In order to assess the degree to which the selected SNPs and the positivity of GM correlated, we also performed lineal regression analysis. In the whole population, 3784 assays were performed in duplicate and 531 were considered as positive (14.03%). We found a significantly higher percentage of positive GM among patients carrying the Dectin-1 rs3901533_T allele and among those patients bearing the Dectin-1 rs7309123_G/G genotype suggesting a role of these polymorphisms in determining a defective recognition and clearance of Aspergillus conidia (Figure 1 ). No correlation was observed for the polymorphisms within DC-SIGN that were associated with the infection.