To determine of importance of Caprin -1 overexpression new studies are necessary. Objective: Pseudohyperplastic squamous cell carcinoma of the penis (PSCC) is a low grade tumor with specific clinical and pathological features. This very uncommon tumor occurs in association with lichen sclerosus, the main location is foreskin, and the high degree of differentiation may difficult its discrimination with pseudoepitheliomatous hyperplasia. Method: A 66-year-old male presented a penis lesion involving glans and foreskin, clinically suspicious of malignancy. Size was 1,6×1,4 cm and a conservative resection was done. Pathological study was performed, and HPV detection with a commercially available kit: PCR amplification and reverse hybridization with probes to 35 HPV types. Results: The lesion showed a non-verrucous well differentiated squamous cell tumor. Upper layers lacked any atypia but infiltrative growth was evident in basal layers, with atypical cells and mitosis. Lichen slerosus changes were evident bordering the tumor. HPV was negative for all types studied. No further treatment was employed and after a 18 months follow-up no recurrence has been observed. Conclusion: PSCC should be taken in mind when handling penis tumors. A correct differentiation from benign lesions and a knowledge of its low grade to avoid overtreatment will benefit patients. Lichen sclerosus and not HPV seems to play a precancerous role.