Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer’s disease model
Journal: Biology of Sex Differences
Year: 2025

We show for the first-time specific sex-dependent synaptic-plasticity proteome changes in dorsal/ventral hippocampi that modulate GSK-3β activity. These findings provide new insight into the early amyloidosis pathogenesis in AD and offer valuable, unique proteomic phenotypes as potential biomarkers and targets for early diagnosis and therapy in both sexes.