As shown in Figure 6A , CER levels in C6/36 cells showed clear elevation in DENV-infected cells compared to mock-infected or UV-DENV exposed cells. Comparison of the different subcellular fractions indicated that the elevated CER was primarily concentrated in the CE fraction with the exception of two species (d18:1/ 16:0 and d18:0/16:0) which were enriched in the 16K pellet. These two species consist of the most abundant fatty acids observed in cells. The analysis of SM levels in mosquito cells ( Figure 6B ) indicated that virus exposed cells have a higher level of SM compared to mock-infected cells. This is most evident in the 16K pellet with the exception of the most abundant species (d18:1/20:0) that showed the highest levels in the CE. Comparison of infectious DENV to UV-DENV exposed cells indicates that the latter which is incapable of replication maintained higher levels of SM overall.