Self-reported survey data from the 2010 Behavioral Risk Factor Surveillance System (BRFSS) was analyzed. Because the relationship between ILI and influenza infection is strongest during the influenza season, we limited the study sample to adults aged 65 years and older who participated between January and March 2010 (N035,628). We adjusted for three categories of individual-level factors: sociodemographics, health behaviors, and history of chronic disease diagnoses. We used stratified, weighted multivariable logistic regression to estimate the association between receipt of the influenza vaccine in the past year and report of ILI in the past month via adjusted odds ratios (aOR) and 95% confidence intervals (95% CI).