The availability of an increasing number of pathogen genomes is boosting basic research as well as applied science. In the field of parasitological diagnostics, sequencing of parasites genomes also creates new opportunities. Annotated genomes and proteomes are available for some of the medically important protozoan pathogens, such as Plasmodium species and some Kinetoplastida species. Following the genome of the parasitic nematode Brugia malayi [14] , the genome of Schistosoma mansoni, a blood vessel dwelling trematode, has recently been released [15] as well as a draft genomic sequence for Schistosoma japonicum [16] and more genome data from various helminth species are to be expected in the near future (see for example http://www.sanger.ac.uk/ Projects/Helminths/ or http://www.nematode.net/). Currently, proteins predicted from ESTs, whole genomes or contigs are available for data mining already from a considerable number of helminth species. Using the sequence data available in the public domain, we have designed and tested a pathway for identifying novel antigens for serodiagnostic test development.