Conclusion: The frequency of K-ras mutation and HER2 amplification are in agreement with other studies on this topic. In our study, the two seem mutually exclusive events. Objective: Gastric carcinoma is related with cancer genetic susceptibility that can be investigated as single nucleotide polymorphisms (SNPs) and as cytokine genes are known to predispose to malignant disease, several polymorphisms of Interleukin-6 (IL-6) gene have been reported to in some may be associated with tumour progression including inhibition of malignant epithelial cells apoptosis and stimulation of angiogenesis.