The best-scored pose was always used to represent the plausible binding mode of a particular compound. In many cases, the pose varied from one to another as dictated by the separate scoring functions. Inspection of each scoring function in Table 1 indicated that the quality of the extracted poses is similar. No single scoring function outperforms the others with respect to the extraction. The Surflex_Score provided reliable poses that were ranked best by D_Score and jain. The D_Score and ChemScore provided reliable poses that were ranked best by Ludi_1.