Although proteins and other molecules may contain information beside DNA genetic information, most information that can pass to next generation is in DNA, so DNA directly controls enough information to construct organism. All the processes not directly controlled by DNA, including post-translational protein modifications and interactions, are the functions of proteins and will proceed automatically when the proteins are synthesized. All the information necessary for these functions is already contained in DNA sequences. Therefore, we do not need to take the post-translational processes into consideration when calculating genomic information needed to construct an organism.