Compared to VM, 84 protein spots were found to be differentially expressed in FM (t-test; p,0.05). After FDR (Benjamini-Hochberg) and Bonferroni correction 10 and 3 protein spots (out of 84) remained significant, respectively (Table  S1 .3). Out of 84, MS IDs for 43 protein spots were obtained in MALDI-TOF/TOF MS analysis, which indicated differential expressions of 13 proteins in FM compared to VM. Among those 13 differentially expressed proteins, 5 proteins (interleukin-17E precursor, serum amyloid A, ficolin 3 precursor, alpha-1antitrypsin and Ig kappa chain C region) were up-regulated while the remaining 8 proteins (alpha-2-HS-glycoprotein, apolipoprotein E, serotransferrin precursor, alpha-1-antichymotrypsin, leucinerich alpha-2-glycoprotein, AMBP protein, vitamin D-binding protein and haptoglobin) exhibited reduced expression level in Pf infected patients (Table S3 .4).