JEV infection leads to increased nitric oxide (NO) production in CNS [25] . Significant two fold increases were seen in the NO levels in brain samples obtained from JEV-infected and JEV+SC-MO groups when compared to those obtained from Sham (p,0.01). NO levels subsequently got down to significantly lower levels following 39 and 59MO treatments (p,0.01) ( Figure 5F ).