Amongst the phospholipids, several phosphatidylinositol species were up regulated 3-4 fold in the untreated DENV infected cells compared to the C75 treated cells ( Figure 7B ). However, none of these PI species were phosphorylated. A single species of PG was also up regulated by over 5 fold in the untreated cells. Since C75 disrupts the formation of lipids down stream of FAS, several fatty acids (stearic and palmitic acid) were down regulated in the drug treated cells. An enrichment of these fatty acids was observed in the untreated cells upon comparison with C75 treated cells ( Figure 7C ). In contrast, as observed in the previous comparison of DENV infected cells to uninfected cells ( Figure 5 ), oleic acid was down-regulated in untreated DENV infected cells and therefore, showed enrichment in C75 treated cells. Interestingly, C75 treated cells also showed a down regulation of metabolic intermediates such as mono-and diacylglycerol as well as phosphatidic acid. Enrichment of these lipids was observed in untreated DENV infected cells compared to C75 treated cells ( Figure 7D ). In addition to the phospholipids, de novo synthesis of sphingolipids was also disrupted by C75. Key intermediates in this pathway such as N-palmitoylesphingosine and N-stearoylesphingosine were down regulated upon treatment of cells with C75 and up regulated in untreated DENV infected cells ( Figure 7A and Table S3 ).