In November 2006, a cluster of six measles cases was reported amongst adolescents and young adults attending a professional school in the outskirts of Rome (attack rate 0.7%). The infection subsequently spread outside the school and cases continued to be reported amongst the Italian ethnic population until the summer 2007. This second outbreak reached a peak in March 2007 and was considered over only in August 2007 (Figure 1 ). During July-August 2007 three measles cases were notified per month, bringing the incidence level to that reported in the Lazio region before the described outbreaks (≤4 cases per month, or <1/100,000 population per year).