Previous electron microscopy studies on DENV infected mosquito cells have shown that virus-induced membrane structures similar to those observed in human cells are prevalent [18] [19] . This extensive requirement in both host and vector, for intracellular membranes that support viral RNA replication and assembly suggest that quantifiable changes may exist in the lipid repertoire of the infected cell to assist in the formation of these membranes. Identifying these lipid changes that occur during infection is a necessary first step to discovering how DENV and its constituent proteins modify the lipid metabolism of cells. The reason(s) for such modifications has yet to be described, but can be pursued with a knowledge of which lipid changes occur. Furthermore, novel therapeutics that modify or inhibit these lipid changes and lipid-protein interactions could conceivably result in inhibition of virus replication.