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What I meant was that regardless of the time taken, if a given protein transports the same amount in either direction (say, 1 glucose) and the transport protein cannot change its cofiguration back without transporting in the reverse direction, how can concentration on either side ever change? Ex. I have 10 particles outside, 5 inside, and 1 protein, whenever 1 goes in, this changes to 9 outside, 6 inside, but can never get to 8 outside, 7 inside because the protein's substrate binding spot is now inside, which means it cannot bind a new particle from the outside without first transporting a molecule from the inside back out, turning it back to 10 out, 5 in. clawx "