CD40 -(TNFRSF5, B-cell surface antigen CD40). The loss of Normalized Shannon Entropy gives us several markers that indicate a de-differentiation from a epithelial basal phenotype and an increasing loss of control of cell cycle regulation (due to uncoordinated upregulation of CDK4, CDK7, CCNG2 with their functional partners). This poses the question: What can we observe while looking at the genes that most positively correlate with the loss of Normalized Shannon Entropy? We observe, second on the ranking of all samples, a probe for CD40 (TNFRSF5, B-cell surface antigen CD40), BX381481 with a Spearman correlation of 0.7616. Loss of CD40 expression has been previously reported in prostate cancer and it is the object of a study that attempts to establish dendritic cell gene therapies [504, 505, 506, 507, 508, 509, 510, 511, 512, 513, 514, 515, 516, 517, 518, 519, 520, 521, 522] . We will continue discussing CD40 in the following subsection in concert with other genes.