Endometrium - wikipedia Endometrium Endometrium Uterus and uterine tubes. ( Endometrium labeled at center right. ) Endometrium in the proliferative phase Details Part of Uterus Identifiers Latin tunica mucosa uteri MeSH D004717 TA A09. 1.03. 027 FMA 17742 Anatomical terminology ( edit on Wikidata ) The endometrium is the inner epithelial layer, along with its mucous membrane, of the mammalian uterus. It has a basal layer and a functional layer ; the functional layer thickens and then is shed during menstruation in humans. Some other mammals including apes, Old World monkeys, some species of bat, and the elephant shrew menstruate. In most other mammals the endometrium is reabsorbed in the estrous cycle. During pregnancy, the glands and blood vessels in the endometrium further increase in size and number. Vascular spaces fuse and become interconnected, forming the placenta, which supplies oxygen and nutrition to the embryo and fetus. The speculated presence of an endometrial microbiota has been argued against. Contents 1 Structure 1.1 Gene and protein expression 1.2 Microbiome speculation 2 Function 2.1 Cycle 3 Clinical significance 3.1 Embryo transfer 4 Additional images 5 See also 6 References 7 External links Structure High magnification micrograph of decidualized endometrium due to exogenous progesterone ( oral contraceptive pill ). H&E stain Low magnification micrograph of decidualized endometrium. H&E stain The endometrium consists of a single layer of columnar epithelium plus the stroma on which it rests. The stroma is a layer of connective tissue that varies in thickness according to hormonal influences. In the uterus simple tubular glands reach from the endometrial surface through to the base of the stroma, which also carries a rich blood supply provided by the spiral arteries. In a woman of reproductive age, two layers of endometrium can be distinguished. These two layers occur only in the endometrium lining the cavity of the uterus, and not in the lining of the Fallopian tubes. The functional layer is adjacent to the uterine cavity. This layer is built up after the end of menstruation during the first part of the previous menstrual cycle. Proliferation is induced by estrogen ( follicular phase of menstrual cycle ), and later changes in this layer are engendered by progesterone from the corpus luteum ( luteal phase ). It is adapted to provide an optimum environment for the implantation and growth of the embryo. This layer is completely shed during menstruation. The basal layer, adjacent to the myometrium and below the functional layer, is not shed at any time during the menstrual cycle. The functional layer develops on top of it. In the absence of progesterone, the arteries supplying blood to the functional layer constrict, so that cells in that layer become ischaemic and die, leading to menstruation. It is possible to identify the phase of the menstrual cycle by reference to either the ovarian cycle or the uterine cycle by observing microscopic differences at each phase -- for example in the ovarian cycle : Phase Days Thickness Epithelium Menstrual phase 1 -- 5 Thin Absent Follicular phase 5 -- 14 Intermediate Columnar Luteal phase 15 -- 27 Thick Columnar. Also visible are arcuate vessels of uterus Ischemic phase 27 -- 28 Columnar. Also visible are arcuate vessels of uterus Gene and protein expression Further information : Bioinformatics § Gene and protein expression About 20,000 protein coding genes are expressed in human cells and some 70 % of these genes are expressed in the normal endometrium. Just over 100 of these genes are more specifically expressed in the endometrium with only a handful genes being highly endometrium specific. The corresponding specific proteins are expressed in the glandular and stromal cells of the endometrial mucosa. The expression of many of these proteins vary depending on the menstrual cycle, for example the progestorone receptor and thyrotropin - releasing hormone both expressed in the proliferative phase, and PAEP expressed in the secretory phase. Other proteins such as the HOX11 protein that is required for female fertility, is expressed in endometrial stroma cells throughout the menstrual cycle. Certain specific proteins such as the estrogen receptor are also expressed in other types of female tissue types, such as the cervix, fallopian tubes, ovaries and breast. Microbiome speculation The uterus and endometrium was for a long time thought to be sterile. The cervical plug of mucosa was seen to prevent the entry of any microorganisms ascending from the vagina. In the 1980s this view was challenged when it was shown that uterine infections could arise from weaknesses in the barrier of the cervical plug. Organisms from the vaginal microbiota could enter the uterus during uterine contractions in the menstrual cycle. Further studies sought to identify microbiota specific to the uterus which would be of help in identifying cases of unsuccessful IVF and miscarriages. Their findings were seen to be unreliable due to the possibility of cross-contamination in the sampling procedures used. The well - documented presence of Lactobacillus species, for example, was easily explained by an increase in the vaginal population being able to seep into the cervical mucous. Another study highlighted the flaws of the earlier studies including cross-contamination. It was also argued that the evidence from studies using germ - free offspring of axenic animals ( germ - free ) clearly showed the sterility of the uterus. The authors concluded that in light of these findings there was no existence of a microbiome. The normal dominance of Lactobacilli in the vagina is seen as a marker for vaginal health. However, in the uterus this much lower population is seen as invasive in a closed environment that is highly regulated by female sex hormones, and that could have unwanted consequences. In studies of endometriosis Lactobacillus is not the dominant type and there are higher levels of Streptococcus and Staphylococcus species. Half of the cases of bacterial vaginitis showed a polymicrobial biofilm attached to the endometrium. Function The endometrium is the innermost layer of ovary ( female reproductive organ ) and functions as a lining for the uterus, preventing adhesions between the opposed walls of the myometrium, thereby maintaining the patency of the uterine cavity. During the menstrual cycle or estrous cycle, the endometrium grows to a thick, blood vessel - rich, glandular tissue layer. This represents an optimal environment for the implantation of a blastocyst upon its arrival in the uterus. The endometrium is central, echogenic ( detectable using ultrasound scanners ), and has an average thickness of 6.7 mm. During pregnancy, the glands and blood vessels in the endometrium further increase in size and number. Vascular spaces fuse and become interconnected, forming the placenta, which supplies oxygen and nutrition to the embryo and fetus. Cycle The endometrial lining undergoes cyclic regeneration. Humans, apes, and some other species display the menstrual cycle, whereas most other mammals are subject to an estrous cycle. In both cases, the endometrium initially proliferates under the influence of estrogen. However, once ovulation occurs, the ovary ( specifically the corpus luteum ) will produce much larger amounts of progesterone. This changes the proliferative pattern of the endometrium to a secretory lining. Eventually, the secretory lining provides a hospitable environment for one or more blastocysts. Upon fertilization, the egg may implant into the uterine wall and provide feedback to the body with human chorionic gonadotropin ( HCG ). HCG provides continued feedback throughout pregnancy by maintaining the corpus luteum, which will continue its role of releasing progesterone and estrogen. The endometrial lining is either reabsorbed ( estrous cycle ) or shed ( menstrual cycle ). In the latter case, the process of shedding involves the breaking down of the lining, the tearing of small connective blood vessels, and the loss of the tissue and blood that had constituted it through the vagina. The entire process occurs over a period of several days. Menstruation may be accompanied by a series of uterine contractions ; these help expel the menstrual endometrium. In case of implantation, however, the endometrial lining is neither absorbed nor shed. Instead, it remains as decidua. The decidua becomes part of the placenta ; it provides support and protection for the gestation. If there is inadequate stimulation of the lining, due to lack of hormones, the endometrium remains thin and inactive. In humans, this will result in amenorrhea, or the absence of a menstrual period. After menopause, the lining is often described as being atrophic. In contrast, endometrium that is chronically exposed to estrogens, but not to progesterone, may become hyperplastic. Long - term use of oral contraceptives with highly potent progestins can also induce endometrial atrophy. In humans, the cycle of building and shedding the endometrial lining lasts an average of 28 days. The endometrium develops at different rates in different mammals. Various factors including the seasons, climate, and stress can affect its development. The endometrium itself produces certain hormones at different stages of the cycle and this affects other parts of the reproductive system. Clinical significance Chorionic tissue can result in marked endometrial changes, known as an Arias - Stella reaction, that have an appearance similar to cancer. Historically, this change was diagnosed as endometrial cancer and it is important only in so far as it should not be misdiagnosed as cancer. Adenomyosis is the growth of the endometrium into the muscle layer of the uterus ( the myometrium ). Endometriosis is the growth of endometrial tissue outside the uterus. Endometrial hyperplasia Endometrial cancer is the most common cancer of the human female genital tract. Asherman 's syndrome, also known as intrauterine adhesions occurs when the basal layer of the endometrium is damaged by instrumentation ( e.g., D&C ) or infection ( e.g., endometrial tuberculosis ) resulting in endometrial sclerosis and adhesion formation partially or completely obliterating the uterine cavity. Thin endometrium may be defined as an endometrial thickness of less than 8 mm. It usually occurs after menopause. Treatments that can improve endometrial thickness include Vitamin E, L - arginine and sildenafil citrate. Gene expression profiling using cDNA microarray can be used for the diagnosis of endometrial disorders. The European Menopause and Andropause Society ( EMAS ) released Guidelines with detailed information to assess the endometrium. Embryo transfer An endometrial thickness of less than 7 mm decreases the pregnancy rate in in vitro fertilization by an odds ratio of approximately 0.4 compared to an EMT of over 7 mm. However, such low thickness rarely occurs, and any routine use of this parameter is regarded as not justified. Triple - line endometrium measuring 7mm. Observation of the endometrium by transvaginal ultrasonography is used when administering fertility medication, such as in in vitro fertilization. At the time of embryo transfer, it is favorable to have an endometrium of a thickness of between 7 and 14 mm with a triple - line configuration, which means that the endometrium contains a hyperechoic ( usually displayed as light ) line in the middle surrounded by two more hypoechoic ( darker ) lines. A triple - line endometrium reflects the separation of the stratum basalis and functionalis layers, and is also observed in the periovulatory period secondary to rising estradiol levels, and disappears after ovulation. Additional images Endometrioid adenocarcinoma from biopsy. H&E stain. Micrograph of decidualized endometrium due to exogenous progesterone. H&E stain. Micrograph of decidualized endometrium due to exogenous progesterone. H&E stain. Micrograph showing endometrial stromal condensation, a finding seen in menses. See also CYTL1, also known as cytokine - like like protein 1. References ^ Jump up to : Emera, D ; Romero, R ; Wagner, G ( January 2012 ). `` The evolution of menstruation : a new model for genetic assimilation : explaining molecular origins of maternal responses to fetal invasiveness ''. BioEssays : news and reviews in molecular, cellular and developmental biology. 34 ( 1 ) : 26 -- 35. doi : 10.1002 / bies. 201100099. PMC 3528014. PMID 22057551. ^ Jump up to : Blue Histology - Female Reproductive System. School of Anatomy and Human Biology -- The University of Western Australia Accessed 20061228 20 : 35 ^ Jump up to : Guyton AC and Hall JE, eds. ( 2006 ). `` Chapter 81 Female Physiology Before Pregnancy and Female Hormones ''. Textbook of Medical Physiology ( 11th ed. ). Elsevier Saunders. pp. 1018ff. ISBN 9780721602400. CS1 maint : Uses editors parameter ( link ) Jump up ^ Franasiak, Jason M. ; Scott, Richard T. ( 2015 ). `` Reproductive tract microbiome in assisted reproductive technologies ''. Fertility and Sterility. 104 ( 6 ) : 1364 -- 1371. doi : 10.1016 / j. fertnstert. 2015.10. 012. ISSN 0015 - 0282. PMID 26597628. ^ Jump up to : Baker, JM ; Chase, DM ; Herbst - Kralovetz, MM ( 2018 ). `` Uterine Microbiota : Residents, Tourists, or Invaders ? ''. Frontiers in Immunology. 9 : 208. doi : 10.3389 / fimmu. 2018.00208. PMID 29552006. ^ Jump up to : Perez - Muñoz, ME ; Arrieta, MC ; Ramer - Tait, AE ; Walter, J ( 28 April 2017 ). `` A critical assessment of the `` sterile womb '' and `` in utero colonization '' hypotheses : implications for research on the pioneer infant microbiome ``. Microbiome. 5 ( 1 ) : 48. doi : 10.1186 / s40168 - 017 - 0268 - 4. PMID 28454555. Jump up ^ `` The human proteome in endometrium - The Human Protein Atlas ''. www.proteinatlas.org. Retrieved 2017 - 09 - 25. Jump up ^ Uhlén, Mathias ; Fagerberg, Linn ; Hallström, Björn M. ; Lindskog, Cecilia ; Oksvold, Per ; Mardinoglu, Adil ; Sivertsson, Åsa ; Kampf, Caroline ; Sjöstedt, Evelina ( 2015 - 01 - 23 ). `` Tissue - based map of the human proteome ''. Science. 347 ( 6220 ) : 1260419. doi : 10.1126 / science. 1260419. ISSN 0036 - 8075. PMID 25613900. Jump up ^ Zieba, Agata ; Sjöstedt, Evelina ; Olovsson, Matts ; Fagerberg, Linn ; Hallström, Björn M. ; Oskarsson, Linda ; Edlund, Karolina ; Tolf, Anna ; Uhlen, Mathias ( 2015 - 10 - 21 ). `` The Human Endometrium - Specific Proteome Defined by Transcriptomics and Antibody - Based Profiling ''. OMICS : A Journal of Integrative Biology. 19 ( 11 ) : 659 -- 668. doi : 10.1089 / omi. 2015.0115. Jump up ^ Deligdisch, L. ( 1993 ). `` Effects of hormone therapy on the endometrium ''. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 6 ( 1 ) : 94 -- 106. PMID 8426860. Jump up ^ William 's Gynecology, McGraw 2008, Chapter 8, Abnormal Uterine Bleeding Jump up ^ Arias - Stella, J. ( Jan 2002 ). `` The Arias - Stella reaction : facts and fancies four decades after ''. Adv Anat Pathol. 9 ( 1 ) : 12 -- 23. doi : 10.1097 / 00125480 - 200201000 - 00003. PMID 11756756. Jump up ^ Takasaki A, Tamura H, Miwa I, Taketani T, Shimamura K, Sugino N ( April 2010 ). `` Endometrial growth and uterine blood flow : a pilot study for improving endometrial thickness in the patients with a thin endometrium ''. Fertil. Steril. 93 ( 6 ) : 1851 -- 8. doi : 10.1016 / j. fertnstert. 2008.12. 062. PMID 19200982. Jump up ^ Tseng, L. ; Chen, I. ; Chen, M. ; Yan, H. ; Wang, C. ; Lee, C. ( 2010 ). `` Genome - based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder : an array of 126 - gene model ''. Fertility and Sterility. 94 ( 1 ) : 114 -- 119. doi : 10.1016 / j. fertnstert. 2009.01. 130. PMID 19328470. Jump up ^ Dreisler E, Poulsen LG, Antonsen SL, Ceausu I, Depypere H, Erel CT, Lambrinoudaki I, Pérez - López FR, Simoncini T, Tremollieres F, Rees M, Ulrich LG ( 2013 ). `` EMAS clinical guide : Assessment of the endometrium in peri and postmenopausal women ''. Maturita. 75 ( 2 ) : 181 -- 90. doi : 10.1016 / j. maturitas. 2013.03. 011. PMID 23619009. Jump up ^ Kasius, A. ; Smit, J.G. ; Torrance, H.L. ; Eijkemans, M.J.C. ; Mol, B.W. ; Opmeer, B.C. ; Broekmans, F.J.M. ( 2014 ). `` Endometrial thickness and pregnancy rates after IVF : a systematic review and meta - analysis ''. Human Reproduction Update. 20 ( 4 ) : 530 -- 541. doi : 10.1093 / humupd / dmu011. ISSN 1355 - 4786. Jump up ^ Zhao, Jing ; Zhang, Qiong ; Li, Yanping ( 2012 ). `` The effect of endometrial thickness and pattern measured by ultrasonography on pregnancy outcomes during IVF - ET cycles ''. Reproductive Biology and Endocrinology. 10 ( 1 ) : 100. doi : 10.1186 / 1477 - 7827 - 10 - 100. ISSN 1477 - 7827. Jump up ^ Baerwald, A.R. ; Pierson, R.A. ( 2004 ). `` Endometrial development in association with ovarian follicular waves during the menstrual cycle ''. Ultrasound in Obstetrics and Gynecology. 24 ( 4 ) : 453 -- 460. doi : 10.1002 / uog. 1123. ISSN 0960 - 7692. PMC 2891966. External links Anatomy figure : 43 : 05 - 15 at Human Anatomy Online, SUNY Downstate Medical Center - `` The uterus, uterine tubes and ovary with associated structures. '' Histology image : 18902loa -- Histology Learning System at Boston University - `` Female Reproductive System uterus, endometrium '' Swiss embryology ( from UL, UB, and UF ) gnidation / role02 Histology image : 20_01 at the University of Oklahoma Health Sciences Center Histology at utah.edu. Slide is proliferative phase - click forward to see secretory phase Female reproductive system Internal Adnexa Ovaries Follicles corpus hemorrhagicum luteum albicans Theca of follicle externa interna Follicular antrum Follicular fluid Corona radiata Zona pellucida Membrana granulosa Perivitelline space Other Germinal epithelium Tunica albuginea cortex Cumulus oophorus Stroma Medulla Fallopian tubes Isthmus Ampulla Infundibulum Fimbria Ostium Ligaments Ovarian ligament Suspensory ligament Wolffian vestiges Gartner 's duct Epoophoron Vesicular appendages of epoophoron Paroophoron Uterus Regions Body Uterine cavity Fundus Cervix External orifice Cervical canal Internal orifice Supravaginal portion Vaginal portion Uterine horns Layers Endometrium epithelium Myometrium Perimetrium Parametrium Ligaments Round ligament Broad ligament Cardinal ligament Uterosacral ligament Pubocervical ligament General Uterine glands Vagina Fossa of vestibule of vagina Vaginal fornix Hymen Vaginal rugae Support structures Vaginal epithelium External Vulva Labia Mons pubis Labia majora Anterior commissure Posterior commissure Pudendal cleft Labia minora Frenulum of labia minora Frenulum of clitoris Vulval vestibule Interlabial sulci Bulb of vestibule Vaginal orifice vestibular glands / ducts Bartholin 's glands / Bartholin 's ducts Skene 's glands / Skene 's ducts Clitoris Crus of clitoris Corpus cavernosum Clitoral glans Hood Urethra Urethral crest Other G - spot Urethral sponge Perineal sponge Retrieved from `` https://en.wikipedia.org/w/index.php?title=Endometrium&oldid=843267467 '' Categories : Mammal female reproductive system Pelvis Hidden categories : Pages with unresolved properties CS1 maint : Uses editors parameter Talk Contents About Wikipedia Беларуская Bosanski Català Čeština Deutsch Eesti Español Esperanto Euskara Français Galego Bahasa Indonesia Italiano עברית Latina Lietuvių Nederlands 日本 語 Norsk Polski Português Русский Simple English Svenska தமிழ் తెలుగు Українська 中文 20 more Edit links This page was last edited on 28 May 2018, at 00 : 50. 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Question: when does the uterine lining become more vascular
Answer: During pregnancy