A NEW MUTATION IN THE PALB2 GENE ASSOCIATED WITH HEREDITARY BREAST CANCER IN A YOUNG PATIENT BELONGING TO THE YAKUT ETHNIC GROUP
Journal: Cardiometry
Year: 2022

Breast cancer is the most common cancer worldwide. The oncosuppressor gene PALB2, along with such genes as BRCA1 and BRCA2, is involved in the repair of damaged DNA. The incidence of germline mutations in the PALB2 gene in breast cancer and in familial cases of pancreatic cancer is approximately 1–2% and 3–4%, respectively. A clinical case of a 39-year-old woman belonging to the Yakut ethnic group, diagnosed with breast cancer and with a family history of pancreatic cancer, is presented hereby.