Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet ERNI2014 (Horizon 2020, appel à projets 2014)
Action : European Researchers' Night
Statut du projet : CLOSED

Following previous eight years of successful implementation of European Researchers' Night in Israel we will have: o Venues covering the whole country. o Involvement of the academic community including Israel Ministry of Science, Technology and Space (MOST), all major research universities, leading collages and three science museums. o Awareness campaign at national level managed and funded by the Israel Ministry of Science, Technology and Space. o Groups of junior-high and high-school students (ages 12-18) will be invited by each partner to take part in each venue. We are ready and proud to implement European Researchers' Night 2014 & 2015. • All of the partners involved in the project have the experience of running successful European Researchers' Nights events. • With the successive increase in number of visitors along the years and the reputation of the event we are expecting more than 50,000 visitors each year. • Main theme for 2014 will be "Water & Marine Sciences research". Main theme for 2015 will be "Brain Research" which is very attractive subject to the special 10th anniversary event. • Same management as in 2011, 2012, 2013 successful events. • Proposal covers both 2014 & 2015 European Researchers' Night events.

Mots clés : researchers, night, european, israel

Participants :
- Migal - Galilee Technology Center (Israël) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 20812.0 €
- Sami Shamoon College of Engineering (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20993.0 €
- Tel Aviv University (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 21011.0 €
- Weizmann Institute of Science (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20993.0 €
- Bloomfield Science Museum Jerusalem (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 21154.0 €
- Bar-Ilan University (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 21116.0 €
- Hebrew University of Jerusalem (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 21034.0 €
- University of Haifa (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 27074.0 €
- Technion – Israel Institute of Technology (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 20920.0 €
- Madatech (Israël) — Coordinator, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 41660.0 €
- Israel Oceanographic and Limnological Research (Israël) — Partner, beneficiary, Recherche, subvention : 42118.0 €
- Open University of Israel (Israël) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 21115.0 €
Projet Biased AI (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Following trends to design Artificial Intelligence (AI) for Good, (a plea to develop AI in ways addressing pressing problems that face humanity), the focal question we will address is: What is the proper combination of open and proprietary elements in AI innovation in the field of mental health in light of the need to design a system that both promotes innovation and is compatible with the ideals of human dignity, fundamental rights and freedoms, and cultural diversity? Our concern in the context of mental health in particular is that proprietary AI may reproduce gender and racial stereotypes, which in turn may reinforce social stigma and raise a barrier to proper diagnosis and treatments. On the other hand, the present research does not entertain a model of innovation where the proprietary stands in opposition to the open. Rolling back private property does not necessarily favour the weak over the strong. To this effect, we propose to conduct qualitative research to identify public and commercial demands in order to rethink the governance of innovation in AI, focusing in particular on mental health. Participant observation and Interviews with key stakeholders will be conducted to elicit their views, taking into account not only economic but also ethical aspects (diversity, rights and freedoms). The governance question needs to take into account public demands that are technically feasible and at the same time commercially viable in the AI area.

Mots clés : artificial intelligence, bias, mental health, innovation, intellectual property, bioethics

Participants :
- Ghent University (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172800.0 €
Projet AllergyBLOCK (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Food allergies are chronic diseases of increasing prevalence for which there is no approved treatment other than food allergen avoidance. Among all food allergies, peanut allergy is a particularly important public health problem since peanut allergy tends to persist throughout life and is more likely than other types of food allergies to cause severe shock (i.e., “anaphylaxis”) and death. The current paradigm states that peanut allergy is mostly triggered by IgE antibodies. Evidence derived from mouse models indicates that some IgG isotypes can also mediate allergic reactions, but the roles of human IgG in peanut allergy remain unknown. Among the potential treatments for peanut allergy under investigation, oral immunotherapy (OIT) appears very promising since subjects completing OIT tolerate food challenges despite persistent high-titers of IgE in the blood. OIT consists of the administration of slowly increasing doses of the allergenic food and is associated with the production of large levels of IgG, but a direct link between these antibodies and the beneficial effects of OIT has not been demonstrated. We hypothesize that peanut allergic patients produce both pro-allergic and protective IgG, and that successful OIT is associated with an increased production of protective IgG that are particularly potent at blocking the allergic reaction. We propose to test this hypothesis by developing and exploiting humanized mouse models of peanut allergy, combined with the use of clinical samples and purified IgG from peanut allergic patients completing a phase 2 OIT clinical trial. Finally, we aim at establishing the proof of concept that recombinant protective human IgG could be used to treat peanut allergy and improve the safety and efficiency of current OIT protocols.

Mots clés : food allergy, immunotherapy, immunoglobulin

Participants :
- Institut Pasteur (France) — Partner, beneficiary, Recherche, subvention : 23134.5 €
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 161941.5 €
Projet IPCOS (Horizon 2020, appel à projets 2014)
Action : Doctoral Networks - Industrial Doctorates
Panel : Chemistry
Statut du projet : CLOSED

Food quality is a global key priority area where technological advances in terms of quality control have been limited. The aim of the IPCOS Network is to bring innovation to the field of food quality by offering an international, interdisciplinary and intersectorial doctoral training programme that will target the development of chemical sensors, using the molecular imprinting technology, for application in the coffee industry, focusing on three main targets: chlorogenic acids, cafestol and kaurene terpenes, caffeine and its metabolites, all of which have been shown to have an impact on consumers’ health. This project brings together 2 academic teams, 1 large international company, 1 SME and one non-profit research centre of excellent, supported by 4 associated teams, with a very multidisciplinary and multisectorial expertise. The IPCOS training program will require ESRs to work 50% of their time in industry, providing them with a set of unique scientific and transferable skills that will match both public and private sector needs, together with a strong development of innovation and entrepreneurship ethos, therefore considerably enhancing their career perspectives. All researchers will aim to achieve a doctoral degree at the end of their training. As a result of the close collaborative links, IPCOS will strengthen the innovation capacity of universities/research institutes to commercially exploit their research and enhance the research potential and competitiveness of European companies and SMEs.

Mots clés : chemistry and organic synthesis, polymer synthesis and characterisation, computational modelling and physicochemical characterisation of materials, chemical sensors, biosensors, electrochemistry

Participants :
- Campden BRI (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- T. & b. e associati s.r.l. (Italie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of Trieste (Italie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 516122.64 €
- Biorealis (Slovakia) (Slovaquie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Illycaffe s.p.a (Italie) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- Centre of Excellence for Biosensors, Instrumentation and Process Control (Slovénie) — Partner, beneficiary, Autres, subvention : 0.0 €
- University of Ss. Cyril and Methodius in Trnava (Slovaquie) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 819863.64 €
- International coffee organization (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet FANTASTICAL (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Food safety remains a main concern for consumers, society, health agencies and food industry. Despite the efforts made during the last years, the number of outbreaks and food borne diseases is still high. Recent outbreaks within the European Union (e.g. L. monocytogenes in frozen vegetables) show that efforts are needed to coordinate scientific advances into decision making in order to implement new measures to increase consumer protection. Quantitative Microbial Risk Analysis (QMRA) can be applied to support food safety management. QMRA is based on a mathematical description of the microbial response during the farm-to-fork chain of the product. Its application requires an accurate characterization of uncertainty and variability, inherent to any biological process. Because of these, QMRA must follow a probabilistic approach, considering the variance of the response variables. Consequently, decisions must be made with an acceptable level of risk given the knowledge gaps. A deeper knowledge of both uncertainty and variability is a top priority in the EU, since it would allow a better application of QMRA, leading to a better safety standards for policy makers and industry. FANTASTICAL aims to develop novel approaches and tools for QMRA that can be implemented by all the stakeholders, i.e. agencies related to consumer protection (EFSA, ECDC) and industry. It will link a database of microbial responses with robust statistical functions for variance analysis and stochastic simulation in a user friendly software. This project will reach out to the potential users and provide them with hands-on, open access tools to better understand microbial variability and uncertainty, resulting in more realistic QMRA. Thus, it will lead to an improvement in consumer protection and safer products. It will also complement Dr Garre’s curriculum and provide him with soft skills required to take the next step of his scientific career towards becoming an R3 – Experienced Researcher.

Mots clés : microbial risk assessment, variance analysis, databases, foodborne pathogens, food quality, biological variability, uncertainty, decision support tool

Participants :
- Wageningen University & Research (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175572.48 €
Projet ACQUIRE (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

For many commercial potato cultivars, tuber yield is optimal at average day time temperatures in the range of 14-22˚C. Further rises in ambient temperature can reduce or completely inhibit potato tuber production, with damaging consequences for both producer and consumer. Despite centuries of potato breeding, high temperature tolerance has not been significantly improved. Targeted breeding approaches are hampered by a lack of knowledge on the molecular mechanisms of how plants perceive and translate high temperature into relevant acclimation responses. Although in recent research we have identified genotypes that can yield well under elevated temperatures, we have not yet dissected which responses to elevated temperature are the most critical for yield. Thus the objectives of ACQUIRE are: to develop a robust screen to assay for acquired thermotolerance in potato; to test potato genotypes and transgenic lines for variation in the acquired thermotolerance response; to determine transcriptional and metabolite profiles associated with acquired thermotolerance; to introgress beneficial alleles of a potato heat tolerance gene (StHot1) to develop Nearly Isogenic Lines with improved acquired thermotolerance characteristics; to assess the impact of acquired thermotolerance on tuber yield in a range of genotypes. The project will serve a training vehicle for an experienced researcher to enhance her portfolio of research skills and so increase their ability to innovate in this important area of food security. The experienced worker will add an extra dimension to current research activities in the host organisation by sharing her current expertise. The outcomes will be of commercial and societal interest and a raft of measures will be taken to ensure thorough dissemination of the project activities. The project will leave the experienced worker well-qualified to achieve professional maturity and will have a legacy of collaboration and new research avenues to be explored.

Mots clés : plant physiology, crop genetics, plant breeding

Participants :
- James Hutton Institute (Royaume-Uni) — Coordinator, beneficiary, Recherche, subvention : 183454.8 €
Projet Neuronal MRI (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Functional MRI (fMRI) is currently the leading noninvasive modality to assess brain function in vivo. However, it relies on a surrogate marker for neural activity –the hemodynamic responses following activity– which makes fMRI nonspecific and difficult to interpret. Here, we propose to advance the state-of-the-art by developing and evaluating a methodology we term neuronal fMRI (nMRI) which would enable a direct measurement of neuronal activity and its fast dynamics. Achieving this arduous goal calls for a truly interdisciplinary effort, borrowing concepts from Chemistry (Chemical Exchange Saturation Transfer (CEST) of a neuronal-selective metabolite to impart specificity, restricted diffusion to probe cell sizes), Physics and Engineering (advanced MRI and reconstruction methods). Our general approach consists of a development-validation-application design, thus our main objectives are: 1. Harnessing the hitherto unexplored downfield resonance of N-Acetylaspartate (NAA) –a metabolite confined solely to neurons– in CEST MRI experiments, thus imparting specificity towards the neuronal population; combining this specificity enhancement with diffusion MRI sequences that are extraordinarily sensitive to cellular sizes, and hence are able to sense subtle cell-swellings arising upon neuronal firing. This new method, which we term neuronal-MRI (nMRI) will thus report on neuronal swellings, and as such reflect activity directly. 2. Implementing ultra-fast imaging techniques based on data multiplexing and the latest compressed sensing frameworks to nMRI, such that the 50 ms timescale can be reached with full brain coverage. This will allow the measurement of fast neuronal activity dynamics in the brain. 3. Applying nMRI to study the auditory circuit as a model system in-vivo. In summary, we posit that nMRI –upon successful implementation and rigorous testing– will be highly impactful in many disciplines, and pave the way to study the neuronal population in health and disease.

Mots clés : chemical exchange saturation transfer, n acetyl aspartate, neuronal activity, magnetic resonance, brain dynamics, optogenetics

Participants :
- Champalimaud Foundation (Portugal) — Coordinator, beneficiary, Recherche, subvention : 148635.6 €
Projet ELECTRONANOMEGA (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Functional foods containing omega-3 lipids, which have approved health claims by EFSA, have resulted in one of the fastest-growing food product categories in Europe. However, to successfully develop foods enriched with omega-3 PUFA, lipid oxidation of these highly unsaturated fatty acids must be prevented in order to avoid both the loss of nutritional value and the formation of unpleasant off-flavors. Omega-3 PUFA can be added to foods as neat oils or as a “delivery system” such as microencapsulated oil powders and oil-in-water emulsions. Nevertheless, delivery of omega-3 lipids in the form of emulsions reduces the oxidative stability of omega-3 PUFA in some products. Furthermore, microencapsulates are less suitable for liquid or semi-liquid foods than emulsified omega-3 oils due to handling/mixing issues. Therefore, the development of alternative omega-3 PUFA delivery systems, which are easy to disperse and which will lead to improved oxidative stability of omega-3 enriched food products, is urgently required. One of the more promising delivery systems can be functional nano-microstructures obtained by electrospinning technology, which is possible to up-scale. In light of the above, the aim of this research project is to develop advanced omega-3 delivery systems such as electrospun nano-microstructures. To this end, the specific objectives are: 1) Development of physically and oxidatively stable nano-microstructures with omega-3 PUFA and natural antioxidants using electrospinning processing. 2) Production of food enriched with the nano-microstructures having appropriate structural-functional properties and being oxidatively stable. The success of the research proposed will lead to an important advance in the protection of omega-3 PUFA against oxidation when incorporated into food. Thus, the knowledge generated by this study has the potential to being exploited by companies devoted to the production of functional foods containing omega-3 lipids.

Mots clés : food technology, omega 3 fortification, nano microstructures, electrospinning processing, oxidative stability, physical structure, technological properties, antioxidants evaluation

Participants :
- Technical University of Denmark (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200194.8 €
Projet MINDS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Functional magnetic resonance imaging (fMRI) is the dominating approach to research in the mapping of neural activity in the human brain. State of the art data analysis techniques employ a statistical parametric mapping (SPM) strategy to convert raw signal into interpretable images by processing data in a pipeline of task-specific modules. This approach, despite its simplicity and reliability, presents a set of inconveniences, including low interconnectivity among modules, resulting in suboptimal solutions. In this project we aim at making a major contribution to the field by replacing the step-by-step data processing pipeline by a deep neural network. We hypothesise that this will achieve better solutions by propagating the effects of module-based decisions through the network, jointly optimizing the whole processing pipeline. Moreover, fMRI low temporal resolution will be alleviated by means of a post-processing treatment, where advanced interpolation techniques will be used. We will release a freely accessible software tool that integrates with SPM, supplying an easy-to-use framework including advanced techniques for an automatic multivariate non-linear data analysis. The generated deep network solution will be applied in a multidisciplinary study in neurofeedback, where subjects will learn relaxation strategies guided by fMRI technology. At the end of the project, we expect our tool to become a useful standard practise in the field.

Mots clés : functional magnetic resonance imaging, human brain states, deep neural networks, neurofeedback, data processing pipeline

Participants :
- Technical University of Denmark (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet TWISTM (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : CLOSED

Fundamental properties of 2D materials are dramatically modified when they are brought next to each other to form a vertical heterostructure. Then, the combination of the 2D layers as well as the relative orientation between them ultimately determines the performance of the new hybrid material. This presents tremendous new opportunities for manipulating the behaviour of 2D layered materials and ultimately achieving unprecedented control over their performance when integrated into highly specific functional devices. However, research in this field is in its nascent stage and many exciting phenomena remain to be discovered. The main objective of TWISTM is to unravel the most fundamental properties of unexplored graphene- and transition metal dichalcogenide-based bilayers arising from many-body interactions. Progress here requires of a comprehensive microscopic picture of the fundamental properties of the heterostructures in clear connection to their macroscopic behaviour. TWISTM will tackle this challenge by using local probe techniques (STM and s-SNOM) with sub-nm resolution combined with mesoscopic electron transport measurements on in-house engineered twisted bilayers with accurate misalignment angles. TWISTM comprises three goals: i) to develop and optimize a fabrication method towards the achievement of high-quality twisted bilayers, ii) a multiscale search for collective electronic and optical phenomena arising from the coupling between the layers; iii) A full characterization of the superconducting and magnetic properties as a function of the chosen materials combination and twist angle. Overall the project aims at acquiring fundamental scientific knowledge with potential for technological applications that will be useful in both academia and industry. Furthermore, TWISTM will offer high-quality interdisciplinary training to a young researcher helping her to develop a promising independent scientific research career as well as her own scientific network.

Mots clés : graphene, transition metal dichalcogenides, 2d materials, scanning tunneling microscopy, scanning tunneling spectroscopy, superconductivity, heterostructures, low temperature

Participants :
- Columbia University (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Freie Universität Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 246669.12 €