These developments, at least partially, were facilitated by the availability of a compiled dataset of known recoded genes collected together in the Recode database (http://recode.genetics.utah.edu), which was initially launched 9 years ago (46, 47) . To facilitate further development of computational tools for the prediction of recoded genes in the ever faster growing body of sequence data, as well as to provide bench researchers with upto-date information on recoding, an efficient means of Recode database population and annotation are now required. In this article, we describe the incarnation of the database, Recode-2. The major advances of Recode-2 (hosted in a new location http://recode.ucc.ie) over previous versions include a new web design allowing enhanced visualization of stimulatory signals, a uniform RecodeML format for the annotation of recoded genes, and a significantly larger number of entriesincluding many recently identified cases-that altogether have more than doubled the size of the database since its last published update.