Objective: Central nervous system metastases (CNSM) from breast cancer (BC) are relatively common and can present as the first site of disease progression. Lymph node status and tumor size are regarded as important prognostic indicators for disease-free and overall survival in BC. The aim of this study was to investigate prognostic/predictive pathological data in BC that could define a high-risk group to develop CNSM. Method: The authors evaluated 97 female patients with invasive breast carcinoma, not otherwise specified, previously submitted to setorectomy/mastectomy, in order to determine lymph node status, tumor size, histologic grade, estrogen receptor status (ER) and immunoexpression of HER2/neu. Of these cases, 10 patients developed CNSM. Results: The patients who developed CNSM were younger (median age 54.7±8.152 years/p=0.251) and more likely to have T2N2 disease than patients with no CNSM. The presence of encephalic disease was associated with ER (p= 0.031). Lymph node status (p = 0.84), tumor size (p = 0.339), histologic grade (p=0.933), and HER2/neu expression (p=0.31) were not significant risk factors. Conclusion: Although the literature data discriminate that HER2/neu overexpression in BC is related with CNSM, the authors suggests that these lesions can be related to ER too. Efforts to determine other risk factor for development of CNSM may be warranted.