Despite well-characterized tumor-induced immunomodulation, immunotherapies such as monoclonal antibodies are emerging as key diagnostic and therapeutic modalities and are now standard of care for the treatment of various cancers. Antibodies for the treatment of melanoma aimed at enhancing key pathways of T cell activation (Cytotoxic T Lymphocyte-Associated Antigen 4, e.g. Ipilimumab), targeting tumor vasculature (e.g. Bevacizumab), or tumor-associated antigens (e.g. High Molecular Weight-Melanoma Associated Antigen, HMW-MAA) have demonstrated promise in clinical studies [13, 22, 23, 24] . Antibodies therefore represent an attractive approach for the treatment of melanoma.