Objective: Lipomas of the large bowel are rare, they are invariably submucosal and therefore may intussuscept. Infrequently lipomas may also present in the form of multiple polypoid masses in the colon. We present a 69-years old female with 3 submucosal lipomas and a coexisting adenocarcinoma of transverse colon. Method: 69-years old female patient was admitted to hospital because of rectal bleeding for 3 months. Colonoscopic examination revealed mucosaly intact polypoid tumoral masses and an ulcerated tumoral mass in transverse colon. Biopsy of the ulcerated mass was diagnosed as adenocarcinoma. Extended right hemicolectomy was performed. Results: Grossly, ulcerated tumor was 1,5×1×0,4 cm and there were 3 polypoid tumors in cecal area of the right colon which were 2.5-2.0-1.5 cm in their greatest dimensions. Polypoid tumors were yellow, lipomatous on cut surfaces. Microscopically ulcerated tumor was composed of adenocarcinoma morphology and the other polypoid tumors were composed of submucosal mature adipocytes with a thin capsule around them. The diagnosis was colonic adenocarcinoma (pT1N0M0) and submucosal lipomas of colon. The patient had no additional therapy and she is healthy with no evidence of recurrence. Conclusion: This case is presented to remind that there may be multiple lipomas of colon with coexisting malignant epithelial tumors. Objective: Primary liposarcoma of the small intestine is exceedingly rare. To our knowledge, only 7 cases have been reported so far. We report a case of the primary myxoid liposarcoma of the ileum. Method: The patient was 77-year-old woman. CT and MRI revealed a 6-cm-intrapelvic mass, which was proved to be a tumor of the distal part of the ileum, and, therefore, partial ileectomy was performed. Results: The tumor was 6.7×6.3×3.7 cm in size, relatively well circumscribed and located within the intestinal wall without invasion to the neighboring tissues. Microscopically, the tumor had mixture of cellular and myxoid areas, showing proliferation of short spindle and stellate shaped cells in a delicate capillary vasculature. Univacuolated tumor cells and a small number of lipoblast-like cells were also seen. Immunohistochemically, these proliferating cells were positive for S-100 protein. According to these pathological findings, we diagnosed the tumor as myxoid liposarcoma. FISH methods showed the tumor had chromosomal translocation t(12;16)(q13;p11). Conclusion: The differential diagnosis of this includes other spindle cell tumors such as GIST and myogenic tumors. But we could arrive at the proper pathological diansosis following the above morphological features and the specific chromosomal translocation. We will also discuss the clinico-pathological features of the cases including ours.