Silencing of eEF1Bc expression in N. benthamiana also reduced the accumulation of the unrelated TMV (Figure 8 ), which belongs to the alphavirus-like supergroup. These data suggest that eEF1Bc is likely involved in TMV replication, which also contains a highly structured 39-end [54] . Therefore, it is possible that eEF1Bc is co-opted by different plant RNA viruses, and possibly other RNA viruses as well.