For more than 50 years aromatic diamidines and related dicationic molecules have been extensively used but so far only pentamidine [12] [13] [14] [15] has been widely employed as a drug in humans despite several adverse effects, such as hypotension, abdominal pain, vertigo, hypersalivation, hypoglycemia, nausea, and mild nephrotoxocity [5] [6] [7] [8] . Being a highly flexible molecule that can assume an array of linked conformations related through torsional rotation, changes can be made in the nucleus to produce improved analogous against HAT. In line to this with an aim to increase the efficacy and decrease the side effect related to pentamidine various research groups have made several changes in the pentamidine molecule [16] [17] [18] [19] [20] [21] [22] [23] 