Outcome and severity of CAP patients related to genetic variants at SFTPA1, SFTPA2 and SFTPD genes When fatal outcome was analyzed, patients who died within the first 28 days showed a higher frequency of haplotypes 6A 12 , 1A 10 and 6A-1A, and a lower frequency of the major SFTPA1aa19-T and aa219-C alleles and of haplotypes 6A 3 and 6A 3 -1A 1 (see Table 4 ). Similar results were observed when 90-day mortality was analyzed (see Table 4 ). For the observed odd-ratios, the power of the tests with a significance level of 5% was 82.64% when the protective effect of 6A 3 -1A 1 on 28-day mortality was evaluated, and 81.45% and 80.79% concerning the effect of 6A 3 and 6A 3 -1A 1 on 90-day mortality respectively. Kaplan-Meier analysis ( Figure 2 ) and log-rank test (Table 4 ) also showed significantly different survival for the above mentioned alleles and haplotypes. Cox Regression for 28-day survival, adjusted for age, gender, hospital of origin and co-morbidities, was significant for haplotypes 6A 12 and 6A-1A, and it remained significant for haplotypes 6A 3 and 6A-1A when 90-day survival analysis was performed (see Table 4 ). We also analyzed Cox Regression adjusted for hospital of origin, PSI and pathogen causative of the pneumonia, and we found similar results: for 28-day Figure 1 Genomic organization, location of SNPs, and linkage disequilibrium (D') map for SFTPD, SFTPA1 and SFTPA2 genes. SNPs: Single-nucleotide polymorphisms. All the D' values higher than 0.3 were statistically significant (P < 0.05). Linkage disequilibrium was measured in the control group.