In silico data obtained from this study permitted an enhanced analysis of HRV A2 strains using the ICTV criteria which assign a member to the genus Rhinovirus or Enterovirus [42] (Table 3) . The requirement common to both genera was for .70% amino acid identity in the P1 and 2C+3CD regions; this was not met by the HRV A2 genomes ( Figure 1B ). The remaining Rhinovirus species criterion was classification based on capsid-binding antiviral susceptibility and we found here, building upon earlier data [31] , that all HRV A2 strains contain a Thr 191 . This residue reportedly contributes to conveying resistance to the capsid-binding antiviral Pleconaril [4, 43] , placing the divergent HRVs into antiviral Group A [5] .