Since the reported cases are not specified according to age, the estimate will be done on a population basis. Typical symptoms of Hepatitis E include jaundice (yellow discoloration of the skin and sclera of the eyes, dark urine and pale stools), anorexia (loss of appetite), an enlarged, tender liver (hepatomegaly), abdominal pain and tenderness, nausea and vomiting, and fever and the disease may range in severity from sub-clinical to fulminant [35] . To calculate the YLD, we will set the disability weight to that for a diarrhea disease episode, (equal to 0.11, [33] ), in untreated or treated form.