Testosterone (medication)
Pharmacokinetics
Testosterone is not active orally except in extremely high dosages due to poor absorption and extensive first-pass metabolism. In addition, steroidal androgens including testosterone are hepatotoxic and there is a potential for liver injury with high dosages of oral testosterone due to the production of supraphysiological local concentrations of drug in the liver.

Testosterone (medication)

Section Title: Pharmacokinetics
Table Section Text: Testosterone is not active orally except in extremely high dosages due to poor absorption and extensive first-pass metabolism. In addition, steroidal androgens including testosterone are hepatotoxic and there is a potential for liver injury with high dosages of oral testosterone due to the production of supraphysiological local concentrations of drug in the liver.

Testosterone ester	Form	Route of administration	Elimination half-life	Mean residence time

Testosterone undecanoate	Oil-filled capsules	Oral	1.6 hours	3.7 hours

Testosterone propionate	Oil solution	Intramuscular injection	0.8 days	1.5 days

Testosterone enanthate	Castor oil solution	Intramuscular injection	4.5 days	8.5 days

Testosterone undecanoate	Tea seed oil solution	Intramuscular injection	20.9 days	34.9 days

Testosterone undecanoate	Castor oil solution	Intramuscular injection	33.9 days	36.0 days

Testosterone buciclatea	Aqueous suspension	Intramuscular injection	29.5 days	60.0 days

Notes: Testosterone cypionate has very similar pharmacokinetics to TE. Footnotes: a = Never marketed. Sources: See template.

Sentence(s)

Administered in the form of oil solutions, the half-lives are 0.8 days for testosterone propionate, 4.5 days for testosterone enanthate, 20.9 days (in tea seed oil) and 33.9 days (in caster oil) for testosterone undecanoate, and 29.5 days for testosterone buciclate.

final_sentence: Administered in the form of oil solutions, the half-lives are 0.8 days for testosterone propionate, 4.5 days for testosterone enanthate, 20.9 days (in tea seed oil) and 33.9 days (in caster oil) for testosterone undecanoate, and 29.5 days for testosterone buciclate.