If no any single experimentally derived peptide is related to any region on the antigen, it only indicates that this method is not applicable for the case through the mapping. However, it does not mean that no interacting epitope exists on the antigen, which may be detected by other methods. In this regard, the likelihood of finding a genuine epitopic region on an antigen should be higher if more associated peptides can be detected through the mapping. Furthermore, if more mapping methods can be combined together for exploring as many associated peptides as possible through the mapping, the likelihood of finding a genuine epitopic region on the antigen should be enhanced. On the other hand, users of a mapping tool would prefer to know some sort of certainty about the candidate epitope determined by the associated peptides through the mapping in relation to the likelihood of being a genuine epitope. In other words, some kind of verification on the candidate epitope, if not a confirmation, will be much helpful for the users to make an initial assessment on the quality of the candidate. A single method cannot achieve this goal by self verification, but a combined approach of two or more independent methods would be able to provide mutual verification on the candidate of the same case. Web tools realizing such collaborative concept have not been tried so far.