RESOLVIN E1 SUPPRESSES THE ALVEOLAR BONE LOSS AND INFLAMMATION IN EXPERIMENTAL PERIODONTITIS: IMMUNOHISTOCHEMICAL AND MOLECULAR GENETIC EVIDENCES
Journal: BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY
Year: 2025

Background: Periodontitis is a chronic immune-inflammatory disease associated with microbial dysbiosis and dysregulated host response, leading to irreversible destruction of the periodontal apparatus and alveolar bone. Conventional treatments primarily target bacterial reduction but do not actively resolve inflammation or restore tissue homeostasis. Specialized pro-resolving mediators (SPMs), such as resolvin E1 (RvE1), derived from omega-3 fatty acids, have emerged as potent modulators of infla