Background/aims: As human immunodeficiency virus (HIV) infected children who are receiving antiretroviral therapy (ART) are living longer in China, comorbidities of hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection should be carefully considered when making management decisions. However, the coinfection rate of either HBV or HCV is unknown in HIV-infected children in China. We evaluated the seroprevalence of HBV and HCV in the China national pediatric ART cohort of HIV-infected patients.