Method: In database of neurosurgery biopsies from 2002 to 2011 two cases of ISCM were found without preoperative signs of primary neoplasm. Surgically removed tissue was stained with hematoxylin-eosin and immunohistochemically using following markers: AE1/ AE3, CK7, CK20, mammaglobin, TTF-1, GFAP, S-100 and vimentin. Results: One patient was male aged 51 and another female aged 44. They presented with neck pain and rapidly progressive upper and lower limb weakness. Imaging analysis showed contrast-enhancing mass at the level C4-C6 in male and C2-C4 in female, reported as an ependymoma. Grossly, tumor tissue was of soft consistency and grey white color with yellowish foci of necrosis. Histopathology revealed moderately differentiated adenocarcinoma with distinct border to surrounded glial tissue. In both cases, tumor cells were immunopositive for AE1/AE3, CK7 and TTF-1 indicating primary lung origin. Postoperatively primary cancer was found in upper lobe of the left lung in both cases, without evidence of lymphadenopathy and other distant metastatic lesions in female.