3). The contribution of the loss of these integrins and the subsequent derived impairment on cell adhesion has been reported in several tumours. Ren et al. in [598] report that ''Focal or no integrin alpha 7 eexpression in human prostate cancer and soft tissue leiomyosarcoma was associated with a reduction of metastasis-free survival (for example, for prostate cancer with focal or no expression, 5-year metastasis-free survival was 32%, 95% CI = 24.4% to 40.3%, and for prostate cancer with at least weak expression, it was 85%, 95% CI = 79% to 91%; p-value,.001)''.