Influenza A/H1N1 pandemic represents a global health issue, as it was estimated to be the direct cause of over 600 million respiratory infections and over 50 million hospitalizations, until August 10 th , when WHO announced that H1N1 was in post-pandemic period [6]. Immunosupression is a well-defined risk factor for worse outcome in H1N1 disease. ARDS and secondary bacterial super-infections, leading to septic shock and multiple organ failure are considered to be the primary causes of death [4, 7] . However, primary viral septic shock, especially by influenza, is rarely reported in the literature [8] [9] [10] [11] .