Objective: Adenomyosis (AM) is a very common gynecological disorder. Despite high incidence of the disease epithelial changes precise developmental events leading to the condition remain controversial. The aim of the study was to investigate and compare epithelium morphologicaly and markers expression of proliferation, apoptosis, invasion and neoangigogenesis in AM foci. Method: This study was done on biopsy samples of uterus taken from 70 women with adenomyosis. Immunohistochemical staining of tissues was performed with antibodies to ApoCas, Ki-67, MMP-2, TIMP-1, claudins 3, 5 (CL3,5), E-cadherin, COX-2, EGFR, VEGF. Results: Four variants of epithelium changes were found in AM foci such as proliferative type, hyperplastic type with and without atypia, and atrophic type. times during 3 years and investigated using routine light microscopy and immunohistochemistry (IHC) to control the treatment response. Results: In the course of progestin treatment the complex endometrial hyperplasia with intraepithelial neoplasia became histologically less complicated and than normal. IHC profiles and Ki-67 expression had the same dynamics. In the youngest patient the unusual gland cell atypia with focal calcification was observed one time and hysterectomy was considered. Conclusion: The study confirms that the repeated curettages with conservative treatment and histological studying can be successfully used in some cases of complex endometrial hyperplasia with intraepithelial neoplasia.