Using the same methodology, serum-starved HFF cells were exposed to 1000 particles per cell of virions lacking either gD, gB or gH and RNA was extracted for cDNA synthesis immediately (0 h) or after 6 h. Table 2 gives the results of three independent experiments for those genes that were differentially expressed between 0 h and 6 h post treatment and is compared to the initial microarray results in Table 3 . It is striking that in virtually every instance where gene expression is modified by virion binding, gD appears to be the key effector. Virions lacking gH or gB had were capable of altering cellular gene expression while those lacking gD had no significant effect. The results can be summarised as follows.