On the other hand, natural gradients on physical biochemical properties can also be challenged in a cancer cell. This in turn derives in metabolic processes running under abnormal parametric circumstances. It is well-known that compartimentalization, in biological systems, naturally require the existence of mechanisms that would keep some key state variables relatively constant, or within bounds, for normal operation of the metabolic processes. One example is very illustrative and a case in point. Instead of demons, holes, or valves, the cell requires pores in its membranes to allow osmotic regulatory processes, yet it should preclude the conduction of protons. This is a nanotechnological design problem not faced by Maxwell, but certainly solved by biological systems without the need of an ''intelligent being'' as Mawell cleverly pointed to Tait in his letter.