Reduction of the contact intensity through quarantine and social distancing has proven to be one of the most effective containment measures, especially in the early stages of the pandemic [27, 30, 31, 41] . Figure 9 shows the sensitivity of the average total cost and average total deaths to the social distancing conformance ranging between 60% and 80%. We observed that for both impact measures, the DPO policy demonstrated a better performance with the difference ranging from $3B to $26B in the total cost and from 1,400 to 20,000 in the number of fatalities. The biggest difference in performance was achieved at the lower-to-medium levels of conformance (between 65% and 72%). As the conformance level approached 80%, the dominating impact of social distancing masked the effect of better utilization of vaccines and antivirals achieved by the DPO strategy.