A systematic review about the use of CAM in chronic hepatitis C has been conducted by Coon and Ernst [14] , The authors cited fourteen randomized clinical trials considering the combined use of herbal products and interferon-alfa during antiviral treatment. Although difficulty in extrapolation and interpretation of results because of different methodological limits of the considered studies, the authors found that several herbal products and supplements (vitamin E, thymic extract, zinc, traditional Chinese medicine, Glycyrrhiza glabra, and oxymatrine) could exert potential virological and biochemical effects in the treatment of chronic hepatitis C infection, as a greater clearance of HCV-RNA and normalization of liver enzymes.