Barbiturate therapy for refractory ICP High intracranial pressure (HICP) frequently complicates severe traumatic brain injury, aSAH and other neurological disorders. Raised intracranial pressure has been consistently associated with poor neurological outcome. Treggiari [50], in a systematic review of trauma patients, evaluated the management of raised ICP and related neurological outcomes. ICP refractory to therapy and the response to treatment are very good predictors of neurological outcome compared to absolute ICP values. Relative to normal ICP, raised ICP was associated with a 3.5-to 6.9-fold increase in mortality. Raised but reducible ICP was associated with a 3-to 4-fold increase in the probability of death or poor neurological outcome. Refractory ICP pattern was associated with a dramatic increase in the relative risk of death (odds ratio [110) . The same applies to aSAH patients [51] .