In a majority of patients, IL-7 plasma level, sj/bTREC ratio, sjTREC/ml and blood RTE concentration fluctuated in parallel ( Figure S2 ). Variation of IL-7 plasma concentration (DIL-7) during the first month of therapy correlated with variations in naïve T-cell counts (CD4+ + CD8+; DNaïve T-cell counts) and RTE CD4+ T-cell counts (DRTE T-cell counts) in both HCV (r = 0.521, p = 0.039 and r = 0.595, p = 0.025; Figure 5A and 5B, left panels) and, to a lesser extent, HIV/HCV co-infected patients (r = 0.636, p = 0.048 and r = 0.539, p = 0.108; Figure 5A and 5B, right panels). Moreover, in HCV-infected patients, DIL-7 also correlated with variations in intrathymic precursor T-cell proliferation (Dsj/bTREC ratio; r = 0.601, p = 0.020; Figure 5C ).