The flowing section explains the context in which our results were generated (refer to the 'Materials and Methods' section for detail on how our quantities are computed). The Normalized Shannon Entropy measure is widely used in ecosystem modelling to quantify species diversity, where it is acknowledge as having great sensitivity to relative abundances of species in an ecosystem [45] . We utilise the same sensitivity to differentiate a samples in cancer datasets. Figure 1 shows that the Normalized Shannon Entropy of prostate cancer tumor samples do not differ much from normal samples. This is in contrast to lymph node metastasis samples that appear to have smaller values of Normalized Shannon Entropy.