In Italy, measles vaccine (MV) was introduced in 1976 and routine administration of one dose of measles vaccine to all children aged ≥15 months was recommended since 1979. Combined MMR vaccines became available in the early 1990s and the two-dose schedule (first dose at 12-15 months and second dose at 5-6 or 11-12 years) was introduced in 1999 [5] . However, despite the existence of national recommendations, responsibility for implementation of measles vaccination activities lies within each of Italy's 21 regions. This has contributed to non uniform coverage across regions, with lower rates observed mainly in central and southern regions (including Lazio) with respect to northern regions [6] .