Conclusions: This simple experiment clearly shows that the changing diet from steatohepatitis-causing MCDD to MCCD triggers the resolution of inflammatory and fibrotic reaction in the liver, suggesting that food intake is a very important factor for controlling the state of fat and pathology of the liver. ER stress is involved in the process. Background: Liver fibrosis results from chronic damage to the liver in conjunction with the accumulation of extracellular matrix proteins, which is a characteristic of most types of chronic liver disease. Under injury conditions, hepatic stellate cells (HSCs) are activated to transdifferentiate into myofibroblasts, which are capable of secretion of many connective tissue elements, especially collagens I, III, and IV. Gynostemma pentaphyllum is a popular folk medicine that has been used for treatment of hepatitis in Asia. Gypenosides are the major saponins derived from G.