Conclusions: High levels of catastrophic health spending and poverty co-exist with significant economic inequality and poverty in Guatemala. With health system characteristics and an economic structure similar to many other developing countries, international experience provides useful lessons to help Guatemala devise innovative financing and payment mechanisms to address these concerns. The aim of this research is to demonstrate why in global governance Pareto principle from an economic perspective and liberty principle from a political perspective are incompatible. Impossibility Theorem is applied to analyze the international relations among players with different preferences. The theoretical proposition of incompatibility is followed by the example of conditional foreign aid, with distinction of indirect liberty and direct control. Two rival hypotheses, global Pareto condition and national liberty condition, are tested in the empirical evaluation of the foreign aid conditional on the Washington Consensus from 1989 to 1999. First, small-N design is to compare the pre-treatment and post-treatment situations in 3 representative countries, as the non-complier, partial-complier and complete-complier of the Washington Consensus. Second, large-N regressions are to estimate the effect of foreign aid on social developments measured by health outcomes: (1) foreign aid without controlling for the adoption level of the Washington Consensus, which reflects in liberty principle; (2) foreign aid after controlling for the adoption of the Washington Consensus, which reflects in Pareto principle. Furthermore, responding to the criticism of "what causes what" in the relationship of underdevelopment and foreign aid, oil price and oil reserve are introduced as instrumental variable (IV) into the model to isolate the causation of foreign aid on social developments, especially health outcomes. Finally, the concept of overlapping consensus from John Rawls is incorporated to interpret why partial-compliers are better off than both non-compliers and complete-compliers given conditionality of foreign aid. The strategy is to not only work within the domain of the impossibility theorem with empirical evidences but also step out to examine the assumptions that constrain the outcome through the inspiration of overlapping consensus. [Objectives] Depression is a heterogeneous heritable psychological trait, also influenced by environmental factors. Previous studies have found the associations between major depression and gene polymorphisms such as serotonin transporter gene linked polymorphic region (5-HTTLPR). Since fatty acid (FA) metabolism appear to contribute to the pathoaetiology of affective disorders, we examined the associations between depressive symptoms and genetic variation in FA metabolism-related genes.