If palmitoylation can regulate phosphorylation, can phosphorylation regulate palmitoylation? The STREX variant of BK potassium channels contains a PKA phosphorylation site within the cytoplasmic C-terminal tail that mediates channel inhibition (Tian et al., 2001) . A recent study reported that the STREX variant also contains palmitoylated cysteines adjacent to the PKA If depalmitoylation is not restricted to a specific membrane compartment, this suggests (a) a common depalmitoylase with access to many membranes (consistent with the cytosolic localization of Apt1), (b) a group of depalmitoylating enzymes with wide membrane compartment coverage, or (c) nonenzymatic depalmitoylation.