Seasonality effects are still an open problem in the transmission of ILI diseases. In order to include the effect of seasonality on the observed pattern of ILI diseases, we use a standard empirical approach in which Population layer Short-range mobility layer Long-range mobility layer The short-range mobility layer covers commuting patterns between adjacent subpopulations based on data collected and analyzed from more than 30 countries on 5 continents across the world, modeled with a time-scale separation approach that defines the effective force of infections in connected subpopulations. The long-range mobility layer covers the air travel flow, measured in available seats between worldwide airport pairs connected by direct flights.