However, later in the course of infection, by day 6, viral OB titers in Ifit2 2/2 mice were not significantly changed, whereas in wt mice average titers of infectious VSV as well as viral RNA levels had decreased by ,10-fold ( Figure 3C and D, both p,0.05). These results suggest that VSV initially enters and replicates with similar efficiency in both wt and Ifit2 2/2 OB before spreading into the rest of the brain.