Phantom limb - wikipedia Phantom limb For other uses, see Phantom limb ( disambiguation ). Phantom limb Play media A cat attempting to use its left foreleg to scoop litter several months after it has been amputated Specialty Neurology A phantom limb is the sensation that an amputated or missing limb is still attached. Approximately 60 to 80 % of individuals with an amputation experience phantom sensations in their amputated limb, and the majority of the sensations are painful. Phantom sensations may also occur after the removal of body parts other than the limbs, e.g. after amputation of the breast, extraction of a tooth ( phantom tooth pain ) or removal of an eye ( phantom eye syndrome ). Contents 1 Signs and symptoms 2 Mechanism 3 Treatment 3.1 Mirror box 4 Recent research 5 See also 6 References 7 Further reading 8 External links Signs and symptoms Although not all phantom limbs are painful, people will sometimes feel as if they are gesturing, feel itches, twitch, or even try to pick things up. The missing limb often feels shorter and may feel as if it is in a distorted and painful position. Occasionally, the pain can be made worse by stress, anxiety and weather changes. Phantom limb pain is usually intermittent. The frequency and intensity of attacks usually declines with time. Some people who have undergone gender reassignment surgery have reported the sensation of phantom genitals. The reports were less common among post-operative transgender women, but did occur in transgender men. Similarly, subjects who had undergone mastectomy reported experiencing phantom breasts ; these reports were substantially less common among post-operative transgender men, but did occur in transgender women. Mechanism This section possibly contains original research. Please improve it by verifying the claims made and adding inline citations. Statements consisting only of original research should be removed. ( January 2018 ) Phantom limb pain ( PLP ) is a complex phenomenon that includes a wide variety of symptoms ranging from tingling and itching to burning and aching. Until recently, the dominant hypothesis for the cause of phantom limbs was irritation in the severed nerve endings ( called `` neuromas '' ). When a limb is amputated, many severed nerve endings are terminated at the residual limb. These nerve endings can become inflamed, and were thought to send anomalous signals to the brain. These signals, being functionally nonsense, were thought to be interpreted by the brain as pain. Treatments based on this hypothesis were generally failures. In extreme cases, surgeons would perform a second amputation, shortening the stump, with the hope of removing the inflamed nerve endings and causing temporary relief from the phantom pain. But instead, the patients ' phantom pains increased, and many were left with the sensation of both the original phantom limb, as well as a new phantom stump, with a pain all its own. In some cases, surgeons even cut the sensory nerves leading into the spinal cord or in extreme cases, even removed the part of the thalamus that receives sensory signals from the body. By the late 1980s, Ronald Melzack had recognized that the peripheral neuroma account could not be correct. In his 1989 paper, `` Phantom Limbs, The Self And The Brain '' Melzack proposed the hypothesis of the `` neuromatrix. '' According to Melzack the experience of the body is created by a wide network of interconnecting neural structures. In 1991, Tim Pons and colleagues at the National Institutes of Health ( NIH ) showed that the primary somatosensory cortex in macaque monkeys undergoes substantial reorganization after the loss of sensory input. Vilayanur S. Ramachandran hypothesized that phantom limb sensations in humans could be due to reorganization in the somatosensory cortex, which is located in the postcentral gyrus, and which receives input from the limbs and body. Ramachandran and colleagues illustrated this hypothesis by showing that stroking different parts of the face led to perceptions of being touched on different parts of the missing limb. Ramachandran argued that the perception of being touched in different parts of the phantom limb was the perceptual correlate of cortical reorganization in the brain. However, research published in 1995 by Flor et al. demonstrated that pain ( rather than referred sensations ) was the perceptual correlate of cortical reorganization. In 1996 Knecht et al. published an analysis of Ramachandran 's hypothesis that concluded that there was no topographic relationship between referred sensations and cortical reorganization in the primary cortical areas. Recent research by Flor et al. suggests that non-painful referred sensations are correlated with a wide neural network outside the primary cortical areas. Not all scientists support the hypothesis that phantom limb pain is the result of maladaptive changes in the cortex. Pain researchers such as Tamar Makin ( Oxford ) and Marshall Devor ( Hebrew University, Jerusalem ) argue that phantom limb pain is primarily the result of `` junk '' inputs from the peripheral nervous system. Despite a great deal of research on the underlying neural mechanisms of phantom limb pain there is still no clear consensus as to its cause. Peripheral mechanisms ( areas of the nervous system outside the brain ) and central neural mechanisms ( inside the cortex ) are among the hypotheses that have gained the most support over recent years. However, none of these theoretical constructs appears to be able to explain the phenomenon of phantom limb pain independently and many experts believe that multiple mechanisms are likely responsible. Treatment Most approaches to treatment over the past two decades have not shown consistent symptom improvement. Treatment approaches have included medication such as antidepressants, spinal cord stimulation, vibration therapy, acupuncture, hypnosis, and biofeedback. Reliable evidence is lacking on whether any treatment is more effective than the others. Most treatments are not very effective. Ketamine or morphine may be useful around the time of surgery. Morphine may be helpful for longer periods of time. Evidence for gabapentin is mixed. Perineural catheters that provide local anesthetic agents have poor evidence of success when placed after surgery in an effort to prevent phantom limb pain. Mirror box One approach that has received public interest is the use of a mirror box. The mirror box provides a reflection of the intact hand or limb that allows the patient to `` move '' the phantom limb, and to unclench it from potentially painful positions. As of 2011, however, the quality of evidence is low. There is a wide range in the effectiveness of this approach. The potential for a person to benefit from mirror therapy is not predictable and appears to be related to the subjective ability of the patient to internalize the reflection of a complete limb as their own limb. About 40 % of people do not benefit from mirror therapy. Recent research In 2009 Lorimer Moseley and Peter Brugger carried out an experiment in which they encouraged seven arm amputees to use visual imagery to contort their phantom limbs into impossible configurations. Four of the seven subjects succeeded in performing impossible movements of the phantom limb. This experiment suggests that the subjects had modified the neural representation of their phantom limbs and generated the motor commands needed to execute impossible movements in the absence of feedback from the body. The authors stated that : `` In fact, this finding extends our understanding of the brain 's plasticity because it is evidence that profound changes in the mental representation of the body can be induced purely by internal brain mechanisms -- the brain truly does change itself. '' In 2012 V.S. Ramachandran and Paul McGeoch reported the case of a 57 - year - old woman ( known as R.N. ) who was born with a deformed right hand consisting of only three fingers and a rudimentary thumb. After a car crash at the age of 18, the woman 's deformed hand was amputated, which gave rise to feelings of a phantom hand. The phantom hand was experienced, however, as having all five fingers ( although some of the digits were foreshortened ). 35 years after her accident, the woman was referred for treatment after her phantom hand had become unbearably painful. McGeoch and Ramachandran trained R.N. using mirror box visual feedback, for 30 minutes a day, in which the reflection of her healthy left - hand was seen as superimposed onto where she felt her phantom right hand to be. After two weeks she was able to move her phantom fingers and was relieved of pain. Crucially, she also experienced that all five of her phantom fingers were now normal length. Ramachandran and McGeoch stated that this case provides evidence that the brain has an innate ( hard - wired ) template of a fully formed hand. In 2012 an experiment was conducted in which it was demonstrated that the movement of phantom limbs are `` real '' movements that involve the execution of a motor command. Amputees can also carry out imaginary movements of their phantom limbs ; however, these movements do not lead to a feeling that the phantom limb has changed position. This research indicates that clinicians using motor training for pain relief need to distinguish between imagined movements and real movements of phantom limbs. In 2013, experiments involving eight subjects were reported by Nadia Bolognini ( University of Milano - Bicocca ) in which transcranial direct current stimulation ( tDCS ) was used to temporarily reduce phantom limb pain. The researchers found that this type of stimulation could produce short - term ( under 90 minutes ) reduction of pain without affecting other amputation - related phenomena. In 2013 research conducted by Tamar Makin ( Oxford University ) indicated that after amputation the area of the cortex that received information from an amputated hand may be taken over by the remaining hand. Her research suggests that the extent of this transition is determined by the extent to which the person uses the remaining hand to perform the functions of the missing hand. See also Phantom eye syndrome Neuropathic pain Synesthesia Supernumerary phantom limb, where sensations are felt in a limb that never existed Visual release hallucinations References Jump up ^ Melzack, R. ( 1992 ). `` Phantom limbs ''. Scientific American ( 266 ) : 120 -- 126. ^ Jump up to : Ramchandran, VS ; Hirstein, William ( 1998 ). `` The perception of phantom limbs '' ( PDF ). Brain. 121 ( 9 ) : 1603 -- 1630. doi : 10.1093 / brain / 121.9. 1603. PMID 9762952. Jump up ^ Sherman, R.A., Sherman, C.J. & Parker, L. ( 1984 ). `` Chronic phantom and stump pain among American veterans : Results of a survey ''. Pain. 18 : 83 -- 95. doi : 10.1016 / 0304 - 3959 ( 84 ) 90128 - 3. CS1 maint : Multiple names : authors list ( link ) Jump up ^ Ahmed, A. ; Bhatnagar, S. ; Rana, S.P. ; Ahmad, S.M. ; Joshi, S. ; Mishra, S. ( 2014 ). `` Prevalence of phantom breast pain and sensation among postmastectomy patients suffering from breast cancer : a prospective study ''. Pain Pract. 14 ( 2 ) : E17 -- 28. doi : 10.1111 / papr. 12089. PMID 23789788. Retrieved 10 June 2015. Jump up ^ Marbach, J.J. ; Raphael, K.G. ( 2000 ). `` Phantom tooth pain : a new look at an old dilemma ''. Pain Med. 1 ( 1 ) : 68 -- 77. doi : 10.1046 / j. 1526 - 4637.2000. 00012. x. PMID 15101965. Retrieved 10 June 2015. Jump up ^ Sörös, P. ; Vo, O. ; Husstedt, I. - W. ; Evers, S. ; Gerding, H. ( 2003 ). `` Phantom eye syndrome : Its prevalence, phenomenology, and putative mechanisms ''. Neurology. 60 ( 9 ) : 1542 -- 1543. doi : 10.1212 / 01. wnl. 0000059547.68899. f5. PMID 12743251. Retrieved 10 June 2015. Jump up ^ Andreotti, A.M. ; Goiato, M.C. ; Pellizzer, E.P. ; Pesqueira, A.A. ; Guiotti, A.M. ; Gennari - Filho, H. ; dos Santos, D.M. ( 2014 ). `` Phantom eye syndrome : A review of the literature ''. ScientificWorldJournal. 2014 : 686493. doi : 10.1155 / 2014 / 686493. PMC 4273592. PMID 25548790. Retrieved 10 June 2015. Jump up ^ Nikolajsen, L. ; Jensen, T.S. ( 2006 ). McMahon S, Koltzenburg M, eds. Wall & Melzack 's Textbook of Pain ( 5th ed. ). Elsevier. pp. 961 -- 971. CS1 maint : Uses editors parameter ( link ) Jump up ^ Occurrence of phantom genitalia after gender reassignment surgery, in Medical Hypotheses ( 2007 ), 69, 1001 -- 1003 ( archived at the University of San Diego ), by V.S. Ramachandran and Paul D. McGeoch ; published February 16, 2007 ; doi : 10.1016 / j. mehy. 2007.02. 024 Jump up ^ Phantom Penises In Transsexuals, by V.S. Ramachandran ; in Journal of Consciousness Studies Volume 15, Number 1, 2008, pp. 5 - 16 ( 12 ) ; retrieved July 30, 2016 Jump up ^ Phantom limb pain, Wellcome Trust Web site article on Pain by Jonathan Cole `` Archived copy ''. Archived from the original on 2008 - 09 - 12. Retrieved 2008 - 09 - 23. CS1 maint : Archived copy as title ( link ) Jump up ^ Subedi B, Grossberg GT ( 2011 ). `` Phantom limb pain : mechanisms and treatment approaches ''. Pain Research and Treatment. 2011 : 864605. doi : 10.1155 / 2011 / 864605. PMC 3198614. PMID 22110933. Jump up ^ Canadian Psychology, 1989, 30 : 1 Jump up ^ Pons TP, Garraghty PE, Ommaya AK, Kaas JH, Taub E, Mishkin M ( 1991 ). `` Massive cortical reorganization after sensory deafferentation in adult macaques ''. Science. 252 ( 5014 ) : 1857 -- 1860. doi : 10.1126 / science. 1843843. PMID 1843843. Jump up ^ Ramachandran, V.S., Rogers - Ramachandran, D.C. & Stewart, M. ( 1992 ). `` Perceptual correlates of massive cortical reorganization '' ( PDF ). Science. 258 ( 5085 ) : 1159 -- 1160. doi : 10.1126 / science. 1439826. PMID 1439826. CS1 maint : Multiple names : authors list ( link ) Jump up ^ Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N, Phantom - limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 1995 ; 375 : 482 -- 484. Jump up ^ Knecht, S, Henningsen, H, Elbert, T, Flor, H, Hohling, C, Pantev, C, Taub, E, Reorganizational and perceptional changes after amputation, Brain, 1996, 119, 1213 - 1219 ( 1 ) Jump up ^ Handbook of Neuropsychology : Plasticity and rehabilitation, Jordan Grafman, Chapter 9, page 187 Jump up ^ Epoch Times website, July 16, 2014 Jump up ^ Peripheral nervous system origin of phantom limb pain, Pain, Vol. 155, Issue 7, pages 1384 - 1391 ( 2 ) Jump up ^ Phantom limb pain : a review of the literature on attributes and potential mechanisms, Journal of Pain and Symptom Management, 17 ( 2 ) : 125 - 42, March 1999 ( 3 ) Jump up ^ Phantom Limb Pain : Mechanisms and Treatment Approaches, Subedi B., Grossberg G., Pain Res Treat. 2011 ; 2011 : 864605, doi : 10.1155 / 2011 / 864605 ( 4 ) Jump up ^ Foell, Jens ; Bekrater - Bodmann, Robin ; Flor, Herta ; Cole, Jonathan ( December 2011 ). `` Phantom Limb Pain After Lower Limb Trauma : Origins and Treatments ''. International Journal of Lower Extremity Wounds. 10 : 224 -- 235. doi : 10.1177 / 1534734611428730. Jump up ^ Alviar, Maria Jenelyn M. ; Hale, Tom ; Dungca, Monalisa ( 2016 - 10 - 14 ). `` Pharmacologic interventions for treating phantom limb pain ''. The Cochrane Database of Systematic Reviews. 10 : CD006380. doi : 10.1002 / 14651858. CD006380. pub3. ISSN 1469 - 493X. PMID 27737513. Jump up ^ Flor, H ; Nikolajsen, L ; Jensn, T ( November 2006 ). `` Phantom limb pain : a case of maladaptive CNS plasticity ? '' ( PDF ). Nature Reviews Neuroscience. 7 : 873 -- 881. doi : 10.1038 / nrn1991. PMID 17053811. ^ Jump up to : McCormick, Z ; Chang - Chien, G ; Marshall, B ; Huang, M ; Harden, RN ( February 2014 ). `` Phantom limb pain : a systematic neuroanatomical - based review of pharmacologic treatment ''. Pain Medicine. 15 ( 2 ) : 292 -- 305. doi : 10.1111 / pme. 12283. PMID 24224475. Jump up ^ Bosanquet, DC. ; Glasbey, JC. ; Stimpson, A. ; Williams, IM. ; Twine, CP. ( Jun 2015 ). `` Systematic Review and Meta - analysis of the Efficacy of Perineural Local Anaesthetic Catheters after Major Lower Limb Amputation ''. Eur J Vasc Endovasc Surg. 50 : 241 -- 9. doi : 10.1016 / j. ejvs. 2015.04. 030. PMID 26067167. Jump up ^ Ramachandran, V.S., Rogers - Ramachandran, D.C., Cobb, S. ( 1995 ). `` Touching the phantom ''. Nature. 377 ( 6549 ) : 489 -- 490. doi : 10.1038 / 377489a0. PMID 7566144. CS1 maint : Multiple names : authors list ( link ) Jump up ^ Ramachandran, V.S., Rogers - Ramachandran, D.C. ( 1996 ). `` Synaesthesia in phantom limbs induced with mirrors '' ( PDF ). Proceedings of the Royal Society of London B. 263 ( 1369 ) : 377 -- 386. doi : 10.1098 / rspb. 1996.0058. PMID 8637922. CS1 maint : Multiple names : authors list ( link ) Jump up ^ Rothgangel, AS ; Braun, SM ; Beurskens, AJ ; Seitz, RJ ; Wade, DT ( March 2011 ). `` The clinical aspects of mirror therapy in rehabilitation : a systematic review of the literature ''. International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation. 34 ( 1 ) : 1 -- 13. doi : 10.1097 / MRR. 0b013e3283441e98. PMID 21326041. Jump up ^ Foell ; et al. ( 2013 ). `` Mirror Therapy for phantom limb pairn : Brain changes and the role of body representation ''. European Journal of Pain. 18 : 729 -- 739. doi : 10.1002 / j. 1532 - 2149.2013. 00433. x. Jump up ^ Moseley, Brugger, Interdependence of movement and anatomy persists when amputees learn a physiologically impossible movement of their phantom limb, PNAS, Sept 16, 2009, ( 5 ) Jump up ^ McGeoch, P., and Ramachandran, V., ( 2012 ), The appearance of new phantom fingers post-amputation in a phocomelus, Neurocase, 18 ( 2 ), 95 - 97. Jump up ^ The moving phantom. Motor execution or motor imagery ?, Lorimer Moseley, Body in Mind blog site, July 20, 2012 ( 6 ) Jump up ^ Bolognini N, Olgiati E, Maravita A, Ferraro F, Fregni F ( August 2013 ). `` Motor and parietal cortex stimulation for phantom limb pain and sensations ''. Pain. 154 ( 8 ) : 1274 -- 80. doi : 10.1016 / j. pain. 2013.03. 040. PMID 23707312. Jump up ^ Makin TR, Cramer AO, Scholz J, Hahamy A, Henderson Slater D, Tracey I, Johansen - Berg H ( 2013 ). `` Deprivation - related and use - dependent plasticity go hand in hand ''. eLife. 2 : e01273. doi : 10.7554 / eLife. 01273. PMC 3823186. PMID 24220510. Further reading Halligan, P.W. ; Zeman, A. ; Berger, A. ( 1999 ), `` Phantoms in the Brain '', British Medical Journal, 319 : 587 -- 588, doi : 10.1136 / bmj. 319.7210. 587, PMC 1116476, PMID 10473458 Halligan, P.W. ( 2002 ), `` Phantom limbs : The body in mind '', Cognitive Neuropsychiatry, 7 ( 3 ) : 251 -- 268, doi : 10.1080 / 13546800244000111, PMID 16571541 Murray, C. ( 2009 ), `` Amputation, Prosthesis Use, and Phantom Limb Pain '', Amputation, Prosthesis Use, and Phantom Limb Pain, Springer : 1 -- 5, doi : 10.1007 / 978 - 0 - 387 - 87462 - 3_1 Vilayanur S. Ramachandran, Brang David. `` Phantom touch ''. Scholarpedia. 4 ( 10 ) : 8244. doi : 10.4249 / scholarpedia. 8244. External links Classification ICD - 10 : G54. 6 - G54. 7 ICD - 9 - CM : 353.6 MeSH : D010591 DiseasesDB : 29431 Review article from the Science Creative Quarterly Retrieved from `` https://en.wikipedia.org/w/index.php?title=Phantom_limb&oldid=865406982 '' Categories : Neurological disorders Syndromes Amputations Hallucinations Hidden categories : CS1 maint : Multiple names : authors list CS1 maint : Uses editors parameter CS1 maint : Archived copy as title Infobox medical condition ( new ) Articles that may contain original research from January 2018 All articles that may contain original research Articles containing video clips Talk Contents About Wikipedia Čeština Dansk Deutsch Español فارسی Français 한국어 Հայերեն Italiano Magyar Nederlands 日本 語 Português Русский తెలుగు ไทย Türkçe 中文 10 more Edit links This page was last edited on 23 October 2018, at 19 : 17 ( UTC ). About Wikipedia

Question: what is it called when you lose a limb
Answer: amputation