The mt protein inventory is dynamically changed depending on the cellular state, tissue type, and species [11, 20] . For example, the compositions of mt proteins are different across various tissues and organs in mice [21, 22] and changed by fermentation states in yeast [18] or environmental stresses in plants [23] . Additionally, in humans, dynamic changes in the mt proteome affect the functional organizations of mt proteins and disease susceptibilities [24] . Genetic or biochemical abnormalities in mitochondria caused by complete or partial mtDNA depletion have been linked to a wide range of human diseases including metabolic syndrome, neurodegenerative disorders, mitochondrial myopathy, and cancer [12, 25] . We have previously reported that mtDNA depletion can lead to impairments of glucose metabolism [26] , insulin signaling [27] , and apoptosis [28] . However, the changes of the mt protein functional network in response to mt dysregulation remain to be revealed.