We envision that physicists may find here a fertile ground to explore new ideas and attempt novel mathematical formalisms for cancer progression from the realm of finite-state thermodynamics [625] and in particular endorevesible processes [626] and endoreversible thermodynamics [627] . Some molecular alterations would then be part of the set of revesible processes that could occur in a cancer cell, while other processes like aneuploidy or gene fusions could be truly ''irreversible genetic switches'' associated with cancer progression [628] . If we assume that the process is slow (i.e. the times required for significant variations of the transcriptome's profile is large in comparison with the cell's processes time scales), and follwing the results of Spirkl and Reis [626] , it may be possible that we have a constant entropy production rate exists during cancer progression leading to Hauptmann's ''entropic devolution'' [629] . Hauptmann sees a malignant tumour as ''a dissipative structure arising within the thermodynamical open system of the human body'' that starts when ''a localized surplus of energy exists and there is no possibility to export entropy. An energetic overload in most malignant cells is indicated by their abnormally high phosphorylation state.'' His perspective, preceeded in part by Dimitrov [630] , Klimek [631, 632] and Marinescu and Viculetz [633] might then fit well an endoreversible thermodynamic formalism. Hauptmann says in [629] ''I believe that cancer is a special kind of adaptation to energetic overload, characterized by multiplication and mutation of genomic DNA (generation of new biomolecules which enhance the probability of survival under harmful conditions), and by chiral alterations (reduction of entropy by entrapping energy) leading to abnormal configurated biomolecules. In this regard the genetic alterations are probably secondary changes. Cancer serves to dissipate energy in a type of developmental process but one in which the results are harmful to the whole organism: an entropic devolution.'' This thermodynamical perspective is now worth exploring and we will discuss it in this context. Assuming that a cancer cell is in a state of ''energy overload'', without ''the possibility of exporting entropy'', could it lead to some type of ''genetic alterations''? Which key mechanisms might be impaired? What consequences is this ''system'' delivering? Could this be another hallmark for oncosystems indentification?