We used multivariate logistic regression and Cox regression models with a backward technique to select variables that predicted a fatal outcome, including clinical severity and the inflammatory markers studied, such as age, gender, CURB-65, SOFA score, APACHE II, pneumonia severity index, HMGB-1, sRAGE and RAGE. Correlation between clinical severity scores and immunologic markers at admission, and between the markers, was detected using Spearman's correlation coefficient.