Objective: The tumor stage and grade of bladder tumors are the major elements to define the prognosis. However, it is sometimes difficult to identify an infiltration of chorion or detrusor muscle. Moreover, the evaluation of tumor grade is subjective and not reproducible. Method: Our objective is to study the prognostic value of the expression of proliferating cell nuclear antigen (PCNA), Ki67 antigen, the tumor suppressor gene p53, the protooncogene c-erb B2, the receptor for Epidermal Growth Factor (EGF-R), the apoptosis suppressor gene bcl2, carcinoembryonic antigen (CEA) and Epithelial Membrane Antigen (EMA). Results: The study showed that the PCNA expression was significantly associated with the early recurrence (p=0.010) and the tumor stage (p=0.003). The Mib1 expression was correlated to the early recurrence (p=0.010), and tumor progression in stage and/or grade (p=0.007). The c-erbB2 expression showed significant association with the tumor grade (p=0.007). The prognostic value of other markers has not been proven. Conclusion: These findings may be useful providing better classification of bladder tumors thus the better management of patients. The c-erbB2 expression contributes to refine the tumor grading. PCNA and Mib1 can predict the early tumor recurrence; they could be relevant for the determination of endoscopic controls rhythms of patients. Objective: Primary urinary bladder neuroendocrine carcinoma (PUBNEC) is a rare tumor characterised by an aggressive behaviour and poor prognosis. Method: We report five cases of PUBNEC diagnosed in the departement pathology of Farhat Hached Hospital between 1990 and 2011. Results: Our population is composed by four mens and a woman. All patient are heavy smokers. The most common presenting symptom is hematuria and dysuria in all cases. One patient presented a complete urinary retention. A cystoscopic examination with transurethral resection was performed in all cases. The pathological examination with use of immunohistochemical markers of neuroendocrine differentiation were consistent with a large cell neuroendocrine carcinoma in four cases and a small cell neuroendocrine carcinoma in a case. A cystoprostatectomy was made in two cases followed by chemotherapy. Conclusion: The clinical presentation of PUBNEC is similar to other bladder cancers and is characterized by advanced stage at diagnosis and rapidly progressive disease. The diagnosis of poses several problems: a vesical metastasis has to be excluded and such lesions have to be differentiated from transitional cell carcinoma, lymphoma, paraganglioma and peripheral nerve neuroblastoma. There is no gold standard for the management of patients affected due to low disease frequency PS-22-052 IgG4-associated Inflammatory Pseudo-tumor (IPT) of the ureter: A case report A. Marando * , G. D´Ambrosio, F. Catanzaro, F. Sessa * University of Insubria, Dept. of Surgical, Varese, Italy