This review briefly summarizes progress related to inexpensive antimalarial drug development on three fronts: Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria It is a comprehensive picture of all three that teaches us how to circumvent quinoline antimalarial drug resistance. To date, three of the best five antimalarials of all time have been quinolines, and recent work suggests that, with a comprehensive understanding, additional inexpensive, effective quinolines can be developed quickly.