Objective: The matters of materials development of scull bones defect plastic are obviously necessary this time. The experience in use of nanocostructive titans, composites, bone morphogenetic proteins was accumulated. Method: Implant, made of nanoconstructed titan Grey, covered by 1 layer (gelatin, dextran), 2 layers (1-gelatin, dextran, 2-hydroxyapatite, collagen, dextran) and by 2 layers with use of bone morphogenetic proteins BMP-2. The experiment was conducted on 240 rat-males. In order to study the regeneration processes it were used light, fluorescence, probe and scanning microscopy with the trace element analysis. Results: The most active changes were registered in the experimental group with use of composite from titan Grey with 2 layers of covering and BMP-2. The covering compound increase the rate of regeneration processes due to creation calcium and phosphorus ion depot and perform support function for again-formed tissue. Increase in the concentration of calcium, phosphorus, sodium, magnesium in trabeculae of bones in comparison with matrix bone at term of 12 weeks testify about active regenerative processes; the mature smooth surface with structured relief of bone trabeculae and diploic veins were detected.