Previous alcohol studies have documented that ethanol exposure decreases cAMP signaling and protein kinase A (PKA) activation [3, 21] . Ethanol also up-regulates phosphodiesterase 4 (PDE4), which increases cAMP degradation [22] #. In spite of the clear link between alcohol exposure and alteration of adenosine signaling, no published data are currently available concerning alcohol effects on airway ion transport through this signaling pathway. The current report directly measured the adenosineinduced chloride secretion of airway epithelia under the exposure of physiologically relevant concentrations of alcohol and found that ethanol attenuates epithelial CFTR-mediated chloride transport by modulating cellular cAMP levels.