Breast cancer management has been evolving toward minimally invasive approaches. With the improvements in imaging techniques that have allowed the earlier detection of smaller breast cancers and the desire for improvements in cosmetic outcome, a number of minimally invasive techniques for the treatment of early stage breast cancers are being investigated. Breast conservation therapy has become the treatment standard for early-stage breast cancer. The next challenge is to treat primary tumors without surgery. For this purpose, several new minimally invasive procedures, including radiofrequency ablation, cryotherapy, interstitial laser ablation, microwave ablation, focused ultrasound ablation and percutaneous tumor excision, are currently under development and may offer effective tumor management and provide treatment options that are psychologically and cosmetically more acceptable to the patients than are traditional surgical therapies. In this course, we give an overview of minimally invasive approaches for the therapeutic management of benign breast lumps and early-stage breast cancer. It is cautiously optimistic that these therapies can be used as a routine adjunct in the treatment of selected breast cancers. The challenge will lie in the ability to identify multifocal disease and in situ carcinoma as well as to ensure complete and effective eradication of the breast cancer. Actually, breast conserving surgery remains the standard of care for breast malignancies and additional research is needed to determine the efficacy of these techniques when they are used as the sole therapy and to determine the long-term local recurrence rates and survival associated with these treatment strategies. Sunday Several cardiomyopathies will be reviewed such as ischaemic cardiomyopathy and hypertropic cardiomyopathy, including their appearance on regular chest CT. Several valve disease entities such as mitral valve stenosis and prolapse, heavily calcified aortic valve disease/stenosis, bicuspid aortic valves and infective endocarditis will also be reviewed on regular chest CT. Several different types of cardiac shunts such as ASD, VSD, PAPVR-with sinus venosus ASD and interatrial septal aneurysm will also be discussed and their appearance evaluated on routine chest CT. A spectrum of coronary anomalies/fistulas that may be detected on standard chest CT will be discussed. The talk will also review the typical pulmonary changes seen in heart failure, both in the lung parenchyma and the heart and its vessels. Finally, the cardiopulmonary manifestations of smoking will be discussed including the appearances and implications of coronary artery disease. Learning Objectives: