Our results shed light on the natural history of SHFV. Asymptomatic infections of captive patas monkeys, vervet monkeys, and baboons support the notion that African primates are the natural hosts of SHFV [2, 3] . However, SHFV has, to our knowledge, only been isolated from these species upon their arrival in primate colonies, raising the possibility of infection during transport. The two new SHFV variants that we have discovered were isolated from a wild Ugandan red colobus monkey in a natural setting, providing conclusive evidence that wild African primates are natural hosts of SHFV.