[en] Prenylflavonoids are hybrids of terpenoids and flavonoids. Due to the presence of both moeities in their framework, they exhibit interesting biological activities such as antiparasitic, anticarcinogenic, anti-inflammatory Lately, their activity as inhibitors of aromatase and their application on multidrug resistence (MDR) studies increase their importance. Due to their wide activity profile, alkylation of flavones and flavonols with monoterpenes, such as geranyl and diterpenes of labdane moiety, has been carried out. A wide variety of hybrids has been synthesised and antitumour activity research work done. It can be concluded that flavonoids prenylated at C-8 increased their activity.In order to carry out a structure-activity relationship (SAR) study of easier synthesised compounds, 23 alkylated acetophenones have been obtained. It can be concluded that the length of the chain is critical for the activity. Moreover, the C-alkylated are the most active compounds.A straightforward synthesis of two natural C-geranylflavonoids: macarangin and its enatiomer, isomacarangin, has been described. The enantiomer of the natural product isolated from Macaranga denticulata, (+)-denticulaflavonol, has been synthesised for the first time, confirming its structure and determining its absolute configuration.Finally, the synthetic pathway to achieve the synthesis of the cyclohexyl chalcone derivative (CCD) panduratin A has been established. Panduratin A has important biological activities such as anti-inflammatory, anticancer and antivirus. studies increase their importance. Due to their wide activity profile, alkylation of flavones and flavonols with monoterpenes, such as geranyl and diterpenes of labdane moiety, has been carried out. A wide variety of hybrids has been synthesised and antitumour activity research work done. It can be concluded that flavonoids prenylated at C-8 increased their activity.In order to carry out a structure-activity relationship (SAR) study of easier synthesised compounds, 23 alkylated acetophenones have been obtained. It can be concluded that the length of the chain is critical for the activity. Moreover, the C-alkylated are the most active compounds.A straightforward synthesis of two natural C-geranylflavonoids: macarangin and its enatiomer, isomacarangin, has been described. The enantiomer of the natural product isolated from Macaranga denticulata, (+)-denticulaflavonol, has been synthesised for the first time, confirming its structure and determining its absolute configuration.Finally, the synthetic pathway to achieve the synthesis of the cyclohexyl chalcone derivative (CCD) panduratin A has been established. Panduratin A has important biological activities such as anti-inflammatory, anticancer and antivirus.

[es] Los prenilflavonoides son compuestos h?bridos de terpenoides y flavonoides que, al combinar ambos fragmentos en su estructura, presentan interesantes actividades biol?gicas como antiparasitarios, anticarcinog?nicos, antiinflamatorios... y, ?ltimamente est?n tomando mucha importancia su actividad como inhibidores de aromatasa y su aplicaci?n en la resistencia a multif?rmacos. Debido a su interesante perfil de actividad, se ha puesto a punto la alquilaci?n de flavonas y flavonoles con monoterpenos, como geranilo, y diterpenos de esqueleto labdano, obteniendo una gran variedad de h?bridos con los que se ha realizado un estudio de su actividad antitumoral. De dicho estudio se concluye que los flavonoides con cadenas pren?licas en C-8 incrementan su actividad, no siendo activas las bases libres.Con objeto de llevar a cabo un estudio de las relaciones estructura-actividad de mol?culas m?s simples, se han sintetizado veintitr?s derivados de floroacetofenona alquilados con cadenas de diferente longitud, algunas isopr?nicas y otras simplemente lineales con o sin dobles enlaces. Se concluye que la longitud de la cadena es cr?tica para la actividad, siendo m?s activos los productos de C-alquilaci?n en el anillo arom?tico.Se han sintetizado por primera vez dos productos naturales: macarangin e isomacarangin. Tambi?n se ha llevado a cabo la primera s?ntesis de (+)-denticulaflavonol, enanti?mero del producto natural aislado de Macaranga denticulata, confirm?ndose as? su estructura y determinando su configuraci?n absoluta.Finalmente se ha abierto el camino hacia la s?ntesis de la ciclohexil chalcona panduratin A, la cual presenta importantes actividades biol?gicas como antiinflamatorio, anticancer?geno y antiv?rico.