Viruses recruit the cellular machinery to support their own multiplication and elicit an early host response to overcome the unwanted viral invaders. In our contribution we investigated the ability of caveolin-1, a multifunctional protein, to interact with components in the influenza A virus life cycle and to interfere with influenza A virus production. Cav-1 represents an organizing element at the plasma membrane and serves on localization and accumulation of proteins in lipid rafts and transmission of signalling events [24] . Furthermore, the protein contributes to intracellular cholesterol transport and has been identified as the main determinant of caveolae, invaginations of the plasma membrane used for entry of molecules and particles into the cell.