Method: An accurate prediction should include both clinical features and histologic parameters as biopsy techniques continuously advance. 120 cases of uveal melanoma, either reviewed or prospectively managed in our Pathology Department, were included in a Log-logistic multivariate survival model that we have considered would best accomodate our data. The performance of the model was assessed by bootstrap re-sampling. Results: Extravascular matrix patterns, optic nerve invasion, tumorinfiltrating lymphocytes, tumor cytomorphology, nucleolar size and the mitotic count together with initial visual acuity have been found to be the most important predictors, ahead of the traditional TNM stage. The results are provisional but encouraging. Conclusion: There is still need for multidisciplinary approach and multicenter collaboration in an effort to elucidate the uncertainty related to the best management of one of the most traumatising types of cancer.