The World Wide Web server for ViralORFeome is Apache (http://www.apache.org/) with Hypertext Preprocessor (PHP, http://www.php.net) and Asynchronous JavaScript and XML (AJAX) technologies. The relational database management system for ViralORFeome is PostgreSQL (http://www.postgresql.org/). ViralORFeome Entity-Relationship (ER) model was divided into five interconnected parts: 'Taxonomy', 'Genome', 'ORFeome', 'Interactome' and 'Users' schemes (Supplementary Figure S1 ).