In addition to the information that the ED-SSS can provide for disease control, it can open avenues for further investigation. For example, in addition to the neurological syndrome, asthma syndrome, and syndrome for severe symptoms, there were clear and consistent weekend and holiday increases in the visits of other nine syndrome groups. Because cost of ED visits in Taiwan is not as expensive as it is in other countries, especially the United States, it is very likely that many patients seek ED medical care when local clinics are closed on weekends and holidays. It is also possible that the gathering of people on the holidays would increase the transmission of certain pathogens, particularly on cold days in closed spaces where respiratory viruses including influenza virus are easily transmitted. Therefore, future research might want to investigate the effect of holidays on the aberration detection of outbreaks and prediction of number of cases for certain infectious diseases using Taiwan's ED-SSS.