The phage display biopanning procedures were performed according to previous reports [28, 32] . Briefly, an ELISA plate was coated with mAbs at 100 mg/ml. Samples of 100 ml diluted mAb were then added to wells and incubated at 4uC for 6 h. After washing and blocking, the phage-displayed peptide library (New England BioLabs, Inc.) was diluted to 4610 10 pfu of phage and incubated for 50 mins at RT. After washing, bound phage was eluted with 100 ml 0.2 M glycine/HCl (pH 2.2) and neutralized with 15 ml 1 M Tris/HCl (pH 9.1). The eluted phage was amplified in ER2738 for subsequent rounds of selection. The phage was titrated onto LB medium plates containing IPTG and X-Gal. The biopanning protocol for the second and third rounds was identical to the first round except for the addition of 2610 11 pfu of amplified phage for biopanning.