Transcriptional regulation involves complex interactions of diverse proteins, or transcription factors, with specific DNA sequences in the noncoding regions of target genes. Furthermore, cells respond to environmental stimuli and to developmental signals by altering expression of gene networks. The limited number of transcription factors suggests that few, if any of these proteins exert their activity exclusively on a single gene; rather, they bind to conserved sites in several genes to coordinate their expression (Wagner 1999; Pennacchio and Rubin 2003) . In situations in which there are no clinically acceptable inhibitors or other modulators of clinically relevant proteins, elucidating mechanisms by which these genes are regulated and identifying other coordinately regulated genes may reveal novel strategies by which disease processes may be disrupted or controlled.