In general, MAC-associated IRIS typically presents with lymphadenitis, with or without abscess formation and suppuration [5] . Other less common presentations include respiratory failure secondary to acute respiratory distress syndrome (ARDS) [56] , leprosy [57] , pyomyositis with cutaneous abscesses [23], intra-abdominal disease [58] , and involvement of joints, skin, soft tissues, and spine [58, 59] .