In this present study, we examined two independent GWAS data sets, and then performed a meta-analysis by combining the data sets in order to discover authentic genetic markers for POAG, HPG, or NPG. We succeeded in identifying some significant variants in the CDKN2B-AS1 locus using a Japanese population, as that locus has also been shown to be significantly associated with POAG in Caucasians [14] . Moreover, the variants that passed the Bonferroni correction seemed to be associated with POAG and POAG/NPG, thus suggesting that the locus potentially affects the NPG, rather than the HPG, subtype of POAG. Although we still need to confirm our findings by use of a larger HPG cohort in order to increase the statistical power, the variants identified in this study could be associated specifically with the vulnerability of the optic nerve to IOP, thus enabling us to investigate the etiology of glaucoma.