Frank -- Starling law - wikipedia Frank -- Starling law Cardiac function curve In diagrams illustrating the Frank -- Starling law of the heart, the y - axis often describes the stroke volume, stroke work, or cardiac output. The x-axis often describes end - diastolic volume, right atrial pressure, or pulmonary capillary wedge pressure. The three curves illustrate that shifts along the same line indicate a change in preload, while shifts from one line to another indicate a change in afterload or contractility. A blood volume increase would cause a shift along the line to the right, which increases left ventricular end diastolic volume ( x axis ), and therefore also increases stroke volume ( y axis ). The Frank -- Starling law of the heart ( also known as Starling 's law and the Frank -- Starling mechanism ) represents the relationship between stroke volume and end diastolic volume. The law states that the stroke volume of the heart increases in response to an increase in the volume of blood in the ventricles, before contraction ( the end diastolic volume ), when all other factors remain constant. As a larger volume of blood flows into the ventricle, the blood stretches the cardiac muscle fibers, leading to an increase in the force of contraction. The Frank - Starling mechanism allows the cardiac output to be synchronized with the venous return, arterial blood supply and humoral length, without depending upon external regulation to make alterations. The physiological importance of the mechanism lies mainly in maintaining left and right ventricular output equality. Contents 1 Physiology 2 Clinical examples 2.1 Premature ventricular contraction 2.2 Diastolic dysfunction -- heart failure 3 History 4 See also 5 References 6 External links Physiology The Frank - Starling mechanism occurs as the result of the length - tension relationship observed in skeletal muscles. As a muscle fiber is stretched, active tension is created by altering the overlap of thick and thin filaments. The greatest isometric active tension is developed when a muscle is at its optimal length. In most relaxed skeletal muscle fibers, passive elastic properties maintain the muscle fibers length near optimal. In contrast, the normal point of cardiac muscle cells, in a resting individual, is lower than the optimal length for contraction. In the human heart, maximal force is generated with an initial sarcomere length of 2.2 micrometers, a length which is rarely exceeded in a normal heart. Initial lengths larger or smaller than this optimal value will decrease the force the muscle can achieve. For larger sarcomere lengths, this is the result of less overlap of the thin and thick filaments ; for smaller sarcomere lengths, the cause is the decreased sensitivity for calcium by the myofilaments. An increase in filling of the ventricle increases the load experienced by each cardiac muscle fiber, stretching the fibers toward their optimal length. The stretching of the muscle fibers augments cardiac muscle contraction by increasing the calcium sensitivity of the myofibrils, causing a greater number of actin - myosin cross-bridges to form within the muscle fibers. Specifically, the sensitivity of troponin for binding Ca increases and there is an increased release of Ca from the sarcoplasmic reticulum. In addition, there is a decrease in the spacing between thick and thin filaments, when a cardiac muscle fiber is stretched, allowing an increased number of cross-bridges to form. The force that any single cardiac muscle fiber generates is proportional to the initial sarcomere length, and the stretch on the individual fibers is related to the end - diastolic volume of the left and right ventricles. Due to the intrinsic property of myocardium that is responsible for the Frank - Starling mechanism, the heart can automatically accommodate an increase in venous return, at any heart rate. The mechanism is of functional importance because it serves to adapt left ventricular output to right ventricular output. If this mechanism did not exist and the right and left cardiac outputs were not equivalent, blood would accumulate throughout circulation. Clinical examples Premature ventricular contraction Premature ventricular contraction causes early emptying of the left ventricle ( LV ) into the aorta. Since the next ventricular contraction occurs at its regular time, the filling time for the LV increases, causing an increased LV end - diastolic volume. Due to the Frank -- Starling mechanism, the next ventricular contraction is more forceful, leading to the ejection of the larger than normal volume of blood, and bringing the LV end - systolic volume back to baseline. Diastolic dysfunction -- heart failure Diastolic dysfunction is associated with a reduced compliance, or increased stiffness, of the ventricle wall. This reduced compliance results in an inadequate filling of the ventricle and a decrease in the end - diastolic volume. The decreased end - diastolic volume then leads to a reduction in stroke volume because of the Frank - Starling mechanism. History The Frank -- Starling law is named after the two physiologists, Otto Frank and Ernest Henry Starling. However, neither Frank nor Starling was the first to describe the relationship between the end - diastolic volume and the regulation of cardiac output. The first formulation of the law was theorized by the Italian physiologist Dario Maestrini, who on December 13, 1914, started the first of 19 experiments that led him to formulate the `` legge del cuore ''. Otto Frank 's contributions are derived from his 1895 experiments on frog hearts. In order to relate the work of the heart to skeletal muscle mechanics, Frank observed changes in diastolic pressure with varying volumes of the frog ventricle. His data was analyzed on a pressure - volume diagram, which resulted in his description of peak isovolumic pressure and its affects on ventricular volume. Starling experimented on intact mammalian hearts, such as from dogs, to understand why variations in arterial pressure, heart rate, and temperature do not affect the relatively constant cardiac output. More than 30 years before the development of sliding filament model of muscle contraction and the understanding of the relationship between active tension and sarcomere length, Starling hypothesized in 1914, `` the mechanical energy set free in the passage from the resting to the active state is a function of the length of the fiber. '' Starling used a volume - pressure diagram to construct a length - tension diagram from his data. Starling 's data and associated diagrams, provided evidence that the length of the muscle fibers, and resulting tension, altered the systolic pressure. See also Starling equation References ^ Jump up to : Widmaier, E.P., Hershel, R., & Strang, K.T. ( 2016 ). Vander 's Human Physiology : The Mechanisms of Body Function ( 14th ed. ). New York, NY : McGraw - Hill Education. ISBN 978 - 1 - 259 - 29409 - 9 Jump up ^ Costanzo, Linda S. ( 2007 ). Physiology. Hagerstwon, MD : Lippincott Williams & Wilkins. p. 81. ISBN 0 - 7817 - 7311 - 3. ^ Jump up to : R., Jacob, ; B., Dierberger, ; G., Kissling, ( 1992 - 11 - 01 ). `` Functional significance of the Frank - Starling mechanism under physiological and pathophysiological conditions ''. European Heart Journal. 13 ( suppl_E ). doi : 10.1093 / eurheartj / 13. suppl_E. 7. ISSN 0195 - 668X. ^ Jump up to : Katz, Arnold M. ( 2002 - 12 - 03 ). `` Ernest Henry Starling, His Predecessors, and the `` Law of the Heart '' ``. Circulation. 106 ( 23 ) : 2986 -- 2992. doi : 10.1161 / 01. CIR. 0000040594.96123. 55. ISSN 0009 - 7322. PMID 12460884. Jump up ^ Klabunde, Richard E. `` Cardiovascular Physiology Concepts ''. Lippincott Williams & Wilkins, 2011, p. 74. Jump up ^ Moss, Richard L. ; Fitzsimons, Daniel P. ( 2002 - 01 - 11 ). `` Frank - Starling Relationship ''. Circulation Research. 90 ( 1 ) : 11 -- 13. ISSN 0009 - 7330. PMID 11786511. Jump up ^ Spadolini, Igino ( 1946 ). UTET, eds. Trattato di Fisiologia,. 2. Torino. CS1 maint : Uses editors parameter ( link ) Jump up ^ Berne, Robert M. ( 2004 ). Ambrosiana, eds. Fisiologia. Milano. CS1 maint : Uses editors parameter ( link ) Jump up ^ `` www.ancecardio.it '' ( PDF ) ( in Italian ). pp. 29 -- 31. Archived from the original ( PDF ) on 2013 - 11 - 09. Retrieved 6 August 2010. Jump up ^ MAESTRINI, D. ( February 1951 ). `` ( Genesis of the so - called insufficient contractions of the heart in decompensation. ) ''. Policlinico Prat. 58 ( 9 ) : 257 -- 68. PMID 14833944. Jump up ^ MAESTRINI, D. ( July 1951 ). `` ( The importance of the altered organic exchange ( fatigue ), of the structure and colloidal state of the fiber, for the genesis of the so - called small, insufficient contractions of the heart in failure. ) ''. Policlinico Prat. 58 ( 30 ) : 933 -- 45. PMID 14864102. Jump up ^ MAESTRINI, D. ( November 1951 ). `` ( The law of the heart in biology and clinical medicine. ) ''. Minerva Med. 42 ( 80 ) : 857 -- 64. PMID 14919226. Jump up ^ MAESTRINI, D. ( June 1952 ). `` ( A new theory of cardiac decompensation. ) ''. Policlinico Prat. 59 ( 24 ) : 797 -- 814. PMID 14957592. Jump up ^ MAESTRINI, D. `` ( Not Available. ) ''. Gazz Sanit. 18 ( 5 ) : 162 -- 4. PMID 18859625. Jump up ^ PENNACCHIO, L. ; D. MAESTRINI ( September 1952 ). `` ( Comment on a new theory of cardiac insufficiency. ) ''. Policlinico Prat. 59 ( 37 ) : 1223 -- 4. PMID 13026471. Jump up ^ MAESTRINI, D. ( January 1958 ). `` ( The law of the heart from its discovery to the present time. ) ''. Minerva Med. 49 ( 3 - 4 ) : Varia, 28 -- 36. PMID 13516733. Jump up ^ MAESTRINI, D. ( December 1958 ). `` ( Variations of cardiac volume dynamics in clinical practice, examined in the light of the law of the heart. ) ''. Minerva Cardioangiol. 6 ( 12 ) : 657 -- 67. PMID 13643787. Jump up ^ MAESTRINI, D. ( February 1959 ). `` ( S. Baglioni and the law of the heart. ) ''. Policlinico Prat. 66 ( 7 ) : 224 -- 30. PMID 13645276. Jump up ^ MAESTRINI, D. ( October 1959 ). `` ( On cardiac dynamics in the phase preceding right hypertrophy and on its electrocardiographic aspect in man. ) ''. Policlinico Prat. 66 : 1409 -- 13. PMID 13853750. Jump up ^ Boron, Walter F. ; Boulpaep, Emile L. ( 2012 - 01 - 13 ). Medical Physiology, 2e Updated Edition E-Book : with STUDENT CONSULT Online Access. Elsevier Health Sciences. ISBN 1455711810. External links `` New Concepts in the Control of Muscle Contraction '' by Gerry A Smith PhD ( Cantab ) Physiology of the cardiovascular system Heart Cardiac output Cardiac cycle Cardiac output Heart rate Stroke volume Stroke volume End - diastolic volume End - systolic volume Afterload Preload Frank -- Starling law Cardiac function curve Venous return curve Wiggers diagram Pressure volume diagram Ultrasound Fractional shortening = ( End - diastolic dimension End - systolic dimension ) / End - diastolic dimension Aortic valve area calculation Ejection fraction Cardiac index Heart rate Cardiac pacemaker Chronotropic ( Heart rate ) Dromotropic ( Conduction velocity ) Inotropic ( Contractility ) Bathmotropic ( Excitability ) Lusitropic ( Relaxation ) Conduction Conduction system Cardiac electrophysiology Action potential cardiac atrial ventricular Effective refractory period Pacemaker potential Electrocardiography P wave PR interval QRS complex QT interval ST segment T wave U wave Hexaxial reference system Chamber pressure Central venous Right atrial ventricular pulmonary artery wedge Left atrial ventricular Aortic Other Ventricular remodeling Vascular system / Hemodynamics Blood flow Compliance Vascular resistance Pulse Perfusion Blood pressure Pulse pressure Systolic Diastolic Mean arterial pressure Jugular venous pressure Portal venous pressure Regulation of BP Baroreflex Kinin -- kallikrein system Renin -- angiotensin system Vasoconstrictors Vasodilators Autoregulation Myogenic mechanism Tubuloglomerular feedback Cerebral autoregulation Paraganglia Aortic body Carotid body Glomus cell Retrieved from `` https://en.wikipedia.org/w/index.php?title=Frank -- Starling_law&oldid = 825697590 '' Categories : Cardiovascular physiology Hidden categories : CS1 maint : Uses editors parameter CS1 Italian - language sources ( it ) All articles with unsourced statements Articles with unsourced statements from May 2017 Talk Contents About Wikipedia Deutsch Eesti Español Français Italiano עברית Nederlands 日本 語 Norsk Polski Português Svenska Українська 中文 6 more Edit links This page was last edited on 14 February 2018, at 21 : 42. 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Question: starlings law of the heart holds that the
Answer: stroke volume of the heart increases in response to an increase in the volume of blood in the ventricles, before contraction (the end diastolic volume), when all other factors remain constant.