Although proteomics analysis of active multiple sclerosis lesions may be a straightforward approach to study the processes involved in MScl disease pathways [6] , this is very difficult to perform in living individuals. In most cases the pathology of the disease can only be investigated in post-mortem material, which quite frequently represents the end-stage of the disease. The study of CSF taken during disease appears a good alternative. CSF is in close contact with the CNS parenchyma and collects the products of the inflammatory and neurodegenerative processes of MScl activity.