On the other hand, binding without any concomitant gain of regular secondary structure, has been also reported. This is the case of the unfolded proteins 4E-BP1 (4E binding protein 1), an inhibitor of translation. Its binding to eIF4E does not involve any transition to stable regular secondary structure (Fletcher et al. 1998) . Interestingly, when eIF4E binds to another partner, namely eIF4G, it induces a coil-to-helix transition in the latter (Marcotrigiano et al. 1999) , highlighting the diversity of the structural transitions that can be triggered by a structured partner.