Results: The serum level of AFP declined in two groups after 2 months. For treatment after six months, AFP in four combined groups was rose lower than two combined group (X 2 =5.06, p<0.05). CT and Doppler ultrasound examination, four combined groups was superior than two combined groups to the control in tumor shrinkage (X 2 =8.29, p<0.01) and blood supply X 2 =6.81, p<0.01), relapse and mortality are also less. Conclusions: RFA in combination with hepatic artery-portal vein chemotherapy and ethanol injection is a safe, effective combined method and has less complication in treatment of advanced HCC.