Objective: Investigation of the MUC gene in pancreatic ductal adenocarcinomas (PDA). Method: In the present study, we examined the expression of MUC1, 2 and 5 AC types by immunohistochemical analyses in PDA from 74 patients. Overall survival curves were drawn by the Kaplan-Meier method. For all analyses, p<0.05 was considered to be statistically significant. Results: In our cases most of the PDA was presented as MUC1+/MUC5AC + phenotype -42 % cases (31/74). The group with intestinal phenotype mucin, which characterized by positive expression of MUC2 and CDX2, was only 7 % (5/74). The group which characterized by positive expression only MUC5AC (gastric phenotype), was 15 % (11/74). The survival rate of patient better in group with MUC2 expression. Cumulative survival at 12 months after surgery was 1.0 and the median postoperative follow-up period was 17 months. The most aggressive behavior was PDA with expression only MUC1 ("true pancreatobilliary type"). Cumulative survival at 12 months after surgery was 0.25 and the median postoperative follow-up period was 7 months. Conclusion: The mucin profile as a prognostic factor is important not only for intraductal pancreatic mucinous neoplasm, but and for ductal pancreatic adenocarcinoma.