The average number of genes expressed in specific tissues is about 5000. The proteome size of a specific tissue ranges from a few thousand to tens of thousands. Because a tissue contains diverse cells, the proteome size of one differentiated cell may be a few thousand. Because most proteome data are still unavailable and are confusing with the proteome containing post-translational modifications, transcriptome data from clustered EST can be used instead. The number of unique sequences of clustered ESTs from human breast tumors is 6501 [12] , so we estimated t=6500 as the average cellular proteome size of differentiated cells. With all the differentiated cells available, organism spatial structure can be constructed. Let z be the total number of cells in an organism.