We have developed a web-based prototype of the cKASS system that allows individual users or collaborative communities to access the service anytime and anywhere, without a complex technical configuration process (Fig. 1) . Two types of databases are used to support cKASS. First, a relational database is used to store user information and KB descriptors(e.g., KB domain and status). Second, KBs are stored as RDF triples using triple store and queried using SPARQL, an RDF query language, with the Jena SDB (SPARQL database,) providing robust and scalable storage. Existing resources stored in standard RDF and OWL formats can be easily loaded into the triple store and used as a basis for constructing new syndrome definitions.