Objective: Ligneous (wood-like) disease is a rare chronic pseudomembraneous inflammation of the mucous membranes which may also affect genital tract. The underlying pathogenesis is still unclear and an effective method of treatment has not yet emerged. Method: Here we present a 32 years old female patient presented to our clinic with 7 years of unexplained infertility. Her diagnostic infertility work-up revealed no abnormality. However, at gynecologic examination there was a thick and hard granulation tissue at the cervix extending to the posterior vaginal wall. Transvaginal ultrasound was unremarkable except for increased endometrial thickness. Results: Cervicovaginal and endometrial biopsy with diagnostic hysteroscopy was performed which demonstrated ligneous inflammation of both cervix and vagina. Endometrial biopsy was reported as chronic non-specific endometritis with dense fibrin deposition. Conclusion:. The disease may also affect other organs including oral cavity and eyes. This unusual condition is difficult to treat and lack of awareness makes the diagnosis also problematic. Objective: Differential diagnosis LM vs STUMP may be controversial, especially regarding necrosis evaluation; few studies address the relation between different treatments and their morphological effects. We aim to characterize a series LMs and putative STUMPs harboring necrosis. Method: Consecutive putative STUMPs (1995) (1996) (1997) (1998) (1999) (2000) (2001) (2002) (2003) (2004) (2005) (2006) (2007) (2008) (2009) (2010) (2011) (2012) and a series of LMs with necrosis diagnosed at CHSJ & IPOP-Porto. Clinical files, particularly previous hormonal treatment (HT), gross specimen and histology features. Results: 18 putative STUMPs and 35 LMs with necrosis. LMs mean age at diagnosis: 43 years; mean size: 9.0 cm (2.3-18); 45 % with other LMs; treatment: myomectomy (49 %) and hysterectomy (51 %); 23 % peri-partum, 8.5 % post-uterine artery embolization; 17 (49 %) previous HT: progestin (17 %), oral contraceptive-OC (20 %), hormonal-IUD (8.6 %), and medical assisted reproduction (8.6 %). STUMPs mean age at diagnosis: 45 years; mean size: 10 cm (2.0-20); 44 % with other LMs; low mitotic index-MI (mean 3.16; median 1/10HPF); slight cell atypia; variable ischemic/ tumor-type necrosis. Treatment: myomectomy (22 %), hysterectomy (83 %) and radiotherapy (11 %); 12 (67 %) previous HT: progestin (22 %), OC (39 %), hormonal-IUD (11 %); no recurrence in remaining cases (n=6): median follow-up: 97.5 months. Conclusion: LMs with necrosis and STUMP may display overlapping features. Diagnosis of STUMP should consider previous HT, detailed morphology (necrosis type/atypia/MI), to prevent overdiagnosis of STUMP. positivity. PLAP and Chromogranin were negative. Ki-67 nuclear positivity was found in less than 1 % of Sertoli cells and in about 1 % of Leydig cells in hyperplastic areas. Karyotype was 46xy. Conclusion: Although, surgical pathologists encounter TFS rare in a clinical practice, they should be aware of this condition, especially in lack of relevant clinical data, when it could be interpreted as a tumor. Objective: Frozen section (FS) diagnosis of ovarian mucinous tumors can be difficult due to the size of these tumors, heterogeneity and potential risk of metastasis from gastrointestinal (GI) neoplasms. Method: We reported 79 ovarian mucinous tumors submitted for (FS) evaluation between January 2007 and Avril 2012 was conducted. Results: FS and final pathology results were collected. The average tumor size was 22,1 cm (1-55 cm). The FS and final pathology diagnosis were concordant in 84,8 % (67/79) of the cases. Of the 12(15,1 %) discordant cases, one (1,2 %) was downgraded and 8 cases (13,9 %) were upgraded. Of the 30 tumors interpreted as borderline mucinous tumors (BMT) on FS, 8(26,6 %) were malignant at final diagnosis (4 ovarian, 4 GI), 21 (70 %) remain as BMT and 1 (3,3 %) was benign. Of the 18 benign tumors on FS, 3 cases (17, 6 %) were upgraded to BMT at final diagnosis. Tumors with a malignant diagnosis on FS (30 cases) were 100 % concordant with final diagnosis. Conclusion: Our study showed a 15,1 % rate of discordance between FS and final diagnosis. Given that GI origin is a possible finding, intraoperative assessment of the appendix should be performed in all mucinous ovarian tumors.