Goblet cells produce and secrete mucins, which are important glycoproteins in the mucociliary transport system of the middle ear and are the main component of middle ear effusions, responsible for the viscous properties of effusions. 51, 52 However, under disease conditions, alterations that occur in the middle ear and eustachian tube mucin metabolism, 53 in the structure of mucin glycoproteins 54, 55 and in the glycoconjugate expression in cilia and goblet cells 56 promote the dysfunction of the normal mucociliary transport system and the formation of effusion in the middle ear cleft.