Objective: Melanocytic lesions having subtle features suspicious for malignancy create considerable difficulty in decision-making.process. Lack of deep HMB-45 positivity and low dermal MIB-1 index can be reliable tools in association with morphology. Method: Twenty-seven acquired melanocytic lesions in which HMB-45 and MIB-1 have been performed are reviewed to determine the importance of these markers in routine diagnostic practice. Asymmetry, focal loss of maturation, presence of mitoses, epidermal consumption and lymphocytic inflammation were the morphological features that have created difficulty especially when seen alone in a bland appearing nevus.