For E-Predict, default values for all parameters were used, and are shown in Table 2 . Data points were corrected for local background, as per the examples in Urisman et al. [9] . E-Predict filters out 266 oligos by default, and this setting was kept. In all cases, E-Predict carried out two iterations, although only results from the first iteration are shown here. The best performing method of interpreting the results was to take those species with a p value ≤ 0.05 and sort by distance (termed E-Predict.dist). Note that this is the method cited in [9] , example 3, used to demonstrate E-Predict's ability to detect SARS.