Our study suggests that influenza A(H1N1)pdm09 burden in Argentina was similar to that elsewhere and caused a large number of deaths, hospitalizations, and cases of ILI. Indeed, the majority of decedents with a history of ILI identified during the pandemic tested positive for influenza A(H1N1)pdm09. Influenza-associated mortality and hospitalization rates were similar to those elsewhere and to those of Argentina during seasonal influenza epidemics. Such findings suggest that it may be prudent to examine interventions used during the pandemic to determine their potential value to prevent and mitigate Argentina's annual seasonal influenza burden.