Paeonol Improves Cardiac Remodelling in <scp>MI</scp> Mice by Suppressing <scp>NOX2 mRNA</scp> Expression to Mitigate Oxidative Stress and Mitochondrial Dysfunction
Journal: Journal of Cellular and Molecular Medicine
Year: 2025

Myocardial infarction (MI), a primary contributor to mortality from cardiovascular diseases, continues to pose a significant challenge in clinical treatment. In this study, our objective was to investigate the cardioprotective effects of paeonol (PAE) on mice with MI, and to delve into the precise mechanisms underlying these effects. We developed the MI model by ligating the left anterior descending artery in mice and replicated this model in vitro by stimulating H9C2 cells with levarterenol (LN