An overall comparison of the PLs regulated at the 36 and 60 hr time points indicated that in all lipid classes that were significantly regulated (Anova p,0.05) during DENV infection, selected molecular species were regulated only at the 36 hr time point while others were regulated at both time points. Representative examples for each lipid class are shown ( Figure 3C -H). These observations may represent lipidome differences in cells sustaining early but active DENV replication (36 hr) compared to those experiencing advanced cellular stress (60 hr). It is also interesting to note that any up regulation observed in UV-DENV exposed cells (at either time point) was only in the range of 1-1.5 fold compared to the mock control, while DENV infected cells showed much higher levels of expression.