Resolution of the alveolar epithelial/capillary membrane damage that occurs during acute lung injury (ALI) requires a coordinated and effective tissue reconstruction program to re-establish a functional barrier [75] . Regeneration of alveolar epithelial cells and matrix turnover are controlled by regulatory pathways, while dysregulation of these pathways may result in amplification of the initial injury and disorderly repair, with sustained inflammation and development of pulmonary fibrosis [76, 77] . Since WNT/b-catenin signaling has been reported to be involved in epithelial cell injury [78] , Villar et al. [79] demonstrated that this pathway is modulated early during ventilator-induced lung injury. This modulation may represent a promising therapeutic target for attenuating or preventing the pathological consequences of acute lung injury.