Since the pharmacological arrest of the osteoclast is the mainstay of treating systemic bone loss, drug delivery strategies that target the osteoclast directly would provide a potential therapeutic advantage at reducing systemic bone loss by selectively delivering an antiresorptive drug "cargo" to the osteoclast. Antibodies are renowned for their exquisite specificity of target recognition and generate highly selective outcomes following their systemic administration. As the RANK receptor is predominantly expressed on the surface of mature osteoclasts, we hypothesized that an anti-RANK antibody would facilitate an effective osteoclast targeting platform for the delivery of antiresorptive drug directly to the resorbing bone cells.