List of cocaine analogues
2β-substitutions (including transesterification metabolite substitution cocaethylene)

List of cocaine analogues

Section Title: 2β-substitutions (including transesterification metabolite substitution cocaethylene)
Table Section Text: None

Structure	S. Singh's alphanumeric assignation (name)	R	DAT [3H]WIN 35428	5-HTT [3H]Paroxetine	NET [3H]Nisoxetine	Selectivity 5-HTT/DAT	Selectivity NET/DAT

Satendra Singh Rev

(Cocaine)	Me	89 ± 4.8	1045 ± 89	3298 ± 293	11.7	37.0

196a (Cocaethylene)	Et	195 ± 45	5801 ± 493	10000 ± 751	29.7	51.3

196b	n-Pr	196 ± 46	4517 ± 430	6124 ± 262	23.3	31.2

196c	i-Pr	219 ± 48	25224 ± 1498	30384 ± 1685	115	139

196d	Ph	112 ± 31	33666 ± 3330	31024 ± 1909	300	277

196e	Bn	257 ± 14	302 ± 23	20794 ± 950	1.2	80.9

196f	β-phenethyl	181 ± 10	615 ± 52	19944 ± 1026	3.4	110

196g	γ-phenylpropyl	147 ± 19	374 ± 15	4893 ± 344	2.5	33.3

196h	cinnamyl	371 ± 15	368 ± 6.3	68931 ± 3476	1.0	186

196i	p-NO2-β-phenethyl	601 ± 28

196j	p-Cl-β-phenethyl	271 ± 12

196k	p-NH2-β-phenethyl	72 ± 7

196l	p-NCS-β-phenethyl	196 ± 14

196m	p-azido-β-phenethyl	227 ± 19

196n	(p-NHCOCH2Br)β-phenethyl	61 ± 6

196o	(p-NHCO(CH2)2CO2Et)β-phenethyl	86 ± 4

Satendra Singh Rev	197a	NH2	753 ± 41.3	13725 ± 1256	3981 ± 229	18.2	5.3

197b	NMe2	127 ± 6.36	143713 ± 8854	7329 ± 158	1131	57.7

197c	N(OMe)Me	60 ± 6.4	28162 ± 2565	3935 ± 266	469	65.6

197d	NHMe	2424 ± 118	44798 ± 2105	4213 ± 206	18.5	1.7

197e (Benzoylecgonine)	OH	195000

Satendra Singh Rev	197f	HOCH2-	561 ± 149

197g (Tropacocaine)	H	5180 ± 1160

Sentence(s)

197c had a 469 DAT, cocaine analogue.

final_sentence: 197c had a 469 DAT, cocaine analogue.