[Objective] To study and set up a new newborn screening information system (NSIS) as one of the basic platforms for neonatal screening of inherited metabolic disorders. Methods: The new NSIS-part A: was used to collect the information all of the newborn which collected DBSS(dried blood spots samples), and to deal out the screened results after laboratory test. The new NSIS-part B: to service laboratory and treatment for neonatal screening of inherited metabolic disorders.