Renal corpuscle - wikipedia Renal corpuscle This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. ( May 2015 ) Renal corpuscle The structure on the left in blue and pink is the renal corpuscle. The structure on the right is the renal tubule. The blue structure ( A ) is the Bowman 's capsule ( 2 and 3 ). The pink structure is the glomerulus with its capillaries. At the left, blood flows from the afferent areteriole ( 9 ), through the capillaries ( 10 ), and out the efferent arteriole ( 11 ). The mesangium is the pink structure inside the glomerulus between the capillaries ( 5a ) and extending outside the glomerulus ( 5b ). Description A - Renal corpuscle B - Proximal tubule C - Distal convoluted tubule D - Juxtaglomerular apparatus 1. Basement membrane ( Basal lamina ) 2. Bowman 's capsule - parietal layer 3. Bowman 's capsule - visceral layer 3a. Pedicels ( podocytes ) 3b. Podocyte 4. Bowman 's space ( urinary space ) 5a. Mesangium - Intraglomerular cell 5b. Mesangium - Extraglomerular cell 6. Granular cells ( Juxtaglomerular cells ) 7. Macula densa 8. Myocytes ( smooth muscle ) 9. Afferent arteriole 10. Glomerulus Capillaries 11. Efferent arteriole The renal corpuscle in the cortex ( outer layer ) of the kidney. At the top, the renal corpuscle containing the glomerulus. The filtered blood exits into the renal tubule as filtrate, at right. At left, blood flows from the afferent arteriole ( red ), enters into the renal corpuscle and is filtered in the glomerulus ; blood flows out of the efferent arteriole ( blue ). Details Identifiers Latin corpusculum renis FMA 15625 Anatomical terminology ( edit on Wikidata ) A renal corpuscle is the blood - filtering component of the nephron of the kidney. It consists of a glomerulus - a tuft of capillaries composed of endothelial cells, and a glomerular capsule known as Bowman 's capsule. Contents 1 Structure 2 Eponym 3 Additional images 4 References 5 External links Structure The renal corpuscle is composed of two structures, the glomerulus and the Bowman 's capsule. The glomerulus is a small tuft of capillaries containing two cell types. Endothelial cells, which have large fenestrae, are not covered by diaphragms. Mesangial cells are modified smooth muscle cells that lie between the capillaries. They regulate blood flow by their contractile activity and secrete extracellular matrix, prostaglandins, and cytokines. Mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier. The Bowman 's capsule has an outer parietal layer composed of simple squamous epithelium. The visceral layer, composed of modified simple squamous epithelium, is lined by podocytes. Podocytes have foot processes, pedicels, that wrap around glomerular capillaries. These pedicels interdigitate with pedicels of adjacent podocytes forming filtration slits. The renal corpuscle filtration barrier is composed of : the fenestrated endothelium of glomerular capillaries, the fused basal lamina of endothelial cells and podocytes, and the filtration slits of the podocytes. This barrier permits passage of water, ions, and small molecules from the bloodstream into Bowman 's space ( the space between the visceral and parietal layers ). Large and / or negatively charged proteins are prevented from passing into Bowman 's space, thus retaining these proteins in the circulation. The basal lamina is composed of 3 layers : lamina rara externa, lamina densa, and lamina rara interna. The lamina rara externa is adjacent to the podocyte processes. The lamina densa is the central layer consisting of type IV collagen and laminin. This layer acts as a selective macromolecular filter, preventing the passage of large protein molecules into Bowman 's space. The lamina rara interna is adjacent to endothelial cells. This layer contains heparan sulfate, a negatively charged glycosaminoglycan that contributes to the electrostatic barrier of the glomerular filter. There are two poles in the renal corpuscle, a vascular pole, and a urinary pole. The vascular pole is a location of the glomerulus. At the vascular pole, the afferent arterioles and efferent arterioles enter and leave the glomerulus in the Bowman 's capsule. The urinary pole is at the other end opposite to the vascular pole. At the urinary pole, the proximal convoluted tubule arises. Fluid from blood in the glomerulus is collected in the Bowman 's capsule to form `` glomerular filtrate '', which is then further processed along the nephron to form urine. Eponym A renal corpuscle is also known as a Malpighian corpuscle, named after Marcello Malpighi ( 1628 -- 1694 ), an Italian physician and biologist. This name is no longer widely used, probably to avoid confusion with a Malpighian corpuscle in the spleen. Additional images Glomerulus is red ; Bowman 's capsule is pink. Outline of function of renal corpuscle Vascular and urinary poles References Jump up ^ J., Tortora, Gerard ( 2010 ). Principles of anatomy and physiology. Derrickson, Bryan. ( 12th ed ed. ). Hoboken, NJ : John Wiley & Sons. p. 1024. ISBN 9780470233474. OCLC 192027371. CS1 maint : Extra text ( link ) Jump up ^ `` Renal corpuscle ''. External links Wikimedia Commons has media related to Renal corpuscle. Histology image : 16003loa -- Histology Learning System at Boston University MedEd at Loyola Histo / practical / kidney / hp16 - 53. html Anatomy of the urinary system Kidneys Layers Fascia Capsule Cortex column Medulla sinus pyramids medullary interstitium Lobe Cortical lobule Medullary ray Nephron Circulation Arteries Renal artery segmental interlobar arcuate interlobular afferent Veins Renal vein Peritubular capillaries Vasa recta arcuate interlobar efferent Nephron Renal corpuscle Glomerulus Bowman 's capsule Glomerular basement membrane Podocyte Filtration slits Mesangium Intraglomerular mesangial cell Renal tubule Proximal convoluted tubule Loop of Henle Descending Thin ascending Thick ascending Distal convoluted tubule Connecting tubule Collecting ducts Tubular fluid Renal papilla Minor calyx Major calyx Renal pelvis Juxtaglomerular apparatus Macula densa Juxtaglomerular cells Mesangium Extraglomerular mesangial cell Ureters Orifice of ureter Ureteropelvic junction Bladder Apex Uvula Neck Median umbilical ligament Muscular layer Trigone Detrusor Mucosa Submucosa Urethra Urethral sphincters External sphincter male female Internal sphincter Retrieved from `` https://en.wikipedia.org/w/index.php?title=Renal_corpuscle&oldid=801896042 '' Categories : Kidney anatomy Hidden categories : CS1 maint : Extra text Articles lacking sources from May 2015 All articles lacking sources Medicine infobox template using GraySubject or GrayPage Talk Contents About Wikipedia Català Deutsch Eesti Español فارسی 한국어 Italiano Magyar Nederlands 日本 語 Polski Português Suomi 中文 Edit links This page was last edited on 22 September 2017, at 16 : 24. 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Question: what are the components of the renal corpuscle
Answer: glomerulus