Fight - or - flight response - wikipedia Fight - or - flight response For other uses, see Fight or Flight. Fight or flight ? The fight - or - flight response ( also called hyperarousal, or the acute stress response ) is a physiological reaction that occurs in response to a perceived harmful event, attack, or threat to survival. It was first described by Walter Bradford Cannon. His theory states that animals react to threats with a general discharge of the sympathetic nervous system, preparing the animal for fighting or fleeing. More specifically, the adrenal medulla produces a hormonal cascade that results in the secretion of catecholamines, especially norepinephrine and epinephrine. The hormones estrogen, testosterone, and cortisol, as well as the neurotransmitters dopamine and serotonin, also affect how organisms react to stress. This response is recognised as the first stage of the general adaptation syndrome that regulates stress responses among vertebrates and other organisms. Contents 1 Physiology 1.1 Autonomic nervous system 1.1. 1 Sympathetic nervous system 1.1. 2 Parasympathetic nervous system 1.2 Reaction 1.3 Function of physiological changes 2 Emotional components 2.1 Emotion regulation 2.2 Emotional reactivity 3 Cognitive components 3.1 Content specificity 3.2 Perception of control 3.3 Social information processing 4 Other animals 4.1 Evolutionary perspective 4.2 Examples 4.3 Varieties of responses 5 See also 6 Notes 7 References 8 Further reading Physiology Autonomic nervous system See also : Autonomic nervous system The autonomic nervous system is a control system that acts largely unconsciously and regulates heart rate, digestion, respiratory rate, pupillary response, urination, and sexual arousal. This system is the primary mechanism in control of the fight - or - flight response and its role is mediated by two different components : the sympathetic nervous system and the parasympathetic nervous system. Sympathetic nervous system See also : Sympathetic nervous system The sympathetic nervous system originates in the spinal cord and its main function is to activate the physiological changes that occur during the fight - or - flight response. This component of the autonomic nervous system utilises and activates the release of norepinephrine in the reaction. Parasympathetic nervous system See also : Parasympathetic nervous system The parasympathetic nervous system originates in the sacral spinal cord and medulla, physically surrounding the sympathetic origin, and works in concert with the sympathetic nervous system. Its main function is to activate the `` rest and digest '' response and return the body to homeostasis after the fight or flight response. This system utilises and activates the release of the neurotransmitter acetylcholine. Reaction The fight - or - flight response The reaction begins in the amygdala, which triggers a neural response in the hypothalamus. The initial reaction is followed by activation of the pituitary gland and secretion of the hormone ACTH. The adrenal gland is activated almost simultaneously, via the sympathetic nervous system, and releases the hormone epinephrine. The release of chemical messengers results in the production of the hormone cortisol, which increases blood pressure, blood sugar, and suppresses the immune system. The initial response and subsequent reactions are triggered in an effort to create a boost of energy. This boost of energy is activated by epinephrine binding to liver cells and the subsequent production of glucose. Additionally, the circulation of cortisol functions to turn fatty acids into available energy, which prepares muscles throughout the body for response. Catecholamine hormones, such as adrenaline ( epinephrine ) or noradrenaline ( norepinephrine ), facilitate immediate physical reactions associated with a preparation for violent muscular action and : Acceleration of heart and lung action Paling or flushing, or alternating between both Inhibition of stomach and upper - intestinal action to the point where digestion slows down or stops General effect on the sphincters of the body Constriction of blood vessels in many parts of the body Liberation of metabolic energy sources ( particularly fat and glycogen ) for muscular action Dilation of blood vessels for muscles Inhibition of the lacrimal gland ( responsible for tear production ) and salivation Dilation of pupil ( mydriasis ) Relaxation of bladder Inhibition of erection Auditory exclusion ( loss of hearing ) Tunnel vision ( loss of peripheral vision ) Disinhibition of spinal reflexes Shaking. Function of physiological changes The physiological changes that occur during the fight or flight response are activated in order to give the body increased strength and speed in anticipation of fighting or running. Some of the specific physiological changes and their functions include : Increased blood flow to the muscles activated by diverting blood flow from other parts of the body. Increased blood pressure, heart rate, blood sugars, and fats in order to supply the body with extra energy. The blood clotting function of the body speeds up in order to prevent excessive blood loss in the event of an injury sustained during the response. Increased muscle tension in order to provide the body with extra speed and strength. Emotional components Emotion regulation See also : Emotional self - regulation In the context of the fight or flight response, emotional regulation is used proactively to avoid threats of stress or to control the level of emotional arousal. Emotional reactivity During the reaction, the intensity of emotion that is brought on by the stimulus will also determine the nature and intensity of the behavioral response. Individuals with higher levels of emotional reactivity may be prone to anxiety and aggression, which illustrates the implications of appropriate emotional reaction in the fight or flight response. Cognitive components Content specificity The specific components of cognitions in the fight or flight response seem to be largely negative. These negative cognitions may be characterised by : attention to negative stimuli, the perception of ambiguous situations as negative, and the recurrence of recalling negative words. There also may be specific negative thoughts associated with emotions commonly seen in the reaction. Perception of control See also : Control ( psychology ) Perceived control relates to an individual 's thoughts about control over situations and events. Perceived control should be differentiated from actual control because an individual 's beliefs about their abilities may not reflect their actual abilities. Therefore, overestimation or underestimation of perceived control can lead to anxiety and aggression. Social information processing See also : Social information processing ( cognition ) The social information processing model proposes a variety of factors that determine behavior in the context of social situations and preexisting thoughts. The attribution of hostility, especially in ambiguous situations, seems to be one of the most important cognitive factors associated with the fight or flight response because of its implications towards aggression. Other animals Evolutionary perspective An evolutionary psychology explanation is that early animals had to react to threatening stimuli quickly and did not have time to psychologically and physically prepare themselves. The fight or flight response provided them with the mechanisms to rapidly respond to threats against survival. Examples A typical example of the stress response is a grazing zebra. If the zebra sees a lion closing in for the kill, the stress response is activated as a means to escape its predator. The escape requires intense muscular effort, supported by all of the body 's systems. The sympathetic nervous system 's activation provides for these needs. A similar example involving fight is of a cat about to be attacked by a dog. The cat shows accelerated heartbeat, piloerection ( hair standing on end, normally to dissipate heat ), and pupil dilation, all signs of sympathetic arousal. Note that the zebra and cat still maintain homeostasis in all states. Varieties of responses This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. ( October 2016 ) Bison hunted by dogs Animals respond to threats in many complex ways. Rats, for instance, try to escape when threatened, but will fight when cornered. Some animals stand perfectly still so that predators will not see them. Many animals freeze or play dead when touched in the hope that the predator will lose interest. Other animals have alternative self - protection methods. Some species of cold - blooded animals change color swiftly, to camouflage themselves. These responses are triggered by the sympathetic nervous system, but, in order to fit the model of fight or flight, the idea of flight must be broadened to include escaping capture either in a physical or sensory way. Thus, flight can be disappearing to another location or just disappearing in place. And often both fight and flight are combined in a given situation. The fight or flight actions also have polarity -- the individual can either fight or flee against something that is threatening, such as a hungry lion, or fight for or fly towards something that is needed, such as the safety of the shore from a raging river. A threat from another animal does not always result in immediate fight or flight. There may be a period of heightened awareness, during which each animal interprets behavioral signals from the other. Signs such as paling, piloerection, immobility, sounds, and body language communicate the status and intentions of each animal. There may be a sort of negotiation, after which fight or flight may ensue, but which might also result in playing, mating, or nothing at all. An example of this is kittens playing : each kitten shows the signs of sympathetic arousal, but they never inflict real damage. See also Hypothalamic -- pituitary -- adrenal axis Coping ( psychology ) Defense physiology Emotional dysregulation Freezing behavior Escape distance The Relaxation Response Rest and digest Vasoconstriction Workplace bullying Yerkes -- Dodson law Acute stress reaction Anxiety Anxiety disorder Panic attack Phobia Social anxiety Social anxiety disorder Tend and befriend Body reactivity Notes Jump up ^ Cannon referred to `` the necessities of fighting or flight. '' in the first edition of ' Bodily Changes in Pain, Hunger, Fear and Rage ( 1915 ), p. 211. Some references say he first described the response in 1914 in The American Journal of Physiology. References Jump up ^ Cannon, Walter ( 1932 ). Wisdom of the Body. United States : W.W. Norton & Company. ISBN 0393002055. Jump up ^ Walter Bradford Cannon ( 1915 ). Bodily changes in pain, hunger, fear, and rage. New York : Appleton - Century - Crofts. p. 211. Jump up ^ Jansen, A ; Nguyen, X ; Karpitsky, V ; Mettenleiter, M ( 27 October 1995 ). `` Central Command Neurons of the Sympathetic Nervous System : Basis of the Fight - or - Flight Response ''. Science Magazine. 5236 ( 270 ). Jump up ^ Walter Bradford Cannon ( 1915 ). Bodily Changes in Pain, Hunger, Fear and Rage : An Account of Recent Researches into the Function of Emotional Excitement. Appleton - Century - Crofts. Jump up ^ `` Adrenaline, Cortisol, Norepinephrine : The Three Major Stress Hormones, Explained ''. Hufflington Post. April 19, 2014. Retrieved 16 August 2014. Jump up ^ Gozhenko, A ; Gurkalova, I.P. ; Zukow, W ; Kwasnik, Z ( 2009 ). PATHOLOGY -- Theory. Medical Student 's Library. Radom. pp. 270 -- 275. Jump up ^ Schmidt, A ; Thews, G ( 1989 ). `` Autonomic Nervous System ''. In Janig, W. Human Physiology ( 2 ed. ). New York, NY : Springer - Verlag. pp. 333 -- 370. CS1 maint : Multiple names : authors list ( link ) ^ Jump up to : Chudler, Eric. `` Neuroscience For Kids ''. University of Washington. Retrieved 19 April 2013. Jump up ^ Margioris, Andrew ; Tsatsanis, Christos ( April 2011 ). `` ACTH Action on the Adrenal ''. Endotext.org. Archived from the original on 6 March 2013. Retrieved 18 April 2013. Jump up ^ Padgett, David ; Glaser, R ( August 2003 ). `` How stress influences the immune response ''. Trends in Immunology. 24 ( 8 ) : 444 -- 448. doi : 10.1016 / S1471 - 4906 ( 03 ) 00173 - X. PMID 12909458. Jump up ^ King, Michael. `` PATHWAYS : GLYCOGEN & GLUCOSE ''. Washington University, St. Louis. Jump up ^ `` HOW CELLS COMMUNICATE DURING THE FIGHT OR FLIGHT RESPONSE ''. University of Utah. Archived from the original on 8 August 2013. Retrieved 18 April 2013. ^ Jump up to : Henry Gleitman, Alan J. Fridlund and Daniel Reisberg ( 2004 ). Psychology ( 6 ed. ). W.W. Norton & Company. ISBN 0 - 393 - 97767 - 6. Jump up ^ Stress Management for Health Course. `` The Fight Flight Response ''. Retrieved 19 April 2013. Jump up ^ Olpin, Michael. `` The Science of Stress ''. Weber State University. Jump up ^ Cistler, Josh ; Bunmi O. Olatunji ; Matthew T. Feldner ; John P. Forsyth ( 2010 ). `` Emotion Regulation and the Anxiety Disorders : An Integrative Review ''. Journal of Psychopathology and Behavioral Assessment. 32 ( 1 ) : 68 -- 82. doi : 10.1007 / s10862 - 009 - 9161 - 1. PMC 2901125. PMID 20622981. Jump up ^ Gross, James ( 1998 ). `` Sharpening the Focus : Emotion Regulation, Arousal, and Social Competence ''. Psychological Inquiry. 9 ( 4 ) : 287 -- 290. doi : 10.1207 / s15327965pli0904_8. Jump up ^ Avero, Pedro ; Calvo, M ( 1 July 1999 ). `` Emotional reactivity to social - evaluative stress : genderdifferences in response systems concordance ''. Personality and Individual Differences. 27 ( 1 ) : 155 -- 170. doi : 10.1016 / S0191 - 8869 ( 98 ) 00229 - 3. Jump up ^ Carthy, T ; Horesh N ; Apter A ; Edge MD ; Gross JJ ( May 2010 ). `` Emotional reactivity and cognitive regulation in anxious children ''. Behavior Research and Therapy. 48 ( 5 ) : 384 -- 393. doi : 10.1016 / j. brat. 2009.12. 013. Jump up ^ Valiente, C ; Eisenberg N ; Smith CL ; Reiser M ; Fabes RA ; Losoya S ; Guthrie IK ; Murphy BC ( December 2003 ). `` The relations of effortful control and reactive control to children 's externalising problems : A longitudinal assessment ''. Personality. 71 ( 6 ) : 1171 -- 1196. doi : 10.1111 / 1467 - 6494.7106011. PMID 14633062. Jump up ^ Reid, Sophie C. ; Salmon, Karen ; Peter F. Lovibond ( October 2006 ). `` Cognitive Biases in Childhood Anxiety, Depression, and Aggression : Are They Pervasive or Specific ? ''. Cognitive Therapy and Research. 30 ( 5 ) : 531 -- 549. doi : 10.1007 / s10608 - 006 - 9077 - y. Jump up ^ Beck, Aaron ( 1979 ). Cognitive Therapy and the Emotional Disorders. United States : Penguin Books. Jump up ^ Weems, CF ; Silverman, WK ( April 2006 ). `` An integrative model of control : implications for understanding emotion regulation and dysregulation in childhood anxiety ''. Journal of Affective disorders. 91 ( 2 ) : 113 -- 124. doi : 10.1016 / j. jad. 2006.01. 009. Jump up ^ Brendgen, M ; Vitaro F ; Turgeon L ; Poulin F ; Wanner B ( June 2004 ). `` Is there a dark side of positive illusions ? Overestimation of social competence and subsequent adjustment in aggressive and nonaggressive children ''. Journal of Abnormal Child Psychology. 32 ( 3 ) : 305 -- 320. doi : 10.1023 / B : JACP.0000026144.08470.cd. PMID 15228179. Jump up ^ Crick, Nicki ; Dodge, Kenneth ( January 1994 ). `` A review and reformulation of social information - processing mechanisms in children 's social adjustment ''. Psychological Bulletin. 115 ( 1 ) : 74 -- 101. doi : 10.1037 / 0033 - 2909.115. 1.74. Jump up ^ Dodge, Kenneth ( March 1980 ). `` Social cognition and children 's aggressive behavior ''. Journal of Child Development. 51 ( 1 ) : 162 -- 170. doi : 10.2307 / 1129603. Jump up ^ Grohol, John. `` What 's the purpose of the fight or flight response ? ''. Retrieved 18 April 2013. Jump up ^ Goldstein, David ; Kopin, I ( 2007 ). `` Evolution of concepts of stress ''. Stress. 10 ( 2 ) : 109 -- 20. doi : 10.1080 / 10253890701288935. PMID 17514579. Jump up ^ Gill, A.C. ( 2004 ). Revision of the Indo - Pacific dottyback fish subfamily Pseudochrominae ( Perciformes : Pseudochromidae ). Smithiana Monographs. pp. 1 -- 123. Further reading Sapolsky, Robert M., 1994. Why Zebras Do n't Get Ulcers. W.H. Freeman and Company. This article incorporates public domain material from the United States Government document `` http://www.surgeongeneral.gov/library/mentalhealth/chapter4/sec2_1.html ''. Retrieved from `` https://en.wikipedia.org/w/index.php?title=Fight-or-flight_response&oldid=851137076 '' Categories : Sympathetic nervous system Aggression Fear Dichotomies Psychological theories Hidden categories : CS1 maint : Multiple names : authors list Articles needing additional references from October 2016 All articles needing additional references Wikipedia articles incorporating text from public domain works of the United States Government Talk Contents About Wikipedia Deutsch Español Esperanto فارسی Français हिन्दी Italiano עברית Magyar Bahasa Melayu Nederlands 日本 語 Português Русский Scots Simple English Svenska ไทย Tiếng Việt 中文 12 more Edit links This page was last edited on 20 July 2018, at 09 : 51 ( UTC ). Text is available under the Creative Commons Attribution - ShareAlike License ; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. 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Question: where is the fight or flight response located in the brain
Answer: the adrenal medulla