Method: We report a 30 year old man with end stage renal disease underwent kidney transplantation from a CMV negative donor on June 2011. After 1.5 months he admitted with fever, generalized body pain, oral aphtous ulcers and epigastric pain accompanied by malaise. Endoscopic examination revealed multiple antral erosions with surrounding erythema. Clinicopathological investigations revealed CMV viremia with a Ig-M antibody titer and CMV gastritis confirmed by histopathological examination. Results: The patient was started on intravenous (IV) ganciclovir 5 mg/kg per day every 12 h initially for 3 weeks, afterwards the fever decreased; cell blood counts throwback to normal ranges and general condition of the patients improved.