Much of the effort in NADT development for respiratory diagnostics has focused on the detection of viruses, given the advantages of these techniques over conventional methods in terms of speed, sensitivity, and versatility for detecting this class of pathogens. Multiplex approaches for viral detection have become more common as technologies have improved (reviewed by [5, 7, 40, 41] ). In addition, NADTs have now become the gold standard for the detection of Mycoplasma pneumoniae [42] and Chlamydophila pneumoniae [43] and a useful addition to antigen testing for Legionella species [44] .