Bone marrow - wikipedia Bone marrow For the use of animal bone marrow as human food, see Bone marrow ( food ). Bone marrow A simplified illustration of cells in bone marrow Details System Immune system ( Lymphatic system ) ( Endocrine system ) Identifiers Latin Medulla ossium MeSH D001853 TA A13. 1.01. 001 FMA 9608 Anatomical terminology ( edit on Wikidata ) Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production or hematopoiesis. It is composed of hematopoietic cells, marrow adipose tissue, and supportive stromal cells. On average, bone marrow constitutes 4 % of the total body mass of humans ; in an adult having 65 kilograms of mass ( 143 lb ), bone marrow typically accounts for approximately 2.6 kilograms ( 5.7 lb ). Human marrow produces approximately 500 billion blood cells per day, which join the systemic circulation via permeable vasculature sinusoids within the medullary cavity. All types of hematopoietic cells, including both myeloid and lymphoid lineages, are created in bone marrow ; however, lymphoid cells must migrate to other lymphoid organs ( e.g. thymus ) in order to complete maturation. Bone marrow transplants can be conducted to treat severe diseases of the bone marrow, including certain forms of cancer such as leukemia. Additionally, bone marrow stem cells have been successfully transformed into functional neural cells, and can also potentially be used to treat illnesses such as inflammatory bowel disease. Contents 1 Structure 1.1 Hematopoietic components 1.2 Stroma 2 Function 2.1 Mesenchymal stem cells 2.2 Bone marrow barrier 2.3 Lymphatic role 2.4 Compartmentalization 3 Society and culture 4 Clinical significance 4.1 Disease 4.2 Imaging 4.3 Histology 4.4 Donation and transplantation 4.4. 1 Harvesting 5 Fossil record 6 See also 7 References 8 External links 9 Further reading Structure The composition of marrow is dynamic, as the mixture of cellular and non-cellular components ( connective tissue ) shifts with age and in response to systemic factors. In humans, marrow is colloquially characterized as `` red '' or `` yellow '' marrow ( Latin : medulla ossium rubra, Latin : medulla ossium flava, respectively ) depending on the prevalence of hematopoetic cells vs fat cells. While the precise mechanisms underlying marrow regulation are not understood, compositional changes occur according to stereotypical patterns. For example, a newborn baby 's bones exclusively contain hematopoietically active `` red '' marrow, and there is a progressive conversion towards `` yellow '' marrow with age. In adults, red marrow is found mainly in the central skeleton, such as the pelvis, sternum, cranium, ribs, vertebrae and scapulae, and variably found in the proximal epiphyseal ends of long bones such as the femur and humerus. In circumstances of chronic hypoxia, the body can convert yellow marrow back to red marrow to increase blood cell production. Hematopoietic components Hematopoietic precursor cells : promyelocyte in the center, two metamyelocytes next to it and band cells from a bone marrow aspirate. At the cellular level, the main functional component of bone marrow includes the progenitor cells which are destined to mature into blood and lymphoid cells. Marrow contains hematopoietic stem cells which give rise to the three classes of blood cells that are found in circulation : white blood cells ( leukocytes ), red blood cells ( erythrocytes ), and platelets ( thrombocytes ). Cellular constitution of the red bone marrow parenchyma Group Cell type Average fraction Reference range Myelopoietic cells Myeloblasts 0.9 % 0.2 -- 1.5 Promyelocytes 3.3 % 2.1 -- 4.1 Neutrophilic myelocytes 12.7 % 8.2 -- 15.7 Eosinophilic myelocytes 0.8 % 0.2 -- 1.3 Neutrophilic metamyelocytes 15.9 % 9.6 -- 24.6 Eosinophilic metamyelocytes 1.2 % 0.4 -- 2.2 Neutrophilic band cells 12.4 % 9.5 -- 15.3 Eosinophilic band cells 0.9 % 0.2 -- 2.4 Segmented neutrophils 7.4 % 6.0 -- 12.0 Segmented eosinophils 0.5 % 0.0 -- 1.3 Segmented basophils and mast cells 0.1 % 0.0 -- 0.2 Erythropoietic cells Pronormoblasts 0.6 % 0.2 -- 1.3 Basophilic normoblasts 1.4 % 0.5 -- 2.4 Polychromatic normoblasts 21.6 % 17.9 -- 29.2 Orthochromatic normoblast 2.0 % 0.4 -- 4.6 Other cell types Megakaryocytes < 0.1 % 0.0 - 0.4 Plasma cells 1.3 % 0.4 - 3.9 Reticular cells 0.3 % 0.0 - 0.9 Lymphocytes 16.2 % 11.1 - 23.2 Monocytes 0.3 % 0.0 - 0.8 Stroma The stroma of the bone marrow includes all tissue not directly involved in the marrow 's primary function of hematopoiesis. Stromal cells may be indirectly involved in hematopoiesis, providing a microenvironment that influences the function and differentiation of hematopoeietic cells. For instance, they generate colony stimulating factors, which have a significant effect on hematopoiesis. Cell types that constitute the bone marrow stroma include : fibroblasts ( reticular connective tissue ) macrophages, which contribute especially to red blood cell production, as they deliver iron for hemoglobin production. adipocytes ( fat cells ) osteoblasts ( synthesize bone ) osteoclasts ( resorb bone ) endothelial cells, which form the sinusoids. These derive from endothelial stem cells, which are also present in the bone marrow. Function Mesenchymal stem cells Main article : Mesenchymal stem cell The bone marrow stroma contains mesenchymal stem cells ( MSCs ), also known as marrow stromal cells. These are multipotent stem cells that can differentiate into a variety of cell types. MSCs have been shown to differentiate, in vitro or in vivo, into osteoblasts, chondrocytes, myocytes, marrow adipocytes and beta - pancreatic islets cells. Bone marrow barrier The blood vessels of the bone marrow constitute a barrier, inhibiting immature blood cells from leaving the marrow. Only mature blood cells contain the membrane proteins, such as aquaporin and glycophorin, that are required to attach to and pass the blood vessel endothelium. Hematopoietic stem cells may also cross the bone marrow barrier, and may thus be harvested from blood. Lymphatic role The red bone marrow is a key element of the lymphatic system, being one of the primary lymphoid organs that generate lymphocytes from immature hematopoietic progenitor cells. The bone marrow and thymus constitute the primary lymphoid tissues involved in the production and early selection of lymphocytes. Furthermore, bone marrow performs a valve - like function to prevent the backflow of lymphatic fluid in the lymphatic system. Compartmentalization Biological compartmentalization is evident within the bone marrow, in that certain cell types tend to aggregate in specific areas. For instance, erythrocytes, macrophages, and their precursors tend to gather around blood vessels, while granulocytes gather at the borders of the bone marrow. Society and culture Animal bone marrow has been used in cuisine worldwide for millennia, such as the famed Milanese Ossobuco. Clinical significance Disease The normal bone marrow architecture can be damaged or displaced by aplastic anemia, malignancies such as multiple myeloma, or infections such as tuberculosis, leading to a decrease in the production of blood cells and blood platelets. The bone marrow can also be affected by various forms of leukemia, which attacks its hematologic progenitor cells. Furthermore, exposure to radiation or chemotherapy will kill many of the rapidly dividing cells of the bone marrow, and will therefore result in a depressed immune system. Many of the symptoms of radiation poisoning are due to damage sustained by the bone marrow cells. To diagnose diseases involving the bone marrow, a bone marrow aspiration is sometimes performed. This typically involves using a hollow needle to acquire a sample of red bone marrow from the crest of the ilium under general or local anesthesia. Imaging Medical imaging may provide a limited amount of information regarding bone marrow. Plain film x-rays pass through soft tissues such as marrow and do not provide visualization, although any changes in the structure of the associated bone may be detected. CT imaging has somewhat better capacity for assessing the marrow cavity of bones, although with low sensitivity and specificity. For example, normal fatty `` yellow '' marrow in adult long bones is of low density ( - 30 to - 100 Hounsfield units ), between subcutaneous fat and soft tissue. Tissue with increased cellular composition, such as normal `` red '' marrow or cancer cells within the medullary cavity will measure variably higher in density. MRI is more sensitive and specific for assessing bone bone composition. MRI enables assessment of the average molecular composition of soft tissues, and thus provides information regarding the relative fat content of marrow. In adult humans, `` yellow '' fatty marrow is the dominant tissue in bones, particularly in the ( peripheral ) appendicular skeleton. Because fat molecules have a high T1 - relaxivity, T1 - weighted imaging sequences show `` yellow '' fatty marrow as bright ( hyperintense ). Furthermore, normal fatty marrow loses signal on fat - saturation sequences, in a similar pattern to subcutaneous fat. When `` yellow '' fatty marrow becomes replaced by tissue with more cellular composition, this change is apparent as decreased brightness on T1 - weighted sequences. Both normal `` red '' marrow and pathologic marrow lesions ( such as cancer ) are darker than `` yellow '' marrow on T1 - weight sequences, although can often be distinguished by comparison with the MR signal intensity of adjacent soft tissues. Normal `` red '' marrow is typically equivalent or brighter than skeletal muscle or intervertebral disc on T1 - weighted sequences. Fatty marrow change, the inverse of red marrow hyperplasia, can occur with normal aging, though it can also be seen with certain treatments such as radiation therapy. Diffuse marrow T1 hypointensity without contrast enhancement or cortical discontinuity suggests red marrow conversion or myelofibrosis. Falsely normal marrow on T1 can be seen with diffuse multiple myeloma or leukemic infiltration when the water to fat ratio is not sufficiently altered, as may be seen with lower grade tumors or earlier in the disease process. Histology Main article : Bone marrow examination A Wright 's - stained bone marrow aspirate smear from a patient with leukemia. Bone marrow examination is the pathologic analysis of samples of bone marrow obtained via biopsy and bone marrow aspiration. Bone marrow examination is used in the diagnosis of a number of conditions, including leukemia, multiple myeloma, anemia, and pancytopenia. The bone marrow produces the cellular elements of the blood, including platelets, red blood cells and white blood cells. While much information can be gleaned by testing the blood itself ( drawn from a vein by phlebotomy ), it is sometimes necessary to examine the source of the blood cells in the bone marrow to obtain more information on hematopoiesis ; this is the role of bone marrow aspiration and biopsy. The ratio between myeloid series and erythroid cells is relevant to bone marrow function, and also to diseases of the bone marrow and peripheral blood, such as leukemia and anemia. The normal myeloid - to - erythroid ratio is around 3 : 1 ; this ratio may increase in myelogenous leukemias, decrease in polycythemias, and reverse in cases of thalassemia. Donation and transplantation Main article : Hematopoietic stem cell transplantation A bone marrow harvest in progress. The preferred sites for the procedure In a bone marrow transplant, hematopoietic stem cells are removed from a person and infused into another person ( allogenic ) or into the same person at a later time ( autologous ). If the donor and recipient are compatible, these infused cells will then travel to the bone marrow and initiate blood cell production. Transplantation from one person to another is conducted for the treatment of severe bone marrow diseases, such as congenital defects, autoimmune diseases or malignancies. The patient 's own marrow is first killed off with drugs or radiation, and then the new stem cells are introduced. Before radiation therapy or chemotherapy in cases of cancer, some of the patient 's hematopoietic stem cells are sometimes harvested and later infused back when the therapy is finished to restore the immune system. Bone marrow stem cells can be induced to become neural cells to treat neurological illnesses, and can also potentially be used for the treatment of other illnesses, such as inflammatory bowel disease. In 2013, following a clinical trial, scientists proposed that bone marrow transplantation could be used to treat HIV in conjunction with antiretroviral drugs ; however, it was later found that HIV remained in the bodies of the test subjects. Harvesting The stem cells are typically harvested directly from the red marrow in the iliac crest, often under general anesthesia. The procedure is minimally invasive and does not require stitches afterwards. Depending on the donor 's health and reaction to the procedure, the actual harvesting can be an outpatient procedure, or can require 1 -- 2 days of recovery in the hospital. Another option is to administer certain drugs that stimulate the release of stem cells from the bone marrow into circulating blood. An intravenous catheter is inserted into the donor 's arm, and the stem cells are then filtered out of the blood. This procedure is similar to that used in blood or platelet donation. In adults, bone marrow may also be taken from the sternum, while the tibia is often used when taking samples from infants. In newborns, stem cells may be retrieved from the umbilical cord. Fossil record Bone marrow may have first evolved in Eusthenopteron, a species of prehistoric fish with close links to early tetrapods. The earliest fossilised evidence of bone marrow was discovered in 2014 in Eusthenopteron, a lobe - finned fish which lived during the Devonian period approximately 370 million years ago. Scientists from Uppsala University and the European Synchrotron Radiation Facility used X-ray synchrotron microtomography to study the fossilised interior of the skeleton 's humerus, finding organised tubular structures akin to modern vertebrate bone marrow. Eusthenopteron is closely related to the early tetrapods, which ultimately evolved into the land - dwelling mammals and lizards of the present day. See also National Marrow Donor Program, a nonprofit organization that operates a registry of volunteer hematopoietic cell donors and umbilical cord blood units in the United States Gift of Life Marrow Registry, an American bone marrow transplantation registry References Jump up ^ Schmidt, Richard F. ; Lang, Florian ; Heckmann, Manfred ( 2010 - 11 - 30 ). `` What are the organs of the immune system ? ''. © IQWiG ( Institute for Quality and Efficiency in Health Care ) : 3 / 7. Jump up ^ C., Farhi, Diane ( 2009 ). Pathology of bone marrow and blood cells ( 2nd ed. ). Philadelphia : Wolters Kluwer Health / Lippincott William & Wilkins. ISBN 9780781770934. OCLC 191807944. Jump up ^ Arikan, Hüseyin ; Çiçek, Kerim ( 2014 ). `` Haematology of amphibians and reptiles : a review '' ( PDF ). NORTH - WESTERN JOURNAL OF ZOOLOGY. 10 : 190 -- 209. Jump up ^ Vunjak - Novakovic, G. ; Tandon, N. ; Godier, A. ; Maidhof, R. ; Marsano, A. ; Martens, T.P. ; Radisic, M. 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Jump up ^ McGuckin, C.P. ; Forraz, N. ; Baradez, M. - O. ; Navran, S. ; Zhao, J. ; Urban, R. ; Tilton, R. ; Denner, L. ( 2005 ). `` Production of stem cells with embryonic characteristics from human umbilical cord blood ''. Cell Proliferation. 38 ( 4 ) : 245 -- 255. doi : 10.1111 / j. 1365 - 2184.2005. 00346. x. PMID 16098183. ^ Jump up to : Sanchez, S. ; Tafforeau, P. ; Ahlberg, P.E. ( 2014 ). `` The humerus of Eusthenopteron : a puzzling organization presaging the establishment of tetrapod limb bone marrow ''. Proceedings of the Royal Society B : Biological Sciences. 281 ( 1782 ) : 20140299. doi : 10.1098 / rspb. 2014.0299. External links Bone marrow histology photomicrographs Further reading Wikimedia Commons has media related to Bone marrow. Nature Bone Marrow Transplantation ( Nature Publishing Group ) -- specialist scientific journal with articles on bone marrow biology and clinical uses. Cooper, B ( 2011 ). `` The origins of bone marrow as the seedbed of our blood : from antiquity to the time of Osler '' ( PDF ). Baylor University Medical Center Proceedings. 24 ( 2 ) : 115 -- 8. PMC 3069519. PMID 21566758. Wang J, Yu L, Jiang C, Chen M, Ou C, Wang J ( 2013 ). `` Bone marrow mononuclear cells exert long - term neuroprotection in a rat model of ischemic stroke by promoting arteriogenesis and angiogenesis ''. Brain Behav Immun. 34 : 56 -- 66. doi : 10.1016 / j. bbi. 2013.07. 010. PMC 3795857. PMID 23891963. Wang J, Yu L, Jiang C, Fu X, Liu X, Wang M, Ou C, Cui X, Zhou C, Wang J ( 2015 ). `` Cerebral ischemia increases bone marrow CD4 + CD25 + FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system ''. Brain Behav Immun. 43 : 172 -- 83. doi : 10.1016 / j. bbi. 2014.07. 022. PMC 4258426. PMID 25110149. Wang J, Liu X, Lu H, Jiang C, Cui X, Yu L, Fu X, Li Q, Wang J ( 2015 ). `` CXCR4 ( + ) CD45 ( - ) BMMNC subpopulation is superior to unfractionated BMMNCs for protection after ischemic stroke in mice ''. Brain Behav Immun. 45 : 98 -- 108. doi : 10.1016 / j. bbi. 2014.12. 015. PMC 4342301. PMID 25526817. Organs of the lymphatic system Primary organs Bone marrow Hematopoietic stem cell Thymus Hassall 's corpuscles Secondary organs Spleen Structure Hilum Trabeculae Red pulp Cords of Billroth Marginal zone White pulp Periarteriolar lymphoid sheaths Germinal center Blood flow Trabecular arteries Trabecular veins Tonsils Palatine Lingual Pharyngeal Tubal Tonsillar crypts Waldeyer 's tonsillar ring Lymph nodes Lymphatic vessel T cells High endothelial venules B cells Germinal center Mantle zone Marginal zone MALT GALT Peyer 's patch Germinal center Bone and cartilage Cartilage perichondrium fibrocartilage callus metaphysis Cells chondroblast chondrocyte Types hyaline elastic fibrous Bone Ossification Primary bone intramembranous endochondral Cells osteoblast osteoid osteocyte osteoclast Types cancellous cortical Regions subchondral bone epiphysis epiphyseal plate / metaphysis diaphysis Condyle Epicondyle Structure Osteon Haversian canals Volkmann 's canals connective tissue endosteum periosteum Sharpey 's fibres enthesis lacunae canaliculi trabeculae medullary cavity bone marrow Shapes long short flat irregular sesamoid GND : 4031332 - 3 NDL : 00566838 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Bone_marrow&oldid=818102238 '' Categories : Bone marrow Skeletal system Hematopoiesis Endocrine system Lymphatic system Stem cells Lymphoid organ Hidden categories : Webarchive template wayback links Use dmy dates from July 2013 Articles containing Latin - language text All articles with unsourced statements Articles with unsourced statements from February 2016 All articles with dead external links Articles with dead external links from July 2017 Articles with permanently dead external links Wikipedia articles with GND identifiers Talk Contents About Wikipedia Afrikaans Aragonés Atikamekw Avañe'ẽ Azərbaycanca বাংলা Bahasa Banjar Беларуская Беларуская ( тарашкевіца ) ‎ Български Bosanski Català Čeština ChiShona Cymraeg Dansk Deutsch Eesti Ελληνικά Español Esperanto Euskara فارسی Français Gaeilge Galego 한국어 Հայերեն हिन्दी Hrvatski Ido Bahasa Indonesia IsiXhosa Italiano עברית Basa Jawa ಕನ್ನಡ ქართული Қазақша Latina Latviešu Lietuvių Magyar Македонски Malagasy മലയാളം Монгол Nederlands 日本 語 Norsk Norsk nynorsk Oʻzbekcha / ўзбекча ਪੰਜਾਬੀ Plattdüütsch Polski Português Română Русский Scots Simple English Slovenčina Slovenščina کوردی Српски / srpski Srpskohrvatski / српскохрватски Basa Sunda Suomi Svenska Tagalog தமிழ் తెలుగు ไทย Türkçe Українська اردو Tiếng Việt ייִדיש 粵語 中文 Edit links This page was last edited on 1 January 2018, at 15 : 52. 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Question: where is the bone marrow located in the body
Answer: within the spongy or cancellous portions of bones