Using a logistic regression model involving age, gender, APACHE II, SOFA, HMGB-1, sRAGE and RAGE, we found that the only variables that modified the probability of the patient having a fatal outcome were SOFA (P = .013) with a relative risk of surviving of .347 (CI: .151-.797); and sRAGE (P = .05) with a relative risk of surviving of .998 (CI: .998-1) ( Table 3 ).