There is a need for experimentation in more realistic discrete modeling, since the lattice type of discrete modeling is understood to skew in favor of propagation, as discussed by Rhodes and Anderson [20] and Haraguchi and Sasaki [21] . Others such as Eames and Keeling [22] and Edmunds et al. [12] have explored the use of networks to model interactions between infectable entities, and Ferguson et al. [23] and others have called for more balance in realism for epidemiology models. Since EpiFlex was completed, Lloyd-Smith et al. [17] have shown the importance of superspreading in disease transmission for the SARS epidemic. EpiFlex is designed to take these issues into account.