Future studies of allo-SCT in MM should focus on regimens that are less toxic but able to preserve anti-tumor effects such as radioisotopes linked to antibodies that target myeloma cells or other marrow-based cells. It should be relatively easy to combine targeted radiotherapy with a non-myeloablative regimen to create a more tolerable cytoreductive protocol. It is also worth reconsidering more myeloablative regimens, as supportive care has improved greatly in the past 20 years. As previously noted, when younger patients are transplanted earlier from initial diagnosis, TRM is reduced.