PDX MODEL OF BC IN THE STUDY OF PLASTICITY OF TUMOR CELLS IN THE PROCESS OF METASTASIZING
Journal: Cardiometry
Year: 2022

Mouse models using primary patient’s tumors (patient-derived xenograft, PDX) are an effective tool for studying the mechanisms of metastasizing. Tumor plasticity, i.e. the phenomenon of cell phenotype change in response to dynamic microenvironmental conditions is one of the key processes basic to metastasizing.