To examine whether up-regulated and down-regulated proteins participate in different biological processes, we examined the enriched function of proteins according to abundance ratios. We discovered that significant biases exist between the two groups when they were classified by GO biological process terms (Table S2 ). Functions of upregulated proteins were involved in mRNA metabolism and cytosolic ribosome-mediated translation, whereas down-regulated proteins were involved in mt ribosome-mediated translation, oxidative phosphorylation, and the TCA cycle (p-value ,1610 23 ).