AMACR, Cyclin G2, CDK4 and CDK7. Other probes that also have high negative correlations with the Shannon Normalized Entropy correspond to CCNG2 (Cyclin G2) CR598707, CDK4 (Cyclin-dependent kinase 4), CDK7 (Cyclin-dependent kinase 7, TFIIH basal transcription factor complex kinase subunit) [339] , and AMACR (Alpha-methylacyl-CoA racemase), an ''obscure metabolic enzyme (that has taken) centre stage'' [340] as judged by the extraordinary convergence to this biomarker in prostate. We believe that our result is an important finding. AMACR was not judged of importance according to the methodology used in [332] and it was barely cited in that manuscript. Here we present results, from an unifying biological and informational principle, which allows (using Ref. [332] 's own data) the identification of the most central current biomarker with a truly compelling body of support in independent studies [ [490, 491] . Knockdown of BRCA1 results in the accumulation of multinucleated cells, indicating that BRCA1 regulates gene expression of an orderly progression during mitosis [492] , preserving chromosomal stability [490] . BRCA1 showed decreased expression in a study involving immortalized prostate epithelial cells before and after their conversion to tumorigenicity [493] . Lack of BRCA1 function may impair activation of STAT3 [494] . Inactivation of TP53 by somatic mutations is also associated to the panel of disruptions which are common for this ''tumor suppressor'' [113] . One possible mechanism for gene silencing is CpG island methylation. Rabiau et al.show in [495] that BRCA1, RASSF1, GSTP1 and EPHB2 promoter methylation is common in prostate biopsy samples. Mannicia et al. suggest that the mitochondrial localization of BRCA1 proteins may be a significant factor in regulating the mitochondrial DNA damage [5] .