Results: The pregnancy at diabetes mellitus type 1 and GDM proceeds with complications: treat of pregnancy termination (64,0 % and 50,0 %), hydramnion (27,0 and 62,5 %), preterm birth (36,0 and 12,5 %). It was displayed decreasing of oxygen in mother's erythrocytes. At the diabetes mellitus in uterus of women in birth there are violations of spiral arteries as well as circulatory disorders (stasis, sludge, thrombosis and diapedetic bleedings), that is significantly expressed at gestosis. Tendency to cell form changing is observed in erythrocytes at diabetes mellitus, especially at diabetes mellitus type 1. The frequency of placental insufficiency in pregnant with diabetes mellitus type 1 were 75 %, at GDM-50 %. The gestosis accession were resulted to birth's increasing of children with prenatal injury of central nervous system at diabetes mellitus type 1 in mother and diabetic fetopathy at GDM.