In the GLEaMviz tool the setup of the simulations is highly flexible in that the user can design arbitrary disease compartmental models, thus allowing an extensive range of human-to-human infectious diseases and intervention strategies to be considered. The user interface has been designed in order to easily define both features specific to each compartment, such as the mobility of classes of individuals, and general environmental effects, such as seasonality for diseases like influenza. In addition, the user can define the initial settings that characterize the initial geographical and temporal conditions, the immunity profile of the population, and other parameters including but not limited to: the definition of an outbreak condition in a given country; the number of stochastic runs to be performed; and the total duration of each simulation. The tool allows the production of global spreading scenarios with geographical high resolution by just interacting with the graphic user interface. While an expert input would be required to interpret and discuss the results obtained with the software, the present computational platform facilitates the generation and analysis of scenarios from intensive data-driven simulations. The tool can be deployed both in training activities as well as to facilitate the use of large-scale computational modeling of infectious diseases in the discussion between modelers and public health stakeholders.