Yoshino M 1 , Watanabe Y 1 , Yabe H 2 , Kato S 2 , Otomo T 3 , Sakai N 3 , Gasa S 4 , Hayasaka-Sukegawa K 5 1 Dept Pediatr & Child Health, Kurume Univ, Kurume, Japan 2 Dept Cell Tlanspl & Regen Med,Tokai Univ, Isehara, Japan 3 Dept Pediatr, Osak Univ, Osaka, Japan 4 Div Chem, Sapporo Med Univ, Sapporo, Japan 5 Dept Pediatr, Gifu Univ, Gifu, Japan