278 potentially relevant reviews were obtained, after selection (according to inclusion and exclusion criteria), a total of 58 Cochrane reviews were eligible for our study, a full list of reviews is included in Table S1 . Of the 58 reviews, one review [49] included herbs originated in China, India and Japan; interventions in another review [55] concerned both herbal and chemical medicines. In these two cases, we extracted and analyzed the information relating to CHM.