== Promotional and uncritical == 

 This entry looks very promotional and uncritical, which is a concern because many critics complain that Shire is been promoting its drugs heavily and inappropriately to the public. Here's a recent article in the New York Times: 
 http://www.nytimes.com/2015/02/25/business/shire-maker-of-binge-eating-drug-vyvanse-first-marketed-the-disease.html? 
 Shire, Maker of Binge-Eating Drug Vyvanse, First Marketed the Disease 
 By KATIE THOMAS 
 FEB. 24, 2015 
 (Vyvanse (Shire) is an amphetamine prodrug, $1.5 billion/year sales, recently new approval for binge eating. FDA granted priority approval, without advisory committee hearings or recommendations, because there was no other drug to treat binge eating. Shire hired retired tennis player Monica Seles to make the talk show circuit to promote awareness of binge eating. Shire similarly promoted Adderall and Vyvanse for ADHD. Lawrence H. Diller, behavioral pediatrician, Walnut Creek, CA, and critic of ADHD treatment, quoted. Shire web site on binge eating disorder offers printable symptom checklist and opening lines to start conversation with doctor, tells patients “don’t give up” if a doctor initially resists. Critics say "appeared to coach patients about how to receive a diagnosis for a relatively uncommon condition, or shop for a new doctor if they were not successful.") 

 This entry also seems to be quoting selectively from the Cochrane reviews. Here's one that I got with a search for lisdexafetamine: 
 http://www.aafp.org/afp/2012/0901/p413.html 
 Amphetamines for Attention-Deficit/Hyperactivity Disorder in Adults 
 Am Fam Physician. 2012 Sep 1;86(5):413-415. 
 Authors' Conclusions: Amphetamines improved short-term ADHD symptom severity. Mixed amphetamine salts also increased retention in treatment. Amphetamines were associated with higher attrition due to adverse events. The short study length and the restrictive inclusion criteria limit the external validity of these findings. Furthermore, the possibility that the results of the included studies were biased was high, which could have led to an overestimation of amphetamine efficacy.