The FluGenome database is updated automatically every night. New sequences are downloaded from the NCBI Influenza Virus Resource (ftp://ftp.ncbi.nih.gov/ genomes/INFLUENZA/) and added into the FluGenome database. The lineage information predicted for new sequences is used to update Segment, Genome and Genotype tables if necessary. For sequences already in the database, the script checks to see what information needs to be updated, and the sequences entries are flagged for further validation.