For the pose ranking, it appears that the ranking by Ludi_1 retrieved more actives than the other scoring functions. Ludi_1 retrieved 20 inhibitors with D_Score and ChemScore pose extraction and 18 inhibitors with Surflex_Score and G_Score pose extraction. Ludi_1 was derived by empirically fitting a set of protein-ligand complexes with experimentally measured binding affinities. It is a sum of the five contributions including hydrogen bonds, perturbed ionic interactions, lipophilic interactions, the freezing of internal degrees of freedom of the ligand, and the loss of translational and rotational entropy of the ligand.