Cytoskeleton - wikipedia Cytoskeleton Cell biology The animal cell Components of a typical animal cell : Nucleolus Nucleus Ribosome ( little dots ) Vesicle Rough endoplasmic reticulum Golgi apparatus ( or `` Golgi body '' ) Cytoskeleton Smooth endoplasmic reticulum Mitochondrion Vacuole Cytosol ( fluid that contains organelles, comprising the cytoplasm ) Lysosome Centrosome Cell membrane The eukaryotic cytoskeleton. Actin filaments are shown in red, and microtubules composed of beta tubulin are in green. A cytoskeleton is present in all cells of all domains of life ( archaea, bacteria, eukaryotes ). It is a complex network of interlinking filaments and tubules that extend throughout the cytoplasm, from the nucleus to the plasma membrane. The cytoskeletal systems of different organisms are composed of similar proteins. In eukaryotes, the cytoskeletal matrix is a dynamic structure composed of three main proteins, which are capable of rapid growth or disassembly dependent on the cell 's requirements at a certain period of time. The structure, function and dynamic behavior of the cytoskeleton can be very different, depending on organism and cell type. Even within one cell the cytoskeleton can change through association with other proteins and the previous history of the network. A multitude of functions can be performed by the cytoskeleton. Its primary function would arguably be to give the cell its shape and mechanical resistance to deformation, and through association with extracellular connective tissue and other cells it stabilizes entire tissues. The cytoskeleton can also contract, thereby deforming the cell and the cell 's environment and allowing cells to migrate. Moreover, it is involved in many cell signaling pathways : in the uptake of extracellular material ( endocytosis ), segregates chromosomes during cellular division, is involved in cytokinesis ( the division of a mother cell into two daughter cells ), provides a scaffold to organize the contents of the cell in space and for intracellular transport ( for example, the movement of vesicles and organelles within the cell ) ; and can be a template for the construction of a cell wall. Furthermore, it forms specialized structures, such as flagella, cilia, lamellipodia and podosomes. A large - scale example of an action performed by the cytoskeleton is muscle contraction. In the muscle, there are groups of highly specialized cells that work together to perform a function known as muscle contraction. A main component in the cytoskeleton that helps show the true function of this muscle contraction is known as a microfilament. Microfilaments are composed of the most abundant cellular protein known as actin. During contraction of a muscle, within each muscle cell, myosin molecular motors collectively exert forces on parallel actin filaments. Muscle contraction starts from nerve impulses which then causes increased amounts of calcium to be released from the sarcoplasmic reticulum. Increases in calcium in the cytosol allows muscle contraction to begin with the help of two proteins, tropomyosin and troponin. Tropomyosin inhibits the interaction between actin and myosin, while troponin senses the increase in calcium and releases the inhibition. This action contracts the muscle cell, and through the synchronous process in many muscle cells, the entire muscle. Contents 1 History 2 Eukaryotic cytoskeleton 2.1 Microfilaments ( actin filaments ) 2.2 Intermediate filaments 2.3 Microtubules 2.4 Comparison 2.5 Septins 2.6 Spectrin 2.7 Yeast cytoskeleton 3 Prokaryotic cytoskeleton 3.1 FtsZ 3.2 MreB and ParM 3.3 Crescentin 4 Common features and differences between prokaryotes and eukaryotes 5 Cytoplasmic Streaming 6 See also 7 References 8 External links History In 1903, Nikolai K. Koltsov proposed that the shape of cells was determined by a network of tubules that he termed the cytoskeleton. The concept of a protein mosaic that dynamically coordinated cytoplasmic biochemistry was proposed by Rudolph Peters in 1929 while the term ( cytosquelette, in French ) was first introduced by French embryologist Paul Wintrebert in 1931. When the cytoskeleton was first introduced, it was thought to be an uninteresting gel - like substance that helps organelles stay in place. Much research took place to try to understand the purpose of the cytoskeleton and its components. With the help of Stuart Hameroff and Roger Penrose, they discovered that microtubules vibrate within neurons in the brain which suggest that brain waves come from deeper microtubule vibrations. This discovery showed that the cytoskeleton is not just a gel like substance but it actually has a purpose. Initially, it was thought that the cytoskeleton was exclusive to eukaryotes but in 1992, it was discovered to be present in prokaryotes as well. This discovery came after the realization that bacteria possess proteins that are homologous to tubulin and actin ; the main components of the eukaryotic cytoskeleton. Eukaryotic cytoskeleton Actin cytoskeleton of mouse embryo fibroblasts, stained with phalloidin Eukaryotic cells contain three main kinds of cytoskeletal filaments : microfilaments, microtubules, and intermediate filaments. Each cytoskeletal filament type is formed by polymerization of a distinct type of protein subunit and has its own characteristic shape and intracellular distribution. Microfilaments are polymers of the protein actin and are 7 nm in diameter. Microtubules are composed of tubulin and are 25 nm in diameter. Intermediate filaments are composed of various proteins, depending on the type of cell in which they are found ; they are normally 8 - 12 nm in diameter. The cytoskeleton provides the cell with structure and shape, and by excluding macromolecules from some of the cytosol, it adds to the level of macromolecular crowding in this compartment. Cytoskeletal elements interact extensively and intimately with cellular membranes. Neurodegenerative disorders have recently become more understood in context to what parts of the cell they affect. Diseases, such as amyotrophic lateral sclerosis, Alzheimer 's Disease, Huntington 's disease, and Parkinson 's disease have had breakthrough research that supports the conclusion that neurodegenerative diseases affect the cytoskeleton. Parkinson 's disease is a condition that causes the degradation of neurons, resulting in tremors, rigidity, and other non-motor symptoms. Research has found evidence that microtubule assembly and stability in the cytoskeleton is compromised causing the neurons to degrade over time. Alzheimer 's disease is much like Parkinson 's in that it is also a neurodegenerative disease that affects the cytoskeleton. Tau proteins, which stabilize microtubules, malfunction in patient 's affected by Alzheimers, causing pathology with the cytoskeleton. Huntington 's disease has also been found to affect the cytoskeleton of cells by excess glutamine in the Huntington protein, which is involved with linking vesicles to the cytoskeleton. An error with this protein is proposed to be a factor in the development of the disease. A fourth neurodegenerative disorder is amyotrophic lateral sclerosis, or ALS, which causes a loss of movement by the degradation of motor neurons from defects of the cytoskeleton. A number of small - molecule cytoskeletal drugs have been discovered that interact with actin and microtubules. These compounds have proven useful in studying the cytoskeleton and several have clinical applications. All filaments interact with accessory proteins that regulate and link the filaments to other cell compounds and each other. The accessory proteins are essential for controlled assembly of cytoskeletal filaments in particular locations, and they include motor proteins. Microfilaments ( actin filaments ) Main article : microfilament Microfilaments are composed of linear polymers of G - actin proteins, and generate force when the growing ( plus ) end of the filament pushes against a barrier, such as the cell membrane. They also act as tracks for the movement of myosin molecules that affix to the microfilament and `` walk '' along them. In general, the major component or protein of microfilaments are actin. The G - actin monomer combines to form a polymer which continues to form the microfilament ( actin filament ). These subunits then assemble into two chains that intertwine into what is called, F - actin chains. Myosin motoring along F - actin filaments generates contractile forces in so - called actomyosin fibers, both in muscle as well as most non-muscle cell types. Actin structures are controlled by the Rho family of small GTP - binding proteins such as Rho itself for contractile acto - myosin filaments ( `` stress fibers '' ), Rac for lamellipodia and Cdc42 for filopodia. Functions include : Muscle contraction Cell movement Intracellular transport / trafficking Maintenance of eukaryotic cell shape Cytokinesis Cytoplasmic streaming Intermediate filaments Microscopy of keratin filaments inside cells Main article : intermediate filament Intermediate filaments are a part of the cytoskeleton of many eukaryotic cells. These filaments, averaging 10 nanometers in diameter, are more stable ( strongly bound ) than actin filaments, and heterogeneous constituents of the cytoskeleton. Like actin filaments, they function in the maintenance of cell - shape by bearing tension ( microtubules, by contrast, resist compression but can also bear tension during mitosis and during the positioning of the centrosome ). Intermediate filaments organize the internal tridimensional structure of the cell, anchoring organelles and serving as structural components of the nuclear lamina. They also participate in some cell - cell and cell - matrix junctions. Nuclear lamina exist in all animals and all tissues. Some animals like the fruit fly do not have any cytoplasmic intermediate filaments. In those animals that express cytoplasmic intermediate filaments, these are tissue specific. Keratin intermediate filaments in epithelial cells provide protection for different mechanical stresses the skin may endure. They also provide protection for organs against metabolic, oxidative, and chemical stresses. Strengthening of epithelial cells with these intermediate filaments may prevent onset of apoptosis, or cell death, by reducing the probability of stress. Intermediate filaments are most commonly known as the support system or `` scaffolding '' for the cell and nucleus while also playing a role in some cell functions. In combination with proteins and desmosomes, the intermediate filaments form cell - cell connections and anchor the cell - matrix junctions that are used in messaging between cells as well as vital functions of the cell. These connections allow the cell to communicate through the desmosome of multiple cells to adjust structures of the tissue based on signals from the cells environment. Mutations in the IF proteins have been shown to cause serious medical issues such as premature aging, desmin mutations compromising organs, Alexander Disease, and muscular dystrophy. Different intermediate filaments are : made of vimentins. Vimentin intermediate filaments are in general present in mesenchymal cells. made of keratin. Keratin is present in general in epithelial cells. neurofilaments of neural cells. made of lamin, giving structural support to the nuclear envelope. made of desmin, play an important role in structural and mechanical support of muscle cells. Microtubules Microtubules in a gel - fixated cell Main article : microtubule Microtubules are hollow cylinders about 23 nm in diameter ( lumen = approximately 15 nm in diameter ), most commonly comprising 13 protofilaments that, in turn, are polymers of alpha and beta tubulin. They have a very dynamic behavior, binding GTP for polymerization. They are commonly organized by the centrosome. In nine triplet sets ( star - shaped ), they form the centrioles, and in nine doublets oriented about two additional microtubules ( wheel - shaped ), they form cilia and flagella. The latter formation is commonly referred to as a `` 9 + 2 '' arrangement, wherein each doublet is connected to another by the protein dynein. As both flagella and cilia are structural components of the cell, and are maintained by microtubules, they can be considered part of the cytoskeleton. There are two types of cilia : motile and non-motile cilia. Cilia are short and more numerous than flagella. The motile cilia have a rhythmic waving or beating motion compared to the non-motile cilia which receive sensory information for the cell ; processing signals from the other cells or the fluids surrounding it. Additionally, the microtubules control the beating ( movement ) of the cilia and flagella. Also, the dynein arms attached to the microtubules function as the molecular motors. The motion of the cilia and flagella is created by the microtubules sliding past one another, which requires ATP. They play key roles in : intracellular transport ( associated with dyneins and kinesins, they transport organelles like mitochondria or vesicles ). Cross section diagram through the cilium shows the `` 9 + 2 '' arrangement of microtubules. the axoneme of cilia and flagella. the mitotic spindle. synthesis of the cell wall in plants. In addition to the roles described above, Stuart Hameroff and Roger Penrose have proposed that microtubules function in consciousness. Comparison Cytoskeleton type Diameter ( nm ) Structure Subunit examples Microfilaments 6 double helix actin Intermediate filaments 10 two anti-parallel helices / dimers, forming tetramers vimentin ( mesenchyme ) glial fibrillary acidic protein ( glial cells ) neurofilament proteins ( neuronal processes ) keratins ( epithelial cells ) nuclear lamins Microtubules 23 protofilaments, in turn consisting of tubulin subunits in complex with stathmin α - and β - tubulin Septins Main article : Septin Septins are a group of the highly conserved GTP binding proteins found in eukaryotes. Different septins form protein complexes with each other. These can assemble to filaments and rings. Therefore, septins can be considered part of the cytoskeleton. The function of septins in cells include serving as a localized attachment site for other proteins, and preventing the diffusion of certain molecules from one cell compartment to another. In yeast cells, they build scaffolding to provide structural support during cell division and compartmentalize parts of the cell. Recent research in human cells suggests that septins build cages around bacterial pathogens, immobilizing the harmful microbes and preventing them from invading other cells. Spectrin Main article : Spectrin Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane in eukaryotic cells. Spectrin forms pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. Yeast cytoskeleton See also : Yeast In budding yeast ( an important model organism ), actin forms cortical patches, actin cables, and a cytokinetic ring and the cap. Cortical patches are discrete actin bodies on the membrane and are vital for endocytosis, especially the recycling of glucan synthase which is important for cell wall synthesis. Actin cables are bundles of actin filaments and are involved in the transport of vesicles towards the cap ( which contains a number of different proteins to polarize cell growth ) and in the positioning of mitochondria. The cytokinetic ring forms and constricts around the site of cell division. Prokaryotic cytoskeleton Main article : Prokaryotic cytoskeleton Prior to the work of Jones et al., 2001, the cell wall was believed to be the deciding factor for many bacterial cell shapes, including rods and spirals. When studied, many misshapen bacteria were found to have mutations linked to development of a cell envelope. The cytoskeleton was once thought to be a feature only of eukaryotic cells, but homologues to all the major proteins of the eukaryotic cytoskeleton have been found in prokaryotes. Harold Erickson notes that before 1992, only eukaryotes were believed to have cytoskeleton components. However, research in the early ' 90s suggested that bacteria and archaea had homologues of actin and tubulin, and that these were the basis of eukaryotic microtubules and microfilaments. Although the evolutionary relationships are so distant that they are not obvious from protein sequence comparisons alone, the similarity of their three - dimensional structures and similar functions in maintaining cell shape and polarity provides strong evidence that the eukaryotic and prokaryotic cytoskeletons are truly homologous. Three laboratories independently discovered that FtsZ, a protein already known as a key player in bacterial cytokinesis, had the `` tubulin signature sequence '' present in all α -, β -, and γ - tubulins. However, some structures in the bacterial cytoskeleton may not have been identified as of yet. FtsZ FtsZ was the first protein of the prokaryotic cytoskeleton to be identified. Like tubulin, FtsZ forms filaments in the presence of guanosine triphosphate ( GTP ), but these filaments do not group into tubules. During cell division, FtsZ is the first protein to move to the division site, and is essential for recruiting other proteins that synthesize the new cell wall between the dividing cells. MreB and ParM Prokaryotic actin - like proteins, such as MreB, are involved in the maintenance of cell shape. All non-spherical bacteria have genes encoding actin - like proteins, and these proteins form a helical network beneath the cell membrane that guides the proteins involved in cell wall biosynthesis. Some plasmids encode a separate system that involves an actin - like protein ParM. Filaments of ParM exhibit dynamic instability, and may partition plasmid DNA into the dividing daughter cells by a mechanism analogous to that used by microtubules during eukaryotic mitosis. Crescentin The bacterium Caulobacter crescentus contains a third protein, crescentin, that is related to the intermediate filaments of eukaryotic cells. Crescentin is also involved in maintaining cell shape, such as helical and vibrioid forms of bacteria, but the mechanism by which it does this is currently unclear. Additionally, curvature could be described by the displacement of crescentic filaments, after the disruption of peptidoglycan synthesis. Common features and differences between prokaryotes and eukaryotes By definition, the cytoskeleton is composed of proteins that can form longitudinal arrays ( fibres ) in all organisms. These filament forming proteins have been classified into 4 classes. Tubulin - like, actin - like, Walker A cytoskeletal ATPases ( WACA - proteins ), and intermediate filaments. Tubulin - like proteins are tubulin in eukaryotes and FtsZ, TubZ, RepX in prokaryotes. Actin - like proteins are actin in eukaryotes and MreB, FtsA in prokaryotes. An example of a WACA - proteins, which are mostly found in prokaryotes, is MinD. Examples for intermediate filaments, which have almost exclusively been found in animals ( i.e. eukaryotes ) are the lamins, keratins, vimentin, neurofilaments, and desmin. Although tubulin - like proteins share some amino acid sequence similarity, their equivalence in protein-fold and the similarity in the GTP binding site is more striking. The same holds true for the actin - like proteins and their structure and ATP binding domain. Cytoskeletal proteins are usually correlated with cell shape, DNA segregation and cell division in prokaryotes and eukaryotes. Which proteins fulfill which task is very different. For example, DNA segregation in all eukaryotes happens through use of tubulin, but in prokaryotes either WACA proteins, actin - like or tubulin - like proteins can be used. Cell division is mediated in eukaryotes by actin, but in prokaryotes usually by tubulin - like ( often FtsZ - ring ) proteins and sometimes ( Crenarchaeota ) ESCRT - III, which in eukaryotes still has a role in the last step of division. Cytoplasmic streaming Cytoplasmic streaming, also known as cylcosis, is the active movement of a cell 's contents along the components of the cytoskeleton. While mainly seen in plants, all cell types use this process for transportation of waste, nutrients, and organelles to other parts of the cell. Plant and algae cells are generally larger than many other cells ; so cytoplasmic streaming is important in these types of cells. This is because the cell 's extra volume requires cytoplasmic streaming in order to move organelles throughout the entire cell. Organelles move along microfilaments in the cytoskeleton driven by myosin motors binding and pushing along actin filament bundles. See also Biology portal Molecular and cellular biology portal Cell ( biology ) Organelle Nuclear matrix Microfilament References ^ Jump up to : Hardin, Jeff ; Bertoni, Gregory ; Kleinsmith, Lewis J. ( 2015 ). Becker 's World of the Cell ( 8th ed. ). New York : Pearson. pp. 422 -- 446. ISBN 978013399939 - 6. Jump up ^ McKinley, Michael ; Dean O'Loughlin, Valerie ; Pennefather - O'Brien, Elizabeth ; Harris, Ronald ( 2015 ). Human Anatomy ( 4th ed. ). New York : McGraw Hill Education. p. 29. ISBN 0 - 07 - 352573 - 1. ^ Jump up to : Alberts, Bruce ; et al. ( 2008 ). 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Proceedings of the National Academy of Sciences of the United States of America. 110 ( 35 ) : 14132 -- 14137. doi : 10.1073 / pnas. 1302736110. ISSN 1091 - 6490. PMC 3761564. PMID 23940314. Jump up ^ Goldstein, Raymond E. ; Meent, Jan - Willem van de ( 2015 - 08 - 06 ). `` A physical perspective on cytoplasmic streaming ''. Interface Focus. 5 ( 4 ) : 20150030. doi : 10.1098 / rsfs. 2015.0030. ISSN 2042 - 8898. External links Wikimedia Commons has media related to Cytoskeleton. Cytoskeleton Monthly News and Blog MBInfo - Cytoskeleton Dynamics Cytoskeleton, Cell Motility and Motors - The Virtual Library of Biochemistry, Molecular Biology and Cell Biology Cytoskeleton database, clinical trials, recent literature, lab registry... Animation of leukocyte adhesion ( Animation with some images of actin and microtubule assembly and dynamics. ) http://cellix.imba.oeaw.ac.at/ Cytoskeleton and cell motility including videos Open access review article on the emergent complexity of the cytoskeleton ( appeared in Advances in Physics, 2013 ) Structures of the cell / organelles ( TH H1. 00.01. 2 - 3 ) Endomembrane system Cell membrane Nucleus Nucleolus Endoplasmic reticulum Golgi apparatus Parenthesome Autophagosome Vesicles Exosome Lysosome Endosome Phagosome Vacuole Acrosome Cytoplasmic granules Melanosome Microbody Glyoxysome Peroxisome Weibel -- Palade body Cytoskeleton Microfilaments Intermediate filaments Microtubules Prokaryotic cytoskeleton MTOCs Centrosome Centriole Basal body Spindle pole body Myofibril Endosymbionts Mitochondrion Plastids Chloroplast Chromoplast Gerontoplast Leucoplast Amyloplast Elaioplast Proteinoplast Tannosome Other internal RNA Ribosome Spliceosome Vault Cytoplasm Proteasome External Undulipodium Cilium Flagellum Axoneme Radial spoke Extracellular matrix Cell wall Proteins of the cytoskeleton Human Microfilaments and ABPs Myofilament Actins A1 A2 C1 G1 G2 Myosins MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H ) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1 Other Tropomodulin Troponin Tropomyosin Actinin Arp2 / 3 complex actin depolymerizing factors Cofilin Destrin Gelsolin Profilin Titin Other Wiskott - Aldrich syndrome protein Fibrillin Filamin FLNA FLNB FLNC Espin TRIOBP Intermediate filaments Type 1 / 2 ( Keratin, Cytokeratin ) Epithelial keratins ( soft alpha - keratins ) type I / chromosome 17 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II / chromosome 12 2A 5 6A 6B 7 8 9 Hair keratins ( hard alpha - keratins ) type I / chromosome 17 31 32 33A 33B 34 35 36 37 38 type II / chromosome 12 81 82 83 84 85 86 Ungrouped alpha chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80 Not alpha Beta - keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins : A / C B1 B2 Microtubules and MAPs Kinesins KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3 Dyneins axonemal : DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic : DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 Other Tau protein Dynactin DCTN1 Tubulins TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3 Catenins Alpha catenin Beta catenin APC Plakoglobin ( gamma catenin ) Delta catenin GAN Membrane Dystrophin Dystroglycan Utrophin Ankyrin ANK1 ANK2 ANK3 Spectrin SPTA1 SPTAN1 SPTB SPTBN1 SPTBN2 SPTBN4 SPTBN5 Other Plakins Corneodesmosin Desmoplakin Dystonin Envoplakin MACF1 Periplakin Plectin Talin TLN1 Vinculin Plakophilin PKP1 PKP2 Nonhuman Major sperm proteins Prokaryotic cytoskeleton Crescentin FtsZ MreB See also : cytoskeletal defects GND : 4121944 - 2 NDL : 00576209 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Cytoskeleton&oldid=815981217 '' Categories : Cell anatomy Cytoskeleton Hidden categories : Articles which use infobox templates with no data rows Wikipedia articles with GND identifiers Talk Contents About Wikipedia বাংলা Български Bosanski Català Čeština Cymraeg Dansk Deutsch Eesti Ελληνικά Español Esperanto Euskara فارسی Français Gaelg Galego 한국어 Հայերեն हिन्दी Hrvatski Bahasa Indonesia Íslenska Italiano עברית Қазақша Latina Latviešu Lëtzebuergesch Lietuvių Magyar Македонски Nederlands 日本 語 Norsk Occitan Polski Português Română Русский Scots සිංහල Simple English سنڌي Slovenčina Slovenščina کوردی Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska Tagalog தமிழ் ไทย Українська اردو Tiếng Việt 中文 Edit links This page was last edited on 18 December 2017, at 13 : 28. 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Question: which type of cytoskeletal protein is also involved in muscle contractions
Answer: actin