Majority had NASH. 47.8% were obese and 41.3% had dyslipidaemia. 28.3% had hypertension, 28.3% insulin resistance and 13% were diabetics. 6.5% had hypothyroidism. None had hepatitis C. ALT was raised in 72% and AST in 40%. Although all patients with NASH did not have elevated ALT, it was raised in majority, contrary to AST, which was normal in most. Conclusion: Majority NASH patients in Bangladesh are obese. Other leading causes of NASH include dyslipidaemia, hypertension and insulin resistance. Some NASH also had diabetes and hypothyroidism. This study also reveals that elevated ALT in patients with NAFLD is suggestive of fibrosis, although normal serum ALT does not exclude NASH. The study further suggests that ALT is superior to AST in predicting NASH. Background: Non-alcoholic fatty liver disease is prevalent in obese patients. Liver biopsy remains the best diagnostic tool for confirmation. We tried to find out the correlations of laparoscopic parameters with histology and laboratory data. Besides, we also evaluated the effectiveness of laparoscopy in liver disease diagnosis. Methods: In the period of one year and five months,126 morbidly obese patients submitted to laparoscopic bariatric surgeries at our institutions were prospectively studied. Results: Laparoscopic parameters of significant correlations with histologic steatosis, inflammation and fibrosis were summarized in Table 1 . Besides, important parameters with relationships to laboratory data were summarized in Table 2 Department of Internal Medicine, Seoul National University Hospital Gangnam Healthcare Center, Seoul, South Korea, 2 Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, South Korea Background/aims: Hepatic fibrosis is associated with poor prognosis in non-alcoholic fatty liver disease (NAFLD). Recently, many non-invasive fibrosis markers have been studied to overcome the limitations of liver biopsy. Among them, BARD score and Guha's simple panel are easy to use in clinical practice. In this study, we evaluated the efficacy of BARD score and Guha's simple panel as a noninvasive fibrosis marker in Korean NAFLD patients. Methods: Data from 79 patients with biopsy-proven NAFLD in Seoul National University Hospital from 2000 to 2007 were used. BARD score and Guha's simple panel were calculated by using clinical and biochemical data and were compared with the histological fibrosis stages. Results: Stage 0 fibrosis were found in 67 patients, stage 1 in 4, stage 2 in 2, stage 3 in 1 and stage 4 in 5. The relationship between fibrosis stage and BARD score ( = 0.43, p < 0.001) was statistically significant. All patients with advanced fibrosis (stage 3-4) had BARD score greater than 2. Mean values from original Guha's simple panel for no fibrosis were not different between the patients with and without fibrosis. However, after adjusting coefficients by logistic regression analysis, the differences in mean values became statistical significant (p < 0.001). Conclusions: Our data suggest that Bard score may be effective for detecting high risk patients for advanced fibrosis, and modification of coefficients within the Guha's simple panel may be needed to use as a fibrosis marker in Asian NAFLD patients.