In 2010, China became the country with the largest diabetic population in the world. The Northern and Southern Chinese populations are distinct in genetic marker analyses [9] , meaning disease markers identified in northen populations may not be shared by the Southern populations. The primary aim of the current study is to establish the association between APOM and T2D susceptibility in a Southern Chinese cohort in Hong Kong. By assuming the same effect size (OR = 1.934) and disease allele frequency as observed in the studies of Northern Chinese [8] , the power of the current case-control study is over 95% with 1234 cases and 606 controls. The secondary aims are to examine for association between APOM and component metabolic traits as well as to further assess the function of the gene.