Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MIRDOT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

Mid-infrared (MIR) sensors are pivotal in enabling a broad range of applications, including environmental monitoring, medical imaging, safety, and food analysis. The current sensing technologies within this spectral range (λ= 3-30 μm) rely on high-cost and complex fabrications of epitaxially grown semiconductors. These sensors are not monolithic to silicon photonics and require cryogenic operating temperatures, limiting their adoption to the market. Alternatively, colloidal quantum dots (CQD) offer unique properties for sensing MIR light, including low-cost production, ease of processing, and silicon CMOS compatibility. The MIRDOT project will develop room-temperature (RT), cost-effective, and high-performance MIR sensors using CQD. So far, CQD technology has revolutionized the optoelectronics industry, particularly through the development of advanced sensors such as PbS CQD near-infrared (NIR) image sensors. These sensors leverage interband transitions in CQD, limiting their sensitivity to the NIR region. Intraband transitions in CQD, however, enable access to MIR region. Previously, doped PbS and HgTe CQDs have been investigated for MIR detection through intraband absorption. Nevertheless, these detectors exhibit extremely poor sensitivity at RT due to structural constraints and background noise in the MIR. In this project, I propose to effectively address these limitations by upconverting MIR radiation to NIR emission, enabling reliable detection with standard silicon detectors at RT. In this project, I will develop CQD-MIR sensors by coupling doped PbS(Se) CQD with extreme plasmonic nanocavities under optical pumping. To integrate these sensors with CMOS technology, I will design and fabricate electrically-driven sensors. Finally, as proof-of-concept phase, I aim to develop MIR imaging and gas sensors that operate at RT using these CQD-MIR sensors. The MIRDOT project will extend CQD technology into new spectral regions, greatly advancing future technologies.

Mots clés : plasmonic nanocavities, colloidal quantum dots, lead chalcogenide, doping, intraband absorption, infrared radiation, mid infrared, upconversion, photodetectors, cmos technology, silicon photonics

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet EnCHAANT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Chemical reactions, broadly speaking, can be mechanistically classified into two distinct types – those in which the electrons move singly and those in which they move in pairs, referred to as ‘radical reactions’ and ‘ionic reactions’ respectively. The remarkable volume of attention now being focused on radical reactions, due to the popularisation of photoredox catalysis, underscores a long-standing challenge within the field of radical chemistry – that of controlling enantioselectivity. This proposal will develop new catalysts that will perform a key mechanistic process in radical chemistry, hydrogen atom transfer, in an enantioselective manner. Specifically it will control asymmetry in the abstraction of hydrogen atoms. The proposal builds on very recent exciting results from the host group and will seek firstly to develop a process for catalytic deracemization and diols and amino alcohols, important chiral building blocks for synthetic chemistry and a range of applications. The second key goal will be to fundamentally modify the chiral scaffold used in the previous work, one that is based on the cinchona alkaloid natural products. Inspired by a recent paper showing DABCOnium salts to be more powerful hydrogen atom abstractors we will synthesise de novo DABCO analogues of the cinhona alkaloids using a route that has been developed, for other purposes, in the host group. The resulting catalysts should dramatically expand the scope of the process and have a large impact in the field of enantioselective radical chemistry. Finally, the combined insights from the main WPs will be used to enable late stage 'stereochemical editing' of complex pharmaceuticals, allowing one enantiomer to be converted to the other at will.

Mots clés : photoredox catalysis hydrogen atom transfer enantioselective catalysis oxidation radical chemistry

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet MARGICANTUS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Largely overlooked, if not entirely unknown, about a thousand musical marginalia lie in the empty spaces of Latin non-musical manuscripts of the early Middle Ages, where they are unlikely to come to the attention of music scholars. These marginalia, which I have for the first time systematically identified and newly described during my previous postdoctoral appointment, have the potential to bring us much closer to the composition, expansion and dissemination of new repertories and chants in the 9th and 10th centuries. Appearing in unpredictable places—empty flyleaves, blank spaces, lateral margins—in manuscripts of all sorts and written by individuals of all levels of competence, they provide invaluable and potentially transformative insight into the period before the well-known and calligraphic books of music of the late 10th and 11th centuries (i.e., larger notated antiphoners and graduals, and the newly-devised formats of tropers and sequentiaries).  From this body of a thousand marginalia, “MARGICANTUS: Tropes and Sequences in the Margins of non-Musical Carolingian Manuscripts, circa 800 – 1000” isolates a corpus of almost two hundred 9th- and 10th-century entries of tropes and sequences, two genres whose origin can be safely tied to the early 9th-century Carolingian world. These sketches, trials, and individual marginal items expand our understanding of plainchant chronology, repertory and transmission, tensions between local and imported styles of chant, the uses of musical notation, and the extent and urgency with which in Carolingian times newer music embellished older liturgical practices. Blending classic methods of musicology and philology with current computer-based analysis and data management, MARGICANTUS sheds new light on the history of tropes and sequences, and therefore of Carolingian music. By doing so, it recovers some of the earliest layers of Western musical creativity in their full complexity, beginning from the margins.

Mots clés : gregorian chant, medieval music, liturgy, marginalia, digital humanities

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet EXD-LnOLED (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

This research project, "EXD-LnOLED," aims to enhance the efficiency and functionality of lanthanide-based organic light-emitting diodes (Ln-OLEDs). OLEDs are efficient electroluminescent (EL) light sources for panel displays, light communication, and laser diode applications. To maximize efficiency, it is crucial to fully utilize excitons, which consist of 25% singlet and 75% triplet exciton states. Lanthanide complexes are ideal for OLEDs due to their unique optical properties, such as high photoluminescence quantum yield (PLQY), color tunability, and narrow linewidths. This triplet sensitization allows for potentially 100% utilization of exciton energy, leading to cost-effective EL devices. However, despite their high PLQY of around 80%, the external quantum efficiency (EQE) in operational OLEDs is limited to about 10%, restricting practical applications. The primary objective of this project is to develop in-situ/operando spectroscopic techniques to study exciton dynamics and energy transfer within operating Ln-OLEDs. By using advanced methods such as ultrafast transient absorption spectroscopy and time-resolved electroluminescence under in-situ/operando conditions, the research will uncover the mechanisms limiting current Ln-OLED efficiency. Additionally, the project will create innovative methods for detecting changes from electron injection, enhancing understanding of charge balance and dynamics in Ln-OLEDs. Ultimately, the project seeks to address efficiency challenges and achieve state-of-the-art Ln-OLEDs with the highest EQE. These insights will inform the design of high-efficiency devices, aiming for 100% exciton energy utilization, thus advancing energy-saving technologies and next-generation lighting solutions.

Mots clés : light emitting diodes, electroluminescence, trivalent lanthanide complex, energy transfer, photophysical properties

Participants :
- Université de Cambridge (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 276187.92 €
Projet FaecMet (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The analysis of human faecal metabolites can provide an insight into metabolic interactions between gut microbiota and the host organism; furthermore, it can be instrumental to not only treat, but also intercept or even prevent diseases. The present project proposes the development, validation and application of two complementary chromatographic platforms (GC/MS and LC-IM-QTOF-MS) in combination with solid phase microextraction (SPME) as a greener, high throughput sample preparation method for faecal metabolites study, more specifically, volatile organic compounds (VOCs) and bile acids (BAs). As a proof-of-concept, faeces from patients with anorexia nervosa (AN) will be analyzed and compared to that obtained from health individuals (controls) aiming to identify possible biomarkers and/or associations between metabolites. Furthermore, patients with AN display nutritional, metabolic, hypothalamic, and endocrine abnormalities, which can lead to them presenting modified microbiota. Interestingly, eventhough AN patients often avoid cholesterol-rich food, hypercholesterolemia is commonly diagnosed in AN patients. In this context, the current project also aims to investigate possible correlations between short chain fatty acids and bile acids levels, BMI, and blood lipidic profile (cholesterol) for patients with anorexia nervosa (AN) and healthy individuals (controls) individuals that could shed light into the gut health, development of hypercholesterolemia, and establish the microbiota role in the evolution of the disease. Moreover, this project aims to develop simple to execute, greener, automated sample preparation for faecal samples that could be easily implemented in clinical settings.

Mots clés : solid phase microextraction faeces metabolites biomarkers volatile organic compounds vocs short chain fatty acids bile acids sample treatment biocompatible anorexia microbiota

Participants :
- Centro de Estudios Universitarios (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 82656.48 €
Projet ADJUST (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

ADJUST investigaADJUST investigates the integration of Artificial Intelligence (AI) and Automated Decision-Making (ADM) in judicial systems, focusing on their impact on fair trials. There are almost 100 such systems in use in Europe alone, conducting tasks from menial transcriptions to complex matters such as suggesting relevant precedent or estimating the risk of recidivism. While AI promises to enhance the efficiency and coherence of adjudication, its use also raises concerns about bias, transparency, and the potential erosion of judicial discretion. Much existing research overlooks either the specific training and design of each system, or the role of court actors beyond judges, such as clerks and registrars, who interact directly with the systems and whose tasks are prone to automation. Overlooking these two dimensions risks oversimplifying the analysis of AI’s benefits and drawbacks. ADJUST fills this gap by pursuing three objectives: 1) Mapping existing ADM applied in courts, 2) Investigating why court actors do or do not trust and implement ADM, and 3) Understanding how ADM technology impacts the right to a fair trial.  The project employs an interdisciplinary approach, bridging human rights law and computer science. It does so by 1) mapping existing ADM applied in courts worldwide, and 2) conducting an in-depth comparative study of three legal systems: the European Court of Human Rights, and two Danish and two Italian courts. These case-studies are selected for their heterogeneity in legal systems and adjudicative procedure, use of precedent, and division of labour between court staff.  My publication record on AI, courts and judicial discretion, my current involvement in a technical Horizon project developing human right compliant AI, as well as the leading role of my supervisor and the iCourts Center at University of Copenhagen in empirical legal studies enable me to undertake this first systematic study on the impact of ADM on the right to a fair trial.

Mots clés : automatic decision making, court systems, adjudication, human rights, right to a fair trial, artificial intelligence, ai, comparative law, ecthr, european court of human rights, delayed justice

Participants :
- Université de Copenhague (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 263393.28 €
- Université de Messine (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Bocconi (Italie) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet Rabgres (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

The proposed project brings together Neha Nanda, a young researcher who finished her Ph.D this summer, and who already has a number of publications and pre-prints, and an experienced researcher, John Guaschi, who is full professor at Université de Caen Normandie. They propose to study certain ramifications of braid groups and related structures, namely the (virtual) twin groups, and the relations of these groups with (virtual) doodles that play the rôle of planar analogues of knots in R^3. The main aims of the project are: 1) understand better the (pure) twin groups by studying some of their invariants, such as their virtual cohomological dimension, and look for good presentations for them using Fadell-Neuwirth-like short exact sequences. 2) following the construction of surface braid groups from Artin braid groups, generalise the (pure) twin groups to surface (pure) twin groups, obtain presentations of these groups, and seek doodle-like structures to which they correspond. 3) construct new (virtual) doodle invariants, some being analogous to those known for knots and links, the aim being to classify (virtual) doodles. Being at the intersection of several domains, the general setting of the project is active and competitive. As well as being ambitious, the project is innovative, not just for the choice of problems to be studied, but also because its members have complementary interests and skills in algebra, low-dimensional topology, and combinatorial group theory. The project members will also be able to count on the expertise of other mathematicians in Caen working in related areas, as well as the dynamic network of the research group in Caen, including meetings organised by members of the GDR "Tresses", the regional ARTIQ project in collaboration with computer scientists in Rouen, and schools such as "Winterbraids".

Mots clés : braid groups twin groups doodles virtual knots and doodles surface braid groups knot and doodle invariants combinatorial group theory

Participants :
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Caen Normandie (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet FOCUS (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

Polarisation information is only accessible to a part of the animal kingdom. Available on land and underwater, it is used in a wide range of behaviours such as navigation, object recognition, foraging, or communication. Polarised information can derive either from the environment or from plant or animal reflective features and, in the latter case, it may be subject to selective pressure. However, the information conveyed by polarisation signals in any species is poorly understood. Among marine animals, cuttlefish are likely to possess the most acute resolution to discriminate angular differences in polarised light (e-vector). Not only do they excel at extracting polarised information but they also possess high-reflectance iridophores stripes on their arms that reflect polarised light. Yet, their functional significance remains uncertain, and the polarisation signals' neural processing is still unidentified. Furthermore, cuttlefish inhabit a wide range of ecological niches significantly varying in turbidity. While early exposure to turbidity affects individuals’ polarisation sensitivity, the role of turbidity in mature adult polarised communication and its impact are still unknown. Nonetheless, the consequences could be severe as turbid oceanic areas are currently expanding along with anthropogenic activity. To reveal the use of light that we cannot see this project will use cutting-edge technology and unfold along three axes. The first axis will use behavioural paradigms to investigate the use and the information content in cuttlefish polarisation reflective patterns. The second axis will evaluate the impact of visual sensory pollution on polarized communication by applying incremental turbidity to the cuttlefish environment. Finally, the third axis will build upon the latest advances in neurobiological technologies to explore the neural processing of polarisation signals.

Mots clés : turbidity, polarisation, communication, behavioural ecology, visual ecology, neural processing, cephalopods

Participants :
- Université de Caen Normandie (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 211754.88 €
Projet RECOVER-GEU (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

RECOVER-GEU presents an innovative gendered perspective on EU crisis politics and policies integrating theoretical and methodological approaches from political economy, EU, gender and policy analysis. The project aims to understand how the effectiveness of gender mainstreaming within the multilevel governance framework of the EU is moderated domestically by women’s representation. The project addresses whether women's substantive representation extends beyond parliamentary debates to (fiscal) policy outcomes in the case of the Covid-19 crisis and the National Recovery and Response Plans. RECOVER-GEU provides a timely gendered assessment of the ongoing flagship EU response to the pandemic and offers insights into the drivers of heterogeneous gender mainstreaming in the recovery, enriching the debate on the future of EU economic governance and gender equality policies. The project is methodologically innovative as it improves text-as-data approaches for classifying gender-sensitive policy-relevant content and extends civically engaged research methodologies to the multilevel, multilingual and cross-country context of EU politics and policies. The host institution and supervisor offer the fellow an ideal interdisciplinary and policy-oriented environment at the frontier of research on EU crisis responses and gender equality policies. The fellow will receive training in cutting-edge computational, qualitative and gendered policy methodologies. Additionally, she will gain unparalleled access to practitioners and an extensive network of partner institutions in all fieldwork cities and with renowned gender research centers. At the same time, EUI offers crucial research support and expertise in grant development and project management.

Mots clés : gender equality policies, gender mainstreaming, covid 19, recovery policies, rrf, ngeu, nrrps, eu economic governance, substantive representation

Participants :
- Institut universitaire européen de Florence (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 164950.08 €
Projet PerfusedKidneys (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Kidney transplantation is the gold-standard for end-stage kidney disease (ESKD) but there is a shortage of organs. To increase organ numbers, kidneys from deceased donors aged over 60 are now often used. These so-called “marginal” kidneys are susceptible to the ischemic tissue damage that occurs during transplantation, and tend not to function as well, nor last as long, as kidneys from younger donors. Cell therapies administered into the renal artery prior to transplantation have potential to repair marginal kidneys. Adipose derived regenerative cells (ADRCs) are an attractive cell therapy because they can be isolated from the perinephric fat surrounding the donor kidneys, and can improve kidney health in rodent models. However, difficulties in evaluating ADRCs in human donor kidneys is a barrier to clinical translation. We need to monitor the biodistribution of the cells within the kidneys to ensure they do not form emboli, as well as measure the therapeutic effects of the cells on kidney function and tissue health. Recent technological advances in machine perfusion and imaging makes it possible to overcome these barriers. With machine perfusion, kidneys can be perfused outside the body (ex vivo) prior to transplantation, allowing their function to be assessed. Furthermore, a highly sensitive novel imaging technique called “magnetic particle imaging” (MPI), will enable the biodistribution of labelled cells to be determined with great accuracy. In this project, I aim to address these questions using marginal human kidneys that are not deemed suitable for transplantation. The University of Liverpool is uniquely positioned to host my project, being the only centre in Europe with expertise in both ex vivo perfusion as well as having an MPI scanner. If successful, my project could expedite the clinical translation of ADRCs and improve the performance of marginal kidneys. This would improve the lives of ESKD patients by keeping them off dialysis for longer.

Mots clés : ex vivo kidney perfusion magnetic particle imaging stem cells

Participants :
- Haemair ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Liverpool (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €