We can now compare these tables directly, thereby allowing gene-by-gene comparison of human disease phenotypes and mouse genetic phenotypes. Tables 6 and S3 are comparisons of the genes that overlap between the human and mouse gene lists (Table S1 and  Table S2 ) showing mouse gene symbols and their human orthologs. Table 6 is a small subset of selected gene-phenotype cross species comparisons. Even though in some cases the human studies have not been replicated, there is often a striking concordance between human disease phenotypes and mouse genetically determined phenotypes. For example, the human gene inhibin alpha (INHA) has been associated with premature ovarian failure [32] , and shows mouse phenotypes of abnormal ovarian follicle morphology, female infertility, and ovarian hemorrhage [33] , among other phenotypes relevant to human disease. Similarly, in humans the engrailed homeobox 2 gene (EN2) has been associated with autistic disorder [34] while the comparison to mouse En2 has genetic mutations involved in abnormal social integration, spatial learning, and social/consecutive interaction, among others [35] . Importantly, the few mouse studies highlighted above, and many found in the main table S3, were published after the corresponding human genetic population based epidemiological studies. Given concerns of false positives and publication bias in human genetic association studies, direct comparisons to related mouse phenotypes may provide supporting evidence that a given gene may be relevant to a specific human disease phenotype. Table S3 [36] is a full listing of the 1104 shared genes between the human disease and mouse phenotype summaries.