Results: Parents to 8 of the 25 children had complex psychosocial problems which impaired their ability to support and care for their child during hospitalisation and after discharge. The parent's were characterised by: 1) low level income 2) low level education 3) low level support 4) marginal relationship to the work market 5) physical illness 6) psychiatric illness 7) nonwestern ethnicity and 8) Danish as a second language. Parents of the 8 children had 4 or more of the 8 characteristics, which place them at risk of social exclusion. These parents needed individual interventions such as 1) help to understand the child's HSCT treatment 2) the child's reactions 3) extended emotional support 4) help to facilitate communicate with the welfare system 5) additional economical support and 5) additional help to care for the child. Conclusion: Parents' prior psychosocial situation in conjunction with the strain of caring for a HSCT child exceeds the parent's resources, being the reason why psychosocial interventions are required so the child's health is not placed at an additional risk. Parents of HSCT children at risk of social exclusion experience difficulties with manoeuvring within the welfare-based system, which increases their risk of social exclusion.