Results: E-cadherin expression was focally retained in the tumor cell membranes and in the tumor cell cytoplasm of the papillary, follicular and oncocytic thyroid cancers, weather in anaplastic cancers it was almost lost (p= 0.0042, and p= 0.019, respectively, Fisher's Exact Test). The expression of β-catenin in tumor cytoplasm and membrane in papilary cancers was higher as compared to that in the other tumors (p=0.111, and p=0.0104, respectively). Conclusion: Not surprisingly, the presence of aberrant expression of E-cadherin and/or β-catenin in thyroid cancer has been associated with better patients' prognosis and more well differentiated tumor histology.