PECULIARITIES OF SALICYLIC ACID AND ASPIRIN BINDING TO ACID-SENSITIVE ION CHANNELS OF TRICHOPLAX ADHAERENS
Journal: Russian Journal of Biological Physics and Chemisrty
Year: 2022

Acid-sensitive ion channels (ASICs) represent a family of membrane three subunits' DEG/ENaC proteins that transport Na+ ions and are found in representatives of many taxonomic groups [1]. DEG/EnaC channels include such structural domains as the palm, β-ball, knuckle, finger, thumb and wrist [2]. They are involved in many physiological processes as proton-regulated channels, when the pH of the extracellular environment changes [3]. DEG/ENaC channels are associated with a wide range of cellular fu