Thyrotropin receptor - wikipedia Thyrotropin receptor Not to be confused with Thyrotropin - releasing hormone or Thyrotropin - releasing hormone receptor. TSHR Available structures PDB Ortholog search : PDBe RCSB List of PDB id codes 2XWT, 3G04 Identifiers Aliases TSHR, CHNG1, LGR3, hTSHR - I, thyroid stimulating hormone receptor, Thyrotropin receptor External IDs OMIM : 603372 MGI : 98849 HomoloGene : 315 GeneCards : TSHR Gene location ( Human ) Chr. Chromosome 14 ( human ) Band 14q31. 1 Start 80,954,989 bp End 81,146,302 bp Gene location ( Mouse ) Chr. Chromosome 12 ( mouse ) Band 12 D3 12 44.51 cM Start 91,384,563 bp End 91,549,808 bp RNA expression pattern More reference expression data Gene ontology Molecular function G - protein coupled peptide receptor activity protein binding G - protein coupled receptor activity protein - hormone receptor activity signal transducer activity receptor activity protein complex binding thyroid - stimulating hormone receptor activity Cellular component integral component of membrane receptor complex integral component of plasma membrane membrane cell surface plasma membrane basolateral plasma membrane intracellular Biological process cell - cell signaling G - protein coupled receptor signaling pathway G - protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase - activating G - protein coupled receptor signaling pathway positive regulation of cell proliferation activation of adenylate cyclase activity hormone - mediated signaling pathway signal transduction nervous system development cell surface receptor signaling pathway positive regulation of cAMP biosynthetic process positive regulation of adenylate cyclase activity cellular response to glycoprotein cellular response to thyrotropin - releasing hormone thyroid - stimulating hormone signaling pathway Sources : Amigo / QuickGO Orthologs Species Human Mouse Entrez 7253 22095 Ensembl ENSG00000165409 ENSMUSG00000020963 UniProt P16473 P47750 RefSeq ( mRNA ) NM_000369 NM_001018036 NM_001142626 NM_001113404 NM_011648 RefSeq ( protein ) NP_000360 NP_001018046 NP_001136098 NP_001106875 NP_035778 Location ( UCSC ) Chr 14 : 80.95 -- 81.15 Mb Chr 14 : 91.38 -- 91.55 Mb PubMed search Wikidata View / Edit Human View / Edit Mouse The thyrotropin receptor ( or TSH receptor ) is a receptor ( and associated protein ) that responds to thyroid - stimulating hormone ( also known as `` thyrotropin '' ) and stimulates the production of thyroxine ( T4 ) and triiodothyronine ( T3 ). The TSH receptor is a member of the G protein - coupled receptor superfamily of integral membrane proteins and is coupled to the G protein. It is primarily found on the surface of the thyroid epithelial cells, but also found on adipose tissue and fibroblasts. The latter explains the reason of the myxedema finding during Graves disease. Contents 1 Function 2 See also 3 References 4 Further reading 5 External links Function Upon binding circulating thyrotropin, a G - protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping ; thyroglobulin synthesis, iodination, endocytosis and proteolysis ; thyroid peroxidase activity ; and hormone release. See also Graves ' disease References ^ Jump up to : GRCh38 : Ensembl release 89 : ENSG00000165409 - Ensembl, May 2017 ^ Jump up to : GRCm38 : Ensembl release 89 : ENSMUSG00000020963 - Ensembl, May 2017 Jump up ^ `` Human PubMed Reference : ''. Jump up ^ `` Mouse PubMed Reference : ''. Jump up ^ Farid NR, Szkudlinski MW ( Sep 2004 ). `` Minireview : structural and functional evolution of the thyrotropin receptor ''. Endocrinology. 145 ( 9 ) : 4048 -- 57. PMID 15231707. doi : 10.1210 / en. 2004 - 0437. Jump up ^ Calebiro D, Nikolaev VO, Lohse MJ ( Jul 2010 ). `` Imaging of persistent cAMP signaling by internalized G protein - coupled receptors ''. Journal of Molecular Endocrinology. 45 ( 1 ) : 1 -- 8. PMID 20378719. doi : 10.1677 / JME - 10 - 0014. Further reading Führer D, Wonerow P, Willgerodt H, Paschke R ( Dec 1997 ). `` Identification of a new thyrotropin receptor germline mutation ( Leu629Phe ) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism ''. The Journal of Clinical Endocrinology and Metabolism. 82 ( 12 ) : 4234 -- 8. PMID 9398746. doi : 10.1210 / jc. 82.12. 4234. Farid NR, Kascur V, Balazs C ( Jul 2000 ). `` The human thyrotropin receptor is highly mutable : a review of gain - of - function mutations ''. European Journal of Endocrinology / European Federation of Endocrine Societies. 143 ( 1 ) : 25 -- 30. PMID 10870027. doi : 10.1530 / eje. 0.1430025. Szkudlinski MW, Fremont V, Ronin C, Weintraub BD ( Apr 2002 ). `` Thyroid - stimulating hormone and thyroid - stimulating hormone receptor structure - function relationships ''. Physiological Reviews. 82 ( 2 ) : 473 -- 502. PMID 11917095. doi : 10.1152 / physrev. 00031.2001. Tonacchera M, Vitti P, De Servi M, Agretti P, De Marco G, Chiovato L, Pinchera A ( 2004 ). `` Gain of function TSH receptor mutations and iodine deficiency : implications in iodine prophylaxis ''. Journal of Endocrinological Investigation. 26 ( 2 Suppl ) : 2 -- 6. PMID 12762632. Arturi F, Scarpelli D, Coco A, Sacco R, Bruno R, Filetti S, Russo D ( Apr 2003 ). `` Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery : unresolved questions ''. Thyroid. 13 ( 4 ) : 341 -- 3. PMID 12804102. doi : 10.1089 / 105072503321669811. Vaidya B, Campbell V, Tripp JH, Spyer G, Hattersley AT, Ellard S ( Jun 2004 ). `` Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation ''. Clinical Endocrinology. 60 ( 6 ) : 711 -- 8. PMID 15163335. doi : 10.1111 / j. 1365 - 2265.2004. 02040. x. Takeshita A, Nagayama Y, Fujiyama K, Yokoyama N, Namba H, Yamashita S, Izumi M, Nagataki S ( Nov 1992 ). `` Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript ''. Biochemical and Biophysical Research Communications. 188 ( 3 ) : 1214 -- 9. PMID 1445355. doi : 10.1016 / 0006 - 291X ( 92 ) 91360 - 3. Graves PN, Tomer Y, Davies TF ( Sep 1992 ). `` Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain ''. Biochemical and Biophysical Research Communications. 187 ( 2 ) : 1135 -- 43. PMID 1530609. doi : 10.1016 / 0006 - 291X ( 92 ) 91315 - H. Loosfelt H, Pichon C, Jolivet A, Misrahi M, Caillou B, Jamous M, Vannier B, Milgrom E ( May 1992 ). `` Two - subunit structure of the human thyrotropin receptor ''. Proceedings of the National Academy of Sciences of the United States of America. 89 ( 9 ) : 3765 -- 9. PMC 525571. PMID 1570295. doi : 10.1073 / pnas. 89.9. 3765. Nagayama Y, Russo D, Wadsworth HL, Chazenbalk GD, Rapoport B ( Aug 1991 ). `` Eleven amino acids ( Lys - 201 to Lys - 211 ) and 9 amino acids ( Gly - 222 to Leu - 230 ) in the human thyrotropin receptor are involved in ligand binding ''. The Journal of Biological Chemistry. 266 ( 23 ) : 14926 -- 30. PMID 1651314. Murakami M, Mori M ( Aug 1990 ). `` Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves ' disease ''. Biochemical and Biophysical Research Communications. 171 ( 1 ) : 512 -- 8. PMID 1697467. doi : 10.1016 / 0006 - 291X ( 90 ) 91423 - P. Heldin NE, Gustavsson B, Westermark K, Westermark B ( Dec 1991 ). `` A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism ''. The Journal of Clinical Endocrinology and Metabolism. 73 ( 6 ) : 1374 -- 6. PMID 1955520. doi : 10.1210 / jcem - 73 - 6 - 1374. Libert F, Passage E, Lefort A, Vassart G, Mattei MG ( 1991 ). `` Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization ''. Cytogenetics and Cell Genetics. 54 ( 1 - 2 ) : 82 -- 3. PMID 2249482. doi : 10.1159 / 000132964. Frazier AL, Robbins LS, Stork PJ, Sprengel R, Segaloff DL, Cone RD ( Aug 1990 ). `` Isolation of TSH and LH / CG receptor cDNAs from human thyroid : regulation by tissue specific splicing ''. Molecular Endocrinology. 4 ( 8 ) : 1264 -- 76. PMID 2293030. doi : 10.1210 / mend - 4 - 8 - 1264. Misrahi M, Loosfelt H, Atger M, Sar S, Guiochon - Mantel A, Milgrom E ( Jan 1990 ). `` Cloning, sequencing and expression of human TSH receptor ''. Biochemical and Biophysical Research Communications. 166 ( 1 ) : 394 -- 403. PMID 2302212. doi : 10.1016 / 0006 - 291X ( 90 ) 91958 - U. Nagayama Y, Kaufman KD, Seto P, Rapoport B ( Dec 1989 ). `` Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor ''. Biochemical and Biophysical Research Communications. 165 ( 3 ) : 1184 -- 90. PMID 2558651. doi : 10.1016 / 0006 - 291X ( 89 ) 92727 - 7. Libert F, Lefort A, Gerard C, Parmentier M, Perret J, Ludgate M, Dumont JE, Vassart G ( Dec 1989 ). `` Cloning, sequencing and expression of the human thyrotropin ( TSH ) receptor : evidence for binding of autoantibodies ''. Biochemical and Biophysical Research Communications. 165 ( 3 ) : 1250 -- 5. PMID 2610690. doi : 10.1016 / 0006 - 291X ( 89 ) 92736 - 8. Cuddihy RM, Bryant WP, Bahn RS ( Aug 1995 ). `` Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor ''. Thyroid. 5 ( 4 ) : 255 -- 7. PMID 7488864. doi : 10.1089 / thy. 1995.5. 255. Bahn RS, Dutton CM, Heufelder AE, Sarkar G ( Feb 1994 ). `` A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves ' ophthalmopathy ''. The Journal of Clinical Endocrinology and Metabolism. 78 ( 2 ) : 256 -- 60. PMID 7508946. doi : 10.1210 / jc. 78.2. 256. Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S ( Jan 1995 ). `` Brief report : resistance to thyrotropin caused by mutations in the thyrotropin - receptor gene ''. The New England Journal of Medicine. 332 ( 3 ) : 155 -- 60. PMID 7528344. doi : 10.1056 / NEJM199501193320305. External links `` Glycoprotein Hormone Receptors : TSH ''. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Thyrotropin Receptors at the US National Library of Medicine Medical Subject Headings ( MeSH ) GRIS : Glycoprotein - hormone Receptor Information System Cell surface receptor : G protein -- coupled receptors Class A : Rhodopsin - like Neurotransmitter Adrenergic α1 ( A D ) α2 ( A C ) β1 β2 β3 Purinergic Adenosine ( A1 A2A A2B A3 ) P2Y ( 1 5 6 8 9 10 11 12 13 14 ) Serotonin ( all but 5 - HT3 ) 5 - HT1 ( A F ) 5 - HT2 ( A C ) 5 - HT ( 4 5A 6 7 ) Other Acetylcholine ( M1 M2 M3 M4 M5 ) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin ( 1A 1B 1C ) TAAR ( 1 5 6 8 9 ) Metabolites and signaling molecules Eicosanoid CysLT ( 1 2 ) LTB4 FPRL1 OXE Prostaglandin DP ( 1 2 ), EP ( 1 4 ), FP Prostacyclin Thromboxane Other Bile acid Cannabinoid ( CB1 CB2, GPR ( 18 55 119 ) ) EBI2 Estrogen Free fatty acid ( 1 4 ) Lactate Lysophosphatidic acid ( 1 5 6 ) Lysophospholipid ( 1 5 6 7 8 ) Niacin ( 1 2 ) Oxoglutarate PAF Sphingosine - 1 - phosphate ( 1 5 ) Succinate Peptide Neuropeptide B / W ( 1 2 ) FF ( 1 2 ) Y ( 1 5 ) Neuromedin ( B U ( 1 2 ) ) Neurotensin ( 1 2 ) Other Anaphylatoxin ( C3a C5a ) Angiotensin ( 1 2 ) Apelin Bombesin BRS3 GRPR NMBR ) Bradykinin ( B1 B2 ) Chemokine Cholecystokinin ( A B) Endothelin Formyl peptide ( 1 3 ) FSH Galanin ( 1 3 ) Gonadotropin - releasing hormone ( 1 2 ) Ghrelin Kisspeptin Luteinizing hormone / choriogonadotropin MAS ( 1 1L X1 X2 X3 X4 ) Melanocortin ( 1 5 ) MCHR ( 1 2 ) Motilin Opioid ( Delta Kappa Mu Nociceptin & Zeta, but not Sigma ) Orexin ( 1 2 ) Oxytocin Prokineticin ( 1 2 ) Prolactin - releasing peptide Relaxin ( 1 4 ) Somatostatin ( 1 5 ) Tachykinin ( 1 3 ) Thyrotropin Thyrotropin - releasing hormone Urotensin - II Vasopressin ( 1A 1B 2 ) Miscellaneous Orphan GPR ( 1 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183 ) Other Adrenomedullin Olfactory Opsin ( 3 5 1LW 1MW 1SW RGR RRH ) Protease - activated ( 1 4 ) SREB ( 1 3 ) Class B : Secretin - like Adhesion ADGRG ( 1 5 6 7 ) Orphan GPR ( 56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157 ) Other Brain - specific angiogenesis inhibitor ( 1 3 ) Cadherin ( 1 3 ) Calcitonin CALCRL CD97 Corticotropin - releasing hormone ( 1 2 ) EMR ( 1 3 ) Glucagon ( GR GIPR GLP1R GLP2R ) Growth - hormone - releasing hormone PACAPR1 GPR Latrophilin ( 1 ELTD1 ) Methuselah - like proteins Parathyroid hormone ( 1 2 ) Secretin Vasoactive intestinal peptide ( 1 2 ) Class C : Metabotropic glutamate / pheromone Taste TAS1R ( 1 3 ) TAS2R ( 1 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor ) Other Calcium - sensing receptor GABAB ( 1 2 ) Glutamate receptor ( Metabotropic glutamate ( 1 5 6 7 8 ) ) GPRC6A GPR ( 156 158 179 ) RAIG ( 1 4 ) Class F : Frizzled / Smoothened Frizzled Frizzled ( 1 5 6 7 8 9 10 ) Smoothened Smoothened Neuropeptide receptors G protein - coupled receptor Hormone receptors Hypothalamic CRH FSH LHRH TRH Somatostatin Pituitary Vasopressin 1A 1B Oxytocin LHCG TSH Other Atrial natriuretic factor NPR3 Calcitonin Cholecystokinin VIP Opioid receptors Delta Kappa Mu Nociceptin Other neuropeptide receptors Angiotensin Bradykinin B1 B2 Tachykinin TACR1 Calcitonin gene - related peptide Galanin GPCR neuropeptide B / W FF Y Neurotensin Type I cytokine receptor GH Prolactin Enzyme - linked receptor Atrial natriuretic factor NPR1 NPR2 Other Sigma Signaling peptide / protein receptor modulators Adiponectin AdipoR Agonists : Peptide : Adiponectin ADP - 355 ADP - 399 ; Non-peptide : AdipoRon ( -- ) - Arctigenin Arctiin Gramine Matairesinol Antagonists : Peptide : ADP - 400 AdipoR Agonists : Peptide : Adiponectin ADP - 355 ADP - 399 ; Non-peptide : AdipoRon Deoxyschizandrin Parthenolide Syringing Taxifoliol Antagonists : Peptide : ADP - 400 Angiotensin See here instead. Bradykinin Agonists : Bradykinin Kallidin Antagonists : FR - 173657 Icatibant LF22 - 0542 CGRP Agonists : Amylin CGRP Pramlintide Antagonists : Atogepant BI 44370 TA CGRP ( 8 - 37 ) MK - 3207 Olcegepant Rimegepant SB - 268262 Telcagepant Ubrogepant Antibodies : Erenumab Cholecystokinin CCK Agonists : Cholecystokinin Antagonists : Amiglumide Asperlicin Devazepide Dexloxiglumide Lintitript Lorglumide Loxiglumide Pranazepide Proglumide Tarazepide Tomoglumide CCK Agonists : Cholecystokinin CCK - 4 Gastrin Pentagastrin ( CCK - 5 ) Antagonists : Ceclazepide CI - 988 ( PD - 134308 ) Itriglumide L - 365,360 Netazepide Proglumide Spiroglumide Unsorted Antagonists : Nastorazepide CRH CRF Agonists : Cortagine Corticorelin Corticotropin releasing hormone Sauvagine Stressin I Urocortin Antagonists : Antalarmin Astressin - B CP - 154,526 Emicerfont Hypericin LWH - 234 NBI - 27914 Pexacerfont R - 121919 TS - 041 Verucerfont CRF Agonists : Corticorelin Corticotropin releasing hormone Sauvagine Urocortin Antagonists : Astressin - B Cytokine See here instead. Endothelin Agonists : Endothelin 1 Endothelin 2 Endothelin 3 IRL - 1620 Antagonists : A-192621 ACT - 132577 Ambrisentan Aprocitentan Atrasentan Avosentan Bosentan BQ - 123 BQ - 788 Clazosentan Darusentan Edonentan Enrasentan Fandosentan Feloprentan Macitentan Nebentan Sitaxentan Sparsentan Tezosentan Zibotentan Galanin GAL Agonists : Galanin Galanin ( 1 - 15 ) Galanin - like peptide Galmic Galnon NAX 810 - 2 Antagonists : C7 Dithiepine - 1, 1, 4, 4 - tetroxide Galantide ( M15 ) M32 M35 M40 SCH - 202596 GAL Agonists : Galanin Galanin ( 1 - 15 ) Galanin ( 2 - 11 ) Galanin - like peptide Galmic Galnon J18 NAX 810 - 2 Antagonists : C7 Galantide ( M15 ) M32 M35 M40 M871 GAL Agonists : Galanin Galanin ( 1 - 15 ) Galmic Galnon Antagonists : C7 Galantide ( M15 ) GalR3ant HT - 2157 M32 M35 M40 SNAP - 37889 SNAP - 398299 Ghrelin / GHS See here instead. GH See here instead. GHRH See here instead. GLP GLP - 1 Agonists : Albiglutide Beinaglutide Dulaglutide Efpeglenatide Exenatide GLP - 1 Langlenatide Liraglutide Lixisenatide Oxyntomodulin Semaglutide Taspoglutide GLP - 2 Agonists : Elsiglutide Glepaglutide GLP - 2 Teduglutide Others Propeptides : Preproglucagon Proglucagon Glucagon Agonists : Dasiglucagon Glucagon Oxyntomodulin Antagonists : Adomeglivant L - 168,049 LGD - 6972 Propeptides : Preproglucagon Proglucagon GnRH Agonists : Peptide : Avorelin Buserelin ( buserelin acetate ) Deslorelin Fertirelin ( fertirelin acetate ) Gonadorelin GnRH ( LHRH, gonadorelin ) Goserelin ( goserelin acetate ) Histrelin Leuprorelin ( leuprolide acetate ) Lutrelin Nafarelin Peforelin Triptorelin Zoptarelin doxorubicin Antagonists : Peptide : Abarelix Acyline Cetrorelix Degarelix Detirelix Ganirelix Iturelix Ozarelix Prazarelix Ramorelix Teverelix ( antarelix ) ; Non-peptide : ASP - 1707 Elagolix KLH - 2109 ( OBE - 2109 ) Relugolix Sufugolix Gonadotropin LH / CG Agonists : Choriogonadotropin alfa Human chorionic gonadotropin Luteinizing hormone Lutropin alfa Menotropin ( human menopausal gonadotropin ) FSH Agonists : Corifollitropin alfa Follicle - stimulating hormone Follitropin alfa Follitropin beta Follitropin epsilon Menotropin ( human menopausal gonadotropin ) Urofollitropin Varfollitropin alfa NAMs : ADX - 61623 Growth factor See here instead. Insulin Agonists : Chaetochromin ( 4548 - G05 ) Insulin - like growth factor 1 Insulin - like growth factor 2 Insulin Insulin aspart Insulin degludec Insulin detemir Insulin glargine Insulin glulisine Insulin lispro Mecasermin Mecasermin rinfabate Antagonists : BMS - 754807 S661 S961 Kinase inhibitors : Linsitinib Antibodies : Xentuzumab ( against IGF - 1 and IGF - 2 ) Kisspeptin Agonists : Kisspeptin Kisspeptin - 10 Antagonists : Kisspeptin - 234 Leptin Agonists : Leptin Metreleptin MCH MCH Agonists : Melanin concentrating hormone Antagonists : ATC - 0065 ATC - 0175 GW - 803430 NGD - 4715 SNAP - 7941 SNAP - 94847 MCH Agonists : Melanin concentrating hormone Melanocortin See here instead. Neuropeptide FF Agonists : Neuropeptide AF Neuropeptide FF Neuropeptide SF ( RFRP - 1 ) Neuropeptide VF ( RFRP - 3 ) Antagonists : BIBP - 3226 RF9 Neuropeptide S Agonists : Neuropeptide S Antagonists : ML - 154 SHA - 68 Neuropeptide Y Y Agonists : Neuropeptide Y Peptide YY Antagonists : BIBO - 3304 BIBP - 3226 BVD - 10 GR - 231118 PD - 160170 Y Agonists : 2 - Thiouridine 5 ' - triphosphate Neuropeptide Y Neuropeptide Y ( 13 - 36 ) Peptide YY Peptide YY ( 3 - 36 ) Antagonists : BIIE - 0246 JNJ - 5207787 SF - 11 Y Agonists : GR - 231118 Neuropeptide Y Pancreatic polypeptide Peptide YY Antagonists : UR - AK49 Y Agonists : BWX - 46 Neuropeptide Y Peptide YY Antagonists : CGP - 71683 FMS - 586 L - 152,804 Lu AA - 33810 MK - 0557 NTNCB Velneperit ( S - 2367 ) Neurotensin NTS Agonists : Neurotensin Neuromedin N Antagonists : Meclinertant SR - 142948 NTS Agonists : Neurotensin Antagonists : Levocabastine SR - 142948 Opioid See here instead. Orexin OX Agonists : Orexin ( A, B) Antagonists : ACT - 335827 ACT - 462206 Almorexant Filorexant Lemborexant SB - 334867 SB - 408124 SB - 649868 Suvorexant TCS - 1102 OX Agonists : Orexin ( A, B) SB - 668875 Antagonists : ACT - 335827 ACT - 462206 Almorexant EMPA Filorexant JNJ - 10397049 Lemborexant MK - 1064 SB - 649868 Seltorexant Suvorexant TCS - 1102 TCS - OX2 - 29 Oxytocin See here instead. Prolactin Agonists : Growth hormone Human placental lactogen Placental growth hormone ( growth hormone variant ) Prolactin S179D - hPRL Somatotropin Antagonists : Δ1 -- 9 - G129R - hPRL Δ1 -- 14 - G129R - hPRL G120K - hGH G129R - hPRL Prolactin modulators : Prolactin inhibitors : D receptor agonists ( e.g., bromocriptine, cabergoline ) ; Prolactin releasers : D receptor antagonists ( e.g., domperidone, metoclopramide, risperidone ) Estrogens ( e.g., estradiol ) Progestogens ( e.g., progesterone ) PTH Agonists : Abaloparatide Parathyroid hormone Parathyroid hormone - related protein ( PTHrP ) Semparatide Teriparatide Relaxin Agonists : Insulin - like factor 3 Relaxin ( 1, 2, 3 ) Serelaxin Somatostatin See here instead. Tachykinin See here instead. TRH Agonists : Azetirelin Fertirelin Montirelin Orotirelin Posatirelin Protirelin Rovatirelin Taltirelin TRH ( TRF ) TSH Agonists : Thyrotropin alfa TSH ( thyrotropin ) Vasopressin See here instead. VIP / PACAP VIPR Agonists : Peptide : Bay 55 - 9837 LBT - 3393 PACAP VIP VIPR Agonists : Peptide : LBT - 3627 PACAP VIP PAC Agonists : PACAP PACAP ( 1 - 27 ) PACAP ( 1 - 38 ) Antagonists : PACAP ( 6 - 38 ) Unsorted PHI PHM PHV Others Endogenous : Adrenomedullin Apelin Asprosin Bombesin Calcitonin Carnosine CART CLIP DSIP Enteroglucagon Formyl peptide GALP GIP GRP Integrin ligands ( collagens, fibrinogen, fibronectin, laminins, ICAM - 1, ICAM - 2, osteopontin, VCAM - 1, vitronectin ) Kininogens Motilin Natriuretic peptides ( ANP, BNP, CNP, urodilatin ) Nesfatin - 1 Neuromedin B Neuromedin N Neuromedin S Neuromedin U Obestatin Osteocalcin Resistin Secretin Thymopoietin Thymosins Thymulin Urotensin - II VGF Exogenous : Lifitegrast ( LFA - 1 antagonist ) See also Receptor / signaling modulators Retrieved from `` https://en.wikipedia.org/w/index.php?title=Thyrotropin_receptor&oldid=727571322 '' Categories : Genes on human chromosome 14 G protein coupled receptors Thyroid Talk Contents About Wikipedia Deutsch Français Português Русский Српски / srpski Srpskohrvatski / српскохрватски Svenska Українська 中文 Edit links This page was last edited on 29 June 2016, at 21 : 08. 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Question: what results from the binding of tsh to its receptors
Answer: thyroxine (T4)