Results: Results showed a positive correlation between HURP overexpression and grade as well as lymphovascular invasion. All non malignant biopsies were negative. Furthermore, positive expression of HURP appeared to be an important independent prognostic factor too, related with poor survival rates. Conclusion: Our results showed that HURP overexpression is associated with poor prognosis in pancreatic adenocarcinoma and indicated a diagnostic potential of this protein. Its role in the carcinogenetic process awaits further elucidation.