The purpose of this study was to explore seasonal distribution of active SLE. Our hospital is the largest hospital in the local area (Zhanjiang City, Guangdong Province, China) and is also the control center for rheumatic autoimmune disease. The majority of patients with SLE in Zhanjiang City attend the hospital for diagnosis and treatment. Patients with active SLE in this study reside in Zhanjiang City. According to the SLEDAI score system, SLEDAI ,5 was considered as mild SLE, 5-10 as moderate and .10 as severe. 13 Hormones and immunosuppressive agents are generally given when the SLEDAI is $6. 14 After administration of hormones and immunosuppressive agents, most patients still have moderate SLE (SLEDAI: 5-10) for a lengthy period. Although therapy is effective, SLEDAI fails to decrease to 0. To ensure patients had active SLE, only patients with a SLEDAI of $10 were included in this study. These patients, therefore, basically reflect the distribution of active SLE in Zhanjiang City.