Heart murmur - wikipedia Heart murmur This article may be too technical for most readers to understand. Please help improve it to make it understandable to non-experts, without removing the technical details. The talk page may contain suggestions. ( April 2014 ) Cardiac murmurs and other cardiac sounds Auscultogram from normal and abnormal heart sounds Classification and external resources Specialty Cardiology ICD - 10 R01 ICD - 9 - CM 785.2 - 785.3 DiseasesDB 29151 MedlinePlus 003266 MeSH D006337 ( edit on Wikidata ) Heart murmurs are heart sounds produced when blood flows across one of the heart valves that are loud enough to be heard with a stethoscope. There are two types of murmurs. A functional murmur or `` physiologic murmur '' is a heart murmur that is primarily due to physiologic conditions outside the heart. Other types of murmurs are due to structural defects in the heart itself. Functional murmurs are benign ( an `` innocent murmur '' ). Murmurs may also be the result of various problems, such as narrowing or leaking of valves, or the presence of abnormal passages through which blood flows in or near the heart. Such murmurs, known as pathologic murmurs, should be evaluated by an expert. Heart murmurs are most frequently categorized by timing, into systolic heart murmurs and diastolic heart murmurs, differing in the part of the heartbeat on which they can be heard. However, continuous murmurs can not be directly placed into either category. Contents 1 Classification 2 Interventions that change murmur sounds 3 Anatomic sources 4 Types and disease associations 5 Cooing dove murmur 6 See also 7 References 8 External links Classification Murmurs can be classified by seven different characteristics : timing, shape, location, radiation, intensity, pitch and quality. Timing refers to whether the murmur is a systolic or diastolic murmur. Shape refers to the intensity over time ; murmurs can be crescendo, decrescendo or crescendo - decrescendo. Crescendo murmurs progressively increase in intensity. Decrescendo murmurs progressively decrease in intensity. With crescendo -- decrescendo murmurs ( diamond or kite - shaped murmurs ), a progressive increase in intensity is followed by a progressive decrease in intensity. Location refers to where the heart murmur is usually heard best. There are four places on the anterior chest wall to listen for heart murmurs ; each of the locations roughly corresponds to a specific part of the heart and should be listened to ( through the stethoscope ) with the patient lying down, face up. The four locations are : Aortic region - the 2nd right intercostal space. Pulmonic region - the 2nd left intercostal spaces. Tricuspid region - the 4th left intercostal space. Mitral region - the 5th left mid-clavicular intercostal space. Additional maneuvers can be performed for additional auscultation : Left lateral decubitus. With the patient sitting upright. With the patient leaning forward and exhaling. Radiation refers to where the sound of the murmur radiates. The rule of thumb is that the sound radiates in the direction of the blood flow. Intensity refers to the loudness of the murmur, and is graded according to the Levine scale, from 1 to 6 : The murmur is only audible on listening carefully for some time. The murmur is faint but immediately audible on placing the stethoscope on the chest. A loud murmur readily audible but with no palpable thrill. A loud murmur with a palpable thrill. A loud murmur with a palpable thrill. The murmur is so loud that it is audible with only the rim of the stethoscope touching the chest. A loud murmur with a palpable thrill. The murmur is audible with the stethoscope not touching the chest but lifted just off it. Pitch may be low, medium or high and is determined by whether it can be auscultated best with the bell or diaphragm of a stethoscope. Quality refers to unusual characteristics of a murmur, such as blowing, harsh, rumbling or musical. A mnemonic to remember what characteristics to look for when listening to murmurs is SCRIPT : Site, Configuration ( shape ), Radiation, Intensity, Pitch and quality, and Timing in the cardiac cycle. The use of two simple mnemonics may help differentiate systolic and diastolic murmurs ; PASS and PAID. Pulmonary and aortic stenoses are systolic while pulmonary and aortic insufficiency ( regurgitation ) are diastolic. Mitral and tricuspid defects are opposite. Interventions that change murmur Sounds Inhalation leads to an increase in intrathoracic negative pressure, which increases the capacity of pulmonary circulation, thereby prolonging ejection time. This will affect the closure of the pulmonary valve. This finding, also called Carvallo 's maneuver, has been found by studies to have a sensitivity of 100 % and a specificity of 80 % to 88 % in detecting murmurs originating in the right heart. specifically positive Carvallo 's sign describes the increase in intensity of a tricuspid regurgitation murmur with inspiration. Abrupt standing Squatting, by increasing afterload and increasing preload. Handgrip maneuver, by increasing afterload Valsalva maneuver. One study found the Valsalva maneuver to have a sensitivity of 65 %, specificity of 96 % in detecting hypertrophic obstructive cardiomyopathy ( HOCM ). Both standing and Valsalva maneuver will decrease venous return and subsequently decrease left ventricular filling, resulting in an increase in the loudness of the murmur of hypertrophic cardiomyopathy, since outflow obstruction is increased by decreasing preload. Alternatively, squatting increases systemic vascular resistance, increasing afterload and helping to hold the obstruction in a more open configuration, decreasing the murmur. Maximum handgrip exercise also results in a decrease in the loudness of the murmur. Post ectopic potentiation Inhaled amyl nitrite is a vasodilator that diminishes systolic murmurs in left - to - right shunts in ventricular septal defects, and reveals right - to left shunts in the setting of a pulmonic stenosis and a ventricular septal defect. Methoxamine Positioning of the patient. That is, putting patients in the left lateral position will allow a murmur in the mitral valve area to be more pronounced. Anatomic sources Systolic Main article : Systolic heart murmur Aortic valve stenosis typically is a crescendo / decrescendo systolic murmur best heard at the right upper sternal border sometimes with radiation to the carotid arteries. In mild aortic stenosis, the crescendo - decrescendo is early peaking whereas in severe aortic stenosis, the crescendo is late - peaking, and the S2 heart sound may be obliterated. Stenosis of Bicuspid aortic valve is similar to the aortic valve stenosis heart murmur, but a systolic ejection click may be heard after S1 in calcified bicuspid aortic valves. Symptoms tend to present between 40 and 70 years of age. Mitral regurgitation typically is a holosystolic ( pansystolic ) murmur heard best at the apex, and may radiate to the axilla or precordium. A systolic click may be heard if there is associated mitral valve prolapse. Valsalva maneuver in mitral regurgitation associated with mitral valve prolapse will decrease left ventricular preload and move the murmur onset closer to S1, and isometric handgrip, which increases left ventricular afterload, will increase murmur intensity. In acute severe mitral regurgitation, a holosystolic ( pansystolic ) murmur may not be heard. Pulmonary valve stenosis typically is a crescendo - decrescendo murmur heard best at the left upper sternal border, associated with a systolic ejection click that increases with inspiration ( due to increased venous return to the right side of the heart ) and sometimes radiates to the left clavicle. Tricuspid valve regurgitation presents as a holosystolic ( pansystolic ) murmur at the left lower sternal border with radiation to the left upper sternal border. Prominent v and c waves may be seen in the JVP ( jugular venous pressure ). The murmur will increase with inspiration. Hypertrophic obstructive cardiomyopathy ( or hypertrophic subaortic stenosis ) will be a systolic crescendo - decrescendo murmur best heard at the left lower sternal border. Valsalva maneuver will increase the intensity of the murmur, as will changing positions from squatting to standing. Atrial septal defect will present with a systolic crescendo - decrescendo murmur best heard at the left upper sternal border due to increased volume going through the pulmonary valve, and is associated with a fixed, split S2 and a right ventricular heave. Ventricular septal defect ( VSD ) will present as a holosystolic ( pansystolic ) murmur at the left lower sternal border, associated with a palpable thrill, and increases with isometric handgrip. A right to left shunt ( Eisenmenger syndrome ) may develop with uncorrected VSDs due to worsening pulmonary hypertension, which will increase the murmur intensity and be associated with cyanosis. Flow murmur may be heard at the right upper sternal border in certain conditions, such as anemia, hyperthyroidism, fever, and pregnancy. Diastolic Main article : Diastolic heart murmur Aortic valve regurgitation will present as a diastolic decrescendo murmur heard at the left lower sternal border or right lower sternal border ( when associated with a dilated aorta ). This may be associated with bounding carotid and peripheral pulses ( Corrigan 's pulse, Watson 's water hammer pulse ), and a widened pulse pressure. Mitral stenosis typically presents as a diastolic low - pitched decrescendo murmur best heard at the cardiac apex in the left lateral decubitus position. It may be associated with an opening snap. Increasing severity will shorten the time between S2 ( A2 ) and the opening snap. ( i.e. In severe MS the opening snap will occur earlier after A2 ) Tricuspid valve stenosis presents as a diastolic decrescendo murmur at the left lower sternal border, and signs of right heart failure may be seen on exam. Pulmonary valve regurgitation presents as a diastolic decrescendo murmur at the left lower sternal border. A palpable S2 in the second left intercostal space correlates with pulmonary hypertension due to mitral stenosis. Continuous and Combined Systolic / Diastolic Patent ductus arteriosus may present as a continuous murmur radiating to the back. Severe coarctation of the aorta can present with a continuous murmur : a systolic component at the left infraclavicular region and the back due to the stenosis, and a diastolic component over the chest wall due to blood flow through collateral vessels. Acute severe aortic regurgitation is associated with a three phase murmur, specifically a midsystolic murmur followed by S2, followed by a parasternal early diastolic and mid-diastolic murmur ( Austin Flint murmur ). Although the exact cause of an Austin Flint murmur is unknown, it is hypothesized that the mechanism of murmur is from the severe aortic regurgitation jet vibrating the anterior mitral valve leaflet, colliding with the mitral inflow during diastole, with increased mitral inflow velocity from the narrowed mitral valve orifice leading to the jet impinging on the myocardial wall. Another uncommon cause of a continuous murmur is a ruptured sinus of valsalva. Usually the murmur is well heard in the aortic area and along the left sternal border. Types and disease associations Continuous machinery murmur, at the left upper sternal border Classic for a patent ductus arteriosus, and in serious cases associated with poor feeding, failure to thrive and respiratory distress. Other examination findings may include widened pulse pressures and bounding pulses. Systolic murmur loudest below the left scapula Classic for a coarctation of the aorta which is often seen in Turner 's Syndrome, ( gonadal dysgenesis ), an X-linked disorder with a part missing of the X-chromosome. Other findings of this murmur is radio - femoral delay, and different blood pressures in the upper and lower extremities. Harsh holosystolic ( pansystolic ) murmur at the left lower sternal border Classic for a ventricular septal defect. It is in these children that the delayed - onset cyanotic heart disease occurs known as Eisenmenger syndrome, which is a reversal of the left - to - right heart shunt as the right ventricle hypertrophies, causing a right - to - left shunt and resulting cyanosis. Widely split fixed S and systolic ejection murmur at the left upper sternal border Classically due to a patent foramen ovale or atrial septal defect, which is lack of closure of the foramen ovale. This produces a left - to - right shunt initially, thus does not produce cyanosis, but causes pulmonary hypertension. Longstanding uncorrected atrial septal defects can also result in Eisenmenger 's syndrome with resultant cyanosis. Cooing dove murmur The cooing dove murmur is a cardiac murmur with a musical quality ( high pitched - hence the name ) and is associated with aortic valve regurgitation ( or mitral regurgitation before rupture of chordae ). It is a diastolic murmur which can be heard over the mid-precordium. ( 1 ) See also Benign paediatric heart murmur George Alexander Gibson discoverer of the Gibson murmur. Precordial examination References Jump up ^ `` heart murmur '' at Dorland 's Medical Dictionary Jump up ^ `` continuous murmur '' at Dorland 's Medical Dictionary Jump up ^ `` Heart murmur : characteristics ''. LifeHugger. Retrieved 2009 - 09 - 23. Jump up ^ Orient JM. `` Chapter 17 : The Heart ''. Sapira 's Art & Science of Bedside Diagnosis ( 4th ed. ). Philadelphia : Wolters Kluwers Health. p. 339. ISBN 978 - 1 - 60547 - 411 - 3. Jump up ^ Freeman AR, Levine SA ( 1933 ). `` Clinical significance of systolic murmurs : Study of 1000 consecutive `` noncardiac '' cases. ``. Ann Intern Med. 6 : 1371 -- 1379. doi : 10.7326 / 0003 - 4819 - 6 - 11 - 1371. Jump up ^ `` Medline Plus Medical Dictionary, definition of `` cardiac thrill '' ``. Jump up ^ https://www.youtube.com/watch?v=4euNGIguluk Mnemonic tutorial video for cardiac murmurs ^ Jump up to : Lembo N, Dell'Italia L, Crawford M, O'Rourke R ( 1988 ). `` Bedside diagnosis of systolic murmurs ''. N Engl J Med. 318 ( 24 ) : 1572 -- 8. PMID 2897627. doi : 10.1056 / NEJM198806163182404. Jump up ^ Maisel A, Atwood J, Goldberger A ( 1984 ). `` Hepatojugular reflux : useful in the bedside diagnosis of tricuspid regurgitation ''. Ann Intern Med. 101 ( 6 ) : 781 -- 2. PMID 6497192. doi : 10.7326 / 0003 - 4819 - 101 - 6 - 781. Jump up ^ Harrison 's Internal Medicine 17th, chapter 5, `` Disorders of the cardiovascular system, '' question 32, self assessment and board review Jump up ^ Harrison 's Internal Medicine 17th, chapter 5, `` Disorders of the cardiovascular system, '' question 86 - 87, self assessment and board review Jump up ^ Cumming, Gordon R. ( 1963 ). `` AMYL NITRITE INDUCED CHANGES IN CARDIAC SHUNTS ''. Br Heart J. 25 ( 4 ) : 521 -- 531. PMC 1018027. PMID 14047161. Jump up ^ John Oshinski ; Robert Franch, MD ; Murray Baron, MD ; Roderic Pettigrew, MD ( 1998 ). `` Images in Cardiovascular Medicine Austin Flint Murmur ''. Circulation. 98 ( 24 ) : 2782 -- 2783. PMID 9851968. doi : 10.1161 / 01. cir. 98.24. 2782. Jump up ^ `` Blaufuss Multimedia - Heart Sounds and Cardiac Arrhythmias ''. Medical Multimedia Laboratories. Retrieved 2 August 2013. Jump up ^ Topi, Bernard ; John ( September 2012 ). `` An uncommon cause of a continuous murmur. ''. Experimental and clinical cardiology. 17 ( 3 ) : 148 -- 149. PMC 3628432. PMID 23620707. External links Information on heart murmurs in children from Seattle Children 's Heart Center Heart Murmurs in Pediatric Patients Lehrer, Steven. Understanding Pediatric Heart Sounds. Elsevier 2002. Hanifin, Christopher. Heart Sounds : A Cardiac Auscultation Primer. CreateSpace, 2010 Texas Heart Institute Scroll down to listen to heart murmurs. The Auscultation Assistant Provides recordings of heart murmurs. Heart murmurs in children information for parents. Patient and simulated holosystolic murmurs with audio, text, phonocardiograms and cardiac animations. Symptoms and signs relating to the cardiovascular system ( R00 -- R03, 785 ) Chest pain Referred pain Angina Aerophagia Auscultation Heart sounds Split S2 S3 S4 Gallop rhythm Heart murmur Systolic Diastolic Continuous Pericardial friction rub Heart click Bruit carotid Pulse Tachycardia Bradycardia Pulsus tardus et parvus Pulsus paradoxus doubled Pulsus bisferiens Dicrotic pulse Pulsus bigeminus Pulsus alternans Pulse deficit Vascular disease Gangrene Other Palpitations Apex beat Cœur en sabot Jugular venous pressure Cannon A waves Hyperaemia Shock Cardiogenic Hypovolemic Distributive Septic Neurogenic Eponymous medical signs for circulatory system Heart disease Heart murmur Systolic heart murmur : Benign paediatric heart murmur ( Still 's murmur ) Diastolic heart murmur : Pulmonic regurgitation ( Graham Steell murmur ) Aortic insufficiency ( Austin Flint murmur ) Carey Coombs murmur Mitral regurgitation ( Presystolic murmur ) Aortic insufficiency Watson 's water hammer pulse / Corrigan pulse De Musset 's sign Duroziez 's sign Müller 's sign Quincke 's sign Austin Flint murmur Mayne 's sign Other endocardium endocarditis : Roth 's spot Janeway lesion / Osler 's node Bracht - Wachter bodies Pericardium Cardiac tamponade / Pericardial effusion : Beck 's triad Ewart 's sign Other rheumatic fever : Anitschkow cell Aschoff body EKG ( Osborn wave ) angina pectoris ( Levine 's sign ) Gallavardin phenomenon Vascular disease Arterial aortic aneurysm ( Cardarelli 's sign, Oliver 's sign ) pulmonary embolism ( McConnell 's sign ) radial artery sufficiency ( Allen 's test ) pseudohypertension ( Osler 's sign ) thrombus ( Lines of Zahn ) Adson 's sign arteriovenous fistula ( Nicoladoni sign ) Venous Friedreich 's sign Caput medusae Kussmaul 's sign DVT Bancroft 's sign Homans sign Lisker 's sign Louvel 's sign Lowenberg 's sign Peabody 's sign Pratt 's sign Rose 's sign Trendelenburg test superior vena cava syndrome ( Pemberton 's sign ) Retrieved from `` https://en.wikipedia.org/w/index.php?title=Heart_murmur&oldid=789170009 '' Categories : Heart murmurs Turbulence Hidden categories : Wikipedia articles that are too technical from April 2014 All articles that are too technical Articles needing expert attention from April 2014 All articles needing expert attention Talk Contents About Wikipedia Català Deutsch Eesti Español فارسی Français 한국어 Italiano עברית Lumbaart Nederlands 日本 語 Polski Português Shqip Svenska தமிழ் ไทย Türkçe 中文 Edit links This page was last edited on 5 July 2017, at 19 : 55. 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Question: when is the murmur heard in the cardiac cycle
Answer: systolic