Insulin shock therapy - wikipedia Insulin shock therapy Insulin shock therapy Insulin shock therapy administered in Lapinlahti Hospital, Helsinki in the 1950s ICD - 9 - CM 94.24 MeSH D003295 ( edit on Wikidata ) Insulin shock therapy or insulin coma therapy ( ICT ) was a form of psychiatric treatment in which patients were repeatedly injected with large doses of insulin in order to produce daily comas over several weeks. It was introduced in 1927 by Austrian - American psychiatrist Manfred Sakel and used extensively in the 1940s and 1950s, mainly for schizophrenia, before falling out of favour and being replaced by neuroleptic drugs in the 1960s. It was one of a number of physical treatments introduced into psychiatry in the first four decades of the 20th century. These included the convulsive therapies ( cardiazol / metrazol therapy and electroconvulsive therapy ), deep sleep therapy and psychosurgery. Insulin coma therapy and the convulsive therapies are collectively known as the shock therapies. Contents 1 Origins 2 Technique 3 Effects 4 Decline 5 Recent writing 6 Representation in media 7 See also 8 References 9 External links Origins In 1927 Sakel, who had recently qualified as a doctor in Vienna and was working in a psychiatric clinic in Berlin, began to use low ( sub-coma ) doses of insulin to treat drug addicts and psychopaths and after one of the patients experienced improved mental clarity after having slipped into an accidental coma, Sakel reasoned the treatment might work for mentally ill patients. Having returned to Vienna, he treated schizophrenic patients with larger doses of insulin in order to deliberately produce coma and sometimes convulsions. Sakel made public his results in 1933 and his methods were soon taken up by other psychiatrists. Joseph Wortis, after seeing Sakel practice it in 1935, introduced it to the US. British psychiatrists from the Board of Control visited Vienna in 1935 and 1936, and by 1938 31 hospitals in England and Wales had insulin treatment units. In 1936 Sakel moved to New York and promoted the use of insulin coma treatment in US psychiatric hospitals. By the late 1940s the majority of psychiatric hospitals in the US were using insulin coma treatment. Technique An insulin treatment ward, circa 1951, Roundway Hospital, Devizes, England Insulin coma therapy was a labour - intensive treatment that required trained staff and a special unit. Patients, who were almost invariably diagnosed with schizophrenia, were selected on the basis of having a good prognosis and the physical strength to withstand an arduous treatment. There were no standard guidelines for treatment. Different hospitals and psychiatrists developed their own protocols. Typically, injections were administered six days a week for about two months. The daily insulin dose was gradually increased to 100 -- 150 units until comas were produced, at which point the dose would be levelled out. Occasionally doses of up to 450 units were used. After about 50 or 60 comas, or earlier if the psychiatrist thought that maximum benefit had been achieved, the dose of insulin was rapidly reduced before treatment was stopped. Courses of up to 2 years have been documented. After the insulin injection patients would experience various symptoms of decreased blood glucose : flushing, pallor, perspiration, salivation, drowsiness or restlessness. Sopor and coma -- if the dose was high enough -- would follow. Each coma would last for up to an hour and be terminated by intravenous glucose or via naso - gastric tube. Seizures sometimes occurred before or during the coma. Many would be tossing, rolling, moaning, twitching, spasming or thrashing around. Some psychiatrists regarded seizures as therapeutic and patients were sometimes also given electroconvulsive therapy or cardiazol / metrazol convulsive therapy during the coma, or on the day of the week when they did n't have insulin treatment. When they were not in a coma, insulin coma patients were kept together in a group and given special treatment and attention. One handbook for psychiatric nurses, written by British psychiatrist Eric Cunningham Dax, instructs nurses to take their insulin patients out walking and occupy them with games and competitions, flower - picking and map - reading, etc. Patients required continuous supervision as there was a danger of hypoglycemic aftershocks after the coma. In `` modified insulin therapy '', used in the treatment of neurosis, patients were given lower ( sub-coma ) doses of insulin. Effects A few psychiatrists ( including Sakel ) claimed success rates for insulin coma therapy of over 80 % in the treatment of schizophrenia. A few others argued that it merely accelerated remission in those patients who would undergo remission anyway. The consensus at the time was somewhere in between, claiming a success rate of about 50 % in patients who had been ill for less than a year ( about double the spontaneous remission rate ) with no influence on relapse. Sakel suggested the therapy worked by `` causing an intensification of the tonus of the parasympathetic end of the autonomic nervous system, by blockading the nerve cell, and by strengthening the anabolic force which induces the restoration of the normal function of the nerve cell and the recovery of the patient. '' The shock therapies in general had developed on the erroneous premise that epilepsy and schizophrenia rarely occurred in the same patient. Another theory was that patients were somehow `` jolted '' out of their mental illness. The hypoglycemia ( pathologically low glucose levels ) that resulted from ICT made patients extremely restless, sweaty, and liable to further convulsions and `` after - shocks ''. In addition, patients invariably emerged from the long course of treatment `` grossly obese ''. The most severe risks of insulin coma therapy were death and brain damage, resulting from irreversible or prolonged coma respectively. A study at the time claimed that many of the cases of brain damage were actually therapeutic improvement because they showed `` loss of tension and hostility ''. Mortality risk estimates varied from about one percent to 4.9 percent. Decline Insulin coma therapy was used in most hospitals in the US and the UK during the 1940s and 1950s. The numbers of patients were restricted by the requirement for intensive medical and nursing supervision and the length of time it took to complete a course of treatment. For example, at one typical large British psychiatric hospital, Severalls Hospital in Essex, insulin coma treatment was given to 39 patients in 1956. In the same year, 18 patients received modified insulin treatment, while 432 patients were given electroconvulsive treatment. In 1953, British psychiatrist Harold Bourne published a paper entitled `` The insulin myth '' in the Lancet, in which he argued that there was no sound basis for believing that insulin coma therapy counteracted the schizophrenic process in a specific way. If treatment worked, he said, it was because patients were chosen for their good prognosis and were given special treatment : `` insulin patients tend to be an elite group sharing common privileges and perils ''. Prior to publishing `` The insulin myth '' in The Lancet, Bourne had tried to submit the article to the Journal of Mental Science ; after a 12 - month delay, the Journal informed Bourne they had rejected the article, telling him to `` get more experience ''. In 1957, when insulin coma treatment use was declining, the Lancet published the results of a randomized, controlled trial where patients were either given insulin coma treatment or identical treatment but with unconsciousness produced by barbiturates. There was no difference in outcome between the groups and the authors concluded that, whatever the benefits of the coma regimen, insulin was not the specific therapeutic agent. In 1958, Bourne published a paper on increasing disillusionment in the psychiatric literature about insulin coma therapy for schizophrenia. He suggested there were several reasons why it had received almost universal uncritical acceptance by reviews and textbooks for several decades despite the occasional disquieting negative finding, including that by the 1930s when it all started schizophrenics were considered inherently unable to engage in psychotherapy, and ICT `` provided a personal approach to the schizophrenic, suitably disguised as a physical treatment so as to slip past the prejudices of the age. '' Although coma therapy had largely fallen out of use in the US by the 1970s, it was still being practiced and researched in some hospitals, and may have continued for longer in countries such as China and the Soviet Union. Recent writing Recent articles about insulin coma treatment have attempted to explain why it was given such uncritical acceptance. In the US, Deborah Doroshow wrote that insulin coma therapy secured its foothold in psychiatry not because of scientific evidence or knowledge of any mechanism of therapeutic action, but due to the impressions it made on the minds of the medical practitioners within the local world in which it was administered and the dramatic recoveries observed in some patients. Today, she writes, those who were involved are often ashamed, recalling it as unscientific and inhumane. Administering insulin coma therapy made psychiatry seem a more legitimate medical field. Harold Bourne, who questioned the treatment at the time, said : `` It meant that psychiatrists had something to do. It made them feel like real doctors instead of just institutional attendants ''. One retired psychiatrist who was interviewed by Doroshow `` described being won over because his patients were so sick and alternative treatments did not exist ''. Doroshow argues that `` psychiatrists used complications to exert their practical and intellectual expertise in a hospital setting '' and that collective risk - taking established `` especially tight bonds among unit staff members ''. She finds it ironic that psychiatrists `` who were willing to take large therapeutic risks were extremely careful in their handling of adverse effects ''. Psychiatrists interviewed by Doroshow recalled how insulin coma patients were provided with various routines and recreational and group - therapeutic activities, to a much greater extent than most psychiatric patients. Insulin coma specialists often chose patients whose problems were the most recent and who had the best prognosis ; in one case discussed by Doroshow a patient had already started to show improvement before insulin coma treatment, and after the treatment denied that it had helped, but the psychiatrists nevertheless argued that it had. In the UK, psychiatrist Kingsley Jones sees the support of the Board of Control as important in persuading psychiatrists to use insulin coma therapy. The treatment then acquired the privileged status of a standard procedure, protected by professional organizational interests. He also notes that it has been suggested that the Mental Treatment Act 1930 encouraged psychiatrists to experiment with physical treatments. British lawyer Phil Fennell notes that patients `` must have been terrified '' by the insulin shock procedures and the effects of the massive overdoses of insulin, and were often rendered more compliant and easier to manage after a course. Leonard Roy Frank, an American human rights activist and survivor of 50 forced insulin coma treatments combined with ECT has described the treatment as `` the most devastating, painful and humiliating experience of my life '', a `` flat - out atrocity '' glossed over by psychiatric euphemism, and a violation of basic human rights. In 2013, French physician - and - novelist Laurent Seksik wrote an historical novel about the tragic life of Eduard Einstein : Le cas Eduard Einstein. He related the encounter between Dr Sakel and Mileva Maric, Albert Einstein 's first wife ( and Eduard 's mother ), and the way Sakel 's therapy had been given to Eduard, who was afflicted with schizophrenia. Representation in media Like many new medical treatments for diseases previously considered incurable, depictions of insulin shock therapy in the media were initially favorable. In the 1940 film Dr. Kildare 's Strange Case, young Kildare uses the new `` insulin shock cure for schizophrenia '' to bring a man back from insanity to prove that the surgeon who removed a brain tumor from the patient was n't at fault for the patient 's condition. The film dramatically shows a five - hour treatment that ends with a patient eating jelly sandwiches and reconnecting with his wife. Other films of the era began to show a more sinister approach, beginning with the 1946 film Shock, in which actor Vincent Price plays a doctor who plots to murder a patient using an overdose of insulin in order to keep the fact that he was a murderer the secret. More recent films include Frances ( 1982 ) in which actress Frances Farmer undergoes insulin shock treatment, and A Beautiful Mind, which depicted genius John Nash undergoing insulin treatment. In an episode of the medical drama House_M. D., Dr. House puts himself in an insulin shock to try to make his hallucinations disappear. See also Deep sleep therapy Electroconvulsive therapy Manfred Sakel References ^ Jump up to : Neustatter WL ( 1948 ) Modern psychiatry in practice. London : 224. ^ Jump up to : Jones, K ( 2000 ). `` Insulin coma therapy in schizophrenia '' ( PDF ). Journal of the Royal Society of Medicine. 93 ( 3 ) : 147 -- 149. PMC 1297956. PMID 10741319. Archived from the original ( PDF ) on 2009 - 02 - 20. ^ Jump up to : MJ Sakel ( 1956 ) The classical Sakel shock treatment : a reappraisal. In F. Marti - Ibanez et al. ( eds. ) The great physiodynamic therapies in psychiatry : an historical reappraisal. New York : 13 - 75. Jump up ^ GL Jones ( 1948 ) Psychiatric shock therapy : current uses and practices. Williamsburg : p17. ^ Jump up to : Doroshow, DB ( 2007 ). `` Performing a cure for schizophrenia : insulin coma therapy on the wards ''. Journal of the History of Medicine and Allied Sciences. 62 ( 2 ) : 213 -- 43. doi : 10.1093 / jhmas / jrl044. PMID 17105748. Archived from the original on 7 February 2009. ^ Jump up to : Maclay, WS ( 1953 ). `` Death Due to Treatment ''. Proceedings of the Royal Society of Medicine. 46 ( 1 ) : 13 -- 20. PMC 1918466. PMID 13027286. ^ Jump up to : C Allen ( 1949 ) Modern discoveries in medical psychology. London : 219 - 220. ^ Jump up to : WW Sargant and E Slater ( 1954 ) An introduction to the physical methods of treatment in psychiatry, 3rd edition. Edinburgh. Jump up ^ EC Dax ( 1947 ) Modern mental treatment : a handbook for nurses. London : 13 - 14. Jump up ^ Mayer - Gross W ( 1950 ). `` Insulin coma therapy of schizophrenia : some critical remarks on Dr Sakel 's report ''. Journal of Mental Science. 96 : 132 -- 135. ^ Jump up to : Phil Fennell ( 1996 ) Treatment Without Consent : Law, Psychiatry and the Treatment of Mentally Disordered People Since 1845 Routledge, 1996 ISBN 0 - 415 - 07787 - 7 Jump up ^ Revitch Eugene ( 1954 - 01 - 01 ). `` Observations on organic brain damage and clinical improvement following protracted insulin coma ( 1955 ) ''. The Psychiatric Quarterly. 28 : 72 -- 92. doi : 10.1007 / BF01567038. Retrieved 2014 - 04 - 15. Jump up ^ Ebaugh, FG ( 1943 ). `` A review of the drastic shock therapies in the treatment of the psychoses ''. Annals of Internal Medicine. 18 ( 3 ) : 279 -- 296. doi : 10.7326 / 0003 - 4819 - 18 - 3 - 279. Jump up ^ D Gittens ( 1998 ) Narratives of Severalls Hospital, 1913 - 1977. Oxford : 197 - 199. Jump up ^ Bourne, H. ( 1953 ). `` The insulin myth. Lancet ''. Ii. 265 ( 6798 ) : 964 -- 8. PMID 13110026. ^ Jump up to : Pimm, Jonathan ( April 2014 ). `` Profile : Dr Bourne 's identity - credit where credit 's due ''. The Psychiatric Bulletin. 38 ( 2 ) : 83 -- 85. doi : 10.1192 / pb. bp. 113.046060. PMC 4115399. PMID 25237504. Jump up ^ Ackner, B ; Harris, A ; Oldham, AJ ( 1957 ). `` Insulin treatment of schizophrenia ; a controlled study ''. Lancet. 272 ( 6969 ) : 607 -- 11. doi : 10.1016 / s0140 - 6736 ( 57 ) 91070 - x. PMID 13407078. Jump up ^ Insulin Coma In Decline Harold Bourne, American Journal of Psychiatry, May 01, 1958 ; 114 : 1015 - 1017. Jump up ^ Insulin coma therapy : Decrease of plasma tryptophan in man Journal of Neural Transmission 1976, Volume 39, Issue 4, pp 309 - 313 Jump up ^ Kalinowsky, LB ( 1980 ). `` The discovery of somatic treatments in psychiatry ''. Comprehensive Psychiatry. 21 ( 6 ) : 428 -- 435. doi : 10.1016 / 0010 - 440X ( 80 ) 90044 - 9. PMID 7000433. Jump up ^ Frank, LR ( 2002 ). `` Psychiatry 's Unholy Trinity -- Fraud, Fear and Force : a personal account ''. The Freeman. 52 : 11. Archived from the original on 2 March 2012. Jump up ^ Seksik, Laurent ( 2013 ). Le cas Eduard Einstein ( french ed. ). Paris : Flammarion. pp. 128 -- 131. ISBN 978 - 2081248571. External links The History of Shock Therapy in Psychiatry Drug Treatment in Modern Psychiatry 1944 textbook extract on ' The Insulin Treatment of Schizophrenia ' Insulin Coma Therapy by the head of the insulin coma unit at the Hillside Hospital in New York from 1952 to 1958 Shock Treatment - The Killing of Susan Kelly A poem by insulin / electro shock survivor Dorothy Dundas Psychiatry Portal Subspecialties Addiction psychiatry Biological psychiatry Child and adolescent psychiatry Cognitive neuropsychiatry Cross-cultural psychiatry Developmental disability Descriptive psychiatry Eating disorders Emergency psychiatry Forensic psychiatry Geriatric psychiatry Immuno - psychiatry Liaison psychiatry Military psychiatry Narcology Neuropsychiatry Palliative medicine Pain medicine Psychotherapy Sleep medicine Organizations American Academy of Child and Adolescent Psychiatry American Board of Psychiatry and Neurology American Neuropsychiatric Association American Psychiatric Association Campaign Against Psychiatric Abuse Chinese Society of Psychiatry Democratic Psychiatry European Psychiatric Association Global Initiative on Psychiatry Hong Kong College of Psychiatrists Independent Psychiatric Association of Russia Indian Psychiatric Society National Institute of Mental Health Philadelphia Association Royal Australian and New Zealand College of Psychiatrists Royal College of Psychiatrists Working Commission to Investigate the Use of Psychiatry for Political Purposes World Psychiatric Association Taiwanese Society of Child and Adolescent Psychiatry Related topics Anti-psychiatry Behavioral medicine Clinical neuroscience Imaging genetics Neuroimaging Neurophysiology Philosophy of psychiatry Political abuse of psychiatry Psychiatrist Psychiatric epidemiology Psychiatric genetics Psychiatric survivors movement Psychosomatic medicine Psycho - oncology Psychopharmacology Psychosurgery Psychoanalysis Lists Outline of the psychiatric survivors movement Psychiatrists Neurological disorders Counseling topics Psychotherapies Psychiatric medications by condition treated Retrieved from `` https://en.wikipedia.org/w/index.php?title=Insulin_shock_therapy&oldid=865398191 '' Categories : Psychiatric treatments Insulin therapies Schizophrenia Human subject research in psychiatry History of psychiatry Experimental medical treatments Coma Talk Contents About Wikipedia Asturianu Deutsch Español Français Latviešu 日本 語 Polski Русский Suomi 3 more Edit links This page was last edited on 23 October 2018, at 18 : 19 ( UTC ). 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Question: what was the treatment in a beautiful mind
Answer: insulin treatment