The eligible investigations met the following criteria: (1) the studies were case-control designed to explore the association between VNTR polymorphism in the DC-SIGNR gene and HIV-1 susceptibility; (2) the studies provided data on the distribution of VNTR polymorphism in the case-control population; (3) the studies were published in the English or Chinese languages. Studies were excluded if they did not contain enough data for meta-analysis, if they were abstracts or reviews, or if they were duplicated within other included studies.