We analyzed weights assigned by the experts working in different areas of medicine: epidemiologists and public health specialists (n = 43), laboratory specialists (n = 35) and clinicians (n = 8) ( Table 2) . Several criteria were assessed similarly across the groups (for example, the criteria ''Prevention'', median weight of ''8'', or ''Trend'', median weight of ''5''). At the same time, the criterion ''Incidence'' was seen as one of the most important by Need for medical treatment is established but currently no effective treatment is available or AMR limits treatment options AMR = antimicrobial resistance. Note 1. All criteria apply to the geographical settings where the prioritization is conducted; the time-frame applicable to the requested epidemiological data should be defined prior to the process initiation and depend on a frequency with which pathogens are planned to be re-scored. The RKI conducted re-scoring relevant for Germany using a time-frame of 5 years. Indicated numerical thresholds apply to a country where the prioritization process is conducted; when the prioritization is conducted in other geographical settings, different thresholds may need to be considered. Note 2. Event is defined as the occurrence of a disease that is unusual with respect to a particular time, place or circumstances. For certain infectious diseases one case may be sufficient to constitute an event (e.g. polio virus). Public health actions are any kind of targeted actions aiming to identify the nature of the event and/or to apply control measures in response to the event occurrence. *assessed against the total burden of infectious diseases. **assessed for each particular pathogen in question, e.g., for the criterion ''Treatment possibilities and needs'' it therefore refers to availability and adequacy of treatment for each case of an illness caused by a particular pathogen and does not take into account the incidence of illnesses or the availability of preventive measures. doi:10.1371/journal.pone.0025691.t001