The use of synthetic peptides as substitutes of native antigen in immunoassays has been highly recommended for the diagnosis of infectious diseases by different authors [13, 30, 35] . Synthetic peptides are applied successfully in diagnosis of viral and bacterial infections [36] [37] [38] [39] . Compared to a metazoan parasite, viruses and bacteria in general have smaller genomes and accomplish less complex post translational protein modifications, which might imply more rapid success in identification of immunodominant peptides. It even allows for analysis on whole proteome level [40] . Here, we investigated the use of synthetic peptides of 30-50 amino acids in length for the use in immunodiagnosis of human hydatid disease. We provided proof of principle for the selection of synthetic peptides by bioinformatic means and for screening on a microarray platform for diagnostic reactivity. 17 out of 45 peptides on the microarray proofed reactive with sera from echinococcosis patients.