To the best of our knowledge, this is the second study that finds higher sRAGE levels in plasma of sepsis nonsurvivors compared with survivors [37] . This has Variables included in equation: RAGE, sRAGE, HMGB-1, SOFA score, APACHE II score, gender, age discrepancies with mouse model studies of sepsis after CLP [22] . This could be in part explained by different kinds of sepsis, different etiologic agents, and what was difficult to determine in our study, the time of measurement after the immunologic process started. We do not know if sRAGE concentrations were enough to bind HMGB-1, after they had scavenged AGEs and other RAGE ligands. Moreover, the higher concentrations found in sicker patients could represent sRAGE modified structurally and functionally during sepsis, diminishing its binding and neutralizing capacity.