The resulting analysis will still be based on major simplifications in respect to all the spatial and other social constructs that govern disease transmission, but less so than those based on the very simplest assumption of free, homogeneous mixing. In this context, it should be stated that even in the best, most robustly parameterised microsimulations, gross approximations are made in describing the fabulously complex web of human behaviour, and even they are only attempts to characterise the statistical properties of the system as a whole. Extensive effort is, and should continue to be, spent on identifying the conditions where different types of simplification (household models, static network models, spatial metapopulation models…) can and can't be justified, and in developing analytical approximations to describe disease transmission within such simplified structures.