Objective: Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue sarcoma of the skin characterized by the presence of specific COL1A1-PDGFB fusion protein, which appears as a consequence of the t(17;22) (q22;q13) translocation. Method: The aim of the study was to perform an analysis of patients with advanced DFSP treated with imatinib, with or without surgery. We examined 15 patients (6 male, 9 female; median age 56 years) with locally advanced/initially inoperable and/or metastatic DFSP treated with imatinib 400-800 mg daily between 12/2004 and 06/2009. All diagnoses were ascertained cytogenetically (fluorescent in situ hybridization). Median follow-up time was 16 months (range: 4-81). Results: Metastases were present in 8 cases (two lungs, two soft tissue, two lymph nodes). Fibrosarcomatous transformation was confirmed in 7 patients. After treatment with imatinib overall responses were: 10 partial responses, 2 stable diseases (13 %) and 3 progressive diseases (20 %). Seven patients (47 %) after resection had residual disease confirmed by pathologic examination and remained free of disease. Conclusion: We proved that anti-tumour effect of imatinib in DFSP with presence t(17;22) had in most cases good responses. Imatinib therapy may in some cases leads to tumour resection because of lesser size. Objective: At an estimated incidence of 2 cases per million per year, osteosarcoma is the most common malignant primary bone tumor. Method: We conducted a retrospective study to identify the osteosarcoma cases diagnosed at major tertiary care hospitals in Turkey. Results: Our study group was made up of 745 cases: 440 men, 305 women, aged 3-82 years (mean 23.7 year). All patients had been diagnosed with skeletal osteosarcoma between 2001 and 2011 at one of the 10 tertiary care referral center. Tumor was most frequently located in femur (50.4 %) followed by tibia. Apart from the long bones, pelvic and gnatic bones were the next in location, 4.4 % and 1.6 % respectively. There were 16 (2.1 %) secondary osteosarcomas, related to previous irradiation and various underlying diseases. For the histological types conventional osteblastic intramedullary tumors were most prevalent, making 71.8.% of the cases. Chondroblastic and telengiectatic osteosarcoma are the next common histologic types. Surface tumors were detected in 51 (6.8 %) cases. Rare histological types like small cell, epitheloid, chondroblastoma like and fibrous dysplasia like were also reported. Conclusion: This study is conducted as a preliminary work to form the basis of a pathologic database for the osteosarcoma cases diagnosed in our country. Objective: Kaposi's sarcoma is a rare disease likely associated with human herpes virus 8 infection, and occurs predominantly in Jewish, Mediterranean and middle eastern men. Since there is a paucity of reports on the pattern of its occurrence in Tunisia, we here analysed the epidemiological pattern and anatomoclinical features. Method: We retrospectively studied 71 consecutive cases of Kaposi's sarcoma diagnosed in the Pathology Department, Farhet Hached Hospital, Sousse during a 15-year period.