Quantitative HBeAg Assay as a Predictive Factor of HBeAg Seroconversion Induced by PEG-IFN -2a Therapy to HBeAg-positive Chronic Hepatitis B Y.Y. Zhu 1 , J. Dong 1 , Y.T. Chen 1 , J. Chen 1 , J.J. Jiang 1 1 Liver Diseases Research Center, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China RP, 350005 Background: To find predictive factor for HBeAg seroconversion in the treatment of HBeAg-positive chronic hepatitis B (CHB) by PEG-IFN -2a. Methods: HBeAg-positive CHB patients were given PEG-IFN -2a treatment for 48 weeks. Clinical data were collected every 3 months. Receiver Operator Characteristic (ROC) curve was employed to calculate positive predictive value (PPV), negative predictive value (NPV), sensitivity and specificity.