Let x be the size of complete proteome (number of functional proteins before post-translational modifications), let t be the average size of cellular proteome of differentiated cells, cn is the number of cell types, a 1 , a 2 , a 3 ,..., a cn are the diversities of differentiated cellular proteomes from t. Because many genes expressed in the differentiated cells are the same, t+a 1 +a 2 +a 3 +...+a cn =x, then the information to produce diverse differentiated cells is: