Pyrantel - Wikipedia Pyrantel This is the current revision of this page, as edited by Medgirl131 ( talk contribs ) at 22 : 39, 27 August 2017. The present address ( URL ) is a permanent link to this version. Revision as of 22 : 39, 27 August 2017 by Medgirl131 ( talk contribs ) ( diff ) ← Previous revision Latest revision ( diff ) Newer revision → ( diff ) Pyrantel Clinical data Trade names Pin - X, Combantrin, others Pregnancy category US : C ( Risk not ruled out ) Routes of administration by mouth ATC code P02CC01 ( WHO ) QP52AF02 ( WHO ) Identifiers IUPAC name 1 - Methyl - 2 - ( ( E ) - 2 - ( 2 - thienyl ) vinyl ) - 5, 6 - dihydro - 4H - pyrimidine CAS Number 15686 - 83 - 6 PubChem CID 708857 ChemSpider 618121 UNII 4QIH0N49E7 KEGG D08451 ChEBI CHEBI : 8654 ChEMBL CHEMBL1626223 ECHA InfoCard 100.036. 143 Chemical and physical data Formula C H N S Molar mass 206.31 g / mol 3D model ( JSmol ) Interactive image SMILES CN1CCCN = C1 / C = C / c2cccs2 InChI InChI = 1S / C11H14N2S / c1 - 13 - 8 - 3 - 7 - 12 - 11 ( 13 ) 6 - 5 - 10 - 4 - 2 - 9 - 14 - 10 / h2, 4 - 6, 9H, 3, 7 - 8H2, 1H3 / b6 - 5 + Key : YSAUAVHXTIETRK - AATRIKPKSA - N Pyrantel is a medication used to treat a number of parasitic worm infections. This includes ascariasis, hookworm infections, enterobiasis ( pinworm infection ), trichostrongyliasis, and trichinellosis. It is taken by mouth. Side effects include nausea, headache, dizziness, trouble sleeping, and rash. A lower dose should be used in people with liver disease. While there is no evidence of harm if used during pregnancy it has not been studied for this use. It is unclear if it is safe for use during breastfeeding. It is in the antihelmintic family of medications. It works by paralyzing worms. Pyrantel was initially described in 1965. It is on the World Health Organization 's List of Essential Medicines, the most effective and safe medicines needed in a health system. Pyrantel is available as a generic medication. It costs less than 25 USD per course of treatment in the United States. It may also be used to treat worms in a number of other animals. Contents 1 Pregnancy and breastfeeding 2 Mechanism of action 3 Names 4 References Pregnancy and breastfeeding Pyrantel pamoate is considered a Pregnancy category C drug for use during pregnancy for humans, but is in category A for canines and felines. Pyrantel is considered safe to use in nursing animals. Mechanism of action Pyrantel pamoate acts as a depolarizing neuromuscular blocking agent, thereby causing sudden contraction, followed by paralysis, of the helminths. This has the result of causing the worm to `` lose its grip '' on the intestinal wall and be passed out of the system by natural process. Since Pyrantel is poorly absorbed by the host 's intestine, the host is unaffected by the small dosage of medication used. Spastic ( tetanic ) paralyzing agents, in particular pyrantel pamoate, may induce complete intestinal obstruction in a heavy worm load. This obstruction is usually in the form of a worm impaction and happens when a very small, but heavily parasitized animal is treated and tries to pass a large number of dislodged worms at once. Worms usually pass in normal stool or with diarrhea, straining, and occasional vomiting. Names There are a number of brands, including `` Reese 's Pinworm Medicine '', `` Pin - X '', `` Pin - Rid '', `` PYRANTRIN '' formally called `` COMBANTRIN '', `` Anthel '', `` Helmintox '', `` Helmex '', `` Strongid '' and Drontal Cat. References ^ Jump up to : Hamilton, Richart ( 2015 ). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab - Coat Edition. Jones & Bartlett Learning. p. 54. ISBN 9781284057560. ^ Jump up to : WHO Model Formulary 2008 ( PDF ). World Health Organization. 2009. pp. 89, 608. ISBN 9789241547659. Retrieved 8 December 2016. Jump up ^ `` Pyrantel Use During Pregnancy Drugs.com ''. www.drugs.com. Retrieved 8 December 2016. ^ Jump up to : `` Pyrantel Pamoate ''. The American Society of Health - System Pharmacists. Retrieved 8 December 2016. ^ Jump up to : Maddison, Jill E. ; Page, Stephen W. ; ( BVSc. ), David Church ( 2008 ). Small Animal Clinical Pharmacology. Elsevier Health Sciences. p. 209. ISBN 0702028584. Jump up ^ `` WHO Model List of Essential Medicines ( 19th List ) '' ( PDF ). World Health Organization. April 2015. Retrieved 8 December 2016. Jump up ^ Plumb, D.C. ( 2005 ). Plumb 's veterinary drug handbook. Stockholm, Wis : PharmaVet. ISBN 0 - 8138 - 0518 - X. Jump up ^ Salman, A.B. ( 1997 ). `` Management of intestinal obstruction caused by ascariasis ''. Journal of Pediatric Surgery. 32 ( 4 ) : 585 -- 587. PMID 9126759. doi : 10.1016 / S0022 - 3468 ( 97 ) 90712 - 0. Antiparasitics -- Anthelmintics ( P02 ) and Endectocides ( QP54 ) Antiplatyhelmintic agents Antitrematodals ( schistosomicides ) Binds tubulin benzimidazole Triclabendazole AI phosphonic acid Metrifonate Other / unknown quinoline Praziquantel Oxamniquine phenol Bithionol thiazole Niridazole arylsulfonate Stibophen Anticestodals ( taeniacides ) Binds tubulin benzimidazole Albendazole Other / unknown quinoline Praziquantel salicylanilide Niclosamide aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen Antinematodal agents ( including macrofilaricides ) Binds tubulin benzimidazole Mebendazole Albendazole Tiabendazole Fenbendazole Ciclobendazole Flubendazole Glutamate - gated chloride channel, GABA receptor avermectins Abamectin Doramectin Emamectin Ivermectin Selamectin milbemycins Moxidectin Milbemycin oxime NMDA tetrahydropyrimidine Pyrantel pyrantel pamoate Oxantel Morantel Carbantel Febantel ( aka felsantel ) Other / unknown piperazine Piperazine Diethylcarbamazine thiazole Levamisole quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin Tribendimidine WHO - EM Withdrawn from market Clinical trials : Phase III Never to phase III Nicotinic acetylcholine receptor modulators nAChRs Agonists : 5 - HIAA A-84,543 A-366,833 A-582,941 A-867,744 ABT - 202 ABT - 418 ABT - 560 ABT - 894 Acetylcholine Altinicline Anabasine Anatoxin - a AR - R17779 Bephenium hydroxynaphthoate Butinoline Butyrylcholine Carbachol Choline Cotinine Cytisine Decamethonium Desformylflustrabromine Dianicline Dimethylphenylpiperazinium Epibatidine Epiboxidine Ethanol Ethoxysebacylcholine EVP - 4473 EVP - 6124 Galantamine GTS - 21 Ispronicline Ivermectin Levamisole Lobeline MEM - 63,908 ( RG - 3487 ) Morantel Nicotine ( tobacco ) NS - 1738 PHA - 543,613 PHA - 709,829 PNU - 120,596 PNU - 282,987 Pozanicline Pyrantel Rivanicline RJR - 2429 Sazetidine A SB - 206553 Sebacylcholine SIB - 1508Y SIB - 1553A SSR - 180,711 Suberyldicholine Suxamethonium ( succinylcholine ) Suxethonium ( succinyldicholine ) TC - 1698 TC - 1734 TC - 1827 TC - 2216 TC - 5214 TC - 5619 TC - 6683 Tebanicline Tribendimidine Tropisetron UB - 165 Varenicline WAY - 317,538 XY - 4083 Antagonists : 18 - MAC 18 - MC α - Neurotoxins ( e.g., α - bungarotoxin, α - cobratoxin, α - conotoxin, many others ) ABT - 126 Alcuronium Allopregnanolone Amantadine Anatruxonium AQW051 Atracurium Barbiturates ( e.g., pentobarbital, sodium thiopental ) BNC - 210 Bungarotoxins ( e.g., α - bungarotoxin, κ - bungarotoxin ) Bupropion BW - A444 Candocuronium iodide ( chandonium iodide ) Chlorisondamine Cisatracurium Coclaurine Coronaridine Curare Cyclopropane Dacuronium bromide Decamethonium Dehydronorketamine Desflurane Dextromethorphan Dextropropoxyphene Dextrorphan Diadonium DHβE Dihydrochandonium Dimethyltubocurarine ( metocurine ) Dioscorine Dipyrandium Dizocilpine ( MK - 801 ) Doxacurium Encenicline Enflurane Erythravine Esketamine Fazadinium Gallamine Gantacurium chloride Halothane Hexafluronium Hexamethonium ( benzohexonium ) Hydroxybupropion Hydroxynorketamine Ibogaine Isoflurane Ketamine Kynurenic acid Laudanosine Laudexium ( laudolissin ) Levacetylmethadol Levomethadone Malouetine ME - 18 - MC Mecamylamine Memantine Methadone Methorphan ( racemethorphan ) Methyllycaconitine Metocurine Mivacurium Morphanol ( racemorphan ) Neramexane Nitrous oxide Norketamine Pancuronium bromide Pempidine Pentamine Pentolinium Phencyclidine Pipecuronium bromide Progesterone Promegestone Radafaxine Rapacuronium bromide Reboxetine Rocuronium bromide Sevoflurane Stercuronium iodide Surugatoxin Thiocolchicoside Toxiferine Tramadol Trimetaphan camsilate ( trimethaphan camsylate ) Tropeinium Tubocurarine Vanoxerine Vecuronium bromide Xenon Precursors ( and prodrugs ) Acetyl - coA Adafenoxate Choline ( lecithin ) Citicoline Cyprodenate Dimethylethanolamine Glycerophosphocholine Meclofenoxate ( centrophenoxine ) Phosphatidylcholine Phosphatidylethanolamine Phosphorylcholine Pirisudanol See also : Receptor / signaling modulators Muscarinic acetylcholine receptor modulators Acetylcholine metabolism / transport modulators This antiinfective drug article is a stub. You can help Wikipedia by expanding it. Retrieved from `` https://en.wikipedia.org/w/index.php?title=Pyrantel&oldid=797568194 '' Categories : Nicotinic agonists Thiophenes World Health Organization essential medicines Pyrimidines Antiinfective agent stubs Hidden categories : ECHA InfoCard ID from Wikidata Chemical pages without DrugBank identifier Drugs with no legal status Articles containing unverified chemical infoboxes RTT All stub articles Talk Article Talk More Contents About Wikipedia العربية Čeština Deutsch Español فارسی Français Italiano Magyar 日本 語 ଓଡ଼ିଆ Polski Português Română Русский Српски / srpski Srpskohrvatski / српскохрватски Українська Edit links This page was last edited on 27 August 2017, at 22 : 39. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. 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Question: what kind of worms does pyrantel pamoate kill
Answer: parasitic