Limited research has focused on B cells and the specificity of antibodies they produce in cancer. Promotion of cancer development by the creation of a pro-inflammatory environment [14, 15] and anti-tumor functions by activating mature T cell responses [16] have been proposed as potential roles for B cells in animal models of cancer. While there may be host immune responses to malignancy following immunization [17] , a variety of mechanisms involved in tumor escape have been described and understanding this complex relationship between immunosurveillance and tumor escape in patients is key to the design of effective immunotherapies [18, 19, 20, 21] .