As of today, renalase is the only enzyme known to be secreted into blood that can degrade circulating catecholamine and may have a great value in prevention of kidney diseases and cardiovascular diseases. Discovery of renalase has drawn the attention of the scientific world [22] [23] [24] . Even though there have been some debates (Boomsma F), much importance is given to its significance as further studies are carried out [25] . It may have a great value in further understanding increased sympathetic activity and mechanism of cardiovascular complications in CKD patients as well as a prevention of CKD and cardiovascular diseases [26] [27] [28] . Both in vitro and animal studies have demonstrated the possible effects of renalase in chronic renal failure and cardiovascular diseases [29] . It can be speculated that replacement or supplementation of renalase may bring up a promising treatment.