Cytokines are proteins secreted during innate and adaptive immunological responses, acting as inflammatory mediators or modulatory molecules during several haemorrhagic fevers [7] . Clinical studies support a key role for cytokines in the DHF pathogenesis [8] [9] [10] [11] [12] [13] . During Dengue virus infections, cytokines are involved in the disease onset and homeostatic regulation. Specifically, TNF-α, IL-1β and IL-6 have been associated with both coagulation (F1+2 and TATc) and fibrinolysis (t-PA, PAPc, and D-dimmer) activation markers [14] . This activation is more striking in patients with severe clinical manifestations, although it can be found at lower degrees in patients with mild disease [15, 16] .