Objective: The disturbance of apoptosis represents an important event in the genesis of tumors with different localization. The study of anti-apoptotic protein Bcl-2 expression from the perspectives of the prognostic and predictive value in prostate cancer has led to inconsistent results, even contradictory. Method: Expression of Bcl-2 was analyzed in 3 groups of prostatic carcinoma: localized, locally advanced and with distant metastases. For histological grading of carcinomas we used Gleason score. Classification of the tumors into prognostic subgroups was made according to NCCN Guidelines. For the immunohistochemical study we used anti-Bcl-2 antibody (clone 174), EnVision system, visualization with diaminobenzidine. The results of immunohistochemical reaction were assessed by evaluating the extent and intensity of immunostaining. Statistical analysis was performed using STATA 9.2. Results: 17 of the 59 analyzed cases of prostate carcinomas showed Bcl-2 over-expression: 5,9 % localized carcinomas, 23,5 % locally advanced carcinomas and 70,6 % carcinomas with distant metastases (p<0.001). Although most of the Bcl-2 positive tumors were poorly and moderately differentiated, the correlation between Bcl-2 over-expression and tumor grade did not show statistical significance (p=0,085). Conclusion: Bcl-2 overexpression in advanced prostate carcinomas suggests involvement of this marker in the progression of tumors in this location.