What is the largest city on the Mississippi River?

Context: Memphis is the fifth-most populous city in the Southeast, the nation's 28th-largest overall, as well as the largest city bordering the Mississippi River and third largest Metropolitan statistical area behind Saint Louis, MO and the Twin Cities on the Mississippi River. The Memphis metropolitan area includes West Tennessee and the greater Mid-South region, which includes portions of neighboring Arkansas, Mississippi and the Missouri Bootheel. One of the more historic and culturally significant cities of the Southern United States, Memphis has a wide variety of landscapes and distinct neighborhoods.

Answer: Saint Louis, Missouri is the largest city on the Mississippi River. Twin Cities is the second largest city on the Mississippi River and Memphis is the third largest city on the Mississippi River.