Objective: In this study, we evaluated 81 synovial sarcoma cases, who had been referred to our tertiary tumor center during the last 20 years. We applied bcl-2, c-myc and survivin as immunohistochemical markers and evaluated the relation with conventional prognostic findings and prognosis for those 64 patients who have follow-up. Method: In this study; ten-year tumor free survival rate was 38 % reflecting the agressive behaviour of synovial sarcoma. Tumor grade was the most valuable prognostic input. Progression free survival (PFS) was 159 months for gradeII cases (40 cases) and 36 months for gradeIII cases (24 cases) (p=0,000). Results: Immunohistochemically, there was weak relation between bcl-2 staining intensity with prognosis. Overall survival was 211 months for weak or negative cases (9cases), 132 months for focally intense cases (21cases) and 101 months for diffuse and intense cases (34 cases) (p= 0,042). There was also weak relation with c-myc staining pattern with prognosis. Overall survival was 193 months for c-myc negative cases (25cases), 114 months for cytoplasmic positive cases (23cases) and 68 months for nuclear positive cases (16 cases) (p=0,043). There was no relation between survivin and prognosis. Conclusion: In conclusion; tumor grade is the most valuable prognostic parameter in synovial sarcomas. Immunohistochemically c-myc and bcl-2 staining have weak relation with synovial sarcoma prognosis.