傅嫈惠

傅嫈惠（）是臺灣臺中豐原出身的美國華裔生物學家和人類遺傳學家，國立中興大學食品科學、俄亥俄州立大學畢業，目前是加州大學舊金山分校的神經學教授，美國國家科學院院士。

**生平**
1980年取得國立中興大學食品科學學位，1986年取得俄亥俄州立大學生物化學以及細胞生物學學位。之後，在俄亥俄州立大學和貝勒醫學院從事了博士後研究，主要研究內容為人類基因組。她在業界工作過四年後，返回學術界擔任猶他大學研究助理教授。2002年，在加州大學舊金山分校與合作者Louis Ptacek共同組建了實驗室。
2018年，當選為美國國家科學院院士與中華民國中央研究院生命科學組院士。

**部分出版物**
# Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptáček LJ, Fu Y-H.  An hPer2 phosphorylation site mutation in familial advanced sleep-phase syndrome. Science. 2001;291:1040-3.
# Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptáček LJ, Fu Y-H.  Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome. Nature. 2005;434:640-4.
# Padiath QS, Saigoh K, Schiffman R, Asahara H, Koeppen A, Hogan K, Ptáček LJ, Fu Y-H.  Lamin B1 duplications cause autosomal dominant leukodystrophy. Nat Genet. 2006 Oct ; 38(10)1114-23. Epub 2006 Sep 3.
# He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder J, Nishino S, and Fu Y-H.  Transcriptional suppressor DEC2 is a Regulator for Human Sleep Homeostasis. Science. 2009 325:866.
# Fu, YH and Marzluf, GA.  cys-3, the positive-acting sulfur regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein. J Biol Chem, 1990, 265, 11942-11947.
# Fu, Y.H., Kuhl, D.P., Pizzuti, et al.   Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell, 1991, 67, 1047-1058.    
# Fu, Y.H., Pizzuti, A., Fenwick, R.G., Jr., et al.   An unstable triplet repeat in a gene related to myotonic muscular dystrophy. Science, 1992, 255, 1256-1258.
# Yu, C.E., Oshima, J., Fu, Y.H., et al.   Positional cloning of the Werner's syndrome gene date=20200513102222 . Science, 1996, 272, 258-262.
# Levy‑Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu C, Jondro PD, Schmidt SD, Wang K, Crowley AC, Fu Y-H, Guenette SY, Galas D, Nemens E, Wejsman EM, Bird TD, Schellenberg GD, Tanzi RE.  Candidate gene for the chromosome 1 familial Alzheimer's disease locus. date=20190707031020  Science, 1995 269, 973-977.
# Xu Y, Toh KL, Jones CR, Shin JY, Fu Y-H*, Ptáček LJ.  Modeling of a human circadian mutation yields insights into clock regulation by PER2 date=20160516103846 . Cell. 2007 Jan 12:128(1):59-70.
# Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptáček LJ, Fu Y-H*.  Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock.Cell Metab. 2013 Feb 5;17(2):291-302.
# Brennan KC, Bates EA, Shapiro RE, Zyuzin J, Hallows WC, Huang Y, Lee HY, Jones CR, Fu YH, Charles AC, Ptacek LJ.  Casein kinase iδ Mutations in Familial Migraine and Advanced Sleep Phase date=20170420055606 .Science Transitional Mag. 2013 May 1; 183(5):183ra56.
# He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder J, Nishino S, and Fu Y-H. Transcriptional suppressor DEC2 is a Regulator for Human Sleep Homeostasis. Science. 2009 325:866.
# Kaasik K, Kivimäe S, Allen JJ, Chalkley RJ, Huang Y, Baer K, Kissel H, Burlingame AL, Shokat KM, Ptácek LJ, Fu YH. Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 5; 17(2):291-302. 23395175; 3597447.

**參見**
 睡眠的神經科學

**參考文獻**

**外部鏈接**
  Official profile at University of California date=20201030050803 - Official lab profile in collaboration with Louis Ptacek's lab at  UCSF-  Fu's personal website date=20200604093751