Data-Gouv-ML/pcri-actions-marie-curie-participations-et-projets-laureats huggingface dataset:
Projet DESIGN-XTREME (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

The demand for materials that can withstand extreme temperatures poses a significant challenge. New energy technologies, like efficient turbines and heat exchangers, require strong materials at high temperatures. Similarly, space exploration requires durable materials at extremely low temperatures. Due to embrittlement at cryogenic temperatures and thermal instability at elevated temperatures, understanding how materials behave in such conditions is crucial. Conventional metallic materials have limits in strengthening, calling for alternative materials. Multicomponent high entropy alloys (HEAs) offer opportunities due to their potential for better strength-ductility combination. HEAs can be used to trigger multiple deformation mechanisms, breaking the strength-ductility trade-off dilemma. The proposed project focuses on understanding and optimizing refractory and precipitation-strengthened HEAs for applications under extreme temperatures (15 to 1500 K). These materials are critical for industries such as aerospace, energy, and advanced manufacturing, where durability and performance at both high and low temperatures are essential. The project aims to understand the underlying deformation mechanisms of HEAs through advanced in-situ experiments using synchrotron and neutron diffraction, combined with computational modelling. By integrating experimental findings with crystal plasticity models, the project seeks to design HEAs with superior mechanical properties, contributing to more sustainable and efficient materials for extreme environments. This research not only advances materials science but also aligns with sustainability goals by reducing the environmental impact of high-performance materials.

Mots clés : metallic materials mechanical behavior extreme temperatures

Participants :
- UK Research and Innovation (Royaume-Uni) — Partner, associated partner, Recherche, subvention : 0.0 €
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 209914.56 €
Projet SMARTBATT (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : CLOSED

Despite significant advancement in other characteristic requirements of rechargeable lithium-ion batteries (LIBs), safety threats to the rechargeable LIBs still persist. Main challenge of the safety concerns related to LIBs is heat accumulation during thermal runaway inside the cells, which is difficult to be eliminated due to poor thermal management associated with current technologies. In this context, the overarching aim of this ambitious yet achievable project (SMARTBATT) is to develop a thermoreversible liquid-solid transition (TLST) electrolyte integrated with inherent flame-retardancy for LIBs. The new idea of SMARTBATT is to design and synthesis flame-retardant thermoreversible liquid-solid transition electrolytes via the principals of the chemical Michael addition reaction (to incorporate flame retardant into electrolytes) and chemical Diels-Alder addition reaction (to produce liquid-solid transition in the electrolytes). In details, TLST will be comprised of Li-salt dissolved in a mixture of two organic solvents-vinylene carbonate and 2,5-dimethylfuran; as internal temperature of LIBs increases, both organic solvents will undergo a Diels-Alder addition reaction to form a supramolecular crosslinked network, as a result there will be a significant diminution in Li+ ion conductivity, led LIBs to non-operational mode. Moreover, TLST functionalized with 9,10-Dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) will offer excellent flame-retardancy to the electrolytes as fire hazard of LIBs appears. SMARTBATT is multidisciplinary and requires complementary expertise from the host (Polymer Chemistry and Physics, Fire Retardant Materials) and the researcher (Electrochemistry, Battery), is contributing to the new generation of LIBs, following the priorities of the Europe 2020 Strategy regarding reaching a Smart, Sustainable and inclusive growth and European BATTERY 2030+, and aligned with some specific priorities of Cluster 5 Framework Programme Horizon Europe.

Mots clés : fire retardant materials, fire safe batteries, smart electrolytes, diels alder reaction, thermoreversible liquid solid transition type electrolytes, smart batteries

Participants :
- Madrid Institute for Advanced Studies (Espagne) — Coordinator, beneficiary, Recherche, subvention : 181152.96 €
Projet FOX-mTN (Horizon Europe, appel à projets 2021)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : CLOSED

Ageing is the result of accumulated cellular dysfunction and loss of tissue homeostasis, which often leads to the emergence of age-related pathologies such as cancer and cardiovascular disorders. The disruption of tissue homeostasis during ageing is particularly critical in the case of the vascular endothelium. The signaling interface and barrier to external factors is provided by a single layer of endothelial cells in a quiescent state. The maintenance of this quiescent state plays an important role in vascular aging and development of cardiovascular diseases. Previous studies have shown that the FOXO1 is a critical driver of endothelial quiescence, where its loss and overexpression leads to vascular overgrowth and rarefaction, respectively. My preliminary analyses show that gene expression levels of FOXO family varies in aged-tissues and that FOXO1/3/4 mutant mice display significant vascular malformation in the retina. On the other hand, ageing is associated with an increase of transcriptional noise and accumulation of aberrant RNA, which if not eliminated, may lead to cellular dysfunction. My preliminary data shows that even healthy tissues have significant levels of transcriptional noise, while old individuals present higher levels of such aberrant transcription. However, transcription noise is an unexplored phenomenon impacting cell homeostasis. In addition, my analyses also show that FOXO1 overexpression in cultured human endothelial cells leads to higher levels of transcription noise. Given the accumulating evidence and my preliminary findings, I propose to explore how the dysregulation of FOXO transcription factors increases transcription noise, promoting functional decline of the vascular endothelium through ageing. Understanding the cascade events that drive this transcription aberrancy can have a significant impact on the prevention of cellular function decline and delay a wide range of ageing illnesses.

Mots clés : transcription noise, ageing, foxo, vascular endothelium, bioinformatics

Participants :
- Université nouvelle de Lisbonne (Portugal) — Coordinator, beneficiary, Recherche, subvention : 156778.56 €
Projet ProMatEx-NS (Horizon Europe, appel à projets 2022)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Physics
Statut du projet : CLOSED

In this proposal, we will probe the properties of nuclear matter at extreme conditions of pressure and gravity using neutron stars as astrophysical laboratories. We will study different aspects of neutron stars: from the outermost part to their dense core. We will test the latest theories in nuclear physics and develop a robust understanding of its interior using the latest observational data and the results from nuclear experiments relevant to the matter of the neutron star core. We will create a relativistic nuclear metamodel to model the neutron star matter that can incorporate present and future experimental uncertainties. With this understanding, we will use neutron stars as dark matter detectors and test theories of particle physics beyond the standard model. We will predict the detectability of dark matter in future space-based missions and gravitational wave detectors.

Mots clés : neutron stars, dense matter, quark matter, hybrid stars, pulsars, gravitational waves, binary merger, dark matter, 

Participants :
- Université de Salamanque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 165312.96 €
Projet GPSpace (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : TERMINATED

The GPSpace project will address the use of graphene-based materials in solar cells for space applications, aiming to improve the stability of device architectures against the harsh environment in space. This research will evaluate the performance of graphene nanomaterials as electrodes and as interfacial layers regarding ultraviolet (UV) stability of metal halide perovskite solar cells under high vacuum. Additionally, this approach will contribute to the development of lightweight solar cells architectures with high specific power (EPw).

Mots clés : perovskite solar cells, graphene, interface engineering, inorganic and organic chemistry, space based solar power

Participants :
- Graphenea (Spain) (Espagne) — Partner, associated partner, Organismes privés (hors enseignement), subvention : 0.0 €
- Université de Salamanque (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €
Projet Cat4Arene (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

In the last 20 years, palladium-catalyzed C–H activation has emerged as a useful alternative to traditional cross-coupling methods and a powerful tool to access valuable intermediates for the synthesis of complex functional molecules. The biaryl fragment is one of the most frequent units present in bioactive molecules, functional organic materials and natural products. Despite major advances, significant limitations persist with regard to their preparation, in term of reactivity, selectivity and sustainability. Based on the recent achievements in the synthesis of ortho-iodobiaryls following a Catellani strategy, the overall objective of this proposal is the development of a general and sustainable method for the direct synthesis of ortho-iodobiaryls and selectively substituted haloarenes as valuable intermediates for the synthesis of a large number of high value-added compounds. The project aims also to develop protocols for the straightforward synthesis of new biaryl-containing phosphines, as a valuable application of this methodology. CAT4Arene will allow the selective construction of halogenated biaryls and arenes which can be further easily converted into a broad variety of high value-added compounds. In particular, thanks to the easily manipulation of the C-halogen bond, especially C-I and C-Br bonds, these new methodologies will unlock the direct construction of tricky molecular architectures, including biaryl-containing phosphines and bioactive nitrogen derivatives. Likewise, new classes of organic molecules would be also accessed, unlocking the opportunity to enlarge the range of compounds available for the medicinal chemistry and the agrochemical industry. The development of unconventional haloarenes formation protocols will be an outstanding breakthrough for the organic chemistry community.

Mots clés : catellani reactions, palladium, c c catalytic couplings, iodoarenes, biaryls

Participants :
- Université d'Amsterdam (Pays-Bas) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université de Parme (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 188590.08 €
Projet mRNPcode (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Life Sciences
Statut du projet : SIGNED

mRNAs are packed with RNA binding proteins (RBPs) to assemble the messenger ribonucleoprotein particles (mRNPs). Proper mRNP biogenesis, export, localization, translation, and decay are central for gene expression regulation. Each step requires specific RBPs mediating transcript interactions with the cellular machinery. So far, hundreds of RBPs have been identified begging the question of mRNP assembly diversity. While canonical RBPs are associated with all transcripts, some may be accessory, concurrent, and specific for subclasses of mRNAs. What finetunes mRNP compositions is not clear and understanding how specific mRNP compositions control mRNA fate is a major challenge for RNA biology. mRNA localization and regulated translation are believed to be mechanisms to delimit gene expression to cellular sub-compartments ensuring that proteins are synthesized where they complete their functions. Furthermore, some mRNAs display heterogeneous translation efficiencies depending on their localization in cells. mRNA localization and translation heterogeneity appear to be highly dynamic and can be fine-tuned upon cell differentiation, or during stress. These phenomena seem crucial during development, particularly for large syncytial cells such as Drosophila embryos but their prevalence and functions are not understood. We hypothesize that mRNA localization and translation kinetics are encoded by the different combinations of RBPs assembling the mRNPs. We aim to decipher the link between mRNP composition, localization, and translation heterogeneity for key mRNAs controlling embryonic patterning in Drosophila embryos. The mRNPcode project will combine mRNP capture, proteomic, and cutting-edge microscopy for single particle tracking and translation imaging to build a dynamic picture of mRNP composition, localization, and translation. The project tackles long-lasting questions beyond the Drosophila developmental field by exploring mRNP assembly and its imprinting on mRNA fates.

Mots clés : mrna, messenger ribonucleoprotein particles mrnps , rna binding protein, mrna localization, translation, localized translation, translation kinetic, proteomic, mrna tracking, translation imaging

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 211754.88 €
Projet MS-GMT (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Annually, the world generates over 62 million tonnes of electronic waste (e-waste), which contains metals (e.g. lead, mercury, cadmium), which, if not properly managed, can leach into the environment, contaminating soil, water, and air. This situation poses a significant risk to human health and ecosystems, necessitating innovative recycling measures. So far, hydrometallurgical processes for metal recovery have made strides in addressing these issues. However, challenges such as their sustainability approaches, storage capacity, high energy costs, and scalability are problematic, leading to an urgent need for new solutions. The use of magnetotactic bacteria (MTB) represents an alternative low-carbon route for metal recovery, as they can uptake and store large amounts of metals in the form of magnetosomes, (magnetic nanoparticles that can be doped with a variety of metals for superior biotechnology applications) and biosorb a wide range of metals on the bacterial membrane. However, MTB are typically cultivated using off-the-shelf bioreactors as a one-fit-all system, with sparging hydrodynamics significantly limiting microbial growth as they require tightly controlled microaerobic conditions. Therefore, this interdisciplinary project aims to develop, optimize and scale up a sustainable biomanufacturing strategy (via enhancing production performance) for MTB growth using e-waste with a novel bioreactor design. This aim successfully addresses a significant environmental problem with a low-energy, sustainable process. Overall, the developed technology will create industrial potential for its utilisation in other applicable processes, such as the health sector. This project will have a great social and economic impact in Europe by contributing to reaching Net Zero and the Green Deal targets by 2050 while advancing bionanotechnologies. It also has the potential to create new business models and technology development while promoting circular bioeconomy principles.

Mots clés : bioreactor design, computational fluid dynamics, particle image velocimetry, fermentation, magnetosome production, environmental impact assessment

Participants :
- Université autonome de Barcelone (Espagne) — Partner, associated partner, Enseignement supérieur ou secondaire, subvention : 0.0 €
- Université Aston (Royaume-Uni) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 260347.92 €
Projet ThioShowcase (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Chemistry
Statut du projet : SIGNED

Chemoselective functionalisation of peptides and bio-conjugation of proteins has led to great advances in the synthesis of clinically relevant biomolecules and our understanding of cellular processes. Thiophenylalanine represents an interesting handle owing to the increased acidity of the aryl thiol which would mean a higher percentage of reactive thiolate would persist even at physiological pH, allowing chemoselective reactions to be performed. Despite the interesting qualities of the residue, there is a notable gap in its use in peptide and protein chemistry which can be attributed to the difficult and harsh conditions required involved in the synthesis, often incompatible with common protecting groups. Herein, we exploit a mild, palladium catalysed method to obtain Fmoc-SPhe(Trt) in one step from commercially available reagents to fully explore the possibilities of incorporating the building block into peptide and protein synthesis. Namely, we will demonstrate the use of SPhe 1) as a chemoselective method for peptide stapling, 2) to perform on-resin selective disulfide formation and attempt a regioselective one-pot double disulfide formation of a novel antimicrobial peptide, 3) as a method for discretely labelling protein residues through affinity-binding proximal transfer and 4) in the form of other aryl thiol building blocks to expand the scope of this work. The development of a novel handle for bioconjugation will have an immense impact on the field of chemical biology and provide a tool for peptide analogue synthesis and elucidation of cellular processes.

Mots clés : peptide methodology, peptide stapling, organic chemistry, protein labelling

Participants :
- Centre national de la recherche scientifique (France) — Coordinator, beneficiary, Recherche, subvention : 195914.88 €
Projet TWISTY (Horizon Europe, appel à projets 2024)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Social Sciences and Humanities
Statut du projet : SIGNED

The transition from school to the labour market is a significant milestone in every person's life, marking the path to adulthood, career, and independence. However, this transition may pose challenges for youth, leading them to unemployment. Such experiences not only create economic imbalances in labour markets and increase social tension but also have long-lasting effects on individual well-being. Despite ongoing EU and global efforts, such as the 2020 Recommendation on Bridge to Jobs and SDGs 4 and 8, many young people face difficulties in securing stable employment, especially endangered is youth with vocational qualifications. Existing policies, addressing economic indicators of labour markets, often leave unaddressed real experiences of youth and how national systems of school-to-work transition (STWT) shape these experiences. The project “School-to-Work Transition of Youth with Vocational Qualifications: Cases of Germany and Italy” (TWISTY) addresses these gaps by focusing on biographies of young people navigating or finishing their transitions to stable employment. The project’s novelty lies in contrasting these experiences with policy narratives, identifying mismatches and disclosing overlooked factors in current practices. It focuses on Germany and Italy because despite political, social and economic similarities, they demonstrate astonishing differences in youth unemployment and organisation of STWT systems. Through the policy analysis and study of individual experiences, TWISTY will offer bottom-up solutions to improve STWT strategies. The findings will not only fill in the gaps in understanding of personal trajectories of skilled youth to stable employment in complicated STWT systems but also inform more nuanced policy recommendations that can be adapted to other contexts with similar socio-economic conditions. The project aligns with the EU policies on integrating young people into the labour market and contributes to the achievement of SDGs.

Mots clés : school to work transition stwt vocational education and training vet personal trajectories cross national comparison

Participants :
- Université de Bergame (Italie) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 209483.28 €
Projet MESMODI-BCG (Horizon Europe, appel à projets 2023)
Action : Postdoctoral Fellowships - European Fellowships
Panel : Information Science and Engineering
Statut du projet : SIGNED

Clinical monitoring of the heart health of stroke patients is usually done by electrocardiogram (ECG) recording, a non-invasive method that requires electrodes in contact with the patient's skin to obtain the signal. However, since specialists are required to place the electrodes, its use is restrictive. Contactless alternatives for study of heart conditions in less restrictive way have been investigated for decades. This project aims to develop novel, non-invasive methods for detecting cardiac and non-cardiac disease in stroke patients using the ballistocardiogram (BCG) signal, allowing for patient monitoring without transfer to clinical settings. The objective of the project is to answer important questions in current research in biomedical engineering, such as whether the resolution of a BCG is sufficient for the detection of cardiac conditions and whether it can become the preferred method for monitoring heart health from home. To achieve this objective, the project proposes the development of a portable prototype for the acquisition of BCG signals, as well as the development of novel algorithms that allow for the detection and classification of cardiac arrhythmias and episodes of sleep apnea from these signals. The project will be based on three different stages: design and implementation of the prototype, obtaining new diagnostic support algorithms based on ballistocardiogram signals, and the connection strategy at the prototype to deliver the information to the specialist doctors. This is a multidisciplinary project that combines expertise in bioengineering, health sciences, electronics, and telecommunications. This proposal also aims to transfer knowledge to the host institution and provide training for the candidate in advanced techniques. The results have the potential to significantly improve the capacity of home health monitoring and the application of eHealth knowledge. This project is aligned with the EU strategy for the protection of human health.

Mots clés : biomedical engineering, ehealth, stroke monitoring

Participants :
- Instituto de Investigación Sanitaria Aragón (Espagne) — Partner, associated partner, Recherche, subvention : 0.0 €
- Université de Saragosse (Espagne) — Coordinator, beneficiary, Enseignement supérieur ou secondaire, subvention : 181152.96 €