Statins are a class of drugs which inhibit HMG CoA reductase, a key enzyme in the biosynthesis of cholesterol. Given the links between cholesterol and AD, it is not surprising that there are multiple investigations on the effects of statins in AD pathology. The current state of the field and problems have been recently discussed and the role of statins has been reviewed Wood et al., 2010) . The authors point out that the effects of statins are not only related to APP processing nor specific for the AD pathology. Furthermore, the physiological effects of statins are not solely due to inhibition of cholesterol biosynthesis but include perturbation of other mevalonate-dependent pathways such as protein prenylation.