Thallium poisoning - wikipedia Thallium poisoning Thallium poisoning Thallium Classification and external resources Specialty emergency medicine ICD - 10 T60. 4 ICD - 9 - CM 985.8 DiseasesDB 13009 ( edit on Wikidata ) Thallium and its compounds are often highly toxic. Contact with skin is dangerous, and adequate ventilation should be provided when melting this metal. Many thallium ( I ) compounds are highly soluble in water and are readily absorbed through the skin. Exposure to them should not exceed 0.1 mg per m of skin in an 8 - hour time - weighted average ( 40 - hour work week ). Thallium is a suspected human carcinogen. Part of the reason for thallium 's high toxicity is that, when present in aqueous solution as the univalent thallium ( I ) ion ( Tl ), it exhibits some similarities with essential alkali metal cations, particularly potassium ( due to similar ionic radii ). It can thus enter the body via potassium uptake pathways. Other aspects of thallium 's chemistry differ strongly from that of the alkali metals, such as its high affinity for sulfur ligands. Thus, this substitution disrupts many cellular processes ( for instance, thallium may attack sulfur - containing proteins such as cysteine residues and ferredoxins ). Thallium 's toxicity has led to its use ( now discontinued in many countries ) as a rat and ant poison. Among the distinctive effects of thallium poisoning are hair loss ( which led to its initial use as a depilatory before its toxicity was properly appreciated ) and damage to peripheral nerves ( victims may experience a sensation of walking on hot coals ), although the loss of hair only generally occurs in low doses ; in high doses the thallium kills before this can take effect. Thallium was once an effective murder weapon before its effects became understood and an antidote ( Prussian blue ) discovered. Indeed, thallium poisoning has been called the `` poisoner 's poison '' since thallium is colorless, odorless and tasteless ; its slow - acting, painful and wide - ranging symptoms are often suggestive of a host of other illnesses and conditions. Contents 1 Treatment and internal decontamination 2 Bioconcentration 3 Thallium compounds 4 Detection in body fluids 5 Famous uses as a poison 5.1 Australia 's `` Thallium Craze '' 5.2 Other notable cases 5.3 In fiction 6 References 7 External links 8 See also Treatment and internal decontamination There are two main methods of removing both radioactive and stable isotopes of thallium from humans. First known was to use Prussian blue, which is a solid ion exchange material, which absorbs thallium. Up to 20 g per day of Prussian blue is fed by mouth to the person, and it passes through their digestive system and comes out in the stool. Hemodialysis and hemoperfusion are also used to remove thallium from the blood serum. At later stage of the treatment additional potassium is used to mobilize thallium from the tissue. Bioconcentration According to the United States Environmental Protection Agency ( EPA ), thallium release to the environment was reported in Texas and Ohio. This may indicate bioconcentration in aquatic ecosystems. ( 2 ) Thallium compounds The odorless and tasteless thallium sulfate was also used as rat poison and ant killer. Since 1975, this use in the United States and many other countries is prohibited due to safety concerns. Detection in body fluids Thallium may be quantitated in blood or urine as a diagnostic tool in clinical poisoning situations or to aid in the medicolegal investigation of suspicious deaths. Normal background blood and urine concentrations in healthy persons are usually less than 1 μg / litre, but they are often in the 1 -- 10 mg / litre range in survivors of acute intoxication. Famous uses as a poison There are numerous recorded cases of fatal thallium poisoning. Because of its use for murder, thallium has gained the nicknames `` The Poisoner 's Poison '' and `` Inheritance Powder '' ( alongside arsenic ). Australia 's `` thallium craze '' In Australia, in the early 1950s, there was a notable spate of cases of murder or attempted murder by thallium poisoning. At this time, due to the chronic rat infestation problems in overcrowded inner - city suburbs ( notably in Sydney ), and thallium 's effectiveness as a rat poison, it was still readily available over the counter in New South Wales, where thallium sulphate was marketed as a commercial rat bait, under the brand `` Thall - rat ''. In September 1952, Yvonne Gladys Fletcher, a housewife and mother of two from the inner Sydney suburb of Newtown, was charged and tried for the murders of both her first husband, Desmond Butler ( who died in 1948 ) and her abusive second husband, Bertrand `` Bluey '' Fletcher, a rat bait layer, from whom Yvonne had obtained the thallium poison that she used to kill him earlier that year. Suspicions were raised after it became obvious to friends and neighbours that Bluey Fletcher was suffering from the same fatal illness that had killed Yvonne 's first husband. A police investigation led to the exhumation and testing of Desmond Butler 's remains, which showed clear evidence of thallium, and this led to Yvonne being convicted of Butler 's murder. She was sentenced to death, but this was subsequently commuted to life imprisonment after the NSW Government abolished the death penalty ; she was eventually released in 1964. At the time of the trial, it was reported that this was the first known case in Australia of a person being convicted of murder by administering thallium. The Fletcher case is also notable for the fact that one of the arresting officers was Sydney detective Fred Krahe, who later became notorious for his suspected close involvement with elements of Sydney 's organised crime scene and his alleged involvement in the disappearance of social activist Juanita Nielsen. A month later, in October 1952, Bathurst grandmother Ruby Norton was tried for the murder of her daughter 's fiancė Allen Williams, who died of thallium poisoning at Cowra Hospital in July 1952. Despite allegations that Norton hated all the men in her family and Williams was an unwanted son - in - law, Norton was acquitted. In 1953, Sydney woman Veronica Monty, 45, was tried for the attempted murder of her son - in - law, noted Balmain and Australian rugby league player Bob Lulham, who was treated for thallium poisoning in 1952. After separating from her husband, Monty had moved in with her daughter Judy and Judy 's husband, Bob Lulham. The sensational trial revealed that Lulham and Monty had an `` intimate relationship '' while Lulham 's wife was at Sunday mass. Monty was found not guilty ; Judy Lulham divorced her husband as a result of the revelations about his affair, and Veronica Monty killed herself with thallium in 1955. In July 1953, Sydney woman Beryl Hague was tried for `` maliciously administering thallium and endangering her husband 's life ''. Hague confessed to buying Thall - rat from a corner shop and putting it in her husband 's tea, because she wanted to `` give him a headache to repay the many headaches he had given me '' in violent disputes In 1953, Australian Caroline Grills was sentenced to life in prison after three family members and a close family friend died. Authorities found thallium in tea that she had given to two additional family members. Grills spent the rest of her life in Sydney 's Long Bay Gaol, where fellow inmates dubbed her `` Aunt Thally ''. The Australian TV documentary Recipe for Murder, released in 2011, examined three of the most sensational and widely reported Australian thallium poisonings, the Fletcher, Monty and Grills cases. Other notable cases Félix - Roland Moumié, a Cameroonian leader, was assassinated in Geneva on 3 November 1960 by the SDECE ( French secret service ) with thallium. In 1971, thallium was the main poison that Graham Frederick Young used to poison around 70 people in the English village of Bovingdon, Hertfordshire, of whom three died. From 1976 to late 1979, thallium was used as a chemical warfare agent, most notably by a unit of the British South Africa Police ( BSAP ) attached to the Selous Scouts during the Rhodesian Bush War. In 1977, a 19 - month - old girl living in Qatar fell ill due to thallium poisoning ( from pesticides used by her parents ). While doctors were unable to identify the cause, a nurse named Marsha Maitland managed to do it from the description of the symptoms given in The Pale Horse. In 1987, in Kiev, a woman named Tamara Ivanutina was arrested along with her older sister and parents. They were found guilty of 40 cases of poisoning ( 13 of them lethal ) with Clerici solution obtained from an acquaintance working at a geology institute. Tamara ( guilty of nine deaths, including four children ) was executed ; one of the three documented cases of women receiving the capital punishment in post-Stalin Soviet Union. Her relatives received prison terms, the parents dying in jail. In 1988, members of the Carr family from Alturas, Polk County, Florida, fell ill from what appeared to be thallium poisoning. Peggy Carr, the mother, died slowly and painfully from the poison. Her son and stepson were critically ill but eventually recovered. The Carrs ' neighbor, chemist George J. Trepal, was convicted of murdering Mrs. Carr and attempting to murder her family and sentenced to death. The thallium was slipped into bottles of Coca - Cola at the Carr and Trepal homes. Thallium was the poison of choice for Saddam Hussein to use on dissidents, which even allowed for them to emigrate before dying. In 1995, Zhu Ling was the victim of an unsolved attempted thallium poisoning in Beijing, China. In 1994, Zhu Ling was a sophomore studying Physical Chemistry at Tsinghua University in Beijing. She began to show strange and debilitating symptoms at the end of 1994, when she reported experiencing acute stomach pain and extensive hair loss. Ultimately she was diagnosed on Usenet with poisoning by thallium. To this day, there is still speculation as to the poisoner 's identity among Chinese expatriates overseas. The primary ( and only ) suspect of the police investigation, Sun Wei, is a member of a family with high - level political connections, which may have been used to halt and suppress the results of the investigation. Sun Wei was Zhu Ling 's classmate and roommate in Tsinghua University from 1992 to 1997. Tsinghua University also said she was the only student who had access to thallium compound at the school. The investigation 's results have never been released to Zhu Ling 's parents or the general public. However, Tsinghua University declined to issue Sun Wei 's B.S. certificate and refused to provide her with the documentation needed to get a passport or visa in 1997. In 1999, Norwegian Terje Wiik was sentenced to 21 years prison for poisoning his girlfriend with thallium. In June 2004, 25 Russian soldiers earned Honorable Mentions in the Darwin Awards after becoming ill from thallium exposure when they found a can of mysterious white powder in a rubbish dump on their base at Khabarovsk in the Russian Far East. Oblivious to the danger of misusing an unidentified white powder from a military dump site, the conscripts added it to tobacco, and used it as a substitute for talcum powder on their feet. In 2005, a 17 - year - old girl in Izunokuni, Shizuoka, Japan admitted to attempting to murder her mother by lacing her tea with thallium, causing a national scandal. In February 2007, two Americans, Marina and Yana Kovalevsky, a mother and daughter, visiting Russia were hospitalized for thallium poisoning. Both had emigrated from the Soviet Union to the United States in 1991 and had made several trips to Russia since then. In February 2008, members of an Iraqi air force club and some of their children were poisoned by cake laced with thallium. Two of the children died. In 2011, a chemist at Bristol - Myers Squibb in New Jersey, Li Tianle, was charged with the murder of her husband. According to an investigation by the Middlesex County Prosecutor 's Office, Li Tianle was able to obtain a chemical containing thallium and fed it to her husband. Li was a chemistry student at Beijing University at the time of the highly publicized thallium poisoning of Zhu Ling in 1995 at neighboring Tsinghua University. In 2012 a chemistry postgraduate student at the University of Southampton, UK, was found to be suffering from the effects of thallium and arsenic poisoning after presenting with neurological symptoms. The student underwent an intensive course of treatment and -- although they have shown improvement -- faces an uncertain long - term prognosis for the recovery of full locomotion. Urine screening revealed elevated thallium levels in a small number of other members of the chemistry department, though none were at toxic levels. The source of the poisoning remains unknown, and although police investigations were fruitless, foul play is strongly suspected. In fiction Ngaio Marsh used thallium acetate in her 1947 detective novel, Final Curtain. It was being used legitimately for scalp problems in a group of school children just after World War Two, housed in a private estate. A relative living there used it in place of the heart medicine intended for the owner. Agatha Christie, who worked as a pharmacist, used thallium in 1961 as the agent of murder in her detective fiction novel The Pale Horse -- the first clue to the murder method coming from the hair loss of the victims. This novel is notable as being credited with having saved at least two lives after readers recognised the symptoms of thallium poisoning that Christie described. The Pale Horse was found among possessions of convicted thallium poisoner George Trepal 's wife, the orthopedic surgeon Dr. Diana Carr ( see above ), who was herself considered a suspect in the Peggy Carr ( no relation ) murder for a time. In Nigel Williams ' 1990 novel The Wimbledon Poisoner, Henry Far uses thallium to baste a roast chicken in a failed attempt to murder his wife. Thallium figures prominently in the 1995 film The Young Poisoner 's Handbook, a dark comedy loosely based on the life of Graham Frederick Young. In Big Nothing, Josie is the Wyoming Widow ; a murderer who befriended men and killed them with whiskey laced with highly concentrated thallium. In the 2010 episode `` Whatever It Takes '' of House, a character uses thallium to poison a patient to mimic the effects of polio, then appear to cure it with ultra high doses of vitamin C. In the NCIS episode `` Dead Man Walking '' ( 2007 ), thallium - laced cigars are used to murder a Naval officer. `` Page Turner '', a 2008 episode of CSI : NY, has radioactive thallium poisoning as its central theme. In the 2010 film Edge of Darkness, thallium is used to poison both the main character and his daughter. In the 2015 James Bond Film SPECTRE, the organisation of the same name used thallium to poison ' Mr White ' by lacing his mobile ( cell ) phone with it. In Season 3 of Royal Pains, the mysterious German billionaire Boris Kuester von Jurgens - Ratenicz was poisoned by thallium added to his pool 's water. Drop Dead Diva episode `` Ashes to Ashes '', thallium was used to murder a client 's husband, affecting the client when she ate the cremation remains. In 2016 TVB drama Two Steps From Heaven, thallium was used to poison Bosco Wong 's character. References ^ Jump up to : Thallium Toxicity at eMedicine ^ Jump up to : `` Biology of Thallium ''. webelemnts. Retrieved 2008 - 11 - 11. Jump up ^ A Homogenous Thallium Flux Assay for High Throughput Screen of Potassium Channels Jump up ^ Eliminating Thallium ( poisoning ) Jump up ^ Blum, The Poisoner 's Handbook, 256 Jump up ^ Douglas, K.T. ; Bunni, M.A. ; Baindur, S.R. ( 1990 ). `` Thallium in biochemistry ''. International Journal of Biochemistry. 22 ( 5 ) : 429 -- 438. doi : 10.1016 / 0020 - 711X ( 90 ) 90254 - Z. Jump up ^ Amy Ellis Nutt & Sue Epstein, A 15 - year - old case yields a timely clue in deadly thallium poisoning, The Star - Ledger, February 13, 2011 Jump up ^ Prussian blue fact sheet from the Centers for Disease Control and Prevention Jump up ^ Malbrain, M.L. ; Lambrecht, G.L. ; Zandijk, E. ; Demedts, P.A. ; Neels, H.M. ; Lambert, W. ; de Leenheer, A.P. ; Lins, R.L. ; Daelemans, R. ( 1997 ). `` Treatment of Severe Thallium Intoxication ''. Clinical Toxicology. 35 ( 1 ) : 97 -- 100. PMID 9022660. doi : 10.3109 / 15563659709001173. Jump up ^ `` Chemical fact sheet -- Thallium ''. Spectrum Laboratories. April 2001. Retrieved 2008 - 02 - 02. Jump up ^ Zhao, Guohua ; Ding, Meiping ; Zhang, Baorong ; Lv, Wen ; Yin, Houmin ; Zhang, Liang ; Ying, Zhilin ; Zhang, Qiong ( 2008 ). `` Clinical Manifestations and Management of Acute Thallium Poisoning ''. European Neurology. 60 ( 6 ) : 292 -- 7. PMID 18824857. doi : 10.1159 / 000157883. Jump up ^ Baselt, Randall Clint ( 2008 ). Disposition of Toxic Drugs and Chemicals in Man ( 8th ed. ). Foster City, CA : Biomedical Publications. pp. 1522 -- 4. Jump up ^ http://www.nj.com/news/index.ssf/2011/02/thallium_is_favored_method_of.html Jump up ^ Sydney Morning Herald, 24 September 1952. Retrieved 31 January 2013. ^ Jump up to : Marea Donnelly, `` Post-war days of thallium and old lace '', Daily Telegraph, 23 May 2011. Retrieved 31 January 2013. Jump up ^ What is thallium ?, BBC, November 19, 2006. Retrieved November 21, 2006. Jump up ^ Marea Donnelly, `` Post-war days of thallium and old lace '', Daily Telegraph, 23 May 2011 Jump up ^ Cavanagh, J.B. ( 1991 ). `` What have we learnt from Graham Frederick Young ? Reflections on the mechanism of thallium neurotoxicity ''. Neuropathology and Applied Neurobiology. 17 ( 1 ) : 3 -- 9. doi : 10.1111 / j. 1365 - 2990.1991. tb00687. x. Jump up ^ Glenn Cross, `` Dirty War : Rhodesia and Chemical Biological Warfare, 1975 - 1980, '' Solihull, UK : Helion & Company ( 2017 ) Jump up ^ The Elements of Murder : A History of Poison Jump up ^ Tamara Ivanyutina and Her Family of Serial Killers - Bizarrepedia Jump up ^ `` The Case of TREPAL, George ( W / M ) ''. The Commission on Capital Cases. Retrieved 2007 - 11 - 29. Jump up ^ https://www.google.com/#q=thallium+saddam Jump up ^ White Russians at DarwinAwards.com Jump up ^ Ruling on Japan poison - diary girl, `` BBC News '', Monday, 1 May 2006. Jump up ^ Embassy Confirms Hospitalization of Two Americans for Thallium Poisoning, Foxnews.com, March 7, 2007. Retrieved March 7, 2007. Jump up ^ Poison cake kills Iraqi children, news.bbc.co.uk, February 9, 2008. Retrieved February 9, 2008. Jump up ^ ( 1 ) NBC New York, February 8, 2011. Jump up ^ A 15 - year - old case yields a timely clue in deadly thallium poisoning, NJ.com News, February 13, 2011. Jump up ^ `` Southampton University labs shut after student poisoning ''. BBC News. 14 September 2012. Retrieved 8 June 2017. Jump up ^ Aronson, Jeff ( 2007 ). `` When I use a word : Colourful metals ''. British Medical Journal. 334 ( 334 ) : 205. doi : 10.1136 / bmj.39091.708981.BE. Jump up ^ Huntley, Kristine. `` CSI : NEW YORK -- ' PAGE TURNER ' ''. csifiles.com. Retrieved 2 May 2014. External links Look up thallium in Wiktionary, the free dictionary. Slow - acting killer that was Saddam 's favourite instrument of vengeance NLM Hazardous Substances Databank -- Thallium, Elemental ( 3 ) Cyril Wecht, Thallium, Robert Curley ATSDR - ToxFAQs The Guardian reports : Two Iraqi children die from Thallium poisoning : 9 February 2008 Poisoning Toxicity Overdosing ( T36 -- T65, 960 -- 989 ) History of poison Inorganic Metals Toxic metals Beryllium Cadmium Lead Mercury Nickel Silver Thallium Tin Dietary minerals Chromium Cobalt Copper Iron Manganese Zinc Metalloids Arsenic Nonmetals Sulfuric acid Selenium Chlorine Fluoride Organic Phosphorus Pesticides Aluminium phosphide Organophosphates Nitrogen Cyanide Nicotine Nitrogen dioxide poisoning CHO alcohol Ethanol Ethylene glycol Methanol Carbon monoxide Oxygen Toluene Pharmaceutical Drug overdoses Nervous Anticholinesterase Aspirin Barbiturates Benzodiazepines Opioids Paracetamol Tricyclic antidepressants Cardiovascular Digoxin Dipyridamole Vitamin poisoning Vitamin A Vitamin D Vitamin E Biological Fish / seafood Ciguatera Haff disease Ichthyoallyeinotoxism Scombroid Shellfish poisoning Amnesic Diarrhetic Neurotoxic Paralytic Other vertebrates amphibian venom Batrachotoxin Bombesin Bufotenin Physalaemin birds / quail Coturnism snake venom Alpha - Bungarotoxin Ancrod Batroxobin Arthropods Arthropod bites and stings bee sting / bee venom Apamin Melittin scorpion venom Charybdotoxin spider venom Latrotoxin / Latrodectism Loxoscelism tick paralysis Plants / fungi Cinchonism Ergotism Lathyrism Locoism Mushrooms Strychnine including venoms, toxins, foodborne illnesses. See also Wikimedia Commons has media related to Thallium. Glenn Cross ( 2017 ), Dirty War : Rhodesia and Chemical Biological Warfare, 1975 - 1980, Solihull : Helion & Company Retrieved from `` https://en.wikipedia.org/w/index.php?title=Thallium_poisoning&oldid=784824464 '' Categories : Thallium Toxic effects of metals Hidden categories : All articles with unsourced statements Articles with unsourced statements from September 2010 Articles with unsourced statements from June 2017 Talk Contents About Wikipedia Italiano Русский 中文 Edit links This page was last edited on 10 June 2017, at 08 : 47. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: why thallium is known as the poisoner's poison
Answer: Because of its use for murder