There was a significant effect of genetic feedback compared to phenotypic feedback on adherence at 7-day follow-up (75% vs 69%, p=0.040), and a marginally non-significant effect at 28-day follow-up (69% vs 64%, p=0.098). There were similar effects on abstinence at six-month follow-up (14% vs 8%, p= 0.018). Amongst those not abstinent at 6-month follow-up, there was no difference in motivation to make another quit attempt between trial arms (p=0.23). This is the first test of the behavioural impact of pharmacogenetic feedback. Genetic feedback had a measurable impact on shortterm medication adherence and abstinence at 6-month follow-up compared to phenotypic feedback, and appears to offer modest improvements to medication adherence to medication, and NRT effectiveness. This suggests potential for an important population impact. Prostate cancer is the most common form of cancer in men (other than skin cancer). The American Cancer Society estimates that 1 in 5 men will get prostate cancer sometime during his lifetime, and that 1 man in 35 will die of this disease. The society also estimates that more than 2 million men in the United States who have prostate cancer at some point are still alive today. Much of the current treatment for cancer (including surgery and hormone therapy) involves temporary or permanent impotence or urinary incontinence which would be distressing for all men but particularly for those who are invested in their sexual performance or being in control as signs of their masculinity. Men may therefore forego treatment or delay it, leading to increasing risk of complications from prostate cancer. Presenters in this symposium will look at the impact of male sex role norms (including emotional restriction, emphasis on sexual ability, and being independent) on diagnosis for prostate cancer as well as recovery from treatment. They will examine the kinds of responses men have to being diagnosed and treated for prostate cancer, the type of support they seek and find useful after treatment, and the role partners can play in helping men cope.