Response 

 Thanks for your feedback. We did agree that our lead paragraph contained too much information, and we cut out some information that we felt was too detailed for the lead. We tried to link corticostriatothalamocortical hap, but could not find any websites that simply described what it is. However, we did link the general category of neuronal networks. Also, we could not find any pictures that depicted a Holmes tremor or the changes that occur in the brain. Therefore, we just did our best to describe the Holmes tremor and changes in the brain.