Enzyme - linked receptor - wikipedia Enzyme - linked receptor An enzyme - linked receptor, also known as a catalytic receptor, is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side. Hence a catalytic receptor is an integral membrane protein possessing both enzymatic catalytic and receptor functions. They have two important domains, an extra-cellular ligand binding domain and an intracellular domain, which has a Catalytic function ; and a transmembrane helix. The signaling molecule binds to the receptor on the outside of the cell and causes a conformational change on the catalytic function located on the receptor inside the cell. Examples of the enzymatic activity include : Receptor tyrosine kinase, as in fibroblast growth factor receptor. Most enzyme - linked receptors are of this type. Serine / threonine - specific protein kinase, as in bone morphogenetic protein Guanylate cyclase, as in atrial natriuretic factor receptor Types The following is a list of the five major families of catalytic receptors : Family Member Gene Catalytic activity Endogenous ligands Synthetic ligands Erb ErbB1 ( epidermal growth factor receptor ) EGFR tyrosine kinase EC 2.7. 10.1 Epidermal growth factor, amphiregulin, betacellulin, epigen, epiregulin, HB - EGF, TGFa GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478 ErbB2 ERBB2 `` ErbB3 ERBB3 `` NRG - 1, NRG - 2 GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478 ErbB4 ERBB4 `` Betacellulin, epiregulin, HB - EGF, NRG - 1, NRG - 2, NRG - 3, NRG - 4 GW583340, gefitinib, erlotinib, tyrphostins AG879 and AG1478 GDNF ( glial cell - derived neurotrophic factor ) GFRa1 GFRa1 `` GDNF > neurturin > artemin GFRa2 GFRa2 `` Neurturin > GDNF GFRa3 GFRa3 `` Artemin GFRa4 GFRa4 `` Persephin NPR ( natriuretic peptide receptor ) NPR1 NPR1 guanylyl cyclase EC 4.6. 1.2 Atrial natriuretic peptide NPR2 NPR2 `` C - type natriuretic peptide NPR3 NPR3 `` Atrial natriuretic peptide NPR4 NPR4 `` Uroguanylin trk neurotrophin receptor TrkA NTRK1 tyrosine kinase EC 2.7. 10.1 Nerve growth factor > NT - 3 GW441756, tyrphostin AG879 TrkB NTRK2 `` Brain - derived neurotrophic factor, NT - 4 / NT - 5 > NT - 3 TrkC NTRK3 `` NT - 3 p75 NGFR `` NGF, BDNF, NT3, NT4 / 5 Toll - like TLR1 TLR1 `` TLR2 TLR2 `` Peptidoglycan TLR3 TLR3 `` polyIC, polyinosine - polycytosine TLR4 TLR4 `` LPS, lipopolysaccharide derived from Gram - negative bacteria TLR5 TLR5 `` Flagellin TLR6 TLR6 `` TLR7 TLR7 `` resiquimod, imiquimod TLR8 TLR8 `` TLR9 TLR9 `` CpG, DNA enriched in cytosine : guanosine pairs TLR10 TLR10 `` References Jump up ^ Ronald W. Dudek ( 1 November 2006 ). High - yield cell and molecular biology. Lippincott Williams & Wilkins. pp. 19 --. ISBN 978 - 0 - 7817 - 6887 - 0. Retrieved 16 December 2010. Jump up ^ Alexander SP, Mathie A, Peters JA ( February 2007 ). `` Catalytic Receptors ''. Br. J. Pharmacol. 150 Suppl 1 ( S1 ) : S122 -- 7. doi : 10.1038 / sj. bjp. 0707205. PMC 2013840. Jump up ^ lecture10 Jump up ^ Alexander SP, Mathie A, Peters JA ( February 2007 ). `` Catalytic receptors : ErbB family ''. Br. J. Pharmacol. 150 Suppl 1 : S146. doi : 10.1038 / sj. bjp. 0706476. Jump up ^ Alexander SP, Mathie A, Peters JA ( February 2007 ). `` Catalytic receptors : GDNF family ''. Br. J. Pharmacol. 150 Suppl 1 : S147. doi : 10.1038 / sj. bjp. 0706477. Jump up ^ Alexander SP, Mathie A, Peters JA ( February 2007 ). `` Catalytic receptors : Natriuretic peptide family ''. Br. J. Pharmacol. 150 Suppl 1 : S148. doi : 10.1038 / sj. bjp. 0706478. Jump up ^ Alexander SP, Mathie A, Peters JA ( February 2007 ). `` Catalytic receptors : Neurotrophin family ''. Br. J. Pharmacol. 150 Suppl 1 : S149. doi : 10.1038 / sj. bjp. 0706479. Jump up ^ Alexander SP, Mathie A, Peters JA ( February 2007 ). `` Catalytic receptors : Toll - like receptor family ''. Br. J. Pharmacol. 150 Suppl 1 : S150. doi : 10.1038 / sj. bjp. 0706480. External links Diagram at scq.ubc.ca Cell surface receptors : enzyme - linked receptors Receptor protein serine / threonine kinase Bone morphogenetic protein receptors BMPR1 BMPR1A BMPR1B BMPR2 ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ACVRL1 Anti-Müllerian hormone receptor Receptor tyrosine kinase EGF receptor family EGFR ERBB2 ERBB3 ERBB4 Insulin receptor family IGF1R INSR INSRR PDGF receptor family CSF1R FLT3 KIT PDGFR PDGFRA PDGFRB FGF receptor family FGFR1 FGFR2 FGFR3 FGFR4 VEGF receptors family VEGFR1 VEGFR2 VEGFR3 VEGFR4 HGF receptor family MET RON Trk receptor family NTRK1 NTRK2 NTRK3 EPH receptor family EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB5 EPHB6 EPHX LTK receptor family LTK ALK TIE receptor family TIE TEK ROR receptor family ROR1 ROR2 DDR receptor family DDR1 DDR2 PTK7 receptor family PTK7 RYK receptor family RYK MuSK receptor family MUSK ROS receptor family ROS1 AATYK receptor family AATYK AATYK2 AATYK3 AXL receptor family AXL MER TYRO3 RET receptor family RET uncategorised STYK1 Guanylate cyclase - coupled receptor ANP : NPR1 NPR2 GUCY2C GUCY2D Receptor tyrosine phosphatase PTPRA PTPRB PTPRC PTPRD PTPRE PTPRF PTPRG PTPRH PTPRJ PTPRK PTPRM PTPRN PTPRN2 PTPRO PTPRQ PTPRR PTPRS PTPRT PTPRU PTPRZ Retrieved from `` https://en.wikipedia.org/w/index.php?title=Enzyme-linked_receptor&oldid=759542802 '' Categories : Integral membrane proteins Transmembrane receptors Talk About Wikipedia עברית Српски / srpski Edit links This page was last edited on 11 January 2017, at 20 : 22. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: where are the catalytic domains of receptor enzymes located
Answer: on the receptor inside the cell