The JAK/STAT and related JAK/Src pathway show a similar response to that seen for NF-kB. Of the JAK/STAT-responsive genes, only NOS2A is regulated by more than one pathway, with DgB and DgH virions inducing their transcription and DgD particles having no significant effect ( Table 2) . Although the JAK/ Src pathway has only two targets on the signalling microarraysupon which the real-time PCR experiments were based -BCL2L1 is unique to the pathway, with BCL2 expression regulated by multiple signalling routes. Interestingly, while DgB and DgH virions up-regulated BCL2 and BCL2L1, DgD virus particles appeared to down-regulate both targets by a significant amount.