The aim of the MuPlex software (28, 29) is to partition primer pairs into multiplex-compatible bins for SNP genotyping, and it does not employ any algorithm during primer selection to minimize the number of primers to amplify all targets, yielding a one-to-one correspondence between number of primer pairs versus number of targets. However, the MuPlex graph-based algorithm to partition primers into bins is more sophisticated than the simple binning scheme of MPP. In future work, MPP could be used to identify a universal set of primers and the backend of MuPlex used to optimize how they are binned into separate reactions.