This discussion brings us to one of the gene families we have already discussed in this paper, the aquaporins [184, 656, 657, 658, 659, 660, 661] . They are considered the primary water channels of cell membranes [662, 663, 664, 665] . The specific functions of each member of this family are now being slowly mapped by several research labs around the world [666] . Their clinical role in cancer [667, 668, 669, 670, 671, 672, 673, 674, 675] ,obesity [676] , malaria [677, 678] and other diseases is emerging [657, 679, 680, 681, 682, 683, 684, 685, 686, 687, 688, 689] . In [690] , our group observed the dowregulation of AQP3 in all melanoma cell lines studied of the NCI-60 dataset of Ross et al.; this dowregulation was also observed for the CNS and Renal cell lines. AQP3 was relatively upregulated for Leukaemia and Colon cell-lines (we refer the reader to the Supplementary Material of [690] for details). Inhibition of AQP3 in prostate cancer cells was already proposed as a mechanism that increases the sensitivity to cryotherapy treatment [691] .