Microparticles (MPs) are small plasma membrane vesicles that are less than 1 μm released by several cell types (macrophages, platelets, endothelial cells, granulocytes, monocytes, lymphocytes) following chemical (cytokines, thrombin and endotoxin), physical (shear stress and hypoxia) [17] and apoptotic [18] stimuli. One of the first described roles for MPs was in the initiation and amplification of the coagulation cascade and furthermore they play a pivotal role in thrombosis, in the propagation of inflammation, modulation of vascular tone, angiogenesis, stem cell engraftment, and tumour metastasis. These MPs' effects depend on molecules harboured at their surface or within their cytoplasm due to their origin cell [18] . MPs are normally present in blood from healthy individuals but they increase in patients under pathological states associated with inflammation, such as sepsis [19] , preeclampsia [20] , metabolic syndrome [21] , pulmonary arterial hypertension [22] , and malaria [23] , strengthening the notion that MPs may play a role in these diseases. The phenotype of circulating MPs is also different in different pathological states, and detection of its cellular origin may serve as a predictor or marker of the diseases [24] .