Hematopoietic Development of Human Pluripotent Stem Cells
Journal: Biochemistry
Year: 2023

Blood development proceeds through several waves of hematopoietic progenitors with unclear lineage relationships, which convolute the understanding of the process. Thinking of the hematopoietic precursors as the “blood germ layer” can integrate these waves into a unified hematopoietic lineage that originates in the yolk sac, the earliest site of blood development. Hematopoietic differentiation of pluripotent stem cells (PSCs) reflects to a certain extent the complexities of the yolk sac hematopo