Mean platelet volume - Wikipedia Mean platelet volume This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. ( December 2009 ) Mean platelet volume ( MPV ) is a machine - calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems. MPV is higher when there is destruction of platelets. This may be seen in inflammatory bowel disease, immune thrombocytopenic purpura ( ITP ), myeloproliferative diseases and Bernard - Soulier syndrome. It may also be related to pre-eclampsia, and recovery from transient hypoplasia. Abnormally low MPV values correlate with thrombocytopenia when it is due to impaired production as in aplastic anemia. In addition, low MPV can correlate with abnormally small platelet size, sometimes a symptom of a spectrum referred to as Wiskott - Aldrich Syndrome ( WAS ), caused by a genetic mutation of the WAS gene. Sample for MPV testing is obtained in a Lavender - Top EDTA tube. A typical range of platelet volumes is 9.4 -- 12.3 fL ( femtolitre ), equivalent to spheres 2.65 to 2.9 μm in diameter. Contents 1 Conditions associated with altered MPV 1.1 Decreased MPV 1.2 Increased MPV 2 Inherited Thrombocytopenia with Normal MPV 3 References 4 External links Conditions associated with altered MPV Decreased MPV Cytotoxic Chemotherapy Hypersplenism Reactive Thrombocytosis Iron Deficiency Anemia Hypothyroidism Acquired Immunodeficiency Syndrome ( AIDS ) Wiskott - Aldrich Syndrome X-Linked Thrombocytopenia Increased MPV Immune Thrombocytopenia Disseminated Intravascular Coagulation Myeloproliferative Disorders Administration of Erythropoietin / Thrombopoietin Recovery from transient hypoplasia Gray Platelet syndrome GATA - 1 mutation vWD Type 2B Platelet Type vWD Paris - Trousseau Syndrome Mediterranean Macrothrombocytopenia Bernard - Soulier Syndrome MYH9 - related disorders 21q11 deletion syndrome Acute & Chronic Myelogenous Leukemia Post-Splenectomy Vasculitis Megaloblastic Anemia Diabetes Mellitus Pre-eclampsia Chronic Renal Failure Respiratory Diseases Thrombocytopenia secondary to Sepsis Hyperthyroidism Myocardial Infarction Prosthetic Heart Valves Massive Hemorrhage Inherited Thrombocytopenia with Normal MPV ATRUS Syndrome Thrombocytopenia 2 ( THC2 ) Congenital Amegakaryocytic Thrombocytopenia TAR Syndrome Familial Platelet disorder with predisposition to AML References Jump up ^ ( 1 ), Lab Tests Online. Jump up ^ Liu, S ; Ren, J ; Han, G ; Wang, G ; Gu, G ; Xia, Q ; Li, J ( Oct 12, 2012 ). `` Mean platelet volume : a controversial marker of disease activity in Crohn 's disease ''. European Journal of Medical Research. 17 : 27. doi : 10.1186 / 2047 - 783x - 17 - 27. PMC 3519557. PMID 23058104. Jump up ^ ( 2 ), Arch Pathol Lab Med. Vol 133, September 2009 ; 1441 - 43... Jump up ^ Immune Deficiency Foundation http://primaryimmune.org/about-primary-immunodeficiencies/specific-disease-types/wiskott-aldrich-syndrome. Missing or empty title = ( help ) Jump up ^ `` CBC ( Complete Blood Count ), Blood ''. www.healthcare.uiowa.edu. Retrieved 2018 - 02 - 22. Jump up ^ `` Bernard - Soulier Syndrome Workup : Approach Considerations ''. emedicine.staging.medscape.com. Retrieved 2018 - 02 - 22. Jump up ^ McClatchey, Kenneth D. ( 2002 ). Clinical Laboratory Medicine. Lippincott Williams & Wilkins. ISBN 9780683307511. External links ( 3 ) Immune Deficiency Foundation entry for Wiskott - Aldrich Syndrome MPV Definition ( 4 ) Medicinenet.com : Thrombocytopenia ( 5 ) Diabetesexplained.com : MPV ( 6 ) ahajournals.org : Article related to MPV Bessman, JD ; Gilmer, PR ; Gardner, FH. `` Use of mean platelet volume improves detection of platelet disorders ''. Blood Cells. 11 : 127 -- 35. PMID 4074887. ( 7 ) Wisegeekcom : What is Mean Platelet Volume ( 8 ) Clinlabnavigator.com : MPV `` The template below ( Myeloid blood tests ) is being considered for merging. See templates for discussion to help reach a consensus. '' Myeloid blood tests ( CPT 85002 -- 85999 ) Clotting CBC Platelet count Mean platelet volume vWF : Ristocetin - induced platelet aggregation clotting factors : Prothrombin time Partial thromboplastin time Thrombin time Activated clotting time other / general : coagulation Bleeding time animal enzyme Reptilase time Ecarin clotting time Dilute Russell 's viper venom time Thromboelastography Thrombodynamics test fibrinolysis : Euglobulin lysis time D - dimer Red blood cell indices CBC RBC count Hematocrit Hemoglobin ratios : Mean corpuscular hemoglobin Mean corpuscular hemoglobin concentration Mean corpuscular volume Red blood cell distribution width Fetal hemoglobin : Apt -- Downey test Kleihauer -- Betke test Other Reticulocyte index Haptoglobin Mentzer index CFU - GM Nitro blue tetrazolium chloride test Complete blood count Absolute neutrophil count Other Blood film Blood viscosity Erythrocyte sedimentation rate This article about a medical condition affecting the circulatory system is a stub. You can help Wikipedia by expanding it. Retrieved from `` https://en.wikipedia.org/w/index.php?title=Mean_platelet_volume&oldid=842433565 '' Categories : Blood tests Circulatory disease stubs Hidden categories : Pages with citations lacking titles Pages with citations having bare URLs Articles needing additional references from December 2009 All articles needing additional references All stub articles Talk Contents About Wikipedia Hrvatski Srpskohrvatski / српскохрватски Edit links This page was last edited on 22 May 2018, at 12 : 17. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: what does it mean if my mean platelet volume is high
Answer: when there is destruction of platelets