Inhibition of Clostridioides difficile toxins TcdA and TcdB by the amiodarone derivative dronedarone
Journal: Naunyn-Schmiedeberg s Archives of Pharmacology
Year: 2024

The dreaded nosocomial pathogen Clostridioides difficile causes diarrhea and severe inflammation of the colon, especially after the use of certain antibiotics. The bacterium releases two deleterious toxins, TcdA and TcdB, into the gut, which are mainly responsible for the symptoms of C. difficile-associated diseases (CDADs). Both toxins are capable of entering independently into various host cells, e.g., intestinal epithelial cells, where they mono-O-glucosylate and inactivate Rho and/or Ras GTP