Considering the ease in design and construction of plasmid DNA used to target a particular neoplasm, biological adjuvants can be tailored and encoded within the same DNA vector as well [35] . A vast array of molecules able to modulate immune responses can be delivered (Table 3) . They include chemokines to attract APC [93] , activating cytokines [94, 95] , costimulatory molecules, APC-targeting antibodies, and molecules to manipulate antigen presentation and/or processing [96] .