Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet CatT (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Mathematics
Statut du projet : CLOSED

Outstanding problems in a variety of mathematical fields have been shown to reduce, in essence, to questions about the combinatorial structure of the transfinite; this was the case, for example, in Shelah's solution to the Whitehead Problem in group theory, Farah's solution to the Brown-Douglas-Fillmore Problem in operator algebras, Solovay and Woodin's solution to Kaplansky's Conjecture on the automatic continuity of Banach algebras, and Moore's solution to the $L$ Space Problem in general topology. At the same time, cardinality and transfinite closing-off arguments play a critical role in many of the most fundamental constructions of contemporary category theory --- in the small object argument, the themes of local presentability and accessibility, or the invocation of Grothendieck universes, for example. Considerations of this latter sort play an insistent role in the 50-year-old problem of the existence of cohomological localizations in the categories of simplicial sets or spectra, a question which the work of this application's sponsor (among others at the University of Barcelona) suggests may well turn out, much as above, to be set theoretic in essence. Work on this problem forms the core of the present proposal, both for its instrinsic interest and bearing on multiple related conjectures (Hovey's Conjecture on Bousfield classes, most prominently), and for its relation, via the phenomenon of $\kappa$-phantom maps, to the researcher's accumulating results on the higher derived limits of large inverse systems. In its course, a number of related questions, for example on the cohomology of small cardinals, will receive close attention as well. This is, in short, a proposal to bring researchers from the divergent fields of algebraic topology and set theory together for work on a well-known problem which they may be uniquely well-suited to solve, and in the process to considerably extend the lines of research for which they are already known.

Mots clés : combinatorial set theory and higher dimensions therein , derived limits, localization of categories, walks on the ordinals, borel complexity

Participants :
- Université de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet HYPOXIA (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Cellular adaptation to oxygen deficiency (hypoxia) is a complex biological process. Germline mutations occurring in the hypoxia genes pathway provided major information to dissect the molecular mechanisms regulating this pathway. The objective of HYPOXIA project is to elucidate the molecular and regulatory mechanisms governing erythropoietin (EPO) gene expression, a major actor of the hypoxia pathway. The originality of HYPOXIA lies in identifying naturally occurring germline EPO mutations in patients with hereditary erythrocytosis presenting excess red blood cells production. Recently, the host laboratory and European collaborators have identified intriguing genetic variants located in non-coding sequences of EPO in six families with erythrocytosis. Remarkably, all families exhibited normal circulating EPO levels, suggesting gain-of-function potentials of the new EPO. EPO is the hormone that regulates daily red blood cells production and its regulation greatly depends on the developmental stage, cellular type, and oxygen concentration. Given the complexity in EPO regulation, HYPOXIA aims at deciphering the expression and splicing mechanism of the newly identified EPO. I will use an innovative cellular disease model based on differentiating human induced pluripotent stem cells (hiPSCs) into different EPO-producing cells (neural crest cells and hepatocytes). The wild-type, edited, and mutant cells will then be studied using Next Generation Sequencing approaches (RNAseq and ATACseq). Besides its erythropoietic role, studies have highlighted various pleiotropic effects of EPO such as its protective role in ischemic injury and wound healing and regulation of metabolic homeostasis including gender-specific EPO response. Thus, HYPOXIA cellular model may lead to the development of new therapeutics or treatments for erythrocytosis, anemia, and other EPO-related disorders. The newly identified EPO isoforms might render this cytokine a promising game changer in human health.

Mots clés : hypoxia, erythropoietin, hereditary erythrocytosis, epo producing cells, hipscs, next generation sequencing

Participants :
- Institut national de la santé et de la recherche médicale (France) — Coordinator, beneficiary, Recherche, subvention : 225904.46 €
Projet OikoDefensome (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Intensification of the frequency and severity of harmful algae blooms (HABs) has recently increased due to climate change and global warming, affecting environment, human health as well as local economies based on fishing and/or recreational activities. Some diatom species (representing half of the primary production of the oceans) synthesize biotoxic compounds derived from secondary metabolites known as oxylipins, which are highly produced during HABs upon cell damage. Several studies have reported that Polyunsaturated aldehydes (PUAs), among the most studied oxylipins, have negative effects on many marine organisms, reporting impairment of growth, reproduction, cell homeostasis and detoxification. However, the genetic mechanisms that regulate these physiological responses are still unknown. It has been proposed that some organisms could have a set of conserved genes that will be activated upon PUAs exposure, the so call ‘Defensome’, but few members had been described. The larvacean Oikopleura dioica is one of the many organisms affected by PUAs. In addition of being among the most abundant components of the mesozooplankton, O. dioica is an “evolutionary-knockout” for many signalling pathways being a perfect candidate to study biological adaptations by gene loss. Using O. dioica as animal model we aim to identify conserved Defensome genes shared among marine animals and to study the developmental pathways affected by biotoxins. To achieve this goal, we will combine transcriptomics (RNASeq), chromatin accessibility (ATAC-Seq) and gene interference approaches (RNAi, DNAi, Cas9-CRISPR). The results of this project will be key for understanding the genetic adaptive response of marine embryos to the biotoxic impact of HABs on marine environments worldwide. Moreover, the discovery of a conserved set of Defensome genes across different groups of marine animals, could provide a useful set of pan-markers of environmental stress for be applied in many different species.


Participants :
- Stazione Zoologica Anton Dohrn (Italie) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Barcelone (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet ArcRep (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

The ability of cells to copy their genome before cell division is one of the wonders of biology. For DNA replication to succeed, multiple proteins act in concert forming a dynamic molecular engine known as the replisome. Great effort has been made to characterise all the components of the replisome, yet our understanding of how they work together to achieve DNA replication is still very limited. Recent studies have provided initial structural clues on the T7 phage, yeast and human replisomes, yet there is a large knowledge gap around the archaeal one. Furthermore, the archaeal replisome constitutes a living molecular fossil with a blend of bacterial and eukaryotic features that can help us better understand the emergence of eukaryotes.  The first aim of ArcRep is to use recent advances in cryo-electron microscopy (cryo-EM) to determine the first structure of the archaeal replisome, revealing the molecular contacts that allow it to function. The second aim is to further understand how the replisome interacts with DNA, and to assess its potential for future development of tools that harness the sophistication of nature’s replisome in a test tube, as novel single-cell genomics biotechnology.  With the cryo-EM experience I gained during my PhD, I will join the Sauguet lab to build up on their ample experience in the structure of archaeal replication proteins, and achieve the first aim of ArcRep. During a secondment in the Gardner lab (New England Biolabs, USA), who are experts in archaeal replication enzymology and have an established collaboration with the host lab, I will further characterise the replisome with methods previously developed in their group. This will achieve the second aim of ArcRep backed by a world leader in the production of reagents for life sciences.  The distinct expertise that each of the three parties brings to ArcRep is an ideal melting pot for it to succeed and for me to acquire invaluable experience in both academic and industry environments.

Mots clés : dna replication, cryo em, replisome, archaea, euryarchaea, pold, dna polymerase, helicase

Participants :
- Institut Pasteur (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
- New England Biolabs (United States) (Etats-Unis) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet MORPHEUS (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : SIGNED

MORPHEUS aims to advance the field of 2D carbon technology through the synthesis and characterization of electroactive nanoporous graphene (e-NPG). The project will utilize on-surface synthesis (OSS) to create complex graphene nanoarchitectures with atomic precision, via a 2-step OSS approach. This involves laterally interconnecting graphene nanoribbons (GNRs) using electroactive bridges that enable pore functionalization. These electroactive bridges will act as electrochemical gates through redox reactions, switching on/off the quantum electronic transport between GNRs, leading to the development of highly sensitive and selective chemical sensors. The key objectives of MORPHEUS are: - Atomically-precise synthesis of e-NPG with homogeneous nanometer-sized pores by interconnecting graphene nanoribbons (GNRs) with electroactive molecular bridges. - Controlling activation and deactivation of these bridges through site-specific redox reactions. - Characterizing the gas-sensitive electronic transport properties of e-NPG-based field-effect transistors (FETs). The innovative use of OSS for lateral interconnection of GNRs and the incorporation of electroactive bridges aims to achieve unprecedented control over electronic properties and device functionality. The project will be evaluated using mainly scanning tunneling microscopy/spectroscopy (STM/STS) and FET device performance measurements in the presence of different gases. This research is expected to provide new insights into quantum electronic transport in complex graphene nanoarchitectures and their potential use in quantum sensing, thus contributing to the expansion of atomically precise carbon-based materials in the Spanish research community, where the researcher plans to establish herself in the future.

Mots clés : on surface synthesis, nanoporous graphene, scanning tunneling microscopy, quantum transport, chemical sensors

Participants :
- Université de Cantabrie (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 194074.56 €
Projet EnvINExt (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : CLOSED

The Middle-Upper Paleolithic (MP-UP) transition is a key period for human evolution, as it corresponds to late Neanderthal’s disappearance and their replacement by Anatomically Modern Humans (AMH), after both species briefly co-occurred. This multifactorial event happened at different spatial and temporal scales across Europe. Climate constitutes a strong driver of species evolution. For Neanderthal, there is no consensus regarding the impact of climate on its disappearance, although it happened during the Marine Isotopic Stage 3, characterized by abrupt and rapid climatic oscillations. In order to track climate changes at the time of the Neanderthal’ demise and the evolutionary success of AMH, ecological proxies filling the gap between local environmental conditions and global climate changes are mandatory. Herbivore teeth are robust traps for physiological, ecological and climatic information and thus mirror past environments. EnvINExt implements three complementary ecological proxies on ungulates preyed by both human species from 10 archeological sites covering the MP-UP transition in North Iberia. Combined Dental Microwear Texture, Enamel Carbon and Oxygen stable Isotope and Molar Mesowear Analyses provide ecological information at three temporal scales, for a global overview of the paleoecology and paleoenvironment of preys and humans. EnvINExt has four objectives: (i) Exploring the ecology of ungulates, key preys for human populations, before, during and after the MP-UP transition, (ii) drawing paleoenvironmental inferences at the scale of the territories exploited by Neanderthals and AMH, (iii) thus, linking global climate changes with local environmental changes and asynchronous disappearances of Neanderthals through north Iberia during the MP-UP transition. Finally, (iv) to confront these results for northern Iberia, a refuge area, with what is obtained in southwestern France (Berlioz’s current postdoctoral work).

Mots clés : middle upper paleolithic transition neanderthal extinction paleoenvironments combined ecological proxies

Participants :
- Université de Cantabrie (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet Wide-Band Ephys (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - Global Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

Dementia is a major healthcare challenge worldwide due to its high incidence and its strong impact on the life quality of patients and on society as a whole. Development of treatments for the mitigation of memory impairment in patients with dementia has proven very challenging, partly due to our limited understanding of the underlying mechanisms of memory consolidation. Memory consolidation is mediated by communication between large-scale networks in the brain, particularly the hippocampal formation and neocortical circuits, coordinated by synchronous oscillatory dynamics, as shown in both humans and animal models during the resting state. In humans, this coordination is associated with complex resting-state network (RSN) dynamics that are reflected in spatio-temporal patterns of infra-slow (<0.5Hz) brain activity. However, the link between RSNs dynamics and well-understood neuronal dynamics underlying memory consolidation in animal models remains a major knowledge gap due to technical limitations. Wide-Band Ephys has a unique potential to close this gap by mapping extracellular potentials with high spatio-temporal resolution in a wide frequency band, enabling inference of RSN dynamics across brain-wide networks in freely moving rats. Using customized graphene-based neural probes in combination with Neuropixel 2.0 probes, fiber-photometry and optogenetics, I aim to investigate the mechanisms underlying memory consolidation with an unprecedented level of detail. Extending the current knowledge on the functional role of RSNs and local slow oscillations in the rat could lead to the development of novel treatments for dementia, which will be explored in collaboration with the private sector during this project. The interdisciplinary approach presented in this proposal will complement my expertise in neurotechnology with more advanced skills in fundamental neuroscience, enhancing my career prospects in the field of translational neuroscience.

Mots clés : active sensors, wide band, fiber photometry, closed loop, optogenetics, slow oscillations, rsn, memory consolidation

Participants :
- Conseil supérieur de la recherche scientifique (Espagne) — Coordinator, beneficiary, Recherche, subvention : 113220.6 €
- Université de New York (Etats-Unis) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Catalan Institute of Nanoscience and Nanotechnology (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Inbrain neuroelectronics sl (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
Projet COGSTIM (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Computational models of vision often address problems that have a single and definite end-point, such as visual recognition: an example of this might be to find a ripe banana in a complex scene. However, not all computation is of this form. Visual information is processed continuously in sensory areas and the nervous system has the capacity to alter or halt an ongoing behavioral response to changes in incoming information. We can therefore react flexibly to updated sensory input or changed requirements for motor output. On the other hand, these same neuronal mechanisms must also support perceptual stability, so that noisy signals do not cause loss of a crucial goal.  In project COGSTIM, I will investigate the functional neuronal networks that support the balance between perceptual flexibility and stability, within primate visual areas. I will use a highly innovative approach, combining dense electrophysiological recording with online (real-time) decoding of neuronal correlates of the subject’s perceptual choice, based on adaptive machine-learning algorithms. In order to control visual perception effectively and predictably, closed-loop electrical stimulation will be applied under dynamically adjusted feedback to identified neuronal circuits that causally modulate associated percepts. Crucially, this novel approach using joint decoding and stimulation in real time will allow me to target dynamically visual percepts, representing a significant advance in our understanding of on-going, continuous computations of the primate brain. Such developments offer promising bases for the future development of rehabilitative therapeutical protocols, as well as innovative brain machine interfaces suitable for real-world use.

Mots clés : visual perception, brain machine interface, electrophysiology, closed loop stimulation

Participants :
- Université Otto von Guericke de Magdebourg (Allemagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 173847.36 €
Projet ENGAGE-M-BREATHER (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The mental health (MH) burden of many adult cancer survivors (ACS) may persist for up to 26 years after cancer diagnosis, resulting in substantial psychosocial, professional, and economic losses. Digital mental health interventions (DMHIs) are a highly advantageous, sustainable, and state-of-the-art self-care solution for improving MH and quality-of-life of ACS. However, uptake of and adherence to DMHIs, jointly called engagement in digital self-care, is a persistent challenge in ACS. Developing more engaging DMHIs for ACS is one of the most promising solutions to tackle this challenge. Yoga-breathwork, which involves regulated breathing at one's own pace, is a good fit for many ACS as it is simple, cost- and time-effective, less intensive, evidence-based, and a self-manageable MH intervention that is scalable after digitalisation. Therefore, my MSCA-PF project, ENGAGE-M-BREATHER, aims to go beyond the state-of-the-art in digital self-care with innovative modalities for developing an engaging yoga-breath DMHI for ACS.  ENGAGE-M-BREATHER is a uniquely positioned, ambitious project, which aims to develop and test novel engagement modalities for self-management of MH and flourishing in ACS through a yoga-breath DMHI. This central aim will be fulfilled by 1) co-creating a yoga-breath DMHI, 2) evaluating it for MH outcomes and offering related data visualisation analytics, and 3) exploring biofeedback coupling with the DMHI. Moreover, this project produces direct and immediate societal and technological outcomes during the non-academic placement by offering ACS a co-created DMHI to self-manage their cancer-related fatigue through an existing mHealth app, Untire. This market translation will also build more engagement in ACS.  The interdisciplinary, international, and intersectoral exposure and training gained through this project will establish me as a leading researcher in digital MH, with the ability to form my independent research group with multinational grants.

Mots clés : wellbeing, mental health, quality of life, self management, ehealth, health promotion, digital mental health interventions, mhealth, adult cancer survivors, co creation, biofeedback, yoga breathing

Participants :
- Université de Twente (Pays-Bas) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 291145.2 €
- Tired of cancer bv (Pays-Bas) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €