On the average, hepatitis C virus infects 1.2% of the population worldwide. In Egypt, the prevalence rates reach 20% in some areas. Ability of the virus to persist in about 75-85% of infected individuals is related to the virus higher mutation rate. Six major HCV genotypes have been identified. Genotype 4 seems to be confined to the Middle East and Central Africa. Extra hepatic syndromes have been reported in up to 1/3 of HCV patients. We aim in this study to determine the relationship between viral genotypes and specific extra hepatic haematological disease in patients with chronic hepatitis C. The study group included 60 selected patients with chronic hepatitis C having various haematological problems. We studied hepatitis C virus genotypes using RT-PCR. We found among 60 patients , 57 genotype 4 (95%) and 3 patients genotype 1a (5%).28 patients (46.66%) were diagnosed as chronic hepatitis C with associated thrombocytopenia, 16 patients (26.66%) were diagnosed Mixed Essential Cryoglobulinemia(MEC), 13 patients (21.66%) were diagnosed Non-Hodgkin's lymphoma, and 3 patients (5%) were Aplastic anemia. Positive serum cryoglobulins level was found in 20 patients (33.3%).No significant correlation was found between the level of viraemia and specific haematologic disease, biochemical liver markers or liver enzymes (P>0. 05). We did not find correlation between HCV genotype and specific extrahepatic haemological disorder in HCV infected patients. Several environmental, genetic and immunological factors may contribute in disease progression. Results: In the targeted area 111 shops of barbers were successfully interviewed and total 715 questionnaires were filled by both groups. The mean age were found in both groups of Barbers (n=186) and Clients (n=529), 28.47 years. The both groups showed that there are no any drugs which can protect us from diseases. Both of the groups were not vaccinated for hepatitis B diseases. Regarding the care providers the barbers replied that they prefer registered medical practitioners and the clients generally prefer the Hakeems. Those who knew Hepatitis as liver disease, were 73 (39.2%), out of 186 barbers only 68 ( 36.6%) were knowing about Hepatitis-B&C, When we enquired about routes of HBV& HCV transmission only (37%) replied correct routes of transmission in both groups. About HBV vaccination (49.7%) were aware, only (14.8%) were vaccinated against HBV. 60% barbers claimed for disinfection of instruments before shaving (88.9%) claimed for use of new blades. In the sero-surveillance the HBV found was very low and HCV became epidemic (5.7% -14.4 %) respectively. Conclusion: The both groups need awareness for transmission. The use of new blade for the clients reduces the burden of HBV and HCV. The study highlights the roles of male sex, older age, and genotype 1b in the progression from CHC infection to HCC. Patients with higher HCV viral load potentially tend to develop HCC; however, HCC occurrence could be prevented using antiviral treatment. These two points need to be clarified further by a larger study population with longer follow-up period. An approach have recently been described that retroviral vectors encoding T cell receptor (TCR) genes are used to redirect the specificity of normal peripheral blood lymphocyte (PBL)-derived T cells to recognize the tumor antigens. The therapy in which T cells have been genetically modified with TCR genes to recognize HCV would represent a novel approach for the treatment of HCV infections and HCV-related malignancies. We have previously shown that HCV+ liver transplant patients that have received HLA disparate liver allografts have HCV reactive T cells of host origin in their peripheral blood that are restricted by the donor HLA molecules. Initial studies indicate that the TCRs expressed by HCV reactive T cell clones from these patients have relatively high affinity for their ligands. We have cloned and expressed two TCRs which mediate recognition of the 1406-1415 and 1073-1081 epitopes from the HCV NS3 protein. The results indicate that these TCR transduced T cells can recognize the wild type epitopes, as well naturally occurring mutant variants of these epitopes. Most importantly, the TCR transduced T cells could also recognize HCV+ hepatocellular carcinoma cells. These data suggest this high affinity HCV-specific TCR might have potential new immunotherapeutic implications. Background: Factors associated with SVR in patients without an RVR remains unclear. Methods: 200 HCV-1 (100 for 24 and 48 weeks, separately) and 150 HCV-2 (100 for 24 weeks, 50 for 16 weeks) patients were randomized to peginterferon-alpha-2a and ribavirin for analysis. Results: Multivariate analysis showed that treatment duration and a complete EVR were the strongest independent factors associated with an SVR. A higher SVR rate and a lower relapse rate were observed in the standard regimen group than in the abbreviated group in patients who had a cEVR (table 1). The best levels of viral loads in predicting cEVR at week 4 were < 10 4 IU/mL (table 2) . Conclusion: It was crucial to achieve a cEVR with adequate treatment duration in patients who failed to achieve an RVR. 