The combination of xiaoyaosan prescription plus antidepressants group may have significant beneficial effect compared to the antidepressants group. The onset time are variable may depended on the form of prescription such as pills and decoctions. Yang and Xie [10] Li et al. [31] Ma [27] Zhang [14] Huo et al. [28] Luo et al. [25] Wang [23] Yang et al. [ Two meta-analysis on HAMD scores showed significant heterogeneity. It may due to the different intervention and treatment time or the methodology quality. The significant heterogeneity on TESS scales may due to the dosage of the antidepressants.