Previously, preliminary and potentially subjective notes made by physicians upon first contact with ill individuals had been used for an approximate determination of the clinical impact of HRV-QPM [31] . To better address clinical impact, a comprehensive review of available patient charts was undertaken and two objective severity scoring tools were applied (Table 1) . Most HRV-QPM-positive individuals (76.5%) were admitted to hospital ( Table 2 ). Five patients were admitted for 96 hours or longer; two with severe illness and only HRV-QPM detected (variants 005 and 012) and one with moderate illness positive for HRV-QPM (variant 017) and HCoV-NL63. The remaining two had underlying medical conditions and multiple infections (HRV-QPM variant 009 and HCoV-229E with cystic fibrosis deterioration and HRV-QPM variant 008, HBoV and HCoV-NL63 with a viral URTI during admission for cardiac surgery). Oxygen therapy was required by almost half of all HRV-QPM-positive individuals studied. In addition to those described previously [31] , a new co-detection was identified with the newly identified polyomavirus, WUPyV [41] in a patient exhibiting a persistent cough, already positive for HRV-QPM (variant 013) and HBoV.