While some tabulate the cost differential between highquality draft versus finished sequences to be 3-to 4-fold, and the speed differential to be >10-fold (1), others state that the cost differential is a more modest 1.3-to 1.5-fold (3) . In either case, draft sequencing is cheaper and faster. Experts have debated whether finished sequencing is always necessary, considering the higher costs (1, 3, 4) .