Evidence-Based Complementary and Alternative Medicine 3 Quercetin tends to downregulate the ethanol-induced expression of glutathionine peroxidase 4 (GPX4). Furthermore, it tends to reduce the expression of SOD2 induced by ethanol, to downregulate the expression of Gadd45b at the presence of ethanol, which could permit to explain DNA demethylation associated with the upregulation of gene expression in experimental ALD [23] .