Consistent with this result, we and others (Markossian et al. 2006; Chang et al. 2007; Deng et al. 2007; Race et al. 2007; Broomell et al. 2008; Brown et al. 2008; Chebotareva et al. 2008; Iseli et al. 2008; Moncrieffe et al. 2008; Paz et al. 2008; Sivakolundu et al. 2008; Wang et al. 2008; Eronina et al. 2009; Mortuza et al. 2009 ) have regularly used full high-resolution grids (such as 10 9 50, 10 9 100, or higher) in SEDFIT on ordinary personal computers or laptops, an exercise that is a regular part of the Workshop on Hydrodynamic and Thermodynamic Analysis of Macromolecules with SEDFIT and SEDPHAT at the National Institutes of Health (Schuck 2009 ). This is possible due to the fact that the memory requirement for the high-resolution grid would be 48-286 MB to store the model data (assuming 50 scans for data absorbance or native interference data modeled with a 10 9 100 grid). It is readily verified that, even for the complete high-resolution grid and when globally analyzing many experimental data sets, this is well below the memory limit of currently common 32-bit Windows operating systems.