A very recent study by Ballal et al. have linked BRCA1 to telomere length and maintenance and its loss from the telomere in response to DNA damage [720] (see also [721] ). We have previously mentioned that BRCA1 is a conspiquous biomarker arising from the analysis of True et al.'s dataset using our methods. We found this to correlate with a preivous study that showed that BRCA1 has a reduced expression in immortalized prostate epithelial cells before and after their conversion to tumorigenicity [493] . We also mentioned that the knockdown of BRCA1 leads to anaccumulation of multinucleated cells [492] , preserving chromosomal stability [490] . Ballal et al. telomeric ChIP assays to detect BRCA1 at the telomere and reported time-dependent loss of BRCA1 from the telomere following DNA damage. Due to the role of telomeres in maintaining chromosomal stability [722] and the inverse correlation of telomere length and divergent karyotypes in prostate cancer cell lines [723, 724] (as well as the recognized role of telomere dysfunction in the induction of apoptosis or senescence in vivo [725, 726, 727, 728, 729, 730] , increase of mutation rates [731] , DNA fragmentation [732] , and their relation with DNA damage signalling [733] ), we checked for other probes of genes involved in telomeric function.