screening if they did not have symptoms (p=0.04). Treatment of obesity-related co-morbidities may take precedence over cancer prevention in primary care. Messages which focus on prevention and screening benefits may improve healthy behaviors in obese women. This study investigated whether differential framing of CRC risk and Fecal Occult Blood Test (FOBT) information impacted upon cancer attitudes and screening behaviour. N=660 people 50-71 years were assigned to one of 6 intervention groups. They completed a laboratory-based survey measuring cancer attitudes. After reading information about CRC risk statistics (positive or negative framing, two-level variable) and FOBT advantages, disadvantages, or both/balanced (three-level variable), attitudes were re-measured. Participants were given a card to request a free FOBT kit. Return of card within 7 days was measured as intention to screen, and return of completed kit within 35 days was measured as screening uptake. Results were analysed using Chi-square statistics and repeated measures ANOVA to examine the influence of information provision, in its different forms, on attitudes to CRC screening. From pre-intervention to post-intervention, risk perception scores increased (F(1,448) = 18.24;p<0.001), and optimistic bias decreased (F(1,654) = 14.50; p<0.001). Powerful others locus of control increased (F(1,654) = 11.22; p<0.001), as did Chance locus of control (F(1,654) = 29.25;p<0.001). There were no treatment effects for any of these variables. There was no significant difference for intention to screen between the CRC risk information frames or FOBT information conditions. For screening uptake, there was a significant difference between intervention groups (X 2 (5) = 13.167;p<0.05). Data partitioning indicated that there was no difference between FOBT uptake for the CRC positive risk information group by FOBT information condition. There were differences between CRC negative risk information group conditions (X 2 (2) = 11.316;p<0.01). Significantly more participants in the FOBT 'advantages' condition screened than those in the FOBT 'disadvantages' condition (x 2 (1)=3.85; p<0.05) or the 'balanced' condition (X 2 (1) = 11.001;p<.0001).