Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet Hephaestus (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Accidental ignition of liquid fuels is a critical safety and economic concern for the chemical, aerospace, automotive, and petroleum industries. A fundamental understanding of ignition processes is crucial to reduce accidents and exacerbated pollution emissions through safer and more optimized designs. Even though hot surface ignition is a well-recognized hazard, it is only superficially understood, and safety guidelines tend to oversimplify the phenomenon. Hephaestus project is born from the will of two recognized research centers to merge their expertise to address this issue: the von Karman Institute for Fluid Dynamics (VKI) in Belgium and the Explosion Dynamics Laboratory (EDL) of the California Institute of Technology (Caltech), USA.  Hephaestus aims at improving the knowledge on the ignition processes of a jet impinging a hot surface. A world unique experimental setup will be designed to provide an in-depth optical investigation of the fuel jet ignition. An experimental database will be generated, analyzed, and diffused into the scientific and safety community. The data will be first used to test the existing numerical models. It will be extensively analyzed to detail the different ignition mechanisms. Finally, it will be applied to test engineering models and propose new safety guidelines.  VKI is developing a new laboratory on the use of flammable liquid gas for propulsion. The knowledge acquired during the project's first stage about experimental analysis of ignition mechanisms will be used to support the development of this new leading-edge laboratory. An existing VKI setup will be adapted for ignition characterization by implementing the newly learned experimental technique, and the experimental protocol will be optimized.  Hephaestus project will improve safety via an enhancement of the ignition processes understanding and the diffusion of a fundamental scientific database to be used for future research.

Mots clés : combustion ignition experimental design safety

Participants :
- Institut von karman de dynamique des fluides (Belgique) — Coordinator, beneficiary, Recherche, subvention : 266684.16 €
- Institut de technologie de Californie (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Eprom (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Promoters and enhancers regulate transcription in higher eukaryotes. The classical definition of enhancers is the property to activate gene expression distally, while promoters induce local gene expression. However, itPromoters and enhancers regulate transcription in higher eukaryotes. The classical definition of enhancers is the property to activate gene expression distally, while promoters induce local gene expression. However, it was demonstrated that a subset of promoters, termed Epromoters, also work as bona fide enhancers and regulate distal gene expression. Moreover, it was shown that human single nucleotide polymorphisms (SNP) within Epromoters can influence their function, and consequently distal and proximal gene expression of their target genes. We hypothesise that Epromoters might have an unanticipated key role in coordinating gene expression in disease as well. In this project, I will develop a dual reporter assay to investigate the enhancer versus promoter function of candidate regions, in order to identify novel Epromoters. Subsequently, selecting candidate Epromoters predicted by a previously developed bioinformatics pipeline, I will use the reporter assay to test the candidates in a high-throughput manner. Moreover, I will select those validated Epromoters that contain human disease associated SNPs using genome-wide association studies databases. Next, to determine which of these disease-associated SNPs have an impact on gene expression through Epromoter function, distally regulated genes will be inferred by genome editing of the identified SNPs in relevant cell lines. Concluding, I will study the biology of Epromoters by i) analysing their function in physiological context, ii) assessing the impact of overlapping genetic variants, and iii) determining the effect of disease-associated SNPs on Epromoters and their target gene expression, thus providing a valuable resource to understand Epromoters and their potential involvement in different diseases.

Mots clés : enhancer, promoter, epigenetics, gwas

Participants :
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet TEMP-MOMO (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Europe emerges as a major climate warming hotspot. The temperature rise in the region has occurred at a rate faster than any other continent in recent decades, with 2020 being the warmest year on record at more than 1.6°C above the period between 1981 and 2010. Such a change in temperature has serious implications for health, wellbeing and quality of life of the European populations, as warmer conditions are expected to contribute to an increase (decrease) in heat-related (cold-related) burden of disease (morbidity and mortality). However, there is still insufficient understanding of the impacts of climate change on human health throughout the European Union, particularly at local level, and this gap in knowledge continues to hinder adaptation efforts of the local and regional authorities (LRA). The purpose of TEMP-MOMO is to assess the recent evolution in morbidity and mortality risk and burden associated with ambient temperatures and its main demographic and socioeconomic drivers in France and Spain, using a multi-scale spatial analysis approach. Towards this aim, TEMP-MOMO will generate a massive database with daily counts of death and hospital admissions, together with the best available climate, demographic and socioeconomic datasets. The project will greatly contribute to the EU Mission on Adaptation to Climate Change by addressing knowledge gaps and providing customised data and tools that help decision makers to take informed decisions at all levels of governance from local to country level to protect human health. Specifically, by the end of the project all the local administrative units (LAU) and regions (NUTS) in France and Spain will have easy access to data and climate risk profiles through an interactive mapping tool, the “Temperature and Health Vulnerability Atlas”, to better prepare for climate change related shocks and disruptions.

Mots clés : climate change, temperature, morbidity, mortality, adaptation, demographic and socioeconomic factors

Participants :
- CERCA Institution (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet IEJCGRMI (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The research project focuses on issues of musical socialisation, cultural assimilation, financial strategies and gender inequalities within the jazz scenes of three major European cities: Barcelona, Budapest and Manchester. These three cities are illustrative of fundamental changes in the way that contemporary music scenes in Europe are responding to challenges of globalisation and cultural assimilation. This is most apparent in the many hybrid musical forms being developed by Europe’s traditional (Gypsies) and current (immigrant diasporas) ‘quintessential others’ to express cultural identities. Given that each selected scene’s functioning is closely linked to peculiar ethnic and racial characteristics, the three scenes provide compelling examples of the way in which jazz-related cultural practices reflect, shape and reinvent Europe’s cultural landscape. This interdisciplinary research project of transnational comparative scope is expected to generate new knowledge on the contemporary musical expressions of cultural diversity and assimilation strategies through music in Europe, which is essential to design projects that enhance intercultural dialogue. The following questions will guide the project: How do musicians construct the trajectory of their musical (dis)tastes and how it relates to their socioeconomic status? How does improvised music function to achieve cultural assimilation and (at the same time) to maintain distinctions linked to ethnicity, race and gender? How does gender become a relevant factor in acquiring prestige? What types of economic and artistic strategies do musicians develop to achieve artistic autonomy? Throughout the fellowship, the ER will conduct 35 in-depth interviews with mixed-background jazz musicians, undertake ethnographic fieldwork at eight venues, submit two articles, present at five conferences, organize academic workshops and design an international series of popular science events to further disseminate the results.

Mots clés : jazz diasporas, transnational distinctions, hybridity, cultural diversity, cultural difference, musical socialisation, multi ethnic relations, assimilation, 

Participants :
- Université de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet tR-GET HD (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Many pathogenic mechanisms are involved in Huntington’s disease (HD), the most prevalent monogenic neurological disease in Europe, with no current cure. The host team reported a dysregulation of tRNA-fragments (tRFs) in HD brains; other studies showed higher stress granules' (SG) density in HD, and that tRFs promote SG assembly. Thus, my hypothesis is that HD-related tRFs contribute to the accumulation of SG, initiating mutant huntingtin (mtHTT) aggregation and leading to disease pathogenesis. I propose to explore the interaction between mtHTT aggregates, and tRFs and SG, as new potential therapeutic targets. Specifically, I aim to study the 1) cell-type specificity of tRFs formation and their correlation with HD progression; 2) molecular mechanisms by which tRFs may induce HD pathology; and 3) potential of tRFs modulators to treat mtHTT-related neurotoxicity. This project’s success relies on the perfect synergy of the host team’s expertise in tRFs biology and HD and my own experience in RNA and proteotoxicity in neurodegenerative diseases, thoroughly addressing the hypothesis via complementary human, cellular and mice HD models and a plural array of bioinformatic, molecular biology and genomic approaches. The outcomes will help define the role of tRFs and SG in mtHTT aggregation, and may be used as preclinical proof-of-concept for novel HD therapies, reflecting the project’s translational potential. I will benefit from scientific exchanges with expert neuroscientists in the host institution, particularly my supervisor, whose skills in functional genomics fully match my expertise in RNA and protein pathological mechanisms. My translational technical knowledge and network of collaborators will be useful to the host group to build new cooperative projects. Thus, the MSCA fellowships will allow me to develop unique technical and transferable skills, helping me progress and establish myself as a leader in neurodegenerative research within a European research institute.

Mots clés : huntington s disease, trna, trna derived fragments trfs , stress granules, huntingtin protein aggregation, neurotoxicity, pathogenic mechanisms, therapeutic potential, protein translation

Participants :
- Université de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188121.81 €
Projet SUSTAIN (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Cities across Europe are facing a surplus of vacant properties, while the housing shortage is reaching a critical threshold. Adaptive Reuse (AR) practices are emerging as a convincing approach to address the challenges of escalating housing demands, while facilitating the transition towards a circular economy. Recently, municipal programs have emerged across the EU to address the housing crisis by extending regulatory flexibility to ease the provision of affordable housing through AR of unused buildings. As these programs are still in their early development stage, a body of theoretical knowledge or evidence-based guidance in this domain is absent. The lack of standardized frameworks hampers a comprehensive evaluation of the impacts of projects of Adaptive REuse for Affordable Housing (AREAHs), and no research has been undertaken to determine the extent to which these may contribute to changes in the social and environmental well-being of neighborhoods. More study is also required to evaluate the role of existing regulatory frameworks in hindering or facilitating the implementation of AREAHs. SUSTAIN will answer these questions through a comparative analysis of AREAHs in 5 EU cities, so as to: RO1) Assess their housing impact and environmental enhancement value—through a quantitative analysis of selected performance indicators; RO2) Identify regulatory roadblocks and/or trailblazing policy instruments that facilitate AREAHs—through in-depth interviews with experts and discourse analysis of municipal policies; RO3) Assess AREAHs’ long-term contribution to neighborhood reactivation—through a longitudinal neighborhood data analysis. In a context in which municipalities strive to tackle the housing crisis while minimizing their carbon footprints, it is timely and urgent to assess the impact of AREAHs, evaluating wins and drawbacks. SUSTAIN will provide an evidence base on AREAHs across the EU and reflect on what steps might be taken to expand their scope of activity.

Mots clés : adaptive reuse, housing, affordable housing, social housing, housing policy, environmental planning, circular economy, retrofit, urban planning, urban policy, regeneration

Participants :
- Université de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €
Projet mirADAM (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : TERMINATED

ADAM10 (A Disintegrin and Metalloprotease 10), the main α-secretase of the non-amyloidogenic cleavage of the amyloid precursor protein (APP), is a common player in Type 2 diabetes (T2D) and Alzheimer´s disease (AD). ADAM10 levels are altered in platelets, plasma, serum, and CSF of elderly with AD, suggesting its potential role as an AD biomarker. It is well known that there is an association between impaired insulin signaling and the amyloid cascade, as ADAM10 is also increased in T2D and insulin increases the expression and activity of this protease. However, few studies present efforts to understand the regulation of miRNAs ADAM10-targeted in these diseases, and its application on electrochemical sensors. This proposal aims to explore and validate circulating miRNAs that are deregulated, directly related to the pathophysiology of AD, T2D, or AD+T2D, and are ADAM10-targeted, as well as to assess the value of specific miRNAs panels on the diagnosis and prognosis of AD, leading to the application of these findings on a diagnostic device. All ethical aspects involved will be respected. Frozen serum samples will be provided from biorepositories and by a biobank. RT-qPCR assays will be performed for serum miRNAs screening differentially expressed in healthy control, T2D, AD, and T2D+AD subjects. Then, miRNA cross-sectional validation studies will be designed, and the capability of accurately detecting these miRNAs in a microfluidic platform will be tested. Data analysis will be conducted through ANCOVA, conditional logistic regression, and panels of ROC curves. This proposal attempts to provide evidence regarding the role of ADAM10 as a relevant link between two diseases of pandemic proportions, whilst identifying specific blood miRNAs ADAM10-targeted with diagnostic and prognostic potential to AD, leading to the application of these findings on a diagnostic device, highlighting its advantages as a less invasive, easier, faster, and lower-cost proceeding.

Mots clés : micro rnas adam10 biosensors

Participants :
- Université de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 90576.48 €
Projet In-Music (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

While music is undoubtedly a primary expression of any civilization, Western society seems to have moved further and further away from the music of its past, thus missing a great wealth of its own identity. Rethinking how we approach historical music is essential to bridge this gap and IN-MUSIC intends to make an innovative contribution in this direction. The project will focus on a particularly interesting yet little-addressed branch of cultural heritage, music iconography, addressing it through a multidisciplinary approach that combines iconological methodology with the application of digital technologies. Due to the very nature of music iconography, digital technologies represent a tool with enormous potential for both its study and enhancement. In fact, only in a virtual context is it possible to reconstruct the original ideal multi-sensory nature of musical images while digital means allow the socialization of highly specialized music-related contents in a dynamic and engaging way. Nonetheless, little has been done to fully explore this potential, especially in terms of interactivity. IN-MUSIC will address Early Modern Spain music iconography and will delve into different digital approaches and communication strategies, in order to devise replicable and versatile instruments. A semantic database, based on CIDOC-CRM, and a set of prototypes of digital devices will be elaborated, resorting to the use of different open-source software. All the prototypes will be submitted to different targets of public who will be asked to fill out a specifically designed survey to collect useful data for the evaluation of the effectiveness of such tools in communicating knowledge. The success of the action will therefore increase our knowledge on Spanish musical imaginary in a crucial historic context while providing scholars and cultural stakeholders with efficient means to study, teaching, and enhance an unconventional heritage.

Mots clés : music iconography digital humanities digital heritage music iconology interactivity museology heritage communication virtual technologies

Participants :
- Université de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet redOXFluxMAP (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The skin is the widest organ of the human body. Despite this, the mechanisms that underline its regulation are relatively poorly understood. Many skin diseases are characterized by defects in the control of lining renewal or reestablishing barrier integrity after the disruption. Thus, dissecting the signals that underpin the maintenance of skin homeostasis and regeneration are of pivotal interest for medicine. Recently, redox signaling as described to have a crucial role in these processes: indeed, H2O2 -the major signaling molecule of redox biology- is not only an essential second messenger, involved in skin proliferative and survival pathways but also it is reported that mild ER stress cursing with an increase in organelle redox potential is needed for efficient reepithelization. Recently, we have shown the presence of different ER-linked H2O2 fluxes that orchestrate cellular redox responses in normal conditions and after the induction of ER stress in HeLa cell lines. In this scenario, I propose to unveil the compartment-specific H2O2 fluxes that regulate the redoxstasis during keratinocytes differentiation with particular emphasis on those that arrive from the Endoplasmic Reticulum (ER). Indeed, the ER is one of the major contributors to cellular redoxstasis harboring sources, internal regulators, and distributors that vehicle redox signals back and forth to the ER. In particular, I divide this project into two main aims I) Characterize the role of intracellular redox fluxes during keratinocytes differentiation both in 2D and in 3D models II) Identify the interactors of ER-derived H2O2 flux in skin cell lines and characterize the downstream pathways. Importantly, a systematic analysis of the timing, thresholds, and targets of redox signals in skin pathways is a paramount gap in the field that has not yet been tackled, and thus constitutes the principal aim that this project wants to undertake.

Mots clés : skin, redox signaling, h2o2, flux, differentiation

Participants :
- Université Charles-III de Madrid (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet MAP-STROKE (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Stroke is a leading and increasingly important cause of death and disability in the EU. Yet, we have only few effective treatments and an unsatisfactory understanding of human stroke pathophysiology. Current diagnostic algorithms fail to capture pathophysiological mechanisms in daily clinical practice, hindering the allocation of patients to treatments and the development of novel therapies. While stroke care algorithms rely on clinical and single-timed imaging assessments, thousands of proteins and metabolites circulate within the blood representing a neglected window into our body. With MAP-STROKE, I aim to leverage serial multi-omics, longitudinal imaging, and deep clinical phenotyping data from the recently completed PROMISE study (N>500) to create a molecular map of human ischemic stroke and to identify novel clinically meaningful molecular biomarkers. By combining multiple unique project features including i) a novel molecular conceptualization of stroke, ii) the integration of genomic, proteomic and metabolomic data, iii) high-frequency serial assessments, iv) longitudinal imaging and phenotyping, and v) novel bioinformatics methodology including multi-omic factor analysis, MAP-STROKE goes considerably beyond the current state-of-the art and will advance personalized medicine in stroke. The MSCA fellowship under the mentorship of Dr. Steffen Tiedt at the Institute for Stroke and Dementia Research at LMU Munich would give me the exceptional opportunity to apply and expand my bioinformatics expertise in molecular modeling towards more complex multimodal biomedical data and to develop the skillset needed to become an expert and eventually independent group leader in medical bioinformatics in Europe. I envision the identified molecular biomarkers to drive precision medicine in stroke and to reduce its societal and economical burden.

Mots clés : stroke, muti omics, molecular map, proteomics, metabolomics

Participants :
- Université Louis-et-Maximilien de Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202125.12 €