The prevalence of different forms of organ damage in our study population was: pulmonary hypertension (PHT): 24.5%, renal failure: 3.2%, microalbuminuria: 21.3%, retinopathy: 31.2%, iron overload: 9.6%, avascular osteonecrosis: 11.7%, leg ulcers: 6.4%, Acute chest syndrome (ACS): 25.5%, priapism: 8.5%, and stroke: 4.3%. Except from lower QoL scores (for the PCS) in patients with iron overload (P 5 0.017), no association between any form of organ damage or sickle cell-related complications and QoL scores was found (Table III) . Moreover, when patients with organ damage and complication were divided according the pathogenesis (hemolysis-related complication versus vaso-occlusion/ischemia-related complications), no significant differences in QoL was observed when compared with the patients without organ damage at all.