NucZip simulates the hybridization process, starting with potential nucleation sites and then proceeding to 'zip' in both directions. The NucZip algorithm (written by JB in Visual FoxPro) was implemented as a module (procedure) in the ConSort ß sequence analysis program. The procedure is relatively simplistic, and does not contain the thermodynamic and secondary structure analyses provided by more sophisticated programs such as Visual OMP TM 7.0.