The vasodilatory actions of Ang-(1-7) have been reported in many studies in several vascular beds and preparations, including mouse [16, 23] and rat [15] aortic rings, canine [87] and porcine [88] coronary arteries, canine middle cerebral artery [89] , porcine piglet pial arterioles [90] , feline mesenteric vascular bed [91] , rabbit renal afferent arterioles [92] , and mesenteric microvessels of normotensive [93] and hypertensive [94] rats. Vascular Ang-(1-7) actions are still controversial in human. For example, it has been shown that Ang-(1-7) causes vasodilation in forearm circulation of normotensive subjects and patients with essential hypertension [95] while other studies were unable to report any significant effect of Ang-(1-7) in the same vascular territory in ACEi-treated patients [43] .