The technologies we use continue to improve and data is accumulating at an ever increasing rate. Today's microarrays represent over 18,000 genes (over ten-fold more than when we started) that together with assorted controls are arrayed as an impressive 44,000 oligonucleotides per slide. Barry Robinson is working to incorporate laser capture microdissection into our studies, which will give is our first opportunity to examine the gene expression changes that occur in specific cell types isolated from complex tissues. Bioinformatics capabilities are becoming evermore sophisticated and Jon Rue, Eric Flamoe, and Matthew Harding ensure that we stay atop the most recent advances in data management and analysis. Our Expression Array Manager database now contains information from over 7,000 expression profiles representing more than 50 million measurements of differential gene expression.