Several public health strategic interventions are required for effective disease prevention and control of the multifaceted issues posed by avian influenza [6] . Of these interventions, it is necessary to create a communication plan to keep the population fully and adequately informed on how to avoid or reduce exposure. A similar approach has been applied during the SARS epidemic [7] and the implementation of appropriate infection control measures was a key aspect for its control. In the past years a limited number of studies have been published investigating knowledge, attitudes, and practice about avian influenza among target groups [8, 9] and general population [10] [11] [12] [13] . This area of investigation seems to be an important one because members of the public often misinterpret their risk of health problems. Therefore, the objectives of the present investigation were to assess the knowledge, attitudes, and behaviors relating to avian influenza and to evaluate the effect of several potential predictors on such outcomes of interest in an adult population in Italy.