In addition, in an ongoing parallel set of experiments, using a Gene Set Analysis (GSA) approach using the web tool Disease/Phenotype web-PAGE, in the analysis of orthologous microarray data (De S, Zhang Y, Garner JR, Wang SA, Becker KG: Disease and phenotype gene set analysis of disease based gene expression, unpublished), both the human and mouse disease/phenotype gene sets defined above demonstrate striking disease specificity in PAGE [61] gene set analysis of previously published microarray based gene expression studies from numerous independent laboratories in both a species specific and cross species manner. This was true when studying gene expression studies of type 2 diabetes, obesity, myocardial infarction and sepsis, among others, providing further evidence of the disease and clinical relevance of both the human and mouse gene sets.