Cancer is still one of the most frequent causes of death in Western countries, and understanding its molecular causes as well as establishing appropriate animal model systems for the development of new treatment strategies is very important. Fragiskos Kolisis reported on the setting up of an infrastructure for a systems biology approach to carcinogenesis and aging (Chatziioannou et al. 2009 ). Understanding proteasome function and dysfunction as well as studying the alterations of the genome and proteome that account for different cancer phenotypes in a mouse skin carcinogenesis model are among the research goals. Javier Santos used GRPs to identify genetic traits for the susceptibility to radiation-induced thymic lymphomas in interspecific recombinant congenic and consomic mouse strains (Santos et al. 2009 ). Frank Lammert developed assay systems to determine genetic causes of liver fibrosis and inflammatory liver carcinogens in the BXD mouse recombinant congenic GRP (Weber et al. 2008) .