Helminth defence (F) Bacterial defence (F) Skin Ulceration (P) Figure 5 Known anatomical locations of eosinophil granulocytes and suggested activities of released ECP at these sites. On the left side are eosinophil granulocytes locations at homeostasis shown. On the right side are areas speculated to be affected by increased numbers of eosinophils and elevated levels of released ECP, in disease (pathology, P) and in physiological defense (function, F). This is a speculation by the authors of the review.