Global expression profiling during epileptogenesis allows a greater understanding of the broad mechanisms underlying the epileptic process. It demonstrates specific genomic changes operating in concert with the entire molecular environment, thereby opening the doors to further research into possible causative pathways and functions through gene ontology annotations of cellular components, biological processes and molecular functions. In addition, the availability of large-scale libraries produced using uniform protocols allows the comparisons of commonality genes within other disorders apart from epilepsy potentially identifying reactive general genomic changes, shared pathways of action or specific causative genes. There is also the potential for discovery of novel genes not previously described with SAGE resulting in new hypotheses and theories into the pathogenesis of epilepsy as well as the potential to guide new therapeutic treatments in epilepsy as well as other disorders, neural or non-neural.