Background: Pressman (2005) found that high levels of momentary or experiences of loneliness were associated with elevated morning and evening cortisol. Recently, it is thought that the salivary cortisol awakening response (CAR) can serve as a reliable marker of HPA axis to respond to stress. The CAR is greater in people under chronic work stress and on the work day than the weekend. We recently demonstrated that the difference on this weekday and weekends is an adequate responsiveness to adapt to stress. However, there are no studies that investigate the relationship between the CAR and loneliness on the work days and the weekends in women. The present study was to investigate the relationship between the CAR and loneliness on the work days and the weekends in women. Methods: The participants were healthy 90 women (20-50 years old). Loneliness was evaluated using the revised UCLA loneliness scale (Russell et al., 1980) and participants were classified into high (average+1SD) (n=13) or low loneliness groups (average -1SD) (n=13). The saliva samples were collected over the work days and the weekends. Participants were instructed to collect saliva on six occasions each day: before sleep, immediately on awakening, 30 minutes after awakening, and then as near as possible to 10:00 am, 12:00 pm, and 3:00 pm. Results: CAR was larger on weekends in the high loneliness group than the low loneliness group. However, there were no significant differences in CAR on workdays between subjects with higher loneliness level and with lower one. In addition, there were significant differences in CAR on low loneliness group between workdays and weekends but not in high loneliness group. Discussion: Loneliness was associated with a promoted CAR, especially on weekends. These results indicated that the CAR and cortisol levels on high loneliness people showed no significant differences between work days and weekends due to allsotaic load that the HPA system is always activated. Background: It is a common stereotype, that women experience decrease in memory function during pregnancy. Previous studies about memory changes associated with pregnancy showed inconsistent Results: Working memory is a type of a short-term memory that is responsible for monitoring, keeping and applying information. A decrease of working memory function may lead to unexpected mistakes, absentmindedness and as a result to anxiety stress and decrease in self-esteem. Current research assesses the changes in working memory of healthy pregnant women. We also evaluate the influence of other variables such as depression, sleep changes, and negative self-beliefs on working memory. Materials and methods: Healthy pregnant women going for routine prenatal care were enrolled in the study. Overall 25 women were approached and agreed for participation. Control was matched for age and consisted of 10 non-pregnant women. Validated neurocognitive tests battery (Symbol-Digit Modalities Test and E-prime computer based test) was used to evaluate working memory function. Results: There was no significant difference between the groups in scores of memory encoding and retrieval. Depression and insomnia were not associated with changes of the working memory. Negative self-perception on Symbol-Digit Modalities Test was associated with decrease in working memory function (r=−.43). Conclusion: We failed to prove that pregnancy causes changes in the working memory. Self-perception reduces memory performance in both control and experimental groups. The prevalence of overweight and obesity has reached epidemic proportions, also in the Netherlands. Weight gain prevention interventions have shown to be feasible within the occupational health services, but are hardly being implemented by occupational physicians (OPs) due to a lack of methods and materials. The aim of this study is to 1) develop, 2) evaluate, and 3) implement a weight gain prevention guideline to be used by OPs. Following the standard template of the Netherlands Society of Occupational Medicine and using the Intervention Mapping protocol, a draft guideline was developed based on literature, interviews with employers, OPs and employees, input from an external project group consisting of OPs and lifestyle experts, and input from independent lifestyle experts. Based on all sources mentioned above, the developed guideline consists of clear cut recommendations for OPs to 1) advise employers to promote employees' physical activity and diet and 2) counsel employees to adopt a physically active and healthy diet behaviour. Tools to implement recommendations consist of a minimal intervention strategy to counsel employees, and a scan to assess the obesogenic environment. The guideline is now being evaluated in a RCT among 30 OPs and 350 employees. If proven effective, this weight gain prevention guideline will be implemented on a larger scale within the occupational health services in the Netherlands. Background: Health policy in the UK and the USA supports the design of health services for people with long term conditions (LTC) to be conducive to self-management support. The Wagner's chronic care model suggests that self-management support needs to be embedded in the system. Coote suggests that co-production can be applied to health care. It is a model in which true partnership is based on the active input of recipients in the provision of their own care however it is at best 'too flexible' to guide practice. Aims: To define the key observable behaviours that clinicians and patients require for co-productive interactions in LTC consultations. Methods: A convenient sample of eleven UK and US experts in self-management support and communication skills were interviewed for an hour using a semi-structured format. The transcripts were analyzed thematically. Results: Clinicians and patients need to enter in a partnership, recognizing mutual expertise within a long term relationship; consultations should include discussions about self-management strategies used to develop a highly personalized solution; shared decision making should develop e.g. over health priorities. This means negotiating an agenda, setting goals and agreeing in a followup; the development of rapport is important to engage patients in behaviour change and co-production of health requires a system that facilitates joint decision making. The final model will help to develop a measurement tool using the Roter Interaction Analysis System to assess co-production of health in video-recordings of real life clinician-patient consultations across the UK.