All statistics were performed using R version 2.13.0 and GraphPad Prism 5. For each image, mean SUVMax and standard deviations were obtained. For each ferret, SUVMax values were correlated with histopathologic scoring using Spearman's Rho (r). The Dynamics, Causes and Possible Prevention of Hepatitis E Outbreaks Rapidly spreading infectious diseases are a serious risk to public health. The dynamics and the factors causing outbreaks of these diseases can be better understood using mathematical models, which are fit to data. Here we investigate the dynamics of a Hepatitis E outbreak in the Kitgum region of northern Uganda during 2007 to 2009. First, we use the data to determine that [Image: see text] is approximately 2.25 for the outbreak. Secondly, we use a model to estimate that the critical level of latrine and bore hole coverages needed to eradicate the epidemic is at least [Image: see text] and [Image: see text] respectively. Lastly, we further investigate the relationship between the co-infection factor for malaria and Hepatitis E on the value of [Image: see text] for Hepatitis E. Taken together, these results provide us with a better understanding of the dynamics and possible causes of Hepatitis E outbreaks. Outbreaks of diseases such as avian influenza, SARS and West Nile Virus have alerted us to the potentially grave public health threat from emerging and re-emerging pathogens [1] [2] [3] . Many important infectious diseases persist on a knife-edge: rapid rates of transmission coupled with brief infectious periods. Such violent epidemic behavior has been observed in plague [4] , cholera [5] , pertussis [6] and more recently Hepatitis E. The recent outbreak of Hepatitis E in northern Uganda, has left many dead and a number of infectives that continue to spread the infection [7] . Hepatitis E is caused by infection with the Hepatitis E virus (HEV) which has a fecal-oral transmission route. It is a self-limiting disease but occasionally develops into an acute severe liver disease. As emerging and re-emerging infectious diseases increase in outbreak frequency, there is a compelling interest in understanding their dynamics [8] [9] [10] .