When comparing the data on the size and precise protein and lipid composition of lipid rafts it is important to bear in mind that they are determined not only by the type of detergent used, the conditions of the experiments and resolution of techniques applied, but also by the type of tissue and cells used for their isolation and visualization. This has to be taken into account when comparing the data and making conclusions about the physiological relevance of proteins detected in lipid rafts. From this point of view a systematic meta-analysis of existing data considering various experimental conditions, tissue specificity, and resolution of the techniques applied might provide a useful tool for understanding raft heterogeneity and for optimizing further research into this intriguing subject.