The 2009 A/H1N1 influenza pandemic represents a unique opportunity to increase our understanding of the spatial-temporal diffusion patterns of pandemic influenza at different spatial scales, which is crucial for improving public health interventions against future influenza pandemics. In particular, the role of school closure and environmental forcing on the transmission dynamics of pandemic influenza remains debated [8, 9] [10, 11, 12] . Peru is a particularly interesting case study in this respect as it covers a variety of climatic zones associated with diverse influenza seasonal patterns [13] and public health authorities moved the national winter school vacation period by 2-weeks, in an attempt to mitigate the impact of the 2009 A/H1N1 pandemic. Whether the winter school vacation period had any impact on the transmission dynamics of the pandemic in Peru has yet to be evaluated, and this could provide insight into the role of school closures on control of future pandemics [8, 9, 14, 15, 16] . Here we analyze the spatial patterns of age-specific time series of influenza-like-illness (ILI) and laboratory confirmed A/H1N1 influenza cases collected in Peru during 2009. We also quantify the association between local pandemic patterns, absolute humidity, and demographic factors.