Results: In the results, acute hypoxia caused a significant (p<0.05) decrease in major antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and glutathione (GSH) content in lean groups when compare to their controls. The decrease in the activities of all antioxidant enzymes was also noticed in obese group with hypoxia treatment. However, this decrease was not significant in case of CAT, GSH-Px activities and GSH content. The MDA levels (lipid peroxidation marker) were higher in obese rats compare to lean rats.