It is also possible that as a result of mutations more than one base pair are added during the repair and replication phases. Such actions can be expected to lead to further higher order terms being added to equations 16, 17 . That the third order terms seem to be required for good fits to some of the gene sequences has already been noted earlier. Such modifications to the intra-purine, intrapyrimidine relationship can result in deviations from the smooth distribution that first order approximation equations like Eq.16, 17 would imply. This could be the underlying reason for the deviations between the actual representative plots of the various sequences and their fitted curves observed in several graphs.