Lipid rafts have been implicated as the sites for a great number of signaling pathways (Allen et al., 2007) . Perturbation of, or changes, in lipid rafts could therefore affect neuronal signaling, including cholinergic transmission. As cholinergic hypofunction is key to the pathogenesis of AD (Schliebs, 2005; Schliebs and Arendt, 2006) , there are strong links between lipid rafts, neuronal signaling pathways, and AD.