In this report, we studied the influence of the tagging and potentially functional polymorphisms of DC-SIGN, Dectin-1, Dectin-2, CCL2/MCP-1 and CCR2 in susceptibility to IPA infection in a Spanish population. Polymorphisms in these genes have been reported to influence a number of infectious diseases including HIV-1 [47] [48] [49] , HTLV-1 [50] , CMV [51] , Tuberculosis [52] [53] [54] [55] , HCV [56, 57] , HBV [58] , Dengue [35] and SARS [59] among others, revealing their potential role in host defense against pathogens.