Important constituents of influenza surface membrane proteins include hemagglutinin, neuraminidase, and the matrix protein 2 (M2) proton channel [6, 7] . Hemagglutinin mediates the binding of viral particles to host cell surface sialic acid and the invasion of viruses into host cell [8] [9] [10] . Neuraminidase is responsible for the cleavage of sialic acid residues to promote the release of progeny viruses [11, 12] . M2 proton channels are critical for viral mRNA incorporation into the virion and virus budding [13] . Over one hundred serological subtypes [14] have been identified through different combinations of the 16 hemagglutinin (H1-H16) and nine neuraminidase groups (N1-N9) currently known. The 3Dstructure of M2 proton channels have recently been solved in both influenza A and B [15, 16] , allowing more in depth studies regarding its biological function and action mechanism [17] [18] [19] . These proteins have been used as targets for rational attempts to design drugs for influenza [20] [21] [22] [23] [24] [25] [26] [27] .