Moreover, only little research has been done to examine the pathway through which SI affects health. Therefore we analysed the mediating effect of effort-reward imbalance at work (ERI) on this association. Methods: Analyses were based on a random sample of 1111 male employees (25-64 years) from the south-west of Germany. Data were collected by a telephone interview in 2008/09. Information on socio-demographic variables, social status indicators (education, occupational grade and income), occupational strain (ERI), and physical as well as mental health (SF-12) were given. Results: SI was significantly associated to low mental health, both directly and, consistent to our hypothesis, indirectly via low rewards. As SI was also related to low effort, no association was found for the quotient of both scales (ERI) and mental health. The effect of SI on physical health was entirely mediated by low rewards without any direct effect. The inclusion CITATION ABSTRACT 10:48 AM-11:06 AM OS08-B WORKPLACE BULLYING AND MENTAL PROBLEMS Eero Lahelma, PhD, Tea Lallukka, PhD, Mikko Laaksonen, PhD, Ossi Rahkonen, PhD and Peppiina Saastamoinen, MSc Department of Public Health, University of Helsinki, Helsinki, Finland. Background Bullying is a common problem at workplaces with potentially long-lasting adverse consequences for the mental health of the bullied victims. We studied whether workplace bullying is prospectively associated with mental problems as indicated by antidepressant use among middleaged women and men. Methods The participants were municipal employees aged 40-60 from the Finnish Helsinki Health Study cohort baseline survey in 2000-02 (n=8960, response rate 67%). Workplace bullying was divided into those who reported being currently bullied and those who reported having been previously bullied. Data on antidepressant prescriptions from the Finnish Social Security Institute registers were available before the baseline survey and were followed up until the end of 2007. The prescription data were individually linked to the baseline survey data for those consenting for such linkage (78%). Hazard ratios (HR) adjusted for age were calculated using Poisson regression analysis, excluding those with antidepressant use 1.5 years prior to the baseline survey. Results At baseline 5% of both women and men reported being currently bullied, and 19% of women and 13% of men reported having previously been bullied. Compared to the never bullied (HR 1.00) the currently bullied were more likely use antidepressants during the follow up among women (HR 1.55, 95% CI 1.09-2.22) as well as men (HR 2.57, 95% CI 1.46-4.52). The previously bullied were also more likely to use antidepressants but somewhat less so among men. Conclusions Victims of workplace bullying are disproportionately prescribed antidepressants, suggesting that they run the risk of developing mental problems as a consequence of bullying. Workplace bullying is an occupational and public health issue of concern which should be tackled in order to safeguard employee mental health and well-being. of further risk factors (age, BMI) did not attenuate these results. Conclusions: SI is significantly associated to ill health. Moreover, results indicate that at least a part of this relationship is explained by low rewards at work, findings with implications for further research in job strain and health inequality. Background: Return to work (RTW) in acutely hand-injured patients is not only influenced by biomedical determinants, but work-related and psychosocial determinants may influence RTW as well. Aim of this study was to investigate which factors determine RTW. Methods: Patients with acute hand injuries (n=69) answered several questionnaires on biomedical, work-related and psychosocial factors. All patients were between 18 and 65 years, employed, had sustained an acute hand injury and were treated in one of the two participating rehabilitation centers. Results: Primary outcome measure was RTW, dichotomized into early (≤10 weeks) and late RTW (>10 weeks). The majority of the patients (55%) returned to work in the late stage. Six percent of the patients did not RTW within one year, and 4% failed to RTW. Accident location (Chi2:10.101; p=.001), job independence (U= 372.000; p =.021) and symptoms of Post-Traumatic Stress Disorder (S-PTSD) (U=257.000; p= .001) were univariately associated with RTW, and were entered in the logistic regression analysis. Both S-PTSD (having more symptoms) and accident location (accident sustained on the job) were found to statistically predict late RTW in hand-injured patients. Exploration of S-PTSD: As S-PTSD are predictors of RTW in patients with acute hand-injuries, it is relevant to investigate which patients develop S-PTSD, and which patients do not. Therefore, we investigated which factors predict S-PTSD in this population. Pain (r = .530; p < .001), satisfaction with hand function (r=.−.451; p<.001), aesthetics (r=−.320; p=.009), palliative coping style (r=.281; p=.022) and avoidant coping style (r=.283; p=.022) were univariately associated to S-PTSD. By performing a linear regression analysis, pain and aesthetics of the hand were found to statistically predict S-PTSD (adjusted R2: 33.9%). Conclusion: When patients sustained their hand injury on the job, attention should be paid to RTW during rehabilitation. Furthermore, patients should regularly be checked for S-PTSD, especially if the aesthetics of the hand are severely disturbed, or when patients experience pain. Most working adults with low back pain (LBP) continue to work despite pain, but few studies have assessed self-management strategies in this at-work population. The purpose of this study was to identify workplace challenges and self-management strategies reported by workers remaining at work despite recurrent or persistent LBP, to be used as a framework for the development of a workplace group intervention to prevent back disability. Workers with LBP (n=38) participated in 5 focus groups, and audio recordings of sessions were analyzed to assemble lists of common problems and coping strategies. A separate analysis provided a general categorization of major themes. Workplace pain problems fell within 4 domains: activity interference; negative self-perceptions; interpersonal challenges; and inflexibility of work. Self-management strategies consisted of: modifying work activities and routines; reducing pain symptoms; using cognitive strategies; and communicating pain effectively. Theme extraction identified 6 overarching themes: knowing your work setting; talking about pain; being prepared for a bad day; thoughts and emotions; keeping moving; and finding leeway. To retain workers with LBP, this qualitative investigation suggests future intervention efforts should focus on worker communication and cognitions related to pain, pacing of work, and employer efforts to provide leeway for altered job routines. The development of newborn screening is benefitted by technological advances enabling blood spot testing to identify a wider variety of conditions (Stewart 2006) . Introduction of these advances through programmes of research delivered in parallel to routine screening requires consideration of the ethical issues involved and appropriate mechanisms for gaining parental consent (Pollitt et al. 1997 , Chadwick et al. 1998 ). Ponder et al. (2008 argue that ethical review needs to be more flexible in its attitude to the provision of information and consent processes for some types of research. Exploration of parental views on consent practices is needed to inform the debate, and specifically consider whether more flexible research protocols are needed to fit with the public perception of research in this context. This study has been undertaken to explore the views of parents and future parents regarding information provision and consent processes for expanded newborn screening in the UK. Focus groups (n=29) and a web-survey (n=142) were employed to capture parental experiences of routine screening, and perceptions and attitudes to an expanded screening programme which would constitute research.