The dose is always the same (24 µg/kg/hour), regardless of the type of organ failure or the degree of sepsis severity. In addition, the 96-hour window of treatment is always the same so that interruptions of treatment are made up at the end to maintain a total of 96 hours of treatment. Twenty-eight-day survival in patients treated with drotrecogin alfa (activated) or placebo: all-cause mortality. 