Pacemaker potential - wikipedia Pacemaker potential In the pacemaking cells of the heart ( e.g., the sinoatrial node ), the pacemaker potential ( also called the pacemaker current ) is the slow, positive increase in voltage across the cell 's membrane ( the membrane potential ) that occurs between the end of one action potential and the beginning of the next action potential. This increase in membrane potential is what causes the cell membrane, which typically maintains a resting membrane potential of - 70 mV, to reach the threshold potential and consequently fire the next action potential ; thus, the pacemaker potential is what drives the self - generated rhythmic firing ( automaticity ) of pacemaker cells, and the rate of change ( i.e., the slope ) of the pacemaker potential is what determines the timing of the next action potential and thus the intrinsic firing rate of the cell. In a healthy sinoatrial node ( SAN, a complex tissue within the right atrium containing pacemaker cells that normally determine the intrinsic firing rate for the entire heart ), the pacemaker potential is the main determinant of the heart rate. Because the pacemaker potential represents the non-contracting time between heart beats ( diastole ), it is also called the diastolic depolarization. The amount of net inward current required to move the cell membrane potential during the pacemaker phase is extremely small, in the order of few pAs, but this net flux arises from time to time changing contribution of several currents that flow with different voltage and time dependence. Evidence in support of the active presence of K, Ca, Na channels and Na / K exchanger during the pacemaker phase have been variously reported in the literature, but several indications point to the `` funny '' ( I ) current as one of the most important. ( see funny current ). There is now substantial evidence that also sarcoplasmic reticulum ( SR ) Ca - transients participate to the generation of the diastolic depolarization via a process involving the Na -- Ca exchanger. Contents 1 Distinctions among autonomic foci 2 Pathology 3 Induction 4 Bio-pacemakers 5 References Distinctions among autonomic foci In reality, the heart has several pacemakers known as autonomic foci, each which fires at its own intrinsic rate : SA node : 60 -- 100 bpm Atrial foci : 60 -- 80 bpm Junctional foci : 40 -- 60 bpm Ventricular foci : 20 -- 40 bpm The potentials will normally travel in order SA node → atrial foci → junctional foci → ventricular foci Pacemaker potentials are fired not only by SA node, but also by the other foci. However, the other firing frequencies are slower than the one of the SA node ( as seen above ). Normally, all the foci will end up firing at the SA node rate, not their intrinsic rate. The other foci attempt to fire at their intrinsic rate, but they are activated by the SA node before they can fire. This rapid firing causes all the foci to fire faster than their intrinsic rates, a phenomenon known as overdrive - suppression. Thus, in the normal, healthy heart, only the SA node intrinsic rate is observable. Pathology However, in pathological conditions, the intrinsic rate becomes apparent. Consider a heart attack which damages the region of the heart between the SA node and the atrial foci. SA node → block atrial foci → junctional foci → ventricular foci The other foci will not see the SA node firing ; however, they will see the atrial foci. The heart will now beat at the intrinsic rate of the atrial foci. Induction The firing of the pacemaker cells is induced electrically by reaching the threshold potential of the cell membrane. The threshold potential is the potential an excitable cell membrane, such as a myocyte, must reach in order to induce an action potential. This depolarization is caused by very small net inward currents of calcium ions across the cell membrane, which gives rise to the action potential. Bio-pacemakers Bio-pacemakers are the outcome of a rapidly emerging field of research into a replacement for the electronic pacemaker. The bio-pacemaker turns quiescent myocardial cells ( e.g. atrial cells ) into pacemaker cells. This is achieved by making the cells express a gene which creates a pacemaker current. References Jump up ^ Berne, Robert ; Matthew Levy ; Bruce Koeppen ; Bruce Stanton ( 2004 ). Physiology. Elsevier Mosby. p. 276. ISBN 0 - 8243 - 0348 - 2. Jump up ^ Verkerk AO, van Boren MM, Peters RJ, Broekhuis E, Lam K, Coronel R, de Bakker JM, Tan HR ( October 2007 ). `` Pacemaker current ( I ) f ) ) in the human sinoatrial node ''. Eur Heart J. 28 ( 1 ) : 2472 -- 8. doi : 10.1093 / eurheartj / ehm339. PMID 17823213. Jump up ^ Boron, Walter. F ; Emile Boulpaep ( 2003 ). Medical Physiology. Elsevier Saunders. p. 489. ISBN 0 - 7216 - 0076 - X. Jump up ^ DiFrancesco D ( May 2006 ). `` Funny channels in the control of cardiac rhythm and mode of action of selective blockers ''. Pharmacol. Res. 53 ( 5 ) : 399 -- 406. doi : 10.1016 / j. phrs. 2006.03. 006. PMID 16638640. Jump up ^ Campbell, Neil. A ( 1996 ). Biology. Benjamin Cummings. p. G -- 21. ISBN 0 - 07 - 366175 - 9. Jump up ^ Verkerk AO, van Ginneken AC, Wilders R ( January 2009 ). `` Pacemaker activity of the human sinoatrial node : Role of the hyperpolarization - activated current, I ( f ) ''. Int J Cardiol. 132 ( 3 ) : 318 -- 36. doi : 10.1016 / j. ijcard. 2008.12. 196. PMID 19181406. Jump up ^ Boron, Walter. F ; Emile Boulpaep ( 2003 ). Medical Physiology. Elsevier Saunders. p. 487. ISBN 0 - 7216 - 0076 - X. Jump up ^ Verkerk AO, Zegers JG, Van Ginneken AC, Wilders R ( 2008 ). `` Dynamic action potential clamp as a powerful tool in the development of a gene - based bio-pacemaker ''. Conf Proc IEEE Eng Med Biol Soc. 1 : 133 -- 6. doi : 10.1109 / IEMBS. 2008.4649108. ISBN 978 - 1 - 4244 - 1814 - 5. PMID 19162611. Physiology of the cardiovascular system Heart Cardiac output Cardiac cycle Cardiac output Heart rate Stroke volume Stroke volume End - diastolic volume End - systolic volume Afterload Preload Frank -- Starling law Cardiac function curve Venous return curve Wiggers diagram Pressure volume diagram Ultrasound Fractional shortening = ( End - diastolic dimension End - systolic dimension ) / End - diastolic dimension Aortic valve area calculation Ejection fraction Cardiac index Heart rate Cardiac pacemaker Chronotropic ( Heart rate ) Dromotropic ( Conduction velocity ) Inotropic ( Contractility ) Bathmotropic ( Excitability ) Lusitropic ( Relaxation ) Conduction Conduction system Cardiac electrophysiology Action potential cardiac atrial ventricular Effective refractory period Pacemaker potential Electrocardiography P wave PR interval QRS complex QT interval ST segment T wave U wave Hexaxial reference system Chamber pressure Central venous Right atrial ventricular pulmonary artery wedge Left atrial ventricular Aortic Other Ventricular remodeling Vascular system / Hemodynamics Blood flow Compliance Vascular resistance Pulse Perfusion Blood pressure Pulse pressure Systolic Diastolic Mean arterial pressure Jugular venous pressure Portal venous pressure Regulation of BP Baroreflex Kinin -- kallikrein system Renin -- angiotensin system Vasoconstrictors Vasodilators Autoregulation Myogenic mechanism Tubuloglomerular feedback Cerebral autoregulation Paraganglia Aortic body Carotid body Glomus cell Retrieved from `` https://en.wikipedia.org/w/index.php?title=Pacemaker_potential&oldid=766108983 '' Categories : Cardiac electrophysiology Talk Contents About Wikipedia Italiano Edit links This page was last edited on 18 February 2017, at 08 : 16. 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Question: where are the group of cells that control the natural resting heart rate found
Answer: sinoatrial node