W.H. Sha 1 , Xiaohui Zeng 1 , Yuyuan Li 1 1 GI Department, First municipal hospital of Guangzhou, Guangzhou Aim: To investigate the clinical value of serum indices for hepatic fibrosis in chronic liver diseases. Methods: Competitive radioimmunoassay was used to determine the serum level of collagen type ( C), laminin (LN) and hyaluronic acid(HA) in 193 patients with different severity degree of chronic liver diseases, and in 30 healthy subjects. Results: The serum levels of C, LN, and HA in the patients with liver diseases increased to different extent, compared with those in the healthy subjects. Of which the highest of C, LN, and HA were found in the patients with primary carcinoma of liver or hepatocirrhosis and the serum level of HA is highlight. The combination detection of serum C, LN, and HA is more valuable than single index. Conclusion: Joint detection of serum C , LN, and HA is of higher significance in clinical diagnosis and prognosis of hepatocirrhosis, and is also available for successive observation on the development of liver diseases. 