The extent of B‐cell activation and dysfunction preceding lymphoma development in <scp>HIV</scp>‐positive people
Journal: HIV Medicine
Year: 2017

Objectives B‐cell dysfunction and activation are thought to contribute to lymphoma development in HIV ‐positive people; however, the mechanisms are not well understood. We investigated levels of several markers of B‐cell dysfunction [free light chain ( FLC )‐ κ , FLC ‐ λ , immunoglobulin G (IgG), IgA, IgM and IgD] prior to lymphoma diagnosis in HIV ‐positive people. Methods A nested matched case–control study was carried out within the Euro SIDA cohort, including 73 HIV ‐positive people with lym