PMF_Score also provided reliable poses that were ranked best by D_Score. It yields 19 actives in the top 1% of the ranked list. However, it failed to rank any sensible docking poses regardless of what poses were extracted by itself or by the other scoring functions. Thus, for the BACE-1 target, PMF_Score appears to be more capable of accurately docking and correctly identifying the true binding mode, but the disadvantage of PMF_Score is the enrichment of active compounds.