Journal: Saratov Medical Journal
Year: 2024

Objective: to identify the role of rs9594738 and rs9594759 polymorphisms of the TNFSF11 gene in the development of osteoarthritis (OA) of the knee joints (KJ) in postmenopausal women.Materials and Methods.Our case-control study involved 483 postmenopausal women.Of these, 157 were diagnosed with primary KJ OA.The remaining 326 women without signs of joint disease were included in the control group.Molecular genetic studies included the determination of rs9594738 and rs9594759 polymorphisms of the