Objective: In nephroblastoma cases association between decreased E-cadherin expression and higher stage of tumor (Safford SD, 2005) and lower expression in metastatic tumors (Alami J, 2003) was described. Some authors considered that E cadherin is not likely to play tumor suppressor role in nephroblastoma ( Shulz S, 2000) . Purpose of this study was to compare the expression of E-cadherin in metastatic and primary tumor cases in Latvia. Method: 26 cases of primary tumors, 8 metastases and 1 case of relapse were analyzed immunohistochemically using visualization system EnVision. The number of E-cadherin positive structures per field was assessed (magnification× 100). Comparison between primary tumors and metastatic/ relapse tumors groups was made using Mann-Whitney test. Results: In primary tumor group the number of positive structures in the field ranged from 0 to 86, average 27.19, SD 24.13. In the metastatic tumor group, the number of positive structures varied from 0 to 40, average 9.89, SD 14.87. Comparison of expression observed in both primary and metastatic tumors groups showed the decreased E-cadherin expression in metastatic tumor group (Z= −2.33, p=0.046). Conclusion: Expression of E-cadherin is lower in metastatic tumor group that may suggest about negative correlation between it and higher tumor grade.