Design of Entry Inhibitor Peptides www.plosntds.org replication and assembly compartments. The HIV entry inhibitor T-20 (Fuzeon) is a peptide, and in the context of a chronic infection, repeated life-long injections are problematic. DENV is an acute infection and most severe DENV infections require intravenous fluid support, facilitating delivery of anti-DENV peptides by this route.