The third issue that will be collegially discussed is as to whether there are any liver metastases. The surgeon will illustrate that the presence of liver metastases will contraindicate surgical treatment, especially depicting small liver metastases may avoid unnecessary laparotomies that are always associated with a different level of morbidity and mortality. The pathologist will show us the criteria to diagnose a liver metastases and the importance of histological subtyping (i.e. adenocarcinoma vs. endocrine neoplasm).The radiologist will illustrate the sensitivity of different imaging modalities in detecting liver metastases and the improvement in sensitivity after the administration of liver-specific contrast agents. Furthermore, the diagnostic imaging criteria for the differential diagnosis of focal liver lesions will be illustrated. The fourth issue that will be collegially discussed is whether there are there positive lymph nodes. The surgeon will illustrate that the lymph nodes are a marginal surgical problem. The pathologist will illustrate the lymph nodes more frequently involved in pancreatic cancer and the criteria for a pathological diagnosis. The radiologist will illustrate the strength and especially the limitation in characterising lymph nodes. The fifth issue that will be collegially discussed is whether the tumor is locally advanced. The surgeon will illustrate the criteria that may contraindicate the surgical procedure, namely which are the vessel of interest in planning a surgical procedure that a radiologist should take care of. The pathologist will illustrate the criteria for vessel wall infiltration and the pattern of peri-vessel infiltration. The radiologist will illustrate which are the diagnostic imaging criteria to define vessel wall infiltration and their relative accuracies.