Public access to the ViralORFeome is available at: http://www.viralorfeome.com. Registration is not necessary, and use of the database is free. Users who want to generate viral ORF clones that are tagged with their institutional name can create an account to register. Clinical review: Primary influenza viral pneumonia Primary influenza pneumonia has a high mortality rate during pandemics, not only in immunocompromised individuals and patients with underlying comorbid conditions, but also in young healthy adults. Clinicians should maintain a high index of suspicion for this diagnosis in patients presenting with influenza-like symptoms that progress quickly (2 to 5 days) to respiratory distress and extensive pulmonary involvement. The sensitivity of rapid diagnostic techniques in identifying infections with the pandemic 2009 H1N1v influenza strain is currently suboptimal. The most reliable real-time reverse transcriptase-polymerase chain reaction molecular testing is available in limited clinical settings. Despite 6 months of pandemic circulation, most novel H1N1v pandemic strains remain susceptible to oseltamivir. Ensuring an appropriate oxygenation and ventilation strategy, as well as prompt initiation of antiviral therapy, is essential in management. As the novel swine-origin influenza A (H1N1)v global pandemic is under way, the medical community has already experienced an increase in hospitalizations from influenzarelated complications in many geographic regions. Primary viral pneumonia is recognized as the most severe pulmonary manifestation of influenza. While uncommon during seasonal epidemics, the syndrome has been well documented during the H2N2 pandemic of 1957-1958 and is thought to be responsible for much of the mortality associated with the young healthy adult population during the 1918 H1N1 pandemic [1] . This paper reviews the clinical aspects of influenza and primary influenza pneumonia that may be of most interest to the practicing physician in the 2009 pandemic environment.