Objective: Any disturbance of chronobiological rhytms represents a potential stressor, acting like a strong oxidant trigger. SOD family (CuZn-SOD, Mn-SOD and EC-SOD), is one of the most significant enzymatic complexes involved in antioxidant defense. Monitoring local SOD distribution in lacrimal gland after intermittent light exposure can be able to provide insights into the distinct links of antioxidant adaptative mechanisms.So long as lacrimal gland morphology and functions are dependent to a normal light exposure, mobilisation of its own antioxidant resources, especially SOD, is an usefull starting point in antioxidant ophtalmic therapy. Method: Immunohistochemistry was performed in microscopic analysis of glandular fragments prelevated from 30 male Wistar rats, randomized in control/intermittent light exposed groups for 45 days. There have been used specific antibodies for each enzymatic member of SOD family.