An early murine study demonstrated that cationic lipidmediated transfer of the Na + ,K + -ATPase gene ameliorated high-permeability pulmonary edema [59] . Electroporationassisted gene transfer of plasmids encoding for Na + ,K + -ATPase reverses endotoxin-induced lung injury [60] . Th e lipoplex-delivered IL-10 gene decreased lung and systemic organ injury induced by cecal ligation and puncture in mice [61] . Systemically administered cationic polyethyleni mine polyplexes incorporating indoleamine-2,3-dioxyge nase transduced pulmonary endo thelial cells and decreased lung ischemia-reper fusion injury [62] .