To define appropriate criteria for determining when an interactome map is "complete", we distinguish between the terms saturation and coverage. Saturation measures the percentage of true interactions that have been experimentally observed at least once. Coverage we define more strictly to mean the percentage of true interactions that have been experimentally validated with high confidence such that the percentage of false interactions (i.e., the False Discovery Rate or FDR) is kept below a predetermined threshold. We treat "completion" as achieving 95% coverage of the Mappable Interactome at 5% FDR, which requires that the map include at least 95% of all true interactions with no more than 5% of the reported interactions being false.