The oldest case of lymphoma? Insights from a XIII century fresco
Journal: British Journal of Haematology
Year: 2023

A fresco painted by an unknown artist in the mid XIII century and displayed in the “Gothic Hall” of the Four Crowned Saints' seclusion cloister in Rome (left panel) is interesting not only for its undisputed beauty, but also for a possible clinical enigma that can be seen on careful examination. The fresco shows a young woman with a readily detectable swollen area (roughly of walnut size) in the right cervical part of her neck (shown in higher magnification in the right panel). In the absence of