Signature peptides may be used as targets for antibody or ligand binding and may be developed for use in detection, therapeutics or vaccines (12, 13) . Since the signature regions are highly conserved within a species, it is likely that they are functionally important to the organism's survival or reproduction. Those signatures that land on or near protein active sites may be developed into therapeutics, since antibody or ligand binding may interfere with protein function. Signature regions may even be considered as vaccine targets, since these unique peptides may evoke a specific response in the host (14, 15) .