Preventive effect of Ninjin-yoei-to, a Kampo medicine, on amyloid β&lt;sub&gt;1-42&lt;/sub&gt;-induced neurodegeneration via intracellular Zn&lt;sup&gt;2+&lt;/sup&gt; toxicity in the dentate gyrus
Journal: EXPERIMENTAL ANIMALS
Year: 2021

Ninjin-yoei-to (NYT), a Kampo medicine, has ameliorative effects on cognitive dysfunction via enhancing cholinergic neuron activity. To explore an efficacy of NYT administration for prevention and cure of Alzheimer's disease, here we examined the effect of NYT on amyloid β<sub>1-42</sub> (Aβ<sub>1-42</sub>)-induced neurodegeneration in the dentate gyrus. A diet containing 3% NYT was administered to mice for 2 weeks and human Aβ<sub>1-42</sub> was intracerebroventricularly injected. Neurodegenera