Epidemic AGE is a major contributor to the global burden of morbidity and mortality. Rotavirus and norovirus epidemics present a significant burden annually, with their predominant impact in temperate climates occurring during winter periods. Annually, epidemic rotavirus causes an estimated 600,000 deaths worldwide and 70,000 hospitalizations in the United States, primarily among children younger than 5 years (1). The U.S. burden from norovirus is estimated at 71,000 hospitalizations annually, with the impact more generally across age groups (2) . Changes in rotavirus vaccine use have significantly reduced the impact of epidemic rotavirus (3).