Prefrontal cortex - Wikipedia Prefrontal cortex `` Prefrontal '' redirects here. For the skull bone, see Prefrontal bone. For the reptile scale, see Prefrontal scale. Prefrontal Cortex Brodmann areas, 9, 10, 11, 12, 13, 14, 24, 25, 32, 44, 45, 46, and 47 are all in the prefrontal cortex Details Part of Frontal lobe Parts Superior frontal gyrus Middle frontal gyrus Inferior frontal gyrus Artery Anterior cerebral Middle cerebral Vein Superior sagittal sinus Identifiers Latin Cortex praefrontalis MeSH D017397 NeuroNames 2429 NeuroLex ID nlx_anat_090801 FMA 224850 Anatomical terms of neuroanatomy ( edit on Wikidata ) In mammalian brain anatomy, the prefrontal cortex ( PFC ) is the cerebral cortex which covers the front part of the frontal lobe. The PFC contains Brodmann areas 8, 9, 10, 11, 12, 13, 14, 24, 25, 32, 44, 45, 46, and 47. Many authors have indicated an integral link between a person 's will to live, personality, and the functions of the prefrontal cortex. This brain region has been implicated in planning complex cognitive behavior, personality expression, decision making, and moderating social behavior. The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals. The most typical psychological term for functions carried out by the prefrontal cortex area is executive function. Executive function relates to abilities to differentiate among conflicting thoughts, determine good and bad, better and best, same and different, future consequences of current activities, working toward a defined goal, prediction of outcomes, expectation based on actions, and social `` control '' ( the ability to suppress urges that, if not suppressed, could lead to socially unacceptable outcomes ). Frontal cortex supports concrete rule learning. More anterior regions along the rostro - caudal axis of frontal cortex support rule learning at higher levels of abstraction. Contents 1 Structure 1.1 Definition 1.2 Subdivisions 1.3 Interconnections 2 Function 2.1 Executive function 2.2 Attention and memory 3 Clinical significance 4 History 4.1 Etymology 5 Additional images 6 See also 7 References 8 External links Structure Definition This section needs to be updated. Please update this article to reflect recent events or newly available information. ( March 2017 ) There are three possible ways to define the prefrontal cortex : as the granular frontal cortex as the projection zone of the medial dorsal nucleus of the thalamus as that part of the frontal cortex whose electrical stimulation does not evoke movements The prefrontal cortex has been defined based on cytoarchitectonics by the presence of a cortical granular layer IV. It is not entirely clear who first used this criterion. Many of the early cytoarchitectonic researchers restricted the use of the term prefrontal to a much smaller region of cortex including the gyrus rectus and the gyrus rostralis ( Campbell, 1905 ; G.E. Smith, 1907 ; Brodmann, 1909 ; von Economo and Koskinas, 1925 ). In 1935, however, Jacobsen used the term prefrontal to distinguish granular prefrontal areas from agranular motor and premotor areas. In terms of Brodmann areas, the prefrontal cortex traditionally includes areas 8, 9, 10, 11, 12, 13, 14, 24, 25, 32, 44, 45, 46, and 47, however, not all of these areas are strictly granular -- 44 is dysgranular, caudal 11 and orbital 47 are agranular. The main problem with this definition is that it works well only in primates but not in nonprimates, as the latter lack a granular layer IV. To define the prefrontal cortex as the projection zone of the mediodorsal nucleus of the thalamus builds on the work of Rose and Woolsey, who showed that this nucleus projects to anterior and ventral parts of the brain in nonprimates, however, Rose and Woolsey termed this projection zone `` orbitofrontal. '' It seems to have been Akert, who, for the first time in 1964, explicitly suggested that this criterion could be used to define homologues of the prefrontal cortex in primates and nonprimates. This allowed the establishment of homologies despite the lack of a granular frontal cortex in nonprimates. The projection zone definition is still widely accepted today ( e.g. Fuster ), although its usefulness has been questioned. Modern tract tracing studies have shown that projections of the mediodorsal nucleus of the thalamus are not restricted to the granular frontal cortex in primates. As a result, it was suggested to define the prefrontal cortex as the region of cortex that has stronger reciprocal connections with the mediodorsal nucleus than with any other thalamic nucleus. Uylings et al. acknowledge, however, that even with the application of this criterion, it might be rather difficult to define the prefrontal cortex unequivocally. A third definition of the prefrontal cortex is the area of frontal cortex whose electrical stimulation does not lead to observable movements. For example, in 1890 David Ferrier used the term in this sense. One complication with this definition is that the electrically `` silent '' frontal cortex includes both granular and non-granular areas. Subdivisions `` Prelimbic cortex '' redirects here. For the more specific brain region, see Brodmann area 32. Medial and lateral view of the prefrontal cortex The table below shows different ways to subdivide parts of the prefrontal cortex based upon Brodmann areas. 8 lateral 9 46 12 44 45 47 medial 9 medial 10 24 25 32 11 13 14 caudal lateral medial orbitofrontal dorsolateral ventrolateral The medial prefrontal cortex ( mPFC ) is composed of granular cortical areas ( medial areas 9 and 10 ) and agranular regions ( areas 24, 25, and 32 ) which encompasses the anterior cingulate cortex ( area 24 ), infralimbic cortex ( area 25 ), and prelimbic cortex ( area 32 ). The orbitofrontal cortex is composed of granular cortical areas ( area 11 ) and mixed granular and agranular regions ( areas 13 and 14 ). The ventrolateral prefrontal cortex is composed of areas 12, 44, 45, and 47. The dorsolateral prefrontal cortex is composed of the lateral part of area 9 and all of area 46. The caudal prefrontal cortex is composed of area 8, including the frontal eye fields. Interconnections The prefrontal cortex is highly interconnected with much of the brain, including extensive connections with other cortical, subcortical and brain stem sites. The dorsal prefrontal cortex is especially interconnected with brain regions involved with attention, cognition and action, while the ventral prefrontal cortex interconnects with brain regions involved with emotion. The prefrontal cortex also receives inputs from the brainstem arousal systems, and its function is particularly dependent on its neurochemical environment. Thus, there is coordination between our state of arousal and our mental state. The interplay between the prefrontal cortex and socioemotional system of the brain is relevant for adolescent development, as proposed by the Dual Systems Model. The medial prefrontal cortex has been implicated in the generation of slow - wave sleep ( SWS ), and prefrontal atrophy has been linked to decreases in SWS. Prefrontal atrophy occurs naturally as individuals age, and it has been demonstrated that older adults experience impairments in memory consolidation as their medial prefrontal cortices degrade. In monkeys, significant atrophy has been found as a result of neuroleptic or antipsychotic psychiatric medication. In older adults, instead of being transferred and stored in the neocortex during SWS, memories start to remain in the hippocampus where they were encoded, as evidenced by increased hippocampal activation compared to younger adults during recall tasks, when subjects learned word associations, slept, and then were asked to recall the learned words. Function Executive function The original studies of Fuster and of Goldman - Rakic emphasized the fundamental ability of the prefrontal cortex to represent information not currently in the environment, and the central role of this function in creating the `` mental sketch pad ''. Goldman - Rakic spoke of how this representational knowledge was used to intelligently guide thought, action, and emotion, including the inhibition of inappropriate thoughts, distractions, actions, and feelings. In this way, working memory can be seen as fundamental to attention and behavioral inhibition. Fuster speaks of how this prefrontal ability allows the wedding of past to future, allowing both cross-temporal and cross-modal associations in the creation of goal - directed, perception - action cycles. This ability to represent underlies all other higher executive functions. Shimamura proposed Dynamic Filtering Theory to describe the role of the prefrontal cortex in executive functions. The prefrontal cortex is presumed to act as a high - level gating or filtering mechanism that enhances goal - directed activations and inhibits irrelevant activations. This filtering mechanism enables executive control at various levels of processing, including selecting, maintaining, updating, and rerouting activations. It has also been used to explain emotional regulation. Miller and Cohen proposed an Integrative Theory of Prefrontal Cortex Function, that arises from the original work of Goldman - Rakic and Fuster. The two theorize that `` cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represents goals and means to achieve them. They provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task ''. In essence, the two theorize that the prefrontal cortex guides the inputs and connections, which allows for cognitive control of our actions. The prefrontal cortex is of significant importance when top - down processing is needed. Top - down processing by definition is when behavior is guided by internal states or intentions. According to the two, `` The PFC is critical in situations when the mappings between sensory inputs, thoughts, and actions either are weakly established relative to other existing ones or are rapidly changing ''. An example of this can be portrayed in the Wisconsin Card Sorting Test ( WCST ). Subjects engaging in this task are instructed to sort cards according to the shape, color, or number of symbols appearing on them. The thought is that any given card can be associated with a number of actions and no single stimulus - response mapping will work. Human subjects with PFC damage are able to sort the card in the initial simple tasks, but unable to do so as the rules of classification change. Miller and Cohen conclude that the implications of their theory can explain how much of a role the PFC has in guiding control of cognitive actions. In the researchers ' own words, they claim that, `` depending on their target of influence, representations in the PFC can function variously as attentional templates, rules, or goals by providing top - down bias signals to other parts of the brain that guide the flow of activity along the pathways needed to perform a task ''. Experimental data indicate a role for the prefrontal cortex in mediating normal sleep physiology, dreaming and sleep - deprivation phenomena. When analyzing and thinking about attributes of other individuals, the medial prefrontal cortex is activated, however, it is not activated when contemplating the characteristics of inanimate objects. Studies using fMRI have shown that the medial prefrontal cortex ( mPFC ), specifically the anterior medial prefrontal cortex ( amPFC ), may modulate mimicry behavior. Neuroscientists are suggesting that social priming influences activity and processing in the amPFC, and that this area of the prefrontal cortex modulates mimicry responses and behavior. As of recent, researchers have used neuroimaging techniques to find that along with the basal ganglia, the prefrontal cortex is involved with learning exemplars, which is part of the exemplar theory, one of the three main ways our mind categorizes things. The exemplar theory states that we categorize judgements by comparing it to a similar past experience within our stored memories. A 2014 meta - analysis by Professor Nicole P. Yuan from the University of Arizona found that larger prefrontal cortex volume and greater PFC cortical thickness were associated with better executive performance. Attention and memory Lebedev et al. experiment that dissociated representation of spatial attention from representation of spatial memory in prefrontal cortex A widely accepted theory regarding the function of the brain 's prefrontal cortex is that it serves as a store of short - term memory. This idea was first formulated by Jacobsen, who reported in 1936 that damage to the primate prefrontal cortex caused short - term memory deficits. Karl Pribram and colleagues ( 1952 ) identified the part of the prefrontal cortex responsible for this deficit as area 46, also known as the dorsolateral prefrontal cortex ( dlPFC ). More recently, Goldman - Rakic and colleagues ( 1993 ) evoked short - term memory loss in localized regions of space by temporary inactivation of portions of the dlPFC. Once the concept of working memory ( see also Baddeley 's model of working memory ) was established in contemporary neuroscience by Baddeley ( 1986 ), these neuropsychological findings contributed to the theory that the prefrontal cortex implements working memory and, in some extreme formulations, only working memory. In the 1990s this theory developed a wide following, and it became the predominant theory of PF function, especially for nonhuman primates. The concept of working memory used by proponents of this theory focused mostly on the short - term maintenance of information, and rather less on the manipulation or monitoring of such information or on the use of that information for decisions. Consistent with the idea that the prefrontal cortex functions predominantly in maintenance memory, delay - period activity in the PF has often been interpreted as a memory trace. ( The phrase `` delay - period activity '' applies to neuronal activity that follows the transient presentation of an instruction cue and persists until a subsequent `` go '' or `` trigger '' signal. ) To explore alternative interpretations of delay - period activity in the prefrontal cortex, Lebedev et al. ( 2004 ) investigated the discharge rates of single prefrontal neurons as monkeys attended to a stimulus marking one location while remembering a different, unmarked location. Both locations served as potential targets of a saccadic eye movement. Although the task made intensive demands on short - term memory, the largest proportion of prefrontal neurons represented attended locations, not remembered ones. These findings showed that short - term memory functions can not account for all, or even most, delay - period activity in the part of the prefrontal cortex explored. The authors suggested that prefrontal activity during the delay - period contributes more to the process of attentional selection ( and selective attention ) than to memory storage. Clinical significance See also : Neurobiological effects of physical exercise § Structural growth In the last few decades, brain imaging systems have been used to determine brain region volumes and nerve linkages. Several studies have indicated that reduced volume and interconnections of the frontal lobes with other brain regions is observed in patients diagnosed with mental disorders and prescribed potent antipsychotics ; those subjected to repeated stressors ; suicides ; those incarcerated ; criminals ; sociopaths ; those affected by lead poisoning ; and daily male cannabis users ( only 13 people were tested ). It is believed that at least some of the human abilities to feel guilt or remorse, and to interpret reality, are dependent on a well - functioning prefrontal cortex. It is also widely believed that the size and number of connections in the prefrontal cortex relates directly to sentience, as the prefrontal cortex in humans occupies a far larger percentage of the brain than in any other animal. And it is theorized that, as the brain has tripled in size over five million years of human evolution, the prefrontal cortex has increased in size sixfold. A review on executive functions in healthy exercising individuals noted that the left and right halves of the prefrontal cortex, which is divided by the medial longitudinal fissure, appear to become more interconnected in response to consistent aerobic exercise. Two reviews of structural neuroimaging research indicate that marked improvements in prefrontal and hippocampal gray matter volume occur in healthy adults that engage in medium intensity exercise for several months. A functional neuroimaging review of meditation - based practices suggested that practicing mindfulness enhances prefrontal activation, which was noted to be correlated with increased well - being and reduced anxiety ; however, the review noted the need for cohort studies in future research to better establish this. History Perhaps the seminal case in prefrontal cortex function is that of Phineas Gage, whose left frontal lobe was destroyed when a large iron rod was driven through his head in an 1848 accident. The standard presentation ( e.g. ) is that, although Gage retained normal memory, speech and motor skills, his personality changed radically : He became irritable, quick - tempered, and impatient -- characteristics he did not previously display -- so that friends described him as `` no longer Gage '' ; and, whereas he had previously been a capable and efficient worker, afterward he was unable to complete tasks. However, careful analysis of primary evidence shows that descriptions of Gage 's psychological changes are usually exaggerated when held against the description given by Gage 's doctor, the most striking feature being that changes described years after Gage 's death are far more dramatic than anything reported while he was alive. Subsequent studies on patients with prefrontal injuries have shown that the patients verbalized what the most appropriate social responses would be under certain circumstances. Yet, when actually performing, they instead pursued behavior aimed at immediate gratification, despite knowing the longer - term results would be self - defeating. The interpretation of this data indicates that not only are skills of comparison and understanding of eventual outcomes harbored in the prefrontal cortex but the prefrontal cortex ( when functioning correctly ) controls the mental option to delay immediate gratification for a better or more rewarding longer - term gratification result. This ability to wait for a reward is one of the key pieces that define optimal executive function of the human brain. There is much current research devoted to understanding the role of the prefrontal cortex in neurological disorders. Many disorders, such as schizophrenia, bipolar disorder, and ADHD, have been related to dysfunction of the prefrontal cortex, and thus this area of the brain offers the potential for new treatments of these conditions. Clinical trials have begun on certain drugs that have been shown to improve prefrontal cortex function, including guanfacine, which acts through the alpha - 2A adrenergic receptor. A downstream target of this drug, the HCN channel, is one of the most recent areas of exploration in prefrontal cortex pharmacology. Etymology The term `` prefrontal '' as describing a part of the brain appears to have been introduced by Richard Owen in 1868. For him, the prefrontal area was restricted to the anterior-most part of the frontal lobe ( approximately corresponding to the frontal pole ). It has been hypothesized that his choice of the term was based on the prefrontal bone present in most amphibians and reptiles. Additional images Animation, prefrontal cortex of left cerebral hemisphere ( shown in red ) Front view Lateral view Medial view See also This article uses anatomical terminology ; for an overview, see Anatomical terminology. Lobotomy Interference theory Self - model theory of subjectivity Dorsomedial prefrontal cortex References ^ Jump up to : Elisabeth Murray, Steven Wise, Kim Graham ( 2016 ). `` Chapter 1 : The History of Memory Systems ''. 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A relative prefrontal increase was reflective of mindfulness, which related to decreased anxiety and improved well - being... Future research can begin to use cohorts of participants in mindfulness studies which are controlled for using the variable of spirituality to explicitly examine how functional and structural similarities and differences may arise. Jump up ^ Antonio Damasio, Descartes ' Error. Penguin Putman Pub., 1994 Jump up ^ Malcolm Macmillan, An Odd Kind of Fame : Stories of Phineas Gage ( MIT Press, 2000 ), pp. 116 - 119, 307 - 333, esp. pp. 11,333. Jump up ^ Macmillan, M. ( 2008 ). `` Phineas Gage -- Unravelling the myth ''. The Psychologist. British Psychological Society. 21 ( 9 ) : 828 -- 831. Jump up ^ Wang M, Ramos BP, Paspalas CD, et al. ( April 2007 ). `` Alpha2A - adrenoceptors strengthen working memory networks by inhibiting cAMP - HCN channel signaling in prefrontal cortex ''. Cell. 129 ( 2 ) : 397 -- 410. doi : 10.1016 / j. cell. 2007.03. 015. PMID 17448997. External links Wikimedia Commons has media related to Prefrontal cortex. Diagram ( ua.edu ) Diagram ( universe-review.ca ) Stained brain slice images which include the `` Prefrontal cortex '' at the BrainMaps project Anatomy of the cerebral cortex of the human brain Frontal lobe Superolateral Prefrontal Superior frontal gyrus 6 8 Middle frontal gyrus 9 10 46 Inferior frontal gyrus : 11 47 - Pars orbitalis Broca 's area 44 - Pars opercularis 45 - Pars triangularis Superior frontal sulcus Inferior frontal sulcus Precentral Precentral gyrus Precentral sulcus Medial / inferior Prefrontal Superior frontal gyrus 6 Medial frontal gyrus 8 9 Paraterminal gyrus / Paraolfactory area 12 Straight gyrus 11 Orbital gyri / Orbitofrontal cortex 10 11 12 Ventromedial prefrontal cortex 10 Subcallosal area 25 Olfactory sulcus Orbital sulcus Precentral Paracentral lobule Paracentral sulcus Both Primary motor cortex Premotor cortex 6 Supplementary motor area 6 Supplementary eye field 6 Frontal eye fields 8 Parietal lobe Superolateral Superior parietal lobule 5 7 Inferior parietal lobule 40 - Supramarginal gyrus 39 - Angular gyrus Parietal operculum 43 Intraparietal sulcus Medial / inferior Paracentral lobule 5 Precuneus 7 Marginal sulcus Both Postcentral gyrus / Primary somatosensory cortex Secondary somatosensory cortex 5 Posterior parietal cortex 7 Occipital lobe Superolateral Occipital pole of cerebrum Lateral occipital gyrus 18 19 Lunate sulcus Transverse occipital sulcus Medial / inferior Visual cortex 17 Cuneus Lingual gyrus Calcarine sulcus Temporal lobe Superolateral Transverse temporal gyrus / Auditory cortex 41 42 Superior temporal gyrus 38 22 / Wernicke 's area Middle temporal gyrus 21 Superior temporal sulcus Medial / inferior Fusiform gyrus 37 Medial temporal lobe 27 28 34 35 36 Inferior temporal gyrus 20 Inferior temporal sulcus Interlobar sulci / fissures Superolateral Central ( frontal + parietal ) Lateral ( frontal + parietal + temporal ) Parieto - occipital Preoccipital notch Medial / inferior Longitudinal fissure Cingulate ( frontal + cingulate ) Collateral ( temporal + occipital ) Callosal sulcus Limbic lobe Parahippocampal gyrus anterior Entorhinal cortex Perirhinal cortex Postrhinal cortex Posterior parahippocampal gyrus Prepyriform area Cingulate cortex / gyrus Subgenual area 25 Anterior cingulate 24 32 33 Posterior cingulate 23 31 Isthmus of cingulate gyrus : Retrosplenial cortex 26 29 30 Hippocampal formation Hippocampal sulcus Fimbria of hippocampus Dentate gyrus Rhinal sulcus Other Supracallosal gyrus Uncus Amygdala Insular cortex Insular cortex General Operculum Poles of cerebral hemispheres Some categorizations are approximations, and some Brodmann areas span gyri. Retrieved from `` https://en.wikipedia.org/w/index.php?title=Prefrontal_cortex&oldid=825335710 '' Categories : Cerebral cortex Frontal lobe Hidden categories : Pages with unresolved properties CS1 maint : Multiple names : authors list Wikipedia articles needing page number citations from June 2014 Anatomy infobox template using unsupported parameters Infobox brain using components parameter Infobox brain using braininfo parameter Wikipedia articles in need of updating from March 2017 All Wikipedia articles in need of updating All articles with unsourced statements Articles with unsourced statements from March 2012 Talk Contents About Wikipedia Català Dansk Deutsch Eesti Español Français Italiano עברית Nederlands 日本 語 Polski Português Русский Simple English Slovenščina Svenska ไทย Türkçe 中文 11 more Edit links This page was last edited on 12 February 2018, at 20 : 37. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. 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Question: what part of the brain controls self image
Answer: prefrontal cortex