Although the World Health Organization (WHO) has recently established new clinical guidelines to classify dengue severity [1] , serological, virological, and molecular biological tests are required to definitively diagnose DENV infection. In many endemic countries, laboratory diagnosis of dengue is often problematic due to lack of reagents, expense, or delay in obtaining results. Patients with suspected dengue are often hospitalized for close monitoring to ensure proper treatment if they begin to develop severe dengue; however, up to 38-52% are later diagnosed with OFIs [8, 9] and thus were hospitalized unnecessarily at great financial cost to their family and society [10] . New tools are therefore needed to distinguish dengue from OFIs to prevent deaths from severe dengue and to mitigate the economic burden of excess hospitalization.