To date, several institutions have attempted to discover variants for glaucoma by conducting a GWAS, and a few published studies have reported the association of particular loci with POAG using Caucasian subjects (Table S5) . Thorleifsson et al. reported the association of common variants near CAV1/CAV2 on 7q31.1 using a population of European ancestry [13] . In contrast, Kuehn et al. reported that they failed to replicate their results in a United States cohort [15] . Moreover, meta-analysis of the association results derived from several institutions of Northern Europe, including the data from Thorleifsson et al. [13] , identified a few new loci associated with POAG, including the CDKN2B-AS1 locus on 9p21.3 [17] . Recently, the new loci at TMCO1 on 1q24.1 and CDKN2B-AS1 were reported to be associated with Australian populations [14] . Thus far, only the association of the CDKN2B-AS1 locus was replicated, even within the same ethnicity of European descent. Interestingly, Thorleifsson et al. also showed a modest association with the CAV1/CAV2 locus using Chinese subjects [13] , although the allele frequency of the particular variant in Asian subjects was quite low when compared with that in Caucasians, suggesting etiological differences due to the genetic background. In fact, according to the results of our Present GWAS for POAG, we were unable to replicate the association with the CAV1/CAV2 and TMCO1 loci ( Figure S5F , G, Table S5 ). Moreover, in the Present GWAS, we were unable to replicate the association results of the 6 SNPs identified in the previous study [10] (Table S5) , even though the populations were of the same ethnic background, thus suggesting that we still need to discover authentic variants, irrespective of the difference in ethnicities, to elucidate the complex etiology of glaucoma. Consequently, it should be noted that the variants identified in the CDKN2B-AS1 locus in this study using a Japanese population seemed to be shared with the Caucasian subjects (Table S5) , thus showing that we have successfully obtained one of the authentic variants for POAG that is not ethnicity related.