Question: As shown in figure, the dephosphorylated pRB protein is active in G1 phase. pRB binds to the transcription factor E2F and prevents E2F mediated G1->S transition. The Cyclin D-Cdk4 complex produced during G1, phosphorylates and thereby inactivates pRB. This allows the cell to enter S phase. The p16 protein inhibits the Cyclin D-Cdk4 complex. In which process are the proteins encoded by the target genes of E2F most likely to function?  A) DNA replication  B) RNA stabilization  C) Splicing  D) Transcription. Please choose an answer from [A, B, C, D].
Answer: A