Slowik et al. (26) reported that the II genotype of ACE gene contributes to vascular dilatation at the site of aneurysm by 1) increased bradykinin activity, 2) another polymorphism responsible for vascular dilatation that is in linkage disequilibrium with ACE I/D polymorphism, 3) degeneration of endothelial cells, or 4) lack of vascular remodeling.