Seizures may evolve into status epilepticus, which can be prevented by giving large quantities of atropine early on Activity of plasma butyrylcholinesterase is more sensitive for most insecticides. Neurophysiological studies may assist in the diagnostic process. In acute organophosphate poisoning, nerve conduction velocities and distal latencies are normal, even in severely paralyzed patients [104] . The earliest and most sensitive indicator of the AChE inhibition is a small amplitude of compound muscle action potential after single supramaximal stimulation with often repetitive activity [104, 105] . On repetitive nerve stimulation, there is usually no decrement when stimulating at 3 Hz, and only occasional decrement at 10 Hz. At 30 or 50 Hz, there may be a decrement-increment response [104] in less severe stages of poisoning [105] .