These studies were performed using a high-sensitivity 11.4-tesla FTICR mass spectrometer coupled with the AMT tag approach and our Huh-7.5 cell protein database. Using this method, we identified over 1,500 proteins from only 2 μg of a protein digest obtained from a liver biopsy sample [22] . The proteins identified included many of relevance to HCV infection and liver disease, including cellular proteins involved in lipid metabolism and the interferon response. The number of proteins identified by this approach is considerably larger than what has been reported in other published studies of the liver proteome, where less-sensitive methods, requiring milligram amounts of protein lysate, have identified only a few hundred proteins. Deborah Diamond leads the proteomics research in our laboratory and has recently authored a review that more fully discusses current developments in the application of proteomics to liver disease research [23] .