Pancreatic histology confirmed the presence of chronic pancreatitis in both WT and MCDM with marked fibrosis, inflammatory infiltrates and ductular proliferation mimicking changes seen in human chronic pancreatitis ( Figure 5A ). The pancreas of saline treated controls was normal. There was no significant difference in the overall inflammatory scores between the WT and MCDM ( Figure  5B ). An increased number of mast cells were counted in WT mice with chronic pancreatitis compared to saline Histology (Giemsa) of mice with chronic pancreatitis (Figure 6 ). As to be expected, no mast cells were present in pancreas of MCDM.