CHIKV resolution is associated with differential cytokine programs of increasing and decreasing trends CHIKV causes a disease of crippling joint pain that has affected most of Asia and has demonstrated the capability to spread to nontropical areas such as Europe and parts of North America [1] . Cytokines are inflammatory mediators and their balance is often associated with inflammatory disease [23] . Previously, the cytokine profiles of acute phase CHIKV patients have been examined [22] . Here we profiled cytokine levels in acute phase and 6-and 12month follow-up CHIKV patient serum samples to determine a cytokine signature that may correlate with acute symptoms, following persistent joint pain and/or disease resolution. Blood samples were collected from 50 patients suffering from CHIKV infections during the 2007 Italian outbreak. Serum separated from whole blood was analyzed by cytokine bead analysis (CBA) for 13 cytokines with the intention of determining a cytokine profile during CHIKV acute phase and disease convalescence. Three cytokine profiles emerged from our data: decreasing, increasing and no-trend.