IFN are among the first molecules synthesized in response to viral infections [9] . The IFN family includes three classes. Type I comprises the well known IFNa and IFNb. The only member of type II IFN is IFNc. Type III IFN comprises IFNl1, -l2, and -l3. All classes of IFN bind to different receptors and are structurally not related [10, 11] . Type I IFN belong to the key cytokines produced by influenza A virus-infected epithelial cells [12, 13] . The antiviral activity of type I IFN is mediated by a set of IFN-induced genes (ISGs).