From our results, we can not completely establish if the downregulation of CD40 and CD59 are enough to pinpoint an impaired or abnormal immune response. If we continue the inspection of the list, the first 20 probes give us more supporting evidence. The 20 probes correspond to 13 different genes. Five of these 13 genes have Genome Ontology information annotated as ''defense response'', the above mentioned CD59 and CD40 as well as IL4R (interleukin 4 receptor, CR616481), XBP1 (X-box binding protein 1, AK093842) and HLA-A (major histocompatibility complex class I HLA-A29.1, BU075230). Takahashi et al. [544] report an inverse correlation between XBP1 expression and histological differentiation in a series of prostate cancers without hormonal therapy, the expression of XBP1 was localized in epithelial and adenocarcinoma cells of the prostate and the majority of refractory cancer cases exhibited weak XBP1 expression), MST1/STK4 (along with MST2/STK3) act as inhibitors of endogenous AKT1, a mediator of cell growth and survival [545] .