The first issue that we will discuss as a group is whether it is a solid or a cystic lesion of the pancreas that we are dealing with. In this topic the surgeon will underline the importance in this differential diagnosis, since a solid lesion must be resected, if possible, where some cystic lesion could be followed up. In this settings, the pathologist will illustrate us the different pathological patterns of pancreatic neoplasms, cystic and solid, their immunohistochemistry and the possible progression from benign to malignant pancreatic tumour. According to the different pathological patterns, the radiologist will illustrate the appearance on the different pancreatic tumours on the different diagnostic imaging modalities. The second issue that we will collegially discuss is whether we are sure that it is a neoplasm. The surgeon will illustrate the different surgical procedures that he/she is able to perform and the relative indication and the different questions that each procedure need to be answered by the pathologist and the radiologist. The pathologist will show the different pathological patterns that are useful for the differential diagnosis among different pancreatic tumours and especially the criteria useful for the differential diagnosis with tumour-like conditions that do not require surgery but medical therapy instead. The radiologist will illustrate the diagnostic imaging signs that are helpful to make a differential diagnosis in patients with a mass in the pancreas. Learning Objectives: