Results: Among the total of 37 cases, no HPV DNA was detected in 33 cases (89.2 %). 4 cases were tested HPV positive (10.8 %) , of which 1 was HPV 16+, 1 was HPV 18+ and 2 were non-high-risk HPV type. The non-high-risk HPVs were detected in patients with previously treated SCC of the mouth (n=1) and the oropharynx (n=1). Patients with high-risk HPVpositive tumors had no history of oropharyngeal cancer. Conclusion: Our study revealed the presence of oncogenic HPV genotypes in a subset of esophageal cancer. The low rates of viral infection detected suggest that HPV unlikely represents a significant etiologic factor in esophageal carcinogenesis. Further studies are needed to confirm these data in larger populations. Objective: Gastric cancer is the second leading cause of cancer mortality in the world. Amplification of HER-2/neu oncogene has become an important biomarker for identifying patients who will respond to HER-2 targeting therapy. The rate of HER2 positivity in gastric cancer is variable, ranging from 6 % to 35 %. Objective: Gastrointestinal stromal tumors (GISTs) are primary mesenchymal tumors that arise in the GI tract. Only 3-5 % of GISTs occur in the duodenum. Here, we report a rare case of duodenal GIST with extramural growth that mimicked a pancreatic tumor. Method: A 57 years old male patient was admitted to our hospital for duodenal ulcer and gastrointestinal bleeding which was diagnosed in an another clinic by endoscopy.