Another study examining the effects of antiviral treatment and prophylaxis, home quarantine and social distancing based on a community of a million population with the assumption that pandemic influenza was introduced by an undetected airline passenger, found that if a pandemic Ro was 3.0, individual interventions would result in increased transmission while combination measures may break community transmission [25] . This was similarly shown by Ciofi and colleagues for a pandemic with Ro of 2.0 [23] . A deterministic compartmental model evaluating the effects of antiviral treatment and prophylaxis, vaccination, case isolation and air traffic reduction globally demonstrated that individual strategies such as case isolation and air travel restrictions may result in higher peak AR even though overall AR could be reduced [26] .