The lateralization of brain function is the tendency for some neural functions or cognitive processes to be specialized to one side of the brain or the other. The median longitudinal fissure separates the human brain into two distinct cerebral hemispheres, connected by the corpus callosum. Although the macrostructure of the two hemispheres appears to be almost identical, different composition of neuronal networks allows for specialized function that is different in each hemisphere.

Instruction: What is the difference between the right and left side of the brain?
Response: The lateralization of brain function is the tendency for some neural functions or cognitive processes to be specialized to one side of the brain or the other. The median longitudinal fissure separates the human brain into two distinct cerebral hemispheres, connected by the corpus callosum. Although the macrostructure of the two hemispheres appears to be almost identical, different composition of neuronal networks allows for specialized function that is different in each hemisphere.

Lateralization of brain structures is based on general trends expressed in healthy patients; however, there are numerous counterexamples to each generalization. Each human's brain develops differently, leading to unique lateralization in individuals. This is different from specialization, as lateralization refers only to the function of one structure divided between two hemispheres. Specialization is much easier to observe as a trend, since it has a stronger anthropological history.

The best example of an established lateralization is that of Broca's and Wernicke's areas, where both are often found exclusively on the left hemisphere. Function lateralization, such as semantics, intonation, accentuation, and prosody, has since been called into question and largely been found to have a neuronal basis in both hemispheres. Another example is that each hemisphere in the brain tends to represent one side of the body. In the cerebellum, this is the same body side, but in the forebrain this is predominantly the contralateral side.

Language functions such as grammar, vocabulary and literal meaning are typically lateralized to the left hemisphere, especially in right-handed individuals. While language production is left-lateralized in up to 90% of right-handers, it is more bilateral, or even right-lateralized, in approximately 50% of left-handers.

Broca's area and Wernicke's area, associated with the production of speech and comprehension of speech, respectively, are located in the left cerebral hemisphere for about 95% of right-handers but about 70% of left-handers. 69  Individuals who speak multiple languages demonstrate separate speech areas for each language.

The processing of basic sensory information is lateralized by being divided into left and right sides of the body or the space around the body.

In vision, about half the neurons of the optic nerve from each eye cross to project to the opposite hemisphere, and about half do not cross to project to the hemisphere on the same side. This means that the left side of the visual field is processed largely by the visual cortex of the right hemisphere and vice versa for the right side of the visual field.

In hearing, about 90% of the neurons of the auditory nerve from one ear cross to project to the auditory cortex of the opposite hemisphere.

In the sense of touch, most of the neurons from the skin cross to project to the somatosensory cortex of the opposite hemisphere.

Because of this functional division of the left and right sides of the body and of the space that surrounds it, the processing of information in the sensory cortices is essentially identical. That is, the processing of visual and auditory stimuli, spatial manipulation, facial perception, and artistic ability are represented bilaterally. Numerical estimation, comparison and online calculation depend on bilateral parietal regions while exact calculation and fact retrieval are associated with left parietal regions, perhaps due to their ties to linguistic processing.

Rather than just being a series of places where different brain modules occur, there are running similarities in the kind of function seen in each side, for instance how right-side impairment of drawing ability making patients draw the parts of the subject matter with wholly incoherent relationships, or where the kind of left-side damage seen in language impairment not damaging the patient's ability to catch the significance of intonation in speech. This has led British psychiatrist Iain McGilchrist to view the two hemispheres as having different value systems, where the left hemisphere tends to reduce complex matters such as ethics to rules and measures, and the right hemisphere is disposed to the holistic and metaphorical.

Depression is linked with a hyperactive right hemisphere. The delusional misidentification syndromes, reduplicative paramnesia and Capgras delusion are also often the result of right hemisphere lesions.

Damage to either the right or left hemisphere, and its resulting deficits provide insight into the function of the damaged area. Left hemisphere damage has many effects on language production and perception. Damage or lesions to the right hemisphere can result in a lack of emotional prosody or intonation when speaking. Right hemisphere damage also has grave effects on understanding discourse. People with damage to the right hemisphere have a reduced ability to generate inferences, comprehend and produce main concepts, and a reduced ability to manage alternative meanings. Furthermore, people with right hemisphere damage often exhibit discourse that is abrupt and perfunctory or verbose and excessive. They can also have pragmatic deficits in situations of turn taking, topic maintenance and shared knowledge.

Lateral brain damage can also affect visual perceptual spatial resolution. People with left hemisphere damage may have impaired perception of high resolution, or detailed, aspects of an image. People with right hemisphere damage may have impaired perception of low resolution, or big picture, aspects of an image.

If a specific region of the brain, or even an entire hemisphere, is injured or destroyed, its functions can sometimes be assumed by a neighboring region in the same hemisphere or the corresponding region in the other hemisphere, depending upon the area damaged and the patient's age. When injury interferes with pathways from one area to another, alternative (indirect) connections may develop to communicate information with detached areas, despite the inefficiencies.

Broca's aphasia is a specific type of expressive aphasia and is so named due to the aphasia that results from damage or lesions to the Broca's area of the brain, that exists most commonly in the left inferior frontal hemisphere. Thus, the aphasia that develops from the lack of functioning of the Broca's area is an expressive and non-fluent aphasia. It is called 'non-fluent' due to the issues that arise because Broca's area is critical for language pronunciation and production. The area controls some motor aspects of speech production and articulation of thoughts to words and as such lesions to the area result in specific non-fluent aphasia.

Wernicke's aphasia is the result of damage to the area of the brain that is commonly in the left hemisphere above the Sylvian fissure. Damage to this area causes primarily a deficit in language comprehension. While the ability to speak fluently with normal melodic intonation is spared, the language produced by a person with Wernicke's aphasia is riddled with semantic errors and may sound nonsensical to the listener. Wernicke's aphasia is characterized by phonemic paraphasias, neologism or jargon. Another characteristic of a person with Wernicke's aphasia is that they are unconcerned by the mistakes that they are making.

Terence Hines states that the research on brain lateralization is valid as a research program, though commercial promoters have applied it to promote subjects and products far outside the implications of the research. For example, the implications of the research have no bearing on psychological interventions such as eye movement desensitization and reprocessing (EMDR) and neurolinguistic programming, brain-training equipment, or management training.

Some popularizations oversimplify the science about lateralization, by presenting the functional differences between hemispheres as being more absolute than is actually the case. Interestingly, research has shown quite opposite function of brain lateralisation, i.e. left hemisphere creatively and chaotically links between concepts and right hemisphere tends to adhere to specific date and time, although generally adhering to the pattern of left-brain as linguistic interpretation and right brain as spatio-temporal.

In the 19th century and to a lesser extent the 20th, it was thought that each side of the brain was associated with a specific gender: the left corresponding with masculinity and the right with femininity and each half could function independently. The right side of the brain was seen as the inferior and thought to be prominent in women, savages, children, criminals, and the insane. A prime example of this in fictional literature can be seen in Robert Louis Stevenson's Strange Case of Dr. Jekyll and Mr. Hyde.