Although there is no record of Porcine Circovirus being able to infect man, precautions should be taken when porcine derived substances, such as trypsin, are used in animal cell technology. As this type of virus is very resistant it is preferable to avoid contaminations of the cell culture, and thus of the biotech product, than to try to separate the product from the virus (due to stability reasons autoclaving the final product is not possible).