The same experiments were also implemented with 274 PPI pairs extracted from the IntAct database [38] , and sim- Protein pairs with the false discovery rate of PCC value less than 0.1 were deemed as significantly correlated pairs. 'Significant PPIs' are pairs detected by the PPI calculation; 'Significant GGIs' are those detected by the GGI calculation. ilar conclusions were obtained. More details can be found in Additional file 6 and Additional file 7.