Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet SPECIALS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Machine learning (ML) is an emerging tool to accelerate the materials discovery, a crucial part of the global competitiveness of Europe. Conventional materials discovery has been based on voyages of chemists and materials scientists in the materials space. They have navigated themselves according to their experience-based maps in their brains to find novel materials from innumerable candidate materials. Then, how can novice researchers navigate themselves? The project SPECIALS (materialS maP for microstructurEs of inorganiC materIALS) will provide a map by leveraging expertise of the host and the experienced researcher (ER): inorganic chemistry, physical chemistry, and computer science. The project approach is distinct from the conventional ML approaches: the ER will focus on microstructures of target materials, because functionalities of the inorganic materials are microstructure-dependent. The target materials are battery materials considering the experiences of the ER. The map will be developed by ML to describe their structural changes upon charge and discharge in continuous manners so that novice researchers can easily compare similarities/dissimilarities of various materials. Required datasets will be provided by the host utilizing existing simulation results and new simulation to cover even amorphous structures. Because the simulation of microstructures is computation intensive, multi-fidelity methods will be applied to leverage various types of simulations at varying computational cost and accuracies. The research outcome has potential to be grown up to scientific and societal impact on the European battery research community. The project also focuses on the two-way transfer of knowledge by transferring data science knowledge of the ER to the host, and simulation and soft skills of the host to the ER. This two-way transfer will enhance the employability of the ER and the value of the host.


Participants :
- Université d'Uppsala (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 236340.0 €
Projet MPA (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

Monetising performance culture in French North and West Africa (MPA) investigates how the implementation of authors’ rights systems affected the production of African performance culture in the period from 1850 to 1960. MPA bridges the field of French colonial history and intellectual property history by analysing the establishment of performing rights societiey offices in North and West Africa and the consequences that these had for local artists and creative production. The goal of the research is dual: first, I aim to develop a historical theory of the legal acknowledgement and monetisation of music, drama, and other performance practises in North and West Africa. Secondly, I aim to provide an account of historical alternatives to the organisation of creativity that did not fit into the rights-oriented performance culture that developed in Europe. MPA is a historical analysis of archival sources that will be collected and cross-referenced from a number of institutions in France, Senegal, and Benin. One major outcome will be an open digital map outlining when and where performance rights society offices opened and closed in the region between 1850 and 1960. This will be done in collaboration with supervisor and host, Ashleigh Harris, who is the PI for the African Literary Metadata (ALMEDA) project at Uppsala University. Other outcomes will be the publication of two peer-reviewed articles, one on local resistance to authors' rights systems, the other on IP-literacy among African artists. To be able to undertake the archival analysis and to expand the research into African cultural history, the outgoing phase will be carried out at the Université d’Abomey-Calavi in Benin where Didier Houénoudé will supervise and host me. In addition, I plan a three-month secondment at the Institute des mondes africains (IMAF) in Paris, under the supervision of Mbodj-Pouye Aïssatou. Here, I will collect archival material and participate on IMAF seminars.

Mots clés : cultural history of law, french colonial post colonial history, intellectual property, collective management, performance, north and west africa, music and theatre

Participants :
- Centre national de la recherche scientifique (France) — Partner, associated partner, Recherche, subvention : 0.0 €
- Fondation de l’Université d’Abomey-Calavi : Incubateur Start Up Valley (Bénin) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université d'Uppsala (Suède) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 238478.25 €
Projet MAGICAT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

Magnetic nanoparticles show promising perspectives for an increasing number of biomedical applications, in particular magnetic hyperthermia, which is proposed as a non-invasive method for cancer therapy. The advances are limited by the complex behaviour of nanoparticles inside biological environments and the lack of sophisticated theoretical tools to tackle the problem. The project goal is to develop an advanced theoretical and computational model to investigate the basis of magnetic hyperthermia and provide tools for personalised therapy optimisation. The model will use state of the art techniques in theoretical magnetism and thermodynamics to describe, in a self-consistent way, the heat generation and transport inside and around the tumour. The new theoretical framework will allow quantifying the heat generated by each individual particle at nanosecond resolution. This will include the case of large particle assembles, where inter-particle interaction play a crucial role. The short time scale (nanoseconds) required by the fundamental aspect of the problem will be coupled with the large time scale (minutes/hours) required for the treatments by using a multiscale approach. To mimic the physical conditions of magnetic nanopaticles inside real tumour tissues, particles/tumour spatial configuration and properties will be based on experimental data. The model will be validated through an extensive collaboration with leading experimental groups. The final goal is to develop a publicly available documented software which can be used by the research community for basic theoretical studies, understanding of experiments, and as a tool for hyperthermia optimisation.

Mots clés : magnetic modelling, magnetisation dynamics, magnetic hyperthermia

Participants :
- Italian Institute of Technology (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet CARABELA-NF1 (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

HR+/HER2- breast cancer (BC) patients often show limited response to current neoadjuvant chemotherapy, highlighting the critical need for alternative therapeutics strategies. The combination of CDK4/6 inhibitors (CDK4/6i) with endocrine therapy (ET) is the standard of care in adjuvant treatment for HR+/HER2- BC, with the potential for significantly improved outcomes in the neoadjuvant setting. However, drug resistance remains a significant challenge, with a critical need for early-stage biomarkers to predict resistance. The CARABELA phase 2 clinical trial, led by Dr. Emilio Alba (the supervisor of this proposal), provides valuable data on the efficacy and resistance patterns of prolonged CDK4/6i plus ET in neoadjuvant settings. Previous research by Dr. Chica-Parrado (the candidate) identified NF1 loss-of-function (LOF) mutations as key drivers of resistance to both ET and CDK4/6i. The CARABELA-NF1 study aims to leverage this expertise to integrate preclinical data with clinical insights from the CARABELA trial. The objectives of CARABELA-NF1 project are: (1) To perform targeted sequencing of circulating tumor DNA (ctDNA) to identify genomic alterations associated with resistance to CDK4/6i or ET and correlate these with clinical responses. (2) To develop an NF1-loss signature (NF1sig) from cell line data and validate this predictive signature using RNA from pre-treatment samples in the CARABELA trial. (3) To conduct drug screening in HR+/HER2- BC organoids derived from patients resistant to ET and CDK4/6i with NF1 mutations, focusing on the activation of pathways induced by the treatment.  This project combines advanced genomic profiling with clinical trial data and drug screening to address the pressing need for effective biomarkers and novel therapeutic strategies in the neoadjuvant setting for HR+/HER2- BC.

Mots clés : hr breast cancer, neoadjuvant therapy, cdk4 6 inhibitors, predictive panels, resistance mechanisms, circulating tumor dna ctdna

Participants :
- Andalusian Public Foundation for Health Research in Biomedicine and Malaga (Espagne) — Coordinator, beneficiary, Recherche, subvention : 194074.56 €
Projet PyroVector (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

DPP9 (dipeptidyl peptidase 9) is a cytosolic serine protease. It recognizes and cleaves N-terminal dipeptides containing proline at the penultimate position. The enzyme is currently receiving strong international attention after it was reported that DPP9 inhibition induces inflammatory cell death (pyroptosis) in Acute Myeloid Leukemia (AML) cells. Pyroptosis is a lytic form of cell death that also causes a pronounced, local upregulation of the innate immune system. This is of particular interest to leukemia treatment because the immune response to leukemic cells is strongly suppressed. Very recently, however, reports have been published that identify other, non-cancerous cell types that also undergo pyroptosis upon DPP9 inhibition. This raises questions on how selective and safe DPP9 inhibition can be as a therapeutic strategy in AML. The host reported the first selective, nanomolar DPP9 inhibitors in 2023 and also discovered the first DPP9-degrading PROTACs (unpublished data). PyroVector’s mission is to selectively unleash these molecules’ pyroptosis induction potential against AML cells, by delivering them towards these cells with vector approaches. Given the general lack of knowledge on how to optimally target small molecules to AML cells, three molecules that recognize AML cells will be compared as vectors for DPP9 inhibitors: a monoclonal antibody, an AML cell-penetrating peptide, and a sialic acid analog. DPP9 inhibitors that are covalently linked to these 3 ligands, will be investigated in terms of internalization and pyroptosis induction in cells. Furthermore, AML selectivity and therapeutic potential in vivo will be characterized with the ultimate aim of validating the approach as a safe and effective therapeutic strategy for AML. Overall we are strongly convinced that this project can be an essential step toward a patient-friendly application of DPP9 inhibition or degradation in AML.

Mots clés : dpp9, serine proteases, pyroptosis, adcs, drug delivery

Participants :
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 191760.0 €
Projet REINFORCE (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The progression of cancer is closely associated with alterations in the mechano-cellular phenotype and in the structure and mechanical properties of the tumor microenvironment (TME) in a complex and not well-understood manner. Desmoplasia, a tumour-associated fibrotic reaction, is responsible for tumor stiffening, poses a major barrier to effective drug delivery. Although novel therapeutic strategies that target cancer cells are emerging, their efficacy varies due to intra- and inter-patient variability as well as tumor heterogeneity. Notably, photodynamic therapy (PDT) is gaining prominence as a compelling alternative. This two-stage treatment harnesses both light energy and a specialized drug (photosensitizer, PS) to target cancer cells upon activation by a specific wavelength of light. However, the effectiveness of PDT is greatly compromised by various resistance factors originating from the complex TME. These factors can present several biological barriers, including desmoplasia. In this project, we propose the use of TME normalization treatment with approved anti-fibrotic drugs in combination with PDT. We aim to test the hypothesis that the combination of anti-fibrotic drugs that remodel and normalize the TME with PDT can increase the PDT efficiency. The specific research objectives are focused on breast cancer (BC) and includes in vitro study of the effect of different components of PDT treatment on BC cells, in vivo study of the effectiveness of the combination of PDT with anti-fibrotic treatment in murine BC models and mathematic modelling to optimize the combination therapies. In the proposed project, the fellow will acquire scientific and complementary skills according to his personalized career development plan and through advanced training, international and inter-sectoral mobility will reach a position of professional maturity in research.

Mots clés : atomic force microscopy afm , anti fibrotic treament, photodynamic therapy pdt , mechanical properties, cancer

Participants :
- Lumoscribe ltd (Chypre) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Vet ex machina limited (Chypre) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université européenne de Chypre (Chypre) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 164328.0 €
Projet MiTAI (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Glioblastoma is a highly aggressive type of brain cancer that kills around 15,000 people per year in Europe alone. It also has a devastating effect on patients' quality of life. Therefore, the clinical need in glioblastoma management is one of the highest in oncology: effective treatments are dearly needed. Over the past decade, the brain tissue surrounding glioblastoma tumors has been intensively studied. In this so-called 'tumor microenvironment' (TME), microglial cells make up the bulk cell type. Although immune cells by nature, TME microglial cells are reprogrammed to take on a tumor-supporting role: they become immunosuppressive and start secreting growth factors and nutrients that fuel tumor proliferation. Autophagy, best known as a cellular recycling pathway, is a masterswitch that determines the immune status in microglial and other immune cells. It also supports the process of nutrient secretion in TME microglia. Therefore, inhibition of microglial autophagy can be a viable strategy to restore the immune response against glioblastoma tumors. Strong preclinical evidence in favor of this approach is available. However, translation into a new glioblastoma therapy is difficult, because the presence of autophagy inhibitors in the brain could also be dangerous to neurons. In response, this proposal wants to deliver and investigate autophagy inhibitors that selectively target brain microglial cells. A vectorizing approach is proposed for ULK1/2 inhibitors and PROTACS, which are very potent autophagy inhibitors. The proposal will thorougly investigate the compounds in vitro and in cellulo. For selected, highly promising molecules, in vivo proof of concept will be sought in a murine, orthotopic glioblastoma model. Next to obtaining selective and effective microglial autophagy inhibitors, the design of metabolically stable compounds with sufficient bioavailability in brain can be expected to be additional, prime challenges of the project.

Mots clés : glioblastoma, autophagy, ulk1 2, microglial targeting

Participants :
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 200400.0 €
Projet SPADArt (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The SPADArt project addresses a significant gap in our understanding of early modern European art by reconstructing the private domestic settings in which artworks were originally displayed and enjoyed. Despite the prominence of these artworks in museums today, little is known about their original spatial and material contexts such as the interiors and objects that surrounded them. This gap in our knowledge makes it impossible to fully understand the cultural and social implications of art display in historical daily lives and it hinders effective communication of these insights to the public in museums.  To bridge this gap, SPADArt develops a holistic spatial methodology that adds a critical spatial dimension to study artworks within their original contexts at home. Focusing on early modern Antwerp, the project leverages underexplored sources from the host institute, including extensive databases of probate inventories and digital historical maps, in combination with the researcher’s expertise in art history and digital methods. Drawing on these areas of expertise, SPADArt will mine large inventory databases and collect architectural evidence to develop typologies of premodern Antwerp houses in schematic 3D models and identify object ensembles around artworks and their spatial positions in houses across social strata. These outcomes will be integrated into a novel spatial methodology, which will be applied across case studies analyzing class-based and gender-specific art display as well as the role of art in religious practices at home.  SPADArt will add the critical yet missing expertise in material culture to the researcher’s skillset, providing a crucial foundation for future research and an independent research career. SPADArt's spatial methodology will offer new perspectives for historical research in social history, gender and religious studies while assisting museums worldwide in better contextualizing their collections, thereby enhancing public engagement.

Mots clés : early modern material culture, early modern netherlandish art, digital humanities and spatial turn

Participants :
- Université d'Anvers (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 216240.0 €
Projet EQUATOR (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Modern power systems have been increasingly penetrated with power electronic converters. This can be explained with the massive integration of renewable energy generation, energy storage utilities, transport electrification, industrial electric drives as well as the wide application of high voltage direct current (HVDC) and flexible alternate current transmission systems (FACTS). Power electronic converters have totally different characteristics compared to conventional synchronous generators as they are fully controllable devices with low inertial and very limited overload capability. These characteristics also increase the complexity to stability analysis of power systems dominated by converters. An accurate grid equivalent representation stands for a powerful tool to improve the efficiency for stability analysis of such system. In such context, the EQUATOR project aims to develop an effective grid equivalent representation for stability analysis of power systems dominated by power electronics under both small-signal and large-signal disturbances. The obtained equivalent representations will provide powerful tools for TSOs, OEMs and research institutes involved in the planning, design, operation and analysis of modern power systems. Furthermore, the project results will favour the evolution towards the future European Super Grid which involves a high penetration ratio of renewable energy generation and covers a large geographical span. The researcher’s previous work focused on computational analysis and steady-state grid equivalent representation for power-electronics-dominated systems, which demonstrates his appropriate profile to successfully implement the presented project under the guidance of the supervisor, who is an expert in stability analysis of power electronics systems.

Mots clés : grid equivalent, voltage source converter, small signal stability analysis, dynamic transient analysis, hvdc

Participants :
- KU Leuven (Belgique) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 175920.0 €
Projet G-TScon2D (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

G-TScon2D delves into the exciting realm of superconducting (SC) twistronics, where the manipulation of the twist angle between the layers has opened up new avenues for investigating unconventional superconductivity, quantum transport, and emergent phenomena. A significant research gap exists in understanding and harnessing the unique properties of twisted 2D SC materials. G-TScon2D will bridge the scientific gap through a correlated experimental and simulation approach. Its technological advantage lies behind the inherent SC nature of the planned materials, which is expected to lead to higher operating temperature, a critical condition in quantum computing application. The primary objectives of G-TScon2D are to unravel the quantum phenomena and electronic states that arise from stacking and twisting SC layers at precise angles and to explore the SC-to-insulating switching properties by applying vertical gate field. G-TScon2D is a multidisciplinary project in nature and includes the development of 2D SC twisted device fabrication and carrier transport characterisation. G-TScon2D will benefit from close collaboration with a simulation team in the host, which will provide insight into the properties of twisted SC structures and the impact of gate field on those properties. Discoveries in 2D SC materials will accelerate the development of quantum technologies within the EU Quantum and Graphene flagships goal: “Turn Wonder into Action”. G-TScon2D contributes to expanding Europe’s leadership and excellence in this research area, to starting a competitive European industry in Quantum Technologies, and to making Europe a dynamic and attractive region for innovative research, business and investments in this field. This Fellowship will help me to improve my scientific, transferable, and leadership skills. Such skills will assist me in achieving my primary goal of becoming an independent research leader, and improving my employability in academia.

Mots clés : van der waals heterostructures, twistronics, superconductivity, quantum technology, moir patterns

Participants :
- University College Cork (Irlande) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 215534.4 €
- Institut Paul Scherrer (Suisse) — Partner, associated partner, Recherche, subvention : 0.0 €