List of Spider-Man enemies
The Amazing Spider-Man debuts
Most of the supervillains of Spider-Man would be introduced in The Amazing Spider-Man comic book starting with the Chameleon. The early villains would be introduced in the 1960s in the Silver Age of Comic Books, and created by Stan Lee and Steve Ditko.

List of Spider-Man enemies

Section Title: The Amazing Spider-Man debuts
Table Section Text: Most of the supervillains of Spider-Man would be introduced in The Amazing Spider-Man comic book starting with the Chameleon. The early villains would be introduced in the 1960s in the Silver Age of Comic Books, and created by Stan Lee and Steve Ditko.

Supervillain name	Notable alter ego	First appearance issue #	Creator	Descriptions

Chameleon	Dmitri Anatoly Nikolayevich Smerdyakov	#1 (March 1963)	Stan Lee Steve Ditko	Master of disguise. Can make himself look like anybody.

Vulture	Adrian Toomes Blackie Drago	#2 (May 1963)	Stan Lee Steve Ditko	An inventor that created mechanical wings that he harnessed to himself to let him fly and have superhuman strength.

Tinkerer	Phineas Mason	#2 (May 1963)	Stan Lee Steve Ditko	Gifted in engineering and creating gadgets from just about anything.

Doctor Octopus	Doctor Otto Gunther Octavius	#3 (July 1963)	Stan Lee Steve Ditko	Originally a scientist whose invention of metallic limbs had become fused to his body by an accident which caused his insanity.

Sandman	William Baker / Flint Marko	#4 (September 1963)	Stan Lee Steve Ditko	After bathed in a nuclear reaction. His body is formed with sand which is depicted that he can manipulate in many ways such as shapeshifting and increasing his density and strength to lift up to 85 tons along with increasing height, turning his hands into weapons such as hammer or a mace along with being able form a near-impenetrable wall of sand or create a dust storm.

Lizard	Dr. Curt Connors	#6 (November 1963)	Stan Lee Steve Ditko	Dr. Curt Connors tested himself an experimental serum from reptile DNA which created him as a giant humanoid Lizard.

Living Brain	Living Brain	#8 (January 1964)	Stan Lee Steve Ditko	A living robot that is designed to solve any problem.

Electro	Maxwell Dillon	#9 (February 1964)	Stan Lee Steve Ditko	As a lineman for an electric company, he was repairing a power line and holding a wire when lightning struck and mutated his nervous system making him a living electrical capacitor.

Big Man	Frederick Foswell Janice Foswell	#10 (March 1964)	Stan Lee Steve Ditko	A notorious crime lord of New York City.

Mysterio	Quentin Beck	#13 (June 1964)	Stan Lee Steve Ditko	Uses special effects that makes him a master of illusion. Also knows hypnosis.

Green Goblin	Norman Osborn Harry Osborn	#14 (July 1964)	Stan Lee Steve Ditko	The first Green Goblin is Norman Osborn, the CEO of Oscorp. He has Powers that derive from a "Goblin formula" that increase agility, endurance strength and reflexes to superhuman levels.

Kraven the Hunter	Sergei Kravinoff Alyosha Kravinoff (son) Ana Kravinoff (daughter)	#15 (August 1964)	Stan Lee Steve Ditko	Depicted as the world's greatest big-game hunter, Kraven the Hunter is the stepbrother of Chameleon. Prefers using his bare hands instead of guns.

Scorpion	Mac Gargan	#20 (January 1965)	Stan Lee Steve Ditko	A former private investigator. Endured a test that made him more powerful than Spider-Man but also insane.

Spencer Smythe / Spider-Slayers	Spencer Smythe Spider-Slayers: Multiple names	#25 (June 1965)	Stan Lee Steve Ditko	A robotic expert who created hte Spider-Slayers.

Crime Master	Various	#26 (July 1965)	Stan Lee Steve Ditko	A professional criminal who was the alias of different people.

Molten Man	Mark Raxton	#28 (September 1965)	Stan Lee Steve Ditko	A scientist who was covered in a liquid metallic alloy that not only gives him super-strength, but also enabled him to generate heat and radiation.

Looter	Norton G. Fester	#36 (May 1966)	Stan Lee Steve Ditko	A poor scientist who gains superpowers from meteor gas.

Robot Master / Gaunt	Mendel Stromm	#37 (June 1966)	Stan Lee Steve Ditko	A former college teacher and partner of Norman Osborn that became a cyborg after being betrayed by Osborn.

Rhino	Aleksei Mikhailovich Sytsevich	#41 (October 1966)	Stan Lee John Romita Sr.	Although classified as a fictional villain famous for being dimwitted. He has superhuman strength with a rhinoceros modeled armor when undergoing a chemical and radiation treatment which would transform him as being a collective of professional spies.

Shocker	Herman Schultz	#46 (March 1967)	Stan Lee John Romita Sr.	Wears a battle suit that contains vibro-shock gauntlets.

Kingpin	Wilson Fisk	#50(July 1967) ("Spider-Man No More!")	Stan Lee John Romita Sr.	Depicted as crime lord of New York City. Manipulate henchman to do his bidding.

The Finisher	Karl Fiers	Annual #5 (November 1968)	Stan Lee Larry Lieber

Man Mountain Marko	Michael Marko	#73 (June 1969)	Stan Lee John Romita Sr.	A mob lieutenant with super-strength

Silvermane	Silvio Manfredi	#73 (June 1969)	Stan Lee John Buscema	An aging crime boss.

Kangaroo	Frank Oliver Brian Hibbs	#81 (February 1970)	Stan Lee John Buscema Jim Mooney John Romita, Sr.	A name given to two kangaroo-themed villains.

Schemer	Richard Fisk	#83 (April 1970)	Stan Lee John Romita Sr.	The son of Kingpin.

Morbius	Michael Morbius	#101 (October 1971)	Roy Thomas Gil Kane	Has the power of a vampire along with their weaknesses.

Gog	N/A	#103 (December 1971)	Roy Thomas Gil Kane

Gibbon	Martin Blank	#110 (July 1972)	Stan Lee John Romita Sr.	A lesser criminal with gibbon-like abilities.

Hammerhead	Joseph (full name unknown)	#113 (October 1972)	Gerry Conway John Romita Sr.	An amnesica gangster whose skull was replaced with an unbendable steel alloy.

Man-Wolf	John Jameson	#124 (September 1973).	Gerry Conway	When exposed to the Godstone, John Jameson transforms into the werewolf-like creature Man-Wolf.

Jackal	Miles Warren	#129 (February 1974)	Gerry Conway Ross Andru	Brilliant professor with the knowledge of cloning and using it to torment Spider-Man emotionally.

Tarantula	Various	#134 (July 1974)	Gerry Conway Ross Andru	A name given to different tarantula-themed villains.

Mindworm	William Turner	#138 (November 1974)	Gerry Conway Ross Andru	A superhuman with telepathic powers.

Grizzly	Maxwell Markham	#139 (December 1974)	Gerry Conway Ross Andru	An ex-professional wrestler that wears a grizzly bear-themed outfit.

Human Fly	Richard Deacon	Annual #10 (1976)	Len Wein Bill Mantlo Gil Kane	A criminal that was imprinted with the genetic code of a housefly.

Will o' the Wisp	Jackson Arvad	#167 (April 1977)	Len Wein Ross Andru	A former Roxxon employee who can manipulate his molecules.

Big Wheel	Jackson Wheele	#182 (July 1978)	Marv Wolfman Ross Andru Mike Esposito	A criminal that rides the Big Wheel vehicle.

Black Cat	Felicia Hardy	#194 (July 1979)	Marv Wolfman Keith Pollard	Expert burglary skills taught by her father along with carrying a grappling hook for swinging on rooftops. Had bad luck powers off and on.

Calypso	Calypso Ezili	#209 (October 1980)	Dennis O'Neil Alan Weiss	A voodoo accomplice of Kraven the Hunter.

Hydro-Man	Morris Bench	#212 (January 10, 1981)	Denny O'Neil John Romita Jr.	A former crewman who gained aquakinetic abilities following an accident during Spider-Man's fight with Namor.

Hobgoblin	Roderick Kingsley Jason Macendale Phil Urich	#238 (March 1983)	Roger Stern John Romita Sr.	Powers similar to Green Goblin after discovering Norman's lair. Perfecting Green Goblin's strength portion, goblin glider and pumpkin bombs without the insanity that Norman had.

Rose	Richard Fisk	#253 (June 1984)	Tom DeFalco	The alias of a gentleman-like crime lord with the alias used by different people including Kingpin's son Richard Fisk.

Alistair Smythe	Alistair Smythe	Annual #19 (November 1985)	Louise Simonson Mary Wilshire	The son of Spencer Smythe.

Slyde	Jalome Beacher	#272 (January 1986)	Tom DeFalco Sal Buscema	A chemist whose suit allow him to move at nearly 30 miles per hour (48 km/h). He is almost impossible to grasp and he is incredibly maneuverable

Venom	Eddie Brock Mac Gargan	#300	Todd McFarlane	The symbiote that once merged with Spider-Man as a suit mimics and enhances the abilities of Spider-Man once bonded with Eddie.

Styx and Stone	Jacob Eishorn and Gerald Stone	#309 (November 1988)	David Michelinie Todd McFarlane	A mad scientist and homeless man duo who fought Spider-Man. Styx has a disintegrating touch.

Carnage	Cletus Kasady	#361 (April 1992)	David Michelinie Erik Larsen Mark Bagley	Being an offspring of Venom. Carnage is an even stronger and more powerful character than Venom with his symbiotic powers.

Black Tarantula	Carlos LaMuerto	#419 (January 1997)	Tom DeFalco Steve Skroce	A tarantula-themed martial artist.

Morlun	N/	vol. 2 #30 (June 2001)	J. Michael Straczynski John Romita Jr.	A member of the Inheritors who can drain the life force out of totems.

Shathra	???	vol. 2 #46 (December 2006)	J. Michael Straczynski John Romita Jr. Scott Hanna	An insectoid creature from the Astral Plane.

Grey Goblin	Gabriel Stacy Lily Hollister (Menace)	#509 (August 2004) #550 (April 2008) (Menace)	J. Michael Straczynski Mike Deodato	A gray-resembling Green Goblin whose alias was used by different people.

Mister Negative	Martin Li	#546 (January 2008) (full appearance)	Dan Slott Phil Jimenez	The leader of the Inner Demons who is able to switch between reversed and regular appearance

Overdrive	???	Swing Shift (May 2007)	Dan Slott Phil Jimenez	A supervillain who can convert any vehicle into a high-powered one.

Screwball	???	#559 (May 2008)	Dan Slott Marcos Martin	The world's first "live streaming super-villain"

Massacre	Marcus Lyman	#655 (April 2011)	Dan Slott Marcos Martín	A brain-damaged criminal who lacks emotions.

Panda-Mania	???	Vol. 3 #1	Dan Slott Humberto Ramos	A giant panda-themed supervillain.

Sentence(s)

Adrian Toomes is the second villain Spider-Man encountered, after Chameleon.

final_sentence: Adrian Toomes is the second villain Spider-Man encountered, after Chameleon.