been suggested that this protein may inhibit cap-dependent translation while promoting internal ribosome entry site-mediated translation (43) . This too may be significant because at later times in infection adenovirus makes use of a ribosome shunting method to promote the translation of its structural proteins at the expense of cellular mRNA translation (61) . In a similar vein, ribosome assembly is regulated by eIF6, and it too may be used by adenoviruses to maximize the suitability of the infected cell for viral protein expression (41, 62) .