BSC-LT/ACAData huggingface dataset:
[en] Introduction. Drug abuse is one of the most significant problems of global health. Occupational Therapy (OT) is one of the social actors that promotes community participation, contributing to the occupational justice. However, OT theoretical perspectives used in research remain unpacked, which is essential for evidence-based practice. Objectives. Getting understanding of the role of Occupational Therapy in the existing scientific production about the problematic drug use. Methodology. A literature review was conducted using the methodology "scoping review". The following databases were searched: CINAHL, Cochrane Library Plus, Dialnet, EMBASE, ISI Web of Science, OTseeker, Scopus. The descriptive-analytic method and triangulation of researchers for the analysis of the data were used. Results. Three categories emerged: the "Contextualization", the "Research Priorities" - relationship between occupational performance and quality of life, assessment tools, description of OT interventions and its results - and the "Theoretical Research Perspectives" - a positivist view: neuroscience as support for the intervention, an empowering view: paving the way to inclusion, a systemic view: family and evaluations - from OT in drug addiction. Conclusions. Further research is needed on the problems of drug use from OT, using a critical paradigm based on the Science of Occupation.

[gl] Introdución. O consumo problemático de drogas representa un dos problemas de saúde máis significativos a nivel mundial. A Terapia Ocupacional (TO) é un dos actores sociais que promove a participación na comunidade, mediante a ocupación, contribuíndo á xustiza ocupacional. Non obstante, descoñécese qué perspectivas en TO estanse empregando en investigación, o cal é clave para unha práctica baseada na evidencia. Obxectivos. Coñecer cómo se entende o papel da Terapia Ocupacional na produción científica existente na problemática do consumo de drogas. Metodoloxía. Realizouse unha revisión bibliográfica empregando a metodoloxía "scoping review". Buscouse nas seguintes bases de datos: CINAHL, Cochrane Library Plus, Dialnet, EMBASE, ISI Web of Science, OTseeker, Scopus. Empregouse o método descriptivo-analítico e a triangulación de investigadores para realizar a análise dos datos. Resultados. Emerxeron tres categorías: a "Contextualización", as "Prioridades de investigación" - relación entre o desempeño ocupacional e a calidade de vida, instrumentos de avaliación, descrición das intervencións de TO e os seus resultados - e as "Miradas teóricas na investigación" - unha mirada positivista: a neurociencia como sustento da intervención, unha mirada empoderadora: construíndo o camiño cara a inclusión, unha mirada sistémica: familia e avaliacións - dende a TO en drogodependencias. Conclusións. É preciso continuar investigando acerca da problemática do consumo de drogas dende TO, empregando un paradigma crítico baseado na Ciencia da Ocupación.
[en] The dettached house in Collado Mediano, designed in 1964 by Alejandro de la Sota, was the only built project of his adventure with the precast concrete panels. Its uniqueness lay in the use of prestresed reinforced concree precast panels, which integrated structure and enclosure in the total envelope of the building, as well as other finishes and industrial materials outside the traditional domestic sphere at the time. The result, derived from the rationality of the construction, intended to be universal by the architect, and partly stressed by the local, was aligned with the desires of modernity in the search for a new architecture that at the beginning of the sixties, according to the historian of the architecture, Reyner Banham, it would not yet have materialized satisfactorily. The purpose of this thesis is the characterization of this architecture, differentiated in the professional career of the architect, for which the concept of tectonics of prefabrication is methodologically postulated as a specific category of tectonics, participated of the technological, the cultural and the inherent spatiality. From its tripartite consideration in its interrelation with the irreducible elements of the house, the domestic hearth, the stereotomic base and the tectonic envelope, the architectural essences found are distilled.

[gl] A vivenda unifamiliar de Collado Mediano, proxectada en 1964 por Alejandro de la Sota, foi o único proxecto construído a partir da súa aventura cos prefabricados de formigón. A súa singularidade residía no uso de paneis prefabricados pretensados de formigón armado, que integraban estrutura e cerramento na envolvente total do edificio, así como outros acabados e materiais industriais alleos ao ámbito doméstico tradicional da época. O resultado, derivado da racionalidade da construción, pretendida universal polo arquitecto, e en parte subliñado polo local, aliñase cos desexos de modernidade na procura dunha nova arquitectura que a principios dos anos sesenta, segundo o historiador da arquitectura Reyner Banham, aínda non se tería materializado satisfactoriamente. O obxecto desta tese é a caracterización desta arquitectura, diferenciada na carreira profesional do arquitecto, para a cal se postula metodoloxicamente o concepto de tectónica da prefabricación como categoría específica da tectónica, participada no tecnolóxico, no cultural e da espacialidade inherente. Da súa consideración tripartita na súa interrelación cos elementos irredutibles da casa, o fogar doméstico, a base estereotómica e a envoltura tectónica, destílanse as esencias arquitectónicas atopadas.
[en] Metformin is a drug widely used to treat Type 2 Diabetes, and has recently been described as a protective drug against cell aging. It is known that its main mechanism of action focuses on the activation of AMPK, one of the most important metabolic regulators that seems to trigger an activation of the autophagy mechanism to maintain cellular homeostasis. In fact, the autophagic mechanism is key to the survival of chondrocytes, the only cellular type of articular cartilage. In this study the analysis of autophagy-related gene expression levels in immortalized human chondrocytes stimulated with Metformin was performed to investigate which action targets the drug regulates. The results showed significant increases in the PTEN and GABARAPL1 genes, which seems to indicate that the drug acts by protecting the chondrocytes from inflammatory processes and contributes to the degradation of damaged mitochondria. However, the validation analyses with stimuli of Interleukin 1β in combination with Metformin did not show conclusive results based on the protective effect against inflammation, so it will be necessary to expand the number of experiments to achieve a more robust statistic as well as to analyze the levels of expression in arthritic chondrocytes that present a greater damage to corroborate the existence of a protective effect of Metformin on human cartilage and, therefore, offer a new treatment route for a disease with as much incidence as osteoarthritis.

[gl] A Metformina é un fármaco amplamente utilizado para tratar a Diabetes de Tipo 2, e recentemente describiuse coma un fármaco protector fronte ao envellecemento. Coñécese que o seu mecanismo de acción principal céntrase na activación de AMPK, un dos reguladores metabólicos máis importantes que parece desencadear unha activación do mecanismo de autofaxia para manter a homeostase celular. De feito, o mecanismo de autofaxia é clave para a supervivencia dos condrocitos, único tipo celular do cartílago articular. Neste estudo levouse a cabo o análise dos niveis de expresión dos xenes relacionados coa autofaxia en condrocitos humanos inmortalizados estimulados con Metformina para investigar que dianas de acción regula o medicamento. Os resultados amosaron incrementos significativos nos xenes PTEN e GABARAPL1, o que parece indicar que o fármaco actúa protexendo os condrocitos dos procesos inflamatorios e contribúe á degradación das mitocondrias danadas. Sen embargo, os análises de validación con estímulos de Interleucina 1β en combinación coa Metformina non amosaron resultados concluíntes en base ao efecto protector fronte á inflamación, de modo que será necesario ampliar o número de experimentos para conseguir unha estatística máis robusta así como analizar os niveis de expresión en condrocitos artrósicos que presenten un maior dano para corroborar a existencia dun efecto protector da Metformina sobre o cartílago humano e, polo tanto, ofrecer unha nova vía de tratamento para unha enfermidade con tanta incidencia como a artrose.
[en] Ovarian cancer is one of the most lethal gynecological malignancies worldwide. Since there are no methods for early detection, most patients are diagnosed in advanced stages (when metastases already exist), and current treatments are not effective. There is therefore an urgent need to investigate the underlying causes of the disease, discover early biomarkers and develop new drugs. Exosomes are a type of extracellular vesicles characterized by having a very diverse molecular content that can be transferred to adjacent or distant cells, playing a key role in the regulation of many physiological or pathological processes. In different types of cancer, including ovarian cancer, it has been observed that cancer cells release more exosomes than healthy cells and that they transport oncogenic molecules that participate in tumor progression. Furthermore, high concentrations of exosomes are found in various body fluids, thus they could be useful in liquid biopsy. On the other hand, the HMGB1 protein is a focus of attention in ovarian cancer research, it is overexpressed in ovarian tumor cells and contributes to a wide variety of hallmarks of cancer. In this context, the present work focuses on analyzing the influence of HMGB1 on the protein content of exosomes derived from ovarian cancer cells.

[gl] O cancro de ovario é unha das neoplasias malignas xinecolóxicas máis letais a nivel mundial. Debido a que non se dispón de métodos para a súa detección precoz, a maioría das pacientes son diagnosticadas en estadíos avanzados (cando xa existe metástases), e os tratamentos actuais non son eficaces. Existe, por tanto, a necesidade urxente de investigar as causas subxacentes á enfermidade, descubrir biomarcadores temperáns e desenvolver novos fármacos. Os exosomas son un tipo de vesículas extracelulares caracterizadas por presentar un contido molecular moi diverso que poden transferir a células adxacentes ou distantes, desempeñando un papel crave na regulación de multitude de procesos fisiolóxicos ou patolóxicos. En distintos tipos de cancro, entre os que se inclúe o de ovario, viuse que as células cancerosas liberan máis exosomas que as sas e que transportan moléculas oncoxénicas que participan na progresión tumoral. Ademais, atópanse altas concentracións de exosomas en varios fluídos corporais, polo que poderían ser útiles en biopsia líquida. Por outra banda, a proteína HMGB1 é foco de atención na investigación do cancro de ovario, atópase sobreexpresada en células tumorales ováricas e contribúe a unha gran variedade das características distintivas do cancro. Baixo este contexto, o presente traballo céntrase en analizar a influencia de HMGB1 no contido proteico de exosomas derivados de células de cancro de ovario.
[en] This paper examines the characteristics of electronic communication, a new means of interaction furthered by the advance of computer engineering and the Information and Communication Technologies, which enables people to exchange information in a synchronous or asynchronous mode, regardless of their physical location. In particular, we will focus our attention on the discursive properties of these new systems, which share traits with writing and speaking, but also have idiosyncratic elements (communication in absentia, simultaneous virtual presence, textual persistence etc.) as a result of the characteristics of the medium that contains them. These data allow us to affirm that we are facing a new mode of communication, independent of the oral and written mode and specific from Virtual Space.

[gl] Neste traballo analízanse as características da comunicación electrónica, un novo medio de interacción favorecido polo avanzo da Enxeñaría Informática e das Tecnoloxías da Información e da Comunicación que permite ás persoas intercambiaren información de modo sincrónico ou asincrónico con independencia da súa localización física. En concreto, focaremos a nosa atención nas propiedades discursivas destes novos sistemas, que partillan trazos coa escrita e coa oralidade, mais tamén presentan elementos idiosincráticos (comunicación in absentia, copresenza virtual, permanencia textual etc.), resultado das características do medio que os alberga. Estes datos permiten afirmarmos que estamos perante unha nova modalidade comunicativa, independente a respecto da oralidade e da escrita e específica do medio dixital.
[en] Objective: The aim of this study is to know the current evidence about physical therapy interventions in the treatment of vaginismus and to compare their effectiveness. Material and methods: A bibliographic research was made on the following databases: PubMed, Cochrane Library, Cochrane Library Plus, PEDro, Scopus, Web of Science, CINAHL and AMED. The studies must have been published in Spanish, English, French, Portuguese or Italian, and must have addressed vaginismus with one or more therapeutic modalities used by the physical therapy. Results: After inclusion and exclusion criteria were applied, and the titles and abstracts of the selected articles were analyzed, 6 studies were obtained; out of which, 3 were randomized clinical trials, 2 were uncontrolled prospective studies and 1 was a controlled non-randomized prospective trial. 2 of the randomized clinical trials were about electrotherapy and the other one was about manual therapy. One of the prospective studies analyzed the electrotherapy and the other one analyzed various therapies. The controlled non-randomized study studied the effects of combining various therapies. Conclusion: There's little evidence supporting physical therapy in the treatment of vaginismus. Although some studies demonstrate that physical therapy improves the functionality of the pelvic floor muscles and the sexual function, more investigations with a rigorous methodological quality are needed to establish the benefits that the physical therapy provides more specifically.

[gl] Obxectivo: Coñecer a evidencia actual existente sobre as intervencións de fisioterapia no tratamento do vaxinismo e comparar a súa eficacia. Material y métodos: Realizouse unha busca bibliográfica nas bases de datos PubMed, Cochrane Library, Cochrane Library Plus, PEDro, Scopus, Web of Science, CINAHL e AMED, de estudos publicados en español, inglés, francés, portugués ou italiano, que abordasen o vaxinismo cunha ou varias modalidades terapéuticas utilizadas en fisioterapia. Resultados: Tras aplicar os criterios de inclusión e exclusión e analizar os títulos e resumos dos artigos seleccionados, obtivéronse 6 estudos. Deles, 3 eran ensaios clínicos aleatorizados, 2 eran estudos prospectivos non controlados e 1 era un estudo prospectivo controlado non aleatorizado. No tocante aos ensaios clínicos aleatorizados, 2 falaban de electroterapia e 1 de terapia manual. Dos estudos prospectivos, 1 analizaba a electroterapia e 1 varias terapias. O estudo controlado non aleatorizado estudaba os efectos de varias terapias combinadas. Conclusión: Existe pouca evidencia que apoie á fisioterapia no tratamento do vaxinismo. Aínda que algúns estudos evidencian que a fisioterapia mellora a funcionalidade dos músculos do solo pelviano e a función sexual, son necesarias máis investigacións dunha calidade metodolóxica rigorosa para poder determinar máis concretamente os beneficios que esta aporta.
[en] Conservation of our natural areas more valuable is becoming a need not only ecologic or ethical, also socioeconomic, as in the right use of resources is the key of sustainable development. Courel is one of the zones more emblematic of Galicia. It's our "Mother Land" because in its woods and valleis takes root our imaginary colective of pristine Nature. Protection of its impoderable values is basic firstly for the comunities that live in it, but also for all the gallicians. Its conservation strategies will be obligated to frame into the plans that allow a honorable life for its population, without its natural or cultural riches will be affected. And I put special emphasis in this couple nature-culture like guide in the later reflexions around the central duo of this work: conservation-development

[gl] A conservación das nosas áreas naturais máis valiosas estase a convertir nunha necesidade non só ecolóxica ou ética, tamen socioeconómica, pois no correcto manexo dos recursos está unha das chaves do desenvolvemento sostible. O Courel é unha das bisbarras máis emblemáticas da Galiza. É a nosa "Terra Matria" porque nos seus bosques e vals enraiza o noso imaxinario colectivo da Natureza prístina. A protección dos seus imponderables valores é fundamental primeiramente para as comunidades que o habitan, pero tamén para todos os galegos e galegas. As súas estratexias de conservación deberán encadrarse dentro de Plans que permitan unha vida digna para os seus habitantes, sen menoscabo das súas riquezas naturais e culturais. E fago fincapé neste binomio natureza-cultura como guía nas reflexións posteriores en torno ao dúo central deste traballo: conservación-desenvolvemento
[en] This thesis project tries to identify genetic variants capable of altering the risk of developing the rapidly progressive phenotype in knee osteoarthritis. To achieve this, sequencing techniques have been used to search for polymorphisms present in nuclear and mitochondrial DNA that may favor the development of the phenotype of interest. A mitochondrial variant, present at m.16519C, was detected and was significantly associated with rapid progression. After carrying out a small functional study, higher levels of interleukin 6 and cyclooxygenase 2 were detected in cybrids carrying this variant, and the increased inflammatory response could be a triggering mechanism for rapid progression. On the other hand, an interaction between nuclear and mitochondrial DNA has been detected for the first time in the field of osteoarthritis. The presence of the mitochondrial haplogroup UK and the rs12107036 nuclear polymorphism also increases the risk of rapid progression in knee osteoarthritis. Finally, a predictive model of great clinical and pharmacological relevance was generated, based on genetic and clinical variables, which is capable of predicting the risk of developing the rapidly progressive phenotype of knee osteoarthritis.

[gl] Esta tese de doutoramento trata de identificar variantes xenéticas capaces de alterar o risco de desenvolver o fenotipo de artrose de xeonllo con progresión rápida. Para iso utilizáronse técnicas de secuenciación para atopar polimorfismos presentes no ADN nuclear e mitocondrial que poidan favorecer o desenvolvemento do fenotipo de interese. Detectouse unha variante mitocondrial, presente na posición m.16519C, que estivo significativamente asociada coa rápida progresión. Despois de realizar un pequeno estudo funcional, detectáronse niveis máis altos de interleucina 6 e cicloxixenasa 2 nos cíbridos portadores da variante, indicando que, o aumento da resposta inflamatoria podería ser un mecanismo desencadeante para unha progresión rápida. Por outra banda, detectouse por primeira vez unha interacción entre o ADN nuclear e o mitocondrial no campo da artrose. A presenza do haplogrupo mitocondrial UK e do polimorfismo nuclear rs12107036 tamén aumenta o risco de progresión rápida na artrose do xeonllo. Por último, xerouse un modelo preditivo de gran relevancia clínica e farmacolóxica, baseado en variables xenéticas e clínicas capaces de predecir o risco dun individuo de desenvolver o fenotipo de artrose de xeonllo con progresión rápida.
[en] This doctoral thesis analyses the school experiences of migrant adolescents enrolled in Compulsory Secondary Education in Galicia in terms of time use. It explores the notion that migration and education are structured around the family, and that although the seo pe is callective, minors' time uses are based on individuality. In accordance with these principies, I considered two hypotheses: asymmetrical time uses of migrant and nonmigrant pupils may lead to educational disadvantage; and the home and the State playa key role in shaping these school experiences. In order to prove these hypotheses, I set three objectives: to analyse the life time use of the adolescents in aceordanee with their (migrant or non-migrant) origins; to cansider the inlluenee 01 the migrant household on the use and distribution 01 their sehool time; and thirdly, to study the impaet 01 education poliey on their everyday lives. Using a mixed methodology, two surveys 01 eontrasting scape and context were eondueted, and in-depth interviews were held with experts related to edueation. The results reveal the edueational disadvantage 01 the migrant group, attributable mainly to their migrant status and lower social class.

[gl] Esta tese de doutoramento analiza as experiencias escolares das adolescencias migrantes matriculadas en Ensinanza Secundaria Obrigatoria, en clave de usos do tempo. Da canta de que a migración e a educación vertébranse ao redor da familia, e de que os usos do tempo dos/as menores parten da individualidade, pero teñen un alcance colectivo. Desde estes fundamentos, se plantexan dúas hipóteses: validar a existencia de asimetría nos usos do tempo do alumnado migrante e non migrante, que pode derivar en desvantaxe educativa; e validar a importancia que o fogar e o Estado teñen nesas experiencias escolares. Para proba lo, establécense tres obxectivos: analizar os usos do tempo de vida dos/ as adolescentes, segundo a súa procedencia (migrante ou non migrante); abordar a influencia que o fogar migrante exerce no uso do seu tempo escolar; e, por último, estudar o impacto que a política educativa ten nas súas cotidianeidades. Cunha metodoloxía mixta, aplicáronse dúas enquisas de diferente alcance e contexto, e realizáronse entrevistas en profundidade a expertos/ as vinculados/ as coa institución educativa. Os resultados evidencian experiencias de desvantaxe educativa no colectivo migrante que, fundamentalmente, explícanse pala súa condición de migrante e clase subalterna.
[en] This article deals with the problems faced by exiled primary school teachers purged by Franco's regime after 1936. Of the two variations that may be focussed on to approach this issue -domestic exile and exile abroad- this analysis centres on the latter, oftentimes as it relates to the former. Starting from its terminological conceptualisation, domestic exile is analysed along with its characteristics, forms and manifestations. The refe- rences to the characteristics and kinds of domestic exile experienced by Galician school tea- chers are based on the research carried out by the author. This led to the publication of the book entitled Historias de vida (2003).

[gl] O presente traballo aborda a problemática do exilio dos mestres e mestras gale- gos depurados polo réxime franquista a partir de 1936. Das dúas variantes que se amosan como potentes para tratar este tema, o exilio exterior e o exilio interior, o estudo céntrase na segunda acepción, a miúdo en relación coa primeira. A partir da conceptualización ter- minolóxica, analízase o exilio interior, as súas características, formas ou modalidades. As referencias ás características e variedades de exilio interior dos mestres e mestras galegos baséanse nunha investigación realizada polo autor, que deu lugar á publicación Historias de vida (2003).