Exploring the inhibitory potential of the antiarrhythmic drug amiodarone against <i>Clostridioides difficile</i> toxins TcdA and TcdB
Journal: Gut Microbes
Year: 2023

The intestinal pathogen <i>Clostridioides difficile</i> is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in humans. The symptoms of <i>C. difficile</i>-associated diseases (CDADs) are directly associated with the pathogen's toxins TcdA and TcdB, which enter host cells and inactivate Rho and/or Ras GTPases by glucosylation. Membrane cholesterol is crucial during the intoxication process of TcdA and TcdB, and likely involved during pore formation of both toxins i