Several groups have investigated the contribution of TLR signaling to innate immunity against Brucella infection in the mouse model. The consensus opinion is that TLR2 is not required to control Brucella infection in the mouse (Campos et al., 2004; Copin et al., 2007) . However, TLR2 has been shown to be important for cytokine production (Huang et al., 2003; Giambartolomei et al., 2004; Weiss et al., 2005; Macedo et al., 2008; Zwerdling et al., 2008) , MHC-II expression and down regulation of the type I receptor for the Fc portion of IgG (FcγRI, CD64) (Barrionuevo et al., 2011) in tissue culture.