The inherent problems with analyzing and applying data generated from global expression profiling stems from the obvious difference in epilepsy models, the profiling platform used, animal type and laboratory environment. Care must be taken in comparing genomic profiles generated from differing epilepsy models. Genomic reactions are clearly different between different species of the same animal (86) . These differences must be accentuated even more when comparing the different profiles in mice, rats and humans. Status epilepticus models of epileptogenesis possess the advantage of a clear-cut progression from initial insult to chronic epilepsy in contrast to electrical kindling where a predominantly time-dependent protocol is usually administered. The rapid electrical amygdala kindling model utilized in our laboratory allowed the effects of seizures in isolation to be investigated without the confounding effects of neuronal loss. In contrast, status epilepticus models of epileptogenesis demonstrate marked neuropathological changes and may manifest widespread systemic effects. The use of benzodiazepines to halt prolonged severe status epilepticus in these models may also adversely alter the transcriptome.