Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet EATing more (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Our bodies turn over billions of cells every day to keep us healthy. Old, damaged or excess cells need to be cleared, and professional and non-professional phagocytes engulf cells dying by apoptosis. The efficiency of this process is critical for homeostasis, minimising inflammation, and promoting organ function. Deficiencies in engulfment predispose to autoimmune and inflammatory diseases, and the host lab has shown that mice deficient in molecular components of engulfment exhibit exaggerated inflammatory responses. We hypothesise that apoptotic cell phagocytosis can be boosted via small molecules that target the engulfment machinery, and that this could open new avenues for therapy in specific disease contexts. Here, I propose to perform an unbiased drug screen to identify small molecule candidates that can enhance apoptotic cell uptake – that is, a ‘gain of function’ screen for engulfment. The host lab has recently developed a fluorescence-based engulfment assay to quantitatively measure apoptotic cell uptake. I will develop this assay into a high-throughput screen to test a large library of compounds. I will address the consequences of pharmacologically enhanced engulfment on professional and non-professional phagocytes, and employ state-of-the-art nucleomics and proteomics approaches to explore the cellular targets of these candidate molecules. Finally, I will test whether the administration of small molecule ‘engulfment enhancers’ can be of benefit in inflammatory disease models relevant to human pathology. This proposal uniquely exploits the complementary expertise of the host lab (pathways of apoptotic cell clearance) and myself (inflammation and disease models), while benefitting from the significant resources of the host institute. While the mechanistic complexities of apoptotic cell clearance are just beginning to be deciphered, we anticipate that this study will also provide insight into molecular pathways of apoptotic cell uptake and processing.

Mots clés : apoptotic cell clearance, boosting phagocytosis, efferocytosis, engulfment, functional drug screening, unbiased targeting, high throughput imaging

Participants :
- Vlaams Instituut voor Biotechnologie (Belgique) — Coordinator, beneficiary, Recherche, subvention : 160800.0 €
Projet SilentFACT (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Our knowledge of the mechanisms underlying cancer rapidly evolves. Diagnosis and treatment are improving, but cancer remains an urgent health burden. Whole-genome sequencing of cancers by the International Cancer Genome Consortium reveals that a key driving force in the etiology of cancer is the abnormal expression of chromatin regulators. The SilentFACT project focuses on an essential regulator of chromatin structure, the histone chaperone FACT. Recently identified small molecules disrupt normal FACT functions, and cancer cells stop growing when FACT levels are reduced. This reveals FACT as an anti-cancer target. We will apply potent cutting-edge genomics, quantitative proteomics and biochemical approaches to systematically dissect and validate the functional networks, novel interactors and chromatin targeting mechanisms of FACT. We will then subject the identified major interactors to a small molecule screen targeting FACT in human cancer cells. This will occur during secondments to the chemical biology platform of the Curie Institute in Paris and at an industrial partner. The SilentFACT project supports a Polish chromatin researcher for two years research and training at Munich University. Our timely research, training and communication aims, as well as exchanges with the international research community, will markedly advance the chromatin field, determine how this essential protein complex is involved in cancer and advance the therapeutic potential of FACT- targeted small molecules. SilentFACT will establish a solid basis for drug development, and advance the researcher’s leadership, networking and employability, helping to establish an independent research program at this exciting interface between basic chromatin science and translational medicine.

Mots clés : histone chaperone, centromere, heterochromatin, cancer, yeast

Participants :
- Ludwig-Maximilians-Universität München (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 159460.8 €
Projet Friend2U (Horizon 2020, appel à projets 2014)
Action : European Researchers' Night
Statut du projet : CLOSED

Our mission of exposing the researchers as ordinary people with an extraordinary job to the public at large in Serbia started in 2010. Annual impact assessment reports show that we significantly influenced the perception and knowledge of the general public regarding WHAT the researchers do, but they also showed that there is room for improving the ways of showing WHO the researchers are, by making the personalities and faces of the researchers recognizable to the society, as well as in clarifying WHY they become researchers, i.e. their motivation and inspiration to explain why research matters to society. Therefore, without losing a focus on WHAT, RN 2014-2015 will focus on the questions of WHO and WHY in order to offer a new dimension of perceiving the researchers and offer more answers beyond the WHAT question. Friend2U - Researchers’ Night project aims at bringing the researchers closer to the general public and increasing awareness of the research and innovation activities with a view to supporting the public recognition of researchers, creating understanding of the impact of the researchers' work on our daily life, and encouraging young people to embark on scientific careers. In other words, it aims at increasing mutual understanding, interest and connections, and facilitating a dialogue between the researchers and the general public. In a nutshell, it is about making the researchers friends with the common people i.e. the general public - as closest friends as possible. Friend2U project proposal mixes, blends and unites faces, voices, results and energies of many generations of the researchers in offering the public at large, regardless of their age, education and scientific background, the opportunity to make friends with these researchers. Here, making friends with the researchers is a paradigm of learning more about their science, learning how to appreciate their work and achievement, and above all, about building trust in what friends do and invessuccessful implementation fot eh ation and as such needs to be udnertaken weell before sumemr break.

Mots clés : friendship, faces of science

Participants :
- University of Novi Sad (Serbie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 5000.0 €
- University of Novi Sad (Serbie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 37000.0 €
- Udruzenje naucnih komunikatora (Serbie) — Partner, beneficiary, Autres, subvention : 10000.0 €
- Visoka tehnicka skola strukovnih studija u zrenjaninu (Serbie) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 12000.0 €
- Centar za Promociju Nauke (Serbie) — Partner, beneficiary, Organismes publics (hors enseignement & recherche), subvention : 6000.0 €
- Kreativno Edukativni Centar (Serbie) — Partner, beneficiary, Autres, subvention : 28000.0 €
Projet UWB-IODA SF-PC (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Our project addresses one of the main challenges of the “Digital agenda for Europe”, namely “Broadband: digital oxygen for all”. While this strategy is expected to have a significant social and economic impact, the huge instantaneous frequency band to be processed also leads to strong constraints, beyond the specifications of the state-of-the-art digital circuits. We propose a multidisciplinary approach that takes advantage of the capabilities and complementary aspects of wireless IR-UWB and UWB-over-fiber technologies to design intelligent, robust and high performance indoor wireless systems, for smart factories and perceptive cars. Thus, by associating UWB waveform optimization, cutting edge signal processing techniques and machine learning algorithms, these green low-cost systems should have the capability to jointly transmit high data rates and provide accurate indoor localization and tracking, as well as to recognize human physiological and behavioral patterns, like vital sign monitoring and gesture recognition. The project aims at increasing the safety, security and convenience in Industry 4.0 environments, by multi-humans discrimination/detection, localization and tracking, without the need for them to wear tags or any additional identification equipment. It also aims to contribute to the road safety by preventing the driver drowsiness related accidents and to facilitate the interaction with the perceptive car by hand gesture recognition. The fellowship will be hosted by the Lab-STICC Joint research unit CNRS 6285, which brings together the project supervisors from the University of Brest and ENIB. It will also benefits from an international collaboration with the Memorial University of Canada, and an industrial partnership with the ZF Friedrichshafen AG company.

Mots clés : ultra wide band, radio over fiber, artificial intelligence, sub nyquist signal acquisition, smart factory, perceptive car

Participants :
- Université de Brest (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 184707.84 €
Projet DOMINO (Horizon 2020, appel à projets 2014)
Action : Staff Exchanges
Panel : Information Science and Engineering
Statut du projet : CLOSED

Our project aims to fill the gap between flexible electronic technology and design by developing highly predictive, generic, open-source, design-oriented organic and oxide based TFT compact model libraries, to be integrated in commercial Electron Design Automation (EDA) environments for full large area low cost circuit design for novel applications. These model libraries will be released together with parameter extraction standard templates to assist in the fast transfer between initial prototype device measurements to full product design. Such a facility will open the opportunity for wide flexible electronics design

Mots clés : flexible electronics, organic device modelling, oxide device modelling, thin film transistors, compact device modelling, printed electronics, tcad tools, eda tools

Participants :
- École polytechnique (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 85500.0 €
- Netherlands Organisation for Applied Scientific Research (Pays-Bas) — Partner, beneficiary, Recherche, subvention : 36000.0 €
- Commissariat à l’énergie atomique et aux énergies alternatives (France) — Partner, beneficiary, Recherche, subvention : 31500.0 €
- University of Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 153000.0 €
- Rovira i Virgili University (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 189000.0 €
- Admos gmbh advanced modeling solutions (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 49500.0 €
- Silvaco (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 72000.0 €
- Technische Hochschule Mittelhessen (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 94500.0 €
- Silvaco (France) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 31500.0 €
Projet ALIS (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Our project fits into the narrative movement in scientific literacy but defends a different position with regard to children’s literature in science. We do not see a division between science and literature but rather a fertile convergence between the construction of a storyline and the activity of scientific “problematization”, a process at the heart of scientific learning. We believe that reading certain fictional narratives offers a conductive environment for engaging young children in scientific questioning. The meaning of the fictional narrative arises from the conflict between the elements of fiction and the elements of reality, between what is within the realms of possibility and what reflects the truth. In contrast, it is through fictional events that natural world phenomena can be questioned. Stories invent a “possible world” which forces the reader back to knowledge of the real world in order to understand it. Following Bruner, we attribute an epistemic aim to some fictional narratives. This project seeks to understand how pupils aged 3-11 years get involved in science within and outside school based on the reading of fictional picture books with the aim of giving teachers the means to develop integrated teaching systems (science and literature): to what extent does reading fictional storybooks lead children to test their representations of the animal world, and more specifically metamorphosis? We will work with a body of “realistic fiction”-type children’s storybooks that bring into play the idea of metamorphosis. We will identify the literary sources to which pupils aged between 3-11 years refer spontaneously when they talk about animal transformations. We will analyse the mechanisms which give rise to the children’s questioning about the metamorphosis of animals as well as comprehending the nature and coherence of this questioning with regard to the stories themselves.

Mots clés : early years education, science education, metamorphososis, biology, fictional storybooks

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 146591.1 €
Projet EXPLORATHON 2021 (Horizon 2020, appel à projets 2020)
Action : European Researchers' Night
Statut du projet : CLOSED

Our proposal builds on the success of EXPLORATHON in Scotland from 2014 to date and will deliver a blockbuster edition of the NIGHT across all of Scotland, utilizing both digital events as well as face-to-face events. Our pan-Scotland partnership learned significant lessons in our online only delivery in 2020 which will allow us to reach more audiences, leave a lasting digital legacy and upskill researchers in how to achieve digital as well as traditional engagement. We will engage with audiences in the main urban centres in Scotland as well as in hard to reach audiences in rural areas and geographically isolated communities in the Highlands and Islands. We will use our full expertise of marketing, social media and styles of engagement to mobilise our researchers and train them to engage with the public. We will use a variety of different styles of engagement from comedy to drama, to online and fun hands-on science experiments to enthuse the public about research and researchers. Working with key partners across Scotland we will showcase to secondary and upper primary aged school children the array of research careers that are on offer and bust myths about researchers.

Mots clés : public engagement with research, inspiring young minds, reaching new audiences, innovative, engagement, promoting research careers

Participants :
- University of St Andrews (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 75196.0 €
- Heriot-Watt University (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 29465.0 €
- University of Strathclyde (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 5340.0 €
- University of Glasgow (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 14335.0 €
- University of Aberdeen (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 85270.0 €
Projet FORESIGHT (Horizon 2020, appel à projets 2016)
Action : European Researchers' Night
Statut du projet : CLOSED

Our proposal for ERN 2016-17 is focussed on foresight, exploring alternatives to consider and manage the future with researchers and the public, envisioning new trends of science and technologies and of their impacts on society. Of special concern are the complex problems and challenges that humanity faces: climate change, sustainable energy, food and water supply, ageing and social inclusion, to name but a few of the global trends identified for the next 10-15 years. FORESIGHT will consider how scientists, technologists, policymakers and citizens together will cope with these challenges; it will also look at the public perception of the associated risks and of the scientific capacity to manage them. FORESIGHT aims will thus be twofold: on one hand the project will provide opportunities for direct contact of scientists with the public in open, lively events, promoting trust and providing role models for younger generations. On the other hand, FORESIGHT will identify trends, challenges and barriers related with scientific and technological developments with societal implications that may become relevant in Europe in the near future. This will be pursued through ongoing debate and deliberation with different stakeholders: business, NGOs, youth clubs, makers and the DIY groups, education community, etc. The detailed programme will be developed by a consortium that includes research centres (IBMC, ITQB) and science communication institutions closely connected to universities (science centres of the Ciência Viva National Network, science museums, botanical gardens). Both the research centres and the Ciência Viva network provide extensive dissemination channels that will ensure the engagement of a wide range of stakeholders and publics.

Mots clés : risks, societal challenges, trends in science and technology, public deliberation, non formal education

Participants :
- University of Coimbra (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 23187.5 €
- University of Porto (Portugal) — Partner, beneficiary, Recherche, subvention : 15312.5 €
- Ciência Viva (Portugal) — Coordinator, beneficiary, Autres, subvention : 102000.0 €
- Universidade Nova de Lisboa (Portugal) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 12500.0 €
Projet AFFINITY (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Our theoretical description of natural phenomena is mostly limited to the regime where the interaction among fundamental particles is sufficiently weak, making the understanding of strongly-coupled gauge theories one of the main challenges of current research in theoretical physics. This proposal aims to study the structure of form factors -- important off-shell generalizations of scattering amplitudes of great phenomenological relevance -- in the maximally supersymmetric Yang-Mills theory at all values of the coupling. Importantly, the strong- and finite-coupling regimes are made accessible by the AdS/CFT correspondence and its integrable structure, respectively. The methods required to achieve the goals of this proposal will extend in a non-trivial way the recent beautiful results in the related field of scattering amplitudes. In particular we plan to derive a precise correspondence between form factors and Wilson loops, to exploit this picture to investigate the strong-coupling regime, and to extract finite-coupling predictions for form factors in the spirit of the recent, powerful OPE approach to scattering amplitudes. Finally we will also analyze the properties of form factors under collinear factorization. This proposal includes a detailed program for the dissemination and communication of its results. The former will mostly be based on seminars and posters at major international conferences, while the latter involves a broad spectrum of outreach activities with diverse audiences ranging from primary school pupils to interested adults. In addition, the proposal includes a detailed training program for the researcher, who will be involved in training courses in scientific management and science communication, and will participate in several scientific workshops and conferences. This wide range of complementary activities is distributed in a balanced way over the duration of the fellowship to maximize the benefit for the researcher.

Mots clés : scattering amplitudes, form factors, cft correspondence, integrability, gauge theories, string theory, conformal field theories

Participants :
- University of London (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet Symbol and Stone (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

Our understanding of the rise of megalithic art is contentious and patchy. SYMBOL AND STONE is a comparative study of the megalithic art in Europe in order to analyze and explain how inter-cultural exchange between prehistoric societies (~4500-2500 cal BC) shaped megalithic art, and to theorize and interpret the significance and function of these images. Most of the ~35´000 still existing European megaliths, which include megalithic tombs, standing stones, stone circles, alignments, and megalithic buildings or temples, were constructed during the Neolithic and the Copper Ages and are located in coastal areas. From several hundreds of these megaliths, especially from Brittany, Andalusia, Portugal, Galicia, Catalonia, Sardinia, the Maltese archipelago, Ireland and Scotland are paintings and engravings known, such as as angular designs, curvilinear motifs, circular motifs, waves, zig-zag, spirals, triangles, trees, anthropomorphic figures, boats, animals, house sketches, weapons etc. Some are combined to form complex symbolic systems. Strikingly, identical motifs and symbol groups can be found separated by long distances. Did the megalithic art develop independently in separate regions? Or, are these images the results of an intercultural exchange? If so, how was such a transfer accomplished? What was the significance of these images and what role did they play for the memory and ritual culture of these non-literate societies? These are the main research questions.

Mots clés : megalithic art, megaliths, europe, neolithic and copper age societies

Participants :
- University of Gothenburg (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185857.2 €