I will adopt a research structure that encapsulates user inclusion, ideation, prototype development and user experience experiments and evaluations. In this project, I will transfer my knowledge of designing games, wearables and prototyping for design research activities, while supervision of Prof. Juho Hamari (Tampere University, Finland) will contribute to game design and gameful experience measurement. Prof. Hamari leads the Gamification Group (GG), an interdisciplinary team composed of 18 members whose research is focused on game research, gamification and immersive technologies, such as virtual and augmented reality. In this sense, his experience in leading complementary research teams will also help me develop as a leader for directing research groups. I will also closely collaborate with the members of the GG who are experienced in conducting research on and developing VR content.

Mots clés : wearables, playful interaction, research through design, pervasive gaming

Participants :
- Tampere University (Finlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202680.96 €
Projet SEDILAND (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

In a globally changing world, sediment regime disturbance has emerged as a dominant actor in the modification of river catchments. The sediment regime refers to the sediment budget (amount, type and timing of sediment inputs, outputs and storage) of a river system. Studies of sediment regimes in medium and heavily land cover modified catchments are scarce to the extent that even the likely direction of change of sediment yield compared to background conditions is unknown. Without understanding the changes in the sediments inputs of rivers we are potentially missing half the story. The main and novel research questions within the SEDILAND project are: how (and how rapidly) land cover changes impact on the sediment regime of a river catchment and ultimately on the river channel morphology?; Is there a critical tipping point that guarantees the reversibility of the sediment regime disturbance to a pre-developed scenario?; and if not, how can we assist in fostering a better environmental and territorial management in catchments that preserve natural processes (flow and sediment regime)?. These questions will be tackled thanks to the collaboration between IPE and IHE. These institutions are world authorities on assessing changes on land cover, sediment regime and population dynamics. In turn, the applicant has a broad knowledge in the field of Geoenvironmental Processes. The applicant will be trained in leadership, management, funding, supervision and communication skills. Jointly this team is in a position to push the boundaries of sediment regime disturbance knowledge far ahead, with the ultimate intent to allow the applicant to train through research and become an independent researcher in Europe. This MSCA addresses two of the H2020 Societal Challenges: “Food security, sustainable agriculture and forestry, marine and maritime and inland water research, and the Bioeconomy”, and “Climate action, Environment, Resource efficiency and Raw materials”.

Mots clés : sediment regime disturbance, land cover change and variability, river channel morphology, river catchment, environmental risk assessment, population dynamics

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 160932.48 €
Projet TEAPOT (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

In a strong magnetic field and at extremely low temperatures, a two-dimensional sheet of electrons can transition into a strongly correlated state: the fractional quantum Hall (FQH) state. The one-dimensional edge of such a sheet is by itself a viable experimental platform for controlled studies of a wide range of quantum phenomena. Recent experimental developments have enabled detailed thermal transport experiments for probing the properties of such FQH edges. Despite this progress, many questions on edge energy propagation, equilibration, and redistribution remain unanswered. The theoretical TEAPOT project will address these questions by introducing new observables - heat noise, mixed noise and delta-T noise -for disordered transport on general FQH edges. The main goal is to use these promising quantities as novel and complementary tools for probing emergent transport phenomena, not directly or not uniquely related to the electrical charge. TEAPOT will be led by the experienced researcher (ER), as a postdoc project in collaboration with the Supervisor: an expert on quantum thermodynamical processes in nanoscale devices. The ER has recently developed a theoretical model connecting the propagation of charge, heat, and charge noise on general FQH edges. With this substantial preparation, TEAPOT will reach its goal by generating a full theoretical description of the interrelated edge propagation of charge, heat, charge noise, heat noise, delta-T noise, and mixed noise. This description will be derived by the ER and the Supervisor, combining chiral Luttinger liquid techniques with concepts in quantum thermodynamics. TEAPOT will enable novel ways to design and analyze FQH experiments, improving the fundamental understanding of strongly correlated quantum behaviour on the nanoscale. In turn, such an understanding is crucial for the design of novel types of quantum devices, e.g., for small scale thermodynamical or quantum computational applications.

Mots clés : fractional quantum hall effect, chiral edge states, chiral luttinger liquid, noise, quantum transport

Participants :
- Chalmers University of Technology (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 203852.16 €
Projet Heart2019 (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

In all vertebrates, heart development is dependent on the interplay of several cell populations of distinct embryonic origin. One of these cell populations is the cardiac neural crest (CNC) which contributes to the outflow tract and spiral septum in amniotes. However, CNC cells also migrate to the ventricles and differentiate into cardiomyocytes both in zebrafish and in amniotes. Interestingly, recent results from one of the host lab have shown that CNC-derived cardiomyocytes in zebrafish have an extraordinary capacity for regeneration and that ablation of these cells blocks heart regeneration. Here, I will explore whether this regenerative capacity of cardiomyocytes is unique to zebrafish or represents an ancestral state of characters for vertebrates in general. The goal of the proposed research is to use phylogenetically important vertebrates (lamprey, sturgeon, and axolotl) to answer fundamental questions about the development of the CNC and its role in heart regeneration across vertebrates. Thus, we aim to i) examine the fate of CNC in three species; ii) determine the potential of CNC to differentiate into cardiomyocytes; iii) examine the gene expression profile of CNC cells and neural crest-derived cardiomyocytes; iv) ablate neural crest-derived cells and examine their function in heart regeneration.

Mots clés : heart, development, cardiac neural crest cells, stem cells

Participants :
- University of South Bohemia in České Budějovice (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 255756.24 €
- California Institute of Technology (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €