1. The main question is whether the complexity estimates given by the computations in this manuscript are any better than simply the number of protein-coding genes. Examining the I values for various species, from viruses to higher eukaryotes, one gets an impression that I is roughly proportional to gene numbers. Is this the case or not? If yes, what is the advantage of using I, and if no, then the relationship between the two is worth discussing in some detail.