Since a prodrug of furamidine, 2,5-bis[4-(N-methoxy)amidinophenyl]furan (pafuramidine), has shown promising results in clinical trials against HAT [36] , therefore Furamidine ( Figure 11a ) has gained attention for further evaluation to produce newer antitrypanosomal analogous. Two other analogues of furamidine (Figure 11b &c) have been evaluated against T. b. rhodesiense mouse model and have shown promising results. One approach to enhance the activity of furamidine has been the replacement of the central furan ring with other heterocyclic systems, including thiophene, pyrrole, oxazole, oxadiazole, thiadiazole, pyridazine, methylpyrimidine, and triazine [37] [38] [39] [40] [41] . Such structural modification in past has resulted into compound with good anti-parasitic activity. For example in 1977 Boykin DW and Das PB have reported the synthesis and antiprotozoal activity of eighteen substituted 2,5-bis(4-guanylphenyl)furans and related analogues, including "masked" amidines in which the guanyl function was incorporated into a heterocyclic ring. Among these, six compounds have produced cures in mice at submilligram dosage levels and have been somewhat more active in this screen than stilbamidine, hydroxystilbamidine, and pentamidine. . 11 . Structure of furamidine and its analogue that have shown promising antitrypanosomal properties