At present, there are many ongoing studies on genetic background of renalase. Zhao et al have found that renalase gene polymorphysim is associated with primary hypertension, indicat-ing this gene may become the novel marker of genetic susceptibility in essential hypertension [30] . Farzaneh-Far discovered that renalase gene polymorphism also is associated with ventricular hypertrophy [31]. Buraczynska found that an association between renalase gene polymorphism and hypertension in type 2 diabetes [32] . Stec et al investigated patients with end stage renal disease and found that renalase gene polymorphism is associated with hypertension among these patients [33] .