Objective: Glioblastoma is the most common malignant tumor of central nervous system in adults which characterized by malignant pleomorphic astrocytic cells with marked nuclear atypia, mitotic activity, necrosis and/or microvascular proliferation. Glioblastoma may manifest at any age but usually affects adults especially older than 50 years. In this case, we present a pediatric glioblastoma case because it has seen rarely under 20 years and it is so important owing to its prognosis. Method: An 11-year-old boy has had headache for 20 days. According to radiological imagings 23×20 mm in diameter infiltrating mass has seen in temporal lobe contains 15× 7 mm in diameter cystic component and contrast enhancement was noted. Clinically grade 3 astrocytoma has thought primarily and he has been operated. Results: In microscopic examination nuclear atypia, mitotic activity and microvascular proliferation has seen without necrosis. Objective: Gliosarcomas are biphasic neoplasms composed of a glioblastoma admixed to a sarcomatous component with different lines of differentiation. Histogenesis of these tumors is still discussed. Our objective is to specify pathological characteristics of this neoplasm its related to or not to glioblastoma. Method: 3 cases of gliosarcomas diagnosed in our department of pathology. Clinical, radiological, therapeutic and follow-up data were reviewed. Histological features and immunohistochemical results were also established. Results: 3 female patients with a median age of 46 years (ranging 30-69 years). intracranial hyperpressure and paralysis are main symptoms. The brain imaging showed frontal, fronto-parietal and intra ventricular expansive process, respectively. Microscopically, a biphasic pattern, with anaplastic astrocytic cells alternated with malignant mesenchymal areas, demonstrating a fibrosarcoma pattern, in two cases and rhabdoïd pattern in one case. Immunohistochemical stain confirmed the diagnosis of gliosarcoma in each case. Patients were treated by surgical excision; One patient was lost on follow-up. One patient died by postoperative complications. Conclusion: Clinical, radiological and follow-up features of gliosarcomas share great similarities with glioblastomas. Histopathological, histochemical and immunohistochemical studies are helpful in accurate diagnosis. Cytogenetic and molecular data support a monoclonal origin for these tumors. Objective: Case of biphasic synovial sarcoma of nerve in a 59 year-old female located between flexor muscles and radial diaphysis and adherent to median nerve and ulnar artery is presented. Method: Tissue was fixed in formalin, embedded in paraffin and stained with Haematoxylin and Eosin. Periodic Acid-Schiff stain without diastase pre-digestion was obtained. Ventana antibodies were employed: TTF-1, ER, EMA, S100, CK 14, CK 7 and MNF 116. SS18-SSX fusion gene transcript was detected with conventional RT-PCR and qRT-PCR. Results: Macroscopically nodule had smooth circumscribed borders, grey-yellowish colour and measured 3,7×3×2,5 cm. Histologically it was delimited by a dense sclero-hyaline capsule and constituted of numerous glands lined by one layer of cuboidal-columnar cells showing eosinophilic cytoplasm and round to ovoid nuclei with a single small nucleolus. They contained dense eosinophilic strongly PAS and EMA positive material. Glands were immersed within tightly packed spindle cells. Mitoses were scanty. Necrosis was absent. EMA strongly stained most of the glandular as well as scanty spindle cell elements. Chromosomal reciprocal translocation t (X; 18) with positive signal for SS18-SSX1 transcript was seen. Conclusion: Synovial sarcoma of nerve is a rare condition that has to be distinguished from histologically similar lesions.