The unfolded protein response (UPR) of the endoplasmic reticulum (ER) is a fundamental stress response used by eukaryotic cells to match protein synthesis demand to its capability to fold proteins within the ER to maintain cellular homeostasis [9] . In C. elegans and other animals there are three transducers that signal from the ER to activate this response. These three distinct arms of the UPR are mediated by IREI, ATF6, and PERK in mammals [10] , which correspond to the genes ire-1, atf-6, and pek-1 in C. elegans [11, 12, 13] . All three pathways are regulated by the ER chaperone BiP in response to an increase in unfolded proteins [9] .