The utilization of immuno-molecular recognition in the assembly of nanoscale sensors has applications in medical diagnosis, treatment, and the understanding of diseases [7] . Enzyme-linked immunosorbent assay (ELISA) is widely utilized in clinics and hospitals as an initial screening for several infectious diseases. While ELISA can be effectively employed in laboratory settings for common infectious agents, several obstacles inhibit the adaptation of this standard clinical assay to portable or select agent detection schemes. Unfortunately, pathogenic agent detection requires calibration with irradiated or otherwise attenuated samples of the organism. This requirement limits the widespread use of immunosensor diagnostics because of the scarcity of these agents and the logistic difficulty in safe transportation to remote locations. Recent cases like the development of meningitis and tularemia infections in researchers who were working with the causative agents of these diseases alert scientists to the hazards accompanying work with live calibrants [8] . The possibility of exposure and high cost are enough to warrant investigation into a safer positive control for these disease detection assays and devices. Without a positive control, the operational status of the sensor cannot be determined. Thus, the development of a nanoparticle mimic would be a safer alternative to current methodology and could be extended to address the needs of other assays that incorporate well-defined epitopes.