Method: The study included 46 patients diagnosed with breast carcinoma from Baku Oncology Hospital during the 2001-05. After whole slide scanning by Mirax scanner (3DHistech, Budapest) of HE, Ki67 and phh3 stained slides we juxtaposed all three slides in one screen to the found area with maximal ki67 level in tumor and the corresponding area in other slides. Morphometric analysis was performed using the Pannoramic Viewer software (3DHistech, Budapest). For each case we analyzed a total number of tumor cells in1 mm2, number of Ki67 and phh3 positive cells. Results: Mean tumor cells in 1 mm2 of histology slide was 4180+\\−251 cells, median -3976 cells, 1185+\\−166 (31 %) were positive for Ki67 and 124+\\−23 (3 %) were in mitosis. There was moderate correlation between cell density and Ki67 r=0,44 (p=0,0032) and phh3 r=0,42 (p=0,0018). Conclusion: By analysis of breast cancer, was established a total tumor cell per mm2 and main proliferative characteristics for invasive ductal carcinoma. Objective: Adenomyoepithelioma of the breast is a very rare benign tumor with biphasic proliferations of epithelial and myoepithelial elements. It is morphologically and immunohistochemically identical to epithelial-myoepithelial cell carcinoma of the salivary gland. The histologic criteria of malignant AME is not well-established because of the rarity of AME. We report a case of malignant adenomyoepithelioma in a 65-year-old woman. Method: On ultrasonography, a well-marginated and lobulated solid mass was found at LIQ of the right breast.. An ultrasono-guided core biopsy was performed. The diagnosis of core biopsy was myoepithelial lesion. She subsequently underwent a wide local excision of the lesion. Results: Microscopically the tumor mass was composed of biphasic patterns which showed formation of tubules lined by an inner layer of ductal epithelial cells surrounded by proliferation of myoepithelial cells that also formed solid nests. But this tumor had foci of infiltrating margins and proliferation of spindle cell components. Also noted are numerous mitotic figures and increased mylepithelial Ki-67 positivity (10-15 % of tumor cells). Conclusion: Breast lesions which have predominently myoepithelial cells can be divided into myoepithelial hyperplasia, adenomyoepithelioma and malignant adenomyoepithelioma. Tavassoli divied AME into tubular, papillary, and solid subtypes. The criteria of malignant AME is not wellestablished but some criterias can apply to make a diagnosis of malignant AME. Objective: Neoadjuvant chemotherapy (NACT) is available for patients with breast carcinoma. However, resistance to chemotherapy is still a main cause of mortality. Method: Differentially expressed genes were identified from previously published studies that examined chemoresistant and chemoresponsive cell lines or patients with breast carcinoma. The expression of 14 selected gene products was assessed in tissue microarray slides comprising 75 post-NACT resection specimens from breast carcinoma patients using immunohistochemistry, and analyzed according to the molecular subtype and Residual Cancer Burden (RCB) grade. Results: Most cases were positive for ABCB1 (97.7 %) and MYC (96.0 %), but negative for TOP2A (100 %). RCB-II cases expressed much higher levels of MUC1 (p=0.011) and CLU (p=0.021) than RCB-III cases. Positive expression for CALR (p=0.002) and LGALS3 (p=0.018) was observed more often in triple negative types than in luminal types, and cytoplasmic CDKN1B expression was observed more often in luminal types (p=0.014). Conclusion: Positive expression of ABCB1 and MYC and negative expression of TOP2A in the residual carcinoma after NACT implies general resistance to NACT. Expression of CALR, LGLAS3 and cytoplasmic CDKN1B may be associated with resistance depending on the subtype. Expression of MUC1 and CLU can be used to predict the RCB grade or response to NACT.