GLEaM has been under continuous development since 2005 and during these years it has been used: to assess the role of short-range and long-range mobility in epidemic spread [30, 31, 6] ; to retrospectively analyze the SARS outbreak of 2002-2003 in order to investigate the predictive power of the model [22] ; to explore global health strategies for controlling an emerging influenza pandemic with pharmaceutical interventions under logistical constraints [21] ; and more recently to estimate the seasonal transmission potential of the 2009 H1N1 influenza pandemic during the early phase of the outbreak to provide predictions for the activity peaks in the Northern Hemisphere [3, 32] .