In animal study, it has been demonstrated the capacity of curcumin to improve liver histology of NAFLD. The NASH model was induced by highfat diet combined with carbon tetrachloride. These rats were successively treated with curcumin and curcumin derivative. The results showed a remarkable reduction in serum ALT (U/L), AST (U/L) in rats treated with curcumin derivatives. The degrees of fibrosis were also significantly alleviated. The reduction of the gene transcriptions of TNF-alpha, NF-kappaB, and HMG-CoA was the mechanism proposed by wich curcumin exercise its beneficial effects in NASH.