Human disease caused by HPAI viruses can be characterized as acute viral pneumonia aggravated by ARDS, toxic shock and multiple organ failure. System dysfunction mediated by hypercytokinemia and high viral load [9] . To be ready for new influenza pandemy it is necessary to use animal models, in vaccine and antivirals studies, which most closely reflect human disease. Isolates from FRSI SRC VB "VECTOR" repository which were characterized previously were examined for MLD 50 , molecular markers of pathogenicity, sensitivity to amantadines and neuraminidase inhibitors, to be candidates for murine model. Among the investigated isolates A/duck/Tuva/01/06 has best features to be used.