L4 stage glp-4(bn2) and glp-4(bn2);xbp-1(zc12) worms were used for this experiment. Approximately 80,000 worms of each strain were used for both control and Cry5B treatments. Control plates consisted of 100 mm plates spread with E. coli that did not express Cry5B, while Cry5B treatments consisted of plates in which 100% of the E. coli expressed Cry5B. Approximately 20,000 worms were used per plate. Worms were fed on the bacteria for 6 hours at 20uC. For details of mass spectrometry, please see Protocol S1.