Results: IUGR vs SH pups weights were 17 % lower. HF diet caused excess weight gain, dyslipidaemia, hyperinsulinaemia and mild glucose intolerance not further aggravated by IUGR. Markedly abnormal islet morphology was evident in 0/6 SH-CH, 5/8 SH-HF, 4/8 IUGR-CH and 9/9 IUGR-HF rats (chi-sq, p=0.008). Abnormal islets were characterised by larger size, irregular shape, peri-islet inflammation with CD68 positive cells and marked haemosiderosis. Overall beta-cell mass was not altered by IUGR, with a trend for it to be mildly increased in both HF-fed groups. Conclusion: HF and IUGR independently and together contribute to islet injury. The marked islet haemosiderosis associated with IUGR and HF diets warrants further investigation as iron is toxic to β-cells. Objective: Adreno-hepatic fusion (AHF) is defined as adhesion of the liver and right adrenal gland with or without a fibrous capsule dividing both organs. We report a surgical case of AHF in which a virilising malignant adrenocortical tumour protruded into the liver mimicking a hepatic mass. Method: A 36-years-old woman presented with mid-right abdominal pain and marked hirsutism. Computed tomography (CT) revealed an apparently intrahepatic solid tumour suggestive of a giant hepatic adenoma. The right adrenal gland was not visible on CT and the right kidney showed marked downwards displacement. A radical right adrenohepatectomy was performed, with a satisfactory outcome.