The best-characterized raft proteins include lipid-modified proteins containing saturated acyl chains, such as GPI-anchored proteins, and doubly acylated proteins, such as Src family kinases and the α subunits of heterotrimeric G proteins (Hooper, 1999; Liang et al., 2001; Oh et al., 2001) . Many other physiologically important proteins have been investigated for their possible raft localizations, including key proteins involved in Alzheimer's disease (AD), such as amyloid precursor protein (APP; Parkin et al., 1999) , β-site APP cleaving enzyme (BACE-1; Ehehalt et al., 2003; Kalvodova et al., 2005) , the γ-secretase complex (Hur et al., 2008) , a disentegrin and metalloprotease ADAM10 (Harris et al., 2009), acetylcholinesterase (AChE; Xie et al., 2010b) , angiotensinconverting enzyme (ACE; Parkin et al., 2003) , a ligand for the Notch receptor (Jagged1; Parr-Sturgess et al., 2010) , and most recently an amyloid β (Aβ)-degrading enzyme, neprilysin (NEP; Sato et al., 2012) . However the full list of raft-associated proteins is still far from completion.