M/F male/female, IS Injection site, aPTT activated partial thromboplastin time, CK creatine kinase constant, with minor increases between days 0 and 85. Apart from scheduled fasting days prior to procedures, the individual food consumption was generally 75-100 % of the daily ration across groups. On days when animals were sedated, the consumption was typically 25-50 % of the daily ration, and occasionally 0 % (on days 1 and 57 for nearly all females of groups 4-6, and on day 84 for two Rouvax-treated males). These fasting periods had no impact on body weights and were similar across control and vaccine groups, and thus considered to be unrelated to immunization. Mean rectal temperatures of groups of vaccinated males were not significantly different from those of the control groups at all time points. For females, the sporadically noted statistical differences between groups remained within the ranges commonly recorded in animals of this age housed in similar experimental conditions. Consequently, no treatment-related effects on body temperature were observed in the study.