Objective: Hepatocellular carcinoma (HCC) is frequently associated with liver cirrhosis or chronic hepatitis of various etiology, less often with other chronic hepatopathies, including hepatic porphyria. We present a case report of HCC diagnosed in patient with clinically unrecognized porphyria cutanea tarda (PCT). Method: A 70-year old male was admitted to hospital complaining of a pressure below low costal margin, anamnesis of a trauma 1 year ago and clinical suspicion of a posttraumatic intrahepatic haematoma. By a surgery, a partialy necrotic and hemorrhagic tumor mass 10 cm in diameter was removed. Results: The mass corresponded histologicaly to moderately differentiated clear cell HCC, resembling renal clear-cell carcinoma. The surrounding parenchyme showed steatohepatitis with fibrosis and distinct intracellular porphyrin crystals. Conclusion: Development of HCC is a well documented complication of PCT, a disorder of porphyrin biosynthesis. PCT can be inherited (autosomal dominant trait), the acquired form (sporadic PCT) is more common. Known etiological factors of PCT include toxins, alcohol abuse, estrogens or chronic viral hepatitis, or association with other hepatic diseases like iron overload (including hereditary haemochromatosis) or chronic hepatitis C, increasing the risk of malignancy. However, in the presented case none of these associations was recognized and its etiology remains obscure. Objective: Signet ring cell carcinoma is an extremely rare type of gallbladder carcinoma composed overwhelmingly (90 %) of signet ring cells. Only a few cases of this histologic type have been published and detailed knowledge of this disease is not available. Method: We report a case of signet-ring cell carcinoma of the gallbladder in a 70-year-old woman who was admitted with epigastric pain. Under the preoperative diagnosis of cholangiocarcinoma, which was based on findings of CT scan and ultrasonography. Cholecystectomy was performed. Results: Microscopic examination revealed a signet ring cells tumor that arose from the sub epithelial layer of mucosa and involved all the layers of gallbladder. Nuclear atypia and mitoses were present. Periodic acid schiff (PAS) stain highlighted the intracellular mucin in the tumor cells. Lympho-vascular emboli were detected in the subserosal layer. The cystic duct surgical margins were invaded. Conclusion: Gallbladder adenocarcinomas are seen frequently, but signet-ring cell carcinoma is a rare entity. Owing to the location of the gallbladder, dissemination of the tumour to the adjacent tissues is usually presented at the time of the diagnosis. It is necessary to exclude a gastric or colonic signet ring cell carcinoma secondarily involving the gallbladder. Objective: Gastrointestinal stromal tumors (GISTs) are mesenchyme neoplasms of the gastrointestinal tract which express CD117. GISTs can occur in the entire length of gastrointestinal tract, but very seldom can also arise in omentum, mesentery and retroperitoneal space, kidney, urinary bladder etc. There they are located adjacent to stomach or intestine, but not originated from the latter. These tumors are designated as "extra-gastrointestinal stromal tumors" (EGISTs). There are only 14 description of the Primary EGISTs reported in the literature. Method: We report a case of a pancreatic EGIST in a 38year-old female patient. Results: CT scan showed a mass in the head of pancreas. Grossly encapsulated tumor, 9 cm in diameter, was found in the head of the pancreas (Figure 1) . Histologically, tumor demonstrated spindle-cell pattern consisted of distinct fascicles and bands. The number of mitoses was 1-2/50 high power fields in "hot-spot" areas. IHC revealed strong positivity for CD117, CD 34 in neoplastic cells and negative for SMA, desmin, S-100. Ki67 labeling index was 3 %. Conclusion: We presented a rare case of pancreatic GIST. The tumor has very good prognosis. Hepatoblastoma is classified as epithelial (56 %) or mixed epithelial/mesenchymal (44 %). Epithelial hepatoblastoma is further divided to pure fetal (31 %), embryonal (19 %), macrotrabecular (3 %) and small cell undifferentiated (3 %). Aim: To increase the awareness regarding possibility of hepatoblastoma in adult age. Method: We review four cases of hepatoblastoma epithelial type diagnosed in Pathology Department of Fundeni Clinical Institute between 2009 and 2012. Immunohistochemistry was done in all cases: CEA, Vimentin, CK 8/18, CK 19, CK 20, Ki 67, TTF1, CD 10, CD 34, CD 56, MUC 5A, alpha-fetoprotein. Results: Two of the patients were males and two females with age ranging between 17 and 27 years. The tumors varying in size from 8 to 12 cm. On microscopic examination the tumor was composed mainly of epithelial elements. The pathological diagnosis was epithelial hepatoblastoma epithelial type. Conclusion: Hepatoblastoma is a rare tumor in adult age and epithelial type is the rarest from all type of hepatoblastoma in adult age. The pathological diagnostic is quite difficult even using immunohistochemistry because none of the markers are not specific for hepatoblastoma.