Intriguingly, large proportions of the identified antigens are involved in oxidative stress, drug resistance and iron acquisition. Furthermore, strong IgG response to many proteins known to be induced and/or required for C. albicans invasion of epithelial and endothelial cells is observed in both candidemia patients and noncandidemia controls, including all healthy individuals. Our findings provide new insights into commensal colonization and pathogenesis of C. albicans, as well as the characterization of potential serodiagnostic antigens and vaccine candidates.