[en] Introduction: Obesity and visceral fat excess are normally related to high blood pressure and increased plasmatic glucose and serum lipid levels. The growing prevalence of those cardiometabolic risk factors is promoting the development of drugs and dietary supplements, in order to control and treat them. Products containing Caralluma fimbriata have already been tested in some prior clinical trials and are proposed to help in weight loss and stabilization of physiological variables. Objectives: Evaluate the efficacy of a dietary supplement (OBEX®) on body composition and physiolo - gical status of women in climateric phase. Methods: The sample consisted of 44 women (25 pre - menopausal; 19 postmenopausal women) who resided in the county of Madrid, with a body mass index over 25 kg/m2 and ages between 35 and 62 years old. After signing an informed consent form, all participants were subjected to a treatment of 8g a day (OBEX®) (3g/day of caralluma fimbriata) during two months. At both the beginning and the end of the treatment, height, weight, waist and hip umbilical perimeters, thickness of subcutaneous folds and body composition by electrical impedance (TANITA®600) were measured. body mass index and waist-hip ratio were estimated and both blood cholesterol and glucose levels as well as blood pressure were assessed. Results: After two months of treatment, 52.78% of participants had lost weight resulting in an average weight loss of 1.86Kg. Premenopausal women had significantly decreased the thickness of their bicipital (3.3mm), subscapular (2.5mm) and suprailiac (3.1mm) skinfolds. Besides, postmenopausal women had reduced their bicipital (1.2mm), tricipital (2.3mm), subs - capular (2.0mm) and suprailiac (3.1mm) skinfolds and had increased their trunk muscle mass (0.5 Kg). In both groups the amount of women classified with abdominal obesity by means of waist-hip ratio decreased, in addition to a lowering in the prevalence of high blood pressure, hypercholesterolemia and hyperglycemia. Discussion: The weigth loss and muscle mass profit obtained using supplements containing Caralluma fimbriata, could help to decrease cardiovascular risk facts during menopause, at least employing the dose submitted in this work, greater than that used in previous studies, some of which also report a significant reduction in the analyzed anthropometric and physiological variables. Conclusions: The obtained results with the intake of the supplement OBEX® (containing 3g/day of Caralluma fimbriata) are promising for the treatment of central obesity and prevention of metabolic syndrome in climacteric women. However, it is necessary to carry out larger significance studies to verify its efficacy, employing a bigger sample and controlling variables such as diet and physical activity.

[es] Introducción: La obesidad y el exceso de grasa visceral habitualmente se asocian a la hipertensión y a altos niveles de glucosa plasmática y lípidos séricos. La creciente prevalencia de estos factores de riesgo cardiometabólico está generando el desarrollo de fármacos y suplementos alimentarios, destinados a su control y tratamiento. Los productos que contienen Caralluma fimbriata han sido probados en algunos ensayos clínicos previos y recomendados para bajar peso y estabilizar las variables fisiológicas. Objetivos: Valorar la eficacia de un suplemento nutricional (OBEX®) sobre la composición corporal y el estado fisiológico de mujeres en fase climatérica. Métodos: La muestra fue de 44 mujeres (25 pre menopáusicas; 19 post menopaúsicas) residentes en la comunidad de Madrid, con un índice de masa corporal superior a 25kg/m2 y edades comprendidas entre 35 y 62 años. Previo consentimiento informado se sometieron a un tratamiento de 8 g diarios de (OBEX®) (3 g/dia de Caralluma fimbriata) durante dos meses. Al comienzo y final de dicho periodo se les midió la talla, el peso, perímetros umbilical de la cintura y cadera, los pliegues grasos subcutáneos y la composición corporal mediante impedancia eléctrica (TANITA®600). Se estimó el índice de masa corporal y el índice cintura cadera y se evaluaron los niveles de colesterol, glucosa en sangre y presión arterial. Resultados: Tras dos meses de tratamiento, el 52,78 % de las participantes habían bajado peso con una pérdida media de 1,86 Kg. Las premenopaúsicas disminuyeron significativamente el grosor de los pliegues bicipital (3,3mm), subescapular (2,5mm) y suprailíaco (3,1mm). Las postmenopáusicas redujeron el bicipital (1,2mm), tricipital (2,3mm), subescapular (2mm) y suprailíaco (3,1mm) e incrementaron la masa muscular del tronco (0,5 kg p factores de riesgo cardiovascular durante la menopausia, al menos en la dosis suministrada en el presente trabajo, algo superior a la utilizada en estudios previos, parte de los cuales también reportan disminución significativa de las variables antropométricas y fisioló- gicas analizadas. Conclusiones: Los resultados obtenidos con una ingesta de suplemento de OBEX® (3g/día de Caralluma fimbriata) son prometedores para el tratamiento de la obesidad central y la prevención el síndrome metabó- lico en mujeres climatéricas. Sin embargo, para asegurar su eficacia es necesario llevar a cabo estudios de mayor alcance, con mayor efectivo muestral y control de variables como la dieta y la actividad física.