Objective: Non-infectious erythematous, papular and squamous lesions of the skin are basic lesions that pathologists differentiate in routine laboratory examinations. Our aim has been to analyse these lesions by pathologic and clinical findings in our institute with determining clinicopathologic correlation. Method: In our study 420 cases prediagnosed as erythematous, papular and squamous lesion by dermatologists and evaluated in pathology laboratory between 2004 and 2010 have been reviewed. Results: The lesions comprised %14.3 of the total load of surgical pathology and 9.1 % of total number of skin biopsies. The highest percentage was in the 41-50 year age group (39.1 %) with a female predominance of 51.2 %. The limbs were most frequently involved (36.9 %). Psoriatic lesions were the commonest (50.7 %), classic generalized plaque variant psoriasis (89 %) being the most frequent. Correlation with the histopathologic diagnosis was positive in 75.3 % cases and negative in 24.7 % cases.