Reed -- Sternberg cell - wikipedia Reed -- Sternberg cell Micrograph showing a classic Reed -- Sternberg cell Micrograph showing a `` popcorn cell '', the Reed -- Sternberg cell variant seen in nodular lymphocyte predominant Hodgkin lymphoma. H&E stain Reed -- Sternberg cells ( also known as lacunar histiocytes for certain types ) are different giant cells found with light microscopy in biopsies from individuals with Hodgkin 's lymphoma ( a.k.a. Hodgkin 's disease, a type of lymphoma ). They are usually derived from B lymphocytes, classically considered crippled germinal center B cells, meaning they have not undergone hypermutation to express their antibody. Seen against a sea of B cells, they give the tissue a moth - eaten appearance. Classification of Hodgkin 's is based on the reactive cell mixture. Immunomarkers are used ( e.g., CD15 and CD30 ). Reed -- Sternberg cells are large 30 -- 50 microns and are either multinucleated or have a bilobed nucleus with prominent eosinophilic inclusion - like nucleoli ( thus resembling an `` owl 's eye '' appearance ). Reed -- Sternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin 's lymphoma -- the absence of Reed -- Sternberg cells has very high negative predictive value. They can also be found in reactive lymphadenopathy ( such as infectious mononucleosis immunoblasts which are RS like in appearance, carbamazepine associated lymphadenopathy ) and very rarely in other types of non-Hodgkin lymphomas. Anaplastic large cell lymphoma may show RS - like cells as well. Contents 1 History 2 Pathology 2.1 Hodgkin 's lymphoma 3 See also 4 References History They are named after Dorothy Reed Mendenhall and Carl Sternberg, who provided the first definitive microscopic descriptions of Hodgkin 's disease. Pathology Hodgkin 's lymphoma A special type of Reed -- Sternberg cells ( RSCs ) is the lacunar histiocyte, whose cytoplasm retracts when fixed in formalin, so the nuclei give the appearance of cells that lie with empty spaces ( called lacunae ) between them. These are characteristic of the nodular sclerosis subtype of Hodgkin 's lymphoma. Mummified RSCs ( compact nucleus, basophilic cytoplasm, no nucleolus ) are also associated with classical Hodgkin 's lymphoma while popcorn cells ( small cell with hyper - lobulated nucleus and small nucleoli ) are lymphohistiocytic ( L-H ) variant of Reed Sternberg cells and are associated with nodular lymphocyte predominant Hodgkin 's lymphoma ( NLPHL ). RSCs and one RSC cell line ( L1236 cells ) but not other RSC cell lines express very high levels of ALOX15 ( i.e., 15 - lipoxygenase - 1 ) or possibly ALOX15B ( i.e. 15 - lipoxygenase - 2 ), enzymes that metabolize arachidonic acid and various other polyunsaturated fatty acids to a wide array of bioactive products including in particular those of the 15 - Hydroperoxyeicosatetraenoic acid family of arachidonic acid metabolites. This is unusual in that lymphocytes typically express little or no ALOX15. It is suggested that ALOX15 and / or ALOX15B, perhaps operating through one of its arachidonic acid - derived products, the eoxins, contributes to the development and / or morphology of Hodgkin 's lymphoma. See also Non-Hodgkin lymphoma Hodgkin 's lymphoma References Jump up ^ Hartlapp I, Pallasch C, Weibert G, Kemkers A, Hummel M, Re D ( February 2009 ). `` Depsipeptide induces cell death in Hodgkin lymphoma - derived cell lines ''. Leuk. Res. 33 ( 7 ) : 929 -- 36. doi : 10.1016 / j. leukres. 2008.12. 013. PMID 19233470. Jump up ^ Reed D. On the pathological changes in Hodgkin 's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902 ; 10 : 133 -- 96. Jump up ^ Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898 ; 19 : 21 -- 90. ^ Jump up to : Mitchell, Richard Sheppard ; Kumar, Vinay ; Abbas, Abul K. ; Fausto, Nelson. Robbins Basic Pathology. Philadelphia : Saunders. ISBN 1 - 4160 - 2973 - 7. 8th edition. Jump up ^ FEBS J. 2008 Aug ; 275 ( 16 ) : 4222 -- 34. doi : 10.1111 / j. 1742 - 4658.2008. 06570 Jump up ^ Prostaglandins Other Lipid Mediat. 2009 Sep ; 89 ( 3 -- 4 ) : 120 -- 5. doi : 10.1016 / j. prostaglandins. 2008.12. 003 Jump up ^ Exp Cell Res. 2012 Feb 1 ; 318 ( 3 ) : 169 -- 76. doi : 10.1016 / j. yexcr. 2011.10. 017 Jump up ^ Exp Hematol. 2010 Feb ; 38 ( 2 ) : 116 -- 23. doi : 10.1016 / j. exphem. 2009 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Reed -- Sternberg_cell&oldid = 828432060 '' Categories : Histopathology Hodgkin 's lymphoma Talk Contents About Wikipedia Deutsch Español Français Italiano മലയാളം Polski Português Türkçe Edit links This page was last edited on 2 March 2018, at 14 : 23. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. 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Question: reed-sternberg cells in lymphatic tissue is diagnostic of
Answer: Hodgkin's lymphoma (a.k.a. Hodgkin's disease, a type of lymphoma)