Paraspeckles [760, 761, 762, 763, 764, 765, 766, 767, 768, 769, 770, 771, 772, 773, 774, 775, 776, 777] are a novel nuclear compartment, of approximately 0.2-1 mm in size, discovered in 2002, by Fox et al. in Dundee Scotland, following the identification of the protein PSPC1 (AF448795) in the nucleolar proteomics project at Lamond's lab which is described well by Fox et al. [777] . Three years later, Fox, Bond and Lamond showed that NONO and PSPC1 form a heterodimer that localizes to paraspeckles in an RNA-dependent manner [773] . Paraspeckles are dynamic structures, observed in numbers that vary between 10 and 20, that seem to control gene expression via retention of RNA in the nucleus [772] . A long noncoding RNA called NEAT1/MEN epsilon/beta [754, 760, 762, 764, 778] , that colocalizes with paraspeckles, seems to be integral to their structure. Depletion of NEAT1 erradicates paraspeckles and a biochemical analysis by Clemson et al indicates that the NEAT1 binds with paraspeckle proteins SFPQ/PSF, P54NRB/NONO and PSPC1. NEAT1 is also known as TncRNA (trophoblast-derived noncoding RNA) [754, 779, 780, 781, 782, 783, 784, 785, 786] and probes for TncRNA exist on this dataset, We have observed in True et al.'s dataset that there exists a high correlation between the Normalized Shannon Entropy with the expression of SFPQ/PSF, P54NRB/NONO, and TncRNA. Overall, this implies that the disruption of the function of the paraspeckles is correlated with the increasing signs of deterioration of normal transcriptomic state of the cells. While a causal relationship still needs to be proved, we admire the mathematical elegance of the Normalized Shannon Entropy of the samples, a global measure of the average expected surprisal of the transcriptome, which in turn has lead us to consider the dysfunction of the smallest nuclear body as a putative biomarker of disease progression. The role of SFPQ/PSF in the control of tumorigenesis is under investigation [787] and the information coming from these studies would need to be integrated with their role, together with P54NRB/NONO and TncRNA, in paraspeckles if we want to achieve a better understanding of these mechanisms.