Objective: Six different, rarely seen tracheobronchial lesions, taken by bronchoscopy as small fragments were discussed with an emphasis on morphological findings and differential diagnosis. Results: Six patients were men and two patients were women with an age range of 50 to 70 years. Most of the lesions were symptomatic and discovered as small masses by bronchoscopy. The tracheobronchial lesions varied from polypoid, nodular, well-demarcated, fragile masses to nodular thickenings. Microscopically, a polyp composed of a fibrovascular stroma with scattered mononuclear inflammatory cells was compatible with fibroepithelial polyp. Mature adipocyte proliferation in two cases, S-100 and CD68 positive polygonal or ovoid cells with abundant eosinophilic, granular cytoplasm having small, hyperchromatic nuclei, smooth muscle actin and desmin positive spindle cells in interlacing fascicles within a myxoid and collagenous stroma with mononuclear inflammatory cells, CD34 and CD31 positive thin-walled vascular channels, filled with red blood cells and S-100 positive spindle cells having palisading of wavy nuclei in two cases, located in the submucosa were main findings of lipoma, granular cell tumor, inflammatory myofibroblastic tumor, cavernous hemangioma and schwannoma, respectively. Conclusion: Tracheobronchial biopsies, even with small fragments of lesions can allow to render rare specific histopathological diagnoses, some of which need to be confirmed by immunohistochemistry. Objective: Small cell lung carcinomas (SCLC) are aggressive neoplasms that give very early distant metastases. Matrix metalloproteinases (MMPs) are a family of endopeptidases which degrade extracellular matrix and modulate cell adhesion, playing a crucial role in cancer cell invasion and metastasis. The aim of the present study is to investigate the immunohistochemical expression of MMP-2, MMP-9 (type IV collagenases) and MMP-1 (interstitial collagenase) in patients with SCLC. Method: Formalin-fixed, paraffin-embedded lung biopsy specimens from 40 patients with SCLC (M:F=29:11, median age=66.7) were immunostained for MMP-1, MMP-2 and MMP-9 (anti-MMP-1 polyclonal antibody, anti-MMP-2 72 kDa Collagenase IV antibody, anti-MMP-9 92 kDa Collagenase IV antibody, Spring Bioscience). Results: Immunohistochemical expression of MMPs was detected in the cytoplasm of neoplastic cells. Immunoreactivity was designated positive when >10 % of neoplastic cells were stained. Overall, MMPs were expressed in the majority of SCLC. Specifically, MMP-1 was positive in 90 % (36/40), MMP-2 in 87.5 % (35/40) and MMP-9 in 82.5 % (33/40) of SCLC. Non-neoplastic lung parenchyma did not stain for MMPs. Conclusion: The majority of SCLC express immunohistochemically MMP-2, MMP-9 and MMP-1. Given the role of MMPs in cancer progression and metastasis, their expression in SCLC may contribute to their aggressive course. Objective: Number of pulmonary adenocarcinoma (ADC) patients incresease. Treatment of non-small cell pulmonary carcinoma depends of its histological type in era of target molecular therapy particulary of ADC: Diagnosis of ADC is established on small-sized pulmonary biopsies obtained on bronchoscopy and by transthoracic needle pulmonary biopsy. The aim of this study was to evaluate optimal panel of monoclonal antibodies in diagnosis of pulmonary ADC on small-sized biopsy pulmonary samples. Method: Analysis of 50 small-sized biopsy pulmonary samples. Diagnosis of ADC was established on hematoxillyn-eosin stained (H&E) samples and confirmed immunohistochemicaly by Thyreoid Transcription Factor-1 (TTF-1), Napsin-A, Surfactant B and Cytokeratin7 (CK7). Descriptive statistical method (%) was used. Results: TTF-1 specificity was 86 %(43/50), Napsin-A-82 %(41/50), SurfactantB -56 %(28/50) and CK7-90 %(45/50) in ADCs. Two monoclonal antibodies were positive in 24 % (12/50) ADCs, one of them was necessary TTF-1 or Napsin-A. Three monoclonal antibodies were positive in 40 %(20/50) and 4 in 36 %(18/50) ADCs, respectively. There is not statistical significans in number of monoclonal antibodies for diagnosis of ADC. Conclusion: No one monoclonalantibody is specific for one histological type of carcinoma and its origin. TTF-1, Napsin-A, SurfactantB and CK7 belong in optimal panel for diagnosis of pulmonary adenocarcinoma.