Results: Presented data show that Caucasian patients with ongoing hepatic fibrogenesis (mean 6.2 ± 5.9 µg/L) display impressingly higher serum concentrations of 15-d-PGJ2 than healthy probands (mean 2.3 ± 1.0) and Caucasian patients with non-liver disease (mean 2.7 ± 1.4 µg/L). Similar results are found in Chinese patients with fully developed HCC (mean 1.3 ± 0.7 µg/L) compared to Chinese healthy controls (mean 0.4 ± 0.2 µg/L). We identified the predictors of tumor recurrence using Cox-regression model.