• Do ducks (wild or domestic) serve as the reservoirs of the Asian H5N1 HPAI viruses? • What genomic characteristics of ducks are associated with natural resistance in some species? • Is antigenic diversity driven naturally in ducks or is it the consequence of vaccine usage? • What dose of vaccine antigen is required to prevent transmissible levels of excretion of H5N1 HPAI viruses by ducks of different species (and geese and swans)? • Is eradication of Asian H5N1 HPAI viruses achievable?