We have reported here the clinical manifestations in 37 patients with combined FV and FVIII deficiency from India. This is the largest series in the world describing the clinical manifestations of patients with combined factor V and VIII deficiency reported so far. It is evident from this as well as previous studies [7, [9] [10] [11] that the bleeding symptoms in combined FV and FVIII deficiency is almost similar to the deficiency of single coagulation factor. There is no clear evidence to support increased bleeding manifestations due to the combined deficiency of two coagulation factors.