Heterochromia iridum - wikipedia Heterochromia iridum Not to be confused with Heterochromatin or Dichromatic ( disambiguation ). Heterochromia Domestic cat with complete heterochromia Specialty Ophthalmology Heterochromia is a difference in coloration, usually of the iris but also of hair or skin. Heterochromia is determined by the production, delivery, and concentration of melanin ( a pigment ). It may be inherited, or caused by genetic mosaicism, chimerism, disease, or injury. It occurs in humans and certain breeds of dogs and cats. Heterochromia of the eye ( heterochromia iridum or heterochromia iridis ) is of three kinds. In complete heterochromia, one iris is a different color from the other. In segmental heterochromia or sectoral heterochromia, part of one iris is a different color from its remainder and finally in central heterochromia there are spikes of different colors radiating from the pupil. Though multiple causes have been posited, the scientific consensus is that a lack of genetic diversity is the primary reason behind heterochromia. This is due to a mutation of the genes that determine melanin distribution at the 8 - HTP pathway, which usually only become corrupted due to chromosomal homogeneity. Eye color, specifically the color of the irises, is determined primarily by the concentration and distribution of melanin. The affected eye may be hyperpigmented ( hyperchromic ) or hypopigmented ( hypochromic ). In humans, an increase of melanin production in the eyes indicates hyperplasia of the iris tissues, whereas a lack of melanin indicates hypoplasia. The term is from ancient Greek : ἕτερος, héteros meaning different and χρώμα, chróma meaning color. Contents 1 Classification 1.1 Segmental or sectoral heterochromia 1.1. 1 Abnormal iris darker 1.1. 2 Abnormal iris lighter 1.2 Acquired heterochromia 1.2. 1 Abnormal iris darker 1.2. 2 Abnormal iris lighter 1.3 Central heterochromia 2 In other animals 3 Gallery 4 See also 5 References 6 External links Classification Congenital heterochromia : inherited in autosomal dominant fashion ( from men or women ) Heterochromia is classified primarily by onset : as either genetic or acquired. Although a distinction is frequently made between heterochromia that affects an eye completely or only partially ( segmental heterochromia ), it is often classified as either genetic ( due to mosaicism or congenital ) or acquired, with mention as to whether the affected iris or portion of the iris is darker or lighter. Most cases of heterochromia are hereditary, caused by certain diseases and syndromes. Sometimes one eye may change color following disease or injury. Segmental or sectoral heterochromia Segmental heterochromia In segmental heterochromia, sometimes referred to as sectoral heterochromia, areas of the same iris contains two completely different colors. Segmental heterochromia is rare in humans ; it is estimated that only about 1 % of the population have it. Abnormal iris darker Lisch nodules -- iris hamartomas seen in neurofibromatosis. Ocular melanosis -- a condition characterized by increased pigmentation of the uveal tract, episclera, and anterior chamber angle. Oculodermal melanocytosis ( nevus of Ota ) Pigment dispersion syndrome -- a condition characterized by loss of pigmentation from the posterior iris surface which is disseminated intraocularly and deposited on various intraocular structures, including the anterior surface of the iris. Sturge -- Weber syndrome -- a syndrome characterized by a port - wine stain nevus in the distribution of the trigeminal nerve, ipsilateral leptomeningeal angiomas with intracranial calcification and neurologic signs, and angioma of the choroid, often with secondary glaucoma. Abnormal iris lighter Individual with Waardenburg Syndrome Type II exhibiting complete heterochromia iridum Simple heterochromia -- a rare condition characterized by the absence of other ocular or systemic problems. The lighter eye is typically regarded as the affected eye as it usually shows iris hypoplasia. It may affect an iris completely or only partially. Congenital Horner 's syndrome -- sometimes inherited, although usually acquired Waardenburg syndrome -- a syndrome in which heterochromia is expressed as a bilateral iris hypochromia in some cases. A Japanese review of 11 children with albinism found that the condition was present. All had sectoral / partial heterochromia. Piebaldism -- similar to Waardenburg 's syndrome, a rare disorder of melanocyte development characterized by a white forelock and multiple symmetrical hypopigmented or depigmented macules. Hirschsprung 's disease -- a bowel disorder associated with heterochromia in the form of a sector hypochromia. The affected sectors have been shown to have reduced numbers of melanocytes and decreased stromal pigmentation. Incontinentia pigmenti Parry -- Romberg syndrome Acquired heterochromia An Alaskan Husky sled dog with heterochromia Acquired heterochromia is usually due to injury, inflammation, the use of certain eyedrops that damages the iris, or tumors. Abnormal iris darker Deposition of material Siderosis -- iron deposition within ocular tissues due to a penetrating injury and a retained iron - containing, intraocular foreign body. Hemosiderosis -- long standing hyphema ( blood in the anterior chamber ) following blunt trauma to the eye may lead to iron deposition from blood products Certain eyedrops -- prostaglandin analogues ( latanoprost, isopropyl unoprostone, travoprost, and bimatoprost ) are used topically to lower intraocular pressure in glaucoma patients. A concentric heterochromia has developed in some patients applying these drugs. The stroma around the iris sphincter muscle becomes darker than the peripheral stroma. A stimulation of melanin synthesis within iris melanocytes has been postulated. Neoplasm -- Nevi and melanomatous tumors. Iridocorneal endothelium syndrome Iris ectropion syndrome Abnormal iris lighter Fuchs heterochromic iridocyclitis -- a condition characterized by a low grade, asymptomatic uveitis in which the iris in the affected eye becomes hypochromic and has a washed - out, somewhat moth eaten appearance. The heterochromia can be very subtle, especially in patients with lighter colored irides. It is often most easily seen in daylight. The prevalence of heterochromia associated with Fuchs has been estimated in various studies with results suggesting that there is more difficulty recognizing iris color changes in dark - eyed individuals. Acquired Horner 's syndrome -- usually acquired, as in neuroblastoma, although sometimes inherited. Neoplasm -- Melanomas can also be very lightly pigmented, and a lighter colored iris may be a rare manifestation of metastatic disease to the eye. Parry -- Romberg syndrome -- due to tissue loss. Heterochromia has also been observed in those with Duane syndrome. Chronic iritis Juvenile xanthogranuloma Leukemia and lymphoma Central heterochromia Example of central heterochromia showing a gold to blue iris Central heterochromia is an eye condition where there are two colors in the same iris ; the central ( pupillary ) zone of the iris is a different color than the mid-peripheral ( ciliary ) zone, with the true iris color being the outer color. ( requires reference ) Eye color is determined primarily by the concentration and distribution of melanin within the iris tissues. Although the processes determining eye color are not fully understood, it is known that inherited eye color is determined by multiple genes. Environmental or acquired factors can alter these inherited traits. The human iris can be seen in a number of various colors. There are three true colors in human eyes that determine the outward appearance : brown, yellow, and grey. The amount of each color an individual has determines the appearance of the eye color. Eyes displaying central heterochromia are often referred to as `` cat eyes '' because of their multi-colored iris. Central heterochromia appears to be prevalent in irises containing low amounts of melanin. A famous case of a person with central heterochromia was Baroness Rózsika Edle von Wertheimstein, whose daughter wrote : `` She was a very beautiful woman... She had dark, dark brown eyes, but each eye had a purple ring to it, about a quarter of an inch of purple around these dark brown eyes. '' In other animals See also : Odd - eyed cat Although infrequently seen in humans, complete heterochromia is more frequently observed in other species, where it almost always involves one blue eye. The blue eye occurs within a white spot, where melanin is absent from the skin and hair ( see Leucism ). These species include the cat, particularly breeds such as Turkish Van, Turkish Angora, Khao Manee and ( rarely ) Japanese Bobtail. These so - called odd - eyed cats are white, or mostly white, with one normal eye ( copper, orange, yellow, green ), and one blue eye. Among dogs, complete heterochromia is seen often in the Siberian Husky and few other breeds, usually Australian Shepherd and Catahoula Leopard Dog and rarely in Shih Tzu. Horses with complete heterochromia have one brown and one white, gray, or blue eye -- complete heterochromia is more common in horses with pinto coloring. Complete heterochromia occurs also in cattle and even water buffalo. It can also be seen in ferrets with Waardenburg syndrome, although it can be very hard to tell at times as the eye color is often a midnight blue. Sectoral heterochromia, usually sectoral hypochromia, is often seen in dogs, specifically in breeds with merle coats. These breeds include the Australian Shepherd, Border Collie, Collie, Shetland Sheepdog, Welsh Corgi, Pyrenean Shepherd, Mudi, Beauceron, Catahoula Cur, Dunker, Great Dane, Dachshund and Chihuahua. It also occurs in certain breeds that do not carry the merle trait, such as the Siberian Husky and rarely, Shih Tzu. There are example of cat breeds that have the condition such as Van cat. Gallery Actress Alice Eve has complete heterochromia : her left eye is blue and right eye is green. Actor Dominic Sherwood has sectoral heterochromia. Heterochromia in a child. Complete heterochromia in a teenager who also has anisocoria. Example of central heterochromia showing an orange to blue iris. Example of central heterochromia in green eye with speckled brown pigment. A young adult exhibiting sectoral heterochromia in the form of an orange segment in her right, blue eye. The individual 's mother exhibited a similar orange segment in her left eye, although her iris color was green. Norwegian forest cat with heterochromia. One blue, and one green. The blue one has sectoral heterochromia, as there is a bit of green in the top of the iris. A cat with complete heterochromia. This cat 's yellow eye has what looks like central heterochromia, as the outside of the eye is yellow, and the iris is green. Complete heterochromia in a Siberian Husky : one eye blue, one eye brown. Sectoral hypochromia in a blue merle Border Collie. See also Brushfield spots Coloboma Erythrism Leucism List of systemic diseases with ocular manifestations Piebaldism List of people with heterochromia References Jump up ^ PramodKumar. Focal Scalp Hair Heterochromia in an infant. Sultan Qaboos University Medical Journal Vol17, ( 1 ) pages 116 - 118. February 2017. PMC 5380409. doi : 10.18295 / squmj. 2016.17. 01.022 Jump up ^ Imesch PD, Wallow IH, Albert DM ( February 1997 ). `` The color of the human eye : a review of morphologic correlates and of some conditions that affect iridial pigmentation throughout life ''. Surv Ophthalmol. 41 ( Suppl 2 ) : S117 -- 23. doi : 10.1016 / S0039 - 6257 ( 97 ) 80018 - 5. PMID 9154287. ^ Jump up to : Loewenstein, John ; Scott Lee ( 2004 ). Ophthalmology : Just the Facts. New York : McGraw - Hill. ISBN 0 - 07 - 140332 - 9. ^ Jump up to : Wielgus AR, Sarna T ( December 2005 ). `` Melanin in human irides of different color and age of donors ''. Pigment Cell Res. 18 ( 6 ) : 454 -- 64. doi : 10.1111 / j. 1600 - 0749.2005. 00268. x. PMID 16280011. Jump up ^ Prota G, Hu DN, Vincensi MR, McCormick SA, Napolitano A ( September 1998 ). `` Characterization of melanins in human irides and cultured uveal melanocytes from eyes of different colors ''. Exp Eye Res. 67 ( 3 ) : 293 -- 9. doi : 10.1006 / exer. 1998.0518. PMID 9778410. Jump up ^ `` heterochromia iridis - definition of heterochromia iridis in the Medical dictionary - by the Free Online Medical Dictionary, Thesaurus and Encyclopedia ''. Medical-dictionary.thefreedictionary.com. Retrieved 2014 - 04 - 27. Jump up ^ Swann P. `` Heterochromia. '' Archived 2006 - 01 - 08 at the Wayback Machine. Optometry Today. January 29, 1999. Retrieved November 1, 2006. Jump up ^ `` Heterochromia : MedlinePlus Medical Encyclopedia ''. Nlm.nih.gov. Retrieved 2014 - 04 - 27. Jump up ^ https://rarediseases.info.nih.gov/diseases/8590/heterochromia-iridis Jump up ^ van Emelen C, Goethals M, Dralands L, Casteels I ( Jan -- Feb 2000 ). `` Treatment of glaucoma in children with Sturge - Weber syndrome ''. J Pediatr Ophthalmol Strabismus. 37 ( 1 ) : 29 -- 34. PMID 10714693. Jump up ^ `` Sturge - Weber syndrome : Definition and Much More from Answers.com ''. Answers.com < !. Retrieved 2009 - 11 - 19. ^ Jump up to : Wallis DH, Granet DB, Levi L ( June 2003 ). `` When the darker eye has the smaller pupil ''. J AAPOS. 7 ( 3 ) : 215 -- 6. doi : 10.1016 / S1091 - 8531 ( 02 ) 42020 - 4. PMID 12825064. Jump up ^ Ohno N, Kiyosawa M, Mori H, Wang WF, Takase H, Mochizuki M ( Jan -- Feb 2003 ). `` Clinical findings in Japanese patients with Waardenburg syndrome type 2 ''. Jpn J Ophthalmol. 47 ( 1 ) : 77 -- 84. doi : 10.1016 / S0021 - 5155 ( 02 ) 00629 - 9. PMID 12586183. Jump up ^ Brazel SM, Sullivan TJ, Thorner PS, Clarke MP, Hunter WS, Morin JD ( February 1992 ). `` Iris sector heterochromia as a marker for neural crest disease ''. Arch Ophthalmol. 110 ( 2 ) : 233 -- 5. doi : 10.1001 / archopht. 1992.01080140089033. PMID 1736874. Jump up ^ Liu CSC ( August 1999 ). `` A case of acquired iris depigmentation as a possible complication of levobunolol eye drops ''. British Journal of Ophthalmology. 83 ( 12 ). doi : 10.1136 / bjo. 83.12. 1403c. Jump up ^ Yang P, Fang W, Jin H, Li B, Chen X, Kijlstra A ( March 2006 ). `` Clinical features of Chinese patients with Fuchs ' syndrome ''. Ophthalmology. 113 ( 3 ) : 473 -- 80. doi : 10.1016 / j. ophtha. 2005.10. 028. PMID 16458965. Jump up ^ Arellanes - Garcia L, del Carmen Preciado - Delgadillo M, Recillas - Gispert C ( June 2002 ). `` Fuchs ' heterochromic iridocyclitis : clinical manifestations in dark - eyed Mexican patients ''. Ocul Immunol Inflamm. 10 ( 2 ) : 125 -- 31. doi : 10.1076 / ocii. 10.2. 125.13976. PMID 12778348. ^ Jump up to : Tabbut BR, Tessler HH, Williams D ( December 1988 ). `` Fuchs ' heterochromic iridocyclitis in blacks ''. Arch Ophthalmol. 106 ( 12 ) : 1688 -- 90. doi : 10.1001 / archopht. 1988.01060140860027. PMID 3196209. Jump up ^ Bloch - Michel E ( 1983 ). `` Fuchs heterochromic cyclitis : current concepts ''. J Fr Ophtalmol. ( in French ). 6 ( 10 ) : 853 -- 8. PMID 6368659. Jump up ^ Mehta K, Haller JO, Legasto AC ( 2003 ). `` Imaging neuroblastoma in children ''. Crit Rev Comput Tomogr. 44 ( 1 ) : 47 -- 61. doi : 10.1080 / 10408370390808469. PMID 12627783. Jump up ^ Genetic and Rare Diseases Information Center ( GARD ). `` Heterochromia iridis ''. Jump up ^ Khan AO, Aldamesh M ( June 2006 ). `` Bilateral Duane syndrome and bilateral aniridia ''. J AAPOS. 10 ( 3 ) : 273 -- 4. doi : 10.1016 / j. jaapos. 2006.02. 002. PMID 16814183. Jump up ^ Shauly Y, Weissman A, Meyer E ( May -- Jun 1993 ). `` Ocular and systemic characteristics of Duane syndrome ''. J Pediatr Ophthalmol Strabismus. 30 ( 3 ) : 178 -- 83. PMID 8350229. Jump up ^ Seddon JM, Sahagian CR, Glynn RJ, Sperduto RD, Gragoudas ES ( August 1990 ). `` Evaluation of an iris color classification system ''. Invest Ophthalmol Vis Sci. 31 ( 8 ) : 1592 -- 8. PMID 2201662. Jump up ^ `` Key Ocular Signs for Screening ''. Milesresearch.com. Retrieved 2009 - 11 - 19. Jump up ^ Dame Miriam Rothschild, by Naomi Gryn, Jewish Quarterly, Spring 2004, page 54 Jump up ^ Misk NA, Semieka MA, Fathy A ( 1998 ). `` Heterochromia iridis in water buffaloes ( Bubalus bubalis ) ''. Vet Ophthalmol. 1 ( 4 ) : 195 -- 201. doi : 10.1046 / j. 1463 - 5224.1998. 00036. x. PMID 11397231. External links Classification V T D ICD - 10 : Q13. 2, H20. 8, L67. 1 ICD - 9 - CM : 364.53 OMIM : 142500 DiseasesDB : 31289 External resources MedlinePlus : 003319 Wikimedia Commons has media related to Heterochromia. Photograph of Radial Reddish Sunburst Pattern in Right Eye of Bluish Hazel Eyed Woman Diseases of the human eye ( H00 -- H59 360 -- 379 ) Adnexa Eyelid Inflammation Stye Chalazion Blepharitis Entropion Ectropion Lagophthalmos Blepharochalasis Ptosis Blepharophimosis Xanthelasma Eyelash Trichiasis Madarosis Lacrimal apparatus Dacryoadenitis Epiphora Dacryocystitis Xerophthalmia Orbit Exophthalmos Enophthalmos Orbital cellulitis Orbital lymphoma Periorbital cellulitis Conjunctiva Conjunctivitis allergic Pterygium Pinguecula Subconjunctival hemorrhage Globe Fibrous tunic Sclera Scleritis Episcleritis Cornea Keratitis herpetic acanthamoebic fungal Corneal ulcer Photokeratitis Thygeson 's superficial punctate keratopathy Corneal dystrophy Fuchs ' Meesmann Corneal ectasia Keratoconus Pellucid marginal degeneration Keratoglobus Terrien 's marginal degeneration Post-LASIK ectasia Keratoconjunctivitis sicca Corneal neovascularization Kayser -- Fleischer ring Haab 's striae Arcus senilis Band keratopathy Vascular tunic Iris Ciliary body Uveitis Intermediate uveitis Hyphema Rubeosis iridis Persistent pupillary membrane Iridodialysis Synechia Choroid Choroideremia Choroiditis Chorioretinitis Lens Cataract Congenital cataract Childhood cataract Aphakia Ectopia lentis Retina Retinitis Chorioretinitis Cytomegalovirus retinitis Retinal detachment Retinoschisis Ocular ischemic syndrome / Central retinal vein occlusion Central retinal artery occlusion Retinopathy diabetic hypertensive Purtscher 's of prematurity Bietti 's crystalline dystrophy Coats ' disease Macular degeneration Retinitis pigmentosa Retinal haemorrhage Central serous retinopathy Macular edema Epiretinal membrane ( Macular pucker ) Vitelliform macular dystrophy Leber 's congenital amaurosis Birdshot chorioretinopathy Other Glaucoma / Ocular hypertension / Primary juvenile glaucoma Floater Leber 's hereditary optic neuropathy Red eye Globe rupture Keratomycosis Phthisis bulbi Persistent fetal vasculature / Persistent hyperplastic primary vitreous Persistent tunica vasculosa lentis Familial exudative vitreoretinopathy Pathways Optic nerve Optic disc Optic neuritis optic papillitis Papilledema Foster Kennedy syndrome Optic atrophy Optic disc drusen Optic neuropathy Ischemic anterior ( AION ) posterior ( PION ) Kjer 's Leber 's hereditary Toxic and nutritional Strabismus Extraocular muscles Binocular vision Accommodation Paralytic strabismus Ophthalmoparesis Chronic progressive external ophthalmoplegia Kearns -- Sayre syndrome palsies Oculomotor ( III ) Fourth - nerve ( IV ) Sixth - nerve ( VI ) Other strabismus Esotropia / Exotropia Hypertropia Heterophoria Esophoria Exophoria Cyclotropia Brown 's syndrome Duane syndrome Other binocular Conjugate gaze palsy Convergence insufficiency Internuclear ophthalmoplegia One and a half syndrome Refraction Refractive error Hyperopia Myopia Astigmatism Anisometropia / Aniseikonia Presbyopia Vision disorders Blindness Amblyopia Leber 's congenital amaurosis Diplopia Scotoma Color blindness Achromatopsia Dichromacy Monochromacy Nyctalopia Oguchi disease Blindness / Vision loss / Visual impairment Anopsia Hemianopsia binasal bitemporal homonymous Quadrantanopia subjective Asthenopia Hemeralopia Photophobia Scintillating scotoma Pupil Anisocoria Argyll Robertson pupil Marcus Gunn pupil Adie syndrome Miosis Mydriasis Cycloplegia Parinaud 's syndrome Other Nystagmus Childhood blindness Infections Trachoma Onchocerciasis Pigmentation disorders / Dyschromia ( L80 -- L81, 709.0 ) Hypo - / leucism Loss of melanocytes Vitiligo Quadrichrome vitiligo Vitiligo ponctué Syndromic Alezzandrini syndrome Vogt -- Koyanagi -- Harada syndrome Melanocyte development Piebaldism Waardenburg syndrome Tietz syndrome Loss of melanin / amelanism Albinism Oculocutaneous albinism Ocular albinism Melanosome transfer Hermansky -- Pudlak syndrome Chédiak -- Higashi syndrome Griscelli syndrome Elejalde syndrome Griscelli syndrome type 2 Griscelli syndrome type 3 Other Cross syndrome ABCD syndrome Albinism -- deafness syndrome Idiopathic guttate hypomelanosis Phylloid hypomelanosis Progressive macular hypomelanosis Leukoderma w / o hypomelanosis Vasospastic macule Woronoff 's ring Nevus anemicus Ungrouped Nevus depigmentosus Postinflammatory hypopigmentation Pityriasis alba Vagabond 's leukomelanoderma Yemenite deaf - blind hypopigmentation syndrome Wende -- Bauckus syndrome Hyper - Melanin / Melanosis / Melanism Reticulated Dermatopathia pigmentosa reticularis Pigmentatio reticularis faciei et colli Reticulate acropigmentation of Kitamura Reticular pigmented anomaly of the flexures Naegeli -- Franceschetti -- Jadassohn syndrome Dyskeratosis congenita X-linked reticulate pigmentary disorder Galli -- Galli disease Revesz syndrome Diffuse / circumscribed Lentigo / Lentiginosis : Lentigo simplex Liver spot Centrofacial lentiginosis Generalized lentiginosis Inherited patterned lentiginosis in black persons Ink spot lentigo Lentigo maligna Mucosal lentigines Partial unilateral lentiginosis PUVA lentigines Melasma Erythema dyschromicum perstans Lichen planus pigmentosus Café au lait spot Poikiloderma ( Poikiloderma of Civatte Poikiloderma vasculare atrophicans ) Riehl melanosis Linear Incontinentia pigmenti Scratch dermatitis Shiitake mushroom dermatitis Other / ungrouped Acanthosis nigricans Freckle Familial progressive hyperpigmentation Pallister -- Killian syndrome Periorbital hyperpigmentation Photoleukomelanodermatitis of Kobori Postinflammatory hyperpigmentation Transient neonatal pustular melanosis Other pigments Iron Hemochromatosis Iron metallic discoloration Pigmented purpuric dermatosis Schamberg disease Majocchi 's disease Gougerot -- Blum syndrome Doucas and Kapetanakis pigmented purpura / Eczematid - like purpura of Doucas and Kapetanakis Lichen aureus Angioma serpiginosum Hemosiderin hyperpigmentation Other metals Argyria Chrysiasis Arsenic poisoning Lead poisoning Titanium metallic discoloration Other Carotenosis Tattoo Tar melanosis Dyschromia Dyschromatosis symmetrica hereditaria Dyschromatosis universalis hereditaria See also Skin color Skin whitening Tanning ( Sunless ) Medicine Outline History Specialties and subspecialties Surgery Cardiac surgery Cardiothoracic surgery Colorectal surgery Eye surgery General surgery Neurosurgery Oral and maxillofacial surgery Orthopedic surgery Hand surgery Otolaryngology ( ENT ) Pediatric surgery Plastic surgery Reproductive surgery Surgical oncology Thoracic surgery Transplant surgery Trauma surgery Urology Andrology Vascular surgery Internal medicine Allergy / Immunology Angiology Cardiology Endocrinology Gastroenterology Hepatology Geriatrics Hematology Hospital medicine Infectious disease Nephrology Oncology Pulmonology Rheumatology Obstetrics and gynaecology Gynaecology Gynecologic oncology Maternal -- fetal medicine Obstetrics Reproductive endocrinology and infertility Urogynecology Diagnostic Radiology Interventional radiology Nuclear medicine Pathology Anatomical pathology Clinical pathology Clinical chemistry Clinical immunology Cytopathology Medical microbiology Transfusion medicine Other specialties Addiction medicine Adolescent medicine Anesthesiology Dermatology Disaster medicine Diving medicine Emergency medicine Mass - gathering medicine Family medicine General practice Hospital medicine Intensive - care medicine Medical genetics Neurology Clinical neurophysiology Occupational medicine Ophthalmology Oral medicine Pain management Palliative care Pediatrics Neonatology Physical medicine and rehabilitation ( PM&R ) Preventive medicine Psychiatry Public health Radiation oncology Reproductive medicine Sexual medicine Sleep medicine Sports medicine Transplantation medicine Tropical medicine Travel medicine Venereology Medical education Medical school Bachelor of Medicine, Bachelor of Surgery Bachelor of Medical Sciences Master of Medicine Master of Surgery Doctor of Medicine Doctor of Osteopathic Medicine MD -- PhD Related topics Allied health Dentistry Podiatry Physiotherapy Nanomedicine Molecular oncology Personalized medicine Veterinary medicine Physician Chief physician History of medicine Book Retrieved from `` https://en.wikipedia.org/w/index.php?title=Heterochromia_iridum&oldid=839344315 '' Categories : Diseases of the eye and adnexa Disturbances of pigmentation Eye color Genodermatoses Medical signs Hidden categories : Webarchive template wayback links CS1 French - language sources ( fr ) Infobox medical condition ( new ) All articles with unsourced statements Articles with unsourced statements from April 2015 Articles with unsourced statements from January 2016 Articles with unsourced statements from October 2017 Pages using div col without cols and colwidth parameters Pages using Columns - list with deprecated parameters Talk Contents About Wikipedia Afrikaans Azərbaycanca Български Català Čeština Dansk Deutsch Eesti Ελληνικά Español Esperanto Euskara فارسی Français Galego 한국어 Հայերեն Hrvatski Italiano עברית Latviešu Lëtzebuergesch Magyar Bahasa Melayu Nederlands 日本 語 Norsk Polski Português Română Русский Simple English Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska Türkçe Українська Tiếng Việt 中文 32 more Edit links This page was last edited on 2 May 2018, at 20 : 37. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: what do you call a person with two different eye colors
Answer: Heterochromia of the eye