A variety of antibiotics can be used if the infection has been caused by a susceptible stain including broad-spectrum cephalosporins, β-lactam-β-lactamase inhibitor combinations, carbapenes, and fluoroquinolones alone or in combination with aminoglycosides. Multi-drug resistant infections, including carbapenes, aminoglycosides and fluoroquinolones resistance, are challenging, however the combination of intravenous or inhaled colistin with tigercycline, imipenem, rifampicin or azithromycin seems reasonably enough to achieve satisfactory efficiency, at least in vitro, due to synergic or addictive effects which these combinations offer. On the other hand it's unclear if these antibiotic combinations provide adequate therapeutically results in vivo [1, 2, 9, 10] .