A review of studies by Berghmans et al [82] revealed that cisplatin was the most effective single agent for mesothelioma, with carboplatin having similar activity, and in combination with doxorubicin provided a response rate superior to other regimens studied, although there was no clear benefit in terms of survival. Single agent vinorelbine and combination treatment MVP (mitomycin C, vinblas-tine and cisplatin) have also been shown to provide good symptom relief with acceptable toxicity [83] [84] [85] .