The results can be observed in Figure 2 . On the x-axis, the lymph node metastases have the largest values of M-Normal indicating a divergence from the normal profile. In addition, the M-metastases values of normal samples tend to be higher than most of the metastasis samples (with the exception of only one). Figure 2 shows a gradual progression of the samples positions on this plane from a well-differentiated tissue type specific profile, first to a more heterogeneous primary tumor cluster, and finally to an even less differentiated metastatic profile.