BSC-LT/ACAData huggingface dataset:
[en] Cancer in Spain continues to increase significantly as indicated by the incidence and mortality curves up to 2040, so research is essential to find new drugs for its treatment. Cancer is a group of diseases that, at a subcellular level, have common hallmarks and among them is energy deregulation, through aerobic glycolysis, which is an important source of energy production for intense biosynthesis available to tumor cells. The inhibition or decrease of energy production through the inhibition of glycolysis enzymes may be an important source of new drugs for the future. To carry out this process, in this work, receptors with high pharmacological affinity are searched for in the enzymes, and of these, those that have ligands to search for drug precursor molecules by similarity. Enzymatic inhibition is based on the uncompetitive type (receptors and ligands are outside the catalytic active center) and with the help of bioinformatic techniques, such as ligand similarity and virtual molecular screening, precursor molecules are sought. Suitable enzyme molecules are located in the PDB data base and processed with several specialized bioinformatics programs (Proteins.Plus) for receptor search. Regarding the ligands, other specific programs are used such as: Swissimilarity, PyrX, AutodockVina, MOE.

[gl] O cancro en España segue aumentando significativamente como indican as curvas de incidencia e mortalidade ata 2040, polo que a investigación é fundamental para atopar novos fármacos para o seu tratamento. O cancro é un grupo de doenzas que, a nivel subcelular, teñen señas de identidade comúns e entre elas está a desregulación enerxética, mediante a glicólise aeróbica, que é unha importante fonte de produción de enerxía para unha intensa biosíntese dispoñible para as células tumorais. A inhibición ou diminución da produción de enerxía mediante a inhibición dos encimas da glicólise pode ser unha fonte importante de novos fármacos para o futuro. Para levar a cabo este proceso, no presente traballo, búscanse nos encimas receptores con alta afinidade farmacolóxica, e destes, aqueles que posúen ligandos para buscar moléculas precursoras de fármacos por semellanza. A inhibición enzimática baséase no tipo acompetitivo (receptores e ligandos están fóra do centro activo catalítico) e coa axuda de técnicas bioinformáticas, como a semellanza de ligandos e o cribado molecular virtual, búscanse moléculas precursoras. As moléculas enzimáticas adecuadas están localizadas na base de datos PDB e procesadas con varios programas bioinformáticos especializados (Proteins.Plus) para a busca de receptores. En canto aos ligandos, utilízanse outros programas específicos como: Swissimilarity, PyrX, AutodockVina, MOE.
[en] For the normal life and health of the population of each country becomes important at the present time, the quality and ecological assessment of water. Water is essential for normal physiological processes of the body. Due to the need to identify specific physico-chemical parameters of water and to carry out a comprehensive assessment of the state of drinking water in Absheron region in Azerbaijan, as research object was chosen the Ceyranbatan reservoir. The study was conducted to evaluate the chemical composition, as well as its compliance with drinking water quality standards. The structure of the thesis consists of an introduction, four chapters and conclusions. The first chapter is devoted to water, its composition and its effects on human health. In the second chapter deals with standards and hygienic requirements for drinking water quality. The third chapter deals with diseases caused by chemical composition of water. The fourth final chapter focuses on the physical-chemical water reservoir Ceyranbatan research, determining more than forty parameters including heavy metals. Effect of the water purification treatment in certain parameters was studied, analyzing the water before and after the cleaning treatment, in autumn and winter. Water samples analyzed comply with all standards and hygienic requirements for the quality of drinking water, demonstrating a highly efficient operation of the Ceyranbatan water treatment plant.

[gl] Actualmente considérase de gran importancia a calidade e a avaliación ecolóxica da auga para a vida normal e a saúde da poboación dun país. A auga é esencial para os procesos fisiolóxicos normais do organismo. Este traballo de fin de máster expón como obxectivo principal de investigación a necesidade de identificar os parámetros físico-químicos específicos e realizar unha avaliación exhaustiva do estado da auga potable na rexión de Apsherón en Azerbaiyán, para o que se seleccionou o encoro de Ceyranbatan. No traballo estudouse a composición química da auga, así como o grao de cumprimento dos estándares de calidade da auga potable.A estrutura da tese de máster consta dunha introdución, catro capítulos e conclusións. O primeiro capítulo está dedicado á auga, a súa composición e os seus efectos sobre a saúde humana. O segundo capítulo ocúpase das normas e requisitos de hixiene para a calidade da auga potable. O terceiro capítulo considera as enfermidades causadas pola composición química da auga. O cuarto capítulo final céntrase na investigación físico-química da auga do encoro Ceyranbatan, determinando máis de corenta parámetros, entre os que se atopan os metais pesados. Estudouse o efecto do tratamento de potabilización da auga nos parámetros determinados, analizando a auga antes e despois do tratamento de limpeza, no outono e no inverno. As mostras de auga analizadas cumpren con todas as normas e requisitos de hixiene para a calidade da auga potable, demostrando unha operación altamente eficiente da potabilizadora de Ceyranbatan.
[en] Classical analysis of time-to-event data assumes that all individuals will eventually experience the event of interest. However, when there is evidence of long-term survivors, cure models should be used instead. They assume that the population of individuals is made up of two distinct groups: those who will and those who will not experience the event. A common assumption in cure models is that there is no additional information about the cure status, and the cure indicator is modelled as a latent variable. But this is not entirely valid in many cases, when some censored individuals can be identified as cured, for example, based on a diagnostic test or if the observed lifetime is larger than a cure threshold. Mixture cure models have been usually estimated using parametric or semiparametric models. Recently, a completely nonparametric approach was introduced under the classical assumption that the cure status in unknown. This PhD thesis proposes a novel extension of nonparametric mixture cure models to incorporate the additional information about the cure status. Suitable nonparametric estimators for the main functions are proposed, together with a rough procedure for checking the validity of the model.

[gl] Os métodos clásicos de análisis de tempos de vida asumen que todos os individuos experimentarán o suceso de interese. Con todo, cando hai evidencia da presenza de supervivientes a longo prazo ou curados, deberansen usar no seu lugar os modelos de curación. Estes asumen que a poboación de individuos pódese dividir en dous grupos: os que experimentarán o suceso e os que non. Cando se aplican os modelos de curación, asúmese que para os individuos censurados non se dispón de información adicional sobre o estado de cura, e o indicador de cura se modeliza en consecuencia como unha variable latente. Mais isto non é necesariamente certo en moitos casos, nos que algúns individuos censurados pódense identificar como curados, baseándose por exemplo nun test diagnóstico ou se o tempo de vida supera un determinado valor. Os modelos de curación de tipo mixtura estimáronse normalmente usando técnicas paramétricas ou semiparamétricas. Recentemente propúxose un enfoque completamente non paramétrico para os modelos de curación de tipo mixtura, baixo a hipótese clásica de que se descoñece completamente se un individuo está curado. Esta tese propón unha extensión aos modelos non paramétricos de curación de tipo mixtura, na que se incorporará información adicional dispoñible sobre o estado de cura. Propóñense estimadores non paramétricos das principais funcións, así como un posible procedemento para avaliar a validez do modelo.
[en] Under the title The anti-Galician stereotype in modern Spanish literature: genesis, development and consolidation, this doctoral thesis analyses the negative image associated with Galicia and the Galician people in the Spanish literary production between the 16th and the 19th centuries. In order to integrate the different reflections and studies dedicated to the anti-Galician sentiment and to the modern anti-Galician stereotype, especially numerous since the second half of the 20th century, this research is developed within the framework of multidisciplinary approach to this stereotypical phenomenon through an eminently heterogeneous documentary corpus. From this perspective, those postulates and theories emanating from social psychology acquire special significance in this study, since they allow us to draw parallels between the Galician case and other ethnic and/or national groups, particularly in the field of centre-periphery relations. In addition to manifesting the existence of a stereotype of the "Other", marked by fundamentally negative characteristics from a social point of view, the textual analysis points to a confluence of various cultural, socio-economic and political factors as the origin and conformation of the modern anti-Galician stereotype. The influence exerted by these elements on the Collective Castilian imaginary, and later Spanish, as well as its determinative context, leads us to a global understanding of the anti-Galician stereotype through different stages and/or periods.

[gl] Baixo o título de O estereotipo antigalego na literatura española moderna: xénese, desenvolvemento e consolidación, a presente tese de doutoramento analiza a imaxe negativa que acompañou a Galiza e o pobo galego na produción literaria española entre os séculos XVI e XIX. A fin de integrar as diferentes reflexións e estudos dedicados á galaicofobia e o estereotipo antigalego moderno, especialmente numerosos desde a segunda metade do século XX, esta investigación desenvólvese no seo da multidisciplinariedade ao abordar este fenómeno estereotípico a través dun corpus documental nomeadamente heteroxéneo. Baixo esta perspectiva, cobran especial significado neste estudo aqueles postulados e teorías emanados da psicoloxía social, por canto permiten estabelecer paralelismos entre o caso galego e outros grupos étnicos e/ou nacionais, singularmente no eido das relacións centro-periferia. Para alén de manifestar a existencia dun estereotipo do Outro, marcado por características notadamente negativas dun punto de vista social, a análise textual apunta a unha confluencia de diversos factores culturais, socioeconómicos e políticos como orixe e conformación do estereotipo antigalego moderno. A influencia exercida por estes elementos no imaxinario colectivo castelán −e posteriormente español−, así como o seu contexto determinativo, condúcenos a unha comprensión global do estereotipo antigalego a través de diferentes estadios e/ou períodos.
[en] Arbitration between States and foreign investors is a dispute-resolution mechanism halfway between international public Law and private Law, which had surprisingly rised during the 1990's at the world level. In this work the following issues will be tackled: the legal nature of the aforementioned arbitrators. ICSID -International Centre for the Settlement of Investments Disputes- is a modality of institutional arbitration for investments. This institution is incarditated into the World Bank Group. The aim of this dissertation is to carry out a research on the configuration of the independence and impartiality of ICSID arbitrators, as well as their duties and rights as such and their procedural faculties. The research will be based on both national and international comparative Law, focusing in legal doctrine, in praxis and in the law governing the ICSIS system.

[gl] A arbitraxe entre Estados e particulares estranxeiros é un mecanismo de resolución de controversias a cabalo entre o Dereito internacional público e o Dereito privado, que dende finais da década de 1990 viviu un sorprendente auxe a nivel mundial. Unha modalidade de arbitraxe institucional de investimentos é a do CIADI -Centro Internacional para o Arranxo de Desputas sobre Investimentos-, organismo dependente do Grupo do Banco Mundial. O propósito da tese é facer unha investigación sobre a independencia e imparcialidade dos árbitros do CIADI, os seus dereitos e deberes como tales e as súas facultades procesuais. A investigación valerase do Dereito Comparado, tanto nacional como internacional, realizando unha análise da doutrina, a práctica e a lexislación que regula o sistema CIADI.
[en] The legal status and trends of the enforcement of judgments in the Spanish American administrative process, with particular reference to Spain, Peru, Costa Rica, Colombia and Venezuela is studied. Starts referring overcoming legal and objective reviewer of administrative litigation and its replacement by the notion of administrative procedural claim. Then the various types of statements in the administrative process and its effects are described, and then address some of the fundamental problems in the subject: declarative replacement and executive judge and judicial review of discretionary powers of the Administration, inactivity and material activity. Exhibited this theoretical framework, the regulation of such categories in the laws under study is analyzed, as well as regimes enforcement of judgments that condemn the Public Administration to pay amounts of money and the enforcement of court decisions by a third with its peculiarities and progress. Then the current regime and trends downsizing procedural prerogatives of public administration, especially prohibition of seizure of public property described. It concludes by pointing out the commonalities and differences between the various legislations under study.

[gl] Estúdase o réxime legal e as tendencias da execución das sentenzas no proceso administrativo iberoamericano, con especial referencia a España, Perú, Costa Rica, Colombia e Venezuela. Inicia referindo a superación legal do carácter revisor e obxectivo do contencioso-administrativo e a súa substitución pola noción de pretensión procesual administrativa. Seguidamente descríbense os diversos tipos de sentenzas no proceso administrativo e os seus efectos, para logo abordar varios dos problemas fundamentais no tema: a substitución declarativa e executiva do xuíz, así como o control xudicial das potestades discrecionales da Administración, da inactividade e da actividade material. Exposto ese marco teórico, analízase a regulación de tales categorías nas leis baixo estudo, así como os réximes de execución das sentenzas que condenan á Administración Pública a pagar cantidades de diñeiro e a execución das decisións xudiciais a cargo dun terceiro, coas súas peculiaridades e avances. A continuación descríbese o réxime actual e as tendencias ao redimensionamiento das prerrogativas procesuais da Administración Pública, especialmente a inembargabilidad de bens públicos. Conclúese sinalando os puntos comúns e as diverxencias entre as diversas lexislacións baixo estudo.
[en] The aim is to determine the prevalence of chronic obstructive pulmonary disease (COPD) and to describe the quality of life, the physical activity and the level of misdiagnosis. Social, demographic and clinical information were collected; also health-related quality of life (HRQL) (SF-36), physical activity (IPAQ) and pulmonary function (spirometry tests) were also undertaken. The COPD prevalence was 5,7%, was higher in men (8,6%) and increased with age (13,6% in 60-64 years group) and with cigarette smoking (11,7% in smokers). Age, sex (male), pack-years, dyspnea and chronic cough/sputum production were associated with the presence of COPD. A previous diagnosis or COPD was presented only in 20,4% of those with COPD. COPD was significantly related to a lower physical activity. Although the presence of COPD reduced the HRQL in the physical component summary, it did not do so significantly. The prevalence of COPD in adults is 5,7%, which raises with increased age, tobacco consumption and in male sex. The rate of misdiagnosis in COPD is very high. Individuals with COPD already have a significant impairment in physical activity performance and a lower HRQL.

[gl] Pretendese determinar a prevalencia da enfermidade pulmonar obstrutiva crónica (EPOC), e describir a calidade de vida relacionada coa saúde, a actividade física e o nivel de discordancia coa historia clínica. Recolleuse información sociodemográfica/clínica, da calidade de vida relacionada coa saúde (CVRS) (SF-36), da atividade física (IPAQ) e da función pulmonar (espirometría forzada). A prevalencia da EPOC foi do 5,7%, máis elevada nos homes (8,6%) e aumentou coa edade (13,6% na franxa de poboación 60-64 anos) e co consumo de tabaco (11,7% en fumadores). O diagnóstico previo de EPOC só estaba presente no 20,4% dos casos. A edade, sexo (masculino), paquetes-ano, disnea e tose/expectoración crónica estaban asociadas coa presenza de EPOC. A EPOC relacionouse coa menor actividade física. Aínda que en presenza da EPOC se reducía a CVRS no compoñente físico, non foi significativo. A prevalencia da EPOC en adultos é do 5,7%, e aumenta coa maior edade, consumo de tabaco e no sexo masculino. O nivel de discordancia co diagnóstico é moi alto. A EPOC relacionase, significativamente, con unha menor actividade física e unha menor calidade de vida no compoñente físico.
[en] With the objective of contributing to the recovery of the Iberian Imperial Eagle, one of the birds of prey which is most under threat in Europe, rife in the Iberian Peninsula and "In Danger", the SEO Bird Life organization developed the campaign known as "Flying Off", which is strucyured into three major lines of action, that is, management of the habitat, protection and participation, and informing the public opinion and providing information. In order to carry out these lines of action and to reach the objective of contributing to the protection of the Iberian Imperial Eagle, there exists a great need for the use of the social instruments of communication, informing the public opinion, participation and education

[gl] Co obxectivo de contribuír á recuperación da aguia imperial ibérica, unha das rapaces máis ameazadas de Europa, endémica da península Ibérica e "en perigo", SEO/BirdLife desenvolve o Programa Alzando o Voo, estruturado en tres grandes liñas de actuación, xestión de hábitat, conservación e participación e sensibilización e difusión. Para levar a cabo estas liñas de traballo e alcanzar o obxectivo de contribuír á conservación da aguia imperial ibérica faise imprescindible o uso dos instrumentos sociais de comunicación, sensibilización, participación e educación
[en] Objectives: To determine the prevalence of podiatric pathology in people with breast cancer undergoing chemotherapy and to explore their general quality of life regarding foot health, functionality and foot pain, and their associated variables. Methodology: Observational, cross-sectional, descriptive study of prevalence (Breast Unit and Department of Oncology of the University Hospital of A Coruña, Spain). People with breast cancer, over age, and undergoing chemotherapy were studied (n=117; ±9% accuracy, 95% confidence). Sociodemographic, disease and podiatric variables were studied. Questionnaires were used to the study of quality of life, functionality and foot pain. Current ethical-legal aspects were followed. Results: Podiatric pathology was very prevalent and diverse. 77.8% presented foot pain and 38.6% needed to delay chemotherapy treatment due to podiatric adverse effects. Aspects related to footwear and foot health stand out as the most affected in the questionnaires studied. Conclusions: Podiatric adverse effects represent health problems of great relevance for the quality of life. Further research in foot health care from a holistic and comprehensive perspective in Podiatry is needed.

[gl] Obxectivos: Determinar a prevalencia da patoloxía podolóxica en persoas con cancro de mama que reciben quimioterapia e explorar a súa calidade de vida relacionada coa saúde, funcionalidade e dor dos pes, e as súas variables asociadas. Metodoloxía: Estudo observacional, transversal, descritivo de prevalencia (Unidade de Mama e Servizo de Oncoloxía do Hospital Universitario da Coruña, España). Estudáronse persoas con cancro de mama, maiores de idade, recibindo quimioterapia (n=117; precisión ±9%, confianza 95%). Investigáronse variables sociodemográficas, da enfermidade e podolóxicas. Empregáronse cuestionarios para o estudo da calidade de vida, funcionalidade e dor do pé. Seguíronse os aspectos ético-legais vixentes. Resultados: A patoloxía podolóxica foi moi frecuente e diversa. O 77,8% presentaron dor podolóxico e o 38,6% precisaron retrasar a quimioterapia debido aos efectos adversos no pé. Aspectos asociados co calzado e a saúde do pé destacan como os mais afectados nos cuestionarios estudados. Conclusións: Os efectos adversos podolóxicos representan problemas de saúde de gran relevancia para a calidade de vida. Requírese desenvolver máis investigacións e implicarse no coidado da saúde dende unha perspectiva holística e integral dende a mirada da Podoloxía.
[en] This work deals with the time that the woman devotes to work which has to be measured under principles of equality between men and women. In this study we examine the indicators used to measure the time of work. As the most frequent indicator in the participation in the labour trength is the number of women and men economically active. This measurement is carried out through the system of national accounts according to which the economic activity includes all work inside the limit of production. In this work we show that until the present the work of the woman in specific activities has not been included and that this should be integrated as a means of mitigating poverty and achieving a greater degree of equality

[gl] Este traballo trata sobre o tempo que a muller dedica ao traballo, o cal ha de ser medido baixo principios de igualdade entre homes e mulleres. Estúdanse os indicadores para medir o tempo de traballo, dos cales o máis frecuente é a participación na forza laboral, o número de mulleres e homes economicamente activos. Esta medición lévase a cabo a través do sistema de contas nacionais, segundo as cales a actividade económica inclúe todo traballo dentro dos limites de produción. Neste traballo sinálase que até agora non se incluíu dentro delas o traballo da muller en determinadas actividades e que debería ser integrado como medida para paliar a pobreza e conseguir maiores cotas de igualdade.