In a recent study, the ability of Egr-1 to bind KSHV ORF50 promoter (ORF50P) was described [6] . In this report, electrophoretic mobility shift assays (EMSA) and chromatin immunoprecipitation (ChIP) experiments were employed to determine the locations on ORF50P that have an affinity for Egr-1 binding. Our results demonstrated at least two targets that are likely crucial for mediating Egr-1 binding to ORF50P. These findings were confirmed through the use of mutation studies. In addition, we tested the ability of resveratrol, a naturally occurring product found in a variety of fruits and nuts [14] , in regulating MAPK signaling.Egr-1 expression.promoting virus latency. As such, the ramifications on the ability of Egr-1-induced transcription of ORF50 in viral pathogenesis are discussed.