One question arises as to the use of high-resolution CT (HRCT) scans instead of conventional CT scans in detecting TIB patterns, as well as the effect of using HRCT scans in this process. Although HRCT scans appreciate detection of small nodular patterns, they have more noise and lungs might not be fully covered due to large gaps between slices (i.e., 10-30 mm). Furthermore, at our institution and in many other institutions, the protocol for acute pulmonary infection is 5 mm contiguous slice images of the chest without IV contrast, for which we adapted our CAD method. Nevertheless, the method we present is not data dependent and can be used for HRCT scans as well.