Objective: We assessed clinicopathologic features and outcomes of 24 cases of atypical vascular lesions (AVL) in patients submitted to radiation therapy for breast carcinoma. Method: Data from all patients were retrieved from the files of the European Institute of Oncology (EIO), Milan. Histopathological review of all cases was carried out. Results: All patients were women (median age: 58 year, range: 36-81 year). Median lesion size was 0.5 cm (range: 0.3 to 1.1 cm). Median latency interval from radiation to AVL diagnosis was 49 months (range: 17 to 124 months). 62.5 % of cases presented as an erythematous unique papule confined to superficial/middermis with proliferation of thinwalled, vascular channels, lined by a single layer of bland endothelial cells. No prominent nucleoli, mitoses or blood lakes were seen. Patches of chronic inflammatory infiltrate accompanied all AVL. One patient (4.2 %) developed local recurrence, and two patients (8.3 %) developed angiosarcoma in the previous biopsy site, 19 and 89 months later. Margin involvement was associated to unfavorable outcome. Conclusion: Our data suggest that post-radiation AVL and angiosarcoma may represent a spectrum of the same disease process. The development of local recurrence and subsequent angiosarcoma indicate that AVL must be completely excised, with free surgical margins, and patients must be accompanied by clinical exams and imaging. Objective: Gastric dysplasia is classified as gastric/foveolar and intestinal/adenomatous according to morphological (architectural and cytologic) features. The immunophenotypic classification of dysplasia, based on the expression of mucins and CD10, recognizes three major types: gastric (MUC5AC and/or MUC6); intestinal (MUC2 and/or CD10); hybrid (gastric and intestinal markers). CDX2 is a transcription factor responsible for early intestinal differentiation. ALDH1 is recognized as a stem cell marker in several organs. Method: Nineteen cases of dysplasia were classified as gastric/foveolar (n=8) or intestinal/adenomatous (n=11) and graded as low-grade (n=9) and high-grade (n=10). Immunophenotypic classification showed gastric (n=5; 26 %), intestinal (n=6; 32 %) and hybrid (n=8; 42 %) phenotypes. Results: Cases classified by morphology as gastric/foveolar-type displayed gastric (50 %) or intestinal (50 %) immunophenotype, whereas intestinal/adenomatous-type cases displayed gastric (9 %), intestinal (55 %) or hybrid (36 %) immunophenotype (p=0.023). High-grade dysplasia was identified in cases with gastric (80 %), intestinal (17 %) and hybrid (63 %) immunophenotype (p=0.085). CDX2 expression was significantly lower (p=0.044) in gastric (60 %) than in intestinal and hybrid immunophenotypes (100 %). ALDH1 expression was displayed only in gastric (80 %) and hybrid (50 %) immunophenotypes (p=0.023). Conclusion: Gastric dysplasia is heterogeneous and morphology is insufficient to elucidate cell differentiation. High-grade dysplasia, decreased CDX2 expression and high ALDH1 expression are associated with gastric immunophenotype.