The enrichment of p87 PIKAP (also known as PIK3R6) is also interesting. This protein is a regulatory subunit of phosphoinositide 3-kinase ␥, which is part of the phosphoinositide 3-kinase signaling pathway. These pathways cover a very wide range of responses from cellular growth to cellular motility. However, activation of phosphoinositide 3-kinase ␥ is linked mainly to host-wide responses to injury or infection (64) . Indeed, it is clear that adenovirus does directly modulate the phosphoinositide 3-kinase pathway (65) .