Food allergy - wikipedia Food allergy Food allergy Hives on the back are a common allergy symptom. Specialty Emergency medicine Symptoms Itchiness, swelling of the tongue, vomiting, diarrhea, hives, trouble breathing, low blood pressure Usual onset Minutes to several hours of exposure Duration Long term, some may resolve Causes Immune response to food Risk factors Family history, vitamin D deficiency, obesity, high levels of cleanliness Diagnostic method Based on a medical history, elimination diet, skin prick test, oral food challenge Similar conditions Food intolerance, food poisoning Prevention Early exposure to potential allergens Treatment Avoiding the food in question, having a plan if exposure occurs, medical alert jewelry Medication Adrenaline ( epinephrine ) Frequency ~ 6 % ( developed world ) ( edit on Wikidata ) A food allergy is an abnormal immune response to food. The signs and symptoms may range from mild to severe. They may include itchiness, swelling of the tongue, vomiting, diarrhea, hives, trouble breathing, or low blood pressure. This typically occurs within minutes to several hours of exposure. When the symptoms are severe, it is known as anaphylaxis. Food intolerance and food poisoning are separate conditions. Common foods involved include cow 's milk, peanuts, eggs, shellfish, fish, tree nuts, soy, wheat, rice, and fruit. The common allergies vary depending on the country. Risk factors include a family history of allergies, vitamin D deficiency, obesity, and high levels of cleanliness. Allergies occur when immunoglobulin E ( IgE ), part of the body 's immune system, binds to food molecules. A protein in the food is usually the problem. This triggers the release of inflammatory chemicals such as histamine. Diagnosis is usually based on a medical history, elimination diet, skin prick test, blood tests for food - specific IgE antibodies, or oral food challenge. Early exposure to potential allergens may be protective. Management primarily involves avoiding the food in question and having a plan if exposure occurs. This plan may include giving adrenaline ( epinephrine ) and wearing medical alert jewelry. The benefits of allergen immunotherapy for food allergies is unclear, thus is not recommended as of 2015. Some types of food allergies among children resolve with age, including that to milk, eggs, and soy ; while others such as to nuts and shellfish typically do not. In the developed world, about 4 % to 8 % of people have at least one food allergy. They are more common in children than adults and appear to be increasing in frequency. Male children appear to be more commonly affected than females. Some allergies more commonly develop early in life, while others typically develop in later life. In developed countries, a large proportion of people believe they have food allergies when they actually do not have them. Contents 1 Signs and symptoms 2 Cause 2.1 Sensitization 2.2 Atopy 2.3 Cross-reactivity 3 Pathophysiology 3.1 Acute response 3.2 Late - phase response 4 Diagnosis 4.1 Differential diagnosis 5 Prevention 5.1 Inhalation exposure 6 Treatment 6.1 Epinephrine 6.2 Antihistamines 6.3 Steroids 7 Epidemiology 7.1 United States 8 Society and culture 8.1 Regulation of labelling 8.2 Genetically modified food 9 Research 10 See also 11 References 12 External links Signs and symptoms Food allergies usually have a fast onset ( from seconds to one hour ) and may include : Rash Hives Itching of mouth, lips, tongue, throat, eyes, skin, or other areas Swelling ( angioedema ) of lips, tongue, eyelids, or the whole face Difficulty swallowing Runny or congested nose Hoarse voice Wheezing and / or shortness of breath Diarrhea, abdominal pain, and / or stomach cramps Lightheadedness Fainting Nausea Vomiting In some cases, however, onset of symptoms may be delayed for hours. Symptoms of allergies vary from person to person. The amount of food needed to trigger a reaction also varies from person to person. Serious danger regarding allergies can begin when the respiratory tract or blood circulation is affected. The former can be indicated through wheezing and cyanosis. Poor blood circulation leads to a weak pulse, pale skin and fainting. A severe case of an allergic reaction, caused by symptoms affecting the respiratory tract and blood circulation, is called anaphylaxis. When symptoms are related to a drop in blood pressure, the person is said to be in anaphylactic shock. Anaphylaxis occurs when IgE antibodies are involved, and areas of the body that are not in direct contact with the food become affected and show symptoms. Those with asthma or an allergy to peanuts, tree nuts, or seafood are at greater risk for anaphylaxis. Cause Although sensitivity levels vary by country, the most common food allergies are allergies to milk, eggs, peanuts, tree nuts, seafood, shellfish, soy, and wheat. These are often referred to as `` the big eight ''. Allergies to seeds -- especially sesame -- seem to be increasing in many countries. An example an allergy more common to a particular region is that to rice in East Asia where it forms a large part of the diet. One of the most common food allergies is a sensitivity to peanuts, a member of the bean family. Peanut allergies may be severe, but children with peanut allergies sometimes outgrow them. Tree nuts, including cashews, Brazil nuts, hazelnuts, macadamia nuts, pecans, pistachios, pine nuts, coconuts, and walnuts, are also common allergens. Sufferers may be sensitive to one particular tree nut or to many different ones. Also, seeds, including sesame seeds and poppy seeds, contain oils where protein is present, which may elicit an allergic reaction. Egg allergies affect about one in 50 children but are frequently outgrown by children when they reach age five. Typically, the sensitivity is to proteins in the white, rather than the yolk. Milk from cows, goats, or sheep is another common food allergen, and many sufferers are also unable to tolerate dairy products such as cheese. A small portion of children with a milk allergy, roughly 10 %, have a reaction to beef. Beef contains a small amount of protein that is also present in cow 's milk. Seafood is one of the most common sources of food allergens ; people may be allergic to proteins found in fish, crustaceans, or shellfish. Other foods containing allergenic proteins include soy, wheat, fruits, vegetables, maize, spices, synthetic and natural colors, and chemical additives. Balsam of Peru, which is in various foods, is in the `` top five '' allergens most commonly causing patch test reactions in people referred to dermatology clinics. Sensitization An Institute of Medicine report says that food proteins contained in vaccines, such as gelatin, milk, or egg can cause sensitization ( development of allergy ) in vaccine recipients, to those food items. Atopy Food allergies develop more easily in people with the atopic syndrome, a very common combination of diseases : allergic rhinitis and conjunctivitis, eczema, and asthma. The syndrome has a strong inherited component ; a family history of allergic diseases can be indicative of the atopic syndrome. Cross-reactivity Some children who are allergic to cow 's milk protein also show a cross-sensitivity to soy - based products. Some infant formulas have their milk and soy proteins hydrolyzed, so when taken by infants, their immune systems do not recognize the allergen and they can safely consume the product. Hypoallergenic infant formulas can be based on proteins partially predigested to a less antigenic form. Other formulas, based on free amino acids, are the least antigenic and provide complete nutritional support in severe forms of milk allergy. People with latex allergy often also develop allergies to bananas, kiwifruit, avocados, and some other foods. Pathophysiology A histamine, the structure shown, causes a person to feel itchy during an allergic reaction. A common medication to stop this is an antihistamine, which fights the histamines in the person 's system. Conditions caused by food allergies are classified into three groups according to the mechanism of the allergic response : IgE - mediated ( classic ) -- the most common type, occurs shortly after eating and may involve anaphylaxis. Non-IgE mediated -- characterized by an immune response not involving immunoglobulin E ; may occur some hours after eating, complicating diagnosis IgE and / or non-IgE - mediated -- a hybrid of the above two types Allergic reactions are hyperactive responses of the immune system to generally innocuous substances. When immune cells encounter the allergenic protein, IgE antibodies are produced ; this is similar to the immune system 's reaction to foreign pathogens. The IgE antibodies identify the allergenic proteins as harmful and initiate the allergic reaction. The harmful proteins are those that do not break down due to the strong bonds of the protein. IgE antibodies bind to a receptor on the surface of the protein, creating a tag, just as a virus or parasite becomes tagged. Why some proteins do not denature and subsequently trigger allergic reactions and hypersensitivity while others do is not entirely clear. Hypersensitivities are categorized according to the parts of the immune system that are attacked and the amount of time it takes for the response to occur. The four types of hypersensitivity reaction are : type 1, immediate IgE - mediated ; type 2, cytotoxic ; type 3, immune complex - mediated ; and type 4, delayed cell - mediated. The pathophysiology of allergic responses can be divided into two phases. The first is an acute response that occurs immediately after exposure to an allergen. This phase can either subside or progress into a `` late - phase reaction '' which can substantially prolong the symptoms of a response, and result in tissue damage. Many food allergies are caused by hypersensitivities to particular proteins in different foods. Proteins have unique properties that allow them to become allergens, such as stabilizing forces in their tertiary and quaternary structures which prevent degradation during digestion. Many theoretically allergenic proteins can not survive the destructive environment of the digestive tract, thus do not trigger hypersensitive reactions. Acute response Degranulation process in allergy. 1 -- antigen 2 -- IgE antibody 3 -- FcεRI receptor 4 -- preformed mediators ( histamine, proteases, chemokines, heparin ) 5 -- granules 6 -- mast cell 7 -- newly formed mediators ( prostaglandins, leukotrienes, thromboxanes, PAF ) In the early stages of allergy, a type I hypersensitivity reaction against an allergen, encountered for the first time, causes a response in a type of immune cell called a T 2 lymphocyte, which belongs to a subset of T cells that produce a cytokine called interleukin - 4 ( IL - 4 ). These T 2 cells interact with other lymphocytes called B cells, whose role is the production of antibodies. Coupled with signals provided by IL - 4, this interaction stimulates the B cell to begin production of a large amount of a particular type of antibody known as IgE. Secreted IgE circulates in the blood and binds to an IgE - specific receptor ( a kind of Fc receptor called FcεRI ) on the surface of other kinds of immune cells called mast cells and basophils, which are both involved in the acute inflammatory response. The IgE - coated cells, at this stage, are sensitized to the allergen. If later exposure to the same allergen occurs, the allergen can bind to the IgE molecules held on the surface of the mast cells or basophils. Cross-linking of the IgE and Fc receptors occurs when more than one IgE - receptor complex interacts with the same allergenic molecule, and activates the sensitized cell. Activated mast cells and basophils undergo a process called degranulation, during which they release histamine and other inflammatory chemical mediators ( cytokines, interleukins, leukotrienes, and prostaglandins ) from their granules into the surrounding tissue causing several systemic effects, such as vasodilation, mucous secretion, nerve stimulation, and smooth - muscle contraction. This results in rhinorrhea, itchiness, dyspnea, and anaphylaxis. Depending on the individual, the allergen, and the mode of introduction, the symptoms can be system - wide ( classical anaphylaxis ), or localized to particular body systems ; asthma is localized to the respiratory system and eczema is localized to the dermis. Late - phase response After the chemical mediators of the acute response subside, late - phase responses can often occur due to the migration of other leukocytes such as neutrophils, lymphocytes, eosinophils, and macrophages to the initial site. The reaction is usually seen 2 -- 24 hours after the original reaction. Cytokines from mast cells may also play a role in the persistence of long - term effects. Late - phase responses seen in asthma are slightly different from those seen in other allergic responses, although they are still caused by release of mediators from eosinophils, and are still dependent on activity of T 2 cells. Diagnosis Skin testing on the arm is a common way for detecting an allergy, but it is not as effective as other tests. Patch test Diagnosis is usually based on a medical history, elimination diet, skin prick test, blood tests for food - specific IgE antibodies, or oral food challenge. For skin - prick tests, a tiny board with protruding needles is used. The allergens are placed either on the board or directly on the skin. The board is then placed on the skin, to puncture the skin and for the allergens to enter the body. If a hive appears, the person is considered positive for the allergy. This test only works for IgE antibodies. Allergic reactions caused by other antibodies can not be detected through skin - prick tests. Skin - prick testing is easy to do and results are available in minutes. Different allergists may use different devices for testing. Some use a `` bifurcated needle '', which looks like a fork with two prongs. Others use a `` multitest '', which may look like a small board with several pins sticking out of it. In these tests, a tiny amount of the suspected allergen is put onto the skin or into a testing device, and the device is placed on the skin to prick, or break through, the top layer of skin. This puts a small amount of the allergen under the skin. A hive will form at any spot where the person is allergic. This test generally yields a positive or negative result. It is good for quickly learning if a person is allergic to a particular food or not, because it detects IgE. Skin tests can not predict if a reaction would occur or what kind of reaction might occur if a person ingests that particular allergen. They can, however, confirm an allergy in light of a patient 's history of reactions to a particular food. Non-IgE - mediated allergies can not be detected by this method. Patch testing is used to determine if a specific substance causes allergic inflammation of the skin. It tests for delayed food reactions. Blood testing is another way to test for allergies ; however, it poses the same disadvantage and only detects IgE allergens and does not work for every possible allergen. Radioallergosorbent testing ( RAST ) is used to detect IgE antibodies present to a certain allergen. The score taken from the RAST is compared to predictive values, taken from a specific type of RAST. If the score is higher than the predictive values, a great chance the allergy is present in the person exists. One advantage of this test is that it can test many allergens at one time. A CAP - RAST has greater specificity than RAST ; it can show the amount of IgE present to each allergen. Researchers have been able to determine `` predictive values '' for certain foods, which can be compared to the RAST results. If a person 's RAST score is higher than the predictive value for that food, over a 95 % chance exists that patients will have an allergic reaction ( limited to rash and anaphylaxis reactions ) if they ingest that food. Currently, predictive values are available for milk, egg, peanut, fish, soy, and wheat. Blood tests allow for hundreds of allergens to be screened from a single sample, and cover food allergies as well as inhalants. However, non-IgE - mediated allergies can not be detected by this method. Other widely promoted tests such as the antigen leukocyte cellular antibody test and the food allergy profile are considered unproven methods, the use of which is not advised. Food challenges test for allergens other than those caused by IgE allergens. The allergen is given to the person in the form of a pill, so the person can ingest the allergen directly. The person is watched for signs and symptoms. The problem with food challenges is that they must be performed in the hospital under careful watch, due to the possibility of anaphylaxis. Food challenges, especially double - blind, placebo - controlled food challenges, are the gold standard for diagnosis of food allergies, including most non-IgE - mediated reactions. Blind food challenges involve packaging the suspected allergen into a capsule, giving it to the patient, and observing the patient for signs or symptoms of an allergic reaction. The best method for diagnosing food allergy is to be assessed by an allergist. The allergist will review the patient 's history and the symptoms or reactions that have been noted after food ingestion. If the allergist feels the symptoms or reactions are consistent with food allergy, he / she will perform allergy tests. Additional diagnostic tools for evaluation of eosinophilic or non-IgE mediated reactions include endoscopy, colonoscopy, and biopsy. Differential diagnosis Important differential diagnoses are : Lactose intolerance generally develops later in life, but can present in young patients in severe cases. It is due to an enzyme deficiency ( lactase ) and not allergy, and occurs in many non-Western people. Celiac disease is an autoimmune disorder triggered by gluten proteins such as gliadin ( present in wheat, rye, and barley ). It is a non-IgE - mediated food allergy by definition. Irritable bowel syndrome C1 Esterase inhibitor deficiency ( hereditary angioedema ), a rare disease, generally causes attacks of angioedema, but can present solely with abdominal pain and occasional diarrhea. Prevention Breastfeeding for more than four months may prevent atopic dermatitis, cow 's milk allergy, and wheezing in early childhood. Early exposure to potential allergens may be protective. Specifically, early exposure to eggs and peanuts reduces the risk of allergies to these. To avoid an allergic reaction, a strict diet can be followed. It is difficult to determine the amount of allergenic food required to elicit a reaction, so complete avoidance should be attempted. In some cases, hypersensitive reactions can be triggered by exposures to allergens through skin contact, inhalation, kissing, participation in sports, blood transfusions, cosmetics, and alcohol. Inhalation exposure Allergic reactions to airborn particles or vapors of known food allergens have been reported as an occupational consequence of people working in the food industry, but can also take place in home situations, restaurants, or confined spaces such as airplanes. According to two reviews, respiratory symptoms are common, but in some cases there has been progression to anaphylaxis. The most frequent reported cases of reactions by inhalation of allergenic foods were due to peanut, seafood, legumes, tree nut, and cow 's milk. Steam rising from cooking of lentils, green beans, chickpeas and fish has been well documented as triggering reactions, including anaphylactic reactions. One review mentioned case study examples of allergic responses to other foods, including examples in which oral consumption of the food is tolerated. Treatment The mainstay of treatment for food allergy is total avoidance of the foods identified as allergens. An allergen can enter the body by consuming a food containing the allergen, and can also be ingested by touching any surfaces that may have come into contact with the allergen, then touching the eyes or nose. For people who are extremely sensitive, avoidance includes avoiding touching or inhaling the problematic food. If the food is accidentally ingested and a systemic reaction ( anaphylaxis ) occurs, then epinephrine should be used. A second dose of epinephrine may be required for severe reactions. The person should then be transported to the emergency room, where additional treatment can be given. Other treatments include antihistamines and steroids. Epinephrine Epinephrine autoinjectors are portable single - dose epinephrine - dispensing devices used to treat anaphylaxis. Epinephrine ( adrenaline ) is the first - line treatment for severe allergic reactions ( anaphylaxis ). If administered in a timely manner, epinephrine can reverse its effects. Epinephrine relieves airway swelling and obstruction, and improves blood circulation ; blood vessels are tightened and heart rate is increased, improving circulation to body organs. Epinephrine is available by prescription in an autoinjector. Antihistamines Antihistamines can alleviate some of the milder symptoms of an allergic reaction, but do not treat all symptoms of anaphylaxis. Antihistamines block the action of histamine, which causes blood vessels to dilate and become leaky to plasma proteins. Histamine also causes itchiness by acting on sensory nerve terminals. The most common antihistamine given for food allergies is diphenhydramine. Steroids Glucocorticoid steroids are used to calm down the immune system cells that are attacked by the chemicals released during an allergic reaction. This treatment in the form of a nasal spray should not be used to treat anaphylaxis, for it only relieves symptoms in the area in which the steroid is in contact. Another reason steroids should not be used is the delay in reducing inflammation. Steroids can also be taken orally or through injection, by which every part of the body can be reached and treated, but a long time is usually needed for these to take effect. Epidemiology The most common food allergens account for about 90 % of all allergic reactions ; in adults they include shellfish, peanuts, tree nuts, fish, and egg. In children, they include milk, eggs, peanuts, and tree nuts. Six to 8 % of children under the age of three have food allergies and nearly 4 % of adults have food allergies. For reasons not entirely understood, the diagnosis of food allergies has apparently become more common in Western nations recently. In the United States, food allergy affects as many as 5 % of infants less than three years of age and 3 % to 4 % of adults. A similar prevalence is found in Canada. About 75 % of children who have allergies to milk protein are able to tolerate baked - in milk products, i.e., muffins, cookies, cake, and hydrolyzed formulas. About 50 % of children with allergies to milk, egg, soy, peanuts, tree nuts, and wheat will outgrow their allergy by the age of 6. Those who are still allergic by the age of 12 or so have less than an 8 % chance of outgrowing the allergy. Peanut and tree nut allergies are less likely to be outgrown, although evidence now shows that about 20 % of those with peanut allergies and 9 % of those with tree nut allergies will outgrow them. In Japan, allergy to buckwheat flour, used for soba noodles, is more common than peanuts, tree nuts or foods made from soy beans. United States In the United States, an estimated 12 million people have food allergies. Food allergy affects as many as 5 % of infants less than three years of age and 3 % to 4 % of adults. The prevalence of food allergies is rising. Food allergies cause roughly 30,000 emergency room visits and 150 deaths per year. Society and culture Whether rates of food allergy is increasing or not, food allergy awareness has definitely increased, with impacts on the quality of life for children, their parents and their immediate caregivers. In the United States, the Food Allergen Labeling and Consumer Protection Act of 2004 causes people to be reminded of allergy problems every time they handle a food package, and restaurants have added allergen warnings to menus. The Culinary Institute of America, a premier school for chef training, has courses in allergen - free cooking and a separate teaching kitchen. School systems have protocols about what foods can be brought into the school. Despite all these precautions, people with serious allergies are aware that accidental exposure can easily occur at other peoples ' houses, at school or in restaurants. Food fear has a significant impact on quality of life. Finally, for children with allergies, their quality of life is also affected by actions of their peers. There is an increased occurrence of bullying, which can include threats or acts of deliberately being touched with foods they need to avoid, also having their allergen - free food deliberately contaminated. Regulation of labelling In response to the risk that certain foods pose to those with food allergies, some countries have responded by instituting labeling laws that require food products to clearly inform consumers if their products contain major allergens or byproducts of major allergens. Some countries also require companies to warn customers when food has been prepared around certain allergens that have been known to cause severe reactions. An example of a list of allergens in a food item Under the U.S. Food Allergen Labeling and Consumer Protection Act of 2004 ( Public Law 108 - 282 ), companies are required to disclose on the label whether the product contains a major food allergen in clear, plain language. The eight major allergens are cow 's milk, peanuts, eggs, shellfish, fish, tree nuts, soy and wheat. The allergens have to clearly be called out in the ingredient statement. Most companies list allergens in a statement separate from the ingredient statement. The European Union requires listing for those eight plus molluscs, celery, mustard, lupin, sesame and sulfites. The EU Food Information for Consumers Regulation 1169 / 2011 -- requires food businesses to provide allergy information on food sold unpackaged, for example, in catering outlets, deli counters, bakeries and sandwich bars. On 4 January 2011, President Barack Obama signed into federal law the Food Safety and Modernization Act of 2010 ( S510 / HR2751, 111th Congress ). Section 112 of this Act establishes voluntary food allergy and anaphylaxis management guidelines for public kindergartens and elementary and secondary schools. Genetically modified food There are concerns that genetically modified foods, also described as foods sourced from genetically modified organisms ( GMO ), could be responsible for allergic reactions, and that the widespread acceptance of GMO foods may be responsible for what is a real or perceived increase in the percentage of people with allergies. One concern is that genetic engineering could make an allergy - provoking food more allergic, meaning that smaller portions would suffice to set off a reaction. Of the food currently in widespread GMO use, only soybeans are identified as a common allergen. However, for the soybean proteins known to trigger allergic reactions, there is more variation from strain to strain than between those and the GMO varieties. The same review quoted a 2016 U.S. National Academy of Sciences report that concluded, `` The committee did not find a relationship between consumption of GE foods and the increase in prevalence of food allergies. '' A second concern is that genes transferred from one species to another could introduce an allergen in a food not thought of as particularly allergenic. Research on an attempt to enhance the quality of soybean protein by adding genes from Brazil nuts was terminated when human volunteers known to have tree nut allergy reacted to the modified soybeans. A second example was the 1998 introduction of a Bacillus thuringiensis gene coding for Cry9c protein into Starlink brand corn to provide insect resistance. The U.S. Environmental Protection Agency had restricted its use to corn intended as animal feed, but in 2000 it was found in the human food supply, leading to first a voluntary and then a FDA mandated recall, referred to as the StarLink corn recall. At present, prior to a new GMO food receiving government approval, certain criteria need to be met. These include : Is the donor species known to be allergenic ? Does the amino acid sequence of the transferred proteins resemble the sequence of known allergenic proteins ? Are the transferred proteins resistant to digestion - a trait shared by many allergenic proteins ? Finally, there are requirements in some countries and recommendations in others that all foods containing GMO ingredients be so labeled, and that there be a post-launch monitoring system to report adverse effects ( much there exists in some countries for drug and dietary supplement reporting ). According to a 2015 report from the Center for Food Safety, 64 countries require labeling of GMO products in the marketplace. Research A number of desensitization techniques are being studied. Areas of research include anti-IgE antibody ( omalizumab ), specific oral tolerance induction ( SOTI, also known as OIT for oral immunotherapy ), and sublingual immunotherapy ( SLIT ). The benefits of allergen immunotherapy for food allergies is unclear, thus is not recommended as of 2015. There is research on the effects of increasing intake of polyunsaturated fatty acids ( PUFAs ) during pregnancy, lactation, via infant formula and in early childhood on the subsequent risk of developing food allergies during infancy and childhood. From two reviews, maternal intake of omega - 3, long - chain fatty acids during pregnancy appeared to reduce the risks of medically diagnosed IgE - mediated allergy, eczema and food allergy per parental reporting in the first 12 months of life, but the effects were not all sustained past 12 months. The reviews characterized the literature 's evidence as inconsistent and limited. Results when breastfeeding mothers were consuming a diet high in PUFAs were inconclusive. For infants, supplementing their diet with oils high in PUFAs did not affect the risks of food allergies, eczema or asthma either as infants or into childhood. There is research on probiotics, prebiotics and the combination of the two ( synbiotics ) as a means of treating or preventing infant and child allergies. From reviews, there appears to be a treatment benefit for eczema, but not asthma, wheezing or rhinoconjunctivitis. The evidence was not consistent for preventing food allergies and this approach can not yet be recommended. See also List of allergens ( food and non-food ) SEICAP ( Spanish Society of Pediatric Allergy, Asthma and Clinical Immunology ) References ^ Jump up to : National Institute of Allergy and Infectious Diseases ( July 2012 ). `` Food Allergy An Overview '' ( PDF ). Archived from the original ( pdf ) on 2016 - 03 - 05. ^ Jump up to : Sicherer, SH. ; Sampson, HA. ( Feb 2014 ). `` Food allergy : Epidemiology, pathogenesis, diagnosis, and treatment ''. J Allergy Clin Immunol. 133 ( 2 ) : 291 -- 307 ; quiz 308. doi : 10.1016 / j. jaci. 2013.11. 020. PMID 24388012. ^ Jump up to : Ierodiakonou, D ; Garcia - Larsen, V ; Logan, A ; Groome, A ; Cunha, S ; Chivinge, J ; Robinson, Z ; Geoghegan, N ; Jarrold, K ; Reeves, T ; Tagiyeva - Milne, N ; Nurmatov, U ; Trivella, M ; Leonardi - Bee, J ; Boyle, RJ ( 20 September 2016 ). `` Timing of Allergenic Food Introduction to the Infant Diet and Risk of Allergic or Autoimmune Disease : A Systematic Review and Meta - analysis ''. JAMA. 316 ( 11 ) : 1181 -- 1192. doi : 10.1001 / jama. 2016.12623. PMID 27654604. Jump up ^ Nowak - Węgrzyn, A ; Katz, Y ; Mehr, SS ; Koletzko, S ( May 2015 ). `` Non-IgE - mediated gastrointestinal food allergy ''. The Journal of Allergy and Clinical Immunology. 135 ( 5 ) : 1114 -- 24. doi : 10.1016 / j. jaci. 2015.03. 025. PMID 25956013. ^ Jump up to : `` Allergen Immunotherapy ''. April 22, 2015. Archived from the original on 17 June 2015. Retrieved 15 June 2015. Jump up ^ `` Making sense of allergies '' ( PDF ). Sense About Science. p. 1. Archived ( PDF ) from the original on 18 June 2015. Retrieved 7 June 2015. Jump up ^ Coon, ER. ; Quinonez, RA. ; Moyer, VA. ; Schroeder, AR. ( Nov 2014 ). `` Overdiagnosis : how our compulsion for diagnosis may be harming children ''. Pediatrics. 134 ( 5 ) : 1013 -- 23. doi : 10.1542 / peds. 2014 - 1778. PMID 25287462. Jump up ^ Ferreira, CT. ; Seidman, E. `` Food allergy : a practical update from the gastroenterological viewpoint ''. J Pediatr ( Rio J ). 83 ( 1 ) : 7 -- 20. doi : 10.2223 / JPED. 1587. PMID 17279290. ^ Jump up to : MedlinePlus Encyclopedia Food allergy Jump up ^ van Ree 1 Jump up ^ Sicherer 2006, p. 12 Jump up ^ Food Allergies Archived 2008 - 09 - 14 at the Wayback Machine... Food Allergy Initiative. 2009. Accessed 27 Mar 2010. Jump up ^ `` Food Allergy Facts & Figures ''. Asthma and Allergy Foundation of America. March 28, 2007. Archived from the original on December 7, 2006. Jump up ^ `` Food allergy and intolerance ''. Allergy & Intolerance. Food Additives and Ingredients Association. Archived from the original on 2011 - 02 - 13. Retrieved 2010 - 06 - 08. Jump up ^ `` About Food Allergies ''. Food Allergy Initiative. 2008. Archived from the original on 2008 - 12 - 12. Retrieved 2008 - 12 - 08. Jump up ^ `` Rice Allergy ''. HealthCentersOnline. 2006. p. 2. Archived from the original on 2006 - 05 - 23. Retrieved 2006 - 10 - 26. Jump up ^ Sicherer 2006, p. 62 ^ Jump up to : Sicherer 2006, p. 63 Jump up ^ Savage JH, Matsui EC, Skripak JM, Wood RA ( December 2007 ). `` The natural history of egg allergy ''. J Allergy Clin Immunol. 120 ( 6 ) : 1413 -- 7. doi : 10.1016 / j. jaci. 2007.09. 040. PMID 18073126. Jump up ^ Sicherer 2006, p. 64 Jump up ^ `` Seafood ( Fish, Crustaceans and Shellfish ) - Priority food allergens ''. Health Canada, Health Products and Food Branch, Food Directorate, Bureau of Chemical Safety, Food Research Division. 2012. Archived from the original on 20 November 2016. Retrieved 19 November 2016. Jump up ^ Gottfried Schmalz ; Dorthe Arenholt Bindslev ( 2008 ). Biocompatibility of Dental Materials. Springer. Archived from the original on May 18, 2016. Retrieved March 5, 2014. Jump up ^ Thomas P. Habif ( 2009 ). Clinical Dermatology. Elsevier Health Sciences. Archived from the original on September 8, 2017. Retrieved March 6, 2014. Jump up ^ Edward T. Bope ; Rick D. Kellerman ( 2013 ). Conn 's Current Therapy 2014 : Expert Consult. Elsevier Health Sciences. Archived from the original on May 5, 2016. Retrieved March 6, 2014. Jump up ^ Clayton, Ellen ( 2012 ). Adverse Effects of Vaccines : Evidence and Causality. Institute of Medicine. p. 65. ISBN 978 - 0 - 309 - 21435 - 3. Jump up ^ `` Other atopic dermatitis and related conditions ''. ICD9. Archived from the original on 2007 - 09 - 30. Jump up ^ `` Policy Statement : Hypoallergenic Infant Formulas ''. American Academy of Pediatrics. August 2, 2000. Archived from the original on January 16, 2008. Jump up ^ `` Other Common Allergens ''. Food Allergy Research & Education. Archived from the original on 2014 - 06 - 16. Jump up ^ `` Food allergy ''. NHS Choices. 16 May 2016. Retrieved 31 January 2017. A food allergy is when the body 's immune system reacts unusually to specific foods Jump up ^ Food Reactions. Allergies Archived 2010 - 04 - 16 at the Wayback Machine... Foodreactions.org. Kent, England. 2005. Accessed 27 Apr 2010. Jump up ^ Nester 2009, p. 414 Jump up ^ Mayo Clinic. Causes of Food Allergies. Archived 2010 - 02 - 27 at the Wayback Machine. April 2010. ^ Jump up to : Janeway, Charles ; Paul Travers ; Mark Walport ; Mark Shlomchik ( 2001 ). Immunobiology ; Fifth Edition. New York and London : Garland Science. pp. e -- book. ISBN 0 - 8153 - 4101 - 6. Archived from the original on 2009 - 06 - 28. Jump up ^ Grimbaldeston MA, Metz M, Yu M, Tsai M, Galli SJ ( 2006 ). `` Effector and potential immunoregulatory roles of mast cells in IgE - associated acquired immune responses ''. Curr. Opin. Immunol. 18 ( 6 ) : 751 -- 60. doi : 10.1016 / j. coi. 2006.09. 011. PMID 17011762. Jump up ^ Holt PG, Sly PD ( 2007 ). `` Th2 cytokines in the asthma late - phase response ''. Lancet. 370 ( 9596 ) : 1396 -- 8. doi : 10.1016 / S0140 - 6736 ( 07 ) 61587 - 6. PMID 17950849. Jump up ^ Sicherer 2006, p. 185 Jump up ^ `` Allergies and EGIDs American Partnership For Eosinophilic Disorders ''. Apfed.org. Retrieved 2014 - 03 - 31. Jump up ^ `` Patch test in the diagnosis of food allergy ''. 2014 - 03 - 22. Archived from the original on 2014 - 03 - 10. Retrieved 2014 - 03 - 31. Jump up ^ Rokaite R, Labanauskas L, Vaideliene L ( 2014 - 01 - 24 ). `` Role of the skin patch test in diagnosing food allergy in children with atopic dermatitis ''. Medicina ( Kaunas ). 40 : 1081 -- 7. PMID 15547309. Jump up ^ Sicherer 2006, pp. 187 -- 8 Jump up ^ `` What is a RAST test ? What is a CAP - RAST test ? ''. kidswithfoodallergies.org. Archived from the original on 2013 - 05 - 11. Jump up ^ Sampson, HA ; Ho DG ( October 1997 ). `` Relationship between food - specific IgE concentrations and the risk of positive food challenges in children and adolescents ''. J Allergy Clin Immunol. 100 ( 4 ) : 444 -- 51. doi : 10.1016 / S0091 - 6749 ( 97 ) 70133 - 7. PMID 9338535. Jump up ^ Sampson, HA ( May 2001 ). `` Utility of food - specific IgE concentrations in predicting symptomatic food allergy ''. J Allergy Clin Immunol. 107 ( 5 ) : 891 -- 6. doi : 10.1067 / mai. 2001.114708. PMID 11344358. Jump up ^ Garcia - Ara, C ; Boyano - Martinez T ; Diaz - Pena JM ; et al. ( January 2001 ). `` Specific IgE levels in the diagnosis of immediate hypersensitivity to cows ' milk protein in the infant ''. Allergy Clin Immunol. 107 ( 1 ) : 185 -- 90. doi : 10.1067 / mai. 2001.111592. PMID 11150010. Jump up ^ Wüthrich B ( 2005 ). `` Unproven techniques in allergy diagnosis ''. J Investig Allergol Clin Immunol. 15 ( 2 ) : 86 -- 90. PMID 16047707. Jump up ^ Sicherer 2006, p. 189 Jump up ^ Greer, FR. ; Sicherer, SH. ; Burks, AW. ( Jan 2008 ). `` Effects of early nutritional interventions on the development of atopic disease in infants and children : the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas ''. Pediatrics. 121 ( 1 ) : 183 -- 91. doi : 10.1542 / peds. 2007 - 3022. PMID 18166574. Jump up ^ Sicherer 2006, pp. 151 -- 8 ^ Jump up to : Leonardi S, Pecoraro R, Filippelli M, Miraglia del Giudice M, Marseglia G, Salpietro C, Arrigo T, Stringari G, Ricò S, La Rosa M, Caffarelli C ( 2014 ). `` Allergic reactions to foods by inhalation in children ''. Allergy Asthma Proc. 35 ( 4 ) : 288 -- 294. doi : 10.2500 / aap. 2014.35. 3755. PMID 24992548. Jump up ^ James JM, Crespo JF ( 2007 ). `` Allergic reactions to foods by inhalation ''. Curr Allergy Asthma Rep. 7 ( 3 ) : 167 -- 174. PMID 17448326. Jump up ^ Vitaliti G, Pavone P, Spataro G, Giunta L, Guglielmo F, Falsaperla R ( 2015 ). `` Legumes steam allergy in childhood : Update of the reported cases ''. Allergol Immunopathol ( Madr ). 43 ( 2 ) : 196 -- 202. doi : 10.1016 / j. aller. 2013.09. 009. PMID 24411097. Jump up ^ `` European Food Allergy and Anaphalaxis Public Declaration ''. the European Academy of Allergy and Clinical Immunology ( EAACI ). Archived from the original on 15 December 2013. Retrieved 10 December 2013. Jump up ^ Sicherer 2006, p. 133 Jump up ^ Sicherer 2006, p. 131 Jump up ^ Sicherer 2006, p. 134 Jump up ^ `` About Food Allergies - > Allergens ''. Food Allergy Initiative. Archived from the original on 2013 - 12 - 09. Retrieved 11 Dec 2013. ^ Jump up to : National Institute of Allergy and Infectious Diseases ( July 2004 ). `` Food Allergy : An Overview '' ( PDF ). National Institutes of Health. p. 35. Archived from the original ( PDF ) on 2016 - 03 - 05. ^ Jump up to : Kagan RS ( February 2003 ). `` Food allergy : an overview ''. Environ Health Perspect. 111 ( 2 ) : 223 -- 5. doi : 10.1289 / ehp. 5702. PMC 1241355. PMID 12573910. ^ Jump up to : Sampson H ( 2004 ). `` Update on food allergy ''. J Allergy Clin Immunol. 113 ( 5 ) : 805 -- 819. doi : 10.1016 / j. jaci. 2004.03. 014. PMID 15131561. ^ Jump up to : Sicherer S, Sampson H ( 2006 ). `` 9. Food allergy ''. J Allergy Clin Immunol. 117 ( 2 Suppl Mini -- Primer ) : S470 -- 5. doi : 10.1016 / j. jaci. 2005.05. 048. PMID 16455349. Jump up ^ `` Food Allergies and Intolerance ''. Health Canada. December 6, 2007. Archived from the original on June 14, 2007. Jump up ^ Lucendo AJ, Arias A, Gonzalez - Cervera J, Mota - Huertas T, Yague - Compadre JL. Tolerance of a cow 's milk - based hydrolyzed formula in patients with eosinophilic esophagitis triggered by milk. Allergy ; 68 : 1065 -- 72. Link Archived 2016 - 11 - 28 at the Wayback Machine. Jump up ^ `` What Are Food Allergies ? Food Allergy Summary ''. Asthma and Allergy Foundation of America. March 28, 2007. Archived from the original on October 27, 2007. Jump up ^ `` Outgrowing food allergies ''. Children 's Memorial Hospital. Archived from the original on 2007 - 10 - 20. Jump up ^ Fleischer DM, Conover - Walker MK, Matsui EC, Wood RA ( November 2005 ). `` The natural history of tree nut allergy ''. J Allergy Clin Immunol. 116 ( 5 ) : 1087 -- 93. doi : 10.1016 / j. jaci. 2005.09. 002. PMID 16275381. Jump up ^ Urisu A, Ebisawa M, Ito K, Aihara Y, Ito S, Mayumi M, Kohno Y, Kondo N ( 2014 ). `` Japanese Guideline for Food Allergy 2014 ''. Allergol Int. 63 ( 3 ) : 399 -- 419. doi : 10.2332 / allergolint. 14 - RAI - 0770. PMID 25178179. Jump up ^ `` Food Allergy Media Q&A '' ( PDF ). Food Allergy & Anaphylaxis Network. 2010 - 05 - 26. Archived ( PDF ) from the original on 2010 - 12 - 30. Retrieved 2011 - 03 - 25. Jump up ^ Branum AM, Lukacs SL ( 2008 ). `` Food allergy among U.S. children : trends in prevalence and hospitalizations ''. NCHS Data Brief ( 10 ) : 1 -- 8. PMID 19389315. Jump up ^ Ben - Shoshan M, Turnbull E, Clarke A ( 2012 ). `` Food allergy : temporal trends and determinants ''. Curr Allergy Asthma Rep. 12 ( 4 ) : 346 -- 72. doi : 10.1007 / s11882 - 012 - 0274 - 3. PMID 22723032. Jump up ^ Question 6 : How serious are food allergies ? Food Allergen Labeling And Consumer Protection Act of 2004 Questions and Answers, U.S. Food and Drug Administration ( 2006 ). Jump up ^ Ravid NL, Annunziato RA, Ambrose MA, Chuang K, Mullarkey C, Sicherer SH, Shemesh E, Cox AL ( 2015 ). `` Mental health and quality - of - life concerns related to the burden of food allergy ''. Psychiatr. Clin. North Am. 38 ( 1 ) : 77 -- 89. doi : 10.1016 / j. psc. 2014.11. 004. PMID 25725570. Jump up ^ Morou Z, Tatsioni A, Dimoliatis ID, Papadopoulos NG ( 2014 ). `` Health - related quality of life in children with food allergy and their parents : a systematic review of the literature ''. J Investig Allergol Clin Immunol. 24 ( 6 ) : 382 -- 95. PMID 25668890. ^ Jump up to : Lange L ( 2014 ). `` Quality of life in the setting of anaphylaxis and food allergy ''. Allergo J Int. 23 ( 7 ) : 252 -- 260. doi : 10.1007 / s40629 - 014 - 0029 - x. PMC 4479473. PMID 26120535. ^ Jump up to : van der Velde JL, Dubois AE, Flokstra - de Blok BM ( 2013 ). `` Food allergy and quality of life : what have we learned ? ''. Curr Allergy Asthma Rep. 13 ( 6 ) : 651 -- 61. doi : 10.1007 / s11882 - 013 - 0391 - 7. PMID 24122150. Jump up ^ Culinary Institute of America Allergen - free dining oasis comes to the CIA ( 2017 ) Jump up ^ Shah E, Pongracic J ( 2008 ). `` Food - induced anaphylaxis : who, what, why, and where ? ''. Pediatr Ann. 37 ( 8 ) : 536 -- 41. PMID 18751571. Jump up ^ Fong AT, Katelaris CH, Wainstein B ( 2017 ). `` Bullying and quality of life in children and adolescents with food allergy ''. J Paediatr Child Health. 53 ( 7 ) : 630 -- 635. doi : 10.1111 / jpc. 13570. PMID 28608485. Jump up ^ Allen KJ, Turner PJ, Pawankar R, Taylor S, Sicherer S, Lack G, Rosario N, Ebisawa M, Wong G, Mills EN, Beyer K, Fiocchi A, Sampson HA ( 2014 ). `` Precautionary labelling of foods for allergen content : are we ready for a global framework ? ''. World Allergy Organ J. 7 ( 1 ) : 10. doi : 10.1186 / 1939 - 4551 - 7 - 10. PMC 4005619. PMID 24791183. Jump up ^ `` Food Allergen Labeling and Consumer Protection Act of 2004 ''. FDA. August 2, 2004. Archived from the original on 2011 - 02 - 02. Jump up ^ `` Food allergen labelling and information requirements under the EU Food Information for Consumers Regulation No. 1169 / 2011 : Technical Guidance '' ( April 2015 ). Jump up ^ `` Archived copy ''. Archived from the original on 2014 - 12 - 08. Retrieved 2014 - 12 - 12. ^ Jump up to : Lee TH, Ho HK, Leung TF ( 2017 ). `` Genetically modified foods and allergy ''. Hong Kong Med J. 23 ( 3 ) : 291 -- 5. doi : 10.12809 / hkmj166189. PMID 28473652. ^ Jump up to : Dunn SE, Vicini JL, Glenn KC, Fleischer DM, Greenhawt MJ ( 2017 ). `` The allergenicity of genetically modified foods from genetically engineered crops : A narrative and systematic review ''. Ann. Allergy Asthma Immunol. 119 ( 3 ) : 214 -- 222. e3. doi : 10.1016 / j. anai. 2017.07. 010. PMID 28890018. ^ Jump up to : Selb R, Wal JM, Moreno FJ, Lovik M, Mills C, Hoffmann - Sommergruber K, Fernandez A ( 2017 ). `` Assessment of endogenous allergenicity of genetically modified plants exemplified by soybean - Where do we stand ? ''. Food Chem. Toxicol. 101 : 139 -- 148. doi : 10.1016 / j. fct. 2017.01. 014. PMID 28111299. Jump up ^ Bucchini L, Goldman LR ( 2002 ). `` Starlink corn : a risk analysis ''. Environ. Health Perspect. 110 ( 1 ) : 5 -- 13. PMC 1240687. PMID 11781159. Jump up ^ `` International Labeling Laws ''. Center for Food Safety. Jump up ^ Nowak - Węgrzyn A, Sampson HA ( March 2011 ). `` Future therapies for food allergies ''. J. Allergy Clin. Immunol. 127 ( 3 ) : 558 -- 73 ; quiz 574 -- 5. doi : 10.1016 / j. jaci. 2010.12. 1098. PMC 3066474. PMID 21277625. ^ Jump up to : Best KP, Gold M, Kennedy D, Martin J, Makrides M ( 2016 ). `` Omega - 3 long - chain PUFA intake during pregnancy and allergic disease outcomes in the offspring : a systematic review and meta - analysis of observational studies and randomized controlled trials ''. Am. J. Clin. Nutr. 103 ( 1 ) : 128 -- 143. doi : 10.3945 / ajcn. 115.111104. PMID 26675770. ^ Jump up to : Gunaratne AW, Makrides M, Collins CT ( 2015 ). `` Maternal prenatal and / or postnatal n - 3 long chain polyunsaturated fatty acids ( LCPUFA ) supplementation for preventing allergies in early childhood ''. Cochrane Database Syst Rev ( 7 ) : CD010085. doi : 10.1002 / 14651858. CD010085. pub2. PMID 26197477. Jump up ^ Waidyatillake NT, Dharmage SC, Allen KJ, Lodge CJ, Simpson JA, Bowatte G, Abramson MJ, Lowe AJ ( 2018 ). `` Association of breast milk fatty acids with allergic disease outcomes - A systematic review ''. Allergy. 73 ( 2 ) : 295 -- 312. doi : 10.1111 / all. 13300. PMID 28869762. Jump up ^ Schindler, Tim ; Sinn, John Kh ; Osborn, David A. ( 2016 - 10 - 28 ). `` Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy ''. The Cochrane Database of Systematic Reviews. 10 : CD010112. doi : 10.1002 / 14651858. CD010112. pub2. ISSN 1469 - 493X. PMID 27788565. Jump up ^ Chang YS, Trivedi MK, Jha A, Lin YF, Dimaano L, García - Romero MT ( 2016 ). `` Synbiotics for Prevention and Treatment of Atopic Dermatitis : A Meta - analysis of Randomized Clinical Trials ''. JAMA Pediatr. 170 ( 3 ) : 236 -- 242. doi : 10.1001 / jamapediatrics. 2015.3943. PMID 26810481. ^ Jump up to : Cuello - Garcia CA, Brożek JL, Fiocchi A, Pawankar R, Yepes - Nuñez JJ, Terracciano L, Gandhi S, Agarwal A, Zhang Y, Schünemann HJ ( 2015 ). `` Probiotics for the prevention of allergy : A systematic review and meta - analysis of randomized controlled trials ''. J. Allergy Clin. Immunol. 136 ( 4 ) : 952 -- 961. doi : 10.1016 / j. jaci. 2015.04. 031. PMID 26044853. ^ Jump up to : Osborn DA, Sinn JK ( 2013 ). `` Prebiotics in infants for prevention of allergy ''. Cochrane Database Syst Rev ( 3 ) : CD006474. doi : 10.1002 / 14651858. CD006474. pub3. PMID 23543544. Jump up ^ Zuccotti G, Meneghin F, Aceti A, Barone G, Callegari ML, Di Mauro A, Fantini MP, Gori D, Indrio F, Maggio L, Morelli L, Corvaglia L ( 2015 ). `` Probiotics for prevention of atopic diseases in infants : systematic review and meta - analysis ''. Allergy. 70 ( 11 ) : 1356 -- 1371. doi : 10.1111 / all. 12700. PMID 26198702. Jump up ^ Zhang GQ, Hu HJ, Liu CY, Zhang Q, Shakya S, Li ZY ( 2016 ). `` Probiotics for Prevention of Atopy and Food Hypersensitivity in Early Childhood : A PRISMA - Compliant Systematic Review and Meta - Analysis of Randomized Controlled Trials ''. Medicine ( Baltimore ). 95 ( 8 ) : e2562. doi : 10.1097 / MD. 0000000000002562. PMC 4778993. PMID 26937896. Jump up ^ de Silva D, Geromi M, Panesar SS, Muraro A, Werfel T, Hoffmann - Sommergruber K, Roberts G, Cardona V, Dubois AE, Halken S, Host A, Poulsen LK, Van Ree R, Vlieg - Boerstra BJ, Agache I, Sheikh A ( 2014 ). `` Acute and long - term management of food allergy : systematic review ''. Allergy. 69 ( 2 ) : 159 -- 167. doi : 10.1111 / all. 12314. PMID 24215577. Notes Nester, Eugene W. ; Anderson, Denise G. ; Roberts Jr, C. Evans ; Nester, Martha T. ( 2009 ). `` Immunologic Disorders ''. Microbiology : A Human Perspective ( 6th ed. ). New York : McGraw - Hill. pp. 414 -- 428. Sicherer, Scott H. ( 2006 ). Understanding and Managing Your Child 's Food Allergy. Baltimore : Johns Hopkins University Press. External links Classification V T D ICD - 10 : T78. 0 ICD - 9 - CM : V15. 01 - V15. 05 OMIM : 147050 MeSH : D005512 External resources MedlinePlus : 000817 eMedicine : med / 806 Food Allergy, Merck Manual `` Food Allergies and Intolerances Resource List for Consumers '' ( PDF ). Food and Nutrition Information Center, National Agricultural Library. December 2010. -- a collection of resources on the topic of food allergies and intolerances Food science General Allergy Engineering Microbiology Nutrition Diet clinical Processing Processing aids Quality Sensory analysis Discrimination testing Rheology Storage Technology Food chemistry Additives Carbohydrates Coloring Enzymes Essential fatty acids Flavors Fortification Lipids `` Minerals '' ( Chemical elements ) Proteins Vitamins Water Food preservation Biopreservation Canning Cold chain Curing Drying Fermentation Freeze - drying Freezing Hurdle technology Irradiation Jamming Jellying Jugging Modified atmosphere Pascalization Pickling Potting Confit Potjevleesch Salting Smoking Sugaring Tyndallization Vacuum packing Food industry Manufacturing Packaging Marketing Foodservice Fortification Food safety Adulterants, food contaminants 3 - MCPD Aldicarb Cyanide Formaldehyde Lead poisoning Melamine Mercury in fish Sudan I Flavorings Monosodium glutamate ( MSG ) Salt Sugar High - fructose corn syrup Microorganisms Botulism Campylobacter jejuni Clostridium perfringens Escherichia coli O104 : H4 Escherichia coli O157 : H7 Hepatitis A Hepatitis E Listeria Norovirus Rotavirus Salmonella Parasitic infections through food Amoebiasis Anisakiasis Cryptosporidiosis Cyclosporiasis Diphyllobothriasis Enterobiasis Fasciolopsiasis Fasciolosis Giardiasis Gnathostomiasis Paragonimiasis Toxoplasmosis Trichinosis Trichuriasis Pesticides Chlorpyrifos DDT Lindane Malathion Methamidophos Preservatives Benzoic acid Ethylenediaminetetraacetic acid ( EDTA ) Sodium benzoate Sugar substitutes Acesulfame potassium Aspartame Saccharin Sodium cyclamate Sorbitol Sucralose Toxins, poisons, environment pollution Aflatoxin Arsenic contamination of groundwater Benzene in soft drinks Bisphenol A Dieldrin Diethylstilbestrol Dioxin Mycotoxins Nonylphenol Shellfish poisoning Food contamination incidents Devon colic 1858 Bradford sweets poisoning 1989 Chilean grape scare 1993 Jack in the Box E. coli outbreak 1996 Odwalla E. coli outbreak 1999 Sun Orchard salmonellosis outbreak 2005 Indonesia food scare 2006 North American E. coli O157 : H7 outbreaks 2007 Vietnam food scare 2008 Canada listeriosis outbreak 2008 Chinese milk scandal 2008 Irish pork crisis 2008 United States salmonellosis outbreak 2011 Germany E. coli O104 : H4 outbreak 2011 Taiwan food scandal 2011 United States listeriosis outbreak 2013 European aflatoxin contamination 2013 horse meat scandal 2013 Taiwan food scandal 2014 Taiwan food scandal 2015 United States E. coli outbreak 2017 Brazil weak meat scandal Food safety incidents in China Foodborne illness outbreaks death toll United States ICA meat repackaging controversy Minamata disease StarLink corn recall Toxic oil syndrome Regulation, standards, watchdogs Acceptable daily intake E number Food labeling regulations Food libel laws International Food Safety Network ISO 22000 Quality Assurance International Institutions Centre for Food Safety European Food Safety Authority Institute for Food Safety and Health International Food Safety Network Ministry of Food and Drug Safety Food substitutes Artificial fat substitutes Olestra Trans fat Artificial protein substitutes Acid - hydrolyzed vegetable protein Artificial sugar substitutes Acesulfame potassium Alitame Aspartame Aspartame - acesulfame salt Dulcin Glucin Hydrogenated starch hydrolysates Neohesperidin dihydrochalcone Neotame NutraSweet Nutrinova Saccharin Sodium cyclamate Sucralose Natural food substitutes Cheese analogues Coffee substitutes Egg substitutes Meat analogues bacon list Milk substitutes Phyllodulcin Salt substitutes Food politics Food power Food security Famine Malnutrition Overnutrition Institutions International Association for Food Protection Food and Drug Administration Food and Agriculture Organization National Agriculture and Food Research Organization National Food and Drug Authority Allergic conditions Respiratory system Allergic rhinitis ( hay fever ) Asthma Hypersensitivity pneumonitis Eosinophilic pneumonia Eosinophilic granulomatosis with polyangiitis Allergic bronchopulmonary aspergillosis Farmer 's lung Laboratory animal allergy Skin Angioedema Urticaria Atopic dermatitis Allergic contact dermatitis Hypersensitivity vasculitis Blood and immune system Serum sickness Circulatory system Anaphylaxis Digestive system Coeliac disease Eosinophilic gastroenteritis Eosinophilic esophagitis Food allergy Egg allergy Milk intolerance Nervous system Eosinophilic meningitis Genitourinary system Acute interstitial nephritis Other conditions Drug allergy Allergic conjunctivitis Latex allergy Hypersensitivity and autoimmune diseases ( 279.5 -- 6 ) Type I / allergy / atopy ( IgE ) Foreign Atopic eczema Allergic urticaria Allergic rhinitis ( Hay fever ) Allergic asthma Anaphylaxis Food allergy common allergies include : Milk Egg Peanut Tree nut Seafood Soy Wheat Penicillin allergy Autoimmune Eosinophilic esophagitis Type II / ADCC IgM IgG Foreign Hemolytic disease of the newborn Autoimmune Cytotoxic Autoimmune hemolytic anemia Immune thrombocytopenic purpura Bullous pemphigoid Pemphigus vulgaris Rheumatic fever Goodpasture 's syndrome Guillain -- Barré syndrome `` Type V '' / receptor Graves ' disease Myasthenia gravis Pernicious anemia Type III ( Immune complex ) Foreign Henoch -- Schönlein purpura Hypersensitivity vasculitis Reactive arthritis Farmer 's lung Post-streptococcal glomerulonephritis Serum sickness Arthus reaction Autoimmune Systemic lupus erythematosus Subacute bacterial endocarditis Rheumatoid arthritis Type IV / cell - mediated ( T cells ) Foreign Allergic contact dermatitis Mantoux test Autoimmune Diabetes mellitus type 1 Hashimoto 's thyroiditis Multiple sclerosis Coeliac disease Giant - cell arteritis Postorgasmic illness syndrome Reactive arthritis GVHD Transfusion - associated graft versus host disease Unknown / multiple Foreign Hypersensitivity pneumonitis Allergic bronchopulmonary aspergillosis Transplant rejection Latex allergy ( I + IV ) Autoimmune Sjögren 's syndrome Autoimmune hepatitis Autoimmune polyendocrine syndrome APS1 APS2 Autoimmune adrenalitis Systemic autoimmune disease GND : 4034871 - 4 NDL : 01052131 Food portal Medicine portal Retrieved from `` https://en.wikipedia.org/w/index.php?title=Food_allergy&oldid=821601770 '' Categories : Food allergies Hidden categories : Webarchive template wayback links Infobox medical condition ( new ) All articles with unsourced statements Articles with unsourced statements from November 2016 Pages containing citation needed template with deprecated parameters Articles with unsourced statements from November 2014 Articles with unsourced statements from February 2007 Wikipedia articles with GND identifiers RTT RTTEM Talk Contents About Wikipedia Беларуская ( тарашкевіца ) ‎ Català Čeština Deutsch Ελληνικά Español فارسی Français Gaeilge Galego 한국어 Hrvatski Íslenska Italiano עברית Bahasa Melayu Nederlands 日本 語 Norsk ଓଡ଼ିଆ Polski Português Русский සිංහල Slovenščina Srpskohrvatski / српскохрватски Svenska ไทย Українська 中文 Edit links This page was last edited on 21 January 2018, at 13 : 56. 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Question: food allergies are autoimmune responses to which specific type of nutrient
Answer: protein