Patients irresponsive to the IST are prone to be cured by unrelated donor bone marrow transplantation [18] . Immunosuppressive therapy might have proved as a safe and alternative treatment for HAAA after of bone marrow or haemotopoietic stem cell transplantation [55] . Several studies showed that Parvovius induced aplastic anemia improves by the administration of retroviral therapy [21, 56] . Antiviral therapy for treating hepatitis B associated HAAA has been unknown yet; however it has been tested by administrating the nucleoside analogs, lamiviudine, against the aplastic anemic secondary to hepatitis B virus infection and remission occurs from the severe aplastic anemia accompanied with the hepatitis B viral infection. Interferon, an effective therapy for the hepatitis B and C viral infections, cannot be employed as a potential approach for the HAAA because of its mylosuppressive effects [21] . Acyclovir has been used for the treatment of aplastic anemia caused by the Epstein Bar virus [32] . The blood count comes to the normal range after five years of treatment [55] , however, chances of recovery from hepatitis associated acquired aplastic anemia is rare [57] .