Table S1 Summary of prey and bait hit-rates for HSV-1, mCMV and EBV. Overview of the total number of preys and baits included in the Y2H screens, including the number of preys and baits which yielded interactions. The total number of preys and baits exceed the total number of proteins tested due to many of the proteins being cloned as both fragments and full-length proteins. Table S8 Average degree values for core and non-core proteins in all viruses. Average degree of core vs non-core proteins for all five interactomes. P-values were calculated with a Wilcoxon rank test between the degree values of core and non-core proteins. Found at: doi:10.1371/journal.ppat.1000570.s022 (0.06 MB PDF) Table S9 Ortholog protein interactions (predicted from KSHV) tested by Y2H and CoIP. List of orthologous interactions predicted from the KSHV interactome [23] which were tested by co-immunoprecipitation in HSV-1, mCMV and EBV. Results from the Y2H analysis of the predicted interactions are also indicated. Found at: doi:10.1371/journal.ppat.1000570.s023 (0.00 MB PDF) Table S10 Negatively predicted orthologous protein interactions (predicted from core interaction network) tested by Y2H and CoIP. Ten interactions were predicted to be negative, based on the fact that they were not observed in any of the five viral interactomes, and analysed by co-immunoprecipitation. Found at: doi:10.1371/journal.ppat.1000570.s024 (0.02 MB PDF)