Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet EIGER (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The proposed interdisciplinary project,‘Embodied Institutionalism: A New Model for Gender Equity Reform’ (EIGER), will investigate how the value and limitations of emerging and existing reforms in higher education settings can be linked in part to their ability to constructively engage the embodied and affective capacities of institutional actors. EIGER examines how the embodiment (e.g., gender, ethnicity, race, nationality) of institutional actors, and the lived experience of these actors in tertiary settings, significantly bears on the success of any given institutional intervention to advance gender equity goals. This integrated focus on affect, embodiment, and institutions represents an innovative theoretical approach, which I call embodied institutionalism (EI). My embodied institutionalist (EI) framework recognizes the importance of attending to localized ecologies of affect that influence gender-based outcomes. Higher education contexts in Australia and in Europe exhibit marked differences. Engaging in a comparative analysis of how the affective and embodied norms particular to these contexts affect the success of institutional reforms and assist to sustain gendered inequalities promises to illuminate creative, local solutions to issues of gender inequity, and to have significant value for theorists and practitioners working in the non-academic as well as academic sector.

Mots clés : affect, emotion, embodiment, social imaginaries, gender inequity, institutions

Participants :
- Freie Universität Berlin (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 162806.4 €
Projet GeMeTIC (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The proposed project 'Gestural Meanings: Typology and Interface Constraints' (GeMeTIC) will investigate how gestures, i.e., hand/body movements and facial expressions, contribute to the meaning of spoken utterances. This question has recently gained substantial traction in formal semantics and pragmatics, but to fully address it, however, one needs to understand how the general potential of gestures to encode meaning is further constrained at various levels of linguistic representation (pragmatics, compositional semantics, syntax, linearization, prosody, articulation) and interfaces between those levels---an issue that still lacks a comprehensive investigation. GeMeTIC will address this gap by comparing the behavior of gestures that contribute "not-at-issue" content, i.e., secondary content added on top of the main message of the utterance, to spoken expressions with similar semantics along a range of dimensions: (i) behavior of not-at-issue gestures and spoken expressions under ellipsis and in attitude reports; (ii) behavior of indexicals (i.e., context-sensitive expressions such as 'I', 'here', and 'now') in the scope of quotative gestures and spoken expressions; (iii) non-compositional interpretations (i.e., interpretations that don't match the syntactic structure of the utterance) of expressive gestures and spoken expressions. The ultimate goal of GeMeTIC will be to build a cross-modal typology of not-at-issue meanings that specifies interface constraints on how different meaning types can be encoded in speech and gesture. To accomplish its empirical goals, GeMeTIC will rely on introspective judgements from individual speakers, corpus data, and quantitative data from experiments conducted online. The theoretical component of the project will bring together two major lines of research in formal linguistics: semantics of gestures and semantics of not-at-issue expressions.

Mots clés : formal semantics, gesture

Participants :
- University of Oslo (Norvège) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 202158.72 €
Projet SHoW (Horizon 2020, appel à projets 2017)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The proposed project (SHoW) investigates the roles that landscapes, skylines and astronomy played in past peoples' lives in order to determine the cultural relatedness between people along Europe´s Atlantic Façade. Specifically, it investigates the types of visual-scapes people chose for the erection of their megalithic monuments within and across regions, that clearly seem to have some kind of related megalithic tradition, but which is not yet understood. Focusing on the periods of intensive monument building in prehistoric Iberia (c. 4500-2500 B.C.) and Britain (3100-900 B.C.), innovative 3D technology, along with interdisciplinary approaches already brought to bear on past projects by the candidate, will assist in the reconstruction of past visual worlds of the megalith builders of western Galicia and Scotland. These, plus the development and use of new approaches in geospatial techniques, 3D technology, statistical approaches and database management are key for the determination of the roles that landscapes, skylines and astronomy played in past peoples' lives. By investigating the role of the natural world, this project upholds and extends UNESCO’s Astronomy and World Heritage Thematic Initiative, for the project recognises that the way people observed the land and the sky in the past is a repository for people’s perception of their world. Understanding these things opens the way for a new consideration of shared tangible and intangible values in the past. In this way, this MSCA candidate will produce insights into some of the most iconic representations of cultural remembrance in Europe, revealing whether the reasons behind erecting megaliths were the same for people in different regions of Europe´s Atlantic Façade, and if not, what the differences might have been, and why. Ultimately, SHoW will reveal the degree to which the people in these regions possessed shared worlds.

Mots clés : landscape archaeology, cultural astronomy, megaliths, gis  geographical information systems, iberia, scotland

Participants :
- Spanish National Research Council (Espagne) — Coordinator, beneficiary, Recherche, subvention : 158121.6 €
Projet MisterCHROM (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The proposed project aims at modeling the structure and mechanisms of sister chromatids cohesion, and how it coordinates with intra-chromatid organization to shape replicated human chromosomes and support fundamental biological mechanisms. Indeed, sister chromatids organisation and its contribution to cellular functions remained elusive due to the lack of appropriate techniques able to distinguish the identical sequences of sister chromatids. The recent development of sister-chromatid-sensitive Hi-C (scsHi-C) technique by Gerlich's group at the host institution enables, for the first time, genome-wide analysis of sister chromatids interactions. These data now require theoretical models based on general physical principles to understand the complex scsHi-C contact patterns and the mechanisms underlying the formation and maintenance of sister chromatids cohesion. I will use coarse-grained polymer simulations and analytical calculations to: (i) unravel the structural and statistical features of sister chromatids organisation, e.g. how cohesive linkages distribute on the genome and the relative impact on sister chromatids conformation and alignment; (ii) understand the interplay of cohesion with dynamic intra-chromatid loops and TADs formation; (iii) predict outcomes of system perturbations on chromosome conformations and functional implications in processes such as gene expression, mitotic chromosome organisation, and DNA repair. Because the topology of sister chromatids is uncharted territory, whatever new knowledge is gained by the modeling approach proposed in this highly innovative study will constitute important contributions to long-standing open questions in the field, and will outline pathways towards new directions to pursue in future research. Given the relevance for various physiological processes, the outcomes of this project will be highly relevant for biologists from various fields, as well as biophysicist. The opportunity and the timing are thus unique.

Mots clés : sister chromatids, cohesion, cohesin, polymer simulations, biophysical modelling, biophysics

Participants :
- Austrian Academy of Sciences (Autriche) — Coordinator, beneficiary, Organismes privés (hors enseignement), subvention : 174167.04 €
Projet CarboPorph (Horizon 2020, appel à projets 2018)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

The proposed project combines recent advancements in supramolecular porphyrin systems and polyyne chemistry to create and study novel hybrid compounds: carbo-porphyrin nanorings. This will include extensive synthetic work to find the most efficient working schemes for macrocyclic compounds with varying sizes and different peripheral substituents, while minimizing linear polymerization. Specific choice of the building blocks will be guided by computer-aided design to ensure appropriate connectivity and steric demands for subsequent cyclooligomerizations. The size selectivity will be further refined by using template-assisted covalent self-assembly utilizing differently coordinating templates. The electronic and magnetic nature of the target compounds will be studied in solution using a range of techniques, including Nuclear Magnetic Resonance spectroscopy, UV-vis-NIR absorption and fluorescence spectroscopy and electrochemical methods, additionally characterized with X-ray crystallography in the solid state. These efforts will be focused on exploring global aromatic and antiaromatic currents in the neutral and oxidized forms of the macrocycles, gaining insight into the nature of aromaticity in nanometer-size pi-conjugated systems and contributing to the design of future functional materials.

Mots clés : aromatic porphyrin nanorings, carbo compounds, carbo mers, template directed cyclooligomerization

Participants :
- University of Oxford (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212933.76 €
Projet SPEAKER DICE (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : CLOSED

The proposed project deals with Speaker Diarization (SD) which is commonly defined as the task of answering the question “who spoke when?” in a speech recording. The first objective of the proposal is to optimize the Bayesian approach to SD, which has shown to be promising for the tasks. For Variational Bayes (VB) inference, that is very sensitive to initialization, we will develop new fast ways of obtaining a good starting point. We will also explore alternative inference methods, such as collapsed VB or collapsed Gibbs Sampling, and investigate into alternative priors similar to those introduced for Bayesian speaker recognition models. The second part of the proposal is motivated by the huge performance gains that, in recent years, have been brought to other recognition tasks by Deep Neural Networks (DNNs). In the context of SD, DNNs have been used in the computation of i-vectors, but their potential was never explored for other stages of SD. We will study ways of integrating DNNs in the different stages of SD systems. The objectives of the proposal will be achieved by theoretical work, implementation, and careful testing on real speech data. The outcomes of the project are intended not only for scientific publications, but eagerly awaited by European speech data mining industry (for example Czech Phonexia or Spanish Agnitio). The project is proposed by an excellent female researcher, Dr. Mireia Diez, having finished her thesis in the GTTS group of University of the Basque Country, one of the most important European labs dealing with speaker recognition and diarization. The proposed host is the Speech@FIT group of Brno University of Technology, with a 20-year track of top speech data mining research. The proposed research training and combination of skills of Dr. Diez and the host institution have chances to advance the state-of-the-art in speaker diarization, provide the applicant with improved career opportunities and benefit European industry.

Mots clés : speaker diarization, speaker recognition, variational bayes inference, deep neural networks, speech data mining

Participants :
- Brno University of Technology (Rép. Tchèque) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 142720.8 €
Projet WILDCAT (Horizon 2020, appel à projets 2016)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The proposed project will conduct an ethnographic study of small-scale gold mining in South America, otherwise known as ‘wildcat mining’, and aims to explore the interconnection between formal and informal economic spheres at the global margins. The project will forge a concept of ‘wildcat economics’: that is, the particular form of small-scale mining that takes place in extremely remote regions of the world essentially ‘under the radar’, in this case the Amazonian rainforest. As such, WILDCAT will explore forms of globalization that do not comprise direct corporate growth, but emerge from individual ventures, and thus challenges stereotypical renditions of resource extraction and global capitalism. Through this analytical framework, the project provides insights into lesser-understood workings of globalization by offering new ways of conceptualizing the jurisdictions of global capitalism and the economic activities that lie beyond its limits. Fieldwork will take place in the Madre de Dios region of Peru where wildcat mining activity is clustered, and will draw on methodologies of both anthropology and geography. I will significantly benefit from a placement at the University of Copenhagen as it is one of the key European centers for the study of Resource Extraction and Management. Significantly, Copenhagen University houses the Centre for Sustainable Artisanal and Small-Scale Mining (SASMin), which explores the activities and issues associated with small-scale mining around the world. I will be affiliated with this centre as a researcher representing and bringing insights from the discipline of anthropology.

Mots clés : resource extraction, small scale mining, latin america, remoteness, anthropology, amazonia

Participants :
- University of Copenhagen (Danemark) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 212194.8 €
Projet ExoMAC (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

The search for and characterization of exoplanets are among the most active and rapidly advancing fields in modern astrophysics. To date, more than 4000 exoplanets have been detected, spanning wide ranges in physical, orbital and stellar parameters, and with a great variety of system architectures. Understanding the causes of exoplanet diversity and variety is a stated goal of the next-generation of ESA/NASA missions. In this context, I propose to develop the project "Exoplanets Molecular Atmospheric Composition" (ExoMAC), together with the Instituto de Astrofisica de Canarias (IAC) under the supervision of Dr. Enric Pallé. The project consists of the following Scientific Objectives: SO1: The complete and consistent (C&C) analyses of individual planets for measuring the absolute abundances of all the main carbon and oxygen-bearing molecules, metallicity down to less than 0.5 dex and precise C/O down to 0.1 dex in a handful of exoplanet atmospheres. The C&C analyses will provide the first empirical constraints on the possible formation and evolutionary paths of exoplanets; SO2: The development of a convolutional neural network (CNN) for the automated classification of newly-released TESS light-curves for the discovery and classification of new exoplanet populations. This CNN will lead to the discovery of more than 10000 transiting exoplanets, among which to select the prime targets for spectroscopic characterization with current and next-generation facilities. The C&C analyses propose a novel approach to leverage the information obtained with multiple instruments and observing techniques through a bayesian framework. We will adopt an updated version of the TauREx code to enable consistent retrievals, coupled with deep convolutional generative adversarial networks to speed up the likelihood sampling.

Mots clés : exoplanet atmospheres, spectroscopy, consistent retrievals, bayesian statistics, neural networks

Participants :
- Instituto de Astrofísica de Canarias (Espagne) — Coordinator, beneficiary, Recherche, subvention : 160932.48 €
Projet RegARcis (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The significance of epigenetic deregulation is a very hot topic in current prostate cancer (PC) research. New mutations have been identified in several epigenetic regulators known for their interaction with the AR. In fact, the role of chromatin remodeling factors facilitating enhancer-promoter cooperation in the formation of the AR transcriptional complex has long been demonstrated. Accordingly, the marked redistribution of AR binding sites (cistrome) during tumorigenesis is arguably the most recurrent genetic or epigenetic alterations in PC. Thus, this MCSA project aims at elucidating the role of the SWI/SNF chromatin-remodeling complex in the emergence of resistance to anti-AR signaling inhibitors. This is of utmost importance as resistance to AR signaling inhibition is arguably the principle hallmark of lethal prostate cancer. To this end, I aim at (i) investigating the SWI/SNF dependent chromatin accessibility and AR cistrome; and at (ii) assessing the actionability of SWI/SNF interacting partners in castration resistance prostate cancer (CRPC). In short, this MSCA proposal will help to define the repertoire of SWI/SNF coregulators in CRPC and to determine the extent of AR cistrome remodeling to envision new therapeutic strategies and help predict treatment response.

Mots clés : prostate cancer, epigenetic deregulation, ar cistrome, snf complex, anti ar signaling inhibitors and castration resistance prostate cancer

Participants :
- Institut d'Investigació Biomédica de Bellvitge (Espagne) — Coordinator, beneficiary, Recherche, subvention : 160932.48 €
Projet HuSME (Horizon 2020, appel à projets 2019)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

The skin microbiome constitutes an attractive platform to incorporate novel functionalities to the host, due to accessible location, tight contact with the host, low immunogenicity, and easier genetic manipulation, among other reasons. I will adopt a translational synthetic biology approach to engineer the human skin commensal C. acnes (formerly P. acnes) as a disease-sensing biological device (“biodevice”) with therapeutic activity. Precisely, engineered C. acnes will detect atopic dermatitis (AD, the most common chronic inflammatory disease worldwide) and respond by producing an anti-inflammatory molecule. First, I will develop a vector and a methodology for efficient gene delivery into C. acnes. Next, I will construct synthetic gene circuits that will allow C. acnes to detect inflammatory markers in vitro and to respond by secreting anti-inflammatory signals. Finally, I will use the C. acnes biodevice as an in vivo therapeutic product: I will apply the engineered bacteria on a mouse model of AD and evaluate its potential as a therapeutic tool capable of disease-sensing and regulated maintenance of skin homeostasis. This project will contribute to the emerging field of human microbiome genetic engineering, will inspire and guide future efforts towards microbiome repurposing for therapeutics, and has the potential to provide exploitable results and better therapeutic options for AD patients.

Mots clés : translational synthetic biology, smart  engineered bacteria, programmable probiotics, human skin microbiome engineering, skin microbiome, c  acnes, p  acnes, gene circuit, atopic dermatitis

Participants :
- Pompeu Fabra University (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 160932.48 €
Projet ARTEMIS (Horizon 2020, appel à projets 2020)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Environment and Geosciences
Statut du projet : CLOSED

The smart city concept has received increased attention from researchers and decision-makers across the EU. However, there is a gap between smart city research & practice, and environmental sustainability: to date, smart city projects have not adequately assessed the environmental impacts of their strategies, which remain largely unknown. Research is needed to provide empirical evidence, advanced tools and metrics that can support the design, implementation and evaluation of smart city strategies to improve urban environmental sustainability. RESEARCH GOALS ARTEMIS will investigate whether and how the smart city can improve the environmental performance of urban systems. The research aims to provide insight on key aspects in smart city strategies that can effectively reduce environmental impacts; a novel environmental impact assessment framework to support decision-making in smart city projects; and improved key performance indicators (KPIs) on environmental sustainability and circularity for smart cities. ACHIEVING THE GOALS ARTEMIS will develop an integrated framework coupling urban metabolism and life-cycle assessment, to estimate how strategies implemented in two EU-funded smart city projects (in Lisbon, Portugal, and Trento, Italy) have affected a wide set of environmental impacts, associated with urban systems. Drawing on the framework and results, KPIs will be provided to evaluate environmental sustainability in smart cities. The framework, recommendations and KPIs will be replicable across EU cities. RELEVANCE TO THE WORK PROGRAMME ARTEMIS will support the EU’s vision for smart cities and its aim of becoming a role model in sustainable development. My expertise in environmental impact assessment and the supervisor’s in smart cities bond effectively to pursue the research plan. The fellowship is a unique opportunity for me to obtain enhanced knowledge and skills on the development of environmental assessment tools and metrics for smart cities.

Mots clés : smart city, environmental impacts, life cycle assessment  lca, urban metabolism  um, energy, greenhouse gas  ghg  emissions, key performance indicators  kpis, sustainable urban development

Participants :
- European Academy of Bolzano (Italie) — Coordinator, beneficiary, Recherche, subvention : 171473.28 €