Low-quality (high error rate) draft NN data, however, yield results that are very similar to those with high-quality draft or finished NN data, as long as the target sequence information is of intermediate to high quality ( Figure 5C -D andFigure 6): At least four NN sequences are necessary to ensure that signature regions are unique, whether the NN data are low-or highquality draft or finished. That is, our simulations indicate that low-quality draft NN data are adequate for predicting DNA signatures, as long as there is good quality target sequence data. This results because errors in the NN sequences occur at random locations that differ in each NN sequence. As long as at least one of the NNs has enough correct sequence to eliminate each of the non-unique target regions, then the unique regions of the target can be determined.