Objective: Biological behavior of conventional clear cell renal carcinoma (CCRC) is associated with tumour stage and grade. Cancer progression with metastasis is part of a process epithelial-mesenchymal transition (EMT) and is joined with invasiveness due to adhesion and cytoskeleton change. The central role of the EMT mechanism is attributed to Snail factor. The intermediate filament expression is changed through the progression of many types of neoplasms. These changes are organ or tissue specific and depend also on the degree of malignant transformation (genome instability acceleration). The expression changes of cytokeratin 18 (CK18) are signs of aggressive biological behaviour in some tumour types -e.g. colorectal and breast carcinoma (downregulation of expression) or CCRC (upregulation of expression). The expression of Snail and CK18 molecules and mRNA CK18 levels correlate to stage and grade of CCRC (according Messai et al. 2010) . Objective: Study was based on the expression of immunohistochemical markers (CK18, CK7, vimentin, Snail, CD10) in 15 cases with evaluation of the primary tumour and its metastasis. Results: The difference and similarity of intensity and percentage of positive neoplastic population between the primary and the secondary carcinoma will be presented. Conclusion: Snail and CK18 seem to be potential tumour progression factors and may be included in so called personalised medicine. Objective: Sarcomatoid carcinoma (SC) of the prostate is a rare variant of prostatic cancer representing less than 1 % of prostate tumors. Tumors are most commonly composed of an admixture of both malignant glandular and spindle cell elements. The sarcomatoid component can vary from 5 % to 99 %. Method: We report the case of a 63-years-old patient with an invasive tumor of the prostate for which he had a radical prostatectomy. Histopathological examination showed that the tumor was responding to an undifferentiated proliferation made of beaches and clusters of pleomorphic cells usually spindle-shaped, with eosinophilic cytoplasm, and elongated or oval nuclei, which are very irregular, sometimes monstrous, multinucleated, basophils with numerous mitotic figures. In some places, there were areas of glandular differentiation and foci of comedocarcinoma. Immunohistochemical study showed immunoreactivity of spindle and pleomorphic cells with cytokeratin and vimentin. Results: The diagnosis of sarcomatoid carcinoma of the prostate-grade Gleason 5+5 was confirmed. Conclusion: SC of the prostate is an exceedingly rare tumor. Retrospective analyses render prostate SC as one of the most aggressive prostate malignancies. The prognosis is dismal regardless of other histologic or clinical findings. extra-uterine extension (FIGO stage II-IV) were significant parameters of poor prognosis. No multivariate analyses were performed due series limitation. Conclusion: Detailed pathology evaluation, including histological subtype, and FIGO stage are essential in the adequate management decision/prognosis evaluation of U-LMS. Objective: Over 90 % of women with endometrial cancer show signs of uterine bleeding, so most cases are diagnosed at an initial stage. This study covers two patients who presented the first signs of this disease in an exceptional manner. Method: Case-1 A 71-year-old woman was afflicted with a six-month toxic syndrome. An omentum tumor was identified in the x-ray. Eleven days after the excision, she demonstrated oliguria, dysuria, and scant uterine bleeding. The pelvic ultrasound revealed a uterine mass. Case-2 A 56-year-old woman demonstrated disabling right inguinal pain. After an x-ray examination of her pelvis, a metastasis was suspected. A biopsy confirmed it. The immunochemistry pointed to a gynecologic, pancreatic or intestinal tumor. The computer tomography scan revealed a uterine mass. Results: The first case only suggested an estromal gastrointestinal tumor or a mesothelioma, misdiagnosing and missing the endometrial carcinoma. The second case was uncommon as bone metastasis is found with solid tumors but seldom occurs with endometrial cancer and even less so as a first sign. Conclusion: We must consider endometrial cancer at signs of uterine bleeding, however, further investigation is required in order to consider the 10 % who do not show the common signs.