While the evolution of rhinoviruses has been well characterized at the serotype or species level [13, 28, 29, 30, 31, 32] , little is known about the diversity generated during the course of a natural human infection. Several studies have investigated the genomic variability of enteroviruses and vaccine-derived polioviruses during chronic infections in immunocompromised patients, but there is no such report for rhinoviruses [33, 34, 35, 36] .