Rs1800629 was not associated with mortality among subjects with severe sepsis in our study. This was consistent with the study by Stuber et al., which demonstrated that the rs1800629 genotypes were not associated with poorer prognosis in severe sepsis. However, they did not find an association between rs1800629 genotypes and plasma TNF-a levels [26] . Recently, Teuffel et al. conducted a systematic review and meta-analysis, which also concluded that rs1800629 (TNF 2308 AA/AG, TNF2) was associated with susceptibility to sepsis, but not with sepsis mortality [29] .