We need to go back to basics to explain these evolving concepts and resolve this apparent paradox. The phrase ''karyotypic entropy'' has been used in the past to define what is actually a divergence from the normal chromosome structure and it genomic organization. This denomination has also been employed by several authors, notably [601] , but it has also been used in at least two other publications [620, 621] . These works have in common the use of this term to refer to a ''disorder'', fuelled by the undergraduate textbooks indoctrination of associating increase of entropy in natural spontaneous processes with the increase of ''observed disorder'' in the system. We propose that the use of a natural measure of divergence, the Jensen-Shannon divergence, could not only be a more formal, but also more appropriate modelling approach. As such, we propose to introduce the term 'karyotypic divergence' or 'karyotypic Jensen-Shannon divergence' to replace this concept and to avoid a subjective approach.