Patients and Methods: To analyze BMD we divided 117 patients basing on diet-therapy and diet-adherence; to analyze 12-months calcium integration we considered 29 patients on diet; to analyze physical activity we divided 117 patients basing on diet-therapy, calcium integration and physical activity. DEXA measured L1-L4 mineralization; we reported body mass index, Zscore-BMI, serum Calcium, Phosphate, Magnesium, Alkaline Phosphatase and Phenylalanine. Results: Zscore-BMD was statistically different between patients on diet and on free-diet, higher in the group with good adherence to diet than in the group with poor adherence. Zscore-BMD and serum Phe did not correlate proportionally. Zscore-BMD and blood-parameters improved after calcium integration. There was no significant difference between patients on diet with both calcium integration and physical activity versus patients on free-diet and physical activity.