Objective: A myeloid sarcoma is a tumour mass consisting of myeloid blasts with or without maturation occuring at an anatomical site other than the bone marrow. Every site of the body can be involved, skin, lymph node, gastrointestinal tract, bone, soft tissue and testis. %10 cases presents at multiple anatomical sites. Method: The current case is 75 year old woman presenting with nasal polyp and underwent polypectomy. The polyp was 2,5 cm in diameter and had a bloody appearance. By microscopic examination there was a diffuse infiltration of neoplastic cells under the cilliated epithelium. The mitotic index was high in neoplastic lymhoid cells. Immunohistochemical study was helpful for the differential diagnosis. Objective: The aim of this study was to describe the epidemiology and anatomo-clinical features of the ear, nose and throat (ENT) lymphomas in the Centre of Tunisia. Method: All ENT lymphoma cases diagnosed in the Pathology Department, Farhet Hached Hospital, Sousse during a 15-year period were analyzed. Results: A total of 34 cases of ENT lymphoma were reported (21 males, 13 females) with a sex-ratio of 1.4. The age at diagnosis varied from 9 to 85 years with a median age of 56.5 years. The majority of ENT lymphoma cases (81 %) were of B cell type including large B-cell lymphoma (58 %) and small-cell B lymphoma (23 %). Nasopharynx and tonsils were the most involved areas with 44 % and 42 % of cases, respectively. According to the Ann Arbor staging system, these lymphomas are diagnosed in the stage II (42 %) followed by stage I (30 %). Conclusion: The most frequent lymphoma developed in ENT region was B cell lymphoma, especially located in nasopharynx and Tonsils. Results: A total of 44 cases were reported (26 males, 18 females) with a sex-ratio of 1.4. The median age was 10 years (range: 3-15 years). Lymph node lymphomas were the most frequent accounting for 63.6 %, followed by ENT, mediastinum, and haematopoietic system (6.8 % each one); cutaneous and digestive location were less frequent (4.5 % each one). Among the 44 patients, 23 (52.3 %) had had Hodgkin's lymphoma and 21 (47.7 %) had had non-Hodgkin's lymphoma (NHL). Diffuse large B-cell lymphoma was the most diagnosed (57 %) followed by Burkitt lymphoma (23.8 %) and T-cell lymphoma (9.5 %). According to the Ann Arbor staging system, 29.6 % of patients were diagnosed in an advanced stage. Method: We present a case of composite AILT and diffuse large B-cell lymphoma (DLBCL) A 45-year-old woman with multiples lymph nodes. Biopsy of inguinal node was performed. Three months later the patient had enlarged cervical node which was removed. Results: Firstly, the inguinal lymph node was diffusely infiltrated by small-medium size lymphocytes with scanty cytoplasm. The nuclei were irregular. Several large cells were observed in a background of prominent arborizing high endothelial venules. The small cells were CD3 positive. The large cells were CD79a, CD30 positive. Theses cells showed nuclear positivity for EBER by ISH. Secondly, the cervical lymph node showed large areas of necrosis admixed with pleomorphic and medium size T lymphocytes. There were a population of neoplastic EBV + pleomorphic B lymphocytes; some of them with RS-like morphology. We performed B and T-cell clonality studies. We detected TCR-gamma T-cell and IgH B-cell gene clonal rearrangement. Conclusion: Occasionally IgH gene rearrangement has been detected but only a few cases have demonstrated, morphologically, composite AILT and EBV-associated diffuse large B-cell lymphoma (DLBCL).