Over the past two years, we have taken on this challenge by developing a macaque influenza infection model that features genomic and proteomic analyses as a key component of the experimental design. Carole Baskin has taken a leading role in this effort and was the first to report on the use of genomic technologies to characterize experimental influenza virus infection using a pig-tailed macaque model [25] . This study was performed using a mildly pathogenic strain of virus (A/Texas/36/91) with the goal of constructing a blueprint of an uncomplicated influenza infection. Gene expression profiling performed on lung tissue and tracheobronchial lymph nodes revealed that numerous genes associated with the interferon response were differentially expressed, particularly at day 4 after inoculation. We also observed an increase in the expression of genes encoding various mediators of chemotaxis, adhesion, and the transmigration of immune cells, suggesting the trafficking of these cells into the lungs and tracheobronchial lymph nodes, which was confirmed by histopathology. In addition, this study revealed gene expression changes relevant to the processing of antigens on MHC class I complexes, particularly in lung tissue, and many genes encoding proteins relevant to T-cell function were induced at one or more time points.