Cells. Tylosema esculentum bean water and ethanolic extracts and T. esculentum tuber water extract were added on cell monolayers of CLAB, CIEB, and H4 cells at concentrations as shown in Table 2 and Figures 3 and 6 . Tylosema esculentum extracts, at the concentrations used, resulted in dose-dependent enhancement of the three types of cells. Exposure to Tylosema esculentum seed coat water and ethanolic extracts (MSCW and MSCE, resp.) generally led to enhanced survival of CLAB, CIEB, and H4 cells. This result could show that exposure to cotyledon extracts, besides the projected inhibition of RV cytopathic effects, could ensure cell survival. Figure 3 . All T. esculentum extracts, especially cotyledon ethanolic extract (MCE), led to significant protection of CIEB, CLAB, and H4 cells from cytopathic effects of rotavirus. Tylosema esculentum seed coat water extract (MSCW) offered significant protection at the lowest concentration (0.001 mg/mL), making it the most potent extract. Tylosema esculentum cotyledon water extract (MCW) also led to highly significant protection of CLAB cells. There was largely highly significant protection of H4 cells exposed to MSCE, MSCW, MTW, and MCE. Combivir (control) was shown to have highly significant protection of cells against RV. Exposure to MCE was shown to enhance survival of CIEB cells (56%) and H4 cells (275%) more than that to Combivir. On H4, there was higher protection of cells with all extracts (91%-275%) depending on concentration than Combivir alone (Figure 3 ). Some extracts, mainly seed coat and cotyledon water and ethanolic, led to higher protection at concentrations lower than the determined IC 50 .