Bifenthrin - wikipedia Bifenthrin Bifenthrin Names IUPAC name 2 - Methyl - 3 - phenylphenyl ) methyl ( 1S, 3S ) - 3 - ( ( Z ) - 2 - chloro - 3, 3, 3 - trifluoroprop - 1 - enyl ) - 2, 2 - dimethylcyclopropane - 1 - carboxylate Identifiers CAS Number 82657 - 04 - 3 3D model ( JSmol ) Interactive image Interactive image ChemSpider 9114004 ECHA InfoCard 100.120. 070 KEGG C10980 PubChem CID 10938769 UNII 6B66JED0KN InChI InChI = 1S / C23H22ClF3O2 / c1 - 14 - 16 ( 10 - 7 - 11 - 17 ( 14 ) 15 - 8 - 5 - 4 - 6 - 9 - 15 ) 13 - 29 - 21 ( 28 ) 20 - 18 ( 22 ( 20, 2 ) 3 ) 12 - 19 ( 24 ) 23 ( 25, 26 ) 27 / h4 - 12, 18, 20H, 13H2, 1 - 3H3 / b19 - 12 - / t18 -, 20 - / m1 / s1 Key : OMFRMAHOUUJSGP - JHEGMOCKSA - N InChI = 1 / 2C23H22ClF3O2 / c2 * 1 - 14 - 16 ( 10 - 7 - 11 - 17 ( 14 ) 15 - 8 - 5 - 4 - 6 - 9 - 15 ) 13 - 29 - 21 ( 28 ) 20 - 18 ( 22 ( 20, 2 ) 3 ) 12 - 19 ( 24 ) 23 ( 25, 26 ) 27 / h2 * 4 - 12, 18, 20H, 13H2, 1 - 3H3 / b2 * 19 - 12 - / t2 * 18 -, 20 - / m10 / s1 Key : OXCDWLBJSLVWHB - LKRLXIKPBY SMILES Cc1c ( cccc1c2ccccc2 ) COC ( = O ) C3C ( C3 ( C ) C ) C = C ( C ( F ) ( F ) F ) Cl Cl C ( = C / ( C @ @ H ) 3 ( C@H ) ( C ( = O ) OCc2cccc ( c1ccccc1 ) c2C ) C3 ( C ) C ) C ( F ) ( F ) F Properties Chemical formula C H Cl F O Molar mass 422.87 g mol Solubility in water 0.1 mg / L Except where otherwise noted, data are given for materials in their standard state ( at 25 ° C ( 77 ° F ), 100 kPa ). Y verify ( what is ? ) Infobox references Bifenthrin is a pyrethroid insecticide used primarily against the red imported fire ant by influencing its nervous system. It has a high toxicity to aquatic organisms. Although it is listed as a restricted use chemical in the United States, it is allowed to be sold for daily use, provided the product sold has a low concentration of bifenthrin. The chemical was discovered and developed by FMC Corporation. Products containing bifenthrin include Transport, Talstar, Maxxthor, Capture, Brigade, Bifenthrine, Ortho Home Defense Max, Bifen XTS, Bifen IT, Bifen L / P, Torant, Zipak, Scotts LawnPro Step 3, Wisdom TC Flowable, FMC 54800, Allectus, Ortho Max Pro and OMS3024 and mega wash from green planet. Contents 1 Chemical properties 2 Toxicodynamics 3 Toxicokinetics 3.1 Biotransformation 4 Use 5 Toxicology 5.1 Toxicity in animals 5.2 Toxicity in mammals 6 Regulation 7 References 8 External links Chemical properties Bifenthrin is poorly soluble in water and often remains in soil. Its residual half - life in soil is between 7 days and 8 months, depending on the soil type, with a low mobility in most soil types. Bifenthrin has the longest known residual time in soil of insecticides currently on the market. It is a white, waxy solid with a faint sweet smell. It is chemically synthesized in various forms, including powder, granules and pellets. However, it is not naturally occurring. Like other pyrethroids, bifenthrin is chiral ; it has different enantiomers which can have different effects. Bifenthrin is found in two enantiomers : 1S - cis - bifenthrin and 1R - cis - bifenthrin. 1S - cis - Bifenthrin is 3 - 4 times more toxic to humans than 1R - cis - bifenthrin, while the latter is more than 300 times more effective as a pesticide. Toxicodynamics The two types of pyrethroids are the ones with an α - cyanogroup and the ones without an α - cyanogroup. The neurotoxicity of bifenthrin is based on the affinity to the voltage - gated sodium channels ( both in insects, as well as in mammals ). The pyrethroids with an α - cyanogroup block the closing of the sodium - channel permanently, causing the membrane to be permanently depolarized. The resting potential will not be restored, and no further action potential can be generated. The pyrethroids without an α - cyanogroup, to which bifenthrin belongs, are only able to bind to the sodium channel transiently. This will result in after potentials and eventual continuous firing of axons. The resting potential is not affected by these pyrethroids. Bifenthrin will open the sodium channel for a shorter period than other pyrethroids. The mechanism in mammals and invertebrates is not different, but the effect on mammals is much less due to higher body temperature, higher body volume, and lower affinity of bifenthrin to sodium channels. Toxicokinetics Numerous studies have been conducted on the half life of bifenthrin in soil, water, and air under different conditions, such as aerobic or anaerobic, and at different temperatures and pH. It is more likely to remain in the soil and not so much in water ( it is hydrophobic ), nor in the air ( it is unlikely to volatize because of its physical properties ). Because of the water - insolubility of bifenthrin, it will not rapidly cause contamination of ground water. However, some contamination might occur by soil - bound bifenthrin to surface water through runoff. For an overview of the environmental degradation of bifenthrin, see figure below. The main path of degradation results in 4 ' - hydroxy bifenthrin. Biotransformation Pyrethroids are much less toxic in mammals than they are in insects and fish, because mammals have the ability to rapidly break the ester bond in bifenthrin and break the substance into its inactive acid and alcohol components : In humans and rats, bifenthrin is degraded by the cytochrome p450 - family. Use This section 's tone or style may not reflect the encyclopedic tone used on Wikipedia. See Wikipedia 's guide to writing better articles for suggestions. ( April 2015 ) On a large scale, bifenthrin is often used against red imported fire ants. It is also effective against aphids, worms, ants, gnats, moths, beetles, earwigs, grasshoppers, mites, midges, spiders, ticks, yellow jackets, maggots, thrips, caterpillars, flies, fleas, and termites. It is mostly used in orchards, nurseries, and homes. In the agricultural sector, it is used in great amounts on certain crops, such as corn. About 70 % of all hops and raspberries cultured in the United States are treated with bifenthrin. Bifenthrin is used by the textile industry to protect woollen products from insect attack. It was introduced as an alternative to permethrin - based agents, due to greater efficacy against keratinophagous insects, better wash - fastness, and lower aquatic toxicity. Bifenthrin is not at all toxic to plants. Though it does not have a large toxicological risk towards mammals or birds, bifenthrin is able to accumulate in food, so it might be dangerous to mammals or birds in some scenarios. Toxicology Toxicity in animals Mosquitoes Bifenthrin is an effective pesticide to use against malaria and filaria vector mosquitoes. It is still effective when a resistance to other pyrethroids is found. Mosquito nets and indoor walls can be treated with bifenthrin to keep more mosquitoes away. Bifenthrin is an effectively used insecticide, but the risk is high of it working only for a short time. Mosquitoes can develop a resistance to it, as well. Aquatic life Bifenthrin is hardly soluble in water, so nearly all bifenthrin will stay in the sediment, but it is very harmful for the aquatic life. Even in small concentrations, fish and other aquatic animals are affected by bifenthrin. One of the reasons for the high sensitivity of fish is fish have a slow metabolism. Bifenthrin will stay longer in the system of the fish. Another reason for the high sensitivity of fish is the effect of bifenthrin as ATPase - inhibitor. The gills need ATP to control the osmotic balance of oxygen. If the fish is no longer capable of taking up oxygen because ATP can no longer be used, the fish will die. In cold water, bifenthrin is even more dangerous. pH and calcium concentration are also factors that influence the toxicity. Vertebrates are less sensitive to the effects of bifenthrin as ATPase - inhibitor. Bees In bees, the lethal concentration ( LC ) of bifenthrin is about 17 mg / l. At sublethal concentrations, bifenthrin reduces the fecundity of bees, decreases the rate at which bee larvae develop into adults, and increases their immature periods. Table of LD values Species LD Female rats 54 mg / kg Male rats 70 mg / kg Mice 43 mg / kg Mallard ducks 1280 ppm Bobwhite quail 4450 ppm Rainbow trout 0.00015 mg / l Bluegill 0.00035 mg / l Daphnia 0.0016 mg / l Toxicity in mammals Chemical consequences Bifenthrin and other synthetic pyrethroids are being used in agriculture in increasing amounts because of the high efficiency of these substances in killing insects, the low toxicity for mammals, and good biodegradability. However, because of its success, they are being used more often ( also indoors ) and high exposure of bifenthrin to humans can occur. Carcinogenicity The U.S. EPA classified bifenthrin as a Category C, possible human carcinogen. This rating is based on an increased rate of urinary bladder tumors in mice, adenoma and adenocarcinoma of the liver in male mice, and bronchioalveolar adenomas and adenocarcinomas of the lung in some female mice. Neurotoxicity for humans Exposure to bifenthrin can be achieved either by skin contact or ingestion. Skin contact is not toxic, apart from a slight tingling sensation on the specific location of contact. Ingestion is toxic, although only slightly. Commercially available bifenthrin ( Ortho Home Defense Max, for example ), however, can induce toxic effects in those concentrations, because the added chemicals which improve the sustainability either potentiate bifenthrin or are toxic on their own. Symptoms of excessive exposure are nausea, headaches, hypersensitivity for touch and sound, and irritation of the skin and the eyes. Regulation The EPA monitors and regulates the use of pesticides in the United States. Bifenthrin is classified as a restricted - use pesticide, meaning it is allowed to be legally sold only by certified pesticide applicators. For everyday use, it is allowed to be sold in lower concentrations. Bifenthrin has been approved for use against the Rasberry crazy ant in the Houston, Texas, area, under a special `` crisis exemption '' from the Texas Department of Agriculture and the EPA. The chemical is only approved for use in Texas counties experiencing `` confirmed infestations '' of the newly imported, invasive ant species. The EPA has classified bifenthrin as a class C carcinogen, a possible human carcinogen based on a test with mice, which showed increased development of certain tumors. An acute and chronic reference dose ( RfD ) for bifenthrin has been established, based on animal studies. The reference dose resembles the estimated quantity of a chemical which a person could be exposed to every day ( or a one - time exposure for the acute RfD ) without any appreciable risk of adverse health effects. The acute reference dose ( RfD ) for bifenthrin is 0.328 mg / kg bodyweight / day. The chronic reference dose ( RfD ) for bifenthrin is 0.013 mg / kg bodyweight / day. Bifenthrin was included in a biocide ban proposed by the Swedish Chemicals Agency, because of its carcinogenic effect. This was approved by the European Parliament in 2009. Pesticides containing bifenthrin were withdrawn from use in the European Union. They have since been reinstated. References ^ Jump up to : ( 1 ), Toxipedia ^ Jump up to : Liu Huigang, Zhao Meirong, Zhang Cong, Ma Yun, Liu Weiping ( 2008 ). `` Enantioselective cytotoxicity of the insecticide bifenthrin on a human amnion epithelial ( FL ) cell line ''. Toxicology. 253 ( 1 - 3 ) : 89 -- 96. doi : 10.1016 / j. tox. 2008.08. 015. CS1 maint : Multiple names : authors list ( link ) Jump up ^ Lund Albert E., Narahashi Toshio ( 1983 ). `` Kinetics of sodium channel modification as the basis for the variation in the nerve membrane effects of pyrethroids and DDT analogs ''. Pesticide Biochemistry and Physiology. 20 ( 2 ) : 203 -- 216. doi : 10.1016 / 0048 - 3575 ( 83 ) 90025 - 1. ^ Jump up to : ( 2 ), Bifenthrin Technical Fact Sheet, NPIC Jump up ^ ( 3 ), In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms Jump up ^ Ingham P.E., McNeil S.J., Sunderland M.R. ( 2012 ). `` Functional finishes for wool -- Eco considerations ''. Advanced Materials Research. 441 : 33 -- 43. doi : 10.4028 / www.scientific.net/amr.441.33. CS1 maint : Multiple names : authors list ( link ) Jump up ^ Al - Amin ( 2011 ). `` Evaluation of bifenthrin 80 sc, as a wall treatment against culex quinquefasciatus say ( diptera : culicidae ), a vector of wuchereria bancrofti cobbold, an etiological agent of human lymphatic filariasis ``. Terrestrial Arthropod Reviews. 4 ( 3 ) : 183 -- 202. doi : 10.1163 / 187498311X577405. Jump up ^ ( 4 ), Bifenthrin : A Useful Pyrethroid Insecticide for Treatment of Mosquito Nets Jump up ^ ( 5 ), Efficacy of bifenthrin - impregnated bednets against Anopheles funestus and pyrethroid - resistant Anopheles gambiae in North Cameroon Jump up ^ ( 6 ), Extension Toxicology Network Jump up ^ ( 7 ), Effects of acute exposure to bifenthrin on some haematological, biochemical and histopathological parameters of rainbow trout ( Oncorhynchus mykiss ) ^ Jump up to : Dai, Ping - Li ; Wang, Qiang ; Sun, Ji - Hu ; Liu, Feng ; Wang, Xing ; Wu, Yan - Yan ; Zhou, Ting ( 2010 ). `` Effects of sublethal concentrations of bifenthrin and deltamethrin on fecundity, growth, and development of the honeybeeApis mellifera ligustica ''. Environmental Toxicology and Chemistry. 29 ( 3 ) : 644 -- 9. doi : 10.1002 / etc. 67. PMID 20821489. Jump up ^ `` National Pesticide Information Center : Bifenthrin Technical Information Fact Sheet '' ( PDF ). Retrieved 2015 - 02 - 09. Jump up ^ ( 8 ), Pesticide Action Network Jump up ^ ( 9 ), Urban Entomology Jump up ^ ( 10 ), List of active substances in plant protection products which have been banned or withdrawn in Sweden during the period 1966 to 2000. Jump up ^ http://www.europarl.europa.eu/sides/getDoc.do?language=en&type=IM-PRESS&reference=20090112IPR45936 Jump up ^ http://news.agropages.com/News/NewsDetail---1433.htm Jump up ^ http://www.bizjournals.com/philadelphia/blog/natalie-kostelni/2012/07/bifenthrin-is-back-european-union.html External links Bifrenthrin general fact sheet - National Pesticide Information Center Pyrethrins and Pyrethroids Fact Sheet - National Pesticide Information Center Bifenthrin in the Pesticide Properties DataBase ( PPDB ) Pest control : Insecticides Carbamates Aldicarb Bendiocarb Carbaryl Carbofuran Ethienocarb Fenobucarb Oxamyl Methomyl Propoxur Inorganic compounds Aluminium phosphide Boric acid Chromated copper arsenate Copper ( II ) arsenate Copper ( I ) cyanide Diatomaceous earth Lead hydrogen arsenate Paris Green Scheele 's Green Insect growth regulators Benzoylureas Diflubenzuron Flufenoxuron Hydroprene Lufenuron Methoprene Pyriproxyfen Neonicotinoids Acetamiprid Clothianidin Dinotefuran Imidacloprid Nitenpyram Nithiazine Thiacloprid Thiamethoxam Organochlorides Aldrin Beta - HCH Carbon tetrachloride Chlordane Cyclodiene 1, 2 - DCB 1, 4 - DCB 1, 1 - DCE 1, 2 - DCE DDD DDE DDT Dicofol Dieldrin Endosulfan Endrin Heptachlor Kepone Lindane Methoxychlor Mirex Tetradifon Toxaphene Organophosphorus Acephate Azamethiphos Azinphos - methyl Bensulide Chlorethoxyfos Chlorfenvinphos Chlorpyrifos Chlorpyrifos - methyl Coumaphos Demeton - S - methyl Diazinon Dicrotophos Diisopropyl fluorophosphate Dimethoate Dioxathion Disulfoton Ethion Ethoprop Fenamiphos Fenitrothion Fenthion Fosthiazate Isoxathion Malathion Methamidophos Methidathion Mevinphos Monocrotophos Naled Omethoate Oxydemeton - methyl Parathion Parathion - methyl Phenthoate Phorate Phosalone Phosmet Phoxim Pirimiphos - methyl Quinalphos Temefos Tebupirimfos Terbufos Tetrachlorvinphos Tribufos Trichlorfon Pyrethroids Acrinathrin Allethrins Bifenthrin Bioallethrin Cyfluthrin Cyhalothrin Cypermethrin Cyphenothrin Deltamethrin Empenthrin Esfenvalerate Etofenprox Fenpropathrin Fenvalerate Flumethrin Imiprothrin Metofluthrin Permethrin Phenothrin Prallethrin Pyrethrin ( I, II ; chrysanthemic acid ) Pyrethrum Resmethrin Silafluofen Tefluthrin Tetramethrin Tralomethrin Transfluthrin Ryanoids Chlorantraniliprole Cyantraniliprole Flubendiamide Ryanodine Ryanodol Other chemicals Afoxolaner Amitraz Azadirachtin Buprofezin Chlordimeform Chlorfenapyr Cyromazine Fenazaquin Fenoxycarb Fipronil Fluralaner Hydramethylnon Indoxacarb Limonene Lotilaner Pyridaben Pyriprole Ryanodine Sarolaner Sesamex Spinosad Sulfluramid Tebufenozide Tebufenpyrad Veracevine Xanthone Metaflumizone Metabolites Oxon Malaoxon Paraoxon TCPy Biopesticides Bacillus thuringiensis Baculovirus Beauveria bassiana Beauveria brongniartii Metarhizium acridum Metarhizium anisopliae Nomuraea rileyi Lecanicillium lecanii Paecilomyces fumosoroseus Paenibacillus popilliae Purpureocillium lilacinum Retrieved from `` https://en.wikipedia.org/w/index.php?title=Bifenthrin&oldid=805883709 '' Categories : Pyrethroids Organochlorides Trifluoromethyl compounds FMC Corporation Biphenyls Hidden categories : CS1 maint : Multiple names : authors list Chemical articles with multiple compound IDs Multiple chemicals in an infobox that need indexing ECHA InfoCard ID from Wikidata Articles containing unverified chemical infoboxes Chembox image size set Wikipedia articles needing style editing from April 2015 All articles needing style editing All articles with unsourced statements Articles with unsourced statements from February 2015 Talk Contents About Wikipedia Čeština Deutsch Français 한국어 Српски / srpski Srpskohrvatski / српскохрватски ไทย Edit links This page was last edited on 18 October 2017, at 07 : 12. 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Question: what is the active ingredient in ortho home defense
Answer: Bifenthrin