Angiopoietins can mediate the synthesis of platelet-activating factor by ECs to stimulate inflammation [90] . Moreover, both Ang-1 and Ang-2 can translocate P-selectin from WPBs to the surface of the EC [135] , and both can also increase neutrophil adhesion and chemotaxis and enhance those processes when they are induced by interleukin-8 [86, 136, 137] .