Chlorpromazine - wikipedia Chlorpromazine Not to be confused with Chlorpropamide. Chlorpromazine Clinical data Trade names Largactil, Thorazine, others AHFS / Drugs.com Monograph MedlinePlus a682040 License data US FDA : Chlorpromazine Pregnancy category AU : C US : C ( Risk not ruled out ) Routes of administration Oral ( tablets and syrup available ), rectal, IM, IV infusion ATC code N05AA01 ( WHO ) Legal status Legal status AU : S4 ( Prescription only ) CA : ℞ - only UK : POM ( Prescription only ) US : ℞ - only Pharmacokinetic data Bioavailability 10 -- 80 % ( Oral ; large interindividual variation ) Protein binding 90 -- 99 % Metabolism Liver, mostly CYP2D6 - mediated Biological half - life 30 hours Excretion Urine ( 43 -- 65 % in 24 hrs ) Identifiers IUPAC name 3 - ( 2 - chloro - 10H - phenothiazin - 10 - yl ) - N, N - dimethyl - propan - 1 - amine CAS Number 50 - 53 - 3 ( free base ) 69 - 09 - 0 ( hydrochloride ) PubChem CID 2726 IUPHAR / BPS 83 DrugBank DB00477 ChemSpider 2625 UNII U42B7VYA4P KEGG D00270 ChEBI CHEBI : 3647 ChEMBL CHEMBL71 ECHA InfoCard 100.000. 042 Chemical and physical data Formula C H Cl N S Molar mass 318.86 g / mol ( free base ) 355.33 g / mol ( hydrochloride ) 3D model ( JSmol ) Interactive image SMILES CN ( C ) CCCN1c2ccccc2Sc3c1cc ( cc3 ) Cl InChI InChI = 1S / C17H19ClN2S / c1 - 19 ( 2 ) 10 - 5 - 11 - 20 - 14 - 6 - 3 - 4 - 7 - 16 ( 14 ) 21 - 17 - 9 - 8 - 13 ( 18 ) 12 - 15 ( 17 ) 20 / h3 - 4, 6 - 9, 12H, 5, 10 - 11H2, 1 - 2H3 Key : ZPEIMTDSQAKGNT - UHFFFAOYSA - N ( verify ) Chlorpromazine ( CPZ ), marketed under the trade names Thorazine and Largactil among others, is an antipsychotic medication. It is primarily used to treat psychotic disorders such as schizophrenia. Other uses include the treatment of bipolar disorder, attention deficit hyperactivity disorder, nausea and vomiting, anxiety before surgery, and hiccups that do not improve following other measures. It can be given by mouth, by injection into a muscle, or into a vein. Common side effects include movement problems, sleepiness, dry mouth, low blood pressure upon standing, and increased weight. Serious side effects may include the potentially permanent movement disorder tardive dyskinesia, neuroleptic malignant syndrome, and low white blood cell levels. In older people with psychosis as a result of dementia it may increase the risk of death. It is unclear if it is safe for use in pregnancy. Chlorpromazine is in the typical antipsychotic class. Its mechanism of action is not entirely clear but believed to be related to its ability as a dopamine antagonist. It also has anti-serotonergic and antihistaminergic properties. Chlorpromazine was discovered in 1950 and was the first antipsychotic. It is on the World Health Organization 's List of Essential Medicines, the most effective and safe medicines needed in a health system. Its introduction has been labeled as one of the great advances in the history of psychiatry. It is available as a generic medication. The wholesale cost in the developing world is between US $0.02 and US $0.12 per day. In the United States it costs about US $2 per day. Contents 1 Medical uses 1.1 Other 2 Adverse effects 2.1 Contraindications 2.2 Interactions 2.3 Tolerance and withdrawal 3 Pharmacology 3.1 Pharmacokinetics 3.2 Pharmacodynamics 3.3 Peripheral effects 4 History 5 Brand names 6 Veterinary use 7 Research 7.1 Amebocidal ability 8 References 9 External links Medical uses Chlorpromazine is classified as a low - potency typical antipsychotic and in the past was used in the treatment of both acute and chronic psychoses, including schizophrenia and the manic phase of bipolar disorder, as well as amphetamine - induced psychoses. Low - potency antipsychotics have more anticholinergic side effects, such as dry mouth, sedation, and constipation, and lower rates of extrapyramidal side effects, while high - potency antipsychotics ( such as haloperidol ) have the reverse profile. In a 2013 comparison of 15 antipsychotics in schizophrenia, chlorpromazine demonstrated mild - standard effectiveness. It was 13 % more effective than lurasidone and iloperidone, approximately as effective as ziprasidone and asenapine, and 12 - 16 % less effective than haloperidol, quetiapine, and aripiprazole. Chlorpromazine has also been used in porphyria and as part of tetanus treatment. It still is recommended for short - term management of severe anxiety and psychotic aggression. Resistant and severe hiccups, severe nausea / emesis, and preanesthetic conditioning are other uses. Symptoms of delirium in medically - hospitalized AIDS patients have been effectively treated with low doses of chlorpromazine. Other Chlorpromazine is occasionally used off - label for treatment of severe migraine. It is often, particularly as palliation, used in small doses to reduce nausea suffered by opioid - treated cancer patients and to intensify and prolong the analgesia of the opioids as well. In Germany, chlorpromazine still carries label indications for insomnia, severe pruritus, and preanesthesia. Comparison of chlorpromazine to placebo Measured outcome Findings in words Findings in numbers Quality of evidence Global effects Not any improvement ( 9 weeks -- 6 months ) 30 % less risk of having no improvement in mental state, behaviour and functioning RR 0.7 CI 0.6 to 0.9 Very low ( estimate of effect uncertain ) Relapse ( 6 months -- 2 years ) 35 % less risk of relapse RR 0.7 CI 0.5 to 0.9 Adverse effects See also : List of adverse effects for chlorpromazine `` Thorazine shuffle '' redirects here. For the Gov 't Mule song, see Dose ( album ). There appears to be a dose - dependent risk for seizures with chlorpromazine treatment. Tardive dyskinesia and akathisia are less commonly seen with chlorpromazine than they are with high potency typical antipsychotics such as haloperidol or trifluoperazine, and some evidence suggests that, with conservative dosing, the incidence of such effects for chlorpromazine may be comparable to that of newer agents such as risperidone or olanzapine. Chlorpromazine may deposit in ocular tissues when taken in high dosages for long periods of time. Comparison of chlorpromazine to placebo Measured outcome Findings in words Findings in numbers Quality of evidence Adverse effects Weight gain 5 times more likely to have considerable weight gain, around 40 % with chlorpromazine gaining weight RR 4.9 CI 2.3 to 10.4 Very low ( estimate of effect uncertain ) Sedation 3 times more likely to cause sedation, around 30 % with chlorpromazine RR 2.8 CI 2.3 to 3.5 Acute movement disorder 3.5 times more likely to cause easily reversible but unpleasant severe stiffening of muscles, around 6 % with chlorpromazine RR 3.5 CI 1.5 to 8.0 Parkinsonism 2 times more likely to cause parkinsonism ( symptoms such as tremor, hesitancy of movement, decreased facial expression ), around 17 % with chlorpromazine RR 2.1 CI 1.6 to 2.8 Decreased blood pressure with dizziness 3 times more likely to cause decreased blood pressure and dizziness, around 15 % with chlorpromazine RR 2.4 CI 1.7 to 3.3 Contraindications Absolute contraindications include : Circulatory CNS depression Coma Drug intoxication Bone marrow suppression Phaeochromocytoma Hepatic failure Active liver disease Previous hypersensitivity ( including jaundice, agranulocytosis, etc. ) to phenothiazines, especially chlorpromazine, or any of the excipients in the formulation being used. Relative contraindications include : Epilepsy Parkinson 's disease Myasthenia gravis Hypoparathyroidism Prostatic hypertrophy Very rarely, elongation of the QT interval may occur, increasing the risk of potentially fatal arrhythmias. Interactions Consuming food prior to taking chlorpromazine orally limits its absorption, likewise cotreatment with benztropine can also reduce chlorpromazine absorption. Alcohol can also reduce chlorpromazine absorption. Antacids slow chlorpromazine absorption. Lithium and chronic treatment with barbiturates can increase chlorpromazine clearance significantly. Tricyclic antidepressants ( TCAs ) can decrease chlorpromazine clearance and hence increase chlorpromazine exposure. Cotreatment with CYP1A2 inhibitors like ciprofloxacin, fluvoxamine or vemurafenib can reduce chlorpromazine clearance and hence increase exposure and potentially also adverse effects. Chlorpromazine can also potentiate the CNS depressant effects of drugs like barbiturates, benzodiazepines, opioids, lithium and anesthetics and hence increase the potential for adverse effects such as respiratory depression and sedation. It is also a moderate inhibitor of CYP2D6 and also a substrate for CYP2D6 and hence can inhibit its own metabolism. It can also inhibit the clearance of CYP2D6 substrates such as dextromethorphan and hence also potentiate their effects. Other drugs like codeine and tamoxifen which require CYP2D6 - mediated activation into their respective active metabolites may have their therapeutic effects attenuated. Likewise CYP2D6 inhibitors such as paroxetine or fluoxetine can reduce chlorpromazine clearance and hence increase serum levels of chlorpromazine and hence potentially also its adverse effects. Chlorpromazine also reduces phenytoin levels and increases valproic acid levels. It also reduces propranolol clearance and antagonizes the therapeutic effects of antidiabetic agents, levodopa ( a Parkinson 's medication. This is likely due to the fact that chlorpromazine antagonizes the D receptor which is one of the receptors dopamine, a levodopa metabolite, activates ), amphetamines and anticoagulants. It may also interact with anticholinergic drugs such as orphenadrine to produce hypoglycaemia ( low blood sugar ). Chlorpromazine may also interact with epinephrine ( adrenaline ) to produce a paradoxical fall in blood pressure. Monoamine oxidase inhibitors ( MAOIs ) and thiazide diuretics may also accentuate the orthostatic hypotension experienced by those receiving chlorpromazine treatment. Quinidine may interact with chlorpromazine to increase myocardialdepression. Likewise it may also antagonize the effects of clonidine and guanethidine. It also may reduce the seizure threshold and hence a corresponding titration of anticonvulsant treatments should be considered. Prochlorperazine and desferrioxamine may also interact with chlorpromazine to produce transient metabolic encephalopathy. Other drugs that prolong the QT interval such as quinidine, verapamil, amiodarone, sotalol and methadone may also interact with chlorpromazine to produce additive QT interval prolongation. Tolerance and withdrawal The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotic treatment to avoid acute withdrawal syndrome or rapid relapse. While withdrawal symptoms can occur, there is no evidence that tolerance develops to the drug 's antipsychotic effects. A patient can be maintained for years on a therapeutically effective dose without any decrease in effectiveness being reported. Tolerance appears to develop to the sedating effects of chlorpromazine when it is first administered. Tolerance also appears to develop to the extrapyramidal, parkinsonian and other neuroleptic effects, although this is debatable. A failure to notice withdrawal symptoms may be due to the relatively long half life of the drug resulting in the extremely slow excretion from the body. However, there are reports of muscular discomfort, exaggeration of psychotic symptoms and movement disorders, and difficulty sleeping when the antipsychotic drug is suddenly withdrawn, but after years of normal doses these effects are not normally seen. Pharmacology Pharmacokinetics Pharmacokinetic parameters of chlorpromazine Bioavailability Protein bound V Details of metabolism Excretion Notes 10 -- 80 % 1 -- 4 hours ( Oral ) ; 6 -- 24 hours ( IM ) 100 -- 300 ng / mL 90 -- 99 % 10 -- 35 L / kg ( mean : 22 L / kg ) 30 ± 7 hours CYP2D6, CYP1A2 -- mediated into over 10 major metabolites. The major routes of metabolism include hydroxylation, N - oxidation, sulphoxidation, demethylation, deamination and conjugation. There is little evidence supporting the development of metabolic tolerance or an increase in the metabolism of chlorpromazine due to microsomal liver enzymes following multiple doses of the drug. Urine ( 43 -- 65 % after 24 hours ) Its high degree of lipophilicity ( fat solubility ) allows it to be detected in the urine for up to 18 months. Less than 1 % of the unchanged drug is excreted via the kidneys in the urine, in which 20 -- 70 % is excreted as conjugated or unconjugated metabolites, whereas 5 -- 6 % is excreted in feces. Three common metabolites of chlorpromazine Pharmacodynamics Chlorpromazine is a very effective antagonist of D2 dopamine receptors and similar receptors, such as D3 and D5. Unlike most other drugs of this genre, it also has a high affinity for D1 receptors. Blocking these receptors causes diminished neurotransmitter binding in the forebrain, resulting in many different effects. Dopamine, unable to bind with a receptor, causes a feedback loop that causes dopaminergic neurons to release more dopamine. Therefore, upon first taking the drug, patients will experience an increase in dopaminergic neural activity. Eventually, dopamine production of the neurons will drop substantially and dopamine will be removed from the synaptic cleft. At this point, neural activity decreases greatly ; the continual blockade of receptors only compounds this effect. Chlorpromazine acts as an antagonist ( blocking agent ) on different postsynaptic and presynaptic receptors : Dopamine receptors ( subtypes D, D, D and D ), which account for its different antipsychotic properties on productive and unproductive symptoms, in the mesolimbic dopamine system accounts for the antipsychotic effect whereas the blockade in the nigrostriatal system produces the extrapyramidal effects Serotonin receptors ( 5 - HT and 5 - HT ), with anxiolytic, and antiaggressive properties as well as an attenuation of extrapyramidal side effects, but also leading to weight gain and ejaculation difficulties. Histamine receptors ( H receptors, accounting for sedation, antiemetic effect, vertigo, and weight gain ) α - and α - adrenergic receptors ( accounting for sympatholytic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism -- controversial. Also associated with weight gain as a result of blockage of the adrenergic alpha 1 receptor ) M and M muscarinic acetylcholine receptors ( causing anticholinergic symptoms such as dry mouth, blurred vision, constipation, difficulty or inability to urinate, sinus tachycardia, electrocardiographic changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side effects ). The presumed effectiveness of the antipsychotic drugs relied on their ability to block dopamine receptors. This assumption arose from the dopamine hypothesis that maintains that both schizophrenia and bipolar disorder are a result of excessive dopamine activity. Furthermore, psychomotor stimulants like cocaine that increase dopamine levels can cause psychotic symptoms if taken in excess. Chlorpromazine and other typical antipsychotics are primarily blockers of D2 receptors. In fact an almost perfect correlation exists between the therapeutic dose of a typical antipsychotic and the drug 's affinity for the D2 receptor. Therefore, a larger dose is required if the drug 's affinity for the D2 receptor is relatively weak. A correlation exists between average clinical potency and affinity of the antipsychotics for dopamine receptors. Chlorpromazine tends to have greater effect at serotonin receptors than at D2 receptors, which is notably the opposite effect of the other typical antipsychotics. Therefore, chlorpromazine with respect to its effects on dopamine and serotonin receptors is more similar to the atypical antipsychotics than to the typical antipsychotics. Chlorpromazine and other antipsychotics with sedative properties such as promazine and thioridazine are among the most potent agents at α - adrenergic receptors. Furthermore, they are also among the most potent antipsychotics at histamine H1 receptors. This finding is in agreement with the pharmaceutical development of chlorpromazine and other antipsychotics as anti-histamine agents. Furthermore, the brain has a higher density of histamine H1 receptors than any body organ examined which may account for why chlorpromazine and other phenothiazine antipsychotics are as potent at these sites as the most potent classical antihistamines. In addition to influencing the neurotransmitters dopamine, serotonin, epinephrine, norepinephrine, and acetylcholine it has been reported that antipsychotic drugs could achieve glutamanergic effects. This mechanism involves direct effects on antipsychotic drugs on glutamate receptors. By using the technique of functional neurochemical assay chlorpromazine and phenothiazine derivatives have been shown to have inhibitory effects on NMDA receptors that appeared to be mediated by action at the Zn site. It was found that there is an increase of NMDA activity at low concentrations and suppression at high concentrations of the drug. No significant difference in glutamate and glycine activity from the effects of chlorpromazine were reported. Further work will be necessary to determine if the influence in NMDA receptors by antipsychotic drugs contributes to their effectiveness. Chlorpromazine does also act as FIASMA ( functional inhibitor of acid sphingomyelinase ). Peripheral effects Chlorpromazine is an antagonist to H receptors ( provoking antiallergic effects ), H receptors ( reduction of forming of gastric juice ), M and M receptors ( dry mouth, reduction in forming of gastric juice ) and some 5 - HT receptors ( different anti-allergic / gastrointestinal actions ). Because it acts on so many receptors, chlorpromazine is often referred to as a `` dirty drug ''. History Advertisement for Thorazine ( chlorpromazine ) from the early 1960s In 1933, the French pharmaceutical company Laboratoires Rhône - Poulenc began to search for new anti-histamines. In 1947, it synthesized promethazine, a phenothiazine derivative, which was found to have more pronounced sedative and antihistaminic effects than earlier drugs. A year later, the French surgeon Pierre Huguenard used promethazine together with pethidine as part of a cocktail to induce relaxation and indifference in surgical patients. Another surgeon, Henri Laborit, believed the compound stabilized the central nervous system by causing `` artificial hibernation '', and described this state as `` sedation without narcosis ''. He suggested to Rhône - Poulenc that they develop a compound with better stabilizing properties. In December 1950, the chemist Paul Charpentier produced a series of compounds that included RP4560 or chlorpromazine. Simone Courvoisier conducted behavioural tests and found chlorpromazine produced indifference to aversive stimuli in rats. Chlorpromazine was distributed for testing to physicians between April and August 1951. Laborit trialled the medicine on at the Val - de-Grâce military hospital in Paris, using it as an anaesthetic booster in intravenous doses of 50 to 100 mg on surgery patients and confirming it as the best drug to date in calming and reducing shock, with patients reporting improved well being afterwards. He also noted its hypothermic effect and suggested it may induce artificial hibernation. Laborit thought this would allow the body to better tolerate major surgery by reducing shock, a novel idea at the time. Known colloquially as `` Laborit 's drug '', chlorpromazine was released onto the market in 1953 by Rhône - Poulenc and given the trade name Largactil, derived from large `` broad '' and acti * `` activity. Following on, Laborit considered whether chlorpromazine may have a role in managing patients with severe burns, Raynaud 's phenomenon, or psychiatric disorders. At the Villejuif Mental Hospital in November 1951, he and Montassut administered an intravenous dose to psychiatrist Cornelia Quarti who was acting as a volunteer. Quarti noted the indifference, but fainted upon getting up to go to the toilet, and so further testing was discontinued ( orthostatic hypotension is a possible side effect of chlorpromazine ). Despite this, Laborit continued to push for testing in psychiatric patients during early 1952. Psychiatrists were reluctant initially, but on January 19, 1952, it was administered ( alongside pethidine, pentothal and ECT ) to Jacques Lh. a 24 - year - old manic patient, who responded dramatically, and was discharged after three weeks having received 855 mg of the drug in total. Pierre Deniker had heard about Laborit 's work from his brother - in - law, who was a surgeon, and ordered chlorpromazine for a clinical trial at the Sainte - Anne Hospital Center in Paris where he was Men 's Service Chief. Together with the Director of the hospital, Professor Jean Delay, they published their first clinical trial in 1952, in which they treated 38 psychotic patients with daily injections of chlorpromazine without the use of other sedating agents. The response was dramatic ; treatment with chlorpromazine went beyond simple sedation with patients showing improvements in thinking and emotional behaviour. They also found that doses higher than those used by Laborit were required, giving patients 75 -- 100 mg daily. Deniker then visited America, where the publication of their work alerted the American psychiatric community that the new treatment might represent a real breakthrough. Heinz Lehmann of the Verdun Protestant Hospital in Montreal trialled it in 70 patients and also noted its striking effects, with patients ' symptoms resolving after many years of unrelenting psychosis. By 1954, chlorpromazine was being used in the United States to treat schizophrenia, mania, psychomotor excitement, and other psychotic disorders. Rhône - Poulenc licensed chlorpromazine to Smith Kline & French ( today 's GlaxoSmithKline ) in 1953. In 1955 it was approved in the United States for the treatment of emesis ( vomiting ). The effect of this drug in emptying psychiatric hospitals has been compared to that of penicillin and infectious diseases. But the popularity of the drug fell from the late 1960s as newer drugs came on the scene. From chlorpromazine a number of other similar antipsychotics were developed. It also led to the discovery of antidepressants. Chlorpromazine largely replaced electroconvulsive therapy, hydrotherapy, psychosurgery, and insulin shock therapy. By 1964, about 50 million people worldwide had taken it. Chlorpromazine, in widespread use for 50 years, remains a `` benchmark '' drug in the treatment of schizophrenia, an effective drug although not a perfect one. The relative strengths or potencies of other antipsychotics are often ranked or measured against chlorpromazine in aliquots of 100 mg, termed chlorpromazine equivalents or CPZE. Brand names Brand names include Thorazine, Largactil, Hibernal, and Megaphen ( sold by Bayer in West - Germany since July 1953 ). Veterinary use The veterinary use of chlorpromazine has generally been superseded by use of acepromazine. Chlorpromazine may be used as an antiemetic in dogs and cats, or, less often, as sedative prior to anesthesia. In horses, it often causes ataxia and lethargy, and is therefore seldom used. It is commonly used to decrease nausea in animals that are too young for other common anti-emetics. 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( 2000 ). `` Chlorpromazine equivalents and percentage of British National Formulary maximum recommended dose in patients receiving high - dose antipsychotics ''. Psychiatric Bulletin. 24 ( 4 ) : 130 -- 132. doi : 10.1192 / pb. 24.4. 130. Jump up ^ Bangen, Hans ( 1992 ). Geschichte der medikamentösen Therapie der Schizophrenie. Verlag für Wissenschaft und Bildung. p. 98. ISBN 3 - 927 - 408 - 82 - 4. ^ Jump up to : Plumb, Donald C. ( 9 February 2015 ). Plumb 's Veterinary Drug Handbook ( 8th ed. ). John Wiley & Sons. ISBN 111891192X. ^ Jump up to : Posner, Lysa A. ; Burns, Patrick ( 2009 ). `` Chapter 13 : Sedative agents : tranquilizers, alpha - 2 agonists, and related agents ''. In Riviere, Jim E. ; Papich, Mark G. ; Adams, Richard H. Veterinary pharmacology and therapeutics ( 9 ed. ). Ames, Iowa : Wiley - Blackwell. pp. 337 -- 380. ISBN 9780813820613. Jump up ^ `` Chlorpromazine : summary report '' ( PDF ). European Medicines Agency. Committee for Veterinary Medicinal Products. 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External links U.S. National Library of Medicine : Drug Information Portal -- Chlorpromazine Antipsychotics ( N05A ) Typical Butyrophenones : Benperidol Bromperidol Droperidol Haloperidol Moperone Pipamperone Spiperone Timiperone Trifluperidol Diphenylbutylpiperidines : Fluspirilene Penfluridol Pimozide Phenothiazines : Acetophenazine Butaperazine Carphenazine ( carfenazine ) Chlorpromazine Cyamemazine Dixyrazine Fluphenazine Levomepromazine ( methotrimeprazine ) Mesoridazine Perazine Periciazine Perphenazine Piperacetazine Pipotiazine Prochlorperazine Promazine Sulforidazine Thiopropazate Thioproperazine Thioridazine Trifluoperazine Triflupromazine Thioxanthenes : Chlorprothixene Clopenthixol Flupentixol Tiotixene ( thiothixene ) Zuclopenthixol Disputed Benzamides : Amisulpride Levosulpiride Nemonapride Remoxipride Sulpiride Sultopride Tiapride Veralipride Butyrophenones : Melperone Tricyclics : Carpipramine Clocapramine Clorotepine Clotiapine Loxapine Mosapramine Others : Molindone Atypical Benzisoxazole / benzisothiazoles : Iloperidone Lurasidone Paliperidone Paliperidone palmitate Perospirone Risperidone Ziprasidone Butyrophenones : Lumateperone Phenylpiperazines / quinolinones : Aripiprazole Aripiprazole lauroxil Brexpiprazole Cariprazine RP - 5063 Tricyclics : Asenapine Clozapine Olanzapine Quetiapine Zotepine Others : Blonanserin Pimavanserin Sertindole Others Azacyclonol Cannabidiol Oxypertine Reserpine Tetrabenazine WHO - EM Withdrawn from market Clinical trials : Phase III Never to phase III Pharmacodynamics Adrenergic receptor modulators α Agonists : 6 - FNE Amidephrine Anisodine Buspirone Cirazoline Corbadrine Desglymidodrine Dexisometheptene Dipivefrine Dopamine Droxidopa ( L - DOPS ) Ephedrine Epinephrine Etilefrine Etilevodopa Ethylnorepinephrine Indanidine Isometheptene L - DOPA ( levodopa ) L - Phenylalanine L - Tyrosine Melevodopa Metaraminol Methoxamine Methyldopa Midodrine Naphazoline Norepinephrine Octopamine ( drug ) Oxymetazoline Phenylephrine Phenylpropanolamine Pseudoephedrine Synephrine Tetryzoline Tiamenidine XP21279 Xylometazoline Antagonists : Abanoquil Adimolol Ajmalicine Alfuzosin Amosulalol Anisodamine Arotinolol Atiprosin Atypical antipsychotics ( e.g., brexpiprazole, clozapine, olanzapine, quetiapine, risperidone ) Benoxathian Buflomedil Bunazosin Carvedilol Corynanthine Dapiprazole Domesticine Doxazosin Ergolines ( e.g., ergotamine, dihydroergotamine, lisuride, terguride ) Etoperidone Eugenodilol Fenspiride Hydroxyzine Indoramin Ketanserin L - 765,314 Labetalol mCPP Mepiprazole Metazosin Monatepil Moxisylyte Naftopidil Nantenine Neldazosin Niaprazine Nicergoline Niguldipine Pardoprunox Pelanserin Perlapine Phendioxan Phenoxybenzamine Phentolamine Phenylpiperazine antidepressants ( e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Piperoxan Prazosin Quinazosin Quinidine Ritanserin Silodosin Spiperone Talipexole Tamsulosin Terazosin Tiodazosin Tolazoline Tetracyclic antidepressants ( e.g., amoxapine, maprotiline, mianserin ) Tricyclic antidepressants ( e.g., amitriptyline, clomipramine, doxepin, imipramine, trimipramine ) Trimazosin Typical antipsychotics ( e.g., chlorpromazine, fluphenazine, loxapine, thioridazine ) Urapidil WB - 4101 Zolertine α Agonists : ( R ) - 3 - Nitrobiphenyline 4 - NEMD 6 - FNE Amitraz Apraclonidine Brimonidine Cannabivarin Clonidine Corbadrine Detomidine Dexmedetomidine Dihydroergotamine Dipivefrine Dopamine Droxidopa ( L - DOPS ) Etilevodopa Ephedrine Ergotamine Epinephrine Etilefrine Ethylnorepinephrine Guanabenz Guanfacine Guanoxabenz L - DOPA ( levodopa ) L - Phenylalanine L - Tyrosine Lofexidine Medetomidine Melevodopa Methyldopa Mivazerol Naphazoline Norepinephrine Oxymetazoline Phenylpropanolamine Piperoxan Pseudoephedrine Rezatomidine Rilmenidine Romifidine Talipexole Tasipimidine Tetrahydrozoline Tiamenidine Tizanidine Tolonidine Urapidil Vatinoxan XP21279 Xylazine Xylometazoline Antagonists : 1 - PP Adimolol Amesergide Aptazapine Atipamezole Atypical antipsychotics ( e.g., asenapine, brexpiprazole, clozapine, lurasidone, paliperidone, quetiapine, risperidone, zotepine ) Azapirones ( e.g., buspirone, gepirone, ipsapirone, tandospirone ) BRL - 44408 Buflomedil Cirazoline Efaroxan Esmirtazapine Fenmetozole Fluparoxan Idazoxan mCPP Mianserin Mirtazapine NAN - 190 Olanzapine Pardoprunox Phentolamine Phenoxybenzamine Piperoxan Piribedil Rauwolscine Rotigotine SB - 269970 Setiptiline Spiroxatrine Sunepitron Tolazoline Typical antipsychotics ( e.g., chlorpromazine, fluphenazine, loxapine, thioridazine ) Yohimbine β Agonists : Abediterol Alifedrine Amibegron Arbutamine Arformoterol Arotinolol BAAM Bambuterol Befunolol Bitolterol Broxaterol Buphenine Carbuterol Carmoterol Cimaterol Clenbuterol Colterol Corbadrine Denopamine Dipivefrine Dobutamine Dopamine Dopexamine Droxidopa ( L - DOPS ) Ephedrine Epinephrine Etafedrine Etilefrine Etilevodopa Ethylnorepinephrine Fenoterol Formoterol Hexoprenaline Higenamine Indacaterol Isoetarine Isoprenaline Isoxsuprine L - DOPA ( levodopa ) L - Phenylalanine L - Tyrosine Levosalbutamol Mabuterol Melevodopa Methoxyphenamine Methyldopa Mirabegron Norepinephrine Orciprenaline Oxyfedrine PF - 610355 Phenylpropanolamine Pirbuterol Prenalterol Ractopamine Procaterol Pseudoephedrine Reproterol Rimiterol Ritodrine Salbutamol Salmeterol Solabegron Terbutaline Tretoquinol Tulobuterol Vilanterol Xamoterol XP21279 Zilpaterol Zinterol Antagonists : Acebutolol Adaprolol Adimolol Afurolol Alprenolol Alprenoxime Amosulalol Ancarolol Arnolol Arotinolol Atenolol Befunolol Betaxolol Bevantolol Bisoprolol Bopindolol Bornaprolol Brefonalol Bucindolol Bucumolol Bufetolol Bufuralol Bunitrolol Bunolol Bupranolol Butaxamine Butidrine Butofilolol Capsinolol Carazolol Carpindolol Carteolol Carvedilol Celiprolol Cetamolol Cicloprolol Cinamolol Cloranolol Cyanopindolol Dalbraminol Dexpropranolol Diacetolol Dichloroisoprenaline Dihydroalprenolol Dilevalol Diprafenone Draquinolol Ecastolol Epanolol Ericolol Ersentilide Esatenolol Esprolol Eugenodilol Exaprolol Falintolol Flestolol Flusoxolol Hydroxycarteolol Hydroxytertatolol ICI - 118,551 Idropranolol Indenolol Indopanolol Iodocyanopindolol Iprocrolol Isoxaprolol Isamoltane Labetalol Landiolol Levobetaxolol Levobunolol Levomoprolol Medroxalol Mepindolol Metipranolol Metoprolol Moprolol Nadolol Nadoxolol Nebivolol Nifenalol Nipradilol Oxprenolol Pacrinolol Pafenolol Pamatolol Pargolol Penbutolol Pindolol Practolol Primidolol Procinolol Pronethalol Propafenone Propranolol Ridazolol Ronactolol Soquinolol Sotalol Spirendolol SR 59230A Sulfinalol Talinolol Tazolol Tertatolol Tienoxolol Tilisolol Timolol Tiprenolol Tolamolol Toliprolol Xibenolol Xipranolol Dopamine receptor modulators D - like Agonists Benzazepines : 6 - Br - APB Fenoldopam SKF - 38,393 SKF - 77,434 SKF - 81,297 SKF - 82,958 SKF - 83,959 Trepipam Zelandopam Ergolines : Cabergoline CY - 208,243 Dihydroergocryptine LEK - 8829 Lisuride Pergolide Terguride Dihydrexidine derivatives : A-77636 A-86929 Adrogolide ( ABT - 431, DAS - 431 ) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines : BCO - 001 Deoxyepinephrine ( N - methyldopamine, epinine ) Dopexamine Etilevodopa Ibopamine L - DOPA ( levodopa ) Melevodopa L - Phenylalanine L - Tyrosine XP21279 Others : A-68930 Apomorphine Isocorypalmine Nuciferine PF - 6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF - 89,145 SKF - 89,626 Stepholidine Tetrahydropalmatine Antagonists Typical antipsychotics : Butaclamol Chlorpromazine Chlorprothixene Flupentixol ( flupenthixol ) ( + melitracen ) Fluphenazine Loxapine Perphenazine ( + amitriptyline ) Pifluthixol Thioridazine Thiothixene Trifluoperazine ( + tranylcypromine ) Zuclopenthixol Atypical antipsychotics : Asenapine Clorotepine Clotiapine Clozapine DHA - clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine ( + + fluoxetine ) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others : Berupipam Ecopipam EEDQ Metitepine ( methiothepin ) Odapipam Perlapine SCH - 23390 D - like Agonists Adamantanes : Amantadine Memantine Rimantadine Aminotetralins : 5 - OH - DPAT 7 - OH - DPAT 8 - OH - PBZI Rotigotine UH - 232 Ergolines : Bromocriptine Cabergoline Dihydroergocryptine Epicriptine Ergocornine Lisuride LSD Pergolide Terguride Dihydrexidine derivatives : 2 - OH - NPA Ciladopa Dihydrexidine Dinoxyline N, N - Propyldihydrexidine Phenethylamines : Deoxyepinephrine ( N - methyldopamine, epinine ) Dopexamine Etilevodopa Ibopamine L - DOPA ( levodopa ) L - Phenylalanine L - Tyrosine Melevodopa XP21279 Atypical antipsychotics : Alentemol ( U-66444B ) Aripiprazole ( + sertraline ) Aripiprazole lauroxil Bifeprunox Brexpiprazole Cariprazine F - 15063 Lumateperone Norclozapine RP - 5063 Others : 3 - PPP A-412997 ABT - 670 ABT - 724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP - 897 Captodiame CP - 226,269 Dizocilpine Esketamine Flibanserin GSK - 789,472 Ketamine Mesulergine Modafinil OSU - 6162 Pardoprunox PD - 128,907 PD - 168,077 PF - 219,061 PF - 592,379 Phencyclidine Piribedil Pramipexole Preclamol Propylnorapomorphine Pukateine Quinagolide Quinelorane Quinpirole RDS - 127 Ro10 - 5824 Ropinirole Roxindole Salvinorin A SKF - 83,959 Sumanirole Talipexole Umespirone WAY - 100,635 Antagonists Typical antipsychotics : Acepromazine Acetophenazine Azaperone Benperidol Bromperidol Butaclamol Butaperazine Chloracizine Chlorproethazine Chlorpromazine Chlorprothixene Ciclindole Clopenthixol Clothixamide Clopimozide Droperidol Fluacizine Fluanisone Flucindole Fluotracen Flupentixol ( flupenthixol ) ( + melitracen ) Fluphenazine Fluprothixene Fluspirilene Haloperidol Homopipramol Lenperone Levomepromazine ( methotrimeprazine ) Levosulpiride Loxapine Mesoridazine Moperone Naranol Nemonapride Penfluridol Perathiepin Perazine Pericyazine ( periciazine ) Perphenazine ( + amitriptyline ) Piflutixol ( pifluthixol ) Pimozide Pipamperone Preclamol Prochlorperazine Promazine Prothipendyl Spiperone ( spiroperidol ) Sulforidazine Sulpiride Sultopride Teflutixol Thiopropazate Thioproperazine Thioridazine Thiothixene Timiperone Trifluoperazine ( + tranylcypromine ) Triflupromazine Trifluperidol Zetidoline Zuclopenthixol Atypical antipsychotics : Amisulpride Asenapine BL - 1020 Blonanserin Carpipramine Cinuperone Clocapramine Clorotepine Clotiapine ( clothiapine ) Clozapine Cyamemazine DHA - clozapine Dixyrazine Elopiprazole Flumezapine Fluperlapine Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine ( + fluoxetine ) Paliperidone Perospirone Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone Zotepine Antiemetics / gastroprokinetics / sedatives : Aceprometazine AS - 8112 Alimemazine Alizapride Benzquinamide Bromopride Clebopride Domperidone Eticlopride Hydroxyzine Itopride Metoclopramide Metopimazine Promethazine Thiethylperazine Trimethobenzamide Antidepressants : Amoxapine Nefazodone Opipramol Propiomazine Trimipramine Others : 3 - PPP Alpiropride Azapride Buspirone Desmethoxyfallypride EEDQ F - 15063 Fallypride Fananserin Fenfluramine GSK - 789,472 Iodobenzamide Isocorypalmine L - 741,626 L - 745,870 Levofenfluramine LEK - 8829 Metergoline Metitepine ( methiothepin ) N - Methylspiperone Nafadotride Nuciferine PNU - 99,194 Pridopidine Raclopride Sarizotan SB - 277,011 - A Seridopidine Sonepiprazole Spiroxatrine Stepholidine SV - 293 Tetrahydropalmatine Tiapride UH - 232 Yohimbine See also : Receptor / signaling modulators Adrenergics Serotonergics Monoamine reuptake inhibitors Monoamine releasing agents Monoamine metabolism modulators Monoamine neurotoxins Histamine receptor modulators Agonists : 2 - Pyridylethylamine Betahistine Histamine HTMT L - Histidine UR - AK49 Antagonists : First - generation : 4 - Methyldiphenhydramine Alimemazine Antazoline Azatadine Bamipine Benzatropine ( benztropine ) Bepotastine Bromazine Brompheniramine Buclizine Captodiame Carbinoxamine Chlorcyclizine Chloropyramine Chlorothen Chlorphenamine Chlorphenoxamine Cinnarizine Clemastine Clobenzepam Clocinizine Cloperastine Cyclizine Cyproheptadine Dacemazine Decloxizine Deptropine Dexbrompheniramine Dexchlorpheniramine Dimenhydrinate Dimetindene Diphenhydramine Diphenylpyraline Doxylamine Embramine Etodroxizine Etybenzatropine ( ethylbenztropine ) Etymemazine Fenethazine Flunarizine Histapyrrodine Homochlorcyclizine Hydroxyethylpromethazine Hydroxyzine Isopromethazine Isothipendyl Meclozine Medrylamine Mepyramine ( pyrilamine ) Mequitazine Methafurylene Methapyrilene Methdilazine Moxastine Orphenadrine Oxatomide Oxomemazine Perlapine Phenindamine Pheniramine Phenyltoloxamine Pimethixene Piperoxan Pipoxizine Promethazine Propiomazine Pyrrobutamine Talastine Thenalidine Thenyldiamine Thiazinamium Thonzylamine Tolpropamine Tripelennamine Triprolidine Second / third - generation : Acrivastine Alinastine Astemizole Azelastine Bamirastine Barmastine Bepiastine Bepotastine Bilastine Cabastinen Carebastine Cetirizine Clemastine Clemizole Clobenztropine Desloratadine Dorastine Ebastine Efletirizine Emedastine Epinastine Fexofenadine Flezelastine Ketotifen Latrepirdine Levocabastine Levocetirizine Linetastine Loratadine Mapinastine Mebhydrolin Mizolastine Moxastine Noberastine Octastine Olopatadine Perastine Pibaxizine Piclopastine Quifenadine ( phencarol ) Rocastine Rupatadine Setastine Sequifenadine ( bicarphen ) Talastine Temelastine Terfenadine Vapitadine Zepastine Others : Atypical antipsychotics ( e.g., aripiprazole, asenapine, brexpiprazole, clozapine, iloperidone, olanzapine, paliperidone, quetiapine, risperidone, RP - 5063, ziprasidone, zotepine ) Phenylpiperazine antidepressants ( e.g., hydroxynefazodone, nefazodone, trazodone, triazoledione ) Tetracyclic antidepressants ( e.g., amoxapine, loxapine, maprotiline, mianserin, mirtazapine, oxaprotiline ) Tricyclic antidepressants ( e.g., amitriptyline, butriptyline, clomipramine, desipramine, dosulepin ( dothiepin ), doxepin, imipramine, iprindole, lofepramine, nortriptyline, protriptyline, trimipramine ) Typical antipsychotics ( e.g., chlorpromazine, flupenthixol, fluphenazine, loxapine, perphenazine, prochlorperazine, thioridazine, thiothixene ) Unknown / unsorted : Azanator Belarizine Elbanizine Flotrenizine Napactadine Tagorizine Trelnarizine Trenizine Agonists : Amthamine Betazole Dimaprit Histamine HTMT Impromidine L - Histidine UR - AK49 Antagonists : Bisfentidine Burimamide Cimetidine Dalcotidine Donetidine Ebrotidine Etintidine Famotidine Isolamtidine Lafutidine Lamtidine Lavoltidine ( loxtidine ) Lupitidine Metiamide Mifentidine Niperotidine Nizatidine Osutidine Oxmetidine Pibutidine Quisultazine ( quisultidine ) Ramixotidine Ranitidine Roxatidine Sufotidine Tiotidine Tuvatidine Venritidine Xaltidine Zolantidine Agonists : α - Methylhistamine Cipralisant Histamine Imetit Immepip Immethridine L - Histidine Methimepip Proxyfan Antagonists : A-349,821 A-423,579 ABT - 239 ABT - 652 AZD5213 Bavisant Betahistine Burimamide Ciproxifan Clobenpropit Conessine Enerisant GSK - 189,254 Impentamine Iodophenpropit Irdabisant JNJ - 5207852 MK - 0249 NNC 38 - 1049 PF - 03654746 Pitolisant SCH - 79687 Thioperamide VUF - 5681 Agonists : 4 - Methylhistamine α - Methylhistamine Histamine L - Histidine OUP - 16 VUF - 8430 Antagonists : JNJ - 7777120 Mianserin Seliforant Thioperamide Toreforant VUF - 6002 See also : Receptor / signaling modulators Monoamine metabolism modulators Monoamine reuptake inhibitors Muscarinic acetylcholine receptor modulators mAChRs Agonists 77 - LH - 28 - 1 AC - 42 AC - 260,584 Aceclidine Acetylcholine AF30 AF150 ( S ) AF267B Alvameline AQRA - 741 Arecoline Bethanechol Bevonium Butyrylcholine Carbachol CDD - 0034 CDD - 0078 CDD - 0097 CDD - 0098 CDD - 0102 Cevimeline Choline cis - Dioxolane Clozapine Desmethylclozapine ( norclozapine ) Ethoxysebacylcholine Itameline LY - 593,039 L - 689,660 LY - 2,033,298 McNA343 Methacholine Milameline Muscarine NGX - 267 Ocvimeline Oxotremorine PD - 151,832 Pilocarpine RS86 Sabcomeline SDZ 210 - 086 Sebacylcholine Suberyldicholine Talsaclidine Tazomeline Thiopilocarpine Vedaclidine VU - 0029767 VU - 0090157 VU - 0152099 VU - 0152100 VU - 0238429 WAY - 132,983 Xanomeline YM - 796 Antagonists 3 - Quinuclidinyl benzilate 4 - DAMP Aclidinium bromide ( + formoterol ) Abediterol AF - DX 250 AF - DX 384 Ambutonium bromide Anisodamine Anisodine Antihistamines ( first - generation ) ( e.g., brompheniramine, buclizine, captodiame, chlorphenamine ( chlorpheniramine ), cinnarizine, clemastine, cyproheptadine, dimenhydrinate, dimetindene, diphenhydramine, doxylamine, meclizine, mepyramine ( pyrilamine ), mequitazine, perlapine, phenindamine, pheniramine, phenyltoloxamine, promethazine, propiomazine, triprolidine ) AQ - RA 741 Atropine Atropine methonitrate Atypical antipsychotics ( e.g., clozapine, fluperlapine, olanzapine ( + fluoxetine ), rilapine, quetiapine, tenilapine, zotepine ) Benactyzine Benzatropine ( benztropine ) Benzilone Benzilylcholine mustard Benzydamine BIBN 99 Biperiden Bornaprine Camylofin CAR - 226,086 CAR - 301,060 CAR - 302,196 CAR - 302,282 CAR - 302,368 CAR - 302,537 CAR - 302,668 Caramiphen Cimetropium bromide Clidinium bromide Cloperastine CS - 27349 Cyclobenzaprine Cyclopentolate Darifenacin DAU - 5884 Desfesoterodine Dexetimide DIBD Dicycloverine ( dicyclomine ) Dihexyverine Difemerine Diphemanil metilsulfate Ditran EA - 3167 EA - 3443 EA - 3580 EA - 3834 Emepronium bromide Etanautine Etybenzatropine ( ethybenztropine ) Fenpiverinium Fentonium Fesoterodine Flavoxate Glycopyrronium bromide ( + beclometasone / formoterol, + indacaterol ) Hexahydrodifenidol Hexahydrosiladifenidol Hexbutinol Hexocyclium Himbacine HL - 031,120 Homatropine Imidafenacin Ipratropium bromide ( + salbutamol ) Isopropamide J - 104,129 Hyoscyamine Mamba toxin 3 Mamba toxin 7 Mazaticol Mebeverine Meladrazine Mepenzolate Methantheline Methoctramine Methylatropine Methylhomatropine Methylscopolamine Metixene Muscarinic toxin 7 N - Ethyl - 3 - piperidyl benzilate N - Methyl - 3 - piperidyl benzilate Nefopam Octatropine methylbromide ( anisotropine methylbromide ) Orphenadrine Otenzepad ( AF - DX 116 ) Otilonium bromide Oxapium iodide Oxitropium bromide Oxybutynin Oxyphencyclimine Oxyphenonium bromide PBID PD - 102,807 PD - 0298029 Penthienate Pethidine pFHHSiD Phenglutarimide Phenyltoloxamine Pipenzolate bromide Piperidolate Pirenzepine Piroheptine Pizotifen Poldine Pridinol Prifinium bromide Procyclidine Profenamine ( ethopropazine ) Propantheline bromide Propiverine Quinidine Revefenacin Rociverine RU - 47,213 SCH - 57,790 SCH - 72,788 SCH - 217,443 Scopolamine ( hyoscine ) Scopolamine butylbromide ( hyoscine butylbromide ) Silahexacyclium Sofpironium bromide Solifenacin SSRIs ( e.g., femoxetine, paroxetine ) Telenzepine Terodiline Tetracyclic antidepressants ( e.g., amoxapine, maprotiline, mianserin, mirtazapine ) Tiemonium iodide Timepidium bromide Tiotropium bromide Tiquizium bromide Tofenacin Tolterodine Tricyclic antidepressants ( e.g., amitriptyline ( + perphenazine ), amitriptylinoxide, butriptyline, cidoxepin, clomipramine, desipramine, desmethyldesipramine, dibenzepin, dosulepin ( dothiepin ), doxepin, imipramine, lofepramine, nitroxazepine, northiaden ( desmethyldosulepin ), nortriptyline, protriptyline, quinupramine, trimipramine ) Tridihexethyl Trihexyphenidyl Trimebutine Tripitamine ( tripitramine ) Tropacine Tropatepine Tropicamide Trospium chloride Typical antipsychotics ( e.g., chlorpromazine, chlorprothixene, cyamemazine ( cyamepromazine ), loxapine, mesoridazine, thioridazine ) Umeclidinium bromide ( + vilanterol ) WIN - 2299 Xanomeline Zamifenacin Precursors ( and prodrugs ) Acetyl - coA Adafenoxate Choline ( lecithin ) Citicoline Cyprodenate Dimethylethanolamine Glycerophosphocholine Meclofenoxate ( centrophenoxine ) Phosphatidylcholine Phosphatidylethanolamine Phosphorylcholine Pirisudanol See also : Receptor / signaling modulators Nicotinic acetylcholine receptor modulators Acetylcholine metabolism / transport modulators Serotonin receptor modulators 5 - HT 5 - HT Agonists : 8 - OH - DPAT Adatanserin Amphetamine Antidepressants ( e.g., etoperidone, hydroxynefazodone, nefazodone, trazodone, triazoledione, vilazodone, vortioxetine ) Atypical antipsychotics ( e.g., aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, lurasidone, quetiapine, ziprasidone ) Azapirones ( e.g., buspirone, eptapirone, gepirone, perospirone, tandospirone ) Bay R 1531 Befiradol BMY - 14802 Cannabidiol Dimemebfe Dopamine Ebalzotan Eltoprazine Enciprazine Ergolines ( e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, lisuride, LSD, methylergometrine ( methylergonovine ), methysergide, pergolide ) F - 11461 F - 12826 F - 13714 F - 14679 F - 15063 F - 15599 Flesinoxan Flibanserin Flumexadol Lesopitron LY - 293284 LY - 301317 mCPP MKC - 242 Naluzotan NBUMP Osemozotan Oxaflozane Pardoprunox Piclozotan Rauwolscine Repinotan Roxindole RU - 24969 S - 14506 S - 14671 S - 15535 Sarizotan Serotonin ( 5 - HT ) SSR - 181507 Sunepitron Tryptamines ( e.g., 5 - CT, 5 - MeO - DMT, 5 - MT, bufotenin, DMT, indorenate, N - Me - 5 - HT, psilocin, psilocybin ) TGBA01AD U-92016A Urapidil Vilazodone Xaliproden Yohimbine Antagonists : Atypical antipsychotics ( e.g., iloperidone, risperidone, sertindole ) AV965 Beta blockers ( e.g., alprenolol, carteolol, cyanopindolol, iodocyanopindolol, isamoltane, oxprenolol, penbutolol, pindobind, pindolol, propranolol, tertatolol ) BMY - 7378 CSP - 2503 Dotarizine Ergolines ( e.g., metergoline ) Flopropione GR - 46611 Isamoltane Lecozotan Mefway Metitepine ( methiothepin ) MIN - 117 ( WF - 516 ) MPPF NAN - 190 Robalzotan S - 15535 SB - 649915 SDZ 216 - 525 Spiperone Spiramide Spiroxatrine UH - 301 WAY - 100135 WAY - 100635 Xylamidine Unknown / unsorted : Acetryptine Ergolines ( e.g., ergometrine ( ergonovine ) ) 5 - HT Agonists : CGS - 12066A CP - 93129 CP - 94253 CP - 122,288 CP - 135807 Eltoprazine Ergolines ( e.g., bromocriptine, dihydroergotamine, ergotamine, methylergometrine ( methylergonovine ), methysergide, pergolide ) mCPP RU - 24969 Serotonin ( 5 - HT ) Triptans ( e.g., avitriptan, donitriptan, eletriptan, sumatriptan, zolmitriptan ) TFMPP Tryptamines ( e.g., 5 - BT, 5 - CT, 5 - MT, DMT ) Vortioxetine Antagonists : AR - A000002 Beta blockers ( e.g., alprenolol, carteolol, isamoltane, oxprenolol, penbutolol, propranolol, tertatolol ) Elzasonan Ergolines ( e.g., metergoline ) GR - 127935 Isamoltane LY - 393558 Metitepine ( methiothepin ) SB - 216641 SB - 224289 SB - 236057 Yohimbine Unknown / unsorted : Ergolines ( e.g., cabergoline, ergometrine ( ergonovine ), lisuride ) 5 - HT Agonists : CP - 122,288 CP - 135807 CP - 286601 Ergolines ( e.g., bromocriptine, cabergoline, dihydroergotamine, ergotamine, LSD, methysergide ) GR - 46611 L - 694247 L - 772405 mCPP PNU - 109291 PNU - 142633 Serotonin ( 5 - HT ) TGBA01AD Triptans ( e.g., almotriptan, avitriptan, donitriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan ) Tryptamines ( e.g., 5 - BT, 5 - CT, 5 - Et - DMT, 5 - MT, 5 - ( nonyloxy ) tryptamine, DMT ) Antagonists : Alniditan BRL - 15572 Elzasonan Ergolines ( e.g., metergoline ) GR - 127935 Ketanserin LY - 310762 LY - 367642 LY - 393558 LY - 456219 LY - 456220 Metitepine ( methiothepin ) Mianserin Ritanserin Yohimbine Ziprasidone Unknown / unsorted : Acetryptine Ergolines ( e.g., lisuride, lysergol, pergolide ) 5 - HT Agonists : BRL - 54443 Ergolines ( e.g., methysergide ) Serotonin ( 5 - HT ) Triptans ( e.g., eletriptan ) Tryptamines ( e.g., tryptamine ) Antagonists : Metitepine ( methiothepin ) Unknown / unsorted : Ergolines ( e.g., ergometrine ( ergonovine ), lysergol, methylergometrine ( methylergonovine ) 5 - HT Agonists : BRL - 54443 CP - 122,288 Ergolines ( e.g., bromocriptine, lysergol, methylergometrine ( methylergonovine ) methysergide ) Lasmiditan LY - 334370 Serotonin ( 5 - HT ) Triptans ( e.g., eletriptan, naratriptan, sumatriptan ) Tryptamines ( e.g., 5 - MT ) Antagonists : Mianserin Metitepine ( methiothepin ) 5 - HT 5 - HT Agonists : 25H / NB series ( e.g., 25I - NBF, 25I - NBMD, 25I - NBOH, 25I - NBOMe, 25B - NBOMe, 25C - NBOMe, 25TFM - NBOMe, 2CBCB - NBOMe, 25CN - NBOH, 2CBFly - NBOMe ) 2Cs ( e.g., 2C - B, 2C - E, 2C - I, 2C - T - 2, 2C - T - 7, 2C - T - 21 ) 2C - B - FLY 2CB - Ind 5 - Methoxytryptamines ( 5 - MeO - DET, 5 - MeO - DiPT, 5 - MeO - DMT, 5 - MeO - DPT, 5 - MT ) α - Alkyltryptamines ( e.g., 5 - Cl - αMT, 5 - Fl - αMT, 5 - MeO - αET, 5 - MeO - αMT, α - Me - 5 - HT, αET, αMT ) AL - 34662 AL - 37350A Bromo - DragonFLY Dimemebfe DMBMPP DOx ( e.g., DOB, DOC, DOI, DOM ) Efavirenz Ergolines ( e.g., 1P - LSD, ALD - 52, bromocriptine, cabergoline, ergine ( LSA ), ergometrine ( ergonovine ), ergotamine, lisuride, LA - SS - Az, LSB, LSD, LSD - Pip, LSH, LSP, methylergometrine ( methylergonovine ), pergolide ) Flumexadol Jimscaline Lorcaserin MDxx ( e.g., MDA ( tenamfetamine ), MDMA ( midomafetamine ), MDOH, MMDA ) O - 4310 Oxaflozane PHA - 57378 PNU - 22394 PNU - 181731 RH - 34 Phenethylamines ( e.g., lophophine, mescaline ) Piperazines ( e.g., BZP, quipazine, TFMPP ) Serotonin ( 5 - HT ) TCB - 2 TFMFly Tryptamines ( e.g., 5 - BT, 5 - CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine ) Antagonists : 5 - I - R91150 5 - MeO - NBpBrT AC - 90179 Adatanserin Altanserin Antihistamines ( e.g., cyproheptadine, hydroxyzine, ketotifen, perlapine ) AMDA Atypical antipsychotics ( e.g., amperozide, aripiprazole, asenapine, blonanserin, brexpiprazole, carpipramine, clocapramine, clorotepine, clozapine, fluperlapine, gevotroline, iloperidone, lurasidone, melperone, mosapramine, ocaperidone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, zicronapine, ziprasidone, zotepine ) Cinanserin CSP - 2503 Deramciclane Dotarizine Eplivanserin Ergolines ( e.g., amesergide, LY - 53857, LY - 215840, mesulergine, metergoline, methysergide, sergolexole ) Fananserin Flibanserin Glemanserin Irindalone Ketanserin KML - 010 Landipirdine LY - 393558 mCPP Medifoxamine Metitepine ( methiothepin ) MIN - 101 MIN - 117 ( WF - 516 ) Naftidrofuryl Nantenine Nelotanserin Opiranserin ( VVZ - 149 ) Pelanserin Phenoxybenzamine Pimavanserin Pirenperone Pizotifen Pruvanserin Rauwolscine Ritanserin S - 14671 Sarpogrelate Serotonin antagonists and reuptake inhibitors ( e.g., etoperidone, hydroxynefazodone, lubazodone, mepiprazole, nefazodone, triazoledione, trazodone ) SR - 46349B TGBA01AD Teniloxazine Temanogrel Tetracyclic antidepressants ( e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine ) Tricyclic antidepressants ( e.g., amitriptyline ) Typical antipsychotics ( e.g., chlorpromazine, fluphenazine, haloperidol, loxapine, perphenazine, pimozide, pipamperone, prochlorperazine, setoperone, spiperone, spiramide, thioridazine, thiothixene, trifluoperazine ) Volinanserin Xylamidine Yohimbine Unknown / unsorted : Ergolines ( e.g., dihydroergotamine, nicergoline ) 5 - HT Agonists : 4 - Methylaminorex Aminorex Amphetamines ( e.g., chlorphentermine, cloforex, dexfenfluramine, fenfluramine, levofenfluramine, norfenfluramine ) BW - 723C86 DOx ( e.g., DOB, DOC, DOI, DOM ) Ergolines ( e.g., cabergoline, dihydroergocryptine, dihydroergotamine, ergotamine, methylergometrine ( methylergonovine ), methysergide, pergolide ) Lorcaserin MDxx ( e.g., MDA ( tenamfetamine ), MDMA ( midomafetamine ), MDOH, ( MMDA ( drug ) Antagonists : Agomelatine Atypical antipsychotics ( e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, cariprazine, clozapine, N - desalkylquetiapine ( norquetiapine ), N - desmethylclozapine ( norclozapine ), olanzapine, pipamperone, quetiapine, risperidone, ziprasidone ) Cyproheptadine EGIS - 7625 Ergolines ( e.g., amesergide, bromocriptine, lisuride, LY - 53857, LY - 272015, mesulergine ) Ketanserin LY - 393558 mCPP Metadoxine Metitepine ( methiothepin ) Pirenperone Pizotifen Propranolol PRX - 08066 Rauwolscine Ritanserin RS - 127445 Sarpogrelate SB - 200646 SB - 204741 SB - 206553 SB - 215505 SB - 221284 SB - 228357 SDZ SER - 082 Tegaserod Tetracyclic antidepressants ( e.g., amoxapine, mianserin, mirtazapine ) Trazodone Typical antipsychotics ( e.g., chlorpromazine ) TIK - 301 Yohimbine Unknown / unsorted : Ergolines ( e.g., ergometrine ( ergonovine ) ) 5 - HT Agonists : 2Cs ( e.g., 2C - B, 2C - E, 2C - I, 2C - T - 2, 2C - T - 7, 2C - T - 21 ) 5 - Methoxytryptamines ( 5 - MeO - DET, 5 - MeO - DiPT, 5 - MeO - DMT, 5 - MeO - DPT, 5 - MT ) α - Alkyltryptamines ( e.g., 5 - Cl - αMT, 5 - Fl - αMT, 5 - MeO - αET, 5 - MeO - αMT, α - Me - 5 - HT, αET, αMT ) A-372159 AL - 38022A Alstonine CP - 809101 Dimemebfe DOx ( e.g., DOB, DOC, DOI, DOM ) Ergolines ( e.g., ALD - 52, cabergoline, dihydroergotamine, ergine ( LSA ), ergotamine, lisuride, LA - SS - Az, LSB, LSD, LSD - Pip, LSH, LSP, pergolide ) Flumexadol Lorcaserin MDxx ( e.g., MDA ( tenamfetamine ), MDMA ( midomafetamine ), MDOH, MMDA ) MK - 212 Org 12962 Org 37684 Oxaflozane PHA - 57378 Phenethylamines ( e.g., lophophine, mescaline ) Piperazines ( e.g., aripiprazole, BZP, mCPP, quipazine, TFMPP ) PNU - 22394 PNU - 181731 Ro60 - 0175 Ro60 - 0213 Serotonin ( 5 - HT ) Tryptamines ( e.g., 5 - BT, 5 - CT, bufotenin, DET, DiPT, DMT, DPT, psilocin, psilocybin, tryptamine ) Vabicaserin WAY - 629 WAY - 161503 YM - 348 Antagonists : Adatanserin Agomelatine Atypical antipsychotics ( e.g., asenapine, clorotepine, clozapine, fluperlapine, iloperidone, melperone, olanzapine, paliperidone, quetiapine, risperidone, sertindole, ziprasidone, zotepine ) Captodiame CEPC Cinanserin Cyproheptadine Deramciclane Desmetramadol Dotarizine Eltoprazine Ergolines ( e.g., amesergide, bromocriptine, LY - 53857, LY - 215840, mesulergine, metergoline, methysergide, sergolexole ) Etoperidone Fluoxetine FR - 260010 Irindalone Ketanserin Ketotifen Latrepirdine ( dimebolin ) Medifoxamine Metitepine ( methiothepin ) Nefazodone Pirenperone Pizotifen Propranolol Ritanserin RS - 102221 S - 14671 SB - 200646 SB - 206553 SB - 221284 SB - 228357 SB - 242084 SB - 243213 SDZ SER - 082 Tedatioxetine Tetracyclic antidepressants ( e.g., amoxapine, aptazapine, esmirtazapine, maprotiline, mianserin, mirtazapine ) TIK - 301 Tramadol Trazodone Tricyclic antidepressants ( e.g., amitriptyline, nortriptyline ) Typical antipsychotics ( e.g., chlorpromazine, loxapine, pimozide, pipamperone, thioridazine ) Xylamidine Unknown / unsorted : Efavirenz Ergolines ( e.g., ergometrine ( ergonovine ), methylergometrine ( methylergonovine ) ) 5 - HT 5 - HT Agonists : Alcohols ( e.g., butanol, ethanol ( alcohol ), trichloroethanol ) m - CPBG Phenylbiguanide Piperazines ( e.g., BZP, mCPP, quipazine ) RS - 56812 Serotonin ( 5 - HT ) SR - 57227 SR - 57227A Tryptamines ( e.g., 2 - Me - 5 - HT, 5 - CT, bufotenidine ( 5 - HTQ ) ) Volatiles / gases ( e.g., halothane, isoflurane, toluene, trichloroethane ) YM - 31636 Antagonists : Alosetron AS - 8112 Atypical antipsychotics ( e.g., clozapine, olanzapine, quetiapine ) Azasetron Batanopride Bemesetron ( MDL - 72222 ) Bupropion Cilansetron CSP - 2503 Dazopride Dolasetron Galanolactone Granisetron Hydroxybupropion ICS - 205930 Lerisetron Memantine Ondansetron Palonosetron Ramosetron Renzapride Ricasetron Tedatioxetine Tetracyclic antidepressants ( e.g., amoxapine, mianserin, mirtazapine ) Thujone Tropanserin Tropisetron Typical antipsychotics ( e.g., loxapine ) Volatiles / gases ( e.g., nitrous oxide, sevoflurane, xenon ) Vortioxetine Zacopride Zatosetron Unknown / unsorted : LY - 53857 Piperazines ( e.g., naphthylpiperazine ) 5 - HT Agonists : 5 - MT BIMU8 Capeserod Cinitapride Cisapride CJ - 033466 Dazopride Metoclopramide Minesapride Mosapride Prucalopride PRX - 03140 Renzapride RS - 67333 RS - 67506 Serotonin ( 5 - HT ) Tegaserod Velusetrag Zacopride Antagonists : GR - 113808 GR - 125487 L - Lysine Piboserod RS - 39604 RS - 67532 SB - 203186 SB - 204070 5 - HT Agonists : Ergolines ( e.g., 2 - Br - LSD ( BOL - 148 ), ergotamine, LSD ) Serotonin ( 5 - HT ) Tryptamines ( e.g., 5 - CT ) Valerenic Acid Antagonists : Asenapine Latrepirdine ( dimebolin ) Metitepine ( methiothepin ) Ritanserin SB - 699551 Unknown / unsorted : Ergolines ( e.g., metergoline, methysergide ) Piperazines ( e.g., naphthylpiperazine ) 5 - HT Agonists : Ergolines ( e.g., dihydroergocryptine, dihydroergotamine, ergotamine, lisuride, LSD, mesulergine, metergoline, methysergide ) Serotonin ( 5 - HT ) Tryptamines ( e.g., 2 - Me - 5 - HT, 5 - BT, 5 - CT, 5 - MT, Bufotenin, E-6801, E-6837, EMD - 386088, EMDT, LY - 586713, N - Me - 5 - HT, tryptamine ) WAY - 181187 WAY - 208466 Antagonists : ABT - 354 Atypical antipsychotics ( e.g., aripiprazole, asenapine, clorotepine, clozapine, fluperlapine, iloperidone, olanzapine, tiospirone ) AVN - 101 AVN - 211 AVN - 322 AVN - 397 BGC20 - 760 BVT - 5182 BVT - 74316 Cerlapirdine EGIS - 12233 GW - 742457 Idalopirdine Ketanserin Landipirdine Latrepirdine ( dimebolin ) Metitepine ( methiothepin ) MS - 245 PRX - 07034 Ritanserin Ro 04 - 6790 Ro 63 - 0563 SB - 258585 SB - 271046 SB - 357134 SB - 399885 SB - 742457 Tetracyclic antidepressants ( e.g., amoxapine, mianserin ) Tricyclic antidepressants ( e.g., amitriptyline, clomipramine, doxepin, nortriptyline ) Typical antipsychotics ( e.g., chlorpromazine, loxapine ) Unknown / unsorted : Ergolines ( e.g., 2 - Br - LSD ( BOL - 148 ), bromocriptine, lergotrile, pergolide ) Piperazines ( e.g., naphthylpiperazine ) 5 - HT Agonists : 8 - OH - DPAT AS - 19 Bifeprunox E-55888 Ergolines ( e.g., LSD ) LP - 12 LP - 44 RU - 24969 Sarizotan Serotonin ( 5 - HT ) Triptans ( e.g., frovatriptan ) Tryptamines ( e.g., 5 - CT, 5 - MT, bufotenin, N - Me - 5 - HT ) Antagonists : Atypical antipsychotics ( e.g., amisulpride, aripiprazole, asenapine, brexpiprazole, clorotepine, clozapine, fluperlapine, olanzapine, risperidone, sertindole, tiospirone, ziprasidone, zotepine ) Butaclamol DR - 4485 EGIS - 12233 Ergolines ( e.g., 2 - Br - LSD ( BOL - 148 ), amesergide, bromocriptine, cabergoline, dihydroergotamine, ergotamine, LY - 53857, LY - 215840, mesulergine, metergoline, methysergide, sergolexole ) JNJ - 18038683 Ketanserin LY - 215840 Metitepine ( methiothepin ) Ritanserin SB - 258719 SB - 258741 SB - 269970 SB - 656104 SB - 656104A SB - 691673 SLV - 313 SLV - 314 Spiperone SSR - 181507 Tetracyclic antidepressants ( e.g., amoxapine, maprotiline, mianserin, mirtazapine ) Tricyclic antidepressants ( e.g., amitriptyline, clomipramine, imipramine ) Typical antipsychotics ( e.g., acetophenazine, chlorpromazine, chlorprothixene, fluphenazine, loxapine, pimozide ) Vortioxetine Unknown / unsorted : Ergolines ( e.g., lisuride, pergolide ) Piperazines ( e.g., naphthylpiperazine ) See also : Receptor / signaling modulators Adrenergics Dopaminergics Melatonergics Monoamine reuptake inhibitors and releasing agents Monoamine metabolism modulators Monoamine neurotoxins Sigma receptor modulators σ Agonists : 3 - PPP 4 - PPBP 5 - MeO - DMT Alazocine ( SKF - 10047 ) Amantadine ANAVEX2 - 73 Arketamine BD - 737 BD - 1052 Captodiame Citalopram CGRP Cloperastine Cocaine Cutamesine ( SA - 4503 ) Cyclazocine Dehydroepiandrosterone ( DHEA ) ( prasterone ) Dehydroepiandrosterone sulfate ( DHEA - S ) ( prasterone sulfate ) Dextrallorphan Dextromethorphan ( DXM ) Dextrorphan ( DXO ) Dimemorfan Dimethyltryptamine ( DMT ) Ditolylguanidine ( DTG ) Donepezil Eliprodil Escitalopram Fabomotizole ( afobazole ) Fluoxetine Fluvoxamine Ifenprodil Igmesine ( JO - 1784 ) IPAB Ketamine L - 687384 MDMA ( midomafetamine ) Memantine Methamphetamine Methoxetamine Methylphenidate Nepinalone Neuropeptide Y Noscapine OPC - 14523 Opipramol Pentazocine Pentoxyverine ( carbetapentane ) PRE-084 Pregnenolone Pregnenolone sulfate Pridopidine Racemethorphan ( methorphan ) Racemorphan ( morphanol ) UMB - 23 UMB - 82 Antagonists : 3 - PPP AC - 927 BD - 1008 BD - 1031 BD - 1047 BD - 1060 BD - 1063 BD - 1067 BMY - 14802 ( BMS - 181100 ) CM - 156 Dup - 734 E-5842 E-52862 ( S1RA ) Haloperidol LR - 132 LR - 172 MS - 377 NE - 100 NPC - 16377 Panamesine ( EMD - 57455 ) PD - 144418 Pentazocine Progesterone Rimcazole ( BW - 234U ) Sertraline SR - 31742A Allosteric modulators : Phenytoin ; Positive : Methylphenylpiracetam SOMCL - 668 Unknown / unsorted : 3 - Methoxydextrallorphan 3 - MeO - PCP 4C - T - 2 4 - IBP 4 - IPBS 4 - MeO - PCP 5 - MeO - DALT 5 - MeO - DiPT Amitriptyline Azidopamil Chlorpromazine Clemastine Clomipramine Clorgiline D - Deprenyl DiPT DPT Ibogaine Imipramine KCR - 12 - 83.1 Nemonapride Noribogaine RHL - 033 RS - 67,333 RTI - 55 Saffron Safinamide Selegiline Spipethiane Trifluoperazine W - 18 YKP10A σ Agonists : 3 - PPP Arketamine BD - 1047 BD1063 Ditolylguanidine ( DTG ) DKR - 1005 DKR - 1051 Haloperidol Ifenprodil Ketamine MDMA ( midomafetamine ) Methamphetamine OPC - 14523 Opipramol PB - 28 Phencyclidine Siramesine ( Lu 28 - 179 ) UKH - 1114 Antagonists : AC - 927 BD - 1008 BD - 1067 CM - 156 CT - 1812 LR - 172 MIN - 101 Panamesine ( EMD - 57455 ) SAS - 0132 Unknown / unsorted : 3 - Methoxydextrallorphan 3 - MeO - PCE 4 - MeO - PCP 5 - MeO - DALT 5 - MeO - DiPT Clemastine DiPT DPT Ibogaine Nemonapride Nepinalone Noribogaine Pentazocine RS - 67,333 Safinamide TMA UMB - 23 UMB - 82 W - 18 Unsorted Agonists : Berberine Ethylketazocine Fourphit Metaphit Nalbuphine Naluzotan Tapentadol Tenocyclidine Antagonists : AHD1 AZ66 Lamotrigine Naloxone SM - 21 UMB - 100 UMB - 101 UMB - 103 UMB - 116 YZ - 011 YZ - 069 YZ - 185 Allosteric modulators : SKF - 83959 Unknown / unsorted : 18 - Methoxycoronaridine BMY - 13980 Butaclamol Caramiphen Carvotroline Chlorphenamine ( chlorpheniramine ) Chlorpromazine Cinnarizine Cinuperone Clocapramine Dezocine EMD - 59983 Hypericin ( St. John 's wort ) Fluphenazine Gevotroline ( WY - 47384 ) Mepyramine ( pyrilamine ) Molindone Perphenazine Pimozide Proadifen Promethazine Propranolol Quinidine Remoxipride SL 82.0715 SR - 31747A Tiospirone ( BMY - 13859 ) Venlafaxine See also : Receptor / signaling modulators Xenobiotic - sensing receptor modulators CAR Agonists : 6, 7 - Dimethylesculetin Amiodarone Artemisinin Benfuracarb Carbamazepine Carvedilol Chlorpromazine Chrysin CITCO Clotrimazole Cyclophosphamide Cypermethrin DHEA ( prasterone ) Efavirenz Ellagic acid Griseofulvin Methoxychlor Mifepristone Nefazodone Nevirapine Nicardipine Octicizer Permethrin Phenobarbital Phenytoin Pregnanedione ( 5β - dihydroprogesterone ) Reserpine TCPOBOP Telmisartan Tolnaftate Troglitazone Valproic acid Antagonists : 3, 17β - Estradiol 3α - Androstanol 3α - Androstenol 3β - Androstanol 17 - Androstanol AITC Ethinylestradiol Meclizine Nigramide J Okadaic acid PK - 11195 S - 07662 T - 0901317 PXR Agonists : 17α - Hydroxypregnenolone 17α - Hydroxyprogesterone Δ - Androstenedione Δ - Androstenediol Δ - Androstenedione AA - 861 Allopregnanediol Allopregnanedione ( 5α - dihydroprogesterone ) Allopregnanolone ( brexanolone ) Alpha - Lipoic acid Ambrisentan AMI - 193 Amlodipine besylate Antimycotics Artemisinin Aurothioglucose Bile acids Bithionol Bosentan Bumecaine Cafestol Cephaloridine Cephradine Chlorpromazine Ciglitazone Clindamycin Clofenvinfos Chloroxine Clotrimazole Colforsin Corticosterone Cyclophosphamide Cyproterone acetate Demecolcine Dexamethasone DHEA ( prasterone ) DHEA - S ( prasterone sulfate ) Dibunate sodium Diclazuril Dicloxacillin Dimercaprol Dinaline Docetaxel Docusate calcium Dodecylbenzenesulfonic acid Dronabinol Droxidopa Eburnamonine Ecopipam Enzacamene Epothilone B Erythromycin Famprofazone Febantel Felodipine Fenbendazole Fentanyl Flucloxacillin Fluorometholone Griseofulvin Guggulsterone Haloprogin Hetacillin potassium Hyperforin Hypericum perforatum ( St John 's wort ) Indinavir sulfate Lasalocid sodium Levothyroxine Linolenic acid LOE - 908 Loratadine Lovastatin Meclizine Metacycline Methylprednisolone Metyrapone Mevastatin Mifepristone Nafcillin Nicardipine Nicotine Nifedipine Nilvadipine Nisoldipine Norelgestromin Omeprazole Orlistat Oxatomide Paclitaxel Phenobarbital Piperine Plicamycin Prednisolone Pregnanediol Pregnanedione ( 5β - dihydroprogesterone ) Pregnanolone Pregnenolone Pregnenolone 16α - carbonitrile Proadifen Progesterone Quingestrone Reserpine Reverse triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR - 12813 Suberoylanilide Sulfisoxazole Suramin Tacrolimus Tenylidone Terconazole Testosterone isocaproate Tetracycline Thiamylal sodium Thiothixene Thonzonium bromide Tianeptine Troglitazone Troleandomycin Tropanyl 3, 5 - dimethulbenzoate Zafirlukast Zeranol Antagonists : Ketoconazole Sesamin See also Receptor / signaling modulators Nuclear receptor modulators Tricyclics Classes Acridine Anthracene Dibenzazepine Dibenzocycloheptene Dibenzodiazepine Dibenzothiazepine Dibenzothiepin Dibenzoxazepine Dibenzoxepin Phenothiazine Pyridazinobenzoxazine Pyridinobenzodiazepine Thioxanthene Antidepressants ( TCAs and TeCAs ) 7 - OH - Amoxapine Amezepine Amineptine Amitriptyline Amitriptylinoxide Amoxapine Aptazapine Azepindole Azipramine Batelapine Butriptyline Cianopramine Ciclazindol Ciclopramine Cidoxepin Clomipramine Cotriptyline Cyanodothiepin Demexiptiline Depramine ( balipramine ) Desipramine ( desmethylimipramine ) Desmethylclomipramine Desmethyltrimipramine Dibenzepin Dimetacrine Dosulepin ( dothiepin ) Doxepin Enprazepine Esmirtazapine Fantridone Fluotracen Hepzidine Homopipramol Imipramine Imipraminoxide Intriptyline Iprindole Ketipramine Litracen Lofepramine Losindole Loxapine Maprotiline Mariptiline Mazindol Melitracen Metapramine Mezepine Mianserin Mirtazapine Monometacrine Naranol Nitroxazepine Norbutriptyline Nordoxepin Northiaden ( nordosulepin ) Nortriptyline ( noramitriptyline ) Noxiptiline Octriptyline Opipramol Oxaprotiline Pipofezine Pirandamine Propizepine Protriptyline Quinupramine Setiptiline ( teciptiline ) Spiroxepin Tandamine Tampramine Tianeptine Tienopramine Trimipramine Antihistamines Azatadine Clobenzepam Cyproheptadine Dacemazine Deptropine Desloratadine Epinastine Etymemazine Fenethazine Hydroxyethylpromethazine Isopromethazine Isothipendyl Ketotifen Latrepirdine Loratadine Mebhydrolin Mequitazine Methdilazine Olopatadine Oxomemazine Phenindamine Pimethixene Promethazine Propiomazine Rupatadine Thiazinamium Antipsychotics Acetophenazine Alimemazine Amoxapine Asenapine Butaclamol Butaperazine Carfenazine ( carphenazine ) Carpipramine Chlorpromazine Chlorprothixene Ciclindole Citatepine Clocapramine Clomacran Clorotepine Clotiapine Clozapine Cyanothepin Doclothepin Docloxythepin Erizepine Flucindole Flumezapine Fluotracen Flupentixol Fluphenazine Gevotroline Homopipramol Isofloxythepin Levomepromazine / Methotrimeprazine Loxapine Maroxepin Meperathiepin Mesoridazine Metiapine Metitepine Metoxepin Mosapramine Naranol Octomethothepin Olanzapine Oxyclothepin Oxyprothepin Pentiapine Peradithiepin Perathiepin Perazine Perphenazine Periciazine Pinoxepin Piperacetazine Pipotiazine Piquindone Prochlorperazine Promazine Prothipendyl Quetiapine Savoxepin / Cipazoxapine Sulforidazine Tenilapine Thiethylperazine Thiopropazate Thioridazine Thiothixene Tilozepine Traboxopine Trifluoperazine Triflupromazine Trifluthepin Zotepine Zuclopenthixol Anticonvulsants Carbamazepine Dizocilpine Eslicarbazepine Eslicarbazepine acetate Etazepine Licarbazepine Oxcarbazepine Oxitriptyline Rispenzepine Others Adosopine Aminopromazine Atiprosin Beloxepin Benzoctamine Carvedilol Cidoxepin Cyclobenzaprine Damotepine Darenzepine Elanzepine Fluradoline Methylene blue Monatepil Nuvenzepine Oxetorone Perlapine P7C3 Pinadoline Pirenzepine Pirolate Pitrazepin Pizotifen Profenamine Serazapine Siltenzepine Telenzepine Tipindole Tropatepine Zolenzepine Pharmacy and pharmacology portal Medicine portal Retrieved from `` https://en.wikipedia.org/w/index.php?title=Chlorpromazine&oldid=824593637 '' Categories : Antiemetics Chloroarenes Hepatotoxins Phenothiazines Prolactin releasers Sigma receptor ligands Typical antipsychotics World Health Organization essential medicines Hidden categories : CS1 maint : Multiple names : authors list Pages using web citations with no URL Use dmy dates from November 2013 Template : drugs.com link with non-standard subpage ECHA InfoCard ID from Wikidata Drugboxes which contain changes to watched fields Pages using div col with deprecated parameters All articles with unsourced statements Articles with unsourced statements from March 2011 Articles with unsourced statements from February 2017 RTT Talk Contents About Wikipedia تۆرکجه Български Català Čeština Deutsch Ελληνικά Español فارسی Français Հայերեն Italiano עברית Latina Latviešu Magyar Nederlands 日本 語 Norsk ଓଡ଼ିଆ Polski Português Русский Simple English Slovenščina Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska Türkçe Українська 中文 Edit links This page was last edited on 8 February 2018, at 08 : 38. 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Question: phenothiazines such as chlorpromazine were the first type of
Answer: antipsychotic