The RSV G protein is one of the major protective antigens and good inducer of strong serum and mucosal neutralizing antibody responses. It also has single immunodominant I-E d epitope spanning RSV G amino acid 183 to 198 and largely induces a specific subset of CD4 T cells (7, 8) . Previously, we have reported that RSV G protein fragment (spanning amino acid residues 131-230) delivered by recombinant adenoviral vector successfully elicited long-term protective immunity against RSV infection in mice (9) .