We have investigated histologically testis of 63 died patients aged 36-89 with general atherosclerosis and testis of 38 men aged 36-89 with minimal manifestations of atherosclerosis died in an accident. Results: The absolute volume rete testis of patients being ill with atherosclerosis decreases by 65-80 %. Absolute volume of convoluted seminiferous tubules and interstitial tissue decrease by 24-27 %. In testis there are zones of focal sclerosis of seminiferous tubules, whose area goes as far as 12.7 % of shear section area. It was revealed that on the periphery of sclerosis zones there is a reduction of transaction area of seminiferous tubules by 20-33 % with Sertolli cells quantity reduction by 17-24 %. It has been stated the downward changes in index of spermatogenesis in convoluted seminiferous tubules by 63-65.6 %, accounted for the quantity reduction of all kinds of cells. Conclusion: Morphological changes of testis at general atherosclerosis characterize atherosclerotic testiculopatie, caused by chronic ischemia of testis.