Family Y had affected members across three generations and three genotypes/subgenotypes. In 2006, the grandfather of family Y (Y1) was infected with genotype C2 while grandmother (Y1W) had mixed infections of CD1 and C2. Mother (Y2W) and granddaughter (Y3F) were infected with the CD1 recombinant. Father (Y2) had triplicate infections of genotype C2, D1 and CD recombinant. Grandson's (Y3M) serum was unavailable. In 2007, the grandfather (Y1) and mother (Y2W) had HBV DNA levels below the detection limit while the grandmother (Y1W) and granddaughter (Y3F) had genotype CD1. Father (Y2) and grandson (Y3M) had genotype D1.