[en] Introduction Study on the influence of sutureless aortic valvular bioprosthesis on the postoperative inflammatory response and on the clinical impact following the implementation of a minimally invasive surgery program (MIS) using sutureless bioprosthesis. Methods Preliminary phase: Randomized clinical trial. Group P (sutureless bioprosthesis through CMI, n = 20), Group C (conventional bioprosthesis through MIS, n = 20). Determination of biomarkers of inflammatory response were obtained. Sutureless-MIS program assessment: Restrospective study. Group A: Sutureless bioprosthesis through MIS (n = 108). Group B: Conventional bioprosthesis through full sternotomy (n = 115). Results Preliminary phase: Randomized clinical trial. Group P (sutureless bioprosthesis through CMI, n = 20), Group C (conventional bioprosthesis through MIS, n = 20). Determination of biomarkers of inflammatory response were obtained. Sutureless-MIS program assessment: Restrospective study. Group A: Sutureless bioprosthesis through MIS (n = 108). Group B: Conventional bioprosthesis through full sternotomy (n = 115). Results Preliminary phase: Reduction of surgical times in Group P versus group C, associated with lower postoperative levels of IL-6 (p = 0.021). Sutureless-MIS program assessment: Perioperative mortality was 1/223 patients, belonging to group B. Surgical times, ICU and hospital stays, transfusional requirements and postoperative aortic valve gradients were lower in group A (p < 0.05). Group A showed a higher rate of pacemaker implantation (p = 0.051). Conclusion The MIS using sutureless aortic bioprosthesis allowed a significant reduction in surgical times associated with lower levels of IL-6 and was shown as a safe and effective technique, providing clinical benefits when compared to conventional surgery.

[gl] Introducción Estudio sobre a influencia das biopróteses valvulares aórticas sen sutura na resposta inflamatoria postoperatoria e sobre o impacto clínico tras a implementación dun programa de cirurxía mínimamente invasiva (CMI) con biopróteses sen sutura. Métodos Fase preliminar: Estudo aleatorizado. Grupo P (Bioprótese sen sutura mediante CMI, n = 20), Grupo C (Bioprótese convencional mediante CMI, n = 20). Realizouse determinación de marcadores de resposta inflamatoria. Avaliación do programa CMI-sen sutura: Estudo restrospectivo. Grupo A: Bioprótese sen sutura mediante CMI (n = 108). Grupo B: Bioprótese convencional mediante esternotomía completa (n = 115). Resultados Fase preliminar: Reducción dos tempos quirúrxicos no grupo P fronte ó grupo C, asociada a menores niveis postoperatorios de IL-6 (p = 0.021). Avaliación do programa CMI-sen sutura: A mortalidade perioperatoria foi de 1/223 pacientes, pertencente ó grupo B. Os tempos quirúrxicos, estancias na UCI e hospitalaria, requirimentos transfusionais e gradientes valvulares aórticos postoperatorios foron menores no grupo A (p < 0.05). O grupo A presentou maior tasa de implante de marcapasos (p = 0.051). Conclusión A CMI con biopróteses aórticas sen sutura permitiu unha reducción significativa dos tempos quirúrxicos asociada a unha disminución dos niveis de IL-6 e mostrouse como una técnica segura e efectiva, engadindo beneficios clínicos respecto da cirurxía convencional.