Table S11 Analysis of interspecies interactions. VZV core and noncore baits were analysed for Y2H interactions against prey libraries of VZV, HSV-1, mCMV, EBV and KSHV. The species of the interacting prey is included, in addition to whether it was a core or a noncore protein. Table S12 M51 interactions tested by CoIP. Interactions observed with mCMV M51, or with other orthologs of M51, with a subset of interaction partners from the Y2H analysis. Tegument proteins, and other virion components, were determined based on whether they were reported to be present in the CMV virion [59, 60] .  Insertion/Deletion Polymorphism of Angiotensin Converting Enzyme Gene in Kawasaki Disease Polymorphism of angiotensin converting enzyme (ACE) gene is reported to be associated with ischemic heart disease, hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy. In this study, we investigated the relationship between Kawasaki disease and insertion/deletion polymorphism of ACE gene. Fifty five Kawasaki disease patients and 43 healthy children were enrolled. ACE genotype was evaluated from each of the subjects' DNA fragments through polymerase chain reaction (PCR). Frequencies of ACE genotypes (DD, ID, II) were 12.7%, 60.0%, 27.3% in Kawasaki group, and 41.9%, 30.2%, 27.9% in control group respectively, indicating low rate of DD and high rate of ID genotype among Kawasaki patients (p<0.01). Comparing allelic (I, D) frequencies, I allele was more prevalent in Kawasaki group than in control group (57.3% vs. 43.0%, p<0.05). In Kawasaki group, both genotype and allelic frequencies were not statistically different between those with coronary dilatations and those without. ACE gene I/D polymorphism is thought to be associated with Kawasaki disease but not with the development of coronary dilatations. Kawasaki disease is an acute systemic vasculitis and its diagnosis is made on clinical features. Main complication of the disease is coronary artery lesion that may result in myocardial infarction or sudden death. Coronary artery aneurysms or ectasia develop in approximately 15-25% of untreated children (1) . Since the intravenous immune globulin (IVIG) and aspirin therapy have been introduced, its mortality rate has decreased to 0.1%, but cardiac sequelae continues to occur in about 13% of Kawasaki disease patients (2) .