We also performed a comparative analysis of FM data-set obtained in this study with our previously published VM data [15] . Clustering of the three experimental groups (FM, VM and HC) was performed by principal component analysis (PCA) using an algorithm included in the extended data analysis (EDA) module of the DeCyder software. Proteins present in at least 80% of the spot maps and passed the filter of the one-way ANOVA (p,0.01) test were included in this multivariate analysis. Additionally, a hierarchical cluster analysis was performed using the same protein selection criteria.