Several components of the innate immune response have been shown to impact on the resistance of adult mice and to restrict efficiently CHIKV infection and its consequences in vivo [10] . We decided to investigate the importance of GADD34 upon intradermal injections of CHIKV to WT (FVB) and GADD34 DC/DC mice. Neither strain of adult mice was affected by intradermal injections of CHIKV, with little statistically significant differences in the virus titers found in the different organs. Thus, GADD34 deficiency does not annihilate all the sources of type-I IFN in the infected adult animals, a situation exemplified by the capacity of GADD34 DC/DC bone-marrow derived dendritic cells to produce reduced, but measurable IFN-b in response to poly I:C [60] . This also infers that the light impact of GADD34 inactivation on mouse development [61] does not render these animals more sensitive to CHIKV infection.