CDKN2D (Cyclin-dependent kinase inhibitor 2D, p19, inhibits CDK4). One of the genes that has strong positive correlations is CDKN2D, (Cyclin-dependent kinase inhibitor 2D, p19, inhibits CDK4) (Pearson correlation of 0.7543, Spearman correlation 0.6833), probe G_145503. A gene that shows a positive correlation with the divergence of a metastasis profile indicates a gene that has a putative reduced expression on these samples. CDKN2D is a known regulator of cell growth regulator and controls cell cycle G1 progression [46, 47] . Loss of CDKN2D in cancer cells is one event which is generally associated to a more malignant phenotype.