Our study suggests that morphologic features combined with immunohistochemical panel of HMWCK, CK19, HBME-1, Galectin-3 and fibronectin can help to distinguish benign and malign thyroid neoplasms and TPCFV from follicular adenomas. RET/PTC expression has been nonspecific but its detection can be a useful tool combined with immunohistochemistry for diagnosing TPCFV.