SCREENING FOR THE HOMOZYGOUS C.144DELC MUTATION IN AURKC GENE IN ALGERIAN INFERTILE MEN
Journal: Asian Journal of Pharmaceutical and Clinical Research
Year: 2018

Objective: Male infertility is a major health problem worldwide. Despite recent advances, the etiopathogenesis of spermatogenic failure remains largely uncertain. Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA), Aurora B (AURKB), and Aurora C (AURKC), are essential kinases for cell division through regulating mitosis and meiosis. The aim of this study was to investigate the frequency of c.144delC mutation in AURKC gene in infertile Algerian patients with abno