Lactase persistence - wikipedia Lactase persistence Lactase persistence is the continued activity of the lactase enzyme in adulthood. Since lactase 's only function is the digestion of lactose in milk, in most mammal species, the activity of the enzyme is dramatically reduced after weaning. In some human populations, though, lactase persistence has recently evolved as an adaptation to the consumption of nonhuman milk and dairy products beyond infancy. The majority of people around the world remain lactase nonpersistent, and consequently are affected by varying degrees of lactose intolerance as adults. However, not all genetically lactase nonpersistent individuals are noticeably lactose intolerant, and not all lactose intolerant individuals have the lactase nonpersistence genotype. Contents 1 Global spread of the lactase persistence phenotype 2 Genetics 3 Evolutionary advantages 3.1 Gene - culture coevolution hypothesis 3.2 Benefits of being lactase persistent in adulthood 3.3 Calcium absorption hypothesis 3.4 Arid climate hypothesis 3.5 Lactase persistence and malaria resistance 4 Evolutionary history 4.1 Europe 4.2 Central Asia 4.3 Africa 5 In nonhumans 6 Confounding factors 7 References 8 External links Global spread of the lactase persistence phenotype Percentage of adults that can digest lactose in the indigenous population of the Old World The distribution of the lactase persistence phenotype, or the ability to digest lactose into adulthood, is not homogeneous in the world. Lactase persistence - frequencies are highly variable. In Europe, the distribution of the lactase persistence phenotype is clinal, with frequencies ranging from 15 -- 54 % in the south - east to 89 -- 96 % in the north - west. For example, only 17 % of Greeks and 14 % of Sardinians are predicted to possess this phenotype, while around 80 % of Finns and Hungarians and 100 % of Irish people are predicted to be lactase persistent. High frequencies of lactase persistence are also found in some places in Sub-Saharan Africa and in the Middle East. But the most common situation is intermediate to low lactase persistence : intermediate ( 11 to 32 % ) in Central Asia, low ( < = 5 % ) in Native Americans, East Asians, most Chinese populations and some African populations. In Africa, the distribution of lactase persistence is `` patchy '' : high variations of frequency are observed in neighbouring populations, for example between Beja and Nilotes from Sudan. This make the study of lactase persistence distribution more difficult. High percentages of lactase persistence phenotype are found in traditionally pastoralist populations like Fulani and Bedouins. It is absent in the Bantu of South Africa. Genetics Percentage of adults with a known lactase persistence genotype in the indigenous population of the Old World Multiple studies indicate that the presence of the two phenotypes `` lactase persistent '' ( derived phenotype ) and `` lactase nonpersistent ( hypolactasia ) '' is genetically programmed, and that lactase persistence is not necessarily conditioned by the consumption of lactose after the suckling period. The lactase persistent phenotype involves high mRNA expression, high lactase activity, and thus the ability to digest lactose, while the lactase nonpersistent phenotype involves low mRNA expression and low lactase activity. The enzyme lactase is encoded by the gene LCT. Hypolactasia is known to be recessively and autosomally inherited, which means that individuals with the nonpersistent phenotype are homozygous and received the two copies of a low lactase - activity allele ( the ancestral allele ) from their parents, who may be homozygous or at least heterozygous for the allele. Only one high - activity allele is required to be lactase persistent. Lactase persistence behaves as a dominant trait because half levels of lactase activity are sufficient to show significant digestion of lactose. Cis - acting transcriptional silence of the lactase gene is responsible for the hypolactasia phenotype. Furthermore, studies show that only eight cases were found where the parents of a child with lactase persistence were both hypolactasic. While a variety of genetic, as well as nutritional, factors determine lactase expression, no evidence has been found for adaptive alteration of lactase expression within an individual in response to changes in lactose consumption levels. The two distinct phenotypes of hypolactasia are : Phenotype I, characterized by reduced synthesis of precursor LPH, and phenotype II, associated with ample precursor synthesis, but reduced conversion of the protein to its mature molecular form. The lactase enzyme has two active sites which break down lactose. The first is at Glu1273 and the second is at Glu1749, which separately break down lactose into two separate kinds of molecules. At least six mutations ( single - nucleotide polymorphisms -- SNPs ) have been associated with lactase expression. They are all located in a region of the gene MCM6 upstream of LCT. This region is considered as an enhancer region for the transcription of LCT. The first identified genetic variant associated with lactase persistence is C / T * − 13910. The ancestral allele is C and the derived allele -- associated with lactase persistence -- is T. In the same study, another variant was found to also correlate with the phenotype in most of the cases : G * / A-22018. Other alleles associated with lactase persistence have been identified : G / C * - 14010, C / G * - 13907, and T / G * - 13915. This variant is described as part of a compound allele with T / C * 3712 in. These three variants are widespread in some populations. Rare variants were reported in a few studies, like the G / A * 14107 in the Xhosa and the Fulani ( from Mali ) ; the C / T * 13906 in the Fulani ( from Mali ). Lactase - persistence alleles vary in their geographic distributions. Within European and populations of European ancestry, they are almost entirely correlated with the presence of the − 13,910 C / T mutation in the enhancer region of the lactase gene ( LCT ). This differs from lactase persistence allelic distributions in the rest of the world, particularly in Africa and in the Middle East, where several alleles coexist. The T / G * - 13915 allele is found mostly in populations from East and North Africa and the Middle East. The allele G / C * - 14010 was identified in East Africa. The C / G * 13907 allele was described in Sudan and Ethiopia. The `` European '' allele T * 13910 allele is also found in some populations from Africa, including the Fulani ( from Mali, Sudan, and Cameroon ) and the Khoe from South Africa. This allele has also been found in Central Asia. It is not known how exactly the different variants described above regulate LCT expression. None of the mutations so far identified have been shown to be exclusively causal for lactase persistence, and it is possible that there are more alleles to be discovered. If we focus on the `` European variant '', the position − 13910 has an enhancer function on the lactase promoter ( the promoter facilitates the transcription of the LCT gene ). T − 13910 is a greater enhancer than C − 13910, so this mutation is thought to be responsible for the differences in lactase expression, although not enough evidence is found to prove that lactase persistence is only caused by C − 13910 → T − 13910. In addition, it was shown in one study involving a Finnish population that the lactase gene has a higher expression when G − 22018 is combined with T - 13910. Evolutionary advantages Lactase persistence is a text - book example of natural selection in humans : it has been reported to present stronger selection pressure than any other known human gene. Different methods are used to detect natural selection. For example, a 2007 study plotted extensive linkage disequilibrium of ancestral and current alleles. The score did in fact reflect positive selection of the C * - 14010 variant. Several pieces of evidence for positive selection acting at the T * - 13910 allele were given : it is located in a stretch of homozygosity of ca. 1Mb ; the strength of selection is similar to that estimated for the resistance to malaria. Haplotype inferences were performed on data from Central Asia populations ; selection was detected there as well -- though less strong than in European populations. Thus, even if T * 13910 may not be causative for lactase persistence, it was selected during human evolutionary history. The other variants were also proved to be under selection. The C * - 14010 allele is located on a particularly long stretch of homozygosity ( > 2 Mb ). Analysis of lactase persistence found among Maasai observed that the selection acting at C * - 14010 is even stronger than the selection on T * - 13910. The compound allele G * - 13915 & C * - 3712 was proved to be located on a long stretch of homozygosity ( 1.1 Mb to 1.3 Mb ). The ability to digest lactose is not an evolutionary novelty in human populations. Nearly all mammals begin life with the ability to digest lactose. This trait is advantageous during the infant stage, because milk serves as the primary source for nutrition. As weaning occurs, and other foods enter the diet, milk is no longer consumed. As a result, the ability to digest lactose no longer provides a distinct fitness advantage. This is evident in examining the mammalian lactase gene ( LCT ), which expression decreases after the weaning stage, resulting in a lowered production of lactase enzymes. When these enzymes are produced in low quantities, lactose non-persistence ( LNP ) results. The ability to digest fresh milk through adulthood is genetically coded for by different variants which are located upstream of the LCT gene and which differ among populations. Those variants are found at very high frequencies in some populations and show signatures of selection. Several hypotheses have been proposed to explain why the lactase persistence phenotype has been positively selected. Gene - culture coevolution hypothesis The gene -- culture coevolution hypothesis of the positive selection of the lactase persistence phenotype is based on the observation that pastoralist populations often present high levels of lactase persistence. According to this hypothesis, the reason of selection is the nutritional advantage of being lactase persistent. Individuals who expressed lactase - persistent phenotypes would have had a significant advantage in nutritional acquisition. This is especially true for societies in which the domestication of milk - producing animals and pastoralism became a main way of life. The combination of pastoralism and lactase persistence genes would have allowed individuals the advantage of niche construction, meaning they would have had less competition for resources by deriving a secondary food source, milk. Milk as a nutrition source may have been more advantageous than meat, as its rate of renewal is significantly faster. Rather than having to raise and slaughter animals, one cow or goat could repeatedly serve as a resource with fewer time and energy constraints. The competitive advantage conferred on lactose - tolerant individuals would have given rise to strong selective pressures for this genotype, especially in times of starvation and famine, which in turn gave rise to higher frequencies in lactase persistence within the populations. By contrast, for societies which did not engage in pastoral behaviors, no selective advantage exists for lactase persistence. Mutations which may have developed allelic variations which code for lactase production into adulthood are simply neutral mutations. They seemingly confer no fitness benefit to individuals. As a result, no selection has perpetuated the spread of these allelic variants, and the lactase persistence genotype and phenotype remains rare. For example, in East Asia, historical sources also attest that the Chinese did not consume milk, whereas the nomads who lived on the borders did. This reflects modern distributions of intolerance. China is particularly notable as a place of poor tolerance, whereas in Mongolia and the Asian steppes, milk and dairy products are a main nutrition source. The nomads also make an alcoholic beverage, called airag or kumis, from mare 's milk, although the fermentation process reduces the amount of lactose present. Two scenarios have been proposed for the gene - culture coevolution hypothesis : either lactase persistence developed and was selected after the onset of pastoralist practices ( culture - historical hypothesis ) ; or pastoralism spread only in populations where lactase persistence was already at high frequencies ( reverse - cause hypothesis ). There are exceptions to the hypothesis like the hunter - gatherers Hadza ( Tanzania ) with a prevalence of lactase persistence - phenotype of 50 %. Benefits of being lactase persistent in adulthood The consumption of lactose has been shown to benefit humans with lactase persistence through adulthood. For example, the 2009 British Women 's Heart and Health Study investigated the effects on women 's health of the alleles that coded for lactase persistence. Where the C allele indicated lactase nonpersistence and the T allele indicated lactase persistence, the study found that women who were homozygous for the C allele exhibited worse health than women with a C and a T allele and women with two T alleles. Women who were CC reported more hip and wrist fractures, more osteoporosis, and more cataracts than the other groups. They also were on average 4 -- 6 mm shorter than the other women, as well as slightly lighter in weight. In addition, factors such as metabolic traits, socioeconomic status, lifestyle, and fertility were found to be unrelated to the findings, thus it can be concluded that the lactase persistence benefited the health of these women who consumed dairy products and exhibited lactase persistence. Calcium absorption hypothesis Another possibility is the calcium absorption hypothesis. Lactose favors the intestinal absorption of calcium : it helps maintaining it in a soluble form. This can be advantageous in regions of low sunlight exposure where Vitamin D, necessary for the transport of calcium, is a limiting factor. Indeed, the UVB are a source of Vitamin D. Increased calcium absorption helps to prevent rickets and osteomalacia. Arid climate hypothesis A hypothesis specific to arid climate was proposed : here, milk is not only a source of nutrients, but also a source of fluid, which could be particularly advantageous during epidemics of gastrointestinal diseases like cholera ( where water is contaminated ). Lactase persistence and malaria resistance One study suggested that lactase persistence was selected for parallel to malaria resistance in the Fulani from Mali. Proposed mechanisms are : nutritional advantage of milk ; low content of p - aminobenzoic acid compared to non-milk diets ; intake of immunmodulators contained in milk. Evolutionary history According to the gene - culture coevolution hypothesis, the ability to digest lactose into adulthood ( lactase persistence ) became advantageous to humans after the invention of animal husbandry and the domestication of animal species that could provide a consistent source of milk. Hunter - gatherer populations before the Neolithic revolution were overwhelmingly lactose intolerant, as are modern hunter - gatherers. Genetic studies suggest that the oldest mutations associated with lactase persistence only reached appreciable levels in human populations in the last 10,000 years. This correlates with the beginning of animal domestication, which occurred during the Neolithic transition. Therefore, lactase persistence is often cited as an example of both recent human evolution and, as lactase persistence is a genetic trait but animal husbandry a cultural trait, gene - culture coevolution in the mutual human - animal symbiosis initiated with the advent of agriculture. Depending on the populations, one or the other hypothesis for the selective advantage of lactase persistence is more relevant : In Northern Europe, the calcium absorption hypothesis might be one of the factors leading to the strong selection coefficients, whereas in African populations, where vitamin D deficiency is not as much of an issue, the spread of the allele is most closely correlated with the added calories and nutrition from pastoralism. Several genetic markers for lactase persistence have been identified, and these show that lactase persistence has multiple origins in different parts of the world ( i.e. it is an example of convergent evolution ). In particular, it has been hypothesized that the T * 13910 variant appeared at least twice independently. Indeed, it is observed on two different haplotypes : H98, the more common ( among others in the Finnish and in the Fulani ) ; and H8 H12, related to geographically restricted populations. The common version is relatively older. The H98 variant - most common among Europeans - is estimated to have risen to significant frequencies about 7,500 years ago in the central Balkans and Central Europe, a place and time roughly corresponding to the archaeological Linearbandkeramik and Starčevo cultures. The T * 13910 variant is also found in North Africans. Thus it probably originated earlier than 7500 ya, in the Near East, but the earliest farmers did not have high levels of lactase persistence and did not consume significant amounts of unprocessed milk. Some hypotheses regarding the evolutionary history of lactase persistence in given regions of the world are described below. Europe Concerning Europe, the model proposed for the spread of lactase persistence combines selection and demographic processes. Some studies used modelling approaches to investigate the role of genetic drift ( reviewed in ). According to some models, the spread of lactase persistence in Europe can be attributed primarily to a form of genetic drift. Evidence can also come from other fields, for example written historical records : Roman authors recorded that the people of northern Europe, particularly Britain and Germany, drank unprocessed milk. This corresponds very closely with modern European distributions of lactose intolerance, where the people of Britain, Germany, and Scandinavia have a high tolerance, and those of southern Europe, especially Italy, have a lower tolerance. Central Asia In Central Asia, the causal polymorphism for lactase persistence is the same as in Europe ( T * 13910, rs4988235 ), suggesting genetic diffusion between the two geographical regions. It is indicated that the allele responsible for lactose persistence ( T * 13910 ) may have arisen in Central Asia, based on the higher frequency of lactase persistence among Kazakhs who have the lowest proportion of `` western '' gene pool inferred from admixture analysis from autosomal microsatellite data. This, in turn, could also be an indirect genetic proof of early domestication of horses for milk products as recently attested from archaeological remains. In Kazakhs, traditionally herders, lactose persistence frequency is estimated to 25 -- 32 %, of which only 40.2 % have symptoms and 85 -- 92 % of the individuals are carriers of the T * 13910 allele. Africa The situation is more complex in Africa, where all five main lactase persistence variants are found. The presence of T * 13910 alleles among populations inhabiting the continent is ascribed to gene flow from Europe. It has been hypothesized that the G * 13915 variant dispersed from the Middle East, in association with the domestication of the Arabian camel. The G - 14009 mutation is based in Ethiopia. The G * 13907 variant is concentrated among Afroasiatic speakers in Northeast Africa. The C * 14010 allele is today most common among pastoralist groups inhabiting eastern Africa, from where it is thought to have spread along with pastoralism into parts of southern Africa. It is also found at high frequencies among Tuscans. Ultimately, the C * 14010 lactase persistence variant is believed to have arrived from the Sahara in areas that were previously inhabited by Afroasiatic - speaking populations. This was deduced from the existence of animal husbandry - and milking - related loanwords of Afroasiatic origin in various Nilo - Saharan and Niger - Congo languages, as well as from the earliest appearance of processed milk lipids on ceramics which were found at the Tadrart Acacus archaeological site in Libya ( radiocarbon - dated to ~ 7,500 BP, close to the estimated age of the C * 14010 mutation ). The evolutionary processes driving the rapid spread of lactase persistence in some populations are not known. Among some populations inhabiting East Africa, lactase persistence has gone from negligible to near - ubiquitous frequencies in just 3000 years, suggesting a very strong selective pressure. Some studies also proposed that selection for lactase persistence is not as strong as supposed ( soft selective sweep ), and that its strength varies a lot depending on particular environmental conditions. In nonhumans Lactose malabsorption is typical for adult mammals, and lactase persistence is a phenomenon likely linked to human interactions in the form of dairying. Most mammals lose the ability to digest lactose once they are old enough to find their own source of nourishment away from their mothers. After weaning, or the transition from being milk - fed to consuming other types of food, their ability to produce lactase naturally diminishes as it is no longer needed. For example, in the time a piglet aged from five to 18 days, it lost 67 % of its lactose absorption ability. While nearly all humans can normally digest lactose for the first 5 to 7 years of their lives, most mammals stop producing lactase much earlier. Cattle can be weaned from their mothers ' milk at 6 months to a year of age. Lambs are regularly weaned around 16 weeks old. Such examples suggest that lactase persistence is a uniquely human phenomenon. 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External links Global lactase persistence genotype frequencies Global lactase persistence phenotype frequencies Retrieved from `` https://en.wikipedia.org/w/index.php?title=Lactase_persistence&oldid=824641892 '' Categories : Digestive system Talk Contents About Wikipedia Italiano 日本 語 Edit links This page was last edited on 8 February 2018, at 16 : 24. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: when do most mammals lose their ability to produce lactase
Answer: after weaning