The assumed effectiveness for CCM1 indicates that a corresponding strategy would be very effective in reducing the spread of the epidemic, if R0 is moderate or low and if the number of imported cases does not increase rapidly. In contrast, the household centred measures (CCM2) continue to gain time, even when larger amounts of cases are imported per day. In the model, the effect of CCM1 and CCM2 rapidly decreased for higher Table 2 . Delay (in days) of the peak of the epidemic wave for adults in Germany as a function of the number of imported cases (column A), the number of CCM1 and CCM2 treatments, R0 and the case detection rate (10%, 30% or 50%). values of R0, indicating that this intervention should be stopped when the delay becomes only marginal. To our knowledge, the question of conditions that would lead to stopping interventions (or the lowered effects of specific measures) has so far been studied only in the context of community mitigation strategies and interventions, such as school closures [15] .