Our aim was to evaluate two interventions during curative cancer treatment in a RCT and to determine the role of physical activity. Patients (N=220) with various malignancies receiving cancer treatment with curative intent were assessed before (T1) and two months after cancer treatment (T2) and randomized to a brief nursing intervention (BNI), cognitive behaviour therapy (CBT) or usual care (UC). Fatigue was measured with the Checklist Individual Strength, physical activity with actigraphy and questionnaires.