Objective: Prostatic adenocarcinoma is the most common cancer and second leading cause of cancer death in men. The incidence of prostate cancer has been increasing because of efficiency of modern cancer scanning programs and residual awareness of the patients. For that reason, there is a considerable increase in the number of prostatectomy specimens in the university and research hospitals.It is costly and time-consuming procedure and causes in turn increased workload. The aim of this study is to compare the results of total and alternative sampling methods and to delineate the differences if there are any. Method: Totally embedded 50 radical prostatectomy specimens were randomly selected and evaluated for key pathologic parameters. These cases then were reevaluated with limited sampling. The limited sampling method was built to include similarly embedded apical margins, bladder neck margins and seminal vesicles. In addition to that new slices were selected by skipping every other slice as differently from totally sampling protocol.