(2) Begin the cross-regional simulation model. (4) Select randomly the initial outbreak region j. Set n = 1. (c) Re-estimate regression equations for each region k ∈ B n ∪ C n using the single-region simulations, where each simulation is initialized to the current outbreak status in the region (alternatively, use (4) and (6)). (d) Solve the resource distribution model for region j. (e) Update the total resource availabilities.