Neurobrucellosis with direct invasion of the CNS complicates less than 5% of infected individuals [58] . It may manifest as meningitis or meningoencephalitis, demyelination, cranial neuropathies, myeloradiculitis, cerebral arteritis, or spinal peripheral entrapment neuropathy [59] . Diagnosis can be made by blood culture, bone marrow aspiration, or serology. In patients with neurological symptoms, CSF analysis reveals a lymphocytic pleocytosis and elevated protein. CSF cultures are positive in 13% of cases [60] .