Both DgB and DgH virions are capable of stimulating an NF-kB response (Table 2) , a result that correlates with the preliminary microarray data (Table 1) . Transcripts for both BIRC-2 and BIRC-3 are increased above the two-fold threshold after inoculation with DgB and DgH HSV-1 but not DgD. There appears to be no change in BIRC-1 expression after inoculation with any of the three entry-defective mutants. Components of the NF-kB transcriptional complex, NFKB1 and REL, showed similar levels of increased transcription after binding by DgB and DgH virions, a response that was absent in cells stimulated with gDdeficient virions. Two markers of inflammation, CCL2 and PECAM1, also showed a significant change in gene expression at 6 hpi with entry-defective HSV-1 lacking gB or gH but not gD.