Cherry hemangioma - wikipedia Cherry hemangioma Cherry angioma A cherry angioma Classification and external resources Specialty cardiology ICD - 9 - CM 448.1 DiseasesDB 30744 MedlinePlus 001441 eMedicine derm / 73 ( edit on Wikidata ) Cherry angiomas, also known as Campbell De Morgan spots or senile angiomas, are cherry red papules on the skin containing an abnormal proliferation of blood vessels. They are the most common kind of angioma. They are called Campbell de Morgan spots after the nineteenth - century British surgeon Campbell De Morgan, who first noted and described them. The frequency of cherry angiomas increases with age. Contents 1 Signs and symptoms 2 Cause 3 Diagnosis 4 Treatment 5 Prognosis 6 Epidemiology 7 References 8 External links Signs and Symptoms Cherry hemangioma, H&E stain Cherry angiomas are made up of clusters of capillaries at the surface of the skin, forming a small round dome ( `` papule '' ), which may be flat topped. They range in colour from bright red to purple. When they first develop, they may be only a tenth of a millimeter in diameter and almost flat, appearing as small red dots. However, they then usually grow to about one or two millimeters across, and sometimes to a centimeter or more in diameter. As they grow larger, they tend to expand in thickness, and may take on the raised and rounded shape of a dome. Multiple adjoining angiomas are said to form a polypoid angioma. Because the blood vessels comprising an angioma are so close to the skin 's surface, cherry angiomas may bleed profusely if they are injured. One study found that the majority of capillaries in cherry hemangiomas are fenestrated because of staining for carbonic anhydrase activity. Cause Cherry angiomas appear spontaneously in many people in middle age but can also, less commonly, occur in young people. They can also occur in an aggressive eruptive manner in any age. The underlying cause for the development of cherry angiomas is not understood. Findings suggest that cherry angioma may occur through two different mechanisms : angiogenesis ( the formation of new blood vessels from pre-existing vessels ), and vasculogenesis ( the formation of totally new vessels, which usually occurs during embryonic and fetal development ). The first study trying to bring light to the molecular and genetic mechanisms behind cherry / senile hemangioma was published in 2010. The study found that the level of microRNA 424 is significantly reduced in senile hemangiomas compared to normal skin resulting in increased protein expression of MEK1 and cyclin E1. By inhibiting mir - 424 in normal endothelial cells they could observe the same increased protein expression of MEK1 and cyclin E1 which, important for the development of senile hemangioma, induced cell proliferation of the endothelial cells. They also found that targeting MEK1 and cyclin E1 with small interfering RNA decreased the number of endothelial cells. Chemicals and compounds that have been seen to cause cherry angiomas are mustard gas, 2 - butoxyethanol, bromides, and cyclosporine. A significant increase in the density of mast cells has been seen in cherry hemangiomas compared with normal skin. Diagnosis This section is empty. You can help by adding to it. ( April 2017 ) Treatment These lesions generally do not require treatment. If they are cosmetically unappealing or are subject to bleeding angiomas may be removed by electrocautery, a process of destroying the tissue by use of a small probe with an electric current running through it. Removal may cause scarring. More recently pulsed dye laser or intense pulsed light ( IPL ) treatment has also been used. Future treatment based on a locally acting inhibitor of MEK1 and Cyclin E1 could possibly be an option. A natural MEK1 inhibitor is myricetin Prognosis In most patients, the number and size of cherry angiomas increases with advancing age. They are harmless, having no relation to cancer at all. Epidemiology Cherry angiomas occur in all races, ethnic backgrounds, and sexes. References Jump up ^ James, William ; Berger, Timothy ; Elston, Dirk ( 2006 ). Andrews ' Diseases of the Skin : Clinical Dermatology ( 10th ed. ). Philadelphia : Saunders. p. 595. ISBN 978 - 0 - 7216 - 2921 - 6. OCLC 62736861. Jump up ^ `` cherry angioma '' at Dorland 's Medical Dictionary Jump up ^ Eichhorn, M ; Jungkunz, W ; Wörl, J ; Marsch, WC ( 1994 ). `` Carbonic anhydrase is abundant in fenestrated capillaries of cherry hemangioma ''. Acta dermato - venereologica. 74 ( 1 ) : 51 -- 3. PMID 7908484. Jump up ^ Kishimoto,, Saburo ; Hideya Takenaka ; Hideya Takenaka ; Hideya Takenaka ; Hirokazu Yasuno ( 2000 ). `` Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells ''. Cutaneous Pathology. Jump up ^ Nakashima, T ; Jinnin, M ; Etoh, T ; Fukushima, S ; Masuguchi, S ; Maruo, K ; Inoue, Y ; Ishihara, T ; Ihn, H ( 2010 ). Egles, Christophe, ed. `` Down - regulation of mir - 424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma : its implications to therapy ''. PLoS ONE. 5 ( 12 ) : e14334. PMC 3001869. PMID 21179471. doi : 10.1371 / journal. pone. 0014334. Jump up ^ Firooz, Alireza ; Komeili, Ali ; Dowlati, Yahya ( 1999 ). `` Eruptive melanocytic nevi and cherry angiomas secondary to exposureto sulfur mustard gas ''. Journal of the American Academy of Dermatology. 40 ( 4 ) : 646 -- 7. PMID 10188695. doi : 10.1016 / S0190 - 9622 ( 99 ) 70460 - 3. Jump up ^ Hefazi, Mehrdad ; Maleki, Masoud ; Mahmoudi, Mahmoud ; Tabatabaee, Abbas ; Balali - Mood, Mahdi ( 2006 ). `` Delayed complications of sulfur mustard poisoning in the skin and the immune system of Iranian veterans 16 -- 20 years after exposure ''. International Journal of Dermatology. 45 ( 9 ) : 1025 -- 31. PMID 16961503. doi : 10.1111 / j. 1365 - 4632.2006. 03020. x. Jump up ^ Ma, Hui - Jun ; Zhao, Guang ; Shi, Fei ; Wang, Yi - Xia ( 2006 ). `` Eruptive cherry angiomas associated with vitiligo : Provoked by topical nitrogen mustard ? ''. The Journal of Dermatology. 33 ( 12 ) : 877 -- 9. PMID 17169094. doi : 10.1111 / j. 1346 - 8138.2006. 00200. x. Jump up ^ Emadi, Seyed Naser ; Hosseini - Khalili, Alireza ; Soroush, Mohammad Reza ; Davoodi, Seyed Masoud ; Aghamiri, Seyed Samad ( 2008 ). `` Mustard gas scarring with specific pigmentary, trophic and vascular characteristics ( case report, 16 - year post-exposure ) ''. Ecotoxicology and Environmental Safety. 69 ( 3 ) : 574 -- 6. PMID 17382390. doi : 10.1016 / j. ecoenv. 2007.01. 003. Jump up ^ Raymond, Lawrence W. ; Williford, Linda S. ; Burke, William A. ( 1998 ). `` Eruptive Cherry Angiomas and Irritant Symptoms After One Acute Exposure to the Glycol Ether Solvent 2 - Butoxyethanol ''. Journal of Occupational & Environmental Medicine : 1059 -- 64. doi : 10.1097 / 00043764 - 199812000 - 00005. Jump up ^ Cohen, Arnon D. ; Cagnano, Emanuela ; Vardy, Daniel A. ( 2001 ). `` Cherry Angiomas Associated with Exposure to Bromides ''. Dermatology. 202 ( 1 ) : 52 -- 3. PMID 11244231. doi : 10.1159 / 000051587. Jump up ^ De Felipe, I. ; Redondo, P ( 1998 ). `` Eruptive Angiomas After Treatment With Cyclosporine in a Patient With Psoriasis ''. Archives of Dermatology. 134 ( 11 ) : 1487 -- 8. PMID 9828895. doi : 10.1001 / archderm. 134.11. 1487. Jump up ^ Hagiwara, K ; Khaskhely, NM ; Uezato, H ; Nonaka, S ( 1999 ). `` Mast cell `` densities '' in vascular proliferations : a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi 's sarcoma, and malignant hemangioendothelioma ``. The Journal of dermatology. 26 ( 9 ) : 577 -- 86. PMID 10535252. Jump up ^ Aversa, AJ ; Miller Of, 3rd ( 1983 ). `` Cryo - curettage of cherry angiomas ''. The Journal of dermatologic surgery and oncology. 9 ( 11 ) : 930 -- 1. PMID 6630708. doi : 10.1111 / j. 1524 - 4725.1983. tb01042. x. Jump up ^ Dawn, G. ; Gupta, G. ( 2003 ). `` Comparison of potassium titanyl phosphate vascular laser and hyfrecator in the treatment of vascular spiders and cherry angiomas ''. Clinical and Experimental Dermatology. 28 ( 6 ) : 581 -- 3. PMID 14616818. doi : 10.1046 / j. 1365 - 2230.2003. 01352. x. Jump up ^ Fodor, Lucian ; Ramon, Ytzhack ; Fodor, Adriana ; Carmi, Nurit ; Peled, Isaac J. ; Ullmann, Yehuda ( 2006 ). `` A Side - by - Side Prospective Study of Intense Pulsed Light and Nd : YAG Laser Treatment for Vascular Lesions ''. Annals of Plastic Surgery. 56 ( 2 ) : 164 -- 70. PMID 16432325. doi : 10.1097 / 01. sap. 0000196579.14954. d6. Jump up ^ Lee, KW ; Kang, NJ ; Rogozin, EA ; Kim, HG ; Cho, YY ; Bode, AM ; Lee, HJ ; Surh, YJ ; et al. ( 2007 ). `` Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1 ''. Carcinogenesis. 28 ( 9 ) : 1918 -- 27. PMID 17693661. doi : 10.1093 / carcin / bgm110. Jump up ^ Kim, JE ; Kwon, JY ; Lee, DE ; Kang, NJ ; Heo, YS ; Lee, KW ; Lee, HJ ( 2009 ). `` MKK4 is a novel target for the inhibition of tumor necrosis factor - alpha - induced vascular endothelial growth factor expression by myricetin ''. Biochemical pharmacology. 77 ( 3 ) : 412 -- 21. PMID 19026990. doi : 10.1016 / j. bcp. 2008.10. 027. Jump up ^ http://www.livestrong.com/article/398110-cherry-angioma-skin-cancer/ External links Netdoctor UK Dr John Pillinger. GP HealthScout FPNotebook MedSapiens eMedicine with picture showing small red dots Pereira, José Marcos ( 2004 ). `` Hemangioma rubi no couro cabeludo ''. Anais Brasileiros de Dermatologia. 79. doi : 10.1590 / S0365 - 05962004000100010. Cardiovascular disease ( vessels ) ( I70 -- I99, 440 -- 456 ) Arteries, arterioles and capillaries Inflammation Arteritis Aortitis Buerger 's disease Peripheral artery disease Arteriosclerosis Atherosclerosis Foam cell Fatty streak Atheroma Intermittent claudication Critical limb ischemia Monckeberg 's arteriosclerosis Arteriolosclerosis Hyaline Hyperplastic Cholesterol LDL Oxycholesterol Trans fat Stenosis Carotid artery stenosis Renal artery stenosis Other Aortoiliac occlusive disease Degos disease Erythromelalgia Fibromuscular dysplasia Raynaud 's phenomenon Aneurysm / dissection / pseudoaneurysm torso : Aortic aneurysm Abdominal aortic aneurysm Thoracic aortic aneurysm Aneurysm of sinus of Valsalva Aortic dissection Coronary artery aneurysm head / neck Intracranial aneurysm Intracranial berry aneurysm Carotid artery dissection Vertebral artery dissection Familial aortic dissection Vascular malformation Arteriovenous fistula Arteriovenous malformation Telangiectasia Hereditary hemorrhagic telangiectasia Vascular nevus Cherry hemangioma Halo nevus Spider angioma Veins Inflammation Phlebitis Venous thrombosis / Thrombophlebitis primarily lower limb Deep vein thrombosis abdomen Hepatic veno - occlusive disease Budd -- Chiari syndrome May -- Thurner syndrome Portal vein thrombosis Renal vein thrombosis upper limb / torso Mondor 's disease Paget -- Schroetter disease head Cerebral venous sinus thrombosis Post-thrombotic syndrome Varicose veins Gastric varices Portacaval anastomosis Caput medusae Esophageal varices Hemorrhoid Varicocele Other Chronic venous insufficiency Chronic cerebrospinal venous insufficiency Superior vena cava syndrome Inferior vena cava syndrome Venous ulcer Arteries or veins Angiopathy Macroangiopathy Microangiopathy Embolism Pulmonary embolism Cholesterol embolism Paradoxical embolism Thrombosis Vasculitis Blood pressure Hypertension Hypertensive heart disease Hypertensive emergency Hypertensive nephropathy Essential hypertension Secondary hypertension Renovascular hypertension Benign hypertension Pulmonary hypertension Systolic hypertension White coat hypertension Hypotension Orthostatic hypotension Retrieved from `` https://en.wikipedia.org/w/index.php?title=Cherry_hemangioma&oldid=798446987 '' Categories : Dermal and subcutaneous growths Hidden categories : All articles with unsourced statements Articles with unsourced statements from January 2015 Articles to be expanded from April 2017 All articles to be expanded Articles with empty sections from April 2017 All articles with empty sections Articles using small message boxes Talk Contents About Wikipedia Français Polski Edit links This page was last edited on 2 September 2017, at 00 : 49. 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Question: what causes red blood filled spots on skin
Answer: angiogenesis (the formation of new blood vessels from pre-existing vessels)