Recent developments in quercetin nanomedicine and applications in osteoarthritis and rheumatoid arthritis therapies
Journal: Frontiers in Pharmacology
Year: 2026

Quercetin has attracted increasing attention in the research of treatments for rheumatoid arthritis and osteoarthritis due to its excellent anti-inflammatory, antioxidant, and joint-protective effects. However, the bioavailability of quercetin is relatively low, primarily due to its poor solubility, rapid metabolism, and high clearance rate. Nanotechnology offers new opportunities to enhance the bioavailability of quercetin. Nanoformulations possess many advantages, such as a larger surface area