A number of mostly immune-mediated diseases are commonly observed in patients with PBC. Thyroid dysfunction is frequently associated with PBC, often predating its diagnosis [80] . Sicca syndrome is seen in up to 70% of patients [81] . Incomplete or complete CREST syndrome (calcinosis cutis, Raynaud syndrome, esophageal motility disorder, sclerodactyly, teleangiectasia) is not uncommon [82] . Celiac disease has been reported in up to 6% of patients [72] and is by far more commonly associated with PBC than inflammatory bowel diseases [83] .