[en] Strawberries are an important fruit in the Mediterranean diet because of their high content of essential nutrients and beneficial phytochemicals, which seem to exert beneficial effects in human health. Healthy volunteers were supplemented daily with 500 g of strawberries for 1 month. Plasma lipid profile, circulating and cellular markers of antioxidant status, oxidative stress and platelet function were evaluated at baseline, after 30 days of strawberry consumption and 15 days after the end of the study. A high concentration of vitamin C and anthocyanins was found in the fruits. Strawberry consumption beneficially influenced the lipid profile by significantly reducing total cholesterol, low-density lipoprotein cholesterol and triglycerides levels (?8.78%, ?13.72% and ?20.80%, respectively; P<.05) compared with baseline period, while high-density lipoprotein cholesterol remained unchanged. Strawberry supplementation also significant decreased serum malondialdehyde, urinary 8-OHdG and isoprostanes levels (?31.40%, ?29.67%, ?27.90%, respectively; P<.05). All the parameters returned to baseline values after the washout period. A significant increase in plasma total antioxidant capacity measured by both ferric reducing ability of plasma and oxygen radical absorbance capacity assays and vitamin C levels (+24.97%, +41.18%, +41.36%, respectively; P<.05) was observed after strawberry consumption. Moreover, the spontaneous and oxidative hemolysis were significant reduced (?31.7% and ?39.03%, respectively; P<.05), compared to the baseline point, which remained stable after the washout period. Finally, strawberry intake significant decrease (P<.05) the number of activated platelets, compared to both baseline and washout values. Strawberries consumption improves plasma lipids profile, biomarkers of antioxidant status, antihemolytic defenses and platelet function in healthy subjects, encouraging further evaluation on a population with higher cardiovascular disease risk.

[es] Las fresas son una fruta importante en la dieta mediterr?nea debido a su alto contenido de nutrientes esenciales y fitoqu?micos beneficiosos , que parecen ejercer efectos beneficiosos en la salud humana. Voluntarios sanos fueron suplementados diariamente con 500 g de fresas durante 1 mes. El perfil lip?dico plasm?tico , los marcadores circulantes y celulares del estado antioxidante, el estr?s oxidativo y la funci?n plaquetaria se evaluaron al inicio, despu?s de 30 d?as de consumo de fresas y 15 d?as despu?s del final del estudio. Se encontr? una alta concentraci?n de vitamina C y antocianinas en las frutas. El consumo de fresas influy? beneficiosamente en el perfil lip?dico al reducir significativamente los niveles de colesterol total, colesterol de lipoprote?nas de baja densidad y triglic?ridos (?8,78%, ?13,72% y ?20,80%, respectivamente; P < ,05) en comparaci?n con el per?odo inicial, mientras que el colesterol de lipoprote?nas de alta densidad se mantuvo sin cambios. La suplementaci?n con fresas tambi?n disminuy? significativamente los niveles s?ricos de malondialdeh?do , 8-OHdG urinario e isoprostanos (?31,40%, ?29,67%, ?27,90%, respectivamente; P < ,05). Todos los par?metros volvieron a los valores basales despu?s del per?odo de lavado. Se observ? un aumento significativo en la capacidad antioxidante total del plasma medida tanto por la capacidad reductora f?rrica del plasma como por los ensayos de capacidad de absorci?n de radicales de ox?geno y los niveles de vitamina C (+ 24,97%, + 41,18%, + 41,36%, respectivamente; P < ,05) despu?s del consumo de fresas. Adem?s, la hem?lisis espont?nea y oxidativa se redujeron significativamente (?31,7% y ?39,03%, respectivamente;P< ,05), en comparaci?n con el punto basal, que permaneci? estable despu?s del per?odo de lavado. Finalmente, la ingesta de fresas disminuy? significativamente (P< ,05) el n?mero de plaquetas activadas, en comparaci?n con los valores basales y de lavado. El consumo de fresas mejora el perfil lip?dico plasm?tico, los biomarcadores del estado antioxidante, las defensas antihemol?ticas y la funci?n plaquetaria en sujetos sanos, lo que fomenta una mayor evaluaci?n en una poblaci?n con mayor riesgo de enfermedad cardiovascular.