Egr-1 is a transcription factor that is also known as zif268, Krox-24, NGFI-A, and TIS8 [7] . It is induced by several external stimuli including growth factors, different forms of stress, and hormones. As a result of stimulation from various factors, egr-1 gene products advance to play a role in several cellular functions such as, but not limited to, growth, proliferation, and differentiation [8] . Egr-1 is part of a zinc-finger gene family that includes Egr-2, Egr-3, Egr-4, and the Wilms tumor suppressor (WT1) [9] . TPA is used to activate a lytic infection in KSHV-infected cells [10] . Egr-1 mediates the effect of TPA activation and is a downstream target of MAPK signaling [9, 11] . Furthermore, MAPK signaling is crucial for triggering KSHV reactivation from latency [12, 13] . However, despite the ability of Egr-1 and KSHV ORF50 to interact with each other, there is little information available describing this association.