Objective: Platelet-Derived-Growth-Factor-Receptors (PDGFR) are transmembrane tyrosine kinase receptors that function as relay points for signaling pathways. They play a key role in numerous processes that affect cell proliferation, tumor genesis, cancer invasion, metastasis, and modulation of apoptosis. Recently, PDGFR has been demonstrated to be overexpressed in Schwannoma in vivo, and in a small series of acoustic neuromas. However, its phenotypic expression in different variants of Schwannoma remains largely unclear.