We used an SCT approach to construct our peptide vaccine candidates. With this method, peptides are able to specifically bind to the peptide-binding cleft created by the HLA-A*0201 a-1 and a-2 domains, and this phenomenon can imitate the natural binding of peptides onto the MHC class-I molecules during normal antigen processing [12] . Also the SCT system ensures the stability of the MHC I-peptide complex after translation [29] , and a more precise and direct priming of the professional antigen presenting cells to the cytotoxic T cells is achieved. Hence the stimulating efficiency of the peptide vaccine can be greatly maximized [2] .