Results: MUC1 was the only mucin significantly expressed in most of all cases (88 %), being present within ductal lumen and cytoplasm. The other mucins showed a focal positivity in few cases, where MUC 2, 5 AC and 6 were cytoplasmic, while MUC4 was expressed in ductal lumen and blood vessels. Objective: Drug resistance remains a major problem in the treatment of NSCLC cancer patients for both, conventional chemotherapeutic and novel biological agents. Intrinsic or acquired resistance is caused by a variety of mechanisms, including increased drug elimination, decreased drug uptake, drug inactivation and alterations of drug targets. Recent data showed that drug resistance mechanisms might also be regulated by microRNAs (miRNAs). Method: We tested 65 lung cancer samples. The total RNA was isolated from individual specimens and then RT-PCR and pre-amplification were performed. We detected levels of miR-21, miR-23a, miR-23b, miR-126, miR-205, miR-335*, miR-3163, miR-491-3p, miR-548p, miR-548x, miR-576-5p, miR-590p, miR-655, miR-656 and miR-944 using Taq-Man® MicroRNA Assays by LightCycler® 480 Real-Time PCR System. We assigned obtained results using statistical methods.