Cryoelectron microscopy (cryoEM) was used to visualize the effect of the DN57opt and 1OAN1 peptides on DENV-2 viral particles. Control dengue virions exhibited the normal, nearly smooth outer surface typical of mature flaviviruses [42] . The surfaces of the virus particles werebecome followingrough after treatment with peptides, implying a possible rearrangement of the envelope glycoproteins (Figure 4) . The treated virions no longer showed icosohedral symmetry, Attempts to reconstruct the structure of virus complexed with DN57opt and 1OAN1 structures by imposing icosahedral symmetry failed, indicating the viruses are no longer icosahedral. Control treatments with equivalent DMSO alone did not produce this morphological alteration.