Synapse - wikipedia Synapse This article is about synapses of the nervous system. For other uses, see Synapse ( disambiguation ). Structure of a typical chemical synapse Postsynaptic density Voltage - gated Ca channel Synaptic vesicle Neurotransmitter transporter Receptor Neurotransmitter Axon terminal Synaptic cleft Dendrite In the nervous system, a synapse is a structure that permits a neuron ( or nerve cell ) to pass an electrical or chemical signal to another neuron or to the target efferent cell. Santiago Ramón y Cajal proposed that neurons are not continuous throughout the body, yet still communicate with each other, an idea known as the neuron doctrine. The word `` synapse '' -- from the Greek synapsis ( συνάψις ), meaning `` conjunction '', in turn from συνάπτεὶν ( συν ( `` together '' ) and ἅπτειν ( `` to fasten '' ) ) -- was introduced in 1897 by the English neurophysiologist Charles Sherrington in Michael Foster 's Textbook of Physiology. Sherrington struggled to find a good term that emphasized a union between two separate elements, and the actual term `` synapse '' was suggested by the English classical scholar Arthur Woollgar Verrall, a friend of Michael Foster. Some authors generalize the concept of the synapse to include the communication from a neuron to any other cell type, such as to a motor cell, although such non-neuronal contacts may be referred to as junctions ( a historically older term ). Synapses are essential to neuronal function : neurons are cells that are specialized to pass signals to individual target cells, and synapses are the means by which they do so. At a synapse, the plasma membrane of the signal - passing neuron ( the presynaptic neuron ) comes into close apposition with the membrane of the target ( postsynaptic ) cell. Both the presynaptic and postsynaptic sites contain extensive arrays of a molecular machinery that link the two membranes together and carry out the signaling process. In many synapses, the presynaptic part is located on an axon and the postsynaptic part is located on a dendrite or soma. Astrocytes also exchange information with the synaptic neurons, responding to synaptic activity and, in turn, regulating neurotransmission. Synapses ( at least chemical synapses ) are stabilized in position by synaptic adhesion molecules ( SAMs ) projecting from both the pre - and post-synaptic neuron and sticking together where they overlap ; SAMs may also assist in the generation and functioning of synapses. Contents 1 Chemical or electrical 2 Types of interfaces 3 Role in memory 4 Study models 5 Synaptic polarization 6 Additional images 7 See also 8 References Chemical or electrical An example of chemical synapse by the release of neurotransmitters like acetylcholine or glutamic acid. There are two fundamentally different types of synapses : In a chemical synapse, electrical activity in the presynaptic neuron is converted ( via the activation of voltage - gated calcium channels ) into the release of a chemical called a neurotransmitter that binds to receptors located in the plasma membrane of the postsynaptic cell. The neurotransmitter may initiate an electrical response or a secondary messenger pathway that may either excite or inhibit the postsynaptic neuron. Chemical synapses can be classified according to the neurotransmitter released : glutamatergic ( often excitatory ), GABAergic ( often inhibitory ), cholinergic ( e.g. vertebrate neuromuscular junction ), and adrenergic ( releasing norepinephrine ). Because of the complexity of receptor signal transduction, chemical synapses can have complex effects on the postsynaptic cell. In an electrical synapse, the presynaptic and postsynaptic cell membranes are connected by special channels called gap junctions or synaptic cleft that are capable of passing an electric current, causing voltage changes in the presynaptic cell to induce voltage changes in the postsynaptic cell. The main advantage of an electrical synapse is the rapid transfer of signals from one cell to the next. Synaptic communication is distinct from an ephaptic coupling, in which communication between neurons occurs via indirect electric fields. An autapse is a chemical or electrical synapse that forms when the axon of one neuron synapses onto dendrites of the same neuron. Types of interfaces Synapses can be classified by the type of cellular structures serving as the pre - and post-synaptic components. The vast majority of synapses in the mammalian nervous system are classical axo - dendritic synapses ( axon synapsing upon a dendrite ), however, a variety of other arrangements exist. These include but are not limited to axo - axonic, dendro - dendritic, axo - secretory, somato - dendritic, dendro - somatic, and somato - somatic synapses. The axon can synapse onto a dendrite, onto a cell body, or onto another axon or axon terminal, as well as into the bloodstream or diffusely into the adjacent nervous tissue. Different types of synapses Role in memory Main article : Hebbian theory It is widely accepted that the synapse plays a role in the formation of memory. As neurotransmitters activate receptors across the synaptic cleft, the connection between the two neurons is strengthened when both neurons are active at the same time, as a result of the receptor 's signaling mechanisms. The strength of two connected neural pathways is thought to result in the storage of information, resulting in memory. This process of synaptic strengthening is known as long - term potentiation. By altering the release of neurotransmitters, the plasticity of synapses can be controlled in the presynaptic cell. The postsynaptic cell can be regulated by altering the function and number of its receptors. Changes in postsynaptic signaling are most commonly associated with a N - methyl - d - aspartic acid receptor ( NMDAR ) - dependent long - term potentiation ( LTP ) and long - term depression ( LTD ) due to the influx of calcium into the post-synaptic cell, which are the most analyzed forms of plasticity at excitatory synapses. Study models For technical reasons, synaptic structure and function have been historically studied at unusually large model synapses, for example : Squid giant synapse Neuromuscular junction ( NMJ ), a cholinergic synapse in vertebrates, glutamatergic in insects Ciliary calyx in the ciliary ganglion of chicks Calyx of Held in the brainstem Ribbon synapse in the retina Schaffer collateral synapse in the hippocampus Synaptic polarization The function of neurons depends upon cell polarity. The distinctive structure of nerve cells allows action potentials to travel directionally ( from dendrites to cell body down the axon ), and for these signals to then be received and carried on by post-synaptic neurons or received by effector cells. Nerve cells have long been used as models for cellular polarization, and of particular interest are the mechanisms underlying the polarized localization of synaptic molecules. PIP2 signaling regulated by IMPase plays an integral role in synaptic polarity. Phosphoinositides ( PIP, PIP2, and PIP3 ) are molecules that have been shown to affect neuronal polarity. A gene ( ttx - 7 ) was identified in Caenorhabditis elegans that encodes myo - inositol monophosphatase ( IMPase ), an enzyme that produces inositol by dephosphorylating inositol phosphate. Organisms with mutant ttx - 7 genes demonstrated behavioral and localization defects, which were rescued by expression of IMPase. This led to the conclusion that IMPase is required for the correct localization of synaptic protein components. The egl - 8 gene encodes a homolog of phospholipase C β ( PLCβ ), an enzyme that cleaves PIP2. When ttx - 7 mutants also had a mutant egl - 8 gene, the defects caused by the faulty ttx - 7 gene were largely reversed. These results suggest that PIP2 signaling establishes polarized localization of synaptic components in living neurons. Additional images A typical central nervous system synapse The synapse and synaptic vesicle cycle Major elements in chemical synaptic transmission See also Neuroscience portal Active zone Autapse Exocytosis Immunological synapse Neurotransmitter vesicle Postsynaptic density Synaptopathy References ^ Jump up to : Foster, M. ; Sherrington, C.S. ( 1897 ). Textbook of Physiology, volume 3 ( 7th ed. ). London : Macmillan. p. 929. Jump up ^ Elias, Lorin J. ; Saucier, Deborah M. ( 2006 ). Neuropsychology : Clinical and Experimental Foundations. Boston : Pearson / Allyn & Bacon. ISBN 978 - 0 - 20534361 - 4. LCCN 2005051341. OCLC 61131869. Jump up ^ `` synapse ''. Online Etymology Dictionary. Retrieved 2013 - 10 - 01. Jump up ^ Tansey, E.M. ( 1997 ). `` Not committing barbarisms : Sherrington and the synapse, 1897 ''. Brain Research Bulletin. Amsterdam : Elsevier. 44 ( 3 ) : 211 -- 212. doi : 10.1016 / S0361 - 9230 ( 97 ) 00312 - 2. PMID 9323432. The word synapse first appeared in 1897, in the seventh edition of Michael Foster 's Textbook of Physiology. Jump up ^ Schacter, Daniel L. ; Gilbert, Daniel T. ; Wegner, Daniel M. ( 2011 ). Psychology ( 2nd ed. ). New York : Worth Publishers. p. 80. ISBN 978 - 1 - 4292 - 3719 - 2. LCCN 2010940234. OCLC 696604625. Jump up ^ Perea, G. ; Navarrete, M. ; Araque, A. ( August 2009 ). `` Tripartite synapses : astrocytes process and control synaptic information ''. Trends in Neurosciences. Cambridge, MA : Cell Press. 32 ( 8 ) : 421 -- 431. doi : 10.1016 / j. tins. 2009.05. 001. PMID 19615761. Jump up ^ Missler, M ; Südhof, TC ; Biederer, T ( 2012 ). `` Synaptic cell adhesion ''. Cold Spring Harb Perspect Biol. 4 : a005694. doi : 10.1101 / cshperspect. a005694. PMC 3312681. PMID 22278667. Jump up ^ Silverthorn, Dee Unglaub ( 2007 ). Human Physiology : An Integrated Approach. Illustration coordinator William C. Ober ; illustrations by Claire W. Garrison ; clinical consultant Andrew C. Silverthorn ; contributions by Bruce R. Johnson ( 4th ed. ). San Francisco : Pearson / Benjamin Cummings. p. 271. ISBN 978 - 0 - 8053 - 6851 - 2. LCCN 2005056517. OCLC 62742632. Jump up ^ Lynch, M.A. ( January 1, 2004 ). `` Long - Term Potentiation and Memory ''. Physiological Reviews. 84 ( 1 ) : 87 -- 136. doi : 10.1152 / physrev. 00014.2003. PMID 14715912. Jump up ^ Krugers, Harm J. ; Zhou, Ming ; Joëls, Marian ; Kindt, Merel ( October 11, 2011 ). `` Regulation of Excitatory Synapses and Fearful Memories by Stress Hormones ''. Frontiers in Behavioral Neuroscience. Switzerland : Frontiers Media SA. 5 : 62. doi : 10.3389 / fnbeh. 2011.00062. PMC 3190121. PMID 22013419. Jump up ^ Stanley, EF ( 1992 ). `` The calyx - type synapse of the chick ciliary ganglion as a model of fast cholinergic transmission ''. Canadian Journal of Physiology and Pharmacology. 70 Suppl : S73 -- 7. doi : 10.1139 / y92 - 246. PMID 1338300. Jump up ^ Arimura, Nariko ; Kaibuchi, Kozo ( December 22, 2005 ). `` Key regulators in neuronal polarity ''. Neuron. Cambridge, MA : Cell Press. 48 ( 6 ) : 881 -- 884. doi : 10.1016 / j. neuron. 2005.11. 007. PMID 16364893. ^ Jump up to : Kimata, Tsubasa ; Tanizawa, Yoshinori ; Can, Yoko ; et al. ( June 1, 2012 ). `` Synaptic Polarity Depends on Phosphatidylinositol Signaling Regulated by myo - Inositol Monophosphatase in Caenorhabditis elegans ''. Genetics. Bethesda, MD : Genetics Society of America. 191 ( 2 ) : 509 -- 521. doi : 10.1534 / genetics. 111.137844. PMC 3374314. PMID 22446320. Jump up ^ Tanizawa, Yoshinori ; Kuhara, Atsushi ; Inada, Hitoshi ; et al. ( December 1, 2006 ). `` Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans ''. Genes & Development. Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press. 20 ( 23 ) : 3296 -- 3310. doi : 10.1101 / gad. 1497806. PMC 1686606. PMID 17158747. Nervous tissue CNS Tissue Types Grey matter White matter Projection fibers Association fiber Commissural fiber Lemniscus Funiculus Fasciculus Nerve tract Decussation Commissure Neuropil Meninges Cell Types Neuronal Pyramidal Purkinje Granule Glial insulating : Myelination : Oligodendrocyte other Astrocyte Radial glial cell Ependymal cells Tanycyte Microglia PNS General Dorsal Root Ganglion Ramus Ventral Root Ramus Ramus communicans Gray White Autonomic ganglion ( Preganglionic nerve fibers Postganglionic nerve fibers ) Connective tissues Epineurium Perineurium Endoneurium Nerve fascicle Neuroglia Myelination : Schwann cell Neurilemma Myelin incisure Node of Ranvier Internodal segment Satellite glial cell Neurons / nerve fibers Parts Soma Axon hillock Axon Telodendron Axon terminals Axoplasm Axolemma Neurofibril / neurofilament Dendrite Nissl body Dendritic spine Apical dendrite / Basal dendrite Types Bipolar Unipolar Pseudounipolar Multipolar Interneuron Renshaw Afferent nerve fiber / Sensory neuron GSA GVA SSA SVA fibers Ia or Aα Ib or Golgi or Aα II or Aβ and Aγ III or Aδ or fast pain IV or C or slow pain Efferent nerve fiber / Motor neuron GSE GVE SVE Upper motor neuron Lower motor neuron α motorneuron β motorneuron γ motorneuron Termination Synapse Electrical synapse / Gap junction Chemical synapse Synaptic vesicle Active zone Postsynaptic density Autapse Ribbon synapse Neuromuscular junction Sensory receptors Meissner 's corpuscle Merkel nerve ending Pacinian corpuscle Ruffini ending Muscle spindle Free nerve ending Nociceptor Olfactory receptor neuron Photoreceptor cell Hair cell Taste bud Retrieved from `` https://en.wikipedia.org/w/index.php?title=Synapse&oldid=837129123 '' Categories : Cell signaling Signal transduction Neural synapse Hidden categories : Articles containing Ancient Greek - language text Talk Contents About Wikipedia Afrikaans Asturianu Беларуская Български Bosanski Català Čeština Dansk Deutsch Eesti Ελληνικά Español Esperanto Euskara فارسی Français Gaeilge Galego 한국어 Հայերեն हिन्दी Hrvatski Ido Bahasa Indonesia Íslenska Italiano עברית ქართული Қазақша Kreyòl ayisyen Кыргызча Lietuvių Magyar Македонски Nederlands 日本 語 Norsk Occitan Oʻzbekcha / ўзбекча Polski Português Română Русский Seeltersk Slovenčina کوردی Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska Tagalog தமிழ் ไทย Türkçe Українська اردو 中文 49 more Edit links This page was last edited on 18 April 2018, at 22 : 13. 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Question: who discovered that neural communication between cells occurs through chemicals
Answer: Charles Sherrington