The change of expression of chemokines that mediate LFA-1 activation on PBMCs, such as CCL2, CCL3, CCL4, CCL5, CCL17, CCL19, CCL20, CCL21, CCL22 and CXCL12, was investigated on HK-2 cells after stimulation of TGF-b 1 (10.0 ng/ ml, 1.0 ng/ml and 0.1 ng/ml). Although the expression of CCL2 decreased, the expression of CCL3 and CXCL12 increased on HK-2 cells after TGF-b 1 stimulation at concentrations of 10.0 ng/ ml, 1.0 ng/ml and 0.1 ng/ml for 24 hrs in a dose-dependent manner ( Figure 2 ). The expression of CCL21 was not changed on HK-2 cells after TGF-b 1 stimulation ( Figure 2 ). CCL4, CCL5, CCL17, CCL19, CCL20 and CCL22 were not detected on HK-2 cells either before or after TGF-b 1 stimulation (data not shown).