We carried out an overall analysis of plasma proteome pattern overlap by comparing the discovered sets of proteins that discriminate UM, CM, SMA (malaria-positive) and DC (malaria-negative) ill children from the malaria-negative well children CC (Figure 6 , f1 to f6). We show that each plasma fraction (f1 to f6) contains a set of proteins that clearly define both the malariapositive and malaria-negative ill children to those malaria-negative well children in the community. Furthermore, we also show that the set of proteins that discriminate SMA and CM from UM have very little overlap across the six plasma fractions (Figure 6 , f1 to f6).