All the compounds investigated need not the treatment for neutralization before using QikProp because it will be automatically done in QikProp. The normal mode was applied in the program. The property analyses for the partition coefficient (QP logP o/w), van der Waals surface area of polar nitrogen and oxygen atoms (PSA), predicted aqueous solubility (QP logS b ), and apparent MDCK permeability (QPP MDCK c ) [70] , were considered in the QikPro to evaluate the acceptability of the compounds.