Host cell. In our model, the host cell provides unlimited building blocks such as nucleoside triphosphates and amino acids for the growth of virus. However, as viral components accumulate during the course of infection, some key host components for translation such as initiation and elongation factors may be depleted [28, 63, 56] . Two main viral products, leader-mRNA and M protein, contribute to the deficiency by inhibiting the synthesis of host macromolecules at the transcription level [19, 28, 35, 36] . Because leader-mRNA starts to accumulate soon after the initiation of infection, and a small amount of the component is enough to trigger the inhibition [28, 35] , the pool of host factors is continuously reduced from the onset of infection. We quantify this reduction with a single decay rate constant specific to the type of host cell: