Family Q had infected members across three generations and two genotypes/subgenotypes. In 2006, the grandmother (Q1W) and grandson (Q3M) were infected with CD1 recombinant while father (Q2) and granddaughter (Q3F) had mixed infections of genotype C2 and CD1 recombinants. In 2007, the same genotypes were detected in all family members except that the granddaughter (Q3F) had an HBV DNA level below the detection limit of the nested PCR assay.