Objective: Although leimyomas of the uterus are common, lymphoid infiltration of leimyomas is a rare occurrence. We presented a case of a 45-year-old woman whose leiomyoma was diffusely infiltrated by lymphocytes. Lymphoid infiltration was analyzed with immunohistochemical methods and infiltration was found to be polyclonal type. Method: A 45-year-old woman with abnormal uterine bleeding was prediagnosed uterine leiomyoma and she was applied total abdominal hysterectomy and bilateral salphingo-oopherectomy. The analysis of the sample sent to pathology lab showed two leiomyomas. Hematoxylin eosin -stained slides were prepared after sampling. ımmunohistochemical stains were applied. Results: Microscopic examination of leiomyoma in greater diameter revealed a lesion with well-circumscribed borders composed of interlacing fascicles of bland monomorphic spindle cells diffusely infiltrated by lymphoid cells. The infiltrate not extended into the surrounding myometrium. Immunohistochemical analysis showed positive staining with CD 20, CD3, CD68. It was seen that inflammatory infiltration was polyclonal and involved T cells, B cells and histiocytes. Leiomyoma with lymphoid infiltration was diagnosed. The postoperative course was uneventful within a 6 month follow up period. Conclusion: Leiomyoma with lymphoid infiltration first described in 1989 by Ferry et all. From that date on, the literature involves few cases. Because it is rare and differential diagnose with malignant lymphoma is crucial, we presented the case and reviewed the literature. Objective: Vulvar intraepithelial neoplasia is divided into two groups: usual type and differentiated type. The differentiated vulvar intraepithelial neoplasia, which is frequently seen with invasive squamous cell carcinoma, can be confused with some benign lesions. The aim of this study is to analyse p16, p53, and Ki-67 expression characteristics of different histological types of vulvar intraepithelial neoplasia, invasive squamous cell carcinoma, and benign lesions of the vulva. Method: In this study, immunohistochemical analysis of 18 vulvectomy cases with p16, p53, and Ki-67 was performed. Results: Of 18 patients who underwent vulvectomy, nine had invasive squamous cell carcinoma and nine had vulvar intraepithelial neoplasia. Four additional vulvar intraepithelial neoplasia lesions were found accompanying the invasive squamous cell carcinomas. Nine benign lesions were found accompanying the invasive squamous cell carcinomas and vulvar intraepithelial neoplasia. Mean Ki-67 proliferation index was 32.3 % in the usual type of vulvar intraepithelial neoplasia cases and 26.4 % in the differentiated vulvar intraepithelial neoplasia cases. No p53 expression was present in benign lesions. Conclusion: Ki-67 PI does not recognize the usual type or differentiated type of vulvar intraepithelial neoplasia. p53 positivity can be of value in distinguishing differentiated type vulvar intraepithelial neoplasia from benign lesions.