The dose makes the poison - wikipedia The dose makes the poison For the book, see The Dose Makes the Poison. Alle Dinge sind Gift, und nichts ist ohne Gift, allein die Dosis macht dass ein Ding kein Gift ist. All things are poison, and nothing is without poison, the dosage alone makes it so a thing is not a poison. -- Paracelsus `` The dose makes the poison '' ( Latin : sola dosis facit venenum ) is an adage intended to indicate a basic principle of toxicology. It is credited to Paracelsus who expressed the classic toxicology maxim `` All things are poison and nothing is without poison ; only the dose makes a thing not a poison. '' This is often condensed to : `` The dose makes the poison '' or in Latin, `` Sola dosis facit venenum ''. It means that a substance can produce the harmful effect associated with its toxic properties only if it reaches a susceptible biological system within the body in a high enough concentration ( i.e., dose ). The principle relies on the finding that all chemicals -- even water and oxygen -- can be toxic if too much is eaten, drunk, or absorbed. `` The toxicity of any particular chemical depends on many factors, including the extent to which it enters an individual 's body. '' This finding provides also the basis for public health standards, which specify maximum acceptable concentrations of various contaminants in food, public drinking water, and the environment. However, there is no linear relationship and also more to chemical toxicity than the acute effects caused by short - term exposure. Relatively low doses of contaminants in water, food, and environment can already have significant chronic effects if there is a long - term exposure. Many pollutants, drugs, and natural substances adhere to this principle by causing different effects at different levels, which can as a result lead to health standards that are either too strong or too weak. Generally the effects of different doses can be very different at different levels ( not only bigger and smaller impacts depending on dose ). Very low doses of some compounds can even induce stronger toxic responses than much higher doses as well as just different impacts. Toxic substances and the law `` Regulators must extrapolate results not only from animal toxicity studies, typically from mice and / or rats to humans, but also from the very high doses usually used in animal experiments to the very low doses that are characteristic of human exposure. These two types of extrapolation are steeped in uncertainty, '' wrote Edward J. Calabrese, Professor of Toxicology at the University of Massachusetts Amherst ' School of Public Health in Amherst, MA. See also Hormesis Dose concentration Notes Jump up ^ `` Die dritte Defension wegen des Schreibens der neuen Rezepte, '' Septem Defensiones 1538. Werke Bd. 2, Darmstadt 1965, p. 510 ( full text ) Jump up ^ The Dose Makes the Poison on Chemsafe at Yale Archived 2011 - 02 - 02 at the Wayback Machine. ^ Jump up to : Nancy Trautmann : The Dose Makes the Poison -- Or Does It ?, Bioscience 2005, American Institute of Biological Sciences Jump up ^ Pete Myers, Ph. D. and Wendy Hessle, `` Does ' the dose make the poison ? ' '', ourstolenfuture.org Jump up ^ Hormesis : a revolution in toxicology, risk assessment and medicine EMBO Rep. 2004 October ; 5 ( Suppl 1 ) : pp. 37 -- 40. doi : 10.1038 / sj. embor. 7400222. Toxicology History of poison Toxinology Fields Aquatic toxicology Ecotoxicology Occupational toxicology Entomotoxicology Environmental toxicology Forensic toxicology Medical toxicology In vitro toxicology Toxicogenomics Concepts Acceptable daily intake Acute toxicity Bioaccumulation Biomagnification Fixed - dose procedure Lethal dose Poison Toxic capacity Toxicant Toxin Toxicity class Venom Treatments Activated carbon Antidote Cathartic Chelation therapy Gastric lavage Hemodialysis Hemoperfusion Whole bowel irrigation Incidents 1858 Bradford sweets poisoning 2007 pet food recalls Bhopal disaster Minamata disease Niigata Minamata disease Poisoning of Alexander Litvinenko Seveso disaster Consumption of Tide Pods List of poisonings Related topics Biological warfare Carcinogen Food safety Hazard symbol List of extremely hazardous substances Mutagen Occupational safety and health Commons WikiProject Retrieved from `` https://en.wikipedia.org/w/index.php?title=The_dose_makes_the_poison&oldid=837465672 '' Categories : Toxicology Paracelsus Phrases Hidden categories : Webarchive template wayback links Articles containing Latin - language text Talk About Wikipedia Add links This page was last edited on 21 April 2018, at 00 : 37. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: who said the poison is in the dose
Answer: Paracelsus; Paracelsus; Paracelsus; credited to Paracelsus; Paracelsus