Our results show no benefit of late neuraminidase treatment. In Israel, a retrospective cohort study documented a higher rate of complications after admission. 12 Severe complications (excluding hypoxia and uncomplicated pneumonia) occurred more frequently with late oseltamivir. In the same way, a Spanish study of ICU patients showed that ICU length of stay, days of mechanical ventilation and mortality were reduced in patients receiving early treatment versus late treatment with oseltamivir. 13 These reports do not give comparisons with flu patients without antiviral treatment.