A solid rationale explains the utilization of vasopressors in daily practice [54] , but the few comparative studies and the combination of different molecules account for their practical selection. Combining norepinephrine (noradrenaline) and dobutamine improved hemodynamic parameters of hepatosplanchnic circulation [55] but required invasive monitoring procedures, without clinical benefit. Dopamine and epinephrine are vasoconstrictors that also increase cardiac output, but their metabolic effects may be harmful [56, 57] . In addition, use of vasopressors has been associated with poorer outcomes in septic patients, but their influence on mortality was unclear [58] .