Expressions of c-erb-B2, EGFR, p27, PTEN, mTOR, PI3K in hepatocellular carcinomas and adjacent liver tissues Method: Fifty HCC cases were stained immunohistochemically with these markers. Correlations between the markers and pathologic characteristics were analyzed. Results: The cases had an average age of 56,72. Male/female ratio was 44/6. HBV is more common in advanced stages and right lobe location (p<0.05). Tumor size is significantly larger in patients older than 50 years (p<0,04). No membranous c erb B2 staining was seen while cytoplasmic positivity was present in 92 % and significant correlation was found with multiplicity (p<0.041) and p27 positivity (p<0,011). EGFR membranous positivity was present in 90 % and significantly correlated with stage (p<0.05). p27 was negative in 92 % and PTEN is reduced or absent in 56 %. All markers were similarly expressed in adjacent noncancerous tissue. No significant correlations were found between PTEN, mTOR, PI3K and the pathological parameters. Conclusion: In our study, as a first step, none of the markers among c-erb-B2, EGFR, p27, PTEN, mTOR, PI3K was found significant in correlation with pathologic features. We look forward to obtain further results in the next study consisting of correlations with follow ups.