Dr. Keefe will summarize the current state of science on pain coping in osteoarthritis patients. He will discuss the theoretical background of pain coping and then continue to critically review the research and intervention studies in this area. Dr. Crombez will review research on hypervigilance and attentional bias in chronic pain. He will discuss implications for the understanding of chronic pain and for future research. Dr. Steultjens will summarize current literature showing that psychological distress is a major predictor of poor outcome of multidiciplinary rehabilitation in chronic pain and fibromyalgia. He will discuss theoretical interpretations and practical implications of these findings. Dr. Denison will focus on recent treatment approaches aiming at improvement of function and reduction of distress in patients with musculoskeletal pain. Treatment builds on basic motor and behavior learning principles and cognitive-behavioral principles. This presentation provides an overview and update on the literature on pain coping in osteoarthritis patients. The presentation is divided into four sections. In the first section, the conceptual background for studies of pain coping in osteoarthritis is reviewed. In the second section, recent studies of pain coping are critically reviewed including studies on the role of pain catastrophizing, pain communication in osteoarthritis, pain coping in morbidly obese osteoarthritis patients, and brain correlates of pain coping. In the third section, interventions designed to enhance pain coping are highlighted, including studies of partner-assisted coping skills training, communication skills training, and combined pain coping skills training/lifestyle behavioral weight management. In the final section, the strengths and limitations of current research are summarized and important directions for future research described. Chronic widespread pain (CWP) and fibromyalgia (FM) are common syndromes characterized by widespread musculoskeletal pain with no obvious underlying pathology. Although multidisciplinary rehabilitation treatment has been shown to be effective in CWP and FM, on average effect sizes are small. One possible area of improvement is referring those patients for treatment in whom a clinically relevant treatment effect can be expected. To be able to do this, patient characteristics associated with treatment success need to be identified. This presentation will first provide results from a systematic review of current literature on predictors of improvement following multidisciplinary rehabilitation treatment. Four outcome domains were studied: pain, physical functioning, emotional functioning, and general improvement / quality of life. In general, the available evidence suggests that cognitive and emotional factors are predictive of treatment outcome. For both pain and physical functioning, poor treatment outcome was predicted by the presence of emotional problems, interpersonal distress, and depression. Apart from these cognitive and emotional factors, evidence for baseline pain intensity and impact of pain as predictors of treatment outcome were found. Additionally, data will be presented from a prospective cohort study on health outcomes in CWP and FM, for which analyses are currently in progress. Based on the findings from the systematic review and prospective cohort study, pathways for successful rehabilitation treatment in CWP and FM will be discussed. A majority of patients with musculoskeletal pain (MSP) are managed within primary health care (PHC). While physicians are involved in the initial assessment of patients' problems, physical therapists typically carry out interventions to reduce pain and improve function.