One might intuitively object that, rather than test predicted interactions, a better strategy would focus on the "novel" areas of the interactome that have never before been suggested by any species or data set. The problem with such an approach is that it would very quickly produce an interactome map with a very high error rate. Conversely, the rationale behind the Thresholding and Prediction strategies is that one should first clean up the map by validating predicted interactions using real experiments, and only then resort to testing random protein pairs in pools.