Association with dysregulation of inflammatory response (2107), alteration of NLRP3 mRNA stability and enhancer activity [33, 34] HLA Various alleles Influenza-specific CTL responses exhibit varying frequency and magnitude across various HLA alleles [35] times higher than that reported for local North American Caucasian populations [26, 27] . Given the small sample size available in this cohort, further studies will be required to conclusively determine the impact of CCR5 deficiency on pH1N1 susceptibility and severity.