Neural tube - wikipedia Neural tube This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. ( November 2016 ) Neural tube Transverse section of half of a chick embryo of forty - five hours ' incubation. The dorsal ( back ) surface of the embryo is toward the top of this page, while the ventral ( front ) surface is toward the bottom. ( Neural tube is in green. ) Chick embryo of thirty - three hours ' incubation, viewed from the dorsal aspect ( 30x magnification ). Details Carnegie stage 10 Precursor Neural groove Gives rise to Central nervous system ( brain and spinal cord ) Identifiers Latin tubus neuralis, tuba neuralis Code TE E5. 14.1. 0.0. 0.1 Anatomical terminology ( edit on Wikidata ) In the developing chordate ( including vertebrates ), the neural tube is the embryo 's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into the closed neural tube. In humans, neural tube closure usually occurs by the fourth week of pregnancy ( 28th day after conception ). The ectodermal wall of the tube forms the rudiment of the nervous system. The centre of the tube is the neural canal. Stages of neural tube formation. Contents 1 Development 2 Structure 3 Dorsal - ventral patterning 4 See also 5 References 6 External links Development The neural tube develops in two ways : primary neurulation and secondary neurulation. Primary neurulation divides the ectoderm into three cell types : The internally located neural tube The externally located epidermis The neural crest cells, which develop in the region between the neural tube and epidermis but then migrate to new locations Primary neurulation begins after the neural plate forms. The edges of the neural plate start to thicken and lift upward, forming the neural folds. The center of the neural plate remains grounded, allowing a U-shaped neural groove to form. This neural groove sets the boundary between the right and left sides of the embryo. The neural folds pinch in towards the midline of the embryo and fuse together to form the neural tube. In secondary neurulation, the cells of the neural plate form a cord - like structure that migrates inside the embryo and hollows to form the tube. Each organism uses primary and secondary neurulation to varying degrees. Neurulation in fish proceeds only via the secondary form. In avian species the posterior regions of the tube develop using secondary neurulation and the anterior regions develop by primary neurulation. In mammals, secondary neurulation begins around the 35th somite. Mammalian neural tubes close in the head in the opposite order that they close in the trunk. In the head : Neural crest cells migrate Neural tube closes Overlying ectoderm closes In the trunk : Overlying ectoderm closes Neural tube closes Neural crest cells migrate Structure Four neural tube subdivisions each eventually develop into distinct regions of the central nervous system by the division of neuroepithelial cells : the forebrain ( prosencephalon ), the midbrain ( mesencephalon ), the hindbrain ( rhombencephalon ) and the spinal cord. The prosencephalon further goes on to develop into the telencephalon ( cerebrum ) and the diencephalon ( the optic vesicles and hypothalamus ). The mesencephalon stays as the midbrain. The rhombencephalon develops into the metencephalon ( the pons and cerebellum ) and the myelencephalon ( the medulla oblongata ). For a short time, the neural tube is open both cranially and caudally. These openings, called neuropores, close during the fourth week in humans. Improper closure of the neuropores can result in neural tube defects such as anencephaly or spina bifida. The dorsal part of the neural tube contains the alar plate, which is associated primarily with sensation. The ventral part of the neural tube contains the basal plate, which is primarily associated with motor ( i.e., muscle ) control. Dorsal - ventral patterning The neural tube patterns along the dorsal - ventral axis to establish defined compartments of neural progenitor cells that lead to distinct classes of neurons. This patterning occurs early in development and results from the activity of several secreted signaling molecules. Sonic hedgehog ( Shh ) is a key player in patterning the ventral axis, while bone morphogenic proteins ( BMPs ) and Wnt family members play an important role in patterning the dorsal axis. Other factors shown to provide positional information to the neural progenitor cells include fibroblast growth factors ( FGFs ) and retinoic acid. Retinoic acid is required ventrally along with Shh to induce Pax6 and Olig2 during differentiation of motor neurons. Three main ventral cell types are established during early neural tube development : the floor plate cells, which form at the ventral midline during the neural fold stage ; as well as the more dorsally located motor neurons and interneurons. These cell types are specified by the secretion of the Shh from the notochord ( located ventrally to the neural tube ), and later from the floor plate cells. Shh acts as a morphogen, meaning that it acts in a concentration - dependent manner to specify cell types as it moves further from its source. The following is a proposed mechanism for how Shh patterns the ventral neural tube : A gradient of Shh that controls the expression of a group of homeodomain ( HD ) and basic Helix - Loop - Helix ( bHLH ) transcription factors is created. These transcription factors are grouped into two protein classes based on how Shh affects them. Class I is inhibited by Shh, whereas Class II is activated by Shh. These two classes of proteins then cross-regulate each other to create more - defined boundaries of expression. The different combinations of expression of these transcription factors along the dorsal - ventral axis of the neural tube are responsible for creating the identity of the neuronal progenitor cells. Five molecularly distinct groups of ventral neurons form from these neuronal progenitor cells in vitro. Also, the position at which these neuronal groups are generated in vivo can be predicted by the concentration of Shh required for their induction in vitro. Studies have shown that neural progenitors can evoke different responses based on the length of exposure to Shh, with a longer exposure time resulting in more ventral cell types. At the dorsal end of the neural tube, BMPs are responsible for neuronal patterning. BMP is initially secreted from the overlying ectoderm. A secondary signaling center is then established in the roof plate, the dorsal most structure of the neural tube. BMP from the dorsal end of the neural tube seems to act in the same concentration - dependent manner as Shh in the ventral end. This was shown using zebrafish mutants that had varying amounts of BMP signaling activity. Researchers observed changes in dorsal - ventral patterning, for example zebrafish deficient in certain BMPs showed a loss of dorsal sensory neurons and an expansion of interneurons. Shh secreted from the floor plate creates a gradient along the ventral neural tube. Shh functions in a concentration - dependent manner to specify ventral neuronal fates. V0 - V3 represent four different classes of ventral interneurons, and MN indicates motor neurons. See also Neural fold Neural plate Neurulation Neural tube defects Cdx protein family References This article incorporates text in the public domain from the 20th edition of Gray 's Anatomy ( 1918 ) ^ Jump up to : Gilbert, Scott F. Developmental Biology Eighth Edition. Sunderland, Massachusetts : Sinauer Associates, Inc., 2006. ^ Jump up to : Jessell TM ( 2000 ). `` Neuronal specification in the spinal cord : inductive signals and transcriptional codes ''. Nat Rev Genet. 1 ( 1 ) : 20 -- 9. doi : 10.1038 / 35049541. PMID 11262869. ^ Jump up to : Ulloa F, Marti E ( 2010 ). `` Wnt won the war : Antagonistic role of Wnt over Shh controls dorso - ventral patterning of the vertebrate neural tube ''. Developmental Dynamics. 239 ( 1 ) : 69 -- 76. doi : 10.1002 / dvdy. 22058. PMID 19681160. Jump up ^ Duester G ( 2008 ). `` Retinoic acid synthesis and signaling during early organogenesis ''. Cell. 134 ( 6 ) : 921 -- 931. doi : 10.1016 / j. cell. 2008.09. 002. PMC 2632951. PMID 18805086. Jump up ^ Patten I, Placzek M ( 2000 ). `` The role of Sonic hedgehog in neural tube patterning ''. Cell Mol Life Sci. 12 : 1695 -- 708. doi : 10.1007 / pl00000652. Jump up ^ Dessaud E, McMahon AP, Briscoe J ( 2008 ). `` Pattern formation in the vertebrate neural tube : a sonic hedgehog morphogen - regulated transcriptional network ''. Development. 135 ( 15 ) : 2489 -- 2503. doi : 10.1242 / dev. 009324. PMID 18621990. Jump up ^ Ericson J, Briscoe J, Rashbass P, van Heyningen V, Jessell TM ( 1997 ). `` Graded Sonic hedgehog signaling and the specification of cell fate in the ventral neural tube ''. Cold Spring Harb Symp Quant Biol. 62 : 451 -- 466. doi : 10.1101 / SQB. 1997.062. 01.053. PMID 9598380. Jump up ^ Stamataki D, Ulloa F, Tsoni SV, Mynett A, Briscoe J ( 2005 ). `` A gradient of Gli activity mediates graded Sonic hedgehog signaling in the neural tube ''. Genes Dev. 19 ( 5 ) : 626 -- 641. doi : 10.1101 / gad. 325905. PMC 551582. PMID 15741323. Jump up ^ Dessaud E, Yang LL, Hill K, et al. ( November 2007 ). `` Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism ''. Nature. 450 ( 7170 ) : 717 -- 20. doi : 10.1038 / nature06347. PMID 18046410. Jump up ^ Wilson L, Maden M ( 2005 ). `` The mechanisms of dorsoventral patterning in the vertebrate neural tube ''. Developmental Biology. 282 ( 1 ) : 1 -- 13. doi : 10.1016 / j. ydbio. 2005.02. 027. PMID 15936325. Jump up ^ Nguyen VH, Trout J, Connors SA, Andermann P, Weinberg E, Mullins MC ( 2000 ). `` Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway ''. Development. 127 ( 6 ) : 1209 -- 1220. PMID 10683174. External links Swiss embryology ( from UL, UB, and UF ) iperiodembry / carnegie03 Embryology at UNSW Notes / week3_5 Diagram at embryology.med.unsw.edu.au Diagram at brainviews.com Development of the nervous system Neurogenesis General Neural development Neurulation Neurula Notochord Neuroectoderm Neural plate Neural fold Neural groove Neuropoiesis Adult neurogenesis Neural crest Cranial neural crest Cardiac neural crest complex Truncal neural crest Neural tube Rostral neuropore Neuromere / Rhombomere Cephalic flexure Pontine flexure Alar plate Basal plate Glioblast Neuroblast Germinal matrix Eye Neural tube Optic vesicle Optic stalk Optic cup Surface ectoderm Lens placode Ear Otic placode Otic pit Otic vesicle Cells in humans derived from ectoderm Surface ectoderm Skin Trichocyte Keratinocyte Anterior pituitary Gonadotrope Corticotrope Thyrotrope Somatotrope Lactotroph Neural crest Peripheral nervous system Neuron Glia Schwann cell Satellite glial cell Neuroendocrine system Chromaffin cell Parafollicular cell Glomus cell Skin Melanocyte Nevus cell Merkel cell Teeth Odontoblast Cementoblast Eyes Corneal keratocyte Neural tube Central nervous system Neuron Glia ( Oligodendrocyte Astrocyte ) Ependyma Ependymocytes Pineal gland Pinealocyte Retrieved from `` https://en.wikipedia.org/w/index.php?title=Neural_tube&oldid=778213323 '' Categories : Wikipedia articles incorporating text from the 20th edition of Gray 's Anatomy ( 1918 ) Embryology of nervous system Neurulation Ectoderm Hidden categories : Articles needing additional references from November 2016 All articles needing additional references Medicine infobox template using GraySubject or GrayPage Talk Contents About Wikipedia Bosanski Català Čeština Deutsch Español Esperanto فارسی Français Galego Italiano Nederlands 日本 語 Polski Português Русский Slovenčina Suomi Svenska Українська Edit links This page was last edited on 1 May 2017, at 19 : 36. 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Question: when does the neural tube develops in a fetus
Answer: 28th day after conception