Transitional epithelium - wikipedia Transitional epithelium Transitional epithelium Transitional striated epithelium Identifiers TH H2. 00.02. 0.02033 Anatomical terms of microanatomy ( edit on Wikidata ) This article is one of a series on Epithelia Squamous epithelial cell Simple Stratified Columnar epithelial cell Simple Stratified Pseudostratified Cuboidal epithelial cell Simple Stratified Specialised epithelia Olfactory Respiratory Intestinal Transitional Vaginal Germinal female male Other Table of epithelia of human organs Transitional epithelium is a type of stratified epithelium -- tissue consisting of multiple layers of epithelial cells which can contract and expand as needed. It is so named because of this function in the transition of degree of distension. This tissue structure type is found in urothelium, including that of the renal pelvis, urinary bladder, the ureters, the superior urethra, and the prostatic and ejaculatory ducts of the prostate. Contents 1 Structure 1.1 Cell layers 1.2 Cell membrane 2 Function 3 Clinical significance 3.1 Carcinoma 4 Gallery 5 References 6 External links Structure The appearance of transitional epithelium depends on the layers in which it resides. Cells of the basal layer are cuboidal, or cube - shaped, and columnar, or column - shaped, while the cells of the superficial layer vary in appearance depending on the degree of distension. These cells appear to be cuboidal with a domed apex when the organ or the tube in which they reside is not stretched. When the organ or tube is stretched ( e.g. when the bladder is filled with urine ), the tissue compresses and the cells become stretched. When this happens, the cells flatten, and they appear to be squamous and irregular. Cell layers Transitional epithelium is made up of three types of cell layers : basal, intermediate, and superficial. The basal layer fosters the epithelial stem cells in order to provide constant renewal of the epithelium. These cells ' cytoplasm is rich in tonofilaments and mitochondria ; however, they contain few rough endoplasmic reticulum. The tonofilaments play a role in the attachment of the basal layer to the basement membrane via desmosomes. The intermediate cell layer is highly proliferative and, therefore, provides for rapid cell regeneration in response to injury or infection of the organ or tube in which it resides. These cells contain a prominent Golgi apparatus and an array of membrane - bound vesicles. These function in the packaging and transport of proteins, such as keratin, to the superficial cell layer. The superficial cell layer, that which lines the lumen, is the only fully differentiated layer of the epithelium. It provides an impenetrable barrier between the lumen and the bloodstream, so as not to allow the bloodstream to reabsorb harmful wastes or pathogens. All transitional epithelial cells are covered in microvilli and a fibrillar mucous coat. The epithelium contains many intimate and delicate connections to neural and connective tissue. These connections allow for communication to tell the cells to expand or contract. The superficial layer of transitional epithelium is connected to the basal layer via cellular projections, such as intermediate filaments protruding from the cellular membrane. These structural elements cause the epithelium to allow distension ; however, these also cause the tissue to be relatively fragile and, therefore, difficult to study. All cells touch the basement membrane. Cell membrane Because of its importance in acting as an osmotic barrier between the contents of the urinary tract and the surrounding organs and tissues, transitional epithelium is relatively impermeable to water and salts. This impermeability is due to a highly keratinized cellular membrane synthesized in the Golgi apparatus. The membrane is made up of a hexagonal lattice put together in the Golgi apparatus and implanted into the surface of the cell by reverse pinocytosis, a type of exocytosis. The cells in the superficial layer of the transitional epithelium are highly differentiated, allowing for maintenance of this barrier membrane. The basal layer of the epithelium is much less differentiated ; however, it does act as a replacement source for more superficial layer. While the Golgi complex is much less prominent in the cells of the basal layer, these cells are rich in cytoplasmic proteins that bundle together to form tonofibrils. These tonofibrils converge at hemidesmosomes to attach the cells at the basement membrane. Function The transitional epithelium cells stretch readily in order to accommodate fluctuation of volume of the liquid in an organ. ( The distal part of the urethra becomes non-keratinized stratified squamous epithelium in females ; the part that lines the bottom of the tissue is called the basement membrane. ) Transitional epithelium also functions as a barrier between the lumen, or inside hollow space of the tract that it lines and the bloodstream. To help achieve this, the cells of transitional epithelium are connected by tight junctions, or virtually impenetrable junctions that seal together to the cellular membranes of neighboring cells. This barrier prevents re-absorption of toxic wastes and pathogens by the bloodstream. Clinical significance Carcinoma Main article : Carcinoma Carcinoma is a type of cancer that occurs in epithelial cells. Transitional cell carcinoma is the leading type of bladder cancer, occurring in 9 out of 10 cases. It is also the leading cause of cancer of the ureter, urethra, and urachus, and the second leading cause of cancer of the kidney. Transitional cell carcinoma can develop in two different ways. Should the transitional cell carcinoma grow toward the inner surface of the bladder via finger - like projections, it is known as papillary carcinoma. Otherwise, it is known as flat carcinoma. Either form can transition from non-invasive to invasive by spreading into the muscle layers of the bladder. Transitional cell carcinoma is commonly multifocal, more than one tumor occurring at the time of diagnosis. Transitional cell carcinoma can metastasize, or spread to other parts of the body via the surrounding tissues, the lymph system, and the bloodstream. It can spread to the tissues and fat surrounding the kidney, the fat surrounding the ureter, or, more progressively, lymph nodes and other organs, including bone. Common risk factors of transitional cell carcinoma include long - term misuse of pain medication, smoking, and exposure to chemicals used in the making of leather, plastic, textiles, and rubber. Transitional cell carcinoma patients have a variety of treatment options. These include nephroureterectomy, or the removal of kidney, ureter, and bladder cuff, and segmental resection of the ureter. This is an option only when the cancer is superficial and infects only the bottom third of the ureter. The procedure entails removing the segment of cancerous ureter and reattaching the end. Patients with advanced bladder cancer or disease, also often look to bladder reconstruction as a treatment. Current methods of bladder reconstruction include the use of gastrointestinal tissue. However, while this method is effective in improving the function of the bladder, it can actually increases the risk of cancer, and can cause other complications, such as infections, urinary stones, and electrolyte imbalance. Therefore, other methods loom in the future. For example, current research paves the way for use of pluripotent stem cells to derive urothelium, as they are highly and indefinitely proliferative in vitro ( i.e. outside of the body ). Gallery Types of epithelium Schematic view of transitional epithelium Vertical section of bladder wall. References Jump up ^ Marieb, E., & Hoehn, K. ( 2013 ). Human anatomy & physiology ( 9th ed., pp. 122 - 124 ). Boston : Pearson. ^ Jump up to : Monis, B., & Zambrano, D. ( 1968 ). Ultrastructure of transitional epithelium of man. Zeitschrift für Zellforschung und Microscopical Anatomie, 87 ( 1 ), 101 - 117. ^ Jump up to : Osborn, S.L., & Kurzrock, E.A. ( 2015 ). Production of Urothelium from Pluripotent Stem Cells for Regenerative Applications. Current Urology Reports, 16 ( 1 ), 1 +. Retrieved from http://go.galegroup.com/ps/i.do?id=GALE%7CA390522720&v=2.1&u=clemsonu_main&it=r&p=AONE&sw=w&asid=bf6961c15c9b9523113dee93fd8df89c ^ Jump up to : Hicks, R. ( 1965 ). The Fine Structure Of The Transitional Epithelium Of Rat Ureter. The Journal of Cell Biology, 26 ( 1 ), 25 - 48. Retrieved November 25, 2014, from http://jcb.rupress.org/content/26/1/25.abstract Jump up ^ Hicks, R. ( 1966 ). THE FUNCTION OF THE GOLGI COMPLEX IN TRANSITIONAL EPITHELIUM : Synthesis of the Thick Cell Membrane. The Journal of Cell Biology, 30 ( 3 ), 623 - 643. Retrieved November 25, 2014, from http://jcb.rupress.org/content/30/3/623.abstract ^ Jump up to : Firth, J.A., & Hicks, R.M. ( 1973 ). Interspecies variation in the fine structure and enzyme cytochemistry of mammalian transitional epithelium. Journal of Anatomy, 116 ( Pt 1 ), 31 -- 43. ^ Jump up to : American Cancer Society. ( 2014 ). Bladder cancer. Retrieved November 25, 2014, from http://www.cancer.org/cancer/bladdercancer/detailedguide/bladder-cancer-what-is-bladder-cancer ^ Jump up to : Transitional Cell Cancer. ( 2012, April 13 ). Retrieved December 14, 2014, from https://my.clevelandclinic.org/health/diseases_conditions/hic_Transitional_Cell_Cancer_of_Renal_Pelvis_and_Ureter External links Histology at utmb.edu Histology image : 36_02 at the University of Oklahoma Health Sciences Center - `` ureter '' Histology image : 37_02 at the University of Oklahoma Health Sciences Center - `` urinary bladder '' Anatomy Atlases - Microscopic Anatomy, plate 02.24 - `` Transitional Epithelium '', Ureter Histology at KUMC urinary - renal16 `` ureter '' Epithelial tissue Cells Squamous Cuboidal Columnar Types Simple squamous epithelium Endothelium Mesothelium Simple cuboidal epithelium Simple columnar epithelium Pseudostratified columnar epithelium Respiratory epithelium Stratified squamous epithelium Stratified cuboidal epithelium Stratified columnar epithelium Transitional epithelium Urothelium Glands Types Mechanism Merocrine Eccrine Apocrine Holocrine Sebaceous Meibomian Shape Tubular gland Alveolar gland Secretion Serous glands Mucous glands Components Myoepithelial cell Serous demilune Ducts : Interlobar Interlobular Intralobular Striated Intercalated Acinus / Lobe Retrieved from `` https://en.wikipedia.org/w/index.php?title=Transitional_epithelium&oldid=827724399 '' Categories : Epithelial cells Hidden categories : Pages with unresolved properties Talk Contents About Wikipedia Čeština Eesti Galego Italiano Nederlands 日本 語 Polski Português Türkçe 中文 3 more Edit links This page was last edited on 26 February 2018, at 10 : 25. 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Question: what kind of epithelium lines the urinary bladder
Answer: Transitional epithelium