In 1965, Egeberg et al (14) firstly introduced the concept of thrombophilia based on discovering a family with an autosomal dominant inheritance disease whose members manifested with repeatedly onset of DVT due to depletion of antithrombin III. Since then, many reports have considered that genetic gene mutation was one of the major factors in the pathogenesis of VTE (15) , but there has been a lack of sufficient genetic etiology evidence in many clinical PE patients.