The use of GL in acute and chronic hepatitis is due to its hepatoprotective, immunomodulatory, and antiinflammatory effect. It reduced ischemia/reperfusion (I/R-) induced liver injury [85] and inhibited hight-mobility group box 1 (HMGB1), an inflammatory cytokine that acted in inflammation and organ damage in hepatic I/R-injury [85, 86] .