Although it is now well recognized that SNPs in genes modulating immune response are likely to be determinants of host susceptibility to fungal infections, so far, little is known regarding the biological significance of these variants. In order to shed light into the potential functionality of Dectin-1 (rs3901533 and rs7309123) and DC-SIGN (rs4804800, rs11465384, rs7248637, rs7252229 and rs2287886) variants, we investigated whether they were involved in disruption of a binding site for critical transcription factors that might influence transcription level of these genes. Our predictive analysis showed that the carriage of the C allele for the Dectin-1 rs7309123 SNP creates a putative binding site for Cdxa, a relatively unknown transcription factor, which might be involved in the control of Dectin-1 gene expression. To assess whether the Dectin-1 rs7309123 polymorphism might be associated with a decreased expression of Dectin-1, we correlated Dectin-1 mRNA expression levels with Dectin-1 rs7309123 genotypes. Interestingly, we observed that individuals harbouring the GG genotype showed a relatively lower expression than those carrying the C allele (CC+GC). These results further supported our hypothesis suggesting that Dectin-1 rs7309123 SNP may have an effect on the Dectin-1-mediated recognition of Aspergillus conidia and subsequent immune responses. However, this predicted change in transcription activity is only suggestive at this stage and will need further validation using in vitro functional assays.