The naturally occurring (1-4) nucleotide (nt) deoxyribose-Inosine (dInosine) is one of many more or less generally hybridizing nt (5,6) known as universal bases. All four normally occurring DNA bases can hybridize to dInosine. The general trend in decreasing hybridization stability is I:C > I:A > I:T & I:G > I:I when using 1 M NaCl, 10 mM sodium cacodylate and 0.5 mM EDTA pH 7 (7, 8) . However, dInosine is readily available and can be recognized as a G by polymerases (5, 9, 10) . Alternative universal bases, e.g. 5-nitroindole, also exist.