Although anti-malarial drug medication is the only intervention of proven efficacy to treat severe malaria, it is very important to monitor and treat severe forms with organic dysfunctions in ICU [37] . Use of controlled low dose gamma irradiation to sterilize allograft tendons for ACL reconstruction: biomechanical and clinical perspective As reviewed here, numerous biomechanical and clinical studies support the use of controlled, low temperature irradiation of allograft tendons, to provide both excellent clinical results and medical-device grade sterile allografts with minimal risk of disease transmission. The preferred method of terminal sterilization for tendon allografts, gamma irradiation, remains a concern to some surgeons. While some older studies have shown that higher, uncontrolled doses of gamma irradiation ([3 Mrad) can have detrimental effects on the strength of allograft tissue, numerous studies suggest that the currently used practices of low dose, controlled, low temperature gamma irradiation are effective to achieve terminal sterilization without detrimental impact on allograft tissue strength. In this review, irradiation methods are presented as well as biomechanical, clinical, and safety assessments of irradiated tendons used for ACL reconstructive procedures.