In 2004, a separate group of researchers from several universities found that glucose transporter 4 (GLUT4) translocation from the intracellular microsomal membrane to the plasma membrane was significantly increased in the muscle cells of mice treated orally with corosolic acid (P50.05, 24). This result is both interesting and puzzling. GLUT4 is the major glucose transporter protein in both muscle and adipocytes and GLUT4 is insulin-responsive (4, 25) . However, since corosolic acid does not possess insulin-like glucose transport stimulatory activity, the process that leads to GLUT4 translocation is not known. The GLUT4 membrane translocation mechanism initiated by corosolic acid as described (24) must be independent of the IR mediated signaling pathway since corosolic acid does not use this pathway for its activity. In 2006, the same group of researchers found that corosolic acid significantly reduces blood glucose levels and plasma insulin levels in KK-Ay diabetic mice (26) . Additionally, this group of researchers published another article in 2006 in which they showed that corosolic acid significantly lowered blood glucose levels at the 90 min mark in an oral glucose tolerance test done on type 2 diabetic patients (27) . However, no statistical difference between the treated group and the control group was found for any other time point during the test (27) .