Results: Of the 65 CR confirmed amyloid positive biopsies, 61 showed green birefringence with HE. Of the 65 CR confirmed amyloid negative biopsies, two were considered as false positive. The sensitivity, specificity, positive and negative predictive values were estimated as 94 %, 97 %, 97 % and 94 %, respectively. Conclusion: We concluded digitally polarized HE sections can be used as a fast and first step diagnostic method for renal amyloidosis.