Hospital patient sera were collected from Shands Hospital at the University of Florida (UF) (SH-UF) from January 2004 to December 2006. We collected sera from 21 patients with candidemia where the etiological agent was C. albicans. The median time from the date of positive culture to serum collection was two days. The study population was classified by age, gender, underlying disease, portal of entry, antifungal received, and outcome of stay (Table S1) . A subset of the candidemia patients was followed through acute infection (days 0-14) to early convalescent (week 4) and mid convalescent (week 12) infection. We also used sera from 12 hospital patients and 50 healthy individuals who had no evidence of candidiasis as our negative control groups.