In this descriptive study, we will demonstrate therapeutic processes of clinical cases of maladaptive patients with moderate mental retardation. Although behavioral interventions are one of the most effective treatments to such populations, the relationship often encounters difficulties and the therapy becomes unprogressive. It is partly because of their limitation of ability to use language which enables them to understand and express their thoughts, feelings and understandings. The aim of this descriptive study is to show some of the examples of inventive approaches which thought to be helpful to the progression of the therapies for the patients with a mental handicap. Method (process of treatment): The patients were male 20 s and female 30 s, both were unmarried and lived with their families. Three years of outpatient therapy, conducted once every two to three weeks, took place at the psychiatric hospital. Medication and behavioral interventions, including management of use of social welfare services and psycho-education, were given. In addition, the following approaches were developed in the course of treatment: (1) Psychiatrist and psychologist worked as a team to deal with the patients, and discussed about emotional burden that had been experienced.