Particularly, silymarin (an extract of milk thistle) is the most popular product taken by subjects with liver disease and especially by those with hepatitis C virus infection [11] . Seeff et al. [12] found that 41% of outpatients with diagnosis of liver disease had used some form of CAM. Herbal products are often used to improve well-being and quality of life [13] and to ameliorate side effects in patients on antiviral treatment, as fatigue, irritability, and depression: lessening of these symptoms might permit a higher compliance and avoid the need to limit the dose and finally withdraw inter-feron.