Glypican 3 and agrin expression in hepatocellular carcinoma and cholangiocellular carcinoma: A immunochemistry study N. Gursan * , H. Balta, B. Gundogdu * Ataturk University, Medical Faculty, Erzurum, Turkey Objective: Glypican 3 (GPC3), which plays a role cellular growth, differentiation and migration is one of members of glypican family. Although GPC3 expression in the liver, glypican upregulation of the vast majority of tumors are available. Agrin is found the surface on the cells and the extracellular matrix, the micro-vessels Method: In this study, formalin-fixed, paraffin-embedded surgical specimens from 20 patients with hepotocellular carcinoma and 20 patients with cholangiocellular carcinoma diagnosed between 2000 and 2011 years in Ataturk University, Faculty of Medicine, Department of Pathology were studied with immunohistochemistry Agrin and GPC3. Results: We detected agrin in around bile ducts and blood vessels within the portal areas in the normal liver. İn the malignant hepatocellular carcinoma (HCC) is seen in a dramatic increase in the quantity of agrin. GPC3 immunpositivity showed in %85 of HCC and %15 of cholengiocellular carcinoma. Agrin immunpositivity showed in %95 HCC and %50 of cholangiocellular carcinoma. Conclusion: GPC3 and Agrin, that is useful in early diagnosis of HCC cases; cholangiocellular carcinoma, or not enough was understood to be very limited.