Gains of REL, BCL11A, or MYCN have been reported by Chapiro et al. [5] to occur in 10% CLL, a prevalence that is higher than the 2-3% prevalence observed in our cohort. The discrepancy between our study and the study by Chapiro et al. [5] may be explained by the differences that distinguish the two CLL cohorts. Indeed, Chapiro et al. [5] analyzed REL, BCL11A, or MYCN in 86 CLL, all Binet stage B-C, at the time of treatment requirement. On the contrary, our study was based on a consecutive series of 176 CLL, that included all Binet stages and that in all cases have been analyzed at the time of diagnosis.