COMBINED ENZYME-REPLACEMENT AND SUBSTRATE-REDUCTION THERAPIES IN GAUCHER DISEASE TYPE II/III Gautschi M 1 , Nava E 2 , Goeggel Simonetti B 2 , Nuoffer JM 3 1 Interdiscipl Metab Unit, Univ Child Hosp, Bern, Switzerland 2 Neuropediatric Unit, Univ Child Hosp, Bern, Switzerland 3 Institute Clin Chem, University Hospital, Bern, Switzerland