From the experience here reported, we can state that, with a close cooperation between different specialists (intensivist, cardiologist, cardiac surgeon, nurse, perfusionist), an ECLS Service can be started over a relatively limited period of time, achieving a high level of efficiency. Our model of ECLS team has allowed us to start extracorporeal support in different hospital scenarios, such as ICU and Emergency Room. This feature of flexibility and adaptability of our ECMO system has made it particularly beneficial during the Influenza A pandemic, making this resource available also in peripheral hospitals.