Results: 62-year-old woman developed severe neurological symptoms and progressively decreased consciousness. CT revealed cystic tumor in cerebral peduncle and medulla oblongata. Stereotactic biopsy revealed metastasis of carcinoma. The patient died from of the twelfth day after STB because of recurrent hemorrhage. Autopsy revealed well-differentiated papillary adenocarcinoma in the head of pancreas and with multiple metastases in liver and two metastases in medulla oblongata and cerebral peduncle. IHC staining for cytokeratins 7, 18 and 19, mucin 1 and 5 AC types was strongly positive. Ki67 labeling index was 14 %. Conclusion: We reported an autopsy case of brain metastases from pancreatic cancer, in which the patient initially developed symptoms of a neurologic disorder without exhibiting any symptoms of pancreatic disease.