The total treatment duration ranged from 30 days to 3 month. The variable prescriptions are presented in Table 1 . The different composition of formula Xiaoyaosan are presented in Table 2 . Nineteen (19) of the 26 trials used the hamilton depression scale (HAMD) as the outcome measure, other 4 kinds of scales including self-rating depression scale (SDS), self-rating anxiety scale (SAS), the scale for TCM syndrome and symptom differentiation (TCM-SSD), the hamilton anxiety scale (HAMA) were also be used. Side effect was evaluated by asberg side effect scale and treatment-emergent symptom side effect (TESS) scale or described in details. Eleven (11) trials used four classes to evaluate treatment effects including cure, significant effective, effective, ineffective, while ten (10) trials used three classes (except of cure) according to the scores reducing rate.