We observed one co-infection with HRV-A and HRV-B (N16A and N16B), one with HRV-A and HRV-C (N58A and N58C), and three co-infections of HRV-A and HRV-B with HEVs that may favor recombination events. Previous comparison of genome sequences between 34 HRVs showed only limited recombination events and a pattern of genetic diversity lower than that observed with other picornaviruses [25] . The presence in HRV-C subspecies of sequences that share 90.5-98.6% identity with HRV-A strains (Table 3) suggests that recombination events occurred between HRV-C and HRV-A. Bootscanning of the 59UTR of HRV-C strains also showed different sites and lengths of recombination (Fig. 3c) , which suggested that there were several independent events that led to several groups of HRV-Ca genotypes, which formed clusters in the phylogenetic tree (Fig. 2) .