1. a multilevel ecosystem approach, involving cross-scale integration. 2. incorporated ecological theory and data for the specific disease system, 3. local scale intervention using a participatory approach that matches pathogen management with sustainable development across ecosystem and institutional scales. Globalization and emerging governance modalities This paper explores the possibilities for global governance effectively dealing with the international transmission of disease. First, zoonotic regulation and control pose a special case for public health agencies, and this paper proposes a propositional model for an effective public health stance. Second, globalization dynamics are briefly reviewed in terms of an emerging consensus on the need for global governance in public health. Third, a brief examination of global governance modalities suggests that a strong global governance case has distinct limitations (despite its possible justification); an exploration of contemporary directions in global governance follows. Finally, the paper examines the phenomenon of contemporary zoonotic control within the conditions of an effective regulatory regime. The global governance of zoonoses presents a special case for global public health. The structural framework and dynamics of public health define the parameters of how emerging mechanisms of global governance are likely to influence the control of zoonoses. I begin this paper with a review of some of the endemic tensions that exist within efforts to extend public health into a global framework. I then discuss how the dynamics of contemporary globalization influence the transformation of both social and governmental behavior. I review the notion of "regimes" of governance that embrace trans-national and supra national entities. Finally, I inquire about the conditions for an effective regime for zoonoses control via global governance.