A-002 12 Imaging scientists are similar to the fly floating in a swimming pool described by Richard Feynman: they imagine the real world from the few waves that reach their small niche. Biological time scales range from fractions of seconds to evolutionary ages; biological spatial dimensions from atomic scales to tens of centimeters. Not one single technique can produce images spanning more than three temporal or spatial orders of magnitude. To reach further precision, either a priori information must be introduced in the imaging method, or several imaging techniques must be combined through co-registration. Here we give one example for each approach.