PLK1's Spearman correlation with the values of the Jensen-Shannon divergence of samples with the normal skin profile is relatively high (0.5863). PLK1 also has a high value of (negative) Spearman correlation with the values of the Jensen-Shannon divergence of samples with the average metastatic profile (20.44571 In the comparison, it was found that metastatic malignant melanomas with expressed PLK1 at markedly elevated levels (median, 60.00% vs. 37.98%; p-value,0.000053), concluding that PLK1 is a reliable biomarker for patients at high risk of metastases, even when the most important prognostic clinical factor (Breslow's maximum thickness of the primary malignant melanoma) indicates the contrary [147] . We consider this an important finding as PLK1 silencing is already part of an integrated oncolytic adenovirus approach currently being studied in mice models of orthotopic gastric carcinoma [148] and has promise due to the lack of a reported measurable immune response of siRNA-based therapeutics [149] . Another positive note is the less sensitivity to PLK1 depletion of cells with a functional p53 [150, 151] , and can help to sensitize cells to chemotherapy (as observed in lung cancer [152] ). This constraint of aneuploid cancer cells to PLK1 expression, particularly in cells with inactivated p53 [153] , could be exploited by lentivirus-based RNA interference [154] .