IHC is less expensive and easy to perform but is prone to a high rate of inaccuracies due to variations in tissue preparation, protein stability, antibody sensitivity and scoring subjectivity. On the other hand, FISH is accurate with good clinical correlation but it is expensive, time consuming, and labor intensive and requires very experienced personnel. Therefore, suggestions have been made to use a combination of IHC and FISH, where IHC is used as a screening procedure followed by a FISH confirmation if necessary (46, 47) .