Methods: Zucker rats lean (200±10gms) and obese (450±15gms) were divided into control and acute hypoxia groups. The acute hypoxia treatment was performed in a hypoxic chamber at 14% oxygen consumption. Objectives: To compare the diagnostic value of morning urine copper to zinc (Copper/Zinc) ratio and 24 hour urinary copper excretion in Wilson's disease (WD) children.