Gene-environment interplay of extreme anxiety-related behavior
Journal: Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)
Year: 2014

The use of selectively bred mouse models of enhanced fear and/or anxiety-related behavior provides a unique opportunity to identify genetic targets that contribute to pathological anxiety. However, dealing with animal models needs accurate information about their phenotypes. Accordingly, high (HAB), normal (NAB) and low (LAB) anxiety-related behavior mice – a validated model of anxiety disorders - were repeatedly tested in a variety of behavioral paradigms. Whereas most tests to assess anxiety t