In the initial management of patients with sepsis, improving physiological parameters such as blood pressure and tissue oxygen delivery is a clear goal, as has been emphasized by experts since the late 1990s [63] . Previous studies underscored that applying an early goal-directed therapy (EGDT) approach could improve survival. The landmark study conducted by Rivers and coworkers [48] emphasized this concept in the field of sepsis. Its publication in 2001 prompted a debate in basic medical practice centered on the question, is it possible to improve outcomes in septic patients by increasing tissue oxygenation parameters during the first 6 hours of management?