After the first description of HBoV, it has been reported from various countries, pointing to a worldwide endemicity. HBoV has been identified in Europe [34, 35, 36, 37, 38, 39, 40] , Asia [41,42,24,43], Australia [18, 44, 23] , Africa [25] and America [45, 19, 46, 20] . Until now, it is known that HBoV exists as a single lineage with two different genotypes [47] . The prevalence of HBoV ranges between 1.5 to 19.3 % [19, 48] . Primary infection with HBoV seems to occur early in life and children between the ages of six and 24 months seem to be mostly affected [31, 49, 43, 22, 50] , but older children can be infected, too. Newborns may be protected by antibodies against HBoV derived from the mothers A seasonal distribution of the virus has not yet been clearly demonstrated. HBoV has been detected throughout the whole year, with peak seasons varying from year to year and from study to study. However, HBoV has been detected mostly in fall and winter months [39, 55, 56, 57] .