Malonyl - CoA - wikipedia Malonyl - CoA Malonyl - CoA Identifiers CAS Number 524 - 14 - 1 ChemSpider 10213 ECHA InfoCard 100.007. 596 MeSH Malonyl + CoA PubChem CID 869 InChI InChI = 1S / C24H38N7O19P3S / c1 - 24 ( 2, 19 ( 37 ) 22 ( 38 ) 27 - 4 - 3 - 13 ( 32 ) 26 - 5 - 6 - 54 - 15 ( 35 ) 7 - 14 ( 33 ) 34 ) 9 - 47 - 53 ( 44, 45 ) 50 - 52 ( 42, 43 ) 46 - 8 - 12 - 18 ( 49 - 51 ( 39, 40 ) 41 ) 17 ( 36 ) 23 ( 48 - 12 ) 31 - 11 - 30 - 16 - 20 ( 25 ) 28 - 10 - 29 - 21 ( 16 ) 31 / h10 - 12, 17 - 19, 23, 36 - 37H, 3 - 9H2, 1 - 2H3, ( H, 26, 32 ) ( H, 27, 38 ) ( H, 33, 34 ) ( H, 42, 43 ) ( H, 44, 45 ) ( H2, 25, 28, 29 ) ( H2, 39, 40, 41 ) / t12 -, 17 -, 18 -, 19 ?, 23 - / m1 / s1 Key : LTYOQGRJFJAKNA - VFLPNFFSSA - N Properties Chemical formula Molar mass 853.582 Except where otherwise noted, data are given for materials in their standard state ( at 25 ° C ( 77 ° F ), 100 kPa ). Y verify ( what is ? ) Infobox references Malonyl - CoA is a coenzyme A derivative of malonic acid. Contents 1 Functions 1.1 Fatty acid biosynthesis 1.2 Polypeptide biosynthesis 1.3 Regulation 2 See also 3 References 4 External links Functions It plays a key role in chain elongation in fatty acid biosynthesis and polyketide biosynthesis. Fatty acid biosynthesis In the former, it provides 2 - carbon units to fatty acids and commits them to fatty acid chain synthesis. Malonyl - CoA is formed by carboxylating acetyl - CoA using the enzyme acetyl - CoA carboxylase. One molecule of acetyl - CoA joins with a molecule of bicarbonate, requiring energy rendered from ATP. Malonyl - CoA is utilised in fatty acid biosynthesis by the enzyme malonyl coenzyme A : acyl carrier protein transacylase ( MCAT ). MCAT serves to transfer malonate from malonyl - CoA to the terminal thiol of holo - acyl carrier protein ( ACP ). Polypeptide biosynthesis MCAT is also involved in bacterial polyketide biosynthesis. The enzyme MCAT together with an acyl carrier protein ( ACP ), and a polyketide synthase ( PKS ) and chain - length factor heterodimer, constitutes the minimal PKS of type II polyketides. Regulation Malonyl - CoA is a highly regulated molecule in fatty acid synthesis ; as such, it inhibits the rate - limiting step in beta - oxidation of fatty acids. Malonyl CoA inhibits fatty acids from associating with carnitine by regulating the enzyme carnitine acyltransferase, thereby preventing them from entering the mitochondria, where fatty acid oxidation and degradation occur. See also Malonyl - CoA decarboxylase Malonyl - CoA decarboxylase deficiency References Jump up ^ Nelson D, Cox M ( 2008 ) Lehninger principles of biochemistry. 5th Ed : p. 806 External links Hope for new way to beat obesity Fatty - acid metabolic intermediates Synthesis Acetyl - CoA Malonyl - CoA Degradation Acyl - CoA Acetyl - CoA Peroxisomal Phytol Phytanic acid Phytanoyl - CoA Pristanic acid Propionyl - CoA Other Mevalonic acid Very long chain fatty acid Metabolism portal Retrieved from `` https://en.wikipedia.org/w/index.php?title=Malonyl-CoA&oldid=818838877 '' Categories : Metabolism Thioesters of coenzyme A Hidden categories : Articles without InChI source Articles without EBI source Articles without KEGG source Articles without UNII source ECHA InfoCard ID from Wikidata Articles containing unverified chemical infoboxes Talk Contents About Wikipedia تۆرکجه Català Deutsch Español فارسی Français Galego Italiano 日本 語 Português Српски / srpski Srpskohrvatski / српскохрватски 中文 Edit links This page was last edited on 5 January 2018, at 22 : 06. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: role of malonyl coa in fatty acid synthesis
Answer: chain elongation