Results in Figure 6 show that pre-exposure to T. esculentum extracts can significantly reduce infectivity of RV. This finding broadly points to inhibition of RV cytopathic effect by T. esculentum extracts prior to or during virus entry (specific mechanisms were not determined). Exposure of RV (at 1 × 10 7 Table 3 shows correlation of antiviral effects of different treatments with T. esculentum extracts on different cell cultures. There was high positive correlation between CLAB and H4 cells (r = 0.94), moderately positive correlation between CLAB and CIEB cells (r = 0.57) in survival from rotavirus cytopathic effects after coincubation with T. esculentum extracts, while a weak negative correlation between H4 and CIEB cells (r = −0.02) was observed after coincubation. Highly positive correlation between survival of CLAB cells after coincubation compared to preincubation with T. esculentum extracts (r = 0.91) and moderately positive correlation between CIEB cells pre-and coincubated with the extracts (r = 0.59) were observed. Poorly positive correlation between H4 cells co-and pretreated with the extracts was observed. Moderate positive correlations were also observed between survival of and nitric oxide release from CLAB (r = 0.43) and H4 cells (r = 0.79), as well as highly positive correlation in levels of nitric oxide release from H4 and CLAB cells (r = 0.9). Negative correlation was observed between survival rates and TER of cells (H4, CLAB and CIEB) after coincubation of rotavirus with T. esculentum extracts.