Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet EpiAGPs (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

“By 2050 the Earth will need to feed two billion more people. How can we achieve that without overwhelming the planet?” The question, raised back in 2009, demands quick action. Human life depends on plants, which feeds us, our livestock or fulfils our biofuel needs. Thus to feed this growing population, it will be necessary to double agricultural yields without increasing the amount of arable land. A fine knowledge of the fundamental molecular processes that finely regulate plant reproduction, will allow increasing crop productivity and high quality seed production in a sustainable manner by agricultural engineering, safeguarding the increase of arable land usage. EpiAGPs aims to provide new insights into the role of Arabinogalactan Proteins (AGPs), signalling molecules crucial for plant reproduction, and their signalling cascade, along with their modulation of/by epigenetic mechanisms. This will be achieved using a combination of genetic, proteomic and transcriptomic approaches in the plant Arabidopsis thaliana. Arabidopsis is an excellent model to study the reproductive process, as it shares a conserved developmental program with major seed-producing crop plants. EpiAGPs has great potential to contribute to Europe’s excellence and competitiveness in the world, being in line with the European Sustainable Development Program and with the Europes’ 2020 Strategy goals that is optimisation of food production processes and a lower-carbon impact to achieve sustainable growth. The Host laboratory and I will mutually benefit from EpiAGPs; bringing together two different molecular fields of study related with the same developmental process: sexual plant reproduction.

Mots clés : arabinogalactan proteins, histone deacetylase hda19, signalling and epigenetics, plant reproduction, receptors, fertilization, pollen tube guidance, seed set formation, sugar signalling

Participants :
- University of Milan (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 180277.2 €
Projet DSMFACIL (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

“Nearly all growth in retail comes from e-commerce” states E-commerce Europe, as online sales in Europe grew by 13.3% while the growth in total retail sales merely reached 1% in 2015. However, cross-border sales constituted only 10.6% of Europe's total online sales in 2013, despite the European Commission’s (EC’s) estimate of €415 billion annual contribution to European economy from a European Digital Single Market (DSM), which is currently one of the top priorities of the EC. Besides language barriers and differences in legislature across the EU, the EC states that low engagement can be attributed to: 1) high compliance and delivery costs, 2) low consumer trust regarding foreign retailers’ delivery and after-sales support, and 3) low consumer awareness of foreign retailers. The EC has proposed several trade policy measures to facilitate a DSM. Yet, complementary operational business strategies that enable cross-border profitability under aforementioned challenges have not been explored, while trade measures are still under way. This project aims to develop an interdisciplinary modeling and optimization framework in order to study the dynamics of cross-border alliances between retailers for enhanced cross-border customer acquisition, distribution, and after-sales support. This much-needed framework will provide timely and reproducible models, leading to win-win horizontal cross-border alliances that leverage unique strengths of local retailers under high distribution and compliance costs, low cross-border consumer awareness, and consumer concerns on cross-border delivery and after-sales support. To that end, an interdisciplinary research that uses econometrics, economics, systems dynamics, and optimization literatures will be conducted to create models that can be translated into decision support systems. The proposed models will find future applications in banking and travel sectors, as they face similar challenges in their cross-border operations.


Participants :
- Eindhoven University of Technology (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165598.8 €
Projet RADIOGENFF (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

“Radiogenomics” is the study of the genetics of toxicity following radiotherapy. Unintended damage to normal tissues can severely affect up to 5% of patients for years after completion of curative cancer radiotherapy. To date three Genome Wide Association Studies on radiation toxicity in prostate cancer patients have been performed. These studies have identified genetic loci associated with development of radiation-induced toxicity phenotypes in local tissues. To increase the very limited power of each independent study, the three groups are collaborating on a meta-analysis of harmonised toxicity phenotypes (nocturia, urinary frequency, decreased stream and proctitis) and have identified several promising new loci. The proposed activity at the Centre for Cancer Genetic Epidemiology will be fine-scale mapping of these loci identified with the aim of identifying the genetic variants directly responsible for these toxicity phenotypes. The objectives of the proposed research are: 1. For the Researcher to learn advanced genetic epidemiological and fine-mapping skills by participating in team-based analysis of incoming massive, “OncoArray” datasets – which will be analysed at the host institution; 2. Identify and validate additional novel genetic radiation toxicity loci through analysis of specific radiotoxicity SNP-sets on the “Oncoarray” and through additional GWAS meta-analysis; 3. Apply high-level skills, gained in objective 1, to the fine scale mapping of radiation toxicity loci with the aim of to identifying the top genetic causal candidate variants for radiation toxicity; 4. Carry out bioinformatic functional analysis of the top causal candidates to both narrow the candidate list further, and gain understanding of the molecular patho-physiology and genetic mechanisms that mediate the development of radiation-induced toxicity. Knowledge of these will constitute a further step in identifying genetically at-risk groups likely to benefit from personalized radiotherapy.

Mots clés : fine mapping, gwas, stepwise logistic regression, radiotherapy, prostate cancer

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet R4H1819 (Horizon 2020, appel à projets 2018)
Action : European Researchers' Night
Statut du projet : CLOSED

“Researchers for Humanity 2018-2019” will continue the series of events already organized in Romania from 2007, building a strong link between public and research through this important message of relevance: what science and researchers do are useful for daily life, and their life is as everyone’s elses. For one day (or 2 days in some places), the public will have the chance to meet important players from science and education through play, interesting talks and interactive hands-on learning. Overall, the message conveyed will be how science can be used in the benefit of humanity. Based on the outstanding awareness of the European dimension of the event that we created throughout the years, Researchers Night 2018-2019 will confirm as being one of the most important communication event for research and education institutions. The network increased year after year, so that, now, the event itself will be organized in 21 big, medium and small cities from all over Romania. Also, through the platform, we will invite associated events to get enrolled and be supported by us through promotion at the national level. We aim to reach 52000 visitors, over 350 researchers, students and teachers and over 600000 prs to be exposed to the awareness campaign. The logo will assemble with the old one in order to create a link with previous years and awareness of the European and national dimension of the event. Partnerships will be continued at national and local level (also with one of the most important TV stations in Romania). The main novelty of the project will be the component of private research through private companies and NGOs that are implementing various research projects.

Mots clés : science, edufun, hands on, scifun

Participants :
- Target Active Training (Romania) (Roumanie) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 223325.0 €
Projet SUPERS (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

“Superluminous” supernovae are a rare class of transients, with peak luminosities outshining ordinary core-collapse and Type Ia supernovae by factors of 10s-100, and are primarily found in dwarf galaxies. Now a decade after their discovery (and with more than 100 such supernovae reported), the energy sources and progenitors of superluminous supernovae are still a subject of intense debate, requiring either an exotic explosion mechanism (such as a pair-instability explosion) or an additional energy source (a rapidly spinning down magnetar, or interaction with dense circumstellar material). Thus, superluminous supernovae represent a challenge to our understanding both of the deaths of the most massive stars, of star formation and stellar evolution in low-metallicity environments, and of the powering of optical emission in supernovae. To make progress, several complimentary approaches are needed. Detailed studies of individual supernovae, particularly at late times, can reveal key signatures of the underlying energy source. On a larger scale, key properties of the population such as the absolute rates are currently only poorly constrained. Finally, studies of their host galaxy environments carry information about the underlying stellar populations, and therefore the progenitor stars. This action aims to uncover the progenitors and energy sources of superluminous supernovae by targeting each of these areas, utilizing one-of-a-kind data sets from the Palomar Transient Factory, the upcoming Zwicky Transient Facility, and the Hubble Space Telescope.

Mots clés : superluminous supernovae, host galaxies, transient surveys

Participants :
- Stockholm University (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 185857.2 €
Projet EH (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

“Transformational festivals” are popular contemporary platforms for the performance of community arts. These intentional participatory events have become powerful vehicles for transnational cultures motivated to initiate transit from the conditions of late modernity to mindful, humanistic, and ecologically sustainable futures. Held annually in Nevada’s Black Rock Desert and replicated in over 80 events worldwide, Burning Man is widely recognised as a prototype transformational event. And yet, the transformative dynamics of Burning Man are significantly under-researched. This project will correct this paucity though a multi-sited study focussing on Burning Man as a liminal culture and sonorous society. While the ephemeral and polyphonic conditions of this and other transformational event-cultures are obstacles for researchers, an audio-ethnography of Burning Man is designed to evaluate the liminal architecture and transformational logics of this event-centred movement. Developing new understanding of event-sonicity, the fellowship will interrogate this movement occupying the frontiers of change. The ER will develop skills in sound recording, editing and production, with training advancing comprehension of the socio-sonic aesthetics of Burning Man events. Throughout the project, the ER will undertake fieldwork across two signature projects at three unique field sites, and in addition to this audiography, will co-edit with the adviser a journal special issue, produce two journal articles, publish two industry articles, present at two conferences, organise a symposium, and host two industry roundtables. Training in teaching, research and academic administration will provide a career development plan preparing the ER for a permanent academic post. The project will be integral to the consolidation of festive studies, sound studies and event-culture research as connected interdisciplinary fields of research in which the ER and adviser have each made notable contributions.

Mots clés : festival, event, subculture, transformation, ritual, sonic culture, audiography

Participants :
- University of Huddersfield (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet HYPOXFLU (Horizon 2020, appel à projets 2014)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains. We propose to investigate a copper-mediated fluorination of alkyl boronic species using [18F]fluoride. The value of this new radiochemistry will be challenged with the synthesis and the labelling of two well-known and promising biomarkers for hypoxia, EF3 and EF5. We propose to develop an automated protocol for the production of their radiolabelled counterparts, and to perform a pre-clinical comparative study of [18F]EF3 and [18F]EF5 with [18F]FMISO, the current hypoxia biomarker used for PET imaging.

Mots clés : fluorine chemistry, 18f radiochemistry, biomarkers

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195454.8 €
Projet MAMFRHE (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Physics
Statut du projet : SIGNED

The full rheological response of magnetorheological (MR) fluids will be investigated under unsteady multiaxial magnetic fields for the first time. Such fields are able to drive the MR fluid to minimum energetic states. Thus, we hypothesize that the superposition of multiaxial fields will constitute a relatively easy and straightforward mechanism to optimize MR fluid performance (contrary to current optimization routes, mainly based on complex schemes to tailor MR fluid constituents). The project will assess the MR fluid behavior in both pre-yield and post-yield regimes. In the two cases, bulk rheological properties (viscoelastic moduli, viscosity and normal stresses) will be investigated in terms of the particle microscale structure and dynamics, formation of percolating particle networks at rest or (expected) lamellar structures under steady flow. To do so, the problem will be tackled firstly from a numerical point of view at the Partner Organization. MR fluids will be modelled implementing direct contact forces between particles, hydrodynamics and unsteady magnetic multiaxial interactions using Molecular and Stokesian Dynamics. Secondly, the results from these computational studies will be corroborated through experiments at the Hosting Institution using a custom-built high-speed confocal magneto-rheomicroscope. This consists of a high-speed confocal rheomicroscope coupled to a unique magnetic field generator that allows, at the same time, visual access to the sample and the generation of unsteady multiaxial fields. With this novel and comprehensive project, it is intended to open a new branch in the magnetorheology research field, testing the ability of multiaxial fields to improve MR performance and promote their exploitation in novel or current applications.

Mots clés : magnetic colloids, rheology, experimental colloidal physics

Participants :
- University of Granada (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 245732.16 €
- City University of New York (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PATGOV (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The functioning of the European patent system has been called into question from many different angles. The criticisms range from discontent with low patent quality and with backlogs in patent examination to ethical concerns about ‘patents-on-life’, and from accountability/legitimacy problems of the European Patent Office (EPO) to fundamental doubt about whether patenting fits the current research and innovation models, especially in emerging technologies such as for example biotechnology. The current European patent system is however a rather closed system (that primarily services patent applicants) and it is not inclined to take on board such criticisms and/or considerations that are relevant to society at large. Put differently: the system is currently not aligned with the main principles of Responsible Research and Innovation (RRI). Research in this field seems however to be stuck in –very similar- diagnoses of what is wrong with the system. The project takes the analysis an important step further by looking at changes needed in the governance of the European patent system in order to substantially enhance its responsiveness to societal stakeholders. It tries to explain the limited actual use of inclusive mechanisms that are currently available in the European patent system. It assesses similar mechanisms that are used by other regional patent systems and could potentially be transferred to the European patent system. It looks at changes needed in the institutional set-up of the European patent system in order to enhance responsiveness. The project also analyses changes needed in European patent law that could open up the patent system to more inclusive IP rights, and it addresses the likely impact the new EU Unitary Patent will have on the responsiveness of the European patent system.

Mots clés : european patent system, public sector reform, governance

Participants :
- OsloMet – Oslo Metropolitan University (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 208400.4 €
Projet MINIMAL (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The global market will increase from $11 billion in 2012 to $22.5 billion in 2018 for micro electro mechanical systems (MEMS), and from $1.9 billion in 2012 to $6.6 billion in 2018 for BioMEMS. Recently, metallic nanolaminates have attracted application as mechanical parts in MEMS and BioMEMS manufacturing. This is due to their superior properties, i.e. large flow strength, high indentation hardness, excellent ductility, good radiation damage resistance, qualified electrical/magnetic response, and promising fatigue/failure resistance. In order to address the performance of metallic nanolaminates and to reduce materials’ failure and cost under different service conditions, better analysis/predictive tools are required for dislocation-interface interactions. The improved analysis/predictive tools will allow designing more advanced nanolaminate materials. However, to develop such analysis/predictive tools, it entails (a) in-depth understanding of the physical mechanisms behind dislocation-interface interactions, (b) accurate in-situ mechanical testing data at different length scales from micro- to nanometers, and (c) efficient numerical modelling to predict dislocation-interface interactions. Through this Marie Skłodowska-Curie action, we will contribute significantly towards improving these analysis/predictive tools from two aspects, including (i) providing the scientific knowledge behind dislocation-interface interactions, and (ii) establishing improved numerical models to predict dislocation-interface failure during service. Meanwhile, the new advanced nanolaminate materials with enhanced properties will also be proposed based on the generated knowledge. In addition, the researcher and the host organization will benefit from the two-way transfer of knowledge between them.

Mots clés : characterization, modelling, dislocation interface, nanolaminates, in situ mechanical testing

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 85060.8 €
Projet EMERGE (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The goal of EMERGE is to create new types of two-dimensional materials of the highest quality, and exploit new types of quantum phenomena that emerge in the lower dimensional limit. By combining ultra-high purity fabrication of 2D materials with a high level of control, with high precision spectroscopy, we aim at being able to tailor the phase of these materials with atomic precision. Since the discovery of graphene, there has been an ongoing search for new Dirac materials which exhibit exotic electronic behavior in the two-dimensional limit, in which the spin and electronic degrees of freedom can be manipulated. Toward this end, the family of transition metal dichalcogenides (TMDCs) is extremely promising, as this family of materials exhibits semiconducting behavior, novel spin transport, charge ordering, and superconductivity, when simply selecting the transition metal ion and the interface. However, the role of the environment and how this determines the quantum phases of these materials is still not well understood, and moreover there are still many of these materials which have not been realized. The objective here will be to fabricate and tune TMDCs at the 2D limit, to realize new types of TMDCs, in order to realize exotic phases of matter to unravel the role of the environment and material in creating and discovering new types of quantum phases of matter in these materials. Our goals will be accomplished by combining CVD fabrication of TMDC single layers in ultra-high vacuum, with in-situ characterization of these films with cutting edge spin-polarized scanning tunneling microscopy at ultra-low temperature and high magnetic fields, and angular resolved photoemission in order to fully understand the electronic properties of our materials.

Mots clés : dirac materials, arpes, transition metal dichalcogenides, superconductivity, emergence

Participants :
- Radboud University Nijmegen (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €