Motor unit - wikipedia Motor unit A motor unit is made up of a motor neuron and the skeletal muscle fibers innervated by that motor neuron 's axonal terminals. Groups of motor units often work together to coordinate the contractions of a single muscle ; all of the motor units within a muscle are considered a motor pool. The concept was proposed by Charles Scott Sherrington. All muscle fibres in a motor unit are of the same fibre type. When a motor unit is activated, all of its fibres contract. In vertebrates, the force of a muscle contraction is controlled by the number of activated motor units. The number of muscle fibers within each unit can vary within a particular muscle and even more from muscle to muscle ; the muscles that act on the largest body masses have motor units that contain more muscle fibers, whereas smaller muscles contain fewer muscle fibers in each motor unit. For instance, thigh muscles can have a thousand fibers in each unit, while extraocular muscles might have ten. Muscles which possess more motor units ( and thus have greater individual motor neuron innervation ) are able to control force output more finely. Motor units are organized slightly differently in invertebrates ; each muscle has few motor units ( typically less than 10 ), and each muscle fiber is innervated by multiple neurons, including excitatory and inhibitory neurons. Thus, while in vertebrates the force of contraction of muscles is regulated by how many motor units are activated, in invertebrates it is controlled by regulating the balance between excitatory and inhibitory signals. Contents 1 Recruitment ( vertebrate ) 2 Motor unit types ( vertebrate ) 3 See also 4 References 5 External links Recruitment ( vertebrate ) The central nervous system is responsible for the orderly recruitment of motor neurons, beginning with the smallest motor units. Henneman 's size principle indicates that motor units are recruited from smallest to largest based on the size of the load. For smaller loads requiring less force, slow twitch, low - force, fatigue - resistant muscle fibers are activated prior to the recruitment of the fast twitch, high - force, less fatigue - resistant muscle fibers. Larger motor units are typically composed of faster muscle fibers that generate higher forces. The central nervous system has two distinct ways of controlling the force produced by a muscle through motor unit recruitment : spatial recruitment and temporal recruitment. Spatial recruitment is the activation of more motor units to produce a greater force. Larger motor units contract along with small motor units until all muscle fibers in a single muscle are activated, thus producing the maximum muscle force. Temporal motor unit recruitment, or rate coding, deals with the frequency of activation of muscle fiber contractions. Consecutive stimulation on the motor unit fibres from the alpha motor neuron causes the muscle to twitch more frequently until the twitches `` fuse '' temporally. This produces a greater force than singular contractions by decreasing the interval between stimulations to produce a larger force with the same number of motor units. Using electromyography ( EMG ), the neural strategies of muscle activation can be measured. Ramp - force threshold refers to an index of motor neuron size in order to test the size principle. This is tested by determining the recruitment threshold of a motor unit during isometric contraction in which the force is gradually increased. Motor units recruited at low force ( low - threshold units ) tend to be small motor units, while high - threshold units are recruited when higher forces are needed and involve larger motor neurons. These tend to have shorter contraction times than the smaller units. The number of additional motor units recruited during a given increment of force declines sharply at high levels of voluntary force. This suggests that, even though high threshold units generate more tension, the contribution of recruitment to increase voluntary force declines at higher force levels. To test motor unit stimulation, electrodes are placed extracellularly on the skin and an intramuscular stimulation is applied. After the motor unit is stimulated, its pulse is then recorded by the electrode and displayed as an action potential, known as a motor unit action potential ( MUAP ). When multiple MUAP 's are recorded within a short time interval, a motor unit action potential train ( MUAPT ) is then noted. The time in between these pulses is known as the inter-pulse interval ( IPI ). In medical electrodiagnostic testing for a patient with weakness, careful analysis of the MUAP size, shape, and recruitment pattern can help in distinguishing a myopathy from a neuropathy. Motor unit types ( vertebrate ) Motor units are generally categorized based upon the similarities between several factors : Physiological Contraction speed in Isometric contractions Rate of rise of force Time to peak of a twitch contraction ( response to a single nerve impulse ) FF -- Fast fatigable -- high force, fast contraction speed but fatigue in a few seconds. FR -- Fast fatigue resistant -- intermediate force, fatigue resistant -- fast contraction speed and resistant to fatigue. FI -- Fast intermediate -- intermediate between FF and FR. S or SO -- Slow ( oxidative ) -- low force, slower contraction speed, highly fatigue resistant. Biochemical Histochemical ( the oldest form of biochemical fiber typing ) Glycolytic enzyme activity ( e.g. glycerophosphate dehydrogenase ( GPD ) ) Oxidative enzyme activity ( e.g. succinate dehydrogenase - SDH ) Sensitivity of Myosin ATPase to acid and alkali These generally designate fibers as : I ( Slow oxidative, SO ) -- Low glycolytic and high oxidative presence. Low ( er ) myosin ATPase, sensitive to alkali. IIa ( Fast oxidative / glycolytic, FOG ) -- High glycolytic, oxidative and myosin ATPase presence, sensitive to acid. IIb ( Fast glycolytic, FG ) -- High glycolytic and myosin ATPase presence, sensitive to acid. Low oxidative presence. IIi -- fibers intermediate between IIa and IIb. Histochemical and Physiological types correspond as follows : S and Type I, FR and type IIa, FF and type IIb, FI and IIi. Immunohistochemical ( a more recent form of fiber typing ) Myosin Heavy Chain ( MHC ) Myosin Light Chain -- alkali ( MLC1 ) Myosin Light Chain -- regulatory ( MLC2 ) The Immunohistochemical types are as follows, with the type IIa, IIb and slow corresponding to IIa, IIb and slow ( type I ) histochemical types : Expressed in Gene family Developing Fast fibers ( II ) Slow fibers ( I ) MHC Embryonic MHC MHC IIa β / slow MHC Neonatal MHC MHC IIb MHC IIx MLC1 ( alkali ) Embryonic 1f 1s 1f 3f MLC2 ( regulatory ) 2f 2f 2s Table reproduced from Gene characterization of myosins There are currently about 15 known different types of MHC genes recognized in muscle, only some of which may be expressed in a single muscle fiber. These genes form one of ~ 18 classes of myosin genes, identified as class II which should not be confused with the type II myosins identified by immunohistochemistry. The expression of multiple MHC genes in a single muscle fiber is an example of polymorphism. The relative expression of these myosin types is determined partly by genetics and partly by other biological factors such as activity, innervation and hormones. The typing of motor units has thus gone through many stages and reached a point where it is recognized that muscle fibers contain varying mixtures of several mysosin types that can not easily be classified into specific groups of fibers. The three ( or four ) classical fiber types represent peaks in the distribution of muscle fiber properties, each determined by the overall biochemistry of the fibers. Estimates of innervation ratios of motor units in human muscles : Muscle Number of Motor Axons Number of Muscle Fibers Innervation Ratio Reference Biceps 774 580,000 750 Buchtal, 1961 Brachioradialis 315 129,000 410 Feinstein et al First dorsal interosseous 119 40,500 340 Feinstein et al Medial gastrocnemius 579 1,120,000 1,934 Feinstein et al Tibialis anterior 445 250,200 562 Feinstein et al Table reproduced from See also MYH1, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYH10, MYH11, MYH13, MYH14, MYH15, MYH16 tetanic contraction motor unit number estimation References Altshuler, Douglas ; K. Welch ; B. Cho ; D. Welch ; A. Lin ; W. Dickinson ; M. Dickinson ( April 2010 ). `` Neuromuscular control of wingbeat kinematics in Annas hummingbirds ''. The Journal of Experimental Biology. 213 : 2507 -- 2514. doi : 10.1242 / jeb. 043497. PMC 2892424. PMID 20581280. ^ Jump up to : Buchtal, F ; H. Schmalbruch ( 1 January 1980 ). `` Motor Unit of Mammalian Muscle '' ( PDF ). Physiological Reviews. 60 ( 1 ) : 90 -- 142. Retrieved 6 December 2012. Jump up ^ Kandel, Eric ( 2013 ). Principles of Neural Science, 5th ed. McGraw - Hill, New York. p. 768. ISBN 978 - 0 - 07 - 139011 - 8. Jump up ^ Milner - Brown HS, Stein RB, Yemm R ( September 1973 ). `` The orderly recruitment of human motor units during voluntary isometric contractions '' ( PDF ). J. Physiol. 230 ( 2 ) : 359 -- 70. doi : 10.1113 / jphysiol. 1973. sp010192. PMC 1350367. PMID 4350770. Jump up ^ Robinson R ( February 2009 ). `` In mammalian muscle, axonal wiring takes surprising paths ''. PLoS Biol. 7 ( 2 ) : e1000050. doi : 10.1371 / journal. pbio. 1000050. PMC 2637923. PMID 20076726. Jump up ^ Farina, Dario ; Merletti R ; Enoka R.M. ( 2004 ). `` The extraction of neural strategies from the surface EMG ''. Journal of Applied Physiology. 96 : 1486 -- 1495. doi : 10.1152 / japplphysiol. 01070.2003. Jump up ^ Spiegel KM. ; Stratton J. ; Burke JR. ; Glendinning DS ; Enoka RM ( November 2012 ). `` The influence of age on the assessment of motor unit activation in a human hand muscle ''. J. Experimental Physiology. 81 ( 5 ) : 805 -- 819. Jump up ^ De Luca, Carlo ; William J. Forrest ( December 1972 ). `` Some Properties of Motor Unit Action Potential Trains Recorded during Constant Force Isometric Contractions in Man ''. Kybernetik. 12 : 160 -- 168. doi : 10.1007 / bf00289169. ^ Jump up to : Burke RE, Levine DN, Tsairis P, Zajac FE ( November 1973 ). `` Physiological types and histochemical profiles in motor units of the cat gastrocnemius ''. J. Physiol. 234 ( 3 ) : 723 -- 48. doi : 10.1113 / jphysiol. 1973. sp010369. PMC 1350696. PMID 4148752. Jump up ^ Collatos TC, Edgerton VR, Smith JL, Botterman BR ( November 1977 ). `` Contractile properties and fiber type compositions of flexors and extensors of elbow joint in cat : implications for motor control ''. J. Neurophysiol. 40 ( 6 ) : 1292 -- 300. PMID 925731. Jump up ^ Altshuler D. ; Welch K. ; Cho B. ; Welch D. ; Lin A. ; Dickinson W. ; Dickinson M. ( April 2010 ). `` Neuromuscular control of wingbeat kinematics in Annas hummingbirds ''. J. The Journal of Experimental Biology. 213 : 2507 -- 2514. doi : 10.1242 / jeb. 043497. PMC 2892424. PMID 20581280. ^ Jump up to : Schiaffino S, Reggiani C ( August 1994 ). `` Myosin isoforms in mammalian skeletal muscle ''. J. Appl. Physiol. 77 ( 2 ) : 493 -- 501. PMID 8002492. ^ Jump up to : Caiozzo VJ, Baker MJ, Huang K, Chou H, Wu YZ, Baldwin KM ( September 2003 ). `` Single - fiber myosin heavy chain polymorphism : how many patterns and what proportions ? ''. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285 ( 3 ) : R570 -- 80. doi : 10.1152 / ajpregu. 00646.2002. PMID 12738613. Jump up ^ Baldwin KM, Haddad F ( January 2001 ). `` Effects of different activity and inactivity paradigms on myosin heavy chain gene expression in striated muscle ''. J. Appl. Physiol. 90 ( 1 ) : 345 -- 57. PMID 11133928. Jump up ^ Karpati, George ( 2010 ). Disorders of Voluntary Muscle ( PDF ). Cambridge University Press. p. 7. ISBN 9780521876292. External links Neurons and Support Cells Muscle tissue Smooth muscle Calmodulin Vascular smooth muscle Striated muscle Skeletal muscle Costamere / DAPC Membrane / extracellular DAP : Sarcoglycan SGCA SGCB SGCD SGCE SGCG SGCZ Dystroglycan Sarcospan Laminin, alpha 2 Intracellular Dystrophin Dystrobrevin Syntrophin B1 B2 G1 G2 Syncoilin Dysbindin Synemin / desmuslin related : NOS1 Caveolin 3 Sarcomere / ( a, i, and h bands ; z and m lines ) Myofilament thin filament / actin thick filament / myosin elastic filament / titin nebulin Tropomyosin Troponin Connective tissue Epimysium Fascicle Perimysium Endomysium Connective tissue in skeletal muscle General Neuromuscular junction Motor unit Muscle spindle Excitation -- contraction coupling Sliding filament mechanism Cardiac muscle Myocardium Intercalated disc Nebulette Both Fiber Muscle fiber intrafusal extrafusal Myofibril Microfilament / Myofilament Sarcomere Cells Myoblast / Myocyte Myosatellite cell Other Desmin Sarcoplasm Sarcolemma T - tubule Sarcoplasmic reticulum Other / ungrouped Myotilin Telethonin Dysferlin Fukutin Fukutin - related protein Retrieved from `` https://en.wikipedia.org/w/index.php?title=Motor_unit&oldid=824304914 '' Categories : Somatic motor system Talk Contents About Wikipedia Deutsch Español فارسی Français Italiano עברית 日本 語 Norsk Polski Português Русский Suomi Türkçe 5 more Edit links This page was last edited on 6 February 2018, at 15 : 33. 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Question: what are the muscle fibers under the control of a single motor axon
Answer: A motor unit