The drug (rFVIIa) promotes local formation of thrombin when it combines with tissue factor exposed at the level of the endothelium. It was initially indicated to treat coagulopathies in patients suffering from haemophilia, although its use has extended to other haematological conditions. Beyond these indications, it is administrated on a more compassionate level. The requirements for its effective use in controlling serious haemorrhages are fibrinogen and platelet readings of over a 50 mg/dl and with 50.000/μl respectively, in addition to a pH > 7.20.