Considering that different cytokines act in the immunological network as stimulating/up regulating factors and also in a feedback loop as down regulators, the cytokine balance might play a role in the immune response outcome. Therefore we calculated MIP-1β/IFN-γ ratios for every patient and compared those from mild dengue with those from severe dengue. Ratio averages ± SEM were respectively 3032 ± 514 and 864 ± 240 (P = 0.0003; Mann Whitney U test), confirming our earlier data that these cytokines are acting as opposing factors. The different models built here using clinical manifestations as independent variables each exhibit specific cytokine profiles.