Background: It has not been known that the hemodynamic effect of a portal hypertension for splenomegaly or esophageal and gastric variceal formation. This study was performed to access the parameters of doppler ultrasonography associated with splenomegaly or varices in patients with cirrhosis. Patients and Methods: From May 2007 to May 2008, 144 cirrhotic patients were performed the doppler ultrasonography. 91 of these patients were accessed the severity of varices endoscopically. The three dimensional volume of spleen was measured from a length, width and thickness on sonography. Results: The splenic volume (415.2ml vs 505.6ml, p=0.048) and blood flow of main portal vein (12.6cm/s vs 15.1cm/s, p=0.012) were statistically significant different in alcoholic (38/144) and non-alcoholic (105/144) cirrhosis groups. The splenic volume (600.1ml vs 384.4ml, p=0.001), damping index (0.52 vs 0.38, p=0.024), and blood flow of main portal vein(12.5cm/s vs 15.7cm/s, p=0.006) were statistically significant different in esophageal variceal groups (55/91) and non-esophageal variceal groups(36/91). The only splenic volume (669.4 ml vs 461.7 ml, p=0.004) were statistically significant different in gastric variceal groups (24/90) and non-gastric variceal groups (66/90). The hemodynamic parameters venous ammonia and CFF at baseline and after one month of treatment with lactulose. MHE diagnosed by abnormal psychometry and/or P300ERP.Response defined by normalization of abnormal test parameters. Results: MHE diagnosed in 35(58%) patients. Of 35 patients 26 (74%) had both abnormal psychometry and P300ERP whereas30 (86%) alone had abnormal psychometry, 31 (89%) had abnormal P300ERP.CFF was <39Hz in 28(80%) patients. MHE recovered in 55% with treatment and CFF >39Hz was seen in 22(69%) of 32 patients. CFF sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy before and after treatment is shown in table. Conclusions: Critical flicker frequency is a simple and accurate test without any age or literacy dependence for the diagnosis and recovery of patients with MHE. Background/Aims: Endoscopic injection of N-butyl-2-cyanoacrylate (Histoacryl) is an effective treatment of varix bleeding. But nontarget embolizations and septicemia are unwanted complications. We evaluate the risk factors for complications. Methods: Thirty-three patients with esophageal or gastric varix bleeding received endoscopic Histoacryl therapies (54 procedures). Baseline varix size, CTP score were checked. Serum leukocyte, blood culture and body temperatures were repeated checked within one week after procedure. Average volume of Histoacryl per each session was 1.6 mL, and dilution volume ratio of Histoacryl/lipiodol was 1/1 or 1/2. Results: Average of CTP score was 8.0 ± 1.7. Three cases of septicemia were correlated with CTP score rather than session frequency or injection volume. Two cases of systemic embolizations (pulmonary and splenic arterial embolism) were correlated with high lipiodol dilution ratio (1/2) and lipiodol volume rather than Histoacryl volume or CTP score. Conclusion: CTP score, lipiodol volume and dilution ratio of Histoacryl/lipiodol were significant risk factors for complications.