The high mobility group (HMG) nuclear proteins were discovered in 1973 in an effort to better define the specific regulators of gene expression (18) . This group of non-histone, chromatin-associated proteins has since been characterized to be involved in DNA organization and regulation of transcription. This family of proteins shares structural characteristics which make them unique from other chromosomal proteins. These characteristics include transcripts with long AT-rich 3′ untranslated regions as well as carboxy-terminal regions which are highly negatively charged (19) . HMG proteins are constitutively expressed in the nucleus of eukaryotic cells. Collectively, they share functional motifs that bind specific DNA structures and induce conformational changes without specificity for target sequences.