Four unknown tumor related genes (DEPDC1B, ASPM, FCN2 and BBOX1) were detected in this study. Conclusion: The combination with laser capture microdissection and microarray was effective in screening the differentially expressed genes of HCC. Background/Objective: Young patients present with large HCC on initial presentation are not uncommon. Our aim is to study the computed tomography(CT) imaging of HCC and the clinical features of this special group of patients. Methods: 521 HCC patients had CT imaging of liver peformed in a three year period, 385 patients had CT imaging peformed at the time of initial HCC diagnosis in our centre and were selected. They were divided into three age groups: Young patients with age </= 40 year-old(Group 1), Age 41 to 60(Group 2), Age >60(Group 3) to study imaging and clinical factors. Univariate and multivariate analysis by Cox regression model done to look for prognostic predictive factors. Results: