Lessons learned from a systematic approach to building and sustaining a regional and local biosurveillance community of practice have been documented in a meaningful way. These lessons can and should be leveraged as more of the country engages in syndromic surveillance through meaningful use incentives and the BioSense 2.0 infrastructure. The NACCHO sponsored north central Texas APC and tools derived from their work is a proven method to provide such assistance to local health departments across the country.