Pulmonary TB is characterised by granuloma formation, caseation and ultimately cavitation, reflecting a complex interplay between distinctive components of the innate and acquired immune response and the pathogen [5] . Traditional serological analysis of single circulating proteins is notoriously unreliable for TB diagnosis [7] . In contrast, patterns of circulating proteins could provide an accessible readout of pathophysiological status. Discovery of such discriminatory biomarkers could open the way for the development of new point-of-care tests based on a lateral flow format such as dipsticks.