Results: Seven cases of twelve (58 %) showed a BRAF-V600E mutation. Interestingly, only in three these cases (43 %) there was concordance in the mutational status between primary tumour and metastases. Moreover, all metastase of wild type carcinomas were also wyld type. Conclusion: Even with an overall good prognosis, PTC is characterized by high incidence of lymph node metastases. As BRAF mutational status correlates well with prognosis and tumour progression, a correct molecular assessment is of paramount importance. Our data may indicate that, because the possibility of discrepancy in the mutational status between primary tumour and metastases, molecular analysis should be performed on the primary tumour. Objective: Diabetes may cause chronic and non-healing diabetic foot ulcers (DFU) decreasing the welfare of patients. Some neuropeptides, Substance P and neurotensin (NT), may act as inflammatory modulators and improve wound healing. Natural biopolymers, chitosan derivatives, are receiving great attention as powerful wound dressing materials for wound healing applications due to their favorable properties. The work aim was to use 5-methyl pyrrolidinone chitosan (MPC) as a platform for the delivery of NT. Method: Diabetes was induced by intraperitoneal injection of 200 mg/kg streptozotocin. Mice were anesthetized and two 6 mm excision wounds were created dorsally. MPC alone, NT alone, MPC loaded with NT or PBS were placed daily on wounds. Histological analysis of skin, at days 0, 3 and 10, was done through H&E and Masson´s Trichrome stainnings.