Polyamines are generally involved in growth and differentiation [64] [65] [66] [67] within the cell and their analogs are also used as anticancer agents, antiparasitic agents, antidiarrhoeals, anti-HIV agents, metal chelators, and gene delivery agents. Since the inhibition of the initial polyamine biosynthesis enzyme, ornithine decarboxylase, by DL-α-difluoromethylornithine (DFMO) is toxic to African trypanosomes cells, [68, 69] polyamines can become a promising anti-trypanosomal compound.