Method: Retrospective review of clinical data of PCNHL patients diagnosed in Hematology Department, Frahet Hached Hospital, Sousse (1993 . Results: Fourty three patients with PCNHL, median age: 48 years (11-84), sex-ratio was 2.3. The site of cutaneous involvement was upper lumb in 4 cases, lower lumb in 7 cases and disseminated in 23 cases. PCNHL was small T cell lymphoma in 13 cases, large B cell lymphoma in 16 cases, anaplastic, CD4+ CD56+ hematodermic neoplasm, and follicular type in 1 case respectively. According to TNM classification 21 cases were T3bNxMx, 12 cases were T1N0M0. After first line therapy, 26 patients in CR, PR was obtained in 1 case and failure in 6 cases, 10 patients relapsed within 1 to 72 months (median 6 months), all of them were disseminated cases. Conclusion: Our study indicate that the extend of cutaneous involvement at the time of diagnosis is a significant prognostic factor in PCNHL. Objective: Follicular lymphomas (FLs) account for one third of non Hodgkin lymphomas (NHLs) in adults. The disease is characterized by a response to initial treatment, followed by relapses, sometimes associated with histologic transformation into high grade NHL. Analyze epidemiological characteristics of patients with FL. Method: Retrospective study of 22 of adult FLs diagnosed in Hematology Department (2000) (2001) (2002) (2003) (2004) (2005) (2006) (2007) (2008) (2009) (2010) (2011) . Results: Median age was 59 years (29-77), sex-ratio: 1.7 The most frequent clinical symptom at diagnosis was lymphadenopathy in 13 cases. Involvement of the spleen in 3 cases. B symptoms were present in 10 cases. Performance status was more than 1 in 4 cases. According to the international prognostic index (FLIPI), 7 patients have low index, 5 have intermediate index, and 10 have high index. Grade 2 FL was seen in the majority of cases. Treatment modalities varied over time and according to the disponibility of drugs especially to anti CD20 monoclonal antibody. CR was obtained in 13 cases, PR in 6 cases; 3patients relapsed within 8-48 months. Histologic transformation was seen in 3 cases, we have noted 10 deaths related to the disease in 7 cases. Conclusion: Treatment results in FL might not only be improved by more effective induction regimens but also by maintenance treatment. Objective: CD99 and FLI-1 are widely used for their diagnostic utility in Ewing sarcoma/peripheral neuroectodermal tumor (ES/PNET). CD99 expression has been documented in a variety of tumors, including lymphoid malignancies of T cell origin. Also FLI-1 expression is common in different tumor types. However, few studies have investigated the CD99 and FLI-1 immunoreactivity in diffuse large B-cell lymphoma (DLBCL). We aimed to determine the frequencies of CD99 and FLI-1 immunohistochemical expressions in DLBCL which may lead to a misdiagnosis. Method: CD99 and FLI-1 expressions are retrospectively investigated by immunoperoxidase staining in prechemoterapy primary tumors of 42 DLBCL cases.