MOLECULAR MECHANISMS OF HYPERTENSION-INDUCED HEART FAILURE Experimental studies with special emphasis on local renin-angiotensin system, cardiac metabolism and levosimendan
Journal: Työväentutkimus Vuosikirja
Year: 2011

Hypertension is a major risk factor for stroke, ischaemic heart disease, and the development of heart failure. Hypertension-induced heart failure is usually preceded by the development of left ventricular hypertrophy (LVH), which represents an adaptive and compensatory response to the increased cardiac workload. Biomechanical stress and neurohumoral activation are the most important triggers of pathologic hypertrophy and the transition of cardiac hypertrophy to heart failure. Non-clinical and cl