Objective: It has been established that Macrophages (MF) play a basic role in the tumor microenvironment. Still, the definition of the function of MF with relation to tumors is still vague, mainly when MF are observed acting occasionally as pro tumor and elsewhere as anti tumor. Method: In this paper we attempt to sum up the accumulating observations of MF function with respect to the microenvironment and the tumor entity. Results: Through the different stages of tumorigenesis and growth, macrophages are engaged in various signaling cascades that tame them to perform a certain function in a given microenvironment. This makes MF a multi-program cell with unique adaptivity. We assume that without the macrophages tumors cannot progress. Conclusion: The available MF subtype analysis is still inadequate and doesn't bear into account the dynamics of tumorigenesis and growth. Our presented MF schemes provide an insight on the tumor microenvironment with respect to stage. A complex view on the signaling cascades affecting MF is needed to formulate a novel classification of MF based on their programming. This consequently can be the basis of the development of "anti-MF therapy" or on a larger scale "anti-tumor microenvironment therapy". OFP-14-009 Lodox X-ray is an invaluable asset in autopsy procedures L. Liebenberg * * University of Cape Town, Dept. of Forensic Medicine, South Africa