In recent years, host cell-directed antivirals have experienced growing recognition as a new concept for the development of advanced generation antivirals with the potential to counteract the challenge of preexisting or rapidly emerging viral resistance [14, 15] . Novel automated genomics and proteomics analyses have greatly advanced our insight into host-pathogen interactions [37, 38, 39, 40, 41, 42, 43, 44] . These studies have underscored the notion that several cellular pathways are exploited for virus replication [45, 46] , supporting the hypothesis that a host-directed antiviral may enjoy an expanded viral target range, rendering it effective for the treatment of several related viral diseases.