Projet EvoMG-DN (Horizon Europe, appel à projets 2024)
Action : Doctoral Networks
Panel : Life Sciences
Statut du projet : SIGNED

The Evolutionary Medical Genomics Doctoral Network (EvoMG-DN) pioneers an integrative approach combining Evolutionary Medicine and Medical Genomics to address critical health challenges. By combining evolutionary insights with state-of-the-art genomic tools, EvoMG-DN seeks to establish EvoMG as a structured and impactful discipline in Europe. The network aims to train the next generation of interdisciplinary researchers to unlock the full potential of evolutionary genomic approaches in healthcare.  EvoMG-DN pursues three overarching objectives: (i) foster interdisciplinary synergy by uniting EvoMG researchers from diverse fields to catalyze innovation in methodologies and tools; (ii) create a cohesive training framework, equipping doctoral candidates (DCs) with expertise in EvoMG applications through structured training and collaboration; and (iii) advance evolution-informed clinical applications, such as adaptive cancer therapies.  The research program is organized into three scientific work packages: WP1 explores evolutionary insights into ageing and age-related diseases; WP2 focuses on tumor evolution and acquisition of resistance in cancer therapies; and WP3 addresses pathogen evolution, antibiotic resistance and interactions with the immune system. These are underpinned by core methodological pillars, which include comparative functional genomics, genetic diversity analysis, mathematical modeling and machine learning, and the use of unconventional model organisms.  Through interdisciplinary secondments, tailored mentoring, and advanced training modules, EvoMG-DN empowers DCs to bridge disciplines and develop actionable solutions to global health challenges. By formalizing EvoMG methodologies and advancing clinical applications, EvoMG-DN aims to solidify Europe’s leadership in biomedical research and deliver long-lasting societal impact.

Mots clés : evolutionary medicine, medical genomics, transcriptomics, adaptive cancer therapies, antimicrobial resistance, killifish, bats, cfdna, somatic mutations, alternative splicing

Participants :
- Centro de Regulación Genómica (Espagne) — Coordinator, beneficiary, Recherche, subvention : 564376.32 €
- University College Dublin (Irlande) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 341087.04 €
- Fundacio d'estudis i recerca oncologica (fero) (Espagne) — Partner, associated partner, Autres, subvention : 0.0 €
- Université Pompeu Fabra (Espagne) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 564376.32 €
- Institute of Cancer Research (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 697476.24 €
- Université polytechnique de Catalogne (Espagne) — Partner, beneficiary, Recherche, subvention : 282188.16 €
- École polytechnique Chalmers (Suède) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 324630.0 €
- Université de Barcelone (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Microomics systems s.l. (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Centre national de la recherche scientifique (France) — Partner, beneficiary, Recherche, subvention : 314669.16 €
- Université de Lisbonne (Portugal) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Mashauri limited (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Organisation européenne de biologie moléculaire (Suisse) — Partner, associated partner, Autres, subvention : 0.0 €
- Université de Cambridge (Royaume-Uni) — Partner, beneficiary, Enseignement supérieur ou secondaire, subvention : 348738.12 €
- Gulbenkian Institute for Molecular Medicine (Portugal) — Partner, beneficiary, Recherche, subvention : 558890.64 €
- Université Paris Cité (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Institut Pasteur (France) — Partner, beneficiary, Recherche, subvention : 314669.16 €
- Leibniz-Gemeinschaft (Allemagne) — Partner, beneficiary, Recherche, subvention : 290272.32 €
- Nonacus ltd (Royaume-Uni) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université Friedrich-Schiller d'Iéna (Allemagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- École normale supérieure PSL (France) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Duke (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €