Computer-based simulations provide an additional instrument for emerging infectious-disease preparedness and control, allowing the exploration of diverse scenarios and the evaluation of the impact and efficacy of various intervention strategies. Here we have presented a computational tool for the simulation of emerging ILI infectious diseases at the global scale based on a datadriven spatial epidemic and mobility model that offers an innovative solution in terms of flexibility, realism, and computational efficiency, and provides access to sophisticated computational models in teaching/training settings and in the use and exploitation of large-scale simulations in public health scenario analysis.