The Genetic Association Database [2] (GAD) http:// geneticassociationdb.nih.gov is an archive of summary data of published human genetic association studies of many common disease types. GAD is primarily focused on archiving information on common complex human disease rather than rare Mendelian disorders as found in the Online Mendelian Inheritance in Man (OMIM) [6] . GAD contains curated information on candidate gene studies and more recently on genome wide association studies. It builds on the curation of the CDC HuGENet info literature database [3] in part by adding molecular and ontological annotation creating a bridge between epidemiological and molecular information. This allows the large-scale integration of disease based genetic association information with genomic and molecular information as well as with the software tools and computational approaches and that use genomic information [7] [8] [9] [10] [11] [12] . This report is a summary and analysis of the genes and diseases with positive associations in the Genetic Association Database with regard to replication, comparisons between diseases, and within broad phenotypic disease classes. Although GAD contains information on gene variation, this report is at the gene level only and does not consider specific gene variation or genetic polymorphism.