Our results have shown high in vitro inhibition of RV by T. esculentum extracts, especially seed coat ethanolic extracts (0.01 to 0.001 mg/mL) and cotyledon ethanolic extracts (≥0.1 mg/mL), and tuber water extract (0.1 to 0.01 mg/mL). Mechanisms of antiviral action may include release of nitric oxide and may also interfere with viral cytopathic effects (as shown by moderate to high positive correlation between survival from rotavirus and release of nitric oxide), inactivation of RV (inhibition of virus replication or entry into cells may be responsible), possibly through interference with replication, and enhancement of tight junctions (though not directly related to levels of survival) (Figure 1 ). Our findings suggest that T. esculentum beans can be an important source of microbicides against RV. Further phytochemical characterization of T. esculentum extracts, identification of the responsible bioactive compounds, and the elucidation of other modes of action and quality standard studies are essential.