The association of E5564 with plasma protein and lipoprotein was studied in plasma obtained from fasted human subjects with various lipid concentrations (64) . It was reported that the majority of E5564 was recovered in the high-density lipoprotein (HDL) fraction. Additionally, they had shown increasing levels of TG-rich lipoprotein (TRL) lipid (TC and TG) concentrations resulted in a significant increase in the percentage of E5564 recovered in the TRL fraction. Furthermore, their findings had suggested that E5564 does not influence CETP-mediated transfer activity (64) .