Structural and cellular biology of the nairovirus nucleocapsid protein
Journal: White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Year: 2014

Crimean Congo haemorrhagic fever virus (CCHFV) is a tick borne nairovirus responsible for a highly fatal human disease with increased recent incidence within the human population of southern Europe. Hazara virus (HAZV), another tick borne nairovirus of the same serogroup as CCHFV, is not pathogenic in humans, but infection with HAZV results in a similar disease progression in interferon receptor knockout mice to CCHFV. In order to investigate further similarities between HAZV and CCHFV, and to s