This study aims at developing a model on risk communication for preventing and controlling diabetes mellitus. A six-month study was conducted in March to September 2008. Literature reviewing from both national and international articles provided a conceptual framework and a process for developing risk communication model which was preparing, assessing and working with the community. Stakeholders were approached to involve in all steps of the study. The setting of the study was in Mugdhaharn Province, Thailand. The conceptual framework of the risk communication was developed from literature review comprising two major components: 1) risk assessment and 2) risk management. In relation to risk assessment, qualitative and quantitative techniques were applied. The target groups of risk assessment were people at risk of diabetes mellitus, family members, and related persons. The issues to be assessed covered risk factors, risk perception, strengths and weaknesses of self care and risk contexts. The results of the risk assessment led to the guidelines and strategies for coping with the risk factors. Regarding the risk management, the guideline and strategies were initially implemented by focusing on the engagement of the stakeholders which resulted in learning and better understanding among related people. The proposed model reflecting two significant components and its process was accepted by stakeholders and further implemented by local health care team in the study area. HIV prevention programs with adolescents use different strategies with varying degrees of success. Behavioral programs have been effective in reducing risk factors, although data on the most effective components are needed. This symposium is addressed from an international point of view different experiences of program evaluation focused specifically on HIV, applying experimental methodology, with high-risk and general population, and combining the evaluation of empirical studies, the quantitative review and proposed new challenges.