protein coding, Y > G is associated with allergic asthma [40] a , poor outcome in oral squamous cell carcinoma tumours [146] , C over represented in helminth infected Ugandans [148] rs12147890 A/G protein coding rs2233860 G/C 3' UTR,G is correlated to higher intracellular ECP [143] , G is associated with allergic rhinitis [145] , a rs8019343 A/T 499G > C, 562G > C 3' UTR T is only present in one patient with helminth infection [147] Polymorphisms found in the ECP gene and surrounding chromosomal sequence. Listed are Polymorphism i.d.'s, altered bases, alternative names, and types of associations a) C-G-G haplotype associated with allergic rhinitis [144] [148]. Interestingly, from the -550 polymorphism over a stretch of 272 bases to the mRNA transcription start site, thirteen polymorphism sites are located (NCBI Reference Sequence: NC_000014.7, J. Bystrom unpublished observation). Similar to the protein coding region and the 3'UTR, this region is highly homologous to the RNASE2 gene region, with the only differences being the sites of the polymorphisms. The replacement base's for twelve of the thirteen polymorphisms is to the same base as in the RNASE2 promoter sequence. This is also the case for two of the 3'UTR polymorphisms. This further highlights the extremely close relationship between RNASE3 (ECP) and RNASE2 (EPX/EDN).