Induction of this pathway may be responsible for the upregulation of CCND1, MYC, BCL2 and MMP7 after inoculation with DgB and DgH but not DgD HSV-1 ( Table 2 ). Differential expression of CCND1 and MYC can be regulated by the Wnt and PI3K signalling pathways, with MYC also being controlled by Protein Kinase C. The up-regulation of MMP7, which is the only target unique to the PI3K pathway that is differentially expressed, highlights the potential crosstalk between signalling pathways and cannot exclude the involvement of PI3 kinase signalling as a pathway leading to transcription of all four cellular genes.