Aortic dissection - wikipedia Aortic dissection Aortic dissection Dissection of the descending part of the aorta ( 3 ), which starts from the left subclavian artery and extends to the abdominal aorta ( 4 ). The ascending aorta ( 1 ) and aortic arch ( 2 ) are not involved. Specialty Vascular surgery, cardiothoracic surgery Symptoms severe chest or back pain, vomiting, sweating, lightheadedness Complications Stroke, mesenteric ischemia, myocardial ischemia, aortic rupture Usual onset Sudden Risk factors High blood pressure, Marfan syndrome, bicuspid aortic valve, previous heart surgery, major trauma, smoking Diagnostic method Medical imaging Prevention Blood pressure control, not smoking Treatment Depends on the type Prognosis Mortality without treatment 10 % ( type B ), 50 % ( type A ) Frequency 3 per 100,000 per year ( edit on Wikidata ) Aortic dissection occurs when an injury to the innermost layer of the aorta allows blood to flow between the layers of the aortic wall, forcing the layers apart. In most cases this is associated with a sudden onset of severe chest or back pain, often described as `` tearing '' in character. Also, vomiting, sweating, and lightheadedness may occur. Other symptoms may result from decreased blood supply to other organs such as stroke or mesenteric ischemia. Aortic dissection can quickly lead to death from not enough blood flow to the heart or rupture of the aorta. Aortic dissection is more common in those with a history of high blood pressure, a number of connective tissue diseases that affect blood vessel wall strength such as Marfan syndrome, a bicuspid aortic valve, and previous heart surgery. Major trauma, smoking, cocaine use, pregnancy, a thoracic aortic aneurysm, inflammation of arteries, and abnormal lipid levels are also associated with an increased risk. The diagnosis is suspected based on symptoms with medical imaging such as computed tomography, magnetic resonance imaging, or ultrasound used to confirm and further evaluate the dissection. The two main types are Stanford type A which involves the first part of the aorta and type B which does not. Prevention is by blood pressure control and not smoking. The treatment of aortic dissection depends on the part of the aorta involved. Surgery is usually required for dissections that involve the first part of the aorta, while those that do not can typically be treated with blood pressure and heart - rate lowering unless complications result. Surgery may be done either by an opening in the chest or by endovascular aneurysm repair ( carried out from inside the blood vessels ). Aortic dissection is relatively rare, occurring at an estimated rate of three per 100,000 people per year. It is more common in males than females. The typical age at diagnosis is 63, with about 10 % of cases occurring before 40. Without treatment, about half of people with type A die within three days and about 10 % of people with type B die within a month. The first case of aortic dissection described was in the examination of King George II of Great Britain following his death in 1760. Surgery for aortic dissection was introduced in the 1950s by Michael E. DeBakey. Play media Video explanation Contents 1 Signs and symptoms 1.1 Blood pressure 1.2 Aortic insufficiency 1.3 Myocardial infarction 1.4 Pleural effusion 2 Causes 3 Pathophysiology 4 Diagnosis 4.1 D - dimer 4.2 Chest X-ray 4.3 Computed tomography 4.4 MRI 4.5 Ultrasound 4.6 Aortogram 4.7 Classification 4.7. 1 DeBakey 4.7. 2 Stanford 5 Prevention 6 Management 6.1 Medication 6.2 Surgical 6.3 Follow - up 7 Epidemiology 8 Prognosis 9 History 10 Society and culture 10.1 Ritter rules 11 References 12 External links Signs and symptoms About 96 % of individuals with aortic dissection present with severe pain that had a sudden onset. The pain may be described as a tearing, stabbing, or sharp sensation ; 17 % of individuals feel the pain migrate as the dissection extends down the aorta. The location of pain is associated with the location of the dissection. Anterior chest pain is associated with dissections involving the ascending aorta, while interscapular ( back ) pain is associated with descending aortic dissections. If the pain is pleuritic in nature, it may suggest acute pericarditis caused by bleeding into the pericardial sac. This is a particularly dangerous eventuality, suggesting that acute pericardial tamponade may be imminent. Pericardial tamponade is the most common cause of death from aortic dissection. While the pain may be confused with the pain of a myocardial infarction ( heart attack ), aortic dissection is usually not associated with the other signs that suggest myocardial infarction, including heart failure and ECG changes. Individuals with aortic dissection who do not present with pain have a chronic dissection. Less common symptoms that may be seen in the setting of aortic dissection include congestive heart failure ( 7 % ), fainting ( 9 % ), stroke ( 6 % ), ischemic peripheral neuropathy, paraplegia, and cardiac arrest. If the individual had a fainting episode, about half the time it is due to bleeding into the pericardium leading to pericardial tamponade. Neurological complications of aortic dissection ( i.e., stroke and paralysis ) are due to the involvement of one or more arteries supplying portions of the central nervous system. If the aortic dissection involves the abdominal aorta, compromise of the branches of the abdominal aorta is possible. In abdominal aortic dissections, compromise of one or both renal arteries occurs in 5 -- 8 % of cases, while mesenteric ischemia ( ischemia of the large intestines ) occurs 3 -- 5 % of the time. Blood pressure People with an aortic dissection often have a history of high blood pressure ; the blood pressure is quite variable at presentation with acute aortic dissection, and tends to be higher in individuals with a distal dissection. In individuals with a proximal aortic dissection, 36 % present with hypertension, while 25 % present with hypotension. Proximal aortic dissections tend to be more associated with weakening of the vascular wall due to cystic medial degeneration. In those who present with distal aortic dissections, 70 % present with high blood pressure, while 4 % present with low blood pressure. Severe hypotension at presentation is a grave prognostic indicator. It is usually associated with pericardial tamponade, severe aortic insufficiency, or rupture of the aorta. Accurate measurement of the blood pressure is important. Pseudohypotension ( falsely low blood - pressure measurement ) may occur due to involvement of the brachiocephalic artery ( supplying the right arm ) or the left subclavian artery ( supplying the left arm ). Aortic insufficiency Aortic insufficiency ( AI ) occurs in half to two - thirds of ascending aortic dissections, and the murmur of aortic insufficiency is audible in about 32 % of proximal dissections. The intensity ( loudness ) of the murmur is dependent on the blood pressure and may be inaudible in the event of hypotension. Multiple causes exist for AI in the setting of ascending aortic dissection. The dissection may dilate the annulus of the aortic valve, so that the leaflets of the valve can not coapt. Another mechanism is that the dissection may extend into the aortic root and detach the aortic valve leaflets. The third mechanism is that if there was an extensive intimal tear, the intimal flap may prolapse into the LV outflow tract, causing intimal intussusception into the aortic valve preventing proper valve closure. Myocardial infarction Myocardial infarction ( heart attack ) occurs in 1 -- 2 % of aortic dissections. The cause of the infarction is involvement of the coronary arteries, which supply the heart, in the dissection. The right coronary artery is involved more commonly than the left coronary artery. If the myocardial infarction is treated with thrombolytic therapy, the mortality increases to over 70 %, mostly due to bleeding into the pericardial sac causing pericardial tamponade. Because aortic dissection may present to the emergency room physician similar to a myocardial infarction, the physician must be careful to make the proper diagnosis prior to initiating treatment for myocardial infarction since the treatment regimen for myocardial infarction can be lethal to an individual presenting with aortic dissection. Pleural effusion A pleural effusion ( fluid collection in the space between the lungs and the chest wall or diaphragm ) can be due to either blood from a transient rupture of the aorta or fluid due to an inflammatory reaction around the aorta. If a pleural effusion were to develop due to an aortic dissection, it is more commonly in the left hemithorax rather than the right hemithorax. Causes Aortic dissection is associated with hypertension ( high blood pressure ) and many connective tissue disorders. Vasculitis ( inflammation of an artery ) is rarely associated with aortic dissection. It can also be the result of chest trauma. About 72 to 80 % of individuals who present with an aortic dissection have a previous history of hypertension. A bicuspid aortic valve ( a type of congenital heart disease involving the aortic valve ) is found in 7 -- 14 % of individuals who have an aortic dissection. These individuals are prone to dissection in the ascending aorta. The risk of dissection in individuals with bicuspid aortic valve is not associated with the degree of stenosis of the valve. Marfan syndrome is noted in 5 -- 9 % of individuals who suffer from an aortic dissection. In this subset, the incidence in young individuals is increased. Individuals with Marfan syndrome tend to have aneurysms of the aorta and are more prone to proximal dissections of the aorta. Turner syndrome also increases the risk of aortic dissection, by aortic root dilatation. Chest trauma leading to aortic dissection can be divided into two groups based on cause : blunt chest trauma ( commonly seen in car accidents ) and iatrogenic. Iatrogenic causes include trauma during cardiac catheterization or due to an intra-aortic balloon pump. Aortic dissection may be a late sequela of cardiac surgery. About 18 % of individuals who present with an acute aortic dissection have a history of open - heart surgery. Individuals who have undergone aortic valve replacement for aortic insufficiency are at particularly high risk because aortic insufficiency causes increased blood flow in the ascending aorta. This can cause dilatation and weakening of the walls of the ascending aorta. Syphilis only potentially causes aortic dissection in its tertiary stage. Pathophysiology Blood penetrates the intima and enters the media layer. As with all other arteries, the aorta is made up of three layers, the intima, the media, and the adventitia. The intima is in direct contact with the blood inside the vessel, and mainly consists of a layer of endothelial cells on a basement membrane ; the media contains connective and muscle tissue, and the vessel is protected on the outside by the adventitia, comprising connective tissue. In an aortic dissection, blood penetrates the intima and enters the media layer. The high pressure rips the tissue of the media apart along the laminated plane splitting the inner two - thirds and the outer one - third of the media apart. This can propagate along the length of the aorta for a variable distance forward or backwards. Dissections that propagate towards the iliac bifurcation ( with the flow of blood ) are called anterograde dissections and those that propagate towards the aortic root ( opposite of the flow of blood ) are called retrograde dissections. The initial tear is usually within 100 mm of the aortic valve, so a retrograde dissection can easily compromise the pericardium leading to a hemopericardium. Anterograde dissections may propagate all the way to the iliac bifurcation of the aorta, rupture the aortic wall, or recanalize into the intravascular lumen leading to a double - barrel aorta. The double - barrel aorta relieves the pressure of blood flow and reduces the risk of rupture. Rupture leads to hemorrhaging into a body cavity, and prognosis depends on the area of rupture. Retroperitoneal and pericardial ruptures are both possible. Histopathological image of dissecting aneurysm of thoracic aorta in a patient without evidence of Marfan syndrome : The damaged aorta was surgically removed and replaced by artificial vessel, Victoria blue & HE stain. The initiating event in an aortic dissection is a tear in the intimal lining of the aorta. Due to the high pressures in the aorta, blood enters the media at the point of the tear. The force of the blood entering the media causes the tear to extend. It may extend proximally ( closer to the heart ) or distally ( away from the heart ) or both. The blood travels through the media, creating a false lumen ( the true lumen is the normal conduit of blood in the aorta ). Separating the false lumen from the true lumen is a layer of intimal tissue known as the intimal flap. The vast majority of aortic dissections originate with an intimal tear in either the ascending aorta ( 65 % ), the aortic arch ( 10 % ), or just distal to the ligamentum arteriosum in the descending thoracic aorta ( 20 % ). As blood flows down the false lumen, it may cause secondary tears in the intima. Through these secondary tears, the blood can re-enter the true lumen. While it is not always clear why an intimal tear may occur, quite often it involves degeneration of the collagen and elastin that make up the media. This is known as cystic medial necrosis and is most commonly associated with Marfan syndrome and is also associated with Ehlers - Danlos syndrome. In about 13 % of aortic dissections, no evidence of an intimal tear is found. In these cases, the inciting event is thought to be an intramural hematoma ( caused by bleeding within the media ). Since no direct connection exists between the true lumen and the false lumen in these cases, diagnosing an aortic dissection by aortography is difficult if the cause is an intramural hematoma. An aortic dissection secondary to an intramural hematoma should be treated the same as one caused by an intimal tear. Diagnosis Because of the varying symptoms and signs of aortic dissection depending on the initial intimal tear and the extent of the dissection, the proper diagnosis is sometimes difficult to make. While taking a good history from the individual may be strongly suggestive of an aortic dissection, the diagnosis can not always be made by history and physical signs alone. Often, the diagnosis is made by visualization of the intimal flap on a diagnostic imaging test. Common tests used to diagnose an aortic dissection include a CT scan of the chest with iodinated contrast material and a transesophageal echocardiogram. The proximity of the aorta to the esophagus allows the use of higher - frequency ultrasound for better anatomical images. Other tests that may be used include an aortogram or magnetic resonance angiogram of the aorta. Each of these tests has pros and cons, and they do not have equal sensitivities and specificities in the diagnosis of aortic dissection. In general, the imaging technique chosen is based on the pretest likelihood of the diagnosis, availability of the testing modality, patient stability, and the sensitivity and specificity of the test. D - dimer A measurement of blood D - dimer level may be useful in diagnostic evaluation. A level less than 500 ng / ml may be considered evidence against a diagnosis of aortic dissection, although this guideline is only applicable in cases deemed `` low risk '' and within 24 hours of symptom onset. The American Heart Association does not advise using this test in making the diagnosis, as evidence is still tentative. Chest x-ray Aortic dissection on CXR : Note is made of a wide aortic knob. Chest radiography may demonstrate a change in the morphology of the thoracic aorta which can be seen in aortic dissection. Classically, new widening of the mediastinum on radiograph is of moderate sensitivity for detecting an ascending aortic dissection ; however, this finding is of low specificity, as many other conditions can cause apparent widening of the mediastinum. There are several other associated radiographic findings : The `` calcium sign '' describes an apparent separation of the intimal calcification from the outer aortic margin by greater than 10 mm. Pleural effusions, more commonly in descending aortic dissections, and typically left sided. Other : obliteration of the aortic knob, depression of the left mainstem bronchus, loss of the paratracheal stripe, and tracheal deviation. Importantly, about 12 to 20 % of aortic dissections are not detectable by chest radiograph ; therefore, a `` normal '' chest radiograph does not rule out aortic dissection. If there is high clinical suspicion, a more sensitive imaging test ( CT angiogram, MR angiography, or transesophageal echo ) may be warranted. Computed tomography Computed tomography angiography is a fast, noninvasive test that gives an accurate three - dimensional view of the aorta. These images are produced by taking rapid, thin - cut slices of the chest and abdomen, and combining them in the computer to create cross-sectional slices. To delineate the aorta to the accuracy necessary to make the proper diagnosis, an iodinated contrast material is injected into a peripheral vein. Contrast is injected and the scan performed using a bolus tracking method. This type of scan is timed to an injection to capture the contrast as it enters the aorta. The scan then follows the contrast as it flows though the vessel. It has a sensitivity of 96 to 100 % and a specificity of 96 to 100 %. Disadvantages include the need for iodinated contrast material and the inability to diagnose the site of the intimal tear. CT with contrast demonstrating aneurysmal dilation and a dissection of the ascending aorta ( type A Stanford ) Chest CT with descending ( type B Stanford ) aortic dissection ( red circle ) MRI MRI of an aortic dissection 1 Aorta descendens with dissection 2 Aorta isthmus Magnetic resonance imaging ( MRI ) is also used for the detection and assessment of aortic dissection, with a sensitivity of 98 % and a specificity of 98 %. An MRI examination of the aorta produces a three - dimensional reconstruction of the aorta, allowing the physician to determine the location of the intimal tear and the involvement of branch vessels, and to locate any secondary tears. It is a noninvasive test, does not require the use of iodinated contrast material, and can detect and quantitate the degree of aortic insufficiency. The disadvantage of the MRI scan in the face of aortic dissection is that it has limited availability and is often located only in larger hospitals, and the scan is relatively time - consuming, which may be dangerous in people who are already very unwell. Due to the high - intensity magnetic fields used during MRI, it is contraindicated in individuals with metallic implants. In addition, many individuals experience claustrophobia while in the MRI scanning tube. Ultrasound An echocardiogram displaying the true lumen and false lumen of an aortic dissection : In the image to the left, the intimal flap can be seen separating the two lumens. In the image to the right, color flow during ventricular systole suggests that the upper lumen is the true lumen. The transesophageal echocardiogram ( TEE ) is a relatively good test in the diagnosis of aortic dissection, with a sensitivity up to 98 % and a specificity up to 97 %. It has become the preferred imaging modality for suspected aortic dissection. It is a relatively noninvasive test, requiring the individual to swallow the echocardiography probe. It is especially good in the evaluation of AI in the setting of ascending aortic dissection, and to determine whether the ostia ( origins ) of the coronary arteries are involved. While many institutions give sedation during transesophageal echocardiography for added patient comfort, it can be performed in cooperative individuals without the use of sedation. Disadvantages of TEE include the inability to visualize the distal ascending aorta ( the beginning of the aortic arch ), and the descending abdominal aorta that lies below the stomach. A TEE may be technically difficult to perform in individuals with esophageal strictures or varices. Play media Aortic dissection with an intramural hematoma as seen on TEE Play media Type A aortic dissection Play media Type A aortic dissection Play media Dissection of both the thoracic and abdominal aorta Play media Dissection of both the thoracic and abdominal aorta Aortogram Main article : Aortography An aortogram involves placement of a catheter in the aorta and injection of contrast material while taking X-rays of the aorta. The procedure is known as aortography. Previously thought to be the diagnostic gold standard, it has been supplanted by other, less - invasive imaging modalities. Classification Classification of aortic dissection Percentage 60 % 10 -- 15 % 25 -- 30 % Type DeBakey I DeBakey II DeBakey III Stanford A ( Proximal ) Stanford B ( Distal ) Several different classification systems have been used to describe aortic dissections. The systems commonly in use are based on either the anatomy of the dissection or the duration of onset of symptoms prior to presentation. The Stanford system is used more commonly now, as it is more attuned to the management of the patient. DeBakey The DeBakey system, named after cardiothoracic surgeon Michael E. DeBakey, is an anatomical description of the aortic dissection. It categorizes the dissection based on where the original intimal tear is located and the extent of the dissection ( localized to either the ascending aorta or descending aorta or involves both the ascending and descending aorta. Type I -- originates in ascending aorta, and propagates at least to the aortic arch and often beyond it distally. It is most often seen in patients less than 65 years of age and is the most lethal form of the disease. Type II -- originates in the ascending aorta and is confined to it. Type III -- originates in the descending aorta and rarely extends proximally, but will extend distally. It most often occurs in elderly patients with atherosclerosis and hypertension. Stanford The Stanford classification is divided into two groups, A and B, depending on whether the ascending aorta is involved. A -- involves the ascending aorta and / or aortic arch, and possibly the descending aorta. The tear can originate in the ascending aorta, the aortic arch, or more rarely, in the descending aorta. It includes DeBakey types I and II. B -- involves the descending aorta or the arch ( distal to the left subclavian artery ), without the involvement of the ascending aorta. It includes DeBakey type III. The Stanford classification is useful as it follows clinical practice, as type A ascending aortic dissections generally require primary surgical treatment, whereas type B dissections generally are treated medically as initial treatment with surgery reserved for any complications. The reason for surgical repair of type A dissections is that ascending aortic dissections often involve the aortic valve, which, having lost its suspensory support, telescopes down into the aortic root, resulting in aortic incompetence. The valve must be resuspended in order to be reseated, as well as to repair or prevent coronary artery injury. Also, the area of dissection is removed and replaced with a Dacron graft to prevent further dissection from occurring. However, type B dissections are not improved, from a mortality point of view, by the operation, unless leaking, rupture, or compromise to other organs, e.g. kidneys, occurs. Prevention Among the recognized risk factors for aortic dissection, hypertension, dysplipidemia, and smoking are considered preventable risk factors. Repair of an enlargement of the ascending aorta from an aneurysm or previously unrecognized and untreated aortic dissections is recommended when greater than 6 cm ( 2.4 in ) in size to decrease the risk of dissection. Repair may be recommended when greater than 4.5 cm ( 1.8 in ) in size if the person has one of the several connective - tissue disorders or a family history of a ruptured aorta. Management In an acute dissection, treatment choice depends on its location. For Stanford type A ( ascending aortic ) dissection, surgical management is superior to medical management. For uncomplicated Stanford type B ( distal aortic ) dissections ( including abdominal aortic dissections ), medical management is preferred over surgical. The risk of death due to aortic dissection is highest in the first few hours after the dissection begins, and decreases afterward. Because of this, the therapeutic strategies differ for the treatment of an acute dissection compared to a chronic dissection. An acute dissection is one in which the individual presents within the first two weeks. If the individual has managed to survive this window period, his prognosis is improved. About 66 % of all dissections present in the acute phase. Individuals who present two weeks after the onset of the dissection are said to have chronic aortic dissections. These individuals have been self - selected as survivors of the acute episode and can be treated with medical therapy as long as they are stable. Medication Aortic dissection generally presents as a hypertensive emergency, and the prime consideration of medical management is strict blood pressure control. The target blood pressure should be a mean arterial pressure ( MAP ) of 60 to 75 mmHg, or the lowest blood pressure tolerated. Initial decreases should be by about 20 %. Another factor is to reduce the shear - force dP / dt ( force of ejection of blood from the left ventricle ). Long - term management of physical, emotional, and psychological stresses are important to controlling blood pressure. Beta blockers are the first - line treatment for patients with acute and chronic aortic dissection. In acute dissection, rapidly acting, titratable parenteral agents ( such as esmolol, propranolol, or labetalol ) are preferred. Vasodilators such as sodium nitroprusside can be considered for patients with ongoing hypertension, but they should never be used alone, as they generally cause reflex tachycardia. Calcium channel blockers can be used in the treatment of aortic dissection, particularly if a contraindication to the use of beta blockers exists. The calcium channel blockers typically used are verapamil and diltiazem, because of their combined vasodilator and negative inotropic effects. If the individual has refractory hypertension ( persistent hypertension on the maximum doses of three different classes of antihypertensive agents ), an involvement of the renal arteries in the aortic dissection plane should be considered. Surgical Indications for the surgical treatment of aortic dissection include an acute proximal aortic dissection and an acute distal aortic dissection with one or more complications. Complications include compromise of a vital organ, rupture or impending rupture of the aorta, retrograde dissection into the ascending aorta, and a history of Marfan syndrome or Ehlers - Danlos syndrome. The objective in the surgical management of aortic dissection is to resect ( remove ) the most severely damaged segments of the aorta and to obliterate the entry of blood into the false lumen ( both at the initial intimal tear and any secondary tears along the vessel ). While excision of the intimal tear may be performed, it does not significantly change mortality. The particular treatment used depends on the segment or segments of aorta involved. Some treatments are : Open aortic surgery with replacement of the damaged section of aorta with a tube graft ( often made of Dacron ) when no damage to the aortic valve is seen Bentall procedure -- replacement of the damaged section of aorta and replacement of the aortic valve David procedure -- replacement of the damaged section of aorta and reimplantation of the aortic valve Thoracic endovascular aortic repair, a minimally invasive surgical procedure usually combined with on - going medical management Replacement of the damaged section of aorta with a sutureless vascular ring connector - reinforced Dacron graft : The vascular ring connector is a titanic ring used as a stent in the vascular graft to achieve a quick, blood - sealed, and sutureless anastomosis. Two furrows on the surface of the ring are for fixation of the vascular graft and the aorta. The tapes used to tie against the ring provide a larger contact surface area than the traditional stitches, thus it provides stronger anastomosis and better surgical results. A number of comorbid conditions increase the surgical risk of repair of an aortic dissection. These conditions include the following : Prolonged preoperative evaluation ( increased length of time prior to surgery ) Advanced age Comorbid disease states ( e.g. : coronary artery disease ) Aneurysm leakage Cardiac tamponade Shock Past history of myocardial infarction History of kidney failure ( either acute or chronic kidney failure ) Follow - up Closure of the lumen of a Type B aortic dissection following medical management The long - term follow - up in individuals who survive aortic dissection involves strict blood pressure control. The relative risk of late rupture of an aortic aneurysm is 10 times higher in individuals who have uncontrolled hypertension, compared to individuals with a systolic pressure below 130 mmHg. The risk of death is highest in the first two years after the acute event, and individuals should be followed closely during this time period. About 29 % of late deaths following surgery are due to rupture of either a dissecting aneurysm or another aneurysm. In addition, a 17 % to 25 % incidence exists of new aneurysm formation, typically due to dilatation of the residual false lumen. These new aneurysms are more likely to rupture, due to their thinner walls. Serial imaging of the aorta is suggested, with MRI being the preferred imaging technique. Epidemiology Establishing the incidence of aortic dissection has been difficult because many cases are only diagnosed after death ( which may have been attributed to another cause ), and is often initially misdiagnosed. Aortic dissection affects an estimated 2.0 -- 3.5 people per every 100,000 every year. Studies from Sweden suggest that the incidence of aortic dissection may be rising. Men are more commonly affected than women : 65 % of all people with aortic dissection are male. The mean age at diagnosis is 63 years. In females before the age of 40, half of all aortic dissections occur during pregnancy ( typically in the third trimester or early postpartum period ). Prognosis Risk of death in untreated aortic dissection 25 % in first 24 hours 50 % in first 48 hours 75 % in first week 90 % in first month Of all people with aortic dissection, 40 % die immediately and do not reach a hospital in time. Of the remainder, 1 % die every hour, making prompt diagnosis and treatment a priority. Even after diagnosis, 5 -- 20 % die during surgery or in the immediate postoperative period. In ascending aortic dissection, if surgery is decided to be not appropriate, 75 % die within 2 weeks. With aggressive treatment, 30 - day survival for thoracic dissections may be as high as 90 %. History The earliest fully documented case of aortic dissection is attributed to Frank Nicholls in his autopsy report of King George II of Great Britain, who had been found dead on 25 October 1760 ; the report describes dissection of the aortic arch and into the pericardium. The term `` aortic dissection '' was introduced by the French physician J.P. Maunoir in 1802, and René Laennec labelled the condition `` dissecting aneurysm ''. London cardiologist Thomas Bevill Peacock contributed to the understanding of the condition by publishing two series of the cases described in the literature so far : 19 cases in an 1843 review, and 80 in 1863. The characteristic symptom of tearing pain in the chest was recognized in 1855 when a case was diagnosed in life. Surgery for aortic dissection was first introduced and developed by Michael E. DeBakey, Denton Cooley, and Oscar Creech, cardiac surgeons associated with the Baylor College of Medicine, Houston, Texas, in 1954. DeBakey developed aortic dissection himself at age 97 in 2005, and underwent surgery in 2006. Endovascular treatment of aortic dissection was developed in the 1990s. Society and culture Ritter rules Ritter rules are a compilation of reminders, symptoms, and risk factors designed to prevent the misdiagnosis of thoracic aortic dissection. The rules were named for actor John Ritter, who died from a thoracic aortic dissection on September 11, 2003. Ritter was initially misdiagnosed and subsequently treated for a heart attack. The Ritter rules were developed by Dianna Milewicz, of the University of Texas Medical School, Houston, and were jointly published in March 2010 by John Ritter Foundation and the Thoracic Aortic Disease Coalition. References ^ Jump up to : Nienaber, CA ; Clough, RE ( 28 February 2015 ). `` Management of acute aortic dissection. ''. 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Increasing Prevalence and Improved Outcomes Reported in a Nationwide Population - Based Study of More Than 14 000 Cases From 1987 to 2002 ''. Circulation. 114 : 2611 -- 2618. PMID 17145990. doi : 10.1161 / CIRCULATIONAHA. 106.630400. Archived from the original on 2016 - 08 - 07. Jump up ^ Ho M. and Liang D., `` Diseases of the Aorta '', Chap. 11 in Ardehali A., Pérez M. and Wang P. ( eds ), A Practical Approach to Cardiovascular Medicine Archived 2016 - 08 - 18 at the Wayback Machine., John Wiley & Sons, 2013, 352 pp. ISBN 978 - 1 - 4051 - 8039 - 9. Jump up ^ Woo KM, Schneider JI ( November 2009 ). `` High - risk chief complaints I : chest pain -- the big three ''. Emerg. Med. Clin. North Am. 27 ( 4 ) : 685 -- 712, x. PMID 19932401. doi : 10.1016 / j. emc. 2009.07. 007. Jump up ^ Nicholls F ( 1761 ). `` Observations concerning the body of his late majesty ''. Philosophical Transactions of the Royal Society. 52 : 265 -- 274. doi : 10.1098 / rstl. 1761.0052. 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External links Classification V T D ICD - 10 : I71. 0 ICD - 9 - CM : 441.0 OMIM : 607086 DiseasesDB : 805 External resources MedlinePlus : 000181 eMedicine : emerg / 28 Patient UK : Aortic dissection GeneReviews : Thoracic Aortic Aneurysms and Aortic Dissections Wikimedia Commons has media related to Aortic dissection. Cardiovascular disease ( vessels ) ( I70 -- I99, 440 -- 456 ) Arteries, arterioles and capillaries Inflammation Arteritis Aortitis Buerger 's disease Peripheral artery disease Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg 's arteriosclerosis Arteriolosclerosis Hyaline Hyperplastic Cholesterol LDL Oxycholesterol Trans fat Stenosis Carotid artery stenosis Renal artery stenosis Other Aortoiliac occlusive disease Degos disease Erythromelalgia Fibromuscular dysplasia Raynaud 's phenomenon Aneurysm / dissection / pseudoaneurysm torso : Aortic aneurysm Abdominal aortic aneurysm Thoracic aortic aneurysm Aneurysm of sinus of Valsalva Aortic dissection Coronary artery aneurysm head / neck Intracranial aneurysm Intracranial berry aneurysm Carotid artery dissection Vertebral artery dissection Familial aortic dissection Vascular malformation Arteriovenous fistula Arteriovenous malformation Telangiectasia Hereditary hemorrhagic telangiectasia Vascular nevus Cherry hemangioma Halo nevus Spider angioma Veins Inflammation Phlebitis Venous thrombosis / Thrombophlebitis primarily lower limb Deep vein thrombosis abdomen Hepatic veno - occlusive disease Budd -- Chiari syndrome May -- Thurner syndrome Portal vein thrombosis Renal vein thrombosis upper limb / torso Mondor 's disease Paget -- Schroetter disease head Cerebral venous sinus thrombosis Post-thrombotic syndrome Varicose veins Gastric varices Portacaval anastomosis Caput medusae Esophageal varices Hemorrhoid Varicocele Other Chronic venous insufficiency Chronic cerebrospinal venous insufficiency Superior vena cava syndrome Inferior vena cava syndrome Venous ulcer Arteries or veins Angiopathy Macroangiopathy Microangiopathy Embolism Pulmonary embolism Cholesterol embolism Paradoxical embolism Thrombosis Vasculitis Blood pressure Hypertension Hypertensive heart disease Hypertensive emergency Hypertensive nephropathy Essential hypertension Secondary hypertension Renovascular hypertension Benign hypertension Pulmonary hypertension Systolic hypertension White coat hypertension Hypotension Orthostatic hypotension Retrieved from `` https://en.wikipedia.org/w/index.php?title=Aortic_dissection&oldid=804505232 '' Categories : Diseases of the aorta Diseases of arteries, arterioles and capillaries Deaths from aortic dissection Causes of death Medical emergencies Vascular surgery IgG4 - related disease Hidden categories : All articles with dead external links Articles with dead external links from October 2016 Articles with permanently dead external links Webarchive template wayback links All articles with unsourced statements Articles with unsourced statements from March 2015 Articles with unsourced statements from June 2013 RTT RTTEM Talk Contents About Wikipedia Български Català Deutsch Español Français 한국어 Hrvatski Italiano עברית Nederlands नेपाल भाषा 日本 語 ଓଡ଼ିଆ Polski Português Русский Simple English Српски / srpski Srpskohrvatski / српскохрватски Svenska ไทย Українська 中文 Edit links This page was last edited on 9 October 2017, at 13 : 20. 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Question: when would a stanford type b require surgery
Answer: leaking, rupture, or compromise to other organs, e.g. kidneys, occurs