ASSESSMENT OF THE PROGNOSTIC POTENTIAL OF EXPRESSION AND ABERRATIONS IN THE NUMBER OF DNA COPIES OF THE HOMOLOGICAL RECOMBINATION SYSTEM GENES IN PATIENTS WITH NON-SMALL CELL LUNG CANCER
Journal: Cardiometry
Year: 2023

Numerous studies have shown that the presence of homologous recombination deficiency (HRD) in breast tumors may be a good marker of the effectiveness of chemotherapy with DNA-damaging agents such as platinum-based and anthracycline-containing medication regimens. However, the formation of HRD due to disruptions in the BRCA1/2 genes is typical not only for breast cancer and ovarian cancer, but also for other cancer localizations, in particular for non-small cell lung cancer (NSCLC). Since the use