In another study, patients with chronic hepatitis C performing silymarin (650 mg/day) for 6 months improved serum HCV-RNA titer, serum aminotransferases (ALT, AST), hepatic fibrosis, and patient's quality of life. After the treatment, nine patients were found with negative HCV-RNA and statistically significant improvement in results of liver fibrosis markers was found only in fibrosis group.