We examined hematoxylin and eosin-stained slides of 74 patients diagnosed with epithelioid mesothelioma. According to previously described predominant histological features we grouped them into six subtypes: trabecular, solid, microglandular, tubulopapillary, micropapillary and pleomorphic. Results: The median survival of all 74 patients with epithelioid mesothelioma was 14.5 months. The best median survival was in trabecular and micropapillary subtypes (each 18 months, n=20 and n=5, respectively), followed by tubulopapillary (17 months, n=18), microglandular (16 months, n=7) and solid (11 months, n=19) subtypes. The worst median survival was in pleomorphic subtype (5 months, n=5). Conclusion: Epithelioid type of diffuse malignant pleural mesothelioma shows a great diversity of histological patterns that likely have an impact on the clinical outcome and patient's survival. Further investigations of genetic variations among different subtypes may provide valuable information for better understanding of pathogenesis of these tumors. Objective: Genetic instability resulting in both aneuploidy and polyploidy are discussed to be involved in prostate cancer (PCa) development and progression. Aim of this study was to comprehensively characterize the ploidy status and proliferation levels in PCa with regard to disease progression. Method: Using FISH, we assessed 112 localized PCa, 75 PCa with 125 corresponding lymph node metastases, and 42 hormone-refractory distant metastases for losses and gains of all 24 chromosomes. The proliferation rate was assessed using pHH3 and Ki67 immunohistochemistry. Results: We observed significant increases in aneuploidy with advancing tumor stage (p<0.05). Chromosomes X, 21, Y, 14, 16, and 8 were most frequently numerically altered. Increased levels of proliferation were significantly associated with the extent of aneuploidy and tumor stage (p<0.01). Combining aneusomy of chromosomes 4, 6, 20, and X with PHH3 immunoreactivity resulted in a prediction model for lymph node metastases with a sensitivity of 73.3 % and a specificity of 72.6 %. Conclusion: We present evidence that genomic instability leading to aneuploidy is an important factor in PCa progression. Furthermore, we demonstrate that increased Ki-67 and PHH3 expression are potential indicators of metastatic disease. Lastly, we suggest a new approach to preoperatively determine lymph node metastasized disease in PCa.