Zinc - wikipedia Zinc This article is about the metallic element. For other uses, see Zinc ( disambiguation ). chemical element with atomic number 30 Zinc, Zn General properties Appearance silver - gray Standard atomic weight ( A ) 7001653800000000000 ♠ 65.38 ( 2 ) Zinc in the periodic table Hydrogen Helium Lithium Beryllium Boron Carbon Nitrogen Oxygen Fluorine Neon Sodium Magnesium Aluminium Silicon Phosphorus Sulfur Chlorine Argon Potassium Calcium Scandium Titanium Vanadium Chromium Manganese Iron Cobalt Nickel Copper Zinc Gallium Germanium Arsenic Selenium Bromine Krypton Rubidium Strontium Yttrium Zirconium Niobium Molybdenum Technetium Ruthenium Rhodium Palladium Silver Cadmium Indium Tin Antimony Tellurium Iodine Xenon Caesium Barium Lanthanum Cerium Praseodymium Neodymium Promethium Samarium Europium Gadolinium Terbium Dysprosium Holmium Erbium Thulium Ytterbium Lutetium Hafnium Tantalum Tungsten Rhenium Osmium Iridium Platinum Gold Mercury ( element ) Thallium Lead Bismuth Polonium Astatine Radon Francium Radium Actinium Thorium Protactinium Uranium Neptunium Plutonium Americium Curium Berkelium Californium Einsteinium Fermium Mendelevium Nobelium Lawrencium Rutherfordium Dubnium Seaborgium Bohrium Hassium Meitnerium Darmstadtium Roentgenium Copernicium Nihonium Flerovium Moscovium Livermorium Tennessine Oganesson -- ↑ Zn ↓ Cd copper ← zinc → gallium Atomic number ( Z ) 30 Group group 12 Period period 4 Element category post-transition metal, alternatively considered a transition metal Block d - block Electron configuration ( Ar ) 3d 4s Electrons per shell 2, 8, 18, 2 Physical properties Phase at STP solid Melting point 692.68 K ​ ( 419.53 ° C, ​ 787.15 ° F ) Boiling point 1180 K ​ ( 907 ° C, ​ 1665 ° F ) Density ( near r.t. ) 7.14 g / cm when liquid ( at m.p. ) 6.57 g / cm Heat of fusion 7.32 kJ / mol Heat of vaporization 115 kJ / mol Molar heat capacity 25.470 J / ( mol K ) Vapor pressure P ( Pa ) 10 100 1 k 10 k 100 k at T ( K ) 610 670 750 852 990 1179 Atomic properties Oxidation states - 2, 0, + 1, + 2 ​ ( an amphoteric oxide ) Electronegativity Pauling scale : 1.65 Ionization energies 1st : 906.4 kJ / mol 2nd : 1733.3 kJ / mol 3rd : 3833 kJ / mol ( more ) Atomic radius empirical : 134 pm Covalent radius 122 ± 4 pm Van der Waals radius 139 pm Spectral lines Miscellanea Crystal structure ​ hexagonal close - packed ( hcp ) Speed of sound thin rod 3850 m / s ( at r.t. ) ( rolled ) Thermal expansion 30.2 μm / ( m K ) ( at 25 ° C ) Thermal conductivity 116 W / ( m K ) Electrical resistivity 59.0 nΩ m ( at 20 ° C ) Magnetic ordering diamagnetic Magnetic susceptibility − 11.4 10 cm / mol ( 298 K ) Young 's modulus 108 GPa Shear modulus 43 GPa Bulk modulus 70 GPa Poisson ratio 0.25 Mohs hardness 2.5 Brinell hardness 327 -- 412 MPa CAS Number 7440 - 66 - 6 History Discovery Indian metallurgists ( before 1000 BCE ) First isolation Andreas Sigismund Marggraf ( 1746 ) Recognized as a unique metal by Rasaratna Samuccaya ( 800 ) Main isotopes of zinc Isotope Abundance Half - life ( t ) Decay mode Product Zn 49.2 % stable Zn syn 244 d ε Cu γ -- Zn 27.7 % stable Zn 4.0 % stable Zn 18.5 % stable Zn syn 56 min β Ga Zn syn 13.8 h β Ga Zn 0.6 % stable Zn syn 2.4 min β Ga Zn syn 4 d β Ga Zn syn 46.5 h β Ga view talk references in Wikidata Zinc is a chemical element with symbol Zn and atomic number 30. It is the first element in group 12 of the periodic table. In some respects zinc is chemically similar to magnesium : both elements exhibit only one normal oxidation state ( + 2 ), and the Zn and Mg ions are of similar size. Zinc is the 24th most abundant element in Earth 's crust and has five stable isotopes. The most common zinc ore is sphalerite ( zinc blende ), a zinc sulfide mineral. The largest workable lodes are in Australia, Asia, and the United States. Zinc is refined by froth flotation of the ore, roasting, and final extraction using electricity ( electrowinning ). Brass, an alloy of copper and zinc in various proportions, was used as early as the third millennium BC in the Aegean, Iraq, the United Arab Emirates, Kalmykia, Turkmenistan and Georgia, and the second millennium BC in West India, Uzbekistan, Iran, Syria, Iraq, and Israel ( Judea ). Zinc metal was not produced on a large scale until the 12th century in India, though it was known to the ancient Romans and Greeks. The mines of Rajasthan have given definite evidence of zinc production going back to the 6th century BC. To date, the oldest evidence of pure zinc comes from Zawar, in Rajasthan, as early as the 9th century AD when a distillation process was employed to make pure zinc. Alchemists burned zinc in air to form what they called `` philosopher 's wool '' or `` white snow ''. The element was probably named by the alchemist Paracelsus after the German word Zinke ( prong, tooth ). German chemist Andreas Sigismund Marggraf is credited with discovering pure metallic zinc in 1746. Work by Luigi Galvani and Alessandro Volta uncovered the electrochemical properties of zinc by 1800. Corrosion - resistant zinc plating of iron ( hot - dip galvanizing ) is the major application for zinc. Other applications are in electrical batteries, small non-structural castings, and alloys such as brass. A variety of zinc compounds are commonly used, such as zinc carbonate and zinc gluconate ( as dietary supplements ), zinc chloride ( in deodorants ), zinc pyrithione ( anti-dandruff shampoos ), zinc sulfide ( in luminescent paints ), and zinc methyl or zinc diethyl in the organic laboratory. Zinc is an essential mineral, including to prenatal and postnatal development. Zinc deficiency affects about two billion people in the developing world and is associated with many diseases. In children, deficiency causes growth retardation, delayed sexual maturation, infection susceptibility, and diarrhea. Enzymes with a zinc atom in the reactive center are widespread in biochemistry, such as alcohol dehydrogenase in humans. Consumption of excess zinc can cause ataxia, lethargy and copper deficiency. Contents 1 Characteristics 1.1 Physical properties 1.2 Occurrence 1.3 Isotopes 2 Compounds and chemistry 2.1 Reactivity 2.2 Zinc ( I ) compounds 2.3 Zinc ( II ) compounds 2.4 Test for zinc 3 History 3.1 Ancient use 3.2 Early studies and naming 3.3 Isolation 3.4 Later work 4 Production 4.1 Mining and processing 4.2 Environmental impact 5 Applications 5.1 Anti-corrosion and batteries 5.2 Alloys 5.3 Other industrial uses 5.4 Organic chemistry 5.5 Dietary supplement 5.5. 1 Common cold 5.6 Topical use 6 Biological role 6.1 Enzymes 6.2 Signalling 6.3 Other proteins 6.4 Dietary recommendations 6.5 Dietary intake 6.6 Deficiency 6.7 Soil remediation 6.8 Agriculture 7 Precautions 7.1 Toxicity 7.2 Poisoning 8 See also 9 Notes 10 References 11 Bibliography 12 External links Characteristics Physical properties Zinc is a bluish - white, lustrous, diamagnetic metal, though most common commercial grades of the metal have a dull finish. It is somewhat less dense than iron and has a hexagonal crystal structure, with a distorted form of hexagonal close packing, in which each atom has six nearest neighbors ( at 265.9 pm ) in its own plane and six others at a greater distance of 290.6 pm. The metal is hard and brittle at most temperatures but becomes malleable between 100 and 150 ° C. Above 210 ° C, the metal becomes brittle again and can be pulverized by beating. Zinc is a fair conductor of electricity. For a metal, zinc has relatively low melting ( 419.5 ° C ) and boiling points ( 907 ° C ). The melting point is the lowest of all the d - block metals aside from mercury and cadmium ; for this, among other reasons, zinc, cadmium, and mercury are often not considered to be transition metals like the rest of the d - block metals are. Many alloys contain zinc, including brass. Other metals long known to form binary alloys with zinc are aluminium, antimony, bismuth, gold, iron, lead, mercury, silver, tin, magnesium, cobalt, nickel, tellurium, and sodium. Although neither zinc nor zirconium are ferromagnetic, their alloy ZrZn exhibits ferromagnetism below 35 K. A bar of zinc generates a characteristic sound when bent, similar to tin cry. Occurrence See also : Zinc minerals Zinc makes up about 75 ppm ( 0.0075 % ) of Earth 's crust, making it the 24th most abundant element. Soil contains zinc in 5 -- 770 ppm with an average 64 ppm. Seawater has only 30 ppb and the atmosphere, 0.1 -- 4 μg / m. The element is normally found in association with other base metals such as copper and lead in ores. Zinc is a chalcophile, meaning the element is more likely to be found in minerals together with sulfur and other heavy chalcogens, rather than with the light chalcogen oxygen or with non-chalcogen electronegative elements such as the halogens. Sulfides formed as the crust solidified under the reducing conditions of the early Earth 's atmosphere. Sphalerite, which is a form of zinc sulfide, is the most heavily mined zinc - containing ore because its concentrate contains 60 -- 62 % zinc. Other source minerals for zinc include smithsonite ( zinc carbonate ), hemimorphite ( zinc silicate ), wurtzite ( another zinc sulfide ), and sometimes hydrozincite ( basic zinc carbonate ). With the exception of wurtzite, all these other minerals were formed by weathering of the primordial zinc sulfides. Identified world zinc resources total about 1.9 -- 2.8 billion tonnes. Large deposits are in Australia, Canada and the United States, with the largest reserves in Iran. The most recent estimate of reserve base for zinc ( meets specified minimum physical criteria related to current mining and production practices ) was made in 2009 and calculated to be roughly 480 Mt. Zinc reserves, on the other hand, are geologically identified ore bodies whose suitability for recovery is economically based ( location, grade, quality, and quantity ) at the time of determination. Since exploration and mine development is an ongoing process, the amount of zinc reserves is not a fixed number and sustainability of zinc ore supplies can not be judged by simply extrapolating the combined mine life of today 's zinc mines. This concept is well supported by data from the United States Geological Survey ( USGS ), which illustrates that although refined zinc production increased 80 % between 1990 and 2010, the reserve lifetime for zinc has remained unchanged. About 346 million tonnes have been extracted throughout history to 2002, and scholars have estimated that about 109 -- 305 million tonnes are in use. Sphalerite ( ZnS ) Isotopes Main article : Isotopes of zinc Five isotopes of zinc occur in nature. Zn is the most abundant isotope ( 48.63 % natural abundance ). That isotope has such a long half - life, at 7026135697680000000 ♠ 4.3 × 10 years, that its radioactivity can be ignored. Similarly, Zn ( 0.6 % ), with a half - life of 7023410248800000000 ♠ 1.3 × 10 years is not usually considered to be radioactive. The other isotopes found in nature are Zn ( 28 % ), Zn ( 4 % ) and Zn ( 19 % ). Several dozen radioisotopes have been characterized. Zn, which has a half - life of 243.66 days, is the least active radioisotope, followed by Zn with a half - life of 46.5 hours. Zinc has 10 nuclear isomers. Zn has the longest half - life, 13.76 h. The superscript m indicates a metastable isotope. The nucleus of a metastable isotope is in an excited state and will return to the ground state by emitting a photon in the form of a gamma ray. Zn has three excited metastable states and Zn has two. The isotopes Zn, Zn, Zn and Zn each have only one excited metastable state. The most common decay mode of a radioisotope of zinc with a mass number lower than 66 is electron capture. The decay product resulting from electron capture is an isotope of copper. Zn + → Cu The most common decay mode of a radioisotope of zinc with mass number higher than 66 is beta decay ( β ), which produces an isotope of gallium. Zn → Ga + + ν Compounds and Chemistry Main article : Compounds of zinc Reactivity See also : Clemmensen reduction Zinc has an electron configuration of ( Ar ) 3d 4s and is a member of the group 12 of the periodic table. It is a moderately reactive metal and strong reducing agent. The surface of the pure metal tarnishes quickly, eventually forming a protective passivating layer of the basic zinc carbonate, Zn ( OH ) ( CO ), by reaction with atmospheric carbon dioxide. This layer helps prevent further reaction with air and water. Zinc burns in air with a bright bluish - green flame, giving off fumes of zinc oxide. Zinc reacts readily with acids, alkalis and other non-metals. Extremely pure zinc reacts only slowly at room temperature with acids. Strong acids, such as hydrochloric or sulfuric acid, can remove the passivating layer and subsequent reaction with water releases hydrogen gas. The chemistry of zinc is dominated by the + 2 oxidation state. When compounds in this oxidation state are formed, the outer shell s electrons are lost, yielding a bare zinc ion with the electronic configuration ( Ar ) 3d. In aqueous solution an octahedral complex, ( Zn ( H O ) ) is the predominant species. The volatilization of zinc in combination with zinc chloride at temperatures above 285 ° C indicates the formation of Zn Cl, a zinc compound with a + 1 oxidation state. No compounds of zinc in oxidation states other than + 1 or + 2 are known. Calculations indicate that a zinc compound with the oxidation state of + 4 is unlikely to exist. Zinc chemistry is similar to the chemistry of the late first - row transition metals, nickel and copper, though it has a filled d - shell and compounds are diamagnetic and mostly colorless. The ionic radii of zinc and magnesium happen to be nearly identical. Because of this some of the equivalent salts have the same crystal structure, and in other circumstances where ionic radius is a determining factor, the chemistry of zinc has much in common with that of magnesium. In other respects, there is little similarity with the late first - row transition metals. Zinc tends to form bonds with a greater degree of covalency and much more stable complexes with N - and S - donors. Complexes of zinc are mostly 4 - or 6 - coordinate although 5 - coordinate complexes are known. Zinc ( I ) compounds Zinc ( I ) compounds are rare and need bulky ligands to stabilize the low oxidation state. Most zinc ( I ) compounds contain formally the ( Zn ) core, which is analogous to the ( Hg ) dimeric cation present in mercury ( I ) compounds. The diamagnetic nature of the ion confirms its dimeric structure. The first zinc ( I ) compound containing the Zn -- Zn bond, ( η - C Me ) Zn, is also the first dimetallocene. The ( Zn ) ion rapidly disproportionates into zinc metal and zinc ( II ), and has been obtained only a yellow glass only by cooling a solution of metallic zinc in molten ZnCl. Zinc ( II ) compounds Zinc acetate Zinc chloride Binary compounds of zinc are known for most of the metalloids and all the nonmetals except the noble gases. The oxide ZnO is a white powder that is nearly insoluble in neutral aqueous solutions, but is amphoteric, dissolving in both strong basic and acidic solutions. The other chalcogenides ( ZnS, ZnSe, and ZnTe ) have varied applications in electronics and optics. Pnictogenides ( Zn, Zn, Zn As and Zn Sb ), the peroxide ( ZnO ), the hydride ( ZnH ), and the carbide ( ZnC ) are also known. Of the four halides, ZnF has the most ionic character, while the others ( ZnCl, ZnBr, and ZnI ) have relatively low melting points and are considered to have more covalent character. In weak basic solutions containing Zn ions, the hydroxide Zn ( OH ) forms as a white precipitate. In stronger alkaline solutions, this hydroxide is dissolved to form zincates ( ( Zn ( OH ) ) ). The nitrate Zn ( NO ), chlorate Zn ( ClO ), sulfate ZnSO, phosphate Zn ( PO ), molybdate ZnMoO, cyanide Zn ( CN ), arsenite Zn ( AsO ), arsenate Zn ( AsO ) 8H O and the chromate ZnCrO ( one of the few colored zinc compounds ) are a few examples of other common inorganic compounds of zinc. One of the simplest examples of an organic compound of zinc is the acetate ( Zn ( O CCH ) ). Organozinc compounds are those that contain zinc -- carbon covalent bonds. Diethylzinc ( ( C H ) Zn ) is a reagent in synthetic chemistry. It was first reported in 1848 from the reaction of zinc and ethyl iodide, and was the first compound known to contain a metal -- carbon sigma bond. Test for zinc Cobalticyanide paper ( Rinnmann 's test for Zn ) can be used as a chemical indicator for zinc. 4 g of K Co ( CN ) and 1 g of KClO is dissolved on 100 ml of water. Paper is dipped in the solution and dried at 100 ° C. One drop of the sample is dropped onto the dry paper and heated. A green disc indicates the presence of zinc. History Ancient use Late Roman brass bucket -- the Hemmoorer Eimer from Warstade, Germany, second to third century AD Various isolated examples of the use of impure zinc in ancient times have been discovered. Zinc ores were used to make the zinc -- copper alloy brass thousands of years prior to the discovery of zinc as a separate element. Judean brass from the 14th to 10th centuries BC contains 23 % zinc. Knowledge of how to produce brass spread to Ancient Greece by the 7th century BC, but few varieties were made. Ornaments made of alloys containing 80 -- 90 % zinc, with lead, iron, antimony, and other metals making up the remainder, have been found that are 2,500 years old. A possibly prehistoric statuette containing 87.5 % zinc was found in a Dacian archaeological site. The oldest known pills were made of the zinc carbonates hydrozincite and smithsonite. The pills were used for sore eyes and were found aboard the Roman ship Relitto del Pozzino, wrecked in 140 BC. The manufacture of brass was known to the Romans by about 30 BC. They made brass by heating powdered calamine ( zinc silicate or carbonate ), charcoal and copper together in a crucible. The resulting calamine brass was then either cast or hammered into shape for use in weaponry. Some coins struck by Romans in the Christian era are made of what is probably calamine brass. Strabo writing in the 1st century BC ( but quoting a now lost work of the 4th century BC historian Theopompus ) mentions `` drops of false silver '' which when mixed with copper make brass. This may refer to small quantities of zinc that is a by - product of smelting sulfide ores. Zinc in such remnants in smelting ovens was usually discarded as it was thought to be worthless. The Berne zinc tablet is a votive plaque dating to Roman Gaul made of an alloy that is mostly zinc. The Charaka Samhita, thought to have been written between 300 and 500 AD, mentions a metal which, when oxidized, produces pushpanjan, thought to be zinc oxide. Zinc mines at Zawar, near Udaipur in India, have been active since the Mauryan period ( c. 322 and 187 BCE ). The smelting of metallic zinc here, however, appears to have begun around the 12th century AD. One estimate is that this location produced an estimated million tonnes of metallic zinc and zinc oxide from the 12th to 16th centuries. Another estimate gives a total production of 60,000 tonnes of metallic zinc over this period. The Rasaratna Samuccaya, written in approximately the 13th century AD, mentions two types of zinc - containing ores : one used for metal extraction and another used for medicinal purposes. Early studies and naming Zinc was distinctly recognized as a metal under the designation of Yasada or Jasada in the medical Lexicon ascribed to the Hindu king Madanapala ( of Taka dynasty ) and written about the year 1374. Smelting and extraction of impure zinc by reducing calamine with wool and other organic substances was accomplished in the 13th century in India. The Chinese did not learn of the technique until the 17th century. Various alchemical symbols for the element zinc Alchemists burned zinc metal in air and collected the resulting zinc oxide on a condenser. Some alchemists called this zinc oxide lana philosophica, Latin for `` philosopher 's wool '', because it collected in wooly tufts, whereas others thought it looked like white snow and named it nix album. The name of the metal was probably first documented by Paracelsus, a Swiss - born German alchemist, who referred to the metal as `` zincum '' or `` zinken '' in his book Liber Mineralium II, in the 16th century. The word is probably derived from the German zinke, and supposedly meant `` tooth - like, pointed or jagged '' ( metallic zinc crystals have a needle - like appearance ). Zink could also imply `` tin - like '' because of its relation to German zinn meaning tin. Yet another possibility is that the word is derived from the Persian word سنگ seng meaning stone. The metal was also called Indian tin, tutanego, calamine, and spinter. German metallurgist Andreas Libavius received a quantity of what he called `` calay '' of Malabar from a cargo ship captured from the Portuguese in 1596. Libavius described the properties of the sample, which may have been zinc. Zinc was regularly imported to Europe from the Orient in the 17th and early 18th centuries, but was at times very expensive. Andreas Sigismund Marggraf is given credit for first isolating pure zinc Isolation Metallic zinc was isolated in India by 1300 AD, much earlier than in the West. Before it was isolated in Europe, it was imported from India in about 1600 CE. Postlewayt 's Universal Dictionary, a contemporary source giving technological information in Europe, did not mention zinc before 1751 but the element was studied before then. Flemish metallurgist and alchemist P.M. de Respour reported that he had extracted metallic zinc from zinc oxide in 1668. By the start of the 18th century, Étienne François Geoffroy described how zinc oxide condenses as yellow crystals on bars of iron placed above zinc ore that is being smelted. In Britain, John Lane is said to have carried out experiments to smelt zinc, probably at Landore, prior to his bankruptcy in 1726. In 1738 in Great Britain, William Champion patented a process to extract zinc from calamine in a vertical retort style smelter. His technique resembled that used at Zawar zinc mines in Rajasthan, but no evidence suggests he visited the Orient. Champion 's process was used through 1851. German chemist Andreas Marggraf normally gets credit for discovering pure metallic zinc, even though Swedish chemist Anton von Swab had distilled zinc from calamine four years previously. In his 1746 experiment, Marggraf heated a mixture of calamine and charcoal in a closed vessel without copper to obtain a metal. This procedure became commercially practical by 1752. Later work Galvanization was named after Luigi Galvani. William Champion 's brother, John, patented a process in 1758 for calcining zinc sulfide into an oxide usable in the retort process. Prior to this, only calamine could be used to produce zinc. In 1798, Johann Christian Ruberg improved on the smelting process by building the first horizontal retort smelter. Jean - Jacques Daniel Dony built a different kind of horizontal zinc smelter in Belgium that processed even more zinc. Italian doctor Luigi Galvani discovered in 1780 that connecting the spinal cord of a freshly dissected frog to an iron rail attached by a brass hook caused the frog 's leg to twitch. He incorrectly thought he had discovered an ability of nerves and muscles to create electricity and called the effect `` animal electricity ''. The galvanic cell and the process of galvanization were both named for Luigi Galvani, and his discoveries paved the way for electrical batteries, galvanization, and cathodic protection. Galvani 's friend, Alessandro Volta, continued researching the effect and invented the Voltaic pile in 1800. The basic unit of Volta 's pile was a simplified galvanic cell, made of plates of copper and zinc separated by an electrolyte and connected by a conductor externally. The units were stacked in series to make the Voltaic cell, which produced electricity by directing electrons from the zinc to the copper and allowing the zinc to corrode. The non-magnetic character of zinc and its lack of color in solution delayed discovery of its importance to biochemistry and nutrition. This changed in 1940 when carbonic anhydrase, an enzyme that scrubs carbon dioxide from blood, was shown to have zinc in its active site. The digestive enzyme carboxypeptidase became the second known zinc - containing enzyme in 1955. Production Mining and Processing Top zinc output countries 2014 Rank Country Tonnes China 5,000,000 Australia 1,500,000 Peru 1,300,000 India 820,000 5 United States 700,000 6 Mexico 700,000 Main articles : Zinc mining and Zinc smelting See also : List of countries by zinc production Percentage of zinc output in 2006 by countries World production trend Zinc Mine Rosh Pinah, Namibia 27 ° 57 ′ 17 '' S 016 ° 46 ′ 00 '' E ﻿ / ﻿ 27.95472 ° S 16.76667 ° E ﻿ / - 27.95472 ; 16.76667 ﻿ ( Rosh Pinah ) Zinc Mine Skorpion, Namibia 27 ° 49 ′ 09 '' S 016 ° 36 ′ 28 '' E ﻿ / ﻿ 27.81917 ° S 16.60778 ° E ﻿ / - 27.81917 ; 16.60778 ﻿ ( Skorpion ) Zinc is the fourth most common metal in use, trailing only iron, aluminium, and copper with an annual production of about 13 million tonnes. The world 's largest zinc producer is Nyrstar, a merger of the Australian OZ Minerals and the Belgian Umicore. About 70 % of the world 's zinc originates from mining, while the remaining 30 % comes from recycling secondary zinc. Commercially pure zinc is known as Special High Grade, often abbreviated SHG, and is 99.995 % pure. Worldwide, 95 % of new zinc is mined from sulfidic ore deposits, in which sphalerite ( ZnS ) is nearly always mixed with the sulfides of copper, lead and iron. Zinc mines are scattered throughout the world, with the main areas being China, Australia, and Peru. China produced 38 % of the global zinc output in 2014. Zinc metal is produced using extractive metallurgy. The ore is finely ground, then put through froth flotation to separate minerals from gangue ( on the property of hydrophobicity ), to get a zinc sulfide ore concentrate consisting of about 50 % zinc, 32 % sulfur, 13 % iron, and 5 % SiO. Roasting converts the zinc sulfide concentrate to zinc oxide : 2 ZnS + 3 O → 2 ZnO + 2 SO The sulfur dioxide is used for the production of sulfuric acid, which is necessary for the leaching process. If deposits of zinc carbonate, zinc silicate, or zinc spinel ( like the Skorpion Deposit in Namibia ) are used for zinc production, the roasting can be omitted. For further processing two basic methods are used : pyrometallurgy or electrowinning. Pyrometallurgy reduces zinc oxide with carbon or carbon monoxide at 950 ° C ( 1,740 ° F ) into the metal, which is distilled as zinc vapor to separate it from other metals, which are not volatile at those temperatures. The zinc vapor is collected in a condenser. The equations below describe this process : 2 ZnO + C → 2 Zn + CO ZnO + CO → Zn + CO In electrowinning, zinc is leached from the ore concentrate by sulfuric acid : ZnO + H SO → ZnSO + H O Finally, the zinc is reduced by electrolysis. 2 ZnSO + 2 H O → 2 Zn + 2 H SO + O The sulfuric acid is regenerated and recycled to the leaching step. When galvanised feedstock is fed to an electric arc furnace, the zinc is recovered from the dust by a number of processes, predominately the Waelz process ( 90 % as of 2014 ). Environmental impact Refinement of sulfidic zinc ores produces large volumes of sulfur dioxide and cadmium vapor. Smelter slag and other residues contain significant quantities of metals. About 1.1 million tonnes of metallic zinc and 130 thousand tonnes of lead were mined and smelted in the Belgian towns of La Calamine and Plombières between 1806 and 1882. The dumps of the past mining operations leach zinc and cadmium, and the sediments of the Geul River contain non-trivial amounts of metals. About two thousand years ago, emissions of zinc from mining and smelting totaled 10 thousand tonnes a year. After increasing 10-fold from 1850, zinc emissions peaked at 3.4 million tonnes per year in the 1980s and declined to 2.7 million tonnes in the 1990s, although a 2005 study of the Arctic troposphere found that the concentrations there did not reflect the decline. Anthropogenic and natural emissions occur at a ratio of 20 to 1. Zinc in rivers flowing through industrial and mining areas can be as high as 20 ppm. Effective sewage treatment greatly reduces this ; treatment along the Rhine, for example, has decreased zinc levels to 50 ppb. Concentrations of zinc as low as 2 ppm adversely affects the amount of oxygen that fish can carry in their blood. Historically responsible for high metal levels in the Derwent River, the zinc works at Lutana is the largest exporter in Tasmania, generating 2.5 % of the state 's GDP, and producing more than 250 000 tonnes of zinc per year. Soils contaminated with zinc from mining, refining, or fertilizing with zinc - bearing sludge can contain several grams of zinc per kilogram of dry soil. Levels of zinc in excess of 500 ppm in soil interfere with the ability of plants to absorb other essential metals, such as iron and manganese. Zinc levels of 2000 ppm to 180,000 ppm ( 18 % ) have been recorded in some soil samples. Applications Major applications of zinc include ( numbers are given for the US ) Galvanizing ( 55 % ) Brass and bronze ( 16 % ) Other alloys ( 21 % ) Miscellaneous ( 8 % ) Anti-corrosion and batteries Hot - dip handrail galvanized crystalline surface Zinc is most commonly used as an anti-corrosion agent, and galvanization ( coating of iron or steel ) is the most familiar form. In 2009 in the United States, 55 % or 893 thousand tonnes of the zinc metal was used for galvanization. Zinc is more reactive than iron or steel and thus will attract almost all local oxidation until it completely corrodes away. A protective surface layer of oxide and carbonate ( Zn ( OH ) ( CO ) ) forms as the zinc corrodes. This protection lasts even after the zinc layer is scratched but degrades through time as the zinc corrodes away. The zinc is applied electrochemically or as molten zinc by hot - dip galvanizing or spraying. Galvanization is used on chain - link fencing, guard rails, suspension bridges, lightposts, metal roofs, heat exchangers, and car bodies. The relative reactivity of zinc and its ability to attract oxidation to itself makes it an efficient sacrificial anode in cathodic protection ( CP ). For example, cathodic protection of a buried pipeline can be achieved by connecting anodes made from zinc to the pipe. Zinc acts as the anode ( negative terminus ) by slowly corroding away as it passes electric current to the steel pipeline. Zinc is also used to cathodically protect metals that are exposed to sea water. A zinc disc attached to a ship 's iron rudder will slowly corrode while the rudder stays intact. Similarly, a zinc plug attached to a propeller or the metal protective guard for the keel of the ship provides temporary protection. With a standard electrode potential ( SEP ) of − 0.76 volts, zinc is used as an anode material for batteries. ( More reactive lithium ( SEP − 3.04 V ) is used for anodes in lithium batteries ). Powdered zinc is used in this way in alkaline batteries and the case ( which also serves as the anode ) of zinc -- carbon batteries is formed from sheet zinc. Zinc is used as the anode or fuel of the zinc - air battery / fuel cell. The zinc - cerium redox flow battery also relies on a zinc - based negative half - cell. Alloys A widely used zinc alloy is brass, in which copper is alloyed with anywhere from 3 % to 45 % zinc, depending upon the type of brass. Brass is generally more ductile and stronger than copper, and has superior corrosion resistance. These properties make it useful in communication equipment, hardware, musical instruments, and water valves. Cast brass microstructure at magnification 400x Other widely used zinc alloys include nickel silver, typewriter metal, soft and aluminium solder, and commercial bronze. Zinc is also used in contemporary pipe organs as a substitute for the traditional lead / tin alloy in pipes. Alloys of 85 -- 88 % zinc, 4 -- 10 % copper, and 2 -- 8 % aluminium find limited use in certain types of machine bearings. Zinc is the primary metal in American one cent coins ( pennies ) since 1982. The zinc core is coated with a thin layer of copper to give the appearance of a copper coin. In 1994, 33,200 tonnes ( 36,600 short tons ) of zinc were used to produce 13.6 billion pennies in the United States. Alloys of zinc with small amounts of copper, aluminium, and magnesium are useful in die casting as well as spin casting, especially in the automotive, electrical, and hardware industries. These alloys are marketed under the name Zamak. An example of this is zinc aluminium. The low melting point together with the low viscosity of the alloy makes possible the production of small and intricate shapes. The low working temperature leads to rapid cooling of the cast products and fast production for assembly. Another alloy, marketed under the brand name Prestal, contains 78 % zinc and 22 % aluminium, and is reported to be nearly as strong as steel but as malleable as plastic. This superplasticity of the alloy allows it to be molded using die casts made of ceramics and cement. Similar alloys with the addition of a small amount of lead can be cold - rolled into sheets. An alloy of 96 % zinc and 4 % aluminium is used to make stamping dies for low production run applications for which ferrous metal dies would be too expensive. For building facades, roofing, and other applications for sheet metal formed by deep drawing, roll forming, or bending, zinc alloys with titanium and copper are used. Unalloyed zinc is too brittle for these manufacturing processes. As a dense, inexpensive, easily worked material, zinc is used as a lead replacement. In the wake of lead concerns, zinc appears in weights for various applications ranging from fishing to tire balances and flywheels. Cadmium zinc telluride ( CZT ) is a semiconductive alloy that can be divided into an array of small sensing devices. These devices are similar to an integrated circuit and can detect the energy of incoming gamma ray photons. When behind an absorbing mask, the CZT sensor array can determine the direction of the rays. Other industrial uses Zinc oxide is used as a white pigment in paints. Roughly one quarter of all zinc output in the United States in 2009 was consumed in zinc compounds ; a variety of which are used industrially. Zinc oxide is widely used as a white pigment in paints and as a catalyst in the manufacture of rubber to disburse heat. Zinc oxide is used to protect rubber polymers and plastics from ultraviolet radiation ( UV ). The semiconductor properties of zinc oxide make it useful in varistors and photocopying products. The zinc zinc - oxide cycle is a two step thermochemical process based on zinc and zinc oxide for hydrogen production. Zinc chloride is often added to lumber as a fire retardant and sometimes as a wood preservative. It is used in the manufacture of other chemicals. Zinc methyl ( Zn ( CH ) ) is used in a number of organic syntheses. Zinc sulfide ( ZnS ) is used in luminescent pigments such as on the hands of clocks, X-ray and television screens, and luminous paints. Crystals of ZnS are used in lasers that operate in the mid-infrared part of the spectrum. Zinc sulfate is a chemical in dyes and pigments. Zinc pyrithione is used in antifouling paints. Zinc powder is sometimes used as a propellant in model rockets. When a compressed mixture of 70 % zinc and 30 % sulfur powder is ignited there is a violent chemical reaction. This produces zinc sulfide, together with large amounts of hot gas, heat, and light. Zinc sheet metal is used to make zinc bars. Zn, the most abundant isotope of zinc, is very susceptible to neutron activation, being transmuted into the highly radioactive Zn, which has a half - life of 244 days and produces intense gamma radiation. Because of this, zinc oxide used in nuclear reactors as an anti-corrosion agent is depleted of Zn before use, this is called depleted zinc oxide. For the same reason, zinc has been proposed as a salting material for nuclear weapons ( cobalt is another, better - known salting material ). A jacket of isotopically enriched Zn would be irradiated by the intense high - energy neutron flux from an exploding thermonuclear weapon, forming a large amount of Zn significantly increasing the radioactivity of the weapon 's fallout. Such a weapon is not known to have ever been built, tested, or used. Zn is used as a tracer to study how alloys that contain zinc wear out, or the path and the role of zinc in organisms. Zinc dithiocarbamate complexes are used as agricultural fungicides ; these include Zineb, Metiram, Propineb and Ziram. Zinc naphthenate is used as wood preservative. Zinc in the form of ZDDP, is used as an anti-wear additive for metal parts in engine oil. Organic Chemistry Addition of diphenylzinc to an aldehyde Organozinc chemistry is the science of compounds that contain carbon - zinc bonds, describing the physical properties, synthesis, and chemical reactions. Many organozinc compounds are important. Among important applications are The Frankland - Duppa Reaction in which an oxalate ester ( ROCOCOOR ) reacts with an alkyl halide R'X, zinc and hydrochloric acid to form the α - hydroxycarboxylic esters RR'COHCOOR The Reformatskii reaction in which α - halo - esters and aldehydes are converted to β - hydroxy - esters The Simmons -- Smith reaction in which the carbenoid ( iodomethyl ) zinc iodide reacts with alkene ( or alkyne ) and converts them to cyclopropane The Addition reaction of organozinc compounds to form carbonyl compounds The Barbier reaction ( 1899 ), which is the zinc equivalent of the magnesium Grignard reaction and is the better of the two. In presence of water, formation of the organomagnesium halide will fail, whereas the Barbier reaction can take place in water. On the downside, organozincs are much less nucleophilic than Grignards, and they are expensive and difficult to handle. Commercially available diorganozinc compounds are dimethylzinc, diethylzinc and diphenylzinc. In one study, the active organozinc compound is obtained from much cheaper organobromine precursors The Negishi coupling is also an important reaction for the formation of new carbon - carbon bonds between unsaturated carbon atoms in alkenes, arenes and alkynes. The catalysts are nickel and palladium. A key step in the catalytic cycle is a transmetalation in which a zinc halide exchanges its organic substituent for another halogen with the palladium ( nickel ) metal center. The Fukuyama coupling is another coupling reaction, but it uses a thioester as reactant and produces a ketone. Zinc has found many applications as catalyst in organic synthesis including asymmetric synthesis, being cheap and easily available alternative to precious metal complexes. The results ( yield and ee ) obtained with chiral zinc catalysts are comparable to those achieved with palladium, ruthenium, iridium and others, and zinc becomes metal catalyst of choice. Dietary supplement GNC zinc 50 mg tablets. The amount exceeds what is deemed the safe upper limit in the United States ( 40 mg ) and European Union ( 25 mg ) Zinc gluconate is one compound used for the delivery of zinc as a dietary supplement. See also : Zinc sulfate ( medical use ) In most single - tablet, over-the - counter, daily vitamin and mineral supplements, zinc is included in such forms as zinc oxide, zinc acetate, or zinc gluconate. Zinc is generally considered to be an antioxidant. However, it is redox inert and thus can serve such a function only indirectly. Zinc deficiency has been associated with major depressive disorder ( MDD ), and zinc supplements may be an effective treatment. Zinc serves as a simple, inexpensive, and critical tool for treating diarrheal episodes among children in the developing world. Zinc becomes depleted in the body during diarrhea, but recent studies suggest that replenishing zinc with a 10 - to 14 - day course of treatment can reduce the duration and severity of diarrheal episodes and may also prevent future episodes for as long as three months. A Cochrane review stated that people taking zinc supplement may be less likely to progress to age - related macular degeneration. Zinc supplement is an effective treatment for acrodermatitis enteropathica, a genetic disorder affecting zinc absorption that was previously fatal to affected infants. Gastroenteritis is strongly attenuated by ingestion of zinc, possibly by direct antimicrobial action of the ions in the gastrointestinal tract, or by the absorption of the zinc and re-release from immune cells ( all granulocytes secrete zinc ), or both. In 2011, researchers reported that adding large amounts of zinc to a urine sample masked detection of drugs. The researchers did not test whether orally consuming a zinc dietary supplement could have the same effect. Common cold This section is transcluded from Zinc and the common cold. ( edit history ) Zinc supplements ( frequently zinc acetate or zinc gluconate lozenges ) are a group of dietary supplements that are commonly used for the treatment of the common cold. The use of zinc supplements at doses in excess of 75 mg / day within 24 hours of the onset of symptoms has been shown to reduce the duration of cold symptoms by about 1 day. Due to a lack of data, there is insufficient evidence to determine whether the preventative use of zinc supplements reduces the likelihood of contracting a cold. Adverse effects with zinc supplements by mouth include bad taste and nausea. The intranasal use of zinc - containing nasal sprays has been associated with the loss of the sense of smell ; consequently, in June 2009, the United States Food and Drug Administration ( USFDA ) warned consumers to stop using intranasal zinc products. The human rhinovirus -- the most common viral pathogen in humans -- is the predominant cause of the common cold. The hypothesized mechanism of action by which zinc reduces the severity and / or duration of cold symptoms is the suppression of nasal inflammation and the direct inhibition of rhinoviral receptor binding and rhinoviral replication in the nasal mucosa. Topical use Further information : Zinc oxide § Medicine Topical preparations of zinc include those used on the skin, often in the form of zinc oxide. Zinc preparations can protect against sunburn in the summer and windburn in the winter. Applied thinly to a baby 's diaper area ( perineum ) with each diaper change, it can protect against diaper rash. Chelated zinc is used in toothpastes and mouthwashes to prevent bad breath. Zinc pyrithione is widely included in shampoos to prevent dandruff. Biological role Zinc is an essential trace element for humans and other animals, for plants and for microorganisms. Zinc is required for the function of over 300 enzymes and 1000 transcription factors, and is stored and transferred in metallothioneins. It is the second most abundant trace metal in humans after iron and it is the only metal which appears in all enzyme classes. In proteins, zinc ions are often coordinated to the amino acid side chains of aspartic acid, glutamic acid, cysteine and histidine. The theoretical and computational description of this zinc binding in proteins ( as well as that of other transition metals ) is difficult. Roughly 2 -- 4 grams of zinc are distributed throughout the human body. Most zinc is in the brain, muscle, bones, kidney, and liver, with the highest concentrations in the prostate and parts of the eye. Semen is particularly rich in zinc, a key factor in prostate gland function and reproductive organ growth. In humans, the biological roles of zinc are ubiquitous. It interacts with `` a wide range of organic ligands '', and has roles in the metabolism of RNA and DNA, signal transduction, and gene expression. It also regulates apoptosis. A 2006 study estimated that about 10 % of human proteins ( 2800 ) potentially bind zinc, in addition to hundreds more that transport and traffic zinc ; a similar in silico study in the plant Arabidopsis thaliana found 2367 zinc - related proteins. In the brain, zinc is stored in specific synaptic vesicles by glutamatergic neurons and can modulate neuronal excitability. It plays a key role in synaptic plasticity and so in learning. Zinc homeostasis also plays a critical role in the functional regulation of the central nervous system. Dysregulation of zinc homeostasis in the central nervous system that results in excessive synaptic zinc concentrations is believed to induce neurotoxicity through mitochondrial oxidative stress ( e.g., by disrupting certain enzymes involved in the electron transport chain, including complex I, complex III, and α - ketoglutarate dehydrogenase ), the dysregulation of calcium homeostasis, glutamatergic neuronal excitotoxicity, and interference with intraneuronal signal transduction. L - and D - histidine facilitate brain zinc uptake. SLC30A3 is the primary zinc transporter involved in cerebral zinc homeostasis. Enzymes Ribbon diagram of human carbonic anhydrase II, with zinc atom visible in the center Zinc fingers help read DNA sequences. Zinc is an efficient Lewis acid, making it a useful catalytic agent in hydroxylation and other enzymatic reactions. The metal also has a flexible coordination geometry, which allows proteins using it to rapidly shift conformations to perform biological reactions. Two examples of zinc - containing enzymes are carbonic anhydrase and carboxypeptidase, which are vital to the processes of carbon dioxide ( CO ) regulation and digestion of proteins, respectively. In vertebrate blood, carbonic anhydrase converts CO into bicarbonate and the same enzyme transforms the bicarbonate back into CO for exhalation through the lungs. Without this enzyme, this conversion would occur about one million times slower at the normal blood pH of 7 or would require a pH of 10 or more. The non-related β - carbonic anhydrase is required in plants for leaf formation, the synthesis of indole acetic acid ( auxin ) and alcoholic fermentation. Carboxypeptidase cleaves peptide linkages during digestion of proteins. A coordinate covalent bond is formed between the terminal peptide and a C =O group attached to zinc, which gives the carbon a positive charge. This helps to create a hydrophobic pocket on the enzyme near the zinc, which attracts the non-polar part of the protein being digested. Signalling Zinc has been recognized as a messenger, able to activate signalling pathways. Many of these pathways provide the driving force in aberrant cancer growth. They can be targeted through ZIP transporters. Other proteins Zinc serves a purely structural role in zinc fingers, twists and clusters. Zinc fingers form parts of some transcription factors, which are proteins that recognize DNA base sequences during the replication and transcription of DNA. Each of the nine or ten Zn ions in a zinc finger helps maintain the finger 's structure by coordinately binding to four amino acids in the transcription factor. The transcription factor wraps around the DNA helix and uses its fingers to accurately bind to the DNA sequence. In blood plasma, zinc is bound to and transported by albumin ( 60 %, low - affinity ) and transferrin ( 10 % ). Because transferrin also transports iron, excessive iron reduces zinc absorption, and vice versa. A similar antagonism exists with copper. The concentration of zinc in blood plasma stays relatively constant regardless of zinc intake. Cells in the salivary gland, prostate, immune system, and intestine use zinc signaling to communicate with other cells. Zinc may be held in metallothionein reserves within microorganisms or in the intestines or liver of animals. Metallothionein in intestinal cells is capable of adjusting absorption of zinc by 15 -- 40 %. However, inadequate or excessive zinc intake can be harmful ; excess zinc particularly impairs copper absorption because metallothionein absorbs both metals. The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine - induced dopamine efflux in vitro. The human serotonin transporter and norepinephrine transporter do not contain zinc binding sites. Dietary recommendations The U.S. Institute of Medicine ( IOM ) updated Estimated Average Requirements ( EARs ) and Recommended Dietary Allowances ( RDAs ) for zinc in 2001. The current EARs for zinc for women and men ages 14 and up is 6.8 and 9.4 mg / day, respectively. The RDAs are 8 and 11 mg / day. RDAs are higher than EARs so as to identify amounts that will cover people with higher than average requirements. RDA for pregnancy is 11 mg / day. RDA for lactation is 12 mg / day. For infants up to 12 months the RDA is 3 mg / day. For children ages 1 -- 13 years the RDA increases with age from 3 to 8 mg / day. As for safety, the IOM sets Tolerable upper intake levels ( ULs ) for vitamins and minerals when evidence is sufficient. In the case of zinc the adult UL is 40 mg / day ( lower for children ). Collectively the EARs, RDAs, AIs and ULs are referred to as Dietary Reference Intakes ( DRIs ). The European Food Safety Authority ( EFSA ) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake ( PRI ) instead of RDA, and Average Requirement instead of EAR. AI and UL are defined the same as in United States. For people ages 18 and older the PRI calculations are complex, as the EFSA has set higher and higher values as the phytate content of the diet increases. For women, PRIs increase from 7.5 to 12.7 mg / day as phytate intake increases from 300 to 1200 mg / day ; for men the range is 9.4 to 16.3 mg / day. These PRIs are higher than the U.S. RDAs. The EFSA reviewed the same safety question and set its UL at 25 mg / day, which is much lower than the U.S. value. For U.S. food and dietary supplement labeling purposes the amount in a serving is expressed as a percent of Daily Value ( % DV ). For zinc labeling purposes 100 % of the Daily Value was 15 mg, but as of May 27, 2016 it has been revised to 11 mg. A table of the old and new adult Daily Values is provided at Reference Daily Intake. Food and supplement companies have until January 1, 2020 to comply with the change. Dietary intake Foods and spices containing zinc Animal products such as meat, fish, shellfish, fowl, eggs, and dairy contain zinc. The concentration of zinc in plants varies with the level in the soil. With adequate zinc in the soil, the food plants that contain the most zinc are wheat ( germ and bran ) and various seeds, including sesame, poppy, alfalfa, celery, and mustard. Zinc is also found in beans, nuts, almonds, whole grains, pumpkin seeds, sunflower seeds, and blackcurrant. Plant phytates interfere with zinc absorption, so people consuming a vegetarian or vegan diet may need to increase zinc intake. Other sources include fortified food and dietary supplements in various forms. A 1998 review concluded that zinc oxide, one of the most common supplements in the United States, and zinc carbonate are nearly insoluble and poorly absorbed in the body. This review cited studies that found lower plasma zinc concentrations in the subjects who consumed zinc oxide and zinc carbonate than in those who took zinc acetate and sulfate salts. For fortification, however, a 2003 review recommended cereals ( containing zinc oxide ) as a cheap, stable source that is as easily absorbed as the more expensive forms. A 2005 study found that various compounds of zinc, including oxide and sulfate, did not show statistically significant differences in absorption when added as fortificants to maize tortillas. Deficiency Main article : Zinc deficiency Zinc deficiency is usually due to insufficient dietary intake, but can be associated with malabsorption, acrodermatitis enteropathica, chronic liver disease, chronic renal disease, sickle cell disease, diabetes, malignancy, and other chronic illnesses. Groups at risk of zinc deficiency include the elderly, children in developing countries, and those with renal dysfunction. In the United States, a federal survey of food consumption determined that for women and men over the age of 19, average consumption was 9.7 and 14.2 mg / day, respectively. For women, 17 % consumed less than the EAR, for men 11 %. The percentages below EAR increased with age. The most recent published update of the survey ( NHANES 2013 -- 2014 ) reported lower averages -- 9.3 and 13.2 mg / day -- again with intake decreasing with age. Symptoms of mild zinc deficiency are diverse. Clinical outcomes include depressed growth, diarrhea, impotence and delayed sexual maturation, alopecia, eye and skin lesions, impaired appetite, altered cognition, impaired host defense properties, defects in carbohydrate utilization, and reproductive teratogenesis. Mild zinc deficiency depresses immunity, although excessive zinc does also. Animals with a zinc deficiency require twice as much food to attain the same weight gain as animals with sufficient zinc. Despite some concerns, western vegetarians and vegans do not suffer any more from overt zinc deficiency than meat - eaters. Major plant sources of zinc include cooked dried beans, sea vegetables, fortified cereals, soy foods, nuts, peas, and seeds. However, phytates in many whole - grains and fibers may interfere with zinc absorption and marginal zinc intake has poorly understood effects. The zinc chelator phytate, found in seeds and cereal bran, can contribute to zinc malabsorption. Some evidence suggests that more than the US RDA ( 15 mg ) of zinc daily may be needed in those whose diet is high in phytates, such as some vegetarians. These considerations must be balanced against the paucity of adequate zinc biomarkers, and the most widely used indicator, plasma zinc, has poor sensitivity and specificity. Diagnosing zinc deficiency is a persistent challenge. Nearly two billion people in the developing world are deficient in zinc. In children, it causes an increase in infection and diarrhea and contributes to the death of about 800,000 children worldwide per year. The World Health Organization advocates zinc supplementation for severe malnutrition and diarrhea. Zinc supplements help prevent disease and reduce mortality, especially among children with low birth weight or stunted growth. However, zinc supplements should not be administered alone, because many in the developing world have several deficiencies, and zinc interacts with other micronutrients. Soil remediation Species of Calluna, Erica and Vaccinium can grow in zinc metalliferous soils, because translocation of toxic ions is prevented by the action of ericoid mycorrhizal fungi. Agriculture Zinc deficiency appears to be the most common micronutrient deficiency in crop plants ; it is particularly common in high - pH soils. Zinc - deficient soil is cultivated in the cropland of about half of Turkey and India, a third of China, and most of Western Australia. Substantial responses to zinc fertilization have been reported in these areas. Plants that grow in soils that are zinc - deficient are more susceptible to disease. Zinc is added to the soil primarily through the weathering of rocks, but humans have added zinc through fossil fuel combustion, mine waste, phosphate fertilizers, pesticide ( zinc phosphide ), limestone, manure, sewage sludge, and particles from galvanized surfaces. Excess zinc is toxic to plants, although zinc toxicity is far less widespread. Precautions Main article : Zinc toxicity Toxicity Although zinc is an essential requirement for good health, excess zinc can be harmful. Excessive absorption of zinc suppresses copper and iron absorption. The free zinc ion in solution is highly toxic to plants, invertebrates, and even vertebrate fish. The Free Ion Activity Model is well - established in the literature, and shows that just micromolar amounts of the free ion kills some organisms. A recent example showed 6 micromolar killing 93 % of all Daphnia in water. The free zinc ion is a powerful Lewis acid up to the point of being corrosive. Stomach acid contains hydrochloric acid, in which metallic zinc dissolves readily to give corrosive zinc chloride. Swallowing a post-1982 American one cent piece ( 97.5 % zinc ) can cause damage to the stomach lining through the high solubility of the zinc ion in the acidic stomach. Evidence shows that people taking 100 -- 300 mg of zinc daily may suffer induced copper deficiency. A 2007 trial observed that elderly men taking 80 mg daily were hospitalized for urinary complications more often than those taking a placebo. Levels of 100 -- 300 mg may interfere with the utilization of copper and iron or adversely affect cholesterol. Zinc in excess of 500 ppm in soil interferes with the plant absorption of other essential metals, such as iron and manganese. A condition called the zinc shakes or `` zinc chills '' can be induced by inhalation of zinc fumes while brazing or welding galvanized materials. Zinc is a common ingredient of denture cream which may contain between 17 and 38 mg of zinc per gram. Disability and even deaths from excessive use of these products have been claimed. The U.S. Food and Drug Administration ( FDA ) states that zinc damages nerve receptors in the nose, causing anosmia. Reports of anosmia were also observed in the 1930s when zinc preparations were used in a failed attempt to prevent polio infections. On June 16, 2009, the FDA ordered removal of zinc - based intranasal cold products from store shelves. The FDA said the loss of smell can be life - threatening because people with impaired smell can not detect leaking gas or smoke, and can not tell if food has spoiled before they eat it. Recent research suggests that the topical antimicrobial zinc pyrithione is a potent heat shock response inducer that may impair genomic integrity with induction of PARP - dependent energy crisis in cultured human keratinocytes and melanocytes. Poisoning In 1982, the US Mint began minting pennies coated in copper but containing primarily zinc. Zinc pennies pose a risk of zinc toxicosis, which can be fatal. One reported case of chronic ingestion of 425 pennies ( over 1 kg of zinc ) resulted in death due to gastrointestinal bacterial and fungal sepsis. Another patient who ingested 12 grams of zinc showed only lethargy and ataxia ( gross lack of coordination of muscle movements ). Several other cases have been reported of humans suffering zinc intoxication by the ingestion of zinc coins. Pennies and other small coins are sometimes ingested by dogs, requiring veterinary removal of the foreign objects. The zinc content of some coins can cause zinc toxicity, commonly fatal in dogs through severe hemolytic anemia and liver or kidney damage ; vomiting and diarrhea are possible symptoms. Zinc is highly toxic in parrots and poisoning can often be fatal. The consumption of fruit juices stored in galvanized cans has resulted in mass parrot poisonings with zinc. See also List of countries by zinc production Spelter Wet storage stain Zinc alloy electroplating Notes Jump up ^ An East India Company ship carrying a cargo of nearly pure zinc metal from the Orient sank off the coast Sweden in 1745. ( Emsley 2001, p. 502 ) Jump up ^ Electric current will naturally flow between zinc and steel but in some circumstances inert anodes are used with an external DC source. References Jump up ^ Meija, J. ; et al. ( 2016 ). `` Atomic weights of the elements 2013 ( IUPAC Technical Report ) ''. Pure and Applied Chemistry. 88 ( 3 ) : 265 -- 91. doi : 10.1515 / pac - 2015 - 0305. Jump up ^ Weast, Robert ( 1984 ). CRC, Handbook of Chemistry and Physics. Boca Raton, Florida : Chemical Rubber Company Publishing. pp. E110. ISBN 0 - 8493 - 0464 - 4. Jump up ^ Thornton, C.P. ( 2007 ). `` Of brass and bronze in prehistoric Southwest Asia '' ( PDF ). Papers and Lectures Online. Archetype Publications. ISBN 1 - 904982 - 19 - 0. Archived ( PDF ) from the original on September 24, 2015. ^ Jump up to : Greenwood 1997, p. 1201 ^ Jump up to : Craddock, Paul T. ( 1978 ). `` The composition of copper alloys used by the Greek, Etruscan and Roman civilizations. The origins and early use of brass ''. Journal of Archaeological Science. 5 ( 1 ) : 1 -- 16. doi : 10.1016 / 0305 - 4403 ( 78 ) 90015 - 8. Jump up ^ `` Royal Society Of Chemistry ''. Archived from the original on July 11, 2017. Jump up ^ `` India Was the First to Smelt Zinc by Distillation Process ''. Infinityfoundation.com. Archived from the original on May 16, 2016. Retrieved April 25, 2014. Jump up ^ Kharakwal, J.S. & Gurjar, L.K. ( December 1, 2006 ). `` Zinc and Brass in Archaeological Perspective ''. Ancient Asia. 1 : 139 -- 159. doi : 10.5334 / aa. 06112. Archived from the original on December 3, 2013. ^ Jump up to : Hambidge, K.M. & Krebs, N.F. ( 2007 ). `` Zinc deficiency : a special challenge ''. J. Nutr. 137 ( 4 ) : 1101 -- 5. PMID 17374687. ^ Jump up to : Prasad, A.S. ( 2003 ). `` Zinc deficiency : Has been known of for 40 years but ignored by global health organisations ''. British Medical Journal. 326 ( 7386 ) : 409 -- 10. doi : 10.1136 / bmj. 326.7386. 409. PMC 1125304. PMID 12595353. Jump up ^ Maret, Wolfgang ( 2013 ). `` Chapter 14 Zinc and the Zinc Proteome ''. In Banci, Lucia. Metallomics and the Cell. Metal Ions in Life Sciences. 12. Springer. doi : 10.1007 / 978 - 94 - 007 - 5561 - 10_14. ISBN 978 - 94 - 007 - 5561 - 1. ^ Jump up to : CRC 2006, p. 4 -- 41 ^ Jump up to : Heiserman 1992, p. 123 Jump up ^ Wells A.F. ( 1984 ) Structural Inorganic Chemistry 5th edition p 1277 Oxford Science Publications ISBN 0 - 19 - 855370 - 6 Jump up ^ Scoffern, John ( 1861 ). The Useful Metals and Their Alloys. Houlston and Wright. pp. 591 -- 603. Retrieved April 6, 2009. ^ Jump up to : `` Zinc Metal Properties ''. American Galvanizers Association. 2008. Archived from the original on April 7, 2015. Retrieved April 7, 2015. Jump up ^ Ingalls, Walter Renton ( 1902 ). Production and Properties of Zinc : A Treatise on the Occurrence and Distribution of Zinc Ore, the Commercial and Technical Conditions Affecting the Production of the Spelter, Its Chemical and Physical Properties and Uses in the Arts, Together with a Historical and Statistical Review of the Industry. The Engineering and Mining Journal. pp. 142 -- 6. ^ Jump up to : Emsley 2001, p. 503 ^ Jump up to : Lehto 1968, p. 822 ^ Jump up to : Greenwood 1997, p. 1202 ^ Jump up to : Emsley 2001, p. 502 ^ Jump up to : Tolcin, A.C. ( 2015 ). `` Mineral Commodity Summaries 2015 : Zinc '' ( PDF ). United States Geological Survey. Archived ( PDF ) from the original on May 25, 2015. Retrieved May 27, 2015. Jump up ^ Erickson, R.L. ( 1973 ). `` Crustal Abundance of Elements, and Mineral Reserves and Resources ''. U.S. Geological Survey Professional Paper 820 : 21 -- 25. Jump up ^ `` Country Partnership Strategy -- Iran : 2011 -- 12 ''. ECO Trade and development bank. Archived from the original on October 26, 2011. Retrieved June 6, 2011. CS1 maint : BOT : original - url status unknown ( link ) Jump up ^ `` IRAN -- a growing market with enormous potential ''. IMRG. July 5, 2010. Archived from the original on February 17, 2013. Retrieved March 3, 2010. Jump up ^ Tolcin, A.C. ( 2009 ). `` Mineral Commodity Summaries 2009 : Zinc '' ( PDF ). United States Geological Survey. Archived ( PDF ) from the original on July 2, 2016. Retrieved August 4, 2016. Jump up ^ Gordon, R.B. ; Bertram, M. ; Graedel, T.E. ( 2006 ). `` Metal stocks and sustainability ''. Proceedings of the National Academy of Sciences. 103 ( 5 ) : 1209 -- 14. Bibcode : 2006PNAS... 103.1209 G. doi : 10.1073 / pnas. 0509498103. PMC 1360560. PMID 16432205. Jump up ^ Gerst, Michael ( 2008 ). `` In - Use Stocks of Metals : Status and Implications ''. Environmental Science and Technology. 42 ( 19 ) : 7038 -- 45. Bibcode : 2008EnST... 42.7038 G. doi : 10.1021 / es800420p. PMID 18939524. Jump up ^ Meylan, Gregoire ( 2016 ). `` The anthropogenic cycle of zinc : Status quo and perspectives ''. Resources, Conservation and Recycling. 123 : In press. doi : 10.1016 / j. resconrec. 2016.01. 006. ^ Jump up to : NNDC contributors ( 2008 ). Alejandro A. Sonzogni ( Database Manager ), ed. `` Chart of Nuclides ''. Upton ( NY ) : National Nuclear Data Center, Brookhaven National Laboratory. Archived from the original on May 22, 2008. Retrieved September 13, 2008. Jump up ^ CRC 2006, p. 11 -- 70 Jump up ^ NASA contributors. `` Five - Year Wilkinson Microwave Anisotropy Probe ( WMAP ) Observations : Data Processing, Sky Maps, and Basic Results '' ( PDF ). NASA. Archived ( PDF ) from the original on April 9, 2008. Retrieved March 6, 2008. Jump up ^ Audi, Georges ; Bersillon, O. ; Blachot, J. ; Wapstra, A.H. ( 2003 ). `` The NUBASE Evaluation of Nuclear and Decay Properties ''. Nuclear Physics A. Atomic Mass Data Center. 729 ( 1 ) : 3 -- 128. Bibcode : 2003NuPhA. 729... 3A. doi : 10.1016 / j. nuclphysa. 2003.11. 001. Archived from the original on January 3, 2017. Jump up ^ CRC 2006, pp. 8 -- 29 Jump up ^ Porter, Frank C. ( 1994 ). Corrosion Resistance of Zinc and Zinc Alloys. CRC Press. p. 121. ISBN 0 - 8247 - 9213 - 0. ^ Jump up to : Holleman, Arnold F. ; Wiberg, Egon ; Wiberg, Nils ( 1985 ). `` Zink ''. Lehrbuch der Anorganischen Chemie ( in German ) ( 91 -- 100 ed. ). Walter de Gruyter. pp. 1034 -- 1041. ISBN 3 - 11 - 007511 - 3. Jump up ^ Hinds, John Iredelle Dillard ( 1908 ). Inorganic Chemistry : With the Elements of Physical and Theoretical Chemistry ( 2nd ed. ). New York : John Wiley & Sons. pp. 506 -- 508. Jump up ^ Ritchie, Rob ( 2004 ). Chemistry ( 2nd ed. ). Letts and Lonsdale. p. 71. ISBN 1 - 84315 - 438 - 2. Jump up ^ Burgess, John ( 1978 ). Metal ions in solution. New York : Ellis Horwood. p. 147. ISBN 0 - 470 - 26293 - 1. Jump up ^ Brady, James E. ; Humiston, Gerard E. ; Heikkinen, Henry ( 1983 ). General Chemistry : Principles and Structure ( 3rd ed. ). John Wiley & Sons. p. 671. ISBN 0 - 471 - 86739 - X. Jump up ^ Kaupp M. ; Dolg M. ; Stoll H. ; Von Schnering H.G. ( 1994 ). `` Oxidation state + IV in group 12 chemistry. Ab initio study of zinc ( IV ), cadmium ( IV ), and mercury ( IV ) fluorides ''. Inorganic Chemistry. 33 ( 10 ) : 2122 -- 2131. doi : 10.1021 / ic00088a012. ^ Jump up to : Greenwood 1997, p. 1206 Jump up ^ CRC 2006, pp. 12 -- 11 -- 12 Jump up ^ Housecroft, C.E. ; Sharpe, A.G. ( 2008 ). Inorganic Chemistry ( 3rd ed. ). Prentice Hall. p. 739 -- 741, 843. ISBN 978 - 0131755536. Jump up ^ `` Zinc Sulfide ''. American Elements. Archived from the original on July 17, 2012. Retrieved February 3, 2009. Jump up ^ Grolier contributors ( 1994 ). Academic American Encyclopedia. Danbury, Connecticut : Grolier Inc. p. 202. ISBN 0 - 7172 - 2053 - 2. Jump up ^ `` Zinc Phosphide ''. American Elements. Archived from the original on July 17, 2012. Retrieved February 3, 2009. Jump up ^ Shulzhenko, A.A. ; Ignatyeva, I. Yu. ; Osipov, A.S. ; Smirnova, T.I. ( 2000 ). `` Peculiarities of interaction in the Zn -- C system under high pressures and temperatures ''. Diamond and Related Materials. 9 ( 2 ) : 129 -- 133. Bibcode : 2000DRM... 9... 129S. doi : 10.1016 / S0925 - 9635 ( 99 ) 00231 - 9. Jump up ^ Greenwood 1997, p. 1211 Jump up ^ Rasmussen, J.K. ; Heilmann, S.M. ( 1990 ). `` In situ Cyanosilylation of Carbonyl Compounds : O - Trimethylsilyl - 4 - Methoxymandelonitrile ''. Organic Syntheses, Collected Volume. 7 : 521. Archived from the original on September 30, 2007. Jump up ^ Perry, D.L. ( 1995 ). Handbook of Inorganic Compounds. CRC Press. pp. 448 -- 458. ISBN 0 - 8493 - 8671 - 3. Jump up ^ Frankland, E. ( 1850 ). `` On the isolation of the organic radicals ''. Quarterly Journal of the Chemical Society. 2 ( 3 ) : 263. doi : 10.1039 / QJ8500200263. Jump up ^ Lide, David ( 1998 ). CRC - Handbook of Chemistry and Physics. CRC press. pp. Section 8 Page 1. ISBN 0 - 8493 - 0479 - 2. Jump up ^ Weeks 1933, p. 20 Jump up ^ `` World 's oldest pills treated sore eyes ''. New Scientist. January 7, 2013. Archived from the original on January 22, 2013. Retrieved February 5, 2013. Jump up ^ `` Ingredients of a 2,000 - y - old medicine revealed by chemical, mineralogical, and botanical investigations ''. Bibcode : 2013PNAS... 110.1193 G. doi : 10.1073 / pnas. 1216776110. ^ Jump up to : Emsley 2001, p. 501 Jump up ^ `` How is zinc made ? ''. How Products are Made. The Gale Group. 2002. Archived from the original on April 11, 2006. Retrieved February 21, 2009. CS1 maint : BOT : original - url status unknown ( link ) Jump up ^ Chambers 1901, p. 799 Jump up ^ Craddock, P.T. ( 1998 ). `` Zinc in classical antiquity ''. In Craddock, P.T. 2000 years of zinc and brass ( rev. ed. ). London : British Museum. pp. 3 -- 5. ISBN 0 - 86159 - 124 - 0. ^ Jump up to : Weeks 1933, p. 21 Jump up ^ Rehren, Th. ( 1996 ). S. Demirci ; et al., eds. A Roman zinc tablet from Bern, Switzerland : Reconstruction of the Manufacture. Archaeometry 94. The Proceedings of the 29th International Symposium on Archaeometry. pp. 35 -- 45. Jump up ^ Meulenbeld, G.J. ( 1999 ). A History of Indian Medical Literature. IA. Groningen : Forsten. pp. 130 -- 141. OCLC 165833440. Jump up ^ Craddock, P.T. ; et al. ( 1998 ). `` Zinc in India ''. 2000 years of zinc and brass ( rev. ed. ). London : British Museum. p. 27. ISBN 0 - 86159 - 124 - 0. ^ Jump up to : p. 46, Ancient mining and metallurgy in Rajasthan, S.M. Gandhi, chapter 2 in Crustal Evolution and Metallogeny in the Northwestern Indian Shield : A Festschrift for Asoke Mookherjee, M. Deb, ed., Alpha Science Int'l Ltd., 2000, ISBN 1 - 84265 - 001 - 7. ^ Jump up to : Craddock, P.T. ; Gurjar L.K. ; Hegde K.T.M. ( 1983 ). `` Zinc production in medieval India ''. World Archaeology. Taylor & Francis. 15 ( 2 ) : 211 -- 217. doi : 10.1080 / 00438243.1983. 9979899. JSTOR 124653. Jump up ^ Ray, Prafulla Chandra ( 1903 ). A History of Hindu Chemistry from the Earliest Times to the Middle of the Sixteenth Century, A.D. : With Sanskrit Texts, Variants, Translation and Illustrations. 1 ( 2nd ed. ). The Bengal Chemical & Pharmaceutical Works, Ltd. pp. 157 -- 158. ( public domain text ) ^ Jump up to : Habashi, Fathi. `` Discovering the 8th Metal '' ( PDF ). International Zinc Association ( IZA ). Archived from the original ( PDF ) on March 4, 2009. Retrieved December 13, 2008. Jump up ^ Arny, Henry Vinecome ( 1917 ). Principles of Pharmacy ( 2nd ed. ). W.B. Saunders company. p. 483. Jump up ^ Hoover, Herbert Clark ( 2003 ). Georgius Agricola de Re Metallica. Kessinger Publishing. p. 409. ISBN 0 - 7661 - 3197 - 1. Jump up ^ Gerhartz, Wolfgang ; et al. ( 1996 ). Ullmann 's Encyclopedia of Industrial Chemistry ( 5th ed. ). VHC. p. 509. ISBN 3 - 527 - 20100 - 9. Jump up ^ Skeat, W. W ( 2005 ). Concise Etymological Dictionary of the English Language. Cosimo, Inc. p. 622. ISBN 1 - 59605 - 092 - 6. Jump up ^ Fathi Habashi ( 1997 ). Handbook of Extractive Metallurgy. Wiley - VHC. p. 642. ISBN 3 - 527 - 28792 - 2. Jump up ^ Lach, Donald F. ( 1994 ). `` Technology and the Natural Sciences ''. Asia in the Making of Europe. University of Chicago Press. p. 426. ISBN 0 - 226 - 46734 - 1. Jump up ^ Vaughan, L Brent ( 1897 ). `` Zincography ''. The Junior Encyclopedia Britannica A Reference Library of General Knowledge Volume III P-Z. Chicago : E.G. Melven & Company. Jump up ^ Castellani, Michael. `` Transition Metal Elements '' ( PDF ). Archived ( PDF ) from the original on October 10, 2014. Retrieved October 14, 2014. Jump up ^ Habib, Irfan ( 2011 ). Chatopadhyaya, D.P., ed. Economic History of Medieval India, 1200 -- 1500. New Delhi : Pearson Longman. p. 86. ISBN 978 - 81 - 317 - 2791 - 1. Archived from the original on April 14, 2016. ^ Jump up to : Jenkins, Rhys ( 1945 ). `` The Zinc Industry in England : the early years up to 1850 ''. Transactions of the Newcomen Society. 25 : 41 -- 52. doi : 10.1179 / tns. 1945.006. Jump up ^ Willies, Lynn ; Craddock, P.T. ; Gurjar, L.J. ; Hegde, K.T.M. ( 1984 ). `` Ancient Lead and Zinc Mining in Rajasthan, India ''. World Archaeology. 16 ( 2, Mines and Quarries ) : 222 -- 233. doi : 10.1080 / 00438243.1984. 9979929. JSTOR 124574. Jump up ^ Roberts, R.O. ( 1951 ). `` Dr John Lane and the foundation of the non-ferrous metal industry in the Swansea valley ''. Gower. Gower Society ( 4 ) : 19. Jump up ^ Comyns, Alan E. ( 2007 ). Encyclopedic Dictionary of Named Processes in Chemical Technology ( 3rd ed. ). CRC Press. p. 71. ISBN 0 - 8493 - 9163 - 6. Jump up ^ Heiserman 1992, p. 122 Jump up ^ Gray, Leon ( 2005 ). Zinc. Marshall Cavendish. p. 8. ISBN 0 - 7614 - 1922 - 5. ^ Jump up to : Warren, Neville G. ( 2000 ). Excel Preliminary Physics. Pascal Press. p. 47. ISBN 1 - 74020 - 085 - 3. ^ Jump up to : `` Galvanic Cell ''. The New International Encyclopaedia. Dodd, Mead and Company. 1903. p. 80. ^ Jump up to : Cotton 1999, p. 626 Jump up ^ Jasinski, Stephen M. `` Mineral Commodity Summaries 2007 : Zinc '' ( PDF ). United States Geological Survey. Archived ( PDF ) from the original on December 17, 2008. Retrieved November 25, 2008. Jump up ^ Attwood, James ( February 13, 2006 ). `` Zinifex, Umicore Combine to Form Top Zinc Maker ''. Wall Street Journal. Archived from the original on January 26, 2017. Jump up ^ `` Zinc Recycling ''. International Zinc Association. Archived from the original on October 21, 2011. Retrieved November 28, 2008. CS1 maint : BOT : original - url status unknown ( link ) Jump up ^ `` Special High Grade Zinc ( SHG ) 99.995 % '' ( PDF ). Nyrstar. 2008. Archived from the original ( PDF ) on March 4, 2009. Retrieved December 1, 2008. ^ Jump up to : Porter, Frank C. ( 1991 ). Zinc Handbook. CRC Press. ISBN 978 - 0 - 8247 - 8340 - 2. ^ Jump up to : Rosenqvist, Terkel ( 1922 ). Principles of Extractive Metallurgy ( 2nd ed. ). Tapir Academic Press. pp. 7, 16, 186. ISBN 82 - 519 - 1922 - 3. Jump up ^ Borg, Gregor ; Kärner, Katrin ; Buxton, Mike ; Armstrong, Richard ; van der Merwe, Schalk W. ( 2003 ). `` Geology of the Skorpion Supergene Zinc Deposit, Southern Namibia ''. Economic Geology. 98 ( 4 ) : 749. doi : 10.2113 / 98.4. 749. Jump up ^ Bodsworth, Colin ( 1994 ). The Extraction and Refining of Metals. CRC Press. p. 148. ISBN 0 - 8493 - 4433 - 6. Jump up ^ Gupta, C.K. ; Mukherjee, T.K. ( 1990 ). Hydrometallurgy in Extraction Processes. CRC Press. p. 62. ISBN 0 - 8493 - 6804 - 9. Jump up ^ Antrekowitsch, Jürgen ; Steinlechner, Stefan ; Unger, Alois ; Rösler, Gernot ; Pichler, Christoph ; Rumpold, Rene ( 2014 ), `` 9. Zinc and Residue Recycling '', in Worrell, Ernst ; Reuter, Markus, Handbook of Recycling : State - of - the - art for Practitioners, Analysts, and Scientists ^ Jump up to : Kucha, H. ; Martens, A. ; Ottenburgs, R. ; De Vos, W. ; Viaene, W. ( 1996 ). `` Primary minerals of Zn - Pb mining and metallurgical dumps and their environmental behavior at Plombières, Belgium ''. Environmental Geology. 27 ( 1 ) : 1 -- 15. Bibcode : 1996EnGeo... 27... 1K. doi : 10.1007 / BF00770598. ^ Jump up to : Broadley, M.R. ; White, P.J. ; Hammond, J.P. ; Zelko I. ; Lux A. ( 2007 ). `` Zinc in plants ''. New Phytologist. 173 ( 4 ) : 677 -- 702. doi : 10.1111 / j. 1469 - 8137.2007. 01996. x. PMID 17286818. ^ Jump up to : Emsley 2001, p. 504 Jump up ^ Heath, Alan G. ( 1995 ). Water pollution and fish physiology. Boca Raton, Florida : CRC Press. p. 57. ISBN 0 - 87371 - 632 - 9. Jump up ^ `` Derwent Estuary -- Water Quality Improvement Plan for Heavy Metals ''. Derwent Estuary Program. June 2007. Archived from the original on March 21, 2012. Retrieved July 11, 2009. CS1 maint : BOT : original - url status unknown ( link ) Jump up ^ `` The Zinc Works ''. TChange. Archived from the original on April 27, 2009. Retrieved July 11, 2009. ^ Jump up to : `` Zinc : World Mine Production ( zinc content of concentrate ) by Country '' ( PDF ). 2009 Minerals Yearbook : Zinc. Washington, D.C. : United States Geological Survey. February 2010. Archived ( PDF ) from the original on June 8, 2011. Retrieved June 6, 2001. Jump up ^ Greenwood 1997, p. 1203 ^ Jump up to : Stwertka 1998, p. 99 ^ Jump up to : Lehto 1968, p. 829 Jump up ^ Bounoughaz, M. ; Salhi, E. ; Benzine, K. ; Ghali E. ; Dalard F. ( 2003 ). `` A comparative study of the electrochemical behaviour of Algerian zinc and a zinc from a commercial sacrificial anode ''. Journal of Materials Science. 38 ( 6 ) : 1139 -- 1145. Bibcode : 2003JMatS... 38.1139 B. doi : 10.1023 / A : 1022824813564. Jump up ^ Besenhard, Jürgen O. ( 1999 ). Handbook of Battery Materials. Wiley - VCH. ISBN 3 - 527 - 29469 - 4. Jump up ^ Wiaux, J. - P. ; Waefler, J. - P. ( 1995 ). `` Recycling zinc batteries : an economical challenge in consumer waste management ''. Journal of Power Sources. 57 ( 1 -- 2 ) : 61 -- 65. Bibcode : 1995JPS... 57... 61W. doi : 10.1016 / 0378 - 7753 ( 95 ) 02242 - 2. Jump up ^ Culter, T. ( 1996 ). `` A design guide for rechargeable zinc - air battery technology ''. Southcon / 96. Conference Record : 616. doi : 10.1109 / SOUTHC. 1996.535134. ISBN 0 - 7803 - 3268 - 7. Jump up ^ Whartman, Jonathan ; Brown, Ian. `` Zinc Air Battery - Battery Hybrid for Powering Electric Scooters and Electric Buses '' ( PDF ). The 15th International Electric Vehicle Symposium. Archived from the original on March 12, 2006. Retrieved October 8, 2008. CS1 maint : BOT : original - url status unknown ( link ) Jump up ^ Cooper, J.F. ; Fleming, D. ; Hargrove, D. ; Koopman, R. ; Peterman, K. `` A refuelable zinc / air battery for fleet electric vehicle propulsion ''. Society of Automotive Engineers future transportation technology conference and exposition. Archived from the original on January 12, 2012. Retrieved October 8, 2008. Jump up ^ Xie, Z. ; Liu, Q. ; Chang, Z. ; Zhang, X. ( 2013 ). `` The developments and challenges of cerium half - cell in zinc -- cerium redox flow battery for energy storage ''. Electrochimica Acta. 90 : 695 -- 704. doi : 10.1016 / j. electacta. 2012.12. 066. Jump up ^ Bush, Douglas Earl ; Kassel, Richard ( 2006 ). The Organ : An Encyclopedia. Routledge. p. 679. ISBN 978 - 0 - 415 - 94174 - 7. Jump up ^ `` Coin Specifications ''. United States Mint. Archived from the original on February 18, 2015. Retrieved October 8, 2008. Jump up ^ Jasinski, Stephen M. `` Mineral Yearbook 1994 : Zinc '' ( PDF ). United States Geological Survey. Archived ( PDF ) from the original on October 29, 2008. Retrieved November 13, 2008. Jump up ^ Eastern Alloys contributors. `` Diecasting Alloys ''. Maybrook, NY : Eastern Alloys. Archived from the original on December 25, 2008. Retrieved January 19, 2009. Jump up ^ Apelian, D. ; Paliwal, M. ; Herrschaft, D.C. ( 1981 ). `` Casting with Zinc Alloys ''. Journal of Metals. 33 ( 11 ) : 12 -- 19. Bibcode : 1981JOM... 33k... 12A. doi : 10.1007 / bf03339527. Jump up ^ Davies, Geoff ( 2003 ). Materials for automobile bodies. Butterworth - Heinemann. p. 157. ISBN 0 - 7506 - 5692 - 1. Jump up ^ Samans, Carl Hubert ( 1949 ). Engineering Metals and Their Alloys. Macmillan Co. ^ Jump up to : Porter, Frank ( 1994 ). `` Wrought Zinc ''. Corrosion Resistance of Zinc and Zinc Alloys. CRC Press. pp. 6 -- 7. ISBN 978 - 0 - 8247 - 9213 - 8. Jump up ^ McClane, Albert Jules & Gardner, Keith ( 1987 ). The Complete book of fishing : a guide to freshwater, saltwater & big - game fishing. Gallery Books. ISBN 978 - 0 - 8317 - 1565 - 6. Archived from the original on November 15, 2012. Retrieved June 26, 2012. Jump up ^ `` Cast flywheel on old Magturbo trainer has been recalled since July 2000 ''. Minoura. Archived from the original on March 23, 2013. CS1 maint : BOT : original - url status unknown ( link ) ^ Jump up to : Katz, Johnathan I. ( 2002 ). The Biggest Bangs. Oxford University Press. p. 18. ISBN 0 - 19 - 514570 - 4. Jump up ^ Zhang, Xiaoge Gregory ( 1996 ). Corrosion and Electrochemistry of Zinc. Springer. p. 93. ISBN 0 - 306 - 45334 - 7. Jump up ^ Weimer, Al ( May 17, 2006 ). `` Development of Solar - powered Thermochemical Production of Hydrogen from Water '' ( PDF ). U.S. Department of Energy. Archived ( PDF ) from the original on February 5, 2009. Retrieved January 10, 2009. ^ Jump up to : Heiserman 1992, p. 124 Jump up ^ Blew, Joseph Oscar ( 1953 ). `` Wood preservatives '' ( PDF ). Department of Agriculture, Forest Service, Forest Products Laboratory. hdl : 1957 / 816. Archived ( PDF ) from the original on January 14, 2012. Jump up ^ Frankland, Edward ( 1849 ). `` Notiz über eine neue Reihe organischer Körper, welche Metalle, Phosphor u.s.w. enthalten ''. Liebig 's Annalen der Chemie und Pharmacie ( in German ). 71 ( 2 ) : 213 -- 216. doi : 10.1002 / jlac. 18490710206. ^ Jump up to : CRC 2006, p. 4 - 42 Jump up ^ Paschotta, Rüdiger ( 2008 ). Encyclopedia of Laser Physics and Technology. Wiley - VCH. p. 798. ISBN 3 - 527 - 40828 - 2. Jump up ^ Konstantinou, I.K. ; Albanis, T.A. ( 2004 ). `` Worldwide occurrence and effects of antifouling paint booster biocides in the aquatic environment : a review ''. Environment International. 30 ( 2 ) : 235 -- 248. doi : 10.1016 / S0160 - 4120 ( 03 ) 00176 - 4. ^ Jump up to : Boudreaux, Kevin A. `` Zinc + Sulfur ''. Angelo State University. Archived from the original on December 2, 2008. Retrieved October 8, 2008. Jump up ^ `` Technical Information ''. Zinc Counters. 2008. Archived from the original on November 21, 2008. Retrieved November 29, 2008. ^ Jump up to : Win, David Tin ; Masum, Al ( 2003 ). `` Weapons of Mass Destruction '' ( PDF ). Assumption University Journal of Technology. Assumption University. 6 ( 4 ) : 199. Archived ( PDF ) from the original on March 26, 2009. Retrieved April 6, 2009. Jump up ^ David E. Newton ( 1999 ). Chemical Elements : From Carbon to Krypton. U.X.L. / Gale. ISBN 0 - 7876 - 2846 - 8. Archived from the original on July 10, 2008. Retrieved April 6, 2009. Jump up ^ Ullmann 's Agrochemicals. Wiley - Vch ( COR ). 2007. pp. 591 -- 592. ISBN 3 - 527 - 31604 - 3. Jump up ^ Walker, J.C.F. ( 2006 ). Primary Wood Processing : Principles and Practice. Springer. p. 317. ISBN 1 - 4020 - 4392 - 9. Jump up ^ `` ZDDP Engine Oil -- The Zinc Factor ''. Mustang Monthly. Archived from the original on September 12, 2009. Retrieved September 19, 2009. Jump up ^ Overman, Larry E. ; Carpenter, Nancy E. ( 2005 ). `` The Allylic Trihaloacetimidate Rearrangement ''. Organic Reactions. 66 : 1 -- 107. doi : 10.1002 / 0471264180. or066. 01. ISBN 0 - 471 - 26418 - 0. Jump up ^ Rappoport, Zvi ; Marek, Ilan ( December 17, 2007 ). The Chemistry of Organozinc Compounds : R - Zn. ISBN 0 - 470 - 09337 - 4. Archived from the original on April 14, 2016. Jump up ^ Knochel, Paul ; Jones, Philip ( 1999 ). Organozinc reagents : A practical approach. ISBN 0 - 19 - 850121 - 8. Archived from the original on April 14, 2016. Jump up ^ Herrmann, Wolfgang A. ( January 2002 ). Synthetic Methods of Organometallic and Inorganic Chemistry : Catalysis. ISBN 3 - 13 - 103061 - 5. Archived from the original on April 14, 2016. Jump up ^ E. Frankland, Ann. 126, 109 ( 1863 ) ; E. Frankland, B.F. Duppa, Ann. 135, 25 ( 1865 ) Jump up ^ Kim, Jeung Gon ; Walsh, Patrick J. ( 2006 ). `` From Aryl Bromides to Enantioenriched Benzylic Alcohols in a Single Flask : Catalytic Asymmetric Arylation of Aldehydes ''. Angewandte Chemie International Edition. 45 ( 25 ) : 4175 -- 4178. doi : 10.1002 / anie. 200600741. PMID 16721894. Jump up ^ In this one - pot reaction bromobenzene is converted to phenyllithium by reaction with 4 equivalents of n - butyllithium, then transmetalation with zinc chloride forms diphenylzinc that continues to react in an asymmetric reaction first with the MIB ligand and then with 2 - naphthylaldehyde to the alcohol. In this reaction formation of diphenylzinc is accompanied by that of lithium chloride, which if unchecked, catalyses the reaction without MIB involvement to the racemic alcohol. The salt is effectively removed by chelation with tetraethylethylene diamine ( TEEDA ) resulting in an enantiomeric excess of 92 %. Jump up ^ Łowicki, Daniel ; Baś, Sebastian ; Mlynarski, Jacek ( 2015 ). `` Chiral zinc catalysts for asymmetric synthesis ''. Tetrahedron. 71 ( 9 ) : 1339 -- 1394. doi : 10.1016 / j. tet. 2014.12. 022. Jump up ^ DiSilvestro, Robert A. ( 2004 ). Handbook of Minerals as Nutritional Supplements. CRC Press. pp. 135, 155. ISBN 0 - 8493 - 1652 - 9. Jump up ^ Zinc Biochemistry : From a Single Zinc Enzyme to a Key Element of Life. Wolfgang Maret 2013 Jump up ^ Swardfager W, Herrmann N, McIntyre RS, Mazereeuw G, Goldberger K, Cha DS, Schwartz Y, Lanctôt KL ( June 2013 ). `` Potential roles of zinc in the pathophysiology and treatment of major depressive disorder ''. Neurosci. Biobehav. Rev. 37 ( 5 ) : 911 -- 929. doi : 10.1016 / j. neubiorev. 2013.03. 018. PMID 23567517. Jump up ^ Bhutta, Z.A. ; Bird, S.M. ; Black, R.E. ; Brown, K.H. ; Gardner, J.M. ; Hidayat, A. ; Khatun, F. ; Martorell, R. ; et al. ( 2000 ). `` Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries : pooled analysis of randomized controlled trials ''. The American Journal of Clinical Nutrition. 72 ( 6 ) : 1516 -- 22. PMID 11101480. Jump up ^ Evans JR, Lawrenson JG ( 2017 ). `` Antioxidant vitamin and mineral supplements for slowing the progression of age - related macular degeneration ''. Cochrane Database Syst Rev. 7 : CD000254. doi : 10.1002 / 14651858. CD000254. pub4. PMID 28756618. Jump up ^ Aydemir, T.B. ; Blanchard, R.K. ; Cousins, R.J. ( 2006 ). `` Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations ''. PNAS. 103 ( 6 ) : 1699 -- 704. Bibcode : 2006PNAS... 103.1699 A. doi : 10.1073 / pnas. 0510407103. PMC 1413653. PMID 16434472. Jump up ^ Valko, M. ; Morris, H. ; Cronin, M.T.D. ( 2005 ). `` Metals, Toxicity and Oxidative stress '' ( PDF ). Current Medicinal Chemistry. 12 ( 10 ) : 1161 -- 208. doi : 10.2174 / 0929867053764635. PMID 15892631. Archived from the original ( PDF ) on August 8, 2017. Jump up ^ Venkatratnam, Abhishek ; Nathan Lents ( July 1, 2011 ). `` Zinc Reduces the Detection of Cocaine, Methamphetamine, and THC by ELISA Urine Testing ''. Journal of Analytical Toxicology. 35 ( 6 ) : 333 -- 340. doi : 10.1093 / anatox / 35.6. 333. PMID 21740689. ^ Jump up to : `` Zinc -- Fact Sheet for Health Professionals ''. Office of Dietary Supplements, US National Institutes of Health. February 11, 2016. Retrieved January 7, 2018. ^ Jump up to : Singh M, Das RR ( June 2013 ). `` Zinc for the common cold ''. The Cochrane Database of Systematic Reviews ( 6 ) : CD001364. doi : 10.1002 / 14651858. CD001364. pub4. PMID 23775705. Jump up ^ `` Common Cold and Runny Nose ''. United States Centers for Disease Control and Prevention. September 26, 2017. Retrieved January 7, 2018. Jump up ^ Roldán, S. ; Winkel, E.G. ; Herrera, D. ; Sanz, M. ; Van Winkelhoff, A.J. ( 2003 ). `` The effects of a new mouthrinse containing chlorhexidine, cetylpyridinium chloride and zinc lactate on the microflora of oral halitosis patients : a dual - centre, double - blind placebo - controlled study ''. Journal of Clinical Periodontology. 30 ( 5 ) : 427 -- 434. doi : 10.1034 / j. 1600 - 051X. 2003.20004. x. Jump up ^ Marks, R. ; Pearse, A.D. ; Walker, A.P. ( 1985 ). `` The effects of a shampoo containing zinc pyrithione on the control of dandruff ''. British Journal of Dermatology. 112 ( 4 ) : 415 -- 422. doi : 10.1111 / j. 1365 - 2133.1985. tb02314. x. Jump up ^ Maret, Wolfgang ( 2013 ). `` Chapter 12. Zinc and Human Disease ''. In Astrid Sigel ; Helmut Sigel ; Roland K.O. Sigel. Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 389 -- 414. doi : 10.1007 / 978 - 94 - 007 - 7500 - 8_12. ^ Jump up to : Prakash A, Bharti K, Majeed AB ( April 2015 ). `` Zinc : indications in brain disorders ''. Fundam Clin Pharmacol. 29 ( 2 ) : 131 -- 149. doi : 10.1111 / fcp. 12110. PMID 25659970. ^ Jump up to : Cherasse Y, Urade Y ( November 2017 ). `` Dietary Zinc Acts as a Sleep Modulator ''. International Journal of Molecular Sciences. 18 ( 11 ) : 2334. doi : 10.3390 / ijms18112334. PMC 5713303. PMID 29113075. Zinc is the second most abundant trace metal in the human body, and is essential for many biological processes... The trace metal zinc is an essential cofactor for more than 300 enzymes and 1000 transcription factors ( 16 )... In the central nervous system, zinc is the second most abundant trace metal and is involved in many processes. In addition to its role in enzymatic activity, it also plays a major role in cell signaling and modulation of neuronal activity. Jump up ^ Prasad A.S. ( 2008 ). `` Zinc in Human Health : Effect of Zinc on Immune Cells ''. Mol. Med. 14 ( 5 -- 6 ) : 353 -- 7. doi : 10.2119 / 2008 - 00033. Prasad. PMC 2277319. PMID 18385818. Jump up ^ Zinc 's role in microorganisms is particularly reviewed in : Sugarman B ( 1983 ). `` Zinc and infection ''. Review of Infectious Diseases. 5 ( 1 ) : 137 -- 47. doi : 10.1093 / clinids / 5.1. 137. PMID 6338570. Jump up ^ Cotton 1999, pp. 625 -- 629 Jump up ^ Plum, Laura ; Rink, Lothar ; Haase, Hajo ( 2010 ). `` The Essential Toxin : Impact of Zinc on Human Health ''. Int J Environ Res Public Health. 7 ( 4 ) : 1342 -- 1365. doi : 10.3390 / ijerph7041342. PMC 2872358. PMID 20617034. Jump up ^ Brandt, Erik G. ; Hellgren, Mikko ; Brinck, Tore ; Bergman, Tomas ; Edholm, Olle ( 2009 ). `` Molecular dynamics study of zinc binding to cysteines in a peptide mimic of the alcohol dehydrogenase structural zinc site '' ( PDF ). Phys. Chem. Chem. Phys. 11 ( 6 ) : 975 -- 83. Bibcode : 2009PCCP... 11... 975B. doi : 10.1039 / b815482a. PMID 19177216. ^ Jump up to : Rink, L. ; Gabriel P. ( 2000 ). `` Zinc and the immune system ''. Proc Nutr Soc. 59 ( 4 ) : 541 -- 52. doi : 10.1017 / S0029665100000781. PMID 11115789. Jump up ^ Wapnir, Raul A. ( 1990 ). Protein Nutrition and Mineral Absorption. Boca Raton, Florida : CRC Press. ISBN 0 - 8493 - 5227 - 4. Jump up ^ Berdanier, Carolyn D. ; Dwyer, Johanna T. ; Feldman, Elaine B. ( 2007 ). Handbook of Nutrition and Food. Boca Raton, Florida : CRC Press. ISBN 0 - 8493 - 9218 - 7. ^ Jump up to : Bitanihirwe BK, Cunningham MG ( November 2009 ). `` Zinc : the brain 's dark horse ''. Synapse. 63 ( 11 ) : 1029 -- 1049. doi : 10.1002 / syn. 20683. PMID 19623531. Jump up ^ Nakashima AS ; Dyck RH ( 2009 ). `` Zinc and cortical plasticity ''. Brain Res Rev. 59 ( 2 ) : 347 -- 73. doi : 10.1016 / j. brainresrev. 2008.10. 003. PMID 19026685. Jump up ^ Tyszka - Czochara M, Grzywacz A, Gdula - Argasińska J, Librowski T, Wiliński B, Opoka W ( May 2014 ). `` The role of zinc in the pathogenesis and treatment of central nervous system ( CNS ) diseases. Implications of zinc homeostasis for proper CNS function '' ( PDF ). Acta. Pol. Pharm. 71 ( 3 ) : 369 -- 377. PMID 25265815. Archived ( PDF ) from the original on August 29, 2017. Jump up ^ PMID 17119290 Jump up ^ NRC 2000, p. 443 Jump up ^ Stipanuk, Martha H. ( 2006 ). Biochemical, Physiological & Molecular Aspects of Human Nutrition. W.B. Saunders Company. pp. 1043 -- 1067. ISBN 978 - 0 - 7216 - 4452 - 3. ^ Jump up to : Greenwood 1997, pp. 1224 -- 1225 Jump up ^ Kohen, Amnon ; Limbach, Hans - Heinrich ( 2006 ). Isotope Effects in Chemistry and Biology. Boca Raton, Florida : CRC Press. p. 850. ISBN 0 - 8247 - 2449 - 6. ^ Jump up to : Greenwood 1997, p. 1225 Jump up ^ Cotton 1999, p. 627 Jump up ^ Gadallah, M.A.A. ( 2000 ). `` Effects of indole - 3 - acetic acid and zinc on the growth, osmotic potential and soluble carbon and nitrogen components of soybean plants growing under water deficit ''. Journal of Arid Environments. 44 ( 4 ) : 451 -- 467. doi : 10.1006 / jare. 1999.0610. Jump up ^ Ziliotto, Silvia ; Ogle, Olivia ; Yaylor, Kathryn M. ( 2018 ). `` Chapter 17. Targeting Zinc ( II ) Signalling to Prevent Cancer ''. In Sigel, Astrid ; Sigel, Helmut ; Freisinger, Eva ; Sigel, Roland K.O. Metallo - Drugs : Development and Action of Anticancer Agents. 18. Berlin : de Gruyter GmbH. pp. 507 -- 529. doi : 10.1515 / 9783110470734 - 023. Jump up ^ Cotton 1999, p. 628 Jump up ^ Whitney, Eleanor Noss ; Rolfes, Sharon Rady ( 2005 ). Understanding Nutrition ( 10th ed. ). Thomson Learning. pp. 447 -- 450. ISBN 978 - 1 - 4288 - 1893 - 4. ^ Jump up to : NRC 2000, p. 447 Jump up ^ Hershfinkel, Michal ; Silverman, William F. ; Sekler, Israel ( 2007 ). `` The Zinc Sensing Receptor, a Link Between Zinc and Cell Signaling ''. Molecular Medicine. 13 ( 7 -- 8 ) : 331 -- 6. doi : 10.2119 / 2006 - 00038. Hershfinkel. PMC 1952663. PMID 17728842. Jump up ^ Cotton 1999, p. 629 Jump up ^ Blake, Steve ( 2007 ). Vitamins and Minerals Demystified. McGraw - Hill Professional. p. 242. ISBN 0 - 07 - 148901 - 0. ^ Jump up to : Fosmire, G.J. ( 1990 ). `` Zinc toxicity ''. American Journal of Clinical Nutrition. 51 ( 2 ) : 225 -- 7. doi : 10.1093 / ajcn / 51.2. 225. PMID 2407097. Jump up ^ Krause J ( April 2008 ). `` SPECT and PET of the dopamine transporter in attention - deficit / hyperactivity disorder ''. Expert Rev. Neurother. 8 ( 4 ) : 611 -- 625. doi : 10.1586 / 14737175.8. 4.611. PMID 18416663. Jump up ^ Sulzer D ( February 2011 ). `` How addictive drugs disrupt presynaptic dopamine neurotransmission ''. Neuron. 69 ( 4 ) : 628 -- 649. doi : 10.1016 / j. neuron. 2011.02. 010. PMC 3065181. PMID 21338876. ^ Jump up to : Scholze P, Nørregaard L, Singer EA, Freissmuth M, Gether U, Sitte HH ( June 2002 ). `` The role of zinc ions in reverse transport mediated by monoamine transporters ''. J. Biol. Chem. 277 ( 24 ) : 21505 -- 21513. doi : 10.1074 / jbc. M112265200. PMID 11940571. The human dopamine transporter ( hDAT ) contains an endogenous high affinity Zn binding site with three coordinating residues on its extracellular face ( His193, His375, and Glu396 )... Thus, when Zn is co-released with glutamate, it may greatly augment the efflux of dopamine. Jump up ^ `` Zinc '' Archived September 19, 2017, at the Wayback Machine., pp. 442 -- 501 in Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press. 2001. Jump up ^ `` Overview on Dietary Reference Values for the EU population as derived by the EFSA Panel on Dietetic Products, Nutrition and Allergies '' ( PDF ). 2017. Archived ( PDF ) from the original on August 28, 2017. Jump up ^ Tolerable Upper Intake Levels For Vitamins And Minerals ( PDF ), European Food Safety Authority, 2006, archived ( PDF ) from the original on March 16, 2016 Jump up ^ `` Federal Register May 27, 2016 Food Labeling : Revision of the Nutrition and Supplement Facts Labels. FR page 33982 '' ( PDF ). Archived ( PDF ) from the original on August 8, 2016. Jump up ^ `` Changes to the Nutrition Facts Panel -- Compliance Date '' Archived March 12, 2017, at the Wayback Machine. Jump up ^ Ensminger, Audrey H. ; Konlande, James E. ( 1993 ). Foods & Nutrition Encyclopedia ( 2nd ed. ). Boca Raton, Florida : CRC Press. pp. 2368 -- 2369. ISBN 0 - 8493 - 8980 - 1. Jump up ^ `` Zinc content of selected foods per common measure '' ( PDF ). USDA National Nutrient Database for Standard Reference, Release 20. United States Department of Agriculture. Archived from the original on March 5, 2009. Retrieved December 6, 2007. CS1 maint : BOT : original - url status unknown ( link ) ^ Jump up to : Allen, Lindsay H. ( 1998 ). `` Zinc and micronutrient supplements for children ''. American Journal of Clinical Nutrition. 68 ( 2 Suppl ) : 495S -- 498S. PMID 9701167. Jump up ^ Rosado, J.L. ( 2003 ). `` Zinc and copper : proposed fortification levels and recommended zinc compounds ''. Journal of Nutrition. 133 ( 9 ) : 2985S -- 9S. doi : 10.1093 / jn / 133.9. 2985S. PMID 12949397. Jump up ^ Hotz, C. ; DeHaene, J. ; Woodhouse, L.R. ; Villalpando, S. ; Rivera, J.A. ; King, J.C. ( 2005 ). `` Zinc absorption from zinc oxide, zinc sulfate, zinc oxide + EDTA, or sodium - zinc EDTA does not differ when added as fortificants to maize tortillas ''. Journal of Nutrition. 135 ( 5 ) : 1102 -- 5. PMID 15867288. Jump up ^ Moshfegh, Alanna ; Goldman, Joseph ; and Cleveland, Linda. ( 2005 ). What We Eat in America Archived September 10, 2016, at the Wayback Machine... NHANES 2001 -- 2002 : Usual Nutrient Intakes from Food Compared to Dietary Reference Intakes. U.S. Department of Agriculture, Agricultural Research Service. Table A13 : Zinc. Jump up ^ What We Eat In America, NHANES 2013 -- 2014 Archived February 24, 2017, at the Wayback Machine... Jump up ^ NRC 2000, p. 442 Jump up ^ Ibs, K.H. ; Rink, L. ( 2003 ). `` Zinc - altered immune function ''. Journal of Nutrition. 133 ( 5 Suppl 1 ) : 1452S -- 6S. PMID 12730441. ^ Jump up to : `` Position of the American Dietetic Association and Dietitians of Canada : Vegetarian diets '' ( PDF ). Journal of the American Dietetic Association. 103 ( 6 ) : 748 -- 65. 2003. doi : 10.1053 / jada. 2003.50142. PMID 12778049. Archived ( PDF ) from the original on January 14, 2017. Jump up ^ Freeland - Graves J.H. ; Bodzy P.W. ; Epright M.A. ( 1980 ). `` Zinc status of vegetarians ''. Journal of the American Dietetic Association. 77 ( 6 ) : 655 -- 661. PMID 7440860. Jump up ^ Hambidge, M. ( 2003 ). `` Biomarkers of trace mineral intake and status ''. Journal of Nutrition. 133. 3 ( 3 ) : 948S -- 955S. PMID 12612181. ^ Jump up to : WHO contributors ( 2007 ). `` The impact of zinc supplementation on childhood mortality and severe morbidity ''. World Health Organization. Archived from the original on March 2, 2009. Retrieved March 1, 2009. Jump up ^ Shrimpton, R. ; Gross, R. ; Darnton - Hill, I. ; Young, M. ( 2005 ). `` Zinc deficiency : what are the most appropriate interventions ? ''. British Medical Journal. 330 ( 7487 ) : 347 -- 9. doi : 10.1136 / bmj. 330.7487. 347. PMC 548733. PMID 15705693. Jump up ^ Geoffrey Michael Gadd ( March 2010 ). `` Metals, minerals and microbes : geomicrobiology and bioremediation ''. Microbiology. 156 ( 3 ) : 609 -- 643. doi : 10.1099 / mic. 0.037143 - 0. PMID 20019082. Archived from the original on October 25, 2014. Jump up ^ Alloway, Brian J. ( 2008 ). `` Zinc in Soils and Crop Nutrition, International Fertilizer Industry Association, and International Zinc Association ''. Archived from the original on February 19, 2013. Jump up ^ Eisler, Ronald ( 1993 ). `` Zinc Hazard to Fish, Wildlife, and Invertebrates : A Synoptic Review '' ( PDF ). Contaminant Hazard Reviews. Laurel, Maryland : U.S. Department of the Interior, Fish and Wildlife Service ( 10 ). Archived from the original on March 6, 2012. CS1 maint : BOT : original - url status unknown ( link ) Jump up ^ Muyssen, Brita T.A. ; De Schamphelaere, Karel A.C. ; Janssen, Colin R. ( 2006 ). `` Mechanisms of chronic waterborne Zn toxicity in Daphnia magna ''. Aquatic Toxicology. 77 ( 4 ) : 393 -- 401. doi : 10.1016 / j. aquatox. 2006.01. 006. PMID 16472524. Jump up ^ Bothwell, Dawn N. ; Mair, Eric A. ; Cable, Benjamin B. ( 2003 ). `` Chronic Ingestion of a Zinc - Based Penny ''. Pediatrics. 111 ( 3 ) : 689 -- 91. doi : 10.1542 / peds. 111.3. 689. PMID 12612262. Jump up ^ Johnson AR ; Munoz A ; Gottlieb JL ; Jarrard DF ( 2007 ). `` High dose zinc increases hospital admissions due to genitourinary complications ''. J. Urol. 177 ( 2 ) : 639 -- 43. doi : 10.1016 / j. juro. 2006.09. 047. PMID 17222649. Jump up ^ `` Lawsuits blame denture adhesives for neurological damage ''. Tampa Bay Times. February 15, 2010. Archived from the original on February 18, 2010. Jump up ^ Oxford, J.S. ; Öberg, Bo ( 1985 ). Conquest of viral diseases : a topical review of drugs and vaccines. Elsevier. p. 142. ISBN 0 - 444 - 80566 - 4. Jump up ^ `` FDA says Zicam nasal products harm sense of smell ''. Los Angeles Times. June 17, 2009. Archived from the original on June 21, 2012. Jump up ^ Lamore SD ; Cabello CM ; Wondrak GT ( 2010 ). `` The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP - dependent energy crisis in human skin cells ''. Cell Stress Chaperones. 15 ( 3 ) : 309 -- 22. doi : 10.1007 / s12192 - 009 - 0145 - 6. PMC 2866994. PMID 19809895. Jump up ^ Barceloux, Donald G. ; Barceloux, Donald ( 1999 ). `` Zinc ''. Clinical Toxicology. 37 ( 2 ) : 279 -- 292. doi : 10.1081 / CLT - 100102426. Jump up ^ Bennett, Daniel R.M.D. ; Baird, Curtis J.M.D. ; Chan, Kwok - Ming ; Crookes, Peter F. ; Bremner, Cedric G. ; Gottlieb, Michael M. ; Naritoku, Wesley Y.M.D. ( 1997 ). `` Zinc Toxicity Following Massive Coin Ingestion ''. American Journal of Forensic Medicine and Pathology. 18 ( 2 ) : 148 -- 153. doi : 10.1097 / 00000433 - 199706000 - 00008. Jump up ^ Fernbach, S.K. ; Tucker G.F. ( 1986 ). `` Coin ingestion : unusual appearance of the penny in a child ''. Radiology. 158 ( 2 ) : 512. doi : 10.1148 / radiology. 158.2. 3941880. PMID 3941880. Jump up ^ Stowe, C.M. ; Nelson, R. ; Werdin, R. ; Fangmann, G. ; Fredrick, P. ; Weaver, G. ; Arendt, T.D. ( 1978 ). `` Zinc phosphide poisoning in dogs ''. Journal of the American Veterinary Medical Association. 173 ( 3 ) : 270. PMID 689968. Jump up ^ Reece, R.L. ; Dickson, D.B. ; Burrowes, P.J. ( 1986 ). `` Zinc toxicity ( new wire disease ) in aviary birds ''. Australian Veterinary Journal. 63 ( 6 ) : 199. doi : 10.1111 / j. 1751 - 0813.1986. tb02979. x. Bibliography Chambers, William and Robert ( 1901 ). Chambers 's Encyclopaedia : A Dictionary of Universal Knowledge ( Revised ed. ). London and Edinburgh : J.B. Lippincott Company. Cotton, F. Albert ; Wilkinson, Geoffrey ; Murillo, Carlos A. ; Bochmann, Manfred ( 1999 ). Advanced Inorganic Chemistry ( 6th ed. ). New York : John Wiley & Sons, Inc. ISBN 0 - 471 - 19957 - 5. CRC contributors ( 2006 ). David R. Lide, ed. Handbook of Chemistry and Physics ( 87th ed. ). Boca Raton, Florida : CRC Press, Taylor & Francis Group. ISBN 0 - 8493 - 0487 - 3. Emsley, John ( 2001 ). `` Zinc ''. Nature 's Building Blocks : An A-Z Guide to the Elements. Oxford, England, UK : Oxford University Press. pp. 499 -- 505. ISBN 0 - 19 - 850340 - 7. Greenwood, N.N. ; Earnshaw, A. ( 1997 ). Chemistry of the Elements ( 2nd ed. ). Oxford : Butterworth - Heinemann. ISBN 0 - 7506 - 3365 - 4. Heiserman, David L. ( 1992 ). `` Element 30 : Zinc ''. Exploring Chemical Elements and their Compounds. New York : TAB Books. ISBN 0 - 8306 - 3018 - X. Lehto, R.S. ( 1968 ). `` Zinc ''. In Clifford A. Hampel. The Encyclopedia of the Chemical Elements. New York : Reinhold Book Corporation. pp. 822 -- 830. ISBN 0 - 442 - 15598 - 0. LCCN 68 - 29938. United States National Research Council, Institute of Medicine ( 2000 ). Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academies Press. pp. 442 -- 455. Stwertka, Albert ( 1998 ). `` Zinc ''. Guide to the Elements ( Revised ed. ). Oxford University Press. ISBN 0 - 19 - 508083 - 1. Weeks, Mary Elvira ( 1933 ). `` III. Some Eighteenth - Century Metals ''. The Discovery of the Elements. Easton, PA : Journal of Chemical Education. ISBN 0 - 7661 - 3872 - 0. External links Listen to this article ( info / dl ) This audio file was created from a revision of the article `` Zinc '' dated 2012 - 01 - 25, and does not reflect subsequent edits to the article. ( Audio help ) More spoken articles Wikimedia Commons has media related to Zinc. Look up zinc in Wiktionary, the free dictionary. Zinc Fact Sheet from the U.S. National Institutes of Health History & Etymology of Zinc Statistics and Information from the U.S. Geological Survey Reducing Agents > Zinc American Zinc Association Information about the uses and properties of zinc. Outline safety data for zinc ISZB International Society for Zinc Biology, founded in 2008. An international, nonprofit organization bringing together scientists working on the biological actions of zinc. Zinc - UK Founded in 2010 to bring together scientists in the United Kingdom working on zinc. Zinc at The Periodic Table of Videos ( University of Nottingham ) Periodic table ( Large cells ) 5 6 7 8 9 10 11 12 13 14 15 16 17 18 He Li Be O Ne Na Mg Al Si Cl Ar Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr 5 Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te Xe 6 Cs Ba La Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu Hf Ta Re Os Ir Pt Au Hg Tl Pb Bi Po At Rn 7 Fr Ra Ac Th Pa U Np Pu Am Cm Bk Cf Es Fm Md No Lr Rf Db Sg Bh Hs Mt Ds Rg Cn Nh Fl Mc Lv Ts Og Alkali metal Alkaline earth metal Lanthanide Actinide Transition metal Post - ​ transition metal Metalloid Reactive nonmetal Noble gas Unknown chemical properties Zinc compounds Zinc ( I ) Organozinc ( I ) compounds Zn ( C ( CH ) ) Zinc ( II ) ZnBr Zn ( CN ) ZnCl Zn ( ClO ) ZnCrO ZnF ZnH ZnI ZnMoO Zn ( NO ) ZnO ZnO Zn ( OH ) ZnS ZnSO ZnSe ZnTe Zn P O Zn Sb Zn As Zn N Zn P Zn ( PO ) Organozinc ( II ) compounds Zn ( CH ) Zn ( C H ) Zn ( CH ( CH ) ) Zn ( C ( CH ) ) Zn ( C H ) ZnCIH I Ionotropic glutamate receptor modulators AMPAR Agonists : Main site agonists : 5 - Fluorowillardiine Acromelic acid ( acromelate ) AMPA BOAA Domoic acid Glutamate Ibotenic acid Proline Quisqualic acid Willardiine ; Positive allosteric modulators : Aniracetam Cyclothiazide CX - 516 CX - 546 CX - 614 Farampator ( CX - 691, ORG - 24448 ) CX - 717 CX - 1739 CX - 1942 Diazoxide Hydrochlorothiazide ( HCTZ ) IDRA - 21 LY - 392098 LY - 395153 LY - 404187 LY - 451646 LY - 503430 Mibampator ( LY - 451395 ) Nooglutyl ORG - 26576 Oxiracetam PEPA PF - 04958242 Piracetam Pramiracetam S - 18986 Tulrampator ( S - 47445, CX - 1632 ) Antagonists : ACEA - 1011 ATPO Becampanel Caroverine CNQX Dasolampanel DNQX Fanapanel ( MPQX ) GAMS Kaitocephalin Kynurenic acid Kynurenine Licostinel ( ACEA - 1021 ) NBQX PNQX Selurampanel Tezampanel Theanine Topiramate YM90K Zonampanel ; Negative allosteric modulators : Barbiturates ( e.g., pentobarbital, sodium thiopental ) Cyclopropane Enflurane Ethanol ( alcohol ) Evans blue GYKI - 52466 GYKI - 53655 Halothane Irampanel Isoflurane Perampanel Pregnenolone sulfate Sevoflurane Talampanel ; Unknown / unsorted antagonists : Minocycline KAR Agonists : Main site agonists : 5 - Bromowillardiine 5 - Iodowillardiine Acromelic acid ( acromelate ) AMPA ATPA Domoic acid Glutamate Ibotenic acid Kainic acid LY - 339434 Proline Quisqualic acid SYM - 2081 ; Positive allosteric modulators : Cyclothiazide Diazoxide Enflurane Halothane Isoflurane Antagonists : ACEA - 1011 CNQX Dasolampanel DNQX GAMS Kaitocephalin Kynurenic acid Licostinel ( ACEA - 1021 ) LY - 382884 NBQX NS102 Selurampanel Tezampanel Theanine Topiramate UBP - 302 ; Negative allosteric modulators : Barbiturates ( e.g., pentobarbital, sodium thiopental ) Enflurane Ethanol ( alcohol ) Evans blue NS - 3763 Pregnenolone sulfate NMDAR Agonists : Main site agonists : AMAA Aspartate Glutamate Homocysteic acid ( L - HCA ) Homoquinolinic acid Ibotenic acid NMDA Proline Quinolinic acid Tetrazolylglycine Theanine ; Glycine site agonists : β - Fluoro - D - alanine ACBD ACC ( ACPC ) ACPD AK - 51 Apimostinel ( NRX - 1074 ) B6B21 CCG D - Alanine D - Cycloserine D - Serine DHPG Dimethylglycine Glycine HA - 966 L - 687414 L - Alanine L - Serine Milacemide Neboglamine ( nebostinel ) Rapastinel ( GLYX - 13 ) Sarcosine ; Polyamine site agonists : Neomycin Spermidine Spermine ; Other positive allosteric modulators : 24S - Hydroxycholesterol DHEA ( prasterone ) DHEA sulfate ( prasterone sulfate ) Epipregnanolone sulfate Pregnenolone sulfate SAGE - 201 SAGE - 301 SAGE - 718 Antagonists : Competitive antagonists : AP5 ( APV ) AP7 CGP - 37849 CGP - 39551 CGP - 39653 CGP - 40116 CGS - 19755 CPP Kaitocephalin LY - 233053 LY - 235959 LY - 274614 MDL - 100453 Midafotel ( d - CPPene ) NPC - 12626 NPC - 17742 PBPD PEAQX Perzinfotel PPDA SDZ - 220581 Selfotel ; Glycine site antagonists : 4 - Cl - KYN ( AV - 101 ) 5, 7 - DCKA 7 - CKA ACC ACEA - 1011 ACEA - 1328 Apimostinel ( NRX - 1074 ) AV - 101 Carisoprodol CGP - 39653 CNQX D - Cycloserine DNQX Felbamate Gavestinel GV - 196771 Harkoseride Kynurenic acid Kynurenine L - 689560 L - 701324 Licostinel ( ACEA - 1021 ) LU - 73068 MDL - 105519 Meprobamate MRZ 2 / 576 PNQX Rapastinel ( GLYX - 13 ) ZD - 9379 ; Polyamine site antagonists : Arcaine Co 101676 Diaminopropane Diethylenetriamine Huperzine A Putrescine ; Uncompetitive pore blockers ( mostly dizocilpine site ) : 2 - MDP 3 - HO - PCP 3 - MeO - PCE 3 - MeO - PCMo 3 - MeO - PCP 4 - MeO - PCP 8A - PDHQ 18 - MC α - Endopsychosin Alaproclate Alazocine ( SKF - 10047 ) Amantadine Aptiganel Argiotoxin - 636 Arketamine ARL - 12495 ARL - 15896 - AR ARL - 16247 Budipine Coronaridine Delucemine ( NPS - 1506 ) Dexoxadrol Dextrallorphan Dextromethadone Dextromethorphan Dextrorphan Dieticyclidine Diphenidine Dizocilpine Ephenidine Esketamine Etoxadrol Eticyclidine Fluorolintane Gacyclidine Ibogaine Ibogamine Indantadol Ketamine Ketobemidone Lanicemine Levomethadone Levomethorphan Levomilnacipran Levorphanol Loperamide Memantine Methadone Methorphan Methoxetamine Methoxphenidine Milnacipran Morphanol NEFA Neramexane Nitromemantine Noribogaine Norketamine Orphenadrine PCPr PD - 137889 Pethidine ( meperidine ) Phencyclamine Phencyclidine Propoxyphene Remacemide Rhynchophylline Rimantadine Rolicyclidine Sabeluzole Tabernanthine Tenocyclidine Tiletamine Tramadol ; Ifenprodil ( NR2B ) site antagonists : Besonprodil Buphenine ( nylidrin ) CO-101244 ( PD - 174494 ) Eliprodil Haloperidol Isoxsuprine Radiprodil ( RGH - 896 ) Rislenemdaz ( CERC - 301, MK - 0657 ) Ro 8 - 4304 Ro 25 - 6981 Safaprodil Traxoprodil ( CP - 101606 ) ; NR2A - selective antagonists : MPX - 004 MPX - 007 TCN - 201 TCN - 213 ; Cations : Hydrogen Magnesium Zinc ; Alcohols / volatile anesthetics / related : Benzene Butane Chloroform Cyclopropane Desflurane Diethyl ether Enflurane Ethanol ( alcohol ) Halothane Hexanol Isoflurane Methoxyflurane Nitrous oxide Octanol Sevoflurane Toluene Trichloroethane Trichloroethanol Trichloroethylene Urethane Xenon Xylene ; Unknown / unsorted antagonists : ARR - 15896 Bumetanide Caroverine Conantokin D - αAA Dexanabinol Flufenamic acid Flupirtine FPL - 12495 FR - 115427 Furosemide Hodgkinsine Ipenoxazone ( MLV - 6976 ) MDL - 27266 Metaphit Minocycline MPEP Niflumic acid Pentamidine Pentamidine isethionate Piretanide Psychotridine Transcrocetin ( saffron ) See also : Receptor / signaling modulators Metabotropic glutamate receptor modulators Glutamate metabolism / transport modulators BNE : XX529698 BNF : cb119731249 ( data ) GND : 4137453 - 8 LCCN : sh85149842 NDL : 00560063 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Zinc&oldid=843219581 '' Categories : Zinc Alchemical substances Biology and pharmacology of chemical elements Chemical elements Dietary minerals Post-transition metals Pyrotechnic fuels Reducing agents Hidden categories : CS1 maint : BOT : original - url status unknown CS1 German - language sources ( de ) Webarchive template wayback links Wikipedia indefinitely move - protected pages Use mdy dates from May 2015 Articles with short description Articles containing German - language text Articles containing Persian - language text Spoken articles Articles with hAudio microformats Featured articles Wikipedia articles with BNF identifiers Wikipedia articles with GND identifiers Wikipedia articles with LCCN identifiers Talk Contents About Wikipedia Afrikaans አማርኛ Aragonés Armãneashti অসমীয়া Asturianu Azərbaycanca تۆرکجه বাংলা Bân - lâm - gú Башҡортса Беларуская Беларуская ( тарашкевіца ) ‎ भोजपुरी Български བོད ་ ཡིག Bosanski Brezhoneg Català Чӑвашла Čeština ChiShona Corsu Cymraeg Dansk Deutsch ދިވެހިބަސް Eesti Ελληνικά Эрзянь Español Esperanto Euskara فارسی Fiji Hindi Føroyskt Français Frysk Furlan Gaeilge Gaelg Gàidhlig Galego Gĩkũyũ ગુજરાતી 客家 語 / Hak - kâ - ngî Хальмг 한국어 Հայերեն हिन्दी Hornjoserbsce Hrvatski Ido Bahasa Indonesia Interlingua Íslenska Italiano עברית Basa Jawa ಕನ್ನಡ ქართული Қазақша Kiswahili Коми Kreyòl ayisyen Kurdî Кыргызча Кырык мары Лакку Latina Latviešu Lëtzebuergesch Lietuvių Ligure Limburgs Livvinkarjala La. lojban. 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Question: where is zinc located on the periodic table
Answer: first element in group 12 of the periodic table