Acute HBoV infection was found in children with bronchiolitis. Among children <2 years of age, acute HBoV infection was detected in 26 (27%) of 95 children having their first wheezing episode and in 35 (25%) of 141 children having their first or recurrent wheezing episode, excluding asthmatic children (defined as children considered for initiation of daily long-term control therapy according to the recent US guidelines for diagnosis and management of asthma [21] ). Children with HBoV and RSV single infections showed a similar overall severity of illness (median 7, range 4-10 on a scale of 0-12), whereas acute otitis media (AOM) was more frequent among children with RSV single infections (p = 0.0005) ( ‡A child with 1 PCR-positive nasopharygeal aspirate and a PCR-negative serum sample was classified as having a subacute HBoV infection. In Table 1 , he was 1 of 3 nonviremic children with a serodiagnosis for HBoV infection. §Unadjusted. ¶Adjusted for age.