FIG. 8. SG, anisomycin, and ricin but not lipopolysaccharide induce rRNA cleavage patterns identical to DON in RAW 264.7. Cells were treated with DON (1000 ng/ml), SG (10 ng/ml), anisomycin (25 ng/ml), ricin (300 ng/ml), and lipopolysaccharide (10 lg/ml) for 6 h. RNAs were purified and analyzed by capillary electrophoresis. Results are representative of three separate experiments. 388 HE, ZHOU, AND PESTKA embedded rRNA to constitutive and inducible RNases, resulting in the highly selective cleavage observed here.