Dynamin - wikipedia Dynamin Dynamin family Structure of the nucleotide - free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin I from Rattus norvegicus Identifiers Symbol Dynamin_N Pfam PF00350 Pfam clan CL0023 InterPro IPR001401 PROSITE PDOC00362 Available protein structures : Pfam structures PDB RCSB PDB ; PDBe ; PDBj PDBsum structure summary Dynamin central region Structure of the nucleotide - free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin I from Rattus norvegicus Identifiers Symbol Dynamin_M Pfam PF01031 InterPro IPR000375 Available protein structures : Pfam structures PDB RCSB PDB ; PDBe ; PDBj PDBsum structure summary Dynamin is a GTPase responsible for endocytosis in the eukaryotic cell. Dynamins are principally involved in the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartment, both at the cell surface ( particularly caveolae internalization ) as well as at the Golgi apparatus. Dynamin also plays a role in many processes including division of organelles, cytokinesis and microbial pathogen resistance. Dynamin is part of the `` dynamin superfamily, '' which includes classical dynamins, dynamin - like proteins, Mx proteins, OPA, mitofusins, and GBPs. Dynamin itself is a 96 kDa enzyme, and was first isolated when researchers were attempting to isolate new microtubule - based motors from the bovine brain. Dynamin has been extensively studied in the context of clathrin - coated vesicle budding from the cell membrane. Contents 1 Function 2 Types 3 Disease implications 4 References 5 External links Function As a vesicle invaginates, dynamin polymerizes into a helical tube around the neck of the vesicle. The polymer constricts the underlying membrane upon GTP binding and hydrolysis. Constriction around the vesicle neck leads to membrane fission and results in the pinching off of the vesicle from the parent membrane. An example of this process is clathrin - mediated endocytosis. To view a ' cartoon ' image of the non-constricted and constricted state of dynamin spirals, please follow this link : http://dynamin.niddk.nih.gov/figure5.html. The first structure on the left is dynamin in its relaxed state. The structure on the right is dynamin in its constricted state. This shows the extent to which dynamin tightens and changes when GTP is converted to GDP. This constriction is in part the result of the twisting activity of dynamin. This twisting required GTP hydrolysis. Dynamin is the only molecular motor known to have a twisting activity. Dynamin is a right - handed helix and has a right - handed twisting activity that explains its tightening and the reduction in the pitch of the helix described above. Types In mammals, three different dynamin genes have been identified : Dynamin I is expressed in neurons and neuroendocrine cells Dynamin II is expressed in most cell types Dynamin III is strongly expressed in the testis, but is also present in heart, brain, and lung tissue. Disease implications Mutations in Dynamin II have been found to cause dominant intermediate Charcot - Marie - Tooth disease. Epileptic encephalopathy -- causing de novo mutations in dynamin have been suggested to cause dysfunction of vesicle scission during synaptic vesicle endocytosis. References ^ Jump up to : Henley, J.R. ; Cao, H. ; McNicven, M.A. ( 1999 ). `` Participation of dynamin in the biogenesis of cytoplasmic vesicles ''. The FASEB Journal. 13 ( 9002 ) : S243 -- S247. ^ Jump up to : Hinshaw, J. `` Research statement, Jenny E. Hinshaw, Ph. D. '' National Institute of Diabetes & Digestive & Kidney Diseases, Laboratory of Cell Biochemistry and Biology. Accessed 19 March 2013. ^ Jump up to : Urrutia, R. ; Henley, J.R. ; Cook, T. ; McNiven, M.A. ( 1997 ). `` The dynamins : Redundant or distinct functions for an expanding family of related GTPases ? ''. Proc. Natl. Acad. Sci. USA. 94 ( 2 ) : 377 -- 384. doi : 10.1073 / pnas. 94.2. 377. Jump up ^ Thoms S, Erdmann R ( Oct 2005 ). `` Dynamin - related proteins and Pex11 proteins in peroxisome division and proliferation ''. FEBS J. 272 ( 20 ) : 5169 -- 81. doi : 10.1111 / j. 1742 - 4658.2005. 04939. x. PMID 16218949. ^ Jump up to : McMahon. ( 2004 ). Researching Endocytic Mechanisms : Dynamin. Accompaniment to Nature Reviews Molecular Cell Biology, 5, 133 - 147. Jump up ^ Roux, A ; Uyhazi, K ; Frost, A ; De Camilli, P ( 2006 - 04 - 30 ). `` GTP - dependent twisting of dynamin implicates constriction and tension in membrane fission ''. Nature. 441 ( 7092 ) : 528 -- 31. doi : 10.1038 / nature04718. PMID 16648839. Jump up ^ Stephan Zuchner, Maher Noureddine, Marina Kennerson, Kristien Verhoeven, Kristl Claeys, Peter De Jonghe, John Merory, Sofia A. Oliveira, Marcy C. Speer, Judith E. Stenger, Gina Walizada, Danqing Zhu, Margaret A. Pericak - Vance, Garth Nicholson, Vincent Timmerman & Jeffery M. Vance ( March 2005 ). `` Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot - Marie - Tooth disease ''. Nature Genetics. 37 ( 3 ) : 289 -- 294. doi : 10.1038 / ng1514. PMID 15731758. CS1 maint : Multiple names : authors list ( link ) Jump up ^ Dhindsa, R ; Bradrick, S ; Yao, Y ; Heinzen, E ; Petrovski, S ; Krueger, B ; Johnson, M ; Frankel, F ; Petrou, S ; Boumil, R ; Goldstein, D ( 2015 - 06 - 15 ). `` Epileptic encephalopathy - causing mutations in DNM1 impair synaptic vesicle endocytosis ''. Neurology Genetics. 1 ( 1 ) : 3 -- 9. External links Wikimedia Commons has media related to Dynamins. Dynamins at the US National Library of Medicine Medical Subject Headings ( MeSH ) Membrane protein : vesicular transport proteins ( TC 1F ) Synaptic vesicle SNARE Q - SNARE SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc - 18 : STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6 R - SNARE Synaptobrevin / VAMP : VAMP1 VAMP2 VAMP3 Synaptotagmin SYT1 SYT2 SYT3 SYT4 SYT5 SYT6 SYT7 SYT8 SYT9 SYT10 SYT11 SYT12 SYT13 SYT14 SYT15 SYT16 SYT17 Other Synaptophysin Synapsin Small GTPase : RAB3A COPI Coatomer COPA COPB1 COPB2 COPD / Archain COPE COPG COPG2 COPZ1 COPZ2 Small GTPase : ARF COPII Coatomer SEC23A / SEC24A SEC13 / SEC31 Small GTPase : SAR1A RME / Clathrin CLTA CLTB CLTC Caveolae Caveolin ( CAV1 CAV2 CAV3 ) Other / ungrouped Vesicle formation Adaptor protein complex 1 : AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 Adaptor protein complex 2 : AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 Adaptor protein complex 3 : AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2 Adaptor protein complex 4 : AP4B1 AP4E1 AP4M1 AP4S1 LMAN1 LYST BLOC - 1 : DTNBP1 BLOC153 BLOC - 2 : HPS3 HPS5 HPS6 BLOC - 3 : HPS1 HPS4 Coats : Retromer TIP47 Small GTPase Dynamin DNM1 DNM2 DNM3 Other EHD protein family : EHD1 EHD2 EHD3 EHD4 Sorting nexins Vacuolar protein sorting : VPS13B VPS33B SYNRG See also vesicular transport protein disorders Proteins of the cytoskeleton Human Microfilaments and ABPs Myofilament Actins A1 A2 C1 G1 G2 Myosins MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H ) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1 Other Tropomodulin Troponin Tropomyosin Actinin Arp2 / 3 complex actin depolymerizing factors Cofilin Destrin Gelsolin Profilin Titin Other Wiskott - Aldrich syndrome protein Fibrillin Filamin FLNA FLNB FLNC Espin TRIOBP Intermediate filaments Type 1 / 2 ( Keratin, Cytokeratin ) Epithelial keratins ( soft alpha - keratins ) type I / chromosome 17 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II / chromosome 12 2A 5 6A 6B 7 8 9 Hair keratins ( hard alpha - keratins ) type I / chromosome 17 31 32 33A 33B 34 35 36 37 38 type II / chromosome 12 81 82 83 84 85 86 Ungrouped alpha chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80 Not alpha Beta - keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins : A / C B1 B2 Microtubules and MAPs Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3 Dyneins axonemal : DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic : DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Other Tau protein Dynactin DCTN1 Tubulins TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3 Catenins Alpha catenin Beta catenin APC Plakoglobin ( gamma catenin ) Delta catenin GAN Membrane Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin Dystonin Envoplakin MACF1 Periplakin Plectin Talin TLN1 Vinculin Plakophilin PKP1 PKP2 Nonhuman Major sperm proteins Prokaryotic cytoskeleton Crescentin FtsZ MreB See also : cytoskeletal defects Hydrolases : acid anhydride hydrolases ( EC 3.6 ) 3.6. 1 Pyrophosphatase Inorganic Thiamine Apyrase Thiamine - triphosphatase 3.6. 2 Adenylylsulfatase Phosphoadenylylsulfatase 3.6. 3 - 4 : ATPase 3.6. 3 Cu++ ( 3.6. 3.4 ) Menkes / ATP7A Wilson / ATP7B Ca+ ( 3.6. 3.8 ) SERCA ATP2A1 ATP2A2 ATP2A3 Plasma membrane ATP2B1 ATP2B2 ATP2B3 ATP2B4 SPCA ATP2C1 ATP2C2 Na+ / K+ ( 3.6. 3.9 ) ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP1B4 H+ / K+ ( 3.6. 3.10 ) ATP4A Other P - type ATPase ATP8B1 ATP10A ATP11B ATP12A ATP13A2 ATP13A3 3.6. 4 Dynein Kinesin Myosin Katanin 3.6. 5 : GTPase 3.6. 5.1 : Heterotrimeric G protein GNAI1 GNAI2 GNAI3 GNAQ GNA11 GNA12 GNA13 Transducin GNAT1 GNAT2 Gustducin GNAT3 3.6. 5.2 : Small GTPase > Ras superfamily Rho family of GTPases : Cdc42 CDC42 TC10 TCL RhoUV RhoU RhoV Rac Rac1 RhoG RhoBTB RhoH Rho Rnd RhoDF RhoF RhoD other : Ras HRAS KRAS NRAS Rab RAB23 RAB27 Arf ARF6 SAR1B ARL13B ARL6 Ran Rheb Rap RGK 3.6. 5.3 : Protein - synthesizing GTPase Prokaryotic IF - 2 EF - Tu EF - G Eukaryotic 3.6. 5.5 - 6 : Polymerization motors Dynamin Tubulin Enzymes Activity Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Regulation Allosteric regulation Cooperativity Enzyme inhibitor Classification EC number Enzyme superfamily Enzyme family List of enzymes Kinetics Enzyme kinetics Eadie -- Hofstee diagram Hanes -- Woolf plot Lineweaver -- Burk plot Michaelis -- Menten kinetics Types EC1 Oxidoreductases ( list ) EC2 Transferases ( list ) EC3 Hydrolases ( list ) EC4 Lyases ( list ) EC5 Isomerases ( list ) EC6 Ligases ( list ) Molecular and Cellular Biology portal Retrieved from `` https://en.wikipedia.org/w/index.php?title=Dynamin&oldid=791031306 '' Categories : Cellular processes EC 3.6. 5 Hidden categories : CS1 maint : Multiple names : authors list Talk Contents About Wikipedia Bosanski Català Čeština Deutsch Español Français Português Русский Српски / srpski Srpskohrvatski / српскохрватски 3 more Edit links This page was last edited on 17 July 2017, at 17 : 57. 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Question: dynamin is associated with which type of vesicle
Answer: the scission of newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartment, both at the cell surface (particularly caveolae internalization) as well as at the Golgi apparatus; newly formed vesicles from the membrane of one cellular compartment and their targeting to, and fusion with, another compartment, both at the cell surface (particularly caveolae internalization) as well as at the Golgi apparatus; clathrin-coated vesicle budding from the cell membrane; newly formed vesicles