Hepatocyte models were proposed as a platform for screening of herbal 6 Evidence-Based Complementary and Alternative Medicine component against ethanol hepatotoxicity. Nanosilibinin, for the first time, found to perform significant protection against ethanol-induced hepatotoxicity while silibinin in normal particles could not inhibit such toxicity. This protection of nanosilibinin might be related to its high bioavailability compared to normal insoluble silibinin and could act as an antioxidative and antisteatosis agent against ethanol-induced hepatotoxicity [54] .