Study of the influence of pH on the conformation of a modified aptamer to nucleolin protein
Journal: Биофизика
Year: 2023

The search for agents for targeted delivery of anticancer drugs remains a crucial challenge for medicine. For this reason, DNA aptamers targeting cancer cell-specific proteins have medical use. At the same time, the additional fine-tuning of aptamer properties to lower affinity of aptamers for target cells that are not surrounding cancerous tissues makes the aptamers promising tools in clinical applications due to reduced immunogenicity and fewer side effects. One of the approaches is to use aci