Peripheral blood samples were obtained from two healthy adult donors who were infected by DENV during foreign travel. The dengue neutralization profiles confirmed previous primary DENV2 (Donor 013) and DENV3 (Donor 033) infections (Table  S1 ). From both donor hMAbs were produced as previously described [32] . B-cells producing DENV specific antibody were identified by screening culture supernatants by flow cytometry for antibodies that bound to C6/36 insect cells infected with DENV2 (Donor 013) or DENV3 (Donor 033) [32] . A secondary screen to identify antibodies that bound to the rE was performed by ELISA as previously described [32] .