The two old folks at the beginning of the movie are like grandparents to her, and are out of the movie until the very end, when they reappear in miniature form, climbing out of a paper sack, and ultimately chasing her until she flees to her bedroom and commits suicide.  At the start to the movie, it might be supposed they are guardian angel figures, accompanying her to Los Angeles, but now that she's there, she's on her own. 

 * She tells the taxicab driver to take her to 1612 Havenhurst - the very name itself being suggestive of the English words heaven hurts - a reference to purgatory that probably escapes European viewers of this movie.  Of course, the street address also contains a reference to the numeral sixteen - later given even more significance by the inclusion of the song "Sixteen Reasons Why" and the numeral 12 always having mystical significance in European tradition.