Given the diminished early cytokine responses and enhanced liver disease observed in 3d mice, the contribution of endosomal TLR responses to control of virus replication in the liver was assessed in WT and 3d mice infected with MCMV. Compared with those in WT mice, viral titers were elevated by 1 log on day 3 of infection in 3d mice, and remained significantly higher at day 5 post-infection when compared to WT (Fig. 6) . Ultimately, while WT livers showed evidence of viral clearance at days 7 and 9 postinfection, 3d liver virus titers remained approximately 2 logs higher at these times of infection as compared to WT mice. Thus, endosomal TLR signaling contributes to the control of MCMV replication in the liver during acute infection.