Beriberi - wikipedia Beriberi `` Beri beri '' redirects here. For the African ethnic group, see Kanuri people. Beriberi A sufferer from beriberi at the beginning of the 20th century in Southeast Asia. Specialty Neurology, cardiology, pediatrics ( edit on Wikidata ) Beriberi refers to symptoms caused by thiamine ( vitamin B1 ) deficiency. Beriberi has conventionally been divided into three separate entities, relating to the body system mainly involved ( peripheral nervous system or cardiovascular ) or age of person ( like infantile ). Beriberi is one of several thiamine - deficiency related conditions, which may occur concurrently, including Wernicke 's encephalopathy ( mainly affecting the central nervous system ), Korsakoff 's syndrome ( amnesia with additional psychiatric manifestations ), and Wernicke -- Korsakoff syndrome ( with both neurologic and psychiatric symptoms ). Historically, beriberi has been common in regions where polished or white rice forms a major part of the diet, which has its husk removed to extend its shelf life and improve its palatability, but has the side effect of removing the primary source of thiamine. It was not known until the end of the 19th century that polishing rice was associated with beriberi. Contents 1 Signs and symptoms 1.1 Dry beriberi 1.2 Wet beriberi 1.3 Infantile beriberi 1.4 Gastrointestinal beriberi 2 Cause 3 Pathophysiology 4 Treatment 5 Epidemiology 6 History 6.1 Etymology 6.2 Identification 7 References 8 External links Signs and symptoms Symptoms of beriberi include weight loss, emotional disturbances, impaired sensory perception, weakness and pain in the limbs, and periods of irregular heart rate. Edema ( swelling of bodily tissues ) is common. It may increase the amount of lactic acid and pyruvic acid within the blood. In advanced cases, the disease may cause high - output cardiac failure and death. Symptoms may occur concurrently with those of Wernicke 's encephalopathy, a primarily neurological thiamine - deficiency related condition. Beriberi is divided into four categories as follows. The first three are historical and the fourth, gastrointestinal beriberi, was recognized in 2004 : Dry beriberi specially affects the peripheral nervous system Wet beriberi specially affects the cardiovascular system and other bodily systems Infantile beriberi affects the children of malnourished mothers Gastrointestinal beriberi affects the digestive system and other bodily systems Dry beriberi Dry beriberi causes wasting and partial paralysis resulting from damaged peripheral nerves. It is also referred to as endemic neuritis. It is characterized by : Difficulty in walking Tingling or loss of sensation ( numbness ) in hands and feet Loss of tendon reflexes Loss of muscle function or paralysis of the lower legs Mental confusion / speech difficulties Pain Involuntary eye movements ( nystagmus ) Vomiting. A selective impairment of the large proprioceptive sensory fibers without motor impairment can occur and present as a prominent sensory ataxia, which is a loss of balance and coordination due to loss of the proprioceptive inputs from the periphery and loss of position sense. Wet beriberi Wet beriberi affects the heart and circulatory system. It is sometimes fatal, as it causes a combination of heart failure and weakening of the capillary walls, which causes the peripheral tissues to become edematous. Wet beriberi is characterized by : Increased heart rate Vasodilation leading to decreased systemic vascular resistance, and high output cardiac failure Elevated jugular venous pressure Dyspnea ( shortness of breath ) on exertion Paroxysmal nocturnal dyspnea Peripheral edema ( swelling of lower legs ) Infantile beriberi Infantile beriberi usually occurs between two and six months of age in children whose mothers have inadequate thiamine intake. In the acute form, the baby develops dyspnea and cyanosis and soon dies of heart failure. These symptoms may be described in infantile beriberi : Hoarseness, where the child makes moves to moan but emits no sound or just faint moans caused by nerve paralysis Weight loss, becoming thinner and then marasmic as the disease progresses Vomiting Diarrhea Pale skin Edema Ill temper Alterations of the cardiovascular system, especially tachycardia ( rapid heart rate ) Convulsions occasionally observed in the terminal stages Gastrointestinal beriberi Gastrointestinal beriberi causes abdominal pain. Gastrointestinal beriberi is characterized by : Abdominal pain Nausea Vomiting Lactic acidosis Cause Beriberi may also be caused by shortcomings other than inadequate intake : diseases or operations on the digestive tract, alcoholism, dialysis, genetic deficiencies, etc. All these causes mainly affect the central nervous system, and provoke the development of what is known as Wernicke 's disease or Wernicke 's encephalopathy. Wernicke 's disease is one of the most prevalent neurological or neuropsychiatric diseases. In autopsy series, features of Wernicke lesions are observed in approximately 2 % of general cases. Medical record research shows that about 85 % had not been diagnosed, although only 19 % would be asymptomatic. In children, only 58 % were diagnosed. In alcohol abusers, autopsy series showed neurological damages at rates of 12.5 % or more. Mortality caused by Wernicke 's disease reaches 17 % of diseases, which means 3.4 / 1000 or about 25 million contemporaries. The number of people with Wernicke 's disease may be even higher, considering that early stages may have dysfunctions prior to the production of observable lesions at necropsy. In addition, uncounted numbers of people can experience fetal damage and subsequent diseases. Pathophysiology Thiamine in the human body has a half - life of 18 days and is quickly exhausted, particularly when metabolic demands exceed intake. A derivative of thiamine, thiamine pyrophosphate ( TPP ), is a cofactor involved in the citric acid cycle, as well as connecting the breakdown of sugars with the citric acid cycle. The citric acid cycle is a central metabolic pathway involved in the regulation of carbohydrate, lipid, and amino acid metabolism, and its disruption due to thiamine deficiency inhibits the production of many molecules including the neurotransmitters glutamic acid and GABA. Additionally thiamine may also be directly involved in neuromodulation. Treatment Many people with beriberi can be treated with thiamine alone. Given thiamine intravenously ( and later orally ), rapid and dramatic recovery can occur within hours. In situations where concentrated thiamine supplements are unavailable, feeding the person with a thiamine - rich diet ( e.g. whole grain brown bread ) will lead to recovery, though at a much slower rate. Epidemiology Historically, beriberi was associated with a diet including much polished rice ( white rice ) ; when the relationship between polishing rice and the disease was discovered, it became possible to prevent and treat the deficiency condition, for example with inexpensive rice bran. Beriberi caused by inadequate nutritional intake is rare today in developed countries because of quality of food and the fact that many foods are fortified with vitamins. No reliable statistics are given for beriberi in developed countries in the 19th century or earlier ; neither are statistics available before the last century in countries in extreme poverty. Beriberi is a recurrent nutritional disease in detention houses, even in this century. In 1999, an outbreak of beriberi occurred in a detention center in Taiwan. High rates of illness and death in overcrowded Haitian jails were traced in 2007 to the traditional practice of washing rice before cooking. In the Ivory Coast, among a group of prisoners with heavy punishment, 64 % were affected by beriberi. Before beginning treatment, prisoners exhibited symptoms of dry or wet beriberi with neurological signs ( swarming : 41 % ), cardiovascular signs ( dyspnoea : 42 %, thoracic pain : 35 % ), and edemas of the lower limbs ( 51 % ). With treatment the rate of healing was about 97 %. Populations under extreme stress may be at higher risk for beriberi. Displaced populations, such as refugees from war, are susceptible to micronutritional deficiency, including beriberi. The severe nutritional deprivation caused by famine also can cause beriberis, although symptoms may be overlooked in clinical assessment or masked by other famine - related problems. An extreme weight - loss diet can, rarely, induce a famine - like state and the accompanying beriberi. History Etymology According to the Oxford English Dictionary, the term `` beriberi '' comes from a Sinhalese phrase meaning `` weak, weak '' or `` I can not, I can not '', the word being duplicated for emphasis. According to Jacobus Bontius ( Jacob de Bondt ; 1591 -- 1631 ), a Dutch physician who encountered the disease while working in Java in 1630, In the first known description of beriberi ( or, beri - beri ), he wrote : `` A certain very troublesome affliction, which attacks men, is called by the inhabitants beriberi ( which means sheep ). I believe those, whom this same disease attacks, with their knees shaking and the legs raised up, walk like sheep. It is a kind of paralysis, or rather tremor : for it penetrates the motion and sensation of the hands and feet indeed sometimes of the whole body. '' Identification Sun Simiao ( 581 -- 682 AD ) was the first person in medical history to document the diagnosis, treatment, and prevention of Beriberi ( leg edema due to vitamin B1 deficiency ), a deficiency disease caused by lack of vitamin B1. For this, he prescribed combinations of herbs rich in vitamin B1 and unpolished rice ( the outer layer of rice and other grains rich in B vitamins ) In the late 19th century, beriberi was studied by Takaki Kanehiro, a British - trained Japanese medical doctor of the Japanese Navy. Beriberi was a serious problem in the Japanese navy : Sailors fell ill an average of four times a year in the period 1878 to 1881, and 35 % were cases of beriberi. In 1883, Kanehiro learned of a very high incidence of beriberi among cadets on a training mission from Japan to Hawaii, via New Zealand and South America. The voyage lasted more than nine months and resulted in 169 cases of sickness and 25 deaths on a ship of 376 men. With the support of the Japanese Navy, he conducted an experiment in which another ship was deployed on the same route, except that its crew was fed a diet of meat, fish, barley, rice, and beans. At the end of the voyage, this crew had only 14 cases of beriberi and no deaths. This convinced Kanehiro and the Japanese Navy that diet was the cause. In 1884, Kanehiro observed that beriberi was endemic among low - ranking crew who were often provided free rice and thus ate little else, but not among crews of Western navies, nor among Japanese officers who consumed a more varied diet. In 1897, Christiaan Eijkman, a Dutch physician and pathologist, demonstrated that beriberi is caused by poor diet, and discovered that feeding unpolished rice ( instead of the polished variety ) to chickens helped to prevent beriberi. The following year, Sir Frederick Hopkins postulated that some foods contained `` accessory factors '' -- in addition to proteins, carbohydrates, fats, and salt -- that were necessary for the functions of the human body. In 1901, Gerrit Grijns ( May 28, 1865 -- November 11, 1944 ), a Dutch physician and assistant to Christiaan Eijkman in the Netherlands, correctly interpreted the disease as a deficiency syndrome, and between 1910 and 1913, Edward Bright Vedder established that an extract of rice bran is a treatment for beriberi. In 1929, Eijkman and Hopkins were awarded the Nobel Prize for Physiology or Medicine for their discoveries. References Jump up ^ Kennedy, Ron ( 2013 ). `` Doctors ' Medical Library -- Beriberi ( Thiamine Deficiency ) ( B1 Deficiency ) ''. ^ Jump up to : Katsura, E. ; Oiso, T. ( 1976 ). Beaton, G.H. ; Bengoa, J.M., eds. `` Chapter 9. Beriberi '' ( PDF ). World Health Organization Monograph Series No. 62 : Nutrition in Preventive Medicine. Geneva : World Health Organization. Jump up ^ Spinazzi, Marco ; Angelini, Corrado ; Patrini, Cesare ( 2010 ). `` Subacute sensory ataxia and optic neuropathy with thiamine deficiency ''. Nature Reviews Neurology. 6 ( 5 ) : 288 -- 93. PMID 20308997. doi : 10.1038 / nrneurol. 2010.16. Jump up ^ Anand, I.S. ; Florea, V.G. ( 2001 ). `` High Output Cardiac Failure ''. Current Treatment Options in Cardiovascular Medicine. 3 ( 2 ) : 151 -- 159. PMID 11242561. doi : 10.1007 / s11936 - 001 - 0070 - 1. ^ Jump up to : McIntyre, Neil ; Stanley, Nigel N. ( 1971 ). `` Cardiac Beriberi : Two Modes of Presentation ''. BMJ. 3 ( 5774 ) : 567 -- 9. PMC 1798841. PMID 5571454. doi : 10.1136 / bmj. 3.5774. 567. ^ Jump up to : Latham, Michael C. ( 1997 ). `` Chapter 16. Beriberi and thiamine deficiency ''. Human nutrition in the developing world ( Food and Nutrition Series -- No. 29 ). Rome : Food and Agriculture Organization of the United Nations ( FAO ). ISSN 1014 - 3181. Jump up ^ Donnino M ( 2004 ). `` Gastrointestinal Beriberi : A Previously Unrecognized Syndrome ''. Ann Intern Med. 141 : 898 -- 899. doi : 10.7326 / 0003 - 4819 - 141 - 11 - 200412070 - 00035. Jump up ^ Duca, J., Lum, C., & Lo, A. ( 2015 ). Elevated Lactate Secondary to Gastrointestinal Beriberi. J GEN INTERN MED Journal of General Internal Medicine Jump up ^ Cernicchiaro, Luis ( 2007 ), Enfermedad de Wernicke ( o Encefalopatía de Wernicke ). Monitoring an acute and recovered case for twelve years. ( Wernicke  ́ s Disease ( or Wernicke  ́ s Encephalopathy ) ) ( in Spanish ) Jump up ^ Salen, Philip N ( 1 March 2013 ). Kulkarni, Rick, ed. `` Wernicke Encephalopathy ''. Medscape. Jump up ^ Harper, CG ; Giles, M ; Finlay - Jones, R ( April 1986 ). `` Clinical signs in the Wernicke - Korsakoff complex : a retrospective analysis of 131 cases diagnosed at necropsy ''. J Neurol Neurosurg Psychiatry. 49 ( 4 ) : 341 -- 5. PMC 1028756. PMID 3701343. doi : 10.1136 / jnnp. 49.4. 341. Jump up ^ Harper, C ( March 1979 ). `` Wernicke 's encephalopathy : a more common disease than realised. A neuropathological study of 51 cases ''. J Neurol Neurosurg Psychiatry. 42 ( 3 ) : 226 -- 31. PMC 490724. PMID 438830. doi : 10.1136 / jnnp. 42.3. 226. Jump up ^ Sechi, G ; Serra, A ( May 2007 ). `` Wernicke 's encephalopathy : new clinical settings and recent advances in diagnosis and management ''. Lancet neurology. 6 ( 5 ) : 442 -- 55. PMID 17434099. doi : 10.1016 / S1474 - 4422 ( 07 ) 70104 - 7. Jump up ^ Hirsch, JA ; Parrott, J ( 2012 ). `` New considerations on the neuromodulatory role of thiamine ''. Pharmacology. 89 ( 1 -- 2 ) : 111 -- 6. PMID 22398704. doi : 10.1159 / 000336339. Jump up ^ Nguyen - Khoa, Dieu - Thu Beriberi ( Thiamine Deficiency ) Treatment & Management. Mescape Jump up ^ Chen KT, Twu SJ, Chiou ST, Pan WH, Chang HJ, Serdula MK ( 2003 ). `` Outbreak of beriberi among illegal mainland Chinese immigrants at a detention center in Taiwan ''. Public Health Rep. 118 : 59 -- 64. PMC 1497506. PMID 12604765. doi : 10.1093 / phr / 118.1. 59. Jump up ^ Sprague, Jeb ; Alexandra, Eunida ( 17 January 2007 ). `` Haiti : Mysterious Prison Ailment Traced to U.S. Rice ''. Inter Press Service. Jump up ^ Aké - Tano, O. ; Konan, E.Y. ; Tetchi, E.O. ; Ekou, F.K. ; Ekra, D. ; Coulibaly, A. ; Dagnan, N.S. ( 2011 ). `` Le béribéri, maladie nutritionnelle récurrente en milieu carcéral en Côte - d'Ivoire ''. Bulletin de la Société de pathologie exotique. 104 ( 5 ) : 347 -- 351. doi : 10.1007 / s13149 - 011 - 0136 - 6. Jump up ^ Prinzo, Z. Weise ; de Benoist, B. ( 2009 ). `` Meeting the challenges of micronutrient deficiencies in emergency - affected populations '' ( PDF ). Proceedings of the Nutrition Society. 61 ( 2 ) : 251 -- 7. PMID 12133207. doi : 10.1079 / PNS2002151. Jump up ^ Golden, Mike ( May 1997 ). `` Diagnosing Beriberi in Emergency Situations ''. Field Exchange ( 1 ) : 18. Jump up ^ Oxford English Dictionary : `` Beri - beri... a Cingalese word, f. beri weakness, the reduplication being intensive... '', page 203, 1937 Jump up ^ A Sinhalese - English Dictionary, Rev. Charles Carter : `` බැරි බැරි. රෝගය, a. the diseaseberi beri, a form of neuritis accompanied by dropsy &c... '', page 448, 1924 Jump up ^ Beriberi, Information about Beriberi. faqs.org Jump up ^ `` Beriberi ''. Online Etymology Dictionary. Retrieved 8 July 2013. Jump up ^ Berg, Jeremy M ; Tymoczko, John L ; Stryer, Lubert ( 2002 ). `` The Disruption of Pyruvate Metabolism Is the Cause of Beriberi and Poisoning by Mercury and Arsenic ''. Biochemistry ( 5th ed. ). ISBN 978 - 0 - 7167 - 3051 - 4. Jump up ^ http://www.pss.org.sg/whats-happening/e-bulletin/issue-no-30/lessons-sun-si-miao-chinese-patron-deity-physicians#.WWTQI2gxXMI Jump up ^ http://www.shen-nong.com/eng/history/suitang.html Jump up ^ http://www.itmonline.org/arts/sunsimiao.htm Jump up ^ King Sun Simiao of the medicine twenty - nine Achivement ^ Jump up to : Itokawa, Yoshinori ( 1976 ). `` Kanehiro Takaki ( 1849 -- 1920 ) : A Biographical Sketch ''. Journal of Nutrition. 106 ( 5 ) : 581 -- 8. PMID 772183. Jump up ^ Challem, Jack ( 1997 ). `` The Past, Present and Future of Vitamins ''. Archived from the original on 8 June 2010. Jump up ^ Christiaan Eijkman, Beriberi and Vitamin B1, Nobelprize.org, Nobel Media AB, retrieved 8 July 2013 Jump up ^ Grijns, G. ( 1901 ). `` Over polyneuritis gallinarum ''. Geneeskundig Tijdschrift voor Nederlandsch - Indie. 43 : 3 -- 110. External links Classification V T D ICD - 10 : E51. 1 ICD - 9 - CM : 265.0 MeSH : D001602 DiseasesDB : 14107 External resources MedlinePlus : 000339 eMedicine : ped / 229 med / 221 Patient UK : Beriberi Wikimedia Commons has media related to Beriberi. Malnutrition or nutrition disorders ( E40 -- E68, 260 -- 269 ) Malnutrition Protein - energy malnutrition Kwashiorkor Marasmus Catabolysis Vitamin deficiency B vitamins B : Beriberi / Wernicke -- Korsakoff syndrome ( Wernicke 's encephalopathy Korsakoff 's syndrome ) B : Riboflavin deficiency B : Pellagra ( Niacin deficiency ) B : Pyridoxine deficiency B : Biotin deficiency B : Folate deficiency B : Vitamin B deficiency Other vitamins A : Vitamin A deficiency / Bitot 's spots C : Scurvy D: Vitamin D deficiency / Rickets / Osteomalacia E : Vitamin E deficiency K : Vitamin K deficiency Mineral deficiency Sodium Potassium Magnesium Calcium Iron Zinc Manganese Copper Iodine Chromium Molybdenum Selenium ( Keshan disease ) Overnutrition Overweight Obesity Childhood obesity Obesity hypoventilation syndrome Abdominal obesity Vitamin poisoning Hypervitaminosis A Hypervitaminosis D Hypervitaminosis E Mineral overload see inborn errors of metal metabolism, toxicity NDL : 00564727 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Beriberi&oldid=803424728 '' Categories : Reduplicants Vitamin deficiencies Thiamine Hidden categories : CS1 Spanish - language sources ( es ) All articles lacking reliable references Articles lacking reliable references from July 2012 All articles with unsourced statements Articles with unsourced statements from June 2013 Articles with unsourced statements from July 2013 Articles needing more detailed references Articles with unsourced statements from April 2012 Talk Contents About Wikipedia Afrikaans Azərbaycanca تۆرکجه বাংলা Беларуская Български Català Čeština Dansk Deutsch Eesti Español Esperanto Euskara فارسی Føroyskt Français Gaeilge Galego 한국어 Հայերեն हिन्दी Hrvatski Ido Bahasa Indonesia Italiano עברית ქართული Қазақша Latina Magyar Македонски မြန်မာဘာသာ Nederlands 日本 語 Norsk Oʻzbekcha / ўзбекча Polski Português Русский Scots Simple English Slovenščina Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska Tagalog தமிழ் తెలుగు ไทย Türkçe Українська 中文 Edit links This page was last edited on 2 October 2017, at 13 : 15. 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Question: beri beri is a disease caused by the deficiency of
Answer: thiamine (vitamin B1)