Accumulation of AMD AMD and DEA concentrations in rat serum and liver homogenates were determined at various times after LPS administration (Figs. 6A-D). From 2 to 10 h after LPS or saline administration (i.e., 18-28 h after AMD administration), the serum and tissue concentrations of AMD and DEA were unaffected by LPS cotreatment. The average serum concentrations of AMD and DEA were 1100 and 128 ng/ml, respectively; and the average liver concentrations of AMD and DEA were 157 and 53 ng/mg protein, respectively.