Levosimendan to prevent acute organ dysfunction in sepsis: the LeoPARDS RCT
Journal: Efficacy and Mechanism Evaluation
Year: 2018

Background In septic shock, cardiovascular resuscitation using catecholamine vasopressors and inotropes is standard therapy, but catecholamines have important side effects. Levosimendan (Simdax ® ; Orion Pharma, Newbury, UK) is a calcium-sensitising drug with inotropic and other properties that may have a role in sepsis. Objectives To determine, in adult septic shock, whether or not levosimendan reduces the incidence and severity of acute organ dysfunction, the effect of levosimendan on individu