The relevance of these genetic variants in the severity of CAP was also evaluated by analyzing predisposition to acute respiratory distress syndrome (ARDS) and to multiorgan dysfunction syndrome (MODS) (see Tables 5 and  6 ). The SFTPD aa11-C allele was significantly overrepresented in patients with MODS or ARDS. Haplotypes 6A and 6A-1A, were also associated with the development of ARDS, and SFTPA2 1A and 1A 10 were associated with the development of MODS. For the observed odd-ratios, the power of the association of 1A with predisposition to MODS was 89.29%. However, the number of individuals included in the analysis of outcome was relatively small and the power of the tests with a significance level of 1% was lower than 80%. These associations remained significant in multivariate analysis adjusted for age, gender, hospital of origin and co-morbidities, as well as for hospital of origin, PSI and causative microorganism (see Tables 5 and  6 ). By contrast, 6A 3 -1A 1 was associated with protection against MODS, although this difference was not significant in the multivariate analysis.