Most Cambodians live in rural areas and raise animals for consumption (2) , typically keeping poultry, swine, or cattle close to the home. Because H5N1 infection has been associated with exposure to infected poultry (5-10) and little is understood of the perceptions of rural farmers regarding AI (11), we conducted a knowledge, attitude, and practices survey of poultry handling in rural Cambodia to estimate the extent of interactions between humans and poultry, to understand practices in poultry handling among villagers, and to develop interventions designed to increase reports of poultry deaths and safe poultry handling.