Objective: Breast cancer is the most common malignancy in Western women. Despite the progress in morphological investigation, active research is devoted to potentially important targets for prognosis and intervention. BCL2 oncoprotein represents such factor. Method: Consecutive breast cancer cases were examined by routine protocol approach. The BCL2 oncoprotein expression was detected immunohistochemically. Expression was considered positive if it was in more than 25 % of tumour cells. The molecular subtype ( Objective: Breast cancer is the most common malignant tumour of Latvian women (www.csb.lv). Correct diagnosis, including identification of tumour histogenesis, is the prerequisite for appropriate treatment.