AICD regulates the transcription of several target genes, some better characterized than others (Beckett et al., 2012; Pardossi-Piquard and Checler, 2012) . The most well documented gene upregulated by AICD is of the amyloid-degrading enzyme neprilysin (Pardossi-Piquard et al., 2005; Belyaev et al., 2009) . However, there is also evidence that APP itself (von Rotz et al., 2004) , BACE1 (von Rotz et al., 2004) , GSK-3β (Kim et al., 2003) and aquaporin-1 (Huysseune et al., 2009) can be regulated by AICD. In addition to APP, regulation of the GSK-3β can be considered as a link between AICD and AD pathology especially taking into account the data on elevated levels of AICD in the brain of AD patients (Ghosal et al., 2009) . Moreover, the ability of AICD to regulate expression of APP and BACE1 suggests a feedback mechanism of its own regulation by proteolytic processing of its precursor (Grimm et al., 2012a) .