Epinephrine - wikipedia Epinephrine This article is about the natural hormone. For the medication, see Epinephrine ( medication ). `` Adrenaline '' and `` Adrenalin '' redirect here. For other uses, see Adrenaline ( disambiguation ). Epinephrine Clinical data Synonyms adrenaline ( BAN UK ) Pharmacokinetic data Metabolism adrenergic synapse ( MAO and COMT ) Onset of action Rapid Biological half - life 2 minutes Duration of action Few minutes Excretion Urine Identifiers IUPAC name ( R ) - 4 - ( 1 - Hydroxy - 2 - ( methylamino ) ethyl ) benzene - 1, 2 - diol CAS Number 51 - 43 - 4 PubChem CID 5816 IUPHAR / BPS 479 DrugBank DB00668 ChemSpider 5611 UNII YKH834O4BH KEGG D00095 ChEBI CHEBI : 28918 ChEMBL CHEMBL679 PDB ligand ALE ( PDBe, RCSB PDB ) ECHA InfoCard 100.000. 090 Chemical and physical data Formula C H NO Molar mass 183.204 g / mol 3D model ( JSmol ) Interactive image Density 1.283 ± 0.06 g / cm @ 20 ° C, 760 Torr SMILES CNC ( C@H ) ( O ) C1 = CC = C ( O ) C ( O ) = C1 InChI InChI = 1S / C9H13NO3 / c1 - 10 - 5 - 9 ( 13 ) 6 - 2 - 3 - 7 ( 11 ) 8 ( 12 ) 4 - 6 / h2 - 4, 9 - 13H, 5H2, 1H3 / t9 - / m0 / s1 Key : UCTWMZQNUQWSLP - VIFPVBQESA - N ( verify ) Epinephrine, also known as adrenalin or adrenaline, is a hormone, neurotransmitter, and medication. Epinephrine is normally produced by both the adrenal glands and certain neurons. It plays an important role in the fight - or - flight response by increasing blood flow to muscles, output of the heart, pupil dilation, and blood sugar. It does this by binding to alpha and beta receptors. It is found in many animals and some single cell organisms. Napoleon Cybulski first isolated epinephrine in 1895. As a medication, it is used to treat a number of conditions including anaphylaxis, cardiac arrest, and superficial bleeding. Inhaled epinephrine may be used to improve the symptoms of croup. It may also be used for asthma when other treatments are not effective. It is given intravenously, by injection into a muscle, by inhalation, or by injection just under the skin. Common side effects include shakiness, anxiety, and sweating. A fast heart rate and high blood pressure may occur. Occasionally it may result in an abnormal heart rhythm. While the safety of its use during pregnancy and breastfeeding is unclear, the benefits to the mother must be taken into account. Contents 1 Physiological effects 1.1 Exercise 1.2 Emotional response 1.3 Memory 2 Pathology 3 Terminology 4 Mechanism of action 5 Measurement in biological fluids 6 Biosynthesis and regulation 6.1 Regulation 7 History 8 Society and culture 8.1 Adrenaline junkie 8.2 Strength 9 References 10 External links Physiological effects The adrenal medulla is a minor contributor to total circulating catecholamines ( L - DOPA is at a higher concentration in the plasma ), though it contributes over 90 % of circulating epinephrine. Little epinephrine is found in other tissues, mostly in scattered chromaffin cells. Following adrenalectomy, epinephrine disappears below the detection limit in the blood stream. The adrenals contribute about 7 % of circulating norepinephrine, most of which is a spill over from neurotransmission with little activity as a hormone. Pharmacological doses of epinephrine stimulate α, α, β, β, and β adrenoceptors of the sympathetic nervous system. Sympathetic nerve receptors are classified as adrenergic, based on their responsiveness to adrenaline. The term `` adrenergic '' is often misinterpreted in that the main sympathetic neurotransmitter is norepinephrine ( noradrenaline ), rather than epinephrine, as discovered by Ulf von Euler in 1946. Epinephrine does have a β adrenoceptor - mediated effect on metabolism and the airway, there being no direct neural connection from the sympathetic ganglia to the airway. The concept of the adrenal medulla and the sympathetic nervous system being involved in the flight, fight and fright response was originally proposed by Cannon. But the adrenal medulla, in contrast to the adrenal cortex, is not required for survival. In adrenalectomized patients hemodynamic and metabolic responses to stimuli such as hypoglycemia and exercise remain normal. Exercise One physiological stimulus to epinephrine secretion is exercise. This was first demonstrated using the denervated pupil of a cat as an assay, later confirmed using a biological assay on urine samples. Biochemical methods for measuring catecholamines in plasma were published from 1950 onwards. Although much valuable work has been published using fluorimetric assays to measure total catecholamine concentrations, the method is too non-specific and insensitive to accurately determine the very small quantities of epinephrine in plasma. The development of extraction methods and enzyme - isotope derivate radio - enzymatic assays ( REA ) transformed the analysis down to a sensitivity of 1 pg for epinephrine. Early REA plasma assays indicated that epinephrine and total catecholamines rise late in exercise, mostly when anaerobic metabolism commences. During exercise the epinephrine blood concentration rises partially from increased secretion from the adrenal medulla and partly from decreased metabolism because of reduced hepatic blood flow. Infusion of epinephrine to reproduce exercise circulating concentrations of epinephrine in subjects at rest has little haemodynamic effect, other than a small β - mediated fall in diastolic blood pressure. Infusion of epinephrine well within the physiological range suppresses human airway hyper - reactivity sufficiently to antagonize the constrictor effects of inhaled histamine. A link between what we now know as the sympathetic system and the lung was shown in 1887 when Grossman showed that stimulation of cardiac accelerator nerves reversed muscarine induced airway constriction. In elegant experiments in the dog, where the sympathetic chain was cut at the level of the diaphragm, Jackson showed that there was no direct sympathetic innervation to the lung, but that bronchoconstriction was reversed by release of epinephrine from the adrenal medulla. An increased incidence of asthma has not been reported for adrenalectomized patients ; those with a predisposition to asthma will have some protection from airway hyper - reactivity from their corticosteroid replacement therapy. Exercise induces progressive airway dilation in normal subjects that correlates with work load and is not prevented by beta blockade. The progressive dilation of the airway with increasing exercise is mediated by a progressive reduction in resting vagal tone. Beta blockade with propranolol causes a rebound in airway resistance after exercise in normal subjects over the same time course as the bronchoconstriction seen with exercise induced asthma. The reduction in airway resistance during exercise reduces the work of breathing. Emotional response Every emotional response has a behavioral component, an autonomic component, and a hormonal component. The hormonal component includes the release of epinephrine, an adrenomedullary response that occurs in response to stress and that is controlled by the sympathetic nervous system. The major emotion studied in relation to epinephrine is fear. In an experiment, subjects who were injected with epinephrine expressed more negative and fewer positive facial expressions to fear films compared to a control group. These subjects also reported a more intense fear from the films and greater mean intensity of negative memories than control subjects. The findings from this study demonstrate that there are learned associations between negative feelings and levels of epinephrine. Overall, the greater amount of epinephrine is positively correlated with an arousal state of negative feelings. These findings can be an effect in part that epinephrine elicits physiological sympathetic responses including an increased heart rate and knee shaking, which can be attributed to the feeling of fear regardless of the actual level of fear elicited from the video. Although studies have found a definite relation between epinephrine and fear, other emotions have not had such results. In the same study, subjects did not express a greater amusement to an amusement film nor greater anger to an anger film. Similar findings were also supported in a study that involved rodent subjects that either were able or unable to produce epinephrine. Findings support the idea that epinephrine does have a role in facilitating the encoding of emotionally arousing events, contributing to higher levels of arousal due to fear. Memory It has been found that adrenergic hormones, such as epinephrine, can produce retrograde enhancement of long - term memory in humans. The release of epinephrine due to emotionally stressful events, which is endogenous epinephrine, can modulate memory consolidation of the events, ensuring memory strength that is proportional to memory importance. Post-learning epinephrine activity also interacts with the degree of arousal associated with the initial coding. There is evidence that suggests epinephrine does have a role in long - term stress adaptation and emotional memory encoding specifically. Epinephrine may also play a role in elevating arousal and fear memory under particular pathological conditions including post-traumatic stress disorder. Overall, `` Extensive evidence indicates that epinephrine ( EPI ) modulates memory consolidation for emotionally arousing tasks in animals and human subjects. '' Studies have also found that recognition memory involving epinephrine depends on a mechanism that depends on β adrenoceptors. Epinephrine does not readily cross the blood -- brain barrier, so its effects on memory consolidation are at least partly initiated by β adrenoceptors in the periphery. Studies have found that sotalol, a β adrenoceptor antagonist that also does not readily enter the brain, blocks the enhancing effects of peripherally administered epinephrine on memory. These findings suggest that β adrenoceptors are necessary for epinephrine to have an effect on memory consolidation. For noradrenaline to be acted upon by PNMT in the cytosol, it must first be shipped out of granules of the chromaffin cells. This may occur via the catecholamine - H exchanger VMAT1. VMAT1 is also responsible for transporting newly synthesized adrenaline from the cytosol back into chromaffin granules in preparation for release. In liver cells, adrenaline binds to the β adrenergic receptor, which changes conformation and helps G, a G protein, exchange GDP to GTP. This trimeric G protein dissociates to G alpha and G beta / gamma subunits. Gs alpha binds to adenyl cyclase, thus converting ATP into cyclic AMP. Cyclic AMP binds to the regulatory subunit of protein kinase A : Protein kinase A phosphorylates phosphorylase kinase. Meanwhile, Gs beta / gamma binds to the calcium channel and allows calcium ions to enter the cytoplasm. Calcium ions bind to calmodulin proteins, a protein present in all eukaryotic cells, which then binds to phosphorylase kinase and finishes its activation. Phosphorylase kinase phosphorylates glycogen phosphorylase, which then phosphorylates glycogen and converts it to glucose - 6 - phosphate. Pathology Increased epinephrine secretion is observed in pheochromocytoma, hypoglycemia, myocardial infarction and to a lesser degree in benign essential familial tremor. A general increase in sympathetic neural activity is usually accompanied by increased adrenaline secretion, but there is selectivity during hypoxia and hypoglycaemia, when the ratio of adrenaline to noradrenaline is considerably increased. Therefore, there must be some autonomy of the adrenal medulla from the rest of the sympathetic system. Myocardial infarction is associated with high levels of circulating epinephrine and norepinephrine, particularly in cardiogenic shock. Benign familial tremor ( BFT ) is responsive to peripheral β adrenergic blockers and β - stimulation is known to cause tremor. Patients with BFT were found to have increased plasma epinephrine, but not norepinephrine. Low, or absent, concentrations of epinephrine can be seen in autonomic neuropathy or following adrenalectomy. Failure of the adrenal cortex, as with Addisons disease, can suppress epinephrine secretion as the activity of the synthesing enzyme, phenylethanolamine - N - methyltransferase, depends on the high concentration of cortisol that drains from the cortex to the medulla. Terminology Epinephrine is the pharmaceutical 's United States Adopted Name and International Nonproprietary Name, though the name adrenaline is frequently used. The term epinephrine was coined by the pharmacologist John Abel ( from the Greek for `` on top of the kidneys '' ), who used the name to describe the extracts he prepared from the adrenal glands as early as 1897. In 1901, Jokichi Takamine patented a purified adrenal extract, and called it `` adrenalin '' ( from the Latin for `` on top of the kidneys '' ), which was trademarked by Parke, Davis & Co in the U.S. In the belief that Abel 's extract was the same as Takamine 's, a belief since disputed, epinephrine became the generic name in the U.S. The British Approved Name and European Pharmacopoeia term for this drug is adrenaline and is indeed now one of the few differences between the INN and BAN systems of names. Among American health professionals and scientists, the term epinephrine is used over adrenaline. However, pharmaceuticals that mimic the effects of epinephrine are often called adrenergics, and receptors for epinephrine are called adrenergic receptors or adrenoceptors. Mechanism of action See also : Adrenergic receptor Physiologic responses to epinephrine by organ Organ Effects Heart Increases heart rate ; contractility ; conduction across AV node Lungs Increases respiratory rate ; bronchodilation Systemic Vasoconstriction and vasodilation Liver Stimulates glycogenolysis Systemic Triggers lipolysis Systemic Muscle contraction Play media 7x speed timelapse video of fish melanophores responding to 200μM adrenaline As a hormone, epinephrine acts on nearly all body tissues. Its actions vary by tissue type and tissue expression of adrenergic receptors. For example, high levels of epinephrine causes smooth muscle relaxation in the airways but causes contraction of the smooth muscle that lines most arterioles. Epinephrine acts by binding to a variety of adrenergic receptors. Epinephrine is a nonselective agonist of all adrenergic receptors, including the major subtypes α, α, β, β, and β. Epinephrine 's binding to these receptors triggers a number of metabolic changes. Binding to α - adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis and inhibits insulin - mediated glycogenesis in muscle. β adrenergic receptor binding triggers glucagon secretion in the pancreas, increased adrenocorticotropic hormone ( ACTH ) secretion by the pituitary gland, and increased lipolysis by adipose tissue. Together, these effects lead to increased blood glucose and fatty acids, providing substrates for energy production within cells throughout the body. Its actions are to increase peripheral resistance via α receptor - dependent vasoconstriction and to increase cardiac output via its binding to β receptors. The goal of reducing peripheral circulation is to increase coronary and cerebral perfusion pressures and therefore increase oxygen exchange at the cellular level. While epinephrine does increase aortic, cerebral, and carotid circulation pressure, it lowers carotid blood flow and end - tidal CO or E CO levels. It appears that epinephrine may be improving macrocirculation at the expense of the capillary beds where actual perfusion is taking place. Measurement in Biological fluids Epinephrine may be quantified in blood, plasma or serum as a diagnostic aid, to monitor therapeutic administration, or to identify the causative agent in a potential poisoning victim. Endogenous plasma epinephrine concentrations in resting adults are normally less than 10 ng / L, but may increase by 10-fold during exercise and by 50-fold or more during times of stress. Pheochromocytoma patients often have plasma adrenaline levels of 1000 -- 10,000 ng / L. Parenteral administration of epinephrine to acute - care cardiac patients can produce plasma concentrations of 10,000 to 100,000 ng / L. Biosynthesis and regulation The biosynthesis of adrenaline involves a series of enzymatic reactions. In chemical terms, epinephrine is one of a group of monoamines called the catecholamines. It is produced in some neurons of the central nervous system, and in the chromaffin cells of the adrenal medulla from the amino acids phenylalanine and tyrosine. Epinephrine is synthesized in the medulla of the adrenal gland in an enzymatic pathway that converts the amino acid tyrosine into a series of intermediates and, ultimately, epinephrine. Tyrosine is first oxidized to L - DOPA, which is subsequently decarboxylated to give dopamine. Oxidation gives norepinephrine. The final step in epinephrine biosynthesis is the methylation of the primary amine of norepinephrine. This reaction is catalyzed by the enzyme phenylethanolamine N - methyltransferase ( PNMT ) which utilizes S - adenosyl methionine ( SAMe ) as the methyl donor. While PNMT is found primarily in the cytosol of the endocrine cells of the adrenal medulla ( also known as chromaffin cells ), it has been detected at low levels in both the heart and brain. Biosynthetic pathways for catecholamines and trace amines in the human brain L - Phenylalanine L - Tyrosine L - DOPA Epinephrine Phenethylamine p - Tyramine Dopamine Norepinephrine N - Methylphenethylamine N - Methyltyramine p - Octopamine Synephrine 3 - Methoxytyramine AADC AADC AADC primary pathway PNMT PNMT PNMT PNMT AAAH AAAH brain CYP2D6 minor pathway COMT DBH DBH Epinephrine is produced in a small group of neurons in the human brain via the metabolic pathway shown above. Regulation The major physiologic triggers of adrenaline release center upon stresses, such as physical threat, excitement, noise, bright lights, and high ambient temperature. All of these stimuli are processed in the central nervous system. Adrenocorticotropic hormone ( ACTH ) and the sympathetic nervous system stimulate the synthesis of adrenaline precursors by enhancing the activity of tyrosine hydroxylase and dopamine β - hydroxylase, two key enzymes involved in catecholamine synthesis. ACTH also stimulates the adrenal cortex to release cortisol, which increases the expression of PNMT in chromaffin cells, enhancing adrenaline synthesis. This is most often done in response to stress. The sympathetic nervous system, acting via splanchnic nerves to the adrenal medulla, stimulates the release of adrenaline. Acetylcholine released by preganglionic sympathetic fibers of these nerves acts on nicotinic acetylcholine receptors, causing cell depolarization and an influx of calcium through voltage - gated calcium channels. Calcium triggers the exocytosis of chromaffin granules and, thus, the release of adrenaline ( and noradrenaline ) into the bloodstream. Unlike many other hormones adrenaline ( as with other catecholamines ) does not exert negative feedback to down - regulate its own synthesis. Abnormally elevated levels of adrenaline can occur in a variety of conditions, such as surreptitious epinephrine administration, pheochromocytoma, and other tumors of the sympathetic ganglia. Its action is terminated with reuptake into nerve terminal endings, some minute dilution, and metabolism by monoamine oxidase and catechol - O - methyl transferase. History Main article : History of catecholamine research Extracts of the adrenal gland were first obtained by Polish physiologist Napoleon Cybulski in 1895. These extracts, which he called nadnerczyna ( `` adrenalin '' ), contained adrenaline and other catecholamines. American ophthalmologist William H. Bates discovered adrenaline 's usage for eye surgeries prior to 20 April 1896. Japanese chemist Jokichi Takamine and his assistant Keizo Uenaka independently discovered adrenaline in 1900. In 1901, Takamine successfully isolated and purified the hormone from the adrenal glands of sheep and oxen. Adrenaline was first synthesized in the laboratory by Friedrich Stolz and Henry Drysdale Dakin, independently, in 1904. Society and culture Adrenaline junkie See also : Novelty seeking An adrenaline junkie is somebody who engages in sensation - seeking behavior through `` the pursuit of novel and intense experiences without regard for physical, social, legal or financial risk ''. Such activities include extreme and risky sports, substance abuse, unsafe sex, and crime. The term relates to the increase in circulating levels of adrenaline during physiological stress. Such an increase in the circulating concentration of adrenaline is secondary to activation of the sympathetic nerves innervating the adrenal medulla, as it is rapid and not present in animals where the adrenal gland has been removed. Although such stress triggers adrenaline release, it also activates many other responses within the central nervous system reward system which drives behavioral responses, so while the circulating adrenaline concentration is present, it may not drive behavior. Nevertheless, adrenaline infusion alone does increase alertness and has roles in the brain including the augmentation of memory consolidation. Strength Main article : Hysterical strength Adrenaline has been implicated in feats of great strength, often occurring in times of crisis. For example, there are stories of a parent lifting part of a car when their child is trapped underneath. References ^ Jump up to : `` Epinephrine ''. The American Society of Health - System Pharmacists. Retrieved Aug 15, 2015. Jump up ^ Nancy caroline 's emergency care in the streets. ( 7th ed. ). ( S.l. ) : Jones And Bartlett Learning. 2012. p. 557. ISBN 9781449645861. ^ Jump up to : Lieberman M, Marks A, Peet A ( 2013 ). Marks ' Basic Medical Biochemistry : A Clinical Approach ( 4th ed. ). Philadelphia : Wolters Kluwer Health / Lippincott Williams & Wilkins. p. 175. ISBN 9781608315727. Jump up ^ `` ( - ) - adrenaline ''. Guide to Pharmacology. IUPS / BPS. Retrieved 21 August 2015. Jump up ^ Bell DR ( 2009 ). Medical physiology : principles for clinical medicine ( 3rd ed. ). Philadelphia : Lippincott Williams & Wilkins. p. 312. ISBN 9780781768528. ^ Jump up to : Khurana ( 2008 ). Essentials of Medical Physiology. Elsevier India. p. 460. ISBN 9788131215661. Jump up ^ Buckley E ( 2013 ). Venomous Animals and Their Venoms : Venomous Vertebrates. Elsevier. p. 478. ISBN 9781483262888. Jump up ^ Animal Physiology : Adaptation and Environment ( 5th ed. ). Cambridge University Press. 1997. p. 510. ISBN 9781107268500. Jump up ^ Szablewski, Leszek ( 2011 ). Glucose Homeostasis and Insulin Resistance. Bentham Science Publishers. p. 68. ISBN 9781608051892. Jump up ^ Everard ML ( February 2009 ). `` Acute bronchiolitis and croup ''. Pediatric Clinics of North America. 56 ( 1 ) : 119 -- 33, x -- xi. PMID 19135584. doi : 10.1016 / j. pcl. 2008.10. 007. Jump up ^ Rizzo V, Memmi M, Moratti R, Melzi d'Eril G, Perucca E ( June 1996 ). `` Concentrations of L - dopa in plasma and plasma ultrafiltrates ''. Journal of Pharmaceutical and Biomedical Analysis. 14 ( 8 -- 10 ) : 1043 -- 6. PMID 8818013. doi : 10.1016 / s0731 - 7085 ( 96 ) 01753 - 0. Jump up ^ Cryer PE ( August 1980 ). `` Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system ''. The New England Journal of Medicine. 303 ( 8 ) : 436 -- 44. PMID 6248784. doi : 10.1056 / nejm198008213030806. Jump up ^ Cryer PE ( November 1976 ). `` Isotope - derivative measurements of plasma norepinephrine and epinephrine in man ''. Diabetes. 25 ( 11 ) : 1071 -- 82. PMID 825406. doi : 10.2337 / diab. 25.11. 1071. Jump up ^ `` Gerich J, et al. Hormonal mechanisms of recovery from insulin - induced hypoglycemia in man ''. Am J Physiol. 236 : 380 -- 385. 1979. Jump up ^ Pacak, Karel ( 2007 ). Catecholamines and adrenergic receptors. In : Pheochromocytoma Diagnosis, Localization, and Treatment. Chapter 6 : Blackwell Publishing Ltd., Oxford. p. 62. Jump up ^ Barger G, Dale HH ( October 1910 ). `` Chemical structure and sympathomimetic action of amines ''. The Journal of Physiology. 41 ( 1 -- 2 ) : 19 -- 59. PMC 1513032. PMID 16993040. doi : 10.1113 / jphysiol. 1910. sp001392. Jump up ^ Von Euler, US ( 1946 ). `` A specific sympathomimetic ergone in adrenergic nerve fibres ( sympathin ) and its relations to adrenaline and nor adrenaline ''. Acta Physiol Scand. 12 : 73 -- 97. doi : 10.1111 / j. 1748 - 1716.1946. tb00368. x. Jump up ^ Von Euler US, Hillarp NA ( January 1956 ). `` Evidence for the presence of noradrenaline in submicroscopic structures of adrenergic axons ''. Nature. 177 ( 4497 ) : 44 -- 5. Bibcode : 1956Natur. 177... 44E. PMID 13288591. doi : 10.1038 / 177044b0. Jump up ^ Warren J ( January 1986 ). `` The adrenal medulla and the airway ''. British Journal of Diseases of the Chest. 80 ( 1 ) : 1 -- 6. PMID 3004549. doi : 10.1016 / 0007 - 0971 ( 86 ) 90002 - 1. Jump up ^ Twentyman OP, Disley A, Gribbin HR, Alberti KG, Tattersfield AE ( October 1981 ). `` Effect of beta - adrenergic blockade on respiratory and metabolic responses to exercise ''. Journal of Applied Physiology. 51 ( 4 ) : 788 -- 93. PMID 6795164. Jump up ^ Richter EA, Galbo H, Christensen NJ ( January 1981 ). `` Control of exercise - induced muscular glycogenolysis by adrenal medullary hormones in rats ''. Journal of Applied Physiology. 50 ( 1 ) : 21 -- 6. PMID 7009527. Jump up ^ Canon, WB. ( 1931 ). `` Studies on the conditions of activity in endocrine organs xxvii. Evidence that medulliadrenal secretion is not continuous ''. Am J Physiol. 98 : 447 -- 453. Jump up ^ Cryer PE, Tse TF, Clutter WE, Shah SD ( August 1984 ). `` Roles of glucagon and epinephrine in hypoglycemic and nonhypoglycemic glucose counterregulation in humans ''. The American Journal of Physiology. 247 ( 2 Pt 1 ) : E198 -- 205. PMID 6147094. Jump up ^ Hoelzer DR, Dalsky GP, Schwartz NS, Clutter WE, Shah SD, Holloszy JO, Cryer PE ( July 1986 ). `` Epinephrine is not critical to prevention of hypoglycemia during exercise in humans ''. The American Journal of Physiology. 251 ( 1 Pt 1 ) : E104 -- 10. PMID 3524257. Jump up ^ Hartman FA, Waite RH, McCordock HA ( 1922 ). `` The liberation of epinephrine during muscular exercise ''. Am J Physiol. 62 : 225 -- 241. Jump up ^ Von Euler US, Hellner S ( September 1952 ). `` Excretion of noradrenaline and adrenaline in muscular work ''. Acta Physiologica Scandinavica. 26 ( 2 -- 3 ) : 183 -- 91. PMID 12985406. doi : 10.1111 / j. 1748 - 1716.1952. tb00900. x. Jump up ^ Lund, A ( 1950 ). `` Simultaneous fluorimetric determinations of adrenaline and noradrenaline in blood ''. Acta Pharmac Tox : 137 -- 146. Jump up ^ Johnson GA, Kupiecki RM, Baker CA ( November 1980 ). `` Single isotope derivative ( radioenzymatic ) methods in the measurement of catecholamines ''. Metabolism. 29 ( 11 Suppl 1 ) : 1106 -- 13. PMID 7001177. doi : 10.1016 / 0026 - 0495 ( 80 ) 90018 - 9. Jump up ^ Galbo H, Holst JJ, Christensen NJ ( January 1975 ). `` Glucagon and plasma catecholamine responses to graded and prolonged exercise in man ''. Journal of Applied Physiology. 38 ( 1 ) : 70 -- 6. PMID 1110246. Jump up ^ Winder WW, Hagberg JM, Hickson RC, Ehsani AA, McLane JA ( September 1978 ). `` Time course of sympathoadrenal adaptation to endurance exercise training in man ''. Journal of Applied Physiology. 45 ( 3 ) : 370 -- 4. PMID 701121. Jump up ^ Kindermann W, Schnabel A, Schmitt WM, Biro G, Hippchen M ( May 1982 ). `` ( Catecholamines, GH, cortisol, glucagon, insulin, and sex hormones in exercise and beta 1 - blockade ( author 's transl ) ) ''. Klinische Wochenschrift. 60 ( 10 ) : 505 -- 12. PMID 6124653. doi : 10.1007 / bf01756096. Jump up ^ Warren JB, Dalton N, Turner C, Clark TJ, Toseland PA ( January 1984 ). `` Adrenaline secretion during exercise ''. Clinical Science. 66 ( 1 ) : 87 -- 90. PMID 6690194. doi : 10.1042 / cs0660087. Jump up ^ Fitzgerald GA, Barnes P, Hamilton CA, Dollery CT ( October 1980 ). `` Circulating adrenaline and blood pressure : the metabolic effects and kinetics of infused adrenaline in man ''. European Journal of Clinical Investigation. 10 ( 5 ) : 401 -- 6. PMID 6777175. doi : 10.1111 / j. 1365 - 2362.1980. tb00052. x. Jump up ^ Warren JB, Dalton N ( May 1983 ). `` A comparison of the bronchodilator and vasopressor effects of exercise levels of adrenaline in man ''. Clinical Science. 64 ( 5 ) : 475 -- 9. PMID 6831836. doi : 10.1042 / cs0640475. Jump up ^ Warren JB, Dalton N, Turner C, Clark TJ ( November 1984 ). `` Protective effect of circulating epinephrine within the physiologic range on the airway response to inhaled histamine in nonasthmatic subjects ''. The Journal of Allergy and Clinical Immunology. 74 ( 5 ) : 683 -- 6. PMID 6389647. doi : 10.1016 / 0091 - 6749 ( 84 ) 90230 - 6. Jump up ^ Grossman M ( 1887 ). `` Das muscarin - lungen - odem ''. Z Klin Med. 12 : 550 -- 591. Jump up ^ Jackson DE ( 1912 ). `` The pulmonary action of the adrenal glands ''. J Pharmac Exp Therap. 4 : 59 -- 74. Jump up ^ Kagawa J, Kerr HD ( February 1970 ). `` Effects of brief graded exercise on specific airway conductance in normal subjects ''. Journal of Applied Physiology. 28 ( 2 ) : 138 -- 44. PMID 5413299. Jump up ^ Warren JB, Jennings SJ, Clark TJ ( January 1984 ). `` Effect of adrenergic and vagal blockade on the normal human airway response to exercise ''. Clinical Science. 66 ( 1 ) : 79 -- 85. PMID 6228370. doi : 10.1042 / cs0660079. Jump up ^ Jennings SJ, Warren JB, Pride NB ( July 1987 ). `` Airway caliber and the work of breathing in humans ''. Journal of Applied Physiology. 63 ( 1 ) : 20 -- 4. PMID 2957350. ^ Jump up to : Mezzacappa E, Katkin E, Palmer S ( 1999 ). `` Epinephrine, arousal, and emotion : A new look at two - factor theory ''. Cognition and Emotion. 13 ( 2 ) : 181 -- 199. doi : 10.1080 / 026999399379320. ^ Jump up to : Toth M, Ziegler M, Sun P, Gresack J, Risbrough V ( February 2013 ). `` Impaired conditioned fear response and startle reactivity in epinephrine - deficient mice ''. Behavioural Pharmacology. 24 ( 1 ) : 1 -- 9. PMC 3558035. PMID 23268986. doi : 10.1097 / FBP. 0b013e32835cf408. Jump up ^ Cahill L, Alkire MT ( March 2003 ). `` Epinephrine enhancement of human memory consolidation : interaction with arousal at encoding ''. Neurobiology of Learning and Memory. 79 ( 2 ) : 194 -- 8. PMID 12591227. doi : 10.1016 / S1074 - 7427 ( 02 ) 00036 - 9. ^ Jump up to : Dornelles A, de Lima MN, Grazziotin M, Presti - Torres J, Garcia VA, Scalco FS, Roesler R, Schröder N ( July 2007 ). `` Adrenergic enhancement of consolidation of object recognition memory ''. Neurobiology of Learning and Memory. 88 ( 1 ) : 137 -- 42. PMID 17368053. doi : 10.1016 / j. nlm. 2007.01. 005. Jump up ^ Roozendaal B, McGaugh JL ( December 2011 ). `` Memory modulation ''. Behavioral Neuroscience. 125 ( 6 ) : 797 -- 824. PMC 3236701. PMID 22122145. doi : 10.1037 / a0026187. Jump up ^ `` SLC18 family of vesicular amine transporters ''. Guide to Pharmacology. IUPHAR / BPS. Retrieved 21 August 2015. Jump up ^ Feldberg W, Minz B, Tsudzimura H ( June 1934 ). `` The mechanism of the nervous discharge of adrenaline ''. The Journal of Physiology. 81 ( 3 ) : 286 -- 304. PMC 1394156. PMID 16994544. doi : 10.1113 / jphysiol. 1934. sp003136. Jump up ^ Burn JH, Hutcheon DE, Parker RH ( September 1950 ). `` Adrenaline and noradrenaline in the suprarenal medulla after insulin ''. British Journal of Pharmacology and Chemotherapy. 5 ( 3 ) : 417 -- 23. PMC 1509946. PMID 14777865. doi : 10.1111 / j. 1476 - 5381.1950. tb00591. x. Jump up ^ Outschoorn AS ( December 1952 ). `` The hormones of the adrenal medulla and their release ''. British Journal of Pharmacology and Chemotherapy. 7 ( 4 ) : 605 -- 15. PMC 1509311. PMID 13019029. doi : 10.1111 / j. 1476 - 5381.1952. tb00728. x. Jump up ^ Benedict CR, Grahame - Smith DG ( August 1979 ). `` Plasma adrenaline and noradrenaline concentrations and dopamine - beta - hydroxylase activity in myocardial infarction with and without cardiogenic shock ''. British Heart Journal. 42 ( 2 ) : 214 -- 20. PMC 482137. PMID 486283. doi : 10.1136 / hrt. 42.2. 214. Jump up ^ Nadeau RA, de Champlain J ( November 1979 ). `` Plasma catecholamines in acute myocardial infarction ''. American Heart Journal. 98 ( 5 ) : 548 -- 54. PMID 495400. doi : 10.1016 / 0002 - 8703 ( 79 ) 90278 - 3. Jump up ^ Larsson S, Svedmyr N ( 1977 ). `` Tremor caused by sympathomimetics is mediated by beta 2 - adrenoceptors ''. Scand J Resp Dis. 58 : 5 -- 10. Jump up ^ Warren JB, O'Brien M, Dalton N, Turner CT ( February 1984 ). `` Sympathetic activity in benign familial tremor ''. Lancet. 1 ( 8374 ) : 461 -- 2. PMID 6142198. doi : 10.1016 / S0140 - 6736 ( 84 ) 91804 - X. Jump up ^ Wurtman RJ, Pohorecky LA, Baliga BS ( June 1972 ). `` Adrenocortical control of the biosynthesis of epinephrine and proteins in the adrenal medulla ''. Pharmacological Reviews. 24 ( 2 ) : 411 -- 26. PMID 4117970. Jump up ^ Wright A, Jones IC ( June 1955 ). `` Chromaffin tissue in the lizard adrenal gland ''. Nature. 175 ( 4466 ) : 1001 -- 2. Bibcode : 1955Natur. 175.1001 W. PMID 14394091. doi : 10.1038 / 1751001b0. Jump up ^ Coupland RE ( April 1953 ). `` On the morphology and adrenaline - nor - adrenaline content of chromaffin tissue ''. The Journal of Endocrinology. 9 ( 2 ) : 194 -- 203. PMID 13052791. doi : 10.1677 / joe. 0.0090194. ^ Jump up to : Aronson JK ( February 2000 ). `` '' Where name and image meet `` -- the argument for `` adrenaline '' ``. BMJ. 320 ( 7233 ) : 506 -- 9. PMC 1127537. PMID 10678871. doi : 10.1136 / bmj. 320.7233. 506. Jump up ^ `` Naming human medicines -- GOV.UK ''. www.mhra.gov.uk. Jump up ^ Shen, Howard ( 2008 ). Illustrated Pharmacology Memory Cards : PharMnemonics. Minireview. p. 4. ISBN 1 - 59541 - 101 - 1. Jump up ^ Arnall DA, Marker JC, Conlee RK, Winder WW ( June 1986 ). `` Effect of infusing epinephrine on liver and muscle glycogenolysis during exercise in rats ''. The American Journal of Physiology. 250 ( 6 Pt 1 ) : E641 -- 9. PMID 3521311. Jump up ^ Raz I, Katz A, Spencer MK ( March 1991 ). `` Epinephrine inhibits insulin - mediated glycogenesis but enhances glycolysis in human skeletal muscle ''. The American Journal of Physiology. 260 ( 3 Pt 1 ) : E430 -- 5. PMID 1900669. ^ Jump up to : Sabyasachi Sircar ( 2007 ). Medical Physiology. Thieme Publishing Group. p. 536. ISBN 3 - 13 - 144061 - 9. Jump up ^ `` Guideline 11.5 : Medications in Adult Cardiac Arrest '' ( PDF ). Australian Resuscitation Council. December 2010. Retrieved 7 March 2015. Jump up ^ Burnett AM, Segal N, Salzman JG, McKnite MS, Frascone RJ ( August 2012 ). `` Potential negative effects of epinephrine on carotid blood flow and ETCO2 during active compression - decompression CPR utilizing an impedance threshold device ''. Resuscitation. 83 ( 8 ) : 1021 -- 4. PMID 22445865. doi : 10.1016 / j. resuscitation. 2012.03. 018. Jump up ^ Raymondos K, Panning B, Leuwer M, Brechelt G, Korte T, Niehaus M, Tebbenjohanns J, Piepenbrock S ( May 2000 ). `` Absorption and hemodynamic effects of airway administration of adrenaline in patients with severe cardiac disease ''. Annals of Internal Medicine. 132 ( 10 ) : 800 -- 3. PMID 10819703. doi : 10.7326 / 0003 - 4819 - 132 - 10 - 200005160 - 00007. Jump up ^ Baselt, R. ( 2008 ). Disposition of Toxic Drugs and Chemicals in Man ( 8th ed. ). Foster City, CA : Biomedical Publications. pp. 545 -- 547. ISBN 0 - 9626523 - 7 - 7. Jump up ^ von Bohlen und Haibach O, Dermietzel R ( 2006 ). Neurotransmitters and Neuromodulators : Handbook of Receptors and Biological Effects. Wiley - VCH. p. 125. ISBN 978 - 3 - 527 - 31307 - 5. Jump up ^ Kirshner N, Goodall M ( June 1957 ). `` The formation of adrenaline from noradrenaline ''. Biochimica et Biophysica Acta. 24 ( 3 ) : 658 -- 9. PMID 13436503. doi : 10.1016 / 0006 - 3002 ( 57 ) 90271 - 8. Jump up ^ Axelrod J ( May 1962 ). `` Purification and Properties of Phenylethanolamine - N - methyl Transferase ''. The Journal of Biological Chemistry. 237 ( 5 ) : 1657 -- 1660. Jump up ^ Broadley KJ ( March 2010 ). `` The vascular effects of trace amines and amphetamines ''. Pharmacol. Ther. 125 ( 3 ) : 363 -- 375. PMID 19948186. doi : 10.1016 / j. pharmthera. 2009.11. 005. Jump up ^ Lindemann L, Hoener MC ( May 2005 ). `` A renaissance in trace amines inspired by a novel GPCR family ''. Trends Pharmacol. Sci. 26 ( 5 ) : 274 -- 281. PMID 15860375. doi : 10.1016 / j. tips. 2005.03. 007. Jump up ^ Wang X, Li J, Dong G, Yue J ( February 2014 ). `` The endogenous substrates of brain CYP2D ''. Eur. J. Pharmacol. 724 : 211 -- 218. PMID 24374199. doi : 10.1016 / j. ejphar. 2013.12. 025. The highest level of brain CYP2D activity was found in the substantia nigra... The in vitro and in vivo studies have shown the contribution of the alternative CYP2D - mediated dopamine synthesis to the concentration of this neurotransmitter although the classic biosynthetic route to dopamine from tyrosine is active... Tyramine levels are especially high in the basal ganglia and limbic system, which are thought to be related to individual behavior and emotion ( Yu et al., 2003c )... Rat CYP2D isoforms ( 2D2 / 2D4 / 2D18 ) are less efficient than human CYP2D6 for the generation of dopamine from p - tyramine. The K values of the CYP2D isoforms are as follows : CYP2D6 ( 87 -- 121 μm ) ≈ CYP2D2 ≈ CYP2D18 > CYP2D4 ( 256 μm ) for m - tyramine and CYP2D4 ( 433 μm ) > CYP2D2 ≈ CYP2D6 > CYP2D18 ( 688 μm ) for p - tyramine Jump up ^ Nelson L, Cox M ( 2004 ). Lehninger Principles of Biochemistry ( 4th ed. ). New York : Freeman. p. 908. ISBN 0 - 7167 - 4339 - 6. Jump up ^ Pharmacology for Anesthetists 5, p52. PediaPress. Jump up ^ `` Adrenaline -- Epinephrine ''. World of Molecules. Retrieved 7 March 2015. Jump up ^ Skalski JH, Kuch J ( April 2006 ). `` Polish thread in the history of circulatory physiology ''. Journal of Physiology and Pharmacology. 57 ( Suppl 1 ) : 5 -- 41. PMID 16766800. Jump up ^ Bates WH ( 16 May 1896 ). `` The Use of Extract of Suprarenal Capsule in the Eye ''. New York Medical Journal. Read before the Section in Ophthalmology of the New York Academy of Medicine, 20 April 1896 : 647 -- 650. Retrieved 7 March 2015. Jump up ^ Yamashima T ( May 2003 ). `` Jokichi Takamine ( 1854 -- 1922 ), the samurai chemist, and his work on adrenalin ''. Journal of Medical Biography. 11 ( 2 ) : 95 -- 102. PMID 12717538. ^ Jump up to : Bennett MR ( June 1999 ). `` One hundred years of adrenaline : the discovery of autoreceptors ''. Clinical Autonomic Research. 9 ( 3 ) : 145 -- 59. PMID 10454061. doi : 10.1007 / BF02281628. Jump up ^ Takamine J ( 1901 ). The isolation of the active principle of the suprarenal gland. The Journal of Physiology. Great Britain : Cambridge University Press. pp. xxix -- xxx. Jump up ^ Zuckerman M ( 2007 ). Sensation seeking and risky behavior ( 2. print. ed. ). Washington, DC : American Psychological Association. ISBN 1591477387. ^ Jump up to : Jänig W ( 2006 ). The integrative action of the autonomic nervous system : neurobiology of homeostasis. Cambridge : UK. pp. 143 -- 146. ISBN 9780521845182. Jump up ^ Deane W, Rubin B ( 1964 ). `` Absence of adrenal meduallary secretions ''. The Adrenocortical Hormones Their Origin -- Chemistry Physiology and Pharmacology. Berlin, Heidelberg : Springer Berlin Heidelberg. p. 105. ISBN 9783662131329. Jump up ^ Frankenhaeuser M, Jarpe G, Matell G ( 1961 ). `` Effects of intravenous infusions of adrenaline and noradrenaline on certain psychological and physiological functions ''. Acta Physiologica Scandinavica. 51 ( 2 -- 3 ) : 175 -- 86. PMID 13701421. doi : 10.1111 / j. 1748 - 1716.1961. tb02126. x. Jump up ^ `` When Fear Makes Us Superhuman ''. Scientific American. 28 Dec 2009. Retrieved 25 August 2015. Jump up ^ Wise J ( 2009 ). Extreme fear : the science of your mind in danger ( 1st ed. ). New York : Palgrave Macmillan. ISBN 0230614396. External links Look up adrenaline junkie in Wiktionary, the free dictionary. U.S. National Library of Medicine : Drug Information Portal -- Epinephrine Hormones Endocrine glands Hypothalamic - pituitary Hypothalamus GnRH TRH Dopamine CRH GHRH Somatostatin ( GHIH ) MCH Posterior pituitary Oxytocin Vasopressin Anterior pituitary FSH LH TSH Prolactin POMC CLIP ACTH MSH Endorphins Lipotropin GH Adrenal axis Adrenal cortex aldosterone cortisol cortisone DHEA DHEA - S androstenedione Adrenal medulla epinephrine norepinephrine Thyroid Thyroid hormone Calcitonin Thyroid axis Parathyroid PTH Gonadal axis Testis testosterone AMH inhibin Ovary estradiol progesterone activin and inhibin relaxin ( pregnancy ) Placenta hCG HPL estrogen progesterone Pancreas glucagon insulin amylin somatostatin pancreatic polypeptide Pineal gland melatonin N, N - dimethyltryptamine 5 - methoxy - N, N - dimethyltryptamine Other Thymus Thymosins Thymosin α1 Beta thymosins Thymopoietin Thymulin Digestive system Stomach gastrin ghrelin Duodenum CCK Incretins GIP GLP - 1 secretin motilin VIP Ileum enteroglucagon peptide YY Liver / other Insulin - like growth factor IGF - 1 IGF - 2 Adipose tissue leptin adiponectin resistin Skeleton Osteocalcin Kidney JGA ( renin ) peritubular cells EPO calcitriol prostaglandin Heart Natriuretic peptide ANP BNP Neurotransmitters Amino acid - derived Major excitatory / inhibitory systems : Glutamate system : Agmatine Aspartic acid ( aspartate ) Cycloserine Glutamic acid ( glutamate ) Glutathione Glycine GSNO GSSG Kynurenic acid NAA NAAG Proline Serine ; GABA system : GABA GABOB GHB ; Glycine system : α - Alanine β - Alanine Glycine Hypotaurine Proline Sarcosine Serine Taurine ; GHB system : GHB T - HCA ( GHC ) Biogenic amines : Monoamines : 6 - OHM Dopamine Epinephrine ( adrenaline ) NAS ( normelatonin ) Norepinephrine ( noradrenaline ) Serotonin ( 5 - HT ) ; Trace amines : 3 - Iodothyronamine N - Methylphenethylamine N - Methyltryptamine m - Octopamine p - Octopamine Phenylethanolamine Phenethylamine Synephrine Tryptamine m - Tyramine p - Tyramine ; Others : Histamine Neuropeptides : See here instead. Lipid - derived Endocannabinoids : 2 - AG 2 - AGE ( noladin ether ) 2 - ALPI 2 - OG AA - 5 - HT Anandamide ( AEA ) DEA LPI NADA NAGly OEA Oleamide PEA RVD - Hpα SEA Virodhamine ( O - AEA ) Neurosteroids : See here instead. Nucleobase - derived Nucleosides : Adenosine system : Adenosine ADP AMP ATP Vitamin - derived Cholinergic system : Acetylcholine Miscellaneous Gasotransmitters : Carbon monoxide ( CO ) Hydrogen sulfide ( H S ) Nitric oxide ( NO ) ; Candidates : Acetaldehyde Ammonia ( NH ) Carbonyl sulfide ( COS ) Nitrous oxide ( N O ) Sulfur dioxide ( SO ) Adrenergic receptor modulators α Agonists : 6 - FNE Amidephrine Anisodine Buspirone Cirazoline Corbadrine Desglymidodrine Dexisometheptene Dipivefrine Dopamine Droxidopa ( L - DOPS ) Ephedrine Epinephrine Etilefrine Etilevodopa Ethylnorepinephrine Indanidine Isometheptene L - DOPA ( levodopa ) L - Phenylalanine L - Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine ( drug ) Oxymetazoline Phenylephrine Phenylpropanolamine Pseudoephedrine Synephrine Tetryzoline Tiamenidine XP21279 Xylometazoline Antagonists : Abanoquil Adimolol Ajmalicine Alfuzosin Amosulalol Anisodamine Arotinolol Atiprosin Atypical antipsychotics ( e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone ) Benoxathian Buflomedil Bunazosin Carvedilol Corynanthine Dapiprazole Domesticine Doxazosin Ergolines ( e.g., ergotamine, dihydroergotamine, lisuride, terguride ) Etoperidone Eugenodilol Fenspiride Hydroxyzine Indoramin Ketanserin L - 765,314 Labetalol mCPP Mepiprazole Metazosin Monatepil Moxisylyte Naftopidil Nantenine Neldazosin Niaprazine Nicergoline Niguldipine Pardoprunox Pelanserin Perlapine Phendioxan Phenoxybenzamine Phentolamine Phenylpiperazine antidepressants ( e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Ritanserin Silodosin Spiperone Talipexole Tamsulosin Terazosin Tiodazosin Tolazoline Tetracyclic antidepressants ( e.g., amoxapine, maprotiline, mianserin ) Tricyclic antidepressants ( e.g., amitriptyline, clomipramine, doxepin, imipramine, trimipramine ) Trimazosin Typical antipsychotics ( e.g., chlorpromazine, fluphenazine, loxapine, thioridazine ) Urapidil WB - 4101 Zolertine α Agonists : ( R ) - 3 - Nitrobiphenyline 4 - NEMD 6 - FNE Amitraz Apraclonidine Brimonidine Cannabivarin Clonidine Corbadrine Detomidine Dexmedetomidine Dihydroergotamine Dipivefrine Dopamine Droxidopa ( L - DOPS ) Etilevodopa Ephedrine Ergotamine Epinephrine Etilefrine Ethylnorepinephrine Guanabenz Guanfacine Guanoxabenz L - DOPA ( levodopa ) L - Phenylalanine L - Tyrosine Lofexidine Medetomidine Melevodopa Methyldopa Mivazerol Naphazoline Norepinephrine Oxymetazoline Phenylpropanolamine Piperoxan Pseudoephedrine Rezatomidine Rilmenidine Romifidine Talipexole Tasipimidine Tetrahydrozoline Tiamenidine Tizanidine Tolonidine Urapidil Vatinoxan XP21279 Xylazine Xylometazoline Antagonists : 1 - PP Adimolol Amesergide Aptazapine Atipamezole Atypical antipsychotics ( e.g., asenapine, brexpiprazole, clozapine, lurasidone, paliperidone, quetiapine, risperidone, zotepine ) Azapirones ( e.g., buspirone, gepirone, ipsapirone, tandospirone ) BRL - 44408 Buflomedil Cirazoline Efaroxan Esmirtazapine Fenmetozole Fluparoxan Idazoxan mCPP Mianserin Mirtazapine NAN - 190 Olanzapine Pardoprunox Phentolamine Phenoxybenzamine Piperoxan Piribedil Rauwolscine Rotigotine SB - 269970 Setiptiline Spiroxatrine Sunepitron Tolazoline Typical antipsychotics ( e.g., chlorpromazine, fluphenazine, loxapine, thioridazine ) Yohimbine β Agonists : Abediterol Alifedrine Amibegron Arbutamine Arformoterol Arotinolol BAAM Bambuterol Befunolol Bitolterol Broxaterol Buphenine Carbuterol Carmoterol Cimaterol Clenbuterol Colterol Corbadrine Denopamine Dipivefrine Dobutamine Dopamine Dopexamine Droxidopa ( L - DOPS ) Ephedrine Epinephrine Etafedrine Etilefrine Etilevodopa Ethylnorepinephrine Fenoterol Formoterol Hexoprenaline Higenamine Indacaterol Isoetarine Isoprenaline Isoxsuprine L - DOPA ( levodopa ) L - Phenylalanine L - Tyrosine Levosalbutamol Mabuterol Melevodopa Methoxyphenamine Methyldopa Mirabegron Norepinephrine Orciprenaline Oxyfedrine PF - 610355 Phenylpropanolamine Pirbuterol Prenalterol Ractopamine Procaterol Pseudoephedrine Reproterol Rimiterol Ritodrine Salbutamol Salmeterol Solabegron Terbutaline Tretoquinol Tulobuterol Vilanterol Xamoterol XP21279 Zilpaterol Zinterol Antagonists : Acebutolol Adaprolol Adimolol Afurolol Alprenolol Alprenoxime Amosulalol Ancarolol Arnolol Arotinolol Atenolol Befunolol Betaxolol Bevantolol Bisoprolol Bopindolol Bornaprolol Brefonalol Bucindolol Bucumolol Bufetolol Bufuralol Bunitrolol Bunolol Bupranolol Butaxamine Butidrine Butofilolol Capsinolol Carazolol Carpindolol Carteolol Carvedilol Celiprolol Cetamolol Cicloprolol Cinamolol Cloranolol Cyanopindolol Dalbraminol Dexpropranolol Diacetolol Dichloroisoprenaline Dihydroalprenolol Dilevalol Diprafenone Draquinolol Ecastolol Epanolol Ericolol Ersentilide Esatenolol Esprolol Eugenodilol Exaprolol Falintolol Flestolol Flusoxolol Hydroxycarteolol Hydroxytertatolol ICI - 118,551 Idropranolol Indenolol Indopanolol Iodocyanopindolol Iprocrolol Isoxaprolol Isamoltane Labetalol Landiolol Levobetaxolol Levobunolol Levomoprolol Medroxalol Mepindolol Metipranolol Metoprolol Moprolol Nadolol Nadoxolol Nebivolol Nifenalol Nipradilol Oxprenolol Pacrinolol Pafenolol Pamatolol Pargolol Penbutolol Pindolol Practolol Primidolol Procinolol Pronethalol Propafenone Propranolol Ridazolol Ronactolol Soquinolol Sotalol Spirendolol SR 59230A Sulfinalol Talinolol Tazolol Tertatolol Tienoxolol Tilisolol Timolol Tiprenolol Tolamolol Toliprolol Xibenolol Xipranolol See also : Receptor / signaling modulators Dopaminergics Serotonergics Monoamine reuptake inhibitors Monoamine releasing agents Monoamine metabolism modulators Monoamine neurotoxins Phenethylamines Phenethylamines Psychedelics : 25B - NBOMe 25C - NBOMe 25D - NBOMe 25I - NBOMe 25N - NBOMe 2C - B 2C - B - AN 2C - Bn 2C - Bu 2C - C 2C - CN 2C - CP 2C - D 2C - E 2C - EF 2C - F 2C - G 2C - G - 1 2C - G - 2 2C - G - 3 2C - G - 4 2C - G - 5 2C - G - 6 2C - G-N 2C - H 2C - I 2C - iP 2C - N 2C - NH2 2C - O 2C - O - 4 2C - P 2C - Ph 2C - SE 2C - T 2C - T - 2 2C - T - 3 2C - T - 4 2C - T - 5 2C - T - 6 2C - T - 7 2C - T - 8 2C - T - 9 2C - T - 10 2C - T - 11 2C - T - 12 2C - T - 13 2C - T - 14 2C - T - 15 2C - T - 16 2C - T - 17 2C - T - 18 2C - T - 19 2C - T - 20 2C - T - 21 2C - T - 22 2C - T - 22.5 2C - T - 23 2C - T - 24 2C - T - 25 2C - T - 27 2C - T - 28 2C - T - 30 2C - T - 31 2C - T - 32 2C - T - 33 2C - TFE 2C - TFM 2C - YN 2C - V Allylescaline DESOXY Escaline Isoproscaline Jimscaline Macromerine MEPEA Mescaline Metaescaline Methallylescaline Proscaline Psi - 2C - T - 4 TCB - 2 Stimulants : Phenylethanolamine Hordenine Phenethylamine α - Methylphenethylamine ( amphetamine ) β - Methylphenethylamine m - Methylphenethylamine N - Methylphenethylamine o - Methylphenethylamine p - Methylphenethylamine Entactogens : Lophophine MDPEA MDMPEA Others : BOH DMPEA Amphetamines Psychedelics : 3C - BZ 3C - E 3C - P Aleph Beatrice Bromo - DragonFLY D - Deprenyl DMA DMCPA DMMDA DOB DOC DOEF DOET DOI DOM DON DOPR DOTFM Ganesha MMDA MMDA - 2 Psi - DOM TMA TeMA Stimulants : 2 - FA 2 - FMA 3 - FA 3 - FMA Acridorex Alfetamine Amfecloral Amfepentorex Amphetamine ( Dextroamphetamine, Levoamphetamine ) Amphetaminil Benfluorex Benzphetamine Cathine Clobenzorex Dimethylamphetamine Ephedrine Etilamfetamine Fencamfamin Fencamine Fenethylline Fenfluramine ( Dexfenfluramine, Levofenfluramine ) Fenproporex Flucetorex Fludorex Formetorex Furfenorex Gepefrine 4 - Hydroxyamphetamine Iofetamine Isopropylamphetamine Lefetamine Lisdexamfetamine Mefenorex Metaraminol Methamphetamine ( Dextromethamphetamine, Levomethamphetamine ) Methoxyphenamine MMA Morforex Norfenfluramine L - Norpseudoephedrine N, alpha - Diethylphenylethylamine Oxifentorex Oxilofrine Ortetamine PBA PCA Phenpromethamine PFA PFMA PIA PMA PMEA PMMA Phenylpropanolamine Pholedrine Prenylamine Propylamphetamine Pseudoephedrine Sibutramine Tiflorex Tranylcypromine Xylopropamine Zylofuramine Entactogens : 4 - FA 4 - FMA 4 - MA 4 - MMA 4 - MTA 5 - APB 5 - APDB 5 - EAPB 5 - IT 5 - MAPB 5 - MAPDB 6 - APB 6 - APDB 6 - Chloro - MDMA 6 - EAPB 6 - IT 6 - MAPB 6 - MAPDB EDA IAP 2, 3 - MDA 3, 4 - MDA ( tenamfetamine ) MDEA MDHMA MDMA ( midomafetamine ) MDOH Methamnetamine MMDMA Naphthylaminopropane TAP Others : 3, 4 - DCA Amiflamine DiFMDA Selegiline ( also D - Deprenyl ) Phentermines Stimulants : Chlorphentermine Cloforex Clortermine Etolorex Mephentermine Pentorex Phentermine Entactogens : MDPH MDMPH Others : Cericlamine Cathinones Stimulants : 3 - FMC 4 - MC 4 - BMC 4 - CMC 4 - EMC 4 - FMC 4 - MEC 4 - MeMABP 4 - MPD Amfepramone Benzedrone Brephedrone Buphedrone Bupropion Cathinone Dimethylcathinone Ethcathinone Eutylone Hydroxybupropion Methcathinone Methedrone NEB Pentedrone Pentylone Radafaxine Entactogens : 3, 4 - DMMC 3 - MMC Butylone Ethylone Methylone Methylenedioxycathinone Mephedrone Phenylisobutylamines Entactogens : 4 - CAB 4 - MAB Ariadne BDB Butylone EBDB Eutylone MBDB Stimulants : Phenylisobutylamine Phenylalkylpyrrolidines Stimulants : α - PBP α - PHP α - PPP α - PVP MDPBP MDPPP MDPV 4 - MePBP 4 - MePHP 4 - MePPP MOPPP MOPVP MPBP MPHP MPPP Naphyrone PEP Prolintane Pyrovalerone Catecholamines ( and close relatives ) 6 - FNE 6 - OHDA a-Me - DA a-Me - TRA Adrenochrome Ciladopa D - DOPA ( Dextrodopa ) Dimetofrine Dopamine Epinephrine Epinine Etilefrine Ethylnorepinephrine Fenclonine Ibopamine Isoprenaline Isoetarine L - DOPA ( Levodopa ) L - DOPS ( Droxidopa ) L - Phenylalanine L - Tyrosine m - Tyramine Metanephrine Metaraminol Metaterol Metirosine Methyldopa N, N - Dimethyldopamine Nordefrin ( Levonordefrin ) Norepinephrine Norfenefrine ( m - Octopamine ) Normetanephrine Orciprenaline p - Octopamine p - Tyramine Phenylephrine Synephrine Miscellaneous AL - LAD Amidephrine Arbutamine Cafedrine Denopamine Desvenlafaxine Diphenidine Dizocilpine Dobutamine Dopexamine Ephenidine Etafedrine ETH - LAD Famprofazone Fluorolintane Hexapradol IP - LAD Lysergic acid amide Lysergic acid 2 - butyl amide Lysergic acid 2, 4 - dimethylazetidide Lysergic acid diethylamide Methoxamine Methoxphenidine MT - 45 PARGY - LAD Phenibut PRO-LAD Pronethalol Salbutamol ( Levosalbutamol ) Solriamfetol Theodrenaline Thiamphenicol UWA - 101 LCCN : sh85001007 GND : 4141449 - 4 NDL : 00560062 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Epinephrine&oldid=807291216 '' Categories : Anxiety Beta - adrenergic agonists Bronchodilators Cardiac stimulants Catecholamines Hormones of the hypothalamus - pituitary - adrenal axis Hormones of the suprarenal medulla Neurotransmitters Norepinephrine releasing agents Stress Sympathomimetic amines Chemical substances for emergency medicine Hidden categories : Use dmy dates from October 2016 Infobox drug with local INN variant ECHA InfoCard ID from Wikidata Drugs missing an ATC code Drugs with no legal status Drugboxes which contain changes to watched fields All articles with unsourced statements Articles with unsourced statements from April 2009 All articles with vague or ambiguous time Vague or ambiguous time from February 2017 Wikipedia articles with LCCN identifiers Wikipedia articles with GND identifiers Articles containing video clips Talk Contents About Wikipedia Afrikaans Azərbaycanca বাংলা Беларуская Български Bosanski Català Čeština Dansk Deutsch ދިވެހިބަސް Eesti Ελληνικά Español Esperanto Euskara فارسی Français Gaeilge Galego 한국어 Հայերեն Hrvatski Ido Bahasa Indonesia Italiano עברית Қазақша Kurdî Кыргызча Latina Latviešu Lietuvių Magyar Македонски മലയാളം Bahasa Melayu Nederlands 日本 語 Norsk Norsk nynorsk Occitan ଓଡ଼ିଆ Oʻzbekcha / ўзбекча Polski Português Română Русский Scots Shqip Simple English Slovenčina Slovenščina کوردی Српски / srpski Srpskohrvatski / српскохрватски Basa Sunda Suomi Svenska Tagalog தமிழ் ไทย Тоҷикӣ Türkçe Українська Tiếng Việt 中文 Edit links This page was last edited on 27 October 2017, at 02 : 08. 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Question: epinephrine is a member of which group of hormones
Answer: adrenal glands