Each category analyzed included three or more tissue sections per mouse and three or more mice per condition, except where larger sample sizes are noted in text and/or figure legends. One-way analysis of variance (ANOVA) with post hoc Tukey's multiple comparison test was used to determine significant differences among stages of disease progression or treatment. Unpaired Student t-test was used to compare between FGF2 genotypes in nonlesioned mice. Significance of an FGF2 genotype effect across multiple treat-ment conditions was calculated using a two-way ANOVA. No statistical comparisons were made between mice with different genetic backgrounds (i.e. C57Bl/6 mice and FGF2 mice).