The principle of antidotes is to reverse the effects of excess acetylcholine by inhibiting cholinergic effects and by reactivating the enzyme. Atropine may help to reverse bronchial constriction, which is given a starting dose of 2 to 6 mg followed by 2 mg every 5 to 10 minutes until the secretions halt and ventilation is improved. High cumulative doses (10-20 mg) in the first hours are not uncommon. Monitoring for atropine toxicity (delirium, hyperthermia, increased fasciculations) is necessary. Atropine may also cause arrhythmias and may even result in ventricular fibrillation if given intravenously in the presence of hypoxia. Electrocardiographic changes (ST depression and T-wave flattening) and cardiac arrhythmias reflect atropine toxicity and may be treated with propranolol. The combination of atropine with benactyzine is believed to be more effective, presumably by increasing central anticholinergic activity [5] .