BSC-LT/ACAData huggingface dataset:
[en] The Hallux Limitus, is a pathology in which the base of the proximal phalanx of the hallux is subluxated in plantarflexion on the head of the first metatarsal, so, the first metatarsophalangeal joint is unable to perform the full range of extension. It has also been defined as an alteration that occurs with the limitation of the metatarsophalangeal extension of less than 20° without plantarflexion of the first metatarsal. Its prevalence increases with age, it occurs in approximately 46% of women and 32% of men at 60 years of age. In the literature consulted, there are only a few studies on orthopodology treatments for this topic, so this research is interesting for us. In this study we will select two groups of 64 patients in each group, and treat them with plantar orthoses, one group will be treated with added support under the first metatarsophalangeal joint and another with a cut-out in the first metatarsophalangeal joint. The main objective is to determine which type of plantar orthoses is most effective for the treatment of Hallux Limitus

[gl] O Hallux Limitus, é unha patoloxía na cal a base da falanxe proximal do hallux está subluxada plantarmente sobre a cabeza do primeiro metatarsiano, polo que, a primeira articulación metatarsofalánxica é incapaz de realizar todo o rango de extensión. Tamén se definiu como unha alteración que cursa con limitación da extensión metatarsofalánxica de menos de 20° sen plantarflexión do primeiro metatarsiano. A súa prevalencia aumenta coa idade, estariamos a falar aproximadamente do 46% das mulleres e do 32% dos homes aos 60 anos de idade. Na bibliografía consultada atopamos poucos estudos sobre tratamentos ortpodológicos para o devandito tema polo que a súa investigación parécenos interesante. Neste estudo seleccionaremos dous grupos de 64 pacientes cada un, e tratarémolos con soportes plantares, un grupo será tratado con alongo da primeira articulación metatarsofalanxica e outro con cut- out na primeira articulación metatarsofalanxica. O obxectivo principal é determinar que tipo de ortesis plantares ten maior eficacia para o tratamento do Hallux Limitus.
[en] In this Final Grade Project, it was studied the synthesis of biphasic calcium phosphate (formed by hydroxyapatite and β-tricalcium phosphate) by a wet method. Additionally, it was synthesized mesoporous silicon dioxide and barium titanate to be added, separately, to the biphasic calcium phosphate, with the purpose of varying the properties of the bioceramic material for favour its osteoinducion capacity and the integration of the biomaterial in the biologic medium. The characterization of the synthesized materials was carried out by the techniques of: Fourier-transform infrared spectroscopy (FTIR), powder X-Ray diffraction (XRD), optical microscopy, scanning electron microscopy (SEM), transmission electron spectroscopy (TEM) and thermogravimetric analysis (TGA). As a result, BCP, mesoporous SiO2, nanoparticles of BaTiO3 and the composite materials of BCP-SiO2 and BCP-BaTiO3 were synthesized with the suitable composition, structure and morphology, so it's expected that they would be suitable to be incorporated in the biological tissue and to favour the bone regeneration

[gl] Neste Traballo de Fin de Grao estudouse a síntese por vía húmida de fosfato cálcico bifásico (formado por hidroxiapatita e β-fosfato tricálcico). Leváronse a cabo tamén as sínteses de óxido de sílice mesoporoso e de nanopartículas de titanato de bario para a súa posterior adición, por separado, ao fosfato cálcico bifásico, coa fin de variar as propiedades do material biocerámico de cara a favorecer a capacidade de osteoinducción e a integración do biomaterial no medio biolóxico. A caracterización dos materiais sintetizados fíxose mediante as técnicas de: espectrometría infravermella por transformada de Fourier (FTIR), difracción de raios X de po (DRX), microscopía óptica, microscopía electrónica de varrido (SEM), microscopía electrónica de transmisión (TEM) e análise termogravimétrica (TGA). Como resultado, sintetizouse o BCP coa composición, estrutura e morfoloxías desexadas, así como o SiO2 mesoporoso, as nanopartículas de BaTiO3 e os compostos de BCP-SiO2 e BCP-BaTiO3, tamén coa composición, estrutura e morfoloxías desexadas, polo que se espera que sexan aptos para poder incorporarse ao tecido biolóxico e favorecer a rexeneración ósea.
[en] This doctoral thesis is an observational study in patients with ST-segment elevation myocardial infarction (STEMI) in our geographical area treated with coronary intervention. The presence, prevalence, and variety of bacteria in thrombi have never been studied in Galician patients. The objective was to detect bacterial deoxyribonucleic acid (DNA) in thrombotic material from patients with STEMI. We included 109 consecutive patients in whom coronary thrombus was obtained by thromboaspiration, and one peripheral blood sample. The presence of bacterial DNA was analysed by probe-based real-time Polymerase Chain Reaction (PCR). The presence of: Aggregatibacter actinomycetemcomitans, Chlamydia pneumoniae, viridans group streptococci, Porphyromonas gingivalis, Fusobacterium nucleatum, Tannarella forsythia, Treponema denticola, Helycobacter pylori, Mycoplasma pneumoniae, Staphylococus aureus, Prevotella intermedia, and Streptococcus mutans was studied. Bacterial DNA from 4 species was detected in 9,2% of the patients studied: viridans group streptococci, (5.5%), followed by Staphylococcus aureus (1.8%); Porphyromonas gingivalis and Prevotella intermedia (0.9% respectively). No bacterial DNA was detected in peripheral blood. In conclusion, DNA from 4 bacterial species is present in thrombi from a small proportion of STEMI patients. Bacteria could be latently present in plaques and might play a role in plaque instability and thrombus formation leading to STEMI in these patients.

[gl] Esta tese doutoral é un estudo observacional realizado en doentes con infarto agudo de miocardio con elevación do segmento ST (IAMCEST), tratados mediante intervencionismo coronario percutáneo, co obxectivo de analizar a presenza e tipo de bacterias, mediante a detección de Ácido Desoxirribonucleico (ADN) nos trombos aspirados das arterias coronarias. Non se estudou a presenza, prevalencia e variedade de organismos bacterianos en pacientes galegos. Incluíronse 109 doentes consecutivos nos que se obtivo material trombótico e mostra de sangue periférica; analizouse a presenza do ADN bacteriano coa Reacción en Cadena de la Polimerasa (PCR) en tempo real de: Aggregatibacter actinomycetemcomitans, Chlamydia pneumoniae, viridans group streptococci, Porphyromonas gingivalis, Fusobacterium nucleatum, Tannarella forsythia, Treponema denticola, Helycobacter pylori, Mycoplasma pneumoniae, Staphylococus aureus, Prevotella intermedia, e Streptococcus mutans. Detectouse ADN bacteriano de 4 especies no 9,2% dos doentes: viridans group streptococci, (6 doentes, 5,5%), Staphylococus aureus (2 doentes, 1,8%); Porphyromonas gingivalis e Prevotella intermedia (0,9% respectivamente). Non se atopou ADN bacteriano na sangue periférica nestes doentes. En conclusión, hai ADN de 4 especies bacterianas nos trombos dunha pequena proporción de pacientes con IAMCEST. Estas bacterias poderían ter un rol na inestabilidade da placa e na formación do trombo que conduce ó IAMCEST nestes pacientes.
[en] The aquaculture industry is being severely affected by the emergence and spread of infectious diseases in fish and the high resistance of bacteria that cause them to current antibiotics. Therefore, there is a need to deepen the study of these infectious diseases in order to develop new and more effective drugs. In this work, the synthesis of a fluorescent probe (siderophore-fluorophore conjugate) was proposed for the subsequent study of its internalization within the bacterium and the monitoring of forunculosis caused by Aeromonas salmonicida subsp. salmonicida. The siderophore selected as an input vector in the bacterium is an analog of the amonabactins, which are involved in the uptake of Fe(III) by the pathogenic bacterium A. salmonicida and the fluorophore is sulforodamine B. The spacer used to connect the siderophore and the fluorophore was PEG2, different from the one used in previous studies. This work allowed to obtain a conjugate between the suitably protected siderophore and fluorophore, the sulforhodamine B, which was characterized by both NMR and mass spectrometry. The elimination of the protecting groups of the obtained conjugate will allow obtaining the desired fluorescent probe.

[gl] A industria acuícola está sendo enormemente afectada pola aparición e propagación de enfermidades infecciosas nos peixes e a elevada resistencia das bacterias que as provocan aos antibióticos actuais. Por tanto, surxe a necesidade de profundizar no estudo desas enfermidades infecciosas co fin de desenvolver novos fármacos máis efectivos. Neste traballo propúxose a síntese dunha sonda fluorescente (conxugado sideróforo-fluoróforo) para o posterior estudo da súa internalización dentro da bacteria e a monitorización da forunculosis provocada por Aeromonas salmonicida subsp. salmonicida. O sideróforo seleccionado como vector de entrada na bacteria é un análogo de amonabactinas responsable da captación de Fe(III) da bacteria patóxena A. salmonicida, sendo o fluoróforo a sulforodamina B. O espaciador utilizado para conectar o sideróforo e o fluoróforo foi PEG2, distinto ao empregado en estudos previos. O traballo realizado permitiu a obtención dun conxugado entre o sideróforo convenientemente protexido e o fluoróforo, a sulfordamina B, que foi caracterizado tanto por RMN coma por espectrometría de masas. A eliminación dos grupos protectores do conxugado obtido permitirá obter a sonda fluorescente desexada.
[en] Cancer represents one of the main causes of death worldwide, and its impact continues to grow year after year. Out of every kind of cancer, breast cancer is the most common one in women, affecting one in four females having no other risk factors beyond age and gender. At the molecular level, breast cancer is a heterogeneous disease, with five different subtypes distinguished. Each one of them has different levels of aggressiveness and tolerance to the multiple available treatments. Therefore, being able to classify a clinical case as early as possible can have a significant influence on the disease's development. The most widely used classification methods use bulk RNA-sequencing (RNA-seq) to perform the classification. This type of data shows the average gene expression of every cell in the biological sample in question. The aim of this project is to analyze the behavior of these methods when applied to single-cell RNA-sequencing (scRNA-seq) data. This more modern higher resolution type of data, individually collects the gene expression of each cell present in the biological tissue. Furthermore, a benchmark will be conducted with different state-of-the-art Machine Learning (ML) models to compare their performance in this classification task.

[gl] O cancro representa unha das principais causas de morte globalmente e a súa afectación continúa crecendo ano tras ano. Dentro de todos os seus tipos, o cancro de mama é o tipo de cancro máis habitual en mulleres, afectando a unha de cada catro, e sen que haxa factores de risco máis aló de idade e xénero. A nivel molecular, o cancro de mama é unha enfermidade heteroxénea, diferenciándose cinco subtipos distintos. Cada un deles ten distintos niveles de agresividade e tolerancia aos múltiples tratamentos dispoñibles. Polo tanto, seren capaces de clasificar un caso clínico o antes posible pode ter gran repercusión no desenvolvemento da enfermidade. Os metodos clasificatorios máis utilizados empregan datos bulk RNA-sequencing (RNA-seq) para poder realizar a clasificación. Este tipo de datos mostran a expresión xénica promedio de todas as células da mostra biolóxica que se está a analizar. O obxectivo deste proxecto é comprobar o comportamento destes métodos ao aplicárense a datos single-cell RNA-sequencing (scRNA-seq). Este tipo de datos máis moderno recolle a expresión xénica de cada célula presente no texido biolóxico. Ademais, levarase a cabo un benchmark con distintos modelos de Machine Learning (ML) de estado do arte para comparar o seu rendemento nesta tarefa de clasificación.
[en] INTRODUCTION - Historically, the application of physical means for healing injuries and illnesses is knowledge that has been understood by the humanity from prehistoric times. During its course, there were different professionals that made use of these means, until arriving to today's figure of the physiotherapist. In Galicia, at the present time, the knowledge about Physiotherapy and the presence of physiotherapists is different according to if we talk about rural or urban environment. Thus, rural Galicia has its own characteristics, both in relation to the population and to health knowledge and practices. OBJECTIVE – The objective of this study will be to determine the degree of knowledge about Physiotherapy presented by the inhabitants of the Galician rural world, as well as knowing both their experience with the world of physiotherapy and the relationship they have with the traditional knowledge that is the precursor of physiotherapy. MATERIAL AND METHODS – This work presents a historical-descriptive study on the knowledge of Physiotherapy in a rural Galician geographical area. On this study, the participants, through a survey, will answer a set of questions that will try to establish what is the current knowledge about the world of Physiotherapy.

[gl] INTRODUCIÓN – Historicamente, a aplicación de medios físicos para a curación de lesións e enfermidades é un saber que se estende na humanidade dende a época prehistórica. Durante o seu transcurso, foron diferentes profesionais os que fixeron uso destes medios, ata chegar hoxe en día á figura do fisioterapeuta. En Galicia, e no momento presente, o coñecemento sobre a Fisioterapia e a presencia do fisioterapeuta difire segundo se fale de medio urbano ou medio rural. Así, a Galicia rural presenta uns trazos identitarios, tanto no relativo á poboación como aos saberes e prácticas sanitarias. OBXECTIVO - O obxectivo do estudo será determinar cal é o coñecemento acerca da Fisioterapia que presentan os habitantes do mundo rural galego, así como coñecer tanto a súa experiencia co mundo da Fisioterapia como a relación que manteñen cos saberes tradicionais precursores da mesma. MATERIAL E MÉTODOS – Exporase un estudo histórico-descritivo sobre o coñecemento da Fisioterapia nunha zona xeográfica rural galega, onde os seus participantes, a través dunha enquisa, responderán unha serie de preguntas que tratarán de establecer cal é o seu coñecemento actual acerca do mundo da Fisioterapia.
[en] Within the following project, a study of the structural behaviour of several beam-colum welded joints with different stiffeners in the central area of the column will be developed. This essay will be implemented by finite elements method with the commercial program ABAQUS. For this purpose, different models of solids will be realized in order to obtain the moment-rotation curves of the joints. Subsequently, the results obtained from the model of solids will be compared with two models of beams, one of them in which the joint will be totally rigid and in the other the joint will have a rotational spring. These models support the development of the experimental tests that will be carried out in the Structural Analysis Laboratory, LAE, of Universidade da Coruña.

[gl] No presente proxecto realizarase un estudo do comportamiento estructural de diversas unións soldadas viga-pilar con distintos rixidizadores na zona central do pilar. Este estudo levarase a cabo mediante o método de elementos finitos co programa comercial ABAQUS. Para iso realizaranse distintos modelos de sólidos dos que se obterán curvas momento-rotación das unións. Posteriormente compararanse os resultados obtidos a partir do modelo de sólidos con dous modelos de vigas, nun deles a unión será totalmente ríxida e noutro a unión será un muelle rotacional. Estes modelos apoian o desenvolvemento dos ensaios experimentales que vanse a realizar no Laboratiorio de Análese Estructural, LAE, da Universidade da Coruña.
[en] Background: The properties of the honey such as antimicrobial, antiinflammatory, antioxidant and its involvement in wound healing make it a promising medical product. Aims: Reviewing the actual evidence about honey treatment and its advantages. Method: After a research in Pubmed was done, the selection criteria were applied and a critic evaluation was done, fourteen articles have been chosen to their further analysis. Results: 7 systematic reviews, 6 experimental studies and 1 case series were analyzed. Discussion: Taking into account the scarcely solid evidence of medical honey effectiveness in different kind of wounds, new well-designed and reproducible studies are required. Conclusions: Its use is safe, although conclusive evidence of its benefit was only found in burns treatment.

[gl] Introdución: As propiedades antibacterianas, antiinflamatorias, antioxidantes da mel e a súa participación na cicatrización das feridas, fana un produto con un gran potencial medicinal. Obxectivos: Revisar a evidencia existente sobre o tratamento de feridas con mel e a súa vantaxe. Metodoloxía: Trala busca en Pubmed, a aplicación de criterios de selección e a valoración crítica; catorce artigos foron seleccionados para a súa análise. Resultados: Estudáronse 7 revisións sistemáticas, 6 estudios experimentais e unha serie de casos. Discusión: Ante a escasa evidencia sólida da efectividade da mel medicinal nos distintos tipos de feridas, novos estudos ben deseñados e reproducibles fanse necesarios. Conclusións: A súa utilización é segura, aínda que só se atopa evidencia concluínte do seu beneficio no tratamento de queimaduras.
[en] Crime in Compostela was published in 1984 by Carlos G. Reigosa, considered the inaugural work of the criminal novel in Galician. Despite the relative editorial success of the genre, few women writers will cultivate it: the first, Laura Caveiro, author of Polas inmensas e alleas fortunas (1995). This paper reviews the later contributions of Galician women writers to criminal narrative –Matei un home (2003) de An Alfaya, Sete caveiras (2014) de Elena Gallego, O faro escuro (2015) de María López Sández e Compostela Noire (2016) de Blanca Riestra–, to place them in relation to the clichés of the genre and with the definition of archetypes of female (and male) characters.

[gl] En 1984 foi publicada Crime en Compostela, de Carlos G. Reigosa, considerada a obra inaugural da novela criminal en galego. A pesar do relativo éxito editorial do xénero, poucas escritoras o frecuentarán: a primeira, Laura Caveiro, autora de Polas inmensas e alleas fortunas (1995). Neste traballo revísanse as achegas posteriores das escritoras galegas á narrativa criminal –Matei un home (2003) de An Alfaya, Sete caveiras (2014) de Elena Gallego, O faro escuro (2015) de María López Sández e Compostela Noire (2016) de Blanca Riestra–, para as situar en relación cos clixés do xénero e coa definición de arquetipos de personaxes femeninos (e masculinos).
[en] Background: The family is a key element in the recovery process in people with severe mental illness, still providing useful information for the recovery of the person and providing support and continuity throughout the process. Given the importance of social support, it is necessary to know the perception that people with mental health problems have about their family support and influence of it on their occupational performance, to improve the process of intervention from occupational therapy, because the occupational therapists work with individuals and communities to improve their ability to engage in the occupations that they want, need, or are expected to do, or by modifying the occupation or the environment to get better support their occupational commitment . Objectives: The main objective of this study is to explore the perception that people with serious mental health problems about their family support and influence in their occupational performance. Methodology: The methodology used is qualitative type from a phenome- nological paradigm. Informants will be people with mental health dysfunc- tion and professionals belonging to an association located in the province of A Coruña. The data collection will be made by an individual semi- structured interview.

[gl] Introducción: A familia é un elemento clave no proceso de recuperación en persoas con enfermidade mental grave, sendo proveedora de información útil para a recuperación da persoa e prestando apoio e continuidade ao longo de todo o proceso. Dada a importancia do apoio social, é necesario coñecer a percepción das persoas con problemas de saúde mental do seu apoio familiar e a influenza del no seu desmpeño ocupacional, para mellorar o proceso de intervención da terapia ocuapcional, posto que os terapeutas ocupacionais traballan cos individuos e as comunidades para mellorar a súa capacidade de se involucrar en ocupacións que eles queren, teñen, ou se espera que fagan, ou modificando ocupacións ou o ambiente para apoiar o seu compromiso ocupacional. Obxectivos: O obxectivo deste estudo é explorar a percepción que as persoas con graves problemas de saúde mental teñen do seu apoio familiar e a influenza sobre seu desempeño ocupacional. Metodoloxía: A metodoloxía utilizada é do tipo cualitativa dende un paradigma fenomenolóxico. Os informantes serán persoas con disfunción na saúde mental e profesionais pertencentes a unha asociación situada na provincia de A Coruña. A obtención de datos farase mediante unha entrevista semiestruturada individual.
[en] The development of high stresses and distortions is one of the main concerns in laser surface heat treatments. The objective of the present thesis is to contribute to the better understanding of the thermomechanical behavior during laser transformation hardening and laser metal deposition techniques, including as well the development of a exible tool with customizable models for the numerical calculation of the thermomechanical variables, and the microstructural evolution through phase transformation models. Such a tool will be useful for the prediction of the residual strains and stresses after the processes as well as the phase changes, helping with its optimization and understanding, thus reducing the number of test trials necessary to achieve the desired results. Something that has paramount importance when unique or expensive workpieces should be treated. The model was validated using several experimental techniques to assess its predictions and ne tune some of its parameters.

[gl] A xeración de altas tensións e deformacións é unha das maiores preocupacións dos tratamentos térmicos super ciais por láser. O obxectivo da presente tesis é o de contribuir ao mellor entendemento do comportamento termomecánico durante o endurecemento super cial por láser e as técnicas de deposición de metal por láser, incluindo tamén o desenvolvemento dunha ferramenta exible con modelos adaptables para o cálculo numérico das variables termomecánicas, así como da evolución microestrutural mediante modelos de transformación de fase. Tal ferramenta será de utilidade na predicción dos esforzos e deformacións residuais despois do tratamento, axudando coa sua optimización e mellorando o seu entendemento, e por tanto diminuindo o número de ensaios necesarios para obter os resultados desexados. Algo de meirande importancia cando pezas únicas ou de gran custo deben ser tratadas. O modelo foi validado mediante o uso de varias técnicas experimentais para comparar o grao de axeitamento das súas prediccións e axustar algúns dos seus parámetros.