The Ethanolic Extract of Fructus Schisandrae Chinensis Decreased Hepatic Triglyceride Level in Mice Fed with a High Fat/Cholesterol Diet Results At week 8, fibrosing NASH models showed severe hepatic steatosis, infiltration of inflammation and fibrosis, which is associated with down-regulated MMP-2/9 mRNA and protein, up-regulated TIMP-1/2 mRNA and protein. Rosiglitazone significantly reduced MCD-induced fibrosis by induced MMP-2/9 expression and reduced TIMP-1/2 expression by activating PPAR .