To account for multiple testing, we used the Bonferroni correction and a statistical significance was considered only when an SNP association with T2D/metabolic traits was p,0.017 (equivelent to 0.05/3), and a haplotype association with T2D/ metabolic traits was p,0.0125 (equivelent to 0.05/4). The human plasma apoM concentrations determined by dot-blot assays were compared by a nonparametric Kruskal-Wallis H test. A value of p,0.05 was considered significant.