Based on the theory that PCA can summarize most of the information from the original scoring functions, we employed PC1score to re-rank the 113,228 Surflex_score extracted poses, as mentioned above, PC1score is a linear combination of eight scoring functions (Surflex_Score, G_Score, D_Score, ChemScore, LigScore1, PLP1, Jain and Ludi_1). By the same filter protocol as the conventional consensus scoring, another 20 drug-like compounds were select for purchase among the top 300 compounds. Excitingly, this time two compounds (S450588 and 276065), with a remarkable 10% hit rate, emerged as the BACE-1 inhibitors in the low-micromolar range, showing IC 50 values of 51.6 and 85.3 mM, respectively ( Table 6 ). The chemical structures of these two compounds were showed in Table S1 .