As shown in Table 1 , the values calculated by the QP program, such as PAS, logPo/w, logS, and PMDCK for the newly designed agonists are all within the reasonable ranges. Although the higher logPo/w value of a compound, the stronger its affinity to PPARs is, it is not a good idea to excessively enhance logPo/w because this would induce bad distribution of the compound on fat and body fluid [70] . It should be pointed out that, rather than the experiential values within the range between 26.5 and 0.50, most of the log S values for the new agonists are quite close to that of GW409544. Such a phenomenon might result from the core A part which was kept unchanged during the process of designing the newly compounds as mentioned above. If the core A part was modified as well, the log S value would be further improved accordingly. Also, as mentioned above, the values for the four ADME properties listed in Table 1 are all within the acceptable range for human beings, indicating that most of the 25 compounds, particularly the top 10 derivatives found in this study as highlighted in Table 1 , can be utilized as candidates for the purpose of developing new drugs.