In addition to BACE1, it was shown that the subunits of the γ-secretase complex are also enriched in the lipid rafts (Lee et al., 1998; Hur et al., 2008) and that S-palmitoylation plays a role in localization and stability of nicastrin and Aph-1 within the rafts although not affecting the γ-secretase processing of APP (Cheng et al., 2009) . While caveolin-1 was shown to be an important regulator of γ-secretase spatial distribution and activity (Kapoor et al., 2010) , the proteins of the γ-secretase complex, e.g., PS1, in turn, can induce lipid raft formation and decrease the membrane fluidity . A subset of proteins, in particular voltage-dependent anion channel 1 and contact in associated protein 1, are also associated with γ-secretase in lipid rafts and affect APP processing (Hur et al., 2012) .