Acute brain slice elastic modulus decreases over time
Journal: Research Square
Year: 2023

Abstract A common benchmark in the brain tissue mechanics literature is that the properties of acute brain slices should be measured within 8 hours of the experimental animal being sacrificed. The core assumption is that — since there is no substantial protein degradation during this time — there will be no change to elastic modulus. This assumption overlooks the possibility of other effects (such as osmotic swelling) that may influence the mechanical properties of the tissue. To achieve consist