SFPQ -(Polypyrimidine tract-binding protein-associated splicing factor). The most positively correlated gene with the loss of Normalized Shannon Entropy is SFPQ/PSF (Polypyrimidine tract-binding protein-associated splicing factor) (Spearman correlation of 0.7902), a multifaceted nuclear factor [496, 497] which is also a putative regulator of growth factor-stimulated gene expression [498] . This is extremely interesting as it has been recently shown that the AR/PSF complex interacts with human PSA gene and that PSF inhibits AR transcriptional activity [499] . The loss of expression of SFPQ and other proteins that together regulate androgen receptor-mediated gene transcription [500] (see also [501, 502] ) may indicate they have a role not only as a biomarker of the progression and well as transitions of the disease to androgen independence. In a study of human labor, Dong et al., also showed that SFPQ acts as a Progesterone Receptor corepressor, thus putatively contributing to the functional withdrawal of progesterone [503] . We will return to this particular gene later on the 'Discussion' section as new evidence of its role in nuclear organization has been documented.