With respect to the relation between occupation and educational level and QoL scores, the PCS was strongly associated with occupation and level of education (P < 0.001). The overall MCS was not related to occupation or the level of education (P 5 0.206 and P 5 0.177, respectively) (see Supporting Information Tables V and VI) . Occupation and the level of education were not different between different genotypes and were not related to pain rates.