Having identified 33 antigens that are correlative with convalescent candidemia in comparison to the negative control groups, we next wanted to determine the temporal change in IgG response to these 33 antigens during the transition from acute infection (AI), to early convalescent (EC), and mid convalescent (MC). A two-way hierarchical cluster analyses was performed on differential IgG responses to the 33 antigens in 3 patients with AI, EC and MC sera, and 4 patients with only AI and EC sera ( Figure  S3) . A one tailed t-test was carried out to look for differences where the EC antigen intensity is significantly greater than the AI antigen intensity, possibly indicating the selection of a protective antibody response. We observed a significant increase in the IgG response from AI to EC in the following antigens, which are ranked according to their p-values: Apc5 (2) 