All virus subtypes tested replicated in ferrets following ocular inoculation, as measured by detectable virus in NW samples as early as day 1 p.i. (Table 2 and Figure 1 ). The duration of virus shedding from NW samples and transient fever and weight loss generally mirrored that seen following intranasal (i.n.) inoculation for each virus [26] [27] [28] [29] . However, in comparison to i.n. inoculation, the incidence of nasal discharge was reduced following i.o. inoculation with all influenza viruses tested, and