We use a compartmental model for multistrain disease spread with cross immunity and antibody-dependent enhancement, previously studied in a single, well-mixed population (Bianco et al. 2009 ). In this model, individuals can develop a primary infection with any of the serotypes. Immediately after recovering, the individual experiences a period of temporary partial cross immunity to all other serotypes. When the cross immunity wears off, immunity to the primary infecting strain is retained, but the individual can develop a secondary infection with a different serotype. Infectiousness of the secondary infectives is increased due to antibody-dependent enhancement. After the secondary infection, complete immunity to all serotypes is assumed. A flow diagram for the single patch model with two serotypes is shown in Fig. 1 for simplicity, but we present results here for all four serotypes. We extend the model to two spatially distinct patches, which are coupled by linear migration terms. For two patches (indexed by q) and n strains (n arbitrary), the model is as follows: