TGF-b, produced by T cells, platelets and monocytes, plays an important role in regulation of the inflammatory processes and in tissue reparation. The effects of TGF-b depend on the differentiation state of the responsive cells. 14 TGF-b, as well as IL-10, participates in resolution of acute inflammation by inhibiting antigen presentation and cytokine production in macrophages, 15 and suppressing proliferation of T cells and NK cells and cytokine production in activated T cells. 14 Simultaneously, TGF-b recruits monocytes to the site of inflammation and upregulates their pro-inflammatory activity; secretion of cytokines and growth factors, in particular. 14 The contradictory effects of TGF-b on monocyte/macrophage lineage, such as up-regulation of monocyte functions and deactivation of macrophages, demonstrate the highly coordinated role of TGF-b in regulation of inflammatory responses.