To validate the accuracy of the discrimination for the discovered plasma proteome-patterns, we tested the predictive models on the validation cohort groups (Figure 1b) . The best predictive model for each group comparison in the discovery cohort was asked to predict the group class in the validation cohort. We found that the predictive models obtained using the discovery cohort had similar accuracy for discrimination in the different group comparisons for the validation cohort (Figure 1b) . We compared the sensitivity and specificity of the predictive models for both discovery and validation cohort groups in ROC space and found them to be similar ( Figure 2) .