Methods: A PMS questionnaire which was based on the DSM-IV-TR criteria for PMDD, a screening for somatic symptoms (SOMS, Rief 2008) , and the German version of the CES-D (Radloff, 1977) were presented online. In a prospective design, questionnaires were presented at baseline (t1) and at a second assessment (t2 Objective: To examine predictors of treatment outcome in IBSpatients who participated in a randomized controlled trial in primary care, where 149 IBS-patients were randomised to mebeverine hydrochloride (n=77) or mebeverine+cognitive behaviour therapy (CBT) (n=72). CBT offered additional benefit over mebeverine alone. Methods: Regression analyses were used to identify predictors of work and social adjustment (WASA) 12 months after treatment ended. The intervention groups were analysed separately in order to look at the separate effects in each group. Results: Lower levels of psychological distress (anxiety and depression) at baseline predicted a good outcome in the mebeverine group (β=0.388 (95%CI: 0.065-0.936), p-value= 0.025) but not in the mebeverine+CBT group. In the adjusted model for the mebeverine+CBT group less adaptive IBS related behavioural coping predicted a good outcome (β=0.285 (95%CI: 0.002-0.210), p-value=0.045). Conclusion: Different factors are associated with outcome depending on the treatment received. At assessment clinicians should assess patients coping styles and may want to consider recommending CBT to those patients with IBS in primary care who are engaging in unhelpful coping behaviour. Background: In Norway, the majority of medically certified sickness absence is granted for musculoskeletal complaints and mental disorders. The challenge for the general practitioners (GP)