In this study we evaluate the immunogenicity of mammalian cell-derived VLPs containing structural proteins (core, E1 and E2) of HCV genotype 1a when delivered directly to dendritic cells (DCs) using a Toll-like receptor 2 (TLR2) targeting lipopeptide. This lipopeptide contains the TLR2 agonist dipalmitoyl-Sglyceryl-cysteine (Pam 2 Cys) and associates electrostatically with protein antigens significantly improving their ability to induce both humoral and cell-mediated responses [23] . The ability of lipopeptide-VLP complexes to facilitate DC uptake, induce antibody capable of inhibiting VLP entry into target cells and to elicit cell-mediated antigen-specific responses were each determined.