ADA -(Adenosine deaminase) and DPP4/CD26 (Dipeptidylpeptidase 4, CD26, adenosine deaminase complexing protein 2). A link between TP63 and ADA has already been reported in the literature. ADA is a gene involved in cell division and proliferatation [120] and it has been suggested to have a regulatory role in dendritic cell innate immune responses [121] .Translational modification is also a function of p63. Sbisa et al. have proved that ADA is a direct target of isoforms of p63, which is an important discovery as ADA has two TP53 binding sites, leading to a complex metabolic balance due to the different relationships between this trio and p21 yet to be completely elicitated [120, 122] . Several studies indicate elevation of adenosine deaminase levels in sera of breast [123] , head and neck [124] , colorectal [125] , acute lymphoblastic leukaemia [126] and laryngeal cancers [127] .