Apart from compartmentalization within the lipid rafts, the amyloidogenic processing pathway was shown to be dependent on endocytosis (Ehehalt et al., 2003) . In addition to flotillin, caveolin-1 is responsible for partitioning of γ-secretase between the plasma membrane and endosomes and cells depleted of caveolin-1 had more γ-secretase localized within the clathrin-coated noncaveolar endocytic vesicles, although different caveolins have been shown to have different effects on APP processing (Nishiyama et al., 1999; Kapoor et al., 2010) .