There have been a range of studies that have now investigated the viral antigen capid-incorporation strategy as a viable means to improve vaccination in many disease or infection contexts [4, 14, 15, 17, 18, 21] . Due to the controversial HIV STEP trial and the continuing HIV epidemic, some groups have employed the antigen capsid-incorporation strategy to make strides against HIV/AIDS by attempting to make a safe and effective HIV vaccine [41, 42] . The main vector systems that have been utilized to derive a HIV vaccine include human rhinovirus (HRV) and Adbased vector systems [43] . With respect to the HRV system, researchers have constructed HRV:HIV chimeras in an effort to stimulate immunity against HIV-1 [44] . Furthermore or along these lines, in an effort to develop HIV vaccines researchers within this same group have generated combinatorial libraries of HRV capid-incorporated HIV-1 gp41 epitope. Their results indicate that they have been successful in eliciting antibodies whose activity can mimic the 2F5 effect [45] .