The advent of 2009 pandemic S-OIV has largely depleted the number of seasonal H3N2 and H1N1 infections, most likely via cross-reactivity between novel and seasonal strains [22] . Consequently, the conclusions of this paper may not necessarily apply to current dynamics of seasonal H3N2 and H1N1. However, the fact that H1N1 shares a tropic-centric movement pattern with H3N2 despite cross-reactivity suggests that these patterns may still persist even in the presence of the cross-reactive S-OIV. Moreover, this paper demonstrates that when more sequence data is deposited in NCBI, a similar methodology can be applied to predict global circulation of S-OIV as well.