Projet GLIORESOLVE (Horizon Europe, appel à projets 2021)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Isocitrate dehydrogenase wildtype (IDHwt) glioblastoma (GBM) is the most frequent, aggressive and lethal brain tumour. It has a universally fatal prognosis with 85% of patients dying within two years. Effective precision medicine therapies are thus urgently required. This can only be achieved by focused multi-sectoral collaborations in innovative research disciplines. Overall, GLIORESOLVE will exploit the intractability of GBM to address European applied biomedical research training needs and will train 10 innovative, entrepreneurial doctoral researchers (DRs). The research objectives of GLIORESOLVE are i) to extend immunotherapy options to IDHwt GBM patients and identify novel tumour microenvironment (TME) subtype-specific therapeutic targets, (ii) develop and optimise state of the art pre-clinical models that recapitulate GBM TME-subtypes and (iii) test novel rationally selected (available) drugs / drug combinations for precision treatment of IDHwt GBM based on TME subtype assignment. Cumulatively, the programme seeks to generate sufficient data to support a post-project Phase 2 clinical trial. The consortium brings together leading European academics, clinicians, private sector and not-for-profit partners, and incorporates disruptive research methods including multi-omics, ex-vivo ‘tumour-on-a-chip’ assay development, computational modelling and systems biology. Overall GLIORESOLVE provides a comprehensive translational research strategy that goes significantly beyond the current state-of-the-art in neuro-oncology, to establish a new TME-targeting precision medicine platform for this incurable disease. The GLIORESOLVE network addresses current needs in academia and the private sector to train doctoral researchers in an environment that spans multiple disciplines. Thus, GLIORESOLVE DRs will be able to navigate confidently between clinical, academic and private sector environments to progress applied research findings towards improved patient outcomes.

Mots clés : glioblastoma, preclinical models

Participants :
- Institut du cerveau (France) — Partner, beneficiary, Recherche, subvention : 282693.6 €
- GeneXplain (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 260539.2 €
- Royal College of Surgeons in Ireland (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 286488.0 €
- International brain tumour alliance (Royaume-Uni) — Partner, associated partner, Autres, subvention : 0.0 €
- Arjuna therapeutics s.l. (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Sorbonne Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Carthera (France) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- SB Science Management (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Luxembourg Institute of Health (Luxembourg) — Partner, beneficiary, Recherche, subvention : 262620.0 €
- KU Leuven (Belgique) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 262620.0 €
- Vlaams Instituut voor Biotechnologie (Belgique) — Partner, beneficiary, Recherche, subvention : 262620.0 €
- Université Johann Wolfgang Goethe de Francfort-sur-le-Main (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Érasme de Rotterdam (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 274370.4 €
- Miltenyi Biotec (Germany) (Allemagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Hôpital de l'Université d'Oslo (Norvège) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université du Luxembourg (Luxembourg) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Mass General Brigham (Etats-Unis) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Heidelberg (Allemagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 434232.0 €
- Laboratoire National de Santé (Luxembourg) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Mimetas (Netherlands) (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 274370.4 €