2. In the calculation of I =Σn 6 for viruses (which is also I 1 for all the higher organisms discussed), where Σn is the summation of the lengths of all protein sequences, the authors make the following note: I is the same as the size of the protein coding area in the DNA sequence. It would be helpful if this equality may be explained. This paragraph, as many others, suffers from simplistic explanation of biological phenomena. In p.4: \...there are no regulations of quantity of gene products. Viruses only need to produce their proteins one by one in order." -this is not true, most if not all viruses have elaborate mechanisms of, e.g., separating the expression of early and late proteins; of maintaining quite precise ratios of different protein products expressed simultaneously; etc. Many of these processes require action of virus-encoded signals and cellular proteins. But is this relevant for computing complexity? in p. 5:\In fact, mutations are not normally allowed for a real protein sequence" -not true, viruses are notorious for rapid evolution that is facilitated, in the case of RNA viruses, by a particularly high mutation rate (but again, is this information even needed for what authors are proposing?). Why does the quantity I hold for cases of overlapping genes? A simple example that exemplifies both the above facts would be beneficial for the readers.