According to our analysis based on 199 HPeV VP1 available sequences, these viral species diverged from their most recent common ancestor (MRCA) at the year 1600 (95% HPD [1427-1733]) ( Figure 1 , Table 2 ). Moreover, and focusing on the two most recently isolated types (HPeV7 [19] , HPeV8 [20] . Taken together, we suggest that the genetic diversity of the currently circulating HPeV types has arisen around 400 years ago (Figure 1 ).