Colombia, it is the third leading cause of cardiovascular death. Cardiac rehabilitation programs aimed at individuals with CHF are designed to decrease morbidity and mortality and improve quality of life (QOL). Little data is available on the impact of cardiac rehabilitation programs on QOL in CHF patients in Colombia. The SF-36, a self-report instrument validated in Spanish with 8 subscales and a question regarding Health Expectations, was used to measure QOL in 35 CHF patients participating in a cardiac rehabilitation program at St. Vincent de Paul Hospital in Medellín, Colombia at baseline, 3-month, and 6-month follow-ups. The rehabilitation program consisted of 12-session treatment protocol including exercise, occupational therapy, and psycho-education. One-way repeated measures ANOVAs were conducted for each QOL sub-scale. Results indicated that CHF patients participating in cardiac rehabilitation significantly improved their Physical Performance sub-scale scores and Health Expectations score over time (p<0.001 and p<0.01 respectively). Cardiac rehabilitation CHF patients also tended to have improved General Health subscale scores and Physical Functioning sub-scale scores over time (p=0.05 and p=0.09 respectively). Scores on the remaining SF-36 sub-scales (Pain, Emotional Performance, Social Functioning, Mental Health, and Vitality) did not vary over time (p = NS). A cardiac rehabilitation directed at CHF patients appears to improve specific physical health-related domains of QOL, although future research involving a control group would strengthen these Results: