Even though consequences were less dramatic than initially feared, the 2009 influenza A/H1N1v pandemic has caused a significant burden of disease worldwide, especially in the pediatric population [6] [7] [8] . Higher attack rate was observed among children, causing important overload in outpatient and emergency departments [11] as well as in PICU [22] . Unfortunately, our study was not designed to assess the epidemiological impact of influenza A/H1N1v infection over the whole pediatric population of Brussels. Moreover, by selecting only laboratory confirmed infections, we underestimated the number of hospitalized cases, especially since diagnosis confirmation by PCR was no more routinely performed at the end of the epidemic. However, we were able to notice an important pediatric burden of disease in Brussels, as illustrated by an increased rate of outpatients visits of 18% during the epidemic period compared to the three previous years and a high rate of PICU occupation by influenza A/H1N1v infected patients (8% during the peak of epidemic). It would have been of interest to compare the rate of hospitalization related to H1N1 with those registered for seasonal flu during the 3 previous years but these data were unfortunately not available.