Cytotoxicity and Proapoptotic Effects of <i>Allium atroviolaceum</i> Flower Extract by Modulating Cell Cycle Arrest and Caspase‐Dependent and <i>p53</i>‐Independent Pathway in Breast Cancer Cell Lines
Journal: Evidence-based Complementary and Alternative Medicine
Year: 2017

Breast cancer is the second leading cause of cancer death among women and despite significant advances in therapy, it remains a critical health problem worldwide. <i>Allium atroviolaceum</i> is an herbaceous plant, with limited information about the therapeutic capability. We aimed to study the anticancer effect of flower extract and the mechanisms of action in MCF-7 and MDA-MB-231. The extract inhibits the proliferation of the cells in a time- and dose-dependent manner. The underlying mechanism