Results: The neuropathologic study revealed a intramedullary holocord tumor with secondary syringobulbia, cervical and lumbar syringomyelia. Histopathological examination of all specimen resulted in diagnosis of a pilocytic astrocytoma. Although no signs of atypia were present, an elevated proliferative activity of endothelial vessels was noted. Conclusion: Gross total resection of holocord and longitudinally extensive intramedullary spinal cord tumors can be achieved with preservation of long-term neurological function and also solved the syrinx. Objective: Epithelial cellular adhesion molecule (Ep-CAM) has been studied in many tissues and neoplasm, including thyroid and thyroid tumors. This is a preliminary study to assess the immunohistochemical expression of Ep-CAM in thyroid tumors using Ber-EP4.