The rate of discovery of new RNA families is accelerating rapidly, facilitated by advancements in new sequencing technologies (12, 13) and targeted computational screens (14) (15) (16) (17) . Keeping abreast of these updates whilst still ensuring the quality of alignments and secondary structures is an ongoing challenge for Rfam. We continue to evaluate new technologies and techniques as they emerge and will adopt new procedures for building and checking Rfam families as necessary.