As previously discussed, all these genes progress towards a loss of expression, and they are highly correlated. Figure 9 shows the average expression of PKP1/Plakophilin 1 (ectodermal dysplasia/ skin fragility syndrome), (NM_000299) and JUP, Junction plakoglobin, (BX648177) on the x-axis against that of DSP, Desmoplakin (NM_004415 Hs.519873) on the y-axis. Again, we see a clear pattern of progressive reduction of expression from normal skin and nevi (green and yellow, respectively), primary melanomas (in orange) and melanoma metastases (red).