If we put all this information together, we clearly observe a pattern of downregulation of gene expression that is associated with an impairment of epidermis development and the maintainance of its structure ( Figure 8 and Table 1 ). This is, perhaps, an instantiation of one of the ''extended hallmarks of cancer'' (that of ''tissue dedifferentiation''). This process includes the loss of function of genes that are essential for the maitainance of tight junction and epithelial cell-cell communication. While loss of epithelial structure is related to these genes, we observe that those that increase expression are associated to other developmental processes, not necessarily concerted in this panel. Instead they show a pattern of increasing cell motility, chemotaxis and positive regulation of cell proliferation. We will first discuss the processes related to the loss of adhesion, which could be linked to an increased probability of metastatic potential of these cells.