Methods: Among 507 patients who received resection from January 1996 to August 2006, 58 patients had a radiologically detected multiple HCC. Patients with multiple HCC were divided into: group A, patients treated with one-block resection (n=40) and group B, patients with multiple-site resection or combined resection and RFA (n=18). Results: In group B, 6 received multiple-site resection and 12 underwent combined resection and RFA. The clinicopathological variables and postoperative complication rate were not significantly different between the two groups. The 5-year disease-free survival rates for group A and B were 24.1% and 18.3%, respectively (p=0.386). The overall survival rates were also not significantly different (36.9% vs. 39.4%, p=0.528). The multivariate analysis revealed that radiological tumor number 3, Edmondsons-Steiner grade (III-IV) and indocyanine green retention rate at 15 minutes> 10% were adverse prognostic factors for overall survival. Conclusions: Active treatments including multiple-site resection and combined resection and RFA showed similar treatment outcomes compared with one-block resection in patients with multiple HCC. The prognosis after treatment was associated with tumor number, tumor grade and ICG R15. Background: Nasopharyngeal carcinoma (NPC) is endemic to southern China. Mortalities are mostly associated with secondary metastases. Novel treatments for NPC metastases are thus urgently needed. We aim to test the efficacy of a physiologically stable gold compound, gold (III) meso-tetraarylporphyrin 1a (gold-1a), in treating intrahepatic NPC metastasis in athymic mice. Methods: Twenty million of C666-1 human NPC cells were injected into the livers of athymic mice to induce primary tumors. Gold-1a was administrated by intraperitoneal injection. Survival times, tumor volumes and degrees of metastasis of the animals were evaluated. Intratumoral microvessel density was determined by immunohistochemical staining for CD34. Tube formation by MS1 mouse endothelial cells were conducted with an in vitro angiogenesis assay kit. Gene expression level was determined by semi-quantitative reverse transcription-polymerase chain reaction. Cell proliferation was performed by methylthiazolyldiphenyl-tetrazolium bromide assay. Result: Gold-1a prolonged the survival and inhibited intrahepatic and lung metastasis of the tumor-bearing animals. The compound induced tumor tissue necrosis and reduced tumor microvessel formation. In in vitro studies, gold-1a inhibited tube formation and proliferation of MS1 cells, and downregulated the expression of stanniocalcin 1 (Stc1), which plays roles in angiogenesis. Furthermore, our preliminary data showed that overexpression of Stc1 in MS1 cells rescued cells from gold-1a-induced death. Conclusion: Gold-1a is a novel anticancer agent that prolongs survival of the NPC metastases-bearing mice. It inhibits intrahepatic and lung metastasis in vivo and inhibits angiogenesis in vitro, in part via downregulation of Stc1. 