FMDV is a single stranded (ss) positive sense RNA virus with the whole virus particles having sedimentation coefficient of 146S [13] and genome of ∼8. 5 Kb size. The genome is polyadenylated at 3 end and carries a small covalently linked protein, VPg at 5 end [13] . The 5 untranslated region (UTR) contains a short fragment called S-fragment, a poly (C) tract followed by large (L) fragment of over 700 bases. Functionally, the genome can be categorized into three main regions: (a) 5 noncoding regulatory region, (b) polyprotein coding region (subdivided into L, P1, P2, and P3), and (c) 3 noncoding regulatory region. The translation initiation starts at two AUG codons separated by 84 nucleotides following the Internal Ribosome Entry Site (IRES). The viral genome is translated as a single polyprotein, which is posttranslationally cleaved by viral proteases [14] into four structural proteins (VP1, VP2, VP3, and VP4) and several nonstructural proteins (L, 2A, 2B, 2C, 3A, 3B, 3C, and 3D) [15] . The P1 region of genome encodes the 4 structural proteins VP1, VP2, VP3, and VP4 encoded by 1D, 1B, 1C and 1A genomic regions, respectively, [13] . Sixty copies of each structural protein (VPl-4) assemble to form the capsid [13] . Among which VP4 is internal whereas others are exposed on virion surface [16] . The 3 surface exposed capsid proteins carry the neutralizing antigenic sites [17] . Among the 4 structural polypeptides, VP1 is the most immunogenic protein of FMDV [18] having its G-H loop protruded from the surface [19] , and is maximally exposed on the capsid surface [16, 20] forming large part (54%) of virus surface [21] .