UVGI has been demonstrated to be effective for the disinfection of drinking water and wastewater (Sykes, 1965; Angehrn, 1984; Lazarova et al., 1999; Craik et al., 2001; Lazarova and Savoye, 2004; Wu et al., 2005) and for hospital air disinfection as a method for controlling airborne infectious disease (Macher et al., 1992; Nardell, 1993; CDC, 1994; Gorsuch et al., 1998; Miller and Macher, 2000) . This study found that UVGI treatment did not affect the filter aerosol penetration, filter airflow resistance, or physical appearance of the FFRs. Throughput capability of a method similar to the one in this study is benefited by a relatively short ir-radiation time (30 min); however, it is limited by the available working surface area of a biosafety cabinet equipped with a UV-C source or other area being irradiated by a UVGI source. No known health risks to the user were identified.