Objective: Prostatic intraepitelial neoplasia (PIN) and atypical small acinar proliferation (ASAP) has a high predictive value as markers for prostate cancer (PCa). Method: PCa-risk in patients with precancerous lesions has been assessed on biopsy material in 172 patients having morphological suspicious to PCa. Suspicious foci were estimated with use of cocktail AMACR + HWC + p63. Results: According to our results revealing of precancerous lesions in biopsy specimens has been associated with PCa identification in re-biopsies (F=0,04). Within the first-5years the overall incidence of PCa in re-biopsies made 27 % in the group of precancerous lesions and 36 %in the ASAP group. Life-time-without-PCa median made up 5-years with no reliable difference between PIN and ASAP groups (WW=2,35; p=0,06). Thus, the cumulative share of patients without PCa in the ASAP group formed 86 %-82 %-82 %-73 %-60 % at the end of the first-second-thirdfourth-fifth year of supervision respectively. Conclusion: Within the first 5 years PCa risk makes 27 % in the general group of precancerous lesions of the prostate and 36 % in ASAP group with no difference between ASAP and PIN groups. Сumulative share of patients without PCa in rebiopsy specimens decreased from 86 % to 60 % during these 5 years.