The soundness of the hypothesis will not be commented upon, because there is so much doubtful with the basic premise. Start with a simple self-replicating autocatalytic set of molecular species. If mutation-based evolution can operate on this set, there will be an increase in the complexity of the molecular species in the set. This increase in complexity is driven primarily by chemical potential and reduction in free energy. The increase in the number of new molecular species capable of participating in the reaction set results in more ways to dissipate the free energy, and thus an increase, not a decrease, in entropy [28] [29] [30] .