Cyclin-dependent kinase 2 (CDK2) is one such downstream target of c-Myc activity, as well as the Androgen pathway, highlighting the signalling cross-talk that may occur [44] . CDK2 is involved in the progression of the cell cycle from G1 through to S phase. Transient activation of CDK2 was shown to occur early in HSV-2 infection at two hours post-infection, and is crucial in early HSV-1 infection [45] [46] . Kinase action by the cyclin A/CDK2 complex liberates the bound transcription factor E2F from Rb, a transcription factor that has previously been shown to be active during HSV-1 infection [47] .