The occurrence of symptomatic cerebral vasospasm (SCV) after aneurysmal subarachnoid haemorrhage (aSAH) is a frequent clinical condition that is unfortunately associated with worsened morbidity and mortality [43, 44] . The ability to predict patients at high risk for vasospasm would help in targeting early therapeutical efforts. So far, this has remained an unsatisfied plea [45] . In the ICU, clinical assessment by bedside evaluation is of limited usefulness due to sedation or clinical severity. Transcranial Doppler is a useful screening tool for middle cerebral artery vasospasm, with less utility in evaluating other intracranial vessels, and computed tomographic perfusion may help predict vasospasm when used early during the clinical course [46] . Due to the difficulties involved in identifying SCV, several early markers that could be used to provide therapies focused on early brain damage signs have been search for, with the aims being to prevent but also reduce the intensity of later developing neurological complications [47] . Turck [48] used an awkward panel including four brain injury-related proteins, one cardiac marker and a clinical score, and demonstrated that this is a valuable albeit complex tool for identifying aSAH patients at risk of poor outcome.