Objective: Systemic amyloidosis is a rare disorder, characterized by extracellular accumulation of Congo-red (CR) positive fibrillar amyloid protein deposits. The kidney is the most commonly affected organ by systemic amyloidosis. CR staining which increases the positive birefringence of the weakly birefringent unstained amyloid. In this study we investigated potential power of digitally reinforced birefringence of routine Hematoxylin-eosine (HE) slides on the renal biopsies.