Objective: A 25-year old woman with a 2-year history of a multifocal lesion occupying the cerebellum who periodically received cortisol and etoposide as it was considered tumor-forming multiple sclerosis. Method: Two years after initial clinical diagnosis a stereotactic biopsy was performed. Immunohistochemistry and in situ hybridization were performed on the tissue sample. Results: The perivascular (Virchow-Robin) space of microvessels was occupied by middle sized lymphocytes with blastic chromatin and scant cytoplasm. The neoplastic cells were negative for: 1. B-cell markers: CD19, CD22, CD20, CD79a, Pax-5, 2. Myelogenous differentiation antigens: MPO, CD13, CD33, 3. Plasmacytoid dendritic differentiation antigens: CD123, TCL1, 4. Blastic cells markers: CD34, CD117 5. T-cell markers: CD3, CD5 with restricted expression of CD2 and CD7 in a few cells, 6. Cytotoxic enzymes TIA-1, Granzyme-B and perforin. All cells expressed intensely CD56 and TdT and some of them CD16. In situ hybridization for EBV virus (EBERS) was negative. PCR analysis: T-cell receptor and immunoglobulin genes were in germ line. Bone marrow was negative. Objective: Lymphomas constitute 33,65 cases on 100 000 inhabitants annually, its frequency grows. Method: This work presents epidemiological, morphological analysis of nodal/exstranodal lymphomas. Analysis of data from Izhevsk cancer center during 2009-2011 was carried out. Results: Lymphoma appeared in 2.94 % among first diagnosed malignant tumors. The panel of monoclonal antibodies was used for tumor immunophenotype identification. Nodal lymphomas presented 183 cases: 55 -Hodgkin lymphoma (HL), 128non-Hodgkin lymphoma (NHL). Exstranodal lymphomas presented 111 cases, various variants of NHL were more frequent. Small lymphocyte lymphoma -37, diffuse large B-cell lymphoma (DLBCL) -36, follicle center lymphoma -18, mantle cell lymphoma -8 were frequent among nodal lymphomas. T-cellular NHL presented 16 cases (6 -peripheral T-cell lymphoma, 7 -angioimmunoblastic Tcell lymphoma). Among other organs of lymphatic system lymphomas appeared in tonsils (19), thymus (15) and spleen (9). Exstranodal NHL were registered in stomach (25), rarely in other organs -testis (7), central nervous system (3), nose (3), breast (3). As rule DLBCL was more frequent (36). Conclusion: Results coincide with data on lymphoma's frequency and morphological characteristic in other regions.