Proposed involvement of mast cells in nociceptive signaling in pancreatitis Figure 7 Proposed involvement of mast cells in nociceptive signaling in pancreatitis In pancreatitis, mast cells may migrate to sites of inflammation, in response to release of mast cell chemoattractants. Mast cell degranulation products may modulate neurotransmission directly by activating proalgesic receptors and channels such as trka (NGF), TRPV1 (NGF) and PAR-2 (tryptase and trypsin). 