The inspired fraction of oxygen (FiO 2 ) which, before intrapulmonary administration of rFVIIa had been 1, was reduced to 0.6 during the first three hours subsequent to the administration of rFVIIa, and to 0.4 over the following 24 hours (figure 1). Haemoglobin readings remained unchanged without the need for blood transfusion. Although there were no new episodes of active DAH, weaning from ventilator was retarded due to muscular weakness. The patient was extubated at day 16 in the ICU and discharged to stationary ward without recurrent bleeding.