THE INFLUENCE OF A PERIPHERAL TUMOR ON THE BEHAVIOR OF ANIMALS AND THE STRUCTURE OF NEURONS IN THE PREFRONTAL CORTEX
Journal: Cardiometry
Year: 2023

Melanoma is the most aggressive of the common forms of skin cancer. Proinflammatory cytokines produced by the tumor and delivered via the circulatory and lymphatic systems can lead to damage to the structures of the central nervous system. Damage to the blood-brain barrier and the endothelium of blood capillaries can cause dysfunction of neurons in the cerebral cortex, induce changes in neural plasticity, cognitive functions and result in the development of depression. Depression is observed in