We undertook a comparative analysis of all HRV A2 complete coding regions (n = 6; HRV-QPM, -X1, H2, -C024, -C025 and C026) against all HRV A (n = 34), HRV B (n = 13), most HEV sequences (n = 71, including species A-D) and two non-human enteroviruses (simian, SEV and porcine, PEV).