Synthesıs of Condensed 1,4-Dıhydropyrıdıne Derıvatıves and Evaluatıon of Theır Calcıum Channel Modulatıng and Antıoxıdant Actıvıtıes
Journal: Hacettepe University Institutional Repository (hacettepe.edu.tr)
Year: 2014

In this study, study, a pharmacophore model based on calcium channel blocker ligands was generated by LigandScout and nineteen 2-(methacryloyloxy)ethyl 4-aryl-2,6,6-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate derivatives were synthesized via multicomponent one pot Hantzsch&#13;\nreaction of 4,4-dimethylcyclohexane-1,3-dione, 2-(methacryloyloxy)ethyl&#13;\nacetoacetate, substituted benzaldehyde and ammonium acetate in methanol under&#13;\nmicrowave irradiation in a short time. Th