Table S1 List of contigs (e-value,10-3) of Ruditapes philippinarum including sequence, length, description (Hit description), accession number of description (Hit ACC), e-value obtained and database used for annotation (Blast).  Distribution and Risk Factors of 2009 Pandemic Influenza A (H1N1) in Mainland China Data from all reported cases of 2009 pandemic influenza A (H1N1) were obtained from the China Information System for Disease Control and Prevention. The spatiotemporal distribution patterns of cases were characterized through spatial analysis. The impact of travel-related risk factors on invasion of the disease was analyzed using survival analysis, and climatic factors related to local transmission were identified using multilevel Poisson regression, both at the county level. The results showed that the epidemic spanned a large geographic area, with the most affected areas being in western China. Significant differences in incidence were found among age groups, with incidences peaking in school-age children. Overall, the epidemic spread from southeast to northwest. Proximity to airports and being intersected by national highways or freeways but not railways were variables associated with the presence of the disease in a county. Lower temperature and lower relative humidity were the climatic factors facilitating local transmission after correction for the effects of school summer vacation and public holidays, as well as population density and the density of medical facilities. These findings indicate that interventions focused on domestic travel, population density, and climatic factors could play a role in mitigating the public health impact of future influenza pandemics. In early April 2009, human cases of infection with 2009 pandemic influenza A (H1N1) virus were first identified in the United States and Mexico (1) . The virus then spread rapidly to other regions of the world. As of January 24, 2010, laboratory-confirmed cases of pandemic influenza (H1N1-2009) were being reported in more than 209 countries or regions worldwide, with 14,711 deaths among confirmed cases (2) . Pandemic influenza was introduced to mainland China on May 9, 2009 (3, 4) , and then spread across the whole country. By the end of 2009, more than 120,000 confirmed cases were reported to the Chinese Center for Disease Control and Prevention (CCDC), including 648 deaths (5) . Information on reported cases was released daily by the Ministry of Health of the People's Republic of China in the early stages of the pandemic and then twice weekly later on.