Several intermediates in lipid catabolism were also detected in the replication complex membranes (palmitic acid, MG and DG). Analysis of these intermediates suggested the up regulation of pathways for PC hydrolysis and triacylglycerol (TG) metabolism. The latter pathway is responsible for regulating lipid homeostasis and energy production in the cell through the metabolism of lipid droplets [49] . Through the action of lipases the degradation of lipid droplets results in the release of palmitic acid, DG and MG [36] . These metabolic products are substrates for mitochondrial boxidation as well as intermediates (fatty acids) in the synthesis of new lipids. DENV infected cells show a high prevalence of these species compared to mock infected cells.