We subsequently assessed whether SNPs associated with IPA infection showed capacity to change putative transcription factor binding sites using FastSNP. The predictive functional analysis suggested an intronic enhancer function for the Dectin-1 rs7309123 SNP due to its location in transcription factor Cdxa (caudal type homeo-box transcription factor 1) binding site (GAAAGAC; score 1-2). These data suggest a central role of the rs7309123 in the susceptibility to IPA infection. None of the remaining SNPs associated with IPA infection was predicted to affect transcription factor binding sites or splicing or to introduce a damaging amino acid change.