The paradigm that I employ is as follows: ‫ع‬ Expected and natural clinical presentation and epidemiologic circumstances ‫ع‬ Unexpected but natural clinical presentation and epidemiologic circumstances ‫ع‬ Unexpected and unnatural clinical presentation and epidemiologic circumstances Let me illustrate by providing examples of the three clinical presentations of anthrax in humans: cutaneous; gastrointestinal; and inhalational.