We found that SOFA scores and the measurement of sRAGE levels in patients with CAP-associated sepsis helped predict survival. To date, this is the first study that analyses the levels of both of these molecules (the "HMGB-1" ligand and the "RAGE" receptor) in the inflammatory cascade of patients with CAP-associated sepsis. In Mexico, as in developed countries, CAP continues to be an important cause of death from infectious disease [1] with an elevated cost to public health. This was particularly evident with the H1N1 (2009, S-OIV) influenza virus pandemic [8] . Overall mortality is about 50% in patients with CAP that develop septic shock [25] . Although there has been intense research on the pathophysiology of CAP and its severe forms, such as ARDS, only slight improvements in new and effective treatment strategies have occurred.