A study examined the growth inhibitory effect of P. emblica on human hepatocellular carcinoma (HepG2) and its synergistic effect with doxorubicin and cisplatin: the effect of chemotherapeutic agents may be modified by combination of P. emblica and be synergistically enhanced in some cases [176] . Depending on the combination ratio, the doses for each drug for a given degree of effect in the combination may be reduced. The mechanism involved in this interaction between chemotherapeutic drugs and plant extracts remains unclear and should be further evaluated.