Methods: We reviewed clinical features of AHA patients complicated with ARF (group A) and compared with non-complicated AHA patients (group B). Medical records of 191 patients with AHA were reviewed between January 2003 and December 2007. We experienced 11 patients (5.8%) with ARF associated AHA. Result: There were no differences between group A and group B in sex ratio and age. The peak value of ALT (median: 6133 IU/L vs 1685 IU/L, p<0.001), Alkaline phosphatase (median: 235 IU/L vs 201 IU/L, p=0.03), prothrombin time (INR, median 1.72 vs 1.09, p<0.001) was significantly higher in group A than B. Nine patients (81.8%) recovered completely with hemodialysis (6 patients, 66.7%) and only conservative management (3 patients, 33.3%), while 1 patient underwent liver transplantation and 1 patient died due to fulminant hepatic failure. There were 4 patients who underwent kidney biopsy. Two patients were diagnosed as acute tubular necrosis and 2 patient as acute interstitial nephritis and IgA nephropathy. Conclusion: AHA patients with ARF had higher ALT and more prolonged prothrombin time. The prognoses were poorer than those without ARF. However, ARF patients with nonfulminant AHA had a good prognosis with a proper treatment and should not be confused with hepatorenal syndrome. Background/Aims: To investigate the HEV infection among different animals and people with special profession, and to analyse the genotype of HEV isolated in this study. Methods: Serum and fecal samples were collected from various animals and people with special profession in the south suburbs of Beijing. HEV antigen and anti-HEV antibody were detected by DAS-ELISA. HEV RNA was extracted from fecal samples and amplified by RT-nPCR. The nucleotide sequence homology and phylogenetics of HEV strains isolated from swine were analysed. Results: The anti-HEV antibody positive rate of adult swine, cow, sheep and younger swine were 98.23% (222/226), 29.35% (54/184), 9.80% (20/204) and 60.73% (99/164), respectively. The HEV antigen positive rates of adult swine, cow, sheep and younger swine were 2.65% (6/226), 4.35% (8/184), 1.45% (3/207) and 9.75% (16/164), respectively. The HEV antigen and anti-HEV antibody positive rate of professional group was 0.40% (1/247) and 42.51% (105/247) respectively. The HEV RNA positive rate of fecal samples from younger swine was 22.89 %(19/83). 16 of 19 samples were HEV RNA positive by PCR with primers of HEV ORF1 and ORF2. The sequence analysis of the 16 samples showed that there were 2 groups designated as BJ-1 (11/16) and BJ-2 (5/16). The nucleotide homology of BJ-1 and BJ-2 was 99%. Phylogenetic analysis of HEV ORF2 indicated that both of them belonged to genotype 4d. Conclusion: Phylogenetic analysis of HEV ORF2 indicated that HEV isolated in the south suburbs of Beijing belonged to genotype 4d. 6 Bracops Hospital Brussels , 7 St. Jan Hospital, Bruges , 8 CHU Brugmann, 9 CHU Sart Tilman, Liège , 10 Gent University Hospital , 11 ZNA Middelheim, Antwerp Hepatitis Delta virus is a subviral satellite requiring hepatitis B virus to propagate, usually leading to severe, chronic liver disease. As data on epidemiology and management practice of HDV infection in Belgium are lacking, a retrospective and prospective, multi-centric questionnaire-based registry is performed in 2008. Results of 32 patients are reported. Background/ Aims: Hepatitis A is an acute infectious disease that is transmitted by fecal-oral root. Because the incidence of hepatitis A has been increased in Gwangju and Chonnam province of Korea recently, hepatitis A patients in Chonnam National University Hospital employees had been increased. So we investigated the seroprevalence of IgG anti-HAV in hospital empolyees less than 40 years old. Methods: We analysed seroprevalence of anti-HAV IgG from 1,002 hospital employees (men: 190, women: 812) . Serum ALT and bilirubin at admission were 2,979 1,711 IU/L and 3.9 2.4 mg/dL, respectively. These levels were elevated up to 3,397 1,789 IU/L and 6.8 3.7 mg/dL, respectively. ANA was positive in 81 patients (64.3%). Age, duration from peak-ALT day, duration from peak-bilirubin day, ALT level, and peak-bilirubin level were not different between ANA(-) patients and ANA(+) patients. In the while, sex, duration from symptom-onset day, and bilirubin level, and peak-ALT level were significantly different. In 51 (62%) of 81 patients with positive ANA, ANA was followed after 1 month and ANA became negative in 38 patients (74.5%). Among 13 patients with positive ANA after 1 month, titer decreased from the baseline in 7 patients, showed no interval change in 4, and increased in 2. Conclusions: Positive ANA result is not rare in patients with acute hepatitis A. It is considered that ANA transiently appear during the course of acute hepatitis A and then, disappear with the improvement of acute hepatitis. (89), 2007(107). The clinical data such as sex, admission period, AST, ALT, total bilirubin, prothrombin time, CRP, ALT normalization time did not show difference. Just WBC and GTP were higher on 2008 group. The older age patients were more on 2008 group. The patients admitted mainly on April, May, June, July (84%) on 2008 while admitted even on past years. Conclusion: Acute hepatitis A ptients is increasing. It is occurring in older age people and mainly on specific period. The more concern to prevention should be needed. Background: We analyzed the 5' non-translated region (5'NTR), non-structural proteins 2B and 2C of hepatitis A virus (HAV) genome, whose mutations have previously been shown to be important for enhanced replication in cell culture systems, in order to align all of our data and examine whether genomic differences in HAV are responsible for the range of clinical severities. Methods: Our accumulated HAV strains of 5'NTR (nt 200 and 500), entire 2B and 2C from 25 Japanese patients with sporadic hepatitis A, consisting of 7 patients with fulminant hepatitis (FH), 5 with severe acute hepatitis (AHs), and 13 with self-limited acute hepatitis (AH), in whom the sequences of all 3 regions were available, were subjected to phylogenetic analysis. Results: FH patients had fewer nucleotide substitutions in 5'NTR, had a tendency to have more amino acid (aa) substitutions in 2B, and had fewer aa substitutions in 2C, than AH patients. Four FH and 2 AHs with higher viral replication were located in the near parts of the phylogenetic trees, indicating the association between the severity of hepatitis A and genomic variations in 5'NTR, 2B and 2C of HAV. Conclusions: Our study suggests that genetic variations in some parts of HAV might cooperatively influence replication of the virus, and thereby affect virulence. Viral factors should be considered and examined when discussing the mechanisms responsible for the severity of hepatitis A. Aims: The incidence of acute viral hepatitis A in adults is increasing very much in South Korea, 2008. The aim of this study was to the clinical features and course in Daejoen and its surrounding area. Methods: Forty seven patients admitted as acute viral hepatitis A in Chungnam national university hospital between January 2008 and June 2008 were enrolled. The medical records were reviewed, retrospectively. Results: The mean age was 30.5. Common occupations were company employee and studuents. Most common symptom was jaundice. Presumptive infection sources were raw fish or shellfish and raw meat. Initial laboratory findings were as follows(mean value): WBC 6126/uL, Hemoglobin 13.4g/dL, Platelet 212×10 3 /L, AST 2268IU/L, ALT 2755IU/L, total bilirubin 5.2mg/dL, alkaline phosphatase 207U/L, GGT 379U/L, prothrombin time(INR) 1.2. Hospitalization was 21.5days. Peak laboratory findings were as follows: ALT 3181IU/L, total bilirubin 8.8mg/dL. Leukopenia (<4000/uL) and thrombocjtopenia (<10×10 5 /L) were ocurred in sixteen and six patients, respectively. Recovery time of each biochemical finding was as follows: ALT 20.2 days, total bilirubin 26 days. Recovery rates of ALTand total bilirubin were 74.4% and 74%, 88.5% and 92% at 4 weeks, 8 weeks after diagnosis, respectively. Prolonged jaundice (115days) was detected in one patient. All patients were recovered by supportive management. Conclusions: In South Korea, acute viral hepatitis A was more prevalent in young adults, recenlty. Presumptive infectious sources were raw fish or 1 Guangxi Center for Disease Prevention and Control shellfsh and raw meat. If it can not change the food style that many Korean enjoy raw seafood, vaccination for adults must be considered to prevent it.