The basic functioning principle behind all microarray technology is the binding, and subsequent measurement, of target biological specimens of interest to complementary probes arrayed in a spatially addressable fashion. Typically, a planar surface, such as a glass slide, is used to support an array of spots containing the probes. As a consequence of using spatially addressable probes, a large number of different targets can be measured in a single experiment. For example, in the case of DNA microarray technology, which provides the basic enabling technology for functional genomics, the targets are fluorescent mRNA molecules (indicators of genomic expression) that are hybridized to gene-specific DNA probes immobilized on a planar surface. In a similar fashion, the enabling technology for functional immunomics is the immunomic microarray. The basic technologies for immunomic microarrays that we consider in detail in this paper are antibody, peptide, and peptide-MHC microarrays (see Table 1 for a summary of these technologies). Other functional immunomic approaches include dissociable antibody microarrays [48] , cell microarrays [49, 50] , serum microarrays [51] , peptide libraries [52, 53] , and serological analysis of cDNA expression libraries (SEREX) [54] [55] [56] [57] [58] . There are significant technological challenges inherent in fabricating immunomic microarrays, including the identification of a workable surface coating for the glass, appropriate probe concentration and target incubation times, and suitable spot size and interdistance [59] [60] [61] [62] [63] [64] .