The pathogenesis and progression of ALD are associated with free radical injury and oxidative stress, which could be partially attenuated by antioxidants and free radical scavengers. Lipid metabolism disorder and oxidative stress play an important role on the development and progression of ALD, and mitochondria compartment is presumed to be the main source and susceptible target of intracellular ROS. The hypothesis that quercetin could prevent ethanolinduced oxidative damage in hepatocytes has been investigated.