Children with HBoV co-infections seemed to have more AOM (47%) than those with single HBoV infections (33%), but this difference could be explained by inclusion of 7 RSV-positive children in this group. The highest rate of AOM (72%) was in children with RSV-induced wheezing. Alper et al. reported differences in frequencies of various respiratory viruses associated with AOM (HBoV was not included), but statistical significance was not achieved (40) . We found a difference in the frequency of AOM between children with RSV-induced wheezing and those with HBoV-induced wheezing.