After outlining the structure of the problem and the discretization parameters typically required for a size-andshape analysis of SV data, it is possible to discuss the computational requirements. Demeler's 2DSA method was implemented with the goal of accessing a high-performance computing environment (TeraGrid) in order to avoid prohibitive memory limitations that Demeler and colleagues perceive to occur when using ubiquitous ordinary laboratory workstations. Specifically, the authors (Brookes et al. 2009 ) estimate the memory needs for modeling a set of M = 50-100 sedimentation velocity scans with typically N = 500-800 data points each by only a low-resolution 10 9 10 (S 9 F) grid. They conclude that ''Performing just a 10 9 10 grid search on such an array would require close to half a gigabyte of memory just for data storage of a single experiment.' ' (Brookes et al. 2009 ). We will examine this estimate in more detail.