We were able to identify models for cytokine circulation during dengue acute phase that may vary with clinical manifestations. MIP-1β was for the first time associated with a good prognostic and was identified in the different disease models presented here. MIP-1β has been earlier detected after Dengue virus cell stimuli in vitro [34, 35] but preliminary studies in vivo did not report their role in severity. In accordance with a protective role for MIP-1β, changes in MIP-1β levels were significantly correlated with decreases in viral titre after Hepatitis C treatment [17] . In addition, MIP-1β was up regulated in acute infection in chimpanzees only when viral clearance took place, but not in those animals which failed to eradicate the virus [36] .