Ginseng is another herb with potent anti-inflammatory effects. An extract from Korean red ginseng (Panax ginseng, C.A. Meyer) significantly protected mice in experimental sepsis by decreasing TNF, IL-1, IL-6 and IFN-g production via inhibition of NF-kB activation (53) (54) (55) . It is likely that Korean ginseng will also reduce HMGB1 levels, because cytokines under the control of NF-kB, such as TNF and IFN-g, induce HMGB1 (56). Green tea (Camellia sinensis) reduces endotoxin-induced release of HMGB1 and is also proposed to possess the ability to decrease mortality from sepsis if taken regularly (57) .