Clinical outcome from HRV strains isolated from pediatric outpatients Among the pediatric patients, 46 were males and 18 females, and their age ranged from 5 months to 14 years. The majority of HRV infections were diagnosed between 2 and 6 years of age (84.6%). Bronchitis (73.4%) and pneumonia (26.6%) were highly prevalent in children with comparable incidence in HRV-A and HRV-C infections (Table 5) . Moreover, the ratio of pneumonia over bronchitis (36.2%) was comparable to that in the whole cohort of 827 children (40.7%). Only one child among the 64 HRV-positive patients had asthma and was co-infected with HRV-C, influenza A virus (IAV) and respiratory syncytial virus (RSV) ( Table 5) , whereas 100 of the 827 patient were diagnosed with asthma. HRVs were isolated throughout the 2 years, with a predominance of HRV-C viruses in the cold season (Table 5) . Interestingly, different HRV genotypes were detected within the same period (for example, N1 and N4, N9 and N11/N12, N44/N48 and N51, and N55/N56 and N62/N67), with a larger diversity and distribution of individual or paired HRV-A genotypes compared to HRV-C strains, which clustered in closely-related genotypes (Fig. 2, Tables 2 and 3) . Conversely, N4 and N21 strains of samples collected at 10 months interval showed 99.8% identity (Fig. 2) .