Using normalized microarray data, we identified 1,486 differen-tially expressed genes (Fig. 4A) , which included 1,303, 121, 40, 20, and 2 genes exhibiting minimum 2 to < 5, 5 to < 10, 10 to < 20, 20 to < 70 and > 70-fold changes, respectively. To verify gene expression profiles determined by microarray analysis, the expression levels of 10 genes with high fold changes (2-48 fold changes, Table 2 ) were confirmed by RT-PCR.