In conclusion, although the PCA approach is not intended to improve all aspects of virtual screening, such as generating more accurate binding poses, it extends conventional consensus scoring in a quantitative statistical manner, therefore, it has great potential for use in the virtual screening process. Future experiments are needed to further analyze the performance of PCA for other receptor binding sites. We believe that the two low-micromolar inhibitors described here may represent a starting point for finding potent and selective molecules capable of preventing BACE-1 activity for the treatment of Alzheimer's disease.  2,500-year Evolution of the Term Epidemic The term epidemic (from the Greek epi [on] plus demos [people]), first used by Homer, took its medical meaning when Hippocrates used it as the title of one of his famous treatises. At that time, epidemic was the name given to a collection of clinical syndromes, such as coughs or diarrheas, occurring and propagating in a given period at a given location. Over centuries, the form and meaning of the term have changed. Successive epidemics of plague in the Middle Ages contributed to the definition of an epidemic as the propagation of a single, well-defined disease. The meaning of the term continued to evolve in the 19th-century era of microbiology. Its most recent semantic evolution dates from the last quarter of the 20th century, and this evolution is likely to continue in the future. A t the start of the 21st century, epidemics of infectious diseases continue to be a threat to humanity. Severe acute respiratory syndrome, avian influenza, and HIV/AIDS have, in recent years, supported the reality of this threat. Civil wars and natural catastrophes are sometimes followed by epidemics. Climate change, tourism, the concentration of populations in refugee camps, the emergence of new human pathogens, and ecologic changes, which often accompany economic development, contribute to the emergence of infectious diseases and epidemics (1) . Epidemics, however, have occurred throughout human history and have influenced that history. The term epidemic is ≈2,500 years old, but where does it come from?