The ELM motif detection pipeline scans protein sequences for matches to the regular expressions of annotated ELM classes ( Figure 2 ). The query output combines these putative instances with information from the database (annotated ELM instances) as well as predictions from different algorithms/filters. The ELM resource employs a structural filter (18) to highlight and mask secondary structure elements, as well as SMART (19) to detect protein domains. Furthermore, an additional disorder prediction algorithm (IUPred) (20) has been included to predict ordered/disordered regions within the protein.