Conclusion: Our study demonstrates the delay of the parotid gland structural maturation in pregnancies complicated with IUGR. Impaired growth and secretory gland's dysfunctions may cause pathological changes in oral ecosystem of a child. Objective: Dermal fillers are injectable products commonly used in aesthetic medicine. This type of treatment, which often replaces traditional surgical procedures provides satisfactory cosmetic results. It is known, however, that there is a risk of undesired effects at the site of injection of the product or even at a distance. Literature reports numerous cases of orofacial injuries caused by dermal fillers. The aim of this study is to evaluate two of the most widely used facial dermal fillers for aesthetic purposes in an effort to identify adverse reactions they may produce. Method: Two of the most commonly used materials for aesthetic purposes by dermatologists and plastic surgeons, polymethylmetacrylate and hialuronic Acid were injected in rat tongues: 10 % polymethylmethacrylate (n = 16) and 20 mg/mL hyaluronic acid (n =18), compared to an inert solution for control (n=16). After 7, 60 and 90 days, local clinical and histological alterations were analyzed. Results: The following factors were verified: intensity of the inflammatory response (H&E), amount of newly formed blood vessels (IHC) and macrophages and collagen fibers density (picrosirius). Results showed that both filling materials triggered local inflammatory response to a greater or lesser degree. Objective: The aim of this study was to compare clodronate and zoledronic acid regarding their influence on the repair of surgical wounds in maxillae (soft tissue wound and tooth extraction) and their relation to osteonecrosis.