Statins are widely used and well-tolerated medications. Rosuvastatin differs from other HMG CoA reductase inhibitors in that only up to 10% of the parent compound is metabolized by cytochrome P450 2C9 and 2C19 and not by P450 3A4 [34] . As a result, it exhibits fewer drug-drug interactions, and serum concentrations are not affected by CYP2D6 gene polymorphism. Adverse events seen with rosuvastatin are generally mild and may include muscle symptoms, however, myopathy and rhabdomyolysis occur infrequently in patients taking 40 mg/day or less. As with other HMG-CoA reductase inhibitors, a dose-related increase in liver transaminases and creatinine kinase (CK) has been observed in small numbers of patients taking rosuvastatin. The overall occurrence of clinically significant transaminase increases is low (< 1%) and similar across rosuvastatin doses ranging from 5 mg/day to 40 mg/day [35] . Patients with severe liver disease may have increased exposure to rosuvastatin [35] .