It is of interest that systemic amyloidosis of AA type was induced in most of the SJL/J mice immunized with PDC-E2 but not in controls with a-casein. Generally, AA type amyloidosis occurs secondary to systemic chronic inflammatory changes such as rheumatoid arthritis and tuberculosis. Heretofore, AA amyloidosis in mice has been previously induced in a number of strains of mice by repeated injections of a-casein, chemicals and endotoxin (Skinner et al., 1977; Baumal, 1979; Rokita et al., 1989; Kisilevsky and Young, 1994; Sipe, 1994) , and in a transgenic mouse model carrying human IL-6 gene with mouse metallothionein-I promoter (Solomon et al., 1999) . Spontaneous amyloid deposits have also been noted in aged SJL/J mice. In fact, the injection of amyloid enhancing factor (AEF) together with a-casein in CFA induced AA amyloidosis in SJL/J mice, while a-casein alone did not induce amyloidosis (Rokita et al., 1989) . Our findings are in agreement with these findings but not those of Jones et al. (1999) .