Method: Thirty cases of laryngeal squamous cell carcinomas (LSCCs) (gradeI: 11, gradeII: 8, gradeIII: 11) and one large cell neuroendocrine carcinoma (NEC) were studied using double staining immunohistochemical method for E-Cadherin (mAb-DAB) and SNAIL + SLUG (pAb-AP). The colocalization of both molecules was assessed and the expression was compared to the adjacent normal or dysplastic epithelium and the histological grade. Results: Normal squamous and dysplastic epithelium show strong nuclear Snail expression and complete E-Cadherin membranous positivity. Reduction/loss of Snail with or without E-Cadherin membranous expression is observed in 14/30 (47 %) LSCCs with a tendency for inverse relationship with E-Cadherin at the invasive front. 16/30 (53 %) LSCCs strongly express nuclear SNAIL, without absolute relationship to the reduction/loss of E-Cadherin, with a tendency for SNAIL negativity in grade II (75 %). The NEC is nuclear SNAIL negative but cytoplasmic positive. Conclusion: SNAIL and E-Cadherin may be retained, reduced or lost in LSCCs, without a definite inverse relationship. These immunophenotypic combinations need further investigation.