Our previous studies have shown peptide epitope and proteinbased antigens can be made far more immunogenic when covalently attached to Pam 2 Cys in order to target their delivery via TLR2 to dendritic cells (DCs) [44] . This results in the induction of robust antibody and CD8 + T cell-mediated immune responses and has been shown for multiple indications [44] [45] [46] [47] .