Objective: Glomerulocystic kidney disease (GCKD) is a rare condition usually congenital and reported in infants and young children. Only few cases of adquired GCKD had been reported often following Hemolytic Uremic Syndrome (HUS). Method: Histological study of two kidney graft explants. Results: We present two cases of kidney transplant who developed HUS in allografts. Both cases showed at the histological examination typical vascular and glomerular changes of Thrombotic Microangyopathy (TMA). A cystic transformation with increase of urinary space and retraction of glomerular tuft was frequently observed. Chronic transplant vasculopathy was found in the two cases. Humoral active rejection was also demonstrate in one case with moderate peritubular capillaritis and glomerulitis and diffuse C4d deposition at peritubular capillaries. Conclusion: In a few cases GCKD appear to develop after another kidney disease includes single case reports of GCKD associated with mesangial glomerulonephritis, Wegener's granulomatosis, progressive systemic sclerosis, after HUS (include some case in adult patient). Our two cases represent a initial stage of adquired GCKD. The ethiopathogenetic relationship is not clear but some authors propous that cystic dilatation of the Bowman's capsule associated to TMA/ HUS may be secondary to ischemic mechanism.