Objective: Determination of molecular features in breast carcinomas, such as hormone receptor expression, can guide clinicians to the optimal choice of therapy. In this study, the relationship between the histologic grade, pathologic stage and the prognosis of invasive lobular carcinoma of the breast, and the tissue expression levels of ER, PR, HER-2/neu, p53, bcl-2, Ki-67 and E-cadherin was investigated. Method: 31 cases of invasive lobular carcinoma of the breast, from 2003 to 2011, were included in this study. A single best representative paraffin block was selected for each case and H&E staining and immunohistochemistry procedures were performed. Ki-kare test was used for statistical method. Results: 24 of 31 cases had classical lobular carcinoma, 7 cases had tubulolobular, pleomorphic, signet ring cell, or apocrine features. The median age of patients was 54 years. ER and PR were positive in 28 cases. All cases were negative for E-cadherin. Ki-67 was greater than %15 in 2 cases with pleomorphic lobular carcinoma. p53 positivity increased with grade. In 14 cases p53 was negative and bcl-2 was positive. Bcl-2 and p53 were positive in 29 and 17 cases respectively.