pentaphyllum. In previous study, gypenosides have hepatoprotective and anti-fibrotic activities in rat chronic liver injury induced by CCl4, and anti-proliferative effect in rat isolated HSCs. Methods: In cultured HSCs model, we detected type1 procollagen protein and mRNA by Western blot and RT-PCR. Result: we found that G. pentaphyllum inhibited type1 procollagen protein expression in 66% at 48 hours. Furthermore, G. pentaphyllum also inhibited type1 procollagen 1 and 2 mRNA expression in 39% and 11% respectively. In addition to transcriptional inhibition, we found that G. pentaphyllum also enhanced the degradation rate of type1 procollagen protein. Base on the effect of enhancing protein degradation, we used some protease inhibitors like CA-074 Me, z-FA-fmk, AEBSF, TPCK and TLCK to identify the potential target of G. pentaphyllum. On the other hand, in the ubiquitin-proteasome system analysis, we quantified the change of some target proteins of proteasome in the presence or absence of G. pentaphyllum. Conclusion: G. pentaphyllum reduced type1 procollagen protein by inhibiting transcription and enhancing protein degradation. Aim: Excessive oxidative stress in diabetic patients has been implicated in the pathology and complication of liver. The present study was designed to examine whether ginger has a direct hepatoprotective effect in diabetic cases. Methods: Wistar strain albino rats were selected for this study. The rats were divided into 4 groups: (i) control, (ii) ginger treated (200mg/kg b.w. orally, 30 days) (iii) diabetic (50 mg/kg b.w., i.p.) and (iv) diabetic + ginger treatment. The lipid metabolic profiles such as total cholesterol, triglycerides, phospholipids and lipid peroxidation as stress markers and histopathological studies were carried out to assess the damage in hepatic tissue. Results: Ginger treated diabetic rats demonstrated significant reduction in glucose levels as compared to the nontreated diabetic animals. Diabetic rats have shown increased total cholesterol, triglycerides, phospholipids and lipid peroxidation content in hepatic tissue compared to control, indicate prevailing of oxidative stress and alterations in fatty acid metabolism in these rats. Further, degenerative changes of hepatic cells in diabetic group are minimized to nearness in structure by administration of ginger as evinced by histopathological examination. Conclusion: We summarize that the hypolipidemic and antioxidant compounds present in ginger may be useful in delaying the complicated effects of diabetes. This results also reveal that ginger possess hepatoprotective properties in diabetic cases.