A question: 
 One syringe. 
 No liquid. 
 Flat end to plunger and end of inside syringe 
 Pushed fully in. 
 Seal inlet end. 
 Put in a vacuum chamber (like the one in the recent youtube vacuum experiment) 

 Could you open the syringe in the vacuum? 
 i.e could you pull back that plunger easily? 

  
 Moonshine