Endoh et al. [103, 104] very recently presented an innovative strategy, called CLIP-RNAi (i.e. CPP-linked RBPmediated RNA internalization and photo-induced RNAi) combining delivery of a specific RNA sequence with enhanced photoinduced release of RNA from endosomes. This goal was accomplished by fusing the U1A RNA-binding domain (RBD) to the Tat peptide and extending the siRNA with a short stretch of nucleotides specifically recognized by this RBD. These complexes were efficiently internalized but exhibited a punctuate cytoplasmic localization pattern, indicative of endosomal entrapment. However, photostimulation of a fluorophore attached to the peptide led to a redistribution of complex into the cytosol followed by efficient RNAi-mediated gene silencing.