The KwaZulu Natal site (population of 9,500,000 inhabitants) extends from the international borders with Swaziland and Mozambique in the north, to the province of the Eastern Cape in the south, while inland it is bound by the provinces of the Free State and Mpumalanga, and by the Kingdom of Lesotho. The project aims at vaccinating about 700,000 dogs regularly during the project duration. The effective veterinary structure involved in rabies control measures and, more recently, the stronger commitment from provincial authorities alleviated many of the logistical, financial, and managerial difficulties in the implementation and maintenance of successful dog vaccination strategies and have been critical factors in successful implementation to date. Since 2009, the program has already achieved reductions in dog and human rabies prevalence through mass mobile vaccination campaigns, as well as targeted sterilization and dog management programs [56] . The program has also led to notable improvements in the delivery of PEP, with fewer human deaths recorded at present.