Classified within the family Picornaviridae, the genus Rhinovirus consists of 100 serotyped strains divided into two species, Human rhinovirus A (HRV A; n = 75) and Human rhinovirus B (HRV B; n = 25) [4] . Species classification was initially based on the susceptibility of strains to capsid binding antivirals [5, 6] and subsequently confirmed by phylogenetic studies [4, 7] . HRVs are also subdivided by receptor usage; major group HRVs use an intercellular adhesion molecule (ICAM-1; n = 88 strains), which interacts within a depression of the viral surface known as the canyon [8] . Minor group HRVs (n = 12) receive a molecule from the low density lipoprotein receptor family (LDLR) at protrusions along the 5-fold axis of the capsid surface [9] [10] [11] [12] . Recently, heparan sulphate was identified as a pH dependent, low efficiency receptor for HRV-54 [13] . A relationship between receptor usage and species identity is only evident among minor group HRVs; all are HRV As. Major group HRVs reside in both species. Studies have identified four neutralizing immunogenic sites on the surface of a major group HRV (HRV-14; NImIA, NImIB, NImII and NImIII) [14] and three sites on a minor group HRV (HRV-2; site A, B and C) [15] , with some overlap [16] . These sites consist of discontinuous amino acid sequence within VP1, VP2 and VP3.