In the ROC analyses of the 17-urine-peptide biomarker panel for discriminating SJIA F versus QOM/RD or SJIA F versus KD/FI, bootstrapping (a re-sampling technique) was used to avoid bias due to the presence of outliers in our assayed samples. In both cases shown in the ROC plots, the ROC analyses (Figs. 2 and 3c) yielded a significant AUC, indicating the ROC curve was not affected significantly by the bootstrapping process and demonstrating the robustness of our 17-urine-peptide biomarker panel in discriminative analyses.