Objective: The aim of this retrospective study is investigate the role of Hofbauer cells in early fetal losses. Method: The slides obtained from archieval blocks of missed abortion (MA, n=15) and blighted ovum (BO, n= 15) cases and unwanted pregnancies materials (control group, n=15) were stained by immunuhistochemical methods using CD68 and CD31 antibody to label Hofbauer cells and endotelial cells, respectively. Results: The mean number of vilous Hofbauer cells was found to be significantly higher in both BO and MA in contrast to the control group (p=0.005 and p<<0.001, respectively). However it was not significantly different between BO and MA (P=0.04). Chalkey method revealed no statisticaly significant difference in the control group in comparison with MA and BO in (P=0.29, P=0.09, respectively). Higher microvessel scorring were found in MA in contrast to BO and the control group (p=0.003 and p= 0.003, respectively). However, there was no difference between the control group and BO (p=0.54). Conclusion: We think that Hofbauer cells may be of biological importance in early fetal losses and play a role on defective vasculature formation in MA.