Renal glucose reabsorption - wikipedia Renal glucose reabsorption Renal glucose reabsorption is the part of kidney ( renal ) physiology that deals with the retrieval of filtered glucose, preventing it from disappearing from the body through the urine. If glucose is not reabsorbed by the kidney, it appears in the urine, in a condition known as glucosuria. This is associated with diabetes mellitus. Firstly, the glucose in the proximal tubule is co-transported with sodium ions into the proximal convoluted tubule walls via the SGLT2 cotransporter. Some ( typically smaller ) amino acids are also transported in this way. Once in the tubule wall, the glucose and amino acids diffuse directly into the blood capillaries along a concentration gradient. This blood is flowing, so the gradient is maintained. Lastly, sodium / potassium ion active transport pumps remove sodium from the tubule wall and the sodium is put back into the blood. This maintains a sodium concentration gradient in the proximal tubule lining, so the first step continues to happen. Gliflozins such as canagliflozin inhibit renal glucose reabsorption, and are used in diabetes mellitus to lower blood glucose. Overview table Characteristics of glucose reabsorption Characteristic Proximal tubule Loop of Henle Distal convoluted tubule Collecting duct system S1 S2 S3 Reabsorption ( % ) 98 Beyond the distal convoluted tubule : 2 % Reabsorption ( mmol / day ) Concentration Apical transport proteins SGLT2 SGLT1 Basolateral transport proteins GLUT2 GLUT1 Other reabsorption features References Jump up ^ Sect. 7, Ch. 6 : Characteristics of Proximal Glucose Reabsorption Jump up ^ Balis, Dainius A ; Tong, Cindy ; Meininger, Gary ( July 2014 ). `` Effect of canagliflozin, a sodium -- glucose cotransporter 2 inhibitor, on measurement of serum 1, 5 - anhydroglucitol ''. J Diabetes. 6 ( 4 ) : 378 -- 380. doi : 10.1111 / 1753 - 0407.12116. ^ Jump up to : Walter F., PhD. Boron. Medical Physiology : A Cellular And Molecular Approaoch. Elsevier / Saunders. ISBN 1 - 4160 - 2328 - 3. Page 793 Physiology of the kidneys and acid - base physiology Renal function Secretion clearance Pharmacokinetics Clearance of medications Urine flow rate Reabsorption Solvent drag sodium chloride urea glucose oligopeptides protein Renal function Glomerular filtration rate Creatinine clearance Renal clearance ratio Urea reduction ratio Kt / V Standardized Kt / V Measures of dialysis Hemodialysis product PAH clearance ( Effective renal plasma flow Extraction ratio ) Filtration Renal blood flow Ultrafiltration Countercurrent exchange Filtration fraction Hormones Antidiuretic hormone Aldosterone Atrial natriuretic peptide Renin Erythropoietin Calcitriol Prostaglandins Acid - base balance Fluid balance Darrow Yannet diagram Body water : Intracellular fluid / Cytosol Extracellular fluid ( Interstitial fluid Plasma Transcellular fluid ) Base excess Davenport diagram Anion gap Arterial blood gas Winter 's formula Buffering Bicarbonate buffer system Respiratory compensation Renal compensation Other Fractional sodium excretion BUN - to - creatinine ratio Tubuloglomerular feedback Natriuresis Urine Retrieved from `` https://en.wikipedia.org/w/index.php?title=Renal_glucose_reabsorption&oldid=752012417 '' Categories : Renal physiology Talk About Wikipedia Add links This page was last edited on 29 November 2016, at 00 : 48. Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia ® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization. About Wikipedia

Question: where does primary active transport of sodium occur in the proximal convoluted tubule cells
Answer: walls