APPENDIX AI      ADMINISTRATIVE INSTRUCTIONS UNDER THE PCT
---SECTION---A. INSTRUCTIONS RELATING TO GENERAL MATTERS

(as in force from July 1, 1998)
---SECTION---101 Abbreviated Expressions and Interpretation

In these Administrative Instructions:

"Treaty" means the Patent Cooperation Treaty;

"Regulations" means the Regulations under the Treaty;

"Article" means an Article of the Treaty;

"Rule" means a Rule of the Regulations;

"International Bureau" means the International Bureau as defined in
Article 2(xix) of the Treaty;

"International Authorities" means the receiving Offices, the
International Searching Authorities, the International Preliminary
Examining Authorities, and the International Bureau;

"Annex" means an Annex to these Administrative Instructions, unless the
contrary clearly follows from the wording or the nature of the
provision, or the context in which the word is used;

"Form" means a Form contained in Annex A;

[FIGURE]

"WIPO Standard" means a Standard established by the World Intellectual
Property Organization;

"Director General" means the Director General as defined in Article
2(xx) of the Treaty.

The Annexes are part of these Administrative Instructions.

---SECTION---102 Use of the Forms

Subject to paragraphs (b) to (i) and Sections 103 and 114, the
International Authorities shall use, or require the use of, the
mandatory Forms specified below:

Forms for use by the applicant:

PCT/RO/101 (request Form)

PCT/IPEA/401 (demand Form)

Forms for use by the receiving Offices:

PCT/RO/103

PCT/RO/115

PCT/RO/147

PCT/RO/104

PCT/RO/116

PCT/RO/150

PCT/RO/105

PCT/RO/117

PCT/RO/151

PCT/RO/106

PCT/RO/118

PCT/RO/152

PCT/RO/107

PCT/RO/123

PCT/RO/153

PCT/RO/109

PCT/RO/126

PCT/RO/154

PCT/RO/110

PCT/RO/133

PCT/RO/155

PCT/RO/111

PCT/RO/136

PCT/RO/112

PCT/RO/139

PCT/RO/113

PCT/RO/143

Forms for use by the International Searching Authorities:

PCT/ISA/201

PCT/ISA/212

PCT/ISA/233

PCT/ISA/202

PCT/ISA/217

PCT/ISA/234

PCT/ISA/203

PCT/ISA/218

PCT/ISA/235

PCT/ISA/205

PCT/ISA/219

PCT/ISA/236

PCT/ISA/206

PCT/ISA/220

PCT/ISA/209

PCT/ISA/225

PCT/ISA/210

PCT/ISA/228

Forms for use by the International Bureau:

PCT/IB/301

PCT/IB/323

PCT/IB/350

PCT/IB/302

PCT/IB/324

PCT/IB/351

PCT/IB/304

PCT/IB/325

PCT/IB/352

PCT/IB/305

PCT/IB/329

PCT/IB/353

PCT/IB/306

PCT/IB/331

PCT/IB/354

PCT/IB/307

PCT/IB/332

PCT/IB/355

PCT/IB/308

PCT/IB/333

PCT/IB/356

PCT/IB/310

PCT/IB/334

PCT/IB/357

PCT/IB/313

PCT/IB/335

PCT/IB/358

PCT/IB/314

PCT/IB/336

PCT/IB/359

PCT/IB/315

PCT/IB/337

PCT/IB/360

PCT/IB/316

PCT/IB/338

PCT/IB/361

PCT/IB/317

PCT/IB/339

PCT/IB/366

PCT/IB/318

PCT/IB/344

PCT/IB/367

PCT/IB/319

PCT/IB/345

PCT/IB/368

PCT/IB/320

PCT/IB/346

PCT/IB/369

PCT/IB/321

PCT/IB/349

Forms for use by the International Preliminary Examining Authorities:

PCT/IPEA/402

PCT/IPEA/414

PCT/IPEA/437

PCT/IPEA/404

PCT/IPEA/415

PCT/IPEA/439

PCT/IPEA/405

PCT/IPEA/416

PCT/IPEA/440

PCT/IPEA/407

PCT/IPEA/420

PCT/IPEA/441

PCT/IPEA/408

PCT/IPEA/425

PCT/IPEA/442

PCT/IPEA/409

PCT/IPEA/431

PCT/IPEA/443

PCT/IPEA/412

PCT/IPEA/436

PCT/IPEA/444

Slight variations in layout necessary in view of the printing of the
Forms referred to in paragraph (a) in various languages are permitted.

Slight variations in layout in the Forms referred to in paragraph
(a)(ii) to (v) are permitted to the extent necessary to meet the
particular office requirements of the International Authorities, in
particular in view of the production of the Forms by computer or of the
use of window envelopes.

Where the receiving Office, the International Searching Authority and/or
the International Preliminary Examining Authority are each part of the
same Office, the obligation to use the Forms referred to in paragraph
(a) does not extend to communications within that same Office.

The annexes to Forms PCT/RO/106, PCT/RO/118, PCT/ISA/201, PCT/ISA/205,
PCT/ISA/206, PCT/ISA/210, PCT/ISA/219, PCT/IB/313, PCT/IB/336,
PCT/IPEA/404, PCT/IPEA/405 and PCT/IPEA/415 may be omitted in cases
where they are not used.

The notes attached to Forms PCT/RO/101 (request Form) and PCT/IPEA/401
(demand Form) shall be distributed by the International Authorities
concerned together with the printed versions of those Forms. The notes
attached to Form PCT/ISA/220 shall accompany the Form when sent to the
applicant.

The use of Forms other than those referred to in paragraph (a) is
optional.

Where the request or the demand is presented as a computer print-out,
such print-out shall be prepared as follows:

the layout and contents of the request and the demand when presented as
computer print-outs shall correspond to the format of Forms PCT/RO/101
(request Form) and PCT/IPEA/401 (demand Form) ("the printed Forms"),
with the same information being presented on the corresponding pages;

all boxes shall be drawn by solid lines; double lines may be presented
as single lines;

the box numbers and box titles shall be included even where no
information is supplied therein;

the boxes for use by the International Authorities shall be at least as
large as those on the printed Forms;

all other boxes shall be within one cm in size of those on the printed
Forms;

all text shall be 9 points or larger in size;

titles and other information shall be clearly distinguished;

explanatory notes presented in italics on the printed Forms may be
omitted.

Other formats permitted for the presentation of the request and the
demand as computer print-outs may be determined by the Director General.
Any such format shall be published in the Gazette.

---SECTION---103 Languages of the Forms Used by International
Authorities

The language of the Forms used by any receiving Office shall be the same
as the language in which the international application is filed,
provided that:

where the international application is to be published in the language
of a translation required under Rule 12.3(a), the receiving Office shall
use the Forms in such language;

the receiving Office may, in its communications to the applicant, use
the Forms in any other language being one of its official languages.

Subject to Section 104(b), the language or languages of the Forms to be
used by any International Searching Authority shall be specified in the
applicable agreement referred to in Article 16(3)(b).

Subject to Section 104(b), the language or languages of the Forms to be
used by any International Preliminary Examining Authority shall be
specified in the applicable agreement referred to in Article 32(3).

The language of any Form used by the International Bureau shall be
English where the language of the international application is English,
and it shall be French where the language of the international
application is French. Where the language of the international
application is neither English nor French, the language of any Form used
by the International Bureau in its communications to any other
International Authority shall be English or French according to the
wishes of such Authority, and in its communications to the applicant it
shall be English or French according to the wishes of the applicant.

---SECTION---104 Language of Correspondence in Cases Not Covered by Rule
92.2

The language of any letter from the applicant to the receiving Office
shall be the same as the language of the international application to
which such letter relates, provided that, where the international
application is to be published in the language of a translation required
under Rule 12.3(a), any letter shall be in such language. However, the
receiving Office may expressly authorize the use of any other language.

The language of any letter to the International Bureau shall be English
where the language of the international application is English, and it
shall be French where the language of the international application is
French. Where the language of the international application is neither
English nor French, the language of any letter to the International
Bureau shall be English or French, provided that any copy, sent to the
International Bureau as a notification addressed to it, of a Form sent
to the applicant by the receiving Office, the International Searching
Authority or the International Preliminary Examining Authority, does not
require translation into English or French.

---SECTION---105 Identification of International Application with Two or
More Applicants

Where any international application indicates two or more applicants, it
shall be sufficient, for the purpose of identifying that application, to
indicate, in any Form or correspondence relating to such application,
the name of the applicant first named in the request. The provisions of
the first sentence of this Section do not apply to the demand or to a
notice effecting later elections.

---SECTION---106 Change of Common Representative

Where a change is recorded under Rule 92 bis.1(a) in the person of an
applicant who was considered to be the common representative under Rule
90.2(b), the new applicant shall be considered to be the common
representative under Rule 90.2(b) if he is entitled according to Rule
19.1 to file an international application with the receiving Office.

---SECTION---107 Identification of International Authorities and of
Designated and Elected Offices

Whenever the nature of any communication from or to the applicant, from
or to any International Authority or, before national processing or
examination has started, from or to any designated or elected Office so
permits, any International Authority or any designated or elected Office
may be indicated in the communication by the two-letter code referred to
in Section 115.

The indication of a receiving Office, an International Searching
Authority, an International Preliminary Examining Authority or a
designated or elected Office shall be preceded by the letters "RO,"
"ISA", "IPEA," "DO," or "EO," respectively, followed by a slant (e.g.,
"RO/JP," "ISA/US", "IPEA/SE," "DO/EP," "EO/AU").

---SECTION---108 Correspondence Intended for the Applicant

For the purpose of this Section, where there are two or more agents
whose appointments are in force, "first mentioned agent" means the agent
first mentioned in the document containing the appointments or, where
the appointments are contained in two or more documents, in that which
was filed first.

Where a sole applicant has appointed an agent or agents under Rule
90.1(a), correspondence intended for the applicant from the
International Authorities shall, subject to paragraph (d), be addressed
to the agent or, where applicable, to the first mentioned agent.

Where there are two or more applicants, correspondence intended for the
applicants from the International Authorities shall, subject to
paragraph (d), be addressed:

if no common agent has been appointed under Rule 90.1-to the common
representative or, where applicable, to his agent or first mentioned
agent; or

if the applicants have appointed a common agent or common agents under
Rule 90.1(a)-to that common agent or, where applicable, to the first
mentioned common agent.

Where an agent has or agents have been appointed under Rule 90.1(b), (c)
or (d)(ii), paragraphs (b) and (c) shall apply to correspondence
intended for the applicant relating to the procedure before the
International Searching Authority or the International Preliminary
Examining Authority, as the case may be, as if those paragraphs referred
to the agent or agents so appointed.

---SECTION---109 File Reference

Where any document submitted by the applicant contains an indication of
a file reference, that reference shall not exceed 12 characters in
length and may be composed of either letters of the Latin alphabet or
Arabic numerals, or both.

Correspondence from International Authorities intended for the applicant
shall indicate any such file reference.

---SECTION---110 Dates

Any date in the international application, or used in any correspondence
emanating from International Authorities relating to the international
application, shall be indicated by the Arabic number of the day, by the
name of the month, and by the Arabic number of the year. The receiving
Office, where the applicant has not done so, or the International
Bureau, where the applicant has not done so and the receiving Office
fails to do so, shall, after, above, or below any date indicated by the
applicant in the request, repeat the date, in parenthesis, by indicating
it by two-digit Arabic numerals each for the number of the day, for the
number of the month and for the last two numbers of the year, in that
order and with a period, slant, or hyphen after the digit pairs of the
day and of the month (for example, "05 March 1992 (05.03.92)", "05 March
1992 (05/03/92)", or "05 March 1992 (05-03-92)" ).

---SECTION---111 [Deleted]

---SECTION---112 Ceasing of Effect under Articles 24(1)(iii) and 39(2),
Review under Article 25(2) and Maintaining of Effect under Articles
24(2) and 39(3)

Each national Office shall, in its capacity as designated Office, notify
the International Bureau once a year of:

the number of international applications in respect of which, during the
preceding calendar year, the time limit applicable under Article 22 has
expired;

the number of international applications in respect of which, during the
preceding calendar year, the requirements provided for in Article 22
have not been complied with before the expiration of the time limit
applicable under that Article, with the consequence that the effects of
the international applications concerned have ceased under Article
24(1)(iii).

Each national Office shall, in its capacity as elected Office, notify
the International Bureau once a year of:

the number of international applications in respect of which, during the
preceding calendar year, the time limit applicable under Article 39(1)
has expired;

the number of international applications in respect of which, during the
preceding calendar year, the requirements provided for in Article 39(1)
have not been complied with before the expiration of the time limit
applicable under that Article, with the consequence that the effects of
the international applications concerned have ceased under Article
39(3).

Where, under Article 25(2), the designated Office decides that the
refusal, declaration, or finding referred to in Article 25(1) was not
justified, it shall promptly notify the International Bureau that it
will treat the international application as if the error or omission
referred to in Article 25(2) had not occurred. The notification shall
preferably contain the reasons for the decision of the designated
Office.

Where, under Article 24(2) or under Article 39(3), the designated or
elected Office maintains the effect provided for in Article 11(3), it
shall promptly notify the International Bureau accordingly. The
notification shall preferably contain the reasons for the decision of
the designated or elected Office.

---SECTION---113 Special Fees Payable to the International Bureau

The special publication fee provided for in Rule 48.4 shall be 200 Swiss
francs.

The special fee provided for in Rule 91.1(f) shall be payable to the
International Bureau and shall be 50 Swiss francs plus 12 Swiss francs
for each sheet in excess of one. Where that fee has not been paid before
the time of the completion of the technical preparations for
international publication, the request for rectification shall not be
published. Where the last sentence of Rule 91.1(f) applies and the said
fee has not been paid before the time of the communication of the
international application under Article 20, a copy of the request for
rectification shall not be included in that communication.

The special fee provided for in Rule 26 bis.2(c) shall be payable to the
International Bureau and shall be 50 Swiss francs plus 12 Swiss francs
for each sheet in excess of one. Where that fee has not been paid before
the time of the completion of the technical preparations for
international publication, the information concerning the priority claim
which was considered not to have been made shall not be published. Where
the last sentence of Rule 26 bis.2(c) applies and the said fee has not
been paid before the time of the communication of the international
application under Article 20, a copy of the information concerning the
priority claim which was considered not to have been made shall not be
included in that communication.

---SECTION---114 Electronic Transmission of Notices

Where the Treaty, the Regulations, or these Administrative Instructions
provide for a notification or other communication to be transmitted by
one national Office or intergovernmental organization to another, that
notification or communication, except where otherwise provided, may,
where so agreed by both the sender and the receiver, be transmitted by
electronic means or in electronic form.

---SECTION---115 Indications of States, Territories, and
Intergovernmental Organizations

The indication of a State, territory, or intergovernmental organization
shall be made either by its full name, by a generally accepted short
title which, if the indications are in English or French, shall be as
appears in WIPO Standard ST.3 (Recommended Standard Two-Letter Code for
the Representation of Countries, and of Other Entities and International
Organizations Issuing or Registering Industrial Property Titles), or by
the two-letter code as appears in that Standard.

[FIGURE]

 ---SECTION---INSTRUCTIONS RELATING TO THE INTERNATIONAL APPLICATION

---SECTION---201 Language of the International Application

The language in which the international application is filed shall
preferably be indicated in the request.

---SECTION---202 Kind of Protection

Where the applicant wishes his application to be treated in any
designated State as an application not for a patent but for the grant of
another kind of protection referred to in Article 43, he shall make the
indication in the request referred to in Rule 4.12(a) by inserting the
words "inventor's certificate," "utility certificate," "utility model"
(or "petty patent" for Australia), "patent of addition," "certificate of
addition", "inventor's certificate of addition" or "utility certificate
of addition," or their equivalent in the language of the international
application, immediately after the indication of the said State.

Where, in respect of a designated State which provides for the granting
of a patent and of a utility model, the applicant is seeking two kinds
of protection under Article 44, he shall make the indication referred to
in Rule 4.12(b) by inserting, immediately after the indication of that
State and in the language of the international application, the words
"and utility model."

---SECTION---203 Different Applicants for Different Designated States

Different applicants may be indicated for different States designated
for a regional patent.

Where a particular State has been designated for both a national patent
and a regional patent, the same applicant or applicants shall be
indicated for both designations.

---SECTION---204 Headings of the Parts of the Description

The headings of the parts of the description should be as follows:

for matter referred to in Rule 5.1(a)(i), "Technical Field";

for matter referred to in Rule 5.1(a)(ii), "Background Art";

for matter referred to in Rule 5.1(a)(iii), "Disclosure of Invention";

for matter referred to in Rule 5.1(a)(iv), "Brief Description of
Drawings";

for matter referred to in Rule 5.1(a)(v), "Best Mode for Carrying Out
the Invention," or, where appropriate, "Mode(s) for Carrying Out the
Invention";

for matter referred to in Rule 5.1(a)(vi), "Industrial Applicability";

for matter referred to in Rule 5.2(a), "Sequence Listing";

for matter referred to in Rule 5.2(b), "Sequence Listing Free Text."

---SECTION---205 Numbering and Identification of Claims Upon Amendment

Amendments to the claims under Article 19 or Article 34(2)(b) may be
made either by cancelling one or more entire claims, by adding one or
more new claims or by amending the text of one or more of the claims as
filed. All the claims appearing on a replacement sheet shall be numbered
in Arabic numerals. Where a claim is cancelled, no renumbering of the
other claims shall be required. In all cases where claims are
renumbered, they shall be renumbered consecutively.

The applicant shall, in the letter referred to in the second and third
sentences of Rule 46.5(a) or in the second and fourth sentences of Rule
66.8(a), indicate the differences between the claims as filed and the
claims as amended. He shall, in particular, indicate in the said letter,
in connection with each claim appearing in the international application
(it being understood that identical indications concerning several
claims may be grouped), whether:

the claim is unchanged;

the claim is cancelled;

the claim is new;

the claim replaces one or more claims as filed;

the claim is the result of the division of a claim as filed.

---SECTION---206 Unity of Invention

The determination by the International Searching Authority, the
International Preliminary Examining Authority and the designated and
elected Offices whether an international application complies with the
requirement of unity of invention under Rule 13 shall be made in
accordance with Annex B.

---SECTION---207 Arrangement of Elements and Numbering of Sheets of the
International Application

In effecting the sequential numbering of the sheets of the international
application in accordance with Rule 11.7, the elements of the
international application shall be placed in the following order: the
request, the description (other than any sequence listing part thereof),
the claims, the abstract, the drawings, the sequence listing part of the
description (where applicable).

The sequential numbering of the sheets shall be effected by using the
following separate series of numbering:

the first series applying to the request only and commencing with the
first sheet of the request,

the second series commencing with the first sheet of the description
(other than any sequence listing part thereof) and continuing through
the claims until the last sheet of the abstract,

if applicable, a further series applying to the sheets of the drawings
only and commencing with the first sheet of the drawings; the number of
each sheet of the drawings shall consist of two Arabic numerals
separated by a slant, the first being the sheet number and the second
being the total number of sheets of drawings (for example, 1/3, 2/3,
3/3), and

if applicable, preferably, a further series applying to the sequence
listing part of the description commencing with the first sheet of that
part.

---SECTION---208 Sequence Listings

Any nucleotide and/or amino acid sequence listing ("sequence listing")
filed as part of the international application, or furnished together
with the international application or subsequently (whether in printed
form or computer readable form), shall comply with Annex C.

---SECTION---209 Indications as to Deposited Biological Material on a
Separate Sheet

To the extent that any indication with respect to deposited biological
material is not contained in the description, it may be given on a
separate sheet. Where any such indication is so given, it shall
preferably be on Form PCT/RO/134 and, if furnished at the time of
filing, the said Form shall, subject to paragraph (b), preferably be
attached to the request and referred to in the check list referred to in
Rule 3.3(a)(ii).

For the purposes of the Japanese Patent Office when Japan is designated,
paragraph (a) applies only to the extent that the said Form or sheet is
included as one of the sheets of the description of the international
application at the time of filing.

---SECTION---210 Calculation of Designation Fee for the Purposes of
National and Regional Patents

Where the request of the international application contains a
designation of a Contracting State without an indication of the wish to
obtain a regional patent and also a designation of the same Contracting
State with an indication of the wish to obtain a regional patent and the
national law of the Contracting State does not contain a provision
referred to in Article 45(2), the designation fees shall be calculated
on the basis that a separate fee is payable in respect of the
designation of the Contracting State in addition to the designation fee
payable in respect of that Contracting State as a Contracting State or
as one of a group of Contracting States for which a regional patent is
sought.

 ---SECTION---INSTRUCTIONS RELATING TO THE RECEIVING OFFICE

---SECTION---301 Notification of Receipt of Purported International
Application

Before the determination under Article 11(1), the receiving Office may
notify the applicant of the receipt of the purported international
application. The notification should indicate the date of actual receipt
and the international application number of the purported international
application referred to in Section 307 as well as, where useful for
purposes of identification, the title of the invention.

---SECTION---302 Priority Claim Considered Not To Have Been Made

Where the receiving Office declares, under Rule 26 bis.2(b), that a
priority claim is considered not to have been made, that Office shall
enclose the priority claim concerned within square brackets, draw a line
between the square brackets, while still leaving legible the indications
concerned, and enter, in the margin, the words "NOT TO BE CONSIDERED FOR
PCT PROCEDURE (RO)" or their equivalent in the language of publication
of the international application, and shall notify the applicant
accordingly. If copies of the international application have already
been sent to the International Bureau and the International Searching
Authority, the receiving Office shall also notify that Bureau and that
Authority.

---SECTION---303 Deletion of Additional Matter in the Request

Where, under Rule 4.17(b), the receiving Office deletes ex officio any
matter contained in the request, it shall do so by enclosing such matter
within square brackets and entering, in the margin, the words "DELETED
BY RO" or their equivalent in the language of publication of the
international application, and shall notify the applicant accordingly.
If copies of the international application have already been sent to the
International Bureau and the International Searching Authority, the
receiving Office shall also notify that Bureau and that Authority.

---SECTION---304 Invitation to Pay Fees Before Date on Which They Are
Due

If the receiving Office finds, before the date on which they are due,
that the transmittal fee, the basic fee (including any supplement per
sheet over 30) or the search fee are lacking in whole or in part, it may
invite the applicant to pay the missing amounts within one month from
the date of receipt of the international application.

If the receiving Office finds, before the date on which they are due,
that the designation fees for designations made under Rule 4.9(a) are
lacking in whole or in part, it may invite the applicant to pay the
missing amount within the time limit applicable under Rule 15.4(b).

If the receiving Office finds that the applicant filed a written notice
under Rule 4.9(c)(i), but failed to pay the designation fees and/or the
confirmation fee under Rule 4.9(c)(ii) or that the amount paid is not
sufficient, it may invite the applicant to pay the missing amount within
the time limit under Rule 4.9(b)(ii).

---SECTION---305 Identifying the Copies of the International Application

Where, under Rule 11.1(a), the international application has been filed
in one copy, the receiving Office shall, after preparing under Rule
21.1(a) the additional copies required under Article 12(1), mark,

the words "RECORD COPY" in the upper left-hand corner of the first page
of the original copy,

in the same space on one additional copy, the words "SEARCH COPY", and

in the same space on the other such copy, the words "HOME COPY," or
their equivalent in the language of publication of the international
application.

Where, under Rule 11.1(b), the international application has been filed
in more than one copy, the receiving Office shall choose the copy most
suitable for reproduction purposes, and mark the words "RECORD COPY," or
their equivalent in the language of publication of the international
application, in the upper left-hand corner of its first page. After
verifying the identity of any additional copies and, if applicable,
preparing under Rule 21.1(b) the home copy, it shall mark, in the upper
left-hand corner of the first page of one such copy, the words "SEARCH
COPY, " and, in the same space on the other such copy, the words "HOME
COPY," or their equivalent in the language of publication of the
international application.

---SECTION---305 Preparation, Identification and Transmittal of the
Copies of the Translation of the International Application

Where a translation of the international application is furnished under
Rule 12.3, the receiving Office shall:

be responsible for the prompt preparation of any additional copies
required where the translation is furnished in less than the number of
copies required for the purposes of this Section, and shall have the
right to fix a fee for performing that task and to collect such fee from
the applicant;

mark the words "RECORD COPY- TRANSLATION (RULE 12.3)" in the upper
left-hand corner of the first page of the original copy of the
translation and transmit that copy to the International Bureau;

mark the words "SEARCH COPY- TRANSLATION (RULE 12.3)" in the same space
on one additional copy of the translation which, together with a copy of
the request marked "SEARCH COPY" under Section 305(a)(ii), is considered
pursuant to Rule 23.1(b) to be the search copy, and transmit such search
copy to the International Searching Authority; and

mark the words "HOME COPY- TRANSLATION (RULE 12.3)" in the same space on
the other such copy of the translation, and keep that copy in its files.

The receiving Office may, when marking the copies of the translation
under paragraph (a), use, instead of the words referred to in that
paragraph, the equivalent of those words in the language of publication
of the international application.

---SECTION---306 Delayed Transmittal of Search Copy

Where the search copy will be transmitted to the International Searching
Authority after the date on which the record copy is transmitted to the
International Bureau, the receiving Office shall notify the
International Bureau. The notification may be made by marking a
check-box provided for this purpose on the request.

---SECTION---307 System of Numbering International Applications

Papers purporting to be an international application under Rule 20.1(a)
shall be marked with the international application number, consisting of
the letters "PCT," a slant, the two-letter code referred to in Section
115, indicating the receiving Office, a two-digit indication of the last
two numbers of the year in which such papers were first received, a
slant, and a five-digit number, allotted in sequential order
corresponding to the order in which the international applications are
received (e.g., "PCT/SE78/00001" ). Where the International Bureau acts,
pursuant to Rule 19.1(b), as receiving Office for a national Office, the
two-letter code indicating the national Office for which the
International Bureau acts as receiving Office shall be used.

If a negative determination is made under Rule 20.7 or a declaration is
made under Article 14(4), the letters "PCT" shall be deleted by the
receiving Office from the indication of the international application
number on any papers marked previously with that number, and the said
number shall be used without such letters in any future correspondence
relating to the purported international application.

---SECTION---308 Marking of the Sheets of the International Application
and of the Translation Thereof

The receiving Office shall indelibly mark the international application
number referred to in Section 307 in the upper right-hand corner of each
sheet of each copy of the purported international application and of any
translation of the international application furnished under Rule 12.3.

---SECTION---309 Procedure in the Case of Later Submitted Sheets

The receiving Office shall indelibly mark any sheet received on a date
later than the date on which sheets were first received with the date on
which it received that sheet, inserted immediately below the
international application number referred to in Section 307.

The receiving Office shall, in the case of later submitted sheets
received within the time limits referred to in Rule 20.2(a)(i) and (ii):

effect the required correction of the international filing date, or,
where no international filing date has yet been accorded, of the date of
receipt of the purported international application;

notify the applicant of the correction effected under item (i), above;

where transmittals under Article 12(1) have already been made, notify
the International Bureau and the International Searching Authority of
any correction effected under item (i), above, by transmitting a copy of
the corrected first and last sheets of the request, and forward the
later submitted sheets to the said Bureau and a copy thereof to the said
Authority;

where transmittals under Article 12(1) have not yet been made, attach
the later submitted sheets to the record copy and a copy thereof to the
search copy.

The receiving Office shall, in the case of later submitted sheets
received after the expiration of the time limit referred to in Rule
20.2(a)(i):

notify the applicant of that fact and of the date of receipt of the
later submitted sheets;

where transmittals under Article 12(1) have already been made, forward
the later submitted sheets to the International Bureau with the
indication on the bottom of each sheet of the words: "NOT TO BE TAKEN
INTO CONSIDERATION FOR THE PURPOSES OF INTERNATIONAL PROCESSING" or
their equivalent in the language of publication of the international
application;

where transmittals under Article 12(1) have not yet been made, attach
the later submitted sheets to the record copy with the indication
referred to in item (ii).

The receiving Office shall, in the case of later submitted sheets
received after the expiration of the time limit referred to in Rule
20.2(a)(ii), proceed as provided in Rule 20.7, unless the applicant has,
within the said time limit, complied with the invitation under Article
11(2)(a) so that an international filing date can be accorded; in the
latter case, the receiving Office shall proceed as provided in paragraph
(c)(i) to (iii).

---SECTION---310 Procedure in the Case of Missing Drawings

Where the international application refers to drawings which in fact are
not included in that application, the receiving Office shall make the
indication referred to in Rule 26.6(a) by marking a check-box provided
for this purpose on the request.

Section 309(a) shall apply also in the case of drawings received by the
receiving Office on a date later than the date on which sheets were
first received by that Office.

The receiving Office shall, in the case of missing drawings received
within the time limit referred to in Rule 20.2(a)(iii):

effect the required correction of the international filing date, or,
where no international filing date has yet been accorded, of the date of
receipt of the purported international application, and delete the
indication made under paragraph (a), above;

notify the applicant of the correction effected under item (i), above;

where transmittals under Article 12(1) have already been made, notify
the International Bureau and the International Searching Authority of
any correction effected under item (i), above, by transmitting a copy of
the corrected first and last sheets of the request, and forward the
later submitted drawings to the said Bureau and a copy thereof to the
said Authority;

where transmittals under Article 12(1) have not yet been made, attach
the later submitted drawings to the record copy and a copy thereof to
the search copy.

The receiving Office shall, in the case of missing drawings received
after the expiration of the time limit referred to in Rule 20.2(a)(iii):

notify the applicant of the fact and of the date of receipt of the later
submitted drawings;

where transmittals under Article 12(1) have already been made, forward
the later submitted drawings to the International Bureau with the
indication on the bottom of each drawing of the words: "NOT TO BE TAKEN
INTO CONSIDERATION (PCT Art. 14(2), 2nd sentence)" or their equivalent
in the language of publication of the international application;

where transmittals under Article 12(1) have not yet been made, attach
the later submitted drawings to the record copy with the indication
referred to in item (ii).

---SECTION---311 Renumbering in the Case of Deletion, Substitution or
Addition of Sheets of the International Application and of the
Translation Thereof

The receiving Office shall, subject to Section 207, sequentially
renumber the sheets of the international application when necessitated
by the addition of any new sheet, the deletion of entire sheets, a
change in the order of the sheets or any other reason.

The sheets of the international application shall be provisionally
renumbered in the following manner:

when a sheet is deleted, the receiving Office shall either include a
blank sheet with the same number and with the word "DELETED," or its
equivalent in the language of publication of the international
application, below the number, or insert, in brackets, below the number
of the following sheet, the number of the deleted sheet with the word
"DELETED" or its equivalent in the language of publication of the
international application;

when one or more sheets are added, each sheet shall be identified by the
number of the preceding sheet followed by a slant and then by another
Arabic numeral such that the additional sheets are numbered
consecutively, starting always with number one for the first sheet added
after an unchanged sheet (e.g., 10/1, 15/1, 15/2, 15/3, etc.); when
later additions of sheets to an existing series of added sheets are
necessary, an extra numeral shall be used for identifying the further
additions (e.g., 15/1, 15/1/1, 15/1/2, 15/2, etc.).

[Deleted]

In the cases mentioned in paragraph (b), it is recommended that the
receiving Office should write, below the number of the last sheet, the
total number of the sheets of the international application followed by
the words "TOTAL OF SHEETS" or their equivalent in the language of
publication of the international application. It is further recommended
that, at the bottom of any last sheet added, the words "LAST ADDED
SHEET" or their equivalent in the language of publication of the
international application should be inserted.

Paragraphs (a) to (c) shall apply mutatis mutandis to any translation of
the international application furnished under Rule 12.3.

---SECTION---312 Notification of Decision Not To Issue Declaration that
the International Application Is Considered Withdrawn

Where the receiving Office, after having notified the applicant under
Rule 29.4 of its intent to issue a declaration under Article 14(4),
decides not to issue such a declaration, it shall notify the applicant
accordingly.

---SECTION---313 Documents Filed with the International Application;
Manner of Marking the Necessary Annotations in the Check List

Any power of attorney, any priority document, any fee calculation sheet
and any separate sheet referred to in Section 209(a) containing
indications as to deposited biological material, filed with the
international application shall accompany the record copy; any other
document referred to in Rule 3.3(a)(ii) shall be sent only at the
specific request of the International Bureau. If any document which is
indicated in the check list as accompanying the international
application is not, in fact, filed at the latest by the time the record
copy leaves the receiving Office, that Office shall so note on the check
list and the said indication shall be considered as if it had not been
made.

Where, under Rule 3.3(b), the receiving Office itself completes the
check list, that Office shall enter, in the margin, the words "COMPLETED
BY RO" or their equivalent in the language of publication of the
international application. Where only some of the indications are
completed by the receiving Office, the said words and each indication
completed by that Office shall be identified by an asterisk.

Any sequence listing in computer readable form furnished to the
receiving Office, or any sequence listing in printed form furnished to
the receiving Office subsequent to the filing of the international
application, shall be transmitted to the International Searching
Authority together with the search copy. Where such a sequence listing
is received by the receiving Office after the transmittal of the search
copy, that sequence listing shall be promptly transmitted to the
International Searching Authority.

---SECTION---314 Correction or Addition of a Priority Claim Under Rule
26 bis

Where the applicant, in a notice submitted to the receiving Office,
corrects or adds a priority claim under Rule 26 bis, that Office shall
enter the correction or addition in the request, draw a line through,
while still leaving legible, any indication deleted as a result of the
correction, and enter, in the margin, the letters "RO."

The applicant and, if copies of the international application have
already been sent to the International Bureau and the International
Searching Authority, that Bureau and that Authority shall be promptly
notified by the receiving Office of any correction or addition of a
priority claim under Rule 26 bis and of the date on which it received
such correction or addition.

---SECTION---315 Notification Concerning Confirmation of Designation

Where a designation made under Rule 4.9(b) has been confirmed under Rule
4.9(c), the receiving Office shall promptly notify the applicant and the
International Bureau.

---SECTION---316 Procedure in the Case Where the International
Application Lacks the Prescribed Signature

Where, under Article 14(1)(a)(i), the receiving Office finds that the
international application is defective in that it lacks the prescribed
signature, that Office shall send to the applicant, together with the
invitation to correct under Article 14(1)(b), a copy of the relevant
sheet of the request part of the international application. The
applicant shall, within the prescribed time limit, return said copy
after affixing thereto the prescribed signature.

---SECTION---317 [Deleted]

---SECTION---318 Cancellation of Designations of Non-Contracting States

The receiving Office shall cancel ex officio the designation of any
State which is not a Contracting State, shall enclose that designation
within square brackets, shall draw a line between the square brackets
while still leaving the designation legible, shall enter, in the margin,
the words "CANCELLED EX OFFICIO BY RO" or their equivalent in the
language of publication of the international application, and shall
promptly notify the applicant accordingly. If the record copy has
already been sent to the International Bureau, the receiving Office
shall also notify that Bureau.

---SECTION---319 [Deleted]

---SECTION---320 Invitation to Pay Fees under Rule 16 bis .1(a) and (b)

If invitations to pay fees are required to be issued by the receiving
Office under both paragraph (a) and paragraph (b) of Rule 16 bis.1,
those invitations may be issued as separate invitations unless the due
dates for the fees concerned are less than 15 days apart, in which case
those invitations shall preferably be issued as a single invitation.

Where the receiving Office requires the payment of the late payment fee
under Rule 16 bis.2, it shall calculate the amount of that fee on the
basis of the total amount of the fees due referred to in the invitation
under paragraph (a).

When issuing an invitation under paragraph (a),the receiving Office
shall, if it received moneys from the applicant before the due date,
inform the applicant of the fees to which those moneys have been
applied.

---SECTION---321
Application of Moneys Received by the Receiving Office in Certain Cases

The receiving Office shall, to the extent that it has received
instructions from the applicant as to the fees to which it shall apply
moneys received by it from the applicant, apply those moneys
accordingly.

Where the receiving Office receives moneys from the applicant which,
together with any other moneys so received, are not sufficient to cover
in full the transmittal fee (if any), the international fee and the
search fee (if any), the receiving Office shall, to the extent that it
has not received instructions from the applicant as to the fees to which
it shall apply the moneys which are available for the purpose, apply
those moneys in payment, successively, of the fees set out below to the
extent that they are due and unpaid and in the order in which they
appear below:

the transmittal fee;

the basic fee part of the international fee;

the search fee;

the designation fee part of the international fee for designations made
under Rule 4.9(a).

Where, pursuant to paragraph (b), the receiving Office allocates moneys
in payment of the designation fees to cover designations made under Rule
4.9(a), it shall apply them to those fees as follows:

where the applicant indicates to which designation or designations the
amount is to be applied, it shall be applied accordingly but, if the
amount received is insufficient to cover the designations indicated, it
shall be applied in the order chosen by the applicant in indicating the
designations;

to the extent that the applicant has not given the indications referred
to in item (i), the amount, or the balance thereof, shall be applied to
the designations in the order in which they appear in the request part
of the international application;

where the designation of a State is for the purposes of a regional
patent, and provided that the required designation fee is, under the
preceding provisions, available for that designation, the designation of
any further States for which the same regional patent is sought shall be
considered as covered by that fee.

Where the receiving Office receives moneys from the applicant in
response to an invitation under Rule 16 bis.1 which are not sufficient
to cover all the unpaid fees, including, where required, the late
payment fee under Rule 16 bis.2, the moneys shall be applied in the
order referred to in paragraphs (b) and (c) to as many of the fees due,
including any late payment fee, as can be covered.

Where, pursuant to Rule 15.5(b), the receiving Office allocates moneys
in payment of fees under Rule 15.5(a) in respect of the confirmation
under Rule 4.9(c) of designations made under Rule 4.9(b), the receiving
Office shall apply those moneys as follows:

where the applicant indicates to which designation or designations the
amount is to be applied, it shall be applied accordingly, but, if the
amount is insufficient to cover the designations indicated, it shall be
applied to the designations in the order chosen by the applicant in
indicating the designations;

to the extent that the applicant has not given the indications referred
to in item (i), the amount, or the balance thereof, shall be applied to
the designations in the order in which they appear in the notice
containing the confirmation;

where the designation of a State is for the purposes of a regional
patent, and provided that the required designation fee is, under the
preceding provisions, available for that designation, the designation of
any further States for which the same regional patent is sought shall be
considered as covered by that fee.

When allocating moneys as provided in paragraph (e), both the
designation fee and the confirmation fee must be covered in respect of
each designation.

Where moneys have been applied by the receiving Office in accordance
with indications given by the applicant as mentioned in paragraph (c)(i)
or (e)(i), the receiving Office shall inform the International Bureau as
to the effect of the said indications, preferably by sending the
International Bureau a copy of any relevant written communication
received from the applicant.

---SECTION---322 Invitation to Submit a Request for Refund of the Search
Fee

The receiving Office may, before making a refund of the search fee under
Rule 16.2, first invite the applicant to submit a request for the
refund.

---SECTION---323 Transmittal of Priority Documents to International
Bureau

Any priority document which is submitted to the receiving Office under
Rule 17.1(a) shall be transmitted by that Office to the International
Bureau together with the record copy or, if received after the record
copy has been sent to the International Bureau, promptly after having
been received by that Office.

Where the priority document is issued by the receiving Office and the
applicant has, not later than 16 months after the priority date,
requested the receiving Office under Rule 17.1(b) to prepare and
transmit it to the International Bureau, the receiving Office shall,
promptly after receipt of such request ("request for priority document")
and, where applicable, the payment of the fee referred to in that Rule,
transmit the priority document to the International Bureau. Where such
request for priority document has been made but the required fee has not
been paid, the receiving Office shall promptly notify the applicant that
the request for priority document will be considered not to have been
made unless the fee is paid not later than 16 months after the priority
date or, in the case referred to in Article 23(2), not later than at the
time the processing or examination of the international application is
requested.

When transmitting a priority document, the receiving Office shall notify
the International Bureau of the date on which it received the priority
document or the request for priority document.

Where a request for priority document has, under paragraph (b), been
considered not to have been made, the receiving Office shall promptly
notify the International Bureau. Where the receiving Office fails to
notify the International Bureau accordingly within 17 months from the
priority date, the receiving Office shall prepare and transmit the
priority document to the International Bureau even though the required
fee has not been paid by the applicant.

Where a request for priority document has been received by the receiving
Office later than 16 months after the priority date, or where such
request has, under paragraph (b), been considered not to have been made,
the receiving Office shall promptly notify the applicant accordingly,
directing attention to the requirements of Rule 17.1(a).

---SECTION---324 Copy of Notification of the International Application
Number and the International Filing Date under Rule 20.5(c)

The copy, sent to the International Bureau, of the notification of the
international application number and the international filing date under
Rule 20.5(c) shall also include, if the priority of an earlier
application is claimed in the international application, the date of
filing-as indicated in the international application-of that earlier
application. If the priority of several earlier applications is claimed,
the earliest filing date shall be indicated.

---SECTION---325 Corrections of Defects Under Rule 26.4(a),
Rectifications of Obvious Errors Under Rule 91.1, and Corrections Under
Rule 9.2

Where the receiving Office receives a correction of defects under Rule
26.4(a) or authorizes a rectification of an obvious error under Rule
91.1, it shall:

indelibly mark, in the upper right-hand corner of each replacement
sheet, the international application number and the date on which that
sheet was received;

indelibly mark, in the middle of the bottom margin of each replacement
sheet, the words "SUBSTITUTE SHEET (RULE 26)" (where the replacement
sheet contains a correction of defects under Rule 26) or "RECTIFIED
SHEET (RULE 91.1)" (where the replacement sheet contains the
rectification of an obvious error under Rule 91.1) or their equivalent
in the language of publication of the international application;

indelibly mark on the letter containing the correction or rectification,
or accompanying any replacement sheet, the date on which that letter was
received;

keep in its files a copy of the letter containing the correction or
rectification or, when the correction or rectification is contained in a
replacement sheet, the replaced sheet, a copy of the letter accompanying
the replacement sheet, and a copy of the replacement sheet;

subject to item (vi), promptly transmit any letter and any replacement
sheet to the International Bureau, and a copy thereof to the
International Searching Authority;

where transmittals under Article 12(1) have not yet been made, transmit
any letter and any replacement sheet to the International Bureau
together with the record copy and, except where the international
application is considered withdrawn and Rule 29.1(a)(iii) applies, a
copy of the said letter or replacement sheet to the International
Searching Authority together with the search copy. The record copy and
the search copy shall contain any replaced sheet.

Where the receiving Office refuses to authorize the rectification of an
obvious error under Rule 91.1, it shall proceed as indicated under
paragraph (a)(i), (iii) and (iv) and promptly transmit any letter and
any proposed replacement sheet to the International Bureau. If the
record copy has not yet been sent to the International Bureau, any
letter and any proposed replacement sheet shall be transmitted together
with the record copy.

Where the receiving Office receives corrections aimed at complying with
Rule 9.1, paragraphs (a) and (b) shall apply mutatis mutandis, provided
that, where a sheet is marked as indicated in paragraph (a)(ii), the
words "SUBSTITUTE SHEET (RULE 9.2)" shall be used.

---SECTION---326 Withdrawal by Applicant Under Rule 90 bis .1, 90 bis .2
or 90 bis .3

The receiving Office shall promptly transmit to the International Bureau
any notice from the applicant effecting withdrawal of the international
application under Rule 90 bis.1, of a designation under Rule 90 bis.2 or
of a priority claim under Rule 90 bis.3 which has been filed with it
together with an indication of the date of receipt of the notice. If the
record copy has not yet been sent to the International Bureau, the
receiving Office shall transmit the said notice together with the record
copy.

If the search copy has already been sent to the International Searching
Authority and the international application is withdrawn under Rule 90
bis.1 or a priority claim is withdrawn under Rule 90 bis.3, the
receiving Office shall promptly transmit a copy of the notice effecting
withdrawal to the International Searching Authority.

If the search copy has not yet been sent to the International Searching
Authority and the international application is withdrawn under Rule 90
bis.1, the receiving Office shall not send the search copy to the
International Searching Authority and shall, subject to Section 322,
refund the search fee to the applicant unless it has already been
transferred to the International Searching Authority. If the search fee
has already been transferred to the International Searching Authority,
the receiving Office shall send a copy of the request and of the notice
effecting withdrawal to that Authority.

If the search copy has not yet been sent to the International Searching
Authority and a priority claim is withdrawn under Rule 90 bis.3, the
receiving Office shall transmit a copy of the notice effecting
withdrawal to the International Searching Authority together with the
search copy.

---SECTION---327 Ex Officio Correction of Request by the Receiving
Office

Where the record copy has not yet been sent to the International Bureau
and the request requires correction because it contains an inconsistency
or a minor defect such as noncompliance with the requirement for
indications under Section 115, the receiving Office may correct the
request ex officio. If the receiving Office does so, it shall notify the
applicant accordingly.

When making a correction under paragraph (a), the receiving Office shall
enter, in the margin, the letters "RO." Where any matter is to be
deleted, the receiving Office shall enclose such matter within square
brackets and shall draw a line between the square brackets while still
leaving the deleted matter legible. Where any matter is to be replaced,
both the first and second sentences of this paragraph shall apply.

The receiving Office shall check the number of characters of the file
reference, if any, and shall delete any characters beyond the number
permitted by Section 109.

---SECTION---328 Notifications Concerning Representation

Where a power of attorney or a document containing the revocation or
renunciation of an appointment is submitted to the receiving Office and
the record and search copies have already been transmitted, the
receiving Office shall immediately notify the International Bureau and
the International Searching Authority by sending them a copy of the
power of attorney or document and request the International Bureau to
record a change in the indications concerning the agent or common
representative under Rule 92 bis.1(a)(ii).

If the record copy and/or search copy have not yet been transmitted by
the receiving Office, a copy of the power of attorney or document
containing the revocation or renunciation of an appointment shall be
transmitted by the receiving Office with the record copy and/or search
copy.

---SECTION---329 Correction of Indications Concerning the Applicant's
Residence or Nationality

Where, in response to an invitation to correct a defect under Article
11(1)(i), evidence is submitted indicating to the satisfaction of the
receiving Office that, in fact, the applicant had, on the date on which
the international application was actually received, the right to file
an international application with that receiving Office, the invitation
shall be considered to be an invitation to correct a defect under
Article 14(1)(a)(ii) and Rule 4.5 in the prescribed indications
concerning the applicant`s residence and/or nationality, and the
applicant may correct those indications accordingly. If such correction
is made, no defect shall be considered to exist under Article 11(1)(i).

---SECTION---330 Transmittal of Record Copy Prevented or Delayed by
National Security Prescriptions

Where prescriptions concerning national security prevent the transmittal
of the record copy by the receiving Office to the International Bureau
under Rule 22.1(a), the receiving Office shall notify the applicant and
the International Bureau accordingly.

The notifications under paragraph (a) shall be sent before the
expiration of 13 months from the priority date. Where the receiving
Office believes that national security clearance is imminent, it may
postpone the sending of the notifications, but shall send them before
the expiration of 17 months from the priority date if no clearance has
been given by that time.

---SECTION---331 Receipt of Confirmation Copy

Where, subject to Rule 92.4, the receiving Office receives an
international application by facsimile machine transmission and
subsequently receives the original of that international application, it
shall mark such original with the words "CONFIRMATION COPY" or their
equivalent in the language of publication of the international
application on the bottom of the first page of the request and on the
first page of the description. The marking under Section 325 is not
required in such a case. The international application as received by
facsimile machine transmission shall constitute the record copy. The
confirmation copy shall be transmitted to the International Bureau in
addition to the record copy.

---SECTION---332 Notification of Languages Accepted for the Filing of
International Applications

Each receiving Office shall notify the International Bureau of the
language or languages which, having regard to Rule 12.1(b), it is
prepared to accept under Rule 12.1(a) for the filing of international
applications.

Each receiving Office shall notify the International Bureau of any
change to the information notified under paragraph (a). If the change
means that the receiving Office is no longer prepared to accept the
filing of international applications in a language that it had
previously notified the International Bureau that it was prepared to
accept, the effective date of such change shall be two months after the
date of publication of the notification of the change in the Gazette
pursuant to Section 405 or such later date as may be determined by the
receiving Office.

Nothing in paragraph (a) or (b) prevents any receiving Office from
accepting, in a particular case, the filing of an international
application in a language that it has not notified the International
Bureau that it is prepared to accept.

---SECTION---333 Transmittal of International Application to the
International Bureau as Receiving Office

Where a national Office intends to proceed under Rule 19.4(b) having
regard to Rule 19.4(a)(i) or (ii), it shall, if it requires payment of
the fee referred to in Rule 19.4(b) and that fee has not already been
paid, promptly invite the applicant to pay that fee within a time limit
of 15 days from the date of the invitation.

Where a national Office intends to proceed under Rule 19.4(b) having
regard to Rule 19.4(a)(iii), it shall promptly request the International
Bureau as receiving Office to agree to the transmittal of the
international application. The International Bureau as receiving Office
shall promptly respond to that request. If the International Bureau as
receiving Office agrees to the transmittal, the national Office shall
promptly invite the applicant:

if the transmittal has not already been authorized by the applicant, to
submit to that Office, within a time limit of 15 days from the date of
the invitation, an authorization of the transmittal, and,

if the Office requires payment of the fee referred to in Rule 19.4(b)
and that fee has not already been paid, to pay that fee within the time
limit referred to in item (i).

The national Office:

need not proceed under Rule 19.4(b) having regard to Rule 19.4(a)(i) to
(iii) if the Office requires payment of the fee referred to in Rule
19.4(b) and the applicant does not pay that fee;

shall not proceed under Rule 19.4(b) having regard to Rule 19.4(a)(iii)
if the International Bureau as receiving Office does not agree to, or if
the applicant does not authorize, the transmittal of the international
application under Rule 19.4(a)(iii).

---SECTION---334 Notification to Applicant of Submission of Demand After
the Expiration of 19 Months from the Priority Date

Where the demand is submitted after the expiration of 19 months from the
priority date to a receiving Office, that Office shall promptly notify
the applicant accordingly, directing attention to the fact that the time
limit under Article 39(1)(a) does not apply, and shall proceed under
Rule 59.3.

 ---SECTION---INSTRUCTIONS RELATING TO THE INTERNATIONAL BUREAU

---SECTION---401 Marking of the Sheets of the Record Copy

The International Bureau shall, upon receipt of the record copy, mark
the date of receipt of the record copy in the appropriate space on the
request.

If the receiving Office has failed to mark any sheet as provided in
Sections 311 and 325, the marking which has not been made may be
inserted by the International Bureau.

---SECTION---402 Correction or Addition of a Priority Claim Under Rule
26 bis

Where the applicant, in a notice submitted to the International Bureau,
corrects or adds a priority claim under Rule 26 bis, that Bureau shall
enter the correction or addition in the request, draw a line through,
while still leaving legible, any indication deleted as a result of the
correction, and enter, in the margin, the letters "IB".

[Deleted]

The applicant, the receiving Office and the International Searching
Authority shall be promptly notified by the International Bureau of any
correction or addition of a priority claim under Rule 26 bis and of the
date on which it received such correction or addition.

Any designated Office which has been notified under Rule 24.2(b) of the
receipt of the record copy shall be notified by the International Bureau
of any correction or addition of a priority claim under Rule 26 bis.

---SECTION---403 Transmittal of Protest Against Payment of Additional
Fee and Decision Thereon Where International Application Is Considered
To Lack Unity of Invention

Where, under Rules 40.2(c) or 68.3(c), the International Bureau receives
a request from the applicant to forward to any designated or elected
Office the texts of both the protest against payment of an additional
fee as provided for in Articles 17(3)(a) and 34(3)(a) where the
international application is considered to lack unity of invention and
the decision thereon by the International Searching Authority or the
International Preliminary Examining Authority, as the case may be, it
shall proceed according to such request.

---SECTION---404 International Publication Number of International
Application

The International Bureau shall assign to each published international
application an international publication number which shall be different
from the international application number. The international publication
number shall be used on the pamphlet and in the Gazette entry. It shall
consist of the two-letter code WO followed by a two-digit designation of
the last two numbers of the year of publication, a slant, and a serial
number consisting of five digits (e.g., "WO78/12345").

---SECTION---405 Publication of Notifications of Languages Accepted for
the Filing of International Applications

The International Bureau shall promptly publish in the Gazette any
notification under Section 332(a) or (b).

---SECTION---406 Pamphlets

Pamphlets referred to in Rule 48.1 shall be published on a given day of
the week.

All pamphlets shall be of A4 size and shall be reproduced recto verso,
except that drawings shall be reproduced recto only.

The form and particulars of the front page of each pamphlet shall be
decided by the Director General.

---SECTION---407 The Gazette

The Gazette in paper form referred to in Rule 86.1(b)(i) shall be of A4
size and shall be reproduced recto verso.

The Gazette in electronic form referred to in Rule 86.1(b)(ii) shall be
made available on the Internet, on CD-ROM and by any other electronic
means as determined by the Director General. Details concerning the
availability of the Gazette in electronic form shall be published in the
Gazette in paper form.

In addition to the contents specified in Rule 86, the Gazette shall
contain, in respect of each published international application, the
data indicated in Annex D.

The information referred to in Rule 86.1(a)(v) shall be that which is
indicated in Annex E.

---SECTION---408 Priority Application Number

[Deleted]

If the number of the earlier application referred to in Rule 4.10(a)(ii)
("priority application number") is furnished after the expiration of the
prescribed time limit, the International Bureau shall inform the
applicant and the designated Offices of the date on which the said
number was furnished. It shall indicate the said date in the
international publication by including on the front page of the pamphlet
next to the priority application number the words "FURNISHED LATE ON ...
(date)," and the equivalent of such words in the language in which the
international application is published if that language is other than
English.

If the priority application number has not been furnished at the time of
the completion of the technical preparations for international
publication, the International Bureau shall indicate that fact by
including on the front page of the pamphlet in the space provided for
the priority application number the words "NOT FURNISHED" and the
equivalent of such words in the language in which the international
application is published if that language is other than English.

---SECTION---409 Priority Claim Considered Not To Have Been Made

Where the International Bureau declares, under Rule 26 bis.2(b), that a
priority claim is considered not to have been made, that Bureau shall
enclose the priority claim concerned within square brackets, draw a line
between the square brackets, while still leaving legible the indications
concerned, and enter, in the margin, the words "NOT TO BE CONSIDERED FOR
PCT PROCEDURE (IB)" or their equivalent in the language of publication
of the international application, and shall notify the applicant
accordingly. The International Bureau shall also notify the receiving
Office and the International Searching Authority.

---SECTION---410 Numbering of Sheets for the Purposes of International
Publication; Procedure in Case of Missing Sheets or Drawings

In the course of preparing the international application for
international publication, the International Bureau shall sequentially
renumber the sheets to be published only when necessitated by the
addition of any new sheet, the deletion of entire sheets or a change in
the order of the sheets. Otherwise, the numbering provided under Section
207 shall be maintained.

Where a sheet or a drawing has not been filed or is not to be taken into
consideration for the purposes of international processing under Section
309(c) or Section 310(d), the International Bureau shall include an
indication to that effect in the pamphlet.

---SECTION---411 Receipt of Priority Document

The International Bureau shall mark, on the first page of the priority
document:

the date on which the priority document has been received by it, and

the words "PRIORITY DOCUMENT SUBMITTED OR TRANSMITTED IN COMPLIANCE WITH
RULE 17.1(a) OR (b)" or the words "PRIORITY DOCUMENT SUBMITTED OR
TRANSMITTED BUT NOT IN COMPLIANCE WITH RULE 17.1(a) OR (b)," as
applicable, or their equivalent in French, and shall notify the
applicant and, preferably together with the notification under Rule
47.1(a bis), the designated Offices, accordingly.

Where the priority document has been submitted or transmitted but not in
compliance with Rule 17.1(a) or (b), the International Bureau shall, in
the notification under paragraph (a) of this Section, direct the
attention of the applicant and the designated Offices to the provisions
of Rule 17.1(c).

---SECTION---412 Notification of Lack of Transmittal of Search Copy

If the International Bureau does not receive from the International
Searching Authority a notification under Rule 25.1 within two months
from the date of receipt of the record copy, the International Bureau
shall remind the receiving Office to transmit the search copy to the
International Searching Authority. A copy of the reminder shall be sent
to the International Searching Authority.

---SECTION---413 Corrections of Defects under Rule 26.4(a),
Rectifications of Obvious Errors under Rule 91.1, and Corrections under
Rule 9.2

Where the International Bureau receives from the receiving Office a
letter containing a correction of any defects under Rule 26.4(a), or a
replacement sheet and the letter accompanying it, the International
Bureau shall transfer the correction to the record copy, together with
the indication of the date on which the receiving Office received the
letter, or shall insert the replacement sheet in the record copy. Any
letter and any replaced sheet shall be kept in the file of the
international application.

Paragraph (a) shall apply mutatis mutandis to rectifications of obvious
errors authorized by the receiving Office or by the International
Searching Authority under Rule 91.1 and to corrections submitted by the
applicant to the receiving Office or the International Searching
Authority aimed at complying with the prescription of Rule 9.1
concerning certain expressions, drawings, statements or other matter.

---SECTION---414 Notification to the International Preliminary Examining
Authority Where the International Application or the Designations of All
Elected States Are Considered Withdrawn

If a demand has been submitted and the international application or the
designations of all designated States which have been elected are
considered withdrawn under Article 14(1), (3), or (4), the International
Bureau shall promptly notify the International Preliminary Examining
Authority, unless the international preliminary examination report has
already issued.

---SECTION---415 Notification of Withdrawal under Rule 90 bis .1, 90 bis
.2, 90 bis .3 or 90 bis .4

The fact of withdrawal by the applicant of the international application
under Rule 90 bis.1, of designations under Rule 90 bis.2, or of a
priority claim under Rule 90 bis.3, together with the date on which the
notice effecting withdrawal reached the International Bureau, the
International Preliminary Examining Authority or the receiving Office,
shall be recorded by the International Bureau and promptly notified by
it to the receiving Office, the applicant, the designated Offices
affected by the withdrawal if they have already been notified of their
designation and, where the withdrawal concerns the international
application or a priority claim and where the international search
report or the declaration referred to in Article 17(2)(a) has not yet
issued, the International Searching Authority. However, where the
withdrawal concerns the international application and where the notice
effecting withdrawal was filed with the receiving Office before the
sending of the record copy to the International Bureau, that Bureau
shall send the notifications referred to in the preceding sentence and
in Rule 24.2(a) to the receiving Office and the applicant only.

If, at the time of the withdrawal of the international application under
Rule 90 bis.1, or of a priority claim under Rule 90 bis.3, a demand has
already been submitted and the international preliminary examination
report has not yet issued, the International Bureau shall, unless the
notice effecting withdrawal was submitted to the International
Preliminary Examining Authority, promptly notify the fact of withdrawal
to that Authority, together with the date on which the notice effecting
withdrawal has reached the International Bureau or the receiving Office.

The fact of withdrawal by the applicant of the demand or of one or more
elections under Rule 90 bis.4, together with the date on which the
notice effecting withdrawal was, or was considered to have been,
submitted to the International Bureau, shall be promptly notified by
that Bureau:

to the applicant,

to each elected Office affected by the withdrawal, except where it has
not yet been notified of its election, and

in the case of withdrawal of the demand or of all elections, to the
International Preliminary Examining Authority, unless the notice
effecting withdrawal was submitted to that Authority.

---SECTION---416 Correction of Request in Record Copy

Where the request requires correction as a consequence of the withdrawal
of a designation or of a change made under Rule 92 bis, the
International Bureau shall make the necessary correction in the record
copy and shall notify the applicant and the receiving Office
accordingly.

When making a correction under paragraph (a), the International Bureau
shall enter, in the margin, the letters "IB." Where the correction
involves the deletion or replacement of some matter, the International
Bureau shall enclose such matter within square brackets and shall draw a
line between the square brackets while still leaving the deleted or
replaced matter legible.

---SECTION---417 Processing of Amendments under Article 19

The International Bureau shall record the date on which, under Rule
46.1, any amendment made under Article 19 was received, shall notify the
applicant of that date and indicate it in any publication or copy issued
by it.

The International Bureau shall mark, in the upper right-hand corner of
each replacement sheet submitted under Rule 46.5(a), the international
application number the date on which that sheet was received under Rule
46.1 and, in the middle of the bottom margin, the words "AMENDED SHEET
(ARTICLE 19)." It shall keep in its files any replaced sheet, the letter
accompanying the replacement sheet or sheets, and any letter referred to
in the last sentence of Rule 46.5(a).

The International Bureau shall insert any replacement sheet in the
record copy and, in the case referred to in the last sentence of Rule
46.5(a), shall indicate the cancellations in the record copy.

If, at the time when the demand is received by the International Bureau,
the international search report has been established and no amendments
under Article 19 have been made, the International Bureau shall inform
the International Preliminary Examining Authority accordingly.

---SECTION---418 Notifications to Elected Offices Where the Demand or an
Election Is Considered Not To Have Been Submitted or Made

Where, after any elected Office has been notified of its election under
Article 31(7), the demand or the election is considered not to have been
submitted or made, the International Bureau shall notify the said Office
accordingly.

---SECTION---419 [Deleted]

---SECTION---420 Copy of International Application and International
Search Report for the International Preliminary Examining Authority

Where the International Preliminary Examining Authority is not part of
the same national Office or intergovernmental organization as the
International Searching Authority, the International Bureau shall,
promptly upon receipt of the international search report or, if the
demand was received after the international search report, promptly upon
receipt of the demand, send a copy of the international application and
the international search report to the International Preliminary
Examining Authority. In cases where, instead of the international search
report, a declaration under Article 17(2)(a) was issued, references in
the preceding sentence to the international search report shall be
considered references to the said declaration.

---SECTION---421 Invitation To Furnish a Copy of the Priority Document

Where a request for a copy of the application whose priority is claimed
in the international application is made under Rule 66.7(a) by the
International Preliminary Examining Authority before the International
Bureau has received the priority document under Rule 17.1, the
International Bureau shall, unless the applicable time limit referred to
in Rule 17.1(a) has already expired, inform the applicant of such
request and remind him of the requirements of Rule 17.1.

---SECTION---422 Notifications Concerning Changes Recorded under Rule 92
bis .1

The International Bureau shall give notifications concerning changes
recorded by it under Rule 92 bis.1(a), except changes which are the
subject of notifications under Section 425:

to the receiving Office;

as long as the international search report has not been established, to
the International Searching Authority;

to the designated Offices, unless the change has been recorded after the
expiration of the time limit referred to in Article 22(1) or unless the
change can be duly reflected in the pamphlet used for the purposes of
the communication of the international application under Article 20;

as long as the international preliminary examination report has not been
established, to the International Preliminary Examining Authority;

to the elected Offices, unless the change can be duly reflected in the
pamphlet used for the purposes of the communication of the international
application under Article 20;

to the applicant; where the change consists of a change in the person of
the applicant, the notification shall be sent to the earlier applicant
and the new applicant, provided that, where the earlier applicant and
the new applicant are represented by the same agent, one notification
only shall be sent to the said agent.

Where Rule 92 bis.1(b) applies, the International Bureau shall notify
the applicant accordingly and, if the change was requested by the
receiving Office, that Office.

---SECTION---423 Cancellation of Designations and Elections

The International Bureau shall, if the receiving Office has failed to do
so, cancel ex officio the designation of any State which is not a
Contracting State, shall enclose that designation within square
brackets, draw a line between the square brackets while still leaving
the designation legible, enter, in the margin, the words "CANCELLED EX
OFFICIO BY IB" or their equivalent in French, and notify the applicant
and the receiving Office accordingly.

The International Bureau shall cancel ex officio:

the election, in the demand or in a notice effecting a later election,
of any State which is not a designated State;

the election, in the demand, of any State not bound by Chapter II of the
Treaty, if the International Preliminary Examining Authority has failed
to do so;

the election, in a notice effecting a later election, of any State not
bound by Chapter II of the Treaty.

The International Bureau shall enclose the cancelled election within
square brackets, draw a line between the square brackets while still
leaving the election legible, enter, in the margin, the words "CANCELLED
EX OFFICIO BY IB" or their equivalent in French, and notify the
applicant and, if the election is in the demand, the International
Preliminary Examining Authoring accordingly.

---SECTION---424 [Deleted]

---SECTION---425 Notifications Concerning Representation

Where a power of attorney or a document containing the revocation or
renunciation of an appointment is submitted to the International Bureau,
the International Bureau shall immediately notify the receiving Office,
the International Searching Authority and the International Preliminary
Examining Authority by sending them a copy of the power of attorney or
document and shall record a change in the indications concerning the
agent or common representative under Rule 92 bis. In the case of a
renunciation of an appointment, the International Bureau shall also
notify the applicant. Where the International Bureau receives a
notification concerning representation under Section 328, it shall
immediately notify the International Preliminary Examining Authority
accordingly.

---SECTION---426 Notification of Designation under Rule 24.2(b)

Each designated Office having notified the International Bureau under
Rule 24.2(b) that it wishes to receive the notification under Rule
24.2(a) shall receive periodically, but at least once a month, a listing
of the international applications containing the designation(s) of the
State(s) for which that Office acts as a designated Office, including
designations made under Rule 4.9(a) and those made under Rule 4.9(b)
which have been confirmed under Rule 4.9(c). Such listing shall contain,
in respect of each designation:

the international application number,

the international filing date,

the name of the applicant, and

the earliest priority date claimed.

---SECTION---427 Publication of Notice of Confirmation of Designation

Where an international application has been published under Article
21(2)(b) before the confirmation of a designation under Rule 4.9(c), a
notice of that confirmation shall be published in the Gazette.

---SECTION---428 Publication of Notice of Later Election

Where a later election is made before the expiration of 19 months from
the priority date, a notice of that fact shall be published in the
Gazette.

---SECTION---429 Notice of Extension

Where a request for extension of the effects of an international
application to a successor State, made in accordance with Rule 32.1(c),
is received by the International Bureau after technical preparations for
international publication have been completed, a notice of this fact
shall be published in the Gazette.

---SECTION---430 Notification of Designations under Rule 32 (Extensions)

Where the request for extension is made under Rule 32.1(c), the
International Bureau shall promptly, but not before the international
publication of the international application, effect the communication
under Article 20 to the designated Office concerned, notify that Office
under Rule 47.1(a bis), and notify it of the date of the receipt of the
request for extension.

---SECTION---431 Publication of Notice of Submission of Demand

The publication in the Gazette of information on the demand and the
elected States concerned, as referred to in Rule 61.4, shall consist of
a notice indicating that a demand has been submitted prior to the
expiration of 19 months from the priority date and, as applicable,
indicating that all eligible States have been elected or, where not all
eligible States have been elected, indicating those eligible States
which have not been elected.

---SECTION---432 Notification to Applicant of Submission of Demand After
the Expiration of 19 Months from the Priority Date

Where the demand is submitted after the expiration of 19 months from the
priority date and subsequently transmitted to the International Bureau
under Rule 59.3(a), or where the demand is submitted after the
expiration of 19 months from the priority date to the International
Bureau, the International Bureau shall, together with the notification
sent to the applicant under Rule 59.3(c)(i) or the invitation sent to
the applicant under Rule 59.3(c)(ii), as the case may be, promptly
notify the applicant accordingly, directing attention to the fact that
the time limit under Article 39(1)(a) does not apply, and shall proceed
under Rule 59.3.

 ---SECTION---INSTRUCTIONS RELATING TO THE INTERNATIONAL SEARCHING
AUTHORITY

---SECTION---501 Corrections Submitted to the International Searching
Authority Concerning Expressions, etc., Not To Be Used in the
International Application

Where the International Searching Authority receives corrections aimed
at complying with Rule 9.1, Section 511 shall applymutatis mutandis,
provided that, where a sheet is marked as indicated in Section
511(a)(ii), the words "SUBSTITUTE SHEET (RULE 9.2)" shall be used.

---SECTION---502 Transmittal of Protest Against Payment of Additional
Fee and Decision Thereon Where International Application Is Considered
To Lack Unity of Invention

The International Searching Authority shall transmit to the applicant,
preferably at the latest together with the international search report,
any decision which it has taken under Rule 40.2(c) on the protest of the
applicant against payment of an additional fee where the international
application is considered to lack unity of invention. At the same time,
it shall transmit to the International Bureau a copy of both the protest
and the decision thereon, as well as any request by the applicant to
forward the texts of both the protest and the decision thereon to the
designated Offices.

---SECTION---503 Method of Identifying Documents Cited in the
International Search Report

Identification of any document cited in the international search report
shall be as provided in WIPO Standard ST.14 (Recommendation for the
Inclusion of References Cited in Patent Documents).

[FIGURE]

---SECTION---504 Classification of the Subject Matter of the
International Application

Where the subject matter of the international application is such that
classification thereof requires more than one classification symbol
according to the principles to be followed in the application of the
International Patent Classification to any given patent document, the
international search report shall indicate all such symbols.

Where any national classification system is used, the international
search report may indicate all the applicable classification symbols
also according to that system.

Where the subject matter of the international application is classified
both according to the International Patent Classification and to any
national classification system, the international search report shall,
wherever possible, indicate the corresponding symbols of both
classifications opposite each other.

The version of the International Patent Classification applicable at the
time the international application is published under Article 21 shall
be used whenever feasible.

---SECTION---505 Indication of Citations of Particular Relevance in the
International Search Report

Where any document cited in the international search report is of
particular relevance, the special indication required by Rule 43.5(c)
shall consist of the letter(s) "X" and/or "Y" placed next to the
citation of the said document.

Category "X" is applicable where a document is such that when taken
alone, a claimed invention cannot be considered novel or cannot be
considered to involve an inventive step.

Category "Y" is applicable where a document is such that a claimed
invention cannot be considered to involve an inventive step when the
document is combined with one or more other such documents, such
combination being obvious to a person skilled in the art.

---SECTION---506 Comments on Draft Translation of the International
Application

Where the applicant has made comments, within the time limits fixed by
the International Searching Authority, on the draft translation prepared
under the responsibility of the International Searching Authority as
provided in Rule 48.3(b), that Authority shall notify the applicant
whether it has changed the draft translation and, if so, of the changes
it has made therein.

Where the applicant submits comments on the draft translation prepared
under the responsibility of the International Searching Authority after
the expiration of the time limits fixed by the International Searching
Authority, and that Authority changes the draft translation, it shall
notify the applicant accordingly.

---SECTION---507 Manner of Indicating Certain Special Categories of
Documents Cited in the International Search Report

Where any document cited in the international search report refers to an
oral disclosure, use, exhibition, or other means referred to in Rule
33.1(b), the separate indication required by that Rule shall consist of
the letter "O" placed next to the citation of the said document.

Where any document cited in the international search report is a
published application or patent as defined in Rule 33.1(c), the special
mention required by that Rule shall consist of the letter "E" placed
next to the citation of the said document.

Where any document cited in the international search report is not
considered to be of particular relevance requiring the use of categories
"X" and/or "Y" as provided in Section 505 but defines the general state
of the art, it shall be indicated by the letter "A" placed next to the
citation of the said document.

[FIGURE]

Where any document cited in the international search report is a
document whose publication date occurred earlier than the international
filing date of the international application, but later than the
priority date claimed in that application, it shall be indicated by the
letter "P" next to the citation of the said document.

Where any document cited in the international search report is a
document whose publication date occurred after the filing date or the
priority date of the international application and is not in conflict
with the said application, but is cited for the principle or theory
underlying the invention, which may be useful for a better understanding
of the invention, or is cited to show that the reasoning or the facts
underlying the invention are incorrect, it shall be indicated by the
letter "T" next to the citation of the document.

Where in the international search report any document is cited for
reasons other than those referred to in paragraphs (a) to (e), for
example:

- a document which may throw doubt on a priority claim,

[FIGURE]

- a document cited to establish the publication date of another
citation,

[FIGURE] such document shall be indicated by the letter "L" next to the
citation of the document and the reason for citing the document shall be
given.

Where a document is a member of a patent family,

[FIGURE] it shall, whenever feasible, be mentioned in the international
search report in addition to the one cited belonging as well to this
family and should be preceded by the sign ampersand (&). Members of a
patent family may also be mentioned on a separate sheet, provided that
the family to which they belong shall be clearly identified and that any
text matter on that sheet, if not in the English language, shall also be
furnished to the International Bureau in English translation.

A document whose contents have not been verified by the search examiner
but are believed to be substantially identical with those of another
document which the search examiner has inspected, may be cited in the
international search report in the manner indicated for patent family
members in the first sentence of paragraph (g).

[FIGURE]

---SECTION---508 Manner of Indicating the Claims to Which the Documents
Cited in the International Search Report Are Relevant

The claims to which cited documents are relevant shall be indicated by
placing in the appropriate column of the international search report:

where the cited document is relevant to one claim, the number of that
claim; for example, "2" or "17";

where the cited document is relevant to two or more claims numbered in
consecutive order, the number of the first and last claims of the series
connected by a hyphen; for example, "1-15" or "2-3";

where the cited document is relevant to two or more claims that are not
numbered in consecutive order, the number of each claim placed in
ascending order and separated by a comma or commas; for example, "1, 6"
or "1, 7, 10";

where the cited document is relevant to more than one series of claims
under (ii), above, or to claims of both categories (ii) and (iii),
above, the series or individual claim numbers and series placed in
ascending order using commas to separate the several series, or to
separate the numbers of individual claims and each series of claims; for
example, "1-6, 9-10, 12-15 "or" 1, 3-4, 6, 9-11."

Where different categories apply to the same document cited in an
international search report in respect of different claims or groups of
claims, each relevant claim or group of claims shall be listed
separately opposite each indicated category of relevance. Each category
and each relevant claim or group of claims may be separated by a line.

The following example illustrates the situation where a document is of
particular relevance under Section 505(b) as to claims 1 to 3 and under
Section 505(c) as to claim 4, and indicates the general state of the art
under Section 507(c) as to claims 11 and 12:

Category

Citation Relevant to claim No.

GB, A 392,415 (JONES) 18 May 1933 (18.05.33)

X

Fig.1

1-3

Y

page 3, lines 5-7

4

A

Fig.5, support 36

11-12

---SECTION---509 International Search on the Basis of a Translation of
the International Application

Where the International Searching Authority has carried out the
international search on the basis of a translation of the international
application transmitted to that Authority under Rule 23.1(b), the
international search report shall so indicate.

---SECTION---510 Refund of Search Fee in Case of Withdrawal of
International Application

Where the international application is withdrawn or is considered
withdrawn before the International Searching Authority has started the
international search, that Authority shall, subject to paragraphs (b)
and (c), refund the search fee to the applicant.

If the refund referred to in paragraph (a) is not compatible with the
national law of the national Office acting as International Searching
Authority and as long as it continues to be not compatible with that
law, the International Searching Authority may abstain from refunding
the search fee.

The International Searching Authority may, before making a refund under
paragraph (a), first invite the applicant to submit a request for the
refund.

---SECTION---511 Rectifications of Obvious Errors under Rule 91.1

Where the International Searching Authority authorizes a rectification
under Rule 91.1, it shall:

indelibly mark, in the upper right-hand corner of each replacement
sheet, the international application number and the date on which that
sheet was received;

indelibly mark, in the middle of the bottom margin of each replacement
sheet, the words "RECTIFIED SHEET (RULE 91)'' or their equivalent in the
language of publication of the international application as well as an
indication of the International Searching Authority as provided for in
Section 107(b);

indelibly mark on the letter containing the rectification or
accompanying any replacement sheet the date on which that letter was
received;

keep in its files a copy of the letter containing the rectification or,
when the rectification is contained in a replacement sheet, the replaced
sheet, a copy of the letter accompanying the replacement sheet, and a
copy of the replacement sheet;

promptly transmit any letter and any replacement sheet to the
International Bureau and a copy thereof to the receiving Office.

Where the International Searching Authority refuses to authorize a
rectification under Rule 91.1, it shall proceed as indicated under
paragraph (a)(i), (iii), and (iv) and promptly transmit any letter and
any proposed replacement sheet to the International Bureau.

---SECTION---512 Notifications Concerning Representation

Where a power of attorney or a document containing the revocation or
renunciation of an appointment is submitted to the International
Searching Authority, that Authority shall immediately notify the
International Bureau by sending it a copy of the power of attorney or
document and request the International Bureau to record a change in the
indications concerning the agent or common representative under Rule 92
bis.1(a)(ii).

---SECTION---513 Sequence Listings

Where the International Searching Authority receives a correction of a
defect under Rule 13 ter.1(d), it shall:

indelibly mark, in the upper right-hand corner of each replacement
sheet, the international application number and the date on which that
sheet was received;

indelibly mark, in the middle of the bottom margin of each replacement
sheet, the words "SUBSTITUTE SHEET (RULE 13 ter.1(d))" or their
equivalent in the language of publication of the international
application;

indelibly mark on the letter containing the correction, or accompanying
any replacement sheet, the date on which that letter was received;

keep in its files a copy of the letter containing the correction or,
when the correction is contained in a replacement sheet, the replaced
sheet, a copy of the letter accompanying the replacement sheet, and a
copy of the replacement sheet;

promptly transmit any letter and any replacement sheet to the
International Bureau, and a copy thereof to the receiving Office.

Where the international search report is based on a sequence listing
that was not contained in the international application as filed but was
furnished subsequently to the International Searching Authority, the
international search report shall so indicate.

Where a meaningful international search cannot be carried out because a
sequence listing is not available to the International Searching
Authority in the required form, that Authority shall so state in the
international search report.

The International Searching Authority shall indelibly mark, in the upper
right-hand corner of the first sheet of any sequence listing in printed
form which was not contained in the international application as filed
but was furnished subsequently to that Authority, the words
"SUBSEQUENTLY FURNISHED SEQUENCE LISTING" or their equivalent in the
language of publication of the international application.

The International Searching Authority shall keep in its files:

any sequence listing in printed form which was not contained in the
international application as filed but was furnished subsequently to
that Authority; and

any sequence listing in computer readable form.

---SECTION---514 Authorized Officer

The officer of the International Searching Authority responsible for the
international search report, as referred to in Rule 43.8 means the
person who actually performed the search work and prepared the search
report or another person who was responsible for supervising the search.

---SECTION---515 Amendment of Established Abstract in Response to
Applicant's Comments

The International Searching Authority shall inform the applicant and the
International Bureau of any amendments made under Rule 38.2(b) to an
abstract established by it under Rule 38.2(a).

Section 516

---SECTION---516 Notification to Applicant of Submission of Demand After
the Expiration of 19 Months from the Priority Date

Where the demand is submitted after the expiration of 19 months from the
priority date to an International Searching Authority, that Authority
shall promptly notify the applicant accordingly, directing attention to
the fact that the time limit under Article 39(1)(a) does not apply, and
shall proceed under Rule 59.3.

 ---SECTION---INSTRUCTIONS RELATING TO THE INTERNATIONAL PRELIMINARY
EXAMINING AUTHORITY

---SECTION---601 Notice to Applicant of Submission of Demand After the
Expiration of 19 Months From the Priority Date

Where the demand is submitted after the expiration of 19 months from the
priority date, the International Preliminary Examining Authority shall
promptly notify the applicant accordingly, directing attention to the
fact that the time limit under Article 39(1)(a) does not apply.

Where the demand is submitted after the expiration of 19 months from the
priority date to an International Preliminary Examining Authority which
is not competent for the international preliminary examination of the
international application, that Authority shall promptly notify the
applicant accordingly, directing attention to the fact that the time
limit under Article 39(1)(a) does not apply, and shall proceed under
Rule 59.3.

---SECTION---602 Processing of Amendments by the International
Preliminary Examining Authority

The International Preliminary Examining Authority shall:

indelibly mark, in the upper right-hand corner of each replacement sheet
submitted under Rule 66.8, the international application number and the
date on which that sheet was received;

indelibly mark, in the middle of the bottom margin of each replacement
sheet, the words "AMENDED SHEET" or their equivalent in the language of
the demand as well as an indication of the International Preliminary
Examining Authority as provided for in Section 107(b);

keep in its files any replaced sheet, the letter accompanying any
replacement sheet, and any superseded replacement sheet or any letter
referred to in the last sentence of Rule 66.8(b) as well as a copy of
any replacement sheet which is annexed to the international preliminary
examination report;

annex to the copy of the international preliminary examination report
which is transmitted to the International Bureau any replacement sheet
as provided for under Rule 70.16;

annex to the copy of the international preliminary examination report
which is transmitted to the applicant a copy of each replacement sheet
as provided for under Rule 70.16.

Section 311(b)(ii) relating to the numbering of replacement sheets shall
apply when one or more sheets are added under Rule 66.8.

Where the International Preliminary Examining Authority receives from
the applicant a copy of a purported amendment under Article 19 submitted
after the time limit set forth in Rule 46.1, the International
Preliminary Examining Authority may consider such an amendment as an
amendment under Article 34 in which case it shall inform the applicant
accordingly.

Where the International Preliminary Examining Authority receives a copy
of an amendment under Article 19, paragraphs (a) and (b) shall apply
mutatis mutandis.

---SECTION---603 Transmittal of Protest Against Payment of Additional
Fee and Decision Thereon Where International Application Is Considered
To Lack Unity of Invention

The International Preliminary Examining Authority shall transmit to the
applicant, preferably at the latest together with the international
preliminary examination report, any decision which it has taken under
Rule 68.3(c) on the protest of the applicant against payment of an
additional fee where the international application is considered to lack
unity of invention. At the same time, it shall transmit to the
International Bureau a copy of both the protest and the decision
thereon, as well as any request by the applicant to forward the texts of
both the protest and the decision thereon to the elected Offices.

---SECTION---604 Guidelines for Explanations Contained in the
International Preliminary Examination Report

Explanations under Rule 70.8 shall clearly point out to which of the
three criteria of novelty, inventive step (nonobviousness) and
industrial applicability referred to in Article 35(2), taken separately,
any cited document is applicable and shall clearly describe, with
reference to the cited documents, the reasons supporting the conclusion
that any of the said criteria is or is not satisfied.

Explanations under Article 35(2) shall be concise and preferably in the
form of short sentences.

---SECTION---605 File To Be Used for International Preliminary
Examination

Where the International Preliminary Examining Authority is part of the
same national Office or intergovernmental organization as the
International Searching Authority, the same file shall serve the
purposes of international search and international preliminary
examination.

---SECTION---606 Cancellation of Elections

The International Preliminary Examining Authority shall, if the election
is in the demand, cancel ex officio the election of any State which is
not bound by Chapter II of the Treaty, shall enclose that election
within square brackets, shall draw a line between the square brackets
while still leaving the election legible and shall enter, in the margin,
the words "CANCELLED EX OFFICIO BY IPEA'' or their equivalent in the
language of the demand, and shall notify the applicant accordingly.

---SECTION---606 Procedure Where Election of a State Considered Not To
Have Been Made

Where under Rule 60.1(d), the election of a State is to be considered as
if it had not been made, the International Preliminary Examining
Authority shall indicate that fact in the demand by enclosing the
election of that State within square brackets, drawing a line between
the square brackets while still leaving the election legible, and
entering in the margin the words "CONSIDERED NOT TO HAVE BEEN MADE" or
their equivalent in the language of the demand.

---SECTION---607 Rectifications of Obvious Errors under Rule 91.1

Where the International Preliminary Examining Authority authorizes a
rectification of an obvious error under Rule 91.1, Rule 70.16 and
Section 602(a) and (b) shall apply mutatis mutandis, provided that,
where a sheet is marked as indicated in Section 602, the words
"RECTIFIED SHEET (RULE 91)'' shall be used.

Where the International Preliminary Examining Authority authorizes a
rectification of an obvious error under Rule 91.1, Rule 70.16 and
Section 602(a) and (b) shall apply mutatis mutandis.

---SECTION---608 Notifications Concerning Representation

Where a power of attorney or a document containing the revocation or
renunciation of an appointment is submitted to the International
Preliminary Examining Authority, that Authority shall immediately notify
the International Bureau by sending it a copy of the power of attorney
or document and request the International Bureau to record a change in
the indications concerning the agent or common representative under Rule
92 bis.1(a)(ii).

---SECTION---609 Withdrawal by Applicant under Rule 90 bis . 1, 90 bis .
2, or 90 bis . 3

The International Preliminary Examining Authority shall promptly
transmit to the International Bureau any notice from the applicant
effecting withdrawal of the international application under Rule 90
bis.1(b), of a designation under Rule 90 bis.2(d), or of a priority
claim under Rule 90 bis.3(c) which has been filed with it. The
International Preliminary Examining Authority shall mark the notice with
the date on which it was received.

---SECTION---610 [Deleted]

---SECTION---611 Method of Identification of Documents in the
International Preliminary Examination Report

Any document cited in the international preliminary examination report
which was not cited in the international search report shall be cited in
the same form as required under Section 503 for international search
reports. Any document cited in the international preliminary examination
report which was previously cited in the international search report may
be cited in a shortened form, provided that the document is unambiguous.

---SECTION---612 Authorized Officer

The officer of the International Preliminary Examining Authority
responsible for the international preliminary examination report, as
referred to in Rule 70.14, means the person who actually performed the
examination work and prepared the international preliminary examination
report or another person who was responsible for supervising the
examination.

---SECTION---613 Invitation to Submit a Request for Refund of Fees under
Rule 57.6 or 58.3

The International Preliminary Examining Authority may, before making a
refund under Rule 57.6 or 58.3, first invite the applicant to submit a
request for the refund.

---SECTION---614 Evidence of Right to File Demand

Where a demand is considered as not having been made under Rule 61.1(b)
by the International Preliminary Examining Authority because the
applicant appeared, on the basis of the indication made in the demand,
not to have the right to file a demand with that Authority under Rule 54
but evidence is submitted indicating to the satisfaction of the
International Preliminary Examining Authority that in fact, an applicant
had, on the date on which the demand was received, the right to file the
demand with that Authority, the International Preliminary Examining
Authority shall regard the requirements under Article 31(2)(a) as having
been fulfilled on the date of actual receipt of the demand.

---SECTION---615 Invitation to Pay Fees Before Date on Which They Are
Due

If the International Preliminary Examining Authority finds, before the
date on which they are due, that the handling fee or the international
preliminary examination fee are lacking in whole or in part, it may
invite the applicant to pay the missing amounts within the time limit
under Rule 57.3 or 58.1(b), as the case may be.

---SECTION---616 International Preliminary Examination on the Basis of a
Translation of the International Application

Where the International Preliminary Examining Authority has carried out
international preliminary examination on the basis of a translation of
the international application furnished to that Authority under Rule
55.2(a) or, in the case referred to in Rule 55.2(b), transmitted, under
Rule 23.1(b), to the national Office or intergovernmental organization
of which that Authority is part, the international preliminary
examination report shall so indicate.

A

FORMS

[This Annex, which is not reproduced here, contains all the Forms for
use by applicants and by the International Authorities, including those
referred to in Section 102 of these Administrative Instructions; it
consists of five Parts, which are published separately, as follows:

Part I: Forms Relating to the Receiving Office

Part II: Forms Relating to the International Searching Authority

Part III: Forms Relating to the International Bureau

Part IV: Forms Relating to the International Preliminary Examining
Authority

Part V: Request and Demand Forms]

---SECTION---B UNITY OF INVENTION
---SECTION---INSTRUCTIONS CONCERNING UNITY OF INVENTION
Unity of Invention.Rule 13.1 deals with the requirement of unity of
invention and states the principle that an international application
should relate to only one invention or, if there is more than one
invention, that the inclusion of those inventions in one international
application is only permitted if all inventions are so linked as to form
a single general inventive concept.

Technical Relationship.Rule 13.2 defines the method for determining
whether the requirement of unity of invention is satisfied in respect of
a group of inventions claimed in an international application. Unity of
invention exists only when there is a technical relationship among the
claimed inventions involving one or more of the same or corresponding
special technical features. The expression "special technical features"
is defined in Rule 13.2 as meaning those technical features that define
a contribution which each of the inventions, considered as a whole,
makes over the prior art. The determination is made on the contents of
the claims as interpreted in light of the description and drawings (if
any).

Independent and Dependent Claims.Unity of invention has to be considered
in the first place only in relation to the independent claims in an
international application and not the dependent claims. By "dependent"
claim is meant a claim which contains all the features of another claim
and is in the same category of claim as that other claim (the expression
"category of claim" referring to the classification of claims according
to the subject matter of the invention claimed for example, product,
process, use or apparatus or means, etc.).

If the independent claims avoid the prior art and satisfy the
requirement of unity of invention, no problem of lack of unity arises in
respect of any claims that depend on the independent claims. In
particular, it does not matter if a dependent claim itself contains a
further invention. Equally, no problem arises in the case of a
genus/species situation where the genus claim avoids the prior art.
Moreover, no problem arises in the case of a combination/subcombination
situation where the subcombination claim avoids the prior art and the
combination claim includes all the features of the subcombination.

If, however, an independent claim does not avoid the prior art, then the
question whether there is still an inventive link between all the claims
dependent on that claim needs to be carefully considered. If there is no
link remaining, an objection of lack of unity a posteriori (that is,
arising only after assessment of the prior art) may be raised. Similar
considerations apply in the case of a genus/species or
combination/subcombination situation.

This method for determining whether unity of invention exists is
intended to be applied even before the commencement of the international
search. Where a search of the prior art is made, an initial
determination of unity of invention, based on the assumption that the
claims avoid the prior art, may be reconsidered on the basis of the
results of the search of the prior art.

Illustrations of Particular Situations.There are three particular
situations for which the method for determining unity of invention
contained in Rule 13.2 is explained in greater detail:

combinations of different categories of claims;

so-called "Markush practice"; and

intermediate and final products.

Principles for the interpretation of the method contained in Rule 13.2,
in the context of each of those situations are set out below. It is
understood that the principles set out below are, in all instances,
interpretations of and not exceptions to the requirements of Rule 13.2.

Examples to assist in understanding the interpretation on the three
areas of special concern referred to in the preceding paragraph are set
out below.

Combinations of Different Categories of Claims.The method for
determining unity of invention under Rule 13 shall be construed as
permitting, in particular, the inclusion of any one of the following
combinations of claims of different categories in the same international
application:

in addition to an independent claim for a given product, an independent
claim for a process specially adapted for the manufacture of the said
product, and an independent claim for a use of the said product, or

in addition to an independent claim for a given process, an independent
claim for an apparatus or means specifically designed for carrying out
the said process, or

in addition to an independent claim for a given product, an independent
claim for a process specially adapted for the manufacture of the said
product and an independent claim for an apparatus or means specifically
designed for carrying out the said process, it being understood that a
process is specially adapted for the manufacture of a product if it
inherently results in the product and that an apparatus or means is
specifically designed for carrying out a process if the contribution
over the prior art of the apparatus or means corresponds to the
contribution the process makes over the prior art.

Thus, a process shall be considered to be specially adapted for the
manufacture of a product if the claimed process inherently results in
the claimed product with the technical relationship being present
between the claimed product and claimed process. The words "specially
adapted" are not intended to imply that the product could not also be
manufactured by a different process.

Also an apparatus or means shall be considered to be "specifically
designed for carrying out" a claimed process if the contribution over
the prior art of the apparatus or means corresponds to the contribution
the process makes over the prior art. Consequently, it would not be
sufficient that the apparatus or means is merely capable of being used
in carrying out the claimed process. However, the expression
"specifically designed" does not imply that the apparatus or means could
not be used for carrying out another process, nor that the process could
not be carried out using an alternative apparatus or means.

"Markush Practice." The situation involving the so-called "Markush
practice" wherein a single claim defines alternatives (chemical or
non-chemical) is also governed by Rule 13.2. In this special situation,
the requirement of a technical interrelationship and the same or
corresponding special technical features as defined in Rule 13.2, shall
be considered to be met when the alternatives are of a similar nature.

When the Markush grouping is for alternatives of chemical compounds,
they shall be regarded as being of a similar nature where the following
criteria are fulfilled:

all alternatives have a common property or activity, and

a common structure is present, i.e., a significant structural element is
shared by all of the alternatives, or

in cases where the common structure cannot be the unifying criteria, all
alternatives belong to a recognized class of chemical compounds in the
art to which the invention pertains.

In paragraph (f)(i)(B)(1), above, the words "significant structural
element is shared by all of the alternatives" refer to cases where the
compounds share a common chemical structure which occupies a large
portion of their structures, or in case the compounds have in common
only a small portion of their structures, the commonly shared structure
constitutes a structurally distinctive portion in view of existing prior
art. The structural element may be a single component or a combination
of individual components linked together.

In paragraph (f)(i)(B)(2), above, the words "recognized class of
chemical compounds" mean that there is an expectation from the knowledge
in the art that members of the class will behave in the same way in the
context of the claimed invention. In other words, each member could be
substituted one for the other, with the expectation that the same
intended result would be achieved.

The fact that the alternatives of a Markush grouping can be differently
classified shall not, taken alone, be considered to be justification for
a finding of a lack of unity of invention.

When dealing with alternatives, if it can be shown that at least one
Markush alternative is not novel over the prior art, the question of
unity of invention shall be reconsidered by the examiner.
Reconsideration does not necessarily imply that an objection of lack of
unity shall be raised.

Intermediate and Final Products.The situation involving intermediate and
final products is also governed by Rule 13.2.

The term "intermediate" is intended to mean intermediate or starting
products. Such products have the ability to be used to produce final
products through a physical or chemical change in which the intermediate
loses its identity.

Unity of invention shall be considered to be present in the context of
intermediate and final products where the following two conditions are
fulfilled:

the intermediate and final products have the same essential structural
element, in that:

the basic chemical structures of the intermediate and the final products
are the same, or

the chemical structures of the two products are technically closely
interrelated, the intermediate incorporating an essential structural
element into the final product, and

the intermediate and final products are technically interrelated, this
meaning that the final product is manufactured directly from the
intermediate or is separated from it by a small number of intermediates
all containing the same essential structural element.

Unity of invention may also be considered to be present between
intermediate and final products of which the structures are not
known-for example, as between an intermediate having a known structure
and a final product the structure of which is not known, or as between
an intermediate of unknown structure and a final product of unknown
structure. In order to satisfy unity in such cases, there shall be
sufficient evidence to lead one to conclude that the intermediate and
final products are technically closely interrelated as, for example,
when the intermediate contains the same essential element as the final
product or incorporates an essential element into the final product.

It is possible to accept in a single international application different
intermediate products used in different processes for the preparation of
the final product, provided that they have the same essential structural
element.

The intermediate and final products shall not be separated, in the
process leading from one to the other, by an intermediate which is not
new.

If the same international application claims different intermediates for
different structural parts of the final product, unity shall not be
regarded as being present between the intermediates.

If the intermediate and final products are families of compounds, each
intermediate compound shall correspond to a compound claimed in the
family of the final products. However, some of the final products may
have no corresponding compound in the family of the intermediate
products so that the two families need not be absolutely congruent.

As long as unity of invention can be recognized applying the above
interpretations, the fact that, besides the ability to be used to
produce final products, the intermediates also exhibit other possible
effects or activities shall not affect the decision on unity of
invention.

Rule 13.3 requires that the determination of the existence of unity of
invention be made without regard to whether the inventions are claimed
in separate claims or as alternatives within a single claim.

Rule 13.3 is not intended to constitute an encouragement to the use of
alternatives within a single claim, but is intended to clarify that the
criterion for the determination of unity of invention (namely, the
method contained in Rule 13.2) remains the same regardless of the form
of claim used.

Rule 13.3 does not prevent an International Searching or Preliminary
Examining Authority or an Office from objecting to alternatives being
contained within a single claim on the basis of considerations such as
clarity, the conciseness of claims or the claims fee system applicable
in that Authority or Office.

 ---SECTION---EXAMPLES CONCERNING UNITY OF INVENTION

The application of the principles of unity of invention is illustrated
by the following examples for guidance in particular cases.

---SECTION---I. CLAIMS IN  DIFFERENT CATEGORIES

1

A method of manufacturing chemical substance X.

2

Substance X.

3

The use of substance X as an insecticide.

Unity exists between claims 1, 2 and 3. The special technical feature
common to all the claims is substance X.

2

1

A process of manufacture comprising steps A and B.

2

Apparatus specifically designed for carrying out step A.

3

Apparatus specifically designed for carrying out step B.

Unity exists between claims 1 and 2 or between claims 1 and 3. There is
no unity between claims 2 and 3 since there exists no common special
technical feature between the two claims.

3

1

A process for painting an article in which the paint contains a new rust
inhibiting substance X including the steps of atomizing the paint using
compressed air, electrostatically charging the atomized paint using a
novel electrode arrangement A and directing the paint to the article.

2

A paint containing substance X.

3

An apparatus including electrode arrangement A.

Unity exists between claims 1 and 2 where the common special technical
feature is the paint containing substance X or between claims 1 and 3
where the common special technical feature is the electrode arrangement
A.

However, unity is lacking between claims 2 and 3 since there exists no
common special technical feature between them.

4

1

Use of a family of compounds X as insecticides.

2

Compound X1 belonging to family X.

Provided X1 has the insecticidal activity and the special technical
feature in claim 1 is the insecticidal use, unity is present.

5

1

A process for treating textiles comprising spraying the material with a
particular coating composition under special conditions (e.g., as to
temperature, irradiation).

2

A textile material coated according to the process of claim 1.

3

A spraying machine for use in the process of claim 1 and characterized
by a new nozzle arrangement providing a better distribution of the
composition being sprayed.

The process according to claim 1 imparts unexpected properties to the
product of claim 2.

The special technical feature in claim 1 is the use of special process
conditions corresponding to what is made necessary by the choice of the
particular coating. Unity exists between claims 1 and 2.

The spraying machine in claim 3 does not correspond to the above
identified special technical feature. Unity does not exist between claim
3 and claims 1 and 2.

6

1

A fuel burner with tangential fuel inlets into a mixing chamber.

2

A process for making a fuel burner including the step of forming
tangential fuel inlets into a mixing chamber.

3

A process for making a fuel burner including casting step A.

4

An apparatus for carrying out a process for making a fuel burner
including feature X resulting in the formation of tangential fuel
inlets.

5

An apparatus for carrying out a process for making a fuel burner
including a protective housing B.

6

A process of manufacturing carbon black including the step of
tangentially introducing fuel into a mixing chamber of a fuel burner.

Unity exists between claims 1, 2, 4, and 6. The special technical
feature common to all the claims is the tangential fuel inlets. Claims 3
and 5 lack unity with claims 1, 2, 4, and 6 since claims 3 and 5 do not
include the same or corresponding special technical feature as set forth
in claims 1, 2, 4, and 6. Claims 3 and 5 would also lack unity with one
another.

7

1

A high corrosion resistant and high strength ferritic stainless steel
strip consisting essentially of, in percent by weight: Ni=2.0-5.0;
Cr=15-19; Mo=1-2; and the balance Fe having a thickness of between 0.5
and 2.0 mm and a 0.2% yield strength in excess of 50 kg/mm squared.

2

A method of producing a high corrosion resistant and high strength
ferritic stainless steel strip consisting essentially of, in percent by
weight: Ni=2.0-5.0; Cr=15-19; Mo=1-2; and the balance Fe, comprising the
steps of: hot rolling to a thickness between 2.0 and 5.0 mm; annealing
the hot rolled strip at 800-1000C under substantially no oxidizing
conditions; cold rolling the strip to a thickness of between 0.5 and 2.0
mm; and final annealing the cold rolled strip at between 1120 and 1200C
for a period of 2-5 minutes.

Unity exists between product claim 1 and process claim 2. The special
technical feature in the product claim is the 0.2% yield strength in
excess of 50 kg/mm squared. The process steps in claim 2 inherently
produce a ferritic stainless steel strip with a 0.2% yield strength in
excess of 50 kg/mm squared. Even if this feature is not apparent from
the wording of claim 2, it is clearly disclosed in the description.
Therefore said process steps are the special technical feature which
correspond to the limitation in the product claim directed to the same
ferritic stainless steel with the claimed strength characteristics.

---SECTION---II. CLAIMS IN THE SAME CATEGORY

8

1

Plug characterized by feature A.

2

Socket characterized by corresponding feature A.

Feature A is a special technical feature which is included in both
claims 1 and 2 and therefore unity is present.

9

1

Transmitter provided with time axis expander for video signals.

2

Receiver provided with time axis compressor for video signals received.

3

Transmission equipment for video signals comprising a transmitter
provided with time axis expander for video signals and a receiver
provided with time axis compressor for video signals received.

The special technical features are in claim 1 the time axis expander,
and in claim 2 the time axis compressor, which are corresponding
technical features. Unity exists between claims 1 and 2. Claim 3
includes both special technical features and has unity with claims 1 and
2. The requirement for unity would still be met in the absence of the
combination claim (claim 3).

10

1

Conveyor belt with feature A.

2

Conveyor belt with feature B.

3

Conveyor belt with features A + B.

Feature A is a special technical feature and feature B is another
unrelated special technical feature. Unity exists between claims 1 and 3
or between claims 2 and 3, but not between claims 1 and 2.

11

1

Control circuit A for a d.c. motor.

2

Control circuit B for a d.c. motor.

3

An apparatus including a d.c. motor with control circuit A.

4

An apparatus including a d.c. motor with control circuit B.

Control circuit A is a special technical feature and control circuit B
is another unrelated special technical feature. Unity exists between
claims 1 and 3 or between claims 2 and 4, but not between claims 1 and 2
or 3 and 4.

12

1

A display with features A + B.

2

A display according to claim 1 with additional feature C.

3

A display with features A + B with additional feature D.

Unity exists between claims 1, 2, and 3. The special technical feature
common to all the claims is features A + B.

13

1

Filament A for a lamp.

2

Lamp B having filament A.

3

Searchlight provided with lamp B having filament A and a swivel
arrangement C.

Unity exists between claims 1, 2, and 3. The special technical feature
common to all the claims is the filament A.

14

1

A marking device for marking animals, comprising a disc-shaped element
with a stem extending normally therefrom, the tip of which is designed
to be driven through the skin of the animal to be marked, and a securing
disk element to be fastened to the protruding tip of the stem on the
other side of skin.

2

An apparatus for applying the marking device of claim 1, constructed as
a pneumatically actuated gun for driving the stem of the disc-shaped
element through the skin, and provided with a supporting surface adapted
for taking up a securing disc element, to be placed at the other side of
the body portion in question of the animal to be marked.

The special technical feature in claim 1 is the marking device having a
disc-shaped element with a stem and a securing disc element to be
fastened to the tip of the stem. The corresponding special technical
feature in claim 2 is the pneumatically actuated gun for driving the
marking device and having a supporting surface for the securing disc
element. Unity exists between claims 1 and 2.

15

1

Compound A.

2

An insecticide composition comprising compound A and a carrier.

Unity exists between claims 1 and 2. The special technical feature
common to all the claims is compound A.

16

1

An insecticide composition comprising compound A (consisting of a 1, a 2
...) and a carrier.

2

Compound a 1.

All compounds A are not claimed in the product claim 2 for reasons of
lack of novelty of some of them for instance. There is nevertheless
still unity between the subject matter of claims 1 and 2 provided a 1
has the insecticidal activity which is also the special technical
feature for compound A in claim 1.

17

1

Protein X

2

DNA sequence encoding protein X.

Expression of the DNA sequence in a host results in the production of a
protein which is determined by the DNA sequence. The protein and the DNA
sequence exhibit corresponding special technical features. Unity between
claims 1 and 2 is accepted.

---SECTION---III. MARKUSH PRACTICE

18

- common structure:

1

A compound of the formula:

[FIGURE]

wherein R1 is selected from the group consisting of phenyl, pyridyl,
thiazolyl, triazinyl, alkylthio, alkoxy, and methyl; R2-R4are methyl,
benzyl, or phenyl. The compounds are useful as pharmaceuticals for the
purpose of enhancing the capacity of the blood to absorb oxygen.

In this case the indolyl moiety is the significant structural element
which is shared by all of the alternatives. Since all the claimed
compounds are alleged to possess the same utility, unity is present.

19

- common structure:

1

A compound of the formula:

[FIGURE]

wherein R1 is selected from the group consisting of phenyl, pyridyl,
thiazolyl, triazinyl, alkylthio, alkoxy, and methyl; Z is selected from
the group consisting of oxygen (O), sulfur (S), imino (NH), and
methylene (-CH2-). The compounds are alleged to be useful as
pharmaceuticals for relieving lower back pain.

In this particular case the iminothioether group -N=C-SCH3 linked to a
six atom ring is the significant structural element which is shared by
all the alternatives. Thus, since all the claimed compounds are alleged
to possess the same use, unity would be present. A six membered
heterocyclic ring would not have been of sufficient similarity to allow
a Markush grouping exhibiting unity, absent some teaching of equivalence
in the prior art.

20

- common structure

1

A compound of the formula:

[FIGURE]

wherein R1 is methyl or phenyl, X and Z are selected from oxygen (O) and
sulfur (S).

The compounds are useful as pharmaceuticals and contain the
1,3-thiazolyl substituent which provides greater penetrability of
mammalian tissue which fact makes the compounds useful as relievers for
headaches and as topical anti-inflammatory agents.

All compounds share a common chemical structure, the thiazole ring and
the six atom heterocyclic compound bound to an imino group, which occupy
a large portion of their structure. A six-membered heterocyclic ring
would not have been of sufficient similarity to allow a Markush grouping
exhibiting unity, absent some teaching of equivalence in the prior art.

21

- common structure:

[FIGURE]

All of the above copolymers have in common a thermal degradation
resistance property, due to the reduced number of free COOH radicals by
esterification with X of the end COOH radicals which cause thermal
degradation. The chemical structures of the alternatives are considered
to be technically closely interrelated to one another. A grouping in one
claim is therefore allowed.

22

- common structure:

[FIGURE]

The compound obtained by esterifying the end COOH radical of known
polyhexamethyleneterephthalate with

[FIGURE] CH2O- has a thermal degradation resistant property, due to the
reduced number of free COOH radicals which cause thermal degradation. In
contrast, the compound obtained by esterifying the end COOH radical of
known polyhexamethyleneterephthalate with a vinyl compound containing a
CH2 = CH-

[FIGURE] CH2O- moiety serves as a raw material for a setting resin when
mixed with unsaturated monomer and cured (addition reaction).

All esters covered by the claim do not have a property or activity in
common. For example, the product obtained through esterification with
the "CH2= CH" vinyl compound does not have a thermal degradation
resistant property. The grouping in a single application is not allowed.

23

- No common structure:

1

A herbicidal composition consisting essentially of an effective amount
of the mixture of A 2,4-D(2,4-dichlorophenoxy acetic acid) and B a
second herbicide selected from the group consisting of copper sulfate,
sodium chlorate, ammonium sulfamate, sodium trichloroacetate,
dichloropropionic acid, 3-amino-2,5-dichlorobenzoic acid, diphenamid (an
amide), ioxynil (nitrile), dinoseb (phenol), trifluralin
(dinitroaniline), EPTC (thiocarbamate), and simazine (triazine) along
with an inert carrier or diluent.

The different components under B must be members of a recognized class
of compounds. Consequently in the present case a unity objection would
be raised because the members of B are not recognized as a class of
compounds, but, in fact, represent a plurality of classes which may be
identified as follows:

inorganic salts: copper sulfate sodium chlorate ammonium sulfamate

organic salts and carboxylic acids: sodium trichloroacetate
dichloropropionic acid 3-amino-2,5-dichlorobenzoic acid

amides: diphenamid

nitriles: ioxynil

phenols: dinoseb

amines: trifluralin

heterocyclic: simazine

24

Claim 1: Catalyst for vapor phase oxidation of hydrocarbons, which
consists of (X) or (X + a).

In this example (X) oxidizes RCH3 into RCH2OH and (X+a) oxidizes RCH3
further into RCOOH.

Both catalysts share a common component and a common activity as
oxidation catalyst for RCH3 With (X+a) the oxidation is more complete
and goes until the carboxylic acid is formed but the activity still
remains the same.

A Markush grouping is acceptable.

---SECTION---IV. INTERMEDIATE/FINAL PRODUCTS

25

1

2

[FIGURE]

The chemical structures of the intermediate and final product are
technically closely interrelated. The essential structural element
incorporated into the final product is:

[FIGURE]

Therefore, unity exists between claims 1 and 2.

26

1

[FIGURE]

2

[FIGURE]

(II) is described as an intermediate to make (I). The closure mechanism
is one well known in the art. Though the basic structures of compound
(I) (final product) and compound (II) (intermediate) differ
considerably, compound (II) is an open ring precursor to compound (I).
Both compounds share a common essential structural element which is the
linkage comprising the two phenyl rings and the triazole ring. The
chemical structures of the two compounds are therefore considered to be
technically closely interrelated.

The example therefore satisfies the requirement for unity of invention.

27

Claim 1: Amorphous polymer A (intermediate).

Claim 2: Crystalline polymer A (final product).

In this example a film of the amorphous polymer A is stretched to make
it crystalline. Here unity exists because there is an intermediate final
product relation in that amorphous polymer A is used as a starting
product to prepare crystalline polymer A.

For purposes of further illustration, assume that the polymer A in this
example is polyisoprene. Here the intermediate, amorphous polyisoprene,
and the final product, crystalline polyisoprene, have the same chemical
structure.

28

1

Polymeric compound useful as fiber material identified by the following
general formula:

[repeating unit (X)]

[FIGURE]

2

Compound identified by the following general formula:

(useful as intermediate for polymeric compound I)

[FIGURE]

(primary condensation product)

The two inventions are in an intermediate and final product
relationship.

Substance (II) is a raw material for substance (I).

Meanwhile, both compounds share an essential structural element
(repeating unit (X)) and are technically closely interrelated. The
intermediate and final products therefore satisfy the requirements for
unity.

29

1

Novel compound having structure A (Intermediate).

2

Product prepared by reacting A with a substance X (Final Product).

30

1

Reaction product of A and B (Intermediate).

2

Product prepared by reacting the reaction product of A and B with
substances X and Y (Final Product).

In examples 29 and 30 the chemical structure(s) of the intermediate
and/or the final product is not known. In (29) the structure of the
product of claim 2 (the final product) is not known. In (30) the
structures of the products of claim 1 (the intermediate) and claim 2
(the final product) are unknown. Unity exists if there is evidence which
would lead one to conclude that the characteristic of the final product
which is the inventive feature in the case is due to the intermediate.
For example, the purpose for using the intermediates in (29) or (30) is
to modify certain properties of the final product. The evidence may be
in the form of test data in the specification showing the effect of the
intermediate on the final product. If no such evidence exists then there
is no unity on the basis of an intermediate-final product relationship.

C

STANDARD FOR THE PRESENTATION OF NUCLEOTIDE AND AMINO ACID SEQUENCE
LISTINGS IN INTERNATIONAL PATENT APPLICATIONS UNDER THE PCT

Introduction

This Standard has been elaborated so as to provide standardization of
the presentation of nucleotide and amino acid sequence listings in
international patent applications. The Standard is intended to allow the
applicant to draw up a single sequence listing which is acceptable to
all receiving Offices, International Searching and Preliminary Examining
Authorities for the purposes of the international phase, and to all
designated and elected Offices for the purposes of the national phase.
It is intended to enhance the accuracy and quality of presentations of
nucleotide and amino acid sequences given in international applications,
to make for easier presentation and dissemination of sequences for the
benefit of applicants, the public and examiners, to facilitate searching
of sequence data and to allow the exchange of sequence data in
electronic form and the introduction of sequence data onto computerized
databases.

Definitions

For the purposes of this Standard:

the expression "sequence listing" means a part of the description of the
application as filed or a document filed subsequently to the
application, which gives a detailed disclosure of the nucleotide and/or
amino acid sequences and other available information;

sequences which are included are any unbranched sequences of four or
more amino acids or unbranched sequences of ten or more nucleotides.
Branched sequences, sequences with fewer than four specifically defined
nucleotides or amino acids as well as sequences comprising nucleotides
or amino acids other than those listed in Appendix 2, Tables 1, 2, 3 and
4, are specifically excluded from this definition;

"nucleotides" embrace only those nucleotides that can be represented
using the symbols set forth in Appendix 2, Table 1. Modifications, for
example, methylated bases, may be described as set forth in Appendix 2,
Table 2, but shall not be shown explicitly in the nucleotide sequence;

"amino acids" are those L-amino acids commonly found in naturally
occurring proteins and are listed in Appendix 2, Table 3. Those amino
acid sequences containing at least one D-amino acid are not intended to
be embraced by this definition. Any amino acid sequence that contains
post-translationally modified amino acids may be described as the amino
acid sequence that is initially translated using the symbols shown in
Appendix 2, Table 3, with the modified positions, for example,
hydroxylations or glycosylations, being described as set forth in
Appendix 2, Table 4, but these modifications shall not be shown
explicitly in the amino acid sequence. Any peptide or protein that can
be expressed as a sequence using the symbols in Appendix 2, Table 3, in
conjunction with a description elsewhere to describe, for example,
abnormal linkages, cross-links (for example, disulfide bridge) and end
caps, non-peptidyl bonds, etc., is embraced by this definition;

"sequence identifier" is a unique integer that corresponds to the SEQ ID
NO assigned to each sequence in the listing;

"numeric identifier" is a three-digit number which represents a specific
data element;

"language-neutral vocabulary" is a controlled vocabulary used in the
sequence listing that represents scientific terms as prescribed by
sequence database providers (including scientific names, qualifiers and
their controlled-vocabulary values, the symbols appearing in Appendix 2,
Tables 1, 2, 3 and 4, and the feature keys appearing in Appendix 2,
Tables 5 and 6;

"competent Authority" is the International Searching Authority that is
to carry out the international search on the international application,
or the International Preliminary Examining Authority that is to carry
out the international preliminary examination on the international
application, or the designated/elected Office before which the
processing of the international application has started.

Sequence Listing

The sequence listing as defined in paragraph 2(i) shall, where it is
filed together with the application, be placed at the end of the
application. This part shall be entitled "Sequence Listing", begin on a
new page and preferably have independent page numbering. The sequence
listing forms an integral part of the description; it is therefore
unnecessary, subject to paragraph 36, to describe the sequences
elsewhere in the description.

Where the sequence listing as defined in paragraph 2(i) is not contained
in the application as filed but is a separate document furnished
subsequently to the filing of the application (see paragraph 37), it
shall be entitled "Sequence Listing" and shall have independent page
numbering. The original numbering of the sequences (see paragraph 5) in
the application as filed shall be maintained in the subsequently
furnished sequence listing.

Each sequence shall be assigned a separate sequence identifier. The
sequence identifiers shall begin with 1 and increase sequentially by
integers. If no sequence is present for a sequence identifier, the code
000 should appear under numeric identifier &lt;400&gt;, beginning on the
next line following the SEQ ID NO. The response for numeric identifier
&lt;160&gt; shall include the total number of SEQ ID NOs, whether
followed by a sequence or by the code 000.

In the description, claims or drawings of the application, the sequences
represented in the sequence listing shall be referred to by the sequence
identifier and preceded by "SEQ ID NO:".

Nucleotide and amino acid sequences should be represented by at least
one of the following three possibilities:

a pure nucleotide sequence;

a pure amino acid sequence;

a nucleotide sequence together with its corresponding amino acid
sequence.

For those sequences disclosed in the format specified in option (iii),
above, the amino acid sequence must be disclosed separately in the
sequence listing as a pure amino acid sequence with a separate integer
sequence identifier.

Nucleotide Sequences

Symbols to Be Used

A nucleotide sequence shall be presented only by a single strand, in the
5'-end to 3'-end direction from left to right. The terms 3' and 5' shall
not be represented in the sequence.

The bases of a nucleotide sequence shall be represented using the
one-letter code for nucleotide sequence characters. Only lower case
letters in conformity with the list given in Appendix 2, Table 1, shall
be used.

Modified bases shall be represented as the corresponding unmodified
bases or as "n" in the sequence itself if the modified base is one of
those listed in Appendix 2, Table 2, and the modification shall be
further described in the feature section of the sequence listing, using
the codes given in Appendix 2, Table 2. These codes may be used in the
description or the feature section of the sequence listing but not in
the sequence itself (see also paragraph 32). The symbol "n" is the
equivalent of only one unknown or modified nucleotide.

Format to Be Used

A nucleotide sequence shall be listed with a maximum of 60 bases per
line, with a space between each group of 10 bases.

The bases of a nucleotide sequence (including introns) shall be listed
in groups of 10 bases, except in the coding parts of the sequence.
Leftover bases, fewer than 10 in number at the end of non-coding parts
of a sequence, should be grouped together and separated from adjacent
groups by a space.

The bases of the coding parts of a nucleotide sequence shall be listed
as triplets (codons).

The enumeration of the nucleotide shall start at the first base of the
sequence with number 1. It shall be continuous through the whole
sequence in the direction 5' to 3'. It shall be marked in the right
margin, next to the line containing the one-letter codes for the bases,
and giving the number of the last base of that line. The enumeration
method for nucleotide sequences set forth above remains applicable to
nucleotide sequences that are circular in configuration, with the
exception that the designation of the first nucleotide of the sequence
may be made at the option of the applicant.

A nucleotide sequence that is made up of one or more non-contiguous
segments of a larger sequence or of segments from different sequences
shall be numbered as a separate sequence, with a separate sequence
identifier. A sequence with a gap or gaps shall be numbered as a
plurality of separate sequences with separate sequence identifiers, with
the number of separate sequences being equal in number to the number of
continuous strings of sequence data.

Amino Acid Sequences

Symbols to Be Used

The amino acids in a protein or peptide sequence shall be listed in the
amino to carboxy direction from left to right. The amino and carboxy
groups shall not be represented in the sequence.

The amino acids shall be represented using the three-letter code with
the first letter as a capital and shall conform to the list given in
Appendix 2, Table 3. An amino acid sequence that contains a blank or
internal terminator symbols (for example, "Ter" or "*" or ".") may not
be represented as a single amino acid sequence, but shall be presented
as separate amino acid sequences (see paragraph 22).

Modified and unusual amino acids shall be represented as the
corresponding unmodified amino acids or as "Xaa" in the sequence itself
if the modified amino acid is one of those listed in Appendix 2, Table
4, and the modification shall be further described in the feature
section of the sequence listing, using the codes given in Appendix 2,
Table 4. These codes may be used in the description or the feature
section of the sequence listing but not in the sequence itself (see also
paragraph 32). The symbol "Xaa" is the equivalent of only one unknown or
modified amino acid.

Format to Be Used

A protein or peptide sequence shall be listed with a maximum of 16 amino
acids per line, with a space provided between each amino acid.

Amino acids corresponding to the codons in the coding parts of a
nucleotide sequence shall be placed immediately under the corresponding
codons. Where a codon is split by an intron, the amino acid symbol
should be given below the portion of the codon containing two
nucleotides.

The enumeration of amino acids shall start at the first amino acid of
the sequence, with number 1. Optionally, the amino acids preceding the
mature protein, for example pre-sequences, pro-sequences,
pre-pro-sequences and signal sequences, when present, may have negative
numbers, counting backwards starting with the amino acid next to number
1. Zero (0) is not used when the numbering of amino acids uses negative
numbers to distinguish the mature protein. It shall be marked under the
sequence every five amino acids. The enumeration method for amino acid
sequences set forth above remains applicable for amino acid sequences
that are circular in configuration, with the exception that the
designation of the first amino acid of the sequence may be made at the
option of the applicant.

An amino acid sequence that is made up of one or more non-contiguous
segments of a larger sequence or of segments from different sequences
shall be numbered as a separate sequence, with a separate sequence
identifier. A sequence with a gap or gaps shall be numbered as a
plurality of separate sequences with separate sequence identifiers, with
the number of separate sequences being equal in number to the number of
continuous strings of sequence data.

Other Available Information in the Sequence Listing

The order of the items of information in the sequence listings shall
follow the order in which those items are listed in the list of numeric
identifiers of data elements as defined in Appendix 1.

Only numeric identifiers of data elements as defined in Appendix 1 shall
be used for the presentation of the items of information in the sequence
listing. The corresponding numeric identifier descriptions shall not be
used. The provided information shall follow immediately after the
numeric identifier while only those numeric identifiers for which
information is given need appear on the sequence listing. Two exceptions
to this requirement are numeric identifiers &lt;220&gt; and &lt;300&gt;,
which serve as headers for "Feature" and "Publication Information,"
respectively, and are associated with information in numeric identifiers
&lt;221&gt; to &lt;223&gt; and &lt;301&gt; to &lt;313&gt;, respectively.
When feature and publication information is provided in the sequence
listing under those numeric identifiers, numeric identifiers &lt;220&gt;
and &lt;300&gt;, respectively, should be included, but left blank.
Generally, a blank line shall be inserted between numeric identifiers
when the digit in the first or second position of the numeric identifier
changes. An exception to this general rule is that no blank line should
appear preceding numeric identifier &lt;310&gt;. Additionally, a blank
line shall precede any repeated numeric identifier.

Mandatory Data Elements

The sequence listing shall include, in addition to and immediately
preceding the actual nucleotide and/or amino acid sequence, the
following items of information defined in Appendix 1 (mandatory data
elements):

&lt;110&gt;

Applicant name

&lt;120&gt;

Title of invention

&lt;160&gt;

Number of SEQ ID NOs

&lt;210&gt;

SEQ ID NO: x

&lt;211&gt;

Length

&lt;212&gt;

Type

&lt;213&gt;

Organism

&lt;400&gt;

Sequence

Where the name of the applicant (numeric identifier &lt;110&gt;) is
written in characters other than those of the Latin alphabet, it shall
also be indicated in characters of the Latin alphabet either as a mere
transliteration or through translation into English.

The data elements, except those under numeric identifiers &lt;110&gt;,
&lt;120&gt; and &lt;160&gt;, shall be repeated for each sequence
included in the sequence listing. Only the data elements under numeric
identifiers &lt;210&gt; and &lt;400&gt; are mandatory if no sequence is
present for a sequence identifier (see paragraph 5, above, and SEQ ID
NO: 4 in the example depicted in Appendix 3 of this Standard).

In addition to the data elements identified in paragraph 25, above, when
a sequence listing is filed at the same time as the application to which
it pertains or at any time prior to the assignment of an application
number, the following data element shall be included in the sequence
listing:

&lt;130&gt;

File reference

In addition to the data elements identified in paragraph 25, above, when
a sequence listing is filed in response to a request from a competent
Authority or at any time following the assignment of an application
number, the following data elements shall be included in the sequence
listing:

&lt;140&gt;

Current patent application

&lt;141&gt;

Current filing date

In addition to the data elements identified in paragraph 25, above, when
a sequence listing is filed relating to an application which claims the
priority of an earlier application, the following data elements shall be
included in the sequence listing:

&lt;150&gt;

Earlier patent application

&lt;151&gt;

Earlier application filing date

If "n" or "Xaa" or a modified base or modified/unusual L-amino acid is
used in the sequence, the following data elements are mandatory:

&lt;220&gt;

Feature

&lt;221&gt;

Name/key

&lt;222&gt;

Location

&lt;223&gt;

Other information

If the organism (numeric identifier &lt;213&gt;) is "Artificial
Sequence" or "Unknown," the following data elements are mandatory:

&lt;220&gt;

Feature

&lt;223&gt;

Other information

Optional Data Elements

All data elements defined in Appendix 1, not mentioned in paragraphs 25
to 30, above, are optional (optional data elements).

Presentation of Features

When features of sequences are presented (that is, numeric identifier
&lt;220&gt;), they shall be described by the "feature keys" set out in
Appendix 2, Tables 5 and 6.

[FIGURE]

Free Text

"Free text" is a wording describing characteristics of the sequence
under numeric identifier &lt;223&gt; (Other information) which does not
use language-neutral vocabulary as referred to in paragraph 2(vii).

The use of free text shall be limited to a few short terms indispensable
for the understanding of the sequence. It shall not exceed four lines
with a maximum of 65 characters per line for each given data element,
when written in English. Any further information shall be included in
the main part of the description in the language thereof.

Any free text should preferably be in the English language.

Where the sequence listing part of the description contains free text,
any such free text shall be repeated in the main part of the description
in the language thereof. It is recommended that the free text in the
language of the main part of the description be put in a specific
section of the description called "Sequence Listing Free Text."

Subsequently Furnished Sequence Listing

Any sequence listing which is not contained in the application as filed
but which is furnished subsequently shall not go beyond the disclosure
in the application as filed and shall be accompanied by a statement to
that effect. This means that a sequence listing furnished subsequently
to the filing of the application shall contain only those sequences that
were disclosed in the application as filed.

Any sequence listing not contained in the application as filed does not
form part of the application. However, the provisions of PCT Rules 13
ter, 26.3 and 91 and PCT Article 34 would apply, so that it may be
possible, subject to the applicable provisions, for a sequence listing
contained in the application as filed to be corrected under PCT Rules 13
ter or 26.3, rectified under PCT Rule 91 (in the case of an obvious
error), or amended under PCT Article 34, or for a sequence listing to be
submitted under PCT Article 34 as an amendment to the application.

Computer Readable Form of the Sequence Listing

A copy of the sequence listing shall also be submitted in computer
readable form, in addition to the sequence listing as contained in the
application, whenever this is required by the competent Authority.

Any sequence listing in computer readable form submitted in addition to
the written sequence listing shall be identical to the written sequence
listing and shall be accompanied by a statement that "the information
recorded in computer readable form is identical to the written sequence
listing."

The entire printable copy of the sequence listing shall be contained
within one electronic file preferably on a single diskette or any other
electronic medium that is acceptable to the competent Authority. The
file recorded on the diskette or any other electronic medium that is
acceptable to the competent Authority shall be encoded using IBM

[FIGURE] Code Page 437, IBM Code Page 932

[FIGURE] or a compatible code page. A compatible code page, as would be
required for, for example, Japanese, Chinese, Cyrillic, Arabic, Greek or
Hebrew characters, is one that assigns the Roman alphabet and numerals
to the same hexadecimal positions as do the specified code pages.

The computer readable form shall preferably be created by dedicated
software such as PatentIn or other custom computer programs; it may be
created by any means, as long as the sequence listing on a submitted
diskette or any other electronic medium that is acceptable to the
competent Authority is readable under a Personal Computer Operating
system that is acceptable to the competent Authority.

File compression is acceptable when using diskette media, so long as the
compressed file is in a self-extracting format that will decompress on a
Personal Computer Operating system that is acceptable to the competent
Authority.

The diskette or any other electronic medium that is acceptable to the
competent Authority shall have a label permanently affixed thereto on
which has been hand-printed, in block capitals or typed, the name of the
applicant, the title of the invention, a reference number, the date on
which the data were recorded, the computer operating system and the name
of the competent Authority.

If the diskette or any other electronic medium that is acceptable to the
competent Authority is submitted after the date of filing of an
application, the labels shall also include the filing date of the
application and the application number.

Any correction of the written sequence listing which is submitted under
PCT Rules 13 ter.1(a)(i) or 26.3, any rectification of an obvious error
in the written sequence listing which is submitted under PCT Rule 91, or
any amendment which includes a written sequence listing and which is
submitted under PCT Article 34, shall be accompanied by a computer
readable form of the sequence listing including any such correction,
rectification or amendment.

Appendices

Appendix 1: Numeric Identifiers

Appendix 2: Nucleotide and Amino Acid Symbols and Feature Table

Table 1: List of Nucleotides

Table 2: List of Modified Nucleotides

Table 3: List of Amino Acids

Table 4: List of Modified and Unusual Amino Acids

Table 5: List of Feature Keys Related to Nucleotide Sequences

Table 6: List of Feature Keys Related to Protein Sequences

Appendix 3: Specimen Sequence Listing

---SECTION---1 Numeric Identifiers

Only numeric identifiers as defined below may be used in sequence
listings submitted in applications. The text of the data element
headings given below shall not be included in the sequence listings.

Numeric identifiers of mandatory data elements, that is, data elements
which must be included in all sequence listings (see paragraph 25 of
this Standard: items 110, 120, 160, 210, 211, 212, 213 and 400) and
numeric identifiers of data elements which must be included in
circumstances specified in this Standard (see paragraphs 26, 27, 28, 29
and 30 of this Standard: items 130, 140, 141, 150 and 151, and 220 to
223) are marked by the symbol "M."

Numeric identifiers of optional data elements (see paragraph 31 of this
Standard) are marked by the symbol "O."

Numeric Identifier

Numeric Identifier Description

Mandatory (M) or Optional (O)

Comment

&lt;110&gt;

Applicant name

M

where the name of the applicant is written in characters other than
those of the Latin alphabet, the same shall also be indicated in
characters of the Latin alphabet either as a mere transliteration or
through translation into English

&lt;120&gt;

Title of Invention

M

&lt;130&gt;

File Reference

M, in the circumstances specified in paragraph 26 of this Standard

see paragraph 26 of this Standard

&lt;140&gt;

Current patent application

M, in the circumstances specified in paragraph 27 of this Standard

see paragraph 27 of this Standard; the current patent application shall
be identified, in the following order, by the two-letter code indicated
in accordance with WIPO Standard ST.3 and the application number (in the
format used by the industrial property Office with which the current
patent application is filed) or, for an international application, by
the international application number

&lt;141&gt;

Current filing date

M, in the circumstances specified in paragraph 27 of this Standard

see paragraph 27 of this Standard; the date shall be indicated in
accordance with WIPO Standard ST.2 (CCYY MM DD)

&lt;150&gt;

Earlier patent application

M, in the circumstances specified in paragraph 28 of this Standard

see paragraph 28 of this Standard; the earlier patent application shall
be identified, in the following order, by the two-letter code indicated
in accordance with WIPO Standard ST.3 and the application number (in the
format used by the industrial property Office with which the earlier
patent application was filed) or, for an international application, by
the international application number

&lt;151&gt;

Earlier application filing date

M, in the circumstances specified in paragraph 28 of this Standard

see paragraph 28 of this Standard; the date shall be indicated in
accordance with WIPO Standard ST.2 (CCYY MM DD)

&lt;160&gt;

Number of SEQ ID NOs

M

&lt;170&gt;

Software

O

&lt;210&gt;

Information for SEQ ID NO: x

M

response shall be an integer representing the SEQ ID NO shown

[Annex C, Appendix 1, continued]

&lt;211&gt;

Length

M

sequence length expressed in number of base pairs or amino acids

&lt;212&gt;

Type

M

type of molecule sequenced in SEQ ID NO: x, either DNA, RNA or PRT; if a
nucleotide sequence contains both DNA and RNA fragments, the value shall
be "DNA"; in addition, the combined DNA/RNA molecule shall be further
described in the &lt;220&gt; to &lt;223&gt; feature section

&lt;213&gt;

Organism

M

Genus Species (that is, scientific name) or "Artificial Sequence" or
"Unknown"

&lt;220&gt;

Feature

M, in the circumstances specified in paragraph 29 and 30 of this
Standard

leave blank; see paragraphs 29 and 30 of this Standard; description of
points of biological significance in the sequence in SEQ ID NO: x) (may
be repeated depending on the number of features indicated)

&lt;221&gt;

Name/key

M in the circumstances specified in paragraph 29 of this Standard

see paragraph 29 of this Standard; only those keys as described in Table
5 or 6 of Appendix 2 shall be used

&lt;222&gt;

Location

M, in the circumstances specified in paragraph 29 of this Standard

see paragraph 29 of this Standard; - from (number of first base/amino
acid in the feature) - to (number of last base/amino acid in the
feature) - base pairs (numbers refer to positions of base pairs in a
nucleotide sequence) - amino acids (numbers refer to positions of amino
acid residues in an amino acid sequence) - whether feature is located on
the complementary strand to that filed in the sequence listing

&lt;223&gt;

Other information:

M, in the circumstances specified in paragraphs 29 and 30 of this
Standard

see paragraphs 29 and 30 of this Standard; any other relevant
information, using language neutral vocabulary, or free text (preferably
in English); any free text is to be repeated in the main part of the
description in the language thereof (see paragraph 36 of this Standard);
where any modified base or modified/unusual L-amino acid appearing in
Appendix 2, Tables 2 and 4, is in the sequence, the symbol associated
with that base or amino acid from Appendix 2, Tables 2 and 4, should be
used

&lt;300&gt;

Publication information

O

leave blank; repeat section for each relevant publication

&lt;301&gt;

Authors

O

&lt;302&gt;

Title

O

title of publication

&lt;303&gt;

Journal

O

journal name in which data published

&lt;304&gt;

Volume

O

journal volume in which data published

&lt;305&gt;

Issue

O

journal issue number in which data published

&lt;306&gt;

Pages

O

journal page numbers on which data published

&lt;307&gt;

Date

O

journal date on which data published; if possible, the date shall be
indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)

&lt;308&gt;

Database accession number

O

accession number assigned by database including database name

&lt;309&gt;

Database entry date

O

date of entry in database; the date shall be indicated in accordance
with WIPO Standard ST.2 (CCYY MM DD)

[Annex C, Appendix 1, continued]

&lt;310&gt;

Document number

O

document number, for patent type citations only; the full document shall
specify, in the following order, the two-letter code indicated in
accordance with WIPO Standard ST.3, the publication number indicated in
accordance with WIPO Standard ST.6, and the kind-of-document code
indicated in accordance with WIPO Standard ST.16

&lt;311&gt;

Filing date

O

document filing date, for patent-type citations only; the date shall be
indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)

&lt;312&gt;

Publication date

O

document publication date; for patent-type citations only; the date
shall be indicated in accordance with WIPO Standard ST.2 (CCYY MM DD)

&lt;313&gt;

Relevant residues in SEQ ID NO: x: from to

O

&lt;400&gt;

Sequence

M

SEQ ID NO: x should follow the numeric identifier and should appear on
the line preceding the sequence (see Appendix 3)

---SECTION---2 Nucleotide and Amino Acid Symbols and Feature Table

Table 1: List of Nucleotides

Symbol

Meaning

Origin of designation

a

a

adenine

g

g

guanine

c

c

cytosine

t

t

thymine

u

u

uracil

r

g or a

purine

y

t/u or c

pyrimidine

m

a or c

amino

k

g or t/u

keto

s

g or c

strong interactions 3H-bonds

w

a or t/u

weak interactions 2H-bonds

b

g or c or t/u

not a

d

a or g or t/u

not c

h

a or c or t/u

not g

v

a or g or c

not t, not u

n

a or g or c or t/u, unknown, or other

any

Table 2: List of Modified Nucleotides

Symbol

Meaning

ac4c

4-acetylcytidine

chm5u

5-(carboxyhydroxymethyl)uridine

cm

2 4-O-methylcytidine

cmnm5s2u

5-carboxymethylaminomethyl-2-thiouridine

cmnm5u

5-carboxymethylaminomethyluridine

d

dihydrouridine

fm

24-O-methylpseudouridine

gal q

beta, D-galactosylqueuosine

gm

24-O-methylguanosine

i

inosine

i6a

N6-isopentenyladenosine

m1a

1-methyladenosine

m1f

1-methylpseudouridine

m1g

1-methylguanosine

m1i

1-methylinosine

m22g

2,2-dimethylguanosine

m2a

2-methyladenosine

m2g

2-methylguanosine

m3c

3-methylcytidine

m5c

5-methylcytidine

m6a

N6-methyladenosine

m7g

7-methylguanosine

mam5u

5-methylaminomethyluridine

mam5s2u

5-methoxyaminomethyl-2-thiouridine

man q

beta, D-mannosylqueuosine

mcm5s2u

5-methoxycarbonylmethyl-2-thiouridine

mcm5u

5-methoxycarbonylmethyluridine

mo5u

5-methoxyuridine

ms2i6a

2-methylthio-N6-isopentenyladenosine

ms2t6a

N-((9-beta-D-ribofuranosyl-2-methylthiopurine-6-yl)carbamoyl)threonine

mt6a

N-((9-beta-D-ribofuranosylpurine-6-yl)N-methylcarbamoyl)threonine

mv

uridine-5-oxyacetic acid-methylester

o5u

uridine-5-oxyacetic acid

Symbol

Meaning

osyw

wybutoxosine

p

pseudouridine

q

queuosine

s2c

2-thiocytidine

s2t

5-methyl-2-thiouridine

s2u

2-thiouridine

s4u

4-thiouridine

t

5-methyluridine

t6a

N-((9-beta-D-ribofuranosylpurine-6-yl)-carbamoyl)threonine

tm

2 4-O-methyl-5-methyluridine

um

24-O-methyluridine

yw

wybutosine

x

3-(3-amino-3-carboxy-propyl)uridine, (acp3)u

Table 3: List of Amino Acids

Symbol

Meaning

Ala

Alanine

Cys

Cysteine

Asp

Aspartic Acid

Glu

Glutamic Acid

Phe

Phenylalanine

Gly

Glycine

His

Histidine

Ile

Isoleucine

Lys

Lysine

Leu

Leucine

Met

Methionine

Asn

Asparagine

Pro

Proline

Gln

Glutamine

Arg

Arginine

Ser

Serine

Thr

Threonine

Val

Valine

Trp

Tryptophan

Tyr

Tyrosine

Asx

Asp or Asn

Glx

Glu or Gln

Xaa

unknown or other

Table 4: List of Modified and Unusual Amino Acids

Symbol

Meaning

Aad

2-Aminoadipic acid

bAad

3-Aminoadipic acid

bAla

beta-Alanine, beta-Aminopropionic acid

Abu

2-Aminobutyric acid

4Abu

4-Aminobutyric acid, piperidinic acid

Acp

6-Aminocaproic acid

Ahe

2-Aminoheptanoic acid

Aib

2-Aminoisobutyric acid

bAib

3-Aminoisobutyric acid

Apm

2-Aminopimelic acid

Dbu

2,4 Diaminobutyric acid

Des

Desmosine

Dpm

2,24 -Diaminopimelic acid

Dpr

2,3-Diaminopropionic acid

EtGly

N-Ethylglycine

EtAsn

N-Ethylasparagine

Hyl

Hydroxylysine

aHyl

allo-Hydroxylysine

3Hyp

3-Hydroxyproline

4Hyp

4-Hydroxyproline

Ide

Isodesmosine

aIle

allo-Isoleucine

MeGly

N-Methylglycine, sarcosine

MeIle

N-Methylisoleucine

MeLys

6-N-Methyllysine

MeVal

N-Methylvaline

Nva

Norvaline

Nle

Norleucine

Orn

Ornithine

Table 5: List of Feature Keys Related to Nucleotide Sequences

Key

Description

allele

a related individual or strain contains stable, alternative forms of the
same gene which differs from the presented sequence at this location
(and perhaps others)

attenuator

(1) region of DNA at which regulation of termination of transcription
occurs, which controls the expression of some bacterial operons; (2)
sequence segment located between the promoter and the first structural
gene that causes partial termination of transcription

C_region

constant region of immunoglobulin light and heavy chains, and T-cell
receptor alpha, beta, and gamma chains; includes one or more exons
depending on the particular chain

CAAT_signal

CAAT box; part of a conserved sequence located about 75 bp up-stream of
the start point of eukaryotic transcription units which may be involved
in RNA polymerase binding; consensus=GG (C or T) CAATCT

CDS

coding sequence; sequence of nucleotides that corresponds with the
sequence of amino acids in a protein (location includes stop codon);
feature includes amino acid conceptual translation

conflict

independent determinations of the "same" sequence differ at this site or
region

D-loop

displacement loop; a region within mitochondrial DNA in which a short
stretch of RNA is paired with one strand of DNA, displacing the original
partner DNA strand in this region; also used to describe the
displacement of a region of one strand of duplex DNA by a single
stranded invader in the reaction catalyzed by RecA protein

D-segment

diversity segment of immunoglobulin heavy chain, and T-cell receptor
beta chain

enhancer

a cis-acting sequence that increases the utilization of (some)
eukaryotic promoters, and can function in either orientation and in any
location (upstream or downstream) relative to the promoter

exon

region of genome that codes for portion of spliced mRNA; may contain
54UTR, all CDSs, and 34UTR

GC_signal

GC box; a conserved GC-rich region located upstream of the start point
of eukaryotic transcription units which may occur in multiple copies or
in either orientation; consensus=GGGCGG

gene

region of biological interest identified as a gene and for which a name
has been assigned

iDNA

intervening DNA; DNA which is eliminated through any of several kinds of
recombination

intron

a segment of DNA that is transcribed, but removed from within the
transcript by splicing together the sequences (exons) on either side of
it

J_segment

joining segment of immunoglobulin light and heavy chains, and T-cell
receptor alpha, beta, and gamma chains

Key

Description

LTR

long terminal repeat, a sequence directly repeated at both ends of a
defined sequence, of the sort typically found in retroviruses

mat_peptide

mature peptide or protein coding sequence; coding sequence for the
mature or final peptide or protein product following post-translational
modification; the location does not include the stop codon (unlike the
corresponding CDS)

misc_binding

site in nucleic acid which covalently or non-covalently binds another
moiety that cannot be described by any other Binding key (primer_bind or
protein_bind)

misc_difference

feature sequence is different from that presented in the entry and
cannot be described by any other Difference key (conflict, unsure,
old_sequence, mutation, variation, allele, or modified_base)

misc_feature

region of biological interest which cannot be described by any other
feature key; a new or rare feature

misc_recomb

site of any generalized, site-specific or replicative recombination
event where there is a breakage and reunion of duplex DNA that cannot be
described by other recombination keys (iDNA and virion) or qualifiers of
source key (/insertion_seq, /transposon, /proviral)

misc_RNA

any transcript or RNA product that cannot be defined by other RNA keys
(prim_transcript, precursor_RNA, mRNA, 5 4clip, 34clip, 54UTR, 34UTR,
exon, CDS, sig_peptide, transit_peptide, mat_peptide, intron,
polyA_site, rRNA, tRNA, scRNA, and snRNA)

misc_signal

any region containing a signal controlling or altering gene function or
expression that cannot be described by other Signal keys (promoter,
CAAT_signal, TATA_signal, -35_signal, -10_signal, GC_signal, RBS,
polyA_signal, enhancer, attenuator, terminator, and rep_origin)

misc_structure

any secondary or tertiary structure or conformation that cannot be
described by other Structure keys (stem_loop and D-loop)

modified_base

the indicated nucleotide is a modified nucleotide and should be
substituted for by the indicated molecule (given in the mod_base
qualifier value)

mRNA

messenger RNA; includes 54 untranslated region (54UTR), coding sequences
(CDS, exon) and 34 untranslated region (34UTR)

mutation

a related strain has an abrupt, inheritable change in the sequence at
this location

N_region

extra nucleotides inserted between rearranged immunoglobulin segments

old_sequence

the presented sequence revises a previous version of the sequence at
this location

polyA_signal

recognition region necessary for endonuclease cleavage of an RNA
transcript that is followed by polyadenylation; consensus=AATAAA

polyA_site

site on an RNA transcript to which will be added adenine residues by
post-transcriptional polyadenylation

precursor_RNA

any RNA species that is not yet the mature RNA product; may include 54
clipped region (54clip), 54 untranslated region (54UTR), coding
sequences (CDS, exon), intervening sequences (intron), 34 untranslated
region (34UTR), and 34 clipped region (34clip)

prim_transcript

primary (initial, unprocessed) transcript; includes 54 clipped region
(54clip), 54 untranslated region (54UTR), coding sequences (CDS, exon),
intervening sequences (intron), 34 untranslated region (34UTR), and 34
clipped region (34clip)

Key

Description

primer_bind

non-covalent primer binding site for initiation of replication,
transcription, or reverse transcription; includes site(s) for synthetic,
for example, PCR primer elements

promoter

region on a DNA molecule involved in RNA polymerase binding to initiate
transcription

protein_bind

non-covalent protein binding site on nucleic acid

RBS

ribosome binding site

repeat_region

region of genome containing repeating units

repeat_unit

single repeat element

rep_origin

origin of replication; starting site for duplication of nucleic acid to
give two identical copies

rRNA

mature ribosomal RNA; the RNA component of the ribonucleoprotein
particle (ribosome) which assembles amino acids into proteins

S_region

switch region of immunoglobulin heavy chains; involved in the
rearrangement of heavy chain DNA leading to the expression of a
different immunoglobulin class from the same B-cell

satellite

many tandem repeats (identical or related) of a short basic repeating
unit; many have a base composition or other property different from the
genome average that allows them to be separated from the bulk (main
band) genomic DNA

scRNA

small cytoplasmic RNA; any one of several small cytoplasmic RNA
molecules present in the cytoplasm and (sometimes) nucleus of a
eukaryote

sig_peptide

signal peptide coding sequence; coding sequence for an N-terminal domain
of a secreted protein; this domain is involved in attaching nascent
polypeptide to the membrane; leader sequence

snRNA

small nuclear RNA; any one of many small RNA species confined to the
nucleus; several of the snRNAs are involved in splicing or other RNA
processing reactions

source

identifies the biological source of the specified span of the sequence;
this key is mandatory; every entry will have, as a minimum, a single
source key spanning the entire sequence; more than one source key per
sequence is permissable

stem_loop

hairpin; a double-helical region formed by base-pairing between adjacent
(inverted) complementary sequences in a single strand of RNA or DNA

STS

Sequence Tagged Site; short, single-copy DNA sequence that characterizes
a mapping landmark on the genome and can be detected by PCR; a region of
the genome can be mapped by determining the order of a series of STSs

TATA_signal

TATA box; Goldberg-Hogness box; a conserved AT-rich septamer found about
25 bp before the start point of each eukaryotic RNA polymerase II
transcript unit which may be involved in positioning the enzyme for
correct initiation; consensus=TATA(A or T)A(A or T)

terminator

sequence of DNA located either at the end of the transcript or adjacent
to a promoter region that causes RNA polymerase to terminate
transcription; may also be site of binding of repressor protein

transit_peptide

transit peptide coding sequence; coding sequence for an N-terminal
domain of a nuclear-encoded organellar protein; this domain is involved
in post-translational import of the protein into the organelle

Key

Description

tRNA

mature transfer RNA, a small RNA molecule (75-85 bases long) that
mediates the translation of a nucleic acid sequence into an amino acid
sequence

unsure

author is unsure of exact sequence in this region

V_region

variable region of immunoglobulin light and heavy chains, and T-cell
receptor alpha, beta, and gamma chains; codes for the variable amino
terminal portion; can be made up from V_segments, D_segments, N_regions,
and J_segments

V_segment

variable segment of immunoglobulin light and heavy chains, and T-cell
receptor alpha, beta, and gamma chains; codes for most of the variable
region (V_region) and the last few amino acids of the leader peptide

variation

a related strain contains stable mutations from the same gene (for
example, RFLPs, polymorphisms, etc.) which differ from the presented
sequence at this location (and possibly others)

3 4clip

34-most region of a precursor transcript that is clipped off during
processing

34UTR

region at the 34 end of a mature transcript (following the stop codon)
that is not translated into a protein

54clip

54-most region of a precursor transcript that is clipped off during
processing

54UTR

region at the 54 end of a mature transcript (preceding the initiation
codon) that is not translated into a protein

-10_signal

pribnow box; a conserved region about 10 bp upstream of the start point
of bacterial transcription units which may be involved in binding RNA
polymerase; consensus=TAtAaT

-35_signal

a conserved hexamer about 35 bp upstream of the start point of bacterial
transcription units; consensus=TTGACa [ ] or TGTTGACA [ ]

Table 6: List of Feature Keys Related to Protein Sequences

Key

Description

CONFLICT

different papers report differing sequences

VARIANT

authors report that sequence variants exist

VARSPLIC

description of sequence variants produced by alternative splicing

MUTAGEN

site which has been experimentally altered

MOD_RES

post-translational modification of a residue

ACETYLATION

N-terminal or other

AMIDATION

generally at the C-terminal of a mature active peptide

BLOCKED

undetermined N- or C-terminal blocking group

FORMYLATION

of the N-terminal methionine

GAMMA-CARBOXYGLUTAMIC ACID HYDROXYLATION

of asparagine, aspartic acid, proline or lysine

METHYLATION

generally of lysine or arginine

PHOSPHORYLATION

of serine, threonine, tyrosine, aspartic acid or histidine

PYRROLIDONE CARBOXYLIC ACID

N-terminal glutamate which has formed an internal cyclic lactam

SULFATATION

generally of tyrosine

LIPID

covalent binding of a lipidic moiety

MYRISTATE

myristate group attached through an amide bond to the N-terminal glycine
residue of the mature form of a protein or to an internal lysine residue

PALMITATE

palmitate group attached through a thioether bond to a cysteine residue
or through an ester bond to a serine or threonine residue

FARNESYL

farnesyl group attached through a thioether bond to a cysteine residue

GERANYL-GERANYL

geranyl-geranyl group attached through a thioether bond to a cysteine
residue

GPI-ANCHOR

glycosyl-phosphatidylinositol (GPI) group linked to the alpha-carboxyl
group of the C-terminal residue of the mature form of a protein

N-ACYL DIGLYCERIDE

N-terminal cysteine of the mature form of a prokaryotic lipoprotein with
an amide-linked fatty acid and a glyceryl group to which two fatty acids
are linked by ester linkages

DISULFID

disulfide bond; the FROM and TO endpoints represent the two residues
which are linked by an intra-chain disulfide bond; if the FROM and TO
endpoints are identical, the disulfide bond is an interchain one and the
description field indicates the nature of the cross-link

THIOLEST

thiolester bond; the `FROM' and `TO' endpoints represent the two
residues which are linked by the thiolester bond

THIOETH

thioether bond; the `FROM' and `TO' endpoints represent the two residues
which are linked by the thioether bond

CARBOHYD

glycosylation site; the nature of the carbohydrate (if known) is given
in the description field

METAL

binding site for a metal ion; the description field indicates the nature
of the metal

BINDING

binding site for any chemical group (co-enzyme, prosthetic group, etc.);
the chemical nature of the group is given in the description field

SIGNAL

extent of a signal sequence (prepeptide)

TRANSIT

extent of a transit peptide (mitochondrial, chloroplastic, or for a
microbody)

PROPEP

extent of a propeptide

CHAIN

extent of a polypeptide chain in the mature protein

PEPTIDE

extent of a released active peptide

DOMAIN

extent of a domain of interest on the sequence; the nature of that
domain is given in the description field

CA_BIND

extent of a calcium-binding region

DNA_BIND

extent of a DNA-binding region

NP_BIND

extent of a nucleotide phosphate binding region; the nature of the
nucleotide phosphate is indicated in the description field

TRANSMEM

extent of a transmembrane region

ZN_FING

extent of a zinc finger region

SIMILAR

extent of a similarity with another protein sequence; precise
information, relative to that sequence is given in the description field

REPEAT

extent of an internal sequence repetition

HELIX

secondary structure: Helices, for example, Alpha-helix, 3(10) helix, or
Pi-helix

STRAND

secondary structure: Beta-strand, for example, Hydrogen bonded
beta-strand, or Residue in an isolated beta-bridge

TURN

secondary structure Turns, for example, H-bonded turn (3-turn, 4-turn or
5-turn)

ACT_SITE

amino acid(s) involved in the activity of an enzyme

SITE

any other interesting site on the sequence

INIT_MET

the sequence is known to start with an initiator methionine

NON_TER

the residue at an extremity of the sequence is not the terminal residue;
if applied to position 1, this signifies that the first position is not
the N-terminus of the complete molecule; if applied to the last
position, it signifies that this position is not the C-terminus of the
complete molecule; there is no description field for this key

NON_CONS

non consecutive residues; indicates that two residues in a sequence are
not consecutive and that there are a number of unsequenced residues
between them

UNSURE

uncertainties in the sequence; used to describe region(s) of a sequence
for which the authors are unsure about the sequence assignment

---SECTION---3 Specimen Sequence Listing

&lt;110&gt; Smith, John; Smithgene Inc.

&lt;120&gt; Example of a Sequence Listing

&lt;130&gt; 01-00001

&lt;140&gt; PCT/EP98/00001

&lt;141&gt; 1998-12-31

&lt;150&gt; US 08/999,999

&lt;151&gt; 1997-10-15

&lt;160&gt; 4

&lt;170&gt; PatentIn version 2.0

&lt;210&gt; 1

&lt;211&gt; 389

&lt;212&gt; DNA

&lt;213&gt; Paramecium sp.

&lt;220&gt;

&lt;221&gt; CDS

&lt;222&gt; (279)...(389)

&lt;300&gt;

&lt;301&gt; Doe, Richard

&lt;302&gt; Isolation and Characterization of a Gene Encoding a Protease
from Paramecium sp.

&lt;303&gt; Journal of Genes

&lt;304&gt; 1

&lt;305&gt; 4

&lt;306&gt; 1-7

&lt;307&gt; 1988-06-31

&lt;308&gt; 123456

&lt;309&gt; 1988-06-31

&lt;400&gt; 1

agctgtagtc attcctgtgt cctcttctct ctgggcttct caccctgcta atcagatctc 60

agggagagtg tcttgaccct cctctgcctt tgcagcttca caggcaggca ggcaggcagc 120

tgatgtggca attgctggca gtgccacagg cttttcagcc aggcttaggg tgggttccgc 180

cgcggcgcgg cggcccctct cgcgctcctc tcgcgcctct ctctcgctct cctctcgctc 240

ggacctgatt aggtgagcag gaggaggggg cagttagc at gt tc at tt ag 29

g t a g c c 6 Me Va Se Me Ph Se t l r t e r 1 5

tt tc tt aa tg cc gg tt tg tt tt gt tg tt tt ca 34

g t c a g t a t t g t t t g c a 4 Le Se Ph Ly Tr Pr Gl Ph Cy Le Ph Va Cy
Le Ph Gl u r e s p o y e s u e l s u e n 10 30 20

tg cc aa gt ct cc tg ca tc tc ct ca cc aa ct 38

t c a c c c t c a a g g g t t 9 Cy Pr Ly Va Le Pr Cy Hi Se Se Le Gl Pr
As Le s o s l u o s s r r u n o n u 25 30 35

&lt;210&gt; 2

&lt;211&gt; 37

&lt;212&gt; PRT

&lt;213&gt; Paramecium sp.

&lt;400&gt; 2

Met Val Ser Met Phe Ser Leu Ser Phe Lys Trp Pro Gly Phe Cys Leu

1 5 10 15

Phe Val Cys Leu Phe Gln Cys Pro Lys Val Leu Pro Cys His Ser Ser

20 25 30

Leu Gln Pro Asn Leu

35

&lt;210&gt; 3

&lt;211&gt; 11

&lt;212&gt; PRT

&lt;213&gt; Artificial Sequence

&lt;220&gt;

&lt;223&gt; Designed peptide based on size and polarity to act as a
linker between the alpha and beta chains of Protein XYZ.

&lt;400&gt; 3

Met Val Asn Leu Glu Pro Met His Thr Glu Ile

1 5 10

&lt;210&gt; 4

&lt;400&gt; 4

000

D

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