Consistent with these results, the CFUs isolated from spleen and liver of C57BL/6 and IFN-b floxb-luc/floxb-luc mice did not differ significantly, while IFN-b floxb-luc/floxb-luc x LysMcre and IFN-b 2/2 mice showed strongly reduced bacterial numbers in the organs 24 hours after infection (Fig. 6B) . Moreover, comparison of IFNb floxb-luc/floxb-luc mice with IFN-b floxb-luc/floxb-luc x CD11ccre, where IFN-b production is ablated in dendritic cells, showed no significant differences in bacterial loads in spleen and liver, as well as in serum levels of type I IFN ( Figure S2 ).