Based on this paper and meta-analyses of the outcome on Clinical Comprehensive Effect, HAMD scores, SDS scores, HAMA scores, and CGI scores, the prescriptions based on "xiaoyaosan" including pills, powder, decoction dosage form using alone or combined with antidepressants may have beneficial effects on patients with depression. The prescription xiaoyaosan may have the same effectiveness as antidepressants at the end point of the treatment with fewer side effects. The combination group may have significant beneficial effect compared to the antidepressants group variable on onset time with less side adverse events. We tried to analysis the trend of "xiaoyaosan"'s effectiveness by different followup time points as well.