Our finding of lower hOCT1 mRNA expression in total LEU from IMA naïve de novo CML patients that quickly reached the expression levels of healthy volunteers is in accordance with observations from Bazeos et al. [6] . However, the authors from that study assumed that this finding was related to the achievement of a complete cytogenetic response. According to our findings, the increase in hOCT1 mRNA expression after the start of IMA treatment was not caused by the suppression of inhibitory effects of the BCR/ABL oncogene, as suggested by Bazeos et al., but rather was due to a significant effect of the lower hOCT1 mRNA expression in immature myeloid cells (mostly CML tumor cells), which rapidly disappeared from the PB within the first month of IMA therapy.