Another group of PLs that were preferentially expressed in DENV-infected cells were the lysophospholipids (LPLs) ( Figure 3A and B). These lipids result primarily from the hydrolysis of PC by phospholipase A2-type enzymes (PLA 2 ) and represent a PL that is missing an acyl chain [27] [28] [29] [30] . In DENV-infected cells, there was a preferential up regulation (,3 fold) of these lipids compared to both UV-DENV and mock controls at the 36 hr time point. This expression was slightly down regulated at the 60 hr time point to about ,1.5 fold above the mock. In UV-DENV exposed cells, LPLs were undetectable at the 36 hr time point, while at the later time point, they were similar or slightly above the mock levels. As shown in figure 3H , LPLs with C16 acyl chains were up regulated at both time points while there was a selective up regulation of LPLs containing C18 acyl chains only at the early time point ( Figure 3H ). The C16 LPLs have been implicated in pro-apoptotic signaling pathways. This observation of selected LPL expression presents an attractive hypothesis that chain length differences may dictate specific roles for LPLs during virus infection.