only 32% reported eating fast food one or more times a week. More than half of the youth (50.6%) had at least 20 minutes of exercise less than 3 days a week. While a third of the group (33%/ 30 pts) walked briskly for at least 10 minutes daily. On the other hand, almost all participants reported eating candy, chips or cookies "some days" (52.7%) or "every day" (41.8%). Similarly, 73.7 % had less than 4 days of exercise in the prior month and 43% received less than the recommended amount of sleep. Health protective behaviors are an important aspect of managing care for urban YPLH. Introduction: The worldwide scale-up of antiretroviral treatment (ART) in recent years (>4 million under treatment in 2009) occurred against a backdrop of strong economic growth. Still, 5 million people needing ART remain uncovered. Further, this progress is threatened by the global financial crisis making it urgent to estimate how funding changes will affect ART programs. Methods: We quantify the impact of ART funding changes by modeling their effect on ART coverage and incorporating feedback from coverage to mortality, and from coverage to HIV incidence using a behavioral sub-model. We analyze the changes in ART coverage, HIV incidence, and mortality for several funding scenarios to make concrete policy recommendations. We apply our model to South Africa (SA) using published estimates of current ART coverage, ART effectiveness, HIV incidence, HIV prevalence, HIV transmission probabilities and the annual number of sexual partners. Results: Universal ART coverage (UC) can be achieved in SA within a few years if funding increases every year at the rate it increased from 2007-08. In contrast, only maintaining current funding levels will result in declining coverage. Surprisingly, even a 1/3rd funding decrease over 3 years followed by increases at the 2007-08 rate delays achieving UC by 10 years. Increased prevention effectiveness can substantially reduce time to achieving UC. In contrast, increases in the CD4 count threshold for treatment eligibility could make UC very hard to achieve. Discussion: Only continued increases in ART funding in coming years can ensure that ART coverage levels can be increased in the future. Policy choices, such as investment in prevention and ART eligibility criteria, will be crucial in ensuring the future success of the ART roll-out. Purpose: A cancer diagnosis often involves distress which may in the long term develop into clinical depression. Screening instruments identifying highly distressed patients are needed. In Denmark, no validated instrument has been developed to identify cancer patients in need of psychosocial support. We are thus examining the psychometric properties of a Danish version of the single-item Distress Thermometer. Methods: A total of 434 women newly diagnosed with breast cancer (within 1-2 days) were invited to participate in this study. A total of 362 accepted (83%). The accuracy of the single item Distress Thermometer is compared to the longer validated scales of Hospital Anxiety and Depression Scale (HADS) and Impact of Event Scale (IES) using Receiver Operating Characteristic curve analyses. Results: Preliminary results show that 72% are distressed according to a cut-score of ≥4 on the Distress Thermometer (11-point scale, 0-10) with a mean of 5.4 and a standard deviation of 3.1. We plan to present results on the accuracy of the Distress Thermometer compared to the HADS and IES. Psychometric properties including sensitivity, specificity, positive and negative predictive value of the Distress Thermometer will be presented. Also, a cut-point for clinical use will be discussed. Conclusion: We expect that the psychometric properties of the Distress Thermometer will be satisfactory and that we will be able to determine an optimal cut-point. The results will be important for improved handling of psychosocial problems among breast cancer patients in Denmark. By targeting psychosocial support and rehabilitation to those who are most distressed we may be able to tailor the support and hence prevent that some patients develop clinical depression. BACKGROUND: Treatment-related pain is an important issue in breast cancer rehabilitation. As most studies in the area are crosssectional, relatively little is known about possible predictors. AIM: To explore the prevalence of pain and the role of depression as predictor in a nationwide prospective study of women treated for breast cancer. METHODS: The study cohort consisted of 3343 Danish women (aged 26-70) treated for primary breast cancer according to standardized guidelines. A questionnaire package including Beck's Depression Inventory was mailed out 3-(baseline) and 15-months post-surgery (follow-up). The response rate at follow-up was 94%. Probable cases of major depression (MD) were identified according to the manual (cutoff>=17). Frequency and severity of treatment-related pain in breast and arm or shoulder was assessed by 4 items at follow-up (range: "no pain" to "all the time" and "no pain" to "extremely severe"). DBCG and the surgical departments provided data on eligibility, clinical variables and comorbidity. Data on psychiatric history, demographic-, and socioeconomic factors were obtained from national registries. RESULTS: At follow-up, 73% reported pain during the recent month and 33% had pain "almost every day" or more often. Twenty-eight percent were "somewhat" or more affected by pain and 11% were "very" or "extremely" affected. Women with MD at baseline were more likely to experience pain "almost every day" or more often at follow-up (OR=2.63; (95% CI, 2.12-3.27)) and more likely to be affected "somewhat" or more by pain (OR=3.49; (95% CI, 2.80-4.35)). When adjusted for potential confounders (demographic-, socio-economic-, clinical-, health status-, and health behavior variables), the predictive power of MD persisted (OR=1.93; (95% CI, 1.50-2.48), and OR=2.31; (95% CI, 1.79-2.99)). CONCLUSION: The prevalence of treatment-related pain was substantial with nearly 3 out of 4 experiencing pain 15 months post-surgery and 1 out of 9 reporting to be very or extremely affected. Depression was found to be an important independent predictor of pain. AIM: Relative to other oncology populations, the brain tumor (BT) population is unique given that both benign and malignant BTs can be life-threatening and can cause severe neurocognitive and psychosocial disturbances. No study to date however, has investigated the effects of BT-related posttraumatic stress (PTSS) on neurocognitive functioning and overall quality of life in adult BT patients. The aim of the present study was to address this question. METHOD: Utilizing a longitudinal design, adult individuals diagnosed with a primary BT were assessed on average, within 6-weeks prior to starting radiotherapy (T1), and re-assessed at 3 months post-radiotherapy (T2). At both assessments, participants were administered a standardized battery of tests measuring BT-related PTSS, mood, quality of life, memory and executive functioning. RESULTS: To date, 64 patients (36 females, 28 males) have been re-assessed at T2. At both T1 and T2, 14% of the sample reported clinically elevated levels of PTSS pertaining to their BT experience; although, the effects of PTSS fluctuated over time. Whereas 40% of individuals who reported elevated PTSS prior to commencing radiotherapy continued to report elevated PTSS at T2, 60% of patients with elevated PTSS at T2 did not experience elevated PTSS at T1. Prior to radiotherapy (T1), individuals with elevated PTSS were found to have significantly reduced functional well-being, elevated BT symptoms and social constraints, as well as heightened depressive, anger, fatigue and confusion symptoms (p's<.05) compared to patients with low PTSS at T1. Individuals with elevated PTSS also evidenced significantly reduced scores on working memory and executive tests (p's<.05) compared to individuals with low PTSS at T1. Similarly, individuals with elevated PTSS at T2 reported significantly reduced functional well being, vigor, and overall quality of life, as well as elevated BT symptoms, depression, anger, confusion, and social constraints (p's<.05) compared to individuals with low PTSS, 3-months post-radiotherapy. Individuals with high PTSS at T2 also performed significantly worse on working memory and executive tests (p's<.05). DISCUSSION: