Corelation between histopathologic diagnosis with p16 and Ki67 immunostaining, cytologic features in cervical neoplasia C. Altunkaya * , S. Yilmaz, A. Barin, S. Ekici, G. S. Yalcin, M. Caydere, H. Ustun * S.B Ankara E. A.H, Pathology, Turkey Objective: Frequency of cervical carcinoma decreases nowadays since cytologic screening methods have been using extensively. The incidance of cervical intraepithelial neoplasia increases. Cytologic diagnosis og these lesions are substantially important. So we aim to identify the role of p16 and Ki67 immunostainings for predictive factors of cervical neoplasia. Method: The study was conducted January 2007 to January 2012. Ninety-three cases (mean age 43,9; range 22-71 years) diagnosed as squamous intraepithelial lesions were included, Objective: There are several prognostic factors in melanoma. It was suggested that HER-3 expression may influence the tumor behavior. The aim of the study was to investigate the relationship of HER-3 expression with various prognostic factors. Method: HER-3 expression was evaluated in 52 melanomas, 26 without metastases and 19 with lymph node and 7 with distant metastases. Membranous, cytoplasmic and nuclear HER-3 expression was separately analysed. The staining intensity and percentage of positive tumor cells were evaluated. Results: The cytoplasmic staininig was seen in all cases, with average intensity of 2 and percentage of positive cells ranging from 5 % to 90 % (mean 48.8 %). The percentage of cytoplasmic HER-3 positive cells was inversely correlated with Clark and Breslow stage (R=−0.29 and R=−0.43). Cytoplasmic HER-3 reaction was significantly stronger in cases with lymph node metastases (2.3 vs. 1.8 p<0.03). In 22 cases a dot-like cytoplasmic reaction was seen. Membranous positivity was seen in 28 cases (54 %). Conclusion: HER-3 may play a role in melanoma progression. It may be involved in lymphatic dissemination. Further studies of prognostic significance of HER-expression in melanoma are needed.