The major reason for PICU admission was respiratory failure subsequent to pneumonia (Table 3) . Seven patients (3% of the global cohort) presented an Acute Respiratory Distress Syndrome (ARDS) and three had pleural effusion. Two patients were admitted for surveillance because of severe underlying disease. None of the 21 children presented seizures or signs of viral encephalitis ( Table 3 ). The median duration of PICU stay was four days and ranged from 1 to 90 days. 13/21 (59%) children received respiratory support with non invasive ventilation (NIV); eight (38%) required mechanical invasive ventilation for a median duration of six days (range 1 to 45). One previously healthy child presenting with severe ARDS followed by cardiac-respiratory arrest had to undergo Extra Corporeal Membrane Oxygenation (ECMO) support during 12 days, but survived with mild respiratory sequelae.