We further compared the genotype distribution of FCGR2A, FCGR3A, FCGR3B and FCGR2B between the 58 patients without predisposing condition and controls. Similar to results from the overall patient group, associations were also found between FCGR2B 232I/T genotypes and cryptococcal meningitis based on dominant and over-dominant model. Specifically, FCGR2B 232I/I genotype was also more frequently detected (OR = 1.958, 95% CI [1.05-3.66]; P = 0.033), and FCGR2B 232I/T genotype was also less frequently detected (OR = 0.467, 95% CI [0.24-0.91]; P = 0.023) in patients without predisposing factor than in controls. For the genotype distribution of other polymorphisms (FCGR2A 131H/R, FCGR3A 158 F/V and FCGR3B NA1/NA2), there was also no significant difference between patients and controls.