Naturally Inspired Privileged Structures in Drug Discovery: Multifunctional Compounds for Alzheimer's Disease Treatment
Journal: AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna)
Year: 2016

Polypharmacology-based strategies are gaining ever-increasing attention as useful approaches to develop disease-modifying drug candidates for effective Alzheimer’s disease (AD) treatment. In this scenario, multitarget-directed ligands could increase efficiency by simultaneous modulation of several targets involved in AD pathogenesis. In drug discovery, natural products (NPs) represent an excellent source of evolutionary-chosen “privileged structures”.&#13;\nIn this thesis, the polyphenol curcumi