Methods: 60 SD rats were divided into 6 groups, normal control groupAmodel groupB, SQG largeC1, middleC2small dose groupsC3 and silymarin positive contrast groupD. The rats of BC1C2C3D were injected with carbon tetrachloride for 8 weeks. The rats of C1C2C3 were then administered with SQG for 8 weeks. The rats of D were then administered with silymarin for 8 weeks. Results The liver structure of rats of B was severely damagedlarge amount of liver cells became obviously degeneratedand hepatic veins were clearly congested. The hepatic cells fatty degeneration and infiltration of inflammatory cells in rats of C1C2C3D reduced significantly. There was no fiber hyperplasia in liver tissues of rats of C1C2C3D. Blood serum HA CP P levels in rats of B were significantly higher than those in AC1C2C3D. Conclusion: SQG has remarkable therapeutic effects on rats with hepatic fibrosis induced by carbon tetrachloride, the higher the dosage of SQG was, the more effective the results would be. Conclusions: None of sophisticated biomarkers had value in addition to readily available laboratory data for the prediction of significant fibrosis in HBeAg positive patients. Two markers out of 7 sophisticated biomarkers provide additional diagnostic information in HBeAg negative patients. Before new biomarkers are accepted, their superiority to routine laboratory data should be meticulously appraised.