Sickle cell patients develop organ damage irrespective of their frequency of acute painful events, which has been related to significant morbidity and increased mortality, and it seems likely that SCD-related organ damage negatively impacts QoL of sickle cell patients [6] . However, to our knowledge, the impact of chronic organ damage on QoL in SCD has not been previously assessed. Therefore, we prospectively assessed the QoL in a cohort of consecutive sickle cell patients in whom chronic organ damage, pain rate, and the history of sickle cell-related complications in the last 5 years was systematically analyzed. In addition, the impact of occupation and educational level on QoL of these patients was studied.