Our data demonstrate that myriad opportunities exist for key zoonotic pathogens to be imported into the United States or, if already present, to be introduced in a new context (e.g., in an animal sold as a pet). Imported animals of a large number of taxa were found to be capable of carrying risk zoonoses; these diseases include such serious public health threats as rabies, the fi lovirus hemorrhagic fevers, tuberculosis, and highly pathogenic avian infl uenza.