Published data sets were obtained from four siRNA screens for influenza A modulators that used viral replication as an end point assay [4] [5] [6] [7] . Candidate hits in our screen were queried for behavior as regards viral replication. Hits that modulated viral replication greater than 1.5 standard deviations were assigned to functional classes. In cases were hits showed multiple phenotypes the strongest phenotype was used for classification.