Conclusion: It seems to be that ER is more prevalent in females but for showing of its role in prognosis, further studies are recommended. Objective: Type 2 diabetes mellitus (T2DM) treatment aims to control metabolic effects, preserve pancreatic function and reduce complications, such as nephropathy. This study intends to evaluate the effects of sitagliptin, a dipeptidyl-peptidase-4 inhibitor, in pancreatic and renal lesions in Zucker Diabetic Fatty (ZDF (fa/fa)) rats, an animal model of T2DM. Method: Male obese diabetic ZDF (fa/fa) rats, 20-weeksold, were treated with vehicle or sitagliptin (10 mg/kgBW/ day) for 6 weeks, and compared with lean control ZDF rats (n=8 each). Biochemical parameters as well as pancreatic and renal lipid peroxidation and histopathology profile were assessed. Specimens we stained with haematoxylin-eosin and periodic acid of Schiff, and examined by light microscopy. Lesions were evaluated by a semiquantitative rating. Endocrine/exocrine pancreas and renal glomerular, tubulointerstitial and vascular lesions were assessed and scored (0 3/0-2). Results are mean ± SEM; ANOVA and Duncan's post-hoc analysis (P≤0.05 was considered as significant). Results: Sitagliptin improved metabolic parameters, reduced lipid peroxidation (p<0.001) in both organs and significantly prevented major diabetic pancreatic and renal lesions in obese diabetic ZDF rats. Conclusion: Sitagliptin seems to comply with the three main objectives of T2DM therapeutic management. Underlying molecular mechanisms deserve further elucidation, but could be related with metabolic improvement and reduction of oxidative stress. Objective: Thyroid tumors of uncertain malignant potential (TT-UMP) include follicular and well-differentiated tumors of UMP (FT-UMP/WDT-UMP), as it refers to the presence of questionable capsular/vascular invasion or incompletely developed papillary thyroid carcinoma (PTC)-type nuclear changes. However, a diagnosis of TT-UMP is difficult in most cases. We aimed to investigate whether immunohistochemistry (HBME-1, Cytokeratin-19, Galectin-3, CD56 and p63) provides additional information concerning such lesions. Method: We performed an immunohistochemical analysis on 14 WDTs-UMP and 4 FTs-UMP.