Development of an infectious clone system to study the life cycle of Hazara virus
Journal: White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Year: 2020

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is a negative sense single stranded RNA virus, capable of causing fatal hemorrhagic fever in humans. Currently, an infectious clone system exists for CCHFV, however, owing to the high containment level required for experimentation with this virus, its potential is limited. Here, a highly efficient infectious clone system was developed for recovery of Hazara virus (HAZV), the first such orthonairovirus system able to be used in biosafety lev