Humanized mAb against Dengue Virus www.plosntds.org DENV located in E-DI [55, 56] Currently, we are in the process of identifying the neutralizing epitopes of DB2-3 and DB23-3. mAbs that broadly cross-react with other flaviviruses are in E-DII near the fusion loop, which is immunodominant antigenic [20, 34, 42] . Binding an antibody to DENV can change the rearrangement of the E protein, which may neutralize or enhance viral infection [16, 57] . The high or no neutralizing activity of our mAbs can be used help identify neutralizing or immunopathogenic epitopes in the E protein. Studies that explore the mAbs mediated neutralization mechanism and mAbs dependent enhancement are currently underway.