Subsequently, each of the 25 derivative compounds was docked into the two receptors PPARa (1k71) and PPARc (1k74), respectively. Listed in Table 1 are the 25 derivative compounds ranked roughly according to their docking scores to the receptors PPARa and PPARc, respectively. The top ten compounds highlighted with boldface type in Table 1 are those derivatives that are stronger than the original GW409544 in binding affinity with the two receptors. Of the top ten derivatives, the Comp#1, i.e., ''Core A-Core B1-Core C1'', has the strongest binding affinity with both PPARa (1k71) and PPARc (1k74), and hence it was singled out for further investigation.