In a letter to Peter Guthrie Tait, Maxwell writes about the ''demons'': ''Is the production of an inequality of temperature their only occupation? No, for less intelligent demons can produce a difference in pressure as well as temperature by merely allowing all particles going in one direction while stopping all those going the other way. This reduces the demon to a valve. As such value him. Call him no more a demon but a valve like that of the hydraulic ram, suppose.'' (from [645] , p. 6). Maxwell gives again here a sign of his brilliant mind, ''degrading'' the demon to a valve, but also offering an inspiring perspective to oncosystems research. Which types of mechanisms exist in biological systems, and particularly in individual cells, to control these differential values in key parameters? Could changes of key physical parameters for metabolic processes of the cytoplasm and cell's organelles like temperature, volume, pH or electrochemical potentials be also implicated in cancer progression?