HCV is a globally important human pathogen afflicting more than 170 million people worldwide [12, 13] . HCV, a hepacivirus member of the Flaviviridae family and an enveloped virus, is encoded by a single-stranded positive-sense RNA genome [14] . Viral RNA is directly translated by the host machinery into a single polyprotein, which is cleaved by host and virus-encoded proteases to release the individual structural (core, E1, and E2) and non-structural (NS) proteins (p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B) [15] . During infection, HCV-encoded proteins promote reorganization and accumulation of LDs in the perinuclear region of the cell [16] . The HCV core protein is targeted to LDs [17] and orchestrates the assembly and release of infectious viral particles during the late stages of infection [18] . Hence, disrupting the interaction of the HCV core protein with LDs compromises this essential stage within the HCV lifecycle [8, 10, 11] .