At the same time, D_Score also performs well for ranking the docking poses. It retrieved 20 inhibitors with Surflex_Score and 19 inhibitors with PMF_Score pose extraction. This good performance can be attributed to D_Score providing the most accurate approximation of the binding energy where both the electrostatic and hydrophobic contributions to the binding energy are counted. In addition, a distance-dependent dielectric attenuates the chargecharge, and other polar interactions were considered.