BSC-LT/ACAData huggingface dataset:
[en] The pediatric obesity is a significant risk factor for multiple illnesses, and far from disappearing, the number of children under this condition stays on the rise. It therefore becomes essential to identify all those children who can be affected, in order to provide them personalized care, reducing in this manner the prevalence of the pediatric obesity. Based on this principle and after an exhaustive bibliographic search, a population screening through the consignment of letters to the potential beneficiaries is proposed, with the intention that they compute their Body Mass Index (BMI), so that if its value indicates overweight or obesity, they resort to their nursing clinic to receive the adequate support.

[gl] A obesidade infantil é un importante factor de risco de múltiples enfermidades e lonxe de desaparecer, o número de nenos diagnosticados continúa á alza. Por elo convértese en indispensable identificar a todos aqueles posibles afectados co fin de proporcionarlles uns coidados individualizados, reducindo así a prevalencia de obesidade infantil. Baixo esta premisa e realizando unha busca bibliográfica exhaustiva, proponse a realización dun cribado baseado no envío de cartas aos potenciais beneficiarios, coa intención de que calculen o seu Índice de Masa Corporal (IMC), de maneira que se o valor deste é indicativo de sobrepeso ou obesidade acudan á consulta de enfermería do seu Centro de Atención Primaria para recibir asistencia por parte dun profesional.
[en] The emergence and spread of resistance to antimicrobial agents has accelerated in recent years, causing a global health crisis and highlighting the urgent need to develop more effective new drugs. In the present work, the synthetic development of a siderophoreantibiotic conjugate following a "Trojan Horse" strategy was proposed, as well as the construction of a fluorescent probe to study the mechanisms involved in the recognition and internalization processes, using in both cases a linker longer than that used in previous studies. The selected entry vector was an analog of amonabactins, a siderophore of the pathogenic bacterium Aeromonas salmonicida subsp. salmonicida with which it was intended to take advantage of the iron uptake mechanism to promote the active absorption of the antibiotic (ampicillin) and the fluorophore (sulforhodamine B). The work carried out allowed the obtaining of a siderophore-antibiotic conjugate, however, its characterization showed the presence of other compounds that indicated the possible degradation of the product. These results show the need for new studies to obtain it with a higher degree of purity. Furthermore, functionalization of the spacer with the necessary reactive groups to form the fluorescent probe was achieved, but coupling with sulforhodamine B did not give the expected results.

[gl] A aparición e propagación de resistencias fronte os axentes antimicrobianos viuse acelerada nos últimos anos, provocando una crise sanitaria a nivel mundial e poñendo de manifesto a necesidade urxente de desenvolver novos fármacos mais efectivos. No presente traballo propúxose o desenvolvemento sintético dun conxugado sideróforoantibiótico seguindo unha estratexia tipo "cabalo de Troia", así como a construción dunha sonda fluorescente para estudar os mecanismos implicados nos procesos de recoñecemento e internalización, empregando en ambos casos un espaciador de maior lonxitude ao utilizado en estudos previos. O vector de entrada seleccionado foi un análogo das amonabactinas, un sideróforo da bacteria patóxena Aeromonas salmonicida subsp. salmonicida co que se pretendía aproveitar o mecanismo de captación de ferro para promover a absorción activa do antibiótico (ampicilina) e o fluoróforo (sulforodamina B). O traballo desenvolto permitiu a obtención dun conxugado sideróforo-antibiótico, non obstante, a súa caracterización evidenciou a presencia doutros compostos que indicaron a posible degradación do produto. Estes resultados mostraron a necesidade de realizar novos ensaios que permitan a súa obtención cun maior grado de pureza. Ademais, conseguiuse a funcionalización do espazador cos grupos reactivos necesarios para formar a sonda fluorescente, pero o acoplamento coa sulforodamina B non deu os resultados esperados.
[en] Acinetobacter baumannii is a nosocomial pathogen that presents great genetic plasticity and antimicrobial resistance frequently implied hospital outbreaks difficult to control. The study of the genome of this pathogen allows us to select the most interesting genes as possible therapeutic targets. This Thesis presents a global transcriptomic analysis of bacterial RNA isolated directly from the lungs of mice infected with A. baumannii, in order to identify those genes involved in the development of pneumonia infection. hisF and lpxB genes were found to be overexpressed during infection. HisF is involved in lung persistence due to inhibition of macrophage recruitment and IL-6 production by the host. The translation of LpxB, the essential protein involved in the synthesis of LPS, has been inhibited using antisense technology. Colistin, an antibiotic with a high toxicity, is mainly used in the treatment of multi-resistant strains and is considered the last therapeutic option. MD3 is a SPasas inhibitor that presents synergy with colistin, thus being a promising candidate in the treatment of infections caused by A. baumannii, including colistin-resistant strains. In vivo transcriptomic analysis allowed us to identify several genes as potential therapeutic targets and evaluated new strategies and antimicrobial compounds for the treatment of A. baumannii.

[gl] Acinetobacter baumannii é un patóxeno nosocomial que presenta unha gran plasticidade xenética e resistencia antimicrobiana frecuentemente implicado en brotes hospitalarios difíciles de controlar. O estudo do xenoma deste patóxeno permítenos seleccionar aqueles xenes máis interesantes como posibles dianas terapéuticas. Nesta Tese preséntase unha análise transcriptómica global do ARN bacteriano illado directamente dos pulmóns de ratos infectados con A. baumannii, coa finalidade de identifica-los xenes implicados no desenvolvemento da infección. Os xenes hisF e lpxB atopáronse sobreexpresados durante a infección. HisF atópase implicado na persistencia en pulmón pola inhibición do reclutamento de macrófagos e da producción de IL-6 por parte do hospedador. A traducción de LpxB, proteína esencial implicada na síntese de LPS, foi inhibida empregando tecnoloxía antisentido A colistina, antibiótico cunha elevada toxicidade, emprégase principalmente no tratamento de cepas multirresistentes e é considerado de última opción terapéutica. O MD3 é un inhibidor de SPasas que presenta sinerxia coa colistina, sendo así un candidato prometedor no tratamento de infeccións causadas por A. baumannii, incluindo cepas resistentes a colistina. A análise transcriptómica in vivo permitiunos identificar unha serie de xenes como dianas terapéuticas potenciais e avaliáronse novas estratexias e compostos antimicrobianos para o tratamento de A. baumannii.
[en] Understanding the origins and evolution of a settlement through time is intrinsically bound to the analysis of the relation with existing water resources in the surroundings. In the case of A Coruña this connection has always been determined by the geographical landmark where the city is located, a peninsula, and the lack of freshwater. This led the city to build two aqueducts to supply the inhabitants with freshwater from the sixteenth century on. These water systems were known as the aqueducts of Vioño and San Pedro de Visma. The present paper shows the research carried out about these two projects and their history, their layout, their transformations through time and their decay, as well as an analysis of their influence on the past and present urban tissue, mainly based on historical cartography.

[gl] Comprender a orixe e evolución dun asentamento no tempo está intrínsecamente ligado á análise de cómo este se relaciona coa auga do seu entorno. No caso da Coruña este vínculo estivo sempre marcado polo seu carácter de península e a escaseza de auga doce, o que provocou que, a partir do século XVI, a cidade fose dotada de dous acueductos para abastecer á poboación: as viaxes de auga de Vioño e de San Pedro de Visma. No presente traballo realizamos un estudo destes dous proxectos e a súa longa traxectoria histórica, o seu trazado planificado, as súas transformacións no tempo e o seu proceso de desaparición, así como unha análise da súa influencia sobre a trama da cidade, pasada e contemporánea, a través fundamentalmente de fontes cartográficas.
[en] Phytophthora capsici is a pathogen of great plasticity, with several hosts. One of the is bean, a widely grown and economically important plant. Therefore, it is necessary to study the diseases of bean to control them. The objectives of this study are to test whether exogenous application of benzylaminopurine to the leaves of bean confers resistance against to P. capsici, and if this treatment causes variations in the levels of phenols, a group of compounds related to defensive response.The data obtained showed a decrease in the diseased area of plants that were induced with benzylaminopurine, that was more noticeable at the local level than the systemic level. On the other hand, the analysis of phenolic compounds revealed a decrease in the plants treated with benzylaminopurine, compared to non-induced plants. Taking into account these data, it is concluded that benzylaminopurine induces local and systemic resistance against infection with Phytophthora capsici.

[gl] Phytophthora capsici é un patóxeno de gran plasticidade que conta con varios hóspedes, entre os cales se atopa o feixón (Phaseolus vulgaris), unha planta ampliamente cultivada e de grande importancia económica, polo que se fai necesario o estudo das súas enfermidades para poder facer fronte ás mesmas. Os obxectivos deste traballo son comprobar se a aplicación esóxena de bencilaminopurina nas follas da planta do feixón confire resistencia fronte a P. capsici, así como se este tratamento vai provocar variacións nos niveis de fenois, un grupo de compostos relacionados coa resposta defensiva. Os datos obtidos mostraron unha diminución da área enferma nas plantas que foron inducidas con bencilaminopurina, que resultou ser máis notoria a nivel local que sistémico. Por outra banda o análise de compostos fenólicos revelou unha diminución nos mesmos nas plantas tratadas con bencilaminopurina, en comparación coas plantas non inducidas. Tomando estes datos como base, concluiuse que a bencilaminopurina vai inducir resistencia a nivel local e sistémico fronte á infección con Phytophthora capsici.
[en] Case presentation: We describe the case of a 56-year-old male referred to the Univer-sity Clinic of Podiatry (CUP) of the University of A Coruña derived from Primary Care for a check-up and treatment of nail changes in his feet. Assessment: Presence of red-orange palmoplantar keratoderma and erythroderma with some scaling and follicular hyperkeratosis in the extremities, trunk, and facial area. Due to the broad extension of the skin condition, he was referred to the Ferrol Naval Hospital Dermatology Service. Action plan: Initially, in the Dermatology Department, emollients, 5% salicylated Vase-line and oral prednisone were prescribed; At the same time, the Podiatry Service per-forms cutting and milling of nails and delamination of hyperkeratosis. Subsequently, the ineffectiveness of the treatment was observed and an adenocarcinoma of the sigmoid was discovered, for which treatment with apremilast was started. Discussion: Pityriasis rubra pilaris (PRP) can manifest with different clinical presenta-tions, which will determine the treatment and prognosis. In addition, with the arrival of COVID-19, cases of PRP associated with the COVID-19 vaccination process were ob-served, or after testing positive for COVID-19 diagnostic tests.

[gl] Presentación do caso: Descríbese o caso dun home de 56 anos de idade que acudiu a Clínica Universitaria de Podoloxía (CUP) da Universidade da Coruña para unha revi-sión e tratamento de trastornos ungueais nos pes. Valoración: Presenza de queratodermia palmoplantar de cor vermello laranxado e eri-trodermia consistente con algunha descamación e hiperqueratose folicular nas extremi-dades, tronco e zona facial. Pola extensión da afección cutánea foi derivado ao Servizo de Dermatoloxía do Hospital Naval de Ferrol. Plan de actuación: Inicialmente, no Servizo de Dermatoloxía prescribíronse emolientes e vaselina salicilada ao 5%, asociados a un réxime oral de prednisona; Paralelamente, no Servizo de Podoloxía realizase o corte e fresado de uñas e a delaminación da hiperqueratose presente. Posteriormente, observouse a ineficacia do tratamento e descu-briuse un adenocarcinoma de sigmoide, para o que se iniciou o tratamento con apremi-last. Discusión: A pitiriasis rubra pilaris (PRP) pode manifestarse con diferentes presenta-cións clínicas, que determinarán o tratamento e o prognóstico. Ademais, coa chegada da COVID-19, observáronse casos de PRP asociados ao proceso de vacinación contra a COVID-19, ou tras dar positivo nas probas diagnósticas de COVID-19.
[en] The long-term treatment breach in chronic diseases is a growing global problem, with negative clinical and economic consequences. Currently the adherence to the treatment in obese patients is considered by the lack of commitment to exercise and not follow a diet, however the scientific literature says that this phenomenon is multidimensional and is determined by five factors: socioeconomic ,related to the healthcare team, related to the disease, related to the treatment and related to the patient. Therefore, nursing plays an important role in detecting and acting on these factors to improve adherence to treatment. Objectives: The main objective is to know the factors that prevent a correct adherence to therapeutic treatment. Specific objectives are to raise awareness of the importance of nursing in the approach to this disease, assess the clinical relationship established between the patient and nursing, propose intervention strategies and assess the family influence on adherence. Methodology: A descriptive, observational cross-sectional study was carried out by: Life habits questionnaire related to overweight and obesity, Battle Test, FACES III questionnaire, Morisky - Green test, Haynes - Sackett test and the CICAA valuation scale.

[gl] O incumprimento do tratamento a longo prazo en enfermidades crónicas é un problema mundial crecente de gran magnitude que carrexa consecuencias clínicas e económicas negativas. Na actualidade, a adhesión ó tratamento en pacientes obesos é contemplada pola falta de compromiso no exercicio e non seguir unha dieta, mais a literatura científica refire que este fenómeno é multidimensional e está determinado pola acción conxunta de cinco factores: socioeconómico, relacionados co equipo de saúde, relacionados ca enfermidade, relacionados co tratamento e relacionados co paciente. Polo tanto, a enfermaría desempeña un papel importante na detección e actuación sobre estes factores para mellorar a adherencia ao tratamento. Obxectivos: O principal obxectivo é coñecer os factores que impiden a correcta adherencia do tratamento terapéutico. Como obxectivos específicos, búscase resaltar a importancia da enfermaría no tratamento desta enfermidade, avaliar a relación clínica establecida entre paciente e enfermería, propoñer estratexias de intervención e avaliar a influencia da familia sobre a adhesión. Metodoloxía: Estudo observacional, descritivo, realizado a través de: cuestionario de hábido de vida relacionado co exceso de peso e obesidade, test de Batalla, cuestionario FACES III, test de Morisky - Green, test de Haynes - Sackett e a escala de avaliación CICAA.
[en] The red thread is a pyridinium based cationic salt, derived from the viologen, in which the pyridinic unities are linked through a hydrazone bond. This result in the pH responsiveness of the compound, due to the NH acidity, and avoids the cytotoxicity problems of the redox response of the the viologen. Two derivatives of the red thread were synthesized, one with a longer chain and another with a shorter chain. To that end the same methodology was followed in both cases, starting from commercial reactives, through SN2 and SNAr reactions, two precursor compounds were obtained. Finally, by a hydrazone synthesis reaction, the final product was obtained, then purified by HPLC or metathesis. Next, the products were structurally characterized using the usual spectroscopic techniques, RMN 13C and 1H monodimensional and bidimensional, in their protonated and deprotonated form in organic medium. Then studies in aqueous medium were realized, in which the pKa was determined by potentiometry and UV-VIS, obtaining similar values to those already reported for the read thread. A tendency to aggregation was observed in the long chain derivative, in which the critical aggregation concentration (cac) could be determined by DLS. In basic medium the cac was obtained in lower concentrations than in acidic medium, thus proving the pH dependency.

[gl] O vermellóxeno é unha sal catiónica de piridinio, derivada do violóxeno, onde as unidades piridínicas únense mediante un enlace hidrazona. O cal permite que o composto responda ao pH, debido a acidez do NH, e evite os problemas de citotoxicidade da resposta redox do violóxeno. Sintetizáronse dous derivados do vermellóxeno, un de cadea longa e outro de cadea curta. Para iso, seguiuse a mesma metodoloxía en ambos os dous casos, a partir de reactivos comerciais, mediante reaccións SN2 e SNAr, obtivéronse primeiro os dous precursores necesarios. Despois, a través de una reacción de síntese de hidrazonas, obtívose o produto final, sendo purificado por HPLC o metátesis. A continuación, caracterizáronse estruturalmente coas técnicas habituais, RMN 13C y 1H monodimensional e bidimensional, na súa forma protonada e desprotonada en medio orgánico. Despois, realizáronse estudios en medio acuoso, onde se determinou o pKa por potenciometría e UV-VIS, obtendo valores similares aos xa reportados para o vermellóxeno. Observouse tendencia á agregación no derivado de cadea larga, podendo determinar a concentración de agregación crítica (cac) mediante DLS. En medio básico obtívose a cac a concentracións menores que en medio ácido, comprobando así a súa dependencia co pH.
[en] Interference between two languages is quite frequent in language contact situations. Ireland has been a territory in which different linguistic substrata have coexisted and influenced each other throughout all her history. In the Late Modern English period, as it is nowadays, two languages were spoken in the island, Irish and English. This circumstance caused a linguistic interference in the spoken and written use of English in Ireland. The passive voice will be the grammatical vehicle used in this study to see any possible interference between both Irish and English. Therefore, this circumstance will be analysed using a corpus of texts written by authors of each territory during the eighteenth and nineteenth centuries. These texts belong to two scientific disciplines, Mathematics and History, Which, presumably, will provide us with a broad view of the linguistic phenomenon under analysis. Aspects such as the most frequent type of verbs used in the passive voice, the presence of auxiliaries or modals, or the by-phrase agent will be considered. All these grammatical features will be explored according to the variables of discipline and geographical provenance of writers in order to reach an accurate conclusion about linguistic interference.

[gl] A interferencia entre dúas linguas é bastante frecuente en situacións de contacto lingüístico. Irlanda é un territorio no que diferentes substratos lingüísticos existiron e se influíron mutuamente ao longo de toda a súa historia. Na época do inglés moderno tardío, igual que hoxe en día, falábanse dúas linguas na illa, irlandés e inglés. Esta circunstancia provocou unha interferencia lingüística no uso do inglés falado e escrito en Irlanda. A voz pasiva será a estrutura gramatical usada neste estudo para detectar calquera posible interferencia entre o irlandés e o inglés. Polo tanto, esta circunstancia será analizada usando un corpus de textos escritos por autores de cada territorio durante os séculos XVIII e XIX, o que, presumiblemente, nos dará unha ampla visión do fenómeno lingüístico a analizar. Entre os aspectos a considerar encóntranse o tipo de verbos usados con maior frecuencia na voz pasiva, a presenza de verbos auxiliares ou modais, ou o uso do axente pasivo expresado a través "by-phrase". Todas estas características gramaticais exploraranse tendo en conta as variables de disciplina e orixe xeográfica dos escritores para chegar a unha conclusión precisa sobre a interferencia lingüística.
[en] Over the last decades there has been a notable rise of what was initially called Gender Studies. This dissertation fits into this perspective to study in depth its own genealogy, or the origins of this approach, through a new reading of the intellectual work of nineteenth-century writer Concepción Arenal. Her main arguments are identified and assessed in the context of the history of sociology and as a precursor of the sociology of gender in Spain. Stratification in the context of the nineteenth-century is sociologically considered. Arenal's description of the sex/gender system is reexamined to highlight the sociological factors behind women´s situation, as well as behind the situation of men and children by social class. Education, work and criminology are the major themes through which a deep understanding of the century's patriarchal society is reached through her work, showing that Concepción Arenal is one of the great sociologists of gender of the nineteenth-century to be rescued from "invisible sociology".

[gl] Nas últimas décadas deuse un notable apoxeo dos en principio denominados "Estudos de Xénero-Gender Studies". A tese insírese neste marco teórico para tentar de profundizar na súa propia xenealoxía, nas oríxes desta formulación, a través dunha nova relectura do labor intelectual dunha autora do século XIX, como é Concepción Arenal. Investíganse e avalíanse as súas achegas no contexto da historia da socioloxía española e como iniciadora da socioloxía de xénero en España. Analízanse sociolóxicamente as características da estratificación social no século XIX. Estúdiase o "sistema sexo xénero" descrito por Arenal e saliéntanse os aspectos sociolóxicos que ela sinalou como causantes nos só da situación das mulleres, senón tamén da dos homes e os cativos nas diferentes clases sociais. Educación traballo e criminoloxía son os grandes temas mediante os que se chega a un coñecemento profundo da sociedade patriarcal deste século, a traves da súa obra e mostrándoa como unha das grandes sociólogas de xénero do século XIX, que debe ser rescatada da socioloxía esquecida.