Mezger et al. also demonstrated that Dectin-1 is involved in the induction of several pro-inflamatory cytokines, chemokines and immune receptors [18] while Werner et al. showed that Dectin-1 is also regulating Th17-mediated immune response in the lungs [61] . Furthermore, Dennehy and Brown suggested a role of Dectin-1 mediating its own signaling, as well as synergizing with TLRs to trigger NFkB-mediated immune response against fungal pathogens [62] .