Functional IFITM gene sequences were gained based on orthologous and paralogous relationships by querying the Ensembl genome assemblies (http://www.ensembl.org/index.html) using known authentic IFITM genes [17] . Collected IFITM genes were used as queries to search against known IFITM gene datasets using tBLASTn or BLASTn searches to make sure the best hit is an functional IFITM genes with E value,10 210 . The presence of CD225 domain in each obtained IFITM protein sequence was confirmed using P-fam database (http://pfam.sanger.ac.uk).