Foot-and-mouth disease virus (FMDV) was the first recognized viral pathogen [40] and is the sole member of the genus Aphthovirus belonging to the Picornaviridae family. Seven immunologically different serotypes of the FMD virus are known, namely, A, O, C, Asia-1, South-African Territories (SAT) -1, -2 and -3, which comprise more than 65 subtypes. Initially 2 types were named: type O for Oise in France and type A for Allemagne (Germany) [10] . Later type C was recognized as an additional type in Germany [11] . Some 30 years later, work at Pirbright laboratory in England demonstrated 3 novel serotypes of FMDV in sample collected from the FMD outbreak in South Africa and called SAT1, SAT2, and SAT3. The seventh serotype, that is, Asia 1 was first recognized in a sample from Pakistan [12] .