Differentially expressed serum proteins in FM were subjected to functional pathway analysis using IPAversion 9.0 (IngenuityH Systems, www.ingenuity.com) to determine association of the identified proteins with various physiological pathways. The significance of association between our dataset and identified networks/pathways was considered on basis of two parameters, ratio and p-values. Differentially expressed proteins in FM patients were also analyzed using PANTHER system; version 7 (http:// www. pantherdb.org) [41] and DAVID database version 6.7 (http://david.abcc.ncifcrf.gov/home.jsp) [42, 43] . The list of Uni-Prot Accession from each dataset was uploaded in tab delimited text format at once, which was mapped against the reference Homo sapiens dataset to extract and summarize functional annotations associated with individual or group of genes and proteins.