Stress ( biology ) - wikipedia Stress ( biology ) For other kinds of stress, see Stress. This article has multiple issues. Please help improve it or discuss these issues on the talk page. ( Learn how and when to remove these template messages ) This article 's lead section does not adequately summarize key points of its contents. Please consider expanding the lead to provide an accessible overview of all important aspects of the article. Please discuss this issue on the article 's talk page. ( March 2014 ) This article may require cleanup to meet Wikipedia 's quality standards. The specific problem is : The original scope of this article may be compromised by the addition of terms and concepts which belong in a better article, such as Stress ( psychology ) Please help improve this article if you can. ( March 2014 ) Physiological or biological stress is an organism 's response to a stressor such as an environmental condition. Stress is the body 's method of reacting to a challenge. Stimuli that alter an organism 's environment are responded to by multiple systems in the body. The autonomic nervous system and hypothalamic - pituitary - adrenal ( HPA ) axis are two major systems that respond to stress. The sympathoadrenal medullary ( SAM ) axis may activate the fight or flight response through the sympathetic nervous system, which dedicates energy to more relevant bodily systems to acute adaption to stress, while the parasympathetic nervous system returns the body to homeostasis. The second major physiological stress, the HPA axis regulates the release of cortisol, which influences many bodily functions such as metabolic, psychological and immunological functions. The SAM and HPA axes are regulated by a wide variety of brain regions, including the limbic system, prefrontal cortex, amygdala, hypothalamus, and stria terminalis. Through these mechanisms, stress can alter memory functions, reward, immune function, metabolism and susceptibility to diseases. Definitions of stress differ ; however, one system proposed by Elliot and Eisdorfer suggests five types of stress. The five types of stress are labeled `` acute time limited stressors '', `` brief naturalistic stressors '', `` stressful event sequence '', `` chronic stressors '', and `` distant stressors ''. Acute time limited stressors involve short term challenges, while, on the other hand, brief naturalistic stressors involve an event that is normal but nevertheless challenging. Stressful event sequences are a stressor that occur, and continue to yield stress into the immediate future. Chronic stressors involve exposure to a long - term stressor and a distant stressor is a stressor that is n't immediate. Contents 1 Overview 2 Etymology and historical usage 3 Biological need for equilibrium 4 Biological background 5 Biology of stress 6 Effects of chronic stress 6.1 Immunological 6.2 Infectious 6.3 Chronic disease 6.4 Development 6.5 Psychopathology 7 Psychological concepts 7.1 Eustress 7.2 Coping 7.3 Cognitive appraisal 8 Assessment 8.1 Assessment 8.2 Health risk factors 8.3 General adaptation syndrome 8.3. 1 Stage 1 8.3. 2 Stage 2 8.3. 3 Stage 3 9 History in research 10 See also 11 Notes 12 References 13 External links Overview This article or section may need to be cleaned up. It has been merged from Stress ( psychology ) # Impact on health. There likely is a connection between stress and illness. Several studies have suggested such a link, theories of the stress -- illness link suggest that both acute and chronic stress can cause illness. According to these studies, both acute and chronic stress can lead to changes in behavior and in physiology. Behavioral changes can include smoking, changes in eating habits and physical activity. Physiological changes can include changes in sympathetic activation or HPA activity, and immunological function. However, there is much variability in the link between stress and illness. The HPA axis regulates many bodily functions, both behavioral and physiological, through the release of glucocorticoid hormones. The HPA axis activity varies according to the circadian rhythm, with a spike in the morning. The axis involves the release of corticotropin releasing hormone and vasopressin from the hypothalamus which stimulates the pituitary to secrete ACTH. ACTH may then stimulate the adrenal glands to secrete cortisol. The HPA axis is subject to negative feedback regulation as well. The release of CRH and VP are regulated by descending glutaminergic and GABAergic pathways from the amygdala, as well as noradrenergic projections. Increased cortisol usually acts to increase blood glucose, blood pressure, and surpasses lysosomal, and immunological activity. Under other circumstances, however, the activity may differ. Increased cortisol also favors habit based learning, by favoring memory consolidation of emotional memories. Selye demonstrated that stress decreases adaptability of an organism and proposed to describe the adaptability as a special resource, adaptation energy. In recent works, it is considered as an internal coordinate on the `` dominant path '' in the model of adaptation. Stress can make the individual more susceptible to physical illnesses like the common cold. Stressful events, such as job changes, may result in insomnia, impaired sleeping, and physical and psychological health complaints. Research indicates the type of stressor ( whether it 's acute or chronic ) and individual characteristics such as age and physical well - being before the onset of the stressor can combine to determine the effect of stress on an individual. An individual 's personality characteristics ( such as level of neuroticism ), genetics, and childhood experiences with major stressors and traumas may also dictate their response to stressors. Chronic stress and a lack of coping resources available or used by an individual can often lead to the development of psychological issues such as delusions depression and anxiety ( see below for further information ). This is particularly true regarding chronic stressors. These are stressors that may not be as intense as an acute stressor like a natural disaster or a major accident, but they persist over longer periods of time. These types of stressors tend to have a more negative effect on health because they are sustained and thus require the body 's physiological response to occur daily. This depletes the body 's energy more quickly and usually occurs over long periods of time, especially when these microstressors can not be avoided ( i.e. stress of living in a dangerous neighborhood ). See allostatic load for further discussion of the biological process by which chronic stress may affect the body. For example, studies have found that caregivers, particularly those of dementia patients, have higher levels of depression and slightly worse physical health than noncaregivers. It has long been believed that negative affective states, such as feelings of anxiety and depression, could influence the pathogenesis of physical disease. However recent studies done by the University of Wisconsin - Madison and other places have shown this to be untrue, it is n't stress itself that causes the increased risk of illness or death, it is actually the perception that stress is harmful. For example, when humans are under chronic stress, permanent changes in their physiological, emotional, and behavioral responses are most likely to occur and such changes could lead to disease. Chronic stress can include events such as caring for a spouse with dementia, or results from brief focal events that with long term effects, such as experiencing a sexual assault. Studies have also showed that psychological stress may directly contribute to the disproportionately high rates of coronary heart disease morbidity and mortality and its etiologic risk factors. Specifically, acute and chronic stress have been shown to raise serum lipids and are associated with clinical coronary events. However, it is possible for individuals to exhibit hardiness -- a term referring to the ability to be both chronically stressed and healthy. Even though psychological stress is often connected with illness or disease, most healthy individuals can still remain disease - free after being confronted with chronic stressful events. This suggests that there are individual differences in vulnerability to the potential pathogenic effects of stress ; individual differences in vulnerability arise due to both genetic and psychological factors. In addition, the age at which the stress is experienced can dictate its effect on health. Research suggests chronic stress at a young age can have lifelong effects on the biological, psychological, and behavioral responses to stress later in life. Recent studies have shown that severe psychological stress resulting in PTSD can also significantly affect parenting perception, behavior, neural activity and HPA - axis physiology in response to stressful parent - infant interactions. These recent studies support the existence of intergenerational effects of early chronic psychological stress. In animals, stress contributes to the initiation, growth, and metastasis of select tumors, but studies that try to link stress and cancer incidence in humans have had mixed results. This can be due to practical difficulties in designing and implementing adequate studies. Etymology and historical usage The term `` stress '' had none of its contemporary connotations before the 1920s. It is a form of the Middle English destresse, derived via Old French from the Latin stringere, `` to draw tight ''. The word had long been in use in physics to refer to the internal distribution of a force exerted on a material body, resulting in strain. In the 1920s and ' 30s, biological and psychological circles occasionally used the term to refer to a mental strain or to a harmful environmental agent that could cause illness. Walter Cannon used it in 1926 to refer to external factors that disrupted what he called homeostasis. But ``... stress as an explanation of lived experience is absent from both lay and expert life narratives before the 1930s ''. Physiological stress represents a wide range of physical responses that occur as a direct effect of a stressor causing an upset in the homeostasis of the body. Upon immediate disruption of either psychological or physical equilibrium the body responds by stimulating the nervous, endocrine, and immune systems. The reaction of these systems causes a number of physical changes that have both short - and long - term effects on the body. The Holmes and Rahe stress scale was developed as a method of assessing risk of disease from life changes. The scale lists both positive and negative changes that elicit stress. These include things such as a major holiday or marriage, or death of a spouse and firing from a job. Biological need for equilibrium Homeostasis is a concept central to the idea of stress. In biology, most biochemical processes strive to maintain equilibrium ( homeostasis ), a steady state that exists more as an ideal and less as an achievable condition. Environmental factors, internal or external stimuli, continually disrupt homeostasis ; an organism 's present condition is a state of constant flux moving about a homeostatic point that is that organism 's optimal condition for living. Factors causing an organism 's condition to diverge too far from homeostasis can be experienced as stress. A life - threatening situation such as a major physical trauma or prolonged starvation can greatly disrupt homeostasis. On the other hand, an organism 's attempt at restoring conditions back to or near homeostasis, often consuming energy and natural resources, can also be interpreted as stress. The ambiguity in defining this phenomenon was first recognized by Hans Selye ( 1907 -- 1982 ) in 1926. In 1951 a commentator loosely summarized Selye 's view of stress as something that ``... in addition to being itself, was also the cause of itself, and the result of itself ''. First to use the term in a biological context, Selye continued to define stress as `` the non-specific response of the body to any demand placed upon it ''. As of 2011 neuroscientists such as Bruce McEwen and Jaap Koolhaas believe that stress, based on years of empirical research, `` should be restricted to conditions where an environmental demand exceeds the natural regulatory capacity of an organism ''. Biological background Stress can have many profound effects on the human biological systems. Biology primarily attempts to explain major concepts of stress using a stimulus - response paradigm, broadly comparable to how a psychobiological sensory system operates. The central nervous system ( brain and spinal cord ) plays a crucial role in the body 's stress - related mechanisms. Whether one should interpret these mechanisms as the body 's response to a stressor or embody the act of stress itself is part of the ambiguity in defining what exactly stress is. Nevertheless, the central nervous system works closely with the body 's endocrine system to regulate these mechanisms. The sympathetic nervous system becomes primarily active during a stress response, regulating many of the body 's physiological functions in ways that ought to make an organism more adaptive to its environment. Below there follows a brief biological background of neuroanatomy and neurochemistry and how they relate to stress. Stress, either severe, acute stress or chronic low - grade stress may induce abnormalities in three principal regulatory systems in the body : serotonin systems, catecholamine systems, and the hypothalamic - pituitary - adrenocortical axis. Aggressive behavior has also been associated with abnormalities in these systems. Biology of stress Human brain : Hypothalamus =, amygdala =, hippocampus / fornix =, pons =, pituitary gland = The brain endocrine interactions are relevant in the translation of stress into physiological and psychological changes. The autonomic nervous system ( ANS ), as mentioned above, plays an important role in translating stress into a response. The ANS responds reflexively to both physical stressors ( for example baroreception ), and to higher level inputs from the brain. The ANS is composed of the parasympathetic nervous system and sympathetic nervous system, two branches that are both tonically active with opposing activities. The ANS directly innervates tissue through the postganglionic nerves, which is controlled by preganglionic neurons originating in the intermediolateral cell column. The ANS receives inputs from the medulla, hypothalamus, limbic system, prefrontal cortex, midbrain and monoamine nuclei. The activity of the sympathetic nervous system drives what sometimes called the `` fight or flight '' response. The fight or flight response to emergency or stress involves mydriasis, increased heart rate and force contraction, vasoconstriction, bronchodilation, glycogenolysis, gluconeogenesis, lipolysis, sweating, decreased motility of the digestive system, secretion of the epinephrine and cortisol from the adrenal medulla, and relaxation of the bladder wall. The parasympathetic nervous response, `` rest and digest '', involves return to maintaining homeostasis, and involves miosis, bronchoconstriction, increased activity of the digestive system, and contraction of the bladder walls. Complex relationships between protective and vulnerability factors on the effect of childhood home stress on psychological illness, cardiovascular illness and adaption have been observed. ANS related mechanisms are thought to contribute to increased risk of cardiovascular disease after major stressful events The HPA axis is a neuroendocrine system that mediates a stress response. Neurons in the hypothalamus, particularly the paraventricular nucleus, release vasopressin and corticotropin releasing hormone, which travels through the hypophysial portal vessel where it travels to and binds to corticotropin - releasing hormone receptor on the anterior pituitary gland. Multiple CRH peptides have been identified, and receptors have been identified on multiple areas of the brain, including the amygdala. However, CRH is the main regulatory molecule of the release of ACTH. The secretion of ACTH into systemic circulation allows it to bind to and activate Melanocortin receptor, where it stimulates the release of steroid hormones. Steroid hormones bind to glucocorticoid receptors in the brain, providing negative feedback by reducing ACTH release. Some evidence supports a second long term feedback that is non-sensitive to cortisol secretion. The PVN of the hypothalamus receives inputs from the nucleus of the solitary tract, and lamina terminalis. Through these inputs, it receives and can respond to changes in blood. The PVN innervation from the brain stem nuclei, particularly the noradrenergic nuclei stimulate CRH release. Other regions of the hypothalamus both directly and indirectly inhibit HPA axis activity. Hypothalamic neurons involved in regulating energy balance also influence HPA axis activity through the release of the neurotransmitters such as neuropeptide Y, which stimulates HPA axis activity. Generally, the amygdala stimulates, and the prefrontal cortex and hippocampus attenuate HPA axis activity, however complex relationships do exist between the regions. The immune system may be heavily influenced by stress. The sympathetic nervous system innervates various immunological structures, such as bone marrow and the spleen, allowing for it to regulate immune function. The adrenergic substances released by the sympathetic nervous system can also bind to and influence various immunological cells, further providing a connection between the systems. The HPA axis ultimately results in the release of cortisol, which generally has immunosuppressive effects. However, the effect of stress on the immune system is disputed, and various models have been proposed in an attempt to account for both the supposedly `` immunodeficiency '' linked diseases and diseases involving hyper activation of the immune system. The most recent model proposed to account for this suggests an push towards an imbalance of cellular immunity ( Th1 ) and humoral immunity ( Th2 ). The proposed imbalance involved hyperactivity of the Th2 system leading to some forms of immune hypersensitivity, while also increasing risk of some illnesses associated with decreased immune system function, such as infection and cancer. Effects of chronic stress Main article : Chronic stress Chronic stress is a term sometimes used to differentiate between acute stress. Definitions differ, and may be along the lines of continual activation of the stress response, stress that causes an allostatic shift in bodily functions, or just as `` prolonged stress ''. For example, results of one study demonstrated that individuals who reported relationship conflict lasting one month or longer have a greater risk of developing illness and show slower wound healing. Similarly, the effects that acute stressors have on the immune system may be increased when there is perceived stress and / or anxiety due to other events. For example, students who are taking exams show weaker immune responses if they also report stress due to daily hassles. While responses to acute stressors typically do not impose a health burden on young, healthy individuals, chronic stress in older or unhealthy individuals may have long - term effects that are detrimental to health. Immunological Acute time limited stressors, or stressors that lasted less than two hours, results in an up regulation of natural immunity and down regulation of specific immunity. This type of stress saw in increase in granulocytes, natural killer cells, IgA, Interleukin 6, and an increase in cell cytotoxicity. Brief naturalistic stressors elicit a shift from Th1 ( cellular ) to Th2 ( humoral ) immunity, while decreased T - cell proliferation, and natural killer cell cytotoxicity. Stressful event sequences did not elicit a consistent immune response, however some observations such as decreased T - Cell proliferation and cytotoxicity, increase or decrease in natural killer cell cytotoxicity, and an increase in mitogen PHA. Chronic stress elicited a shirt toward Th2 immunity, as well as decreased interleukin 2, T cell proliferation, and antibody response to the influenza vaccine. Distant stressors did not consistently elicit a change in immune function. Infectious Some studies have observed increased risk of upper respiratory tract infection during chronic life stress. In patients with HIV, increased life stress and cortisol was associated with poorer progression of HIV. Chronic disease A link has been suggested between chronic stress and cardiovascular disease. Stress appears to play a role in hypertension, and may further predispose people to other conditions associated with hypertension. Stress may also precipitate a more serious, or relapse into abuse of alcohol. Stress may also contribute to aging and chronic diseases in aging, such as depression and metabolic disorders. The immune system also plays a role in stress and the early stages of wound healing. It is responsible for preparing the tissue for repair and promoting recruitment of certain cells to the wound area. Consistent with the fact that stress alters the production of cytokines, Graham et al. found that chronic stress associated with care giving for a person with Alzheimer 's disease leads to delayed wound healing. Results indicated that biopsy wounds healed 25 % more slowly in the chronically stressed group, or those caring for a person with Alzheimer 's disease. Development Chronic stress has also been shown to impair developmental growth in children by lowering the pituitary gland 's production of growth hormone, as in children associated with a home environment involving serious marital discord, alcoholism, or child abuse. More generally, prenatal life, infancy, childhood, and adolescence are critical periods in which the vulnerability to stressors is particularly high. Psychopathology. Chronic stress is seen to affect the parts of the brain where memories are processed through and stored. When people feel stressed, stress hormones get over-secreted, which affects the brain. This secretion is made up of glucocorticoids, including cortisol, which are steroid hormones that the adrenal gland releases, although this can increase storage of flashbulb memories it decreases long - term potentation ( LTP ). The hippocampus is important in the brain for storing certain kinds of memories and damage to the hippocampus can cause trouble in storing new memories but old memories, memories stored before the damage, are not lost. Also high cortisol levels can be tied to the deterioration of the hippocampus and decline of memory that many older adults start to experience with age. Chronic stress also shifts learning, forming a preference for habit based learning, and decreased task flexibility and spatial working memory, probably through alterations of the dopaminergic systems. Stress may also increase reward associated with food, leading to weight gain and further changes in eating habits. Stress may contribute to various psychosomatic disorders, such as fibromyalgia, chronic fatigue syndrome, depression, and functional somatic syndromes. Psychological concepts Main article : Stress ( psychological ) Eustress Selye published in year 1975 a model dividing stress into eustress and distress. Where stress enhances function ( physical or mental, such as through strength training or challenging work ), it may be considered eustress. Persistent stress that is not resolved through coping or adaptation, deemed distress, may lead to anxiety or withdrawal ( depression ) behavior. The difference between experiences that result in eustress and those that result in distress is determined by the disparity between an experience ( real or imagined ) and personal expectations, and resources to cope with the stress. Alarming experiences, either real or imagined, can trigger a stress response. Coping Main article : Stress management Responses to stress include adaptation, psychological coping such as stress management, anxiety, and depression. Over the long term, distress can lead to diminished health and / or increased propensity to illness ; to avoid this, stress must be managed. Stress management encompasses techniques intended to equip a person with effective coping mechanisms for dealing with psychological stress, with stress defined as a person 's physiological response to an internal or external stimulus that triggers the fight - or - flight response. Stress management is effective when a person uses strategies to cope with or alter stressful situations. There are several ways of coping with stress, such as controlling the source of stress or learning to set limits and to say `` no '' to some of the demands that bosses or family members may make. A person 's capacity to tolerate the source of stress may be increased by thinking about another topic such as a hobby, listening to music, or spending time in a wilderness. A way to control stress is first dealing with what is causing the stress if it is something the individual has control over. Other methods to control stress and reduce it can be : to not procrastinate and leave tasks for last minute, do things you like, exercise, do breathing routines, go out with friends, and take a break. Having support from a loved one also helps a lot in reducing stress. A study was done and it showed that the power of having support from a loved one or just social support, lowered stress in the individuals. They gave painful shocks to married women 's ankles. On some trials women were able to hold their husbands hand, on other trials they held a strangers hand, and then held no one 's hand. When the women were holding their husbands hand, the response reduced in many brain areas. When holding the strangers hand the response reduced a little but not as much as when they were holding their husbands hand. Social support helps reduce stress but even more if the support is from a loved one. Cognitive appraisal Lazarus argued that, in order for a psychosocial situation to be stressful, it must be appraised as such. He argued that cognitive processes of appraisal are central in determining whether a situation is potentially threatening, constitutes a harm / loss or a challenge, or is benign. Both personal and environmental factors influence this primary appraisal, which then triggers the selection of coping processes. Problem - focused coping is directed at managing the problem, whereas emotion - focused coping processes are directed at managing the negative emotions. Secondary appraisal refers to the evaluation of the resources available to cope with the problem, and may alter the primary appraisal. In other words, primary appraisal includes the perception of how stressful the problem is and the secondary appraisal of estimating whether one has more than or less than adequate resources to deal with the problem that affects the overall appraisal of stressfulness. Further, coping is flexible in that, in general, the individual examines the effectiveness of the coping on the situation ; if it is not having the desired effect, s / he will, in general, try different strategies. Assessment Assessment Main articles : Holmes and Rahe stress scale and Stress ( psychological ) A renewed interest in salivary alpha amylase as a marker for stress has surfaced. Yamaguchi M, Yoshida H ( 2005 ) have analyzed a newly introduced hand - held device called the Cocorometer developed by Nipro Corporation of Japan. They state that this can be reliably used to analyze the amylase levels and is definitely a cheaper alternative as compared to the more expensive ELISA kits. The working consists of a meter and a saliva collecting chip, which can be inserted into the meter to give the readings. The levels of amylase obtained have been calibrated according to standard population, and can be categorized into four levels of severity. Measuring stress levels independent of differences in people 's personalities has been inherently difficult : Some people are able to process many stressors simultaneously, while others can barely address a few. Such tests as the Trier Social Stress Test attempted to isolate the effects of personalities on ability to handle stress in a laboratory environment. Other psychologists, however, proposed measuring stress indirectly, through self - tests. Because the amount of stressors in a person 's life often ( although not always ) correlates with the amount of stress that person experiences, researchers combine the results of stress and burnout self - tests. Stress tests help determine the number of stressors in a person 's life, while burnout tests determine the degree to which the person is close to the state of burnout. Combining both helps researchers gauge how likely additional stressors will make him or her experience mental exhaustion. Health risk factors Both negative and positive stressors can lead to stress. The intensity and duration of stress changes depending on the circumstances and emotional condition of the person suffering from it ( Arnold. E and Boggs. K. 2007 ). Some common categories and examples of stressors include : Sensory input such as pain, bright light, noise, temperatures, or environmental issues such as a lack of control over environmental circumstances, such as food, air and / or water quality, housing, health, freedom, or mobility. Social issues can also cause stress, such as struggles with conspecific or difficult individuals and social defeat, or relationship conflict, deception, or break ups, and major events such as birth and deaths, marriage, and divorce. Life experiences such as poverty, unemployment, clinical depression, obsessive compulsive disorder, heavy drinking, or insufficient sleep can also cause stress. Students and workers may face performance pressure stress from exams and project deadlines. Adverse experiences during development ( e.g. prenatal exposure to maternal stress, poor attachment histories, sexual abuse ) are thought to contribute to deficits in the maturity of an individual 's stress response systems. One evaluation of the different stresses in people 's lives is the Holmes and Rahe stress scale. General adaptation syndrome A diagram of the General Adaptation Syndrome model. Physiologists define stress as how the body reacts to a stressor, real or imagined, a stimulus that causes stress. Acute stressors affect an organism in the short term ; chronic stressors over the longer term. The general adaptation syndrome ( GAS ), developed by Hans Selye, is a profile of how organisms respond to stress ; GAS is characterized by three phases : a nonspecific mobilization phase, which promotes sympathetic nervous system activity ; a resistance phase, during which the organism makes efforts to cope with the threat ; and an exhaustion phase, which occurs if the organism fails to overcome the threat and depletes its physiological resources. Stage 1 Alarm is the first stage, which is divided into two phases : the shock phase and the antishock phase. Shock phase : During this phase, the body can endure changes such as hypovolemia, hypoosmolarity, hyponatremia, hypochloremia, hypoglycemia -- the stressor effect. This phase resembles Addison 's disease. The organism 's resistance to the stressor drops temporarily below the normal range and some level of shock ( e.g. circulatory shock ) may be experienced. Antishock phase : When the threat or stressor is identified or realized, the body starts to respond and is in a state of alarm. During this stage, the locus coeruleus / sympathetic nervous system is activated and catecholamines such as adrenaline are being produced, hence the fight - or - flight response. The result is : increased muscular tonus, increased blood pressure due to peripheral vasoconstriction and tachycardia, and increased glucose in blood. There is also some activation of the HPA axis, producing glucocorticoids ( cortisol, aka the S - hormone or stress - hormone ). Stage 2 Resistance is the second stage and increased secretion of glucocorticoids play a major role, intensifying the systemic response -- they have lipolytic, catabolic and antianabolic effects : increased glucose, fat and amino acid / protein concentration in blood. Moreover, they cause lymphocytopenia, eosinopenia, neutrophilia and polycythemia. In high doses, cortisol begins to act as a mineralocorticoid ( aldosterone ) and brings the body to a state similar to hyperaldosteronism. If the stressor persists, it becomes necessary to attempt some means of coping with the stress. Although the body begins to try to adapt to the strains or demands of the environment, the body can not keep this up indefinitely, so its resources are gradually depleted. Stage 3 The third stage could be either exhaustion or recovery : Recovery stage follows when the system 's compensation mechanisms have successfully overcome the stressor effect ( or have completely eliminated the factor which caused the stress ). The high glucose, fat and amino acid levels in blood prove useful for anabolic reactions, restoration of homeostasis and regeneration of cells. Exhaustion is the alternative third stage in the GAS model. At this point, all of the body 's resources are eventually depleted and the body is unable to maintain normal function. The initial autonomic nervous system symptoms may reappear ( sweating, raised heart rate, etc. ). If stage three is extended, long - term damage may result ( prolonged vasoconstriction results in ischemia which in turn leads to cell necrosis ), as the body 's immune system becomes exhausted, and bodily functions become impaired, resulting in decompensation. The result can manifest itself in obvious illnesses, such as general trouble with the digestive system ( e.g. occult bleeding, melena, constipation / obstipation ), diabetes, or even cardiovascular problems ( angina pectoris ), along with clinical depression and other mental illnesses. History in research The current usage of the word stress arose out of Selye 's 1930s experiments. He started to use the term to refer not just to the agent but to the state of the organism as it responded and adapted to the environment. His theories of a universal non-specific stress response attracted great interest and contention in academic physiology and he undertook extensive research programs and publication efforts. While the work attracted continued support from advocates of psychosomatic medicine, many in experimental physiology concluded that his concepts were too vague and unmeasurable. During the 1950s, Selye turned away from the laboratory to promote his concept through popular books and lecture tours. He wrote for both non-academic physicians and, in an international bestseller entitled Stress of Life, for the general public. A broad biopsychosocial concept of stress and adaptation offered the promise of helping everyone achieve health and happiness by successfully responding to changing global challenges and the problems of modern civilization. Selye coined the term `` eustress '' for positive stress, by contrast to distress. He argued that all people have a natural urge and need to work for their own benefit, a message that found favor with industrialists and governments. He also coined the term stressor to refer to the causative event or stimulus, as opposed to the resulting state of stress. Selye was in contact with the tobacco industry from 1958 and they were undeclared allies in litigation and the promotion of the concept of stress, clouding the link between smoking and cancer, and portraying smoking as a ' diversion ', on in Selye 's concept a ' deviation ', from environmental stress. From the late 1960s, academic psychologists started to adopt Selye 's concept ; they sought to quantify `` life stress '' by scoring `` significant life events '', and a large amount of research was undertaken to examine links between stress and disease of all kinds. By the late 1970s, stress had become the medical area of greatest concern to the general population, and more basic research was called for to better address the issue. There was also renewed laboratory research into the neuroendocrine, molecular, and immunological bases of stress, conceived as a useful heuristic not necessarily tied to Selye 's original hypotheses. The US military became a key center of stress research, attempting to understand and reduce combat neurosis and psychiatric casualties. The psychiatric diagnosis post-traumatic stress disorder ( PTSD ) was coined in the mid-1970s, in part through the efforts of anti-Vietnam War activists and the Vietnam Veterans Against the War, and Chaim F. Shatan. The condition was added to the Diagnostic and Statistical Manual of Mental Disorders as posttraumatic stress disorder in 1980. PTSD was considered a severe and ongoing emotional reaction to an extreme psychological trauma, and as such often associated with soldiers, police officers, and other emergency personnel. The stressor may involve threat to life ( or viewing the actual death of someone else ), serious physical injury, or threat to physical or psychological integrity. In some cases, it can also be from profound psychological and emotional trauma, apart from any actual physical harm or threat. Often, however, the two are combined. By the 1990s, `` stress '' had become an integral part of modern scientific understanding in all areas of physiology and human functioning, and one of the great metaphors of Western life. Focus grew on stress in certain settings, such as workplace stress, and stress management techniques were developed. The term also became a euphemism, a way of referring to problems and eliciting sympathy without being explicitly confessional, just `` stressed out ''. It came to cover a huge range of phenomena from mild irritation to the kind of severe problems that might result in a real breakdown of health. In popular usage, almost any event or situation between these extremes could be described as stressful. The American Psychological Association 's 2015 Stress In America Study found that nationwide stress is on the rise and that the three leading sources of stress were `` money '', `` family responsibility '', and `` work ''. See also Autonomic nervous system Defense physiology HPA axis Stress ( psychology ) Trier social stress test Xenohormesis Notes Jump up ^ Ulrich - Lai, Yvonne M. ; Herman, James P. ( 7 February 2017 ). `` Neural Regulation of Endocrine and Autonomic Stress Responses ''. Nature Reviews Neuroscience. 10 ( 6 ) : 397 -- 409. ISSN 1471 - 003X. PMC 4240627. PMID 19469025. doi : 10.1038 / nrn2647. ^ Jump up to : Stephens, Mary Ann C. ; Wand, Gary ( 1 January 2012 ). `` Stress and the HPA Axis ''. Alcohol Research : Current Reviews. 34 ( 4 ) : 468 -- 483. ISSN 2168 - 3492. PMC 3860380. PMID 23584113. ^ Jump up to : Segerstrom, Suzanne C. ; Miller, Gregory E. ( 7 February 2017 ). `` Psychological Stress and the Human Immune System : A Meta - Analytic Study of 30 Years of Inquiry ''. Psychological Bulletin. 130 ( 4 ) : 601 -- 630. ISSN 0033 - 2909. PMC 1361287. PMID 15250815. doi : 10.1037 / 0033 - 2909.130. 4.601. ^ Jump up to : Schneiderman, N. ; Ironson, G. ; Siegel, S.D. ( 2005 ). `` Stress and health : psychological, behavioral, and biological determinants ''. Annual Review of Clinical Psychology. 1 : 607 -- 628. PMC 2568977. PMID 17716101. doi : 10.1146 / annurev. clinpsy. 1.102803. 144141. Jump up ^ Herbert, T.B. ; Cohen, S. ( 1993 ). `` Stress and immunity in humans : a meta - analytic review ''. Psychosomatic Medicine. 55 ( 4 ) : 364 -- 379. doi : 10.1097 / 00006842 - 199307000 - 00004. Jump up ^ Ogden, J. ( 2007 ). Health Psychology : a textbook ( 4th ed. ), pages 281 -- 282 New York : McGraw - Hill ISBN 0335214711 ^ Jump up to : Aguilera, Greti ( 1 January 2011 ). `` HPA axis responsiveness to stress : Implications for healthy aging ''. Experimental Gerontology. 46 ( 2 -- 3 ) : 90 -- 95. ISSN 0531 - 5565. PMC 3026863. PMID 20833240. doi : 10.1016 / j. exger. 2010.08. 023. Jump up ^ Selye H ( 1938 ). `` Adaptation Energy ''. Nature. 141 ( 3577 ) : 926. doi : 10.1038 / 141926a0. Jump up ^ Gorban A.N. ; Tyukina T.A. ; Smirnova E.V. ; Pokidysheva L.I. ( 2016 ). `` Evolution of adaptation mechanisms : adaptation energy, stress, and oscillating death ''. J. Theor. Biol. doi : 10.1016 / j. jtbi. 2015.12. 017. Jump up ^ Cohen S. ; Doyle W.J. ; Skoner D.P. ; Rabin B.S. ; Gwaltney Jr J.M. ( 1997 ). `` Social ties and susceptibility to the common cold ''. JAMA : The Journal of the American Medical Association. 277 ( 24 ) : 1940 -- 1944. PMID 9200634. doi : 10.1001 / jama. 277.24. 1940. Jump up ^ Greubel, Jana and Kecklund, Göran. The Impact of Organizational Changes on Work Stress, Sleep, Recovery and Health. Industrial Health. Department for Psychology, University of Fribourg. Jump up ^ Jeronimus, B.F. ; Riese, H. ; Sanderman, R. ; Ormel, J. ( 2014 ). `` Mutual Reinforcement Between Neuroticism and Life Experiences : A Five - Wave, 16 - Year Study to Test Reciprocal Causation ''. Journal of Personality and Social Psychology. 107 ( 4 ) : 751 -- 64. PMID 25111305. doi : 10.1037 / a0037009. Jump up ^ Jeronimus, B.F. ; Ormel, J. ; Aleman, A. ; Penninx, B.W.J.H. ; Riese, H. ( 2013 ). `` Negative and positive life events are associated with small but lasting change in neuroticism ''. Psychological Medicine. 43 ( 11 ) : 2403 -- 15. PMID 23410535. doi : 10.1017 / s0033291713000159. Jump up ^ Kingston, Cara ; Schuurmans - Stekhoven, James ( 2016 ). `` Life hassles and delusional ideation : Scoping the potential role of cognitive and affective mediators, ''. Psychology and Psychotherapy : Theory, Research and Practice. 89 ( 4 ) : 445 -- 463. doi : 10.1111 / papt. 12089. Jump up ^ Schlotz W, Yim IS, Zoccola PM, Jansen L, Schulz P ( 2011 ). The perceived stress reactivity scale : Measurement invariance, stability, and validity in three countries. Psychol Assess. ( pp. 80 -- 94 ). Jump up ^ Pinquart M. ; Sörensen S. ( 2003 ). `` Differences between caregivers and noncaregivers in psychological health and physical health : a meta - analysis ''. Psychology and aging. 18 ( 2 ) : 250 -- 267. doi : 10.1037 / 0882 - 7974.18. 2.250. Jump up ^ Keller A, Litzelman K, Wisk LE, Maddox T, Cheng ER, Creswell PD, Witt WP ( 2012 ). `` Does the perception that stress affects health matter ? The association with health and mortality ''. Health Psychol. 31 : 677 -- 84. PMC 3374921. PMID 22201278. doi : 10.1037 / a0026743. Jump up ^ Jeronimus, B.F. ; Riese, H. ; Sanderman, R. ; Ormel, J. ( 2014 ). `` Mutual Reinforcement Between Neuroticism and Life Experiences : A Five - Wave, 16 - Year Study to Test Reciprocal Causation ''. Journal of Personality and Social Psychology. 107 ( 4 ) : 751 -- 64. PMID 25111305. doi : 10.1037 / a0037009. ^ Jump up to : Cohen, S ; Janicki - Deverts, D ; Miller, GE. ( 2007 ). `` Psychological Stress and Disease '' ( PDF ). JAMA. 298 ( 14 ) : 1685 -- 1687. PMID 17925521. doi : 10.1001 / jama. 298.14. 1685. Jump up ^ Calderon, R. ; Schneider, R.H. ; Alexander, C.N. ; Myers, H.F. ; Nidich, S.I. ; Haney, C. ( 1999 ). `` Stress, stress reduction and hypercholesterolemia in African Americans : a review ''. Ethnicity & Disease. 9 : 451 -- 462. ISSN 1049 - 510X. PMID 10600068. Jump up ^ Kobasa, S.C. ( 1982 ). The Hardy Personality : Toward a Social Psychology of Stress and Health. In G.S. Sanders & J. Suls ( Eds. ), Social Psychology of Health and Illness ( pp. 1 -- 25 ). Hillsdale, NJ : Lawrence Erlbaum Assoc. Jump up ^ Miller, G. ; Chen, E. ; Cole, S.W. ( 2009 ). `` Health psychology : Developing biologically plausible models linking the social world and physical health ''. Annual Review of Psychology. 60 : 501 -- 524. PMID 19035829. doi : 10.1146 / annurev. psych. 60.110707. 163551. Jump up ^ Schechter DS, Moser DA, Giacobino A, Stenz L, Gex - Fabry M, Adouan W, Cordero MI, Suardi F, Manini A, Sancho - Rossignol A, Merminod G, Aue T, Ansermet F, Dayer AG, Rusconi - Serpa S ( 2015 ). `` Methylation of NR3C1 is related to maternal PTSD, parenting stress and maternal medial prefrontal cortical activity in response to child separation among mothers with histories of violence exposure ''. Frontiers in Psychology. 6. doi : 10.3389 / fpsyg. 2015.00690. Jump up ^ Yehuda R. ; Halligan S.L. ; Bierer L.M. ( 2001 ). `` Relationship of parental trauma exposure and PTSD to PTSD, depressive and anxiety disorders in offspring ''. Journal of Psychiatric Research. 35 : 261 -- 270. doi : 10.1016 / s0022 - 3956 ( 01 ) 00032 - 2. ^ Jump up to : Keil R.M.K. ( 2004 ). `` Coping and Stress : A Conceptual Analysis ''. Journal of Advanced Nursing. 45 ( 6 ) : 659 -- 665. doi : 10.1046 / j. 1365 - 2648.2003. 02955. x. Jump up ^ W.B. Cannon ; Physiological Regulation of Normal States : Some Tentative Postulates Concerning Biological Homeostatics ; IN : A. Pettit ( ed. ) ; A Charles Richet : ses amis, ses collègues, ses élèves ; p. 91 ; Paris ; Éditions Médicales ; 1926. Jump up ^ Viner, Russell ( June 1999 ). `` Putting Stress in Life : Hans Selye and the Making of Stress Theory ''. Social Studies of Science. 29 ( 3 ) : 391 -- 410. ISSN 1460 - 3659. JSTOR 285410. doi : 10.1177 / 030631299029003003. Jump up ^ Captain Richard H. Rahe MC USNR ; Dr Ransom J. Arthur, MD ( 1 March 1978 ). `` Life Change and Illness Studies : Past History and Future Directions ''. Journal of Human Stress. 4 ( 1 ) : 3 -- 15. ISSN 0097 - 840X. PMID 346993. doi : 10.1080 / 0097840X. 1978.9934972. Jump up ^ Goldstein, David S. ; Kopin, Irwin J. ( January 2007 ). `` Evolution of concepts of stress ''. Stress : The International Journal on the Biology of Stress. 10 ( 2 ) : 109 -- 120. PMID 17514579. doi : 10.1080 / 10253890701288935. Jump up ^ Dattatreya, Shruthi ( 2014 ). `` Can Stress Take the Cost of Life ''. SSRN 2456211. doi : 10.2139 / ssrn. 2456211. Jump up ^ Worthington, James. `` Six ways to spot emotional manipulation before it destroys you ''. The Fusion Model. Retrieved 19 April 2015. Jump up ^ Humphrey, James H. ( 2005 ). Anthology of Stress Revisited : Selected Works Of James H. Humphrey. Foreword by Paul J. Rosch. Nova Science Publishers. p. viii. ISBN 9781594546402. Retrieved 2013 - 05 - 02. Even Selve ( sic ) had difficulties, and in helping him to prepare his First Annual report on Stress 1951, I included the comments of one physician published in the British Medical Journal, who, using citations from Selye 's articles concluded that ' Stress, in addition to being itself, was also the cause of itself, and the result of itself. ' Jump up ^ Selye, Hans ( 1978 ). The stress of life ( Rev. ed. ). New York : McGraw - Hill. ISBN 9780070562127. Jump up ^ Koolhaas J, et al. ( 2011 ). `` Stress revisited : A critical evaluation of the stress concept ''. Neuroscience and Biobehavioral Reviews. 35 ( 5 ) : 1291 -- 1301. doi : 10.1016 / j. neubiorev. 2011.02. 003. Jump up ^ Schacter, Daniel L. ; Gilbert, Daniel T. ; Wegner, Daniel M. ( 2011 ). Psychology ( 2nd ed. ). New York : Worth Publishers. p. 13.7. ISBN 1429237198. Jump up ^ WALTON K.G. ; LEVITSKY D.K. ( 2003 ). `` Effects of the Transcendental Meditation program on neuroendocrine abnormalities associated with aggression and crime. ''. Journal of Offender Rehabilitation. 36 ( 1 -- 4 ) : 67 -- 87. doi : 10.1300 / J076v36n01_04. Retrieved 29 February 2016. ^ Jump up to : McCorry, Laurie Kelly ( 15 August 2007 ). `` Physiology of the Autonomic Nervous System ''. American Journal of Pharmaceutical Education. 71 ( 4 ) : 78. ISSN 0002 - 9459. PMC 1959222. PMID 17786266. doi : 10.5688 / aj710478. ^ Jump up to : McKlveen, Jessica M. ; Myers, Brent ; Herman, James P. ( 7 February 2017 ). `` The Medial Prefrontal Cortex : Coordinator of Autonomic, Neuroendocrine, and Behavioral Responses to Stress ''. Journal of Neuroendocrinology. 27 ( 6 ) : 446 -- 456. ISSN 0953 - 8194. PMC 4580281. PMID 25737097. doi : 10.1111 / jne. 12272. Jump up ^ EL - SHEIKH, MONA ; ERATH, STEPHEN A. ( 7 February 2017 ). `` Family conflict, autonomic nervous system functioning, and child adaptation : State of the science and future directions ''. Development and Psychopathology. 23 ( 2 ) : 703 -- 721. ISSN 0954 - 5794. PMC 3695441. PMID 23786705. doi : 10.1017 / S0954579411000034. Jump up ^ Hering, Dagmara ; Lachowska, Kamila ; Schlaich, Markus ( 1 October 2015 ). `` Role of the Sympathetic Nervous System in Stress - Mediated Cardiovascular Disease ''. Current Hypertension Reports. 17 ( 10 ) : 80. ISSN 1534 - 3111. PMID 26318888. doi : 10.1007 / s11906 - 015 - 0594 - 5. Jump up ^ Smith, Sean M. ; Vale, Wylie W. ( 7 February 2017 ). `` The role of the hypothalamic - pituitary - adrenal axis in neuroendocrine responses to stress ''. Dialogues in Clinical Neuroscience. 8 ( 4 ) : 383 -- 395. ISSN 1294 - 8322. PMC 3181830. PMID 17290797. ^ Jump up to : Schneiderman, Neil ; Ironson, Gail ; Siegel, Scott D. ( 1 January 2005 ). `` STRESS AND HEALTH : Psychological, Behavioral, and Biological Determinants ''. Annual Review of Clinical Psychology. 1 : 607 -- 628. ISSN 1548 - 5943. PMC 2568977. PMID 17716101. doi : 10.1146 / annurev. clinpsy. 1.102803. 144141. Jump up ^ Herman, James P. ( 8 August 2013 ). `` Neural control of chronic stress adaptation ''. Frontiers in Behavioral Neuroscience. 7. ISSN 1662 - 5153. PMC 3737713. PMID 23964212. doi : 10.3389 / fnbeh. 2013.00061. ^ Jump up to : Graham J. ; Christian L. ; Kiecolt - Glaser J. ( 2006 ). `` Stress, Age, and Immune Function : Toward a Lifespan Approach ''. Journal of Behavioral Medicine. 29 ( 4 ) : 389 -- 400. doi : 10.1007 / s10865 - 006 - 9057 - 4. Jump up ^ Schneiderman N. ; Ironson G. ; Siegel S.D. ( 2005 ). `` Stress and health : psychological, behavioral, and biological determinants ''. Annual Review of Clinical Psychology. 1 ( 1 ) : 607 -- 628. PMC 2568977. PMID 17716101. doi : 10.1146 / annurev. clinpsy. 1.102803. 144141. Jump up ^ Spruill, Tanya M. ( 7 February 2017 ). `` Chronic Psychosocial Stress and Hypertension ''. Current Hypertension Reports. 12 ( 1 ) : 10 -- 16. ISSN 1522 - 6417. PMC 3694268. PMID 20425153. doi : 10.1007 / s11906 - 009 - 0084 - 8. Jump up ^ Khansari D. ; Murgo A. ; Faith R. ( May 1990 ). `` Effects of stress on the immune system ''. Immunology Today. 11 ( 5 ) : 170 -- 175. PMID 2186751. doi : 10.1016 / 0167 - 5699 ( 90 ) 90069 - l. Jump up ^ Powell, Brasel, & Blizzard, 1967. Jump up ^ Charmandari E, Achermann JC, Carel JC, Soder O, Chrousos GP ( 2012 ). `` Stress response and child health ''. Science Signaling ( Review ). 5 ( 248 ) : mr1. PMID 23112343. doi : 10.1126 / scisignal. 2003595. Jump up ^ Charmandari E, Kino T, Souvatzoglou E, Chrousos GP ( 2003 ). `` Pediatric stress : hormonal mediators and human development ''. Hormone Research ( Review ). 59 ( 4 ) : 161 -- 79. PMID 12649570. doi : 10.1159 / 000069325. Jump up ^ `` Renew - Stress on the Brain ''. The Franklin Institute. ^ Jump up to : Kalat, J.W. ( 2013 ). Biological Psychology. p. 383 Jump up ^ Kalat, J.W. ( 2013 ). Biological Psychology. p. 97 Jump up ^ Yau, Yvonne H.C. ; Potenza, Marc N. ( 7 February 2017 ). `` Stress and Eating Behaviors ''. Minerva Endocrinologica. 38 ( 3 ) : 255 -- 267. ISSN 0391 - 1977. PMC 4214609. PMID 24126546. Jump up ^ Clauw, Daniel J. ( 2014 ). `` Fibromyalgia ''. JAMA. 311 ( 15 ) : 1547 -- 55. PMID 24737367. doi : 10.1001 / jama. 2014.3266. Jump up ^ Wyller, Vegard Bruun ( 1 January 2007 ). `` The chronic fatigue syndrome -- an update ''. Acta Neurologica Scandinavica Supplementum. 187 : 7 -- 14. ISSN 0065 - 1427. PMID 17419822. doi : 10.1111 / j. 1600 - 0404.2007. 00840. x. Jump up ^ Saveanu, Radu V. ; Nemeroff, Charles B. ( March 2012 ). `` Etiology of Depression : Genetic and Environmental Factors ''. Psychiatric Clinics of North America. 35 ( 1 ) : 51 -- 71. doi : 10.1016 / j. psc. 2011.12. 001. Jump up ^ Afari, Niloofar ; Ahumada, Sandra M. ; Wright, Lisa Johnson ; Mostoufi, Sheeva ; Golnari, Golnaz ; Reis, Veronica ; Cuneo, Jessica Gundy ( 7 February 2017 ). `` Psychological Trauma and Functional Somatic Syndromes : A Systematic Review and Meta - Analysis ''. Psychosomatic Medicine. 76 ( 1 ) : 2 -- 11. ISSN 0033 - 3174. PMC 3894419. PMID 24336429. doi : 10.1097 / PSY. 0000000000000010. Jump up ^ Selye ( 1975 ). `` Confusion and controversy in the stress field ''. Journal of Human Stress. 1 ( 2 ) : 37 -- 44. PMID 1235113. doi : 10.1080 / 0097840X. 1975.9940406. Jump up ^ de Kloet, E. Ron ; Joëls, Marian ; Holsboer, Florian ( June 2005 ). `` Stress and the brain : from adaptation to disease ''. Nature Reviews Neuroscience. 6 ( 6 ) : 463 -- 475. PMID 15891777. doi : 10.1038 / nrn1683. Jump up ^ `` The Silent Denial of Stress in a Competitive World ''. The Silent Denial of Stress in a Competitive World. 2012 - 03 - 17. Retrieved 2012 - 03 - 17. Jump up ^ Lazarus, R.S. ( 1966 ). Psychological Stress and the Coping Process. New York : McGraw - Hill. Jump up ^ Aldwin, Carolyn ( 2007 ). Stress, Coping, and Development, Second Edition. New York : The Guilford Press. ISBN 1 - 57230 - 840 - 0. Jump up ^ Shankar, A.A. ; Dandekar, R.C. `` Assessment of stress in patients with Recurrent Aphthous Stomatitis, by salivary alpha amylase using a Cocorometer '' dissertation submitted for Oral Pathology to Maharashtra University of Health Sciences, Nashik in December 2009. Jump up ^ Truby, William ; `` Stress Test '', Stress Test : A self assessment, December, 2009. Jump up ^ Glavas, M.M. ; Weinberg, J. ( 2006 ). `` Stress, Alcohol Consumption, and the Hypothalamic - Pituitary - Adrenal Axis ''. In Yehuda, S. ; Mostofsky, D.I. Nutrients, Stress, and Medical Disorders. Totowa, NJ : Humana Press. pp. 165 -- 183. ISBN 978 - 1 - 58829 - 432 - 6. Jump up ^ Davis et al. ( June 2007 ). Prenatal Exposure to Maternal Depression and Cortisol Influences Infant Temperament. Journal of the American Academy of Child & Adolescent Psychiatry, v46 n6 p737. Jump up ^ O'Connor ; Heron ; Golding ; Beveridge ; Glover ( 2002 ). `` Maternal antenatal anxiety and children 's behavioural / emotional problems at 4 years ''. Br J Psychiatry. 180 : 478 -- 9. doi : 10.1192 / bjp. 180.6. 502. Jump up ^ Schore, Allan ( 2003 ). Affect Regulation & the Repair of the Self. New York : W.W. Norton. ISBN 0 - 393 - 70407 - 6. Jump up ^ Michael D. DeBellis, George P. Chrousos, Lorah D. Dorn, Lillian Burke, Karin Helmers, Mitchel A. Kling, Penelope K. Trickett, and Frank W. Putnam. Hypothalamic -- Pituitary -- Adrenal Axis Dysregulation in Sexually Abused Girls Jump up ^ Taylor, Shelley, and Sirois, Fuschia. ( 2012 ). Health Psychology 2nd Canadian Edition Jump up ^ Gozhenko, AI ; Gurkalova, IP ; Zukow, W ; Kwasnik, Z ; Mroczkowska, B. Gozhenko, AI ; Zukow, W ; Kwasnik, Z, eds. Pathology : Medical student 's library. Radom University. p. 272. ISBN 978 - 83 - 61047 - 18 - 6. OCLC 750538315. ^ Jump up to : Viner R ( 1999 ). `` Putting Stress in Life : Hans Selye and the Making of Stress Theory ''. Social Studies of Science. 29 ( 3 ) : 391 -- 410. JSTOR 285410. doi : 10.1177 / 030631299029003003. Jump up ^ Petticrew, Mark P. ; Lee, Kelley ( March 2011 ). `` The `` Father of Stress '' Meets `` Big Tobacco '' : Hans Selye and the Tobacco Industry ``. American Journal of Public Health. 101 ( 3 ) : 411 -- 418. ISSN 0090 - 0036. PMC 3036703. PMID 20466961. doi : 10.2105 / AJPH. 2009.177634. Jump up ^ Shalev, Arieh Y. ; Yehuda, Rachel ; Alexander C. McFarlane ( 2000 ). International handbook of human response to trauma. New York : Kluwer Academic / Plenum Press. ISBN 0 - 306 - 46095 - 5. ; on - line. Jump up ^ `` 2015 Stress in America Snapshot ''. www.apa.org. References Carlson, N.R. & Heth, C.D. ( 2007 ). ', ' Psychology the science of behaviour. 4th ed. Upper Saddle River, New Jersey : Pearson Education, Inc., 527. Petersen, C. ; Maier, S.F. ; Seligman, M.E.P. ( 1995 ). Learned Helplessness : A Theory for the Age of Personal Control. New York : Oxford University Press. ISBN 0 - 19 - 504467 - 3 Seligman, M.E.P. ( 1975 ). Helplessness : On Depression, Development, and Death. San Francisco : W.H. Freeman. ISBN 0 - 7167 - 2328 - X Seligman, M.E.P. ( 1990 ). Learned Optimism. New York : Knopf. ( Reissue edition, 1998, Free Press, ISBN 0 - 671 - 01911 - 2 ). Holmes T.H. ; Rahe R.H. ( 1967 ). `` The social readjustments rating scales ''. Journal of Psychosomatic Research. 11 ( 2 ) : 213 -- 218. PMID 6059863. doi : 10.1016 / 0022 - 3999 ( 67 ) 90010 - 4. `` Taming Stress '', Scientific American, September 2003 Joe, Marian ; Pu, Zhenwei ; Wiegert, Olof ; Oitzl, Melly S ; Krugers, Harm J ; et al. ( 2005 ). `` Learning Under Stress : How does it Work ? ''. Trends in Cognitive Sciences. 10 ( 4 ) : 152 -- 157. doi : 10.1016 / j. tics. 2006.02. 002. CS1 maint : Multiple names : authors list ( link ) Renner Katherine H ( 2010 ). `` Effects of Naturalistic Stressors on Cognitive Flexibility and Working Memory Task Performance ''. Neurocase. 16 ( 4 ) : 293 -- 300. doi : 10.1080 / 13554790903463601. External links Look up stress in Wiktionary, the free dictionary. The American Institute of Stress `` Research on Work - Related Stress '', European Agency for Safety and Health at Work ( EU - OSHA ) Coping With Stress Stages of GAS & Evolving the Definition Retrieved from `` https://en.wikipedia.org/w/index.php?title=Stress_(biology)&oldid=806260050 '' Categories : Stress Endocrine system Sympathetic nervous system Hidden categories : Use dmy dates from June 2015 Wikipedia introduction cleanup from March 2014 All pages needing cleanup Articles covered by WikiProject Wikify from March 2014 All articles covered by WikiProject Wikify Articles needing cleanup from March 2014 Cleanup tagged articles with a reason field from March 2014 Wikipedia pages needing cleanup from March 2014 All articles with unsourced statements Articles with unsourced statements from April 2015 Articles containing potentially dated statements from 2011 All articles containing potentially dated statements Articles with unsourced statements from August 2016 CS1 maint : Multiple names : authors list Talk Contents About Wikipedia Afrikaans Azərbaycanca تۆرکجه Беларуская Беларуская ( тарашкевіца ) ‎ Български Català Čeština Dansk Deutsch Eesti Ελληνικά Español Esperanto Euskara فارسی Français Gaeilge Galego 한국어 Հայերեն हिन्दी Hrvatski Bahasa Indonesia Íslenska Italiano עברית Қазақша Kurdî Кыргызча Latviešu Lietuvių Lingála Magyar मराठी مصرى Nederlands 日本 語 Norsk Patois Polski Português Română Русский Scots Shqip Simple English Slovenčina Slovenščina Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska தமிழ் Татарча / tatarça తెలుగు ไทย Türkçe Українська Vèneto Tiếng Việt 中文 Edit links This page was last edited on 20 October 2017, at 20 : 12. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: the adaptive physiologic response to stressful events is called
Answer: Stress management