Neither AMD alone nor LPS alone affected ALT activity at any of the doses tested. In rats cotreated with AMD and LPS, serum ALT activity was dependent on both AMD ( Fig. 2A) and LPS (Fig. 2B) doses. Significant increases in ALT activity were observed with AMD doses 300 mg/kg (p < 0.05) and with LPS doses 1.2 3 10 6 EU/kg (p < 0.05). 400 mg/kg and 1.6 3 10 6 EU/kg were selected as AMD and LPS doses for subsequent studies, respectively.