Among the symptomatic treatments, need for hemodynamic management is the most apparent, but modalities continue to be discussed and the scientific literature abounds with studies in this area. Efficient restoration of circulating blood volume is the primary goal of resuscitation in septic patients [42] . Albumin was the first product to be broadly used for intravenous fluid loading, but a meta-analysis comparing albumin with other fluid loading agents [43] identified an increased risk for death among patients who received albumin for supportive treatment during shock. However, subgroup analysis (septic patients with hypoalbuminemia) [44] revealed a trend toward greater efficiency of fluid loading with albumin. The cost-benefit balance is another factor that has restricted use of albumin, but in their recent report Guidet and colleagues [45] indicated that albumin infusion was potentially cost-effective in patients with sepsis. Thus, use of albumin should be considered with caution; it currently lacks the support needed for it to be recommended for use in patients with septic shock.