Non-lupus "full-house" nephropathy in Serbian population in last six years J. Vjestica * , S. Cirovic, S. Tatic, R. Naumovic, S. Simic-Ogrizovic, J. Markovic-Lipkovski * Inst. for Pathology, Medical Faculty, Belgrade, Serbia Diffuse glomerular and sometimes focal mesangial staining of immune complex depositas (IgA, IgG, IgM, C3, and C1q), also known as "full-house" pattern commonly indicates lupus nephritis. However, some non-lupus nephropathy also can be present with a "full-house" immunofluorescence pattern, mimicking lupus nephritis. The aim of this study was to define the clinicopathological spectrum of originally non-lupus "fullhouse" nephropathy. Biopsies from January 2005 till December 2011 were analyzed in order to identify all renal biopsies cases showing "full-house" pattern. The study included 192 "full-house" renal biopsy diagnosiss. From all analyzed cases 117 (60 %) had lupus nephritis expressing "full-house" pattern and 75 (40 %) cases had non-lupus "full-house" nephropathy. In the absence of clinical and/or serological evidence of systemic lupus erythematosus (SLE), at the time of renal biopsy, in 36 cases diagnose was membranous glomerulonephritis (GN), than 11 mesangioproliferative GN, 9 membranoproliferative GN, 7 IgA nephropathy, 6 rapidly-progressive GN and 6 membranous/membranoproliferative GN cases. Nonlupus "full-house" nephropathy is present in broad spectrum of different types of GN, predominantly in cases of membranous GN. The possibility of "full-house" nephropathy preceding the emergence of overt SLE remained to be clarified. Objective: Although the renoprotective effects of prostacyclin have been demonstrated in many studies, the protection mechanisms of prostacyclin in chronic kidney disease, especially at the terminal stage, are still remained unclear. In the present study, we performed pathological and pathphysiological analyses of prostacyclin renoprotective effects using a stable prostacyclin analogue, beraprost sodium, in the disease kidney of anti-GBM glomerulonephritis (GN) rats. Method: Beraprost was administrated from 2 weeks after induction of GN. The condition of renal microvascular network and localization of apoptotic cells were examined using renal vascular corrosion casts, immunostainings and TUNEL-staining. The intracellular apoptotic signaling pathway was analyzed by Western blot and qPCR. Results: In the kidney of beraprost-treated rat, significantly high density of renal microvascular network was maintained, and apoptosis of vascular endothelial cells was suppressed even at the terminal stage of anti-GBM GN. Pathophysiological analyses revealed that transcriptional and post-translational modifications of Bcl2 and XIAP, which were anti-apoptotic proteins in mitochondria dependent apoptotic pathway, were occurred in the kidney of beraprost-treated rat. Conclusion: These results suggested that prostacyclin protects renal vascular network by inhibiting mitochondria dependent endothelial apoptosis, and it play an important role for preservation of renal function in the chronic kidney disease. Wednesday, 12 September 2012, 09.30 -10.30 Objective: Although villous adenomas commonly occur in the gastrointestinal tract villous adenomas of the urinary tract, including the bladder, are infrequently encountered. Method: We report a case of urinary bladder villous adenoma in a 72-year-old man. The patient was undergone cystoprostatectomy because of diagnosis infiltrative urothelial carcinoma in the transurethral resection of bladder. Results: Histopathological examination of cystoprostatectomy specimen there was no urothelial carcinoma. A 2,5 cm polypoid mass was seen at the dome of the urinary bladder. Histopathology confirmed that this tumor was a villous adenoma with a polypoid growth of the glandular epithelium consisting of small tubular glands, dilated cystic glands or papillary fronds lined by a columnar epithelium. The glandular epithelial cells displayed mild nuclear atypia and nuclear pseudostratification with some mucus cells admixed. The patient was diagnosed with a rare case of villous adenoma of the bladder. Over the past 5 months of follow up, the patient is alive and no metastasis. Conclusion: Patients with isolated villous adenomas in the urinary bladder have an excellent prognosis and surgical resection is curative. However, it is uncertain whether an untreated lesion might eventually develop into an adenocarcinoma. Therefore, close follow up is recommended because of the possibility that this condition might be premalignant.