Estimated sequencing costs of draft variola and draft NNs indicate that draft may require only one-quarter to one-half the costs of finished sequencing. Simulations of high-quality draft data indicated that it is as good as finished data for diagnostic signature prediction. The conservation range plots ( Figure 4A and B) are virtually identical for finished and high-quality draft, and indicate that $98% of the genome is conserved among sequenced isolates. For intermediate quality draft ( Figure 4C ) the conservation range plot is also similar to that for finished sequence, showing that $97% of the genome appears to be conserved. The range plots for the number of TaqMan signature candidates are very similar for finished sequence data, high or intermediate quality draft target, and high or low-quality draft NNs ( Figure 5A-D) .