Objective: Classical Hodgkin Lymphoma (cHL) is characterized by the presence of a small percentage of malignant Hodgkin and Reed-Sternberg (HRS) cells amongst a reactive background. The role of angiogenesis in cHL is still unclear. The aim of the study was to evaluate the expression of VEGF-A, VEGFR-1 and VEGFR-2 and their correlation with clinicopathological parameters and prognosis. Method: The immunohistochemical expression of VEGF-A (VG1, Dako), VEGFR-1 (RB-9049, Neomarkers) and VEGFR-2 (sc-6251, Santa Cruz) was studied in a large cohort of 199 patients with cHL and the results were correlated with clinical characteristics and patient outcome. Results: The neoplastic HRS cells expressed VEGF-A, VEGFR-1 and VEGFR-2 in 90.3 %, 97.2 % and 94.1 % of the cases respectively and their expression levels were intercorrelated. Expression of VEGFR-1 and VEGFR-2 was significantly and positively correlated with early disease stage, absence of B-symptoms, WBC <15.000, Alb ≥4, IPS ≤2. VEGFR-2 was additionally positively correlated with male gender and ESR <50. All three molecules were statistically correlated with ramifications of blood vessels but not with microvessel density. Conclusion: Based on our results, we could speculate that, in contrast to solid tumours, the process of angiogenesis is probably an early event in neoplastic progression in the context of Hodgkin's Lymphoma.