Method: Three cases of NCD were enrolled from the archive of dermatopathology department of Razi hospital during 2009-2011. Results: In this report, three cases, all presented with multiple plaques and nodules in the nose and the face, are depicted. Histologically, these nodular masses were homogeneous, with eosinophilic clefted materials expanding the papillary dermis and extending into the deep dermis. Histochemical review showed the reactivity of the colloid materials via the PAS, crystal violet and methyl violet staining. All the three cases were finally diagnosed as nodular colloid degeneration. Conclusion: NCD is a rare disease but it should be considered in any cases with a history of long exposure to the light. We suggest the long term exposure to the sun as an etiologic factor thus, sun protection would be the most preventive and available treatment.