BRCA1
Germ line mutations and founder effect

BRCA1

Section Title: Germ line mutations and founder effect
Table Section Text: None

Population or subgroup	BRCA1 mutation(s)	Reference(s)

African-Americans	943ins10, M1775R

Afrikaners	E881X

Ashkenazi Jewish	185delAG, 188del11, 5382insC

Austrians	2795delA, C61G, 5382insC, Q1806stop

Belgians	2804delAA, IVS5+3A>G

Dutch	Exon 2 deletion, exon 13 deletion, 2804delAA

Finns	3745delT, IVS11-2A>G

French	3600del11, G1710X

French Canadians	C4446T

Germans	5382insC, 4184del4

Greeks	5382insC

Hungarians	300T>G, 5382insC, 185delAG

Italians	5083del19

Japanese	L63X, Q934X

Native North Americans	1510insG, 1506A>G

Northern Irish	2800delAA

Norwegians	816delGT, 1135insA, 1675delA, 3347delAG

Pakistanis	2080insA, 3889delAG, 4184del4, 4284delAG, IVS14-1A>G

Polish	300T>G, 5382insC, C61G, 4153delA

Russians	5382insC, 4153delA

Scottish	2800delAA

Spanish	R71G

Swedish	Q563X, 3171ins5, 1201del11, 2594delC

Sentence(s)

Three mutations in BRCA1: 185delAG, 188del11 and 5382insC were reported for Ashkenazi Jewish.

final_sentence: Three mutations in BRCA1: 185delAG, 188del11 and 5382insC were reported for Ashkenazi Jewish.