Objective: Primary breast melanoma is a very rare tumour accounting for <5 % of all malignant melanomas. The malignant melanoma can be with different manifestation in the breast (primary breast tissue or primary breast skin melanoma as well as metastatic melanoma). Method: In this study 4 cases of breast melanoma were identified from our records of the past 3 years (0.41 % of all breast cancer cases). A histological and an immunohistochemical (IHC) study was performed using antibodies against CKAE1/3, HMB-45 and Melan-A on both the biopsy and operation material. Results: Obtained results showed that in 3 cases pigmented, epitheloid and spindle cell melanoma, but in one case epitheloid cell amelanotic melanoma was found. By IHC the melanoma cells expressed HMB45 in three cases, melan-A and S100 in all cases. No expression of CKAE1/3 was observed. Conclusion: Careful histological and immunohistochemical examination of malignant tumour is essential for adequate diagnosis, follow-up and treatment of breast melanoma.