We now introduce another useful technique to identify genes which correlate with the transitions. The challenge is to find genes which are related with the progression towards metastases profiles, even when we recognize that there the group of metastasis samples is heterogeneous (containing at least two groups). Since the final outcome of Figure 4 and Figure 5 is that the Normalized Shannon Entropy does not help much in this experimental scenario, we will concentrate only on one of the multiplicative factors of the Mcomplexities, the Jensen-Shannon divergence. We compute two P ave profiles, one with the normal skin samples only, and the other with all the metastasis samples (regardless their type). We will call the two divergences JSM0 and JSM5 respectively. We then compute the Spearman correlation of the profile of all gene probes in the array across the 37 samples to both JSM0 and JSM5. We have listed all probes according to the absolute value of the difference of these correlations, i.e. Abs. Diff. (probe) = |JSM0(probe)2JSM5