In some xenotransplantation studies, cyclosporine A (CsA) was administered as an oral solution diluted with corn oil at a concentration of 10 mg/ml. The CsA was administered p.o. via gavage at a dose of 75 mg/kg/d, beginning 1 day before CLP and continuing for another 24 hours after the procedure. 14 Pilot experiments demonstrated efficiency of this dosage in inhibiting production of IL-2 and IFN-␥ by T cells isolated from mouse spleens.