BSC-LT/ACAData huggingface dataset:
[en] Eosinophilic cellulitis is an uncommon, inflammatory and chronic disorder of unknown etiology. Corticosteroids are currently considered as the first-line treatment but they are not without significant disadvantages such as contraindications in steroid-resistant cases and patients with frequent recurrences. We report a patient suffering from Wells' syndrome with a 24-year history of symptomatic and generalized skin lesions. After consultation in our department, treatment with colchicine 1 mg/day was prescribed resulting in large clinical improvement. No side effects have been recorded. To our knowledge, this is an original disease approach. Although small, our clinical experience supports the inclusion of colchicine in the drug armamentarium when treating patients suffering from Wells' syndrome. Indeed, its excellent safety profile makes it very attractive for patients with frequent recurrent episodes who need secure options for the medium- and long-term disease control

[gl] A celulitis eosinofílica é un trastorno infrecuente, inflamatorio e crónico de etioloxía descoñecida. Actualmente, considérase que os corticosteroides son o tratamento de primeira liña, pero non carecen de desvantaxes significativas, como as contraindicacións nos casos resistentes a esteroides e os pacientes con recidivas frecuentes. Divulgamos a un paciente que sofre da síndrome de Wells cunha historia de 24 anos de lesións cutáneas sintomáticas e xeneralizadas. Despois da consulta no noso servizo, prescribiuse tratamento con colchicina 1 mg / día, o que resultou nunha gran melloría clínica. Non se rexistraron efectos secundarios. Ata onde sabemos, este é un enfoque da enfermidade orixinal. Aínda que pequena, a nosa experiencia clínica apoia a inclusión de colchicina no arsenal farmacolóxico cando se trata a pacientes con síndrome de Wells. De feito, o seu excelente perfil de seguridade faio moi atractivo para os pacientes con episodios recorrentes frecuentes que necesitan opcións seguras para o control da enfermidade a mediano e longo prazo
[en] Due to the increase of diagnostic cases of pertussis in our area, in recent years, we decided to carry out a review with the objective of knowing the characteristics clinical-epidemiological aspects of this disease in our medium.

[gl] Debido ao aumento de casos diagnósticos de tosferina na nosa área, nos últimos anos, decidimos realizar unha revisión co obxectivo de coñecer as características clínico-epidemiolóxicas desta enfermidade no noso medio
[en] This article deals with the creation and putting into operation of the "La Gota de Leche" institution in Santiago de Compostela, based on various archival and press primary sources. Although the start of its activity was late compared to other similar cities, its benefits were soon seen, through the decline in infant mortality figures. Structured in a pediatric office that selected children who went to the "La Gota de Leche", prenatal consultation, home delivery assistance and vaccination center, forming, together, the Municipal Institute of Childcare. The assistance work served as the basis for the new care model of 1941, with the promulgation of the Social Security Law that caused the disappearance of these institutions. We approach the profile of the employees of the institution and the controversies and criticisms about the work developed in the Drops of Milk.Key words: La Gota de Leche, Santiago de Compostela, Municipal Institute of Childcare, Breastfeeding Office, breastfeeding, infant mortality.

[gl] Este artigo trata da creación e posta en marcha da institución "La Gota de Leche" en Santiago de Compostela, baseada en diversas fontes primarias de arquivos e prensa. Aínda que o inicio da súa actividade foi tardío en comparación con outras cidades similares, pronto se viron os seus benefi-cios, por mor do descenso das cifras de mortalidade infantil. Estruturado nunha consulta pediátrica que seleccionou aos nenos que foron á "La Gota de Leche", consulta prenatal, asistencia a domici-lio e centro de vacinación, formando xuntos o Instituto Municipal de Puericultura. O traballo de asistencia serviu de base para o novo modelo asistencial de 1941, coa promulgación da Lei da Se-guridade Social que provocou a desaparición destas institucións. Abordamos o perfil dos emprega-dos da institución e as polémicas e críticas sobre o traballo desenvolvido nas "Gota de Leche".Palabras clave: La Gota de Leche, Santiago de Compostela, Instituto Municipal de Coidados Infantís, Oficina de lactancia materna, lactación materna, mortalidade infantil
[en] To study the space-time distribution of suicide in Galicia from 1976 to 1998, taking into account gender, age, season and method of suicide. For each sex crude and age-adjusted rates per province and age-specific rates per period (1978-84, 1985-91, 1992-98) were calculated. To estimate mortality risk and time trends in the municipalities, a Bayesian hierarchical model was used. In the last few years mortality from suicide has increase considerably. Age-adjusted rates of 6 per 105 at the beginning of the study rose to 10 per 105 at the end. The increase was greatest among men. The higher rates were observed in the elderly, although in terms of time trends the highest increase occurred among adolescents and young adults. In both sexes the main method of suicide was hanging. Less common methods were jumping from a height and shooting. The greatest number of suicides took place during the spring and summer months. In terms of spatial distribution, a high number of suicides were committed in the province of Lugo; in the municipalities, mortality risk decreased from North to South and an inverse temporal trend was observed in both sexes. This differed from the space-time patterns of suicides committed using methods other than hanging. Suicide is an important health problem in Galicia not only because to its magnitude but also because of the increasing rates, especially among young people. Geographical and temporal analysis can identify priority areas where preventive policies should be implemented.

[gl] Estudar a distribución espazo-temporal do suicidio en Galicia de 1976 a 1998, tendo en conta o sexo, a idade, a estacionalidade e o método de suicidio. Para cada sexo, calculáronse as taxas brutas e axustadas por idade por provincia e as taxas específicas por idade por período (1978-84, 1985-91, 1992-98). Para estimar o risco de mortalidade e as tendencias de tempo nos municipios, utilizouse un modelo xerárquico bayesiano. Nos últimos anos, a mortalidade por suicidio aumentou considerablemente. As taxas axustadas por idade de 6 por 105 ao comezo do estudo aumentaron a 10 por 105 ao final. O aumento foi maior entre os homes. As taxas máis altas observáronse nos anciáns, aínda que en termos de tendencias de tempo o maior aumento produciuse entre os adolescentes e adultos novos. En ambos os sexos, o principal método de suicidio era aforcarse. Os métodos menos comúns foron saltar desde unha altura e disparar. O maior número de suicidios tivo lugar durante os meses de primavera e verán. En termos de distribución espacial, cometeuse un alto número de suicidios na provincia de Lugo; nos municipios, o risco de mortalidade diminuíu de norte a sur e observouse unha tendencia temporal inversa en ambos os sexos. Isto diferiu dos patróns de suicidio no espazo e o tempo cometidos con métodos distintos de colgarse. O suicidio é un problema de saúde importante en Galicia, non só pola súa magnitude senón tamén polas taxas cada vez maiores, especialmente entre os mozos. A análise xeográfica e temporal pode identificar áreas prioritarias onde as políticas preventivas deben ser implementadas
[en] To determine the feasibility of mRNAs (C-MYC, BCL-XL, BCL-6, NF-κβ, PTEN and AKT) in exosomes of plasma as a liquid biopsy method for monitoring and prognostic evolution in B-cell lymphomas. Exosomes were isolated from 98 patients with B-cell Lymphoma and 68 healthy controls. mRNAs were analyzed by quantitative PCR. An additional 31 post-treatment samples were also studied. In the general and follicular lymphoma series, the presence of AKT mRNA was associated with poor response to rituximab-based treatment. Patients with first relapse or disease progression showed a lower percentage of PTEN and BCL-XL mRNA. The presence of BCL-6 mRNA was associated with a high death rate. The absence of PTEN mRNA in the general series, and presence of C-MYC mRNA in follicular lymphomas, were associated with short progression-free survival. BCL-6 and C-MYC mRNA were independent prognostic variables of overall survival. C-MYC mRNA may provide prognostic information with respect to overall survival. BCL-XL mRNA and increase of BCL-6 mRNA in post-treatment samples could serve as molecular monitoring markers. This is the first large study to evaluate the prognostic and predictive values of pretreatment tumor-associated mRNA in exosomes. BCL-6 and C-MYC mRNA positivity in pretreatment samples were predictors of worse PFS compared to patients with mRNA negativity. C-MYC mRNA positivity was also a statistically significant predictor of inability to obtain complete response with first-line therapy.

[gl] Determinar a viabilidade de los ARNm ( C- MYC, BCL- XL, BCL-6, NF-κβ, PTEN y AKT) en exosomas de plasma como un método de biopsia líquida para a monitorización e evolución pronóstica en linfomas de células B. Os exosomas aisláronse de 98 pacientes con linfoma de células B e 68 controis sanos. Os ARNm analizaronse mediante PCR cuantitativa. Tamén se estudaron 31 muestras adicionais despois do tratamento. Na serie de linfoma xeral e olicular, a presencia de ARNm de AKT asociouse cunha resposta deficiente ao tratamento baseado en rituximab. Os pacientes coa primera recaída a progresión da enfermidade mostraron un menor porcentaxe de ARNm de PTEN y BCL- XL. A presencia de ARNm de BCL-6 asociouse con unha alta tasa de mortalidade. A ausencia de ARNm de PTEN na serie xeral e a presencia de ARNm de C- MYC en linfomas foliculares asociaronse coa supervivencia libre de progresión tala. BCL-6 y C- MYC mRNA foron variables pronósticas independentes da supervivencia global. O ARNm de C- MYC pode proporcionar información pronóstica con respecto da supervivencia global. O ARNm de BCL- XL e o aumento do ARNm de BCL-6 nas mostras posteriores ao tratamiento poderían servir como marcadores de monitorización molecular. Este é o primer gran estudio para evaluar os valores pronósticos e predictivos do ARNm asociado ao tumor pretratamento en exosomas. BCL-6 y C- MYC mRNA positivas en muestras de pretratamento foron predictores de peor PFS en comparación cos pacientes con ARNm negatividad. A positividade do mRNA de C- MYC tamen foi un predictor estadísticamente significativo da incapacidade de obter unha respuesta completa coa terapia de primeira línea.
[en] The Iowa Infant Feeding Attitude Scale (IIFAS) has been shown to have good psychometric properties for English-speaking populations, but it has not been validated among low-risk pregnant women in Spain. The aim of this study was to assess the reliability and validity of the translated version of the IIFAS in order to examine infant feeding attitudes in Spanish women with an uncomplicated pregnancy. Low-risk expectant women (n = 297) were recruited from eight primary public health care centres in Galicia (Spain). Questionnaires including both socio-demographic and breastfeeding characteristics and items about infant feeding were administered during the third trimester. Participants were contacted by telephone during the postpartum period to obtain information regarding their infant feeding status. Prediction validity and internal consistency were assessed. The translated IIFAS (69.76 ± 7.75), which had good psychometric properties (Cronbach's alpha = 0.785; area under the curve (AUC) of the receiver operating characteristic (ROC) curve = 0.841, CI95% = 0.735⁻0.948), showed more positive attitudes towards breastfeeding than towards formula feeding, especially among mothers who intended to exclusively breastfeed. This scale was also useful for inferring the intent to breastfeed and duration of breastfeeding. This study provides evidence that the IIFAS is a reliable and valid tool for assessing infant feeding attitudes in Spanish women with an uncomplicated pregnancy.

[gl] Demostrouse que a escala de actitude de alimentación infantil de Iowa ( IIFAS) ten boas propiedades psicométricas para as poboacións de fala inglesa, pero non se validou entre as mulleres embarazadas de baixo risco en España. O obxectivo deste estudo foi avaliar a fiabilidade e validez da versión traducida do IIFAS para examinar as actitudes de alimentación infantil en mulleres españolas cun embarazo sen complicacións. As mulleres embarazadas de baixo risco ( n = 297) foron recrutadas en oito centros de atención primaria de saúde en Galicia (España). Durante o terceiro trimestre administráronse cuestionarios que incluían características sociodemográficas e de amamantamento e artigos sobre a alimentación infantil. Chamouse por teléfono ás participantes durante o período de posparto para obter información sobre a alimentación infantil. Avaliáronse a validez da predición e a consistencia interna. O IIFAS traducido (69,76 ± 7,75), que tiña boas propiedades psicométricas (área alfa de Cronbach = 0,785; área baixa a curva ( AUC) da curva característica operativa do receptor ( ROC) = 0,841, IC95% = 0,735-0,948),mostráronse máis actitudes positivas cara á lactación materna que cara á alimentación con fórmula, especialmente entre as nais que tiñan a intención exclusiva de aleitar. Esta escala tamén foi útil para inferir a intención de aleitar e a duración da lactación materna. Este estudo proporciona a evidencia de que o IIFAS é unha ferramenta fiable e válida para avaliar as actitudes de alimentación infantil en mulleres españolas cun embarazo sen complicacións.
[en] The objective of this report is to assess the clinical utility of radiofrequency ablation or cyanoacrylate sealing in the treatment of varicose veins. According to published evidence, both techniques appear to be safe and reduce the symptoms associated with this pathology in a majority of treated patients, who are satisfied with the results.

[gl] O obxetivo do informe consistiu en valorar a utilidade clínica da ablación mediante radiofrecuencia ou o selado mediante cianocrilato no tratamento das varices. Segundo a evidencia publicada, ambas técnicas parecen ser seguras e reducen a sintomatoloxía asociada a esta patoloxía, cunha maioría dos pacientes tratados manisfestándose satisfeitos cos resultados obtidos. ​
[en] Since 2011, the World Health Organization (WHO) has made great strides in approaching and developing methods for estimating the true burden of childhood tuberculosis (TB) and obtaining the recognition it deserves. Approximately one million children develop TB every year and at least 14% die. 51.4% are under 5 years old (< 5 y.). The first global estimates published for 2014 of resistance to isoniazid (H) and multiresistance were 12.1% and 3.2% respectively, while the tuberculosis infection was estimated at 67 million children, five of which due to strains resistant to H and two by multiresistant strains. Every infected or sick child represents a sentinel event of recent transmission of Mycobacterium tuberculosis (M. tuberculosis) in the community and should therefore be a priority in TB prevention and control strategies. The objective of this thesis is to make a descriptive study of the evolution of childhood TB in Galicia from the implementation of the Galician Program of Prevention and Control of TB (PGPCTB) in 1996 to 2011 and its epidemiological characteristics, based on data obtained from the TB Information System Galicia (SITUB). Despite a favorable evolution, it represents 6.5% of the burden of TB, with a higher incidence than the European and Spanish average.

[gl] Desde 2011, a Organización Mundial da Saúde (OMS) avanzou enormemente no enfoque e desenvolvemento de métodos para estimar a carga real da tuberculosis (TB) infantil, e obter o recoñecemento que se merece. Aproximadamente un millón de nenos desenvolven TB cada ano e polo menos o 14% morren. O 51,4% son menores de 5 anos (<5 anos). As primeiras estimaciòns globais publicadas para o ano 2014 de resistencia a isoniazida (H) e multirresistencia foron dun 12,1% e 3,2% respectivamente, mentres que a infección tuberculosa estimouse en 67 millóns de nenos, cinco dos cales por cepas resistentes a H e dous por cepas multirresistentes. Todo neno infectado ou enfermo representa un evento centinela de transmisión recente de Mycobacterium tuberculosis (M. tuberculosis) na comunidade, polo que deben ser unha prioridade nas estratexias de prevención e control de TB. O obxectivo desta tese é facer un estudo descriptivo da evolución de TB infantil en Galicia desde a implantación do Programa Galego de Prevención e Control da TB (PGPCTB) en 1996 ata o 2011 e as súas características epidemiológicas, a partir dos datos obtidos do Sistema de información de TB (SITUB) de Galicia. Malia unha evolución favorable, representa un 6,5% da carga de TB, cunha incidencia máis elevada que a media europea e española.
[en] This practical and simple guide will guide in the diagnosis and treatment of patients with thrombosis and cancer. It aims to reduce variability in management in the Autonomous Community of Galicia and reduce the negative impact that thrombosis has on cancer patients.

[gl] Esta guía práctica e sinxela, guiará no diagnóstico e tratamento dos pacientes con trombose e cancro. Pretende reducir a variabilidade no manexo na Comunidade Autónoma de Galicia, e reducir o impacto negativo que a trombose presenta nos pacientes con cancro.
[en] Many aspects of biological diversity and their life mechanisms remain unknown and understudied. With the advent of the genomic era, RNA sequencing (RNA-seq) has become one of the most powerful tools to unravel the secrets of biological adaptation and diversity in all species through their particular gene expression profiles. Here, we studied comparatively the genes expressed in different tissues of several species of one of the least known group of vertebrates, the caecilians (order Gymnophiona). Caecilians are fossorial, limbless, tropical amphibians that constitute the sister group of frogs and salamanders. Little is known about this enigmatic animal group. To improve the understanding of caecilian ecology and evolution, we have analysed caecilian genomic functional elements at three levels: across other vertebrates, across caecilian species and among caecilian tissue types. Our study provides valuable insights about the expansion of gene machineries in vertebrates, points out proteincoding genes involved in the specific evolutionary adaptations of caecilian amphibians, and highlights important functional elements in the caecilian skin tissue type. To our knowledge, this is the first large-scale genomic characterization of the genetic functional elements of this secretive vertebrate group, and it provides the basis for future research on the molecular elements underlying the remarkable biology of caecilian amphibians.

[gl] Denantes os incribeis avances en prol da comprensión da vida, a biodiversidade segue a agochar enchentes misterios. O florecemento de tecnoloxías de secuenciación masivas e ferramentas bioinformáticas asociadas abren unha cantidade inimaxinable de diferentes abordaxes de estudo en todas as disciplinas científicas da Bioloxía. Unha delas é o uso da secuenciación do ARN que a través da análise da expresión xénica ten a potencialidade de revelar as bases moleculares do funcionamento e adaptacións das especies. Nesta tese de doutoramento exploramos os patróns de expresión xénica de tecidos distintos de varias especies dun dos grupos animais máis descoñecido, as cecilias (orden Gymnophiona). Xunto a ras, sapos, limpafontes e píntegas, as cecilias forman a clase de tetrápodos Amphibia. As cecilias son anfibios, ápodos, vermiformes, fosoriais que atópanse exclusivamente nos trópicos. Co obxectivo de ampliar o coñecemento ecolóxico e evolutivo neste misterioso grupo, levamos a cabo análises comparativas a tres niveis: entre vertebrados, entre as especies de cecilias de estudo e entre os seus tecidos. Os nosos traballos amosan unha expansión do número de familias xénicas en vertebrados, sinalan innovacións moleculares vinculadas aos diferentes fitos na evolución das cecilias e identifican xenes con importantes funcións na pel destes anfibios. Esta tese conforma a primeira caracterización xenómica das cecilias e presenta as bases moleculares para futuras investigacións, expandindo o coñecemento sobre vertebrados e especificamente sobre as cecilias.
[en] With the objective to update the knowledge of the human Pleistocene occupations in Madrid basin, in 2003 a group of multidisciplinary investigation started a discretionary and selective follow-up of the fronts of gravel and sand quarries of the open exploitations in the low sections of the Manzanares and Jarama rivers. The developed work has provided the localization of deposits with industry, fauna and/or register pollinic that go from the MIS 9/11 to the MIS 3, between those who stand out the excavation in extensión of three Pleistocene beds, and the realization of soundings with lithic industry and/or fauna in diverse points. Also they have dated deposits and grounds of the Tardiglacial (MIS 2) and of the Holoceno (MIS 1), for which at present disposes of to him a good chronological closeness of the terraces of the Manzanares valley and of the litostratigraphic units of the Arganda complex terrace of the Jarama river, as well as the fauna and industry become a partner of the same thing.

[gl] Co obxectivo de actualizar o coñecemento das ocupacións humanas pleistocenas na Cunca de Madrid, en 2003 un grupo de investigación pluridisciplinar iniciou un seguimento discrecional e selectivo das frontes de graveiras e areeiros das explotacións abertas nos tramos baixos dos ríos Manzanares e Jarama. O traballo desenvolvido proporcionou a localización de xacementos con industria, fauna e/ou rexistro polínico que van dende o MIS 9/11 ao MIS 3, entre os que destacan a escavación en extensión de tres xacementos pleistocenos, e a realización de sondaxes con industria lítica e/ou fauna en diversos puntos. Tamén se dataron depósitos e chans do Tardiglacial (MIS 2) e do Holoceno (MIS 1), polo que actualmente se dispón dunha boa aproximación cronolóxica das terrazas do val do Manzanares e das unidades litoestratigráficas da Terraza Complexa de Arganda do río Jarama, así como da fauna e industria asociada a estas.
[en] The aim of this paper is to analyze the recent European Court of Human Rights case-law on sexual diversity which it offers legal tools to States to adapt their legislation and judicial and administrative practices to prevent, investigate and punish, if convenient, the growing homophobia that challenges values such as democracy, justice, freedom, tolerance and spirit of openness that underpin the Council of Europe

[gl] O obxectivo deste traballo consiste na análise da recente xurisprudencia do Tribunal Europeo de Dereitos Humanos en materia de diversidade sexual que lles ofrece ferramentas xurídicas aos Estados para adaptar as súas lexislacións e as prácticas xudiciais e administrativas para previr, investigar e castigar, se procede, a crecente homofobia que desafía valores como o de democracia, xustiza, liberdade, tolerancia e espírito de apertura que fundamentan o Consello de Europa