# cumulative hits at level: 3 from root 
# for molecular.clean
chlorophyll binding	44
transferase activity, transferring acyl groups	215
polyamine-transporting ATPase activity	1
histone binding	19
chaperone binding	7
xenobiotic-transporting ATPase activity	1
oxidoreductase activity, acting on NADH or NADPH	126
kinase inhibitor activity	17
immunoglobulin binding	24
porin activity	114
deacetylase activity	8
RNA binding	688
oxidoreductase activity, acting on CH2 groups	7
epidermal growth factor receptor binding	14
coenzyme binding	108
protein domain specific binding	73
dynein binding	3
calmodulin binding	67
specific transcriptional repressor activity	3
insulin-like growth factor receptor binding	16
benzodiazepine receptor binding	2
transcription factor binding	99
guanylate cyclase activity	25
guanylate cyclase activator activity	3
translation repressor activity, nucleic acid binding	5
RAN protein binding	28
protease inhibitor activity	69
transferase activity, transferring one-carbon groups	153
racemase and epimerase activity	55
pre-mRNA splicing factor activity	5
androgen binding	14
GTPase activator activity	30
multidrug transporter activity	3
transferase activity, transferring sulfur-containing groups	11
thiol peroxidase activity	7
anion transporter activity	47
minus-end-directed microtubule motor activity	3
cyclosporin A binding	35
general transcriptional repressor activity	1
metal ion transporter activity	84
protein self binding	76
small GTPase regulatory/interacting protein activity	46
catalase activity	85
protein carrier activity	16
RNA polymerase II transcription factor activity, enhancer binding	2
FMN binding	26
growth factor activity	22
ferrochelatase activity	5
glutathione peroxidase activity	13
oxidoreductase activity, acting on the aldehyde or oxo group of donors	174
antibiotic transporter activity	42
amino acid transporter activity	58
heat shock protein binding	64
oxidoreductase activity, oxidizing metal ions	11
receptor regulator activity	2
oxidoreductase activity, acting on superoxide radicals as acceptor	19
ubiquitin-like activating enzyme activity	10
translation initiation factor activity	120
cytidine deaminase activity	3
ligase activity, forming phosphoric ester bonds	53
alpha-amylase inhibitor activity	4
protein kinase regulator activity	61
monooxygenase activity	293
acyl carrier activity	13
penicillin binding	2
electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	10
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity	4
amino acid binding	51
translation activator activity	3
biotin binding	5
arsenate reductase activity	7
organic acid:sodium symporter activity	26
transcription corepressor activity	51
cytochrome-c peroxidase activity	32
type I protein secretor activity	4
electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	10
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond	133
macrolide binding	36
GPI-anchor transamidase activity	1
ubiquitin conjugating enzyme activity	74
1-aminocyclopropane-1-carboxylate deaminase activity	1
GTPase inhibitor activity	15
ligase activity, forming carbon-oxygen bonds	51
hydrolase activity, acting on ether bonds	15
oxidoreductase activity, acting on the CH-NH group of donors	31
folic acid transporter activity	2
phospholipid binding	32
taurine transporter activity	1
polyol transporter activity	12
protein C-terminus binding	4
[methionine synthase] reductase activity	3
nucleocytoplasmic transporter activity	2
retinoid binding	14
primary active transporter activity	165
ATPase activity, coupled to transmembrane movement of ions	92
carbon-oxygen lyase activity	197
oxidoreductase activity, acting on the CH-NH2 group of donors	35
allene-oxide cyclase activity	5
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	89
fatty acid binding	9
transferase activity, transferring aldehyde or ketonic groups	28
DNA gyrase inhibitor activity	30
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	200
alpha-type channel activity	113
isoamylase activity	2
cis-trans isomerase activity	54
alpha-ketoacid dehydrogenase activity	5
drug:hydrogen antiporter activity	42
amino acid-transporting ATPase activity	1
dCMP deaminase activity	3
protein dimerization activity	154
cation binding	1473
sterol transporter activity	1
TATA-binding protein binding	4
nuclear hormone receptor binding	9
oxidoreductase activity, acting on diphenols and related substances as donors	29
ligase activity, forming carbon-carbon bonds	4
photoreceptor activity	49
specific RNA polymerase II transcription factor activity	6
protein binding, bridging	5
polysaccharide binding	43
GTP-dependent protein binding	7
ubiquitin binding	24
electron donor activity	10
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	1
cytoskeletal protein binding	150
phosphoprotein binding	32
neurexin binding	1
cyclic nucleotide binding	7
adenylate cyclase activity	15
sugar binding	204
oxidoreductase activity, acting on hydrogen as donor	8
oxidoreductase activity, acting on iron-sulfur proteins as donors	27
beta-catenin binding	16
phosphopantetheine binding	12
protein phosphatase regulator activity	13
pyridoxal phosphate binding	22
dihydrolipoyl dehydrogenase activity	6
ribosome binding	10
hydrolase activity, acting on glycosyl bonds	301
fatty acid transporter activity	2
sugar transporter activity	74
lamin binding	1
phospholipase activator activity	1
carbon-carbon lyase activity	457
ferredoxin reductase activity	25
receptor signaling protein serine/threonine kinase signaling protein activity	2
trypanothione-disulfide reductase activity	2
carbon-nitrogen lyase activity	19
DNA binding	1765
siderophore-iron transporter activity	1
plus-end-directed microtubule motor activity	4
receptor signaling protein serine/threonine kinase activity	141
protein translocase activity	6
heme binding	83
ubiquitin-like conjugating enzyme activity	24
hydrolase activity, acting on acid halide bonds	5
unfolded protein binding	290
ligand-dependent nuclear receptor activity	1
channel regulator activity	14
guanine deaminase activity	3
nucleotide-sugar transporter activity	2
cytochrome-b5 reductase activity	12
squalene-hopene cyclase activity	2
signal sequence binding	15
phorbol ester receptor activity	4
phosphorus-oxygen lyase activity	30
aldo-keto reductase activity	12
negative transcription elongation factor activity	1
peptidase activity	672
DNA helicase activity	16
hydrolase activity, acting on acid carbon-carbon bonds	6
transferase activity, transferring glycosyl groups	280
ligase activity, forming carbon-nitrogen bonds	360
NADPH-hemoprotein reductase activity	9
transferase activity, transferring phosphorus-containing groups	1180
heme-copper terminal oxidase activity	14
receptor signaling protein tyrosine kinase activity	2
chaperone activity	34
hydrolase activity, acting on ester bonds	618
electrochemical potential-driven transporter activity	198
ice binding	1
receptor signaling complex scaffold activity	3
death receptor binding	1
ATPase stimulator activity	12
oxidoreductase activity, acting on heme group of donors	14
ubiquitin activating enzyme activity	7
sterol carrier activity	2
ATP-dependent helicase activity	137
adenosine deaminase activity	2
oxidoreductase activity, acting on the CH-CH group of donors	107
enzyme binding	48
NADPH dehydrogenase activity	10
cobalamin transporter activity	1
4-alpha-glucanotransferase activity	1
signal recognition particle binding	5
geranylgeranyl reductase activity	5
disulfide oxidoreductase activity	122
nucleotide transporter activity	9
DNA helicase IV activity	1
phospholipase inhibitor activity	1
DNA topoisomerase activity	5
intramolecular transferase activity	42
transferase activity, transferring alkyl or aryl (other than methyl) groups	121
purine nucleotide binding	1823
intramolecular oxidoreductase activity	151
ligase activity, forming nitrogen-metal bonds	2
MHC protein binding	11
snoRNP binding	2
bile acid-exporting ATPase activity	1
diacylglycerol binding	23
rubredoxin reductase activity	7
transmembrane receptor activity	144
translation termination factor activity	6
translation elongation factor activity	99
kinase activator activity	20
sigma factor activity	1
SNAP receptor activity	3
oxidoreductase activity, acting on phosphorus or arsenic in donors	7
positive transcription elongation factor activity	5
cytosine deaminase activity	3
heme transporter activity	2
diaminohydroxyphosphoribosylaminopyrimidine deaminase activity	1
nucleobase transporter activity	9
transmembrane receptor protein tyrosine kinase signaling protein activity	9
polyamine transporter activity	46
carboxylic acid transporter activity	87
sulfite reductase (NADPH) activity	6
oxidoreductase activity, acting on CH-OH group of donors	314
metal ion binding	1835
oligopeptide transporter activity	28
sphingosine hydroxylase activity	2
phosphatase inhibitor activity	5
ATP-dependent protein binding	4
protein N-terminus binding	2
carbon-sulfur lyase activity	63
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	254
electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity	9
cyclin binding	3
oxidoreductase activity, acting on other nitrogenous compounds as donors	20
transcription coactivator activity	43
cytokine activity	39
oxysterol binding	1
NADH dehydrogenase activity	45
intramolecular lyase activity	1
retinal binding	14
dioxygenase activity	227
phospholipid-hydroperoxide glutathione peroxidase activity	7
phospholipid transporter activity	1
oxidoreductase activity, acting on peroxide as acceptor	234
hydrolase activity, acting on acid anhydrides	688
SNARE binding	10
cation transporter activity	304
hormone activity	5
nucleoside transporter activity	1
transferase activity, transferring nitrogenous groups	81
L-ascorbate peroxidase activity	36
electron carrier activity	20
RNA helicase activity	28
oxidoreductase activity, acting on sulfur group of donors	62
ligase activity, forming carbon-sulfur bonds	25
thioredoxin peroxidase activity	7
general RNA polymerase II transcription factor activity	6
clathrin binding	7
# cumulative hits at level: 3 from root 
# for molecular.clean
transferase activity, transferring acyl groups	274
chlorophyll binding	24
histone binding	33
chaperone binding	7
xenobiotic-transporting ATPase activity	3
oxidoreductase activity, acting on NADH or NADPH	176
immunoglobulin binding	37
kinase inhibitor activity	30
porin activity	182
deacetylase activity	8
RNA binding	865
oxidoreductase activity, acting on CH2 groups	3
epidermal growth factor receptor binding	22
coenzyme binding	134
protein domain specific binding	109
dynein binding	5
calmodulin binding	67
insulin-like growth factor receptor binding	23
benzodiazepine receptor binding	3
transcription factor binding	136
guanylate cyclase activity	39
guanylate cyclase activator activity	2
translation repressor activity, nucleic acid binding	11
sirohydrochlorin cobaltochelatase activity	2
RAN protein binding	46
protease inhibitor activity	102
transferase activity, transferring one-carbon groups	183
racemase and epimerase activity	73
growth factor binding	4
pre-mRNA splicing factor activity	7
androgen binding	12
GTPase activator activity	38
transferase activity, transferring sulfur-containing groups	22
multidrug transporter activity	8
anion transporter activity	57
thiol peroxidase activity	6
minus-end-directed microtubule motor activity	1
cyclosporin A binding	51
general transcriptional repressor activity	2
metal ion transporter activity	110
protein self binding	100
catalase activity	99
small GTPase regulatory/interacting protein activity	60
protein carrier activity	18
RNA polymerase II transcription factor activity, enhancer binding	1
FMN binding	48
growth factor activity	20
ferrochelatase activity	6
glutathione peroxidase activity	15
oxidoreductase activity, acting on the aldehyde or oxo group of donors	244
antibiotic transporter activity	114
heat shock protein binding	79
amino acid transporter activity	60
oxidoreductase activity, oxidizing metal ions	19
receptor regulator activity	3
oxidoreductase activity, acting on superoxide radicals as acceptor	35
ubiquitin-like activating enzyme activity	8
translation initiation factor activity	153
cytidine deaminase activity	3
ligase activity, forming phosphoric ester bonds	67
alpha-amylase inhibitor activity	8
monooxygenase activity	307
protein kinase regulator activity	86
acyl carrier activity	22
penicillin binding	11
electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity	8
electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity	3
translation activator activity	5
amino acid binding	58
biotin binding	2
organic acid:sodium symporter activity	29
arsenate reductase activity	7
transcription corepressor activity	78
cytochrome-c peroxidase activity	54
type I protein secretor activity	5
electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	6
oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond	122
macrolide binding	50
GPI-anchor transamidase activity	1
ubiquitin conjugating enzyme activity	85
1-aminocyclopropane-1-carboxylate deaminase activity	2
integrin binding	1
GTPase inhibitor activity	24
ligase activity, forming carbon-oxygen bonds	66
oxidoreductase activity, acting on the CH-NH group of donors	36
hydrolase activity, acting on ether bonds	15
folic acid transporter activity	2
phospholipid binding	28
carnitine transporter activity	1
polyol transporter activity	10
[methionine synthase] reductase activity	1
protein C-terminus binding	8
nucleocytoplasmic transporter activity	3
retinoid binding	12
primary active transporter activity	247
ATPase activity, coupled to transmembrane movement of ions	149
carbon-oxygen lyase activity	249
oxidoreductase activity, acting on the CH-NH2 group of donors	23
folic acid binding	1
Pol II transcription elongation factor activity	1
coenzyme transporter activity	3
allene-oxide cyclase activity	11
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	107
fatty acid binding	12
transferase activity, transferring aldehyde or ketonic groups	47
DNA gyrase inhibitor activity	95
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	245
alpha-type channel activity	189
glutathione S-conjugate-exporting ATPase activity	2
isoamylase activity	2
cis-trans isomerase activity	76
alpha-ketoacid dehydrogenase activity	1
drug:hydrogen antiporter activity	114
dCMP deaminase activity	3
protein dimerization activity	186
cation binding	1734
sterol transporter activity	2
TATA-binding protein binding	9
nuclear hormone receptor binding	7
oxidoreductase activity, acting on diphenols and related substances as donors	38
ligase activity, forming carbon-carbon bonds	1
photoreceptor activity	42
specific RNA polymerase II transcription factor activity	4
protein binding, bridging	7
polysaccharide binding	52
GTP-dependent protein binding	15
ubiquitin binding	35
electron donor activity	7
cytoskeletal protein binding	203
phosphoprotein binding	42
neurexin binding	4
cyclic nucleotide binding	8
adenylate cyclase activity	25
sugar binding	218
oxidoreductase activity, acting on hydrogen as donor	6
oxidoreductase activity, acting on iron-sulfur proteins as donors	22
beta-catenin binding	14
phosphopantetheine binding	26
protein phosphatase regulator activity	22
pyridoxal phosphate binding	34
dihydrolipoyl dehydrogenase activity	8
ribosome binding	14
hydrolase activity, acting on glycosyl bonds	442
fatty acid transporter activity	2
sugar transporter activity	72
lamin binding	1
phospholipase activator activity	1
carbon-carbon lyase activity	406
receptor signaling protein serine/threonine kinase signaling protein activity	1
ferredoxin reductase activity	17
trypanothione-disulfide reductase activity	5
carbon-nitrogen lyase activity	37
DNA binding	2085
plus-end-directed microtubule motor activity	2
cholesterol binding	2
receptor signaling protein serine/threonine kinase activity	134
carbon-halide lyase activity	1
protein translocase activity	15
heme binding	92
ubiquitin-like conjugating enzyme activity	26
hydrolase activity, acting on acid halide bonds	10
unfolded protein binding	360
ligand-dependent nuclear receptor activity	2
channel regulator activity	12
guanine deaminase activity	4
nucleotide-sugar transporter activity	2
cytochrome-b5 reductase activity	15
squalene-hopene cyclase activity	1
signal sequence binding	10
phorbol ester receptor activity	3
phosphorus-oxygen lyase activity	47
aldo-keto reductase activity	21
negative transcription elongation factor activity	1
peptidase activity	849
DNA helicase activity	21
hydrolase activity, acting on acid carbon-carbon bonds	2
transferase activity, transferring glycosyl groups	337
ligase activity, forming carbon-nitrogen bonds	484
NADPH-hemoprotein reductase activity	14
heme-copper terminal oxidase activity	15
transferase activity, transferring phosphorus-containing groups	1246
receptor signaling protein tyrosine kinase activity	4
receptor signaling protein tyrosine phosphatase activity	2
chaperone activity	48
hydrolase activity, acting on ester bonds	761
heat shock protein activity	3
electrochemical potential-driven transporter activity	293
ice binding	1
receptor signaling complex scaffold activity	2
death receptor binding	1
ATPase stimulator activity	19
oxidoreductase activity, acting on heme group of donors	15
ubiquitin activating enzyme activity	7
sterol carrier activity	1
ATP-dependent helicase activity	196
choline transporter activity	2
adenosine deaminase activity	3
oxidoreductase activity, acting on the CH-CH group of donors	129
enzyme binding	78
NADPH dehydrogenase activity	25
cobalamin-transporting ATPase activity	2
cobalamin transporter activity	3
signal recognition particle binding	11
geranylgeranyl reductase activity	4
disulfide oxidoreductase activity	149
nucleotide transporter activity	27
phospholipase inhibitor activity	2
DNA helicase IV activity	2
DNA topoisomerase activity	7
intramolecular transferase activity	53
transferase activity, transferring alkyl or aryl (other than methyl) groups	247
purine nucleotide binding	2065
ligase activity, forming nitrogen-metal bonds	2
intramolecular oxidoreductase activity	251
MHC protein binding	10
bile acid-exporting ATPase activity	5
snoRNP binding	1
diacylglycerol binding	21
rubredoxin reductase activity	11
transmembrane receptor activity	167
translation termination factor activity	5
translation elongation factor activity	143
kinase activator activity	28
SNAP receptor activity	5
oxidoreductase activity, acting on phosphorus or arsenic in donors	7
positive transcription elongation factor activity	6
cytosine deaminase activity	3
heme transporter activity	2
diaminohydroxyphosphoribosylaminopyrimidine deaminase activity	1
nucleobase transporter activity	25
transmembrane receptor protein tyrosine kinase signaling protein activity	10
polyamine transporter activity	43
carboxylic acid transporter activity	103
sulfite reductase (NADPH) activity	6
oxidoreductase activity, acting on CH-OH group of donors	396
metal ion binding	2261
oligopeptide transporter activity	25
sphingosine hydroxylase activity	1
phosphatase inhibitor activity	6
ATP-dependent protein binding	3
carbon-sulfur lyase activity	109
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	218
electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity	3
cyclin binding	6
oxidoreductase activity, acting on other nitrogenous compounds as donors	25
soluble NSF attachment protein activity	3
transcription coactivator activity	59
cytokine activity	40
oxysterol binding	2
NADH dehydrogenase activity	57
intramolecular lyase activity	4
retinal binding	12
dioxygenase activity	197
phospholipid-hydroperoxide glutathione peroxidase activity	7
phospholipid transporter activity	3
oxidoreductase activity, acting on peroxide as acceptor	399
hydrolase activity, acting on acid anhydrides	947
SNARE binding	15
cation transporter activity	482
hormone activity	7
nucleoside transporter activity	1
transferase activity, transferring nitrogenous groups	99
L-ascorbate peroxidase activity	61
electron carrier activity	18
RNA helicase activity	33
oxidoreductase activity, acting on sulfur group of donors	73
ligase activity, forming carbon-sulfur bonds	32
thioredoxin peroxidase activity	9
general RNA polymerase II transcription factor activity	12
clathrin binding	8
ornithine decarboxylase inhibitor activity	1