The role of betaine in the treatment of NASH has been evaluated in human studies. Oral administration of betaine glucuronate in NASH patients for 8 weeks reduced both hepatic steatosis by 25% and hepatomegaly by 8%, and it significantly attenuated serum concentrations of AST, ALT, and glutamyl transferase. Similarly, a marked improvement in the degree of steatosis, necroinflammatory grade, and stage of fibrosis was obtained after treatment with betaine [69] .