Primary DENV infection is believed to provide lifelong immunity against re-infection with the same serotype [18, 19] . However, humoral immune responses to DENV infection are complex [20] [21] [22] , and may exacerbate the disease during heterologous virus infection [18, 19] . Antibody-dependent enhancement (ADE) in dengue pathogenesis results from the increase in the efficiency of virus infection in the presence of nonneutralizing or sub-neutralizing concentrations of anti-E or anti-prM immunoglobulins [21, 23] . The attachment of antibody-virus complex to such Fcc receptor-bearing cells as monocytes and macrophages can lead to an increased virus replication [18, 24, 25] .