Formation and participation of nano-amyloids in pathogenesis of Alzheimer's disease and other amyloidogenic diseases
Journal: Biomeditsinskaya Khimiya
Year: 2010

Studies of neurodegenetrative disorders have become particularly actual attracting the attention of researchers from over the world because of the dissemination of Alzheimer's disease. The reason for such pathogenesis is the transition of a "healthy" molecule or peptide from the native conformation into a very stable "pathological" isoform. During this, molecules in the "pathological" conformation aggregate, forming amyloid fibrils that can increase without any control. Novel knowledge is requir