We used finished sequence data generously provided by collaborators at the US CDC for 28 variola major genomes and 22 NN genomes from the Orthopox family. The sequence identities are provided in the Appendix. Since we did not have real draft data available, we developed a program to simulate draft sequence from finished sequence, based on guidance from two colleagues who have been involved in sequencing efforts and the finishing process in the Biology and Biotechnology Research Program at Lawrence Livermore National Laboratory. In outline, the draft simulator program randomly cuts a genome into contigs of a size randomly selected from an exponential distribution. Stochastic simulation also determines whether there are gaps or overlaps between contigs, as well as the size of the gap or overlap. Sequencing errors are also simulated.