Preclinical studies have shown that Emblica officinalis (P. emblica) protect against ethanol-induced hepatotoxicity (reviewed in [132] ). Animal studies showed that the fruit extract improved plasma enzymes level, reduced lipid peroxidation, and restored the enzymatic and nonenzymatic antioxidants level in alcohol-induced liver disease, this action is probably due to tannoid, flavonoid and NO scavenging compounds present in the extract [133] [134] [135] . Phyllanthin restored the antioxidant capability of rat hepatocytes including level of total glutathione, and activities of superoxide dismutase (SOD) and glutathione reductase (GR) which were reduced by ethanol [136] and P. amarus-modified alcohol and thermally oxidized PUFA-induced fibrosis in rats because decreased the levels of collagen and TIMPs and positively modulated the expression of MMPs [120] .