Objective: Gallstone disease remains a serious problem of modern surgery. An important aspect of the problem is the question of the urgency of surgical intervention, depending on the condition of the gallbladder. Method: It was carried out the analysis of 1130 case histories and excised gallbladder with different forms of cholelithiasis. 81.3 % were women in the age of 41-50 years. Acute catarrh cholecystitis was found out in 20 % cases, acute phlegmonousin 21 % cases, acute gangrenous -in 11 % cases, chronicin 28 % and chronic relapsingin 21 % cases. Results: All forms of cholecystitis characterized by a maximum thickness of the body wall, minimal at the bottom of the gallbladder. In all forms adipose tissue inflammation in the connective tissue layer was increased and it was found out the atrophy of the mucosa. In the inflammatory infiltrate in acute forms of inflammation were found neutrophilic and basophilic leukocytes: with simple acute cholecystitis -in the bottom, and with acute phlegmonous and gangrenous cholecystitis -in the area of the body of the gallbladder. In the cases with chronic cholecystitis were dominated mononuclear cells in all areas, and in the cases with chronic relapsing -neutrophilic and basophilic leukocytes in the bottom and the body, and mononuclear cells -in the neck of the gallbladder.