The entire household will be withdrawn from the study if there is failure to obtain proper informed consent from any one or more individual household contacts for whatever reason. Informed consent will be sought from each individual household contact, or proxy consent from the parents of any individual under the age of 18. Assent will also be obtained for children age between 7 through 17. Households will be withdrawn from the trial if no home visit can be scheduled within 36 hours. Withdrawn households will be replaced to maintain the specified sample size. If one or more household contacts are not present during one of the home visits, we will attempt to reschedule a supplementary home visit to collect clinical specimens, and in the case where the initial home visit was missed we will request signed informed consent and apply interventions as necessary during the supplementary home visit.