Marburg virus, complete genome), as the WGASA reference genome, and then used random sub-samples from the four draft genomes. Marburg was the only organism for which we could obtain a sufficient number of draft genomes for the SAP Monte Carlo simulations. A total of 814 simulations for DNA signatures, i.e. individual runs of the DNA signature pipeline, and 48 simulations for protein signatures were performed using Marburg finished and draft data, requiring an average of 15 min per simulation.