Analysis of the whole cell lipidome indicated that unsaturated PC was the most up regulated phospholipid in DENV infected cells. Membranes that are similar or derived from the ER are enriched in unsaturated lipids, primarily PC [39] . Although DENV-induced membranes in mammalian systems are ER-derived, it is unknown if the same is true in mosquito cells. While PC is known to form planar membranes, unsaturated PC induces membrane curvature which may be important for maintaining the highly curved membranes observed in DENV-infected cells [40] . PC enriched membranes are also more fluidic compared to the rigid membranes enriched in SM and cholesterol, which may be a feature attractive to DENV infection [41] .