Other Outcomes (TCM-SSD Scores, SAS Scores, 5-HT, BDNF, etc.) One trial [15] showed that there are no significant differences on TCM-SSD and SAS scores. One trial [12] showed that after 6 weeks of treatment, the serum level of 5hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) increased (P < 0.01) and the Interleukin-6 (IL-6) level decreased in both groups without significant difference between two groups, the cortisol (CORT) level reduced significantly in the DXP group compared to Maprotiline group. Other Outcomes (HAMA Scores, CGI Scores). One trial [10] showed significant benefit on HAMA scores decreased in favor of combination group after 6 (MD: 