These analyses agree with other studies showing prior autograft failure to be one of the major risk factors for disease progression after non-myeloablative allo-SCT. 27 The observation that prior autograft failures do poorly with an allo-SCT argues against the recommendation some have made to delay an allo-SCT until disease progression after initial treatment or autologous transplant. 7 In some retrospective analyses, a non-myeloablative allograft was able to overcome certain high-risk FISH characteristics such as the 4;14 translocation. 28 Our patient population contained too few patients with 4;14 to analyze this separately, however, in the multivariable analysis only high B2 microglobulin and not adverse cytogenetics were associated with inferior outcomes. This does not mean that cytogenetics are not important but merely reflect a limited number of observations in our database to directly address that question.