The median time to first AECOPD and the rate of AECOPD per patient-year are shown in Figures 1-3 Table 2 relative to the various definitions of MBL deficiency (only five patients had MBL concentrations # 50 ng/mL, precluding life table analyses for patients in this subgroup). Regardless of the MBL concentration used to define deficiency, no association between the time to first AECOPD, or the rate of AECOPDs and MBL concentration was observed in the population as a whole, or in either treatment subgroup. Nonsignificant trends favoring a longer time to first AECOPD were seen in the subgroup of subjects with MBL concentrations , 100 ng/ mL compared with those with concentrations $ 100 ng/mL ( Figure 1A and C). No difference was observed in MBL concentrations in subjects experiencing no, one, two, or at least three AECOPDs during the course of the study in the population as a whole, or in either treatment group (Table 3) .