Most people on antidepressants are being duped

Gusto ko ang iyong pangalan, kurokuro. Ito nababagay sa iyo.____the placebo effectThere is a very large placebo effect associated with drug intervention for depression (1).For mild and moderate depression, the placebo effect is not significantly different from the drug effect for most popular antidepressants (2). This means that although these patients do benefit significantly from taking antidepressants, they would benefit as much from taking a placebo. It is only for severely depressed patients that the drug effect exceeds the placebo effect. These patients do benefit from antidepressants. A recent US by Browse to Save" href="../../Most-people-on-antidepressants-are-being-duped/1/">survey of antidepressant use found that only one third of people taking antidepressants had severe depression (3). Therefore, two thirds (most) of the people taking antidepressants are benefitting from the medication no more than they would from a placebo.Finally, the placebo effect associated with antidepressants has been increasing in the decades since they were introduced into our society (4). As antidepressants become more popular, and people believe more and more in the drug company rhetoric, they have more faith in the effects of the drug and the placebo effect is enhanced. This has consequences for society in general, which I may discuss further in the next round.If people are benefitting from antidepressants, who cares if the effect is a placebo effect or a pharmacological one? A benefit is a benefit, right? Yes, which is no doubt why general practitioners keep on writing those prescriptions. (In fact, four of every five prescriptions for anti-depressants in the US come from non-psychiatrists (5)). However, antidepressants:a) are more expensive than a simple placebo (over $10 billion dollars spent on them each year in the US (6)); and b) have serious side-effects. Side effects include nausea, insomnia, anxiety, decreased sex drive, weight gain, fatigue, and headaches. There is also the risk of increased depression and suicidal behavior, especially in young people. Older people have an increased risk of fractures and bone loss. There are also serious withdrawal symptoms associated with antidepressants (7). Therefore, most people on antidepressants are being duped. They would be better off with a simple chalk pill or even some paracetamol. (1) Kirsch & Sapirstein, 'Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medication.' Prevention & Treatment, 1998 http://psychrights.org......(2) Kirsch et al., 'Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration' PLOS Medicine http://www.plosmedicine.org......Also see Fournier et al. 'Antidepressant Drug Effects and Depression Severity A Patient-Level Meta-analysis' JAMA 2010 http://jama.jamanetwork.com......(3) Pratt et al. 'Antidepressant Use in Persons Aged 12 and Over: United States, 2005–2008' NCHS Data Brief No.76, 2011 http://www.cdc.gov......(4) Walsh et al., 'Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing'JAMA. 2002;287(14):1840-1847. http://jama.jamanetwork.com......(5) B.Smith 'Inappropriate prescribing' Monitor on Psychology APA. 2012 http://www.apa.org......(6) T. Insel, 'Antidepressants: A complicated picture' National Institute of Mental Health, 2011 http://www.nimh.nih.gov......(7) http://www.helpguide.org......