Mycobacterium avium - intracellulare infection - wikipedia Mycobacterium avium - intracellulare infection Mycobacterium avium - intracellulare infection Synonym Mycobacterium avium complex infection CT scan of patient with right middle lobe aspiration and Mycobacterium avium infection consistent with Lady Windermere syndrome Classification and external resources Specialty infectious disease ICD - 10 A31. 0 ICD - 9 - CM 031.0 DiseasesDB 29182 eMedicine med / 1532 MeSH D015270 ( edit on Wikidata ) Mycobacterium avium - intracellulare infection ( MAI ) is an atypical mycobacterial infection, i.e. one with nontuberculous mycobacteria or NTM, caused by Mycobacterium avium complex ( `` MAC '' ), which is made of three mycobacteria species, M. avium, M. intracellulare, and M. chimaera. This infection causes respiratory illness in birds, pigs, and humans, especially in immunocompromised people. In the later stages of AIDS it can be very severe. It usually first presents as a persistent cough. It is typically treated with a series of three antibiotics for a period of at least six months. M. avium, M. intracellulare, and M. chimaera are each saprotrophic organisms present in soil and water ; entry into hosts is usually via the gastrointestinal tract, but also can be via the lungs. MAC infections can cause fevers, diarrhea, malabsorption, as well as loss of appetite and weight loss, and can disseminate to the bone marrow. MAI is typically resistant to standard mycobacterial therapies. Contents 1 Signs and symptoms 1.1 Children 2 Cause 2.1 Bacteria 2.2 Risk factors 3 Pathophysiology 4 Diagnosis 4.1 HIV infection 5 Prevention 6 Treatment 6.1 HIV - infected children 7 Society and culture 7.1 Terminology 7.2 Literary reference 8 See also 9 References 10 External links Signs and symptoms Symptoms are similar to tuberculosis ( TB ), and include fever, fatigue, and weight loss. Pulmonary involvement is similar to TB, while diarrhea and abdominal pain are associated with gastrointestinal involvement. Children M. avium and M. haemophilum infections in children form a distinct clinical entity, not associated with abnormalities of the immune system. M. avium typically causes unilateral swelling of one of the lymph nodes of the neck. This node is firm at the beginning, but a collarstud abscess ' is formed eventually, which is a characteristic blue - purple in colour with multiple discharging sinuses. The treatment of choice is surgical excision of the affected lymph nodes, with antibiotic treatment ( usually clarithromycin and rifabutin for 18 to 24 months ) reserved for those patients who can not have surgery. Cause MAC bacteria are common in the environment and cause infection when inhaled or swallowed. Recently, M. avium has been found to deposit and grow in bathroom shower heads from which it may be easily aerosolized and inhaled. Bacteria Mycobacterium avium complex ( MAC ), also called Mycobacterium avium - intracellulare complex, is a microbial complex of three Mycobacterium species ( i.e. M. avium, M. intracellulare, and M. chimaera. It causes Mycobacterium avium - intracellulare infection. Some sources also include Mycobacterium avium subspecies paratuberculosis ( MAP ). Risk factors MAI is common in immunocompromised individuals, including senior citizens and those with HIV / AIDS or cystic fibrosis. Bronchiectasis, the bronchial condition which causes unnatural enlargement of the bronchial tubes, is commonly found with MAI infection. Whether the bronchiectasis leads to the MAC infection or is the result of it is not always known. The Mycobacterium avium complex ( MAC ) includes common atypical bacteria, i.e. nontuberculous mycobacteria ( NTM ), found in the environment which can infect people with HIV and low CD4 cell count ( below 100 / microliter ) ; mode of infection is usually inhalation or ingestion. MAC causes disseminated disease in up to 40 % of people with human immunodeficiency virus ( HIV ) in the United States, producing fever, sweats, weight loss, and anemia. Disseminated MAC characteristically affects people with advanced HIV disease and peripheral CD4+ T - lymphocyte counts less than 100 cells / uL. Effective prevention and therapy of MAC has the potential to contribute substantially to improved quality of life and duration of survival for HIV - infected persons. Pathophysiology Mycobacterium avium complex is the most commonly found form of non-tuberculous mycobacteria. Immunodeficiency is not a requirement for MAI. Mycobacterium avium complex ( MAC ) usually affects patients with abnormal lungs or bronchi. However, Candace Baker, Jerome Reich and Richard Johnson describe a series of six patients with MAC infection of the right middle lobe or left lingula who did not have any predisposing lung disorders. The right middle lobe and left lingula of the lungs are served by bronchi that are oriented downward when a person is in the upright position. As a result, these areas of the lung may be more dependent upon vigorous voluntary expectoration ( cough ) for clearance of bacteria and secretions. Since the six patients in their retrospective case series were older females, Reich and Johnson and Baker proposed that patients without a vigorous cough may develop right middle lobe or left lingular infection with MAC. They proposed this syndrome be named Lady Windermere syndrome, after the character Lady Windermere in Oscar Wilde 's play Lady Windermere 's Fan. However, little research has confirmed this speculative cause. Diagnosis Diagnosis can be achieved through blood cultures, or cultures of other bodily fluids such as sputum. Bone marrow culture can often yield an earlier diagnosis, but is usually avoided as an initial diagnostic step because of its invasiveness. Many people will have anemia and neutropenia if bone marrow is involved. MAC bacteria should always be considered in a person with HIV infection presenting with diarrhea. The diagnosis requires consistent symptoms with two additional signs : Chest X-ray or CT scan showing evidence of right middle lobe ( or left lingular lobe ) lung infection Sputum culture or bronchoalveolar lavage culture demonstrating the infection is caused by MAC Disseminated MAC is most readily diagnosed by one positive blood culture. Blood cultures should be performed in patients with symptoms, signs, or laboratory abnormalities compatible with mycobacterium infection. Blood cultures are not routinely recommended for asymptomatic persons, even for those who have CD4+ T - lymphocyte counts less than 100 cells / uL. HIV infection MAC in patients with HIV disease is theorized to represent recent acquisition rather than latent infection reactivating ( which is the case in many other opportunistic infections in immunocompromised patients ). The risk of MAC is inversely related to the patient 's CD4 count, and increases significantly when the CD4 count decreases below 50 cells / mm3. Other risk factors for acquisition of MAC infection include using an indoor swimming pool, consumption of raw or partially cooked fish or shellfish, bronchoscopy and treatment with granulocyte stimulating factor. Disseminated disease was previously the common presentation prior to the advent of highly active antiretroviral therapy ( HAART ). Today, in regions where HAART is the standard of care, localized disease presentation is more likely. This generally includes a focal lymphadenopathy / lymphadenitis. Prevention People with AIDS are given macrolide antibiotics such as azithromycin for prophylactic treatment. People with HIV infection and less than 50 CD4+ T - lymphocytes / uL should be administered prophylaxis against MAC. Prophylaxis should be continued for the patient 's lifetime unless multiple drug therapy for MAC becomes necessary because of the development of MAC disease. Clinicians must weigh the potential benefits of MAC prophylaxis against the potential for toxicities and drug interactions, the cost, the potential to produce resistance in a community with a high rate of tuberculosis, and the possibility that the addition of another drug to the medical regimen may adversely affect patients ' compliance with treatment. Because of these concerns, therefore, in some situations rifabutin prophylaxis should not be administered. Before prophylaxis is administered, patients should be assessed to ensure that they do not have active disease due to MAC, M. tuberculosis, or any other mycobacterial species. This assessment may include a chest radiograph and tuberculin skin test. Rifabutin, by mouth daily, is recommended for the people 's lifetime unless disseminated MAC develops, which would then require multiple drug therapy. Although other drugs, such as azithromycin and clarithromycin, have laboratory and clinical activity against MAC, none has been shown in a prospective, controlled trial to be effective and safe for prophylaxis. Thus, in the absence of data, no other regimen can be recommended at this time. The 300 - mg dose of rifabutin has been well tolerated. Adverse effects included neutropenia, thrombocytopenia, rash, and gastrointestinal disturbances. Treatment Postinfection treatment involves a combination of antituberculosis antibiotics, including rifampicin, rifabutin, ciprofloxacin, amikacin, ethambutol, streptomycin, clarithromycin or azithromycin. NTM infections are usually treated with a three - drug regimen of either clarithromycin or azithromycin, plus rifampicin and ethambutol. Treatment typically lasts at least 12 months. Although studies have not yet identified an optimal regimen or confirmed that any therapeutic regimen produces sustained clinical benefit for patients with disseminated MAC, the Task Force concluded that the available information indicated the need for treatment of disseminated MAC. The Public Health Service therefore recommends that regimens be based on the following principles : Treatment regimens outside a clinical trial should include at least two agents. Every regimen should contain either azithromycin or clarithromycin ; many experts prefer ethambutol as a second drug. Many clinicians have added one or more of the following as second, third, or fourth agents : clofazimine, rifabutin, rifampin, ciprofloxacin, and in some situations amikacin. Isoniazid and pyrazinamide are not effective for the therapy of MAC. Therapy should continue for the lifetime of the patient if clinical and microbiologic improvement is observed. Clinical manifestations of disseminated MAC -- such as fever, weight loss, and night sweats -- should be monitored several times during the initial weeks of therapy. Microbiologic response, as assessed by blood culture every 4 weeks during initial therapy, can also be helpful in interpreting the efficacy of a therapeutic regimen. Most patients who ultimately respond show substantial clinical improvement in the first 4 -- 6 weeks of therapy. Elimination of the organisms from blood cultures may take somewhat longer, often requiring 4 -- 12 weeks. HIV - infected children HIV - infected children less than 12 years of age also develop disseminated MAC. Some age adjustment is necessary when clinicians interpret CD4+ T - lymphocyte counts in children less than 2 years of age. Diagnosis, therapy, and prophylaxis should follow recommendations similar to those for adolescents and adults. Society and culture Terminology `` Lady Windermere syndrome '' is one term to describe infection in the lungs due to MAC. It is named after a character in Oscar Wilde 's play Lady Windermere 's Fan. In recent years, some have described the eponym as inappropriate, and some have noted that it would have been unlikely that Lady Windermere had the condition to which her name was assigned. The more commonly used term is nontuberculous mycobacteria ( NTM ) infection, or non-tuberculous mycobacterial infection ( NMI ). There is no evidence that a person 's reluctance to spit has any causal role in NTM infection, the chief reason for the term having been applied to older women presenting with the condition. Lady Windermere syndrome is a type of mycobacterial lung infection. Literary reference The original Chest article proposing the existence and pathophysiology of the Lady Windermere syndrome suggested the character Lady Windermere in Oscar Wilde 's Victorian - era play Lady Windermere 's Fan is a good example of the fastidious behavior believed to cause the syndrome. The article states : We offer the term, Lady Windermere 's Syndrome, from the Victorian - era play, Lady Windermere 's Fan, to convey the fastidious behavior hypothesized : `` How do you do, Lord Darlington. No, I ca n't shake hands with you. My hands are all wet with the roses. '' Victorian women presumably believed `` ladies do n't spit, '' and consequently might have been predisposed to develop lung infection. Shortly after the Lady Windermere syndrome was proposed, a librarian wrote a letter to the editor of Chest challenging the use of Lady Windermere as the eponymous ancestor of the proposed syndrome. In the play, Lady Windermere is a vivacious young woman, married only two years, who never coughs or displays any other signs of illness. While her avoidance of shaking hands might be interpreted as `` fastidiousness '', two alternative explanations may be just as probable : 1 ) Lady Windermere actually is in the midst of arranging flowers and consequently can not properly greet her guest : ( LADY WINDERMERE is at table R., arranging roses in a blue bowl. ) 2 ) Lady Windermere wishes to discourage the flirtatious advances of her would - be suitor Lord Darlington and cites her wet hands as an excuse to keep him from touching her : LADY WINDERMERE. Lord Darlington, you annoyed me last night at the Foreign Office. I am afraid you are going to annoy me again... LORD DARLINGTON. ( Takes chair and goes across L.C. ) I am quite miserable, Lady Windermere. You must tell me what I did. ( Sits down at table L. ) LADY WINDERMERE. Well, you kept paying me elaborate compliments the whole evening. ) The scholars highlight the literary malapropism, but some in the medical community have adopted the term regardless, and peer - reviewed medical journals still sometimes mention the Lady Windermere syndrome, although it is increasingly viewed as a limiting and sexist term for a serious bacterial infection. See also Paratuberculosis References Jump up ^ Medscape Reference - Mycobacterium Avium - Intracellulare Author : Janak Koirala, MD, MPH, FACP, FIDSA ; Chief Editor : Burke A Cunha, MD, Updated : Jan 12, 2011 Jump up ^ Lindeboom JA, Kuijper EJ, van Coppenraet ES, Lindeboom R, Prins JM ( 2007 ). `` Surgical excision versus antibiotic treatment for nontuberculous mycobacterial cervicofacial lymphadenitis in children : A multicenter, randomized, controlled trial ''. Clin Infect Dis. 44 ( 8 ) : 1057 -- 64. doi : 10.1086 / 512675. PMID 17366449. Jump up ^ Showerheads may harbor bacteria dangerous to some By RANDOLPH E. SCHMID, AP Science Writer Randolph E. Schmid, Ap Science Writer -- Mon Sep 14, 9 : 19 pm ET Jump up ^ Elsevier, Dorland 's Illustrated Medical Dictionary, Elsevier. Jump up ^ White, Lois ( 2004 ). Foundations of Nursing. Cengage Learning. p. 1298. ISBN 978 - 1 - 4018 - 2692 - 5. Jump up ^ `` Disease Listing, Mycobacterium avium Complex ''. CDC Bacterial, Mycotic Diseases. Retrieved 2010 - 11 - 04. Jump up ^ Irving, Peter ; Rampton, David ; Shanahan, Fergus ( 2006 ). Clinical dilemmas in inflammatory bowel disease. Wiley - Blackwell. p. 36. ISBN 978 - 1 - 4051 - 3377 - 7. Jump up ^ `` Bronchiectasis with Mycobacterium avium Complex Infection ''. New England Journal of Medicine. 346 : 1372. doi : 10.1056 / NEJMicm010899. Jump up ^ Horsburgh CR ( May 1991 ). `` Mycobacterium avium complex infection in the acquired immunodeficiency syndrome ''. N. Engl. J. Med. 324 ( 19 ) : 1332 -- 8. doi : 10.1056 / NEJM199105093241906. PMID 2017230. Jump up ^ Chaisson RE, Moore RD, Richman DD, Keruly J, Creagh T ( August 1992 ). `` Incidence and natural history of Mycobacterium avium - complex infections in patients with advanced human immunodeficiency virus disease treated with zidovudine. The Zidovudine Epidemiology Study Group ''. Am. Rev. Respir. Dis. 146 ( 2 ) : 285 -- 9. doi : 10.1164 / ajrccm / 146.2. 285. PMID 1362634. Jump up ^ Havlik JA, Horsburgh CR, Metchock B, Williams PP, Fann SA, Thompson SE ( March 1992 ). `` Disseminated Mycobacterium avium complex infection : clinical identification and epidemiologic trends ''. J. Infect. Dis. 165 ( 3 ) : 577 -- 80. doi : 10.1093 / infdis / 165.3. 577. PMID 1347060. ^ Jump up to : U.S. Public Health Service Task Force on Prophylaxis and Therapy for Mycobacterium avium Complex ( June 1993 ). `` Recommendations on prophylaxis and therapy for disseminated Mycobacterium avium complex for adults and adolescents infected with human immunodeficiency virus ''. MMWR Recomm Rep. 42 ( RR - 9 ) : 14 -- 20. PMID 8393134. Jump up ^ Wickremasinghe M, Ozerovitch LJ, Davies G, et al. ( December 2005 ). `` Non-tuberculous mycobacteria in patients with bronchiectasis ''. Thorax. 60 ( 12 ) : 1045 -- 51. doi : 10.1136 / thx. 2005.046631. PMC 1747265. PMID 16227333. Jump up ^ Martins AB, Matos ED, Lemos AC ( April 2005 ). `` Infection with the Mycobacterium avium complex in patients without predisposing conditions : a case report and literature review ''. Braz J Infect Dis. 9 ( 2 ) : 173 -- 9. doi : 10.1590 / s1413 - 86702005000200009. PMID 16127595. Jump up ^ http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/infectious-disease/nontuberculous-mycobacterial-disorders/Default.htm#epidemiology Jump up ^ Paul Volberding ; Merle A. Sande ( 2008 ). Global HIV / AIDS medicine. Elsevier Health Sciences. pp. 361 --. ISBN 978 - 1 - 4160 - 2882 - 6. Retrieved 5 November 2010. Jump up ^ Reich JM, Johnson RE ( June 1992 ). `` Mycobacterium avium complex pulmonary disease presenting as an isolated lingular or middle lobe pattern. The Lady Windermere syndrome ''. Chest. 101 ( 6 ) : 1605 -- 9. doi : 10.1378 / chest. 101.6. 1605. PMID 1600780. Jump up ^ Wilde, Oscar ( 1940 ). The Importance of Being Earnest and Other Plays. Penguin. ISBN 0 - 14 - 048209 - 1. Jump up ^ Kasthoori JJ, Liam CK, Wastie ML ( February 2008 ). `` Lady Windermere syndrome : an inappropriate eponym for an increasingly important condition '' ( PDF ). Singapore Med J. 49 ( 2 ) : e47 -- 9. PMID 18301826. Jump up ^ Rubin BK ( October 2006 ). `` Did Lady Windermere have cystic fibrosis ? ''. Chest. 130 ( 4 ) : 937 -- 8. doi : 10.1378 / chest. 130.4. 937. PMID 17035420. Jump up ^ http://www.nationaljewish.org/healthinfo/conditions/ntm/causes Jump up ^ Subcommittee Of The Joint Tuberculosis Committee Of The British Thoracic Society, ( March 2000 ). `` Management of opportunist mycobacterial infections : Joint Tuberculosis Committee Guidelines 1999. Subcommittee of the Joint Tuberculosis Committee of the British Thoracic Society ''. Thorax. 55 ( 3 ) : 210 -- 8. doi : 10.1136 / thorax. 55.3. 210. PMC 1745689. PMID 10679540. Jump up ^ `` Chest -- eLetters for Reich and Johnson, 101 ( 6 ) 1605 - 1609 ''. ^ Jump up to : `` Oscar Wilde : Lady Windermere 's Fan : ACT I. Morning - room in Lord Windermere 's house. - Free Online Library ''. Jump up ^ `` oscholars ''. Jump up ^ Sexton P, Harrison AC ( June 2008 ). `` Susceptibility to nontuberculous mycobacterial lung disease ''. Eur. Respir. J. 31 ( 6 ) : 1322 -- 33. doi : 10.1183 / 09031936.00140007. PMID 18515557. Jump up ^ Kasthoori JJ, Liam CK, Wastie ML ( February 2008 ). `` Lady Windermere syndrome : an inappropriate eponym for an increasingly important condition ''. Singapore Med J. 49 : e47 -- 9. PMID 18301826. External links Mycobacterium avium - intracellulare Infection at the US National Library of Medicine Medical Subject Headings ( MeSH ) hide Oscar Wilde 's Lady Windermere 's Fan Films Lady Windermere 's Fan ( 1916 ) Lady Windermere 's Fan ( 1925 ) El abanico de Lady Windermere ( 1944 ) The Fan ( 1949 ) A Good Woman ( 2004 ) Other After the Ball ( musical ) Lady Windermere syndrome Lady Windermere 's Fan ( mathematics ) hide Gram - positive bacterial infection : Actinobacteria ( primarily A00 -- A79, 001 -- 041, 080 -- 109 ) Actinomycineae Actinomycetaceae Actinomyces israelii Actinomycosis Cutaneous actinomycosis Tropheryma whipplei Whipple 's disease Arcanobacterium haemolyticum Arcanobacterium haemolyticum infection Actinomyces gerencseriae Propionibacteriaceae Propionibacterium acnes Corynebacterineae Mycobacteriaceae M. tuberculosis / M. bovis Tuberculosis : Ghon focus / Ghon 's complex Pott disease brain Meningitis Rich focus Tuberculous lymphadenitis Tuberculous cervical lymphadenitis cutaneous Scrofuloderma Erythema induratum Lupus vulgaris Prosector 's wart Tuberculosis cutis orificialis Tuberculous cellulitis Tuberculous gumma Lichen scrofulosorum Tuberculid Papulonecrotic tuberculid Primary inoculation tuberculosis Miliary Tuberculous pericarditis Urogenital tuberculosis Multi-drug - resistant tuberculosis Extensively drug - resistant tuberculosis M. leprae Leprosy : Tuberculoid leprosy Borderline tuberculoid leprosy Borderline leprosy Borderline lepromatous leprosy Lepromatous leprosy Histoid leprosy Nontuberculous R1 : M. kansasii M. marinum Aquarium granuloma R2 : M. gordonae R3 : M. avium complex / Mycobacterium avium / Mycobacterium intracellulare / MAP MAI infection M. ulcerans Buruli ulcer M. haemophilum R4 / RG : M. fortuitum M. chelonae M. abscessus Nocardiaceae Nocardia asteroides / Nocardia brasiliensis Nocardiosis Rhodococcus equi Corynebacteriaceae Corynebacterium diphtheriae Diphtheria Corynebacterium minutissimum Erythrasma Corynebacterium jeikeium Group JK corynebacterium sepsis Bifidobacteriaceae Gardnerella vaginalis Retrieved from `` https://en.wikipedia.org/w/index.php?title=Mycobacterium_avium-intracellulare_infection&oldid=833251289 '' Categories : Bacterial diseases Hidden categories : Infobox medical condition All articles with unsourced statements Articles with unsourced statements from June 2012 Talk Contents About Wikipedia Polski Português Edit links This page was last edited on 30 March 2018, at 13 : 47. 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Question: which microorganisms cause mycobacterium avium complex (mac) infection
Answer: M. avium