In the first 1-5 d of study, the serum CRP levels of both the patients with severe H1N1 and the patients with moderate H1N1 were significantly higher than that of the control group (P < 0.01; Figure 1f ). Correlation analysis of the CD4 + , CD8 + T, CD4 + CD25 + , CD19 + B, and NK cells with CRP was conducted and the results indicate that the various lymphocyte subgroups had no significant correlations with CRP.