The reported predictions may enable pharmacologically important downstream research. For example the predicted sites can be used as a starting point for quantifying in vivo effect on downstream transcription; for identifying the TFs bound; and even for the more complex task of understanding the role of each site in determining the relative abundance of GABA A receptor isoforms. Research along these lines may dramatically improve our understanding of GABA A receptor regulation and its role in disease and development. Additionally, a more comprehensive evaluation of the remaining GABA A receptor subunit genes may reveal additional TFbinding sites that uncover the evolutionary significance of g-a-b GABR clusters in the human genome.