We will now address another non-coding RNA called NEAT1 which, like NEAT2, is also conserved in the mammalian lingeage. Before we move onto NEAT1, we will first recall a previous result. We have noted before the conspiquous position of SFPQ/PSF (Polypyrimidine tract-binding protein-associated splicing factor) in Figure 16 . The expression of a probe for SPQF has the highest correlation with the values of the Normalized Shannon Entropy. We highlighted before that SFPQ/PSF is a putative regulator of growth factor-stimulated gene expression [498] . The loss of SFPQ expression during the progression of prostate cancer may be an important key to understand this disease or one of its subtypes. We have also mentioned that the AR/PSF complex interacts with the PSA gene (perhaps the most well-established prostate cancer biomarker) and that SFPQ/PSF inhibits AR transcriptional activity [499] . Kuwahara et al. showed that SFPQ together with NONO (Non-POU-domain-containing, octamer binding protein) and PSPC1 (Paraspeckle protein 1 alpha isoform, formerly known as PSP1) are expressed in mouse Sertoli cells of the testis and form complexes that function as coregulators of androgen receptormediated transcription [500] . While new research results [759] link SFPQ and NONO/P54NRB with the RAD51 family of proteins (largely regarded as another key protector of chromosome integrity as being involved in homologous recombination DNA repair), it is perhaps SFPQ and NONO's co-localization in paraspeckles that make this group also remarkable [760] .