Objective: The histopathologic diagnosis of early mycosis fungoides (MF) is often difficult. The lesions can mimic a variety of inflamatory dermatitis. We aimed to establish and draw attention to the most frequent histopathologic and immunohistochemical features of MF. Method: We reviewed 115 skin biopsies of clinicopathologically diagnosed MF cases at Medical University of Ankara. We looked for a) epidermotropism, atypical lymphocytes, morphologic features in the epidermis, dermoepidermal junction and dermis b) immunohistochemical staining ratios of CD3, CD4, CD8, CD20, CD30 and expression loss of CD5, CD7. Results: Atypical lymphocytes) (96 %), dermal fibrosis (90 %), epidermotropism (86 % single cells, 44 % linear arrangement, 15 % Pautrier's microabscesses, 83 % 'haloed' lymphocytes), epidermal acantosis (72 %), basal vacuolar degeneration (focally 43 %, marked 15 %) and a perivascular lymphocytic infiltrate were the most common and important features. Dermal edema (46 %) extravasated erythrocytes (34 %), spongiosis (27 %), eosinophils (17 %) and necrotic keratinocytes (14 %) were the less seen and non-specific ones. Immunohistochemical results correlated with a ratio of 78 % CD4, 22 % CD8 positive MF. Expression loss of CD7 was seen in 73 %, CD5 in 31 % of cases. Conclusion: Diagnosis of early MF requires the correlation of morphologic, immunohistochemical and clinical features. Also due to the disease's heterogenity, biopsies from different locations and rebiopsies will enhance the diagnosis.