There is scant information on the proportion of transmission that occurs in different social contexts. The best data available only allow the proportion of transmission in households to be quantified [7] , [8] . Therefore, while models can give some insight into the likely benefit of single or combined interventions, that insight is somewhat limited by this lack of data. To some extent, the results depend on the assumptions made by the modelers about transmission in the different contexts. The degree of uncertainty does depend on the specific control measures. Modelers can arguably better project the possible effects of antiviral and vaccine use, case isolation, and household quarantine than the effects of school closure, mask use, banning of mass-gatherings, or nonspecific social distancing measures.