In the case of the recognition system 3/6, a close contact state along the outer helix shells results from PNA pairing and TMD assembly . The adopted peptide complexes can be considered as one reconstituted peptide species surrounded by annular lipids (Fig. 2c) . The recognition process, therefore, diminishes the peptide/lipid contact area by shielding the inner helix flanks towards the lipid matrix. In this respect, the recognition system species 3/6 (sample 5) provides lower values for a and higher values for n than the hairpin species 5 at the same P/L ratio.