Extended phylogenetic profiles for each category (metabolic pathways, GO terms, GO Slim terms and PFAM categories) were obtained from SYNERGY output by summing the phylogenetic profiles from their component orthogroups. We define a category-level phylogenetic profile as the sum of its component orthogrouplevel phylogenetic profiles. The evolution of each of these categories can be quickly visualized on our website. Since genes with the same phylogenetic profile can be linked functionally [94] , the webpage for each category contains a link to other categories with similar phylogenetic profiles (Methods). Categories with the most similar profiles were obtained by calculating Euclidean distances to all other profiles.