Післяопераційна аналгезія: роль поліморфізму 118A>G гена μ 1 -опіоїдних рецепторів (OPRM1)
Year: 2013

The evaluation of the prevalence of OPRM1 118A>G single nucleotide polymorphism (SNP) in the Crimea and its influence on the pain intensity after surgery and patients psychological state has been conducted. It has been determined that in the group of the mutant allele AG/GG carriers the severity of sleep disorder associated with pain within the first day after surgery and requirements of additional analgesia were significantly higher compared with wild allele AA carriers (p G and patients preope