Luo et al. [27] [28] [29] compared the sequences of the mitochondrial genome in HAPE patients and rats at high altitude versus sequences from healthy individuals at high altitude and animals at sea level, and identified single-nucleotide polymorphisms in nine genes in mitochondrial DNA (T6680C, C3970T, G3010A, A13497G, c15508T, G4164G, G1598A, C16111T, and T7684C). All of the affected genes encoded proteins controlling mitochondrial electron transport. Based on singlenucleotide polymorphism of mitochondrial DNA T6680C, DNA C3970T, and DNA G3010A, they developed a kit that can be used to predict susceptibility to HAPE. This kit can be used to screen subjects for susceptibility to HAPE before ascending to high altitude. In another study, Qiu et al. [30] compared genetic parameters of patients with HAPE, as well as people living in Tibetan and Han Chinese migrants. They found that human leucocyte antigen (HLA) DR6, particularly DR6(1402), was associated with increased susceptibility to HAPE. Thus, they speculated that susceptibility to HAPE was not only related to genetic factors but was also influenced by some susceptibility genes.