Objective: Astrocyte elevated gene-1 (AEG-1 also known as Metadherin) is associated with various aspects of tumor malignancy. The aim of this study was to investigate P53 relationship between AEG-1 and prognostic parameters. Method: This study was made 50 paraffin blocks (tumoral samples), which were histopathologically diagnosed at department of pathology from 2005 to 2011. Subtypes of the cases were 24 (48 %) clear cell renal cell carcinomas (RCC) and 26 (52 %), non-clear RCC respectively. By immunohistochemical analysis, we investigated AEG-1, P53 expression in carcinomas of kidney and we determined its relationship with clinicopathological parameters. Results: There were significant relationship between increased AEG staining score and tumor capsule (P=0.01), lymphovascular invasion (p=0.015) and significant relationship between the increased diameter with the increase of p53 (p=0.028). There were significant correlation between increased diameter of tumor and degree of increase the Fuhrman (p=0.02). Conclusion: High AEG-1, P53 expression correlates with prognostic parameters in the RCC. In addition, AEG-1, P53 expression in RCC may be associated with tumor progression.