k 3 can be estimated as 2.5e4, which is equivalent to that human body averagely generates and deploys 4.2e7 cells at once, that is about 0.012g. The k 3 value is determined by the information structure of Schistosoma mansoni and Caenorhabditis elegans. Because C. elegans is very small and the I 3 of which is almost negligible, and Schistosoma mansoni is bigger than C. elegans but the phenotypic complexity should be a little bit less than C. elegans, therefore we adjusted the k 3 value to make the I value of Schistosoma mansoni close to, but a little bit lower than the value of C. elegans. So we take k 3 value as 2.5e4.