HBoV was found in 1.5-11.3% of respiratory samples investigated worldwide [2] [3] [4] [5] . HBoV may be a causative agent of respiratory tract infections. However, some investigators argue that the association between HBoV and respiratory tract diseases remains unproven because of the high rate of codetection of HBoV with other respiratory pathogens [5] . Its clinical epidemiology and role in respiratory infection have not yet been fully elucidated.