Conclusion: ALK1 and BMP-9 overexpression may be underlying the molecular alteration that accounts for osteogenesis in PTC. Objective: Thyroid is an extremely rare site of metastases. Renal clear cell carcinoma (RCCC) is one of the most frequent primary malignancies causing thyroid metastases as a single nodule (77 %) or multiple nodules (23 %). We report the case of a 62-years-old female patient affected by multinodular goiter, who was diagnosed with RCCC, treated with nephrectomy. Method: Due to compressive symptoms, 6 years after nephrectomy, the patient underwent thyroidectomy and the thyroid was sent for histology.