For most viruses that replicate in the cytoplasm of infected cells, lipids are essential for the replication of viral genomes. Both enveloped and non-enveloped viruses induce extensive ultrastructural changes in infected cells. Host-derived membranes are rearranged to provide extensive platforms that help to assemble arrays of replication factories [2] [3] [4] [5] [6] . Some of these factories are housed in specialized membrane compartments that assist in evading host antiviral defense mechanisms [2] [3] [4] 7] . These compartments also function to increase the local concentration of molecules necessary for efficient viral RNA replication and particle assembly. Recent advances in electron tomography techniques have been instrumental in providing a three-dimensional perspective of these virus-induced membranes [2] [3] [4] 7] . However, the metabolic cost to the host or vector and the contribution of lipid biosynthesis and trafficking to the formation of these replication factories is yet in its early stages of investigation [8] [9] [10] [11] [12] .