---
license: cc-by-nc-4.0
tags:
- biology
- protein
- antibody
- VHH
---

## AVIDa-hIL6

AVIDa-hIL6 is an antigen-variable domain of heavy chain of heavy chain antibody (VHH) interaction dataset produced from an alpaca immunized with the human interleukin-6 (IL-6) protein.
AVIDa-hIL6 includes binary labels indicating the binding or non-binding of diverse VHH sequences to wild type and 30 mutants of the IL-6 protein.
Further details on AVIDa-hIL6 are described in our paper "[AVIDa-hIL6: A Large-Scale VHH Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions
](https://arxiv.org/abs/2306.03329).”

## Columns

**AVIDa-hIL6.csv**

| Column          | Description                                                                       |
| --------------- | --------------------------------------------------------------------------------- |
| VHH_sequence    | Amino acid sequence of VHH                                                        |
| Ag_label        | Antigen Type                                                                      |
| label           | Binary label represented by 1 for the binding pair and 0 for the non-binding pair |
| subject_species | Species of the subject from which VHH was collected                               |
| subject_name    | Name of the subject from which VHH was collected                                  |
| subject_sex     | Sex of the subject from which VHH was collected                                   |

**antigen_sequences.csv**

| Column      | Description                    |
| ----------- | ------------------------------ |
| Ag_label    | Antigen Type                   |
| Ag_sequence | Amino acid sequence of antigen |

## Links

- Project Page: https://www.cognano.co.jp/datasets/avida-hil6
- Code: https://github.com/cognano/AVIDa-hIL6
- Paper: https://arxiv.org/abs/2306.03329

## Citation

If you use AVIDa-hIL6 in your research, please cite the following paper.

```bibtex
@inproceedings{tsuruta2023avida,
  title={{AVID}a-h{IL}6: A Large-Scale {VHH} Dataset Produced from an Immunized Alpaca for Predicting Antigen-Antibody Interactions},
  author={Hirofumi Tsuruta and Hiroyuki Yamazaki and Ryota Maeda and Ryotaro Tamura and Jennifer N. Wei and Zelda Mariet and Poomarin Phloyphisut and Hidetoshi Shimokawa and Joseph R. Ledsam and Lucy Colwell and Akihiro Imura},
  booktitle={Advances in Neural Information Processing Systems 36},
  year={2023},
}
```