As shown in Fig. 10 , primed neutrophils from transgenic animals were able to bind E.coli-Opa 52 much greater than E. coli-vector control. Controls included binding of the parental (Opa-) strain on wild type neutrophils and Opa52-expressing bacteria binding to human neutrophils. These results suggest that the neutrophils in the transgenic animals may mimic the behavior of human neutrophils towards binding of Neisseria pathogens.