Furthermore cancer cells secrete soluble factors in the tumor microenviroment, for example, VEGF, IL-10, and TGF-β, that affect the maturation, differentiation, and activity of APCs as DCs [124] , interfering with immune cells maturation and effector properties. The tumour microenvironment may drive tumour growth and even selectively support a subset of tumour cells, the cancer stem cells (CSCs).