The immunohistochemical concordant evidence of Lf in bone metastases and corresponding primary carcinomas strongly supports the hypothesis of an autoctone production of this protein by the neoplastic elements themselves in order to get a greater availability of iron for their increased turnover. Results: It was observed a negative correlation between IL1/IL6 and IL17/Foxp3 concentration in the SF as measured by FC, before the treatment. In the SM, IL6 and MMP9 were strongly expressed in macrophages, fibroblasts, endothelial cells and the extracellular matrix of control cases, but reduced significantly in the treated cases (p< 0, 05). Il 17 and Foxp3 positive cells remained costantly in a reduced number in the MS. Conclusion: As the proinflammatory cytokines decreased after the therapy, we can conclude that these are more efficiently influenced than some immune cells participating in the autoimmune process.