Results: According to clinical history, GBLs consisted of 146 primary and four secondary GBLs. However, EGFR(+)/ p53(−) immunohistochemical features of P-GBL consisted 41.3 % and EGFR(−)/p53(+) immunohistochemical features of S-GBL consisted 28.6 % among 150 cases. EGFR(+)/p53 (+) was noted in 20.6 % and EGFR(−)/p53(−) in 9.3 %. Immunohistochemical expression of IDH-1 was noted in 14 cases (9.7 %) out of 144 cases. Expression of IDH-1 and EGFR(−)/p53(+) showed positive correlations with young age. Characteristic features of S-GBL were noted in 3.5 % of clinically P-GBL. Conclusion: We analyzed immunohistochemical subtypes of Korean glioblastomas. Combination of EGFR and p53 was unsatisfactory but combination of EGFR, p53 and IDH-1 can be a good tool for immunohistochemical subtyping of glioblastomas. (also known as erbB-2) is a 185-kD transmembrane glycoprotein with tyrosine kinase activity. HER2 is expressed in some human malignancies and can be a potential target for therapeutic intervention with selective inhibitors. There are only a few studies on the relationship between meningioma and HER2 expression, and the results are different as well. The aim of this study was to determine this relationship. Method: Seventy-two paraffin blocks of meningioma were selected randomly and immunohistochemical staining was then performed for each specimen.