Bansal et al. [13] recently carried out a comparative analysis of two classes of suggested vaccination strategies, namely, the mortality-based strategies that target the high-risk populations and the morbidity-based strategies that target the high-prevalence populations, by applying the methods of contact network epidemiology to a model of disease transmission in a large urban population. Using a range of mortality rates reported previously for past influenza epidemics and pandemics, they concluded that the optimal strategy depends critically on the viral transmission level (or reproduction number) of the virus. That is, the morbidity-based strategies outperform the mortality-based strategies for moderately transmissible strains, while the reverse is true for highly transmissible strains. However, they also cautioned that when information pertaining to viral transmission rate of a particular disease and the frequency of new introductions into the community prior to an outbreak is unreliable or not available, a mortality-based vaccination priority is recommended. This further demonstrates the importance of targeting and, moreover, the uncertainty surrounding this issue.