PS-14-026 Hepatocellular carcinoma microvessels density depends on tumor differentiation: Radiologic-pathologic correlations A. Shchegolev * , E. Dubova, U. Tumanova * V.I. Kulakov Scientific Center, Dept. of Pathology, Moscow, Russia Objective: Prognosis and recurrence level in hepatocellular carcinoma (HCC) depends on microvessels density. Method: We performed CT and pathological correlations in 22 cases of HC (5 cases of highly (h-HCC), 11 cases of moderate (m-HCC) and 4 cases of low differentiated HCC (l-HCC)). Results: Vessels number in w-HCC in compare to m-HCC was higher by 26.1 % (p<0.05). Total vessel area was higher in m-HCC and l-HCC than in w-HCC by 11.7 % and 20.4 % accordingly. We observed positive correlation between CT density of h-HCC and number and total vessel area. Correlation between h-HCC CT density and mean vessel area was negative. We also revealed modest negative correlation between m-HCC density and the number vessels in all phases of CT. Negative correlation between total and mean vessel area and m-HCC density was revealed in native and arterial CT phases in compare with venous and delayed phases where positive correlation was revealed. In all phases of CT we revealed strong negative correlation between l-HCC density and the number of vessels whereas correlation between l-HCC density and mean vessel area was strongly negative. Conclusion: We revealed decreasing in angiogenic activity in HCCs neoplastic progression and growth. CT signs correlate with HCC histological differentiation.