Blister - wikipedia Blister For other uses, see Blister ( disambiguation ). `` Vesiculation '' redirects here. For vesiculation in geology, see vesicular texture. Blister Blister on foot caused by friction. Classification and external resources Specialty Dermatology ICD - 10 T14. 0 ICD - 9 - CM 919.2 DiseasesDB 1777 MedlinePlus 003239 Patient UK Blister MeSH D001768 ( edit on Wikidata ) A blister is a small pocket of body fluid ( lymph, serum, plasma, blood, or pus ) within the upper layers of the skin, typically caused by forceful rubbing ( friction ), burning, freezing, chemical exposure or infection. Most blisters are filled with a clear fluid, either serum or plasma. However, blisters can be filled with blood ( known as `` blood blisters '' ) or with pus ( for instance, if they become infected ). The word `` blister '' entered English in the 14th century. It came from the Middle Dutch `` bluyster '' and was a modification of the Old French `` blostre '', which meant a leprous nodule -- a rise in the skin due to leprosy. In dermatology today, the words vesicle and bulla refer to blisters of smaller or greater size, respectively. To heal properly, a blister should not be popped unless medically necessary. If popped, the excess skin should not be removed because the skin underneath needs that top layer to heal properly. Contents 1 Causes 1.1 Friction or rubbing 1.2 Extreme temperature 1.3 Chemical exposure 1.4 Crushing / pinching 1.5 Medical conditions 2 Pathophysiology 2.1 Friction blisters 3 Prevention 3.1 Friction blisters 3.2 Other 4 References 5 External links Causes A blister may form when the skin has been damaged by friction or rubbing, heat, cold or chemical exposure. Fluid collects between the epidermis -- the upper layer of the skin -- and the layers below. This fluid cushions the tissue underneath, protecting it from further damage and allowing it to heal. Friction or rubbing Picture of various size blisters on the sole of a foot due to friction. Intense rubbing can cause a blister, as can any friction on the skin if continued long enough. This kind of blister is most common after walking long distances or by wearing old or poorly fitting shoes. Blisters are most common on the hands and feet, as these extremities are susceptible while walking, running, or performing repetitive motions, such as joystick manipulation whilst playing certain video games, digging with a shovel, playing guitar, etc. Blisters form more easily on moist skin than on dry or soaked skin, and are more common in warm conditions. Less - aggressive rubbing over long periods of time may cause calluses to form rather than a blister. Both blisters and calluses can lead to more serious complications, such as foot ulceration and infection, particularly when sensation or circulation is impaired, as in the case of diabetes, neuropathy or peripheral artery disease ( PAD ). Extreme temperature A blister caused by burning. This type of blistering is one of the tools used to determine the degree of burns sustained. First and second degree burns may result in blistered skin ; however, it is characteristic of second degree burns to blister immediately, whereas first degree burns can have blisters after a couple of days. Blisters can also form on the hands and feet as a result of tissue damage incurred by frostbite. Chemical exposure Blisters caused by exposure to sulfur mustard agent. Sometimes, the skin will blister when it comes into contact with a cosmetic, detergent, solvent, or other chemical such as nickel sulfate, Balsam of Peru, or urushiol ( poison ivy, poison oak, poison sumac ). This is known as contact dermatitis. Blisters can also develop as a result of an allergic reaction to an insect bite or sting. Some chemical warfare agents, known as blister agents or vesicants, cause large, painful blisters wherever they contact skin ; an example is mustard gas. Crushing / pinching A blood blister usually forms when a minute blood vessel close to the surface of the skin ruptures ( breaks ), and blood leaks into a tear between the layers of skin. This can happen if the skin is crushed, pinched or aggressively squeezed. Medical conditions There are also a number of medical conditions that cause blisters. The most common are chickenpox, herpes, impetigo, and a form of eczema called dyshidrosis. Other, much rarer conditions that cause blisters include : Bullous pemphigoid : a skin disease that causes large, tightly filled blisters to develop, usually affecting people over the age of 60. Pemphigus : a serious skin disease in which blisters develop if pressure is applied to the skin ; the blisters burst easily, leaving raw areas that can become infected. Dermatitis herpetiformis : a skin disease that causes intensely itchy blisters, usually on the elbows, knees, back and buttocks. The blisters usually develop in patches of the same shape and size on both sides of the body. Chronic bullous dermatosis : a disease that causes clusters of blisters on the face, mouth or genitals. Cutaneous radiation syndrome Epidermolysis bullosa Pathophysiology Friction blisters Friction blisters are caused by excess shear stress between the surface of the skin and the body. The strata of skin around the Stratum spinosum are most susceptible to shear. As the Stratum spinosum tears away from the connecting tissues below, plasma from the cells diffuses out. This plasma solution helps new cells divide and grow into new connective tissues and epidermal layers. The clear fluid will be reabsorbed as new cells develop and the swollen appearance will subside. Painful blisters located on hands ( palmar surface ) and feet ( plantar surface ) are due to tissue shearing deeper in the epidermis, near nerve endings. Lower tissues are more susceptible to infection. Prevention Friction blisters Friction blisters, caused by rubbing against the skin, can be prevented by reducing the friction to a level where blisters will not form. This can be accomplished in a variety of ways. Blisters on the feet can be prevented by wearing comfortable, well - fitting shoes and clean socks. Inherently ill - fitting or stiffer shoes, such as high heels and dress shoes, present a larger risk of blistering. Blisters are more likely to develop on skin that is moist, so socks that manage moisture or frequent sock changes will aid those with particularly sweaty feet. While exercising or playing sports, special sports socks can help keep feet drier and reduce the chance of blisters. Before going for a long walk, it is also important to ensure that shoes or hiking boots have been properly broken in. Even before a `` hot '' or irritated area on the foot is felt, taping a protective layer of padding or a friction - reducing interface between the affected area and the footwear can prevent the formation of a blister. Bandages, moleskin and tapes generally must be applied to the foot daily, and most have a very high coefficient of friction ( COF ), but a friction - management patch applied to the shoe will remain in place much longer, throughout many changes of socks and insoles. This type of intervention may be used with footwear that is worn daily, with specialty shoes and boots like hockey skates, ice skates, inline skates, ski boots and cleats, or even with orthotic braces and splints. For periods of sustained use such as hiking and trail running, especially where water ingress or moisture build up in the shoe or boot can occur, moisture wicking liner socks can provide the required friction protection. To avoid friction blisters on the hands, gloves should be worn when using tools such as a shovel or pickaxe, doing manual work such as gardening, or using sports equipment like golf clubs or baseball bats. Oars used for competitive rowing are known for causing frequent blisters on the hands of oarsmen. Weightlifters are also prone to blisters as are gymnasts from the friction developed by the rubbing against the bars. To further reduce the occurrence one can tape the hands, and there are also a number of products on the market that claim to reduce the occurrence of blisters. These are all intended to be worn as a liner underneath a glove. The majority of these offerings simply add padding and create a layer that reduces the coefficient of friction between the skin and the glove. A lubricant, typically talcum powder, can be used to reduce friction between skin and apparel in the short term. People put talcum powder inside gloves or shoes for this purpose, although this type of lubricant will increase the friction in the long term, as it absorbs moisture. Increased friction makes blisters more likely. Other Sunscreen and protective clothing should also be used during the hottest part of the day to avoid blisters from sunburn. Avoiding sunlight during midday is the best way to avoid blisters from sunburn. Protective gloves should be worn when handling detergents, cleaning products, solvents and other chemicals. References Jump up ^ Uchinuma, E ; Koganei, Y ; Shioya, N ; Yoshizato, K ( 1988 ). `` Biological evaluation of burn blister fluid ''. Annals of Plastic Surgery. 20 ( 3 ) : 225 -- 30. doi : 10.1097 / 00000637 - 198803000 - 00005. PMID 3358612. Jump up ^ `` Blister Treatments and Prevention ''. WebMD. Retrieved 2017 - 03 - 04. ^ Jump up to : ( Naylor PFD. `` The Skin Surface and Friction, '' British Journal of Dermatology. 1955 ; 67 : 239 -- 248. ) ^ Jump up to : ( Naylor PFD. `` Experimental Friction Blisters, '' British Journal of Dermatology. 1955 ; 67 : 327 -- 342. ) ^ Jump up to : ( Sulzberger MB, Cortese TA, Fishman L, Wiley HS. `` Studies on Blisters Produced by Friction, '' Journal of Investigative Dermatology. 1966 ; 47 : 456 -- 465. ) Jump up ^ ( Carlson JM. `` The Friction Factor, '' OrthoKinetic Review. Nov / Dec 2001 ; 1 ( 7 ) : 1 -- 3. ) Jump up ^ `` First Degree Burns ''. Uuhsc.utah.edu. Archived from the original on 2012 - 02 - 18. Retrieved 2012 - 02 - 21. Jump up ^ `` Conn 's Current Therapy 2011 ''. google.com. Jump up ^ http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm049342.htm Jump up ^ ( Hanna T, Carlson JM. `` Freedom from Friction, '' OrthoKinetic Review. Mar / Apr 2004 ; 4 ( 2 ) : 34 -- 35. ) Jump up ^ `` Treatment Skin Blisters -- Blister On Bottom Of Foot -- Blister On Foot ''. Goengo.com. Archived from the original on 2012 - 03 - 12. Retrieved 2012 - 02 - 21. Jump up ^ `` Adventure Medical Kit Blister Medic Gel - BackpackGearTest.org ''. backpackgeartest.org. External links Media related to blisters at Wikimedia Commons The dictionary definition of blister at Wiktionary General wounds and injuries ( T08 - T35, 870 - 949 ) Abrasions Abrasion Avulsion Blisters Blood blister Coma blister Delayed blister Edema blister Fracture blister Friction blister Sucking blister Bruises Hematoma / Ecchymosis Battle 's sign Raccoon eyes Black eye Subungual hematoma Cullen 's sign Grey Turner 's sign Retroperitoneal hemorrhage Animal bites Insect bite Spider bite Snakebite Other : Ballistic trauma Stab wound Blunt trauma / superficial / closed Penetrating trauma / open Aerosol burn Burn / Corrosion / Chemical burn Frostbite Occupational injuries Traumatic amputation By region Hand injury Head injury Chest trauma Abdominal trauma Retrieved from `` https://en.wikipedia.org/w/index.php?title=Blister&oldid=839647077 '' Categories : Skin conditions resulting from physical factors Radiation health effects Hidden categories : Infobox medical condition Commons category with local link different than on Wikidata Talk Contents About Wikipedia Avañe'ẽ Авар Aymar aru Bân - lâm - gú Català Čeština Dansk Deutsch Eesti Ελληνικά Español Esperanto Euskara فارسی Français Frysk 한국어 Հայերեն Italiano עברית Лакку Lëtzebuergesch Bahasa Melayu Nederlands 日本 語 Norsk Norsk nynorsk Oʻzbekcha / ўзбекча Polski Português Runa Simi Simple English Ślůnski Suomi Tagalog తెలుగు Українська West - Vlams 粵語 中文 32 more Edit links This page was last edited on 4 May 2018, at 19 : 22. 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Question: where does the fluid from a blister come from
Answer: between the epidermis—the upper layer of the skin—and the layers below