Several proteins with mitochondrial, lysosomal and ER annotations were upregulated in the cytoplasmic fraction already at 6 h post-infection indicating rapid changes in these compartments upon infection (Fig. 1D ). Based on clustering analysis, these proteins belong to a group where the amount of protein in the cytoplasmic fraction increases rapidly at 6 h post-infection and starts to decrease at later time points after infection (Fig. 3C) . Surprisingly, the mitochondrial proteins in this group contain several components of the inner mitochondrial membrane including components of the electron transport chain and oxidative phosphorylation. Lysosomal proteins belonging to this cluster contain for example lysosomal proteases, cathepsins (Fig. 3C ).