Human genetic variation - wikipedia Human genetic variation A graphical representation of the typical human karyotype. The human mitochondrial DNA. Human genetic variation is the genetic differences both within and among populations. There may be multiple variants of any given gene in the human population ( genes ), leading to polymorphism. Many genes are not polymorphic, meaning that only a single allele is present in the population : the gene is then said to be fixed. No two humans are genetically identical. On average, in terms of DNA sequence, each human is 99.5 % similar to any other human. Even monozygotic twins, who develop from one zygote, have infrequent genetic differences due to mutations occurring during development and gene copy - number variation. Differences between individuals, even closely related individuals, are the key to techniques such as genetic fingerprinting. Alleles occur at different frequencies in different human populations, with populations that are more geographically and ancestrally remote tending to differ more, a phenomenon known as isolation - by - distance. The differences between different populations represent a small proportion of overall human genetic variation. Populations also differ in the quantity of variation among their members, with greatest diversity among African populations. This is consistent with the theory that humans recently migrated out of Africa. Populations also vary in the ( always small ) proportion of DNA they received from archaic hominid populations, such as Neanderthals and Denisovans. The study of human genetic variation has both evolutionary significance and medical applications. It can help scientists understand ancient human population migrations as well as how different human groups are biologically related to one another. For medicine, study of human genetic variation may be important because some disease - causing alleles occur more often in people from specific geographic regions. New findings show that each human has on average 60 new mutations compared to their parents. Contents 1 Causes of variation 2 Measures of variation 2.1 Single nucleotide polymorphisms 2.2 Structural variation 2.2. 1 Copy number variation 2.3 Epigenetics 2.4 Genetic variability 2.5 Clines 2.6 Haplogroups 2.7 Variable number tandem repeats 3 History and geographic distribution 3.1 Population genetics 3.2 Distribution of variation 3.2. 1 Phenotypic variation 3.3 Archaic admixture 4 Categorization of the world population 4.1 Genetic clustering 4.2 Forensic anthropology 4.3 Gene flow and admixture 5 Health 6 Genome projects 7 See also 8 References 9 Further reading 10 External links Causes of variation Causes of differences between individuals include independent assortment, the exchange of genes ( crossing over and recombination ) during meiosis and various mutational events. There are at least two reasons why genetic variation exists between populations. Natural selection may confer an adaptive advantage to individuals in a specific environment if an allele provides a competitive advantage. Alleles under selection are likely to occur only in those geographic regions where they confer an advantage. The second main cause of genetic variation is due to the high degree of neutrality of most mutations. Most mutations do not appear to have any selective effect one way or the other on the organism. Population differences occur due to several causes, including random genetic drift, the influence of small migrant populations ( the `` founder effect '' ), and differences in selective pressures acting on human populations in different environments. The main cause is genetic drift, this is the effect of random changes in the gene pool. In humans, founder effect and past small population size ( increasing the likelihood of genetic drift ) may have had an important influence in neutral differences between populations. Measures of variation Genetic variation among humans occurs on many scales, from gross alterations in the human karyotype to single nucleotide changes. Chromosome abnormalities are detected in 1 of 160 live human births. Apart from sex chromosome disorders, most cases of aneuploidy result in death of the developing fetus ( miscarriage ) ; the most common extra autosomal chromosomes among live births are 21, 18 and 13. Nucleotide diversity is the average proportion of nucleotides that differ between two individuals. The human nucleotide diversity is estimated to be 0.1 % to 0.4 % of base pairs. A difference of 1 in 1,000 amounts to approximately 3 million nucleotide differences, because the human genome has about 3 billion nucleotides. Scientists using data from the 1000 Genomes Project, which sequenced one thousand individuals from 26 human populations, found that `` a typical ( individual ) genome differs from the reference human genome at 4.1 million to 5.0 million sites... affecting 20 million bases of sequence. '' Nearly all ( > 99.9 % ) of these sites are small differences, either single nucleotide polymorphisms or brief insertion - deletions in the genetic sequence, but structural variations account for a greater number of base - pairs than the SNPs and indels. As of 2017, the Single Nucleotide Polymorphism Database ( dbSNP ), which lists SNP and other variants, listed 324 million different variants found in sequenced human genomes. Single nucleotide polymorphisms DNA molecule 1 differs from DNA molecule 2 at a single base - pair location ( a C / T polymorphism ). Main article : Single nucleotide polymorphism A single nucleotide polymorphism ( SNP ) is difference in a single nucleotide between members of one species that occurs in at least 1 % of the population. The 2,504 individuals characterized by the 1000 Genomes Project had 84.7 million SNPs among them. SNPs are the most common type of sequence variation, estimated in 1998 to account for 90 % of all sequence variants. Other sequence variations are single base exchanges, deletions and insertions. SNPs occur on average about every 100 to 300 bases and so are the major source of heterogeneity. A functional, or non-synonymous, SNP is one that affects some factor such as gene splicing or messenger RNA, and so causes a phenotypic difference between members of the species. About 3 % to 5 % of human SNPs are functional ( see International HapMap Project ). Neutral, or synonymous SNPs are still useful as genetic markers in genome - wide association studies, because of their sheer number and the stable inheritance over generations. A coding SNP is one that occurs inside a gene. There are 105 Human Reference SNPs that result in premature stop codons in 103 genes. This corresponds to 0.5 % of coding SNPs. They occur due to segmental duplication in the genome. These SNPs result in loss of protein, yet all these SNP alleles are common and are not purified in negative selection. Structural variation Main article : Structural variation Structural variation is the variation in structure of an organism 's chromosome. Structural variations, such as copy - number variation and deletions, inversions, insertions and duplications, account for much more human genetic variation than single nucleotide diversity. This was concluded in 2007 from analysis of the diploid full sequences of the genomes of two humans : Craig Venter and James D. Watson. This added to the two haploid sequences which were amalgamations of sequences from many individuals, published by the Human Genome Project and Celera Genomics respectively. According to the 1000 Genomes Project, a typical human has 2,100 to 2,500 structural variations, which include approximately 1,000 large deletions, 160 copy - number variants, 915 Alu insertions, 128 L1 insertions, 51 SVA insertions, 4 NUMT s, and 10 inversions. Copy number variation Main article : Copy number variation A copy - number variation ( CNV ) is a difference in the genome due to deleting or duplicating large regions of DNA on some chromosome. It is estimated that 0.4 % of the genomes of unrelated humans differ with respect to copy number. When copy number variation is included, human - to - human genetic variation is estimated to be at least 0.5 % ( 99.5 % similarity ). Copy number variations are inherited but can also arise during development. A visual map with the regions with high genomic variation of the modern - human reference assembly relatively to a Neanderthal of 50k has been built by Pratas et al. Epigenetics Epigenetic variation is variation in the chemical tags that attach to DNA and affect how genes get read. The tags, `` called epigenetic markings, act as switches that control how genes can be read. '' At some alleles, the epigenetic state of the DNA, and associated phenotype, can be inherited across generations of individuals. Genetic variability Main article : Genetic variability Genetic variability is a measure of the tendency of individual genotypes in a population to vary ( become different ) from one another. Variability is different from genetic diversity, which is the amount of variation seen in a particular population. The variability of a trait is how much that trait tends to vary in response to environmental and genetic influences. Clines Main article : Cline ( biology ) In biology, a cline is a continuum of species, populations, races, varieties, or forms of organisms that exhibit gradual phenotypic and / or genetic differences over a geographical area, typically as a result of environmental heterogeneity. In the scientific study of human genetic variation, a gene cline can be rigorously defined and subjected to quantitative metrics. Haplogroups Main article : Haplogroup In the study of molecular evolution, a haplogroup is a group of similar haplotypes that share a common ancestor with a single nucleotide polymorphism ( SNP ) mutation. Haplogroups pertain to deep ancestral origins dating back thousands of years. The most commonly studied human haplogroups are Y - chromosome ( Y - DNA ) haplogroups and mitochondrial DNA ( mtDNA ) haplogroups, both of which can be used to define genetic populations. Y - DNA is passed solely along the patrilineal line, from father to son, while mtDNA is passed down the matrilineal line, from mother to both daughter and son. The Y - DNA and mtDNA may change by chance mutation at each generation. Variable number tandem repeats Main article : Variable number tandem repeat A variable number tandem repeat ( VNTR ) is the variation of length of a tandem repeat. A tandem repeat is the adjacent repetition of a short nucleotide sequence. Tandem repeats exist on many chromosomes, and their length varies between individuals. Each variant acts as an inherited allele, so they are used for personal or parental identification. Their analysis is useful in genetics and biology research, forensics, and DNA fingerprinting. Short tandem repeats ( about 5 base pairs ) are called microsatellites, while longer ones are called minisatellites. History and geographic distribution Map of the migration of modern humans out of Africa, based on mitochondrial DNA. Colored rings indicate thousand years before present. Dominant Y - chromosome haplogroups in pre-colonial world populations, with possible migrations routes according to the Coastal Migration Model. See also : Human evolutionary genetics § Modern humans The Out of Africa theory ( more precisely called `` recent African origin of modern humans '' ) is the most widely accepted explanation of the origin and early dispersal of anatomically modern humans, Homo sapiens sapiens. The theory states that archaic Homo sapiens evolved into modern humans solely in Africa, 200,000 to 100,000 years ago ; around that time, one African subpopulation of hominins among several was the subpopulation ancestral to all human beings today. Some members of that subpopulation left Africa by 60,000 years ago and over time replaced earlier hominin populations such as Homo erectus and Neanderthals. Alternative theories include the multiregional origin of modern humans hypothesis. The theory is supported by both genetic and fossil evidence. The hypothesis originated in the 19th century, with Charles Darwin 's Descent of Man, but remained speculative until the 1980s when it was supported by study of present - day mitochondrial DNA, combined with evidence from physical anthropology of archaic specimens. A large study published in 2009 found that modern humans probably originated near the border of Namibia and South Africa ( reported as Namibia and Angola by BBC ), and some left Africa through East Africa. Observations consistent with this are that Africa contains the most human genetic diversity anywhere on Earth, and the genetic structure of Africans traces to 14 ancestral population clusters that correlate with ethnicity and culture or language. The study lasted ten years and analyzed variations at 1,327 DNA markers of 121 African populations, 4 African American populations, and 60 non-African populations. According to a 2000 study of Y - chromosome sequence variation, human Y - chromosomes trace ancestry to Africa, and the descendants of the derived lineage left Africa and eventually were replaced by archaic human Y - chromosomes in Eurasia. The study also shows that a minority of contemporary East Africans and Khoisan are the descendants of the most ancestral patrilineages of anatomically modern humans that left Africa 35,000 to 89,000 years ago. Other evidence supporting the theory is that variations in skull measurements decrease with distance from Africa at the same rate as the decrease in genetic diversity. Human genetic diversity decreases in native populations with migratory distance from Africa, and this is thought to be due to bottlenecks during human migration, which are events that temporarily reduce population size. Population Genetics In the field of population genetics, it is believed that the distribution of neutral polymorphisms among contemporary humans reflects human demographic history. It has been theorized that humans passed through a population bottleneck before a rapid expansion coinciding with migrations out of Africa leading to an African - Eurasian divergence around 100,000 years ago ( ca. 3,000 generations ), followed by a European - Asian divergence about 40,000 years ago ( ca. 1,200 generations ). Richard G. Klein, Nicholas Wade and Spencer Wells, among others, have postulated that modern humans did not leave Africa and successfully colonize the rest of the world until as recently as 60,000 - 50,000 years B.P., pushing back the dates for subsequent population splits as well. The rapid expansion of a previously small population has two important effects on the distribution of genetic variation. First, the so - called founder effect occurs when founder populations bring only a subset of the genetic variation from their ancestral population. Second, as founders become more geographically separated, the probability that two individuals from different founder populations will mate becomes smaller. The effect of this assortative mating is to reduce gene flow between geographical groups, and to increase the genetic distance between groups. The expansion of humans from Africa affected the distribution of genetic variation in two other ways. First, smaller ( founder ) populations experience greater genetic drift because of increased fluctuations in neutral polymorphisms. Second, new polymorphisms that arose in one group were less likely to be transmitted to other groups as gene flow was restricted. Our history as a species also has left genetic signals in regional populations. For example, in addition to having higher levels of genetic diversity, populations in Africa tend to have lower amounts of linkage disequilibrium than do populations outside Africa, partly because of the larger size of human populations in Africa over the course of human history and partly because the number of modern humans who left Africa to colonize the rest of the world appears to have been relatively low ( Gabriel et al. 2002 ). In contrast, populations that have undergone dramatic size reductions or rapid expansions in the past and populations formed by the mixture of previously separate ancestral groups can have unusually high levels of linkage disequilibrium ( Nordborg and Tavare 2002 ). Many other geographic, climatic, and historical factors have contributed to the patterns of human genetic variation seen in the world today. For example, population processes associated with colonization, periods of geographic isolation, socially reinforced endogamy, and natural selection all have affected allele frequencies in certain populations ( Jorde et al. 2000b ; Bamshad and Wooding 2003 ). In general, however, the recency of our common ancestry and continual gene flow among human groups have limited genetic differentiation in our species. Distribution of variation The distribution of genetic variants within and among human populations are impossible to describe succinctly because of the difficulty of defining a `` population, '' the clinal nature of variation, and heterogeneity across the genome ( Long and Kittles 2003 ). In general, however, an average of 85 % of genetic variation exists within local populations, ~ 7 % is between local populations within the same continent, and ~ 8 % of variation occurs between large groups living on different continents,. ( Lewontin 1972 ; Jorde et al. 2000a ). The recent African origin theory for humans would predict that in Africa there exists a great deal more diversity than elsewhere, and that diversity should decrease the further from Africa a population is sampled. Phenotypic variation For more details on this topic, see Phenotype § Phenotypic_variation. Sub-Saharan Africa has the most human genetic diversity and the same has been shown to hold true for phenotypic diversity. Phenotype is connected to genotype through gene expression. Genetic diversity decreases smoothly with migratory distance from that region, which many scientists believe to be the origin of modern humans, and that decrease is mirrored by a decrease in phenotypic variation. Skull measurements are an example of a physical attribute whose within - population variation decreases with distance from Africa. The distribution of many physical traits resembles the distribution of genetic variation within and between human populations ( American Association of Physical Anthropologists 1996 ; Keita and Kittles 1997 ). For example, ~ 90 % of the variation in human head shapes occurs within continental groups, and ~ 10 % separates groups, with a greater variability of head shape among individuals with recent African ancestors ( Relethford 2002 ). A prominent exception to the common distribution of physical characteristics within and among groups is skin color. Approximately 10 % of the variance in skin color occurs within groups, and ~ 90 % occurs between groups ( Relethford 2002 ). This distribution of skin color and its geographic patterning -- with people whose ancestors lived predominantly near the equator having darker skin than those with ancestors who lived predominantly in higher latitudes -- indicate that this attribute has been under strong selective pressure. Darker skin appears to be strongly selected for in equatorial regions to prevent sunburn, skin cancer, the photolysis of folate, and damage to sweat glands. Understanding how genetic diversity in the human population impacts various levels of gene expression is an active area of research. While earlier studies focused on the relationship between DNA variation and RNA expression, more recent efforts are characterizing the genetic control of various aspects of gene expression including chromatin states, translation, and protein levels. A study published in 2007 found that 25 % of genes showed different levels of gene expression between populations of European and Asian descent. The primary cause of this difference in gene expression was thought to be SNPs in gene regulatory regions of DNA. Another study published in 2007 found that approximately 83 % of genes were expressed at different levels among individuals and about 17 % between populations of European and African descent. Archaic admixture Main article : Archaic human admixture with modern humans There is a hypothesis that anatomically modern humans interbred with Neanderthals during the Middle Paleolithic. In May 2010, the Neanderthal Genome Project presented genetic evidence that interbreeding did likely take place and that a small but significant portion of Neanderthal admixture is present in the DNA of modern Eurasians and Oceanians, and nearly absent in sub-Saharan African populations. Between 4 % and 6 % of the genome of Melanesians ( represented by the Papua New Guinean and Bougainville Islander ) are thought to derive from Denisova hominins - a previously unknown species which shares a common origin with Neanderthals. It was possibly introduced during the early migration of the ancestors of Melanesians into Southeast Asia. This history of interaction suggests that Denisovans once ranged widely over eastern Asia. Thus, Melanesians emerge as the most archaic - admixed population, having Denisovan / Neanderthal - related admixture of ~ 8 %. In a study published in 2013, Jeffrey Wall from University of California studied whole sequence - genome data and found higher rates of introgression in Asians compared to Europeans. Hammer et al. tested the hypothesis that contemporary African genomes have signatures of gene flow with archaic human ancestors and found evidence of archaic admixture in African genomes, suggesting that modest amounts of gene flow were widespread throughout time and space during the evolution of anatomically modern humans. Categorization of the world population Chart showing human genetic clustering. See also : Race ( human classification ) and Race and genetics New data on human genetic variation has reignited the debate about a possible biological basis for categorization of humans into races. Most of the controversy surrounds the question of how to interpret the genetic data and whether conclusions based on it are sound. Some researchers argue that self - identified race can be used as an indicator of geographic ancestry for certain health risks and medications. Although the genetic differences among human groups are relatively small, these differences in certain genes such as duffy, ABCC11, SLC24A5, called ancestry - informative markers ( AIMs ) nevertheless can be used to reliably situate many individuals within broad, geographically based groupings. For example, computer analyses of hundreds of polymorphic loci sampled in globally distributed populations have revealed the existence of genetic clustering that roughly is associated with groups that historically have occupied large continental and subcontinental regions ( Rosenberg et al. 2002 ; Bamshad et al. 2003 ). Some commentators have argued that these patterns of variation provide a biological justification for the use of traditional racial categories. They argue that the continental clusterings correspond roughly with the division of human beings into sub-Saharan Africans ; Europeans, Western Asians, Central Asians, Southern Asians and Northern Africans ; Eastern Asians, Southeast Asians, Polynesians and Native Americans ; and other inhabitants of Oceania ( Melanesians, Micronesians & Australian Aborigines ) ( Risch et al. 2002 ). Other observers disagree, saying that the same data undercut traditional notions of racial groups ( King and Motulsky 2002 ; Calafell 2003 ; Tishkoff and Kidd 2004 ). They point out, for example, that major populations considered races or subgroups within races do not necessarily form their own clusters. Furthermore, because human genetic variation is clinal, many individuals affiliate with two or more continental groups. Thus, the genetically based `` biogeographical ancestry '' assigned to any given person generally will be broadly distributed and will be accompanied by sizable uncertainties ( Pfaff et al. 2004 ). In many parts of the world, groups have mixed in such a way that many individuals have relatively recent ancestors from widely separated regions. Although genetic analyses of large numbers of loci can produce estimates of the percentage of a person 's ancestors coming from various continental populations ( Shriver et al. 2003 ; Bamshad et al. 2004 ), these estimates may assume a false distinctiveness of the parental populations, since human groups have exchanged mates from local to continental scales throughout history ( Cavalli - Sforza et al. 1994 ; Hoerder 2002 ). Even with large numbers of markers, information for estimating admixture proportions of individuals or groups is limited, and estimates typically will have wide confidence intervals ( Pfaff et al. 2004 ). Genetic clustering Main article : Human genetic clustering Genetic data can be used to infer population structure and assign individuals to groups that often correspond with their self - identified geographical ancestry. Jorde and Wooding ( 2004 ) argued that `` Analysis of many loci now yields reasonably accurate estimates of genetic similarity among individuals, rather than populations. Clustering of individuals is correlated with geographic origin or ancestry. '' An analysis of autosomal SNP data from the International HapMap Project ( Phase II ) and CEPH Human Genome Diversity Panel samples was published in 2009. The study of 53 populations taken from the HapMap and CEPH data ( 1138 unrelated individuals ) suggested that natural selection may shape the human genome much more slowly than previously thought, with factors such as migration within and among continents more heavily influencing the distribution of genetic variations. A similar study published in 2010 found strong genome - wide evidence for selection due to changes in ecoregion, diet, and subsistence particularly in connection with polar ecoregions, with foraging, and with a diet rich in roots and tubers. In a 2016 study, principal component analysis of genome - wide data was capable of recovering previously - known targets for positive selection ( without prior definition of populations ) as well as a number of new candidate genes. Forensic anthropology Forensic anthropologists can determine aspects of geographic ancestry ( i.e. Asian, African, or European ) from skeletal remains with a high degree of accuracy by analyzing skeletal measurements. According to some studies, individual test methods such as mid-facial measurements and femur traits can identify the geographic ancestry and by extension the racial category to which an individual would have been assigned during their lifetime, with over 80 % accuracy, and in combination can be even more accurate. However, the skeletons of persons who have recent ancestry in different geographical regions, can exhibit characteristics of more than one ancestral group, and hence can not be identified as belonging to any single ancestral group. Triangle plot shows average admixture of five North American ethnic groups. Individuals that self - identify with each group can be found at many locations on the map, but on average groups tend to cluster differently. Gene flow and admixture Main article : Gene flow Gene flow between two populations reduces the average genetic distance between the populations, only totally isolated human populations experience no gene flow and most populations have continuous gene flow with other neighboring populations which create the clinal distribution observed for moth genetic variation. When gene flow takes place between well - differentiated genetic populations the result is referred to as `` genetic admixture ''. Admixture mapping is a technique used to study how genetic variants cause differences in disease rates between population. Recent admixture populations that trace their ancestry to multiple continents are well suited for identifying genes for traits and diseases that differ in prevalence between parental populations. African - American populations have been the focus of numerous population genetic and admixture mapping studies, including studies of complex genetic traits such as white cell count, body - mass index, prostate cancer and renal disease. An analysis of phenotypic and genetic variation including skin color and socio - economic status was carried out in the population of Cape Verde which has a well documented history of contact between Europeans and Africans. The studies showed that pattern of admixture in this population has been sex - biased and there is a significant interactions between socio economic status and skin color independent of the skin color and ancestry. Another study shows an increased risk of graft - versus - host disease complications after transplantation due to genetic variants in human leukocyte antigen ( HLA ) and non-HLA proteins. Health See also : Race and health Differences in allele frequencies contribute to group differences in the incidence of some monogenic diseases, and they may contribute to differences in the incidence of some common diseases ( Risch et al. 2002 ; Burchard et al. 2003 ; Tate and Goldstein 2004 ). For the monogenic diseases, the frequency of causative alleles usually correlates best with ancestry, whether familial ( for example, Ellis - van Creveld syndrome among the Pennsylvania Amish ), ethnic ( Tay - Sachs disease among Ashkenazi Jewish populations ), or geographical ( hemoglobinopathies among people with ancestors who lived in malarial regions ). To the extent that ancestry corresponds with racial or ethnic groups or subgroups, the incidence of monogenic diseases can differ between groups categorized by race or ethnicity, and health - care professionals typically take these patterns into account in making diagnoses. Even with common diseases involving numerous genetic variants and environmental factors, investigators point to evidence suggesting the involvement of differentially distributed alleles with small to moderate effects. Frequently cited examples include hypertension ( Douglas et al. 1996 ), diabetes ( Gower et al. 2003 ), obesity ( Fernandez et al. 2003 ), and prostate cancer ( Platz et al. 2000 ). However, in none of these cases has allelic variation in a susceptibility gene been shown to account for a significant fraction of the difference in disease prevalence among groups, and the role of genetic factors in generating these differences remains uncertain ( Mountain and Risch 2004 ). Apart from mutations, many genes that may have aided humans in ancient times plague humans today. For example, it is suspected that genes that allow humans to more efficiently process food are those that make people susceptible to obesity and diabetes today. Neil Risch of Stanford University has proposed that self - identified race / ethnic group could be a valid means of categorization in the USA for public health and policy considerations. A 2002 paper by Noah Rosenberg 's group makes a similar claim : `` The structure of human populations is relevant in various epidemiological contexts. As a result of variation in frequencies of both genetic and nongenetic risk factors, rates of disease and of such phenotypes as adverse drug response vary across populations. Further, information about a patient 's population of origin might provide health care practitioners with information about risk when direct causes of disease are unknown. '' Genome projects For more details on this topic, see Category : Human genome projects. Human genome projects are scientific endeavors that determine or study the structure of the human genome. The Human Genome Project was a landmark genome project. See also Race and genetics Archaeogenetics Human evolutionary genetics Multiregional hypothesis Recent single origin hypothesis Isolation by distance Genealogical DNA test Y - chromosome haplogroups in populations of the world Human genetic clustering Regional : Genetic history of Europe Genetic history of South Asia African admixture in Europe Genetic history of indigenous peoples of the Americas Genetic history of the British Isles Projects : 1000 Genomes Project Human Variome Project References Jump up ^ When all genes are fixed within a population, so every member of the population is genetically identical, the population is said to be clonal. This occurs in species that reproduce asexually. Jump up ^ Dr. Craig Venter, Aaron. `` In the Genome Race, the Sequel Is Personal ''. Jump up ^ Samuel Levy ; Granger Sutton ; Pauline C Ng ; Lars Feuk ; Aaron L Halpern ; Brian P Walenz ; Nelson Axelrod ; Jiaqi Huang ; Ewen F Kirkness ; Gennady Denisov ; Yuan Lin ; Jeffrey R MacDonald ; Andy Wing Chun Pang ; Mary Shago ; Timothy B Stockwell ; Alexia Tsiamouri ; Vineet Bafna ; Vikas Bansal ; Saul A Kravitz ; Dana A Busam ; Karen Y Beeson ; Tina C McIntosh ; Karin A Remington ; Josep F Abril ; John Gill ; Jon Borman ; Yu - Hui Rogers ; Marvin E Frazier ; Stephen W Scherer ; Robert L Strausberg ; J. Craig Venter ( 4 September 2007 ). `` The Diploid Genome Sequence of an Individual Human ''. PLOS Biology. Public Library of Science. p. Author Summary. doi : 10.1371 / journal. pbio. 0050254. Retrieved 21 March 2016. Jump up ^ Bruder, CEG ; et al. ( 2008 ). `` Phenotypically Concordant and Discordant Monozygotic Twins Display Different DNA Copy - Number - Variation Profiles ''. The American Journal of Human Genetics. 82 ( 3 ) : 763 -- 771. doi : 10.1016 / j. ajhg. 2007.12. 011. Jump up ^ `` We are all mutants : First direct whole - genome measure of human mutation predicts 60 new mutations in each of us ''. Science Daily. 13 June 2011. Retrieved 2011 - 09 - 05. Jump up ^ Conrad, DF ; et al. ( 2011 ). `` Variation in genome - wide mutation rates within and between human families ''. Nature Genetics. 43 ( 7 ) : 712 -- 4. doi : 10.1038 / ng. 862. PMC 3322360. PMID 21666693. Jump up ^ Kidd, JM ; et al. ( 2008 ). `` Mapping and sequencing of structural variation from eight human genomes ''. Nature. 453 ( 7191 ) : 56 -- 64. Bibcode : 2008Natur. 453... 56K. doi : 10.1038 / nature06862. PMC 2424287. PMID 18451855. Jump up ^ Driscoll DA, Gross S ( June 2009 ). `` Clinical practice. Prenatal screening for aneuploidy ''. The New England Journal of Medicine. 360 ( 24 ) : 2556 -- 62. doi : 10.1056 / NEJMcp0900134. PMID 19516035. ^ Jump up to : Jorde, LB ; Wooding, SP ( 2004 ). `` Genetic variation, classification and ' race ' ''. Nature Genetics. 36 ( 11s ) : S28 -- 33. doi : 10.1038 / ng1435. PMID 15508000. ^ Jump up to : Tishkoff, SA ; Kidd, KK ( 2004 ). `` Implications of biogeography of human populations for ' race ' and medicine ''. Nature Genetics. 36 ( 11s ) : S21 -- 7. doi : 10.1038 / ng1438. PMID 15507999. ^ Jump up to : The 1000 Genomes Project Consortium ( 2015 - 10 - 01 ). `` A global reference for human genetic variation ''. Nature. 526 ( 7571 ) : 68 -- 74. doi : 10.1038 / nature15393. ISSN 0028 - 0836. PMC 4750478. PMID 26432245. Jump up ^ NCBI ( 2017 - 05 - 08 ). `` dbSNP 's human build 150 has doubled the amount of RefSNP records ! ''. NCBI Insights. Retrieved 2017 - 05 - 16. ^ Jump up to : Collins, F.S. ; Brooks, L.D. ; Chakravarti, A. ( 1998 ). `` A DNA polymorphism discovery resource for research on human genetic variation ''. Genome Research. 8 ( 12 ) : 1229 -- 1231. doi : 10.1101 / gr. 8.12. 1229. PMID 9872978. Jump up ^ Thomas, P.E. ; Klinger, R. ; Furlong, L.I. ; Hofmann - Apitius, M. ; Friedrich, C.M. ( 2011 ). `` Challenges in the association of human single nucleotide polymorphism mentions with unique database identifiers ''. BMC Bioinformatics. 12 : S4. doi : 10.1186 / 1471 - 2105 - 12 - S4 - S4. PMC 3194196. PMID 21992066. Jump up ^ Ke, X ; Taylor, M.S. ; Cardon, L.R. ( 2008 ). `` Singleton SNPs in the human genome and implications for genome - wide association studies ''. European Journal of Human Genetics. 16 ( 4 ) : 506 -- 15. doi : 10.1038 / sj. ejhg. 5201987. PMID 18197193. Jump up ^ Ng, P.C. ; Levy, S. ; Huang, J. ; Stockwell, T.B. ; Walenz, B.P. ; Li, K. ; Axelrod, N. ; Busam, D.A. ; Strausberg, R.L. ; Venter, J.C. ( 2008 ). Schork, Nicholas J, ed. `` Genetic Variation in an Individual Human Exome ''. PLoS Genetics. 4 ( 8 ) : e1000160. doi : 10.1371 / journal. pgen. 1000160. PMC 2493042. PMID 18704161. Jump up ^ Gross, L ( 2007 ). `` A New Human Genome Sequence Paves the Way for Individualized Genomics ''. PLoS Biology. 5 ( 10 ) : e266. doi : 10.1371 / journal. pbio. 0050266. PMC 1964778. PMID 20076646. Jump up ^ `` First Individual Diploid Human Genome Published By Researchers at J. Craig Venter Institute ''. J. Craig Venter Institute. 3 September 2007. Retrieved 2011 - 09 - 05. Jump up ^ Levy, S ; et al. ( 2007 ). `` The Diploid Genome Sequence of an Individual Human ''. PLoS Biology. 5 ( 10 ) : e254. doi : 10.1371 / journal. pbio. 0050254. PMC 1964779. PMID 17803354. Jump up ^ `` Understanding Genetics : Human Health and the Genome ''. The Tech Museum of Innovation. 24 January 2008. Retrieved 2011 - 09 - 05. Jump up ^ `` First Diploid Human Genome Sequence Shows We 're Surprisingly Different ''. Science Daily. 4 September 2007. Retrieved 2011 - 09 - 05. Jump up ^ `` Copy number variation may stem from replication misstep ''. EurekAlert !. 27 December 2007. Retrieved 2011 - 09 - 05. Jump up ^ Lee, JA ; Carvalho, CMB ; Lupski, JR ( 2007 ). `` A DNA Replication Mechanism for Generating Nonrecurrent Rearrangements Associated with Genomic Disorders ''. Cell. 131 ( 7 ) : 1235 -- 47. doi : 10.1016 / j. cell. 2007.11. 037. PMID 18160035. Jump up ^ Redon, R ; et al. ( 2006 ). `` Global variation in copy number in the human genome ''. Nature. 444 ( 7118 ) : 444 -- 54. Bibcode : 2006Natur. 444... 444R. doi : 10.1038 / nature05329. PMC 2669898. PMID 17122850. Jump up ^ Dumas, L ; et al. ( 2007 ). `` Gene copy number variation spanning 60 million years of human and primate evolution ''. Genome Research. 17 ( 9 ) : 1266 -- 77. doi : 10.1101 / gr. 6557307. PMC 1950895. PMID 17666543. Jump up ^ K. Prüfer ; et.al. ( 2014 ). `` The complete genome sequence of a Neanderthal from the Altai Mountains ''. Nature. 505 : 43 -- 49. doi : 10.1038 / nature12886. PMC 4031459. PMID 24352235. Jump up ^ Pratas, D ; Hosseini, M ; Silva, R ; Pinho, A ; Ferreira, P ( June 20 -- 23, 2017 ). `` Visualization of Distinct DNA Regions of the Modern Human Relatively to a Neanderthal Genome ''. Iberian Conference on Pattern Recognition and Image Analysis. Springer : 235 -- 242. Jump up ^ `` Human Genetic Variation Fact Sheet ''. National Institute of General Medical Sciences. 19 August 2011. Retrieved 2011 - 09 - 05. Jump up ^ Rakyan, V ; Whitelaw, E ( 2003 ). `` Transgenerational epigenetic inheritance ''. Current Biology. 13 ( 1 ) : R6. doi : 10.1016 / S0960 - 9822 ( 02 ) 01377 - 5. PMID 12526754. Jump up ^ `` Cline ''. Microsoft Encarta Premium. 2009. Jump up ^ King, RC ; Stansfield, WD ; Mulligan, PK ( 2006 ). `` Cline ''. A dictionary of genetics ( 7th ed. ). Oxford University Press. ISBN 978 - 0195307610. Jump up ^ Begon, M ; Townsend, CR ; Harper, JL ( 2006 ). Ecology : From individuals to ecosystems ( 4th ed. ). Wiley - Blackwell. p. 10. ISBN 978 - 1405111171. Jump up ^ `` Haplogroup ''. DNA - Newbie Glossary. International Society of Genetic Genealogy. Retrieved 2012 - 09 - 05. Jump up ^ Gill, V ( 1 May 2009 ). `` Africa 's genetic secrets unlocked ''. BBC World News. Retrieved 2012 - 09 - 05. Jump up ^ `` African Genetics Study Revealing Origins, Migration And ' Startling Diversity ' Of African Peoples ''. Science Daily. 2 May 2009. Retrieved 2011 - 09 - 05. Jump up ^ Tishkoff, SA ; et al. ( 2009 ). `` The Genetic Structure and History of Africans and African Americans ''. Science. 324 ( 5930 ) : 1035 -- 44. Bibcode : 2009Sci... 324.1035 T. doi : 10.1126 / science. 1172257. PMC 2947357. PMID 19407144. ^ Jump up to : Underhill, P.A. ; Shen, P. ; Lin, A.A. ; Jin, L. ; Passarino, G. ; Yang, W.H. ; Kauffman, E. ; Bonné - Tamir, B. ; Bertranpetit, J. ; Francalacci, P. ; Ibrahim, M. ; Jenkins, T. ; Kidd, J.R. ; Mehdi, S.Q. ; Seielstad, M.T. ; Wells, R.S. ; Piazza, A. ; Davis, R.W. ; Feldman, M.W. ; Cavalli - Sforza, L.L. ; Oefner, P.J. ( 2000 ). `` Y chromosome sequence variation and the history of human populations ''. Nature Genetics. 26 ( 3 ) : 358 -- 361. doi : 10.1038 / 81685. PMID 11062480. ^ Jump up to : `` New Research Proves Single Origin Of Humans In Africa ''. Science Daily. 19 July 2007. Retrieved 2011 - 09 - 05. Jump up ^ Manica, A ; Amos, W ; Balloux, F ; Hanihara, T ( 2007 ). `` The effect of ancient population bottlenecks on human phenotypic variation ''. Nature. 448 ( 7151 ) : 346 -- 8. Bibcode : 2007Natur. 448... 346M. doi : 10.1038 / nature05951. PMC 1978547. PMID 17637668. Jump up ^ Jablonski, Nina G. ( 10 January 2014 ). Living Color : The Biological and Social Meaning of Skin Color. University of California Press. ISBN 978 - 0 - 520 - 28386 - 2. JSTOR 10.1525 / j. ctt1pn64b. Lay summary ( 12 July 2015 ). Jump up ^ Grubert F, Zaugg JB, Kasowski M, Ursu O, Spacek DV, Martin AR, Greenside P, Srivas R, Phanstiel DH, Pekowska A, Heidari N, Euskirchen G, Huber W, Pritchard JK, Bustamante CD, Steinmetz LM, Kundaje A, Snyder M ( 2015 ). `` Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions ''. Cell. 162 ( 5 ) : 1051 -- 65. doi : 10.1016 / j. cell. 2015.07. 048. PMID 26300125. Jump up ^ Cenik C, Cenik ES, Byeon GW, Grubert F, Candille SI, Spacek D, Alsallakh B, Tilgner H, Araya CL, Tang H, Ricci E, Snyder MP ( 2015 ). `` Integrative analysis of RNA, translation, and protein levels reveals distinct regulatory variation across humans ''. Genome Res. 25 : 1610 -- 21. doi : 10.1101 / gr. 193342.115. PMC 4617958. PMID 26297486. Jump up ^ Wu L, Candille SI, Choi Y, Xie D, Jiang L, Li - Pook - Than J, Tang H, Snyder M ( 2013 ). `` Variation and genetic control of protein abundance in humans ''. Nature. 499 ( 7456 ) : 79 -- 82. doi : 10.1038 / nature12223. PMC 3789121. PMID 23676674. Jump up ^ Phillips, ML ( 9 January 2007 ). `` Ethnicity tied to gene expression ''. The Scientist. Retrieved 2011 - 09 - 05. Jump up ^ Spielman, RS ; et al. ( 2007 ). `` Common genetic variants account for differences in gene expression among ethnic groups ''. Nature Genetics. 39 ( 2 ) : 226 -- 31. doi : 10.1038 / ng1955. PMC 3005333. PMID 17206142. Jump up ^ Swaminathan, N ( 9 January 2007 ). `` Ethnic Differences Traced to Variable Gene Expression ''. Scientific American. Retrieved 2011 - 09 - 05. Jump up ^ Check, E ( 2007 ). `` Genetic expression speaks as loudly as gene type ''. Nature News. doi : 10.1038 / news070101 - 8. Jump up ^ Bell, L ( 15 January 2007 ). `` Variable gene expression seen in different ethnic groups ''. BioNews.org. Retrieved 2011 - 09 - 05. Jump up ^ Kamrani, K ( 28 February 2008 ). `` Differences of gene expression between human populations ''. Anthropology.net. Retrieved 2011 - 09 - 05. Jump up ^ Storey, JD ; et al. ( 2007 ). `` Gene - Expression Variation Within and Among Human Populations ''. The American Journal of Human Genetics. 80 ( 3 ) : 502 -- 509. doi : 10.1086 / 512017. ^ Jump up to : Reich, D ; et al. ( 2010 ). `` Genetic history of an archaic hominin group from Denisova Cave in Siberia ''. Nature. 468 ( 7327 ) : 1053 -- 60. Bibcode : 2010Natur. 468.1053 R. doi : 10.1038 / nature09710. PMID 21179161. Jump up ^ Wall, Jeffrey D. ; et al. ( 2013 ). `` Higher Levels of Neanderthal Ancestry in East Asians Than in Europeans ''. Genetics. 194 : 199 -- 209. doi : 10.1534 / genetics. 112.148213. Jump up ^ Hammer, Michael F. ; et al. ( 2011 ). `` Genetic evidence for archaic admixture in Africa ''. Proceedings of the National Academy of Sciences. 108 ( 37 ) : 15123 -- 15128. Bibcode : 2011PNAS... 10815123H. doi : 10.1073 / pnas. 1109300108. PMC 3174671. PMID 21896735. Jump up ^ Coop G, Pickrell, Novembre, Kudaravalli, Li, Absher, Myers, Cavalli - Sforza, Feldman, Pritchard ( June 2009 ). Schierup MH, ed. `` The role of geography in human adaptation ''. PLoS Genet. 5 ( 6 ) : e1000500. doi : 10.1371 / journal. pgen. 1000500. PMC 2685456. PMID 19503611. See also : Brown, David ( 22 June 2009 ). `` Among Many Peoples, Little Genomic Variety ''. The Washington Post. Retrieved 25 June 2009... `` Geography And History Shape Genetic Differences In Humans ''. Science Daily. 7 June 2009. Retrieved 25 June 2009... Jump up ^ Hancock ; et al. ( 2010 ). `` Human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency ''. PNAS. 107 : 8924 -- 8930. doi : 10.1073 / pnas. 0914625107. CS1 maint : Explicit use of et al. ( link ) Jump up ^ Duforet - Frebourg ; et al. ( 2016 ). `` Detecting Genomic Signatures of Natural Selection with Principal Component Analysis : Application to the 1000 Genomes Data ''. Mol Biol Evol. 33 ( 4 ) : 1082 -- 1093. doi : 10.1093 / molbev / msv334. CS1 maint : Explicit use of et al. ( link ) Jump up ^ `` Does Race Exist ? ''. NOVA. PBS. 15 February 2000. Retrieved 2011 - 09 - 05. Jump up ^ Winkler, C.A. ; Nelson, G.W. ; Smith, M.W. ( 2010 ). `` Admixture mapping comes of age ''. Annu Rev Genomics Hum Genet. 11 : 65 -- 89. doi : 10.1146 / annurev - genom - 082509 - 141523. PMID 20594047. Jump up ^ Bryc, K. ; Auton, A. ; Nelson, M.R. ; Oksenberg, J.R. ; Hauser, S.L. ; Williams, S. ; Froment, A. ; Bodo, J. - M. ; Wambebe, C. ; Tishkoff, S.A. ; Bustamante, C.D. ( 2009 ). `` Genome - wide patterns of population structure and admixture in West Africans and African Americans ''. Proceedings of the National Academy of Sciences. 107 ( 2 ) : 786 -- 791. Bibcode : 2010PNAS... 107... 786B. doi : 10.1073 / pnas. 0909559107. PMC 2818934. PMID 20080753. Jump up ^ Beleza, S ; Campos, J ; Lopes, J ; Araújo, I.I. ; Hoppfer Almada, A ; Correia e Silva, A ; Parra, E.J. ; Rocha, J ( 2012 ). `` The admixture structure and genetic variation of the archipelago of Cape Verde and its implications for admixture mapping studies ''. PLoS ONE. 7 ( 11 ) : e51103. doi : 10.1371 / journal. pone. 0051103. PMC 3511383. PMID 23226471. Jump up ^ Arrieta - Bolaños, E ; Madrigal, J.A. ; Shaw, B.E. ( 2012 ). `` Human leukocyte antigen profiles of latin american populations : Differential admixture and its potential impact on hematopoietic stem cell transplantation ''. Bone Marrow Research. 2012 : 136087. doi : 10.1155 / 2012 / 136087. PMC 3506882. PMID 23213535. Jump up ^ Lu, YF ; Goldstein, DB ; Angrist, M ; Cavalleri, G ( 24 July 2014 ). `` Personalized medicine and human genetic diversity ''. Cold Spring Harbor perspectives in medicine. 4 ( 9 ) : a008581. doi : 10.1101 / cshperspect. a008581. PMC 4143101. PMID 25059740. Jump up ^ Tishkoff, S.A., & Verrelli, B.C. ( 2003 ). `` PATTERNS OF HUMAN GENETIC DIVERSITY : Implications for human evolutionary history and disease ''. Annual Review of Genomics and Human Genetics. 4 ( 1 ). CS1 maint : Multiple names : authors list ( link ) Jump up ^ Tang, H ; et al. ( 2005 ). `` Genetic Structure, Self - Identified Race / Ethnicity, and Confounding in Case - Control Association Studies ''. The American Journal of Human Genetics. 76 ( 2 ) : 268 -- 75. doi : 10.1086 / 427888. PMC 1196372. PMID 15625622. Jump up ^ Risch, N ; Burchard, E ; Ziv, E ; Tang, H ( 2002 ). `` Categorization of humans in biomedical research : genes, race and disease ''. Genome Biology. 3 ( 7 ) : 1 -- 12. doi : 10.1186 / gb - 2002 - 3 - 7 - comment2007. PMC 139378. PMID 12184798. Jump up ^ Rosenberg, NA ; et al. ( 2002 ). `` Genetic Structure of Human Populations ''. Science. 298 ( 5602 ) : 2381 -- 5. Bibcode : 2002Sci... 298.2381 R. doi : 10.1126 / science. 1078311. PMID 12493913. Bibliography Race, Ethnicity ; Genetics Working Group ( 2005 ). `` The Use of Racial, Ethnic, and Ancestral Categories in Human Genetics Research ''. The American Journal of Human Genetics. 77 ( 4 ) : 519 -- 32. doi : 10.1086 / 491747. PMC 1275602. PMID 16175499. Altmüller, J ; Palmer, L ; Fischer, G ; Scherb, H ; Wjst, M ( 2001 ). `` Genomewide Scans of Complex Human Diseases : True Linkage is Hard to Find ''. The American Journal of Human Genetics. 69 ( 5 ) : 936 -- 50. doi : 10.1086 / 324069. PMC 1274370. PMID 11565063. Aoki, K ( 2002 ). `` Sexual selection as a cause of human skin colour variation : Darwin 's hypothesis revisited ''. Annals of Human Biology. 29 ( 6 ) : 589 -- 608. doi : 10.1080 / 0301446021000019144. PMID 12573076. Bamshad, M ; Wooding, S ; Salisbury, BA ; Stephens, JC ( 2004 ). `` Deconstructing the relationship between genetics and race ''. Nature Reviews Genetics. 5 ( 8 ) : 598 -- 609. doi : 10.1038 / nrg1401. PMID 15266342. reprint - zip Bamshad, M ; Wooding, SP ( 2003 ). `` Signatures of natural selection in the human genome ''. Nature Reviews Genetics. 4 ( 2 ) : 99 -- 111. doi : 10.1038 / nrg999. PMID 12560807. Bamshad, MJ ; et al. ( 2003 ). `` Human Population Genetic Structure and Inference of Group Membership ''. The American Journal of Human Genetics. 72 ( 3 ) : 578 -- 89. doi : 10.1086 / 368061. PMC 1180234. PMID 12557124. Cann, RL ; Stoneking, M ; Wilson, AC ( 1987 ). `` Mitochondrial DNA and human evolution ''. Nature. 325 ( 6099 ) : 31 -- 6. Bibcode : 1987Natur. 325... 31C. doi : 10.1038 / 325031a0. PMID 3025745. Cardon, LR ; Abecasis, GR ( 2003 ). `` Using haplotype blocks to map human complex trait loci ''. Trends in Genetics. 19 ( 3 ) : 135 -- 40. doi : 10.1016 / S0168 - 9525 ( 03 ) 00022 - 2. PMID 12615007. Cavalli - Sforza, LL ; Feldman, MW ( 2003 ). `` The application of molecular genetic approaches to the study of human evolution ''. Nature Genetics. 33 ( 3s ) : 266 -- 75. doi : 10.1038 / ng1113. PMID 12610536. Collins, FS ( 2004 ). `` What we do and do n't know about ' race ', ' ethnicity ', genetics and health at the dawn of the genome era ''. Nature Genetics. 36 ( 11s ) : S13 -- 5. doi : 10.1038 / ng1436. PMID 15507997. Collins, FS ; Green, ED ; Guttmacher, AE ; Guyer, MS ( 2003 ). `` A vision for the future of genomics research ''. Nature. 422 ( 6934 ) : 835 -- 47. Bibcode : 2003Natur. 422... 835C. doi : 10.1038 / nature01626. PMID 12695777. Ebersberger, I ; Metzler, D ; Schwarz, C ; Pääbo, S ( 2002 ). `` Genomewide Comparison of DNA Sequences between Humans and Chimpanzees ''. The American Journal of Human Genetics. 70 ( 6 ) : 1490 -- 7. doi : 10.1086 / 340787. PMC 379137. PMID 11992255. Edwards, AWF ( 2003 ). `` Human genetic diversity : Lewontin 's fallacy ''. BioEssays. 25 ( 8 ) : 798 -- 801. doi : 10.1002 / bies. 10315. PMID 12879450. Foster, MW ; Sharp, RR ( 2004 ). `` Opinion : Beyond race : Towards a whole - genome perspective on human populations and genetic variation ''. Nature Reviews Genetics. 5 ( 10 ) : 790 -- 6. doi : 10.1038 / nrg1452. PMID 15510170. Foster, M ; et al. ( 1999 ). `` The Role of Community Review in Evaluating the Risks of Human Genetic Variation Research ''. The American Journal of Human Genetics. 64 ( 6 ) : 1719 -- 27. doi : 10.1086 / 302415. PMC 1377916. PMID 10330360. Gabriel, SB ; et al. ( 2002 ). `` The Structure of Haplotype Blocks in the Human Genome ''. Science. 296 ( 5576 ) : 2225 -- 9. Bibcode : 2002Sci... 296.2225 G. doi : 10.1126 / science. 1069424. PMID 12029063. Harding, RM ; et al. ( 2000 ). `` Evidence for Variable Selective Pressures at MC1R ''. The American Journal of Human Genetics. 66 ( 4 ) : 1351 -- 61. doi : 10.1086 / 302863. PMC 1288200. PMID 10733465. Gyllensten, U ; Ingman, M ; Kaessmann, H ; Pääbo, S ( 2000 ). `` Mitochondrial genome variation and the origin of modern humans ''. Nature. 408 ( 6813 ) : 708 -- 13. doi : 10.1038 / 35047064. PMID 11130070. The International Hapmap Consortium ( 2003 ). `` The International HapMap Project ''. Nature. 426 ( 6968 ) : 789 -- 96. doi : 10.1038 / nature02168. PMID 14685227. The International Hapmap Consortium ( 2004 ). `` Opinion : Integrating ethics and science in the International HapMap Project ''. Nature Reviews Genetics. 5 ( 6 ) : 467 -- 75. doi : 10.1038 / nrg1351. PMC 2271136. PMID 15153999. The International Human Genome Sequencing Consortium ( 2001 ). `` Initial sequencing and analysis of the human genome ''. Nature. 409 ( 6822 ) : 860 -- 921. doi : 10.1038 / 35057062. PMID 11237011. Jorde, LB ; Bamshad, M ; Rogers, AR ( 1998 ). `` Using mitochondrial and nuclear DNA markers to reconstruct human evolution '' ( PDF ). BioEssays. 20 ( 2 ) : 126 -- 36. doi : 10.1002 / ( SICI ) 1521 - 1878 ( 199802 ) 20 : 2 < 126 : : AID - BIES5 > 3.0.CO ; 2 - R. PMID 9631658. Jorde, LB ; et al. ( 2000 ). `` The Distribution of Human Genetic Diversity : A Comparison of Mitochondrial, Autosomal, and Y - Chromosome Data ''. The American Journal of Human Genetics. 66 ( 3 ) : 979 -- 88. doi : 10.1086 / 302825. PMC 1288178. PMID 10712212. Jorde, LB ; Watkins, WW ; Kere, J ; Nyman, D ; Eriksson, AW ( 2000 ). `` Gene Mapping in Isolated Populations : New Roles for Old Friends ? ''. Human Heredity. 50 ( 1 ) : 57 -- 65. doi : 10.1159 / 000022891. PMID 10545758. Kaessmann, H ; Heißig, D ; von Haeseler, A ; Pääbo, S ( 1999 ). `` DNA sequence variation in a non-coding region of low recombination on the human X chromosome ''. Nature Genetics. 22 ( 1 ) : 78 -- 81. doi : 10.1038 / 8785. PMID 10319866. Kaessmann, H ; Wiebe, V ; Weiss, G ; Pääbo, S ( 2001 ). `` Great ape DNA sequences reveal a reduced diversity and an expansion in humans ''. Nature Genetics. 27 ( 2 ) : 155 -- 6. doi : 10.1038 / 84773. PMID 11175781. Keita, SOY ; Kittles, RA ( 1997 ). `` The Persistence of Racial Thinking and the Myth of Racial Divergence ''. American Anthropologist. 99 ( 3 ) : 534 -- 544. doi : 10.1525 / aa. 1997.99. 3.534. Lewontin, RC ( 1972 ). `` The apportionment of human diversity ''. Evolutionary Biology. 6 : 381 -- 398. doi : 10.1007 / 978 - 1 - 4684 - 9063 - 3_14. ISBN 978 - 1 - 4684 - 9065 - 7. Marks, J ( 1995 ). Human Biodiversity : Genes, Race, and History. Aldine Transaction. ISBN 978 - 0 - 202 - 02033 - 4. Mountain, JL ; Risch, N ( 2004 ). `` Assessing genetic contributions to phenotypic differences among ' racial ' and ' ethnic ' groups ''. Nature Genetics. 36 ( 11s ) : S48. doi : 10.1038 / ng1456. PMID 15508003. Pääbo, S ( 2003 ). `` The mosaic that is our genome ''. Nature. 421 ( 6921 ) : 409 -- 12. Bibcode : 2003Natur. 421... 409P. doi : 10.1038 / nature01400. PMID 12540910. Ramachandran, S ; et al. ( 2005 ). `` Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa ''. Proceedings of the National Academy of Sciences. 102 ( 44 ) : 15942 -- 7. Bibcode : 2005PNAS... 10215942R. doi : 10.1073 / pnas. 0507611102. PMC 1276087. PMID 16243969. Relethford, JH ( 2002 ). `` Apportionment of global human genetic diversity based on craniometrics and skin color ''. American Journal of Physical Anthropology. 118 ( 4 ) : 393 -- 8. doi : 10.1002 / ajpa. 10079. PMID 12124919. Sankar, P ; Cho, MK ( 2002 ). `` Toward a New Vocabulary of Human Genetic Variation ''. Science. 298 ( 5597 ) : 1337 -- 8. doi : 10.1126 / science. 1074447. PMC 2271140. PMID 12434037. Sankar, P ; et al. ( 2004 ). `` Genetic Research and Health Disparities ''. JAMA : the Journal of the American Medical Association. 291 ( 24 ) : 2985 -- 9. doi : 10.1001 / jama. 291.24. 2985. PMC 2271142. PMID 15213210. Serre, D ; Pääbo, S ( 2004 ). `` Evidence for Gradients of Human Genetic Diversity Within and Among Continents ''. Genome Research. 14 ( 9 ) : 1679 -- 85. doi : 10.1101 / gr. 2529604. PMC 515312. PMID 15342553. Templeton, AR ( 1998 ). `` Human Races : A Genetic and Evolutionary Perspective ''. American Anthropologist. 100 ( 3 ) : 632 -- 650. doi : 10.1525 / aa. 1998.100. 3.632. Weiss, KM ( 1998 ). `` Coming to Terms with Human Variation ''. Annual Review of Anthropology. 27 : 273 -- 300. doi : 10.1146 / annurev. anthro. 27.1. 273. Weiss, KM ; Terwilliger, JD ( 2000 ). `` How many diseases does it take to map a gene with SNPs ? ''. Nature Genetics. 26 ( 2 ) : 151 -- 7. doi : 10.1038 / 79866. PMID 11017069. Yu, N ; et al. ( 2003 ). `` Low nucleotide diversity in chimpanzees and bonobos ''. Genetics. 164 ( 4 ) : 1511 -- 8. PMC 1462640. PMID 12930756. Ziętkiewicz, E ; et al. ( 2003 ). `` Haplotypes in the Dystrophin DNA Segment Point to a Mosaic Origin of Modern Human Diversity ''. The American Journal of Human Genetics. 73 ( 5 ) : 994 -- 1015. doi : 10.1086 / 378777. PMC 1180505. PMID 14513410. Further reading Pennisi, E ( 2007 ). `` Breakthrough of the Year : Human Genetic Variation ''. Science. 318 ( 5858 ) : 1842 -- 1843. doi : 10.1126 / science. 318.5858. 1842. PMID 18096770. Ramachandran, S ; Tang, H ; Gutenkunst, RN ; Bustamante, CD ( 2010 ). `` Genetics and Genomics of Human Population Structure ''. In Speicher, MR ; Antonarakis, SE ; Motulsky, AG. Vogel and Motulsky 's Human Genetics : Problems and Approaches ( 4th ed. ). Springer. ISBN 3 - 540 - 37653 - 4. External links Wikimedia Commons has media related to Human genetic diversity. 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Question: where do we find the highest genetic diversity among human populations
Answer: Africa