We introduce the following general terminology and notation: The optimization criterion (objective function) of the model incorporates measures of expected societal and economic costs of the pandemic: the societal cost includes the cost of lost lifetime productivity of the deceased; the economic cost includes the cost of medical expenses of the recovered and deceased and the cost of lost productivity of the quarantined. To compute these costs, the following impact measures of morbidity, mortality, and quarantine are used, for each region k: To estimate these measures, we use the following regression models obtained using a single-region simulation of each region k: