The expression of up-and down-regulated proteins was controlled in several different levels. From the comparisons between protein and mRNA abundance under the dysfunctional r 0 state, we found that most up-and down-regulated mt proteins had increased mRNA expression levels ( Figure 4 ). This indicated that up-regulated proteins were successfully recruited into r 0 mitochondria. It has been proposed that there is a compensatory mt protein import pathway independent from the dissipated membrane potential [47] . This pathway is known to facilitate the translocations of proteins involved in mt protein folding and mtDNA repair to the mitochondria [48] . It implies that ''emergency'' proteins are increasingly imported to dysfunctional r 0 mitochondria to repair pathophysiological mt conditions. The cross-talk properties of up-regulated functional modules support this idea.