Objective: It is now well established that patients with inflammatory bowel disease presented a higher risk to develop a colon cancer. Our previous works characterized the link that exists between bacterial infection and inflammation and highlighted the role of the microenvironment on the onset of chronic inflammation. Here, we wished to understand the role of inflammasome, a complex of proteins that is activated by microbial motifs and the purinergic receptor P2X7 and involved in the maturation of IL-1β. Method: We treated P2X7R knockout mice to induce acute colitis (3 % DSS) or colitis associated colon cancer (AOM and DSS). Results: We showed that P2X7R KO mice are more resistant than wild type mice to a DSS-induced colitis. Further, we demonstrated that P2X7R KO mice are highly susceptible to inflammation driven colon tumorigenesis. In addition, we showed that tumors from P2X7R KO contained more neutrophils (CD11b+/Ly6G + cells) and less macrophage (CD11b+/Ly6G-) than tumors obtained from WT mice. Conclusion: We will present results on the characterization of the pro tumoral tumor associated neutrophils and the molecular mechanisms that are linked to the presence of such immune cells.