Objective: Primary cutaneous follicle centre lymphoma (PCFCL) is an indolent, primary cutaneous B-lymphoma with an excellent prognosis but a high incidence of reccurence. Apart from standard surgery and local radiotherapy, targeted strategies with anti-CD20 (rituximab) has introduced new treatment modalities. Method: Woman, aged 82, with solitary skin lesion on her face. After surgical excision, histo-and immunohistochemistry with the ABC system on paraffin embedded tissue was performed. Results: Microscopically, a non-epidermotropic perivascular and periadnexal neoplastic infiltrate with a follicular growth pattern was observed. The lesion consisted of predominantly medium-sized centrocytes and several centroblasts enmeshed in a network of CD23(+) dendritic cells. Immunohistochemically, the neoplastic lymphoid cells were CD20, CD79a, BCL2 and BCL6 positive. CD30, MUM1 and Ig were all negative. The patient received one cycle of rituximab and 6 months later is free of disease. Conclusion: Primary cutaneous B-cell lymphomas (CBCL) account for 25 % of cutaneous lymphomas. PCFCL is one of the three major categories of CBCL, recently classified by WHO, (the other two: PCMZL and PCDLBCL, leg-type). BCL-2, except for systemic follicular lymphoma, it can also occur in PCFCL, as in our case. PCFCL, usually locally treated with surgery and radiotherapy, could possibly offer a candidate for anti-CD20 targeted therapy, especially in multifocal lesions. Objective: Thirteen and ten years old male patients admitted with 4 months interval, having diffuse hemorrhagic papules on extremities and trunk. The first has not responded to methorexate previously. The second had varicella infection 3 months before and, his rushes spreaded out recently. Method: Multiple punch biopsies of the first patient revealed epidermal necrosis, basal vacuolisation and subepidermal diffuse infiltrate composed of CD3 and mostly CD8 positive T cells showing a striking angiocentric distribution. There were CD30 positive large cells with vesicular nuclei both in epidermis and dermis. Some of the vessels exhibited lymphocytic vasculitis with fibrinoid necrosis. Punch biopsy of the second patient revealed subcorneal pustule, dyskeratosis and basal vacuolisation, papillary dermal edema, erythrocyte extravasation and severe lymphocyte-rich cellular reaction infiltrating the interface. Lymphocytes were CD3 and mostly CD8 positive. In between, there were large cells with vesicular nuclei exhibiting CD30 positivity. Results: Diagnoses were PLEVA based on the vascular and interface changes in accordance with clinical findings. Both patients responded to oral antibiotics. Conclusion: PLEVA is among the reactive conditions that can simulate CD30 positive lymphoproliferative diseases. Although CD8 positive lymphomatoid papulosis is defined in pediatric patients, no response was seen to oral antibiotics.