Circadian developmental rhythms of the experimental paracetamol hepatitis and the effect of hepatoprotectors on the activity of pro-oxidative / antioxidant and cytolytic processes
Journal: Clinical pharmacy
Year: 2019

One of the current trends in modern experimental and clinical pharmacology is determination of the dependence of the effectiveness and toxicity of drugs on the time of day or season of the year.Aim. To determine the characteristics of circadian rhythms of modern hepatoprotectors on the balance of antioxidant / prooxidant processes and the activity of cytolysis under conditions of acute paracetamol hepatitis in rats.Materials and methods. Acute toxic hepatitis was caused by a single oral administ