Another validation method based on Fischer randomization was also performed on the training set compounds to verify the quality of Hypo1. In this validation process, a confidence level of 95% was selected and thus 19 spreadsheets (Table 4 ) were generated. The data obtained from this validation method did not produce any better statistical values compared with that of Hypo1. Out of the 19 runs, only three had a correlation value between 0.90 and 0.92 which was comparatively less than the correlation value of Hypo1. The total cost values of all randomized models and RMSD values were higher than Hypo1, which is not appropriate for a good pharmacophore model. Therefore, this validation test also endows the Hypo1 with a high level of assurance.