Projet HOTBIO (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

The HOTBIO consortium will train a new generation of early-stage scientists to take marine microbial natural products from the seabed to the bedside. They will be involved in every stage of the pipeline from microbial isolation through compound purification and identification to making analogues with desirable drug-like properties. They will gain associated skills in access and benefit sharing, intellectual property and entrepreneurship. Students graduating from HOTBIO will be in a unique position to enter a challenging labour market as they will have received multidisciplinary training at world leading research groups in academia as well as at industry partners. Mentorship will be provided by industrial scientists and recent graduates from the MSCA ITN MarPipe.  The HOTBIO consortium consists of eight beneficiaries from seven European countries, including two members from non-academic sectors, that will host ten PhD students. Three more PhD students hosted by two Swiss associated partners will be funded by the Swiss State Secretariat for Education, Research and Innovation. In addition to secondments at the partners in Europe, students will also get the opportunity to do secondments in low-to-middle income countries (LMICs) in Africa and Asia to get a deeper understanding of how modern research can be done in resource-limited setting.  HOTBIO expands a conventional marine biodiscovery pipeline by including computer aided drug design (CADD), chemical synthesis of optimized compounds (i.e. medicinal chemistry), target deconvolution and extensive ADMET profiling. This will advance the bioactive microbial secondary metabolites to the later stages of preclinical development, and it will also inform the decisions and priorities of what kind of compounds that should be targeted in the initial phase of the drug discovery process. The downstream development will include hit compounds from earlier projects.

Mots clés : secondary metabolites, marine microbes, marine biodiscovery, drug discovery, bioactivity, preclinical development, genome mining, dereplication, structure elucidation, chemical synthesis, cadd

Participants :
- GEOMAR Helmholtz Centre for Ocean Research Kiel (Allemagne) — Partner, beneficiary, Recherche, subvention : 260539.2 €
- Abs-international (Belgique) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 525240.0 €
- Université de Grenade (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- KU Leuven (Belgique) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Fundación Medina (Espagne) — Partner, beneficiary, Recherche, subvention : 251971.2 €
- Université d'Aberdeen (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Messine (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université du Ghana (Ghana) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Nicolas-Copernic (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 226512.0 €
- Bacto - tech sp. z o.o. (Pologne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Stazione Zoologica Anton Dohrn (Italie) — Partner, beneficiary, Recherche, subvention : 259437.6 €
- Université de Lausanne (Suisse) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Lead Discovery Center (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €
- Université de Tromsø (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 595497.6 €
- Université Christian Albrecht de Kiel (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de la Ruhr à Bochum (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €