BRCA2 -(Breast cancer 2, early onset). Another gene with positive correlations is BRCA2 (Breast cancer 2, early onset), probe G_193736, with Pearson correlation of 0.8161 and Spearman correlation 0.7333). While the loss of BRCA2 function and its consequences in prostate cancer is being reconsidered [50, 51, 52, 53] , BRCA2 is generally regarded as a ''tumor suppressor'', with an established role in maintaining genomic stability via its function in the homologous recombination pathway for double-strand DNA repair. This result is supporting its proposed function. Loss of BRCA2 function is thus a warning sign of the existence of error prone cell processes. In prostate cancer BRCA2 has been associated to promotion of invasion through upregulation of MMP9 [54] . BRCA2 loss of function due to mutations is linked to poor survival in prostate cancer [55] and rare germline mutations have been associated with early-onset of prostate cancer [56] .