Similar to human changes there may be considerable variability in neuropathological changes. Status epilepticus models classically demonstrate concordant human histological changes of severe neuronal loss, granule cell dispersion, remodeling of mossy fiber structures and neurogenesis. The degree of neuronal loss is related to the concentration of inciting agent and duration of status epilepticus. Neurogenesis has been reported without corresponding cell death whereas granule cell dispersion may occur without evidence of neurogenesis (72, 98) .