A surveillance system using syndromic and CSTE case definitions allows for comparison of morbidity in the United States/ Mexico border region, increased communication and bidirectional sharing of information across the border. Creating and expanding a regional surveillance system that crosses an international boundary requires coordination and collaboration from all agencies involved. These surveillance data allow for examination of the border region as one epidemiologic unit. Consistent communication with clinicians and hospital staff helps to build credibility and interest. Simplicity in surveillance procedures encourages compliance. These surveillance efforts can guide vaccine allocation planning and efficiency in evaluating illnesses that maybe vaccine preventable. Systems to share information between various states in the United StatesÁMexico border region are important to develop binational control strategies.