(33.8 vs 6.1 average mast cell count/10 high power fields; p < 0.01) ( Figure 2 ). The increased number of mast cells in patients with painful pancreatitis was noted predominantly in interstitial areas and, to a lesser degree, in the periacinar space. Figure 3 shows the post-pre surgical response frequency for both WT and MCDM. TNBS had a significant independent effect on abdominal VFF response in WT mice at the force levels 4 and 8 mN (p = 0.007 and 0.037, respectively) ( Figure 3A ). There was a trend towards a significant effect at the force level of 16 mN (p = 0.066). In contrast, for MCDM, TNBS had no significant effect on abdominal VFF response at any force level ( Figure 3B ). There was no significant TNBS effect on VFF response in the left A g e 