MimoPro [16] has brought improvement on processing speed and sensitivity over both PepSurf and Pep-3D-Search. It uses an adaptable distance threshold (ADT) regulated by an appropriate compactness factor to define a graph from a small patch on the surface of a protein. Such a regulated graph contains a certain number of edges, which can guarantee that searching through the graph is more efficient. On average, MimoPro achieved the best performance among the three, but individual cases produced mixed outcomes. This indicates that no one dominates over others in all circumstances but each has its advantage in dealing with particular cases.