Epigrass is a platform for network epidemiological simulation and analysis. It enables researchers to perform comprehensive spatio-temporal simulations incorporating epidemiological data and models for disease transmission and control in order to create complex scenario analyses. Epigrass is designed towards facilitating the construction and simulation of large scale metapopulational models. Each component population of such a metapopulational model is assumed to be connected through a contact network which determines migration flows between populations. This connectivity model can be easily adapted to represent any type of adjacency structure.