A six-month-old male patient was admitted in our PICU after intubation owing to respiratory insufficiency due to bilateral pneumonia. Through nasopharyngeal secretions a positive PCR by Influenza A H1N1 virus was found. He was a 28-week preterm infant with a birth weight of 900 grams. He had bronchopulmonary dysplasia (BPD) because of mechanical ventilation during 2 months in the perinatal age. He also presented some malformations compatible with a genetic syndrome which was still being studied before admission (retromicrognathia, abdominal angioma in the medial line, low implantation of the ears, among others).