Results: In diabetic mice, the healing process was slower, showing an engulfment of acute inflammatory cells that triggered macrophage activity when compared with controls. At day 3, MPC treatment leaded to a faster healing with retraction of the wound site, NT induced a slower noncontracting healing and combined application delayed inflammatory repair with persistent neutrophils. Conclusion: At day 10, all treatments induced a total healing however, MPC + NT reduced neutrophils infiltration compared with MPC alone.