Numerous neurotransmitter signaling systems, especially receptor function, are influenced by lipid rafts. The range of receptors involved is all-encompassing, including ionotropic receptors such as α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA receptors), γ-aminobutyric acid (GABA) receptors, Nmethyl-d-aspartate (NMDA), and nicotinic acetylcholine (nACh) receptors. The influence of lipid rafts also extends to metabotropic G-protein coupled receptors, such as the muscarinic acetylcholine receptor (mAChR; Allen et al., 2007; Rushworth and Hooper, 2011) . Although all these signaling systems can be linked to AD, it is the cholinergic system which is of central importance, as its hypofunction is considered one of the hallmarks of the disease (Coyle et al., 1983; Auld et al., 2002; Schliebs and Arendt, 2006) and its involvement is therefore principally considered here.