The chemopreventive effect of silymarin on HCC has been established in several studies using in vitro and in vivo methods; it can exert a beneficial effect on the balance of cell survival and apoptosis by interfering cytokines. In addition, anti-inflammatory activity and inhibitory effect of silymarin on the development of metastases have also been detected. In some neoplastic diseases, silymarin can similarly be administered as adjuvant therapy. 9.5. Phyllanthus. Phyllantus Emblica exhibits a variety of pharmacological effects including antiinflammatory, antipyretic, antioxidant and anti-mutagenic effects [174] . The active principles of extracts of P. emblica have demonstrated anti-proliferative effects in several cancer cell lines both in vivo and in vivo, thanks to their ability to interfere with cell cycle regulation via the inhibition of cdc 25 phosphatase and partial inhibition of cdc 2 kinase activity [175] .