Another group of proteins which was suggested as markers of caveolae are flotillins (also known as reggies) which were discovered as proteins involved in nerve regeneration (Schulte et al., 1997) . The flotillins are palmitoylated and myristoylated proteins, anchored to the plasma membrane and are considered to be exclusively raft localized (Schneider et al., 2008) . Flotillins belong to a larger class of integral membrane proteins that have an evolutionarily conserved domain called the prohibitin homology domain (PHB) which determines the affinity of proteins carrying it to the lipid rafts (Morrow and Parton, 2005) .