The Emericellipsins A–E from an Alkalophilic Fungus Emericellopsis alkalina Show Potent Activity against Multidrug-Resistant Pathogenic Fungi
Journal: Journal of Fungi
Year: 2021

Novel antimicrobial peptides with antifungal and cytotoxic activity were derived from the alkalophilic fungus <i>Emericellopsis alkalina</i> VKPM F1428. We previously reported that this strain produced emericellipsin A (EmiA), which has strong antifungal and cytotoxic properties. Further analyses of the metabolites obtained under a special alkaline medium resulted in the isolation of four new homologous (Emi B-E). In this work, we report the complete primary structure and detailed biological act