The hMAbs from donor 013 displayed variable neutralization properties ( Figure 3A -C), with 2 non-neutralizing hMAbs (DV1.6, and 21.5; 50% neutralization titers .1 ug/ml) , 4 weakly to moderately neutralizing hMAbs (DV14. 21, 35.3, 25.5 and 18.21 ; 50% neutralization titers between 0.1 and 1 ug/ml) and 4 strongly neutralizing hMAbs (DV3.7, 10.16, 13.6 and 23.13; 50% neutralization titers ,0.1 ug/ml). The strongly neutralizing hMAbs, including those that were cross-reactive in binding assays, neutralized DENV2 better than the other serotypes ( Figure 3) . Thus, by biasing the initial screen for hMAbs that bound to rE protein, we identified hMAbs with neutralization profiles that were more similar to the immune sera of donor 013, which strongly neutralized DENV2.