In the spring of 2009, a novel influenza A(H1N1) virus rapidly spread worldwide, resulting in the first influenza pandemic of the 21st century [1] . Critically ill cases caused by 2009 H1N1 virus retrospectively showed that most had progressed or died due to ARDS [4, 6] . However, the pathogenesis and therapeutic intervention of ARDS caused by 2009 H1N1 infection have still not been elucidated. Animal models of disease are important for characterizing pathogenesis and developing the preclinical evidence for revised approaches to ventilating patients with ARDS [19] . Here, we present a mouse model for the study of ARDS induced by SD/09 virus, a virulent 2009 H1N1 variant.