Gene nomenclature standardization [1] , database efforts [2] [3] [4] , and phenotype ontology projects [5] in both human and mouse over the past decade have provided the foundation for integration of information on genetic contributions to disease and phenotypes. This allows the opportunity for systematic comparison and higher order systems analysis of disease and phenotypic information. In this report, we summarize and integrate large scale information on human genetic association information and mouse genetically determined phenotypic information with the goal of identifying fundamental relationships in human disease and mouse models of human disease.