Prevention of HAPE, as well as its associated symptoms and signs, is important to reduce its incidence among those ascending to high altitude. To achieve this, the following factors are particularly important. (1) Maintain body warmth with appropriate insulation and avoid upper respiratory tract infection. Several days before ascending to high altitude, bathing should be avoided to reduce exposure to cold temperatures. (2) Avoid fatigue. Physical activity at high altitude should be performed at an intensity of no more than 60-80% of that at sea level and duration of activity should be <6 h. Similarly, the body must be given sufficient time to rest both before and during the time at high altitude.