Blood samples were prelevated to control SOD levels. The study respected all imposed ethical criteria. Results: Lacrimal glandular tissue exhibits a strong CuZn-SOD immunoreactivity, a moderate one for Mn-SOD and only a small EC-SOD reactivity, while the level of sanguin SOD is high, as a marker of oxidative aggression. Conclusion: Oxidative stress may be engagged in a deep alteration of lacrimal gland. Mobilisation of SOD, depending on their specific glandular location and tissular receptivity, should be regarded as a promising alternative for antioxidant therapy.