The minimal concentration of IFN-γ was detected on day 5 (14.3 ± 10.8 pg/ml), however, its levels enlarged about 8-fold (256 ± 27 pg/ml) during the course of the infection when compared with uninfected animals. On days 3 and 5 systemic production of TNF-α was below the detection limit of the assay. A peak was reached on day 7 by the cytokine (24 ± 3.2 pg/ml) and its levels remained elevated on day 8. Interestingly, concentrations of IL-1β in mice after the challenge were significantly lower in comparison with the constitutive expression of the mediator in intact animals. An abrupt decrease of IL-1β was detected on day 3 post infection, but was followed by step increase from day 5. After the 2.5-fold enlargement on day 3 the levels of IL-6 decreased dramatically on day 5, and the highest levels of the cytokine were determined at the end of observation period (133 ± 12 pg/ml). The constitutive production of IL-10 was undetectable. The dynamics of IL-10 showed a gradual growth with the maximum level (92.1 ± 6.0 pg/ml) reached before the death of mice. We observed statistically significant increase of IL-12 after the challenge. Concentrations of the cytokine retained constant in infected mice, except the unexpected decline occurred on day 7. The expression of IL-18 could not be detected throughout the entire period of observation.