BSC-LT/ACAData huggingface dataset:
[en] This work is based on the academic debate on the penetration of private capital in the public health sector in the most developed countries. The literature highlights different strategies of penetration of this capital since the mid-twentieth century in parallel to the development of the capitalist system. The analysis provided here -based on new quantitative evidence- has allowed the Galician case to fit into the international debate. In particular, the historical reconstruction of the configuration process of the large private hospital groups that today control the private hospital offer in Galicia reveals two key facts. First, the action strategies of private capital in the Galician health system through mergers, absorptions and signing agreements with the public health system. Second, the penetration of international private capital through large investment funds that see the health sector as a strategic market niche with great business opportunities. The last part of this work offers a reflection on these issues and raises the idea of whether public policies should discourage speculation and withdraw "financial value" in certain areas such as health.

[gl] Este traballo baséase no debate académico sobre a penetración do capital privado no sector sanitario público nos países máis desenvolvidos. A literatura destaca distintas estratexias de penetración deste capital dende mediados do século XX en paralelo ao desenvolvemento do sistema capitalista. A análise que aquí se ofrece -a partir de novas evidencias cuantitativas- permitiu que o caso galego encaixase no debate internacional. En particular, a reconstrución histórica do proceso de configuración dos grandes grupos hospitalarios privados que hoxe controlan a oferta hospitalaria privada en Galicia revela dous datos fundamentais. En primeiro lugar, as estratexias de actuación do capital privado no sistema sanitario galego mediante fusións, absorcións e sinatura de convenios co sistema sanitario público. En segundo lugar, a penetración do capital privado internacional a través de grandes fondos de investimento que ven o sector sanitario como un nicho de mercado estratéxico con grandes oportunidades de negocio. A última parte deste traballo ofrece unha reflexión sobre estas cuestións e suscita a idea de se as políticas públicas deben coartar a especulación e retirar "valor financeiro" en determinadas áreas como a sanidade.
[en] Introduction: asthma is a non-communicable and highly prevalent lung disease associated with a lower capacity for bronchial response that can affect the quality of life based on changes in lung function, musculoskeletal disorders and postural disorders. Methods: three case studies (patients diagnosed with asthma) and controls were performed. The pressure pain threshold was assessed in the tarsal tunnel and the peroneal malleolus (I), the range of ankle dorsiflexion and 1st metaphalangeal joint, the fall rate (II) and health. of the foot using the Foot Health Status Questionnaire and Beck's depression inventory in Spanish (III). Results: patients with asthma showed significant differences in the following parameters: decrease in the pressure pain threshold of the bilateral tarsal tunnel (I), lower range of dorsal flexion movement of the ankle and 1st metaphalangeal joint, higher rate of falls (II) and deterioration of the quality of life related to the health of the foot and footwear (III). Conclusions: Patients diagnosed with asthma showed a bilateral increase in the mechanosensitive of the tarsal tunnel, decreased dorsiflexion of the ankle and foot joints, a higher rate of fall and a negative impact on the quality of life.

[gl] Introducción: a asma é unha enfermidade pulmonar non transmisible e altamente prevalente asociada a unha menor capacidade de resposta bronquial que pode prexudicar a calidade de vida baseándose en cambios da función pulmonar, trastornos músculo-esqueléticos e alteración posturais. Métodos: realizaronse tres estudos de casos (pacientes diagnosticados de asma) e controis. Avaliouse o umbral de dor á presión no tunel tarsal é no maleolo peroneal (I), o rango de dorsiflexión do nocello e da 1ª articulación metarsofalánxica, a taxa de caídas (II) e o estado de sáude dos pés utilizando o Foot Health Status Questionnaire e o Beck depression inventory nas suas versións españolas(III). Resultados: Os pacientes asmáticos amosaron diferenzas significativas nos seguintes parámetros: diminución do limiar de dor á presión do tunel tarsaiano bilateral (I), menor rango de movemento de flexión dorsal do nocello e da 1ª articulación metatarsofalánxica, maior taxa de caídas (II) e un nivel de calidade deteriorado relacionado coa saúde dos pés na dimensión de calzado (III). Conclusións: Os pacientes diagnosticados de asma amosaron un incremento bilateral da mecanosensibilidade no túnel tarso, una diminución da dorsiflexión das articulación do nocello e do pé, unha maior taxa de caidas e un impacto negativo na calidade de vida.
[en] The summary of each chapter of this doctoral thesis is presented below. Chapter I: This section contains a description of the importance of aquaculture in the world and the diseases caused by pathogenic bacteria which produce great economic losses to this industry. Similarly, it shows some ways to treat these diseases and the possibility of using the bacterial iron uptake systems to develop new vaccines and antimicrobials. Finally, some strategies for the heterologous expression of membrane proteins, their purification and their crystallization are presented. Chapter II: We made the cloning, expression and purification of rFrpA, a receptor protein of piscibactin, which is a siderophore from Photobacterium damselae subsp. piscicida. The obtained protein was used in vaccination trials, achieving protection in treated fish. Furthermore, using X-ray crystallography we proposed a tridimensional structure for rFrpA. On the other hand, we prepared advanced synthetic intermediates which allowed us to make progress in the total synthesis of piscibactin. Chapter III: We studied the siderophores produced by Aeromonas salmonicida subsp. salmonicida. Firstly, we isolated, purified, and characterized the amonabactins Amo P 693 and Amo P 750. Secondly, we identified the Fe(III) and Ga(III) complexes of amonabactins Amo T 732, Amo T 789, Amo P 693, and Amo P750, using mass spectrometry. Moreover, we made the cloning, expression and purification of rFstA, receptor protein of siderophores of this bacterium.

[gl] A continuación preséntase o resumo de cada un dos capítulos que fan parte desta tese doutoral. Capítulo I: Nesta sección descríbese a importancia da acuicultura a nivel mundial e as enfermidades causadas polas bacterias patóxenas que producen grandes perdas económicas a esta industria. Do mesmo modo, abórdase o tratamento destas enfermidades e a posibilidade de usar os mecanismos de captación de ferro para desenvolver novas vacinas e antimicrobiáns. Por último, preséntanse as estratexias para a expresión heteróloga de proteínas de membrana, a súa purificación e cristalización. Capítulo II: Realizouse a clonaxe, a expresión e purificación de FrpA, proteína receptora da piscibactina, sideróforo de Photobacterium damselae subsp. piscicida. A proteína obtida utilizouse en ensaios de vacinación lográndose protección nos peixes tratados. Ademáis, mediante cristalografía de Raios X realizouse unha aproximación á estrutura tridimensional de FrpA. Por outra parte, preparáronse intermedios avanzados que permitiron progresar na síntese total da piscibactina. Capítulo III: Estudáronse os sideróforos producidos por Aeromonas salmonicida subsp. salmonicida. En primeiro lugar illáronse, purificáronse e caracterizáronse as amonabactinas Amo P 693 e Amo P 750. Posteriormente, mediante espectrometría de masas, identificáronse os complexos de Fe(III) e Ga(III) das amonabactinas Amo T 732, Amo T 789, Amo P 693 e Amo P 750. Por outra parte, realizouse a clonaxe, a expresión e purificación de FstA, proteína receptora de sideróforos desta bacteria.
[en] This doctoral thesis addresses the analysis of structural incapacities of Criminal Law to act as a limitation to punitive power. On the basis of the verification of such incapacities, it is proposed that it is proportionality, in the sense that it was unleashed by the German constitutional jurisdiction, that it could act effectively as such a containment device for the punitive power of the State. The adoption of proportionality as a statute of limitation of the punitive power requires its adaptation to conceptual grounds of the Criminal Law, giving rise to what is proposed to be called proportional lawfulness. The adoption of proportional lawfulness requires, in any case, acceptance of the premise that the criminal prohibition contains a primary norm or conduct norm that emanates from the offence description by law, as well as a consequence that emanates from the secondary norm that complements the first one, are irrelevant in fundamental rights. By general rule, a forbidden criminal conduct falls within the scope of freedom or other fundamental rights. It is accepted to correct this plan, it can be concluded that, as interference, the criminal prohibition must comply with the standards of proportional lawfulness.

[gl] Esta tese doutoral aborda a análise das incapacidades estruturais da legalidade penal para actuar como limitación á potestade punitiva. Sobre a base da constatación de tales incapacidades, proponse que é a proporcionalidade, no sentido no que foi desenvolta pola xurisdición constitucional alemá, a que podería actuar eficazmente como tal aparello de contención do poder punitivo do Estado. A adopción da proporcionalidade como estatuto de limitación da potestade punitiva require adaptala ás esixencias conceptuais do Dereito Penal, dando lugar ao que se propón denominar juridicidad proporcional. A adopción da juridicidad proporcional require, en todo caso, a aceptación da premisa de que a prohibición penal contida na norma primaria ou de conduta que emana do tipo penal, así como a consecuencia que emana da norma secundaria que complementa á primeira, son inxerencias en dereitos fundamentais. Isto é, que, por regra xeral, a conduta prohibida polo tipo penal atópase dentro do suposto de feito da liberdade ou doutros dereitos fundamentais. Se se acepta a corrección deste orzamento, pódese concluír en que, en tanto inxerencia, a prohibición penal debe cumprir cos estándares da juridicidad proporcional.
[en] Introduction: Social support is a fundamental pillar in the health of older people because it acts by promoting health and modulating behaviors related to it. Methods: It was carried out a cross-sectional study with a sample of 30 people 60 and over attending activities sponsored by the Department of Social Services in the Council of Xove (Lugo). We designed an ad hoc structured questionnaire with questions taken from the National Health Survey of Spain (2011-2012). Bivariate analysis was conducted using the test Chi-square to study the association between some of the qualitative variables which by its relevance to the objectives of the study were selected. Results: No statistically significant association was observed between emotional and personal support and health determinants including psychological morbidity and possible cases of psychiatric disorders, consumption of smoke and alcohol use, physical exercise and be (or not) following a food diet. Conclusions: The current social transformation could imply that the traditionally benefits on health attributed to social support may have less weight than other socio-historic times. Longitudinal studies are needed to analyze the results produced by the social and demographic changes in social support of the elderly and to clarify, among others, the causal reversibility of the social support and health determinants.

[gl] Introdución: O apoio social constitúe un piar fundamental na saúde das persoas maiores xa que actúa promovendo a saúde e modulando os comportamentos relacionados con esta. Material e métodos: Levouse a cabo un estudo transversal cunha mostra de 30 persoas de 60 e máis anos que asistían a actividades promovidas polo Departamento de Servizos Sociais do Concello de Xove (Lugo). Deseñouse un cuestionario ad hoc estruturado con cuestións tomadas da Enquisa Nacional de Saúde de España (2011-2012). Realizouse unha análise bivariante mediante a proba de chi-cadrado para estudar a asociación entre algunhas das variables cualitativas que, pola súa relevancia para os obxectivos do estudo, foron seleccionadas. Resultados: Non se observou ningunha asociación estatisticamente significativa entre o apoio afectivo e persoal e os determinantes de saúde que incluían a morbilidade psicolóxica e posibles casos de trastornos psiquiátricos, o consumo de tabaco e alcohol, a práctica de exercicio físico e estar a seguir ou non unha dieta alimentaria. Conclusións: a actual transformación social podería implicar que os beneficios sobre a saúde tradicionalmente atribuídos ao apoio social poidan ter menos pesos que noutros momentos socio-históricos. Un dos retos no futuro é dispoñer de estudos lonxitudinais que permitan analizar os resultados que producen os cambios sociodemográficos no apoio social das persoas maiores para aclarar, entre outras, a reversibilidade causal do apoio social e os determinantes de saúde.
[en] Introduction: Among the many existing arrhythmias, atrial fibrillation is the most common. The anatomical reconstruction using navigation systems and the use of increasingly sophisticated catheters has increased the number of ablations and decreased the number of complications. Specialized resources needed are made where nursing through their care, plays a key role. Objectives: In order to respond to the need to update a review to be described comprehensively nursing care to a patient undergoing AF ablation in electrophysiology laboratory will be performed. Results: Supplies last decade with issues that have relevance clinical care in relation to the ablation procedure for atrial fibrillation in the laboratory were selected. The search was conducted in the following databases: PubMed, Dialnet, ScienceDirect, Journal Nursing in Cardiology; 7 items that were supplemented with other primary sources. Aspects related to electrophysiology laboratory, ablation techniques and sources, navigation systems, equipment, pain management, procedures and complications were described. Discussion: The increase in the number and complexity of the ablations implies the presence in the laboratories of qualified nursing staff in handling technology.

[gl] Introdución: Entre as arritmias existentes, a fibrilación auricular é o máis frecuente. A reconstrución anatómica utilizando sistemas de navegación e o uso de catéteres cada vez máis sofisticados aumentaron o número de ablacións e diminuíron o número de complicacións. Fanse necesarios recursos especializados onde a enfermaría, cos seus coidados, xoga un papel fundamental. Obxectivos: Para responder á necesidade de actualización realizarase unha revisión que permita describir de maneira global os coidados de enfermaría a un paciente sometido a unha ablación de FA no laboratorio de electrofisioloxía. Desenvolvemento: Seleccionáronse artigos da última década con aspectos que tiveran relevancia clínico-asistencial en relación ao procedemento de ablación da fibrilación auricular no laboratorio. Realizouse a procura nas seguintes bases de datos: PubMed, Dialnet, ScienceDirect, Revista Enfermería en Cardiología; resultaron 7 artigos que se complementaron con outras fontes primarias. Describíronse aspectos relativos ao laboratorio de electrofisioloxía, técnicas e fontes de ablación, sistemas de navegación, material, tratamento da dor, procedementos e complicacións. Discusión: O aumento do número e complexidade das ablacións realizadas implica a presenza nos laboratorios de persoal de enfermaría cualificado no manexo de tecnoloxía avanzada.
[en] Hakai is an E3 ubiquitin-ligase protein that binds to the E-cadherin molecule, leading to its internalization and subsequent degradation. E-cadherin loss is associated with a lower degree of differentiation and increased invasion and metastasis. For this reason, it´s important to highlight the influence of Hakai in cancer: it is a potential molecular target for the treatment of this pathology. The objective of this study is the development in the laboratory of a new technology based on liquid biopsy to analyze the expression of Hakai as an early diagnostic marker of tumor progression. For this, we will carry out the extraction of exosomes from samples from different patients. This is a non-invasive technique, which has multiple advantages in relation to other more routine and frequent practices at present for the detection of cancer and its early diagnosis.

[gl] Hakai é unha proteína E3 ubiquitina-ligasa que se une á molécula E-cadherina, dando lugar á súa interiorización e posterior degradación. A perda de E-cadherina asóciase a un menor grao de diferenciación e a unha maior invasión e metástase. Por este motivo, é importante resaltar a influencia de Hakai no cancro: trátase dunha potencial diana molecular para o tratamento desta patoloxía. O obxectivo deste estudo é o desenvolvemento no laboratorio dunha nova tecnoloxía baseada na biopsia líquida para analizar a expresión de Hakai como marcador diagnóstico precoz da progresión do tumor. Para iso, levaremos a cabo a extracción de exosomas de mostras de diferentes pacientes. Trátase dunha técnica non invasiva, que presenta múltiples vantaxes en relación con outras prácticas máis rutineiras e frecuentes na actualidade para a detección do cancro e o seu diagnóstico precoz.
[en] Introduction: sudden death (SD) caused by ventricular fibrillation (VF) during acute myocardial infarction (AMI) is one of the main causes of death in western countries. VF is a pathology associated with genetic and/or environmental factors. Among the genetic factors, long non-coding RNAs (lncRNA) may play a role in the pathophysiology of VF in AMI. Objectives: (1) to analyze the expression of 10 lncRNA in 24 patients with AMI, of which 12 presented VF, (2) to analyze the expression of 10 lncRNA in 24 patients with AMI, of whom 12 did not present VF, and (3) to compare the expression of these 10 lncRNAs in both groups. Material and methods: a bibliographic search was carried out to select 10 lncRNA related to coronary disease and / or arrhythmias. The analysis of the expression of these 10 lncRNA was performed by the real-time polymerase chain reaction (qPCR). Expression data was analyzed with GraphPad Prism 6 and qBase programs. Results: of the 10 lncRNA analyzed (MIAT, CDKN2B-AS1 or ANRIL, MALAT, NEAT1, KCNQ1OT1, UCA1, LIPCAR, SLC16A1-AS1, TK2-4, TNFRSFM-ASI), it was observed a significantly lower expression of CDKN2B-AS1 or ANRIL and KCNQ1OT1 in patients with VF in AMI vs patients with AMI without VF (P ≤ 0.05). Conclusions: the results obtained show that CDKN2B-AS1 or ANRIL and KCNQ1OT1 lncRNA in patients with VF during AMI may play an important role in the development of this pathology. Therefore, the study of lncRNA and their relationship with VF in AMI should continue.

[gl] Introdución: a morte súbita (MS) orixinada pola fibrilación ventricular (FV) durante o infarto agudo de miocardio (IAM) é unha das principais causas de morte en países occidentais. A FV é unha patoloxía asociada a factores xenéticos e/ou ambientais. Dentro dos factores xenéticos, os ARN longos non codificantes (ARNlnc) poden xogar un papel na fisiopatoloxía da FV no IAM. Obxectivos: (1) analizar a expresión de 10 ARNlnc en 24 doentes con IAM, dos cales 12 presentaron FV, (2) analizar a expresión de 10 ARNlnc en 24 doentes con IAM, dos cales 12 non presentaron FV, e (3) comparar a expresión destes 10 ARNlnc en ambos os grupos. Material e métodos: realizouse unha procura bibliográfica para seleccionar 10 ARNlnc relacionados con enfermidade coronaria e/ou arritmias. A análise de expresión destes 10 ARNlnc realizouse mediante a reacción en cadea da polimerase en tempo real (qPCR). Os datos de expresión analizáronse cos programas GraphPad Prism 6 e qBase. Resultados: dos 10 ARNlnc analizados (MIAT, CDKN2B-AS1 ou ANRIL, MALAT, NEAT1, KCNQ1OT1, UCA1, LIPCAR, SLC16A1-AS1, TK2-4, TNFRSFM-ASI), observouse unha expresión significativamente menor de CDKN2B-AS1 ou ANRIL e KCNQ1OT1 nos doentes con FV no IAM vs doentes con IAM sen FV (P ≤ 0,05). Conclusións: os resultados obtidos mostran que os ARNlnc CDKN2B-AS1 ou ANRIL e KCNQ1OT1 en doentes con FV durante un IAM poden ter un papel importante no desenvolvemento desta patoloxía. Por tanto, débese continuar co estudo dos ARNlnc e a súa relación coa FV no IAM.
[en] Objective: To determine the existence of changes in the structure of gray (GM) and white matter (WM) in individuals with chronic pelvic pain syndrome (CPPS) using Magnetic Resonance Imaging. To examine the association between structural parameters and pain duration and intensity. To investigate the sexual dimorphism associated with structural parameters in CPPS. Materials and methods: A search was conducted in the databases Pubmed, WOS, Scopus, Cinahl, and Academic Search Complete in December 2022. Studies involving adult individuals with CPPS and healthy controls were selected. The MINORS scale was applied to assess the methodological quality. Results: Nineteen studies were included, with 10 analyzing GM, 6 analyzing WM, and 3 analyzing both tissue types. A total of 718 patients with CPPS and 737 controls (83% female and 17% male) were obtained. There was a greater tendency for decreased volume and density GM in regions such as the insula, anterior cingulate cortex, and thalamus. Compared to controls, increased fractional anisotropy and mean diffusivity were predominantly detected in the longitudinal fasciculus and thalamic pathways in CPPS (p<0.05). Conclusion: The ascending and inhibitory pain pathways present contrasting patterns in GM parameters and the reorganization of WM structure in patients with CPPS compared to controls. Future prospective studies are needed to address technical and clinical variability to obtain reliable data.

[gl] Obxectivos: Determinar a existencia de cambios na estrutura da substancia cinzenta (SC) e substancia branca (SB) cerebral en persoas con dor pélvico crónico (DCP) mediante IRM. Examinar a asociación entre os parámetros estruturais e a duración e intensidade da dor. Coñecer o dimorfismo sexual asociado aos parámetros estruturais en DCP. Metodoloxía: Realizouse unha busca nas bases de datos Pubmed, WOS, Scopus, Cinahl e Academic Search Complete en decembro de 2022. Selecionáronse estudos con persoas adultas con DPCP e controis sanos. Aplicouse a escala MINORS para avaliar a calidade metodolóxica. Resultados: Incluíronse 19 estudos, 10 analizaron a SC, 6 a SB e 3 ambas ases dúas tecidos. Obtivéronse 718 pacientes con SDCP e 737 controis (83 % mulleres e 17 % homes). Observouse unha maior tendencia a diminución do volume e densidade da SG en rexións como a ínsula, a corteza cingulada anterior e o talamo. Detectouse maioritariamente un aumento de AF e DM no fascículo longitudinal e vias talámicas en SDCP en comparación cos controis (p<0,05). Conclusións: As vías ascendentes e inibitorias da dor presentan patróns contrapostos nos parámetros da SC e na reorganización da estrutura da SB, en pacientes con DCP en comparación cos controis. Necesítanse futuros estudos prospectivos que aborden a variabilidade técnica e clínica para obter datos confiables e comprender os mecanismos neurobiolóxicos asociados á dor en DCP.