The Role Of Apelin And Protamine Sulphate In Bile Duct Ligation Induced Liver Fibrosis In Rats
Journal: Research Square
Year: 2022

Abstract Purpose: This study was designed to investigate the effectiveness of protamine sulphate as an apelin receptor blocker on cholestatic liver fibrosis persuaded by common bile duct ligation (BDL) in experimental rats and examine some related mechanisms. Methods: Three groups of adult male Wistar rats were included: control (sham-operated), BDL and BDL+ protamine sulphate groups. All groups were examined after 4 weeks for serum apelin, total bilirubin, aspartate aminotransferase (AST), alan