Background/Aims: Angiogenesis plays a significant role in the metastasis and recurrence of hepatocellular carcinoma (HCC). Placental growth factor (PlGF), which is one member of the vascular endothelial growth factor family, may have prognostic values in patients after curative resection of HCC. Methods: Expression of PlGF was assessed by immunohistochemistry in tissue microarray containing paired peritumoral liver tissue and tumor from 105 patients underwent hepatectomy for histologically proved HCC. Prognostic values of PlGF and clinicopathological factors were evaluated. Result: PlGF staining was mainly on the cytoplasm of tumor cells or hepatocytes. The mean integrated optical densities of peritumoral and intratumoral density of PlGF were 0.018±0.018 and 0.006±0.007 respectively. Peritumoral PlGF density was significantly higher than that in tumor (p<0.001), and this result was also validated in another cohort of 37 patients by quantitative real-time reverse transcription-PCR (p=0.007). Intratumoral density of PlGF was not correlated with common clinicopathological factors (eg, TNM stage, tumor size, microvascular invasion, intra-hepatic metastasis) or overall survival (OS) (p=0.425) and time to recurrence (TTR) (p=0.419). However, peritumoral density of PlGF, which was correlated with tumor size (p=0.003) and intrahepatic metastasis (p=0.004), was a prognostic factor for both OS (p=0.015) and TTR (p=0.018). In multivariate analysis, peritumoral expression of PlGF was also an independent prognostic factor for OS (p=0.015, RR: 2.500 95% CI: 1.191-5.253 ) and TTR (p=0.045, RR: 2.013 95% CI: 1.014-3.996). Conclusion: Peritumoral expression of PlGF in HCC patients is an independent risk factor for survival and recurrence, and may be a target of anti-angiogenic therapy in preventing post-operative recurrence. Purpose: To further research RFA in combination with hepatic artery-portal vein chemotherapy and ethanol injection for treatment of advanced hepatocelluar carcinoma (HCC). Methods: 25 cases were treated with transhepatic artery chemoembolization (TACE) + radiofrequency ablation (RFA) + introportal vein chemotherapy (PVC) + percutaneous ethanol injection (PEI) (four combined group) and this method was compared with 23 cases that were performed TACE + PEI (two combined group) . The serum level of AFP was measured respectively after 2 and 6 months, CT scan and color Doppler ultrasound were measured after treatment for six months.