Topical medication - wikipedia Topical medication This article is about topical medications. For other uses, see Topic ( disambiguation ). This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. ( December 2008 ) A medical professional applies nose drops. Instilling eye medication A topical medication is a medication that is applied to a particular place on or in the body. Most often topical administration means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a tooth. The word topical derives from Greek τοπικός topikos, `` of a place ''. Contents 1 Local versus systemic effect 2 Choice of base formulation 3 Classes 3.1 Topical solution 3.2 Lotion 3.3 Shake lotion 3.4 Cream 3.5 Ointment 3.6 Gel 3.7 Foam 3.8 Transdermal patch 3.9 Powder 3.10 Solid 3.11 Sponge 3.12 Tape 3.13 Vapor 3.14 Paste 3.15 Tincture 4 See also 5 References 6 External links Local versus systemic effect The definition of the topical route of administration sometimes states that both the application location and the pharmacodynamic effect thereof is local. A transdermal patch which delivers medication is applied to the skin. The patch is labelled with the time and date of administration as well as the administrator 's initials. In other cases, topical is defined as applied to a localized area of the body or to the surface of a body part regardless of the location of the effect. By this definition, topical administration also includes transdermal application, where the substance is administered onto the skin but is absorbed into the body to attain systemic distribution. Such medications are generally hydrophobic chemicals, such as steroid hormones. Specific types include transdermal patches have become a popular means of administering some drugs for birth control, hormone replacement therapy, and prevention of motion sickness. One example of an antibiotic that may be applied topically is chloramphenicol. If defined strictly as having local effect, the topical route of administration can also include enteral administration of medications that are poorly absorbable by the gastrointestinal tract. One poorly absorbable antibiotic is vancomycin, which is recommended by mouth as a treatment for severe Clostridium difficile colitis. Choice of base formulation A medication 's potency often is changed with its base. For example, some topical steroids will be classified one or two strengths higher when moving from cream to ointment. As a rule of thumb, an ointment base is more occlusive and will drive the medication into the skin more rapidly than a solution or cream base. The manufacturer of each topical product has total control over the content of the base of a medication. Although containing the same active ingredients, one manufacturer 's cream might be more acidic than the next, which could cause skin irritation or change its absorption rate. For example, a vaginal formulation of miconazole antifungal cream might irritate the skin less than an athlete foot formulation of miconazole cream. These variations can, on occasion, result in different clinical outcomes, even though the active ingredient is the same. No comparative potency labeling exists to ensure equal efficacy between brands of topical steroids ( percentage of oil vs water dramatically affect the potency of topical steroid ). Studies have confirmed that the potency of some topical steroid products may differ according to manufacturer or brand. An example of this is the case of brand name Valisone cream and Kenalog cream in clinical studies have demonstrated significantly better vasoconstrictions than some forms of this drug produced by generic drug manufacturers. However, in a simple base like an ointment, much less variation between manufacturers is common. In dermatology, the base of a topical medication is often as important as the medication itself. It is extremely important to receive a medication in the correct base, before applying to the skin. A pharmacist should not substitute an ointment for a cream, or vice versa, as the potency of the medication can change. Some physicians use a thick ointment to replace the waterproof barrier of the inflamed skin in the treatment of eczema, and a cream might not accomplish the same clinical intention Classes There are many general classes, with no clear dividing line between similar formulations. As a result, what the manufacturer 's marketing department chooses to list on the label of a topical medication might be completely different from what the form would normally be called. For example, Eucerin `` cream '' is more appropriately described as an ointment than as a cream. Topical solution Topical solutions can be marketed as rinses, sprays, or drops, and are generally of low viscosity and often use water or alcohol in the base. The solution can cause drying of the skin if alcohol is used in the base. These are usually a powder dissolved in water, alcohol, and sometimes oil. Alcohol in topical steroids can frequently cause drying if it is used as a base ingredient. There is significant variability between brands. There is a risk of irritation, depending on the preservative ( s ) and fragrances used in the base. Some examples of topical solutions are given below : Aluminium acetate topical solution : This is colorless, with a faint acetous odour and sweetish taste. It is applied topically as an astringent after dilution with 10 - 40 parts of water. This is used in many types of dermatologic lotions, creams, and pastes. Commercial premeasured and packed tablets and powders are available for this preparation. Povidone iodine topical solution : This is a chemical complex of iodine with polyvinylpyrrolidone, the agent being a polymer having an average molecular weight of 40,000. The povidone iodine contains 10 % available iodine, slowly released when applied to skin. This preparation is employed topically as a surgical scrub and non irritating antiseptic solution, with its effectiveness being directly attributed to the presence and release of iodine from the complex. Commercial product : Betadine solution. Lotion Lotions are similar to solutions but are thicker and tend to be more emollient in nature than solution. They are usually an oil mixed with water, and more often than not have less alcohol than solutions. Lotions can be drying if they contain a high amount of alcohol. There is a significant variability in the ingredients between different lotions. Shake lotion A mixture that separates into two or three parts with time. Frequently an oil mixed with a water - based solution needs to be shaken into suspension before use. `` Shake well before use ''. Cream A cream is an emulsion of oil and water in approximately equal proportions. It penetrates the stratum corneum outer layer of skin wall. Cream is thicker than lotion, and maintains its shape when removed from its container. It tends to be moderate in moisturizing tendency. For topical steroid products, oil - in - water emulsions are common. Creams have a significant risk of causing immunological sensitization due to preservatives. It has a high rate of acceptance by patients. There is a great variation in ingredients, composition, pH, and tolerance among generic brands. Ointment Metal case for Cruz Roja ointment from Mexico ( beginning of the 20th century ) from the permanent collection of the Museo del Objeto del Objeto. An ointment is a homogeneous, viscous, semi-solid preparation, most commonly a greasy, thick oil ( oil 80 % - water 20 % ) with a high viscosity, that is intended for external application to the skin or mucous membranes. Ointments have a water number that defines the maximum amount of water that it can contain. They are used as emollients or for the application of active ingredients to the skin for protective, therapeutic, or prophylactic purposes and where a degree of occlusion is desired. Ointments are used topically on a variety of body surfaces. These include the skin and the mucous membranes of the eye ( an eye ointment ), chest, vulva, anus, and nose. An ointment may or may not be medicated. Ointments are usually very moisturizing, and good for dry skin. They have a low risk of sensitization due to having few ingredients beyond the base oil or fat, and low irritation risk. There is typically little variability between brands of drugs. They are often disliked by patients due to greasiness. The vehicle of an ointment is known as the ointment base. The choice of a base depends upon the clinical indication for the ointment. The different types of ointment bases are : Hydrocarbon bases, e.g. hard paraffin, soft paraffin, microcrystalline wax and ceresine Absorption bases, e.g. wool fat, beeswax Water - soluble bases, e.g. macrogols 200, 300, 400 Emulsifying bases, e.g. emulsifying wax, cetrimide Vegetable oils, e.g. olive oil, coconut oil, sesame oil, almond oil and peanut oil. The medicaments are dispersed in the base and are divided after penetrating the living cells of the skin. The water number of an ointment is the maximum quantity of water that 100g of a base can contain at 20 ° C. Ointments are formulated using hydrophobic, hydrophilic, or water - emulsifying bases to provide preparations that are immiscible, miscible, or emulsifiable with skin secretions. They can also be derived from hydrocarbon ( fatty ), absorption, water - removable, or water - soluble bases. Evaluation of ointments Drug content Release of medicament from base Medicament penetration Consistency of the preparation Absorption of medicament into blood stream Irritant effect Properties which affect choice of an ointment base are : Stability Penetrability Solvent property Irritant effects Ease of application and removal Methods of preparation of ointments Trituration : In this finely subdivided insoluble medicaments are evenly distributed by grinding with a small amount of the base followed by dilution with gradually increasing amounts of the base. Fusion : In this method the ingredients are melted together in descending order of their melting points and stirred to ensure homogeneity. Gel Gels are thicker than liquids. Gels are often a semisolid emulsion sometimes using alcohol as a solvent for the active ingredient. Some gels liquefy at body temperature. Gel tends to be cellulose cut with alcohol or acetone. Gels tend to be self - drying. Gels tend to have greatly variable ingredients between brands. Gels carry a significant risk of inducing hypersensitivity due to fragrances and preservatives. Gel is useful for hairy areas and body folds. In applying gel one should avoid fissures in the skin, due to the stinging effect of the alcohol base. Gel enjoys a high rate of acceptance due to its cosmetic elegance. Foam Foam can be seen with topical steroid marketed for the scalp. Transdermal patch Transdermal patches can be a very precise time released method of delivering a drug. Cutting a patch in half might affect the dose delivered. The release of the active component from a transdermal delivery system ( patch ) may be controlled by diffusion through the adhesive which covers the whole patch, by diffusion through a membrane which may only have adhesive on the patch rim or drug release may be controlled by release from a polymer matrix. Cutting a patch might cause rapid dehydration of the base of the medicine and affect the rate of diffusion. Powder Powder is either the pure drug by itself ( talcum powder ), or is made of the drug mixed in a carrier such as corn starch or corn cob powder ( Zeosorb AF - miconazole powder ). Can be used as an inhaled topical ( cocaine powder used in nasal surgery ). Solid Medication may be placed in a solid form. Examples are deodorant, antiperspirants, astringents, and hemostatic agents. Some solids melt when they reach body temperature ( e.g. rectal suppositories ). Sponge Certain contraceptive methods rely on sponge as a carrier of a liquid medicine. Lemon juice embedded in a sponge has been used as a primitive contraception in some cultures. Tape Cordran tape is an example of a topical steroid applied under occlusion by tape. This greatly increases the potency and absorption of the topical steroid and is used to treat inflammatory skin diseases. Vapor Some medications are applied as an ointment or gel, and reach the mucous membrane via vaporization. Examples are nasal topical decongestants and smelling salt. Paste Paste combines three agents - oil, water, and powder. It is an ointment in which a powder is suspended. Paste Tincture A tincture is a skin preparation that has a high percentage of alcohol. It would normally be used as a drug vehicle if drying of the area is desired. See also Medical portal Liniment Unguent Finger tip unit Topical anesthetic Topical antibiotic Topical corticosteroids Topical decongestant Topical steroid References Goodman & Gilman 's The Pharmacological Basis of Therapeutics Dr. David Edwards - Dentistry Microbiology Lecture series Jump up ^ `` Psoriasis - Treatment ''. Medical Reference. University of Maryland Medical System. 2009. Jump up ^ `` topical ''. Merriam - Webster dictionary. Retrieved 2017 - 07 - 30. Jump up ^ thefreedictionary.com > topical Citing : The American Heritage Dictionary of the English Language, Fourth Edition, 2000 Jump up ^ `` topical ''. dictionary.com. Retrieved 2017 - 07 - 30. Jump up ^ `` Vancocin ''. The American Society of Health - System Pharmacists. Retrieved Sep 4, 2015. ^ Jump up to : Wolverton, SE. Comprehensive Dermatologic Drug Therapy. WB Saunders. 2001. pp 563 - 572. Jump up ^ Singh Malik, D ; Mital, N ; Kaur, G ( 2016 ). `` Topical drug delivery systems : a patent review ''. Expert opinion on therapeutic patents. 26 ( 2 ) : 213 -- 28. doi : 10.1517 / 13543776.2016. 1131267. PMID 26651499. Jump up ^ Baranowski, P ; Karolewicz, B ; Gajda, M ; Pluta, J ( 2014 ). `` Ophthalmic drug dosage forms : characterisation and research methods ''. TheScientificWorldJournal. 2014 : 861904. doi : 10.1155 / 2014 / 861904. PMC 3977496. PMID 24772038. Jump up ^ Smith, KA ; Rudmik, L ( 2016 ). `` Delivery of Topical Therapies ''. Advances in oto - rhino - laryngology. 79 : 114 -- 20. doi : 10.1159 / 000445145. PMID 27466853. Jump up ^ ansels pharmaceutical dosage form p.g # 371 ^ Jump up to : Wolverton, S. Comprehensive Dermatologic Drug Therapy. p. 13. ) Jump up ^ `` Doctor, why are you prescribing an ointment ? '' ; American Academy of Dermatology External links History of ointments Routes of administration, dosage forms Oral Digestive tract ( enteral ) Solids Pill Tablet Capsule Pastille Time release technology Osmotic delivery system ( OROS ) Liquids Decoction Elixir Electuary Emulsion Extended - release syrup Effervescent powder or tablet Herbal tea Hydrogel Molecular encapsulation Powder Softgel Solution Suspension Syrup Syrup Concentrate for dilution and / or addition of carbonated water Tincture Buccal ( sublabial ), sublingual Solids Orally disintegrating tablet ( ODT ) Film Lollipop Sublingual drops Lozenges Effervescent buccal tablet Chewing gum Liquids Mouthwash Toothpaste Ointment Oral spray Respiratory tract Solids Smoking device Dry - powder inhaler ( DPI ) 0 0 Liquids Anaesthetic vaporizer Vaporizer Nebulizer Metered - dose inhaler ( MDI ) Gas Oxygen mask and Nasal cannula Oxygen concentrator Anaesthetic machine Relative analgesia machine Ophthalmic, otologic, nasal Nasal spray Ear drops Eye drops Ointment Hydrogel Nanosphere suspension Insufflation Mucoadhesive microdisc ( microsphere tablet ) Urogenital Ointment Pessary ( vaginal suppository ) Vaginal ring Vaginal douche Intrauterine device ( IUD ) Extra-amniotic infusion Intravesical infusion Rectal ( enteral ) Ointment Suppository Enema Solution Hydrogel Murphy drip Nutrient enema Dermal Ointment Topical cream Topical gel Liniment Paste Film DMSO drug solution Electrophoretic dermal delivery system Hydrogel Liposomes Transfersome vesicles Cream Lotion Lip balm Medicated shampoo Dermal patch Transdermal patch Contact ( rubbed into break in the skin ) Transdermal spray Jet injector Injection, infusion ( into tissue / blood ) Skin Intradermal Subcutaneous Transdermal implant Organs Intracavernous Intravitreal Intra-articular injection Transscleral Central nervous system Intracerebral Intrathecal Epidural Circulatory, musculoskeletal Intravenous Intracardiac Intramuscular Intraosseous Intraperitoneal Nanocell injection Patient - Controlled Analgesia pump PIC line WikiProject Pharmacy portal Retrieved from `` https://en.wikipedia.org/w/index.php?title=Topical_medication&oldid=818323691 '' Categories : Medical terminology Routes of administration Ointments Drug delivery devices Dosage forms Hidden categories : Articles needing additional references from December 2008 All articles needing additional references Talk Contents About Wikipedia Dansk Deutsch فارسی Ido ಕನ್ನಡ مازِرونی 日本 語 Română Русский Српски / srpski Srpskohrvatski / српскохрватски 中文 Edit links This page was last edited on 2 January 2018, at 22 : 13. 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Question: method of administering a drug by topical friction over skin is called
Answer: transdermal application