Results: The G to A variation of the PEMT gene G175A SNP was significantly higher in NAFLD group compared with controls. The frequencies of GG GA and AA genotypes were 58.8 39.2 and 2.0 in NAFLD and 78.0 22.0 and 0.0% in controls (P=0.038 . The A allele of the PEMT gene was significantly more frequent in NAFLD group (21.6%) than that (1.0%) in controls P=0.042 .There were significant differences in serum levels of cholesterol, triglyceride, HDL-C and LDL-C between GG and GA/AA genotypes P <0.05 .