Annotated ELM instances serve as representative examples of the respective ELM class. They are also invaluable for the computational analysis and classification of motifs (15) . Therefore, special emphasis has been put on the curation of more than 500 novel ELM instances (in 40 different classes) by scanning and annotating more than 400 articles. The number of protein databank (PDB) entries annotated have been increased to 195 (Table 1 ), meaning that for 10% of all instances there is a 3D Figure 1 . ELM start page. The user can submit a query sequence to the motif detection pipeline either as UniProt accession number or in FASTA format. Filtering criteria such as taxonomic range or cellular compartment should be activated to limit the resulting list of SLiM instances.