Some pharmaceutically relevant properties of the new designed agonist derivatives as well as the original GW409544 compound, such as the ''partition coefficient'' (logPo/w), ''van der Waals surface area of polar nitrogen and oxygen atoms'' (PSA), ''aqueous solubility'' (logS), and ''apparent MDCK permeability'' (PMDCK), were predicted by means of the QP program embedded in the ''Schrodinger2009 Software Package''. The results thus obtained are also listed in the Table 1 , respectively. Since PPARa and PPARc have a more spacious pocket (,1400 Å 3 ) than any other nuclear hormone receptors [37, 72] , it is quite natural that the agonist derivatives designed based on the two receptors by combining their three cores would have relatively large molecular weight (MW.500) and bulky volume, a trend quite similar to case in designing the inhibitors against the protein tyrosine phosphates (PTPase) [78] .