Epithelium - wikipedia Epithelium This article is about epithelium in animal anatomy. For the fungal structure of the same name, see Pileipellis. Epithelium Types of epithelium Pronunciation epi - + thele + - ium Identifiers MeSH D004848 TH H2. 00.02. 0.00002 FMA 9639 Anatomical terms of microanatomy ( edit on Wikidata ) This article is one of a series on Epithelia Squamous epithelial cell Simple Stratified Columnar epithelial cell Simple Stratified Pseudostratified Cuboidal epithelial cell Simple Stratified Specialised epithelia Olfactory Respiratory Intestinal Transitional Vaginal Germinal female male Other Table of epithelia of human organs Epithelium ( / ˌɛpɪˈθiːliəm / ) is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. Epithelial tissues line the outer surfaces of organs and blood vessels throughout the body, as well as the inner surfaces of cavities in many internal organs. An example is the epidermis, the outermost layer of the skin. There are three principal shapes of epithelial cell : squamous, columnar, and cuboidal. These can be arranged in a single layer of cells as simple epithelium, either squamous, columnar, cuboidal, pseudo-stratified columnar or in layers of two or more cells deep as stratified ( layered ), either squamous, columnar or cuboidal. All glands are made up of epithelial cells. Functions of epithelial cells include secretion, selective absorption, protection, transcellular transport, and sensing. Epithelial layers contain no blood vessels, so they must receive nourishment via diffusion of substances from the underlying connective tissue, through the basement membrane. Cell junctions are well - employed in epithelial tissues. Contents 1 Classification 1.1 Simple epithelium 1.2 Stratified epithelium 2 Cell types 3 Structure 3.1 Location 3.2 Basement membrane 3.3 Cell junctions 3.4 Development 4 Functions 4.1 Glandular tissue 4.2 Sensing the extracellular environment 5 Clinical significance 6 Etymology and pronunciation 7 Additional images 8 See also 9 References 9.1 Bibliography 10 Further reading 11 External links Classification Summary showing different epithelial cells / tissues and their characteristics. In general, epithelial tissues are classified by the number of their layers and by the shape and function of the cells. The three principal shapes associated with epithelial cells are -- squamous, cuboidal and columnar. Squamous epithelium has cells that are wider than their height ( flat and scale - like ). Cuboidal epithelium has cells whose height and width are approximately the same ( cube shaped ). Columnar epithelium has cells taller than they are wide ( column - shaped ). By layer, epithelium is classed as either simple epithelium, only one cell thick ( unilayered ) or stratified epithelium as stratified squamous epithelium, stratified cuboidal epithelium, and stratified columnar epithelium that are two or more cells thick ( multi-layered ), and both types of layering can be made up of any of the cell shapes. However, when taller simple columnar epithelial cells are viewed in cross section showing several nuclei appearing at different heights, they can be confused with stratified epithelia. This kind of epithelium is therefore described as pseudostratified columnar epithelium. Transitional epithelium has cells that can change from squamous to cuboidal, depending on the amount of tension on the epithelium. Simple epithelium Simple epithelium is a single layer of cells with every cell in direct contact with the basement membrane that separates it from the underlying connective tissue. In general, it is found where absorption and filtration occur. The thinness of the epithelial barrier facilitates these processes. In general, simple epithelial tissues are classified by the shape of their cells. The four major classes of simple epithelium are : ( 1 ) simple squamous ; ( 2 ) simple cuboidal ; ( 3 ) simple columnar ; ( 4 ) pseudostratified. ( 1 ) simple squamous ; which is found lining areas where passive diffusion of gases occur. e.g. skin, walls of capillaries, linings of the pericardial, pleural, and peritoneal cavities, as well as the linings of the alveoli of the lungs. ( 2 ) simple cuboidal : these cells may have secretory, absorptive, or excretory functions. examples include small collecting ducts of kidney, pancreas, and salivary gland. ( 3 ) simple columnar ; cells can be secretory, absorptive, or excretory ; Simple columnar epithelium can be ciliated or non-ciliated ; ciliated columnar is found in the female reproductive tract and uterus. Non-ciliated epithelium can also possess microvilli. ( 4 ) pseudostratified columnar epithelium ; can be ciliated or non-ciliated. The ciliated type is also called respiratory epithelium as it is almost exclusively confined to the larger respiratory airways of the nasal cavity, trachea and bronchi. Stratified epithelium Stratified epithelium differs from simple epithelium in that it is multilayered. It is therefore found where body linings have to withstand mechanical or chemical insult such that layers can be abraded and lost without exposing subepithelial layers. Cells flatten as the layers become more apical, though in their most basal layers the cells can be squamous, cuboidal or columnar. Stratified epithelia ( of columnar, cuboidal or squamous type ) can have the following specializations : Specialization Description Keratinized In this particular case, the most apical layers ( exterior ) of cells are dead and lose their nucleus and cytoplasm, instead contain a tough, resistant protein called keratin. This specialization makes the epithelium waterproof, so is found in the mammalian skin. The lining of the esophagus is an example of a non-keratinized or `` moist '' stratified epithelium. Parakeratinized In this case, the most apical layers of cells are filled with keratin, but they still retain their nuclei. These nuclei are pyknotic, meaning that they are highly condensed. Parakeratinized epithelium is sometimes found in the oral mucosa and in the upper regions of the esophagus. Transitional Transitional epithelia are found in tissues that stretch and it can appear to be stratified cuboidal when the tissue is relaxed, or stratified squamous when the organ is distended and the tissue stretches. It is sometimes called urothelium since it is almost exclusively found in the bladder, ureters and urethra. Cell types The basic cell types are squamous, cuboidal, and columnar classed by their shape. Type Description Squamous Squamous cells have the appearance of thin, flat plates that can look polygonal when viewed from above. Their name comes from squāma, Latin for scale -- as on fish or snake skin. The cells fit closely together in tissues ; providing a smooth, low - friction surface over which fluids can move easily. The shape of the nucleus usually corresponds to the cell form and helps to identify the type of epithelium. Squamous cells tend to have horizontally flattened, nearly oval shaped nuclei because of the thin flattened form of the cell. Squamous epithelium is found lining surfaces such as the skin, and alveoli in the lung, enabling simple passive diffusion as also found in the alveolar epithelium in the lungs. Specialized squamous epithelium also forms the lining of cavities such as in blood vessels, as endothelium and in the pericardium, as mesothelium and in other body cavities. Cuboidal Cuboidal epithelial cells have a cube - like shape and appear square in cross-section. The cell nucleus is large, spherical and is in the centre of the cell. Cuboidal epithelium is commonly found in secretive tissue such as the exocrine glands, or in absorptive tissue such as the pancreas, the lining of the kidney tubules as well as in the ducts of the glands. The germinal epithelium that covers the female ovary, and the germinal epithelium that lines the walls of the seminferous tubules in the testes are also of the cuboidal type. Cuboidal cells provide protection and may be active in pumping material in or out of the lumen, or passive depending on their location and specialisation. Simple cuboidal epithelium commonly differentiates to form the secretory and duct portions of glands. Stratified cuboidal epithelium protects areas such as the ducts of sweat glands, mammary glands, and salivary glands. Columnar Columnar epithelial cells are elongated and column - shaped and have a height of at least four times their width. Their nuclei are elongated and are usually located near the base of the cells. Columnar epithelium forms the lining of the stomach and intestines. The cells here may possess microvilli for maximising the surface area for absorption and these microvilli may form a brush border. Other cells may be ciliated to move mucus in the function of mucociliary clearance. Other ciliated cells are found in the fallopian tubes, the uterus and central canal of the spinal cord. Some columnar cells are specialized for sensory reception such as in the nose, ears and the taste buds. Hair cells in the inner ears have stereocilia which are similar to microvilli. Goblet cells are modified columnar cells and are found between the columnar epithelial cells of the duodenum. They secrete mucus, which acts as a lubricant. Single - layered non-ciliated columnar epithelium tends to indicate an absorptive function. Stratified columnar epithelium is rare but is found in lobar ducts in the salivary glands, the eye, pharynx and sex organs. This consists of a layer of cells resting on at least one other layer of epithelial cells which can be squamous, cuboidal, or columnar. Pseudostratified These are simple columnar epithelial cells whose nuclei appear at different heights, giving the misleading ( hence `` pseudo '' ) impression that the epithelium is stratified when the cells are viewed in cross section. Ciliated pseudostratified epithelial cells have cilia. Cilia are capable of energy dependent pulsatile beating in a certain direction through interaction of cytoskeletal microtubules and connecting structural proteins and enzymes. In the respiratory tract the wafting effect produced causes mucus secreted locally by the goblet cells ( to lubricate and to trap pathogens and particles ) to flow in that direction ( typically out of the body ). Ciliated epithelium is found in the airways ( nose, bronchi ), but is also found in the uterus and Fallopian tubes, where the cilia propel the ovum to the uterus. Structure Cells of epithelial tissue are tightly packed and form a continuous sheet. They have almost no intercellular spaces. All epithelia is usually separated from underlying tissues by an extracellular fibrous basement membrane. The lining of the mouth, lung alveoli and kidney tubules all are made of epithelial tissue. The lining of the blood and lymphatic vessels are of a specialised form of epithelium called endothelium. Location See also : Table of epithelia of human organs Epithelium lines both the outside ( skin ) and the inside cavities and lumina of bodies. The outermost layer of human skin is composed of dead stratified squamous, keratinized epithelial cells. Tissues that line the inside of the mouth, the oesophagus, the vagina, and part of the rectum are composed of nonkeratinized stratified squamous epithelium. Other surfaces that separate body cavities from the outside environment are lined by simple squamous, columnar, or pseudostratified epithelial cells. Other epithelial cells line the insides of the lungs, the gastrointestinal tract, the reproductive and urinary tracts, and make up the exocrine and endocrine glands. The outer surface of the cornea is covered with fast - growing, easily regenerated epithelial cells. A specialised form of epithelium -- endothelium forms the inner lining of blood vessels and the heart, and is known as vascular endothelium, and lining lymphatic vessels as lymphatic endothelium. Another type, mesothelium, forms the walls of the pericardium, pleurae, and peritoneum. In arthropods, the integument, or external `` skin '', consists of a single layer of epithelial ectoderm from which arises the cuticle, an outer covering of chitin the rigidity of which varies as per its chemical composition. Basement membrane Epithelial tissue rests on a basement membrane, which acts as a scaffolding on which epithelium can grow and regenerate after injuries. Epithelial tissue has a nerve supply, but no blood supply and must be nourished by substances diffusing from the blood vessels in the underlying tissue. The basement membrane acts as a selectively permeable membrane that determines which substances will be able to enter the epithelium. Cell junctions Cell junctions are especially abundant in epithelial tissues. They consist of protein complexes and provide contact between neighbouring cells, between a cell and the extracellular matrix, or they build up the paracellular barrier of epithelia and control the paracellular transport. Cell junctions are the contact points between plasma membrane and tissue cells. There are mainly 5 different types of cell junctions : tight junctions, adherens junctions, desmosomes, hemidesmosomes, and gap junctions. Tight junctions are a pair of trans - membrane protein fused on outer plasma membrane. Adherens junctions are a plaque ( protein layer on the inside plasma membrane ) which attaches both cells ' microfilaments. Desmosomes attach to the microfilaments of cytoskeleton made up of keratin protein. Hemidesmosomes resemble desmosomes on a section. They are made up of the integrin ( a transmembrane protein ) instead of cadherin. They attach the epithelial cell to the basement membrane. Gap junctions connect the cytoplasm of two cells and are made up of proteins called connexins ( six of which come together to make a connexion ). Development Epithelial tissues are derived from all of the embryological germ layers : from ectoderm ( e.g., the epidermis ) ; from endoderm ( e.g., the lining of the gastrointestinal tract ) ; from mesoderm ( e.g., the inner linings of body cavities ). However, it is important to note that pathologists do not consider endothelium and mesothelium ( both derived from mesoderm ) to be true epithelium. This is because such tissues present very different pathology. For that reason, pathologists label cancers in endothelium and mesothelium sarcomas, whereas true epithelial cancers are called carcinomas. Also, the filaments that support these mesoderm - derived tissues are very distinct. Outside of the field of pathology, it is, in general, accepted that the epithelium arises from all three germ layers. Functions Forms of secretion in glandular tissue Different characteristics of glands of the body Epithelial tissues have as their primary functions : to protect the tissues that lie beneath from radiation, desiccation, toxins, invasion by pathogens, and physical trauma the regulation and exchange of chemicals between the underlying tissues and a body cavity the secretion of hormones into the circulatory system, as well as the secretion of sweat, mucus, enzymes, and other products that are delivered by ducts to provide sensation Glandular tissue Glandular tissue is the type of epithelium that forms the glands from the infolding of epithelium and subsequent growth in the underlying connective tissue. There are two major classifications of glands : endocrine glands and exocrine glands : Endocrine glands secrete their product into the extracellular space where it is rapidly taken up by the circulatory system. Exocrine glands secrete their products into a duct that then delivers the product to the lumen of an organ or onto the free surface of the epithelium. Sensing the extracellular environment `` Some epithelial cells are ciliated, especially in respiratory epithelium, and they commonly exist as a sheet of polarised cells forming a tube or tubule with cilia projecting into the lumen. '' Primary cilia on epithelial cells provide chemosensation, thermoception, and mechanosensation of the extracellular environment by playing `` a sensory role mediating specific signalling cues, including soluble factors in the external cell environment, a secretory role in which a soluble protein is released to have an effect downstream of the fluid flow, and mediation of fluid flow if the cilia are motile. '' Clinical significance Epithelial cell infected with Chlamydia pneumoniae The slide shows at ( 1 ) an epithelial cell infected by Chlamydia pneumonia ; their inclusion bodies shown at ( 3 ) ; an uninfected cell shown at ( 2 ) and ( 4 ) showing the difference between an infected cell nucleus and an uninfected cell nucleus. Epithelium grown in culture can be identified by examining its morphological characteristics. Epithelial cells tend to cluster together, and have a `` characteristic tight pavement - like appearance ''. But this is not always the case, such as when the cells are derived from a tumor. In these cases, it is often necessary to use certain biochemical markers to make a positive identification. The intermediate filament proteins in the cytokeratin group are almost exclusively found in epithelial cells, and so are often used for this purpose. Carcinomas develop in epithelial tissues. Sarcomas develop in connective tissue. When epithelial cells or tissues are damaged from cystic fibrosis, sweat glands are also damaged, causing a frosty coating of the skin. Etymology and pronunciation The word epithelium uses the Greek roots ἐπί ( epi ), `` on '' or `` upon '', and θηλή ( thēlē ), `` nipple ''. Epithelium is so called because the name was originally used to describe the translucent covering of small `` nipples '' of tissue on the lip. The word has both mass and count senses ; the plural form is epithelia. Additional images Squamous Epithelium 100x Human cheek cells ( Nonkeratinized stratified squamous epithelium ) 500x Histology of female urethra showing transitional epithelium Histology of sweat gland showing stratified cuboidal epithelium See also Blastula Dark cell Epithelial - mesenchymal transition Epithelial polarity Gastrulation Glycocalyx Neuroepithelial cell Skin cancer Sulcular epithelium Triploblasty References Jump up ^ https://dictionary.cambridge.org/dictionary/english/epithelium ^ Jump up to : Eurell, Jo Ann C. ; et al., eds. ( 2006 ). Dellmann 's textbook of veterinary histology. Wiley - Blackwell. p. 18. ISBN 978 - 0 - 7817 - 4148 - 4. ^ Jump up to : Freshney, 2002 : p. 3 ^ Jump up to : Marieb, Elaine M. ( 1995 ). Human Anatomy and Physiology ( 3rd ed. ). Benjamin / Cummings. pp. 103 -- 104. ISBN 0 - 8053 - 4281 - 8. Jump up ^ Platzer, Werner ( 2008 ). Color atlas of human anatomy : Locomotor system. Thieme. p. 8. ISBN 978 - 3 - 13 - 533306 - 9. Jump up ^ van Lommel, 2002 : p. 97 Jump up ^ van Lommel, 2002 : p. 94 Jump up ^ Melfi, Rudy C. ; Alley, Keith E., eds. ( 2000 ). Permar 's oral embryology and microscopic anatomy : a textbook for students in dental hygiene. Lippincott Williams & Wilkins. p. 9. ISBN 978 - 0 - 683 - 30644 - 6. Jump up ^ Pratt, Rebecca. `` Epithelial Cells ''. AnatomyOne. Amirsys, Inc. Archived from the original on 2012 - 12 - 19. Retrieved 2012 - 09 - 28. ^ Jump up to : Jenkins, Gail W. ; Tortora, Gerard J. ( 2013 ). Anatomy and Physiology from Science to Life ( 3rd ed. ). John Wiley & Sons. pp. 110 -- 115. ISBN 978 - 1 - 118 - 12920 - 3. Jump up ^ Ross, Michael H. ; Pawlina, Wojciech ( 2015 ). Histology : A Text and Atlas : With Correlated Cell and Molecular Biology ( 7th ed. ). Lippincott Williams & Wilkins. p. 528, 604. ISBN 978 - 1451187427. Jump up ^ Kühnel, Wolfgang ( 2003 ). Color atlas of cytology, histology, and microscopic anatomy. Thieme. p. 102. ISBN 978 - 3 - 13 - 562404 - 4. Jump up ^ Pratt, Rebecca. `` Simple Cuboidal Epithelium ''. AnatomyOne. Amirsys, Inc. Retrieved 2012 - 09 - 28. Jump up ^ Eroschenko, Victor P. ( 2008 ). `` Integumentary System ''. DiFiore 's Atlas of Histology with Functional Correlations. Lippincott Williams & Wilkins. pp. 212 -- 234. ISBN 9780781770576. Jump up ^ Marieb, Elaine ( 2011 ). Anatomy & Physiology. Boston : Benjamin Cummings. p. 133. ISBN 0321616405. Jump up ^ Kristensen, Niels P. ; Georges, Chauvin ( 1 December 2003 ). `` Integument ''. Lepidoptera, Moths and Butterflies : Morphology, Physiology, and Development : Teilband. Walter de Gruyter. p. 484. ISBN 978 - 3 - 11 - 016210 - 3. Retrieved 10 January 2013. Jump up ^ McConnell, Thomas H. ( 2006 ). The nature of disease : pathology for the health professions. Lippincott Williams & Wilkins. p. 55. ISBN 978 - 0 - 7817 - 5317 - 3. Jump up ^ Alberts, Bruce ( 2002 ). Molecular biology of the cell ( 4. ed. ). New York ( u.a. ) : Garland. p. 1067. ISBN 0 - 8153 - 4072 - 9. Jump up ^ van Lommel, 2002 : p. 91 Jump up ^ Alberts, Bruce ( 2002 ). Molecular biology of the cell ( 4 ed. ). New York ( u.a. ) : Garland. p. 1267. ISBN 0 - 8153 - 4072 - 9. Jump up ^ Adams, M. ; Smith, U.M. ; Logan, C.V. ; Johnson, C.A. ( 2008 ). `` Recent advances in the molecular pathology, cell biology and genetics of ciliopathies ''. Journal of Medical Genetics. 45 ( 5 ) : 257 -- 267. doi : 10.1136 / jmg. 2007.054999. PMID 18178628. Jump up ^ Freshney, 2002 : p. 9 Jump up ^ `` Types of cancer ''. Cancer Research UK. 28 October 2014. Retrieved 13 October 2016. Jump up ^ Blerkom, edited by Jonathan Van ; Gregory, Linda ( 2004 ). Essential IVF : basic research and clinical applications. Boston : Kluwer Academic Publishers. p. 3. ISBN 978 - 1 - 4020 - 7551 - 3. CS1 maint : Extra text : authors list ( link ) Bibliography Freshney, R.I. ( 2002 ). `` Introduction ''. In Freshney, R. Ian ; Freshney, Mary. Culture of epithelial cells. John Wiley & Sons. ISBN 978 - 0 - 471 - 40121 - 6. van Lommel, Alfons T.L. ( 2002 ). From cells to organs : a histology textbook and atlas. Springer. ISBN 978 - 1 - 4020 - 7257 - 4. Further reading Green H ( September 2008 ). `` The birth of therapy with cultured cells ''. BioEssays. 30 ( 9 ) : 897 -- 903. doi : 10.1002 / bies. 20797. PMID 18693268. Kefalides, Nicholas A. ; Borel, Jacques P., eds. ( 2005 ). Basement membranes : cell and molecular biology. Gulf Professional Publishing. ISBN 978 - 0 - 12 - 153356 - 4. Nagpal R ; Patel A ; Gibson MC ( March 2008 ). `` Epithelial topology ''. BioEssays. 30 ( 3 ) : 260 -- 6. doi : 10.1002 / bies. 20722. PMID 18293365. Yamaguchi Y ; Brenner M ; Hearing VJ ( September 2007 ). `` The regulation of skin pigmentation '' ( Review ). J. Biol. Chem. 282 ( 38 ) : 27557 -- 61. doi : 10.1074 / jbc. R700026200. PMID 17635904. External links Look up epithelium in Wiktionary, the free dictionary. Epithelium Photomicrographs 1 Histology at KUMC epithel - epith02 Simple squamous epithelium of the glomerulus ( kidney ) 2 Diagrams of simple squamous epithelium 3 Histology at KUMC epithel - epith12 Stratified squamous epithelium of the vagina 4 Histology at KUMC epithel - epith14 Stratified squamous epithelium of the skin ( thin skin ) 5 Histology at KUMC epithel - epith15 Stratified squamous epithelium of the skin ( thick skin ) 6 Stratified squamous epithelium of the esophagus Microanatomy Web Atlas Epithelial tissue Cells Squamous Cuboidal Columnar Types Simple squamous epithelium Endothelium Mesothelium Simple cuboidal epithelium Simple columnar epithelium Pseudostratified columnar epithelium Respiratory epithelium Stratified squamous epithelium Stratified cuboidal epithelium Stratified columnar epithelium Transitional epithelium Urothelium Glands Types Mechanism Merocrine Eccrine Apocrine Holocrine Sebaceous Meibomian Shape Tubular gland Alveolar gland Secretion Serous glands Mucous glands Components Myoepithelial cell Serous demilune Ducts : Interlobar Interlobular Intralobular Striated Intercalated Acinus / Lobe Biological tissues Animals Epithelial Connective Muscular Nervous Plants Dermal tissue : Epidermis Cuticle Pavement cell Guard cell Subsidiary cell Periderm Phellem Phelloderm Vascular tissue : Phloem Sieve tube Companion cell Phloem fiber Phloem parenchyma Xylem Tracheid Vessel element Xylem fiber Xylem parenchyma Ground tissue : Parenchyma Aerenchyma Chlorenchyma Mesophyll Pith Collenchyma Sclerenchyma Sclereid Fiber Meristematic tissue : Primary Protoderm Procambium Ground meristem Secondary Cork cambium Vascular cambium Mixed : Cortex Exodermis Endodermis Stele Histology Proteins of epithelium Lateral / cell - cell Cell adhesion molecules : Adherens junction Cadherin Desmosome Desmoglein Ion channels : Gap junction / Connexon Connexin Cytoskeleton : Desmosome Desmoplakin Plakoglobin Tonofibril other membrane proteins : Tight junction Claudin Occludin MARVELD2 Basal / cell - matrix Basal lamina Hemidesmosome / Tonofibril Focal adhesion Costamere Apical Cilia / Kinocilium Microvilli / Stereocilia ( STRC ) Retrieved from `` https://en.wikipedia.org/w/index.php?title=Epithelium&oldid=838235499 '' Categories : Epithelium Hidden categories : Pages with unresolved properties CS1 maint : Extra text : authors list All articles with unsourced statements Articles with unsourced statements from March 2016 Articles with unsourced statements from September 2017 Articles with unsourced statements from January 2011 Talk Contents About Wikipedia Afrikaans Asturianu Беларуская Български Bosanski Català Čeština Cymraeg Dansk Deutsch Eesti Ελληνικά Español Esperanto Euskara فارسی Français Gaeilge Galego 한국어 Հայերեն हिन्दी Hrvatski Ido Bahasa Indonesia Interlingua Italiano עברית Basa Jawa ქართული Қазақша Kurdî Latina Latviešu Lietuvių Magyar മലയാളം Bahasa Melayu Nederlands 日本 語 Norsk Norsk nynorsk Oʻzbekcha / ўзбекча Plattdüütsch Polski Português Română Русский Scots Simple English Slovenčina Slovenščina کوردی Српски / srpski Srpskohrvatski / српскохрватски Basa Sunda Suomi Svenska தமிழ் Татарча / tatarça తెలుగు ไทย Тоҷикӣ Türkçe Українська اردو Tiếng Việt 粵語 中文 61 more Edit links This page was last edited on 25 April 2018, at 19 : 20. 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Question: name the tissue type of the inner most layer of cells
Answer: Epithelium