Projet spaXio (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks - Joint Doctorates
Panel : Life Sciences
Statut du projet : SIGNED

Metastasis, the leading cause of cancer-related deaths, arises from the spread of cancer cells to distant organs, where they compromise normal organ function. Cellular interactions, paracrine factors, and the metabolic environment promote the formation of metastatic niches that facilitate tumour cell survival and proliferation. While single-cell data have improved our understanding of tumours and their heterogeneity, our knowledge of metastatic niches is still very incomplete. In particular, the lack of spatial context makes it difficult to address critical knowledge gaps in metastatic niche biology which limits our progress in the development of targeted therapeutic interventions. The doctoral network spaXio aims to tackle this challenge by training doctoral candidates (DCs) in cutting-edge techniques, including spatially resolved multi-omics, advanced tumoroid modelling, and computational approaches, including bioinformatics and AI-based prediction models. DCs will conduct systemic analyses of metastatic niches across diverse organ systems and tumour types to improve our understanding of metastatic niche formation and uncover novel therapeutic targets. SpaXio provides comprehensive, multidisciplinary training that combines hands-on laboratory experience, computational data integration, and (industry) secondments. Regular cross-disciplinary workshops and seminars boost innovation and collaboration, while transferable skills training encompasses communication, ethical research, open science, entrepreneurship, and sustainability. By partnering with a network of leading European and international academic, clinical, and industrial experts, spaXio ensures that DCs are exposed to diverse research environments and approaches. This fosters their ability to think across borders, advance technologies and integrate multiple large datasets into a complete systemic picture, preparing them to be leaders in cancer research and shape the rapidly evolving field of spatial biology.

Mots clés : spatial biology, metastasis, immune micro environments, digital twins

Participants :
- Phasics (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Deeplife (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 419558.88 €
- Aix-Marseille Université (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 419558.88 €
- Université de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Sumo technologies gmbh (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Protisvalor (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Partner, beneficiary, Recherche, subvention : 376250.88 €
- Akoya biosciences, inc. (Etats-Unis) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université autonome de Madrid (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Molecular devices (austria) gmbh (Autriche) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université technique de Munich (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 387029.76 €
- Université Eberhard Karl de Tübingen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 1161089.28 €
- Institut national de la santé et de la recherche médicale (France) — Partner, beneficiary, Recherche, subvention : 419558.88 €
- Okomera (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Miltenyi Biotec (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Waters gmbh (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- 10x genomics, inc. (Etats-Unis) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Salzbourg (Autriche) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1210171.68 €