We now turn to another aspect of the statistical complexity and entropy analysis. We note that Figure 2 shows that the metastases samples have a clear reduction on Normalized Shannon Entropy in comparison with the values observed for the normal samples. At the same time, metastases samples, as expected, have higher Mnormal complexity than the normal samples ( Figure 2 ). It is then interesting to evaluate the value of the Jensen-Shannon divergence of these samples and to identify the genes that most correlate with the variations of Jensen-Shannon divergence to quantify one of the factors that is related to the statistical complexity changes.