Myocardial Interstitial Matrix as Novel Target for Succinic Acid Treatment Strategies during Experimental Hypobaric Hypoxia
Journal: Preprints.org
Year: 2018

The myocardial extracellular matrix is not a passive entity, but rather a complex and dynamic microenvironment which represents an important structural and signaling system within the myocardium. Understanding the fundamental role of hypoxia and peroxidation in the genesis of many cardiovascular diseases has stimulated the development of strategies that can enhance the energy-producing functions of cells. Revealing the alterations in cardiac metabolism and function associated with sustained expo