CBA data was analysed using SPSS statistical software. Boxwhisker plots were created from the CBA FACS raw data. Sixmonth and 12-month samples were compared to the acute samples using the non-parametric two-tailed Wilcoxon signedrank test for related samples to determine statistical significance. Each acute phase, 6-month and 12-month cytokine sample sets were statistically compared to healthy control CBA data using the non-parametric two-tailed Mann Whitney Test for unrelated samples.