Phase I clinical trials have shown that curcumin is safe even at high doses (12 g/day) in humans but exhibit poor bioavailability. Despite the promising biological effects of curcumin, low plasma and tissue levels of curcumin due to its poor oral bioavailability and absorption, rapid metabolism and systemic elimination in both rodents and humans [36] may be responsible for the unfavorable pharmacokinetic of this molecule. To improve the bioavailability of curcumin, numerous approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; third, curcumin nanoparticles; fourth, the use of curcumin phospholipid complex; fifth, the use of structural analogues of curcumin (e.g., EF-24) [35, 36] .