[K294fs+T87_Q113del]) and one infantile (p. [Arg22Cys+Arg222Cys] ). For the third subgroup of patients no mutations were detected either in the GLDC, AMT, or GCSH gene suggesting a different primary gene lesion as responsible for the disease. Background: Low birth weight (LBW) is associated with increased morbidity and mortality for the newborn and increased risk on chronic diseases in adulthood. Choline has an essential role in the integrity of cell membranes, methylation reactions and memory development.