Salivary gland - wikipedia Salivary gland Salivary gland Human salivary glands. Details System Digestive system Identifiers Latin Glandulae salivariae MeSH D012469 FMA 95971 Anatomical terminology ( edit on Wikidata ) The salivary glands in mammals are exocrine glands that produce saliva through a system of ducts. Humans have three paired major salivary glands ( parotid, submandibular, and sublingual ) as well as hundreds of minor salivary glands. Salivary glands can be classified as serous, mucous or seromucous ( mixed ). In serous secretions, the main type of protein secreted is alpha - amylase, an enzyme that breaks down starch into maltose and glucose, whereas in mucous secretions the main protein secreted is mucin, which acts as a lubricant. In humans, between 0.5 and 1.5 litres of saliva are produced every day. The secretion of saliva ( salivation ) is mediated by parasympathetic stimulation ; acetylcholine is the active neurotransmitter and binds to muscarinic receptors in the glands, leading to increased salivation. Contents 1 Structure 1.1 Parotid glands 1.2 Submandibular glands 1.3 Sublingual glands 1.4 Minor salivary glands 1.5 Von Ebner 's glands 1.6 Nerve supply 1.7 Microanatomy 1.7. 1 Acini 1.7. 2 Ducts 1.8 Gene and protein expression 2 Development 2.1 Aging 3 Function 4 Clinical significance 4.1 Clinical tests / investigations 5 Other animals 6 See also 7 References 8 External links Structure Salivary glands : # 1 Parotid gland, # 2 Submandibular gland, # 3 Sublingual gland. The salivary glands are detailed below : Parotid glands Main article : Parotid gland The two parotid glands are major salivary glands wrapped around the mandibular ramus in humans. These are largest of the salivary glands, secreting saliva to facilitate mastication and swallowing, and amylase to begin the digestion of starches. It is the serous type of gland which secretes alpha - amylase ( also known as ptyalin ). It enters the oral cavity via the parotid duct. The glands are located posterior to the mandibular ramus and anterior to the mastoid process of the temporal bone. They are clinically relevant in dissections of facial nerve branches while exposing the different lobes, since any iatrogenic lesion will result in either loss of action or strength of muscles involved in facial expression. They produce 20 % of the total salivary content in the oral cavity. Mumps is a viral infection, caused by infection in the parotid gland. Submandibular glands Main article : Submandibular gland The submandibular glands ( previously known as submaxillary glands ) are a pair of major salivary glands located beneath the lower jaws, superior to the digastric muscles. The secretion produced is a mixture of both serous fluid and mucus, and enters the oral cavity via the submandibular duct or Wharton duct. Approximately 65 - 70 % of saliva in the oral cavity is produced by the submandibular glands, even though they are much smaller than the parotid glands. This gland can usually be felt via palpation of the neck, as it is in the superficial cervical region and feels like a rounded ball. It is located about two fingers above the Adam 's apple ( laryngeal prominence ) and about two inches apart under the chin. Sublingual glands Main article : Sublingual gland The sublingual glands are a pair of major salivary glands located inferior to the tongue, anterior to the submandibular glands. The secretion produced is mainly mucous in nature ; however, it is categorized as a mixed gland. Unlike the other two major glands, the ductal system of the sublingual glands does not have intercalated ducts and usually does not have striated ducts either, so saliva exits directly from 8 - 20 excretory ducts known as the Rivinus ducts. Approximately 5 % of saliva entering the oral cavity comes from these glands. Minor salivary glands There are 800 to 1,000 minor salivary glands located throughout the oral cavity within the submucosa of the oral mucosa in the tissue of the buccal, labial, and lingual mucosa, the soft palate, the lateral parts of the hard palate, and the floor of the mouth or between muscle fibers of the tongue. They are 1 to 2 mm in diameter and unlike the major glands, they are not encapsulated by connective tissue, only surrounded by it. The gland has usually a number of acini connected in a tiny lobule. A minor salivary gland may have a common excretory duct with another gland, or may have its own excretory duct. Their secretion is mainly mucous in nature and have many functions such as coating the oral cavity with saliva. Problems with dentures are sometimes associated with minor salivary glands if there is dry mouth present ( see further discussion ). The minor salivary glands are innervated by the seventh cranial or facial nerve. Von Ebner 's glands Main article : Von Ebner 's glands Von Ebner 's glands are glands found in a trough circling the circumvallate papillae on the dorsal surface of the tongue near the terminal sulcus. They secrete a purely serous fluid that begins lipid hydrolysis. They also facilitate the perception of taste through secretion of digestive enzymes and proteins. The arrangement of these glands around the circumvallate papillae provides a continuous flow of fluid over the great number of taste buds lining the sides of the papillae, and is important for dissolving the food particles to be tasted. Nerve supply Salivary glands are innervated, either directly or indirectly, by the parasympathetic and sympathetic arms of the autonomic nervous system. Parasympathetic stimulation evokes a copious flow of saliva. In contrast, sympathetic stimulation produces either a small flow, which is rich in protein, or no flow at all. Parasympathetic innervation to the salivary glands is carried via cranial nerves. The parotid gland receives its parasympathetic input from the glossopharyngeal nerve ( CN IX ) via the otic ganglion, while the submandibular and sublingual glands receive their parasympathetic input from the facial nerve ( CN VII ) via the submandibular ganglion. These nerves release acetylcholine and substance P, which activate the IP3 and DAG pathways respectively. Direct sympathetic innervation of the salivary glands takes place via preganglionic nerves in the thoracic segments T1 - T3 which synapse in the superior cervical ganglion with postganglionic neurons that release norepinephrine, which is then received by β - adrenergic receptors on the acinar and ductal cells of the salivary glands, leading to an increase in cyclic adenosine monophosphate ( cAMP ) levels and the corresponding increase of saliva secretion. Note that in this regard both parasympathetic and sympathetic stimuli result in an increase in salivary gland secretions. The sympathetic nervous system also affects salivary gland secretions indirectly by innervating the blood vessels that supply the glands. Microanatomy The gland is internally divided into lobules. Blood vessels and nerves enter the glands at the hilum and gradually branch out into the lobules. Acini Secretory cells are found in a group, or acinus ( plural, acini ). Each acinus is located at the terminal part of the gland connected to the ductal system, with many acini within each lobule of the gland. Each acinus consists of a single layer of cuboidal epithelial cells surrounding a lumen, a central opening where the saliva is deposited after being produced by the secretory cells. The three forms of acini are classified in terms of the type of epithelial cell present and the secretory product being produced : serous, mucoserous and mucous. Ducts In the duct system, the lumina are formed by intercalated ducts, which in turn join to form striated ducts. These drain into ducts situated between the lobes of the gland ( called interlobar ducts or secretory ducts ). These are found on most major and minor glands ( exception may be the sublingual gland ). All of the human salivary glands terminate in the mouth, where the saliva proceeds to aid in digestion. The saliva that salivary glands release is quickly inactivated in the stomach by the acid that is present, however saliva also contains enzymes that are actually activated by stomach acid. Gene and protein expression About 20,000 protein coding genes are expressed in human cells and 60 % of these genes are expressed in normal, adult salivary glands. Less than 100 genes are more specifically expressed in the salivary gland. The salivary gland specific genes are mainly genes that encode for secreted proteins and compared to other organs in the human body ; the salivary gland has the highest fraction of secreted genes. The heterogeneous family of proline - rich, human salivary glycoproteins, such as PRB1 and PRH1, are salivary gland specific proteins with highest level of expression. Examples of other specifically expressed proteins include the digestive amylase enzyme AMY1A, the mucin MUC7 and statherin, all of major importance for specific characteristics of saliva. Development This section needs expansion. You can help by adding to it. ( January 2018 ) Aging Aging of salivary glands show some structural changes, such as : Decrease in volume of acinar tissue Increase in fibrous tissue Increase in adipose tissue Ductal hyperplasia and dilation In addition, there are also changes in salivary contents : Decrease in concentration of secretory IgA Decrease in the amount of mucin However, there is no overall change in the amount of saliva secreted. Function Further information : Digestion This section needs expansion. You can help by adding to it. ( January 2018 ) Salivary glands secrete saliva which has many benefits for the oral cavity and health in general. These benefits include : Protection Saliva consists of proteins ( for example ; mucins ) that lubricate and protect both the soft and hard tissues of the oral cavity. Mucins are the principal organic constituents of mucus, the slimy visco - elastic material that coats all mucosal surfaces. Buffering In general, the higher the saliva flow rate, the faster the clearance and the higher the buffer capacity, hence better protection from dental caries. Therefore, people with a slower rate of saliva secretion, combined with a low buffer capacity, have lessened salivary protection against microbes. Pellicle formation Saliva forms a pellicle on the surface of the tooth to prevent wearing. The film contains mucins and proline - rich glycoprotein from the saliva. The proteins ( statherin and proline - rich proteins ) within the salivary pellicle inhibit demineralisation and promote remineralisation by attracting calcium ions. Maintenance of tooth integrity Demineralization occurs when enamel disintegrates due to the presence of acid. When this occurs, the buffering capacity effect of saliva ( increases saliva flow rate ) inhibits demineralisation. Saliva can then begin to promote the remineralisation of the tooth by strengthening the enamel with calcium and phosphate minerals. Antimicrobial action Saliva can prevent microbial growth based on the elements it contains. For example, lactoferrin in saliva binds naturally with iron. Since iron is a major component of bacterial cell walls, removal of iron breaks down the cell wall, which in turn breaks down the bacteria. Antimicrobial peptides such as histatins inhibit the growth of Candida albicans and Streptococcus mutans. Salivary Immunoglobulin A serves to aggregate oral bacteria such as S. mutans and prevent the formation of dental plaque. Tissue repair Saliva can encourage soft tissue repair by decreasing clotting time and increasing wound contraction. Digestion Saliva contains the enzyme amylase, which hydrolyses starch into maltose and dextrin. As a result, saliva allows digestion to occur before the food reaches the stomach. Taste Saliva acts as a solvent in which solid particles can dissolve in and enter the taste buds through oral mucosa located on the tongue. These taste buds are found within foliate and circumvallate papillae, where minor salivary glands secrete saliva. Clinical significance Micrograph of chronic inflammation of the salivary gland sialadenitis ). Main article : Salivary gland disease A sialolithiasis ( a salivary calculus or stone ) may cause blockage of the ducts, most commonly the submandibular ducts, causing pain and swelling of the gland. Salivary gland dysfunction refers to either xerostomia ( the symptom of dry mouth ) or salivary gland hypofunction ( reduced production of saliva ) ; it is associated with significant impairment of quality of life. Following radiotherapy of the head and neck region, salivary gland dysfunction is a predictable side - effect. Saliva production may be pharmacologically stimulated by sialagogues such as pilocarpine and cevimeline. It can also be suppressed by so - called antisialagogues such as tricyclic antidepressants, SSRIs, antihypertensives, and polypharmacy. A Cochrane review found there was no strong evidence that topical therapies are effective in relieving the symptoms of dry mouth. Cancer treatments including chemotherapy and radiation therapy may impair salivary flow. Radiotherapy can cause permanent hyposalivation due to injury to the oral mucosa containing the salivary glands, resulting in xerostomia, whereas chemotherapy may cause only temporary salivary impairment. Graft versus host disease after allogeneic bone marrow transplantation may manifest as dry mouth and many small mucoceles. Salivary gland tumours may occur, including mucoepidermoid carcinoma, a malignant growth. Clinical tests / investigations A sialogram is a radiocontrast study of a salivary duct that may be used to investigate its function and for diagnosing Sjögren syndrome. Other animals The salivary glands of some species are modified to produce proteins - salivary amylase is found in many, but by no means all, bird and mammal species ( including humans, as noted above ). Furthermore, the venom glands of venomous snakes ( colloquially called poisonous snakes ), Gila monsters, and some shrews, are actually modified salivary glands. In other organisms such as insects, salivary glands are often used to produce biologically important proteins like silk or glues, whilst fly salivary glands contain polytene chromosomes that have been useful in genetic research. See also Serous demilune Sialome References ^ Jump up to : Edgar, Michael ; Dawes, Colin ; O'Mullane, Denis, eds. ( 2012 ). Saliva and oral health ( 4th ed. ). Little Steine, Hill Farm Lane, Duns Tew, OX25 6JH : Stephen Hancocks Limited. p. 1. ISBN 978 - 0 - 9565668 - 3 - 6. Jump up ^ Martini, Frederic H. ; Nath, Judi L. ; Bartholomew, Edwin ( 2012 ). 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Salivary gland at the Human Protein Atlas Illustration at merck.com Illustration at. washington.edu plastic / 371 at eMedicine - `` Parotid Tumors, Benign '' Medical Encyclopedia Medline Plus : Salivary gland Anatomy of the mouth Lip Vermilion border Frenulum of lower lip Labial commissure of mouth Philtrum Cheek Buccal fat pad Roof Hard palate Soft palate Palatine raphe Incisive papilla Gums Interdental papilla Gingival sulcus Gingival margin Gingival fibers Junctional epithelium Mucogingival junction Sulcular epithelium Stippling Periodontium Cementum Gingiva Periodontal ligament Glands Parotid gland duct Submandibular gland duct Sublingual gland duct Teeth see tooth anatomy Tongue Top Taste bud Median sulcus Terminal sulcus Foramen cecum Lingual tonsils Underside Frenulum Fimbriated fold Sublingual caruncle Glossoepiglottic folds Lingual septum Back of mouth Oropharynx fauces Plica semilunaris of the fauces Uvula Palatoglossal arch Palatopharyngeal arch Tonsillar fossa Palatine tonsil NDL : 00561185 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Salivary_gland&oldid=854709882 '' Categories : Glands of mouth Exocrine system Saliva Arthropod glands Hidden categories : Pages with unresolved properties Pages with DOIs inactive since 2018 Articles to be expanded from January 2018 All articles to be expanded Articles using small message boxes Wikipedia articles with NDL identifiers Talk Contents About Wikipedia Afrikaans Bân - lâm - gú Беларуская Български Bosanski Català Чӑвашла Čeština Cymraeg Dansk Deutsch ދިވެހިބަސް Eesti Ελληνικά Español Euskara فارسی Français Gaeilge Galego 한국어 Հայերեն हिन्दी Hrvatski Bahasa Indonesia Íslenska Italiano עברית Basa Jawa Қазақша Kurdî Кыргызча Latina Latviešu Lietuvių Limburgs Magyar Македонски മലയാളം Nederlands 日本 語 Norsk Norsk nynorsk Polski Português Română Runa Simi Русский සිංහල Simple English Slovenčina Slovenščina Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska தமிழ் Татарча / tatarça తెలుగు ไทย Türkçe Українська ئۇيغۇرچە / Uyghurche Tiếng Việt Võro 中文 58 more Edit links This page was last edited on 13 August 2018, at 07 : 29 ( UTC ). 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Question: where is the salivary gland located in humans
Answer: the mouth