List of cocaine analogues
para-substituted benzoylmethylecgonines
The MAT binding pocket analogous to the lipophilic place on cocaine-like compounds, inclusive of the benzene ring, is approximate to 9 Å in length.

List of cocaine analogues

Section Title: para-substituted benzoylmethylecgonines
Table Section Text: The MAT binding pocket analogous to the lipophilic place on cocaine-like compounds, inclusive of the benzene ring, is approximate to 9 Å in length.

Structure	S. Singh's alphanumeric assignation (name)	4′=R	DAT [3H]WIN 35428	5-HTT [3H]Paroxetine	NET [3H]Nisoxetine	Selectivity 5-HTT/DAT	Selectivity NET/DAT

(cocaine)	H	249 ± 37	615 ± 120	2500 ± 70	2.5	10.0

non-benzoyloxy analogue comparative ligands non-tropane analogue comparative ligands	11b (WIN 35428) (nisoxetine) (fluoxetine)	F — —	24 ± 4 775 ± 20 5200 ± 1270	690 ± 14 762 ± 90 15 ± 3	258 ± 40 135 ± 21 963 ± 158	28.7 1.0 0.003	10.7 0.2 0.2

Satendra Singh Rev

183a	I	2522 ± 4	1052 ± 23	18458 ± 1073	0.4	7.3

183b	Ph	486 ± 63

183c	OAc	144 ± 2

183d	OH	158 ± 8	3104 ± 148	601 ± 11	19.6	3.8

(4′-Fluorococaine)	F

(para-Isothiocyanatobenzoylecgonine methyl ester) (p-Isococ)	NCS

Sentence(s)

The structure of cocaine is WIN 35428, with an addition of para substitution of methyl.

final_sentence: The structure of cocaine is WIN 35428, with an addition of para substitution of methyl.