A meta-analysis of four trials [7, 8, 16, 27] with five comparison using TESS scale scores showed less side effect (WMD: −2.51 [−3.18, −1.84]; P < 0.00001) using xiaoyaosan plus antidepressants compare to antidepressants using alone with significant heterogeneity (I 2 = 87.2%). There is another trial [18] showed modified xiaoyao decoction had less side effect compared to amitriptyline (WMD: 