We will now discuss three of these genes in the context of current biological knowledge on melanoma drivers and metastatic progression. We provide many references for one of them, SPP1 (Secreted phosphoprotein 1 or Osteopontin). The discussion on this gene will be left for later, when we will discuss specifc oncosystems related to cell proliferation, chemotaxis and responses to external simulus. Figure 7 shows the expression of ADA (Adenosine deaminase, AA683578) as a function of TP63 (keratinocyte transcription factor KET, AA455929). All normal skin samples, as well as nevi and a couple of primary melanomas have relatively low values of ADA but they express TP63. There is a change of roles in metastatic and some primary melanomas, which have reduced TP63 expression but increased values of expression of ADA. As we will later see, these events correlate with other major transcriptional modifications which involve dozens of genes and that we have been able to map thanks to functional genomics bioinformatics tools. The role of SPP1 will be discussed in that context after some references to TP63, ADA, and PLK1 which follow.