In this study, we successfully identified genetic markers in CDKN2B-AS1 strongly associated with POAG and POAG/NPG, but not with HPG, by analyzing two GWAS data sets using independent study populations totaling 2,219 Japanese subjects. For the case-control study of the Present GWAS, we excluded the samples without hesitation that didn't meet our strict quality control (see Supporting Information S1). Since we succeeded in excluding the samples possessing a fair amount of no-call or missed-call genotype data, our more stringent filters certainly improved the actual genotyping results for the association studies performed later. Thus, we were able to obtain an increased level of significance without any substructure effects of the two populations based on the definite diagnosis when combining the genotyping results of the Present and Previous GWAS data sets (Figure 3 ).