Oxidative stress has an important role in the development of the systemic inflammatory response [133] . Honokiol, a low molecular weight natural product, is an effective antioxidant and also presents anti-inflammatory and antitumor properties [134] . However, the precise mechanism of action of honokiol on septic acute lung injury remains unclear. Weng et al. [135] observed that honokiol administered after the onset of sepsis reduced acute lung injury and prolonged survival via the amelioration of oxidative stress in endotoxemic mice.