Pretreatment with physostigmine could help prevent the CNS consequences, but could also cause its own CNS toxicity. In animal studies of soman intoxication, ketamine in combination with atropine and benzodiazepines proved effective in stopping seizure, reducing brain damage, and increasing survival [108] The weakness usually resolves within 5 to 18 days. Ventilatory support in survivors is often required for several days or weeks. Table 4 provides an overview of the recommended therapy for casualties of nerve agents.