In 1994, the Histocyte Society conducted the first international treatment study for patients with HLH and they recommended treatment with etoposide 150 mg/2 M twice a week for two weeks, dexamethasone 10 mg/2 M also for two weeks, cyclosporine 3 mg/kg to 5 mg/kg for a long period and metotrexate in cases where the patient's nervous system is already affected. In resistant cases, several modes of therapy were described including high dose steroids, cyclosporine, antihuman thymocyte globulin (ATG), intravenous immune globulin (IVIG), plasma exchange and allogeneic bone marrow transplantation [14] . Recently, IL-1 beta receptor antagonist (Anakinra) was used with success in severe cases of HLH [15] .