Phylogeny. The H10N7 Camargue strain was isolated in embryonated chicken eggs and amplified. Determination of the sequence of the whole genome was performed in order to gain insights into its phylogeny and molecular characteristics. The phylogenetic analysis of four H10N7 Camargue isolates confirmed that they were very closely related to each other and formed a cluster (Figures 1 and S1 ). Analysis of each of the sequences of the 8 viral segments highlighted some shared characteristics (Figures 1 and S1). First, the sequences of all segments were clearly distinct from those of LPAIV strains from the North-American lineage. Second, none were closely related to highly pathogenic viruses (H5N1 or H7N7) that circulated in Europe and Asia. However, the PB2 segment was more closely related to the Asian HP H5N1 cluster than to most of the European LPAIV strains we included in our phylogenetic analysis. This finding suggests an ancient Asian origin of this segment. Third, the sequences of all segments were closely related to Eurasian strains. Interestingly, the most closelyrelated Eurasian strains differed between segments. As an example the LPAIV strain A/mute swan/Hungary/5973/2007 (H7N7) was very closely related to the H10N7 Camargue virus for the N7 segment, but less so for the M segment and belonged to a distant phylogenetic group for the PB2 segment. In the same way, the LPAIV strain A/mallard/Netherlands/9/2005 (H7N7) was closely related to the H10N7 Camargue virus for the M segment, whereas its PB2 segment belonged to a distinct phylogenetic group. African strains that we included in our analysis were part of Eurasian clusters and clearly distinct from American strains. For one of them, A/Pekin duck/South Africa/AI1642/2009 (H10N7) the NS, N7 and H10 sequences were closely related to those of the H10N7 Camargue virus but available sequences of two other segments (NP and M) were clearly distinct. Finally, it is important to note that based on the analysis of partial sequences of the H10 (data not shown) the H10N7 strains that caused human infections in Australia (Genebank accession numbers ADG58106 and ADG58107; Ratnamohan,V.M. and Dwyer, D.E. unpublished) are clearly distinct from the H10N7 Camargue strain. On the contrary Egyptian H10N7 strains that circulated in birds in 2004, i.e. at the time of the detection of two human infections [41] , are relatively closely related to the H10N7 Camargue strain. However, this relatedness is difficult to interpret since the involved nodes are not strongly supported statistically (Figure 1) .