Liver fi-brosis can be explained with an increased deposition of extracellular matrix (ECM). Chronic alcohol abuse is one of the main causes of liver fibrosis. Ingestion of polyunsaturated fatty acids (PUFAs) together with alcohol can aggravate the toxicity of alcohol. The degree of abnormal ECM degradation depends on the ratio of active matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). A recent work studied the influence of bis-desmethoxy curcumin analog (BDMC-A) on the expression of MMPs and TIMPs during alcohol and DeltaPUFA-induced liver toxicity. Administration of BDMC-A significantly decreased the levels of collagen and TIMPs and positively modulated the expression of MMPs. From this study, we can conclude that BDMC-A influences MMPs, TIMPs expression and that it acts as an efficient anti-fibrotic agent [37] .