Given the comparative differences we observed when locating and comparing the HRV domains, we also investigated the HRV- The deletions in the VP1 BC loop had a less obvious impact on HEV receptor footprints which were mostly located on the bsheets rather than the loop (Figure 4 ). The EF loop in HRV-QPM VP1 provided the greatest observable identity with any HEV footprint while the C-terminal sheet-loop-sheet structure may interfere with binding to the HEV receptors we investigated. All the HEV VP2 receptor footprints occured in the EF 'puff' but in this region of HRV-QPM a number of deletions and residue substitutions were apparent ( Figure 4 ) that affected the appearance of predicted structural overlap. HEV footprints in VP3 differed from HRV-QPM at the N-terminus and the CD loop due to amino acid substitutions and loop-shortening deletions but they overlapped in the GH loop.