The desmoglein-specific cytoplasmic region (DSCR) is the site of caspase cleavage during apopotosis and is a conserved region of yet undefined function and unknown structure, but it specifies the function of the desmoglein family of cell adhesion molecules (of which DSG 1 is a member). It has been recently shown that the DSCR has a weak interaction with PKP1, Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) and the cytoplasmic domain of Desmocollin 1 [181] . Plakoglobin is cleaved by Caspase 3 during apoptosis [182] . In addition, Kami et al. in Ref [181] also report and conclude that: ''desmoglein 1 membrane proximal region also interacts with all four DSCR ligands, strongly with plakoglobin and plakophilin and more weakly with desmoplakin and desmocollin 1. Thus, the DSCR is an intrinsically disordered functional domain with an inducible structure that, along with the membrane proximal region, forms a flexible scaffold for cytoplasmic assembly at the desmosome''.