Early studies have reported the endothelium as the major site for generation [67] and metabolism [41] of Ang- (1) (2) (3) (4) (5) (6) (7) . In addition to Ang-(1-7), endothelial cells also express ACE2 and Mas [80, 81] . Thus, now it is recognized that the ACE2/Ang-(1-7)/Mas axis is present in vascular endothelial cells and modulates its function promoting vasorelaxation [82] , reduction of the oxidative stress [83, 84] , and antiproliferative effects [85, 86] .