Objective: We assessed topography and characteristics of blood vessels in triple-negative breast cancer (TNC) and examined their association(s) with clinicopathological features, basal-like phenotype and influence on patient prognosis. Method: Blood vessels were assessed in tissue sections from 133 TNCs stained for CD34. Slides were scanned using ScanScope® XT and analysed with Aperio Image-ScopeTM, Microvascular Density v1 algorithm. Microvessel density (MVD) was assessed in three areas: intratumoural (IT), peripheral tumoural (PP) and peritumoural (PT), and correlated with clinicopathological features and prognosis. Results: The majority of blood vessels were located largely at the peripheral tumoural and peritumoural areas. Tumours with higher total MVD and PT-MVD were significantly associated with the presence of recurrence (p = 0.05; 0.01), distant metastasis (p = 0.01; 0.005), hematogenous metastasis (p= 0.006; 0.01); and shorter overall survival (OS; p= 0.006; 0.01) and disease free interval (DFI; p=0.04; 0.09). High PT-MVD correlated with a higher stage at diagnosis (III and IV; p= 0.02), lymph node (LN) metastasis (p=0.04), basallike phenotype (p = 0.01), high histologic grade (p = 0.05), presence of distant metastasis (p = 0.02), and shorter OS (p =0.01). Conclusion: Blood vessels are mainly located at the peritumoural and peripheral areas in triple negative breast cancers and seem to have a major role in tumour progression by representing means for disease dissemination.