Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet DNAGAM (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Programming the autonomous and multiscale structuring of shapeless synthetic soft matter is unknown and conceptually challenging. In stark contrast, a living embryo is highly ordered at all levels – from cells to the entire organism. The ordering is a multistep process, starting from the patterning of biomolecules (morphogens) which later instruct autonomous shape transformations (morphogenesis). Inspired by these natural physicochemical processes, we aim at the preparation of a first-ever synthetic biocompatible material which can be self-organized in a programmable and autonomous manner. The programming will be achieved by an out-of-equilibrium DNA-based chemical network which predictably generates single-stranded DNA morphogens. Combined with diffusion, the concentrations of the morphogen can be patterned with a unique spatiotemporal precision, including travelling waves and stable fronts, which were pioneered by the host group. The autonomy of morphological structuring will be accomplished by linking the mechanical activity of active gels, composed of DNA-kinesins and microtubules, to the presence of the DNA morphogen. Latter will act as a cross-linker creating the clusters of kinesins and thus guiding the self-organization of the soft material by the collective action of nanoscale kinesin motor proteins which exert force on microtubules. Apart from the preparation of a first biocompatible man-made morphogenetic material, we will learn how the self-organization of active gels is dependent on morphogens’ patterns. This knowledge is indispensable for the advanced programming of the precise macroscale shapes at the molecular level of chemical networks, which are diverse and modular. With further developments, our methodology could lead to so far elusive self-fabricated, force-exerting synthetic soft matter with the potential of integration in soft robotics and biological environments.

Mots clés : active matter, dna nanotechnology, morphogenesis, soft materials, out of equilibrium systems

Participants :
- University of Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 73765.44 €
- Sorbonne Université (France) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 122942.4 €
Projet EPICNIGHT (Horizon 2020, appel à projets 2014)
Action : European Researchers' Night
Statut du projet : CLOSED

Researchers’ Night again in Poznan! EPICNight! Enthusiasm, Passion, Inspiration, Challenge– join us during the Researchers’ Night and see for yourself how by connecting science and passion one can make a difference! Come and uncover the secrets of scientists and researchers! Open the doors to your good neighbours – researchers! Measure immeasurable and see invisible! Become a researcher for one night and construct DNA helix, have a ride in 3D helmet, design your own clothes or learn the secrets of Eco-robots! Come and sing karaoke songs with researchers and at the end dress up like a famous scientist and dance with us cha-cha or jive. Feel like doing some sport? These and many other attractions are waiting for you to reveal your passion for science and convince you that researchers are just ordinary people with an extraordinary job and various hobbies! EPICNIGHT is a continuation of the Researchers’ Night projects of the past seven years, which were highly successful gathering last year app. 57 000 people willing to meet researchers face to face and to learn new things about their work and personal lives. The project, promoting an image of researchers, builds on last years’ experiences and aims at enhancing further public recognition of researchers and their work by bringing them closer to the public, underlying their important contribution to the daily life and well-being of the European citizens. Activities organised during the Night on 26 September 2014 and 26 September 2015 will be focused on public at large and will have even more hassle-free and festive character, being a valid alternative to "traditional Friday night activities" while allowing learning more about researchers and research. Those activities will offer a direct contact between researchers and public, combine fun and education elements (edutainment), ensure linking together Nights organised in different cities in Poland and ensure an active and direct involvement of the visitors in activities.

Mots clés : epicnight, researchers, poland, poznan, edutainment

Participants :
- Polish Academy of Sciences (Pologne) — Partner, beneficiary, Autres, subvention : 18825.0 €
- Poznań University of Economics and Business (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 9900.0 €
- Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 9900.0 €
- Poznań University of Technology (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 49800.0 €
- University of Life Sciences in Poznań (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 24950.0 €
- Adam Mickiewicz University in Poznań (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 19400.0 €
Projet UNIGHTED (Horizon 2020, appel à projets 2018)
Action : European Researchers' Night
Statut du projet : CLOSED

Researchers’ Night in Poznan is back! UNIGHTED is “United Europe – United Science – United Culture – United Night”! The project is a unique undertaking of science united, an opportunity to see in action scientists from different fields working together. Discover the interdisciplinary character of science, check out how various areas of science complement each other to make our life better. Take part in an innovative interdisciplinary event “Where sciences converge” and observe how scientists in various areas of science collaborate for the common good. Have a glance into research laboratories and see up close the nature of researchers’ work; observe how robots help in telemedicine, enter FutureSmartSpace and see how new technologies influence interpersonal relationships; carry out experiments in a biotechnology laboratory; uncover the mysteries of meteorites, join in dance and sports. Find out that people of science are ordinary people and their work is simply fascinating. In the context of “United Europe – United Science – United Culture” learn how common European heritage has been influencing a variety of sciences, and how researchers have been working for the common good of entire Europe. And all that thanks to science presented in a fun and straightforward way (edutainment). The UNIGHTED project contains a continuation of projects from previous 11 editions as well as many new ideas. Year after year more participants are attracted to Researchers’ Night as new generations grow up, interested in science and people of science. Every year new venues are opened and programmes are enlarged in order to accept all those interested. This year’s project aims to build on the previous ones and to shed light on novel aspects of science: its interdisciplinary character, common research work for Europe and Europeans. Researchers’ Night both in 2018 and 2019 shall be a great celebration of science, a family fun as well as an alternative to traditional Friday night activities.

Mots clés : researchers  night, unighted, united europe, united science, united culture, united night, wielkopolska region, poznan

Participants :
- Polish Academy of Sciences (Pologne) — Partner, beneficiary, Recherche, subvention : 19625.0 €
- Adam Mickiewicz University in Poznań (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 26712.5 €
- University of Life Sciences in Poznań (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 25940.0 €
- Poznań University of Technology (Pologne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 52050.0 €
- Poznań University of Economics and Business (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 11170.0 €
- Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu (Pologne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 8002.5 €
Projet ROSETTA (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Resistance and cancer progression remain a major obstacle to the successful treatment of cancer. In HER2+ breast cancer, the development of targeted therapies such as trastuzumab, has revolutionized the treatment for these cancer patients. However, a significant number of patients develop resistance. In this realm, my previous work focused on understanding the crosstalk of interconnected signaling pathways in HER2+ cancer cells that drive tumorigenesis and undermine the efficacy of current treatments. The research goal of this proposal is to provide a new focus to the challenge of resistance by deciphering the role of glycosylation in driving resistance to HER2-targeted therapies. Aberrant glycosylation of proteins is a hallmark in cancer and has been linked to multiple processes such as invasion, angiogenesis and modulation of the immune response. The receptor HER2, the main driver of HER2+ cancers, is heavily glycosylated and is the target of current antibody-based treatments, including trastuzumab. In this scenario, this proposal aims to (1) identify glycosylation-related genes associated with incomplete pathological response to trastuzumab to (2) dissect their role on trastuzumab binding and (3) assess their impact in the response to trastuzumab mediated by immune cells. This research plan will be accomplished combining the analysis of clinical data from tumor biopsies, the use of trastuzumab-resistant tumor-derived breast cancer cell lines and, the implementation and imaging of 3D heterotypic cultures of cancer cell line-derived spheroids and immune cells. Thus, this proposal addresses a largely unexplored layer of complexity in cancer biology – the role of glycosylation in resistance to targeted therapies – and holds the potential to identify new markers of response to therapies and open the path to new therapeutic options for the improvement of current treatments.

Mots clés : breast cancer, her2, protein glycosylation, resistance, targeted therapy, 3d cancer spheroids, trastuzumab, biomarker, adcc

Participants :
- Erasmus MC (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175572.48 €
Projet EscaPI (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Resistance to anticancer drugs, which often develops from a heterogeneous pool of drug-tolerant cells known as minimal residual disease (MRD), is thought to mainly occur through acquisition of genetic alterations. Emerging evidence indicates that drug resistance may also be acquired in absence of a genetic cause. It remains unclear, however, whether genetic versus non-genetic mechanisms of resistance are selected in a stochastic manner, and what are the epigenomics mechanisms underlying the transition from drug-tolerance to resistance. This project aims at identifying the drug-tolerant subpopulation(s) that drive non-genetic resistance by performing lineage tracing and depletion experiments in pre-clinical models. Taking advantage of up-to-date technologies combining in vivo barcoding and single-cell multi-omics approaches, this project aims to provide a dynamic and integrated view of the evolution of epigenomic profiles -at single-cell resolution- before, during and after acquisition of drug resistance phenotypes in a in vivo clinically-relevant context. A third objective of this proposal is to search for predictive biomarkers of non-genetic resistance and to assess the percentage of melanoma patients that undergo non-genetic resistance through combination of multiplexed staining and targeted DNA sequencing. The success of this project is ensured by my personal background in epigenetics and related data computational analysis, the achievements of the JCM lab in melanoma epigenetic reprogramming and the close collaborations with experts in single-cell multi-omics fields. I anticipate that my involvement in this project will broaden my skills and knowledge and help me become a high-qualified European independent scientist.

Mots clés : non genetic mechanisms of resistance to cancer treatment, cancer, melanoma, single cell multi omics, epigenomics, enhancers, lineage tracing, barcoding, biomarkers

Participants :
- Vlaams Instituut voor Biotechnologie (Belgique) — Coordinator, beneficiary, Recherche, subvention : 178320.0 €
Projet MTUB-ANGIO (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Restoring normal vessel structure and function is now considered as a highly promising therapeutic opportunity for angiogenesis-related diseases, including cancer. Despite extensive use of microtubule targeting compounds in vascular-directed anticancer treatment, knowledge of the cellular mechanisms underlying microtubule regulation during angiogenesis is still elusive. By combining my previous experience in endothelial cell biology and the long term expertise of the host laboratory in microtubules dynamics as well as in high resolution imaging techniques, our project is aimed at studying microtubule dynamics and microtubule function in the precise context of sprouting angiogenesis. To achieve that goal, we propose to address the role of microtubule regulatory proteins using advanced high resolution live imaging of 3D culture of endothelial cells. We will identify endothelial specific MT regulators through expression, interaction and functional studies, assess their impact on microtubule dynamics during 3D tubulogenesis and validate their role both in the 3D morphogenesis model and in vivo, using zebrafish. This project is aimed at answering fundamental questions in the angiogenesis field as well as providing new opportunities for therapeutic strategies. At the same time, my experience in the laboratory of Dr Akhmanova will allow me to develop knowledge and skills in order to prepare me to reach a position of professional maturity.

Mots clés : developmental angiogenesis, microtubules, microtubule dynamics

Participants :
- Utrecht University (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 177598.8 €
Projet SmallDrugRheuma (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Rheumatoid Arthritis (RA) is an autoimmune chronic disease, characterized by inflammation in multiple joints, ultimately leading to joint deformity, pain and swelling. RA is one of the most frequent inflammatory arthropathies, with a prevalence of 0.3%-1%, striking during the most productive years of adulthood, and is a chronic disabling condition. No therapies exist to prevent RA, and a high percentage of patients do not respond to currently available therapies. Our research aims to integrate expertise on immunology and cutting-edge screening technologies to identify novel immunotherapeutics for RA based on immune modulation mechanisms. The project makes use of an extensive screening effort using a chemical library (60,000 compounds) containing repurposing drugs (drugs already approved for their use for the treatment of other diseases), targeted libraries and lead-like compounds. The aim of the project is to identify novel small molecules capable to modulate the immune response, counterbalancing the altered inflammatory environment that characterizes RA. Elucidation of the mechanism of action of the candidates (cell type, pathway and target) will take place through state-of-the art technologies such as chemoproteomics, RNASeq or CRISPR/Cas9. Ultimately, the most promising candidates will be tested ex vivo in cells from RA patients, providing a proof-of-concept of the therapeutic utility of the identified mechanism. The project is interdisciplinary and will make progress beyond the state of the art, as the identified immunotherapeutics could also be employed to treat other (auto)immune diseases, as well as being potentially translated to immunotherapy of cancer and cardiovascular diseases. The high-quality and originality of this proposal will open up the best career possibilities for the experienced researcher, and will be carried out under the umbrella of a public-private partnership with a pharmaceutical company, boosting European competitiveness.

Mots clés : pharmacology, rheumatoid arthritis, autoimmunity, dmards, chemical library, drug discovery, chemoproteomics, immunotherapy, high throughput screening

Participants :
- University of Santiago de Compostela (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 170121.6 €
Projet RHODOCAR (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

Rhodolith beds are one of the most extensive benthic ecosystems along the Atlantic coasts and key environments to continental shelf resilience. Besides providing substrate and habitat for numerous other algae and sessile invertebrates, their ability to calcify, their high abundance and biomass, makes rhodoliths major carbonate producers. Recent empirical estimations suggest that the carbonate marine deposits generated by these organisms represent a total potential carbon sink of 0.4 x 109 t C yr-1. Hence, giving the increasing role of marine ecosystems in the storage of blue carbon, rhodolith beds may represent a not yet considered significant carbon store. Regarding carbon sequestration, studies on rhodolith bed community metabolism are scarce and so far only available for two temperate beds that indicate that they can act both as CO2 source and organic carbon sink. As many marine ecosystems, rhodolith beds are currently under threat related to global climate change (GCC), with local impacts due to increasing coastal urbanization, potentially lowering even further their resilience. Thus, by using a physiological approach, this project will provide much needed information on the basic mechanistic understanding of rhodolith metabolism (photosynthesis, calcification), rhodolith responses to global and local stressors, and rhodolith bed community metabolism and carbon storage along a latitudinal gradient. Taken together, this information will allow assessing the importance of rhodolith beds as natural carbon sinks, thus, help ascertain whether these ecosystems meet the requirements to be integrated into climate mitigation policy, and will further allow quantifying the effects of GCC on their carbon sequestration and storage ability. In addition, it will help recognizing potential interactions between global and local stressors, hence, aid in the development of effective local conservation and management strategies.

Mots clés : carbon sequestration, calcareous algae, carbon storage, community metabolism, carbon flux, blue carbon

Participants :
- University of Algarve (Portugal) — Coordinator, beneficiary, Recherche, subvention : 147815.04 €
Projet RiboEscapers (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Ribosomes are RNA-protein complexes found in all living cells. Ribosome biogenesis is a complex, cellular process that is tightly coordinated with ribosomes demand to ensure optimal cellular adaptation, growth and proliferation. In eukaryotes, ribosomes are sequentially generated in key steps where the ribosomal RNA (rRNA) is folded, modified, processed, and assembled with ribosomal proteins (r-proteins) to form the two ribosomal subunits. Recently, the connection of defective ribosome biogenesis with human diseases has become clear. This is the case of the so-called ribosomopathies, human syndromes caused by mutations in genes encoding either r-proteins or ribosome biogenesis factors, which are known to increase the probabilities of cancer development. Considering the multi-steps pathway of ribosome biogenesis, the possibilities to introduce errors with possible harmful effects for cell viability are high. In this context, cells have developed multiple surveillance mechanisms to supervise the structural and functional integrity of the ribosome particle. When a preribosomal subunit suffers an assembly error, in most of the cases, the aberrant particle is retained in the nucleus. However, some aberrant pre-particles have been shown to escape the surveillance mechanisms and to be exported to the cytoplasm. This proposal, aims to explore the functional consequences of r-protein gene mutations, which generate defective ribosomal particles that are successfully exported to the cytoplasm (RiboEscapers) and actively participate in translation in yeast cell. For this purpose, the research action will combine traditional yeast tools together with state-of-the-art methodologies, such ribosome profiling to provide a detailed overview of the r-protein roles in ribosome biogenesis, as well as the consequences of specific defects in this process.

Mots clés : ribosome biogenesis, translation, quality control, saccharomyces cerevisiae, ribosomopathies

Participants :
- Universidad de Sevilla (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160932.48 €
Projet RoadNet_Andes (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

RoadNet_Andes research is interested in the palimpsestic character of road networks and their relation to the spatial structure and dynamics of territorial formations through time. Because of this palimpsestic character, the interpretation of road networks has always constituted a challenge for archaeological research interested in the long-term perspective of territorial formations, resilience and changes. Therefore, this research is aimed at developing an innovative geospatial approach for the chronological disentanglement of complex road networks. Using an Andean case study, the project will apply a multiscale analysis of an empirical archaeological record of great extent and integrity, in the framework of the macro-regional dynamics related to extended territorial formations between the Altiplano and the Pacific during the last millennium. This MSCA training through research, aimed at ER reintegration in Europe after an early academic career in Chile, will be realised at the Institute of heritage sciences (Incipit) of the Spanish National Research council (CSIC), with international partnerships. This structure will constitute an excellent research environment for both innovate GIS-based network analysis and digital landscape archaeology, as well as for the development of an anthropological critical perspective about the current politics of road networks heritagisation which constitutes a great societal challenge in a pluri-national frontier zone, like the study area of this project.


Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €