The suggested pharmacophore model Hypo1 developed so far divulges a fairly accurate idea of the required molecular features for a new lead. Therefore, Hypo1 was applied as a search query to retrieve molecules with novel and desired attributes from chemical databases (Maybridge and Chembridge). A total of 2202 hit compounds, 1478 compounds from Maybridge and 724 compounds from Chembridge, respectively, were obtained. Molecular properties were calculated for all hit compounds retrieved from databases. The 181 hit compounds (124 from Maybridge and 57 from Chembridge database, respectively) with an estimated activity value closer to the most active compound in the training set were selected for further evaluation. These hits were further filtered by using Lipinsiki's rule of five which evaluates drug-likeness, or determines if a chemical compound with a certain pharmacological or biological activity has properties that would make it feasible to be an orally active drug in humans. The 49 compounds of Chembridge database and 23 compounds from Maybridge database have satisfied the requirements of Lipinsiki's rule of five for a drug-like compound. Thus, these 72 hit compounds that satisfied the Lipinsiki's rule of five from a total of 181 hits were subjected to molecular docking.