Proteomics is a technique that enables one to find proteins changed by the cells response to internal states, external stimulations or developmental cortex. The technique of the two-dimensional elec-trophoresis (2DE) allows global profiling of the proteomic changes in different disease states or conditions. Two studies into chemically induced epilepsy (pilocarpine) have investigated the proteomic profile following epileptogenesis in the whole hippocampi alone or in conjunction with the forebrain in rats. These suggested upregulation of pathogenic, neuroprotective and neurogenic responses with validation performed using Western blotting and immunohistochemistry (36, 59) .