The most striking results were obtained by the comparison of DENV infected cells in the presence and absence of the FAS inhibitor, C75. It is well established that treatment of cells with this inhibitor disrupts de novo phospholipid biosynthesis [51] . To circumvent this inhibition, the cell redistributes its lipid repertoire to ensure cell survival. However, this redistribution does not support DENV replication. A comparison of the different lipid environments indicated that many of the lipids that were up regulated in DENV infected cells compared to cells treated with C75, were similar to those previously observed when infected cells were compared to mock (uninfected) controls. Therefore, comparison of DENV infected cells to two different controls (uninfected cells and C75 treated infected cells) highlighted the same lipids as being up regulated during an active DENV infection.