In cancer patients, drug-associated ILD is most commonly observed during mitomycin, paclitaxel, docetaxel or gemcitabine therapy. Table 2 outlines the types of injury reported with these agents and their response to therapy (Buzdar et al, 1980; Chang et al, 1986; Goldberg and Vannice, 1995; Rivera et al, 1995; Ramanathan and Belani, 1996; Bookman et al, 1997; Merad et al, 1997; Piccart et al, 1997; Semb et al, 1998; Vander Els and Miller, 1998; Dunsford et al, 1999; Thomas et al, 2000; Fogarty et al, 2001; Read et al, 2002; Barlesi et al, 2004) . Acute pneumonitis, both interstitial and noncardiac pulmonary oedema pattern, has been observed with mitomycin. Response to high-dose methylprednisolone has been reported within 24 -48 h of therapy; however, approximately 60% of patients developed ongoing and persistent lung disease (Rivera et al, 1995) . Chronic pneumonitis, similar to bleomycin-type pneumonitis, has also been reported during mitomycin therapy, which responded to prednisone therapy (Buzdar et al, 1980; Chang et al, 1986) . As with bleomycin, it has been suggested that oxygen therapy be avoided during mitomycin therapy, although the evidence for this is not as established as that for bleomycin (Klein and Wilds, 1983) .