Background/Aims: Incidence of Fulminant Hepatic failure (FHF) in Hepatitis E is high in pregnancy particularly during 3 rd trimester when there is an altered status of hormone and immunity. Progesterone receptor (PR) up regulation provides fetal protection via immunosuppression but lower immune status in pregnancy may add to the disease severity. Till now, no data is available whether PR can play any role in Hepatitis E disease severity during pregnancy. PROGINS, a haplotype of PR consisting of 320-bp insertion in intron G together with point mutations in exons 4 and 5 is associated with increased stability and higher transcriptional activity. The aim of the study is to analyze PR mutation (PROGINS) and m RNA expression in hepatitis E virus infected pregnant women with AVH and FHF. Methods: A total of 68 AVH and 32 FHF cases were studied. Blood and placental tissue were collected from the Medicine and Gynecology wards of LNJP hospital, New Delhi. Cases were screened for acute viral markers by commercially available ELISA kit. Extraction of DNA from blood and RNA from placental tissue was done by Qiagen kit. Mutation in PR was detected by PCR-RFLP. Semiquantitative rt-pcr for PR expression was performed in placental tissue using beta-actin as internal control. Results: PR mutation (PROGINS) was significantly more in FHF compared to AVH (28.1% vs 10.3%, P value<0.05). Protein expression was found higher in PROGINS carriers. Conclusion: Progesterone receptor mutation (PROGINS) may have a role in the Hepatitis E disease severity in pregnant women. Results: The hepatitis E was predominantly sporadic, some patients superinfected with other viral hepatitis, especially hepatitis B. In the old patients, jaundice lasted longer and the length of stay was longer, the incidence of complication was higher than the young men. The incidence of complication in the superinfected group was higher than the simple infection. The transaminase in the simple infection group was obviously raise than superinfected with liver cirrohsis.