Sessile serrated adenoma - wikipedia Sessile serrated adenoma Sessile serrated adenoma Micrograph of a sessile serrated adenoma. H&E stain. Classification and external resources ( edit on Wikidata ) In gastroenterology, a sessile serrated adenoma ( abbreviated SSA ), also known as sessile serrated polyp ( abbreviated SSP ), is a premalignant flat ( or sessile ) lesion of the colon, predominantly seen in the cecum and ascending colon. SSAs are thought to lead to colorectal cancer through the ( alternate ) serrated pathway. This differs from most colorectal cancer, which arises from mutations starting with inactivation of the APC gene. Multiple SSAs may be part of the serrated polyposis syndrome. Contents 1 Symptoms 2 Diagnosis 3 Serrated polyposis syndrome 4 Treatment 5 Additional images 6 See also 7 References 8 External links Symptoms SSAs, generally, are asymptomatic. They are typically identified on a colonoscopy and excised for a definitive diagnosis and treatment. Diagnosis SSAs are diagnosed by their microscopic appearance ; histomorphologically, they are characterized by ( 1 ) basal dilation of the crypts, ( 2 ) basal crypt serration, ( 3 ) crypts that run horizontal to the basement membrane ( horizontal crypts ), and ( 4 ) crypt branching. The most common of these features is basal dilation of the crypts. Unlike traditional colonic adenomas ( e.g. tubular adenoma, villous adenoma ), they do not ( typically ) have nuclear changes ( nuclear hyperchromatism, nuclear crowding, elliptical / cigar - shaped nuclei ). Serrated polyposis syndrome The serrated polyposis syndrome ( SPS ) is a relatively rare condition characterized by multiple and / or large serrated polyps of the colon. Diagnosis of this disease is made by the fulfillment of any of the World Health Organization 's ( WHO ) clinical criteria. Treatment Complete removal of a SSA is considered curative. Several SSAs confer a higher risk of subsequently finding colorectal cancer and warrant more frequent surveillance. The surveillance guidelines are the same as for other colonic adenomas. The surveillance interval is dependent on ( 1 ) the number of adenomas, ( 2 ) the size of the adenomas, and ( 3 ) the presence of high - grade microscopic features. Additional images Low magnification micrograph of a SSA. Intermediate magnification micrograph of a SSA. High magnification micrograph of a SSA showing crypt branching. See also Polyp table Colonic polyps Colorectal polyps Colorectal carcinoma Microsatellite instability References Jump up ^ Rüschoff J, Aust D, Hartmann A ( 2007 ). `` ( Colorectal serrated adenoma : diagnostic criteria and clinical implications ) ''. Verh Dtsch Ges Pathol ( in German ). 91 : 119 -- 25. PMID 18314605. Jump up ^ Mäkinen MJ ( January 2007 ). `` Colorectal serrated adenocarcinoma ''. Histopathology. 50 ( 1 ) : 131 -- 50. doi : 10.1111 / j. 1365 - 2559.2006. 02548. x. PMID 17204027. Jump up ^ Rosty, C. ; Parry, S. ; Young, JP. ( 2011 ). `` Serrated polyposis : an enigmatic model of colorectal cancer predisposition ''. Patholog Res Int. 2011 : 157073. doi : 10.4061 / 2011 / 157073. PMC 3109311. PMID 21660283. Jump up ^ World J Gastroenterol 2012 May 28 ; 18 ( 20 ) : 2452 - 2461 Jump up ^ Levine JS, Ahnen DJ ( December 2006 ). `` Clinical practice. Adenomatous polyps of the colon '' ( PDF ). N. Engl. J. Med. 355 ( 24 ) : 2551 -- 7. doi : 10.1056 / NEJMcp063038. PMID 17167138. External links Intestinal adenomas - halflytely.com. Pathology of Serrated Colon Adenomas - Medscape Retrieved from `` https://en.wikipedia.org/w/index.php?title=Sessile_serrated_adenoma&oldid=722266847 '' Categories : Digestive system neoplasia Histopathology Hidden categories : CS1 German - language sources ( de ) Infobox medical condition Talk Contents About Wikipedia Français Edit links This page was last edited on 27 May 2016, at 00 : 00. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: what is a serrated adenoma of the colon
Answer: a premalignant flat (or sessile) lesion of the colon; a premalignant flat (or sessile) lesion of the colon, predominantly seen in the cecum and ascending colon