Baculoviruses are enveloped viruses possessing a rod-shaped nucleocapsids in which double stranded circular DNA genome of 88-135Kbp is packaged (10) . Baculoviruses are generally utilized as a vector for the high level production of recombinant proteins but they could be also employed in gene transfer to mammalian cells (11) (12) (13) . Several research groups have demonstrated that vaccination with recombinant baculovirus can induce high-level humoral and cell-mediated immunity against various antigens, suggesting that baculovirus could be used as a vaccine carrier (14, 15) . In addition, it has been reported that immunization with a recombinant baculovirus expressing the hemagglutinin gene of influenza virus elicited a strong innate immune response and protected mice against influenza virus challenge (16) . Moreover, it is known that there is no baculovirus-specific immunity in mammals that might interfere the action of baculovirus-based vaccine (17) (18) (19) .