Chitooligosaccharides Downregulate TLR4/NF-κB/COX-2 Signaling Cascade in Dextran Sulfate Sodium-treated Mice: A Potential Mechanism for the Anti-colitis Effect
Journal: International Journal of Pharmacology
Year: 2016

Background and Objective: The anti-inflammatory properties of chitooligosaccharides (COS), a new class of marine-derived natural products and functional foods have been well established, but the underlying mechanisms remain unclear. The aim of the present study is to investigate the effect and potential mechanisms of COS on colonic inflammation in a mouse model of experimental colitis induced by 3.5% Dextran Sulfate Sodium (DSS). Materials and Methods: Animals were randomly divided into 6 groups