Scale-based analysis: In addition to visual scoring scheme, we also show the effectiveness of the proposed scale-based method on quantification of the disease extent and identification. Scale-based analysis of the regions occupied by TIB patterns is illustrated in Fig. 13 . A CT slice of a patient with HPIV shows fewer large homogeneous regions (green) with respect to a normal control. It also shows a greater number of small homogeneous regions (yellow and red). (from 1 to 10), we recorded the average number of b-scale patterns. As readily seen from both curves, the existence of TIB patterns was indicated through the small number of highly homogeneous regions (i.e., small number of large b-scale patterns) and large number of less homogeneous regions (i.e., large number of small b-scale patterns). This figure validated the qualitative Fig. 13 . The difference between two curves was at statistically significant level (p < 0.01).