Tinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD
Journal: BMC Evolutionary Biology
Year: 2015

These results suggest that the newly evolved A isoform enables modulating EDA signaling in specific conditions and with different dynamics. We speculate that during mammal diversification, A isoform regulation may have evolved rapidly, accompanying and possibly supporting the diversity of ectodermal appendages, while B isoform may have ensured essential roles. This study makes the case to pay greater attention to mosaic loss of evolutionarily speaking "young" isoforms as an important mechanism u