Hashimoto 's thyroiditis - wikipedia Hashimoto 's thyroiditis Hashimoto 's thyroiditis Synonyms Chronic lymphocytic thyroiditis, autoimmune thyroiditis, struma lymphomatosa, Hashimoto 's disease The thyroid of someone with Hashimoto 's thyroiditis as seen with a microscope at low magnification Specialty Endocrinology Symptoms Painless goiter, weight gain, feeling tired, constipation, depression Complications Thyroid lymphoma. Usual onset 30 -- 50 years old Causes Genetic and environmental factors. Risk factors Family history, another autoimmune disease Diagnostic method TSH, T4, antithyroid antibodies Similar conditions Graves ' disease, nontoxic nodular goiter Treatment Levothyroxine, surgery Frequency 5 % at some point ( edit on Wikidata ) Hashimoto 's thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto 's disease, is an autoimmune disease in which the thyroid gland is gradually destroyed. Early on there may be no symptoms. Over time the thyroid may enlarge forming a painless goiter. Some people eventually develop hypothyroidism with its accompanying weight gain, feeling tired, constipation, depression, and general pains. After many years the thyroid typically shrinks in size. Potential complications include thyroid lymphoma. Hashimoto 's thyroiditis is thought to be due to a combination of genetic and environmental factors. Risk factors include a family history of the condition and having another autoimmune disease. Diagnosis is confirmed with blood tests for TSH, T4, and antithyroid antibodies. Other conditions that can produce similar symptoms include Graves ' disease and nontoxic nodular goiter. Hashimoto 's thyroiditis, regardless of whether or not hypothyroidism is present, can be treated with levothyroxine. If hypothyroidism is not present some may recommend no treatment while others may treat to try to reduce the size of the goiter. Those affected should avoid eating large amounts of iodine ; however, sufficient iodine is required especially during pregnancy. Surgery is rarely required to treat the goiter. Hashimoto 's thyroiditis affects about 5 % of the population at some point in their life. It typically begins between the ages of 30 and 50 and is much more common in women than men. Rates of disease appear to be increasing. It was first described by the Japanese physician Hakaru Hashimoto in 1912. In 1957 it was recognized as an autoimmune disorder. Contents 1 Signs and symptoms 2 Risk factors 3 Pathophysiology 4 Diagnosis 5 Treatment 5.1 Managing hormone levels 6 Prognosis 7 Epidemiology 8 History 9 Pregnancy 10 See also 11 References 12 External links Signs and symptoms There are many symptoms that are attributed to Hashimoto 's thyroiditis or Hashimoto 's disease. The most common symptoms include the following : fatigue, weight gain, pale or puffy face, feeling cold, joint and muscle pain, constipation, dry and thinning hair, heavy menstrual flow or irregular periods, depression, panic disorder, a slowed heart rate, and problems getting pregnant and maintaining pregnancy. Hashimoto 's disease is about seven times more common in women than in men. It can occur in teens and young women, but more commonly shows up in middle age, particularly for men. People who develop Hashimoto 's disease often have family members who have thyroid or other autoimmune diseases, and sometimes have other autoimmune diseases themselves. The thyroid gland may become firm, large, and lobulated in Hashimoto 's thyroiditis, but changes in the thyroid can also be nonpalpable. Enlargement of the thyroid is due to lymphocytic infiltration and fibrosis rather than tissue hypertrophy. Physiologically, antibodies against thyroid peroxidase ( TPO ) ( also called TPOAb ) and / or thyroglobulin cause gradual destruction of follicles in the thyroid gland. Accordingly, the disease can be detected clinically by looking for these antibodies in the blood. It is also characterized by invasion of the thyroid tissue by leukocytes, mainly T - lymphocytes. A rare but serious complication is thyroid lymphoma, generally the B - cell type, non-Hodgkin lymphoma. Risk factors The strong genetic component is borne out in studies on monozygotic twins, with a concordance of 38 - 55 %, with an even higher concordance of circulating thyroid antibodies not in relation to clinical presentation ( up to 80 % in monozygotic twins ). Neither result was seen to a similar degree in dizygotic twins, offering strong favour for high genetic aetiology. Hashimoto 's thyroiditis is associated with CTLA - 4 ( Cytotoxic T - lymphocyte Antigen - 4 ) gene polymorphisms. CTLA - 4 downregulates., i.e. transmits an inhibitory signal to T cells so reduced functioning is associated with increased T - lymphocyte activity. A family history of thyroid disorders is common, with the HLA - DR5 gene most strongly implicated conferring a relative risk of 3 in the UK. Having another autoimmune diseases is a risk factor to develop Hashimoto 's thyroiditis, and the opposite is also true. Autoimmune diseases most commonly associated to Hashimoto 's thyroiditis include celiac disease, type 1 diabetes, vitiligo, and alopecia. Preventable environmental factors, including high iodine intake, selenium deficiency, as well as infectious diseases and certain drugs, have been implicated in the development of autoimmune thyroid disease in genetically predisposed individuals. The genes implicated vary in different ethnic groups and the incidence is increased in people with chromosomal disorders, including Turner, Down, and Klinefelter syndromes usually associated with autoantibodies against thyroglobulin and thyroperoxidase. Progressive depletion of these cells as the cytotoxic immune response leads to higher degrees of primary hypothyroidism, presenting with a poverty of T3 / T4 levels, and compensatory elevations of TSH. Pathophysiology There are multiple suggested mechanisms by which the pathology of Hashimoto 's thyroiditis develops. Various autoantibodies may be present against thyroid peroxidase, thyroglobulin and TSH receptors, although a small percentage of people may have none of these antibodies present. As indicated in various twin studies a percentage of the population may also have these antibodies without developing Hashimoto 's thyroiditis. Nevertheless, antibody - dependent cell - mediated cytotoxicity is a substantial factor behind the apoptotic fall - out of Hashimoto 's thyroiditis. Activation of cytotoxic T - lymphocytes ( CD8 + T - cells ) in response to cell - mediated immune response affected by helper T - lymphocytes ( CD4 + T - cells ) is central to thyrocyte destruction. As is characteristic of type IV hypersensitivities, recruitment of macrophages is another effect of the helper T - lymphocyte activation, with Th1 axis lymphocytes producing inflammatory cytokines within thyroid tissue to further macrophage activation and migration into the thyroid gland for direct effect. Gross morphological changes within the thyroid are seen in the general enlargement which is far more locally nodular and irregular than more diffuse patterns ( such as that of hyperthyroidism ). While the capsule is intact and the gland itself is still distinct from surrounding tissue, microscopic examination can provide a more revealing indication of the level of damage. Histologically, the hypersensitivity is seen as diffuse parenchymal infiltration by lymphocytes, particularly plasma B - cells, which can often be seen as secondary lymphoid follicles ( germinal centers, not to be confused with the normally present colloid - filled follicles that constitute the thyroid ). Atrophy of the colloid bodies is lined by Hürthle cells, cells with intensely eosinophilic, granular cytoplasm, a metaplasia from the normal cuboidal cells that constitute the lining of the thyroid follicles. Severe thyroid atrophy presents often with denser fibrotic bands of collagen that remains within the confines of the thyroid capsule. Diagnosis Ultrasound imaging of the thyroid gland ( right lobe longitudinal ) in a person with Hashimoto thyroiditis. Diagnosis is usually made by detecting elevated levels of anti-thyroid peroxidase antibodies ( TPOAb ) in the serum, but seronegative ( without circulating autoantibodies ) thyroiditis is also possible. Given the relatively non-specific symptoms of initial hypothyroidism, Hashimoto 's thyroiditis is often misdiagnosed as depression, cyclothymia, PMS, chronic fatigue syndrome, fibromyalgia and, less frequently, as erectile dysfunction or an anxiety disorder. On gross examination, there is often presentation of a hard goiter that is not painful to the touch ; other symptoms seen with hypothyroidism, such as periorbital myxedema, depend on the current state of progression of the response, especially given the usually gradual development of clinically relevant hypothyroidism. Testing for thyroid - stimulating hormone ( TSH ), free T3, free T4, and the anti-thyroglobulin antibodies ( anti-Tg ), anti-thyroid peroxidase antibodies ( anti-TPO, or TPOAb ) and anti-microsomal antibodies can help obtain an accurate diagnosis. Earlier assessment of the person may present with elevated levels of thyroglobulin owing to transient thyrotoxicosis, as inflammation within the thyroid causes damage to the integrity of thyroid follicle storage of thyroglobulin ; TSH is increased as the pituitary tries to increase production of T4 by the thyroid gland. This exposure of the body to substantial amounts of previously isolated thyroid enzymes is thought to contribute to the exacerbation of tolerance breakdown, giving rise to the more pronounced symptoms seen later in the disease. Lymphocytic infiltration of the thyrocyte - associated tissues often leads to the histologically significant finding of germinal center development within the thyroid gland. Hashimoto 's when presenting as mania is known as Prasad 's syndrome after Ashok Prasad, the psychiatrist who first described it. Treatment Managing hormone levels Hypothyroidism caused by Hashimoto 's thyroiditis is treated with thyroid hormone replacement agents such as levothyroxine, triiodothyronine or desiccated thyroid extract. A tablet taken once a day generally keeps the thyroid hormone levels normal. In most cases, the treatment needs to be taken for the rest of the person 's life. In the event that hypothyroidism is caused by Hashimoto 's thyroiditis, it is recommended that the TSH levels be kept under 3.0. Prognosis Overt, symptomatic thyroid dysfunction is the most common complication, with about 5 % of persons with subclinical hypothyroidism and chronic autoimmune thyroiditis progressing to thyroid failure every year. Transient periods of thyrotoxicosis ( over-activity of the thyroid ) sometimes occur, and rarely the illness may progress to full hyperthyroid Graves ' disease with active orbitopathy ( bulging, inflamed eyes ). Rare cases of fibrous autoimmune thyroiditis present with severe dyspnea ( shortness of breath ) and dysphagia ( difficulty swallowing ), resembling aggressive thyroid tumors -- but such symptoms always improve with surgery or corticosteroid therapy. Primary thyroid B cell lymphoma affects fewer than one in a thousand persons, and it is more likely to affect those with long - standing autoimmune thyroiditis. Epidemiology This disorder is believed to be the most common cause of primary hypothyroidism in North America ; as a cause of non-endemic goiter, it is among the most common. Hashimoto 's thyroiditis affects about 5 % of the population at some point in their life. About 1 to 1.5 in 1000 people have this disease at any point in time. It occurs between eight and fifteen times more often in women than in men. Though it may occur at any age, including in children, it is most often observed in women between 30 and 60 years of age. It is more common in regions of high iodine dietary intake, and among people who are genetically susceptible. History Also known as Hashimoto 's disease, Hashimoto 's thyroiditis is named after the Japanese physician Hakaru Hashimoto ( 1881 − 1934 ) of the medical school at Kyushu University, who first described the symptoms of persons with struma lymphomatosa, an intense infiltration of lymphocytes within the thyroid, in 1912 in a German publication. The report gave new insight into a condition ( hypothyroidism ) more commonly seen in areas of iodine deficiency that was occurring in the developed world, and without evident causation by dietary deficiency. In 1957 it was recognized as an autoimmune disorder and was the first organ - specific one identified. Pregnancy Pregnant women who are positive for Hashimoto 's thyroiditis may have decreased thyroid function or the gland may fail entirely. If a woman is TPOAb - positive, clinicians can inform her of the risks for themselves and their infants if they go untreated. `` Thyroid peroxidase antibodies ( TPOAb ) are detected in 10 % of pregnant women, '' which presents risks to those pregnancies. Women who have low thyroid function that has not been stabilized are at greater risk of having an infant with : low birth weight, neonatal respiratory distress, hydrocephalus, hypospadias, miscarriage, and preterm delivery. The embryo transplantion rate and successful pregnancy outcomes are improved when Hashimoto 's is treated. Recommendations are to only treat pregnant women who are TPOAb - positive throughout the entirety of their pregnancies and to screen all pregnant women for thyroid levels. Close cooperation between the endocrinologist and obstetrician benefits the woman and the infant. The Endocrine Society recommends screening in pregnant women who are considered high - risk for thyroid autoimmune disease. Thyroid peroxides antibodies testing is recommended for women who have ever been pregnant regardless of pregnancy outcome. ``... ( P ) revious pregnancy plays a major role in development of autoimmune overt hypothyroidism in premenopausal women, and the number of previous pregnancies should be taken into account when evaluating the risk of hypothyroidism in a young women ( sic ). '' See also Hashimoto 's encephalopathy Myxedematous psychosis References ^ Jump up to : `` Hashimoto 's Disease ''. NIDDK. May 2014. Archived from the original on 22 August 2016. Retrieved 9 August 2016. ^ Jump up to : Noureldine, SI ; Tufano, RP ( January 2015 ). `` Association of Hashimoto 's thyroiditis and thyroid cancer. ''. Current Opinion in Oncology. 27 ( 1 ) : 21 -- 5. PMID 25390557. doi : 10.1097 / cco. 0000000000000150. ^ Jump up to : Hiromatsu, Y ; Satoh, H ; Amino, N ( 2013 ). `` Hashimoto 's thyroiditis : history and future outlook. ''. Hormones ( Athens, Greece ). 12 ( 1 ) : 12 -- 8. PMID 23624127. ^ Jump up to : Pyzik, A ; Grywalska, E ; Matyjaszek - Matuszek, B ; Roliński, J ( 2015 ). `` Immune disorders in Hashimoto 's thyroiditis : what do we know so far ? ''. Journal of immunology research. 2015 : 979167. PMC 4426893. PMID 26000316. doi : 10.1155 / 2015 / 979167. ^ Jump up to : Akamizu, T ; Amino, N ; DeGroot, LJ ; De Groot, LJ ; Beck - Peccoz, P ; Chrousos, G ; Dungan, K ; Grossman, A ; Hershman, JM ; Koch, C ; McLachlan, R ; New, M ; Rebar, R ; Singer, F ; Vinik, A ; Weickert, MO ( 2000 ). `` Hashimoto 's Thyroiditis ''. PMID 25905412. Jump up ^ `` Hashimoto 's disease ''. Office on Women 's Health, U.S. Department of Health and Human Services. 12 June 2017. Archived from the original on 28 July 2017. Retrieved 17 July 2017. This article incorporates text from this source, which is in the public domain. Jump up ^ Shoenfeld, Yehuda ; Cervera, Ricard ; Gershwin, M. Eric ( 2010 ). Diagnostic Criteria in Autoimmune Diseases. Springer Science & Business Media. p. 216. ISBN 9781603272858. Archived from the original on 8 September 2017. ^ Jump up to : Moore, Elaine A. ; Wilkinson, Samantha ( 2009 ). The Promise of Low Dose Naltrexone Therapy : Potential Benefits in Cancer, Autoimmune, Neurological and Infectious Disorders. McFarland. p. 30. ISBN 9780786452583. Archived from the original on 8 September 2017. Jump up ^ `` Hashimoto 's disease fact sheet ''. Office on Women 's Health, U.S. Department of Health and Human Services, womenshealth.gov ( or girlshealth.gov ). 16 July 2012. Archived from the original on 2 December 2014. Retrieved 23 November 2014. Jump up ^ Page 56 Archived 21 March 2017 at the Wayback Machine. in : Staecker, Hinrich ; Thomas R. Van De Water ; Van de Water, Thomas R. ( 2006 ). Otolaryngology : basic science and clinical review. Stuttgart : Thieme. ISBN 0 - 86577 - 901 - 5. CS1 maint : Multiple names : authors list ( link ) Jump up ^ Dayan CM, Daniels GH ( 1996 ). `` Chronic autoimmune thyroiditis ''. N Engl J Med. pp. 335 : 99 -- 107. Archived from the original on 13 April 2014. Retrieved 11 April 2014. Jump up ^ Chistiakov, Dimitry A ( 2005 ). `` Immunogenetics of Hashimoto 's thyroiditis ''. Journal of Autoimmune Diseases. 2 ( 1 ) : 1. PMC 555850. PMID 15762980. doi : 10.1186 / 1740 - 2557 - 2 - 1. Jump up ^ Kavvoura, F.K. ; Akamizu, T. ; Awata, T. ; Ban, Y. ; Chistiakov, D.A. ; Frydecka, I. ; Ghaderi, A. ; Gough, S.C. ; Hiromatsu, Y. ( 2007 ). `` Cytotoxic T - Lymphocyte Associated Antigen 4 Gene Polymorphisms and Autoimmune Thyroid Disease : A Meta - Analysis ''. Journal of Clinical Endocrinology & Metabolism. 92 ( 8 ) : 3162 -- 70. PMID 17504905. doi : 10.1210 / jc. 2007 - 0147. Jump up ^ Jacobson, Eric M. ; Tomer, Yaron ( 2007 ). `` The CD40, CTLA - 4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity : Back to the future ''. Journal of Autoimmunity. 28 ( 2 -- 3 ) : 85 -- 98. PMC 2043086. PMID 17369021. doi : 10.1016 / j. jaut. 2007.02. 006. Jump up ^ Radetti G ( 2014 ). `` Clinical aspects of Hashimoto 's thyroiditis. ''. Endocr Dev ( Review ). 26 : 158 -- 70. PMID 25231451. doi : 10.1159 / 000363162. Jump up ^ Saranac, L. ; Zivanovic, S. ; Bjelakovic, B. ; Stamenkovic, H. ; Novak, M. ; Kamenov, B. ( 2011 ). `` Why is the Thyroid So Prone to Autoimmune Disease ''. Hormone Research in Paediatrics. 75 ( 3 ) : 157 -- 65. PMID 21346360. doi : 10.1159 / 000324442. ^ Jump up to : Kumar, Vinay ( 2010 ). `` 24 : The Endocrine System ''. Robbins and Cotran Pathologic Mechanisms of Disease ( 8th ed. ). Philadelphia, PA : Elsevier. p. 1113. Jump up ^ Kumar, Vinay ( 2010 ). `` 24 : The Endocrine System ''. Robbins and Cotran Pathologic Mechanisms of Disease ( 8th ed. ). Philadelphia, PA : Elsevier. pp. 1112 -- 1113. Jump up ^ Grani, Giorgio ; Carbotta, Giovanni ; Nesca, Angela ; D'Alessandri, Mimma ; Vitale, Martina ; Del Sordo, Marianna ; Fumarola, Angela ( 4 October 2014 ). `` A comprehensive score to diagnose Hashimoto 's thyroiditis : a proposal ''. Endocrine. doi : 10.1007 / s12020 - 014 - 0441 - 5. Jump up ^ Giannini, AJ ( 1986 ). The Biological Foundations of Clinical Psychiatry. New Hyde Park, NY : Medical Examination Publishing Company. pp. 193 -- 198. ISBN 0 - 87488 - 449 - 7. Jump up ^ `` Prasad 's syndrome '' ( PDF ). Archived from the original on 9 June 2011. Jump up ^ `` Does Your Doctor Know About the New TSH Lab Standards ? ''. Archived from the original on 4 December 2010. ^ Jump up to : Fabrizio Monaco ( 2012 ). Thyroid Diseases. Taylor and Francis. p. 78. ISBN 9781439868393. ^ Jump up to : Kumar, Vinay ( 2010 ). `` 24 : The Endocrine System ''. Robbins and Cotran Pathologic Mechanisms of Disease ( 8th ed. ). Philadelphia, PA : Elsevier. pp. 1111 -- 205. Jump up ^ Hakaru Hashimoto at Who Named It ? Jump up ^ Hashimoto, H. ( 1912 ). `` Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse ( Struma lymphomatosa ) ''. Archiv für Klinische Chirurgie ( in German ). Berlin. 97 : 219 -- 248. ^ Jump up to : Lepoutre, Thibault ; Debiève, Frederic ; Gruson, Damien ; Daumerie, Chantal ( 1 January 2012 ). `` Reduction of Miscarriages through Universal Screening and Treatment of Thyroid Autoimmune Diseases ''. Gynecologic and Obstetric Investigation. 74 ( 4 ) : 265 -- 273. doi : 10.1159 / 000343759. Archived from the original on 8 September 2017. ^ Jump up to : Zaletel, Katja ( 2011 ). `` Thyroid physiology and autoimmunity in pregnancy and after delivery ''. Expert review of clinical immunology. 7 : 697 -- 707. doi : 10.1586 / eci. 11.42. Retrieved 4 October 2015. Jump up ^ Budenhofer, Brigitte K. ; Ditsch, Nina ; Jeschke, Udo ; Gärtner, Roland ; Toth, Bettina ( 2012 - 10 - 27 ). `` Thyroid ( dys - ) function in normal and disturbed pregnancy ''. Archives of Gynecology and Obstetrics. 287 ( 1 ) : 1 -- 7. ISSN 0932 - 0067. doi : 10.1007 / s00404 - 012 - 2592 - z. Jump up ^ Balucan, Francis S. ; Morshed, Syed A. ; Davies, Terry F. ( 1 January 2013 ). `` Thyroid Autoantibodies in Pregnancy : Their Role, Regulation and Clinical Relevance ''. Journal of Thyroid Research. 2013 : 1 -- 15. PMC 3652173. PMID 23691429. doi : 10.1155 / 2013 / 182472. Archived from the original on 31 October 2015. Jump up ^ `` Endocrine Experts Support Screening for Thyroid Dysfunction in Pregnant Women ''. Endocrine Society. Endocrine Society. 26 March 2015. Archived from the original on 8 October 2015. Retrieved 4 October 2015. Jump up ^ Carlé, Allan ; Pedersen, Inge Bülow ; Knudsen, Nils ; Perrild, Hans ; Ovesen, Lars ; Rasmussen, Lone Banke ; Laurberg, Peter ( 2014 - 04 - 02 ). `` Development of Autoimmune Overt Hypothyroidism Is Highly Associated With Live Births and Induced Abortions but Only in Premenopausal Women ''. The Journal of Clinical Endocrinology & Metabolism. 99 ( 6 ) : 2241 -- 2249. ISSN 0021 - 972X. doi : 10.1210 / jc. 2013 - 4474. External links Classification V T D ICD - 10 : E06. 3 ICD - 9 - CM : 245.2 OMIM : 140300 MeSH : D050031 DiseasesDB : 5649 External resources eMedicine : med / 949 Patient UK : Hashimoto 's thyroiditis Hashimoto 's disease at the Mayo Clinic Hall, Richard C.W. ; Popkin, Michael K. ; Devaul, Richard ; Hall, Anne K. ; Gardner, Earl R. ; Beresford, Thomas P. ( April 1986 ). `` Psychiatric manifestations of Hashimoto 's thyroiditis '' ( PDF ). Psychosomatics. 23 ( 4 ) : 337 -- 42. PMID 6896238. doi : 10.1016 / S0033 - 3182 ( 82 ) 73397 - 3. Diseases of the endocrine system ( E00 -- E35, 240 -- 259 ) Pancreas / glucose metabolism Hypofunction Diabetes mellitus types : type 1 type 2 gestational MODY 1 2 3 4 5 6 complications coma angiopathy ketoacidosis nephropathy neuropathy retinopathy cardiomyopathy insulin receptor ( Rabson -- Mendenhall syndrome ) Insulin resistance Hyperfunction Hypoglycemia beta cell ( Hyperinsulinism ) G cell ( Zollinger -- Ellison syndrome ) Hypothalamic / pituitary axes Hypothalamus gonadotropin Kallmann syndrome Adiposogenital dystrophy CRH ( Tertiary adrenal insufficiency ) vasopressin ( Neurogenic diabetes insipidus ) general ( Hypothalamic hamartoma ) Pituitary Hyperpituitarism anterior Acromegaly Hyperprolactinaemia Pituitary ACTH hypersecretion posterior ( SIADH ) general ( Nelson 's syndrome ) Hypopituitarism anterior Kallmann syndrome Growth hormone deficiency Hypoprolactinemia ACTH deficiency / Secondary adrenal insufficiency GnRH insensitivity FSH insensitivity LH / hCG insensitivity posterior ( Neurogenic diabetes insipidus ) general Empty sella syndrome Pituitary apoplexy Sheehan 's syndrome Lymphocytic hypophysitis Thyroid Hypothyroidism Iodine deficiency Cretinism Congenital hypothyroidism Myxedema Euthyroid sick syndrome Hyperthyroidism Hyperthyroxinemia Thyroid hormone resistance Familial dysalbuminemic hyperthyroxinemia Hashitoxicosis Thyrotoxicosis factitia Graves ' disease Thyroiditis Acute infectious Subacute De Quervain 's Subacute lymphocytic Autoimmune / chronic Hashimoto 's Postpartum Riedel 's Goitre Endemic goitre Toxic nodular goitre Toxic multinodular goiter Thyroid nodule Parathyroid Hypoparathyroidism Hypoparathyroidism Pseudohypoparathyroidism Pseudopseudohypoparathyroidism Hyperparathyroidism Primary Secondary Tertiary Osteitis fibrosa cystica Adrenal Hyperfunction aldosterone : Hyperaldosteronism / Primary aldosteronism Conn syndrome Bartter syndrome Glucocorticoid remediable aldosteronism AME Liddle 's syndrome 17α CAH cortisol : Cushing 's syndrome ( Pseudo-Cushing's syndrome ) sex hormones : 21α CAH 11β CAH Hypofunction / Adrenal insufficiency ( Addison 's, WF ) aldosterone : Hypoaldosteronism 21α CAH 11β CAH cortisol : CAH Lipoid 3β 11β 17α 21α sex hormones : 17α CAH Gonads ovarian : Polycystic ovary syndrome Premature ovarian failure testicular : enzymatic 5α - reductase deficiency 17β - hydroxysteroid dehydrogenase deficiency aromatase excess syndrome ) Androgen receptor ( Androgen insensitivity syndrome ) general : Hypogonadism ( Delayed puberty ) Hypergonadism Precocious puberty Hypoandrogenism Hypoestrogenism Hyperandrogenism Hyperestrogenism Postorgasmic illness syndrome Height Dwarfism / Short stature Midget Laron syndrome Psychosocial Ateliosis Gigantism Multiple Autoimmune polyendocrine syndrome multiple APS1 APS2 Carcinoid syndrome Multiple endocrine neoplasia 2A 2B Progeria Werner syndrome Acrogeria Metageria Woodhouse - Sakati syndrome Hypersensitivity and autoimmune diseases ( 279.5 -- 6 ) Type I / allergy / atopy ( IgE ) Foreign Atopic eczema Allergic urticaria Allergic rhinitis ( Hay fever ) Allergic asthma Anaphylaxis Food allergy common allergies include : Milk Egg Peanut Tree nut Seafood Soy Wheat Penicillin allergy Autoimmune Eosinophilic esophagitis Type II / ADCC IgM IgG Foreign Hemolytic disease of the newborn Autoimmune Cytotoxic Autoimmune hemolytic anemia Immune thrombocytopenic purpura Bullous pemphigoid Pemphigus vulgaris Rheumatic fever Goodpasture 's syndrome Guillain -- Barré syndrome `` Type V '' / receptor Graves ' disease Myasthenia gravis Pernicious anemia Type III ( Immune complex ) Foreign Henoch -- Schönlein purpura Hypersensitivity vasculitis Reactive arthritis Farmer 's lung Post-streptococcal glomerulonephritis Serum sickness Arthus reaction Autoimmune Systemic lupus erythematosus Subacute bacterial endocarditis Rheumatoid arthritis Type IV / cell - mediated ( T cells ) Foreign Allergic contact dermatitis Mantoux test Autoimmune Diabetes mellitus type 1 Hashimoto 's thyroiditis Multiple sclerosis Coeliac disease Giant - cell arteritis Postorgasmic illness syndrome Reactive arthritis GVHD Transfusion - associated graft versus host disease Unknown / multiple Foreign Hypersensitivity pneumonitis Allergic bronchopulmonary aspergillosis Transplant rejection Latex allergy ( I + IV ) Autoimmune Sjögren 's syndrome Autoimmune hepatitis Autoimmune polyendocrine syndrome APS1 APS2 Autoimmune adrenalitis Systemic autoimmune disease GND : 4357666 - 7 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Hashimoto%27s_thyroiditis&oldid=801806040 '' Categories : Aging - associated diseases Autoimmune diseases Thyroid disease Hidden categories : Webarchive template wayback links CS1 maint : Multiple names : authors list CS1 German - language sources ( de ) Use dmy dates from June 2011 All articles with unsourced statements Articles with unsourced statements from February 2017 Articles with unsourced statements from August 2013 Articles with unsourced statements from May 2014 Wikipedia articles with GND identifiers RTT RTTNEURO Talk Contents About Wikipedia Azərbaycanca Bosanski Català Deutsch Ελληνικά Español Esperanto فارسی Français Հայերեն Hrvatski Italiano עברית ქართული Magyar Македонски Nederlands 日本 語 ଓଡ଼ିଆ Polski Português Русский Simple English Suomi Svenska Türkçe Українська 中文 Edit links This page was last edited on 22 September 2017, at 00 : 03. 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Question: where did the name hashimoto disease come from
Answer: Hakaru Hashimoto