Very well-rounded article; I was able to grasp a good understanding of your topic from your explanations. Here are a few suggestions that you might find helpful. First, I think it may improve ease of reading if an acronym used for the first time in each section is defined. For example, in the second sentence of the Mechanism section, ICP can be introduced as "intracranial pressure (ICP)" so the reader doesn't have to scroll back up to find out what ICP stands for. Second, I think the last two sentences of the Signs and Symptoms section regarding Mayer waves should be edited and possibly combined to correct the fragment issue as well as improve the flow of the sentences. For instance, you might write: "Mayer waves, which are waves in arterial blood pressure that can be seen in electrocardiograph ECG registers or blood pressure traces, are symptoms of blood pressure increase in response to falling blood flow." Third, in the Causes section, brain plateau waves are mentioned; it might be helpful if brain plateau waves and its significance in relation to ICP increase can be briefly explained. I really enjoyed reading about the actual history of the Cushing Reflex, great job!