The clinical manifestations of avian influenza in humans has ranged from mild conjunctivitis to severe pneumonia with multi-organ system failure ( [53] . However, with HPAI in Hong Kong in 1997 and in Southeast Asia currently, pneumonia progressing to multiorgan failure, acute respiratory distress syndrome (ARDS), and death are the predominant findings [17, 55, [65] [66] [67] [68] . Rye syndrome, pulmonary hemorrhage, and predominant nausea, vomiting, and diarrhea complicate these cases [68] . Laboratory findings include both thrombocytopenia and lymphopenia [65, 66] . Chest radiographic findings include interstitial infiltrates, lobar consolidation, and air bronchograms. The clinical course of patients with HPAI H5N1 is rapid, with 68% percent of patients developing ARDS and multiorgan failure within 6 days of disease onset [69] . The case fatality rate ranges form 67% to 80%, depending on the case series [17, 55, 65, 66] . Once the patients reached the critical care unit, however, the mortality rate was 90% [69] . The average time of death from disease onset was nine to ten days.