The studies outlined in this review provide just a glimpse of how we're using genomic and proteomic technologies to unravel the complexities of virus-host interactions. In addition to work with HCV and influenza, we're using genomic approaches to study a variety of other viruses. Tracey Baas heads collaborative research on SARS coraonavirus [36] and herpes simplex virus [37] . When not working on pandemic influenza, John Kash also leads efforts focused on Ebola virus [38] and vaccinia virus [39] , and Matthew Thomas and Michael Agy have explored gene expression changes associated with simian immunodeficiency virus infection [40] . We've also worked with Michael Gale on West Nile virus [41] , and in our work on P58 IPK (a cellular PKR inhibitor), we've even explored gene expression patterns associated with pancreatic β-cell depletion in diabetic mice [42] . Jamie Fornek is continuing the work on P58 IPK , including using P58 IPK knockout mice and genomics to examine the role of this PKR inhibitor during influenza virus infection. Gregory Zornetzer is developing a targeted proteomics approach to identifying protein-protein interactions associated with key viral proteins.