Results: The main symptoms were arthralgia, weight loss and diarrhea. The endoscopic aspect of the small bowel mucosa varied from congestion, granularity of the mucosa to whitish plaques. All patients showed PAS positive, diastase resistant, Ziehl-Neelsen negative macrophages in the lamina propria of the duodenal mucosa and, in one patient, suspected for lymphoma, in an abdominal lymph node. The diagnosis was confirmed by electron microscopy in all cases. Classic Whipple's disease was the diagnosis in all five cases, but one patient showed involvement of the endocardium and two patients showed lymphadenopathies. Conclusion: Clinical evolution was favorable under long-term antibiotics (Cephtriaxone/Trimethoprim-Sulfamethoxazole) and follow-up biopsies in three patients showed a normal endoscopical mucosa and a reduced but persistent number of PAS positive macrophages in the duodenal mucosa. Results: Eleven cases of NEN of gastrointestinal tract were identified. They were 6 men and 5 women with a mean age of 53.09 years. The most common localization was the appendix (7 cases). The 4 other cases were localized in the small intestine, the ileo caecal valve, the fundus and the bulb. The mean tumor's size was 13.8 mm. Mitoses were absent in the majority of cases (72,7 %). All the tumors were well differentiated classified as grade 1 in 9 cases and grade 2 in 2 cases. The tumor was aggressive in 2 cases. The small intestine's NET was multifocal infiltrating the subserosa with lymph node metastasis classified pT3 N1. The ileo caecal valve's NET was also aggressive with lymph node and hepatic metastasis classified pT4N1M1. All patients underwent surgical treatment.