Objective: Vascular endothelial growth factor (VEGF) is an important angiogenic glycoprotein secreted by the tumor cells and host cells which proved to be a powerful prognostic factor in various human cancers. The aim of our study was the evaluation of VEGF expression in colorectal carcinomas using immunohistochemistry, in order to identify the relationship between the presence of the protein in the tumor cells and a series of morphological parameters. Method: We analyzed 30 consecutive surgically removed colorectal carcinomas. Immunohistochemistry was done on formalin-fixed and paraffin embeded tissue sections, using the anti-human VEGF-A monoclonal antibody (clone VG1, Dako). The extent and intensity of staining were graded and used to calculate the immunoreactive score for each case. Statistical analysis was performed with SPSS (Statistical Package for the Social Sciences), using nonparametric tests. The level of statistical significance chosen was p <0.05. Results: VEGF was expressed in all tumors, with a heterogeneous distribution. The only parameters that correlated with high VEGF positivity were the extent of the tumor necrosis and the presence of lymph node metastases (p =0,001).