The heart is one of the most important targets for the actions of the ACE2/Ang-(1-7)/Mas axis. In the heart, ACE2 International Journal of Hypertension 3 is expressed in the endothelium [45] , myofibroblasts [46] , cardiomyocytes, and fibroblasts [47, 48] . Classical pharmacotherapeutic agents used to treat heart failure, including ACEi, ARBs, and aldosterone receptor blockers, increase ACE2 activity and/or expression, indicating its importance in the cardiac diseases establishment and progression [49] [50] [51] .