Eccrine sweat gland - wikipedia Eccrine sweat gland Eccrine sweat gland A sectional view of the skin ( magnified ), with eccrine glands highlighted. Details Precursor Ectoderm System Integumentary Nerve Cholinergic sympathetic nerves Identifiers Latin Glandula sudorifera merocrina ; Glandula sudorifera eccrina MeSH D004439 TH H3. 12.00. 3.03009 FMA 59154 Anatomical terminology ( edit on Wikidata ) Eccrine glands ( / ˈɛkrən, - ˌkraɪn, - ˌkriːn / ; from ekkrinein `` secrete '' ; sometimes called merocrine glands ) are the major sweat glands of the human body, found in virtually all skin, with the highest density in palms and soles, then on the head, but much less on the trunk and the extremities. In lower mammals, they are relatively sparse, being found mainly on hairless areas such as foot pads. They reach their peak of development in humans, where they may number 200 -- 400 / cm2 of skin surface. They produce a clear, odorless substance, sweat, consisting primarily of water. Eccrine glands are composed of an intraepidermal spiral duct, the `` acrosyringium '' ; a dermal duct, consisting of a straight and coiled portion ; and a secretory tubule, coiled deep in the dermis or hypodermis. The eccrine gland opens out through the sweat pore. The coiled portion is formed by two concentric layer of columnar or cuboidal epithelial cells. The epithelial cells are interposed by the myoepithelial cells. Myoepithelial cells support the secretory epithelial cells. The duct of eccrine gland is formed by two layers of cuboidal epithelial cells. Eccrine glands are active in thermoregulation by providing cooling from water evaporation of sweat secreted by the glands on the body surface and emotional induced sweating ( anxiety, fear, stress, and pain ). The white sediment in otherwise colorless eccrine secretions is caused by evaporation that increases the concentration of salts. The odour from sweat is due to bacterial activity on the secretions of the apocrine sweat glands, a distinctly different type of sweat gland found in human skin. Eccrine glands are innervated by the sympathetic nervous system, primarily by cholinergic fibers whose discharge is altered primarily by changes in deep body temperature ( core temperature ), but by adrenergic fibers as well. The glands on palms and soles do not respond to temperature but secrete at times of emotional stress. Secretion The secretion of eccrine glands is a sterile, dilute electrolyte solution with primary components of bicarbonate, potassium, and sodium chloride ( NaCl ), and other minor components such as glucose, pyruvate, lactate, cytokines, immunoglobulins, antimicrobial peptides ( e.g., dermcidin ), and many others. Relative to the plasma and extracellular fluid, the concentration of Na ions is much lower in sweat ( ~ 40 mM in sweat versus ~ 150 mM in plasma and extracellular fluid ). Initially, within the eccrine glands, sweat has a high concentration of Na ions. The Na ions are re-absorbed into the tissue via the epithelial sodium channels ( ENaC ) that are located on the apical membrane of the cells that form the eccrine gland ducts ( see Fig. 9 and Fig. 10 of the reference ). This re-uptake of Na ions reduces the loss of Na during the process of perspiration. Patients with the systemic pseudohypoaldosteronism syndrome who carry mutations in the ENaC subunit genes have salty sweat as they can not reabsorb the salt in sweat. In these patients, Na ion concentrations can greatly increase ( up to 180 mmol / L ). In people who have hyperhidrosis, the sweat glands ( eccrine glands in particular ) overreact to stimuli and are just generally overactive, producing more sweat than normal. Similarly, cystic fibrosis patients also produce salty sweat. But in these cases, the problem is in the CFTR chloride transporter that is also located on the apical membrane of eccrine gland ducts. Dermcidin is a newly isolated antimicrobial peptide produced by the eccrine sweat glands. References ^ Jump up to : Neas, John F. `` Development of the Integumentary System ''. In Martini, Frederic H. ; Timmons, Michael J. ; Tallitsch, Bob. Embryology Atlas ( 4th ed. ). Benjamin Cumings. Retrieved 17 December 2012. Jump up ^ Krstic, Radivoj V. ( 18 March 2004 ). Human Microscopic Anatomy : An Atlas for Students of Medicine and Biology. Springer. p. 464. ISBN 9783540536666. Jump up ^ `` eccrine ''. The New Oxford American Dictionary ( 2 ed. ). 2005. ISBN 9780195170771. Jump up ^ `` our weird lack of hair may be the key to our success ''. Jump up ^ James, William ; Berger, Timothy ; Elston, Dirk ( 2005 ). Andrews ' Diseases of the Skin : Clinical Dermatology ( 10th ed. ). Saunders. pp. 6 -- 7. ISBN 0 - 7216 - 2921 - 0. ^ Jump up to : Bolognia, J., Jorizzo, J., & Schaffer, J. ( 2012 ). Dermatology ( 3rd ed., pp. 539 - 544 ). ( Philadelphia ) : Elsevier Saunders. ^ Jump up to : Wilke, K. ; Martin, A. ; Terstegen, L. ; Biel, S.S. ( June 2007 ). `` A short history of sweat gland biology '' ( pdf ). International Journal of Cosmetic Science. 29 ( 3 ) : 169 -- 179. doi : 10.1111 / j. 1467 - 2494.2007. 00387. x. ISSN 1468 - 2494. PMID 18489347. Jump up ^ Cui, Chang - Yi ; Schlessinger, David ( 2015 ). `` Eccrine sweat gland development and sweat secretion ''. Experimental Dermatology. 24 ( 9 ) : 644 -- 650. doi : 10.1111 / exd. 12773. ISSN 0906 - 6705. ^ Jump up to : Hanukoglu I, Boggula VR, Vaknine H, Sharma S, Kleyman T, Hanukoglu A ( January 2017 ). `` Expression of epithelial sodium channel ( ENaC ) and CFTR in the human epidermis and epidermal appendages ''. Histochemistry and Cell Biology. 147 ( 6 ) : 733 -- 748. doi : 10.1007 / s00418 - 016 - 1535 - 3. PMID 28130590. Jump up ^ Sokolov, VE ; Shabadash, SA ; Zelikina, TI ( 1980 ). `` Innervation of eccrine sweat glands ''. Biology Bulletin of the Academy of Sciences of the USSR. 7 ( 5 ) : 331 -- 46. PMID 7317512. ^ Jump up to : Hanukoglu A ( Nov 1991 ). `` Type I pseudohypoaldosteronism includes two clinically and genetically distinct entities with either renal or multiple target organ defects ''. The Journal of Clinical Endocrinology and Metabolism. 73 ( 5 ) : 936 -- 44. doi : 10.1210 / jcem - 73 - 5 - 936. PMID 1939532. Jump up ^ Hanukoglu I, Hanukoglu A ( Jan 2016 ). `` Epithelial sodium channel ( ENaC ) family : Phylogeny, structure - function, tissue distribution, and associated inherited diseases ''. Gene. 579 ( 2 ) : 95 -- 132. doi : 10.1016 / j. gene. 2015.12. 061. PMC 4756657. PMID 26772908. Jump up ^ Edelheit, Oded ; Hanukoglu, Israel ; Shriki, Yafit ; Tfilin, Matanel ; Dascal, Nathan ; Gillis, David ; Hanukoglu, Aaron ( 2010 ). `` Truncated beta epithelial sodium channel ( ENaC ) subunits responsible for multi-system pseudohypoaldosteronism ( PHA ) support partial activity of ENaC ''. The Journal of Steroid Biochemistry and Molecular Biology. 119 ( 1 - 2 ) : 84 -- 88. doi : 10.1016 / j. jsbmb. 2010.01. 002. PMID 20064610. Jump up ^ Niyonsaba, F ; Suzuki, A ; Ushio, H ; Nagaoka, I ; Ogawa, H ; Okumura, K ( 2009 ). `` The human antimicrobial peptide dermcidin activates normal human keratinocytes ''. The British Journal of Dermatology. 160 ( 2 ) : 243 -- 9. doi : 10.1111 / j. 1365 - 2133.2008. 08925. x. PMID 19014393. External links A video of 3D visualization of a human eccrine gland duct Skin and related structures Skin Epidermis Stratum corneum Stratum lucidum Stratum granulosum Stratum spinosum Stratum basale Basement membrane Basal keratinocyte Lamina lucida Lamina densa Dermis Papillary Dermal papillae Reticular Subcutaneous tissue Panniculus / Pannus ( Panniculus adiposus Panniculus carnosus ) Membranous layer Loose connective tissue Superficial fascia Adnexa Skin glands Sweat glands : Apocrine sweat gland Eccrine sweat gland Sebaceous Hair Root sheath Outer root sheath Inner root sheath Henle 's layer Huxley 's layer Hair shaft Cuticle Cortex Medulla Bulb with matrix cells Hair follicle Muscle Arrector pili muscle Pilosebaceous unit Hair sebaceous gland Nail Nail matrix Nail plate Lunula Eponychium Paronychium Hyponychium Retrieved from `` https://en.wikipedia.org/w/index.php?title=Eccrine_sweat_gland&oldid=835123465 '' Categories : Skin anatomy Hidden categories : Pages with unresolved properties Talk About Wikipedia Català Italiano 日本 語 Polski Русский Türkçe Edit links This page was last edited on 6 April 2018, at 18 : 11. 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Question: sweat glands are found primarily in or on the
Answer: skin