The molecular analysis of the H10N7 Camargue strain allowed us to question whether it may exhibit some characteristics related to its circulation in an artificial environment, namely some mutations linked to increased virulence, resistance to antiviral drugs or transmission to humans. Our results do not support this assumption. The sequences of the studied segments presented typical avian characteristics. No mutation known to contribute to transmission to humans was detected. Moreover, the Camargue strain is a low pathogenic one like all viruses isolated during our research program in the Camargue since 2005 [33, 52] . No mutation conferring antiviral resistance was detected. This analysis therefore failed to highlight any risk factor linked to this particular strain. Yet, one must keep in mind that we only looked for mutations previously described in the literature, while many others may remain undiscovered so far. It is also important to stress that most experimental studies focusing on mutations modifying host specificity and virulence are carried out on chicken, although it has been demonstrated that phenotypic outcomes of a given mutation can greatly differ from one host species to another [42] .