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Genetically Modified Organism (GMO) is one of the most important issues from around the world. GMOs are special organisms in which the genetic material has been altered for improvement productivity and product quality. GMOs have raised concerns over their own beneficial in that they are resistant to disease, help humans suffering from famine, produce greater yields, and improve the nutrition of foods. Having foods is very important to human life to maintain good health and to survive. It is not secret that GMO-ed foods have spread out rapidly to the whole world. If we could not stop the proliferation of GMO, we should know why it is harmful to our health and how we can prevent it. First of all, GMOs are harmful to our health. Second, transgenic crops lead to serious destruction of the environment and have contaminated organic crops. Third, major companies, which work closely with GMOs, intend to monopolize market-foods. Finally, to prevent GMO, it should be labeled and people should be recognized how dangerous GMO for us. First of all, in the fact that mankind doesn"t have tried to eat GMOs injected a gene from another species, GMOs will not be ensured food security unlike proven organic foods which has been eaten for human history. In despite of the dangerousness, the foods have still been on our table without verification. No one can guarantee that how GMOs" side effects will be long-term and continuous and proving safety is beyond the capabilities of current technology. Supporters of genetic engineering argue that the application of biotechnology to improve the nutritional contents of various foods will help people who suffer many deficiency diseases. Also, they claim that GM foods can yields medical benefit by injecting a particular genes or vaccine. However, GMOs are only a temporary measure, not the fundamental solution for nutritional improvement of foods and medical benefits. Their own disadvantages far outweigh their own advantages. A study by the American Academy of Environmental Medicine (AAME) advised precaution because GM foods have not been tested for human consumption and because there is significant evidence of probable harm (AAME, 2009). The harmful effects that have raised up to now are that GMOs can cause food allergy reactions, indirect and non-traceble effects on cancer rate, unknown effects on human health and malfunction immune system. Several studies bear testimony to the dangerousness. For instance, according to the study conducted by Dr. "rp"d Pusztai at the Rowett Research Institute in 1998, the result of his research showed feeding GM potatoes to rat led them to malfunction of immune systems (Arpad, 1998). The other research published in New Scientist at Purdue University, the research showed that releasing a transgenic fish to the wild could damage native population even to the point of extinction (Chris, 2000). Therefore, it is evident that GM foods are harmful to our health. Second, transgenic crops have destroyed our environment and organic farming industry impossible by contaminating organic foods. Advocates of GMO assert that transgenic crops possessed harmful insect resistance and herbicide resistance helps to reduce the environmental contamination. However, the resistance genes injected to the crops could easily spread to the ecological system. Consequently, the change has resulted in being caught in a vicious circle due to the birth of super weeds and super insect by spreading the genes to them. Also, the emergence of a mutation by biotechnology has altered the ecology and gives rises to destruction natural restoration. The U.S Environmental Protection Agency (EPA) regulates pesticides. They said that GMO crops often have posed serious risks to the ecology in 2000 because the crops which contained "plant incorporated pesticides" (Bt toxin) killed useful insects and produced the toxin by the plant as it grows. Also, the EPA evaluates risks to human health, non-target organisms, and the environment by pesticides. Even worse, it is impossible to abolish GM crops like it is impossible to dispose of nuclear waste from a nuclear generator. Restoration ecology plays an important role in organic farming. GM crops have a disastrous effect on organic farming, especially in light of the most important parts of organic crops is keeping its cleanness and lacking of pollution. However, seeds of GM plants are carried by wind and contaminate the natural plants. According to a research study conducted in Hokkaido, Japan, it cannot prevent GMO Cross-contamination to set up buffer zones between GMO farming and organic farming. GMO pollution caused by pollen drift is spreading in GM crops cultivation areas such as the USA and in Canada. GMO contamination will occur once GM crops are cultivated. Therefore, the co-existence between GMO farming and conventional farming or organic farming is very difficult (Keisuke, 2008). Another example is BBC News reported the result of a study conducted by the UK-based National Pollen Research in 1999. The result showed that airborne GM pollen can be carried hundreds of kilometers in 24 hours, and the pollen was found 4.5 km from a field of GM oilseed rape in Oxford shire. Genetic pollution will destroy organic farming industry which care and love pesticide-free, GMO-free vegetables for citizens. Third, GM crops are being forced on the whole world by biotechnology multi-nationals seeking monopolies for their products. After Green Revolution, agriculture in many countries reorganized their own farming industry to increase productivity and tried to change to be the mechanization of agriculture and depended gradually on the petrochemical industry. It is a true agricultural output has risen, but agriculture is subjugated to Multi-nationals rule forever. By having a lot of output, consumers and farmers get a profit, but companies such as Monsanto, Novartis and Aventis get a lot of profits. Their rules of food have been far more serious. In Monsanto case, the company developed herbicide Round up, Roundup Ready Soybeans which only work on Round up and have made unreasonable profits by them. So, when farmers buy their products, they should buy both of them. Moreover, Roundup Ready Soybeans use 2-5 times more herbicides than non-GM plants. This way, multi-naturals have encroached on the whole world food markets. When all food in the world becomes GM foods or their products, we could not imagine what will happen to human from a point of view of the food problem. People who advocate GM crops and some people affirm that it is an obvious fact to be guaranteed to solve the food problem because of improvement productivity. However, the fact is definitely not true. There is no relationship between the prevalence of hunger in a given country and its population (Lappe, 1998). The real reason of hunger and famine is the public are poverty, unequal division and limited foods in developing countries. The food problem is not about how yields increase, it is related to the fair distribution of food. Finally, to prevent GMO, it should be labeled and people should be recognized how dangerous GMO for us. Sharply and accuracy awareness is required to the people to recognized GM foods dangerousness to health, GM crops of damage to the natural environment, a hidden agenda in multi-naturals. In Western Europe and Japan, diffusion of GMOs has been less than 2% because environmental groups call GMOs to Frankenstein foods because of their own disadvantages and the general public avoids the foods. However, In USA, GMO rate is in serious condition. Most of major crops came from GMO, it is more than 50%. Also, All GM food must be labeled for protection nationals against potential risks of eating the foods. Labeling is consistent with the right to know for consumers. And it is the best way to give consumer a choice to buy GM foods. It is consistent with the right to choose for consumers. Then, the fact that is GM foods" disadvantages will be known to the people, they will not buy the foods. This strategy will prevent monopolism of major companies and proliferation GM crops. To do that, People should hold the right perception about GM crops and the companies, and GM foods should be labeled to be noticed by consumer.