Since the discovery of SAFV, several articles have provided insight into its epidemiologic and, to a minor degree, clinical signifi cance. Saffold viruses are distributed worldwide (6, (13) (14) (15) (16) (17) (18) (19) , and 2 serologic studies have demonstrated that infection occurs early in life (14, 20) . However, fi nding an association with human disease has thus far been elusive. Most studies (13, 15, 17, (20) (21) (22) have tried to associate SAFV with gastroenteritis, but no convincing results have been produced. A few studies (16, 18, 21, 23) analyzed the clinical signifi cance of SAFV virus in the respiratory system, but no substantial association between the virus and respiratory symptoms or disease has been made. Only 1 study (21) reports having tested invasively collected sample material (CSF samples), but no fi ndings were positive.