Objective: Cap polyposis is a rare colorectal disease characterized by mucoid, bloody diarrhea associated with multiple inflammatory polyps covered by a cap of fibrinopurulent mucous. The disorder was first described in 1985 and up to date a small number of cases has been reported in the literature. Method: We report two cases with multiple polyps of rectum and sigma, which were histologically diagnosed as cap polyposis. Results: The cases were two males on age of 18 years and 64 years. In both cases there was a history of mucoid and bloody diarrhea. On the basis of colonoscopy findings, in the young patient there was a broad differential diagnosis including M. Crohn, inflammatory pseudopolyps and Cronkhite-Canada syndrome. In the second case the clinical diagnosis was polyps of sigma. Endoscopic biopsies and polypectomy were done. In both cases, the histology showed typical histological features of cap polyposis -polypoid lesions containing elongated, tortuous and often distended crypts covered by a cap of inflammatory granulation tissue.