Agglutination ( biology ) - wikipedia Agglutination ( biology ) This article relies largely or entirely on a single source. Relevant discussion may be found on the talk page. Please help improve this article by introducing citations to additional sources. ( June 2015 ) Agglutination is the clumping of particles. The word agglutination comes from the Latin agglutinare ( glueing to ). Agglutination is the process that occurs if an antigen is mixed with its corresponding antibody called isoagglutinin. This term is commonly used in blood grouping. This occurs in biology in three main examples : The clumping of cells such as bacteria or red blood cells in the presence of an antibody or complement. The antibody or other molecule binds multiple particles and joins them, creating a large complex. This increases the efficacy of microbial elimination by phagocytosis as large clumps of bacteria can be eliminated in one pass, versus the elimination of single microbial antigens. When people are given blood transfusions of the wrong blood group, the antibodies react with the incorrectly transfused blood group and as a result, the erythrocytes clump up and stick together causing them to agglutinate. The coalescing of small particles that are suspended in a solution ; these larger masses are then ( usually ) precipitated. Contents 1 In hematology 1.1 Hemagglutination 1.2 Leukoagglutination 2 In microbiology 3 History of discoveries 4 See also 5 References In hematology Hemagglutination The ' bedside card ' method of blood typing, in this case using a Serafol card. The result is blood group A positive. Main article : Hemagglutination Hemagglutination is the process by which red blood cells agglutinate, meaning clump or clog. The agglutin involved in hemagglutination is called hemagglutinin. In cross-matching, donor red blood cells and recipient 's serum or plasma are incubated together. If agglutination occurs, this indicates that the donor and recipient blood types are incompatible. Leukoagglutination Leukoagglutination occurs when the particles involved are white blood cells. An example is the PH - L form of phytohaemagglutinin. In microbiology Agglutination is commonly used as a method of identifying specific bacterial antigens, and in turn, the identity of such bacteria. Because the clumping reaction occurs quickly and is easy to produce, agglutination is an important technique in diagnosis. History of discoveries Two bacteriologists, Herbert Edward Durham ( - 1945 ) and Max von Gruber ( 1853 -- 1927 ), discovered specific agglutination in 1896. The clumping became known as Gruber - Durham reaction. Gruber introduced the term agglutinin ( from the Latin ) for any substance that caused agglutination of cells. French physician Fernand Widal ( 1862 -- 1929 ) put Gruber and Durham 's discovery to practical use later in 1896, using the reaction as the basis for a test for typhoid fever. Widal found that blood serum from a typhoid carrier caused a culture of typhoid bacteria to clump, whereas serum from a typhoid - free person did not. This Widal test was the first example of serum diagnosis. Austrian physician Karl Landsteiner found another important practical application of the agglutination reaction in 1900. Landsteiner 's agglutination tests and his discovery of ABO blood groups was the start of the science of blood transfusion and serology which has made transfusion possible and safer. See also Agglutination - PCR Blocking antibody Coagulation Immune system Macrophage Mannan oligosaccharides ( MOS ) References hide Medical tests used in immunology and for inflammation ( CPT 86000 -- 86849 ) Immunology Immunoprecipitation Chromatin immunoprecipitation Immunodiffusion Ouchterlony double immunodiffusion Radial immunodiffusion Immunoelectrophoresis Counterimmunoelectrophoresis Immunoassay ELISA ELISPOT Enzyme Multiplied Immunoassay Technique RAST test Radioimmunoassay Radiobinding assay Immunofluorescence Agglutination Hemagglutination / Hemagglutinin Coombs test Latex fixation test Other Diagnostic immunology Nephelometry Complement fixation test Immunocytochemistry Immunohistochemistry Direct fluorescent antibody Epitope mapping Skin allergy test Patch test Inflammation C - reactive protein Procalcitonin Total complement activity MELISA Complete blood count lymphocyte count Retrieved from `` https://en.wikipedia.org/w/index.php?title=Agglutination_(biology)&oldid=844492698 '' Categories : Immunologic tests Hematology Hidden categories : Articles needing additional references from June 2015 All articles needing additional references Talk Contents About Wikipedia Български Čeština Dansk Español Euskara فارسی Français Galego Bahasa Indonesia ქართული Қазақша Nederlands 日本 語 Polski Português Русский Suomi Tagalog Türkçe Українська 12 more Edit links This page was last edited on 5 June 2018, at 08 : 26 ( UTC ). 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Question: when does clumping occur during a blood transfusion
Answer: When people are given blood transfusions of the wrong blood group