Sirolimus ameliorates cyclosporin-induced nephrotoxicity in a rat modelfocus on renal lesions, oxidative stress, inflammation, proliferation and angiogenesis J. Sereno * , A. M. Romão, M. Teixeira, B. Parada, C. Mega, H. Vala, E. T. lemos, F. Teixeir, F. Reis * IBILI, Medicine Faculty, Laboratory of Pharmacology and Experimental Therapeutics, Coimbra, Portugal