Method: STAT3 knockout cells (S3KO cells) and liverspecific STAT3KO (L-S3KO) mice were generated. Cellular adhesion was analyzed by light/electron microscopy. Expression of adhesion molecules was examined by immunohistochemistry and western blot analysis. Protein expression and cellular adhesion were also examined in the pre-/post-hepatectomy liver tissue in control and L-S3KO mice.