Results: Immunhistochemically, tumour cells showed immunreactivity for S-100, Vimentin, HMB-45 and Melan-A(MART-1). Tumour cells were negative for CD-20, CD-3, CD-138, CD-56, SMA, Pan-CK and Desmin. Submandibulary lymph node metastasis was observed in one patient. This patient has undergone chemotherapy of temozolomide and 23 cures of regional radiotherapy. For the other patient, there were no metastasis detected by PET-CT. Conclusion: Sinonasal malign melanoma is a rare malignacy, but this entity could be kept in mind to avoid missdiagnosis with other tumors sharing similar morphology. Objective: Significant changes in the voice occur after 50 years. Vocal quality is dependent on the vocal fold (VF) tissue biomechanics that derive from the extracellular matrix composition and organization. We studied muscularlamina propria interface of human VF in the aging. Method: Two authors evaluated density of vessels and the thickness of the deep and muscle layer by HE and IHC (collagenIV) with semiquantitative score. These data were validated by point-counting morphometric method.