Clinical manifestations range from self-healing cutaneous lesion to fatal visceral form, and this variety can be attributed in part to the respective parasite species, and each presents specific relationships with the host and diverse mechanisms of pathogenesis [3, 4] , which represents an additional difficulty for the development of treatments and vaccines. On the other hand, T. cruzi is the agent of Chagas disease, which is present from southern Argentina to the southern USA. An estimated 16-18 million persons are infected in the Americas and close to 100 million people are at risk of infection. After a short benign acute phase (a few weeks) and a very long (several years) asymtomatic phase, about 30-40% of infected patients develop chronic chagasic cardiomyopathy and eventualy die of heart failure. Current chemotherapy relies on nitrofurans (Nifurtimox), or nitroimidazoles (Benznidazole). However, the usefulness of these drugs is limited by their reduced efficacy (mostly during the early stages of the infection), serious side effects, and the emergence of drugresistant strains of parasites, and new treatments are slow to develop [5] .