The search for biomarkers of sepsis outcome is an intense field of clinical research. Several new potential markers were assessed and validated by different teams who published their reports in the journal in 2011. An early rise in circulating endothelial protein C was found to be associated with a high mortality [23] . This finding confirms the activation of coagulation at the initial stage of sepsis, and suggests a pathogenetic role for endothelial protein C in the pathway.