COMPONENTS OF ANTITUMOR EXTRACT OF GRATIOLA OFFICINALIS LEAD TO TUMOR CELL DEATH BY APOPTOSIS DUE TO NEGATIVE REGULATION OF MCL-1 PROTEIN
Journal: Cardiometry
Year: 2023

Escape from cell death is one of the most prominent features of tumor cells and is closely related to the dysregulation of Bcl-2 family proteins. Among them, the anti-apoptotic protein Mcl-1 (myeloid cell leukaemia-1) acts as a master regulator of apoptosis in various human malignancies. The Mcl-1 -1 protein, whose main function is to protect tumor cells from apoptosis, is not the only product of the anti-apoptotic gene MCL1. On the contrary, another product of this gene, the shortened Mcl-1S pr