B. Infants and neonates with IRRF (regardless of the age) B1. Early IRRF. Neonates from mother with vaginal or urine positive cultures. Respiratory distress signs and CRP > 10 mg/L [52] or PCT > 0.6 ng/mL [53] in the first 72 hours of life; clinical signs of sepsis or blood/BALF positive culture; need for mechanical ventilation.