Accuracy of classifier serum proteins in prediction of leptospirosis (FC) was also tested ( Figure 5 ). Although Apo A-I (AUC = 0.783; 66.6% sensitivity and 90% specificity at a threshold value .111.1 mg/dL) exhibited fine proficiency in detection of leptospiral infection; performance of haptoglobin (AUC = 0.508; 66.6% sensitivity and 50% specificity at a threshold value .0.845 g/L) and retinol-binding protein (AUC = 0.558; 50% sensitivity and 65% specificity at a threshold value .34.99 mg/ mL) were poor (Table S9 ). ROC analysis revealed that the serum levels of the classifier proteins, particularly Apo A-I and haptoglobin exhibited good correlation with plasmodial infections and could further be investigated as potential surrogate protein markers for malaria.