Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet MIBWAM (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

“Marseille and the (Im-)Mobilities of Black Maritime Workers in the African Mediterranean” (MIBWAM) is an interdisciplinary and intersectoral project dedicated to illuminating Africa’s place in the global history of labour, port cities, colonialism and world oceans. The objective of the research, under the supervision of Prof Xavier Daumalin (AMU/TELLEMe), is to uncover the intersections of docks and decks in the life of African maritime workers within the French empire, which subverts common narratives of early globalization as an age of borderless circulation. The results will greatly impact the international debate on global social history. Furthermore, from the vantage point of the (im-)mobilities of Black maritime workers in Marseille, the project conceptualizes a modern history of the “African Mediterranean” as a way of obtaining a more integrated view of the Mediterranean world. This cutting-edge interdisciplinary endeavour can greatly advance the crucial transregional reconceptualization of areas studies. Finally, MIBWAM seeks to engage a wide range of publics in reflection on the entanglements of Africa and the Mediterranean, which will both influence non-academic audiences and diversify my skills. To achieve these objectives, MIBWAM adheres to a multi-methodological approach including archival research, and includes a research blog devoted to citizen science and involving a variety of participants. An additional non-academic placement at MuCEM, a museum devoted to the Euro-Mediterranean world, is intended to revisit its representation of Africa, enriching its collections and databases destined to inform exhibitions. MIBWAM will thus foreground the neglected topic of Africa’s relevance to the Mediterranean region in both the academic and museum sectors. In accordance with the Horizon strategy, MIBWAM is committed to breaking new ground in interdisciplinary research and to helping forge an inclusive and historically aware European society.

Mots clés : colonial africa, port cities, mediterranean, maritime labour, french imperialism

Participants :
- Musee des civilisations de l'europe et de la mediterranee (France) — Partner, associated partner, Organismes publics (hors enseignement & recherche), subvention : 0.0 €
- Aix-Marseille Université (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 264693.6 €
Projet SWIPT-PEMG (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The over 1 million individuals worldwide with significant functional impairment due to spinal cord injury, Amyotrophic lateral sclerosis (ALS), or Locked-in Syndrome face hardships in interacting with a world constructed for those with functioning musculature innervation. The higher the injury to the spine, via contusion or disease progress, the greater the disconnect from the normative way of operating in the world. Assistive devices that respond to the musculature innervated by the cranial, and more specifically the facial, nerves can ease the burden on these individuals by giving them an additional vector by which to affect the world around them.  The cranial nerves include those that humans do not commonly use to express on the modern world. These vestigial nerves provided function to ancestors, but now serve little purpose. One such vestigial musculature innervation are the periauricular muscles which oriented the ear in phylogenetically lower species. Even more significant though, functional innervation of these periauricular muscles remain even after the highest spinal cord injury.  By sensing the electromyography (EMG) signal resulting from these vestigial periauricular muscles and relaying that signal to an external controller via a wirelessly powered implanted EMG sensing and backscatter communication device, one can provide exactly this revolutionary additional control vector without sacrificing a single otherwise commonly accessible facial motor control unit. The proposed SWIPT-PEMG will be minimally invasive, of miniscule size, be battery free, can transmit at data rates up to 2Mbps, is extremely low cost, and is predicted to improve SNR by 25 to 40% over existing wearable systems, thus we will provide control without cumbersome electronics of EEG, without the invasive and perilous surgeries of ECOG, and without the massive power demands of both.

Mots clés : wireless, implantable, emg, backscatter, wpt, swipt, neuroengineering

Participants :
- University College Cork (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 268568.64 €
Projet EVOLVE (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Endometrial cancer (EC) is the most common gynaecological cancer, and has an estimated incidence rise of more than 50% worldwide by 2040, mainly associated with increasing obesity prevalence. In 2018 alone, there were approximately 380,000 new cases and close to 90,000 deaths attributed to EC worldwide. Thus, there is a growing need for the development of better platforms for inexpensive, early stage EC diagnosis and treatments. Immunotherapy has shown a sharp increase in survival rate in various cancers, but only in a small percentage of treated patients. The lack of reliable biomarkers for the selection of this sub-group of patients is a great hindrance to its broader application in the clinical setting. However, microsatellite instability (MSI) has been shown to be a good candidate for immunotherapy selection. MSI evaluation requires genetic material from tumors, which can be found in extracellular vesicles released by EC cells to the bloodstream. “Isolation and Analysis of Extracellular Vesicles using OptofLuidics for the eValuation of Microsatellite Instability in Endometrial Cancer (EVOLVE)” is thus a project focused on the development of an integrated solution for the enrichment and analysis of extracellular vesicles from body fluids of endometrial cancer patients to assess microsatellite instability using lab-on-chip, microfluidics methods in conjunction with DNA biomarkers and surface-enhanced Raman scattering technology.

Mots clés : microfluidics, raman spectroscopy, extracellular vesicles, endometrial cancer

Participants :
- Instituto de Investigación Sanitaria de Santiago (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- International Iberian Nanotechnology Laboratory (Portugal) — Coordinator, beneficiary, Recherche, subvention : 156778.56 €
Projet AVIGNONMUSIC (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

This interdisciplinary project will reveal how musical life in Renaissance Avignon (c.1500–1630) was directly interlinked with events happening on a broader religious, social and political level. Alongside being the first in-depth study of Avignon’s musical life during this period, it represents a significant and much-needed departure from the Parisian/royal court focus that has typified almost all previous scholarship on French Renaissance music. Two fundamental issues will provide the basis for this investigation: a) the question as to whether Avignon’s musical life can be said to reflect localised and/or nationalised trends; and b) the effect that Avignon’s unique status as a Papal enclave had on its institutions and musical practices (for example, in the presence of Italian personnel or musical developments). These broader issues will serve as a backdrop for exploring the full spectrum of musicians’ professional activities, as well as the various contexts within which they made the city resound – i.e. from its ecclesiastical establishments (such as Notre-Dame des Doms Cathedral and the Collégiale Saint-Agricol), to the instrumentalists attached to the city’s guilds, to the various civic spectacles within which musicians participated (like ceremonial entries). The results of this innovative survey will thus constitute a major contribution to the fields of early modern soundscapes and cultural studies; by extension, they will also shed new light on Avignon’s urban identity at this time, thereby leading to a better understanding of music making in France during the long sixteenth century.

Mots clés : music, festivals, civic communities, early modern soundscapes, religious practice, conflict, national identity

Participants :
- Université de Tours (France) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 195914.88 €
Projet MAGNOSTICS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Cancer is a leading cause of death and is a major impediment to increasing life expectancy around the globe. Amongst all breast cancers (BC), triple-negative breast cancers (TNBCs), are of much concern, as chemotherapy is the only option. However, it is associated with chemoresistance owing to drug efflux. Moreover, since TNBCs are negative for estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER 2), treatment strategies targeting these receptors do not work. Combined strategies for TNBCs have strong potential in treating TNBCs, as compared to singular approaches. Thus, MAGNOSTICS aims to develop biomimetic cancer cell membrane (CCM) coated magnetic nanoparticles for chemotherapy, gene targeting, and magnetic hyperthermia as a triple strategy for TNBC therapy. In addition, MAGNOSTICS proposes multimodal theranostics incorporating MRI enabled by MNPs. To promote cellular uptake and immune escape, MNPs will be loaded with CDDP and siRNA and camouflaged with CCM derived from TNBC cells. CCM coating will utilize the homotypic targeting strategy for self-recognition and uptake of NPs. Thus, the objectives are; i) to synthesize and characterize CCM coated MNPs conjugated with CDDP and siABCB1, ii) to study the biocompatibility/uptake and single therapeutic strategies as proof-of-concept in 2D cell cultures, iii) To develop 3D multicellular tumor spheroids and demonstrate the effectiveness of camouflaged NPs as combined theranostic platform; iv) to ensure further professional development of the ER through training, dissemination and public engagement. MAGNOSTICS thus aims to improve TNBC treatment and impact society with the right term and place.

Mots clés : triple negative breast cancer, drug delivery, gene silencing, hyperthermia, magnetic nanoparticles, theranostics, biomimetic nanoparticles, homotypic targeting, 3d spheroid culture, combined therapies

Participants :
- International Iberian Nanotechnology Laboratory (Portugal) — Coordinator, beneficiary, Recherche, subvention : 172618.56 €
Projet uQuantEV (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The μQuantEV project aims to revolutionize the landscape of colorectal cancer (CRC) diagnostics through the development of a groundbreaking Point-of-Care (PoC) platform. Leveraging the emerging potential of extracellular vesicles (EVs) as robust biomarkers for CRC, this interdisciplinary endeavor combines cutting-edge microfluidic technology with advanced analytical methods to enable the sensitive, rapid, and cost-effective detection of CRC-specific EVs. By designing, fabricating, and characterizing a microfluidic EV enrichment module, the project pioneers an innovative approach for the selective capture of CRC-associated EVs from patient-derived samples. Simultaneously, a state-of-the-art fluorescence-based EV detection and quantification module is developed to provide accurate and real-time analysis of the captured EVs. These two modules are seamlessly integrated to create a Lab-on-a-Chip diagnostic platform capable of detecting CRC at early stages with exceptional sensitivity and specificity. Furthermore, μQuantEV places a strong emphasis on translational research, collaborating closely with clinical partners to validate the platform's performance using patient samples. The project also incorporates extensive open science practices to foster collaboration, transparency, dissemination of research outcomes. Upon successful completion, the μQuantEV platform holds the potential to revolutionize CRC diagnostics, offering a cost-effective, non-invasive, and efficient alternative to current screening methods. Beyond CRC, the technology developed in this project can pave the way for the application of EV-based diagnostics in various other diseases, driving advancements in personalized medicine and improving healthcare outcomes.

Mots clés : extracellular vesicles, microfluidics, immunoassay, colorectal cancer, biomarkers, point of care, lab on a chip

Participants :
- Université d'Oviedo (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
- International Iberian Nanotechnology Laboratory (Portugal) — Partner, associated partner, Recherche, subvention : 0.0 €
Projet DITNO (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The “Data is the new oil – a political history of the European computing industry” project investigates the history of the European computing industry from the aftermath of the second world war until the present. The research will be based primarily on companies’ archives, State Archives, and the historical archives of the EU, and will place the evolution of the European computing industry in relation with the development of a European oil industry, the most successful example of developing a strong and globally competitive Europe-made industry against America’s first-comer advantage. By analysing the reasons of the failure to also establish strong European actors in the IT industry, the project will allow to better understand the reasons for the decline in European productivity, as well as what the role of the European Union (EU) can be in promoting the development of national or infra-national strong IT companies, able to compete with the current dominance of US companies alone. Furthermore, the project will consider the problem of the data economy in a historical perspective, analysing access to data as a commodity, in parallel to the problem of access to oil which dominated the geopolitical economy of the 20th century, testing the literature on the history of commodities on access to data. This will allow to cover a gap in the current literature on the history of the European computing industry, which focussed almost exclusively on hardware and software. It will also update the literature from international and media history with a reflection rooted in history on the role of data for current economic development.

Mots clés : it industry, european capitalism, european businesses, european economic integration, data, oil industry, development, technology

Participants :
- Université de Rome « La Sapienza » (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
- Sorbonne Université (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Aarhus (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet ReNVi (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

In order to sustain the global food-energy-population dynamic of the anthropocene, mankind is ever-increasingly converting unreactive dinitrogen (N2) to reactive N (Nr), which then results in a cascade of positive (food and energy for people) and negative (damage to people, climate, biodiversity, and environment) impacts as Nr is distributed throughout Earth systems. To protect Earth’s ecosystems and drinking water supply and to mitigate climate change the discharge of Nr to the environment must be reduced. Even though wastewater treatment helps to reduce the load of Nr released to the environment, the wastewater treatment industry is still one of the major Nr-polluting sectors. Viruses are an important, but poorly explored, component of this system, reaching 10–1000-fold higher concentrations than in other aquatic systems. We propose that viruses are significant yet poorly understood regulators of efficient removal of Nr in wastewater treatment systems. The proposed project will bridge gaps of knowledge about the importance of viruses for Nr conversion processes in wastewater by specifically focusing on the interplay between host selectivity, alteration of host metabolism and abundance, genetics, and ecology of viruses from wastewater treatment plants. Making use of culture-independent techniques such as DNA-and RNA-SIP-targeted metagenomics and metatranscriptomics, as well as culture-dependent methods including physiological assays of newly established viral cultures the proposed project will deliver knowledge to what extent viruses regulate the removal of Nr from wastewater via symbiotic or lytic interactions with nitrifiers and denitrifiers. The outcomes of the project will provide fundamental insights to viral ecology and inform efforts for more efficient and sustainable operation of wastewater treatment plants.

Mots clés : virus ecology and genomics in wastewater, nitrifiers, denitrifiers

Participants :
- Biology Centre (Rép. Tchèque) — Coordinator, beneficiary, Recherche, subvention : 191918.16 €
- Université d'Aarhus (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet PALOMA (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : SIGNED

The Amazon is one of the world’s most biodiverse ecosystems and our greatest carbon-sink, but human activity and climate change are posing severe threats to its existence. We are still a long way away from knowing how sensitive plants in the Amazon really are to variations in temperature and precipitation. One way we can understand this is by looking at fossil pollen accumulated over thousands of years, which can be used to reconstruct what the forests looked like over time and how they changed. In the context of Amazonia, so far there hasn’t been a way to connect changes in the pollen assemblages with climatic events because the forests in this region are diverse and many areas respond differently to environmental factors, and there is not enough data to allow comparisons between sites. To understand the sensitivity of Amazonia to climate change, we aim to use pollen-based modelling to reconstruct changes in temperature, precipitation and seasonality in the lowlands of Ecuador and Peru. This will be achieved by collecting modern pollen samples and gathering other existing datasets from collaborators, as well as modern climate data recovered from meteorological stations. We will use these datasets to calibrate key existing fossil pollen records from the region thereby enabling the reconstruction of palaeoclimatic parameters through the use of ‘transfer functions’. By improving our database of modern pollen for the lowlands of Amazonia and applying novel modelling techniques, we aim to provide new knowledge about ecological tipping points, plant responses to abrupt changes, effects on population abundance and structure and lags in response to climate. This project represents a key advancement not only to the field of tropical palaeoecology, shedding light on the response of vegetation dynamics to climate change for a region where this is still so mysterious, but it also represents a major contribution to the conservation of a globally important biome.

Mots clés : amazon, calibration, forest sensitivity, palynology, transfer functions, gams

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 165312.96 €
- Université d'Aarhus (Danemark) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
Projet FRESH (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Historical records indicate that the onset of severe anthropogenic impacts on rivers, such as pollution and biodiversity loss, in western Europe started during the medieval and postmedieval periods due to an increase in cities and industries. This has not been extensively confirmed on a wide scale by archaeological research. In order to provide necessary pre-modern baselines to support modern day conservation in one of Europe’s most extensive and dynamic habitat types, an in-depth bioarchaeological approach is needed. The aim of this interdisciplinary project, Flanders' Riverine Exploitation and ecoSystems throughout History (FRESH), is to determine how freshwater fish exploitation and ecosystem health changed during the medieval and postmedieval periods in relation to socio-economic and human-induced environmental changes in Flanders, an industry rich region at these times.  To obtain these insights, I will refine and apply palaeoproteomic, elemental (Hg and Pb) and isotope (C, N, S, O, and Sr) analyses of archaeological freshwater fish bones from various sites in Flanders to make species-specific interpretations on the geographical origin of the fish, their ecology, and pollution of their environments. The obtained pre-modern baselines of historical species diversity, habitat degradation and the long-term effects of pollution on river environments are used to evaluate and support modern-day conservation. My current knowledge of historical aquatic exploitation and skills in bioarchaeology make me ideally suited for this project. In order to successfully implement FRESH, I will conduct the interdisciplinary research and receive hands-on training in the relevant analysis techniques at the Vrije Universiteit Brussel and during the secondment at the University of York under the guidance of Prof. Christophe Snoeck and Dr. Jessica Hendy respectively, who are both experts and leaders in their field.

Mots clés : archaeology, zooarchaeology, palaeoproteomics, biogeochemistry, isotope analysis, conservation, freshwater, fish, biodiversity, pollution, history

Participants :
- Vrije Universiteit Brussel (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200400.0 €
- Université de York (Royaume-Uni) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €