Data from observational studies in humans and interventional studies in animals, suggests that the course of influenza may be favorably influenced by relatively inexpensive and readily available agents, such as rosuvastatin, that are not classically considered to be treatments for influenza. These agents are attractive as adjuvant treatments amidst emerging reports of oseltamivir resistance and threatened drug supply shortages. However, the ability to administer and test the efficacy of an adjuvant agent as a treatment for severe H1N1 infection remains to be established.