Role of сathepsin G in pathogenesis of chronic obstructive lung disease: possible ways of regulation
Journal: Medical Immunology (Russia)
Year: 2020

This review article presents the literature data supporting an idea on the role of serine proteases, and, especially, cathepsin G (CG), in pathogenesis of chronic obstructive pulmonary disease (COPD). Most studies show that the imbalance in protease-antiprotease systems in COPD is one of the main factors in the disease progression and deterioration of patient’s prognosis. CG seems to act simultaneously in several main pathogenetic aspects of the disease: it stimulates inflammation in the bronchi