In this study, we have focused on the importance of lipid biosynthesis on dengue virus (DENV) replication. DENV is one of the most aggressive re-emerging pathogens worldwide [13] . Over two and a half billion people in more than 100 endemic countries are at risk for contracting dengue fever. Currently 50-100 million cases of dengue fever are estimated annually [14] . Since DENV replicates within the mosquito vector as well as the human host, the spread of the virus can be greatly reduced by controlling the vector. Much effort has been placed in understanding the dynamics of virus transmission and replication in the mosquito vector, including identification of host proteins in the midgut and salivary glands that are regulated by DENV infection [15] [16] [17] . Less is known about the global impact of DENV on host metabolic pathways.