Medication, drug, radiation and tobacco exposure Drugs used in inflammatory or cancer pediatric diseases can cause ILD. They include anti-inflammatory agents (e.g. aspirin, etanercept), immunosuppressive and chemotherapeutic agents (e.g. azathioprine, methotrexate, cyclophosphamide), antibiotics, cardiovascular agents, and, for teenagers, illicit drugs [99, 100] . There are no distinct clinical, radiographic or pathologic patterns, and the diagnosis is usually made when a patient is exposed to medication known to result in lung disease, with a timing of exposure appropriate for disease development and elimination of other causes of ILD. Treatment relies on avoidance of further exposure and corticosteroids in markedly impaired patients.