Result: Compared to normal group, Col-I, HIF-1 , ICAM-1, Results: 1) Changing the diet from MCDD to MCCD triggered the reduction in fat in hepatocytes, the decrease of inflammatory gene expression and oxidative stress, and the regression of fibrosis accompanied by the disappearance of activated stellate cells and macrophages. 2) Immunohistochemistry, immunoblotting, and RT-PCR analysis all indicated the occurrence of ER stress in steatohepatitis while it recovered immediately after changing the diet from MCCD to MCDD.