''Receptor binding'' GO0005102 also includes the Notch ligand and known c-secretase substrate Jagged 2 [27, 28] , as well as the asecretase ADAM 10 [29] , four members of the Wnt family (Wnt6, 7a, 9b and 10a) and, the aforementioned b-catenin. Indeed, the translocation of b-catenin is mediated by ADAM 10, which is of the same functional cluster [30] .