Among non-protein coding, microRNAs [735] are gaining acceptance as key players in several cancers [736, 737, 738] (including prostate cancer [739, 740] ), but the so-called ''long noncoding RNAs'' [741] are also gaining a place in the scenario of cancer biomarkers (see [742] , and [743, 744, 745] ). We thus turned our attention to these probes that have been annotated as ''nonprotein coding'' and we highlight some of them that have very high correlation values with the Normalized Shannon Entropy in True et al's prostate cancer dataset. In particular, the probes for MALAT1/ MALAT-1 [742, 746, 747, 748, 749, 750, 751, 752, 753, 754, 755, 756, 757, 758] have a very conspiquous position (See Figure 20) . They located very closely to other protein coding biomarkers that have also lost expression and have been discussed in this work like SFPQ, CD40, BRCA1, and TP53 (see Figure 16 ). MALAT1 has been recently pointed as a biomarker in primary human lobular breast cancer as a result of an analysis of over 132,000 Roche 454 highconfidence deep sequencing reads [749] . An international team, searching on thousands of novel non-coding transcripts of the breast cancer transcriptome, has been able to identify more than three hundred reads corresponding to MALAT1 [749] . This is a noncoding RNA which was identified in 2003 in non-small cell lung cancer, was shown to be highly expressed (relative to GAPDH) in lung, pancreas and prostate, but not in other tissues including muscle, skin, stomach, bone marrow, saliva, thyroid and adrenal glands, uterus and fetal liver [758] . MALAT-1, also known as NEAT2, is considered to be ''extraordinarily conseved for a noncoding RNA, more so than even XIST'' [754] . Our results indicate that the reduction of expression of some non-coding RNAs, in particular of MALAT-1, and SNORA60 with respect to their normal expression in prostate, as well as the upregulation of SNHG8 and SNHG1 should be monitored as useful biomarkers to track disease progression.