The number of possibilities for all the cells put together and the effective information can be calculated by using permutation and combination formula similarly, but the equation is very long and the explanation can be quite complex. It is better to separate the effective information directly to three parts and calculate separately: first, the information to encode all the proteins (I 1 ); secondly, the information to produce all the differentiated cells (I 2 ); and finally, the information to construct the spatial structures (I 3 ).