Only recently has it become possible to use the DNA Signature Pipeline to predict signature candidates for draft genomes. This capability is due to the invention of software for multiple sequence alignment of draft genomes with at least one completed full genome. WGASA was developed by David Hysom, Chuck Baldwin and Scott Kohn in the Computations directorate at Lawrence Livermore National Laboratory. They designed the software in close communication with members of our bioinformatics team, and it is tailored for our needs of generating diagnostic and forensic pathogen signatures.