Comparison of the entorhinal cortex with non-epileptic lateral temporal lobe revealed 16 regulated genes of which 10 were upregulated and six were downregulated. This study suggested dysregulation of the neurotransmission and complement systems within the entorhinal cortex as another pathway affected in the process of epileptogenesis (46) . On the other hand, the study by Özbas-GerÇeker et al revealed 143 differentially expressed genes that matched functionally to genes associated with basic metabolism, transcription regulation, protein synthesis and degradation, signal transduction, structural proteins, regeneration and synaptic plasticity and genes of unknown identity or function (74) .