There was no association for gender with antidepressants or sleeping pills among the younger. Among the older, the HR for psychoactive drugs among women was 1.70 (95% CI 1.28-2.27), and it slightly increased after adjustment for physical working conditions. For antidepressant use, the female excess (HR 1.57, 95% CI 1.12-2.22) was slightly increased after adjusting for physical working conditions. The higher HR for the use of sleeping pills among women 2.28 (95% CI 1.50-3.47) was slightly increased after the adjustment for physical working conditions and slightly attenuated by adjustment for familyrelated factors. Discussion: The female excess in the use of psychoactive drugs was larger in the older than in the younger employees. Physical working conditions, psychosocial working conditions and family related factors in general did not explain the differences. On the contrary, adjusting for physical working conditions rather tended to increase the difference. Background: The importance of conducting genetic biobanking research about genetic factors that influence major chronic diseases is critical in disease management. Participants eligible for this line of research may not be aware of genetic biobanking research and reasons to participate. This disconnect between potential eligible participants and the importance of genetic biobank research may hinder progress in disease management. Qualitative studies are needed to identify factors that influence a multi-ethnic sample to participate in genetic biobanking research. Purpose: Project Diversity GATHER (Group discussions Around Themes on HEalthful genetic Research) examines health behaviors and factors that influence women's and men's participation in genetic biobanking research. A multi-ethnic sample was recruited to identify factors influencing research participation. Methodology: 85 women and 50 men from Texas completed an 89-item sociodemographic questionnaire and 60-minute non-ethnically or gendered matched focus group. Wegner's translation process model (1993) was used to indentify intra-and inter-cultural themes that influence participants' participation in research. Participants' characteristics were analyzed through descriptive analyses and qualitative themes categorized on 3 key focus group questions:1) research perceptions, 2) facilitating factors, and 3) barriers to The circadian clock is a self-sustained time-keeping system, which controls rhythmic behavioral, biochemical and physiological processes. Vital functions such as the timing of cell cycles or apoptosis depend on this intrinsic rhythm. In mammals, the cogwheels of this clock are contained in every single cell. These so-called clock genes control their own expression and the expression of clock-controlled genes via several feedback loops. One of these genes is Per1, a clock gene that disposes of a glucocorticoid-responsive element and is therefore most likely influenced by glucocorticoids. In humans, stress is associated with an increase in the glucocorticoid cortisol. Simultaneously, psychosocial stress is seen as a major factor in the etiology of numerous mental health problems. For this reason, we aimed to investigate first, the association of cortisol and hPER1 as well as hPER2, and second, the putative cortisol-mediated influence of acute and chronic psychosocial stress on the gene expression of the same two clock genes in thirty-one healthy men. Our findings suggest that first, cortisol strongly interacts with hPER1 and hPER2, and second, psychosocial stress influences the expression of hPER1 and hPER2. These results implicate a strong clinical relevance of stress on the human circadian rhythm. Most measures of motivation to seek genetic susceptibility testing were developed for the context of predictive genetic testing where mutations confer high risk for disease occurrence. It is unclear whether these measures will capture motives for seeking genetic susceptibility testing where gene variants are associated with small increases in disease risk. In a factorial study examining methods to convey low genetic risk for lung cancer to young smokers, we evaluated a 20-item measure of motives for or against genetic testing in 128 college smokers. Items were adapted from those used in other scales and unique items were generated by a panel of experts to assess the following domains: health behavior motivation/demotivation, altruism, uncertainty reduction, impact on perceived risk and worry, and curiosity about oneself and science. Eight items were correlated significantly with intentions to get tested (p<.05). Exploratory factor analysis of these eight items yielded two correlated factors (r =.22, p <.01): maintaining personal health and curiosity about self and technology. These items formed a reliable scale (alpha=.70) that correlated with testing intentions (r=.63, p<.001). We also asked participants open-ended questions to assess additional reasons for and against testing. Overall, themes paralleled those in our quantitative survey, though participants offered the novel point that they would not want to be tested because the awareness that would come from testing would lead to less enjoyment of life. Prior scales used to assess motivations for testing did not include the construct of curiosity about oneself and technology. This may be unique to intentions to seek new susceptibility tests. Understanding the role of curiosity in test uptake could be informative for this and other novel technologies where health utility has yet to be established. 1 Graduate School of Medicine, University of Tokyo, Tokyo, Japan; 2 Social and Environmental Medicine, Kanazawa Medical University, Uchinada, Japan; 3 Faculty of Healthcare, Tokyo Healthcare Universit, Tokyo, Japan and 4 Ishikawa Health Service Association, Kanazawa, Japan.