Acromegaly - wikipedia Acromegaly Acromegaly Facial features of a person with acromegaly. The cheekbones are pronounced, the forehead bulges, the jaw is enlarged, and facial lines are prominent. Pronunciation / ˌækrəˈmɛɡəli, - roʊ - / ; Specialty Endocrinology Symptoms Enlargement of the hands, feet, forehead, jaw, and nose, thicker skin, deepening of the voice Complications Type 2 diabetes, sleep apnea, high blood pressure Usual onset Middle age Causes Too much growth hormone Diagnostic method Blood tests, medical imaging Similar conditions Pachydermoperiostosis Treatment Surgery, medications, radiation therapy Medication Somatostatin analogue, GH receptor antagonist Prognosis Usually normal ( with treatment ), 10 year shorter life expectancy ( no treatment ) Frequency 6 per 100,000 people ( edit on Wikidata ) Acromegaly is a disorder that results from excess growth hormone ( GH ) after the growth plates have closed. The initial symptom is typically enlargement of the hands and feet. There may also be enlargement of the forehead, jaw, and nose. Other symptoms may include joint pain, thicker skin, deepening of the voice, headaches, and problems with vision. Complications of the disease may include type 2 diabetes, sleep apnea, and high blood pressure. Acromegaly is typically due to the pituitary gland producing too much growth hormone. In more than 95 % of cases the excess production is due to a benign tumor, known as a pituitary adenoma. The condition is not inherited from a person 's parents. Rarely acromegaly is due to tumors in other parts of the body. Diagnosis is by measuring growth hormone after a person has drunk glucose or by measuring insulin - like growth factor I in the blood. After diagnosis, medical imaging of the pituitary is carried out to look for an adenoma. If excess growth hormone is produced during childhood the result is gigantism. Treatment options include surgery to remove the tumor, medications, and radiation therapy. Surgery is usually the preferred treatment and is most effective when the tumor is smaller. In those in whom surgery is not effective, medications of the somatostatin analogue or GH receptor antagonist type may be used. The effects of radiation therapy are more gradual than that of surgery or medication. Without treatment those affected live on average 10 years less ; however, with treatment life expectancy is typically normal. Acromegaly affects about 6 per 100,000 people. It is most commonly diagnosed in middle age. Males and females are affected with equal frequency. The first medical description of the disorder occurred in 1772 by Nicolas Saucerotte. The term is from Greek ἄκρον akron meaning `` extremity '' and μέγα mega meaning `` large ''. Contents 1 Signs and symptoms 1.1 Complications 2 Causes 2.1 Pituitary adenoma 2.2 Other tumors 3 Diagnosis 3.1 Pseudoacromegaly 4 Treatment 4.1 Medications 4.1. 1 Somatostatin analogues 4.1. 2 Dopamine agonists 4.1. 3 Growth hormone receptor antagonists 4.2 Surgery 4.3 Radiation therapy 4.4 Choices 5 Prognosis 6 Notable cases 7 See also 8 References 9 External links Signs and symptoms Compared with the hand of a typical person ( left ), the hand of a patient with acromegaly ( right ) is enlarged, with fingers that are widened, thickened and stubby, and with thicker soft tissue Mandibular overgrowth leads to prognathism, maxillary widening, teeth spacing and malocclusion Brow ridge and forehead protrusion remaining after tumor removal and tissue swelling eliminated Lower jaw showing the classic spacing of teeth due to acromegaly Features that result from high level of GH or expanding tumor include : Soft tissue swelling visibly resulting in enlargement of the hands, feet, nose, lips and ears, and a general thickening of the skin Soft tissue swelling of internal organs, notably the heart with attendant weakening of its muscularity, and the kidneys, also the vocal cords resulting in a characteristic thick, deep voice and slowing of speech Generalized expansion of the skull at the fontanelle Pronounced brow protrusion, often with ocular distension ( frontal bossing ) Pronounced lower jaw protrusion ( prognathism ) with attendant macroglossia ( enlargement of the tongue ) and teeth spacing Hypertrichosis, hyperpigmentation and hyperhidrosis may occur in these patients. Acrochordon ( skin tags ) Carpal tunnel syndrome Complications Severe headache Arthritis and carpal tunnel syndrome Enlarged heart Liver fibrosis and bile duct hyperplasia. Hypertension Diabetes mellitus ( excess of GH leads to insulin resistance ) Heart failure Kidney failure Colorectal cancer Compression of the optic chiasm leading to loss of vision in the outer visual fields ( typically bitemporal hemianopia. ) Increased palmar sweating and sebum production over the face ( seborrhea ) are clinical indicators of active GH - producing pituitary tumors. These symptoms can also be used to monitor the activity of the tumor after surgery, although biochemical monitoring is confirmatory. Causes Pituitary adenoma About 98 % of cases of acromegaly are due to the overproduction of growth hormone by a benign tumor of the pituitary gland called an adenoma. These tumors produce excessive growth hormone and compress surrounding brain tissues as they grow larger. In some cases, they may compress the optic nerves. Expansion of the tumor may cause headaches and visual disturbances. In addition, compression of the surrounding normal pituitary tissue can alter production of other hormones, leading to changes in menstruation and breast discharge in women and impotence in men because of reduced testosterone production. A marked variation in rates of GH production and the aggressiveness of the tumor occurs. Some adenomas grow slowly and symptoms of GH excess are often not noticed for many years. Other adenomas grow rapidly and invade surrounding brain areas or the sinuses, which are located near the pituitary. In general, younger patients tend to have more aggressive tumors. Most pituitary tumors arise spontaneously and are not genetically inherited. Many pituitary tumors arise from a genetic alteration in a single pituitary cell which leads to increased cell division and tumor formation. This genetic change, or mutation, is not present at birth, but is acquired during life. The mutation occurs in a gene that regulates the transmission of chemical signals within pituitary cells ; it permanently switches on the signal that tells the cell to divide and secrete growth hormones. The events within the cell that cause disordered pituitary cell growth and GH oversecretion currently are the subject of intensive research. Pituitary adenomas and diffuse somatomammotroph hyperplasia may result from somatic activating mutations GNAS, which may be acquired or associated with McCune - Albright syndrome. Other tumors In a few patients, acromegaly is caused not by pituitary tumors, but by tumors of the pancreas, lungs, and adrenal glands. These tumors also lead to an excess of GH, either because they produce GH themselves or, more frequently, because they produce GHRH ( growth hormone releasing hormone ), the hormone that stimulates the pituitary to make GH. In these patients, the excess GHRH can be measured in the blood and establishes that the cause of the acromegaly is not due to a pituitary defect. When these nonpituitary tumors are surgically removed, GH levels fall and the symptoms of acromegaly improve. In patients with GHRH - producing, non-pituitary tumors, the pituitary still may be enlarged and may be mistaken for a tumor. Therefore, it is important that physicians carefully analyze all `` pituitary tumors '' removed from patients with acromegaly so as to not overlook the possibility that a tumor elsewhere in the body is causing the disorder. Diagnosis Frequent blood sampling with serum GH measurement shows that in normal subjects ( left panel ) GH can fluctuate between undetectable levels ( most of the time ) and peaks of up to 30 μg / l ( 90 mIU / l ), owing to the episodic nature of GH secretion, while in patients with acromegaly ( an example is given on right panel ), GH hypersecretion is continuous and GH never returns to undetectable levels. If acromegaly is suspected, medical imaging and medical laboratory investigations are generally used together to confirm or rule out the presence of this condition. IGF1 provides the most sensitive lab test for the diagnosis of acromegaly, and a GH suppression test following an oral glucose load, which is a very specific lab test, will confirm the diagnosis following a positive screening test for IGF1. A single value of the GH is not useful in view of its pulsatality ( levels in the blood vary greatly even in healthy individuals ). Magnetic resonance image of a pituitary macroadenoma that caused acromegaly with compression of the optic chiasm GH levels taken 2 hours after a 75 - or 100 - gram glucose tolerance test are helpful in the diagnosis : GH levels are suppressed below 1 μg / l in normal people, and levels higher than this cutoff are confirmatory of acromegaly. Other pituitary hormones must be assessed to address the secretory effects of the tumor, as well as the mass effect of the tumor on the normal pituitary gland. They include thyroid stimulating hormone ( TSH ), gonadotropic hormones ( FSH, LH ), adrenocorticotropic hormone, and prolactin. An MRI of the brain focusing on the sella turcica after gadolinium administration allows for clear delineation of the pituitary and the hypothalamus and the location of the tumor. A number of other overgrowth syndromes can result in similar problems. Pseudoacromegaly Pseudoacromegaly is a condition with the usual acromegaloid features, but without an increase in growth hormone and IGF - 1. It is frequently associated with insulin resistance. Cases have been reported due to minoxidil at an unusually high dose. It can also be caused by a selective postreceptor defect of insulin signalling, leading to the impairment of metabolic, but preservation of mitogenic, signalling. Treatment There is no known cure for acromegaly. The goals of treatment are to reduce GH production to normal levels, to relieve the pressure that the growing pituitary tumor exerts on the surrounding brain areas, to preserve normal pituitary function, and to reverse or ameliorate the symptoms of acromegaly. Currently, treatment options include surgical removal of the tumor, drug therapy, and radiation therapy of the pituitary. Medications Somatostatin analogues Site of action of the different therapeutic tools in acromegaly. Surgery, radiotherapy, somatostatin analogues and dopamine agonists act at the level of the pituitary adenoma, while GH receptor antagonists act in periphery by blocking the growth hormone receptor and thus impairing the effects of GH on the different tissues. The primary current medical treatment of acromegaly is to use somatostatin analogues -- octreotide ( Sandostatin ) or lanreotide ( Somatuline ). These somatostatin analogues are synthetic forms of a brain hormone, somatostatin, which stops GH production. The long - acting forms of these drugs must be injected every 2 to 4 weeks for effective treatment. Most patients with acromegaly respond to this medication. In many patients, GH levels fall within one hour and headaches improve within minutes after the injection. Octreotide and lanreotide are effective for long - term treatment. Octreotide and lanreotide have also been used successfully to treat patients with acromegaly caused by non-pituitary tumors. Somatostatin analogues are also sometimes used to shrink large tumors before surgery. Because octreotide inhibits gastrointestinal and pancreatic function, long - term use causes digestive problems such as loose stools, nausea, and gas in one third of patients. In addition, approximately 25 percent of patients develop gallstones, which are usually asymptomatic. In some cases, octreotide treatment can cause diabetes due to the fact that somatostatin and its analogues can inhibit the release of insulin. Dopamine agonists For those who are unresponsive to somatostatin analogues, or for whom they are otherwise contraindicated, it is possible to treat using one of the dopamine agonists, bromocriptine or cabergoline. As tablets rather than injections, they cost considerably less. These drugs can also be used as an adjunct to somatostatin analogue therapy. They are most effective in those whose pituitary tumours cosecrete prolactin. Side effects of these dopamine agonists include gastrointestinal upset, nausea, vomiting, light - headedness when standing, and nasal congestion. These side effects can be reduced or eliminated if medication is started at a very low dose at bedtime, taken with food, and gradually increased to the full therapeutic dose. However, bromocriptine lowers GH and IGF - 1 levels and reduces tumor size in fewer than half of patients with acromegaly. Some patients report improvement in their symptoms although their GH and IGF - 1 levels still are elevated. Growth hormone receptor antagonists The latest development in the medical treatment of acromegaly is the use of growth hormone receptor antagonists. The only available member of this family is pegvisomant ( Somavert ). By blocking the action of the endogenous growth hormone molecules, this compound is able to control disease activity of acromegaly in virtually all patients. Pegvisomant has to be administered subcutaneously by daily injections. Combinations of long - acting somatostatin analogues and weekly injections of pegvisomant seem to be equally effective as daily injections of pegvisomant. Surgery Surgery is a rapid and effective treatment, of which there are two alternative methods. The first method, a procedure known as endonasal transphenoidal surgery, involves the surgeon reaching the pituitary through an incision in the nasal cavity wall. The wall is reached by passing through the nostrils with microsurgical instruments. The second method is transphenoidal surgery during which an incision is made into the gum beneath the upper lip. Further incisions are made to cut through the septum to reach the nasal cavity, where the pituitary is located. Endonasal transphenoidal surgery is a less invasive procedure with a shorter recovery time than the older method of transphenoidal surgery, and the likelihood of removing the entire tumor is greater with reduced side effects. Consequently, endonasal transphenoidal surgery is often used as a first option, with transphenoidal and other treatments, such as medicinal therapy or stereotactic radiosurgery, used to reduce the remaining adverse effects of the remaining tumor. These procedures normally relieve the pressure on the surrounding brain regions and lead to a lowering of GH levels. Surgery is most successful in patients with blood GH levels below 40 ng / ml before the operation and with pituitary tumors no larger than 10 mm in diameter. Success depends on the skill and experience of the surgeon. The success rate also depends on what level of GH is defined as a cure. The best measure of surgical success is normalization of GH and IGF - 1 levels. Ideally, GH should be less than 2 ng / ml after an oral glucose load. A review of GH levels in 1,360 patients worldwide immediately after surgery revealed that 60 % had random GH levels below 5 ng / ml. Complications of surgery may include cerebrospinal fluid leaks, meningitis, or damage to the surrounding normal pituitary tissue, requiring lifelong pituitary hormone replacement. Even when surgery is successful and hormone levels return to normal, patients must be carefully monitored for years for possible recurrence. More commonly, hormone levels may improve, but not return completely to normal. These patients may then require additional treatment, usually with medications. Radiation therapy Radiation therapy has been used both as a primary treatment and combined with surgery or drugs. It is usually reserved for patients who have tumor remaining after surgery. These patients often also receive medication to lower GH levels. Radiation therapy is given in divided doses over four to six weeks. This treatment lowers GH levels by about 50 percent over 2 to 5 years. Patients monitored for more than 5 years show significant further improvement. Radiation therapy causes a gradual loss of production of other pituitary hormones with time. Loss of vision and brain injury, which have been reported, are very rare complications of radiation treatments. Choices No single treatment is effective for all patients. Treatment should be individualized depending on patient characteristics, such as age and tumor size. If the tumor has not yet invaded surrounding brain tissues, removal of the pituitary adenoma by an experienced neurosurgeon is usually the first choice. After surgery, a patient must be monitored for a long time for increasing GH levels. If surgery does not normalize hormone levels or a relapse occurs, a doctor will usually begin additional drug therapy. The current first choice is generally octreotide or lanreotide. However, bromocriptine or cabergoline are much cheaper and easier to administer. With both types of medication, long - term therapy is necessary because their withdrawal can lead to rising GH levels and tumor re-expansion. Radiation therapy is generally used for patients whose tumors are not completely removed by surgery ; for patients who are not good candidates for surgery because of other health problems ; and for patients who do not respond adequately to surgery and medication. Prognosis Upon successful treatment, symptoms and complications generally improve substantially or disappear, including headaches, visual disturbances, excess sweating, and diabetes. Soft - tissue swellings generally decrease and acromegaly - associated facial features gradually return towards normal, although this may take some time. Life expectancy after the successful treatment of early acromegaly is equal to that of the normal population. Notable cases Famous people with acromegaly include : Richard Kiel, actor, `` Jaws '' from two James Bond movies and Mr. Larson in Happy Gilmore. He grew up to 7 ft 11⁄2 in, but was slightly under 7 ft in his later years due to age and injury. Pío Pico, the last Mexican Governor of California ( 1801 -- 1894 ), manifested acromegaly without gigantism between at least 1847 and 1858. Some time after 1858, signs of the growth hormone - producing tumor disappeared along with all the secondary effects the tumor had caused in him. He looked normal in his 90s. His remarkable recovery is likely an example of spontaneous selective pituitary tumor apoplexy. Adam Rainer, born in 1899, an Austrian man, is so far the only person in recorded history to have been both a dwarf and a giant. His rapid change from dwarf to giant is believed to have been caused by acromegaly. He died on 4 March 1950. Tony Robbins, motivational speaker André the Giant ( born André Rousimoff ), French professional wrestler and actor was 2.13 m ( 7 ft ) tall after back surgery ; his original wrestling statistics listed him at 2.23 m ( 7 ft 4 in ). He died at the age of 46 and weighed 240 kilograms ( 530 lb ). ( He chose not to be treated and died from cardiac complications of acromegaly. ) Big Show ( born Paul Wight ), American professional wrestler and actor, currently working for the WWE, had his pituitary tumor removed in 1991. The Great Khali ( born Dalip Singh Rana ), Indian professional wrestler, is best known for his tenure with WWE. He had his pituitary tumor removed in 2012, aged 39. Antônio Silva, Brazilian mixed martial artist, competes in the heavyweight division of the UFC. Maurice Tillet ( 1903 - 1954 ), Russian - born French professional wrestler, is better known by his ring name, the French Angel. Carel Struycken, Dutch actor, 2.13 m ( 7 ft ), is best known for playing Lurch in The Addams Family film trilogy, The Giant in Twin Peaks, and Lwaxana Trois silent Servant Mr. Homn in Star Trek The Next Generation. Irwin Keyes, American actor. Best known for portraying Hugo Mojoloweski, George 's occasional bodyguard on The Jeffersons Paul Benedict, American actor. Best known for portraying Harry Bentley, The Jeffersons English next door neighbour Rondo Hatton, American actor. A Hollywood favorite in B - movie horror films of the 1930s and 1940s. Hatton 's disfigurement, due to acromegaly, developed over time, beginning during his service in World War I. Morteza Mehrzad, Iranian Paralympian and medalist. Member of the Iranian sitting volleyball team. Top scorer in the 2016 gold medal match. See also Hypothalamic -- pituitary -- somatic axis References Jump up ^ `` Acromegaly ''. Oxford Dictionaries. Oxford University Press. Retrieved 2016 - 01 - 20. Jump up ^ `` Acromegaly ''. Merriam - Webster Dictionary. ^ Jump up to : `` Acromegaly ''. NIDDK. April 2012. Archived from the original on 27 August 2016. Retrieved 20 August 2016. Jump up ^ Guglielmi, Giuseppe ; Kuijk, Cornelis Van ( 2001 ). 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External links Classification V T D ICD - 10 : E22. 0 inusl ICD - 9 - CM : 253.0 OMIM : 102200 MeSH : D000172 DiseasesDB : 114 External resources MedlinePlus : 000321 eMedicine : med / 27 derm / 593 Patient UK : Acromegaly Orphanet : 963 Acromegaly at Curlie ( based on DMOZ ) 2011 American Association of CLinical Endocrinologists Guideline Endocrine and Metabolic Diseases Information Service Diseases of the endocrine system ( E00 -- E35, 240 -- 259 ) Pancreas / glucose metabolism Hypofunction Diabetes mellitus types : type 1 type 2 gestational MODY 1 2 3 4 5 6 complications coma angiopathy ketoacidosis nephropathy neuropathy retinopathy cardiomyopathy insulin receptor ( Rabson -- Mendenhall syndrome ) Insulin resistance Hyperfunction Hypoglycemia beta cell ( Hyperinsulinism ) G cell ( Zollinger -- Ellison syndrome ) Hypothalamic / pituitary axes Hypothalamus gonadotropin Kallmann syndrome Adiposogenital dystrophy CRH ( Tertiary adrenal insufficiency ) vasopressin ( Neurogenic diabetes insipidus ) general ( Hypothalamic hamartoma ) Pituitary Hyperpituitarism anterior Acromegaly Hyperprolactinaemia Pituitary ACTH hypersecretion posterior ( SIADH ) general ( Nelson 's syndrome ) Hypopituitarism anterior Kallmann syndrome Growth hormone deficiency Hypoprolactinemia ACTH deficiency / Secondary adrenal insufficiency GnRH insensitivity FSH insensitivity LH / hCG insensitivity posterior ( Neurogenic diabetes insipidus ) general Empty sella syndrome Pituitary apoplexy Sheehan 's syndrome Lymphocytic hypophysitis Thyroid Hypothyroidism Iodine deficiency Cretinism Congenital hypothyroidism Myxedema Euthyroid sick syndrome Hyperthyroidism Hyperthyroxinemia Thyroid hormone resistance Familial dysalbuminemic hyperthyroxinemia Hashitoxicosis Thyrotoxicosis factitia Graves ' disease Thyroiditis Acute infectious Subacute De Quervain 's Subacute lymphocytic Autoimmune / chronic Hashimoto 's Postpartum Riedel 's Goitre Endemic goitre Toxic nodular goitre Toxic multinodular goiter Thyroid nodule Parathyroid Hypoparathyroidism Pseudohypoparathyroidism Pseudopseudohypoparathyroidism Hyperparathyroidism Primary Secondary Tertiary Osteitis fibrosa cystica Adrenal Hyperfunction aldosterone : Hyperaldosteronism / Primary aldosteronism Conn syndrome Bartter syndrome Glucocorticoid remediable aldosteronism AME Liddle 's syndrome 17α CAH cortisol : Cushing 's syndrome ( Pseudo-Cushing's syndrome ) sex hormones : 21α CAH 11β CAH Hypofunction / Adrenal insufficiency ( Addison 's, WF ) aldosterone : Hypoaldosteronism 21α CAH 11β CAH cortisol : CAH Lipoid 3β 11β 17α 21α sex hormones : 17α CAH Gonads ovarian : Polycystic ovary syndrome Premature ovarian failure testicular : enzymatic 5α - reductase deficiency 17β - hydroxysteroid dehydrogenase deficiency aromatase excess syndrome Androgen receptor ( Androgen insensitivity syndrome ) general : Hypogonadism ( Delayed puberty ) Hypergonadism Precocious puberty Hypoandrogenism Hypoestrogenism Hyperandrogenism Hyperestrogenism Postorgasmic illness syndrome Height Dwarfism / Short stature Midget Laron syndrome Psychosocial Ateliosis Gigantism Multiple Autoimmune polyendocrine syndrome multiple APS1 APS2 Carcinoid syndrome Multiple endocrine neoplasia 2A 2B Progeria Werner syndrome Acrogeria Metageria Woodhouse -- Sakati syndrome NDL : 01150006 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Acromegaly&oldid=827504340 '' Categories : Endocrine - related cutaneous conditions Growth disorders Growth hormones Neuroendocrinology Pituitary disorders Hidden categories : Webarchive template wayback links Infobox medical condition ( new ) Articles containing Ancient Greek - language text Articles with Curlie links RTT RTTNEURO Talk Contents About Wikipedia Afrikaans Asturianu Беларуская Български Català Čeština Cymraeg Dansk Deutsch ދިވެހިބަސް Ελληνικά Español Euskara فارسی Français Gaeilge Galego 한국어 Հայերեն Hrvatski Bahasa Indonesia Italiano עברית Қазақша Latviešu Lietuvių Magyar Македонски മലയാളം Nederlands 日本 語 Norsk ଓଡ଼ିଆ Oʻzbekcha / ўзбекча Polski Português Română Русский Sardu Scots Shqip Simple English Slovenčina Slovenščina Српски / srpski Suomi Svenska Tagalog ไทย Türkçe Українська 粵語 中文 45 more Edit links This page was last edited on 25 February 2018, at 02 : 53. 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Question: acromegly is a disorder due to chronically high levels of
Answer: growth hormone