Ang II binds with high affinity to two different receptor subtypes-AT1R and AT2R-which are members of the seven-transmembrane-domain G-protein-coupled receptors (GPCR) superfamily, through Gq and Gi, respectively [35] . Whereas the AT1R mediates most of the recognized actions of Ang II, it appears that the AT2R opposes, in part, to the effects mediated by the AT1R. As the AT2R is expressed in adult tissues in smaller amounts than the AT1R, the actions and cell signaling of AT2R have been less well characterized International Journal of Hypertension 3 than those of AT1R [36] [37] [38] . Current knowledge suggests that AT2R stimulation mediates vasodilation, antigrowth, proapoptotic and antiinflammatory effects [39, 40] . Hence, the AT2R can modulate cardiovascular remodeling as well as progression of atherosclerosis.