[en] Objectives: To determine epidemiological and clinical characteristics of different subtypes of cutaneous lupus erythematosus (CLE) in the Sanitary Area of A Coruña (SAC). To analyze the prevalence and factors associated with the presence of systemic lupus erythematosus (SLE), activity and damage of skin disease, metabolic syndrome (MS), cardiovascular risk factors (CVR), and health-related quality of life (HRQoL). Methods: Descriptive cross-sectional prevalence study of 260 patients with CLE in the SAC, April 2013-August 2016. The EUSCLE Core Set Questionnaire was used to characterize the patients and the illness. Tobacco consumption (packs/year), Fagerström test, alcohol consumption (g/ day), MS (ATP III, 2001), CVR and the quality of life index in dermatology (DLQI) were determinate in all patients. Results: The most prevalent CLE subsets were discoid LE (DLE) (36.5%) and intermittent (ICLE)/tumidus (LET) (28.5%). 82.7% had only CLE and 17.3% SLE criteria. Patients with CLE without SLE had one decade later onset of the disease and a lower W:M ratio vs SLE (W:M ratio 2:1 vs 8:1). SLE was associated with antinuclear (ANA) > 1/160 (OR: 10.58) and anti-RNP (OR: 32.84) antibodies, whereas the body mass index (BMI) was found to be protective (OR: 0.76). A high activity was related to chronic CLE (CCLE) (OR: 1.98), to be active smoker (OR: 3.04; B: 2.05) and high C-reactive protein (CRP) levels (B: 2.56); while damage was related to activity (B: 0.14). The MS had a lower prevalence in SLE patients than in those having only CLE (22.7% vs. 34.7%) and was associated with BMI (OR: 1.43) and lupus anticoagulant (LA) (OR: 9.78). High CVR was associated with disease duration (OR: 1.40), age (OR: 1.49) and active smoking (OR: 147.18), while female sex resulted a protective factor (OR: 0.10). HRQoL was more affected in women (OR: 3.17) and in patients with elevated disease activity (OR: 1.21) and high nicotine dependence (OR: 10.30). Conclusions: The most prevalent CLE subtypes were DLE and LET. The W:M ratio was lower and the disease onset was later in CLE patients without SLE criteria. The presence of SLE in CLE patients was associated with ANA and anti-RNP positive antibodies, and inversely to the BMI. The cutaneous activity of the LE was related to the CCLE subtype, the active smoking and the increase of the CRP, while the damage was only related to the activity. MS was associated with BMI and LA. RCV was positively associated with duration of LE, age and active smoking, while female sex was protective. HRQoL was more affected in women and in patients with a higher cutaneous activity and high nicotine dependence.

[gl] Obxectivos: Determinar as características epidemiolóxicas e clínicas dos subtipos de lupus eritematoso cutáneo (LEC) no Área de Saúde da Coruña (ASC). Analizar a prevalencia e factores asociados ca presenza de lupus eritematoso sistémico (LES), a actividade e as secuelas, o síndrome metabólico (SM), o risco cardiovascular (RCV) e a calidade de vida relacionada coa saúde (CVRS) Materiais e Métodos: Un estudo transversal descriptivo de prevalencia en 260 doentes con LEC do ASC, abril/2013-agosto/2016. Utilizouse o EUSCLE Core Set Questionnaire para caracterizar os doentes e a enfermidade; determinouse tabaco consumido (paquetes/ano), test de Fagerström, consumo de alcohol (g/día), síndrome metabólico (SM) (ATP III, 2001), risco cardiovascular (RCV) e índice de calidade de vida en dermatoloxía (DLQI). Resultados: Os subtipos máis prevalentes de LEC foron o discoide (LED) (36,5%) e o intermitente (LECI)/túmido (LET) (28,5%). 82,7% presentaron só lesións cutáneas, e o 17,3%, ademáis, presentaron criterios de LES. Os pacientes con LEC sen LES tiveron a idade ao diagnóstico unha década máis tardía e unha relación M:H máis baixa que os LES (relación M:H 2:1 vs 8:1). A presenza de LES estivo asociada cos anticorpos antinucleares (AAN) > 1/160) (OR: 10,58) e cos anticorpos anti-RNP (OR: 32,84), mentres que o índice de masa corporal (IMC) resultou protector (OR: 0,76). Unha actividade maior relacionouse co LEC crónico (LECC) (OR: 1,98), ser fumador activo (OR: 3,04; B: 2,05), e coa proteína C reactiva alta (PCR) (B: 2,05); mentres que as secuelas (CLASI secuelas) só coa actividade (B: 0,14). O SM foi menos prevalente nos LES, que nos LEC só (22,7% vs. 34,7%). Asociouse con IMC (OR: 1,43) e anticoagulante lúpico (AL) (OR: 9,78). O RCV alto asociouse coa duración da enfermidade (OR: 1,40), a idade (OR: 1,49) e ser fumador activo (OR: 147,18), mentres que ser muller resultou protector (OR: 0,10). A CVRS resultou afectar máis as mulleres (OR: 3,17) e os doentes con maior actividade cutánea da enfermidade (OR: 1,21) e cunha dependencia alta á nicotina (OR: 10,30). Conclusións: Os subtipos máis prevalentes foron o LED e o LET. A relación M:H foi máis baixa e a idade ao diagnóstico de LE máis tardía cando só había LEC. A presenza de LES asociouse cos AAN e anticorpos anti-RNP positivos, e inversamente co IMC. A actividade cutánea relacionouse co LECC, hábito tabáquico e PCR alto; mentres que as secuelas coa actividade. O SM asociouse co IMC e o AL; namentres que o RCV o estuvo coa duración do LE, a idade e o ser fumador activo; ser muller resultou protector. A CVRS afectouse máis nas mulleres, en doentes con maior actividade cutánea e con dependencia alta á nicotina.