Gluconeogenesis - wikipedia Gluconeogenesis Not to be confused with Glycogenesis or Glyceroneogenesis. Simplified Gluconeogenesis Pathway Gluconeogenesis ( GNG ) is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. From breakdown of proteins, these substrates include glucogenic amino acids ( although not ketogenic amino acids ) ; from breakdown of lipids ( such as triglycerides ), they include glycerol ( although not fatty acids ) ; and from other steps in metabolism they include pyruvate and lactate. Gluconeogenesis is one of several main mechanisms used by humans and many other animals to maintain blood glucose levels, avoiding low levels ( hypoglycemia ). Other means include the degradation of glycogen ( glycogenolysis ) and fatty acid catabolism. Gluconeogenesis is a ubiquitous process, present in plants, animals, fungi, bacteria, and other microorganisms. In vertebrates, gluconeogenesis takes place mainly in the liver and, to a lesser extent, in the cortex of the kidneys. In ruminants, this tends to be a continuous process. In many other animals, the process occurs during periods of fasting, starvation, low - carbohydrate diets, or intense exercise. The process is highly endergonic until it is coupled to the hydrolysis of ATP or GTP, effectively making the process exergonic. For example, the pathway leading from pyruvate to glucose - 6 - phosphate requires 4 molecules of ATP and 2 molecules of GTP to proceed spontaneously. Gluconeogenesis is often associated with ketosis. Gluconeogenesis is also a target of therapy for type 2 diabetes, such as the antidiabetic drug, metformin, which inhibits glucose formation and stimulates glucose uptake by cells. In ruminants, because dietary carbohydrates tend to be metabolized by rumen organisms, gluconeogenesis occurs regardless of fasting, low - carbohydrate diets, exercise, etc. Contents 1 Precursors 2 Location 3 Pathway 4 Regulation 5 See also 6 References 7 External links Precursors Catabolism of proteinogenic amino acids. Amino acids are classified according to the abilities of their products to enter gluconeogenesis : Glucogenic amino acids have this ability Ketogenic amino acids do not. These products may still be used for ketogenesis or lipid synthesis. Some amino acids are catabolized into both glucogenic and ketogenic products. In humans the main gluconeogenic precursors are lactate, glycerol ( which is a part of the triacylglycerol molecule ), alanine and glutamine. Altogether, they account for over 90 % of the overall gluconeogenesis. Other glucogenic amino acids as well as all citric acid cycle intermediates, the latter through conversion to oxaloacetate, can also function as substrates for gluconeogenesis. In ruminants, propionate is the principal gluconeogenic substrate. Generally, consumption of gluconeogenic substrates in food does not result in increased gluconeogenesis. Lactate is transported back to the liver where it is converted into pyruvate by the Cori cycle using the enzyme lactate dehydrogenase. Pyruvate, the first designated substrate of the gluconeogenic pathway, can then be used to generate glucose. Transamination or deamination of amino acids facilitates entering of their carbon skeleton into the cycle directly ( as pyruvate or oxaloacetate ), or indirectly via the citric acid cycle. The contribution of Cori cycle lactate to overall glucose production increases with fasting duration. Specifically, after 12, 20, and 40 hours of fasting by human volunteers, the contribution of Cori cycle lactate to gluconeogenesis was 41 %, 71 %, and 92 %, respectively. Whether even - chain fatty acids can be converted into glucose in animals has been a longstanding question in biochemistry. It is known that odd - chain fatty acids can be oxidized to yield propionyl - CoA, a precursor for succinyl - CoA, which can be converted to pyruvate and enter into gluconeogenesis. In plants, specifically seedlings, the glyoxylate cycle can be used to convert fatty acids ( acetate ) into the primary carbon source of the organism. The glyoxylate cycle produces four - carbon dicarboxylic acids that can enter gluconeogenesis. In 1995, researchers identified the glyoxylate cycle in nematodes. In addition, the glyoxylate enzymes malate synthase and isocitrate lyase have been found in animal tissues. Genes coding for malate synthase have been identified in other metazoans including arthropods, echinoderms, and even some vertebrates. Mammals found to possess these genes include monotremes ( platypus ) and marsupials ( opossum ) but not placental mammals. Genes for isocitrate lyase are found only in nematodes, in which, it is apparent, they originated in horizontal gene transfer from bacteria. The existence of glyoxylate cycles in humans has not been established, and it is widely held that fatty acids can not be converted to glucose in humans directly. However, carbon - 14 has been shown to end up in glucose when it is supplied in fatty acids. Despite these findings, it is considered unlikely that the 2 - carbon acetyl - CoA derived from the oxidation of fatty acids would produce a net yield of glucose via the citric acid cycle -- however, acetyl - CoA can be converted into pyruvate and lactate through the ketogenic pathway. Put simply, acetic acid ( in the form of acetyl - CoA ) is used to partially produce glucose ; acetyl groups can only form part of the glucose molecules ( not the 5th carbon atom ) and require extra substrates ( such as pyruvate ) in order to form the rest of the glucose molecule. But a roundabout pathway does lead from acetyl - coA to pyruvate, via acetoacetate, acetone, hydroxyacetone ( acetol ) and then either propylene glycol or methylglyoxal. Location In mammals, gluconeogenesis has been believed to be restricted to the liver, the kidney, the intestine, and muscle, but recent evidence indicates gluconeogenesis occurring in astrocytes of the brain. These organs use somewhat different gluconeogenic precursors. The liver preferentially uses lactate, alanine and glycerol ( especially alanine ) while the kidney preferentially uses lactate, glutamine and glycerol ( especially glutamine ). Lactate from the Cori cycle is quantitatively the largest source of substrate for gluconeogenesis, especially for the kidney. The liver uses both glycogenolysis and gluconeogenesis to produce glucose, whereas the kidney only uses gluconeogenesis. After a meal, the liver shifts to glycogen synthesis, whereas the kidney increases gluconeogenesis. The intestine uses mostly glutamine and glycerol. Propionate is the principal substrate for gluconeogenesis in the ruminant liver, and the ruminant liver may make increased use of gluconeogenic amino acids, e.g. alanine, when glucose demand is increased. The capacity of liver cells to use lactate for gluconeogenesis declines from the preruminant stage to the ruminant stage in calves and lambs. In sheep kidney tissue, very high rates of gluconeogenesis from propionate have been observed. In all species, the formation of oxaloacetate from pyruvate and TCA cycle intermediates is restricted to the mitochondrion, and the enzymes that convert Phosphoenolpyruvic acid ( PEP ) to glucose are found in the cytosol. The location of the enzyme that links these two parts of gluconeogenesis by converting oxaloacetate to PEP -- PEP carboxykinase ( PEPCK ) -- is variable by species : it can be found entirely within the mitochondria, entirely within the cytosol, or dispersed evenly between the two, as it is in humans. Transport of PEP across the mitochondrial membrane is accomplished by dedicated transport proteins ; however no such proteins exist for oxaloacetate. Therefore, in species that lack intra-mitochondrial PEPCK, oxaloacetate must be converted into malate or aspartate, exported from the mitochondrion, and converted back into oxaloacetate in order to allow gluconeogenesis to continue. Gluconeogenesis pathway with key molecules and enzymes. Many steps are the opposite of those found in the glycolysis. Pathway Gluconeogenesis is a pathway consisting of a series of eleven enzyme - catalyzed reactions. The pathway will begin in either the liver or kidney, in the mitochondria or cytoplasm of those cells, this being dependent on the substrate being used. Many of the reactions are the reverse of steps found in glycolysis. Gluconeogenesis begins in the mitochondria with the formation of oxaloacetate by the carboxylation of pyruvate. This reaction also requires one molecule of ATP, and is catalyzed by pyruvate carboxylase. This enzyme is stimulated by high levels of acetyl - CoA ( produced in β - oxidation in the liver ) and inhibited by high levels of ADP and glucose. Oxaloacetate is reduced to malate using NADH, a step required for its transportation out of the mitochondria. Malate is oxidized to oxaloacetate using NAD in the cytosol, where the remaining steps of gluconeogenesis take place. Oxaloacetate is decarboxylated and then phosphorylated to form phosphoenolpyruvate using the enzyme PEPCK. A molecule of GTP is hydrolyzed to GDP during this reaction. The next steps in the reaction are the same as reversed glycolysis. However, fructose 1, 6 - bisphosphatase converts fructose 1, 6 - bisphosphate to fructose 6 - phosphate, using one water molecule and releasing one phosphate ( in glycolysis, phosphofructokinase 1 converts F6P and ATP to F1, 6BP and ADP ). This is also the rate - limiting step of gluconeogenesis. Glucose - 6 - phosphate is formed from fructose 6 - phosphate by phosphoglucoisomerase ( the reverse of step 2 in glycolysis ). Glucose - 6 - phosphate can be used in other metabolic pathways or dephosphorylated to free glucose. Whereas free glucose can easily diffuse in and out of the cell, the phosphorylated form ( glucose - 6 - phosphate ) is locked in the cell, a mechanism by which intracellular glucose levels are controlled by cells. The final reaction of gluconeogenesis, the formation of glucose, occurs in the lumen of the endoplasmic reticulum, where glucose - 6 - phosphate is hydrolyzed by glucose - 6 - phosphatase to produce glucose and release an inorganic phosphate. Like two steps prior, this step is not a simple reversal of glycolysis, in which hexokinase catalyzes the conversion of glucose and ATP into G6P and ADP. Glucose is shuttled into the cytoplasm by glucose transporters located in the endoplasmic reticulum 's membrane. Metabolism of common monosaccharides, including glycolysis, gluconeogenesis, glycogenesis and glycogenolysis Regulation While most steps in gluconeogenesis are the reverse of those found in glycolysis, three regulated and strongly endergonic reactions are replaced with more kinetically favorable reactions. Hexokinase / glucokinase, phosphofructokinase, and pyruvate kinase enzymes of glycolysis are replaced with glucose - 6 - phosphatase, fructose - 1, 6 - bisphosphatase, and PEP carboxykinase / pyruvate carboxylase. These enzymes are typically regulated by similar molecules, but with opposite results. For example, acetyl CoA and citrate activate gluconeogenesis enzymes ( pyruvate carboxylase and fructose - 1, 6 - bisphosphatase, respectively ), while at the same time inhibiting the glycolytic enzyme pyruvate kinase. This system of reciprocal control allow glycolysis and gluconeogenesis to inhibit each other and prevents a futile cycle of synthesizing glucose to only break it down. The majority of the enzymes responsible for gluconeogenesis are found in the cytosol ; the exceptions are mitochondrial pyruvate carboxylase and, in animals, phosphoenolpyruvate carboxykinase. The latter exists as an isozyme located in both the mitochondrion and the cytosol. The rate of gluconeogenesis is ultimately controlled by the action of a key enzyme, fructose - 1, 6 - bisphosphatase, which is also regulated through signal transduction by cAMP and its phosphorylation. Global control of gluconeogenesis is mediated by glucagon ( released when blood glucose is low ) ; it triggers phosphorylation of enzymes and regulatory proteins by Protein Kinase A ( a cyclic AMP regulated kinase ) resulting in inhibition of glycolysis and stimulation of gluconeogenesis. Recent studies have shown that the absence of hepatic glucose production has no major effect on the control of fasting plasma glucose concentration. Compensatory induction of gluconeogenesis occurs in the kidneys and intestine, driven by glucagon, glucocorticoids, and acidosis. See also Bioenergetics References Jump up ^ Silva, Pedro. `` The Chemical Logic Behind Gluconeogenesis ''. Archived from the original on August 26, 2009. Retrieved September 8, 2009. 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External links Overview at indstate.edu Interactive diagram at uakron.edu The chemical logic behind gluconeogenesis metpath : Interactive representation of gluconeogenesis Metabolism, catabolism, anabolism General Metabolic pathway Metabolic network Primary nutritional groups Energy metabolism Aerobic respiration Glycolysis → Pyruvate decarboxylation → Citric acid cycle → Oxidative phosphorylation ( electron transport chain + ATP synthase ) Anaerobic respiration Electron acceptors are other than oxygen Fermentation Glycolysis → Substrate - level phosphorylation ABE Ethanol Lactic acid Specific paths Protein metabolism Protein synthesis Catabolism Carbohydrate metabolism ( carbohydrate catabolism and anabolism ) Human Glycolysis ⇄ Gluconeogenesis Glycogenolysis ⇄ Glycogenesis Pentose phosphate pathway Fructolysis Galactolysis Glycosylation N - linked O - linked Nonhuman Photosynthesis Anoxygenic photosynthesis Chemosynthesis Carbon fixation Xylose metabolism Radiotrophism Lipid metabolism ( lipolysis, lipogenesis ) Fatty acid metabolism Fatty acid degradation ( Beta oxidation ) Fatty acid synthesis Other Steroid metabolism Sphingolipid metabolism Eicosanoid metabolism Ketosis Reverse cholesterol transport Amino acid Amino acid synthesis Urea cycle Nucleotide metabolism Purine metabolism Nucleotide salvage Pyrimidine metabolism Other Metal metabolism Iron metabolism Ethanol metabolism Metabolism : carbohydrate metabolism : glycolysis / gluconeogenesis enzymes Glycolysis Hexokinase ( HK1, HK2, HK3, Glucokinase ) → / Glucose 6 - phosphatase ← Glucose isomerase Phosphofructokinase 1 ( Liver, Muscle, Platelet ) → / Fructose 1, 6 - bisphosphatase ← Fructose - bisphosphate aldolase ( Aldolase A, B, C ) Triosephosphate isomerase Glyceraldehyde 3 - phosphate dehydrogenase Phosphoglycerate kinase Phosphoglycerate mutase Enolase Pyruvate kinase ( PKLR, PKM2 ) Gluconeogenesis only to oxaloacetate : Pyruvate carboxylase Phosphoenolpyruvate carboxykinase from lactate ( Cori cycle ) : Lactate dehydrogenase from alanine ( Alanine cycle ) : Alanine transaminase from glycerol : Glycerol kinase Glycerol dehydrogenase Regulatory Fructose 6 - P, 2 - kinase : fructose 2, 6 - bisphosphatase PFKFB1, PFKFB2, PFKFB3, PFKFB4 Bisphosphoglycerate mutase Metabolism map Carbon Fixation Photo - respiration Pentose Phosphate Pathway Citric Acid Cycle Glyoxylate Cycle Urea Cycle Fatty Acid Synthesis Fatty Acid Elongation Beta Oxidation Peroxisomal Beta Oxidation Glyco - genolysis Glyco - genesis Glyco - lysis Gluconeo - genesis Decarb - oxylation Fermentation Keto - lysis Keto - genesis feeders to Gluconeo - genesis Direct / C4 / CAM Carbon Intake Light Reaction Oxidative Phosphorylation Amino Acid Deamination Citrate Shuttle Lipogenesis Lipolysis Steroidogenesis MVA Pathway MEP Pathway Shikimate Pathway Transcription & Replication Translation Proteolysis Glycosy - lation Sugar Acids Double / Multiple Sugars & Glycans Simple Sugars Inositol - P Amino Sugars & Sialic Acids Nucleotide Sugars Hexose - P Triose - P Glycerol P - glycerates Pentose - P Tetrose - P Propionyl - CoA Succinate Acetyl - CoA Pentose - P P - glycerates Glyoxylate Photosystems Pyruvate Lactate Acetyl - CoA Citrate Oxalo - acetate Malate Succinyl - CoA α - Keto - glutarate Ketone Bodies Respiratory Chain Serine Group Alanine Branched - chain Amino Acids Aspartate Group Homoserine Group & Lysine Glutamate Group & Proline Arginine Creatine & Polyamines Ketogenic & Glucogenic Amino Acids Amino Acids Shikimate Aromatic Amino Acids & Histidine Ascorbate ( Vitamin C ) δ - ALA Bile Pigments Hemes Cobalamins ( Vitamin B ) Various Vitamin B 's Calciferols ( Vitamin D ) Retinoids ( Vitamin A ) Quinones ( Vitamin K ) & Carotenoids ( Vitamin E ) Cofactors Vitamins & Minerals Antioxidants PRPP Nucleotides Nucleic Acids Proteins Glycoproteins & Proteoglycans Chlorophylls MEP MVA Acetyl - CoA Polyketides Terpenoid Backbones Terpenoids & Carotenoids ( Vitamin A ) Cholesterol Bile Acids Glycero - phospholipids Glycerolipids Acyl - CoA Fatty Acids Glyco - sphingolipids Sphingolipids Waxes Polyunsaturated Fatty Acids Neurotransmitters & Thyroid Hormones Steroids Endo - cannabinoids Eicosanoids Major metabolic pathways in metro - style map. Click any text ( name of pathway or metabolites ) to link to the corresponding article. Single lines : pathways common to most lifeforms. Double lines : pathways not in humans ( occurs in e.g. plants, fungi, prokaryotes ). Orange nodes : carbohydrate metabolism. Violet nodes : photosynthesis. Red nodes : cellular respiration. Pink nodes : cell signaling. Blue nodes : amino acid metabolism. Grey nodes : vitamin and cofactor metabolism. Brown nodes : nucleotide and protein metabolism. Green nodes : lipid metabolism. Metabolism portal Retrieved from `` https://en.wikipedia.org/w/index.php?title=Gluconeogenesis&oldid=838074688 '' Categories : Metabolism Biochemistry Metabolic pathways Carbohydrates Glycobiology Exercise physiology Hepatology Diabetes Hidden categories : All articles with unsourced statements Articles with unsourced statements from March 2018 Talk Contents About Wikipedia Български Bosanski Català Čeština Dansk Deutsch Español Euskara فارسی Français Galego 한국어 Hrvatski Bahasa Indonesia Italiano עברית Қазақша Lietuvių Македонски Bahasa Melayu Nederlands 日本 語 Norsk Polski Português Русский Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska ไทย Türkçe Українська 粵語 中文 27 more Edit links This page was last edited on 24 April 2018, at 19 : 27. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. 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Question: where does gluconeogenesis take place in eukaryotic cells
Answer: liver