Kawachi Emi 1 , Murayama Kei 1 , Fushimi Takuya 1 , Fujinami Ayako 1 , Ajima Masami 1 , Harashima Hiroko 2 , Mori Masato 3 , Okazaki Yasushi 4 , Takayanagi Masaki 1 , Ohtake Akira 2 1 Div Metab Dis, Chiba Child Hosp, Chiba city, Japan 2 Div Ped, Saitama med Univ, Saitama, Japan 3 Div Ped, Jichi med Univ, Tochigi, Japan 4 Translational Reser Cent,Saitama Med Uni, Saitama, Japan