Synthetic cannabinoids
Structural classifications

Synthetic cannabinoids

Section Title: Structural classifications
Table Section Text: None

Name	Year Identified by Forensics	Structural Classification	Structure	CB1 Binding Affinity (nM)	CB2 Binding Affinity (nM)	CB1 EC50 (nM)	CB2 EC50 (nM)

Δ9-THC	Classical Cannabinoid	-	41 ± 2	36 ± 10	250	1157

HU-210	2009	Classical Cannabinoid	-	0.061 ± 0.007	0.52 ± 0.04

(C8) CP 47,497	2008	Non-Classical Cannabinoid (Cyclohexylphenol)	-	2.20 ± 0.47

JWH-018	2008	Aminoalkylindole (Naphthoylindoles)	-	9.0 ± 5.0	2.94 ± 2.65	102	133

AM-2201 (Fluorinated JWH-018)	2011	Aminoalkylindole (Naphthoylindoles)	-	1.0	2.6	38	58

UR-144	2010	Tetramethylcyclopropylindoles	-	29 ± 0.9	4.5 ± 1.7	421	72

XLR-11 (Fluorinated UR-144)	2012	Tetramethylcyclopropylindoles	-	24 ± 4.6	2.1 ± 0.6	98	83

APICA	2012	Adamantoylindole	-	128	29

STS-135 (Fluorinated APICA)	Adamantoylindole	-	51	13

AB-PINACA	2012	Indazole carboxamide	-	1.2	2.5

PB-22	2013	Quinolinyl ester	-	5.1	37

5F-PB-22 (Fluorinated PB-22)	Quinolinyl ester	-	0.468	0.633	2.8	11

Sentence(s)

C8 of CP-47,497 is a synthetic cannabinoid.

final_sentence: C8 of CP-47,497 is a synthetic cannabinoid.