The fi nding of SAFV in invasively collected samples from the 2 children described here fi ts well with the knowledge about the picornavirus group. SAFV probably behaves similarly to the viruses in the enterovirus group, producing mainly asymptomatic infections but also producing nonspecifi c symptoms in other patients and severe disease in a few patients. Enteroviruses are known to cause many more or less organ-specifi c diseases such central nervous system infection (meningitis, encephalitis, and myelitis), myocarditis, enanthema, exanthema, and septicemia. These 2 cases fi t well within the expected range of diseases attributed to picornaviruses, but further studies are needed to determine the exact correlation of SAFV to disease in humans.