Antioxidant Effects of Sitagliptin in a Rat Model of Intestinal Ischemia/Reperfusion Injury
Journal: Journal of Advanced Pharmacy Research
Year: 2021

Objectives: This study aimed to assess the possible antioxidant role of sitagliptin on intestinal ischemia/reperfusion (II/R)-mediated tissue injury. Methods: Forty-five male Sprague-Dawley rats were randomly assigned into three groups: Sham group (operation without clamping), II/R group (operation with clamping) and Sitagliptin pretreated group (300 mg/kg/day; orally by gavage) for 2 weeks before II/R insult. II/R was performed by clamping the superior mesenteric artery for 30 min, followed by