In this report, McCormack and colleagues retrospectively reviewed outcomes of 61 patients at their institution who underwent nonmyeloablative SCT and evaluated the impact of pretransplant consolidation chemotherapy on outcome. All patients had AML in CR1 at time of transplant and received either HLA matched sibling (n 5 18), cord blood (n 5 42) or unrelated (n 5 1) donor grafts. Of these patients, 26 received pretransplant consolidation (73% received 1 round; range 1-3) and 35 received none: 58% and 40% in each group respectively had high-risk cytogenetics. In univariate analysis, exposure to pre-SCT consolidation therapy had no impact on 2 year OS or relapse rates and did not increase treatment related mortality rates (See Table I ). In multivariate analysis (variables tested: comorbidity score, number of induction cycles to achieve CR, high risk cytogenetics) exposure to consolidation therapy still had no effect on relapse. The only variable significantly associated with treatment related mortality was comorbidity score.