Neurotransmitter - wikipedia Neurotransmitter For an introduction to concepts and terminology used in this article, see Chemical synapse. Structure of a typical chemical synapse Postsynaptic density Voltage - gated Ca channel Synaptic vesicle Neurotransmitter transporter Receptor Neurotransmitter Axon terminal Synaptic cleft Dendrite Neurotransmitters are endogenous chemicals that enable neurotransmission. It is a type of chemical messenger which transmits signals across a chemical synapse, such as a neuromuscular junction, from one neuron ( nerve cell ) to another `` target '' neuron, muscle cell, or gland cell. Neurotransmitters are released from synaptic vesicles in synapses into the synaptic cleft, where they are received by neurotransmitter receptors on the target cells. Many neurotransmitters are synthesized from simple and plentiful precursors such as amino acids, which are readily available from the diet and only require a small number of biosynthetic steps for conversion. Neurotransmitters play a major role in shaping everyday life and functions. Their exact numbers are unknown, but more than 200 chemical messengers have been uniquely identified. Contents 1 Mechanism 2 Discovery 3 Identification 4 Types 4.1 List of neurotransmitters, peptides, and gaseous signaling molecules 5 Actions 5.1 Excitatory and inhibitory 5.2 Examples of important neurotransmitter actions 6 Brain neurotransmitter systems 7 Drug effects 7.1 Agonists 7.2 Antagonists 7.2. 1 Drug antagonists 7.3 Precursors 7.3. 1 Catecholamine and trace amine precursors 7.3. 2 Serotonin precursors 8 Diseases and disorders 9 Neurotransmitter imbalance 10 Elimination of neurotransmitters 11 See also 12 Notes 13 References 14 External links Mechanism Neurotransmitters are stored in a synapse in synaptic vesicles, clustered beneath the membrane in the axon terminal located at the presynaptic side of the synapse. Neurotransmitters are released into and diffused across the synaptic cleft, where they bind to specific receptors in the membrane on the postsynaptic side of the synapse. Most neurotransmitters are about the size of a single amino acid, however, some neurotransmitters may be the size of larger proteins or peptides. A released neurotransmitter is typically available in the synaptic cleft for a short time before it is metabolized by enzymes, pulled back into the presynaptic neuron through reuptake, or bound to a postsynaptic receptor. Nevertheless, short - term exposure of the receptor to a neurotransmitter is typically sufficient for causing a postsynaptic response by way of synaptic transmission. In response to a threshold action potential or graded electrical potential, a neurotransmitter is released at the presynaptic terminal. Low level `` baseline '' release also occurs without electrical stimulation. The released neurotransmitter may then move across the synapse to be detected by and bind with receptors in the postsynaptic neuron. Binding of neurotransmitters may influence the postsynaptic neuron in either an inhibitory or excitatory way. This neuron may be connected to many more neurons, and if the total of excitatory influences are greater than those of inhibitory influences, the neuron will also `` fire ''. Ultimately it will create a new action potential at its axon hillock to release neurotransmitters and pass on the information to yet another neighboring neuron. Discovery Until the early 20th century, scientists assumed that the majority of synaptic communication in the brain was electrical. However, through the careful histological examinations by Ramón y Cajal ( 1852 -- 1934 ), a 20 to 40 nm gap between neurons, known today as the synaptic cleft, was discovered. The presence of such a gap suggested communication via chemical messengers traversing the synaptic cleft, and in 1921 German pharmacologist Otto Loewi ( 1873 -- 1961 ) confirmed that neurons can communicate by releasing chemicals. Through a series of experiments involving the vagus nerves of frogs, Loewi was able to manually slow the heart rate of frogs by controlling the amount of saline solution present around the vagus nerve. Upon completion of this experiment, Loewi asserted that sympathetic regulation of cardiac function can be mediated through changes in chemical concentrations. Furthermore, Otto Loewi is credited with discovering acetylcholine ( ACh ) -- the first known neurotransmitter. Some neurons do, however, communicate via electrical synapses through the use of gap junctions, which allow specific ions to pass directly from one cell to another. Identification There are four main criteria for identifying neurotransmitters : The chemical must be synthesized in the neuron or otherwise be present in it. When the neuron is active, the chemical must be released and produce a response in some target. The same response must be obtained when the chemical is experimentally placed on the target. A mechanism must exist for removing the chemical from its site of activation after its work is done. However, given advances in pharmacology, genetics, and chemical neuroanatomy, the term `` neurotransmitter '' can be applied to chemicals that : Carry messages between neurons via influence on the postsynaptic membrane. Have little or no effect on membrane voltage, but have a common carrying function such as changing the structure of the synapse. Communicate by sending reverse - direction messages that affect the release or reuptake of transmitters. The anatomical localization of neurotransmitters is typically determined using immunocytochemical techniques, which identify the location of either the transmitter substances themselves, or of the enzymes that are involved in their synthesis. Immunocytochemical techniques have also revealed that many transmitters, particularly the neuropeptides, are co-localized, that is, one neuron may release more than one transmitter from its synaptic terminal. Various techniques and experiments such as staining, stimulating, and collecting can be used to identify neurotransmitters throughout the central nervous system. Types There are many different ways to classify neurotransmitters. Dividing them into amino acids, peptides, and monoamines is sufficient for some classification purposes. Major neurotransmitters : Amino acids : glutamate, aspartate, D - serine, γ - aminobutyric acid ( GABA ), glycine Gasotransmitters : nitric oxide ( NO ), carbon monoxide ( CO ), hydrogen sulfide ( H S ) Monoamines : dopamine ( DA ), norepinephrine ( noradrenaline ; NE, NA ), epinephrine ( adrenaline ), histamine, serotonin ( SER, 5 - HT ) Trace amines : phenethylamine, N - methylphenethylamine, tyramine, 3 - iodothyronamine, octopamine, tryptamine, etc. Peptides : somatostatin, substance P, cocaine and amphetamine regulated transcript, opioid peptides Purines : adenosine triphosphate ( ATP ), adenosine Others : acetylcholine ( ACh ), anandamide, etc. In addition, over 50 neuroactive peptides have been found, and new ones are discovered regularly. Many of these are `` co-released '' along with a small - molecule transmitter. Nevertheless, in some cases a peptide is the primary transmitter at a synapse. β - endorphin is a relatively well - known example of a peptide neurotransmitter because it engages in highly specific interactions with opioid receptors in the central nervous system. Single ions ( such as synaptically released zinc ) are also considered neurotransmitters by some, as well as some gaseous molecules such as nitric oxide ( NO ), carbon monoxide ( CO ), and hydrogen sulfide ( H S ). The gases are produced in the neural cytoplasm and are immediately diffused through the cell membrane into the extracellular fluid and into nearby cells to stimulate production of second messengers. Soluble gas neurotransmitters are difficult to study, as they act rapidly and are immediately broken down, existing for only a few seconds. The most prevalent transmitter is glutamate, which is excitatory at well over 90 % of the synapses in the human brain. The next most prevalent is Gamma - Aminobutyric Acid, or GABA, which is inhibitory at more than 90 % of the synapses that do not use glutamate. Although other transmitters are used in fewer synapses, they may be very important functionally : the great majority of psychoactive drugs exert their effects by altering the actions of some neurotransmitter systems, often acting through transmitters other than glutamate or GABA. Addictive drugs such as cocaine and amphetamines exert their effects primarily on the dopamine system. The addictive opiate drugs exert their effects primarily as functional analogs of opioid peptides, which, in turn, regulate dopamine levels. List of neurotransmitters, peptides, and gaseous signaling molecules This list is incomplete ; you can help by expanding it. Category Name Abbreviation Metabotropic Ionotropic Small : Amino acids ( Arg ) Arginine α - Adrenergic receptors, imidazoline receptors NMDA receptors Small : Amino acids Asparagine Asp -- NMDA receptors Small : Amino acids Glutamate Glu Metabotropic glutamate receptors NMDA receptors, kainate receptors, AMPARs Small : Amino acids Gamma - aminobutyric acid GABA GABA receptors GABA receptors, GABA - ρ receptors Small : Amino acids Glycine Gly -- NMDA receptors, glycine receptors Small : Amino acids D - serine Ser -- NMDA receptors Small : Acetylcholine Acetylcholine Ach Muscarinic acetylcholine receptors Nicotinic acetylcholine receptors Small : Monoamine ( Phe / Tyr ) Dopamine DA Dopamine receptors, trace amine - associated receptor 1 -- Small : Monoamine ( Phe / Tyr ) Norepinephrine ( noradrenaline ) NE, NAd Adrenergic receptors -- Small : Monoamine ( Phe / Tyr ) Epinephrine ( adrenaline ) Epi, Ad Adrenergic receptors -- Small : Monoamine ( Trp ) Serotonin ( 5 - hydroxytryptamine ) 5 - HT Serotonin receptors ( all except 5 - HT ) 5 - HT Small : Monoamine ( His ) Histamine Histamine receptors -- Small : Trace amine ( Phe ) Phenethylamine PEA Human trace amine - associated receptors : hTAAR1, hTAAR2 -- Small : Trace amine ( Phe ) N - methylphenethylamine NMPEA hTAAR1 -- Small : Trace amine ( Phe / Tyr ) Tyramine TYR hTAAR1, hTAAR2 -- Small : Trace amine ( Phe / Tyr ) Octopamine Oct hTAAR1 -- Small : Trace amine ( Phe / Tyr ) Synephrine Syn hTAAR1 -- Small : Trace amine ( Trp ) Tryptamine hTAAR1, various serotonin receptors -- Small : Trace amine ( Trp ) N - methyltryptamine NMT hTAAR1, various serotonin receptors -- Lipid Anandamide AEA Cannabinoid receptors -- Lipid 2 - Arachidonoylglycerol 2 - AG Cannabinoid receptors -- Lipid 2 - Arachidonyl glyceryl ether 2 - AGE Cannabinoid receptors -- Lipid N - Arachidonoyl dopamine NADA Cannabinoid receptors TRPV1 Lipid Virodhamine Cannabinoid receptors -- Small : Purine Adenosine Ado Adenosine receptors -- Small : Purine Adenosine triphosphate ATP P2Y receptors P2X receptors PP : Bradykinins Bradykinin B1, B2 -- PP : Corticotropin - releasing factors Corticotropin - releasing hormone CRH CRHR1 -- PP : Corticotropin - releasing factors Urocortin CRHR1 -- PP : Galanins Galanin GALR1, GALR2, GALR3 -- PP : Galanins Galanin - like peptide GALR1, GALR2, GALR3 -- PP : Gastrins Gastrin Cholecystokinin B receptor -- PP : Gastrins Cholecystokinin CCK Cholecystokinin receptors -- PP : Melanocortins Adrenocorticotropic hormone ACTH ACTH receptor -- PP : Melanocortins Proopiomelanocortin POMC Melanocortin 4 receptor -- PP : Melanocortins Melanocyte - stimulating hormones MSH Melanocortin receptors -- PP : Neurohypophyseals Vasopressin AVP Vasopressin receptors -- PP : Neurohypophyseals Oxytocin OT Oxytocin receptor -- PP : Neurohypophyseals Neurophysin I -- -- PP : Neurohypophyseals Neurophysin II -- -- PP : Neuromedins Neuromedin U NmU NmUR1, NmUR2 -- PP : Neuropeptide B / W Neuropeptide B NPB NPBW1, NPBW2 -- PP : Neuropeptide B / W Neuropeptide S NPS Neuropeptide S receptors -- PP : Neuropeptide Y Neuropeptide Y NY Neuropeptide Y receptors -- PP : Neuropeptide Y Pancreatic polypeptide PP -- -- PP : Neuropeptide Y Peptide YY PYY -- -- PP : Opioids Enkephalin δ - Opioid receptor -- PP : Opioids Dynorphin κ - Opioid receptor -- PP : Opioids Endorphin μ - Opioid receptors -- PP : Opioids Endomorphin μ - Opioid receptors -- PP : Orexins Orexin A OX - A Orexin receptors -- PP : Orexins Orexin B OX - B Orexin receptors -- PP : RFamides Kisspeptin KiSS GPR54 -- PP : RFamides Neuropeptide FF NPFF NPFF1, NPFF2 -- PP : RFamides Prolactin - releasing peptide PrRP PrRPR -- PP : RFamides Pyroglutamylated RFamide peptide QRFP GPR103 -- PP : Secretins Secretin Secretin receptor -- PP : Secretins Motilin Motilin receptor -- PP : Secretins Glucagon Glucagon receptor -- PP : Secretins Glucagon - like peptide - 1 GLP - 1 Glucagon - like peptide 1 receptor -- PP : Secretins Glucagon - like peptide - 2 GLP - 2 Glucagon - like peptide 2 receptor -- PP : Secretins Vasoactive intestinal peptide VIP Vasoactive intestinal peptide receptors -- PP : Secretins Growth hormone -- releasing hormone GHRH Growth hormone -- releasing hormone receptor -- PP : Somatostatins Somatostatin Somatostatin receptors -- PP : Tachykinins Neurokinin A -- -- PP : Tachykinins Neurokinin B -- -- PP : Tachykinins Substance P -- -- PP : Tachykinins Neuropeptide K -- -- PP : Other Agouti - related peptide AgRP Melanocortin receptor -- PP : Other N - Acetylaspartylglutamate NAAG Metabotropic glutamate receptor 3 ( mGluR3 ) -- PP : Other Cocaine - and amphetamine - regulated transcript CART Unknown G / G - coupled receptor -- PP : Other Bombesin -- -- PP : Other Gastrin releasing peptide GRP -- -- PP : Other Gonadotropin - releasing hormone GnRH GnRHR -- Gaseous signaling molecule Nitric oxide NO Soluble guanylyl cyclase -- Gaseous signaling molecule Carbon monoxide CO -- Heme bound to potassium channels Gaseous signaling molecule Hydrogen sulfide H2S -- -- Actions Neurons form elaborate networks through which nerve impulses -- action potentials -- travel. Each neuron has as many as 15,000 connections with neighboring neurons. Neurons do not touch each other ( except in the case of an electrical synapse through a gap junction ) ; instead, neurons interact at contact points called synapses : a junction within two nerve cells, consisting of a miniature gap within which impulses are carried by a neurotransmitter. A neuron transports its information by way of a nerve impulse called an action potential. When an action potential arrives at the synapse 's presynaptic terminal button, it may stimulate the release of neurotransmitters. These neurotransmitters are released into the synaptic cleft to bind onto the receptors of the postsynaptic membrane and influence another cell, either in an inhibitory or excitatory way. The next neuron may be connected to many more neurons, and if the total of excitatory influences minus inhibitory influences is great enough, it will also `` fire ''. That is to say, it will create a new action potential at its axon hillock, releasing neurotransmitters and passing on the information to yet another neighboring neuron. Excitatory and inhibitory A neurotransmitter can influence the function of a neuron through a remarkable number of mechanisms. In its direct actions in influencing a neuron 's electrical excitability, however, a neurotransmitter acts in only one of two ways : excitatory or inhibitory. A neurotransmitter influences trans - membrane ion flow either to increase ( excitatory ) or to decrease ( inhibitory ) the probability that the cell with which it comes in contact will produce an action potential. Thus, despite the wide variety of synapses, they all convey messages of only these two types, and they are labeled as such. Type I synapses are excitatory in their actions, whereas type II synapses are inhibitory. Each type has a different appearance and is located on different parts of the neurons under its influence. Each neuron receives thousands of excitatory and inhibitory signals every second. Type I ( excitatory ) synapses are typically located on the shafts or the spines of dendrites, whereas type II ( inhibitory ) synapses are typically located on a cell body. In addition, Type I synapses have round synaptic vesicles, whereas the vesicles of type II synapses are flattened. The material on the presynaptic and post-synaptic membranes is denser in a Type I synapse than it is in a type II, and the type I synaptic cleft is wider. Finally, the active zone on a Type I synapse is larger than that on a Type II synapse. The different locations of type I and type II synapses divide a neuron into two zones : an excitatory dendritic tree and an inhibitory cell body. From an inhibitory perspective, excitation comes in over the dendrites and spreads to the axon hillock to trigger an action potential. If the message is to be stopped, it is best stopped by applying inhibition on the cell body, close to the axon hillock where the action potential originates. Another way to conceptualize excitatory -- inhibitory interaction is to picture excitation overcoming inhibition. If the cell body is normally in an inhibited state, the only way to generate an action potential at the axon hillock is to reduce the cell body 's inhibition. In this `` open the gates '' strategy, the excitatory message is like a racehorse ready to run down the track, but first the inhibitory starting gate must be removed. Examples of important neurotransmitter actions As explained above, the only direct action of a neurotransmitter is to activate a receptor. Therefore, the effects of a neurotransmitter system depend on the connections of the neurons that use the transmitter, and the chemical properties of the receptors that the transmitter binds to. Here are a few examples of important neurotransmitter actions : Glutamate is used at the great majority of fast excitatory synapses in the brain and spinal cord. It is also used at most synapses that are `` modifiable '', i.e. capable of increasing or decreasing in strength. Modifiable synapses are thought to be the main memory - storage elements in the brain. Excessive glutamate release can overstimulate the brain and lead to excitotoxicity causing cell death resulting in seizures or strokes. Excitotoxicity has been implicated in certain chronic diseases including ischemic stroke, epilepsy, amyotrophic lateral sclerosis, Alzheimer 's disease, Huntington disease, and Parkinson 's disease. GABA is used at the great majority of fast inhibitory synapses in virtually every part of the brain. Many sedative / tranquilizing drugs act by enhancing the effects of GABA. Correspondingly, glycine is the inhibitory transmitter in the spinal cord. Acetylcholine was the first neurotransmitter discovered in the peripheral and central nervous systems. It activates skeletal muscles in the somatic nervous system and may either excite or inhibit internal organs in the autonomic system. It is distinguished as the transmitter at the neuromuscular junction connecting motor nerves to muscles. The paralytic arrow - poison curare acts by blocking transmission at these synapses. Acetylcholine also operates in many regions of the brain, but using different types of receptors, including nicotinic and muscarinic receptors. Dopamine has a number of important functions in the brain ; this includes regulation of motor behavior, pleasures related to motivation and also emotional arousal. It plays a critical role in the reward system ; Parkinson 's disease has been linked to low levels of dopamine and schizophrenia has been linked to high levels of dopamine. Serotonin is a monoamine neurotransmitter. Most is produced by and found in the intestine ( approximately 90 % ), and the remainder in central nervous system neurons. It functions to regulate appetite, sleep, memory and learning, temperature, mood, behaviour, muscle contraction, and function of the cardiovascular system and endocrine system. It is speculated to have a role in depression, as some depressed patients are seen to have lower concentrations of metabolites of serotonin in their cerebrospinal fluid and brain tissue. Norepinephrine which is synthesized in the central nervous system and sympathetic nerves, modulates the responses of the autonomic nervous system, the sleep patterns, focus and alertness. It is synthesized from tyrosine. Epinephrine which is also synthesized from tyrosine is released in the adrenal glands and the brainstem. It plays a role in sleep, with ones ability to become and stay alert, and the fight - or - flight response. Histamine works with the central nervous system ( CNS ), specifically the hypothalamus ( tuberomammillary nucleus ) and CNS mast cells. Brain neurotransmitter systems Neurons expressing certain types of neurotransmitters sometimes form distinct systems, where activation of the system affects large volumes of the brain, called volume transmission. Major neurotransmitter systems include the noradrenaline ( norepinephrine ) system, the dopamine system, the serotonin system, and the cholinergic system, among others. Trace amines have a modulatory effect on neurotransmission in monoamine pathways ( i.e., dopamine, norepinephrine, and serotonin pathways ) throughout the brain via signaling through trace amine - associated receptor 1. A brief comparison of these systems follows : Neurotransmitter systems in the brain System Pathway origin and projections Regulated cognitive processes and behaviors Noradrenaline system Noradrenergic pathways : Locus coeruleus ( LC ) projections LC → Amygdala and Hippocampus LC → Brain stem and Spinal cord LC → Cerebellum LC → Cerebral cortex LC → Hypothalamus LC → Tectum LC → Thalamus LC → Ventral tegmental area Lateral tegmental field ( LTF ) projections LTF → Brain stem and Spinal cord LTF → Olfactory bulb anxiety arousal ( wakefulness ) circadian rhythm cognitive control and working memory ( co-regulated by dopamine ) feeding and energy homeostasis medullary control of respiration negative emotional memory nociception ( perception of pain ) reward ( minor role ) Dopamine system Dopaminergic pathways : Ventral tegmental area ( VTA ) projections VTA → Amygdala VTA → Cingulate cortex VTA → Hippocampus VTA → Ventral striatum ( Mesolimbic pathway ) VTA → Olfactory bulb VTA → Prefrontal cortex ( Mesocortical pathway ) Nigrostriatal pathway Substantia nigra pars compacta → Dorsal striatum Tuberoinfundibular pathway Arcuate nucleus → Median eminence arousal ( wakefulness ) aversion cognitive control and working memory ( co-regulated by norepinephrine ) emotion and mood motivation ( motivational salience ) motor function positive reinforcement reward ( primary mediator ) sexual arousal, orgasm, and refractory period ( via neuroendocrine regulation ) Histamine system Histaminergic pathways : Tuberomammillary nucleus ( TMN ) projections TMN → Cerebral cortex TMN → Hippocampus TMN → Neostriatum TMN → Nucleus accumbens TMN → Amygdala TMN → Hypothalamus arousal ( wakefulness ) feeding and energy homeostasis learning memory Serotonin system Serotonergic pathways : Caudal nuclei ( CN ) : Raphe magnus, raphe pallidus, and raphe obscurus Caudal projections CN → Cerebral cortex CN → Thalamus CN → Caudate - putamen and nucleus accumbens CN → Substantia nigra and ventral tegmental area Rostral nuclei ( RN ) : Nucleus linearis, dorsal raphe, medial raphe, and raphe pontis Rostral projections RN → Amygdala RN → Cingulate cortex RN → Hippocampus RN → Hypothalamus RN → Neocortex RN → Septum RN → Thalamus RN → Ventral tegmental area arousal ( wakefulness ) body temperature regulation emotion and mood, potentially including aggression feeding and energy homeostasis reward ( minor role ) sensory perception Acetylcholine system Cholinergic pathways : Forebrain cholinergic nuclei ( FCN ) : Nucleus basalis of Meynert, medial septal nucleus, and diagonal band Forebrain nuclei projections FCN → Hippocampus FCN → Cerebral cortex FCN → Limbic cortex and sensory cortex Brainstem cholinergic nuclei ( BCN ) : Pedunculopontine nucleus, laterodorsal tegmentum, medial habenula, and parabigeminal nucleus Brainstem nuclei projections BCN → Ventral tegmental area BCN → Thalamus arousal ( wakefulness ) emotion and mood learning motor function motivation ( motivational salience ) short - term memory reward ( minor role ) Drug effects Understanding the effects of drugs on neurotransmitters comprises a significant portion of research initiatives in the field of neuroscience. Most neuroscientists involved in this field of research believe that such efforts may further advance our understanding of the circuits responsible for various neurological diseases and disorders, as well as ways to effectively treat and someday possibly prevent or cure such illnesses. Drugs can influence behavior by altering neurotransmitter activity. For instance, drugs can decrease the rate of synthesis of neurotransmitters by affecting the synthetic enzyme ( s ) for that neurotransmitter. When neurotransmitter syntheses are blocked, the amount of neurotransmitters available for release becomes substantially lower, resulting in a decrease in neurotransmitter activity. Some drugs block or stimulate the release of specific neurotransmitters. Alternatively, drugs can prevent neurotransmitter storage in synaptic vesicles by causing the synaptic vesicle membranes to leak. Drugs that prevent a neurotransmitter from binding to its receptor are called receptor antagonists. For example, drugs used to treat patients with schizophrenia such as haloperidol, chlorpromazine, and clozapine are antagonists at receptors in the brain for dopamine. Other drugs act by binding to a receptor and mimicking the normal neurotransmitter. Such drugs are called receptor agonists. An example of a receptor agonist is Valium, a benzodiazepine that mimics effects of the endogenous neurotransmitter gamma - aminobutyric acid ( GABA ) to decrease anxiety. Other drugs interfere with the deactivation of a neurotransmitter after it has been released, thereby prolonging the action of a neurotransmitter. This can be accomplished by blocking re-uptake or inhibiting degradative enzymes. Lastly, drugs can also prevent an action potential from occurring, blocking neuronal activity throughout the central and peripheral nervous system. Drugs such as tetrodotoxin that block neural activity are typically lethal. Drugs targeting the neurotransmitter of major systems affect the whole system, which can explain the complexity of action of some drugs. Cocaine, for example, blocks the re-uptake of dopamine back into the presynaptic neuron, leaving the neurotransmitter molecules in the synaptic gap for an extended period of time. Since the dopamine remains in the synapse longer, the neurotransmitter continues to bind to the receptors on the postsynaptic neuron, eliciting a pleasurable emotional response. Physical addiction to cocaine may result from prolonged exposure to excess dopamine in the synapses, which leads to the downregulation of some post-synaptic receptors. After the effects of the drug wear off, an individual can become depressed due to decreased probability of the neurotransmitter binding to a receptor. Fluoxetine is a selective serotonin re-uptake inhibitor ( SSRI ), which blocks re-uptake of serotonin by the presynaptic cell which increases the amount of serotonin present at the synapse and furthermore allows it to remain there longer, providing potential for the effect of naturally released serotonin. AMPT prevents the conversion of tyrosine to L - DOPA, the precursor to dopamine ; reserpine prevents dopamine storage within vesicles ; and deprenyl inhibits monoamine oxidase ( MAO ) - B and thus increases dopamine levels. Drug - Neurotransmitter Interactions Drug Interacts with : Receptor Interaction : Type Effects Botulinum Toxin ( Botox ) Acetylcholine - Antagonist Blocks acetylcholine release in PNS Prevents muscle contractions Black Widow Spider Venom Acetylcholine - Agonist Promotes acetylcholine release in PNS Stimulates muscle contractions Neostigmine Acetylcholine - - Interferes with acetylcholinerase activity Increases effects of ACh at receptors Used to treat myasthenia gravis Nicotine Acetylcholine Nicotinic ( skeletal muscle ) Agonist Increases ACh activity Increases attention Reinforcing effects d - tubocurarine Acetylcholine Nicotinic ( skeletal muscle ) Antagonist Decreases activity at receptor site Curare Acetylcholine Nicotinic ( skeletal muscle ) Antagonist Decreases ACh activity Prevents muscle contractions Muscarine Acetylcholine Muscarinic ( heart and smooth muscle ) Agonist Increases ACh activity Toxic Hallucinogenic effects Atropine Acetylcholine Muscarinic ( heart and smooth muscle ) Antagonist Blocks pupil constriction Blocks saliva production Scopolamine ( Hyoscine ) Acetylcholine Muscarinic ( heart and smooth muscle ) Antagonist Treats motion sickness and postoperative nausea and vomiting AMPT Dopamine / norepinephrine - - Inactivates tyrosine hydroxylase and inhibits dopamine production Reserpine Dopamine - - Prevents storage of dopamine and other monoamines in synaptic vesicles Causes sedation and depression Apomorphine Dopamine D2 Receptor ( presynaptic autoreceptors / postsynaptic receptors ) Antagonist ( low dose ) / Direct agonist ( high dose ) Low dose : blocks autoreceptors High dose : stimulates postsynaptic receptors Amphetamine Dopamine / norepinephrine - Indirect agonist Releases dopamine, noradrenaline, and serotonin Blocks reuptake Methamphetamine Dopamine / norepinephrine - - Releases dopamine and noradrenaline Blocks reuptake Methylphenidate Dopamine - - Blocks reuptake Enhances attention and impulse control in ADHD Cocaine Dopamine - Agonist Blocks reuptake into presynapse Blocks voltage - dependent sodium channels Can be used as a topical anesthetic ( eye drops ) Deprenyl Dopamine - Agonist Inhibits MAO - B Prevents destruction of dopamine Chlorpromazine Dopamine D2 Receptors Antagonist Blocks D2 receptors Alleviates hallucinations MPTP Dopamine - - Results in Parkinson like symptoms PCPA Serotonin ( 5 - HT ) - Antagonist Disrupts serotonin synthesis by blocking the activity of tryptophan hydroxylase Ondanestron Serotonin ( 5 - HT ) 5 - HT receptors Antagonist Reduces side effects of chemotherapy and radiation Reduces nausea and vomiting Buspirone Serotonin ( 5 - HT ) 5 - HT receptors Partial Agonist Treats symptoms of anxiety and depression Fluoxetine Serotonin ( 5 - HT ) - SSRI Inhibits reuptake of serotonin Treats depression, some anxiety disorders, and OCD Fenfluramine Serotonin ( 5 - HT ) - - Causes release of serotonin Inhibits reuptake of serotonin Used as an appetite suppressant Lysergic acid diethylamide Serotonin ( 5 - HT ) Post-synaptic 5 - HT receptors Direct Agonist Produces visual perception distortions Stimulates 5 - HT receptors in forebrain Methylenedioxymethamphetamine ( MDMA ) Serotonin ( 5 - HT ) / norepinphrine - - Stimulates release of serotonin and norepinephrine and inhibits the reuptake Causes excitatory and hallucinogenic effects Strychnine Glycine - Antagonist Causes severe muscle spasms Diphenyldramine Histamine Crosses blood brain barrier to cause drowsiness Tetrahydrocannabinol ( THC ) Endocannabinoids Cannabinoid ( CB ) receptors Agonist Produces analgesia and sedation Increases appetite Cognitive effects Rimonabant Endocannabinoids Cannabinoid ( CB ) receptors Antagonist Suppresses appetite Used in smoking cessation MAFP Endocannabinoids - - Inhibits FAAH Used in research to increase cannabinoid system activity AM1172 Endocannabinoids - - Blocks cannabinoid reuptake Used in research to increase cannabinoid system activity Anandamide ( endogenous ) - Cannabinoid ( CB ) receptors ; 5 - HT receptors - Reduce nausea and vomiting Caffeine Adenosine Adenosine receptors Antagonist Blocks adenosine receptors Increases wakefullness PCP Glutamate NMDA receptor Indirect Antagonist Blocks PCP binding site Prevents calcium ions from entering neurons Impairs learning AP5 Glutamate NMDA receptor Antagonist Blocks glutamate binding site on NMDA receptor Impairs synaptic plasticity and certain forms of learning NMDA Glutamate NMDA receptor Agonist Used in research to study NMDA receptor AMPA Glutamate AMPA receptor Agonist Used in research to study AMPA receptor Ketamine Glutamate Kainate receptor Agonist Used in research to study Kainate receptor Allyglycine GABA - - Inhibits GABA synthesis Causes seizures Muscimol GABA GABA receptor Agonist Causes sedation Bicuculine GABA GABA receptor Antagonist Causes Seizures Benzodiazepines GABA GABA receptor Indirect agonists Anxiolytic, sedation, memory impairment, muscle relaxation Barbiturates GABA GABA receptor Indirect agonists Sedation, memory impairment, muscle relaxation Alcohol GABA GABA receptor Indirect agonist Sedation, memory impairment, muscle relaxation Picrotoxin GABA GABA receptor Indirect antagonist High doses cause seizures Tiagabine GABA - Antagonist GABA transporter antagonist Increase availability of GABA Reduces the likelihood of seizures Moclobemide Norepinephrine - Agonist Blocks MAO - A to treat depression Idazoxan Norepinephrine alpha - 2 adrenergic autoreceptors Agonist Blocks alpha - 2 autoreceptors Used to study norepinephrine system Fusaric acid Norepinephrine - - Inhibits activity of dopamine beta - hydroxylase which blocks the production of norepinephrine Used to study norepinephrine system without affecting dopamine system Opiates ( Opium, morphine, heroin, and oxycodone ) Opoids Opioid receptor Agonists Analgesia, sedation, and reinforcing effects Naloxone Opoids - Antagonist Reverses opiate intoxication or overdo Agonists Main article : Agonist This section needs expansion with : coverage of full agonists and their distinction from partial agonist and inverse agonist... You can help by adding to it. ( August 2015 ) An agonist is a chemical capable of binding to a receptor, such as a neurotransmitter receptor, and initiating the same reaction typically produced by the binding of the endogenous substance. An agonist of a neurotransmitter will thus initiate the same receptor response as the transmitter. In neurons, an agonist drug may activate neurotransmitter receptors either directly or indirectly. Direct - binding agonists can be further characterized as full agonists, partial agonists, inverse agonists. Direct agonists act similar to a neurotransmitter by binding directly to its associated receptor site ( s ), which may be located on the presynaptic neuron or postsynaptic neuron, or both. Typically, neurotransmitter receptors are located on the postsynaptic neuron, while neurotransmitter autoreceptors are located on the presynaptic neuron, as is the case for monoamine neurotransmitters ; in some cases, a neurotransmitter utilizes retrograde neurotransmission, a type of feedback signaling in neurons where the neurotransmitter is released postsynaptically and binds to target receptors located on the presynaptic neuron. Nicotine, a compound found in tobacco, is a direct agonist of most nicotinic acetylcholine receptors, mainly located in cholinergic neurons. Opiates, such as morphine, heroin, hydrocodone, oxycodone, codeine, and methadone, are μ - opioid receptor agonists ; this action mediates their euphoriant and pain relieving properties. Indirect agonists increase the binding of neurotransmitters at their target receptors by stimulating the release or preventing the reuptake of neurotransmitters. Some indirect agonists trigger neurotransmitter release and prevent neurotransmitter reuptake. Amphetamine, for example, is an indirect agonist of postsynaptic dopamine, norepinephrine, and serotonin receptors in each their respective neurons ; it produces both neurotransmitter release into the presynaptic neuron and subsequently the synaptic cleft and prevents their reuptake from the synaptic cleft by activating TAAR1, a presynaptic G protein - coupled receptor, and binding to a site on VMAT2, a type of monoamine transporter located on synaptic vesicles within monoamine neurons. Antagonists Main article : Receptor antagonist An antagonist is a chemical that acts within the body to reduce the physiological activity of another chemical substance ( as an opiate ) ; especially one that opposes the action on the nervous system of a drug or a substance occurring naturally in the body by combining with and blocking its nervous receptor. There are two main types of antagonist : direct - acting Antagonist and indirect - acting Antagonists : Direct - acting antagonist - which takes up space present on receptors which are otherwise taken up by neurotransmitters themselves. This results in neurotransmitters being blocked from binding to the receptors. The most common is called Atropine. Indirect - acting antagonist - drugs that inhibit the release / production of neurotransmitters ( e.g., Reserpine ). Drug antagonists An antagonist drug is one that attaches ( or binds ) to a site called a receptor without activating that receptor to produce a biological response. It is therefore said to have no intrinsic activity. An antagonist may also be called a receptor `` blocker '' because they block the effect of an agonist at the site. The pharmacological effects of an antagonist therefore result in preventing the corresponding receptor site 's agonists ( e.g., drugs, hormones, neurotransmitters ) from binding to and activating it. Antagonists may be `` competitive '' or `` irreversible ''. A competitive antagonist competes with an agonist for binding to the receptor. As the concentration of antagonist increases, the binding of the agonist is progressively inhibited, resulting in a decrease in the physiological response. High concentration of an antagonist can completely inhibit the response. This inhibition can be reversed, however, by an increase of the concentration of the agonist, since the agonist and antagonist compete for binding to the receptor. Competitive antagonists, therefore, can be characterized as shifting the dose - response relationship for the agonist to the right. In the presence of a competitive antagonist, it takes an increased concentration of the agonist to produce the same response observed in the absence of the antagonist. An irreversible antagonist binds so strongly to the receptor as to render the receptor unavailable for binding to the agonist. Irreversible antagonists may even form covalent chemical bonds with the receptor. In either case, if the concentration of the irreversible antagonist is high enough, the number of unbound receptors remaining for agonist binding may be so low that even high concentrations of the agonist do not produce the maximum biological response. Precursors Biosynthetic pathways for catecholamines and trace amines in the human brain L - Phenylalanine L - Tyrosine L - DOPA Epinephrine Phenethylamine p - Tyramine Dopamine Norepinephrine N - Methylphenethylamine N - Methyltyramine p - Octopamine Synephrine 3 - Methoxytyramine AADC AADC AADC primary pathway PNMT PNMT PNMT PNMT AAAH AAAH brain CYP2D6 minor pathway COMT DBH DBH In humans, catecholamines and phenethylaminergic trace amines are derived from the amino acid L - phenylalanine. While intake of neurotransmitter precursors does increase neurotransmitter synthesis, evidence is mixed as to whether neurotransmitter release and postsynaptic receptor firing is increased. Even with increased neurotransmitter release, it is unclear whether this will result in a long - term increase in neurotransmitter signal strength, since the nervous system can adapt to changes such as increased neurotransmitter synthesis and may therefore maintain constant firing. Some neurotransmitters may have a role in depression and there is some evidence to suggest that intake of precursors of these neurotransmitters may be useful in the treatment of mild and moderate depression. Catecholamine and trace amine precursors L - DOPA, a precursor of dopamine that crosses the blood -- brain barrier, is used in the treatment of Parkinson 's disease. For depressed patients where low activity of the neurotransmitter norepinephrine is implicated, there is only little evidence for benefit of neurotransmitter precursor administration. L - phenylalanine and L - tyrosine are both precursors for dopamine, norepinephrine, and epinephrine. These conversions require vitamin B6, vitamin C, and S - adenosylmethionine. A few studies suggest potential antidepressant effects of L - phenylalanine and L - tyrosine, but there is much room for further research in this area. Serotonin precursors Administration of L - tryptophan, a precursor for serotonin, is seen to double the production of serotonin in the brain. It is significantly more effective than a placebo in the treatment of mild and moderate depression. This conversion requires vitamin C. 5 - hydroxytryptophan ( 5 - HTP ), also a precursor for serotonin, is more effective than a placebo. Diseases and disorders Diseases and disorders may also affect specific neurotransmitter systems. For example, problems in producing dopamine can result in Parkinson 's disease, a disorder that affects a person 's ability to move as they want to, resulting in stiffness, tremors or shaking, and other symptoms. Some studies suggest that having too little or too much dopamine or problems using dopamine in the thinking and feeling regions of the brain may play a role in disorders like schizophrenia or attention deficit hyperactivity disorder ( ADHD ). Similarly, after some research suggested that drugs that block the recycling, or reuptake, of serotonin seemed to help some people diagnosed with depression, it was theorized that people with depression might have lower - than - normal serotonin levels. Though widely popularized, this theory was not borne out in subsequent research. Furthermore, problems with producing or using glutamate have been suggestively and tentatively linked to many mental disorders, including autism, obsessive compulsive disorder ( OCD ), schizophrenia, and depression. CAPON Binds Nitric Oxide Synthase, Regulating NMDA Receptor -- Mediated Glutamate Neurotransmission Neurotransmitter imbalance Generally, there are no scientifically established `` norms '' for appropriate levels or `` balances '' of different neurotransmitters. It is in most cases pragmatically impossible to even measure levels of neurotransmitters in a brain or body at any distinct moments in time. Neurotransmitters regulate each other 's release, and weak consistent imbalances in this mutual regulation were linked to temperament in healthy people. Strong imbalances or disruptions to neurotransmitter systems have been associated with many diseases and mental disorders. These include Parkinson 's, depression, insomnia, Attention Deficit Hyperactivity Disorder ( ADHD ), anxiety, memory loss, dramatic changes in weight and addictions. Chronic physical or emotional stress can be a contributor to neurotransmitter system changes. Genetics also plays a role in neurotransmitter activities. Apart from recreational use, medications that directly and indirectly interact one or more transmitter or its receptor are commonly prescribed for psychiatric and psychological issues. Notably, drugs interacting with serotonin and norepinephrine are prescribed to patients with problems such as depression and anxiety -- though the notion that there is much solid medical evidence to support such interventions has been widely criticized. Elimination of neurotransmitters A neurotransmitter must be broken down once it reaches the post-synaptic cell to prevent further excitatory or inhibitory signal transduction. This allows new signals to be produced from the adjacent nerve cells. When the neurotransmitter has been secreted into the synaptic cleft, it binds to specific receptors on the postsynaptic cell, thereby generating a postsynaptic electrical signal. The transmitter must then be removed rapidly to enable the postsynaptic cell to engage in another cycle of neurotransmitter release, binding, and signal generation. Neurotransmitters are terminated in three different ways : Diffusion -- the neurotransmitter detaches from receptor, drifting out of the synaptic cleft, here it becomes absorbed by glial cells. Enzyme degradation -- special chemicals called enzymes break it down. Reuptake -- re-absorption of a neurotransmitter into the neuron. Transporters, or membrane transport proteins, pump neurotransmitters from the synaptic cleft back into axon terminals ( the presynaptic neuron ) where they are stored. For example, choline is taken up and recycled by the pre-synaptic neuron to synthesize more ACh. Other neurotransmitters such as dopamine are able to diffuse away from their targeted synaptic junctions and are eliminated from the body via the kidneys, or destroyed in the liver. Each neurotransmitter has very specific degradation pathways at regulatory points, which may be targeted by the body 's regulatory system or by recreational drugs. See also Neuroscience portal Neurotransmitter release Kiss - and - run fusion Neuropsychopharmacology Neuroendocrine Neuroendocrinology Natural neuroactive substance Notes Jump up ^ In the central nervous system, anandamide other endocannabinoids utilize retrograde neurotransmission, since their release is postsynaptic, while their target receptor, cannabinoid receptor 1 ( CB1 ), is presynaptic. The cannabis plant contains Δ - tetrahydrocannabinol, which is a direct agonist at CB1. References Jump up ^ Lodish, H. ; Berk, A. ; Zipursky, S.L. ( 2000 ). Molecular Cell Biology : Section 21.4 Neurotransmitters, Synapses, and Impulse Transmission ( 4th ed. ). New York : W.H. Freeman. Jump up ^ Cherry, Kendra. `` What is a Neurotransmitter ? ''. Retrieved 6 October 2014. Jump up ^ `` Neuropeptide database ''. Jump up ^ `` Neuropeptides. IUPHAR / BPS Guide to pharmacology ''. Jump up ^ Elias, L. J, & Saucier, D.M. ( 2005 ). Neuropsychology : Clinical and Experimental Foundations. Boston : Pearson ^ Jump up to : Robert Sapolsky ( 2005 ). `` Biology and Human Behavior : The Neurological Origins of Individuality, 2nd edition ''. The Teaching Company. see pages 13 & 14 of Guide Book Jump up ^ Saladin, Kenneth S. Anatomy and Physiology : The Unity of Form and Function. McGraw Hill. 2009 ISBN 0 - 07 - 727620 - 5 Jump up ^ `` Junctions Between Cells ''. Retrieved 22 November 2010. Jump up ^ University, S. Marc Breedlove, Michigan State University, Neil V. Watson, Simon Fraser ( 2013 ). Biological psychology : an introduction to behavioral, cognitive, and clinical neuroscience ( Seventh ed. ). Sunderland, MA : Sinauer Associates. ISBN 978 - 0878939275. ^ Jump up to : Whishaw, Bryan Kolb, Ian Q. ( 2014 ). An introduction to brain and behavior ( 4th ed. ). New York, NY : Worth Publishers. pp. 150 -- 151. ISBN 978 - 1429242288. Jump up ^ Snyder SH, Innis RB ( 1979 ). `` Peptide neurotransmitters ''. Annu. Rev. Biochem. 48 : 755 -- 82. doi : 10.1146 / annurev. bi. 48.070179. 003543. PMID 38738. Jump up ^ Kodirov, Sodikdjon A., Shuichi Takizawa, Jamie Joseph, Eric R. Kandel, Gleb P. Shumyatsky, and Vadim Y. Bolshakov. Synaptically released zinc gates long - term potentiation in fear conditioning pathways. PNAS, 10 October 2006. 103 ( 41 ) : 15218 - 23. doi : 10.1073 / pnas. 0607131103 Jump up ^ `` International Symposium on Nitric Oxide - Dr. John Andrews - MaRS ''. MaRS. Archived from the original on 14 October 2014. Jump up ^ `` Dopamine : Biological activity ''. IUPHAR / BPS guide to pharmacology. International Union of Basic and Clinical Pharmacology. Retrieved 29 January 2016. Jump up ^ Grandy DK, Miller GM, Li JX ( February 2016 ). `` '' TAARgeting Addiction `` - The Alamo Bears Witness to Another Revolution : An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference ''. Drug Alcohol Depend. 159 : 9 -- 16. doi : 10.1016 / j. drugalcdep. 2015.11. 014. PMC 4724540. PMID 26644139. TAAR1 is a high - affinity receptor for METH / AMPH and DA Jump up ^ Lin Y, Hall RA, Kuhar MJ ( October 2011 ). `` CART peptide stimulation of G protein - mediated signaling in differentiated PC12 cells : identification of PACAP 6 -- 38 as a CART receptor antagonist ''. Neuropeptides. 45 ( 5 ) : 351 -- 358. doi : 10.1016 / j. npep. 2011.07. 006. PMC 3170513. PMID 21855138. Jump up ^ Whishaw, Bryan Kolb, Ian Q. ( 2014 ). An introduction to brain and behavior ( 4th ed. ). New York, NY : Worth Publishers. ISBN 978 - 1429242288. Jump up ^ Gross L ( 2006 ). `` '' Supporting '' players take the lead in protecting the overstimulated brain ``. PLoS Biol. 4 : e371. doi : 10.1371 / journal. pbio. 0040371. PMC 1609133. PMID 20076484. Jump up ^ Yang JL, Sykora P, Wilson DM, Mattson MP, Bohr VA ( August 2011 ). `` The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency ''. Mech. Ageing Dev. 132 ( 8 -- 9 ) : 405 -- 11. doi : 10.1016 / j. mad. 2011.06. 005. PMC 3367503. PMID 21729715. Jump up ^ Orexin receptor antagonists a new class of sleeping pill, National Sleep Foundation. Jump up ^ `` Acetylcholine Receptors ''. Ebi.ac.uk. Retrieved 25 August 2014. Jump up ^ Schacter, Gilbert and Weger. Psychology. United States of America. 2009. Print. ^ Jump up to : University of Bristol. `` Introduction to Serotonin ''. Retrieved 15 October 2009. ^ Jump up to : Miller GM ( January 2011 ). `` The emerging role of trace amine - associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity ''. J. Neurochem. 116 ( 2 ) : 164 -- 176. doi : 10.1111 / j. 1471 - 4159.2010. 07109. x. PMC 3005101. PMID 21073468. ^ Jump up to : Eiden LE, Weihe E ( January 2011 ). `` VMAT2 : a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse ''. Ann. N.Y. Acad. Sci. 1216 : 86 -- 98. doi : 10.1111 / j. 1749 - 6632.2010. 05906. x. PMC 4183197. PMID 21272013. VMAT2 is the CNS vesicular transporter for not only the biogenic amines DA, NE, EPI, 5 - HT, and HIS, but likely also for the trace amines TYR, PEA, and thyronamine ( THYR )... ( Trace aminergic ) neurons in mammalian CNS would be identifiable as neurons expressing VMAT2 for storage, and the biosynthetic enzyme aromatic amino acid decarboxylase ( AADC ). ^ Jump up to : Malenka RC, Nestler EJ, Hyman SE ( 2009 ). `` Chapter 6 : Widely Projecting Systems : Monoamines, Acetylcholine, and Orexin ''. In Sydor A, Brown RY. Molecular Neuropharmacology : A Foundation for Clinical Neuroscience ( 2nd ed. ). New York : McGraw - Hill Medical. p. 155. ISBN 9780071481274. Different subregions of the VTA receive glutamatergic inputs from the prefrontal cortex, orexinergic inputs from the lateral hypothalamus, cholinergic and also glutamatergic and GABAergic inputs from the laterodorsal tegmental nucleus and pedunculopontine nucleus, noradrenergic inputs from the locus ceruleus, serotonergic inputs from the raphe nuclei, and GABAergic inputs from the nucleus accumbens and ventral pallidum. Jump up ^ Malenka RC, Nestler EJ, Hyman SE ( 2009 ). `` Chapter 6 : Widely Projecting Systems : Monoamines, Acetylcholine, and Orexin ''. In Sydor A, Brown RY. Molecular Neuropharmacology : A Foundation for Clinical Neuroscience ( 2nd ed. ). New York : McGraw - Hill Medical. pp. 145, 156 -- 157. ISBN 9780071481274. Descending NE fibers modulate afferent pain signals... The locus ceruleus ( LC ), which is located on the floor of the fourth ventricle in the rostral pons, contains more than 50 % of all noradrenergic neurons in the brain ; it innervates both the forebrain ( eg, it provides virtually all the NE to the cerebral cortex ) and regions of the brainstem and spinal cord... The other noradrenergic neurons in the brain occur in loose collections of cells in the brainstem, including the lateral tegmental regions. These neurons project largely within the brainstem and spinal cord. NE, along with 5HT, ACh, histamine, and orexin, is a critical regulator of the sleep - wake cycle and of levels of arousal... LC firing may also increase anxiety... Stimulation of β - adrenergic receptors in the amygdala results in enhanced memory for stimuli encoded under strong negative emotion... Epinephrine occurs in only a small number of central neurons, all located in the medulla. Epinephrine is involved in visceral functions, such as control of respiration. ^ Jump up to : Rang, H.P. ( 2003 ). Pharmacology. Edinburgh : Churchill Livingstone. pp. 474 for noradrenaline system, page 476 for dopamine system, page 480 for serotonin system and page 483 for cholinergic system. ISBN 0 - 443 - 07145 - 4. ^ Jump up to : Iwańczuk W, Guźniczak P ( 2015 ). `` Neurophysiological foundations of sleep, arousal, awareness and consciousness phenomena. Part 1 ''. Anaesthesiol Intensive Ther. 47 ( 2 ) : 162 -- 167. doi : 10.5603 / AIT. 2015.0015. PMID 25940332. The ascending reticular activating system ( ARAS ) is responsible for a sustained wakefulness state... The thalamic projection is dominated by cholinergic neurons originating from the pedunculopontine tegmental nucleus of pons and midbrain ( PPT ) and laterodorsal tegmental nucleus of pons and midbrain ( LDT ) nuclei ( 17, 18 ). The hypothalamic projection involves noradrenergic neurons of the locus coeruleus ( LC ) and serotoninergic neurons of the dorsal and median raphe nuclei ( DR ), which pass through the lateral hypothalamus and reach axons of the histaminergic tubero - mamillary nucleus ( TMN ), together forming a pathway extending into the forebrain, cortex and hippocampus. Cortical arousal also takes advantage of dopaminergic neurons of the substantia nigra ( SN ), ventral tegmenti area ( VTA ) and the periaqueductal grey area ( PAG ). Fewer cholinergic neurons of the pons and midbrain send projections to the forebrain along the ventral pathway, bypassing the thalamus ( 19, 20 ). ^ Jump up to : Malenka RC, Nestler EJ, Hyman SE ( 2009 ). `` Chapter 12 : Sleep and Arousal ''. In Sydor A, Brown RY. Molecular Neuropharmacology : A Foundation for Clinical Neuroscience ( 2nd ed. ). New York, USA : McGraw - Hill Medical. p. 295. ISBN 9780071481274. The ARAS is a complex structure consisting of several different circuits including the four monoaminergic pathways... The norepinephrine pathway originates from the locus ceruleus ( LC ) and related brainstem nuclei ; the serotonergic neurons originate from the raphe nuclei within the brainstem as well ; the dopaminergic neurons originate in ventral tegmental area ( VTA ) ; and the histaminergic pathway originates from neurons in the tuberomammillary nucleus ( TMN ) of the posterior hypothalamus. As discussed in Chapter 6, these neurons project widely throughout the brain from restricted collections of cell bodies. Norepinephrine, serotonin, dopamine, and histamine have complex modulatory functions and, in general, promote wakefulness. The PT in the brain stem is also an important component of the ARAS. Activity of PT cholinergic neurons ( REM - on cells ) promotes REM sleep. During waking, REM - on cells are inhibited by a subset of ARAS norepinephrine and serotonin neurons called REM - off cells. Jump up ^ Rinaman L ( February 2011 ). `` Hindbrain noradrenergic A2 neurons : diverse roles in autonomic, endocrine, cognitive, and behavioral functions ''. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300 ( 2 ) : R222 -- 35. doi : 10.1152 / ajpregu. 00556.2010. PMC 3043801. PMID 20962208. Jump up ^ Malenka RC, Nestler EJ, Hyman SE ( 2009 ). `` Chapter 6 : Widely Projecting Systems : Monoamines, Acetylcholine, and Orexin ''. In Sydor A, Brown RY. Molecular Neuropharmacology : A Foundation for Clinical Neuroscience ( 2nd ed. ). New York : McGraw - Hill Medical. pp. 147 -- 148, 154 -- 157. ISBN 9780071481274. Neurons from the SNc densely innervate the dorsal striatum where they play a critical role in the learning and execution of motor programs. Neurons from the VTA innervate the ventral striatum ( nucleus accumbens ), olfactory bulb, amygdala, hippocampus, orbital and medial prefrontal cortex, and cingulate cortex. VTA DA neurons play a critical role in motivation, reward - related behavior, attention, and multiple forms of memory... Thus, acting in diverse terminal fields, dopamine confers motivational salience ( `` wanting '' ) on the reward itself or associated cues ( nucleus accumbens shell region ), updates the value placed on different goals in light of this new experience ( orbital prefrontal cortex ), helps consolidate multiple forms of memory ( amygdala and hippocampus ), and encodes new motor programs that will facilitate obtaining this reward in the future ( nucleus accumbens core region and dorsal striatum )... DA has multiple actions in the prefrontal cortex. It promotes the `` cognitive control '' of behavior : the selection and successful monitoring of behavior to facilitate attainment of chosen goals. Aspects of cognitive control in which DA plays a role include working memory, the ability to hold information `` on line '' in order to guide actions, suppression of prepotent behaviors that compete with goal - directed actions, and control of attention and thus the ability to overcome distractions... Noradrenergic projections from the LC thus interact with dopaminergic projections from the VTA to regulate cognitive control... Jump up ^ Calipari ES, Bagot RC, Purushothaman I, Davidson TJ, Yorgason JT, Peña CJ, Walker DM, Pirpinias ST, Guise KG, Ramakrishnan C, Deisseroth K, Nestler EJ ( February 2016 ). `` In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward ''. Proc. Natl. Acad. Sci. U.S.A. 113 : 2726 -- 31. doi : 10.1073 / pnas. 1521238113. PMC 4791010. PMID 26831103. Previous work has demonstrated that optogenetically stimulating D1 MSNs promotes reward, whereas stimulating D2 MSNs produces aversion. Jump up ^ Ikemoto S ( 2010 ). `` Brain reward circuitry beyond the mesolimbic dopamine system : a neurobiological theory ''. Neurosci Biobehav Rev. 35 ( 2 ) : 129 -- 50. doi : 10.1016 / j. neubiorev. 2010.02. 001. PMC 2894302. PMID 20149820. Recent studies on intracranial self - administration of neurochemicals ( drugs ) found that rats learn to self - administer various drugs into the mesolimbic dopamine structures -- the posterior ventral tegmental area, medial shell nucleus accumbens and medial olfactory tubercle... In the 1970s it was recognized that the olfactory tubercle contains a striatal component, which is filled with GABAergic medium spiny neurons receiving glutamatergic inputs form cortical regions and dopaminergic inputs from the VTA and projecting to the ventral pallidum just like the nucleus accumbens Figure 3 : The ventral striatum and self - administration of amphetamine Jump up ^ Malenka RC, Nestler EJ, Hyman SE ( 2009 ). `` Chapter 6 : Widely Projecting Systems : Monoamines, Acetylcholine, and Orexin ''. In Sydor A, Brown RY. Molecular Neuropharmacology : A Foundation for Clinical Neuroscience ( 2nd ed. ). New York : McGraw - Hill Medical. pp. 175 -- 176. ISBN 9780071481274. Within the brain, histamine is synthesized exclusively by neurons with their cell bodies in the tuberomammillary nucleus ( TMN ) that lies within the posterior hypothalamus. There are approximately 64000 histaminergic neurons per side in humans. These cells project throughout the brain and spinal cord. Areas that receive especially dense projections include the cerebral cortex, hippocampus, neostriatum, nucleus accumbens, amygdala, and hypothalamus... While the best characterized function of the histamine system in the brain is regulation of sleep and arousal, histamine is also involved in learning and memory... It also appears that histamine is involved in the regulation of feeding and energy balance. Jump up ^ Malenka RC, Nestler EJ, Hyman SE ( 2009 ). `` Chapter 6 : Widely Projecting Systems : Monoamines, Acetylcholine, and Orexin ''. In Sydor A, Brown RY. Molecular Neuropharmacology : A Foundation for Clinical Neuroscience ( 2nd ed. ). New York : McGraw - Hill Medical. pp. 158 -- 160. ISBN 9780071481274. ( The ) dorsal raphe preferentially innervates the cerebral cortex, thalamus, striatal regions ( caudate - putamen and nucleus accumbens ), and dopaminergic nuclei of the midbrain ( eg, the substantia nigra and ventral tegmental area ), while the median raphe innervates the hippocampus, septum, and other structures of the limbic forebrain... it is clear that 5HT influences sleep, arousal, attention, processing of sensory information in the cerebral cortex, and important aspects of emotion ( likely including aggression ) and mood regulation... The rostral nuclei, which include the nucleus linearis, dorsal raphe, medial raphe, and raphe pontis, innervate most of the brain, including the cerebellum. The caudal nuclei, which comprise the raphe magnus, raphe pallidus, and raphe obscuris, have more limited projections that terminate in the cerebellum, brainstem, and spinal cord. Jump up ^ Nestler, Eric J. `` BRAIN REWARD PATHWAYS ''. Icahn School of Medicine at Mount Sinai. Nestler Lab. Retrieved 16 August 2014. The dorsal raphe is the primary site of serotonergic neurons in the brain, which, like noradrenergic neurons, pervasively modulate brain function to regulate the state of activation and mood of the organism. Jump up ^ Marston OJ, Garfield AS, Heisler LK ( June 2011 ). `` Role of central serotonin and melanocortin systems in the control of energy balance ''. European Journal of Pharmacology. 660 ( 1 ) : 70 -- 79. doi : 10.1016 / j. ejphar. 2010.12. 024. PMID 21216242. Jump up ^ Malenka RC, Nestler EJ, Hyman SE ( 2009 ). `` Chapter 6 : Widely Projecting Systems : Monoamines, Acetylcholine, and Orexin ''. In Sydor A, Brown RY. Molecular Neuropharmacology : A Foundation for Clinical Neuroscience ( 2nd ed. ). New York : McGraw - Hill Medical. pp. 167 -- 175. ISBN 9780071481274. The basal forebrain cholinergic nuclei are comprised the medial septal nucleus ( Ch1 ), the vertical nucleus of the diagonal band ( Ch2 ), the horizontal limb of the diagonal band ( Ch3 ), and the nucleus basalis of Meynert ( Ch4 ). Brainstem cholinergic nuclei include the pedunculopontine nucleus ( Ch5 ), the laterodorsal tegmental nucleus ( Ch6 ), the medial habenula ( Ch7 ), and the parabigeminal nucleus ( Ch8 ). Jump up ^ `` Neuron Conversations : How Brain Cells Communicate ''. Brainfacts.org. Retrieved 2 December 2014. ^ Jump up to : Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G ( November 2008 ). `` Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum ''. Cell. 135 ( 5 ) : 825 -- 37. doi : 10.1016 / j. cell. 2008.09. 059. PMC 2614332. PMID 19041748. Jump up ^ Carlson, N.R., & Birkett, M.A. ( 2017 ). Physiology of Behavior ( 12th ed. ). 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Figure 1 : Schematic of brain CB1 expression and orexinergic neurons expressing OX1 or OX2 Figure 2 : Synaptic signaling mechanisms in cannabinoid and orexin systems Jump up ^ `` Antagonist ''. Medical definition of Antagonist. Retrieved 5 November 2014. Jump up ^ Goeders, Nick E. ( 2001 ). `` Antagonist ''. Encyclopedia of Drugs, Alcohol, and Addictive Behavior. Retrieved 2 December 2014. Jump up ^ Broadley KJ ( March 2010 ). `` The vascular effects of trace amines and amphetamines ''. Pharmacol. Ther. 125 ( 3 ) : 363 -- 375. doi : 10.1016 / j. pharmthera. 2009.11. 005. PMID 19948186. Jump up ^ Lindemann L, Hoener MC ( May 2005 ). `` A renaissance in trace amines inspired by a novel GPCR family ''. Trends Pharmacol. Sci. 26 ( 5 ) : 274 -- 281. doi : 10.1016 / j. tips. 2005.03. 007. PMID 15860375. Jump up ^ Wang X, Li J, Dong G, Yue J ( February 2014 ). `` The endogenous substrates of brain CYP2D ''. Eur. J. Pharmacol. 724 : 211 -- 218. doi : 10.1016 / j. ejphar. 2013.12. 025. 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Section 21.4 : Neurotransmitters, Synapses, and Impulse Transmission Molecular Expressions Photo Gallery : The Neurotransmitter Collection Brain Neurotransmitters Endogenous Neuroactive Extracellular Signal Transducers Neurotransmitter at the US National Library of Medicine Medical Subject Headings ( MeSH ) neuroscience for kids website brain explorer website wikibooks cellular neurobiology Neuroscience Outline of neuroscience Basic science Behavioral epigenetics Behavioral genetics Cellular neuroscience Computational neuroscience Connectomics Imaging genetics Integrative neuroscience Molecular neuroscience Neural engineering Neuroanatomy Neurochemistry Neuroendocrinology Neurogenetics Neuroinformatics Neurometrics Neuromorphology Neurophysics Neurophysiology Clinical neuroscience Behavioral neurology Clinical neurophysiology Neurocardiology Neuroepidemiology Neurogastroenterology Neuroimmunology Neurointensive care Neurology Neurooncology Neuro - ophthalmology Neuropathology Neuropharmacology Neuroprosthetics Neuropsychiatry Neuroradiology Neurorehabilitation Neurosurgery Neurotology Neurovirology Nutritional neuroscience Psychiatry Cognitive neuroscience Affective neuroscience Behavioral neuroscience Chronobiology Molecular cellular cognition Motor control Neurolinguistics Neuropsychology Sensory neuroscience Social neuroscience Systems neuroscience Interdisciplinary fields Consumer neuroscience Cultural neuroscience Educational neuroscience Evolutionary neuroscience Neuroanthropology Neurobioengineering Neurobiotics Neurocriminology Neuroeconomics Neuroepistemology Neuroesthetics Neuroethics Neuroethology Neurohistory Neurolaw Neuromarketing Neurophenomenology Neurophilosophy Neuropolitics Neurorobotics Neurotheology Paleoneurobiology Concepts Brain -- computer interface Neural development Neural network ( artificial ) Neural network ( biological ) Detection theory Intraoperative neurophysiological monitoring Neurochip Neurodegeneration Neurodevelopmental disorder Neurodiversity Neurogenesis Neuroimaging Neuroimmune system Neuromanagement Neuromodulation Neuroplasticity Neurotechnology Neurotoxin Book Category Commons Portal Wikiproject Neurotransmitters Amino acid - derived Major excitatory / inhibitory systems : Glutamate system : Agmatine Aspartic acid ( aspartate ) Cycloserine Glutamic acid ( glutamate ) Glutathione Glycine GSNO GSSG Kynurenic acid NAA NAAG Proline Serine ; GABA system : GABA GABOB GHB ; Glycine system : α - Alanine β - Alanine Glycine Hypotaurine Proline Sarcosine Serine Taurine ; GHB system : GHB T - HCA ( GHC ) Biogenic amines : Monoamines : 6 - OHM Dopamine Epinephrine ( adrenaline ) NAS ( normelatonin ) Norepinephrine ( noradrenaline ) Serotonin ( 5 - HT ) ; Trace amines : 3 - Iodothyronamine N - Methylphenethylamine N - Methyltryptamine m - Octopamine p - Octopamine Phenylethanolamine Phenethylamine Synephrine Tryptamine m - Tyramine p - Tyramine ; Others : Histamine Neuropeptides : See here instead. Lipid - derived Endocannabinoids : 2 - AG 2 - AGE ( noladin ether ) 2 - ALPI 2 - OG AA - 5 - HT Anandamide ( AEA ) DEA LPI NADA NAGly OEA Oleamide PEA RVD - Hpα SEA Virodhamine ( O - AEA ) Neurosteroids : See here instead. Nucleobase - derived Nucleosides : Adenosine system : Adenosine ADP AMP ATP Vitamin - derived Cholinergic system : Acetylcholine Miscellaneous Gasotransmitters : Carbon monoxide ( CO ) Hydrogen sulfide ( H S ) Nitric oxide ( NO ) ; Candidates : Acetaldehyde Ammonia ( NH ) Carbonyl sulfide ( COS ) Nitrous oxide ( N O ) Sulfur dioxide ( SO ) Cell signaling / Signal transduction Signaling pathways GPCR Wnt RTK TGF beta MAPK / ERK Notch JAK - STAT Akt / PKB Fas apoptosis Hippo PI3K / AKT / mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters / Neuropeptides / Neurohormones Cytokines Growth factors Signaling molecules Receptors Cell surface Intracellular Co-receptor Second messenger cAMP - dependent pathway Ca signaling Lipid signaling Assistants : Signal transducing adaptor protein Scaffold protein Transcription factors General Transcription preinitiation complex TFIID TFIIH By distance Juxtacrine Autocrine / Paracrine Endocrine Other concepts Intracrine action Neurocrine signaling Synaptic transmission Chemical synapse Neuroendocrine signaling Exocrine signalling Pheromones Mechanotransduction Phototransduction Ion channel gating Gap junction Neurotransmitter systems Acetylcholine Nucleus basalis of Meynert → Neocortex Septal nuclei ( Medial septal nucleus ) → Fornix → Hippocampus Striatum BA / M Dopaminergic pathways Mesocortical pathway : Ventral tegmental area → Prefrontal cortices Mesolimbic pathway : Ventral tegmental area → Nucleus accumbens and olfactory tubercle Nigrostriatal pathway : Substantia nigra pars compacta → Caudate nucleus and putamen Tuberoinfundibular pathway : Hypothalamus ( Infundibular nucleus ) → Pituitary gland ( Median eminence ) Norepinephrine Locus coeruleus Lateral tegmental field Serotonin pathways Raphe nuclei Anterior raphespinal tract Lateral raphespinal tract AA Aspartate Climbing fibers GABA Globus pallidus Rostromedial tegmental nucleus Glycine Renshaw cells Glutamate Thalamus Subthalamic nucleus Globus pallidus GND : 4041905 - 8 NDL : 01120489 Retrieved from `` https://en.wikipedia.org/w/index.php?title=Neurotransmitter&oldid=845208611 '' Categories : Neurotransmitters Molecular neuroscience Hidden categories : Use dmy dates from November 2014 Incomplete lists from January 2017 All articles with unsourced statements Articles with unsourced statements from November 2016 Articles with unsourced statements from December 2017 Articles to be expanded from August 2015 All articles to be expanded Articles using small message boxes Articles with unsourced statements from August 2015 All articles lacking reliable references Articles lacking reliable references from December 2017 Wikipedia articles with GND identifiers Wikipedia articles with NDL identifiers Talk Contents About Wikipedia Afrikaans Asturianu বাংলা Беларуская Беларуская ( тарашкевіца ) ‎ Български Bosanski Català Čeština Dansk Deutsch Eesti Ελληνικά Español Esperanto Euskara فارسی Français Gaeilge Galego 한국어 Հայերեն Hrvatski Bahasa Indonesia Íslenska Italiano עברית Kreyòl ayisyen Latina Latviešu Lietuvių Magyar മലയാളം Bahasa Melayu Nederlands 日本 語 Norsk Occitan Polski Português Română Русский Scots Simple English Slovenčina Slovenščina کوردی Српски / srpski Srpskohrvatski / српскохрватски Suomi Svenska Tagalog ไทย Türkçe Українська اردو Tiếng Việt 中文 50 more Edit links This page was last edited on 10 June 2018, at 05 : 56 ( UTC ). 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Question: what are the areas of the neuron that secrete neurotransmitters called
Answer: synaptic vesicles