SYNTHESIS AND POTENTIAL BIOLOGICAL ACTIVITY OF ANALOGUES OF THE DIBAZOL
Journal: Scientific Notes of V I Vernadsky Crimean Federal University Biology Chemistry
Year: 2024

The synthesis of benzimidazole derivatives, similar to dibazole, was carried out using two methods. According to the first, 1, 2-Phenylenediamine condensed with excess quantity of 2-chlorophenylacetic acid in the presence of orthoboric acid at a temperature of 150 °C. After treatment and crystallization, the yield of 2-(2-chlorobenzyl)-1H-benzimidazole was 36 %. In the second method, 1, 2-phenylenediamine was reacted with an excess of phenoxyacetic acid and 1-naphthylacetic acid in the presence