SLiMs play an important role for many regulatory processes such as signal transduction, protein trafficking and post-translational modification (3, 4) . Their importance to the correct functionality of the cell is also reflected by the outcome of motif deregulation. For example, point mutations in SLiMs have been shown to lead severe pathologies such as 'Noonan-like syndrome' (5) , 'Liddle's syndrome' (6) or 'Retinitis pigmentosa' (7) . Furthermore, mimicry of linear motifs by viruses to hijack their hosts' existing cellular machinery plays an important role in many viral life cycles (8) . However, despite their obvious importance to eukaryotic cell regulation, our understanding of SLiM biology is relatively limited, and it has been suggested that, to date, we have only discovered a small portion of the human motifs (9) .