Then the fixed effect model was applied to synthesize the data and the pooled OR was calculated. The pooled OR value was significant at 0.84 (95% CI = 0.73-0.96, p = 0.01, Figure 2B ). The Bonferroni corrected P-value was 0.05. These results suggested that the 5-repeat allele carriers tended to be associated with resistance to HIV-1 infection in HIV-1 exposed seronegative (HESN) individuals.