In addition to the three ranking strategies introduced by Wang et al., several groups employed another consensus scoring method involving the linear combination of several scoring functions. In the study by Guo et al., five commercially available scoring function were weighted and summed to build a consensus score [33] by training with a 53-molecule set. Verdonk et al. also employed a linear combination of three scoring functions to rerank the compounds [34] . Although an improvement was found for this consensus scoring method, the correlation between the scoring function and the experimental binding affinity is relatively poor. For a quantitative linear combination of the original scoring functions, the method for determining the appropriate weighting factors (correlation coefficients) for each scoring function is a complex problem.