In the recent pandemic, influenza A H1N1 virus has been estimated to cause approximately 18.449 deaths in 214 different countries until August 1 st 2010 [3] . Adult respiratory distress syndrome (ARDS), along with bacterial co-infections were the direct causes of death in most cases [4] . However, no cases of viral-induced septic shock without severe pulmonary involvement have been reported. Nevertheless, little is known about this infection in SLE patients [5] . Herein, we report a case of an SLE patient, who developed septic shock due to influenza A H1N1 infection, without acute lung injury.