Urinary levels of Ang II were measured using a commercial peptide radioimmunoassay (RIA) kit that contains an Ang IIselective polyclonal antibody and 125 I-Ang II (Peninsula Laboratories, San Carlos, CA, USA), essentially as described [16, 17] . Ang-(1-7) levels were measured using a commercial peptide enzyme immunoassay (EIA) kit that contains an Ang-(1-7)-selective polyclonal antibody (Peninsula Laboratories) [16] . For assay details, see Text S1.