Profile of HBeAg +ve Chronic HBV Infection in Bangladesh M. Mahtab 1 , S. Rahman 1 , F. Akbar 2 , F. Karim 1 , A. Shrestha 1 , M. Khan 1 , M. Kamal 1 1 Bangabandhu Sheikh Mujib Medical University, 2 Toshiba General Hospital, Dhaka, Bangladesh Background: Inactive HBV carriers constitute the major reservoir of HBV. Present management guidelines provide inadequate treatment modalities. They are recommended for regular check-up; treatment is only recommended when patients exhibit evidence of liver damage. This is due to lack of information about their extent of liver damage. Aim of this study was to assess extent of liver damage in HBeAg +ve patients, unaware of their infection. Methods: In this retrospective study, records of 206 HBeAg +ve CHB patients from our pool of 561 CHB patients were reviewed. They were tested for HBsAg, HBeAg, HBV DNA, anti-HCV and serum ALT. All underwent per-cutaneous liver biopsy. Results: 78.2% (161/206) patients were males and 21.8% (45/206) females. They were between 8-45 years of age. ALT was raised >2times UNL in 17% (35/206). 92. 2% (190/206) patients had high HBV DNA (>10 5 copies/ml), while low HBV DNA (<10 5 copies/ml) was seen in 7. 8% (16/206) . In high HBV DNA group, significant necro-inflemmation (HAI-NI >7) was seen in 48. 9% (93/190) and significant fibrosis (HAI-NI >3) in 24. 7% (47/190) . Figures were 37.5% (6/16) and 31.3% (5/16) respectively in low viral load group. None tested positive for HCV infection.