Influenza is a serious disease that seasonality causes substantial but varying morbidity and mortality. In Taiwan, estimates of the influenza mortality burden were based on post-hocanalyses of national mortality statistics and not available until at least six months after the corresponding epidemic. Timely monitoring and early detection of influenza-associated excess mortality can guide antiviral or vaccine interventions and help healthcare capacity planning. Beginning April 2009, Taiwan Centers for Disease Control (TCDC) has been collaborating with the Department of Health (DOH) Office of Statistics to develop an automated system for real-time P&I mortality surveillance (1).