PROLONGED MOOD DISORDER AFTER 3,4-METHYLENEDIOXYMETH-AMPHETAMINE (MDMA)USE: A CASE REPORT. S.D. Thakur 1 , L. Coberly 1 ; 1 University of Cincinnati, Cincinnati, OH LEARNING OBJECTIVES: 1) Recognize the potential for prolonged neuropsychiatric illness after methylenedioxymeth-amphetamine use. CASE INFORMATION: A 23-year-old male with no prior psychiatric history except polysubstance abuse, presented with sudden onset of anhedonia, mutism, avolition, feelings of guilt and worthlessness, and hypersomnia after an MDMA binge. The patient had severe paranoid delusions about eating and ultimately quit eating altogether. Hospitalization and a feeding tube were required for his malnutrition. The patient was diagnosed with major depressive disorder with psychotic features, and was started on venlafaxine, olanzapine, haloperidol, and benztropine. His symptoms have continued to persist for several months. He was discharged once but decompensated and attempted suicide within the week. Upon rehospitalization lithium augmentation therapy was implemented. It is postulated that his prolonged psychiatric illness was precipitated by his MDMA use. MDMA ingestion has been linked to acute psychosis, mood disorder, memory and cognitive disorders. Recent reports have implicated its involvement in prolonged mental disturbances as well.