Conclusion: Our study, for the first time reports the presence of anti-SV1 immunoreactivity in tumors of the salivary glands. Furthermore, the high association of SV1 expression with the malignant as opposed to the benign neoplasms implies a role of SV1 in the progression of the disease. A surprising finding of our study was the high positivity for SV1 exhibited by the Warthin tumors that implies biological similarities between these histopathological entities of the salivary glands. These results imply that the use of antagonistic analogs of GHRH merit further investigation. Objective: Sialadenoma papilliferum (SP) is a rare, benign neoplasm of salivary gland origin which manifests as an exophytic papillary excrescence of the mucosa. Indeed, SP is both an exophytic proliferation of papillary stratified squamous epithelium above the mucosal surface and an endophytic salivary ductal proliferation beneath the mucosa. It arises predominantly in minor salivary glands and usually affects patients in the age range of 32-87 years, with reports in young patients being exceedingly rare. Method: We report a case of a previously healthy 20 yearold man diagnosed with a nodular mass in the upper lip buccal mucosa. The tumour was excised and submitted for microscopic examination.