By multivariate analysis, gain of MYCN was selected as an independent predictor of OS in this CLL cohort (HR: 4.79; 95% CI 1.31-17.39; P 5 0.017), along with 17p13 deletion (HR: 2.28; 95% CI 1.01-5.15; P 5 0.045), age > 70 years (HR 3.89; 95% CI: 1.88-8.05; P < 0.001), and Binet stage B-C (HR: 3.31; 95% CI 1.55-7.06; P 5 0.002) (Table III) .