Rotavirus, a dsRNA icosahedral virus in the Reoviridae family, is the leading cause of severe dehydrating diarrhea in young children worldwide, with 500,000 to 600,000 annual deaths attributed to rotavirus infections [26, 27, 28, 29] . Significant morbidity and economic impact are the main effects in the United States, accounting for approximately 50,000 to 60,000 hospitalizations a year and loss of time from work for caregivers [30] .