Objective: Lung cancer represents major problem in oncology as the incidence and mortality is high (Parkin et al., 2005) . Molecular studies could reveal additional targets for intervention or prognostic evaluation. However, the published data are controversial (Renouf et al.,2009; Leung et al.,2010; Maraz et al.,2011; Ko et al.,2011) . Method: Consecutive lung cancer cases (278) were retrieved by retrospective archive search. The diagnostics has been performed systematically in accordance with WHO classification (Travis et al.,2000) . The expression of CD44, E-Cadherin and Bcl-2 was analysed by immunohistochemistry and evaluated semiquantitatively. Results: The intensity of Bcl-2 expression was highest in small cell cancer, reaching the mean value 2.25. No or very low Bcl-2 expression was found in adenocarcinoma, carcinoid and squamous cell cancer. The membranous expression of E-Cadherin showed significantly higher mean intensity in adenocarcinoma (1.93) and carcinoid (1.90) than in small cell cancer (0.14) and squamous cell cancer (0.85). Cytoplasmic E-cadherin expression was observed in small cell cancer. CD44 expression was widespread and frequent in non-small cell lung cancer. Conclusion: The main histological types of lung cancer show different immunophenotype. Bcl-2 expression is found in small cell cancer. The expression of E-Cadherin is characteristic in adenocarcinoma and carcinoid. CD44 is expressed in non-small cell lung cancer.