We have listed above some of the genes gene associated to the M phase of mitotic cell cycle and associated references which are either to current research in melanoma and/or its biological function. We now list other genes which have been associated with the term 'cell proliferation' by GATHER. These genes are: ARPC1B [252] , ARPC2 (which, together with SPP1, is also in the novel 5-biomarker panel of Kashani-Sabet et al. [253] ), BCCIP (BRCA2 and CDKN1A-interacting protein)/P21-and CDK- Figure 10 . Expression of a probe for CLDN1 (Claudin 1) (y-axis) as a function of a probe for Aquaporin 3 (x-axis). Other members of the aquaporin family of proteins have a similar behaviour. AQP3, together with CLDN1 are key components of the tight junction complexes of the epidermis and their joint loss of expression seem to be related to a transition to a more malignant phenotype. We use the same color coding as Figure 9 . doi:10.1371/journal.pone.0012262.g010 associated protein 1) [254] , BST2/Bone marrow stromal antigen 2/Tetherin [255] , CCL3/MIP-1alpha [256, 257, 258] , CCT4, CDCA5/Sororin [259, 260, 261, 262, 263] , CENPF/Mitosin [264] , CXCL1/chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285] (in uveal melanoma see [286] ), CXCL10 [256] , FLT1/VEGFR1 [287, 288, 289, 290, 291, 292, 293, 294, 295, 296, 297, 298, 299] , FTH1/Ferritin Heavy Chain [300, 301, 302] (which may indicate a necessary condition for the mainainance of iron sequestration and suppression of reactive oxygen species accumulation [303] ), FPRL1, LIG3/DNA Ligase 3 [304] (which, together with XPA and ERCC5 is associated to DNA repair in ionizing radition studies [305] ), MCMDC1, PSEN2, NRP2/Neuropilin 2/Vascular endothelial cell growth factor 165 receptor 2 [306, 307, 308] , SEMA6A (a member of the Semaphorin family, of increasing importance in cancer research [309, 310, 311] and in particular due to its observed upregulation in undifferentiated embryonic stem cells [312] ), SLAMF1/CD150 (a marker associated with hematopoietic stem cells [313] ), SPP1/Osteopontin (which, together with ARPC2, is also in the novel 5-biomarker panel of Kashani-Sabet et al. [253] ) [206, 207, 208, 209, 210, 211, 212] [206,207,208,209,210, 211,212,214,215,216,217,218,219,220,221,222,226,314,315,316,-317,318,319,320,321,322,323,324,325,326,327,328,329] , STK6 [230, 330] , and WARS/Tryptophanyl-tRNA synthetise [331] . Figure 11 shows a heat map of discussed gene probes annotated with functions on cell proliferation.