Vagus nerve - wikipedia Vagus nerve Vagus nerve Plan of the upper portions of the glossopharyngeal, vagus, and accessory nerves. Course and distribution of the glossopharyngeal, vagus, and accessory nerves. Details Innervates Levator veli palatini, Salpingopharyngeus, Palatoglossus, Palatopharyngeus, Superior pharyngeal constrictor, Middle pharyngeal constrictor, visceratyppi, Inferior pharyngeal constrictor, viscera rass Identifiers Latin nervus vagus MeSH D014630 NeuroNames 702 TA A14. 2.01. 153 FMA 5731 Anatomical terms of neuroanatomy ( edit on Wikidata ) Cranial nerves CN 0 -- Terminal CN I -- Olfactory CN II -- Optic CN III -- Oculomotor CN IV -- Trochlear CN V -- Trigeminal CN VI -- Abducens CN VII -- Facial CN VIII -- Vestibulocochlear CN IX -- Glossopharyngeal CN X -- Vagus CN XI -- Accessory CN XII -- Hypoglossal Overview Table The vagus nerve ( / ˈveɪɡəs / VAY - gəs ), historically cited as the pneumogastric nerve, is the tenth cranial nerve or CN X, and interfaces with parasympathetic control of the heart, lungs, and digestive tract. The vagus nerves are paired, however they are normally referred to in the singular. It is the longest nerve of the autonomic nervous system in the human body. The vagus nerve also has a sympathetic function via the peripheral chemoreceptors. Contents 1 Structure 1.1 Nuclei 2 Development 3 Function 3.1 Sympathetic function 3.2 Vagus nerve and the heart 3.3 Physical and emotional effects 4 Clinical significance 4.1 Vagus nerve stimulation 4.2 Vagotomy 4.3 Chagas disease 5 History 5.1 Etymology 6 Additional illustrations 7 See also 8 References 9 External links Structure Upon leaving the medulla oblongata between the pyramid and the inferior cerebellar peduncle, the vagus nerve extends through the jugular foramen, then passes into the carotid sheath between the internal carotid artery and the internal jugular vein down to the neck, chest, and abdomen, where it contributes to the innervation of the viscera, reaching all the way to the colon. Besides giving some output to various organs, the vagus nerve comprises between 80 % and 90 % of afferent nerves mostly conveying sensory information about the state of the body 's organs to the central nervous system. The right and left vagus nerves descend from the cranial vault through the jugular foramina, penetrating the carotid sheath between the internal and external carotid arteries, then passing posterolateral to the common carotid artery. The cell bodies of visceral afferent fibers of the vagus nerve are located bilaterally in the inferior ganglion of the vagus nerve ( nodose ganglia ). The right vagus nerve gives rise to the right recurrent laryngeal nerve, which hooks around the right subclavian artery and ascends into the neck between the trachea and esophagus. The right vagus then crosses anterior to the right subclavian artery, runs posterior to the superior vena cava, descends posterior to the right main bronchus, and contributes to cardiac, pulmonary, and esophageal plexuses. It forms the posterior vagal trunk at the lower part of the esophagus and enters the diaphragm through the esophageal hiatus. The left vagus nerve enters the thorax between left common carotid artery and left subclavian artery and descends on the aortic arch. It gives rise to the left recurrent laryngeal nerve, which hooks around the aortic arch to the left of the ligamentum arteriosum and ascends between the trachea and esophagus. The left vagus further gives off thoracic cardiac branches, breaks up into the pulmonary plexus, continues into the esophageal plexus, and enters the abdomen as the anterior vagal trunk in the esophageal hiatus of the diaphragm. Pharyngeal nerve Superior laryngeal nerve Superior cervical cardiac branches of vagus nerve Inferior cervical cardiac branch Recurrent laryngeal nerve Thoracic cardiac branches Branches to the pulmonary plexus Branches to the esophageal plexus Anterior vagal trunk Posterior vagal trunk Hering - Breuer reflex in alveoli The vagus runs parallel to the common carotid artery and internal jugular vein inside the carotid sheath. Nuclei The vagus nerve includes axons which emerge from or converge onto four nuclei of the medulla : The dorsal nucleus of vagus nerve -- which sends parasympathetic output to the viscera, especially the intestines The nucleus ambiguus -- which gives rise to the branchial efferent motor fibers of the vagus nerve and preganglionic parasympathetic neurons that innervate the heart The solitary nucleus -- which receives afferent taste information and primary afferents from visceral organs The spinal trigeminal nucleus -- which receives information about deep / crude touch, pain, and temperature of the outer ear, the dura of the posterior cranial fossa and the mucosa of the larynx Development The motor division of the vagus nerve is derived from the basal plate of the embryonic medulla oblongata, while the sensory division originates from the cranial neural crest. Function The vagus nerve supplies motor parasympathetic fibers to all the organs ( except the adrenal glands ), from the neck down to the second segment of the transverse colon. The vagus also controls a few skeletal muscles, including : Cricothyroid muscle Levator veli palatini muscle Salpingopharyngeus muscle Palatoglossus muscle Palatopharyngeus muscle Superior, middle and inferior pharyngeal constrictors Muscles of the larynx ( speech ). This means that the vagus nerve is responsible for such varied tasks as heart rate, gastrointestinal peristalsis, sweating, and quite a few muscle movements in the mouth, including speech ( via the recurrent laryngeal nerve ). It also has some afferent fibers that innervate the inner ( canal ) portion of the outer ear ( via the auricular branch, also known as Alderman 's nerve ) and part of the meninges. This explains why a person may cough when tickled on the ear, such as when trying to remove ear wax with a cotton swab. Efferent vagus nerve fibers innervating the pharynx and back of the throat are responsible for the gag reflex. In addition, 5 - HT receptor - mediated afferent vagus stimulation in the gut due to gastroenteritis is a cause of vomiting. Stimulation of the vagus nerve in the cervix uteri ( as in some medical procedures ) can lead to a vasovagal response. The vagus nerve also plays a role in satiation following food consumption. Knocking out vagal nerve receptors has been shown to cause hyperphagia ( greatly increased food intake ). Sympathetic function The vagus nerve also has a sympathetic function via the peripheral chemoreceptors. Peripheral chemoreceptors are activated primarily due to hypoxemia. When stimulated, these chemoreceptors relay impulses throughout the vagus nerves in order to enable a vasoconstrictor response and increase blood pressure. Vagus nerve and the heart H&E stained fibers of the vagus nerve ( bottom right ) innervate the sinoatrial node tissue ( middle left ) Parasympathetic innervation of the heart is partially controlled by the vagus nerve and is shared by the thoracic ganglia. Vagal and spinal ganglionic nerves mediate the lowering of the heart rate. The right vagus branch innervates the sinoatrial node. In healthy people, parasympathetic tone from these sources are well - matched to sympathetic tone. Hyperstimulation of parasympathetic influence promotes bradyarrhythmias. When hyperstimulated, the left vagal branch predisposes the heart to conduction block at the atrioventricular node. At this location, neuroscientist Otto Loewi first demonstrated that nerves secrete substances called neurotransmitters, which have effects on receptors in target tissues. In his experiment, Loewi electrically stimulated the vagus nerve of a frog heart, which slowed the heart. Then he took the fluid from the heart and transferred it to a second frog heart without a vagus nerve. The second heart slowed down without an electrical stimulation. Loewi described the substance released by the vagus nerve as vagusstoff, which was later found to be acetylcholine. Drugs that inhibit the muscarinic receptors ( anticholinergics ) such as atropine and scopolamine, are called vagolytic because they inhibit the action of the vagus nerve on the heart, gastrointestinal tract, and other organs. Anticholinergic drugs increase heart rate and are used to treat bradycardia. Physical and emotional effects Excessive activation of the vagal nerve during emotional stress, which is a parasympathetic overcompensation of a strong sympathetic nervous system response associated with stress, can also cause vasovagal syncope due to a sudden drop in cardiac output, causing cerebral hypoperfusion. Vasovagal syncope affects young children and women more than other groups. It can also lead to temporary loss of bladder control under moments of extreme fear. Research has shown that women having had complete spinal cord injury can experience orgasms through the vagus nerve, which can go from the uterus, cervix, and, it is presumed, the vagina to the brain. Insulin signaling activates the adenosine triphosphate ( ATP ) - sensitive potassium ( KATP ) channels in the arcuate nucleus, decreases AgRP release, and through the vagus nerve, leads to decreased glucose production by the liver by decreasing gluconeogenic enzymes : Phosphoenolpyruvate carboxykinase, Glucose 6 - phosphatase. Clinical significance Vagus nerve stimulation Main article : Vagus nerve stimulation Vagus nerve stimulation ( VNS ) therapy using a neurostimulator implanted in the chest is a treatment used since 1997 to control seizures in epilepsy patients and has been approved for treating drug - resistant cases of clinical depression. A non-invasive VNS device that stimulates an afferent branch of the vagus nerve is also being developed and will soon undergo trials. Clinical trials are underway in Antwerp, Belgium, using VNS for the treatment of tonal tinnitus after a breakthrough study published in early 2011 by researchers at the University of Texas - Dallas showed successful tinnitus suppression in rats when tones were paired with brief pulses of stimulation of the vagus nerve. VNS may also be achieved by one of the vagal maneuvers : holding the breath for a few seconds, dipping the face in cold water, coughing, or tensing the stomach muscles as if to bear down to have a bowel movement. Patients with supraventricular tachycardia, atrial fibrillation, and other illnesses may be trained to perform vagal maneuvers ( or find one or more on their own ). Vagus nerve blocking ( VBLOC ) therapy is similar to VNS but used only during the day. In a six - month open - label trial involving three medical centers in Australia, Mexico, and Norway, vagus nerve blocking has helped 31 obese participants lose an average of nearly 15 percent of their excess weight. A year - long 300 - participant double - blind, phase II trial has begun. Vagotomy Vagotomy ( cutting of the vagus nerve ) is a now - obsolete therapy that was performed for peptic ulcer disease. Vagotomy is currently being researched as a less invasive alternative weight - loss procedure to gastric bypass surgery. The procedure curbs the feeling of hunger and is sometimes performed in conjunction with putting bands on patients ' stomachs, resulting in average weight loss of 43 % at six months with diet and exercise. One serious side effect of a vagotomy is a vitamin B deficiency later in life -- perhaps after about 10 years -- that is similar to pernicious anemia. The vagus normally stimulates the stomach 's parietal cells to secrete acid and intrinsic factor. Intrinsic factor is needed to absorb vitamin B from food. The vagotomy reduces this secretion and ultimately leads to the deficiency, which, if left untreated, causes nerve damage, tiredness, dementia, paranoia, and ultimately death. Researchers from Aarhus University and Aarhus University Hospital have demonstrated that vagotomy prevents ( halves the risk of ) the development of Parkinson 's disease, suggesting that Parkinson 's disease begins in the gastrointestinal tract and spreads via the vagus nerve to the brain. Or giving further evidence to the theory that dysregulated environmental stimuli, such as that received by the vagus nerve from the gut, may have a negative effect on the dopamine reward system of the substantia nigra, thereby causing Parkinsons disease. Chagas disease The neuropathy in Chagas disease spreads in part via the major parasympathetic branches of the vagus nerve. History Etymology The Latin word vagus means literally `` wandering '' ( the words vagrant, vagabond, and vague come from the same root ). Sometimes the right and left branches together are spoken of in the plural and are thus called vagi ( / ˈveɪdʒaɪ / VAY - jy ). The vagus was also historically called the pneumogastric nerve since it innervates both the lungs and the stomach. Additional illustrations Inferior view of the human brain, with the cranial nerves labeled. Section of the neck at about the level of the sixth cervical vertebra Transverse section of thorax, showing relations of pulmonary artery The arch of the aorta, and its branches Dura mater and its processes exposed by removing part of the right half of the skull, and the brain The tracheobronchial lymph glands Section of the medulla oblongata at about the middle of the olive Hind - and mid-brains ; postero - lateral view Upper part of medulla spinalis and hind - and mid-brains ; posterior aspect, exposed in situ The right sympathetic chain and its connections with the thoracic, abdominal, and pelvic plexuses The celiac ganglia with the sympathetic plexuses of the abdominal viscera radiating from the ganglia The position and relation of the esophagus in the cervical region and in the posterior mediastinum, seen from behind The thyroid gland and its relations The thymus of a full - term fetus, exposed in situ Deep dissection of vagus nerve Vagus nerve -- dissection See also This article uses anatomical terminology ; for an overview, see Anatomical terminology. Porphyria -- A rare disorder can cause seizures and damage to the vagal nerve. Vagovagal reflex Inflammatory reflex Vagus ganglion Vagus nerve stimulation Vagusstoff References Jump up ^ Berthoud, H.R. ; Neuhuber, W.L. ( 2000 ). `` Functional and chemical anatomy of the afferent vagal system ''. Autonomic Neuroscience. 85 ( 1 -- 3 ) : 1 -- 17. doi : 10.1016 / S1566 - 0702 ( 00 ) 00215 - 0. PMID 11189015. Jump up ^ Dutschmann, Mathias ; Bautista, Tara G. ; Mörschel, Michael ; Dick, Thomas E. ( 2014 ). `` Learning to breathe : Habituation of Hering -- Breuer inflation reflex emerges with postnatal brainstem maturation ''. Respiratory Physiology & Neurobiology. 195 : 44 -- 49. doi : 10.1016 / j. resp. 2014.02. 009. ISSN 1569 - 9048. PMC 4111629. PMID 24566392. Jump up ^ Eljamel, Sam. Problem Based Neurosurgery. p. 66. doi : 10.1142 / 7830. Jump up ^ Mandal, Ananya ( 25 September 2013 ). `` Vomiting Mechanism ''. News Medical. Archived from the original on 4 January 2015. Retrieved 27 June 2015. Jump up ^ Berthoud HR ( 2008 ). `` The vagus nerve, food intake and obesity ''. Regulatory Peptides. 149 ( 1 -- 3 ) : 15 -- 25. doi : 10.1016 / j. regpep. 2007.08. 024. PMC 2597723. PMID 18482776. Jump up ^ de Lartigue G, Ronveaux CC, Raybould HE ( 2014 ). `` Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity ''. Molecular Metabolism. 3 ( 6 ) : 595 -- 607. doi : 10.1016 / j. molmet. 2014.06. 003. PMC 4142400. PMID 25161883. Jump up ^ `` Peripheral chemoreceptors -- an overview ScienceDirect Topics ''. www.sciencedirect.com. Archived from the original on 3 August 2017. Retrieved 9 February 2018. Jump up ^ `` Exploring the Mind - Body Orgasm ''. Wired. 10 January 2007. Archived from the original on 19 September 2015. Jump up ^ Komisaruk BR, Whipple B, Crawford A, Liu WC, Kalnin A, Mosier K ( 2004 ). `` Brain activation during vaginocervical self - stimulation and orgasm in women with complete spinal cord injury : fMRI evidence of mediation by the vagus nerves ''. Brain Res. 1024 ( 1 -- 2 ) : 77 -- 88. doi : 10.1016 / j. brainres. 2004.07. 029. PMID 15451368. Jump up ^ Pocai, A ; TK Lam ; Gutierrez - Juarez R ( 2005 ). `` Hypothalamic K ( ATP ) channels control hepatic glucose production ''. Nature. 434 ( 7036 ) : 1026 -- 31. doi : 10.1038 / nature03439. PMID 15846348. Jump up ^ Pagotto, U. ( 2009 ). `` Where does insulin resistance start ? The brain ''. Diabetes Care. 32 ( 2 ) : S174 -- 77. doi : 10.2337 / dc09 - S305. Jump up ^ Nemeroff, Charles B. ; et al. ( 2006 ). `` VNS therapy in treatment - resistant depression : clinical evidence and putative neurobiological mechanisms ''. Neuropsychopharmacology. 31 ( 7 ) : 1345 -- 55. doi : 10.1038 / sj. npp. 1301082. PMID 16641939. link Archived 17 October 2006 at the Wayback Machine. Jump up ^ Eisenstein, Michael ( 2013 ). `` Neurodevice startups target peripheral nervous system ''. Nature Biotechnology. 31 ( 10 ) : 865 -- 66. doi : 10.1038 / nbt1013 - 865. PMID 24104737. Jump up ^ `` Feedback on Nexium Side Effects and Usage, page 54 ''. www.askdocweb.com. Archived from the original on 28 December 2017. Retrieved 28 December 2017. Clinical trials are currently underway in Antwerp, Belgium using VNS for the treatment of tonal tinnitus. This came from a breakthrough published in 2011 by researchers at the University of Texas, Dallas. They found that tinnitus could be successfully suppressed in rats when tones were paired with brief pulses of stimulation of the vagus nerve. Jump up ^ `` Archived copy ''. Archived from the original on 24 February 2011. Retrieved 25 March 2011. ^ Jump up to : Vibhuti N, Singh ; Monika Gugneja ( 22 August 2005 ). `` Supraventricular Tachycardia ''. eMedicineHealth.com. Archived from the original on 16 December 2008. Retrieved 28 November 2008. Jump up ^ Mayo Clinic. Device Blocking Stomach Nerve Signals Shows Promise in Obesity Archived 8 March 2009 at the Wayback Machine. Jump up ^ Ulcer surgery may help treat obesity -- Diet and nutrition. MSNBC.com Archived 4 July 2007 at the Wayback Machine. Jump up ^ `` Could nerve - snip spur weight loss ? ''. CNN.com. Turner Broadcasting System. Archived from the original on 2007 - 07 - 13. Jump up ^ The Pernicious Anemia Society Archived 24 July 2010 at the Wayback Machine. Jump up ^ Parkinson 's disease may begin in the gut. Archived 27 June 2015 at the Wayback Machine. Jump up ^ Córdova, E ; et al. ( April 2010 ). `` Neurological manifestations of Chagas ' disease ''. Neurological research. 32 ( 3 ) : 238 -- 44. doi : 10.1179 / 016164110X12644252260637. PMID 20406601. External links Wikimedia Commons has media related to Nervus vagus. MedEd at Loyola grossanatomy / h_n / cn / cn1 / cn10. htm `` 10 - 1 ''. Cranial Nerves. Yale School of Medicine. Archived from the original on 2016 - 03 - 03. figures / chapter_24 / 24 - 7. HTM : Basic Human Anatomy at Dartmouth Medical School cranialnerves at The Anatomy Lesson by Wesley Norman ( Georgetown University ) ( X ) The cranial nerves Terminal Nuclei septal nuclei Course no significant branches Olfactory Nuclei anterior olfactory nucleus Course olfactory bulb olfactory tract Optic Nuclei lateral geniculate nucleus Course optic chiasm optic tract Oculomotor Nuclei oculomotor nucleus Edinger -- Westphal nucleus Branches superior parasympathetic root of ciliary ganglion inferior Trochlear Nucleus Branches no significant branches Trigeminal Nuclei PSN spinal trigeminal nucleus MN TMN Course trigeminal ganglion Branches ophthalmic maxillary mandibular Abducens Nucleus Branches no significant branches Facial Near origin Intermediate nerve Geniculate Inside facial canal Greater petrosal pterygopalatine ganglion Nerve to the stapedius Chorda tympani lingual nerve submandibular ganglion At stylomastoid foramen Posterior auricular Suprahyoid digastric stylohyoid Parotid plexus temporal zygomatic buccal mandibular cervical Nuclei Facial motor nucleus Solitary nucleus Superior salivary nucleus Vestibulocochlear Nuclei vestibular nuclei cochlear nuclei Cochlear nerve striae medullares lateral lemniscus Vestibular Scarpa 's ganglion Glossopharyngeal Before jugular fossa Ganglia superior inferior After jugular fossa Tympanic tympanic plexus lesser petrosal otic ganglion Stylopharyngeal branch Pharyngeal branches Tonsillar branches Lingual branches Carotid sinus Nuclei Nucleus ambiguus Inferior salivatory nucleus Solitary nucleus Vagus Before jugular fossa Ganglia superior inferior After jugular fossa Meningeal branch Auricular branch Neck Pharyngeal branch pharyngeal plexus Superior laryngeal external internal Recurrent laryngeal Superior cervical cardiac Thorax Inferior cardiac Pulmonary Vagal trunks anterior posterior Abdomen Celiac Renal Hepatic Anterior gastric Posterior gastric Nuclei Nucleus ambiguus Dorsal nucleus of vagus nerve Solitary nucleus Accessory Nuclei nucleus ambiguus spinal accessory nucleus Cranial Spinal Hypoglossal Nucleus Branches lingual Retrieved from `` https://en.wikipedia.org/w/index.php?title=Vagus_nerve&oldid=854378920 '' Categories : Vagus nerve Cranial nerves Autonomic nervous system Thorax ( human anatomy ) Abdomen Gustatory system Hidden categories : Pages with unresolved properties Webarchive template wayback links All articles with unsourced statements Articles with unsourced statements from March 2018 Articles with unsourced statements from June 2015 Articles with unsourced statements from August 2017 All articles with vague or ambiguous time Vague or ambiguous time from April 2017 All articles with failed verification Articles with failed verification from April 2017 Use dmy dates from April 2017 Talk Contents About Wikipedia Azərbaycanca Bosanski Català Čeština Deutsch Eesti Español Esperanto Euskara فارسی Français Gaeilge Galego 한국어 Bahasa Indonesia Italiano עברית Қазақша Latina Latviešu Lietuvių Magyar Македонски Nederlands 日本 語 Norsk Polski Português Русский Slovenščina Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska தமிழ் Türkçe Українська 中文 30 more Edit links This page was last edited on 10 August 2018, at 22 : 17 ( UTC ). 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Question: where does the vagus nerve enter the abdomen
Answer: internal jugular vein