In 2-week-old birds, at 4 dpi, infection of APMV-1 strain BC was found in all of the tested tissues, including the brain, and LaSota was detected in all of the tested tissues except the brain. APMV-3 also was detected in all of the tested tissues including the brain. Replication of the other APMVs was restricted to the trachea and lungs. In general, virus titers in the 2-week-old chickens were lower than in the 1-day-old chicks. By 10 dpi, no virus could be detected in any of the tissues in any of the infected chickens for any serotype by virus isolation, suggesting that the virus was cleared from all tissues and disease was resolved, indicating the self-limited nature of the infections.