The spatial clustering of the HIV epidemic in the rural areas of the Odessa region showed a divergence in the spatial distribution between IDU and sexually transmitted HIV. We believe this finding may indicate the generalization tendencies of HIV epidemic. Our hypothesis has been supported by other epidemiological characteristics, such as: increase in number of sexual HIV cases and their proportion in the total number of HIV cases; increase in proportion of Radas reporting sexually acquired HIV cases but not IDU-acquired HIV cases; increase in the proportion of sexual HIV cases reported in these Radas; HIV seroprevalence among pregnant women in the region accounted in average to 0.9Á1.1%.