Improving the protective effects of aFGF for peripheral nerve injury repair using sulfated chitooligosaccharides
Journal: Asian Journal of Pharmaceutical Sciences
Year: 2018

Injury to the peripheral nerves can result in temporary or life-long neuronal dysfunction and subsequent economic or social disability. Acidic fibroblast growth factor (aFGF) promotes the growth and survival of neurons and is a possible treatment for peripheral nerve injury. Yet, the actual therapeutic utility of aFGF is limited by its short half-life and instability <i>in vivo</i>. In the present study, we prepared sulfated chitooligosaccharides (SCOS), which have heparin-like properties, to im