SOFA scoring has previously been demonstrated on a multinational basis to predict high risk of mortality (a SOFA score of over 15 was 98.9% specific for mortality) [61] . Other critical care scoring systems show comparable performance in mortality prediction; discrimination as measured by area under Receiver Operator Characteristic (ROC) curve was 0.825 to 0.901 for Acute Physiology and Chronic Health Evaluation III (APACHE III) [62] [63] [64] [65] , 0.79 to 0.846 for Simplified Acute Physiology Score II (SAPS II) [62, 64, 66] , and 0.928 for the Multiple Organ Dysfunction Score [67] . However, calibration of these scores to give absolute risks of mortality has not always been reliable [65] and has required customisation for international use [68, 69] .