Method: A 48-year-old man was admitted with a mass of the right preauricular area. The mass had been enlarging steadily for the past 7 months. Computed tomography (CT) of the neck revealed 4×3×3 cm contrast enhancing solid mass with irregular borders at the right parotid region. Thorax CT, abdominal and thyroid ultrasonography were unremarkable. As the aspiration cytology was malignant right parotidectomy and right cervical lymphadenectomy was performed. Results: Histopathological examination showed a mixture of ducts, nests and cords of cells often embedded in a desmoplastic stroma with comedonecrosis of some ductal structures. The tumor cells were polygonal with vesicular nuclei, prominent nucleoli and eosinophilic, oncocytic cytoplasm. The tumor margins were lobulated and irregular with perineural invasion. Mucin stains were negative. We noted high proliferative index and cerbB2 overexpression. The tumor was classified as a salivary duct carcinoma, oncocytic variant of parotid gland. The resection margins were negative and the lymph nodes were reactive. Conclusion: As high proliferative index and cerbB2 overexpression are predictive factors, close clinical follow up is recommended for the risk of local recurrences and metastasis.