In total, we collected 87 eukaryotic IFITM homologues from H. Sapiens (14 genes) M. musculus (17 genes), G. gallus (6 genes), X. tropicalis (13 genes), D. rerio (7 genes), P. marinus (1 gene), C. intestinalis (1 gene), B.floridae (12 genes), S. manosoni (1 gene), S. purpuratus (9 genes), N. vectensis (4 genes) and M. brevicollis (1 gene). No IFITM genes could be detected in any of the remaining 24 analyzed proteomes, which covers all other major eukaryotic groups. The search of the nr database with HMMER did not get any hits outside metazoa except bacteria, choanoflagellates and the brown alga Ectocarpus siliculosus (2 genes). Nine genes were deemed as pseudogenes based on annotation and sequence analysis and removed from further analysis. In addition to the four previously identified human IFITM genes, ten novel human homologous genes were detected. These ten genes together with the four IFITM genes form a human gene family that we choose to call Dispanins based of their common 2TM structure. In UniProt we identified 65 annotated IFITM homologues from full bacteria proteome sets spread over seven different phyla (See table S1): Acidobacteria (2 genes), Actinobacteria (43 genes), Cyanobacteria (3 genes), TG1 (1 gene), Bacteroidetes (2 genes), Firmicutes (1 gene) and Proteobacteria (13 genes). Out of these, 46 bacterial sequences from 32 species were included for further analysis. No viral or Archaean genes were annotated as IFITM homologues in UniProt.