A well-trained radiologist [with more than nine years experience (DMJ)] carefully examined the complete scan (i.e., 60 CTs) and labeled the lung regions as normal and abnormal (with TIB patterns) (see Fig. 1 ). As many regions as possible showing abnormal lung tissues from 39 HPIV patients were labeled (see Table I for details of the number of regions used in the experiments). Those 39 patients do not include only TIB opacities, but also GGO, nodules, consolidations, and linear thickening such that only TIB regions are labeled in training step. Note also that the control group consisting of 21 subjects with no observed lung abnormalities was constructed and lung tissues pertaining to this group were labeled carefully.