Frequency of polymorphism of the &lt;i&gt;C-589T IL4&lt;/i&gt; and &lt;i&gt;G-1082A IL10&lt;/i&gt; genes in children with new coronavirus infection
Journal: Russian Journal of Immunology
Year: 2024

Immune responses are involved in the initiation and development of COVID-19. Compared with mild COVID-19 cases, serum interleukins levels were significantly increased in severe and critical COVID-19 patients. Increases in IL-4 and IL-10 are associated with disease severity. The C-589T polymorphism of IL4 gene is associated with increased promoter activity of gene. Allelic variants GA and GG-1082 of IL10 gene have greater activity compared to the AA-1082 IL10. The purpose was to study the frequen