Analysis of the overall fold change in PE at the 36 hr time point ( Figure 3A ) does not show a difference between the virus-exposed (DENV and UV-DENV) cells and the mock. This is due to an equal number of individual lipid molecular species being up regulated as were down regulated ( Figure 3D ). At the 60 hr time point the relative levels of PE in virus exposed cells were lower than mock levels ( Figure 3B and D). There was also limited overlap between the specific PE molecular species regulated between DENV-and UV-DENV-exposed cells (Table S1 ). Given that insect cells have a high abundance of PE in their membranes (40-50%), it is interesting that there is a selective requirement for PC (over PE) in DENV-infected mosquito cells [22] .