Antiandrogen
Androgen receptor antagonists
AR antagonists act by directly binding to and competitively displacing androgens like testosterone and DHT from the AR, thereby preventing them from activating the receptor and mediating their biological effects.

Antiandrogen

Section Title: Androgen receptor antagonists
Table Section Text: AR antagonists act by directly binding to and competitively displacing androgens like testosterone and DHT from the AR, thereby preventing them from activating the receptor and mediating their biological effects.

Compound	AR	ER	PR	GR	MR

Metribolone	290	< 0.1	190	4	38

Dihydrotestosterone	180	?	?	?	?

Testosterone	100	?	?	?	?

Cyproterone acetate	10	?	?	?	?

Bicalutamide	1.8	?	?	?	?

Nilutamide	0.8	?	?	?	?

Hydroxyflutamide	0.8	?	?	?	?

RU-59063	300	<0.1	<0.1	<0.1	<0.1

RU-58841	150	?	?	?	?

RU-58642	46	<0.1	<0.1	<0.1	<0.1

RU-57073	163	<0.1	<0.1	<0.1	<0.1

RU-56187	92	<0.1	<0.1	<0.1	<0.1

Notes: Values are RBAs (%). Reference ligands (100%) were testosterone for the AR, estradiol for the ERα and ERβ, progesterone for the PR, dexamethasone for the GR, and aldosterone for the MR.

Sentence(s)

The Antiandrogen includes the AR antagonists cyproterone acetate, RU-58642, and RU-58841.

final_sentence: The Antiandrogen includes the AR antagonists cyproterone acetate, RU-58642, and RU-58841.