A potential role of host genetic factors in the predisposition to HIV-1 infection has been suggested by different reports [8, 31, 32] . DC-SIGNR serves as an HIV-1 ligand to facilitate HIV-1 virion infection into adjacent CD4+T cells in trans and has been the subject of many recent studies. The VNTR polymorphism in its neck-region was found to be associated with host susceptibility to HIV-1 infection, but the conclusions were controversial.