Medicinal chemistry - wikipedia Medicinal chemistry Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules ( drugs ). Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules ( e.g., atorvastatin, fluticasone, clopidogrel ) and `` biologics '' ( infliximab, erythropoietin, insulin glargine ), the latter of which are most often medicinal preparations of proteins ( natural and recombinant antibodies, hormones, etc. ). Inorganic and organometallic compounds are also useful as drugs ( e.g., lithium and platinum - based agents such as lithium carbonate and cis - platin as well as gallium ). In particular, medicinal chemistry in its most common practice -- focusing on small organic molecules -- encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology and structural biology, together aiming at the discovery and development of new therapeutic agents. Practically speaking, it involves chemical aspects of identification, and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use. It includes synthetic and computational aspects of the study of existing drugs and agents in development in relation to their bioactivities ( biological activities and properties ), i.e., understanding their structure - activity relationships ( SAR ). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for purpose of medicinal products. At the biological interface, medicinal chemistry combines to form a set of highly interdisciplinary sciences, setting its organic, physical, and computational emphases alongside biological areas such as biochemistry, molecular biology, pharmacognosy and pharmacology, toxicology and veterinary and human medicine ; these, with project management, statistics, and pharmaceutical business practices, systematically oversee altering identified chemical agents such that after pharmaceutical formulation, they are safe and efficacious, and therefore suitable for use in treatment of disease. Contents 1 In the path of drug discovery 1.1 Discovery 1.2 Hit to lead and lead optimization 1.3 Process chemistry and development 2 Training 3 See also 4 References 5 External links In the path of drug discovery Discovery Discovery is the identification of novel active chemical compounds, often called `` hits '', which are typically found by assay of compounds for a desired biological activity. Initial hits can come from repurposing existing agents toward a new pathologic processes, and from observations of biologic effects of new or existing natural products from bacteria, fungi, plants, etc. In addition, hits also routinely originate from structural observations of small molecule `` fragments '' bound to therapeutic targets ( enzymes, receptors, etc. ), where the fragments serve as starting points to develop more chemically complex forms by synthesis. Finally, hits also regularly originate from en - masse testing of chemical compounds against biological targets, where the compounds may be from novel synthetic chemical libraries known to have particular properties ( kinase inhibitory activity, diversity or drug - likeness, etc. ), or from historic chemical compound collections or libraries created through combinatorial chemistry. While a number of approaches toward the identification and development of hits exist, the most successful techniques are based on chemical and biological intuition developed in team environments through years of rigorous practice aimed solely at discovering new therapeutic agents. Hit to lead and lead optimization See also : Lead optimization Further chemistry and analysis is necessary, first to identify the `` triage '' compounds that do not provide series displaying suitable SAR and chemical characteristics associated with long - term potential for development, then to improve remaining hit series with regard to the desired primary activity, as well as secondary activities and physiochemical properties such that the agent will be useful when administered in real patients. In this regard, chemical modifications can improve the recognition and binding geometries ( pharmacophores ) of the candidate compounds, and so their affinities for their targets, as well as improving the physicochemical properties of the molecule that underlie necessary pharmacokinetic / pharmacodynamic ( PK / PD ), and toxicologic profiles ( stability toward metabolic degradation, lack of geno -, hepatic, and cardiac toxicities, etc. ) such that the chemical compound or biologic is suitable for introduction into animal and human studies. Process chemistry and development The final synthetic chemistry stages involve the production of a lead compound in suitable quantity and quality to allow large scale animal testing, and then human clinical trials. This involves the optimization of the synthetic route for bulk industrial production, and discovery of the most suitable drug formulation. The former of these is still the bailiwick of medicinal chemistry, the latter brings in the specialization of formulation science ( with its components of physical and polymer chemistry and materials science ). The synthetic chemistry specialization in medicinal chemistry aimed at adaptation and optimization of the synthetic route for industrial scale syntheses of hundreds of kilograms or more is termed process synthesis, and involves thorough knowledge of acceptable synthetic practice in the context of large scale reactions ( reaction thermodynamics, economics, safety, etc. ). Critical at this stage is the transition to more stringent GMP requirements for material sourcing, handling, and chemistry. Training Medicinal chemistry is by nature an interdisciplinary science, and practitioners have a strong background in organic chemistry, which must eventually be coupled with a broad understanding of biological concepts related to cellular drug targets. Scientists in medicinal chemistry work are principally industrial scientists ( but see following ), working as part of an interdisciplinary team that uses their chemistry abilities, especially, their synthetic abilities, to use chemical principles to design effective therapeutic agents. The length of training is intense with practitioners often required to attain a 4 - year bachelor 's followed by a 4 - 6 year Ph. D. in organic chemistry. Most training regimens include a postdoctoral fellowship period of 2 or more years after receiving a Ph. D. in chemistry making the length of training ranging from 10 - 12 years of college education. However, employment opportunities at the Master 's level also exist in the pharmaceutical industry, and at that and the Ph. D. level there are further opportunities for employment in academia and government. Many medicinal chemists, particularly in academia and research, also earn a Pharm. D ( doctor of pharmacy ). Some of these PharmD / PhD researchers are RPhs ( Registered Pharmacists ). Graduate level programs in medicinal chemistry can be found in traditional medicinal chemistry or pharmaceutical sciences departments, both of which are traditionally associated with schools of pharmacy, and in some chemistry departments. However, the majority of working medicinal chemists have graduate degrees ( MS, but especially Ph. D. ) in organic chemistry, rather than medicinal chemistry, and the preponderance of positions are in discovery, where the net is necessarily cast widest, and most broad synthetic activity occurs. In discovery of small molecule therapeutics, an emphasis on training that provides for breadth of synthetic experience and `` pace '' of bench operations is clearly present ( e.g., for individuals with pure synthetic organic and natural products synthesis in Ph. D. and post-doctoral positions, ibid. ). In the medicinal chemistry specialty areas associated with the design and synthesis of chemical libraries or the execution of process chemistry aimed at viable commercial syntheses ( areas generally with fewer opportunities ), training paths are often much more varied ( e.g., including focused training in physical organic chemistry, library - related syntheses, etc. ). As such, most entry - level workers in medicinal chemistry, especially in the U.S., do not have formal training in medicinal chemistry but receive the necessary medicinal chemistry and pharmacologic background after employment -- at entry into their work in a pharmaceutical company, where the company provides its particular understanding or model of `` medichem '' training through active involvement in practical synthesis on therapeutic projects. ( The same is somewhat true of computational medicinal chemistry specialties, but not to the same degree as in synthetic areas. ) See also Pharmacy and Pharmacology portal Chemistry portal Science portal Bioisostere Biological machines Drug design Pharmacognosy Pharmacokinetics Pharmacology Pharmacophore Xenobiotic metabolism References Jump up ^ Hughes, Jp ; Rees, S ; Kalindjian, Sb ; Philpott, Kl ( 2011 - 03 - 01 ). `` Principles of early drug discovery ''. British Journal of Pharmacology. 162 ( 6 ) : 1239 -- 1249. ISSN 1476 - 5381. PMC 3058157. PMID 21091654. doi : 10.1111 / j. 1476 - 5381.2010. 01127. x. Jump up ^ Johnston, Kelly L. ; Ford, Louise ; Umareddy, Indira ; Townson, Simon ; Specht, Sabine ; Pfarr, Kenneth ; Hoerauf, Achim ; Altmeyer, Ralf ; Taylor, Mark J. ( 2014 - 12 - 01 ). `` Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis ''. International Journal for Parasitology : Drugs and Drug Resistance. Includes articles from two meetings : `` Anthelmintics : From Discovery to Resistance '', pp. 218 -- 315, and `` Global Challenges for New Drug Discovery Against Tropical Parasitic Diseases '', pp. 316 -- 357. 4 ( 3 ) : 278 -- 286. PMC 4266796. PMID 25516838. doi : 10.1016 / j. ijpddr. 2014.09. 001. Jump up ^ Harvey, Alan L. ( 2008 - 10 - 01 ). `` Natural products in drug discovery ''. Drug Discovery Today. 13 ( 19 -- 20 ) : 894 -- 901. PMID 18691670. doi : 10.1016 / j. drudis. 2008.07. 004. Jump up ^ Cragg, Gordon M. ; Newman, David J. ( 2013 - 06 - 01 ). `` Natural products : A continuing source of novel drug leads ''. Biochimica et Biophysica Acta ( BBA ) - General Subjects. 1830 ( 6 ) : 3670 -- 3695. PMC 3672862. PMID 23428572. doi : 10.1016 / j. bbagen. 2013.02. 008. Jump up ^ `` Careers for 2003 and Beyond : Medicinal Chemistry ''. Chemical & Engineering News. 81 ( 25 ) : 53 -- 54, 56. External links Look up medicinal chemistry in Wiktionary, the free dictionary. Biochemistry and Molecular Biology at DMOZ Topics in medicinal chemistry ADME Bioavailability Chemogenomics Drug class Drug delivery Drug design Drug discovery Drug targeting Enzyme inhibitor Ligand efficiency Mechanism of action Mode of action New chemical entity Pharmacodynamics Pharmacokinetics Pharmacology Pharmacophore Quantitative structure - activity relationship Branches of chemistry Dictionary of chemical formulas List of biomolecules List of inorganic compounds Periodic table Physical Chemical kinetics Chemical physics Nuclear chemistry Electrochemistry Femtochemistry Geochemistry Photochemistry Quantum chemistry Solid - state chemistry Spectroscopy Surface science Thermochemistry Organic Biochemistry Bioorganic chemistry Biophysical chemistry Chemical biology Clinical chemistry Fullerene chemistry Medicinal chemistry Neurochemistry Pharmacy Physical organic chemistry Polymer chemistry Inorganic Bioinorganic chemistry Cluster chemistry Coordination chemistry Materials science Organometallic chemistry Others Actinide chemistry Analytical chemistry Astrochemistry Chemistry education Clay chemistry Click chemistry Computational chemistry Cosmochemistry Environmental chemistry Food chemistry Forensic chemistry Green chemistry Post-mortem chemistry Supramolecular chemistry Theoretical chemistry Wet chemistry Portal Commons WikiProject Retrieved from `` https://en.wikipedia.org/w/index.php?title=Medicinal_chemistry&oldid=801330190 '' Categories : Medicinal chemistry Cheminformatics Hidden categories : All articles with unsourced statements Articles with unsourced statements from June 2011 Articles with DMOZ links Articles prone to spam from August 2014 Talk Contents About Wikipedia Български Bosanski Deutsch Español فارسی 한국어 Bahasa Indonesia ಕನ್ನಡ Magyar Македонски Nederlands 日本 語 Norsk Polski Português Русский Simple English کوردی Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska Tagalog ไทย Türkçe Українська Tiếng Việt 中文 Edit links This page was last edited on 19 September 2017, at 01 : 33. 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Question: application of chemistry in the field of medicine
Answer: design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs)