TP63. The product of this gene [111, 112] belongs to the same protein family of its more famous relative, TP53, a gene that is often mutated in human cancers [113] and highly regarded as a key ''tumor suppressor''. TP63's product, p63, is a homologous protein to p53, which is considered to be phylogenetically newer [114] and also regarded as an important apoptotic and cell-cycle arrest protein. Mice that lack TP53 are born alive with a propensity for developing tumours; mice that lack TP63 do not appear to be tumour prone, although, new results are partially contradicting earlier findings [115] . It appears that the diverse roles of the isoforms of the p63 family reveal that there exists a crosstalk with the different isoforms of the p53 family that needs to be systematically investigated [116] . It has recently been shown that p63 is a key regulator of the development of stratified epithelial tissues [113] and that its deletion results in loss of stratified epithelial and of all keratinocytes [117] . Melanocytes also express two isoforms of p63 [118] , but p63 expression is not reported in 57 out of 59 tumors in a tissue microarray study performed by Brinck et al. [119] . It is clear that the the role of loss of expression of TP63 in melanoma warrants further investigation.