Objective: Angiogenesis is essential for tumoral growth and progression. The ameloblastoma is a benign but locallyinvasive odontogenic neoplasm with distinct behavioural characteristics of its subsets. Whether angiogenesis contributes to a more aggressive course in these variants remains unclear. The aim here was to determine and compare the tumoral microvasculature in different ameloblastoma subtypes and to speculate on their significance. Method: Immunohistochemical staining for 4 vascular markers (CD31, CD34, CD105 and VEGF) was performed on archival tissues of 40 cases solid/multicystic (SMA), 20 unicystic (UA), 3 desmoplastic (DA) and 14 recurrent ameloblastoma (RA). Mean microvessel density (MVD) at the tumour advancing front and centres were obtained. Results: VEGF was heterogeneously expressed in the tumoral epithelium in all ameloblastoma subtypes. Protein localization was membranous/cytoplasmic. Mean MVD was slightly higher in SMA compared to UA but the difference was not significant (P>0.05). Mean MVDs were not significantly different between primary and recurrent ameloblastoma; and between tumoral centre and advancing front of each subtype (P>0.05). Conclusion: Although ameloblastoma subtypes are distinctive in their clinicopathologic presentations and behaviour, their tumoral microvasculature is not different. This suggests that angiogenesis is not a major factor influencing the progression of these ameloblastoma subsets.