Stanislaw FW et al [77] have reported the anti-trypanosomal activity of 5'-deoxy-5'-(E)-(iodomethylene)adenosine, which is a known inhibitor of AdoHcy hydrolase, [78, 79] The 5'-deoxy-5'-(E)-(iodomethylene)adenosine (EIDDHA) and its 6-N cyclopropyl analogue (Figure 28a , b) have shown promising in vitro inhibitory activity (IC50 at 9 and 12 μg/mL) against T. brucei. The utilization of adenosine analogues as anti-parasitics should be explored as a therapeutic paradigm, as it has been shown previously that inhibitors of AdoHcy hydrolase are also very potent inhibitors against the growth of Plasmodium falciparum [79] . This class of 6-N-cyclopropyl adenosine analogues modified at carbon 5', does not exhibit an inhibitory effect on human or parasite forms of the enzyme and displays only marginal antiviral activity in comparison to analogues which have been unmodified at 6-amino position (that are potent inhibitor of AdoHcy hydrolase). Therefore these compounds require further structural modification in order to develop newer analogues with improved activity against T. brucei.