Objective: WD is a rare, multi-systemic infection caused by a ubiquitous environmental bacteria -Tropheryma whippleithat affects the duodenum and small intestine but also the brain, endocardium, skin, lungs and joints. Method: We are presenting a 49 years old man with a 2 years history of diarrhea, malabsorption and weight lost (about 30 kg). Endoscopical examination revealed an unspecific, yet unusual pattern of lesions: small, yellow, multiple, slightly elevated patches involving duodenum and jejunum. Histological examination revealed numerous foamy macrophages in lamina propria with PAS (+), Ziehl-Neelsen (−) material in cytoplasm. Results: Treatment with trimethoprim/sulfamethoxazole was initiated with a spectacular response: after 2 days of therapy the patient had normal stool and in 6 months he already gained back 20 kg. After 1 year of treatment the biopsy confirmed a partial remission with fewer macrophages persisting in lamina propria of duodenum. After 16 months of treatment (March 2012), very few macrophages with PAS (+) material are still identified on duodenal biopsy. Conclusion: WD is a potentially fatal disease with unspecific clinical and endoscopical signs that can be diagnosed on duodenal biopsies. Histological follow-up is a useful tool of managing the treatment and histopathological confirmation of the absence of foamy macrophages is mandatory in discontinuing therapy. Molecular Imaging Reveals a Progressive Pulmonary Inflammation in Lower Airways in Ferrets Infected with 2009 H1N1 Pandemic Influenza Virus Molecular imaging has gained attention as a possible approach for the study of the progression of inflammation and disease dynamics. Herein we used [(18)F]-2-deoxy-2-fluoro-D-glucose ([(18)F]-FDG) as a radiotracer for PET imaging coupled with CT (FDG-PET/CT) to gain insight into the spatiotemporal progression of the inflammatory response of ferrets infected with a clinical isolate of a pandemic influenza virus, H1N1 (H1N1pdm). The thoracic regions of mock- and H1N1pdm-infected ferrets were imaged prior to infection and at 1, 2, 3 and 6 days post-infection (DPI). On 1 DPI, FDG-PET/CT imaging revealed areas of consolidation in the right caudal lobe which corresponded with elevated [(18)F]-FDG uptake (maximum standardized uptake values (SUVMax), 4.7–7.0). By days 2 and 3, consolidation (CT) and inflammation ([(18)F]-FDG) appeared in the left caudal lobe. By 6 DPI, CT images showed extensive areas of patchy ground-glass opacities (GGO) and consolidations with the largest lesions having high SUVMax (6.0–7.6). Viral shedding and replication were detected in most nasal, throat and rectal swabs and nasal turbinates and lungs on 1, 2 and 3 DPI, but not on day 7, respectively. In conclusion, molecular imaging of infected ferrets revealed a progressive consolidation on CT with corresponding [(18)F]-FDG uptake. Strong positive correlations were measured between SUVMax and bronchiolitis-related pathologic scoring (Spearman’s ρ = 0.75). Importantly, the extensive areas of patchy GGO and consolidation seen on CT in the ferret model at 6 DPI are similar to that reported for human H1N1pdm infections. In summary, these first molecular imaging studies of lower respiratory infection with H1N1pdm show that FDG-PET can give insight into the spatiotemporal progression of the inflammation in real-time. In March of 2009, an outbreak of a novel variant of H1N1 influenza A virus was reported in cases of influenza illness in Mexico [1] . By June 11, the World Health Organization raised the pandemic alert level to its highest level, declaring the first influenza pandemic in over 40 years [1] . Unlike seasonal influenza viruses, this novel H1N1 pandemic strain (H1N1pdm) tended to affect younger healthier populations and had an increased risk of morbidity and mortality [2] [3] [4] with 12-30% of the population developing clinical influenza, 4% of those requiring hospital admission, and 1 in 5 requiring critical care [5] . In general, however, infection of the H1N1pdm was relatively mild in most persons, although a fatal viral pneumonia with acute respiratory distress syndrome occurred in approximately 18,000 cases.