The aim of this retrospective study was to assess the comparative frequency, gender, age, sub-site distribution and histologic differentiation of oral squamous cell carcinoma (OSCC) in Sistan & Baluchestan province, Iran. The medical records of 3070 patients with a histopathologic diagnosis of malignant neoplasm were reviewed during the 11-years period from 1995 to 2006.Available data suggested a steady increase in prevalence of OSCC during the last decades. .Of 3070 patients with malignancy, 217 cases had oral malignancy. The most common oral malignant neoplasia was OSCC (n=178, 82%) and then verroucose carcinoma (n=14, 6.4%).