GDC captures the density and topological complexity of up to 4-deep network neighborhood around a node. Since we have demonstrated significant enrichment of GDC-central proteins in BC genes, this means that genes that are involved in key biological processes occupy topologically complex and dense parts of the human PPI network. Similarly, since we have demonstrated significant enrichment of DSs in BC and SP genes, this indicates that proteins that are vital for normal cellular functioning reside on the ''spine'' of the network that dominates, i.e., connects, all other parts of the network. Hence, the notion of network domination seems to capture the topology required for passing cellular signals efficiently throughout the network.