In this contribution we have shown that for the melanoma and prostate cancer datasets studied, the quantitative changes of Information Theory measures, Normalized Shannon Entropy, Jensen- Figure 19 . The stacked average gene expression of probes corresponding to BRCA1 and TERF2 (telomeric repeat binding factor 2) in True et al's prostate cancer dataset. The first group of samples (1 to 9 in green) correspond to Gleason 3 pattern, indicating that most of the samples in this group have no significantly reduced expression of this pair of genes. The second group of columns (10 to 21 in yellow) correspond to Gleason 4 patterns and the last 8 columns (22 to 29 in red) correspond to Gleason 5 samples. A very recent study by Ballal et al. have linked BRCA1, to telomere length and maintenance and its loss from the telomere in response to DNA damage [720] (see also [721] ). There is an increasing trend of dowregulation, so it would be interesting to evaluate if indeed this pair of proteins could be an early marker of dowregulation useful to evaluate samples with Gleason pattern 2, or if may constitute a biomarker useful to distinguish a prostate cancer subtype. doi:10.1371/journal.pone.0012262.g019