Could it be possible that we can track cancer progression by looking at some of these ''Maxwell demons''? We have seen in Figure 10 , that AQP3 has a reduced expression with increased progression in our melanoma dataset. Cao et al., reported that ultraviolet radiation induced AQP3 down-regulation in human karatinocytes; thus AQP3 has become a strong and plausible link between UV radiation, skin dehydration [186, 715] and photoaging [189] . This may indicate an impared function on skin hydration [184, 185, 716, 717, 718, 719] . The expression of AQP3, as well as AQP1, AQP5, and AQP9 seem to be correlated with melanoma progression, indicating a common pattern of downregulation from the higher values in normal skin and benign nevi (see Figure 17 ).