The discovery of a polysemous codon in a Candida species contradicts the established notion of aminoacyl-level of ODCase activity arising from a slight incorporation of leucine at the CUG codon in the 45th position, we ation with high fidelity. We have shown that a single tRNA is acceptable to two different amino acids, and adjusted the ratio of 5FOA and uracil as shown in Materials and methods. This growth rate reduction clearly suggests that it can therefore transfer two different amino acids corresponding to a particular codon. The expression that the slow growth observed in the SD medium was due to low expression of active ODCase. Thus it is concluded experiment using the ODCase-encoding URA3 gene containing codon CUG at the site essential for its activity that the CUG codon is partially translated as leucine in C.maltosa cells.