It is possible for lipid rafts to modulate signaling in a general way by affecting the activities of signaling molecules involved in multiple pathways. These include, for example, the pleiotropic src kinases (Arcaro et al., 2007) with effects on the PI3K-Akt signaling pathway. Other raft-localized signaling proteins include the epidermal growth factor receptor (EGFR), which associates with caveolins (Couet et al., 1997) and is involved in diverse processes including cell cycle regulation, endocytosis, and the MAPK cascade (Oda et al., 2005) . This has led to the concept of the signalosome, containing interacting components of signaling pathways (e.g., EGFR) within lipid rafts along with other scaffolding proteins, such as caveolins, and sequestering the complex from other interacting proteins that may disrupt the signaling process. A prime example is the CD40 signalosome associated with cell growth in B cell lymphomas (Pham et al., 2002) .