Projet ANR-07-BLAN-0302 – PARTICART : Nanostructured polymers as drug carriers for cartilage repair and engineering
Programme : Blanc (BLANC) 2007
Année de financement : 2007
Coordinateur du projet : CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION REGIONALE CENTRE-EST (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - DELEGATION REGIONALE CENTRE-EST)
Partenaires : Centre national de la recherche scientifique; Centre national de la recherche scientifique; TPE
Montant : 380000.0 euros
Date de début : 2007
Durée : 36 mois
Résumé : This project which associates polymer chemists/physico-chemists, biologists and manufacturers concerns design and synthesis of new nanoparticulate polymeric carriers, injectable in a cartilage defect and allowing a targeted drug delivery in chondrocytes or synoviocytes, for treatment of articular diseases. The present study has the following goals: - to synthesize, in liquid or supercritical phase, of nanosized particle systems, based on functional, biocompatible and (bio)degradable polymers - to evidence the targeting of the nanospheres to cartilage cells, using particles labelled with fluorescent probes - to encapsulate active molecules (e.g. corticosteroids, chondroprotecting glycosaminoglycans)  to thoroughly assess the biological properties. In fact, the mid term goal of this research program is to develop new formulations with various advantages: a targeted sustained release of active agents in the articular joint, the decrease of undesired side-effects due to high concentrations of anti-inflammatory/analgesic drugs, so as to limit the number of injections... The general aim is to draw, from the results of the biological assessment, relevant parameters (particle composition, morphology and size, nature of active molecules...) to treat articular diseases in order to be able to fit the nanosystem to be used, to each pathology. At longer term, one could also reconsider the use of certain new molecules, so far disregarded owing to their strong undesirable side-effects or their lack of tissular selectivity.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 ...