The crucial role of nucleoprotein in designing a protective vaccine and precision diagnosis for Crimean-Congo hemorrhagic fever virus
Journal: Romanian Journal of Military Medicine
Year: 2026

Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic agent that causes severe hemorrhagic disease with high mortality. Outbreak control requires rapid and accurate diagnosis together with effective vaccination strategies. The nucleoprotein (NP) is a central component of viral replication and of innate and adaptive immune responses, making it a promising target for diagnostic and vaccine development. NP is highly conserved across CCHFV isolates, which supports broad molecular and