A 39 year old female admitted Neurosurgery Department with painful coccygeal mass. Magnetic resonance imaging revealed a coccygeal, well-demarcated, non-enhancing mass of 4×5 cm in diameter. The mass did not have any connection with the spinal cord. It was completely excised and grossly the cut surface of the encapsulated mass was soft. Microscopically the tumor was comprimised of myxoid stroma with pseudopapillary structures around hyalinized vessels. The tumoral cells showed intracytoplasmic dot-like positivity with EMA. There were no mitosis, and the Ki67 labeling index was low. Conclusion: Extraspinal MPEs are rare and the most common location is sacrococygeal area. These masses are often preoperatively misdiagnosed as pilonidal sinus. Unlike the CNS MPEs, extraspinal MPEs have a potential to metastasize even if they do not show any anaplastic morphological feature. Long term follow-up is recommended as metastases can occur up to 20 years after initial presentation. Objective: Cerebellar liponeurocytoma (CL) is a rare neoplasm with neuronal, astrocytic and lipomatous differentiation arising in adults. The entity is considered as a grade II neoplasm in the last WHO classification of central nervous system tumours. We show two typical cases of this entity stressing the spectrum of histological changes and its differential diagnosis. Method: Patient 1 is a 72-year-old woman with a history of headaches and instability. CT scans and MRI showed a 5 cm in diameter relatively ill-defined, poorly enhanced, round tumour mass in the left hemisphere. Patient 2 is a 56-yearold woman with a history of headaches and instability. MRI showed a 6.5 cm in diameter well-defined triangular lesion in the right hemisphere. Results: Complete surgical resection was achieved in both cases. Both tumours showed highly cellular neoplasms composed by round to polygonal cells with scant cytoplasm and round nuclei with fine chromatin pattern. Mitoses were not seen. Well differentiated lipomatous cells grouped in irregular nests were intermingled with the predominant neuronal component. Conclusion: Cerebellar liponeurocytomas are located in the cerebellar hemispheres and pursue a non aggressive clinical course, with local recurrences detected mainly after incomplete resections. The typical adipous tissue is the result of a lipidization process and not a true metaplasia. Objective: Giant cell tumor of bone is an uncommon neoplasm that accounts for about 5 % of all bone tumors. It usually involves long bones and is very rarely encountered in the skull where it mostly involves the sphenoid and temporal bones. It is a benign neoplasm but can be locally aggressive. Method: We present a case of a 32 year old woman with history of multiple sclerosis whose routine CT scan revealed a mass with corrosive features and calcification situated at the petrous portion of her left temporal bone. A biopsy was sent to our laboratory. Results: Histopathologic examination revealed a neoplasm composed of sheets of oval mononuclear cells, with uniformly distributed nuclear chromatin, evenly intermixed with numerous giant cells that contain a variable number of nuclei with features similar to those of mononuclear cells. Cytoplasm of either cell type was eosinophilic and cell borders were indistinct. Mitoses were scarce and regular. Foamy histiocytes, hemosiderin and microscopic nodules of cartilage formation were also noted. Conclusion: Although giant cell tumor is a benign neoplasm its' localization in this case posses a threat that should be managed surgically and by adjuvant radiotherapy if complete excision is unobtainable.