We hypothesize that GDC-central proteins and proteins in DSs of PPI networks could represent potential candidates for therapeutic intervention, since targeting GDC-central proteins with drugs would have more significant impacts on the network than targeting proteins that reside in sparse and non-complex network regions and since the topology of a DS can enable quick propagation of drug effects through the entire network. Indeed, we find that the enrichment in drug targets of genes that are GDC-central or are in the DS (this is the union of the set of genes that are GDC-central and the set of genes that are in the DS) is 11.4% and it is statistically significant, with p-value of 1:3|10 {4 . Furthermore, the enrichment in drug targets of genes that are simultaneously GDC-central and are in the DS (this is the intersection of the set of genes that are GDC-central and the set of genes that are in the DS) is even higher, it is 31.7%; this enrichment is also statistically significant, with pvalue of 0. Hence, not only that each of the two concepts of topological centrality, GDC and DS, captures a statistically significant percentage of drug targets, but also when the two centralities are combined, the percentage of drug targets that they capture is significant and even higher.