SCD is heterogeneous in its clinical presentation with patients being continuously admitted for the management of disease-related complications at one end of the spectrum and patients rarely requiring medical care at the other [6] . Irrespective of the frequency of acute clinical complications, most patients develop accumulating organ damage throughout their lives as a result of chronic hemolytic anemia and ongoing vaso-occlusion [1] . With respect to QoL, previous studies have reported that sickle cell patients have lower QoL scores when compared with race-and age-matched controls, which were related to pain [8] [9] [10] . However, its relation to the presence of chronic organ damage has not been described before. In the present study, organ damage appeared not to be related to any of the QoL scores. If patients were grouped according the pathophysiology of their different forms of organ damage or a history of sickle cell-related complication as recently proposed by Kato et al. [11] , also no relation with QoL scores was demonstrated. Surprisingly, PHT, which has been related to early mortality in SCD, was not related to QoL in our patients. This might be explained by the fact that our study population consists of patients with mild PHT (regurgitation jet flow velocity < 2.9 m/sec), which is generally not related to severe complaints or significantly reduced exercise tolerance.