The hit-rates observed among the top 1% of the screening set using the ''rank-by-number'' strategy are shown in Table 3 . By comparing the performance of all of the consensus ranking schemes tested, it appears that the consensus ranking does statistically outperform the best of the individual scoring function. The Surflex_Score pose extracted group produced 24 hits in the top 1% of the screening set when the quadruple-scoring scheme was applied. The improvements are not trivial. The best individual scoring function, jainScore, produces only 20 hits in the top 1% of the screening set.