The membrane reorganization taking place during the acrosome reaction involves an additional change of high functional significance: the sperm becomes capable of fusing with the egg. Although IZUMO has been shown to be necessary for sperm-egg fusion [55] , the molecular mechanisms conferring fusogenic ability to sperm are not well understood. Membrane microdomains and their resident molecules have been implicated in processes requiring cell-cell fusion such as invasion [56, 57] . With respect to the molecules depicting a different inmmunofluorescence pattern after the acrosome reaction, while FLOT2 has been positively correlated with metastatic processes [58] , GM3 has been negatively associated with cell motility and invasiveness [59] . In the sperm, we can speculate that the presence of GM3 is associated with a nonfunctional equatorial segment and that GM3 modification or loss may be needed for the sperm to acquire the ability to fuse with the egg. Taking into consideration that IZUMO has a direct role in sperm-egg fusion as suggested by the null mutant phenotype [55] , the putative participation of those regions where IZUMO localized after the acrosome reaction in sperm-egg fusion should be reanalyzed. Global Expression Profiling in Epileptogenesis: Does It Add to the Confusion? Since the inception of global gene expression profiling platforms in the mid-1990s, there has been a significant increase in publications of differentially expressed genes in the process of epileptogenesis. In particular for mesial temporal lobe epilepsy, the presence of a latency period between the first manifestation of seizures to chronic epilepsy provides the opportunity for therapeutic interventions at the molecular biology level. Using global expression profiling techniques, approximately 2000 genes have been published demonstrating differential expression in mesial temporal epilepsy. The majority of these changes, however, are specific to laboratory or experimental conditions with only 53 genes demonstrating changes in more than two publications. To this end, we review the current status of gene expression profiling in epileptogenesis and suggest standard guidelines to be followed for greater accuracy and reproducibility of results. The understanding of epilepsy as a complex interaction between numerous excitatory and inhibitory neuronal connections influenced at the molecular level rightly brings about focus to global changes in the entire transcriptome in the epileptogenic process. Annotating the individual genomic changes at specific time points delivers only a snapshot of a much larger process. The development of global gene expression profiling platforms has revolutionized molecular biological research, allowing vast amounts of information to be identified, catalogued and measured. Genomic changes are seen in concert giving the potential for a broader understanding of the disease process.