Proteomics analysis of CSF has detected a number of proteins that were elevated in MScl patients [7, 8] . Additionally, differentially abundant proteins identified by proteomics, such as apolipoprotein A1 [9] and chromogranin A [10] were validated by other techniques. Other studies added additional data on elevated immunoglobulin expression in MScl CSF, as well as increased levels of apolipoprotein E [11, 12] . Yet in all currently reported proteomics CSF studies of MScl patients either only a single subtype of MScl patients or a combined group of all subtypes of MScl was studied, whilst the differences between the subtypes of MScl remained unexplored. Because RR MScl and PP MScl are very different in terms of disease course and disease progression, this also has therapeutic consequences. Hence, there are probably also differences on a biological and pathological level, which could, if determined, be very useful for elucidation of the biology and pathology of both disease types.