The presented work demonstrates that c-secretase is capable of influencing single gene transcription. However strong the impact will prove to be on the protein level of each single gene, we have further observed transcriptional effects spanning several genes throughout clearly defined pathways. This puts forth the possibility of much stronger effects on the target functions of these pathways than the small impact on the individual genes transcriptional or translational levels might indicate. In support of this hypothesis, we have observed that the proteins encoded by those genes interact with each other and are part of the Wnt pathways. Evaluation of the impact of these pathway-specific accumulative effects needs further investigation. This should include physiological and pathological in vivo experiments on both the transcript as well as protein levels. For c-secretase to serve as a therapeutic target, it is indeed crucial to sharpen our view of its role and influence over gene transcription and biological functions.