We then compared the results from two different search strategies. In the first, an emulation of a PubMed search, we only examined the MeSH terms and the title for the letter. Our second approach included a search of the full text of the letters in addition to the title. Using these two strategies, we were able to determine the 'earliest' letter in these two journals for a given drug/ADE pair. We compared this date against the date of the citation referenced by MicroMedex to determine which search method provided the earliest detection.