A study using individual-based modelling in the United Kingdom and United States examined the effects of antiviral treatment and prophylaxis, vaccination, case isolation, household quarantine, school and workplace closure and travel restrictions in pandemics with Ro of 1.7 to 2.0. It found that external or internal travel restrictions alone would delay spread by two to three weeks only if more than 99% effective [16] . Reactive school and work-Flow diagram for selection of combination strategy modeling studies Figure 1 Flow diagram for selection of combination strategy modeling studies.