TLR-4 GENE POLYMORPHISM (ASP299GLY) IN ADULT PATIENTS WITH ATOPIC AND NON-ATOPIC BRONCHIAL ASTHMA IN THE CRIMEA POPULATION
Journal: PULMONOLOGIYA
Year: 2014

The aim of the study was to investigate TLR-4 gene polymorphism in adult patients with atopic and non-atopic bronchial asthma in the Crimea population. Methods. TLR-4 gene polymorphism (Asp299Gly) was studied in 275 patients with atopic asthma and 56 patients with non-atopic asthma; a control group included 285 healthy residents of Crimea. The allele-specific polymerase chain reaction with electrophoretic detection of polymorphism was used. Results. In the control group, genotype frequency distr