Strengths of the proposed pilot trial design include the use of central randomization, allocation concealment, multi level blinding, standard criteria for medication discontinuation, and 90 day follow up. To ensure feasibility during a pandemic, we did not protocolize H1N1 testing, ventilator and sedation management or the clinical use of antibacterial agents. By merging study data with an Influenza Registry and capturing data on unique forms for centres not participating in the registry, we will, however, document key aspects of clinical management.