Several groups have compared clinical features of HBoV infections with those of other respiratory virus infections. In those studies, diagnoses of infection with HBoV were based only on PCR positivity of NPAs, which as we showed, is not an ideal marker for detection of acute HBoV infection. We assessed clinical findings of our patients with serologically verified acute HBoV infections. Comparison of HBoV-induced wheezing with that induced by rhinovirus is notable because rhinovirus is commonly associated with wheezing in older children and has been recognized as a risk factor for recurrent wheezing and asthma in young children (34) (35) (36) . Also notable is a comparison of HBoV and RSV because RSV is the dominant cause of bronchiolitis in infants (37, 38) . Our data showed that wheezing induced by RSV occurred at the youngest age (median 10 months), followed by that induced by HBoV (17 months), and rhinovirus (25 months). Age-adjusted comparisons showed that HBoVinfected children were hospitalized longer than rhinovirusinfected children. Illnesses after HBoV infection lasted longer than illnesses after rhinovirus infection. However, we did not demonstrate that co-infection with HBoV would increase illness duration or severity, as has been reported for rhinovirus-and RSV-induced bronchiolitis (39) .