CyDs have been reported to interact with cell membrane constituents such as cholesterol and phospholipids, resulting in the induction of hemolysis of human and rabbit red blood cells at high concentrations of CyDs [28] [29] [30] . In addition, CyDs are well known to disrupt liposomal membranes, depending on CyD cavity sizes and membrane components [31, 32] . Then, we evaluated the interaction of CyDs with AF-liposomes These results suggest that the interaction of γ-CyD and HP-CyDs with AF-liposomes was weaker than that of α-CyD and DM-β-CyD.