Results: Macroscopy: the resected segment of the duodenal showed seven suberosal solid masses. The largest mass measured 3,5 cm×2 cm×3 cm, and is coupled with the bors lower pancreas but remains limited by a capsule. The cut surface was smooth and white in appearance. Microscopy: the tumors were composed of interlacing fascicles of the uniform spindle cells with elongated cytoplasm. The tumor cells lacked pleomorphism, and mitotic figures were absent. Immunohistochechemistry: the tumors cells were diffusely positive for CD117, CD34, and negative for desmin, AML and pS100. Conclusion: GIST are rarely noted in association with neurofibromatosis-1. Duodenal GISt are most frequently diagnosed in the workup of symptoms not specific to these masses. Duodenal resection is rarely indicated except in the case of duodenal GIST and early-stage adenocarcinoma or if the tumor appeared involve the pancreatic parenchyma on preoperative imagings.