Pegylated interferon (PEG-IFN) plus Ribavirin therapy is the current treatment for the patient with chronic hepatitis C. The main goal of therapy is to achieve a sustained virological response (SVR is defined as undetectable HCV-RNA in peripheral blood determined with the most sensitive polymerase chain reaction technique 24 weeks after the end of treatment). This goal is practically equivalent with eradication of HCV infection and cure of the underlying HCV-induced liver disease. This therapy is effective only in half of patients, because of important side-effects, resistance, and high cost related to therapy. Silymarin inhibits both HCV RNA (in a dose-dependent manner) and HCV core expression thanks to its direct effect against HCV 3a core or activation of JAK/STAT pathways, resulting in inhibition of HCV core gene, by phosphorylation of Stat1 on tyrosine and serine [60] .