Association Analyses of TNF, LTA, TNFRSF1A and TNFRSF1B SNPs with Severe Sepsis Outcomes We next investigated the association between all tested SNPs and 30-day mortality. The overall 30-day mortality rate among severe sepsis patients was 36.1%. We compared the allele and genotype distributions of all tested SNPs between survivors and non survivors of severe sepsis patients. No association was observed between TNF, LTA, TNFRSF1A and TNFRSF1B variants and 30-day mortality in the severe sepsis cohort in either the unadjusted or adjusted models (Table 4 ).