Nucleotide - wikipedia Nucleotide This nucleotide contains the five - carbon sugar deoxyribose ( at center ), a nitrogenous base called adenine ( upper right ), and one phosphate group ( left ). The deoxyribose sugar joined only to the nitrogenous base forms a Deoxyribonucleoside called deoxyadenosine, whereas the whole structure along with the phosphate group is a nucleotide, a constituent of DNA with the name deoxyadenosine monophosphate. Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid ( DNA ) and ribonucleic acid ( RNA ), both of which are essential biomolecules in all life - forms on Earth. Nucleotides are the building blocks of nucleic acids ; they are composed of three subunit molecules : a nitrogenous base, a five - carbon sugar ( ribose or deoxyribose ), and at least one phosphate group. They are also known as phosphate nucleotides. A nucleoside is a nitrogenous base and a 5 - carbon sugar. Thus a nucleoside plus a phosphate group yields a nucleotide. Nucleotides also play a central role in life - form metabolism at the fundamental, cellular level. They carry packets of chemical energy -- in the form of the nucleoside triphosphates ATP, GTP, CTP and UTP -- throughout the cell to the many cellular functions that demand energy, which include synthesizing amino acids, proteins and cell membranes and parts ; moving the cell and moving cell parts, both internally and intercellularly ; dividing the cell, etc. In addition, nucleotides participate in cell signaling ( cGMP and cAMP ), and are incorporated into important cofactors of enzymatic reactions ( e.g. coenzyme A, FAD, FMN, NAD, and NADP ). In experimental biochemistry, nucleotides can be radiolabeled with radionuclides to yield radionucleotides. Contents 1 Structure 2 Synthesis 2.1 Pyrimidine ribonucleotide synthesis 2.2 Purine ribonucleotide synthesis 2.3 Pyrimidine and purine degradation 3 Unnatural base pair ( UBP ) 4 Length unit 5 Nucleotide supplements 6 Abbreviation codes for degenerate bases 7 See also 8 References 9 Further reading 10 External links Structure Showing the arrangement of nucleotides within the structure of nucleic acids : At lower left, a monophosphate nucleotide ; its nitrogenous base represents one side of a base - pair. At upper right, four nucleotides form two base - pairs : thymine and adenine ( connected by double hydrogen bonds ) and guanine and cytosine ( connected by triple hydrogen bonds ). The individual nucleotide monomers are chain - joined at their sugar and phosphate molecules, forming two ' backbones ' ( a double helix ) of a nucleic acid, shown at upper left. A nucleotide is composed of three distinctive chemical sub-units : a five - carbon sugar molecule, a nitrogenous base -- which two together are called a nucleoside -- and one phosphate group. With all three joined, a nucleotide is also termed a `` nucleoside monophosphate ''. The chemistry sources ACS Style Guide and IUPAC Gold Book prescribe that a nucleotide should contain only one phosphate group, but common usage in molecular biology textbooks often extends the definition to include molecules with two, or with three, phosphates. Thus, the terms `` nucleoside diphosphate '' or `` nucleoside triphosphate '' may also indicate nucleotides. Nucleotides contain either a purine or a pyrimidine base -- i.e., the nitrogenous base molecule, also known as a nucleobase -- and are termed ribonucleotides if the sugar is ribose, or deoxyribonucleotides if the sugar is deoxyribose. Individual phosphate molecules repetitively connect the sugar - ring molecules in two adjacent nucleotide monomers, thereby connecting the nucleotide monomers of a nucleic acid end - to - end into a long chain. These chain - joins of sugar and phosphate molecules create a ' backbone ' strand for a single - or double helix. In any one strand, the chemical orientation ( directionality ) of the chain - joins runs from the 5 ' - end to the 3 ' - end ( read : 5 prime - end to 3 prime - end ) -- referring to the five carbon sites on sugar molecules in adjacent nucleotides. In a double helix, the two strands are oriented in opposite directions, which permits base pairing and complementarity between the base - pairs, all which is essential for replicating or transcribing the encoded information found in DNA. Unlike in nucleic acid nucleotides, singular cyclic nucleotides are formed when the phosphate group is bound twice to the same sugar molecule, i.e., at the corners of the sugar hydroxyl groups. These individual nucleotides function in cell metabolism rather than the nucleic acid structures of long - chain molecules. Nucleic acids then are polymeric macromolecules assembled from nucleotides, the monomer - units of nucleic acids. The purine bases adenine and guanine and pyrimidine base cytosine occur in both DNA and RNA, while the pyrimidine bases thymine ( in DNA ) and uracil ( in RNA ) in just one. Adenine forms a base pair with thymine with two hydrogen bonds, while guanine pairs with cytosine with three hydrogen bonds. Structural elements of three nucleotides -- where one -, two - or three - phosphates are attached to the nucleoside ( in yellow, blue, green ) at center : 1st, the nucleotide termed as a nucleoside monophosphate is formed by adding a phosphate group ( in red ) ; 2nd, adding a second phosphate group forms a nucleoside diphosphate ; 3rd, adding a third phosphate group results in a nucleoside triphosphate. + The nitrogenous base ( nucleobase ) is indicated by `` Base '' and `` glycosidic bond '' ( sugar bond ). All five primary, or canonical, bases -- the purines and pyrimidines -- are sketched at right ( in blue ). Synthesis Nucleotides can be synthesized by a variety of means both in vitro and in vivo. In vivo, nucleotides can be synthesized de novo or recycled through salvage pathways. The components used in de novo nucleotide synthesis are derived from biosynthetic precursors of carbohydrate and amino acid metabolism, and from ammonia and carbon dioxide. The liver is the major organ of de novo synthesis of all four nucleotides. De novo synthesis of pyrimidines and purines follows two different pathways. Pyrimidines are synthesized first from aspartate and carbamoyl - phosphate in the cytoplasm to the common precursor ring structure orotic acid, onto which a phosphorylated ribosyl unit is covalently linked. Purines, however, are first synthesized from the sugar template onto which the ring synthesis occurs. For reference, the syntheses of the purine and pyrimidine nucleotides are carried out by several enzymes in the cytoplasm of the cell, not within a specific organelle. Nucleotides undergo breakdown such that useful parts can be reused in synthesis reactions to create new nucleotides. In vitro, protecting groups may be used during laboratory production of nucleotides. A purified nucleoside is protected to create a phosphoramidite, which can then be used to obtain analogues not found in nature and / or to synthesize an oligonucleotide. Pyrimidine ribonucleotide synthesis The synthesis of UMP. The color scheme is as follows : enzymes, coenzymes, substrate names, inorganic molecules Main article : Pyrimidine metabolism The synthesis of the pyrimidines CTP and UTP occurs in the cytoplasm and starts with the formation of carbamoyl phosphate from glutamine and CO. Next, aspartate carbamoyltransferase catalyzes a condensation reaction between aspartate and carbamoyl phosphate to form carbamoyl aspartic acid, which is cyclized into 4, 5 - dihydroorotic acid by dihydroorotase. The latter is converted to orotate by dihydroorotate oxidase. The net reaction is : ( S ) - Dihydroorotate + O → Orotate + H O Orotate is covalently linked with a phosphorylated ribosyl unit. The covalent linkage between the ribose and pyrimidine occurs at position C of the ribose unit, which contains a pyrophosphate, and N of the pyrimidine ring. Orotate phosphoribosyltransferase ( PRPP transferase ) catalyzes the net reaction yielding orotidine monophosphate ( OMP ) : Orotate + 5 - Phospho - α - D - ribose 1 - diphosphate ( PRPP ) → Orotidine 5 ' - phosphate + Pyrophosphate Orotidine 5 ' - monophosphate is decarboxylated by orotidine - 5 ' - phosphate decarboxylase to form uridine monophosphate ( UMP ). PRPP transferase catalyzes both the ribosylation and decarboxylation reactions, forming UMP from orotic acid in the presence of PRPP. It is from UMP that other pyrimidine nucleotides are derived. UMP is phosphorylated by two kinases to uridine triphosphate ( UTP ) via two sequential reactions with ATP. First the diphosphate form UDP is produced, which in turn is phosphorylated to UTP. Both steps are fueled by ATP hydrolysis : ATP + UMP → ADP + UDP UDP + ATP → UTP + ADP CTP is subsequently formed by amination of UTP by the catalytic activity of CTP synthetase. Glutamine is the NH donor and the reaction is fueled by ATP hydrolysis, too : UTP + Glutamine + ATP + H O → CTP + ADP + P Cytidine monophosphate ( CMP ) is derived from cytidine triphosphate ( CTP ) with subsequent loss of two phosphates. Purine ribonucleotide synthesis Main article : Purine metabolism The atoms that are used to build the purine nucleotides come from a variety of sources : The synthesis of IMP. The color scheme is as follows : enzymes, coenzymes, substrate names, metal ions, inorganic molecules The biosynthetic origins of purine ring atoms N arises from the amine group of Asp C and C originate from formate N and N are contributed by the amide group of Gln C, C and N are derived from Gly C comes from HCO ( CO ) The de novo synthesis of purine nucleotides by which these precursors are incorporated into the purine ring proceeds by a 10 - step pathway to the branch - point intermediate IMP, the nucleotide of the base hypoxanthine. AMP and GMP are subsequently synthesized from this intermediate via separate, two - step pathways. Thus, purine moieties are initially formed as part of the ribonucleotides rather than as free bases. Six enzymes take part in IMP synthesis. Three of them are multifunctional : GART ( reactions 2, 3, and 5 ) PAICS ( reactions 6, and 7 ) ATIC ( reactions 9, and 10 ) The pathway starts with the formation of PRPP. PRPS1 is the enzyme that activates R5P, which is formed primarily by the pentose phosphate pathway, to PRPP by reacting it with ATP. The reaction is unusual in that a pyrophosphoryl group is directly transferred from ATP to C of R5P and that the product has the α configuration about C1. This reaction is also shared with the pathways for the synthesis of Trp, His, and the pyrimidine nucleotides. Being on a major metabolic crossroad and requiring much energy, this reaction is highly regulated. In the first reaction unique to purine nucleotide biosynthesis, PPAT catalyzes the displacement of PRPP 's pyrophosphate group ( PP ) by an amide nitrogen donated from either glutamine ( N ), glycine ( N&C ), aspartate ( N ), folic acid ( C ), or CO. This is the committed step in purine synthesis. The reaction occurs with the inversion of configuration about ribose C, thereby forming β - 5 - phosphorybosylamine ( 5 - PRA ) and establishing the anomeric form of the future nucleotide. Next, a glycine is incorporated fueled by ATP hydrolysis and the carboxyl group forms an amine bond to the NH previously introduced. A one - carbon unit from folic acid coenzyme N - formyl - THF is then added to the amino group of the substituted glycine followed by the closure of the imidazole ring. Next, a second NH group is transferred from a glutamine to the first carbon of the glycine unit. A carboxylation of the second carbon of the glycin unit is concomittantly added. This new carbon is modified by the additional of a third NH unit, this time transferred from an aspartate residue. Finally, a second one - carbon unit from formyl - THF is added to the nitrogen group and the ring covalently closed to form the common purine precursor inosine monophosphate ( IMP ). Inosine monophosphate is converted to adenosine monophosphate in two steps. First, GTP hydrolysis fuels the addition of aspartate to IMP by adenylosuccinate synthase, substituting the carbonyl oxygen for a nitrogen and forming the intermediate adenylosuccinate. Fumarate is then cleaved off forming adenosine monophosphate. This step is catalyzed by adenylosuccinate lyase. Inosine monophosphate is converted to guanosine monophosphate by the oxidation of IMP forming xanthylate, followed by the insertion of an amino group at C. NAD is the electron acceptor in the oxidation reaction. The amide group transfer from glutamine is fueled by ATP hydrolysis. Pyrimidine and purine degradation In humans, pyrimidine rings ( C, T, U ) can be degraded completely to CO and NH ( urea excretion ). That having been said, purine rings ( G, A ) can not. Instead they are degraded to the metabolically inert uric acid which is then excreted from the body. Uric acid is formed when GMP is split into the base guanine and ribose. Guanine is deaminated to xanthine which in turn is oxidized to uric acid. This last reaction is irreversible. Similarly, uric acid can be formed when AMP is deaminated to IMP from which the ribose unit is removed to form hypoxanthine. Hypoxanthine is oxidized to xanthine and finally to uric acid. Instead of uric acid secretion, guanine and IMP can be used for recycling purposes and nucleic acid synthesis in the presence of PRPP and aspartate ( NH donor ). Unnatural base pair ( UBP ) Main article : Base pair § Unnatural base pair ( UBP ) An unnatural base pair ( UBP ) is a designed subunit ( or nucleobase ) of DNA which is created in a laboratory and does not occur in nature. In 2012, a group of American scientists led by Floyd Romesberg, a chemical biologist at the Scripps Research Institute in San Diego, California, published that his team designed an unnatural base pair ( UBP ). The two new artificial nucleotides or Unnatural Base Pair ( UBP ) were named d5SICS and dNaM. More technically, these artificial nucleotides bearing hydrophobic nucleobases, feature two fused aromatic rings that form a ( d5SICS -- dNaM ) complex or base pair in DNA. In 2014 the same team from the Scripps Research Institute reported that they synthesized a stretch of circular DNA known as a plasmid containing natural T-A and C-G base pairs along with the best - performing UBP Romesberg 's laboratory had designed, and inserted it into cells of the common bacterium E. coli that successfully replicated the unnatural base pairs through multiple generations. This is the first known example of a living organism passing along an expanded genetic code to subsequent generations. This was in part achieved by the addition of a supportive algal gene that expresses a nucleotide triphosphate transporter which efficiently imports the triphosphates of both d5SICSTP and dNaMTP into E. coli bacteria. Then, the natural bacterial replication pathways use them to accurately replicate the plasmid containing d5SICS -- dNaM. The successful incorporation of a third base pair is a significant breakthrough toward the goal of greatly expanding the number of amino acids which can be encoded by DNA, from the existing 21 amino acids to a theoretically possible 172, thereby expanding the potential for living organisms to produce novel proteins. The artificial strings of DNA do not encode for anything yet, but scientists speculate they could be designed to manufacture new proteins which could have industrial or pharmaceutical uses. Length unit Nucleotide ( abbreviated `` nt '' ) is a common unit of length for single - stranded nucleic acids, similar to how base pair is a unit of length for double - stranded nucleic acids. Nucleotide supplements A study done by the Department of Sports Science at the University of Hull in Hull, UK has shown that nucleotides have significant impact on cortisol levels in saliva. Post exercise, the experimental nucleotide group had lower cortisol levels in their blood than the control or the placebo. Additionally, post supplement values of Immunoglobulin A were significantly higher than either the placebo or the control. The study concluded, `` nucleotide supplementation blunts the response of the hormones associated with physiological stress. '' Another study conducted in 2013 looked at the impact nucleotide supplementation had on the immune system in athletes. In the study, all athletes were male and were highly skilled in taekwondo. Out of the twenty athletes tested, half received a placebo and half received 480 mg per day of nucleotide supplement. After thirty days, the study concluded that nucleotide supplementation may counteract the impairment of the body 's immune function after heavy exercise. Abbreviation codes for degenerate bases Main article : Nucleic acid notation The IUPAC has designated the symbols for nucleotides. Apart from the five ( A, G, C, T / U ) bases, often degenerate bases are used especially for designing PCR primers. These nucleotide codes are listed here. Some primer sequences may also include the character `` I '', which codes for the non-standard nucleotide inosine. Inosine occurs in tRNAs, and will pair with adenine, cytosine, or thymine. This character does not appear in the following table however, because it does not represent a degeneracy. While inosine can serve a similar function as the degeneracy `` D '', it is an actual nucleotide, rather than a representation of a mix of nucleotides that covers each possible pairing needed. Symbol Description Bases represented adenine cytosine guanine thymine U uracil U weak strong amino keto purine Y pyrimidine not A ( B comes after A ) not C ( D comes after C ) not G ( H comes after G ) V not T ( V comes after T and U ) any base ( not a gap ) See also Molecular and cellular biology portal Biology Chromosome Gene Genetics Nucleic acid analogues Nucleic acid sequence Nucleobase References ^ Jump up to : Alberts B, Johnson A, Lewis J, Raff M, Roberts K & Walter P ( 2002 ). Molecular Biology of the Cell ( 4th ed. ). Garland Science. ISBN 0 - 8153 - 3218 - 1. pp. 120 -- 121. Jump up ^ Coghill, Anne M. ; Garson, Lorrin R., eds. ( 2006 ). The ACS style guide : effective communication of scientific information ( 3rd ed. ). Washington, D.C. : American Chemical Society. p. 244. ISBN 978 - 0 - 8412 - 3999 - 9. Jump up ^ `` Nucleotides ''. IUPAC Gold Book. International Union of Pure and Applied Chemists. doi : 10.1351 / goldbook. N04255. Retrieved 30 June 2014. Jump up ^ Lehninger, Albert L. ( 1975 ). Biochemistry : the molecular basis of cell structure and function. New York : Worth Publishers Inc. doi : 10.1002 / jobm. 19770170116. Jump up ^ Stryer, Lubert ( 1988 ). Biochemistry ( 3rd ed. ). New York : W.H. Freeman. ISBN 9780716719205. Jump up ^ Garrett, Reginald H. ; Grisham, Charles M. ( 2007 ). Biochemistry ( 4th ed. ). Belmont, California : Brooks / Cole, Cengage Learning. Jump up ^ Zaharevitz, DW ; Anerson, LW ; Manlinowski, NM ; Hyman, R ; Strong, JM ; Cysyk, RL. `` Contribution of de-novo and salvage synthesis to the uracil nucleotide pool in mouse tissues and tumors in vivo ''. Jump up ^ See IUPAC nomenclature of organic chemistry for details on carbon residue numbering Jump up ^ Jones, M.E. ( 1980 ). `` Pyrimidine nucleotide biosynthesis in animals : Genes, enzymes, and regulation of UMP biosynthesis ''. Annu. Rev. Biochem. 49 ( 1 ) : 253 -- 79. doi : 10.1146 / annurev. bi. 49.070180. 001345. PMID 6105839. Jump up ^ McMurry, JE ; Begley, TP ( 2005 ). The organic chemistry of biological pathways. Roberts & Company. ISBN 978 - 0 - 9747077 - 1 - 6. Jump up ^ Malyshev, Denis A. ; Dhami, Kirandeep ; Quach, Henry T. ; Lavergne, Thomas ; Ordoukhanian, Phillip ( 24 July 2012 ). `` Efficient and sequence - independent replication of DNA containing a third base pair establishes a functional six - letter genetic alphabet ''. Proceedings of the National Academy of Sciences of the United States of America. 109 ( 30 ) : 12005 -- 12010. Bibcode : 2012PNAS... 10912005M. doi : 10.1073 / pnas. 1205176109. PMC 3409741. PMID 22773812. Retrieved 2014 - 05 - 11. ^ Jump up to : Malyshev, Denis A. ; Dhami, Kirandeep ; Lavergne, Thomas ; Chen, Tingjian ; Dai, Nan ; Foster, Jeremy M. ; Corrêa, Ivan R. ; Romesberg, Floyd E. ( May 7, 2014 ). `` A semi-synthetic organism with an expanded genetic alphabet ''. Nature. 509 : 385 -- 8. doi : 10.1038 / nature13314. PMC 4058825. PMID 24805238. Retrieved May 7, 2014. Jump up ^ Callaway, Ewan ( May 7, 2014 ). `` Scientists Create First Living Organism With ' Artificial ' DNA ''. Nature News. Huffington Post. Retrieved 8 May 2014. ^ Jump up to : Fikes, Bradley J. ( May 8, 2014 ). `` Life engineered with expanded genetic code ''. San Diego Union Tribune. Retrieved 8 May 2014. Jump up ^ Sample, Ian ( May 7, 2014 ). `` First life forms to pass on artificial DNA engineered by US scientists ''. The Guardian. Retrieved 8 May 2014. Jump up ^ Pollack, Andrew ( May 7, 2014 ). `` Scientists Add Letters to DNA 's Alphabet, Raising Hope and Fear ''. New York Times. Retrieved 8 May 2014. Jump up ^ Mc Naughton, L. ; Bentley, D. ; Koeppel, P. ( 2007 - 03 - 01 ). `` The effects of a nucleotide supplement on the immune and metabolic response to short term, high intensity exercise performance in trained male subjects ''. The Journal of Sports Medicine and Physical Fitness. 47 ( 1 ) : 112 -- 118. ISSN 0022 - 4707. PMID 17369807. Jump up ^ Riera, Joan ; Pons, Victoria ; Martinez - Puig, Daniel ; Chetrit, Carlos ; Tur, Josep A. ; Pons, Antoni ; Drobnic, Franchek ( 2013 - 04 - 08 ). `` Dietary nucleotide improves markers of immune response to strenuous exercise under a cold environment ''. Journal of the International Society of Sports Nutrition. 10 ( 1 ) : 20. doi : 10.1186 / 1550 - 2783 - 10 - 20. PMC 3626726. PMID 23566489. ^ Jump up to : Nomenclature Committee of the International Union of Biochemistry ( NC - IUB ) ( 1984 ). `` Nomenclature for Incompletely Specified Bases in Nucleic Acid Sequences ''. Retrieved 2008 - 02 - 04. Further reading Sigel, Astrid ; Operschall, Bert P. ; Sigel, Helmut ( 2017 ). `` Chapter 11. Complex Formation of Lead ( II ) with Nucleotides and Their Constituents ''. In Astrid, S. ; Helmut, S. ; Sigel, R.K.O. Lead : Its Effects on Environment and Health. Metal Ions in Life Sciences. 17. de Gruyter. pp. 319 -- 402. doi : 10.1515 / 9783110434330 - 011. External links Abbreviations and Symbols for Nucleic Acids, Polynucleotides and their Constituents ( IUPAC ) Provisional Recommendations 2004 ( IUPAC ) Chemistry explanation of nucleotide structure Genetics Introduction Outline History Index Key components Chromosome DNA RNA Nucleotide Genome Fields Classical Conservation Ecological Immunogenetics Molecular Population Quantitative Archaeogenetics of the Americas the British Isles Europe Italy the Near East South Asia Related topics Behavioural genetics Epigenetics Geneticist Genomics Genetic code Medical genetics Molecular evolution Reverse genetics Genetic engineering Genetic diversity Heredity Genetic monitoring Genetic genealogy List of genetics research organizations Genetics Nucleic acid constituents Nucleobase Purine Adenine Guanine Hypoxanthine Xanthine Purine analogue Pyrimidine Uracil Thymine Cytosine Pyrimidine analogue Unnatural base pair ( UBP ) Nucleoside Ribonucleoside Adenosine Guanosine 5 - Methyluridine Uridine 5 - Methylcytidine Cytidine Inosine Xanthosine Wybutosine Deoxyribonucleoside Deoxyadenosine Deoxyguanosine Thymidine Deoxyuridine Deoxycytidine Deoxyinosine Deoxyxanthosine Nucleotide ( Nucleoside monophosphate ) Ribonucleotide AMP GMP m UMP UMP CMP IMP XMP Deoxyribonucleotide dAMP dGMP dTMP dUMP dCMP dIMP dXMP Cyclic nucleotide cAMP cGMP c - di - GMP cADPR Nucleoside diphosphate ADP GDP m UDP UDP CDP dADP dGDP dTDP dUDP dCDP Nucleoside triphosphate ATP GTP m UTP UTP CTP ITP XTP dATP dGTP dTTP dUTP dCTP dITP dXTP Purine receptor modulators Receptor ( ligands ) P0 ( adenine ) Agonists : 8 - Aminoadenine Adenine P1 ( adenosine ) Agonists : 2 - ( 1 - Hexynyl ) - N - methyladenosine 2 - Cl - IB - MECA 2 ' - MeCCPA 4 ' - O - β - D - Glucosyl - 9 - O - ( 6 ' ' - deoxysaccharosyl ) olivil 5 ' - N - ethylcarboxamidoadenosine Adenosine ADP AMP Apadenoson ATL - 146e ATP BAY 60 -- 6583 Binodenoson Capadenoson CCPA CGS - 21680 CP - 532,903 Evodenoson GR 79236 LUF - 5835 LUF - 5845 N - Cyclopentyladenosine Namodenoson Neladenoson dalanate Piclidenoson Regadenoson SDZ WAG 994 Selodenoson Sonedenoson Tecadenoson UK - 432,097 Antagonists : 8 - Chlorotheophylline 8 - Phenyl - 1, 3 - dipropylxanthine 8 - Phenyltheophylline Acefylline Aminophylline ATL - 444 Bamifylline Cafedrine Caffeine Caffeine citrate Cartazolate CGH - 2466 CGS - 15943 Choline theophyllinate CPX CVT - 6883 Dimethazan DMPX DPCPX Dyphylline Enprofylline Etazolate Fenethylline IBMX Isovaleric acid Istradefylline KF - 26777 MRE3008F20 MRS - 1220 MRS - 1334 MRS - 1706 MRS - 1754 MRS - 3777 Paraxanthine Pentoxifylline Preladenant Propentofylline Proxyphylline PSB - 10 PSB - 11 PSB - 36 PSB - 603 PSB - 788 PSB - 1115 Reversine Rolofylline SCH - 442,416 SCH - 58261 Theacrine Theobromine Theodrenaline Theophylline Tozadenant Tracazolate VUF - 5574 ZM - 241,385 P2 ( nucleotide ) P2X ( ATP ) Agonists : 2 - Me - SATP α, β - Me - ATP Adenosine ADP AMP Ap4A Ap5A ATP ATPγS BzATP Cibacron blue CTP D - β, γ - Me - ATP GTP HT - AMP Ivermectin L - β, γ - Me - ATP MRS - 2219 PAPET - ATP UTP Zinc Antagonists : 5 - BDBD A-317491 A-438079 A-740003 A-804598 A-839977 AF - 353 AZ - 10606120 AZ - 11645373 BBG Calcium Calmidazolium Chelerythrine Copper Emodin ( Rheum officinale ) Evans Blue GW - 791343 HMA Ip5I isoPPADS JNJ - 47965567 KN - 04 KN - 62 Magnesium MRS - 2159 NF - 023 NF - 110 NF - 157 NF - 279 NF - 449 Opiranserin ( VVZ - 149 ) Oxidized - ATP Phenol Red Phenolphthalein PPADS PPNDS PSB - 12062 Puerarin ( Radix puerariae ) Purotoxin 1 RB - 2 Ro 0437626 Ro 51 RO - 3 Sodium ferulate ( Angelica sinensis, Ligusticum wallichii ) Suramin TC - P 262 Tetramethylpyrazine ( ligustrazine ) ( Ligusticum wallichii ) TNP - ATP Zinc P2Y Agonists : 2 - Me - SADP 2 - Me - SATP 2 - Thio - UTP 5 - Br - UDP 5 - OMe - UDP α, β - Me - ATP Adenosine ADP ADPβS Ap3A AR - C 67085MX ATP ATPγS CTP dATP Denufosol Diquafosol IDP ITP INS - 365 INS - 37217 MRS - 2365 MRS - 2690 MRS - 2693 MRS - 2768 MRS - 2957 MRS - 4062 NF - 546 PAPET - ATP PSB - 0474 PSB - 1114 UDP UDPβS UDP - galactose UDP - glucose UDP - N - acetylglucosamine Up3U UTP UTPγS Antagonists : 2 - Me - SAMP A3P5PS AMPαS Ap4A AR - C 66096 AR - C 67085MX AR - C 69931MX AR - C 118925XX ATP BzATP C1330 - 7 Cangrelor Clopidogrel Elinogrel Ip5I MRS - 2179 MRS - 2211 MRS - 2279 MRS - 2395 MRS - 2500 MRS - 2578 NF - 157 NF - 340 PIT PPADS Prasugrel PSB - 0739 RB - 2 Regrelor Suramin Ticagrelor Ticlopidine UDP Transporter ( blockers ) CNTs 6 - Hydroxy - 7 - methoxyflavone Adenosine dMeThPmR Estradiol KGO - 2142 KGO - 2173 MeThPmR Phloridzin Progesterone ENTs Barbiturates Benzodiazepines Cilostazol Dilazep Dipyridamole Estradiol Ethanol Hexobendine NBMPR Pentoxifylline Progesterone Propentofylline PMAT Decynium - 22 Enzyme ( inhibitors ) XO Allopurinol Amflutizole Benzbromarone Caffeic acid Cinnamaldehyde Cinnamomum osmophloeum Febuxostat Myo - inositol Kaempferol Myricetin Niraxostat Oxipurinol Phytic acid Pistacia integerrima Propolis Quercetin Tisopurine Topiroxostat Others Aminopterin Azathioprine Methotrexate Mycophenolic acid Pemetrexed Pralatrexate Many others Others Precursors : Adenine Adenosine AMP ADP ATP Cytosine Cytidine CMP CDP CTP Guanine Guanosine GMP GDP GTP Hypoxanthine Inosine IMP IDP ITP Ribose Uracil Uridine UMP UDP UTP Others : Chrysophanol ( rhubarb ) See also : Receptor / signaling modulators NDL : 00568741 NKC : ph123363 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Nucleotide&oldid=824125987 '' Categories : Nucleotides Genetics DNA Molecular biology Hidden categories : Pages using div col without cols and colwidth parameters Talk Contents About Wikipedia Afrikaans Azərbaycanca বাংলা Bân - 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Question: what are the basic components of a nucleotide
Answer: a nitrogenous base, a five-carbon sugar (ribose or deoxyribose), and at least one phosphate group