Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet DOC-Stim (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

Persons with a disorder of consciousness (DOC) have little or no ability to interact with people and devices. They are unable to control voluntary movement, and hence they cannot speak, blink, use devices for communication, or otherwise convey their needs and desires. Recent work from our group and others has shown that new methods and devices based on real-time EEG can help re-assess DOC patients’ cognitive functions and provide basic communication for them. Other work found that new tools to noninvasively monitor and stimulate brain activity could substantially improve recovery of persons with stroke or other disabilities. EEG data can detect each patient’s motor imagery and thereby influence multimodal feedback in real-time. This feedback may include VR avatars, functional electrical stimulation, and potentially even magnetic or electrical stimulation of motor areas of the cortex. This promising new research direction requires extensive collaboration across disciplines and sectors, and experienced researchers (ERs) with relevant experience. We will capitalize on our progress in both communicating with DOC patients and our new system for rehabilitation to get the project started quickly. The project will explore to create a new system that will be used to collect data with DOC patients. We will analyze the resulting data to develop new knowledge and contribute to improved tools that therapists and physicians can use. DOC-Stim includes extensive dissemination and communication activities to convey our project results to numerous audiences. The varied training activities will supplement the ER’s training-by-research to help prepare him for a high-impact career working across industrial, academic, and medical sectors. DOC-Stim will help position the ER for a leadership position in a rapidly growing new field while fostering technologies that could help restore movement for people who currently have little hope.


Participants :
- G.tec medical engineering spain sl (Espagne) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 160932.48 €
Projet PharmaCrystEng (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Pharmaceutical industries face continuous challenges in terms of process development for new drug substances and product. Considerable amount of time and resources, both human and material, are spent on the engineering research, including the process, scale-up and control development for the promising molecules synthesized often in micro-gram scale firstly. Crystallization is a particularly important in the pharmaceutical industry as it links the drug substance (active pharmaceutical ingredient) and drug product (e.g. tablets, injectables etc.) manufacturing. Good operation of crystallization is not only important to achieve the desired yield, but the purity, polymorphism, chirality and also the particle size and shape strongly impact the performance of the drug product, e.g. the bioavailability, dissolution rate and, not rarely, the toxicity. Crystallization processes are currently being designed in pure experimental fashion, relying on the pharmaceutical Quality by Design (QbD), which undoubtedly moved and moves the pharmaceutical industry forward, but it has tremendous experimental burden. The digital era paws the way for competitive and often complementary computer aided process design techniques. The goal of this project is the development of novel process systems engineering methods that are suitable for rapid and robust-optimal crystallization process design. For experimental and simulation demonstration, to keep the simplicity without loss of generality, a challenging but frequently occurring pharmaceutical crystallization process will be considered: the preferential crystallization of enantiomers. For rapid experimental design, process analytical technology based feedback and feedforward control techniques will be developed as a direct alternative for QbD strategies. Multi-population balance models will be developed and applied for optimizing digital design as well as for scale-up and potential batch-to-continuous process transition analyses.

Mots clés : population balance models, crystallization control, optimization, optimization driven experimental design

Participants :
- Budapest University of Technology and Economics (Hongrie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 151850.88 €
Projet Cleanup-MOFs (Horizon 2020, appel à projets 2015)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Pharmaceuticals and Personal Care Products as Pollutants (PPCPs) are regarded as an emerging class of contaminants and are often released directly into the environment after passing through wastewater treatment plants that are not equipped to remove them. Some PPCPs are easily broken drown and processed, but others are not easily degraded and processed, so they enter sewers. Although little is known about potential adverse effects on non-target species, these substances can be endocrine disruptors that mimic, enhance or inhibit the action of hormones. These compounds are a source of concern because they are widely used and then released in large quantities. On the other hand, the therapeutic misadventures, illicit drug ingestion or attempted suicide by using of harmful substances is a major worldwide public health problem that causes both a significant cost and severe heath problems, even death. Unfortunately, for the vast majority of these poisoning, there are no specific pharmacological antidotes and currently available detoxification methods are weak (<25% PPCPs adsorbed) and poorly prescribed. In this context, a new class of crystalline nanoporous materials known as Metal Organic Frameworks (MOFs) has attracted an increasing attention from academic and industrial domains. Compared to classical adsorbent materials, MOFs present several advantages: a versatile composition, which allows almost infinite combinations, a large structural variability, an important porosity with a large panel of pore sizes and shapes, ranging from the micro to the mesopore, and the easy modulation of their physicochemical properties by the simple functionalization of the organic linker, including different functional groups. Taking into account MOFs advantages, the objective of the present project is to develop MOFs specially tailored for the removal and degradation of very harmful pollutant from wastewater, as well as for human detoxification.

Mots clés : metal organic frameworks, toxin, adsorption, catalysis, bioapplications, wastewater

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 173076.0 €
Projet NERS (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Pharmaceuticals for cancer therapies and other diseases are very since the production of therapeutic molecules such as antibodies is costly and every production process needs to be developed individually. Especially purification processes, which make up to 80-90% of the whole production, need to be improved or new ideas need to be developed. Short peptide sequences, so called “tags”, can be used to create new purification strategies based on the biomolecule recognition of these sequences. Magnetic iron oxide nanoparticles are an interesting counterpart for peptide tags as their properties facilitate an easy handling and manipulation. The key to the design of high-affinity peptide tags lies in an in-depth understanding of surface-peptide recognition patterns. I developed such a magnetite-binding peptide tag which allows the purification of tagged model proteins from fermentation broths by changing the surrounding media. However, such pH and buffer switches might also alter the properties of pharmaceutically relevant proteins such as antibodies. The challenge of this project is to establish a novel elution process based on an electrical potential switch instead of a pH switch. The process contains the magnetic separation of proteins containing the peptide tags and the elution of proteins based on the change of tag-particle interactions with electric fields. The use of this system will help to understand the binding of proteins to iron oxide nanoparticles and the formation of an electrochemical double layer in external fields. The electrical double layer formation is not only interesting in biotechnological processes but for the understanding of electrochemical catalysis and energy storage. This idea might pave the way to completely new approaches in biomolecule recognition, protein detection and purification.

Mots clés : bio nanotechnology, magnetic nanoparticles, electrochemical double layer

Participants :
- Massachusetts Institute of Technology (Etats-Unis) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Technical University of Munich (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 176036.16 €
Projet PhiloMagic (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

PhiloMagic is an interdisciplinary project in philosophical aesthetics in the analytic tradition. It focuses primarily on the art of theatrical magic (think David Copperfield, not Harry Potter), which the American Society for Aesthetics recognizes as a “neglected art.” PhiloMagic builds on my prize-winning essay, “The Experience of Magic,” which is the first systematic philosophical treatment of theatrical magic in the analytic—or, to my knowledge, any—tradition. For my fellowship, I propose a 24-month stay at the Centre for Philosophical Psychology at the University of Antwerp under the supervision of Professor Bence Nanay. While in Antwerp, my main objectives are to complete a book manuscript (entitled *The Art of the Impossible*), write and submit for publication three accompanying scholarly articles, and organize a series of four study groups (each culminating in a public lecture) as well as an international workshop in the philosophy and psychology of magic.

Mots clés : aesthetics, philosophy of art, philosophy of magic, philosophy of mind, psychology of magic, history of magic, impossibility, wonder

Participants :
- University of Antwerp (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 172800.0 €
Projet NanoPhosTox (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Statut du projet : SIGNED

Phosphorus (P) is a key nutrient with crucial importance for agriculture and global food security. Phosphate rock is an intensively exploited finite resource, concentrated only in a few countries worldwide, leading to strong import dependency and insecurity for countries with resource deficits. Thus, in 2014 the EU Commission declared P rock as one of the 20 critical resources for the EU. Recently, significant efforts and priority funding were focused on developing materials and technologies for P recovery from secondary P rich sources, such as wastewater, following the EU Circular Economy paradigm. Engineered nanostructured materials, predominantly metal oxides/hydroxides, have been frequently reported as excellent sorbents for P in wastewater. However, the uncertainty regarding possible ecotoxicological hazards arising from the use of these custom materials has produced new research gaps. The main purpose of this Marie Curie action is to assess the environmental risk and potential toxicity of a novel, highly efficient nanostructured P sorbent material and optimize its structure to exclude any ecotoxicological risks from its application. Following the interdisciplinary approach bridging Nano-Toxicology, Materials Science and Environmental Engineering, “NanoPhosTox” will explore various test systems to evaluate the biological effects of the proposed material. Attention will be focused mostly on ecotoxicity tests based on OECD and ISO test protocols, such as Vibrio fischeri, Algae and Daphnia assays, which allow assessing toxicity effects of the material’s precursors, including nanoparticles. Thus, “NanoPhosTox” will build on the previous successful research which established the fundamentals of an innovative, robust and highly competitive technology for the simultaneous removal and recovery of P from wastewater. The ultimate goal of this action is to advance the further commercialization of the technology by verifying its environmentally friendly application.

Mots clés : phosphorus recovery, nutrients recycling, wastewater treatment, reversible sorption, nano structured sorbent materials, ecotoxicity, magnetic particles, nanoparticles, magnetic separation

Participants :
- National Institute of Chemical Physics and Biophysics (Estonie) — Coordinator, beneficiary, Recherche, subvention : 154193.28 €
Projet RECaPHOS (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Phosphorus (P) is an essential nutrient and major economic factor. The EU covers its demands by importing Phosphate rock listed as critical raw material due to its scarce resource. Sewage sludge from waste water treatment plants is a promising alternative source of P. RECaPhos focuses on development of a novel method for phosphorus recovery based on the thermo-chemical reaction of sewage sludge, in the presence of CaO in a fluidized-bed reactor, assuring in the same time the destroy of dangerous pathogens, antibiotics and contaminations. Goal is to develop, optimize, and evaluate the novel method and to provide rules and data for process up scaling purposes. This will be achieved by means of development of innovative models to investigate the thermodynamic and chemical process taking place. Experimental data from host institution facilities and data from literature will be used for models validation and optimization. The results will be used as a basis for the design of a demo plant as well as for the identification/evaluation of the process economics and commercialization potential. Two reference cases will be studied, one for a new plant and one for a retrofit of an existing fluidized bed combustion plant. Comparison with other competitive processes will be realized. RECaPHOS is original, highly innovative, and ambitious since the same cheap widely available, natural, non toxic, and environmental friendly Ca-based material is used for P adsorption and subsequent P recycling as it is directly used as feedstock for fertilizer production, closing a natural cycle. RECaPHOS is an excellent and unique opportunity for the researcher who is a mother of two daughters to restart her career after more than 4 years of career break prior to call deadline due to maternity and after resettling back to Europe/Germany after a 3 years continuous stay outside Europe in the last 5 years, in a highly innovative non-profit academic institution that supports women and work life balance.

Mots clés : sewage sludge, phosphorus recovery, fluidized bed technology, combustion, process design, technoeconomical assessment

Participants :
- Zentrum für Sonnenenergie- und Wasserstoff-Forschung Baden-Württemberg (Allemagne) — Partner, beneficiary, Recherche, subvention : 152788.08 €
- Karlsruhe Institute of Technology (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 109421.52 €
Projet PhotoCuRiOT (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

PhotoCuRiOT is envisaged and designed to develop novel synthetic tactics to biologically significant cyclic and acyclic nitrogenous organic compounds via visible light-mediated Cu(I)-based photoredox catalyst-assisted ring-opening transformation of small ring aza-heterocycles and aminocarbacycles. Considering the earth abundance and low cost, Cu(I)-based complexes, especially copper(I) phenanthroline derivatives, are recently being used as efficient photocatalysts and as low-cost alternative to the Ru or Ir-based complexes. A range of Cu(I)-complexes will be screened for optimizing the efficiency of the aforementioned ring-opening transformation processes. The most effective catalyst will oxidatively activate the substrates and the reactions will proceed through the generation of photoinduced reactive species (primarily amino radical cations) that can be productively harnessed for the synthesis of a range of high-value functional motifs after successive ring opening and annulation with suitably functionalized nucleophiles. PhotoCuRiOT will address the long-standing problem of finding an appropriate classical activation mode for different varieties of small ring aza-heterocycles (non-activated and activated) by offering a unique generic activation mode through the formation of amino radical cationic intermediates. PhotoCuRiOT also aims to bridge the gap between the fields of medicine and energy by enabling facile and highly selective synthesis of a wide array of high value heterocyclic moieties by utilizing copper complexes as environmentally benign photoredox catalysts and visible light as a sustainable source of energy. The successful photoactivation and subsequent ring-opening/expansion transformations of azacyclopropanes and azacyclobutanes would also allow late stage functionalizations of many drugs based on these heterocyclic skeletons such as ciprofloxacin which is a widely-prescribed cyclopropylamine-containing antibiotic.

Mots clés : photoredox catalysis, copper, ring opening, aziridines, azetidines, cyclopropane, cyclobutane

Participants :
- University of Regensburg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 159460.8 €
Projet SCHiMAT (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Photocatalysis is important for solving the worldwide energy shortage and environmental pollution issues. Recently, silicon materials are considered to be promising catalysts. In particular, size controlled Si clusters/nanoparticles/QDs show tunable emissions/absorption from near infrared to blue wavelength, making them promising candidates as photocatalysts. However, the research on the Si clusters based photocatalysts is still slow progress due to lacking of methods of fabrication of Si clusters with precision and in large quantities. In addition, unlike the widely studied Au and Ag nanostructures, which have distinct and well-defined SPR absorption peaks , small (<10nm) Si nanoparticles always exhibit low extinction from the ultraviolet to short wavelength of visible light, and thus result in lower photocatalytic efficiency. In SCHiMAT, the luminescent, photoelectric and photocatalytic properties of Si clusters with precisely controllable size and high production, which produced by “Matrix Assembly Cluster Source” (MACS), will be systemically studied. Based on that, this project will entail the design of a novel kind of hierarchical structure, which involves the choice of spherical semiconductor nanoparticles (SiO2, Al2O3, ZrO2, TiO2 CeO2 and ZnO NPs) and distribution modulation of the Si QDs on the semiconductor support, to largely enhance the photocatalytic efficiency of Si QDs, which is distinct from a conventional photocatalytic efficiency enhancement strategy aimed at exciting surface plasmon by means of incorporating metal nanostructures. This project would open a promising new route to using Si cluster/QDs as visible-light absorber for solar energy conversion. The project combines ER and host supervisor’s expertise in nanocluster, photonics, catalysis research, and will equip the ER to carry out cutting edge research in cluster-based nanomaterials and photocatalysis.

Mots clés : silicon cluster, photoluminescence, photocatalysis, hierarchical nanostructure, near field absorption

Participants :
- University of Birmingham (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 183454.8 €
Projet EDIFY (Horizon 2020, appel à projets 2018)
Action : Doctoral Networks - Industrial Doctorates
Panel : Information Science and Engineering
Statut du projet : CLOSED

Photonic integration (PI) is a new standard for providing cost effective and high-performance miniaturized optical systems for a wide range of applications. However, higher adoption of photonic IC-based products and services across a wide range of verticals still calls for several optimizations namely at the level of active material for the lasers, decrease of the overall waveguide loss and development of better predictive performance methodologies implemented in the Process Design Kits (PDK). EDIFY will overcome this challenges by providing cutting-edge training to young researchers on the emerging field of integrated photonics and its translation into circuit fabrication and commercialization. EDIFY will train three ESRs at two world-leading European academic institutions and four industrial companies, thus forming a strong interdisciplinary network between industry and technical sciences to overcome specific barriers of the integrated photonics sector. Skilled in a multidisciplinary background (i.e. photonics fundamentals, circuit design and dedicated software and nanofabrication modalities) EDIFY ESRs will jointly contribute for significant improvements in the performance, power consumption and predictive methodologies of current PICs technologies with direct impact in: data communications, fibre-tothe- home, fibre sensors, gas sensing, medical diagnostics, metrology and consumer photonics. The availability of professionals combining the EDIFY ESRs skills will directly fuel emerging PIC-based innovation and ensure its exploitation by the photonic industry. Importantly, with these emerging opportunities unique career opportunities will arise for the professionals involved in this technological step change in Photonic ICs segment.

Mots clés : photonic integration, photonic integrated circuits, generic photonic foundry concept, multi, project wafer, indium phosphide  inp, semiconductors, process design kits

Participants :
- Bright photonics bv (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Smart photonics bv (Pays-Bas) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €
- PhoeniX Software (Netherlands) (Pays-Bas) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Universidade de Vigo (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 1003619.52 €
- Eindhoven University of Technology (Pays-Bas) — Partner, organization partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Photon Design (United Kingdom) (Royaume-Uni) — Partner, organization partner, Organismes privés (hors enseignement), subvention : 0.0 €