The most recent MIDAS study examined the effectiveness of a set of proposed targeted, layered containment strategies that combined a number of transmission interventions currently available to public health planners in the United States [9] . These include nonpharmaceutical social distancing measures and antiviral treatment and prophylaxis. All three MIDAS models examined the same set of interventions, although each of the three implemented the interventions using different approaches. The three sets of models also examined the sensitivity of the effectiveness of the intervention combinations to thresholds for triggering the interventions, levels of case ascertainment and compliance, and the transmissibility of the circulating pandemic strain. The intervention scenarios examined reflect those being considered now by the United States Homeland Security Council and Department of Health and Human Services (DHHS).