A single study by Eun et al (25) attempted to analyze human temporal lobe specimens in patients with MTLE undergoing surgical resection by performing 2DE and Western blotting of the selected proteins. Control specimens were obtained from lateral temporal cortices of patients undergoing temporal lobe operations for tumors in the absence of seizures. This study reported significant changes in nine proteins with particular emphasis on proteins related to oxidative stresses; it also highlights the shortcomings in performing comparative studies in humans with control specimens coming from a variety of different diseases such as glioblastoma multiforme (7), sphenoid wing meningiomas (3) and malignant lymphomas (2) .