Foot-and-mouth disease virus (FMDV) is an important veterinary pathogen which can cause widespread epidemics. Many works have been carried out to develop and validate diagnostic tests in regard to the FMD. Conventional techniques to detect FMDV infection are either not precisely specific or lack an optimum degree of sensitivity which cannot be overlooked when screening of a herd is concerned. With the critical need for improved diagnostic tests to detect viral infection, effort need to be concentrated on the development of simple, rapid, noninvasive tests that can be performed without expensive laboratory equipment. In this context although various molecular tools are very promising but to make it a successful tool search for more rapid and accurate tests as well as an earlier detection system in preclinical state are needed for the hour. Renewed Global Partnerships and Redesigned Roadmaps for Rabies Prevention and Control Canine rabies, responsible for most human rabies deaths, is a serious global public health concern. This zoonosis is entirely preventable, but by focusing solely upon rabies prevention in humans, this “incurable wound” persists at high costs. Although preventing human deaths through canine rabies elimination is feasible, dog rabies control is often neglected, because dogs are not considered typical economic commodities by the animal health sector. Here, we demonstrate that the responsibility of managing rabies falls upon multiple sectors, that a truly integrated approach is the key to rabies elimination, and that considerable progress has been made to this effect. Achievements include the construction of global rabies networks and organizational partnerships; development of road maps, operational toolkits, and a blueprint for rabies prevention and control; and opportunities for scaling up and replication of successful programs. Progress must continue towards overcoming the remaining challenges preventing the ultimate goal of rabies elimination. Today, RNA viruses play an increasingly important role in emerging human diseases throughout the world [1] [2] [3] [4] [5] . One of the main reasons for this is their ability to evolve rapidly, adapting to new species of hosts and thus to expand their range [6, 7] , including humans (i.e., new zoonotic diseases). Social and environmental changes also contribute to providing new ecological niches and promoting the rapid selection of novel virus variants [8] [9] [10] . This group of viruses includes the causative agents of rabies. As with most generalist agents of a zoonotic nature, rabies is a 2 Veterinary Medicine International very complex disease, in part because of its wide global distribution, the diverse number of virus variants and host species, its extremely high case fatality rate, and for its existence at the border between animal and human health.