Poster Exhibition -Liver Fibrosis Poster Session, Hall 5B Background/Aims: HMG-CoA reductase inhibitors have been shown to reduce hepatic stellate cell proliferation and collagen production and decrease oxidative stress and hepatic vascular tone in cirrhotic patients. Therfore, the aim of the present study was to examine whether the lipid lowering agents atorvastatin (Ato) or rosuvastatin (Ros) would prevent experimentally-induced acute or chronic hepatic damage in rats. Methods: Liver cirrhosis was induced by thioacetamide (TAA, 200 mg/kg, I.P.) twice a week, for 12 weeks. Acute damage was induced by two consecutive TAA injections (200 mg/kg in a 24 h interval). Rats were treated concurrently with TAA only or TAA and either Ato or Ros daily by nasogastric gavage. Another group was treated with TAA+pentoxifyline (PTX), an agent with known antifibrotic effect through a different mechanism and served as positive control. Results: Presented in the Conclusions: The lipid lowering agents used in our study had no effect on the development of acute or chronic hepatic damage in rats or on oxidative stress induced by TAA. Purpose: The development of hepatic fibrosis in patients with chronic liver disease increases the risk of liver cancer. The present study was conducted to determine whether an easily performed myocardial examination technique can be applied to the assessment of hepatic fibrosis. Strain Rate Imaging is a new method based on Tissue Doppler Imaging (TDI). The usefulness of Strain Rate Imaging in assessing the degree of hepatic fibrosis was evaluated. This time, it mede comparative study with Fibroscan in 11 cases. Methods: Strain Rate Imaging was performed using a diagnostic ultrasound system (Aplio TM , Toshiba Medical Systems Corporation, Tochigi, Japan) in a total of 47 subjects:25 in the chronic hepatitis group, 12 in the cirrhosis group, and 10 in the normal control group. TDI-Q, the Tissue Doppler analysis software installed in the Aplio system, was used for analysis. Measurement was performed five times from the epigastrium, with the ROI size set to 10 mm and the derivative pitch to 3 mm.