Bid is a proapoptotic BH3-only member of the Bcl-2 family that functions to link the extrinsic apoptotic pathway and the mitochondrial amplification loop of the intrinsic pathway. Following death-receptor signaling, cytoplasmically resident Bid is cleaved by activated caspase-8 to generate a truncated form of Bid known as tBid [26] . tBid translocates to the mitochondria and triggers the release of cytochrome c and activation of the core mitochondrial apoptotic machinery [19, 27] . It is not known whether Bid plays a functional role in apoptosis induction by reovirus. Moreover, the relationship between apoptosis effector pathways and early events in viral replication are not understood.