The single parameter assays described above offer convenient and predictive methods to view the cytotoxic land-scape of chemical libraries. When certain combinations of the assays are added as same-well multiplexes however, they provide not only complementary but additive benefit [55] . Although the concept of multiplexed screening is well appreciated for image-based technologies, it is emerging as a more viable option for plate-based, homogeneous assays because implementation is simple, accessible, and cost effective [56] .