Projet QuanTII (Horizon 2020, appel à projets 2017)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

Health and disease are regulated, to a large extent, by our immune system. The immune system not only protects the body from infectious disease, but is involved in a number of conditions of increasing incidence and morbidity, such as diabetes, rheumatoid arthritis, inflammatory bowel disease and allergies. In cancer, the immune system can be both cause and cure; it contributes to chronic inflammation that promotes tumour development, but it can also provide the ultimate weapon against metastatic disease. Thus, the development of ways to harness, direct or restrain immune responses has great potential for enhancing human health. Understanding the mechanisms that control the abundance of different lymphocyte (a type of white blood cell) subsets is key to therapeutically targeting immune responses. Ultimately, this understanding must be sought in quantitative terms, explaining how the rates of cell proliferation, differentiation, survival and death are determined by molecular mechanisms and cellular interactions. Current immunological research is beginning to combine experimental approaches with mathematical analysis to quantitate immune dynamics. A severe obstacle to more rapid progress in this area is the lack of appropriately trained scientists. In this ETN, European scientists, with a rich track record in collaborative research and training, have come together to deliver a highly collaborative, multidisciplinary and intersectoral research training programme for 15 early stage researchers (ESRs) in Quantitative T cell Immunology and Immunotherapy (QuanTII).

Mots clés : adaptive immunity, application of mathematics in sciences, biological system analysis  modelling and simulation, computational biology, biostatistics

Participants :
- National University of Ireland (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 265674.6 €
- National University of Ireland (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 265674.6 €
- Bayer (Germany) (Allemagne) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 498432.96 €
- University of Leeds (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 819863.64 €
- AstraZeneca (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 273287.88 €
- German Cancer Research Center (Allemagne) — Partner, beneficiary, Recherche, subvention : 498432.96 €
- University Medical Center Utrecht (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 510748.56 €
- Utrecht University (Pays-Bas) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 255374.28 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 262875.6 €
- Imperial College London (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 273287.88 €
- AstraZeneca (United Kingdom) (Royaume-Uni) — Partner, beneficiary, Organismes privés (hors enseignement), subvention : 0.0 €