TOXICOLOGY DATA MANAGEMENT SYSTEM
                 HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY
===========================================================================

ALL ORGANS                                                      B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Benign Tumors            Total    197/299(65.9%)         207/302(68.5%)
                         Mean(sd) 65.9%(13.7)            68.6%(10.8)
                         Range    26/50 - 43/50          28/52 - 40/50
   Males
   35/50 38/50 43/50 26/50 27/50 28/49
   Females
   28/52 40/50 29/50 39/50 34/50 37/50
---------------------------------------------------------------------------
Malignant Tumors         Total    151/299(50.5%)         149/302(49.3%)
                         Mean(sd) 50.5%(15.9)            49.3%(6.1)
                         Range    16/50 - 39/50          22/50 - 30/50
   Males
   16/50 21/50 39/50 22/50 29/50 24/49
   Females
   27/52 22/50 25/50 23/50 30/50 22/50
---------------------------------------------------------------------------
Malignant and Benign     Total    260/299(87%)           270/302(89.4%)
Tumors                   Mean(sd) 87.0%(9.5)             89.5%(5.7)
                         Range    35/50 - 49/50          41/52 - 47/50
   Males
   43/50 46/50 49/50 35/50 45/50 42/49
   Females
   41/52 47/50 45/50 47/50 44/50 46/50
---------------------------------------------------------------------------
Hemangioma               Total    6/299(2%)              11/302(3.6%)
                         Mean(sd) 2.0%(2.5)              3.6%(2.3)
                         Range    0/50 - 3/50            0/50 - 3/50
   Males
   2/50  0/50  3/50  0/50  1/50  0/49
   Females
   3/52  3/50  2/50  2/50  0/50  1/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    30/299(10%)            10/302(3.3%)
                         Mean(sd) 10.0%(4.2)             3.3%(2.4)
                         Range    2/50 - 8/50            0/50 - 3/50
   Males
   4/50  2/50  6/50  6/50  8/50  4/49
   Females
   3/52  2/50  0/50  1/50  3/50  1/50
---------------------------------------------------------------------------
Hemangiosarcoma or       Total    36/299(12%)            21/302(7%)
Hemangioma               Mean(sd) 12.0%(5.5)             6.9%(3.1)
                         Range    2/50 - 9/50            2/50 - 6/52
   Males
   6/50  2/50  9/50  6/50  9/50  4/49
   Females
   6/52  5/50  2/50  3/50  3/50  2/50
---------------------------------------------------------------------------
Histiocytic Sarcoma      Total    1/299(0.3%)            11/302(3.6%)
                         Mean(sd) 0.3%(0.8)              3.6%(2.6)
                         Range    0/50 - 1/50            0/50 - 3/50
   Males
   0/50  0/50  0/50  1/50  0/50  0/49
   Females
   3/52  1/50  3/50  1/50  0/50  3/50
---------------------------------------------------------------------------
Leukemia: Erythrocytic   Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leukemia: Granulocytic   Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
Leukemia: Lymphocytic,   Total    0/299(0%)              0/302(0%)
Monocytic, Mononuclear,  Mean(sd) 0.0%(0.0)              0.0%(0.0)
or Undifferentiated      Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Malignant Lymphoma:      Total    15/299(5%)             52/302(17.2%)
Histiocytic,             Mean(sd) 5.0%(3.7)              17.3%(7.3)
Lymphocytic, Mixed, NOS, Range    0/50 - 5/50            3/50 - 13/50
or Undifferentiated Cell
Type
   Males
   3/50  0/50  5/50  2/50  4/50  1/49
   Females
   7/52  12/50 8/50  13/50 9/50  3/50
---------------------------------------------------------------------------
Osteoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma             Total    0/299(0%)              2/302(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.0)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  1/50  0/50  0/50  1/50
---------------------------------------------------------------------------
Osteosarcoma or Osteoma  Total    0/299(0%)              2/302(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.0)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  1/50  0/50  0/50  1/50
---------------------------------------------------------------------------
===========================================================================

ADRENAL CORTEX                                                  B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    9/299(3%)              3/302(1%)
                         Mean(sd) 3.0%(4.0)              1.0%(1.1)
                         Range    0/50 - 5/50            0/52 - 1/50
   Males
   0/50  5/50  0/50  0/50  2/50  2/49
   Females
   0/52  0/50  1/50  1/50  1/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL                      B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/300(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/50  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ADRENAL MEDULLA                                                 B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Pheochromocytoma Benign  Total    1/298(0.3%)            7/301(2.3%)
                         Mean(sd) 0.3%(0.8)              2.3%(2.0)
                         Range    0/49 - 1/50            0/51 - 2/50
   Males
   1/50  0/49  0/50  0/50  0/50  0/49
   Females
   0/51  2/50  0/50  2/50  1/50  2/50
---------------------------------------------------------------------------
Pheochromocytoma Complex Total    0/298(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/51 - 0/51
   Males
   0/50  0/49  0/50  0/50  0/50  0/49
   Females
   0/51  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Pheochromocytoma         Total    0/298(0%)              0/301(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/51 - 0/51
   Males
   0/50  0/49  0/50  0/50  0/50  0/49
   Females
   0/51  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Pheochromocytoma:        Total    1/298(0.3%)            7/301(2.3%)
Benign, Complex,         Mean(sd) 0.3%(0.8)              2.3%(2.0)
Malignant, NOS           Range    0/49 - 1/50            0/51 - 2/50
   Males
   1/50  0/49  0/50  0/50  0/50  0/49
   Females
   0/51  2/50  0/50  2/50  1/50  2/50
---------------------------------------------------------------------------
===========================================================================

BONE MARROW                                                     B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    2/299(0.7%)            3/302(1%)
                         Mean(sd) 0.7%(1.0)              1.0%(1.1)
                         Range    0/50 - 1/50            0/52 - 1/50
   Males
   0/50  1/50  0/50  0/50  1/50  0/49
   Females
   0/52  1/50  0/50  0/50  1/50  1/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor NOS      Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

BONE                                                            B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrosarcoma             Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Osteoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma             Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  1/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma or Osteoma  Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  1/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

BRAIN                                                           B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Astrocytoma Benign       Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Meningioma Malignant     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Meningioma: Benign,      Total    0/299(0%)              0/302(0%)
Malignant, NOS           Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Oligodendroglioma Benign Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Oligodendroglioma        Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Oligodendroglioma,       Total    0/299(0%)              0/302(0%)
Glioma, or Astrocytoma   Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

CLITORAL/PREPUTIAL GLAND                                        B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

EAR                                                             B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Basosquamous Tumor       Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibroma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    1/299(0.3%)            0/302(0%)
                         Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   1/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

EPIDIDYMIS                                                      B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/299(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Leiomyoma                Total    1/299(0.3%)
                         Mean(sd) 0.3%(0.8)
                         Range    0/50 - 1/50
   Males
   0/50  1/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
===========================================================================

ESOPHAGUS                                                       B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

EYE                                                             B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Sarcoma                  Total    1/299(0.3%)            0/302(0%)
                         Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  1/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

GALLBLADDER                                                     B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/283(0%)              0/292(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/52 - 0/52
   Males
   0/49  0/45  0/49  0/48  0/47  0/45
   Females
   0/52  0/49  0/49  0/49  0/47  0/46
---------------------------------------------------------------------------
===========================================================================

HARDERIAN GLAND                                                 B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    8/299(2.7%)            10/302(3.3%)
                         Mean(sd) 2.7%(1.6)              3.3%(2.4)
                         Range    0/50 - 2/49            0/50 - 3/50
   Males
   2/50  0/50  1/50  2/50  1/50  2/49
   Females
   2/52  1/50  3/50  0/50  1/50  3/50
---------------------------------------------------------------------------
Carcinoma                Total    1/299(0.3%)            5/302(1.7%)
                         Mean(sd) 0.3%(0.8)              1.6%(1.4)
                         Range    0/50 - 1/50            0/50 - 2/52
   Males
   1/50  0/50  0/50  0/50  0/50  0/49
   Females
   2/52  0/50  1/50  1/50  1/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    9/299(3%)              15/302(5%)
                         Mean(sd) 3.0%(2.1)              5.0%(2.7)
                         Range    0/50 - 3/50            1/50 - 4/50
   Males
   3/50  0/50  1/50  2/50  1/50  2/49
   Females
   4/52  1/50  4/50  1/50  2/50  3/50
---------------------------------------------------------------------------
===========================================================================

HEART                                                           B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE LARGE: CECUM                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE LARGE: COLON/RECTUM                                   B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE SMALL: DUODENUM                                       B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Polyp Adenomatous        Total    1/299(0.3%)            1/302(0.3%)
                         Mean(sd) 0.3%(0.8)              0.3%(0.8)
                         Range    0/50 - 1/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  1/50  0/49
   Females
   0/52  0/50  0/50  0/50  1/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE SMALL: ILEUM                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE SMALL: JEJUNUM                                        B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    2/299(0.7%)            1/302(0.3%)
                         Mean(sd) 0.7%(1.7)              0.3%(0.8)
                         Range    0/50 - 2/49            0/50 - 1/52
   Males
   0/50  0/50  0/50  0/50  0/50  2/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/50 - 1/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Polyp Adenomatous        Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE SMALL: SITE UNSPECIFIED                               B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    2/299(0.7%)            1/302(0.3%)
                         Mean(sd) 0.7%(1.7)              0.3%(0.8)
                         Range    0/50 - 2/49            0/50 - 1/52
   Males
   0/50  0/50  0/50  0/50  0/50  2/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    2/299(0.7%)            1/302(0.3%)
                         Mean(sd) 0.7%(1.7)              0.3%(0.8)
                         Range    0/50 - 2/49            0/50 - 1/52
   Males
   0/50  0/50  0/50  0/50  0/50  2/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/50 - 1/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Polyp Adenomatous        Total    1/299(0.3%)            1/302(0.3%)
                         Mean(sd) 0.3%(0.8)              0.3%(0.8)
                         Range    0/50 - 1/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  1/50  0/49
   Females
   0/52  0/50  0/50  0/50  1/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ISLETS, PANCREATIC                                              B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    3/298(1%)              3/301(1%)
                         Mean(sd) 1.0%(1.7)              1.0%(1.1)
                         Range    0/50 - 2/49            0/52 - 1/50
   Males
   2/49  0/50  0/50  1/50  0/50  0/49
   Females
   0/52  0/50  1/50  0/50  1/50  1/49
---------------------------------------------------------------------------
Carcinoma                Total    2/298(0.7%)            1/301(0.3%)
                         Mean(sd) 0.7%(1.0)              0.3%(0.8)
                         Range    0/49 - 1/50            0/52 - 1/50
   Males
   0/49  1/50  0/50  0/50  1/50  0/49
   Females
   0/52  0/50  1/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    5/298(1.7%)            4/301(1.3%)
                         Mean(sd) 1.7%(1.5)              1.3%(1.6)
                         Range    0/50 - 2/49            0/52 - 2/50
   Males
   2/49  1/50  0/50  1/50  1/50  0/49
   Females
   0/52  0/50  2/50  0/50  1/50  1/49
---------------------------------------------------------------------------
===========================================================================

KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM                      B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

KIDNEY: RENAL TUBULE                                            B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    2/299(0.7%)            0/302(0%)
                         Mean(sd) 0.7%(1.0)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   0/50  1/50  0/50  1/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    2/299(0.7%)            0/302(0%)
                         Mean(sd) 0.7%(1.6)              0.0%(0.0)
                         Range    0/50 - 2/50            0/52 - 0/52
   Males
   0/50  2/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    4/299(1.3%)            0/302(0%)
                         Mean(sd) 1.3%(2.4)              0.0%(0.0)
                         Range    0/50 - 3/50            0/52 - 0/52
   Males
   0/50  3/50  0/50  1/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    1/299(0.3%)            0/302(0%)
                         Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   0/50  1/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LIVER                                                           B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Cholangiocarcinoma       Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Cholangioma              Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    1/299(0.3%)            0/302(0%)
                         Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/49            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  1/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    2/299(0.7%)            3/302(1%)
                         Mean(sd) 0.7%(1.6)              1.0%(1.7)
                         Range    0/50 - 2/50            0/52 - 2/50
   Males
   0/50  0/50  2/50  0/50  0/50  0/49
   Females
   0/52  1/50  2/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    18/299(6%)             4/302(1.3%)
                         Mean(sd) 6.0%(5.2)              1.3%(1.6)
                         Range    0/50 - 7/50            0/50 - 2/50
   Males
   3/50  0/50  5/50  2/50  7/50  1/49
   Females
   1/52  0/50  0/50  1/50  2/50  0/50
---------------------------------------------------------------------------
Hepatoblastoma           Total    1/299(0.3%)            1/302(0.3%)
                         Mean(sd) 0.3%(0.8)              0.3%(0.8)
                         Range    0/50 - 1/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  1/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
Hepatocellular Adenoma   Total    155/299(51.8%)         151/302(50%)
                         Mean(sd) 51.8%(13.5)            50.1%(12.2)
                         Range    19/50 - 37/50          18/50 - 32/50
   Males
   24/50 31/50 37/50 22/50 19/50 22/49
   Females
   20/52 32/50 18/50 32/50 23/50 26/50
---------------------------------------------------------------------------
Hepatocellular Carcinoma Total    89/299(29.8%)          45/302(14.9%)
                         Mean(sd) 29.7%(19.9)            14.9%(7.0)
                         Range    9/49 - 35/50           3/50 - 12/52
   Males
   10/50 12/50 35/50 12/50 11/50 9/49
   Females
   12/52 5/50  10/50 3/50  10/50 5/50
---------------------------------------------------------------------------
Hepatocellular           Total    90/299(30.1%)          46/302(15.2%)
Carcinoma or             Mean(sd) 30.1%(19.8)            15.2%(6.8)
Hepatoblastoma           Range    9/49 - 35/50           3/50 - 12/52
   Males
   10/50 12/50 35/50 13/50 11/50 9/49
   Females
   12/52 5/50  10/50 3/50  10/50 6/50
---------------------------------------------------------------------------
Hepatocellular           Total    199/299(66.6%)         176/302(58.3%)
Carcinoma or             Mean(sd) 66.5%(15.0)            58.3%(6.1)
Hepatocellular Adenoma   Range    28/50 - 46/50          27/52 - 33/50
   Males
   29/50 39/50 46/50 28/50 28/50 29/49
   Females
   27/52 33/50 27/50 33/50 28/50 28/50
---------------------------------------------------------------------------
Hepatocellular           Total    200/299(66.9%)         176/302(58.3%)
Carcinoma,               Mean(sd) 66.9%(14.8)            58.3%(6.1)
Hepatocellular Adenoma,  Range    28/50 - 46/50          27/52 - 33/50
or Hepatoblastoma
   Males
   29/50 39/50 46/50 29/50 28/50 29/49
   Females
   27/52 33/50 27/50 33/50 28/50 28/50
---------------------------------------------------------------------------
Hepatocholangiocarcinoma Total    1/299(0.3%)            1/302(0.3%)
                         Mean(sd) 0.3%(0.8)              0.3%(0.8)
                         Range    0/50 - 1/50            0/52 - 1/50
   Males
   0/50  0/50  1/50  0/50  0/50  0/49
   Females
   0/52  0/50  1/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Ito Cell Tumor Benign    Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Ito Cell Tumor Malignant Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Ito Cell Tumor NOS       Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LUNG                                                            B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    1/299(0.3%)            0/302(0%)
                         Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  1/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Alveolar/Bronchiolar     Total    61/299(20.4%)          13/302(4.3%)
Adenoma                  Mean(sd) 20.4%(5.9)             4.3%(3.0)
                         Range    6/50 - 13/50           1/52 - 4/50
   Males
   13/50 11/50 13/50 11/50 6/50  7/49
   Females
   1/52  4/50  4/50  2/50  1/50  1/50
---------------------------------------------------------------------------
Alveolar/Bronchiolar     Total    27/299(9%)             15/302(5%)
Carcinoma                Mean(sd) 9.1%(5.5)              5.0%(4.9)
                         Range    1/50 - 8/50            0/50 - 7/50
   Males
   1/50  5/50  2/50  4/50  8/50  7/49
   Females
   1/52  2/50  2/50  0/50  7/50  3/50
---------------------------------------------------------------------------
Alveolar/Bronchiolar     Total    85/299(28.4%)          27/302(8.9%)
Carcinoma or             Mean(sd) 28.4%(2.2)             9.0%(4.7)
Alveolar/Bronchiolar     Range    12/49 - 15/50          2/52 - 8/50
Adenoma
   Males
   14/50 15/50 15/50 15/50 14/50 12/49
   Females
   2/52  6/50  5/50  2/50  8/50  4/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LYMPH NODE, MANDIBULAR                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              2/302(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.0)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   1/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
===========================================================================

LYMPH NODE, MESENTERIC                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  1/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    1/299(0.3%)            0/302(0%)
                         Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   0/50  0/50  1/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    1/299(0.3%)            0/302(0%)
                         Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  1/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    1/299(0.3%)            0/302(0%)
Malignant                Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   0/50  1/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LYMPH NODE                                                      B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  1/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Liposarcoma              Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    1/299(0.3%)            0/302(0%)
Malignant                Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   0/50  1/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  1/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LYMPH NODE: MESENTERIC                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

MAMMARY GLAND                                                   B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)              3/302(1%)
                         Mean(sd) 0.0%(0.0)              1.0%(1.1)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  1/50  0/50  1/50  1/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/299(0%)              3/302(1%)
                         Mean(sd) 0.0%(0.0)              1.0%(1.1)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  1/50  0/50  1/50  1/50  0/50
---------------------------------------------------------------------------
Fibroma, Fibroadenoma    Total    0/299(0%)              0/302(0%)
or Adenoma               Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibroma, Fibroadenoma,   Total    0/299(0%)              3/302(1%)
Carcinoma, or Adenoma    Mean(sd) 0.0%(0.0)              1.0%(1.1)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  1/50  0/50  1/50  1/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Myoepithelioma           Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

MESENTERY                                                       B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Chemodectoma Malignant   Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibroma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    1/299(0.3%)            1/302(0.3%)
                         Mean(sd) 0.3%(0.8)              0.3%(0.8)
                         Range    0/50 - 1/50            0/50 - 1/52
   Males
   1/50  0/50  0/50  0/50  0/50  0/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Lipoma                   Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Liposarcoma              Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
===========================================================================

NOSE                                                            B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/49  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/49  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/49  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/49  0/50
---------------------------------------------------------------------------
===========================================================================

ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA)      B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Papilloma Squamous or    Total    0/299(0%)              1/302(0.3%)
Papilloma                Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/299(0%)              1/302(0.3%)
Carcinoma, Papilloma     Mean(sd) 0.0%(0.0)              0.3%(0.8)
Squamous, or Papilloma   Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
===========================================================================

ORAL MUCOSA                                                     B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Squamous Cell Carcinoma  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

OVARY                                                           B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Arrhenoblastoma Benign   Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Arrhenoblastoma NOS      Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Cystadenoma              Total                           15/301(5%)
                         Mean(sd)                        5.0%(2.7)
                         Range                           0/50 - 4/50
   Females
   3/52  2/49  0/50  3/50  4/50  3/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Granulosa Cell Tumor     Total                           1/301(0.3%)
Benign                   Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  0/49  0/50  0/50  1/50  0/50
---------------------------------------------------------------------------
Granulosa Cell Tumor     Total                           0/301(0%)
Malignant                Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Granulosa Cell Tumor:    Total                           1/301(0.3%)
Benign, Malignant, NOS   Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  0/49  0/50  0/50  1/50  0/50
---------------------------------------------------------------------------
Granulosa-Theca Tumor    Total                           1/301(0.3%)
Malignant                Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  0/49  0/50  0/50  1/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total                           3/301(1%)
                         Mean(sd)                        1.0%(2.5)
                         Range                           0/52 - 3/49
   Females
   0/52  3/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Liposarcoma              Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Luteoma                  Total                           1/301(0.3%)
                         Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  0/49  0/50  1/50  0/50  0/50
---------------------------------------------------------------------------
Teratoma                 Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Teratoma Benign          Total                           1/301(0.3%)
                         Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  0/49  1/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Teratoma Malignant       Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Teratoma NOS             Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Thecoma Benign           Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Tubulostromal Adenoma    Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Yolk Sac Carcinoma       Total                           0/301(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/49  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

PANCREAS                                                        B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/301(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
===========================================================================

PARATHYROID GLAND                                               B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Carcinoma                Total    0/262(0%)              0/243(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/47 - 0/47            0/43 - 0/43
   Males
   0/47  0/41  0/46  0/43  0/40  0/45
   Females
   0/43  0/43  0/38  0/37  0/44  0/38
---------------------------------------------------------------------------
===========================================================================

PHARYNX                                                         B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Squamous Cell Papilloma  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE              B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    1/287(0.3%)            44/297(14.8%)
                         Mean(sd) 0.3%(0.8)              14.9%(4.1)
                         Range    0/48 - 1/49            5/48 - 10/47
   Males
   0/48  0/48  1/49  0/45  0/48  0/49
   Females
   6/52  7/50  7/50  5/48  10/47 9/50
---------------------------------------------------------------------------
Carcinoma                Total    0/287(0%)              1/297(0.3%)
                         Mean(sd) 0.0%(0.0)              0.4%(0.9)
                         Range    0/48 - 0/48            0/52 - 1/48
   Males
   0/48  0/48  0/49  0/45  0/48  0/49
   Females
   0/52  0/50  0/50  1/48  0/47  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    1/287(0.3%)            45/297(15.2%)
                         Mean(sd) 0.3%(0.8)              15.2%(3.7)
                         Range    0/48 - 1/49            6/52 - 10/47
   Males
   0/48  0/48  1/49  0/45  0/48  0/49
   Females
   6/52  7/50  7/50  6/48  10/47 9/50
---------------------------------------------------------------------------
===========================================================================

PITUITARY GLAND: PARS INTERMEDIA                                B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    2/287(0.7%)            2/297(0.7%)
                         Mean(sd) 0.7%(1.1)              0.7%(1.0)
                         Range    0/48 - 1/45            0/52 - 1/50
   Males
   0/48  1/48  0/49  1/45  0/48  0/49
   Females
   0/52  1/50  1/50  0/48  0/47  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/287(0%)              0/297(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/48 - 0/48            0/52 - 0/52
   Males
   0/48  0/48  0/49  0/45  0/48  0/49
   Females
   0/52  0/50  0/50  0/48  0/47  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    2/287(0.7%)            2/297(0.7%)
                         Mean(sd) 0.7%(1.1)              0.7%(1.0)
                         Range    0/48 - 1/45            0/52 - 1/50
   Males
   0/48  1/48  0/49  1/45  0/48  0/49
   Females
   0/52  1/50  1/50  0/48  0/47  0/50
---------------------------------------------------------------------------
===========================================================================

PROSTATE                                                        B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Carcinoma                Total    0/298(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/298(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/298(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
===========================================================================

SALIVARY GLANDS                                                 B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Hemangioma               Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SEMINAL VESICLE                                                 B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
===========================================================================

SKELETAL MUSCLE                                                 B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrosarcoma             Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma             Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
Rhabdomyosarcoma         Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Rhabdomyosarcoma or      Total    0/299(0%)              0/302(0%)
Rhabdomyoma              Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SKIN1: SEBACEOUS GLAND                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  1/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SKIN2                                                           B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Basal Cell Adenoma       Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Adenoma or    Total    0/299(0%)              0/302(0%)
Basosquamous Tumor       Mean(sd) 0.0%(0.0)              0.0%(0.0)
Benign                   Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Adenoma,      Total    0/299(0%)              0/302(0%)
Basosquamous Tumor       Mean(sd) 0.0%(0.0)              0.0%(0.0)
Benign, or               Range    0/50 - 0/50            0/52 - 0/52
Trichoepithelioma
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Carcinoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Carcinoma     Total    0/299(0%)              0/302(0%)
or Basosquamous Tumor    Mean(sd) 0.0%(0.0)              0.0%(0.0)
(malignant or NOS)       Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Carcinoma,    Total    0/299(0%)              0/302(0%)
Basal Cell Adenoma,      Mean(sd) 0.0%(0.0)              0.0%(0.0)
Basosquamous Tumor       Range    0/50 - 0/50            0/52 - 0/52
(benign, malignant or
NOS), or
Trichoepithelioma
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Basal or Sq. Cell        Total    0/299(0%)              0/302(0%)
Carcinoma, Carcinoma,    Mean(sd) 0.0%(0.0)              0.0%(0.0)
Basosq. Tumor (M or B),  Range    0/50 - 0/50            0/52 - 0/52
Basal Cell Adenoma,
Adenoma, Papilloma, Sq
Papilloma,
Keratoacanthoma,
Trichoepithelioma
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Basosquamous Tumor       Total    0/299(0%)              0/302(0%)
Benign                   Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Basosquamous Tumor       Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    1/299(0.3%)            1/302(0.3%)
                         Mean(sd) 0.3%(0.8)              0.3%(0.8)
                         Range    0/50 - 1/50            0/50 - 1/52
   Males
   1/50  0/50  0/50  0/50  0/50  0/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    2/299(0.7%)            2/302(0.7%)
                         Mean(sd) 0.7%(1.0)              0.7%(1.0)
                         Range    0/50 - 1/50            0/52 - 1/50
   Males
   1/50  0/50  0/50  1/50  0/50  0/49
   Females
   0/52  1/50  0/50  0/50  1/50  0/50
---------------------------------------------------------------------------
Keratoacanthoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Lipoma                   Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Melanoma Benign          Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  1/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma             Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Paraganglioma Benign     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/299(0%)              0/302(0%)
Carcinoma, Basal Cell    Mean(sd) 0.0%(0.0)              0.0%(0.0)
Carcinoma, Basosquamous  Range    0/50 - 0/50            0/52 - 0/52
Tumor (malignant or
NOS), or Carcinoma
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/299(0%)              0/302(0%)
Papilloma or Papilloma   Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/299(0%)              0/302(0%)
Papilloma, Papilloma,    Mean(sd) 0.0%(0.0)              0.0%(0.0)
Squamous Cell Carcinoma  Range    0/50 - 0/50            0/52 - 0/52
or Keratoacanthoma
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/299(0%)              0/302(0%)
Papilloma, Papilloma, or Mean(sd) 0.0%(0.0)              0.0%(0.0)
Keratoacanthoma          Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Trichoepithelioma        Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SKIN3                                                           B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibroma                  Total    1/299(0.3%)            0/302(0%)
                         Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/50            0/52 - 0/52
   Males
   0/50  1/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibroma, Fibrosarcoma,   Total    2/299(0.7%)            9/302(3%)
Sarcoma, Myxoma,         Mean(sd) 0.7%(1.6)              3.0%(2.0)
Myxosarcoma, or Fibrous  Range    0/50 - 2/50            0/50 - 3/52
Histiocytoma
   Males
   0/50  2/50  0/50  0/50  0/50  0/49
   Females
   3/52  1/50  1/50  2/50  0/50  2/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    1/299(0.3%)            6/302(2%)
                         Mean(sd) 0.3%(0.8)              2.0%(1.7)
                         Range    0/50 - 1/50            0/50 - 2/50
   Males
   0/50  1/50  0/50  0/50  0/50  0/49
   Females
   2/52  0/50  1/50  1/50  0/50  2/50
---------------------------------------------------------------------------
Fibrosarcoma, Sarcoma,   Total    1/299(0.3%)            9/302(3%)
Myxosarcoma, or Fibrous  Mean(sd) 0.3%(0.8)              3.0%(2.0)
Histiocytoma             Range    0/50 - 1/50            0/50 - 3/52
   Males
   0/50  1/50  0/50  0/50  0/50  0/49
   Females
   3/52  1/50  1/50  2/50  0/50  2/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Myxosarcoma              Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/50 - 1/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Neurofibrosarcoma        Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Neurofibrosarcoma or     Total    0/299(0%)              0/302(0%)
Schwannoma (malignant or Mean(sd) 0.0%(0.0)              0.0%(0.0)
NOS)                     Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Neurofibrosarcoma,       Total    0/299(0%)              0/302(0%)
Neurofibroma, or         Mean(sd) 0.0%(0.0)              0.0%(0.0)
Schwannoma (benign,      Range    0/50 - 0/50            0/52 - 0/52
malignant or NOS)
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              3/302(1%)
                         Mean(sd) 0.0%(0.0)              1.0%(1.1)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   1/52  1/50  0/50  1/50  0/50  0/50
---------------------------------------------------------------------------
Schwannoma Malignant     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SPINAL CORD                                                     B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Schwannoma Malignant     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SPLEEN                                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrosarcoma             Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    11/299(3.7%)           5/302(1.7%)
                         Mean(sd) 3.7%(2.4)              1.7%(2.0)
                         Range    0/50 - 3/49            0/50 - 2/50
   Males
   0/50  1/50  2/50  3/50  2/50  3/49
   Females
   1/52  2/50  0/50  0/50  2/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/299(0%)              0/302(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    1/299(0.3%)            1/302(0.3%)
Malignant                Mean(sd) 0.3%(0.8)              0.3%(0.8)
                         Range    0/50 - 1/50            0/50 - 1/52
   Males
   0/50  1/50  0/50  0/50  0/50  0/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

STOMACH, FORESTOMACH                                            B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Hemangioma               Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor Benign   Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    1/299(0.3%)            1/302(0.3%)
                         Mean(sd) 0.3%(0.8)              0.3%(0.8)
                         Range    0/50 - 1/50            0/52 - 1/50
   Males
   0/50  1/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
Squamous Cell            Total    2/299(0.7%)            6/302(2%)
Carcinoma or Papilloma   Mean(sd) 0.7%(1.0)              2.0%(3.1)
Squamous                 Range    0/50 - 1/50            0/52 - 4/50
   Males
   0/50  1/50  1/50  0/50  0/50  0/49
   Females
   0/52  1/50  0/50  1/50  0/50  4/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total    1/299(0.3%)            5/302(1.7%)
                         Mean(sd) 0.3%(0.8)              1.7%(2.3)
                         Range    0/50 - 1/50            0/52 - 3/50
   Males
   0/50  0/50  1/50  0/50  0/50  0/49
   Females
   0/52  1/50  0/50  1/50  0/50  3/50
---------------------------------------------------------------------------
===========================================================================

STOMACH, GLANDULAR                                              B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

TESTES                                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    3/299(1%)
                         Mean(sd) 1.0%(1.7)
                         Range    0/50 - 2/50
   Males
   1/50  2/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
---------------------------------------------------------------------------
===========================================================================

THYMUS                                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrosarcoma             Total    0/238(0%)              0/265(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/31 - 0/31            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  0/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/238(0%)              0/265(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/31 - 0/31            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  0/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
Hemangioma               Total    1/238(0.4%)            0/265(0%)
                         Mean(sd) 0.4%(0.9)              0.0%(0.0)
                         Range    0/31 - 1/45            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  1/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/238(0%)              0/265(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/31 - 0/31            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  0/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/238(0%)              0/265(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/31 - 0/31            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  0/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
Sarcoma                  Total    0/238(0%)              0/265(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/31 - 0/31            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  0/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
Thymoma Benign           Total    0/238(0%)              0/265(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/31 - 0/31            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  0/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
Thymoma Malignant        Total    0/238(0%)              0/265(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/31 - 0/31            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  0/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
Thymoma NOS              Total    0/238(0%)              0/265(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/31 - 0/31            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  0/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
Thymoma: Benign,         Total    0/238(0%)              0/265(0%)
Malignant, NOS           Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/31 - 0/31            0/41 - 0/41
   Males
   0/31  0/37  0/37  0/43  0/45  0/45
   Females
   0/41  0/48  0/38  0/47  0/50  0/41
---------------------------------------------------------------------------
===========================================================================

THYROID GLAND: C-CELL                                           B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  1/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  1/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

THYROID GLAND: FOLLICULAR CELL                                  B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    9/299(3%)              17/302(5.6%)
                         Mean(sd) 3.0%(3.0)              5.6%(2.0)
                         Range    0/50 - 4/50            2/50 - 4/50
   Males
   0/50  4/50  2/50  0/50  1/50  2/49
   Females
   3/52  4/50  2/50  2/50  4/50  2/50
---------------------------------------------------------------------------
Carcinoma                Total    2/299(0.7%)            1/302(0.3%)
                         Mean(sd) 0.7%(1.0)              0.3%(0.8)
                         Range    0/50 - 1/50            0/50 - 1/52
   Males
   1/50  0/50  0/50  0/50  0/50  1/49
   Females
   1/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    11/299(3.7%)           18/302(6%)
                         Mean(sd) 3.7%(3.0)              6.0%(2.1)
                         Range    0/50 - 4/50            2/50 - 4/50
   Males
   1/50  4/50  2/50  0/50  1/50  3/49
   Females
   4/52  4/50  2/50  2/50  4/50  2/50
---------------------------------------------------------------------------
===========================================================================

TISSUE NOS                                                      B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Fibrosarcoma             Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Lipoma                   Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Rhabdomyosarcoma         Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

TONGUE                                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Squamous Cell Carcinoma  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/299(0%)              1/302(0.3%)
Carcinoma or Papilloma   Mean(sd) 0.0%(0.0)              0.3%(0.8)
Squamous                 Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total    0/299(0%)              1/302(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/52 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
===========================================================================

TOOTH                                                           B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adamantinoma Benign      Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Odontoma                 Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

URINARY BLADDER                                                 B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Carcinoma or Papilloma   Total    0/299(0%)              0/300(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/50  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/299(0%)              1/300(0.3%)
                         Mean(sd) 0.0%(0.0)              0.3%(0.8)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/50  0/50  0/50  1/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/299(0%)              0/300(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/50  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    1/299(0.3%)            0/300(0%)
                         Mean(sd) 0.3%(0.8)              0.0%(0.0)
                         Range    0/50 - 1/49            0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  1/49
   Females
   0/50  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Papilloma                Total    0/299(0%)              0/300(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/50  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

UTERUS                                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total                           1/302(0.3%)
                         Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  1/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total                           1/302(0.3%)
                         Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
Deciduoma Benign         Total                           0/302(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Granular Cell Tumor      Total                           0/302(0%)
Benign                   Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total                           1/302(0.3%)
                         Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  0/50  0/50  1/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total                           0/302(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyoma                Total                           0/302(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total                           1/302(0.3%)
                         Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  0/50  0/50  1/50  0/50  0/50
---------------------------------------------------------------------------
Polyp Stromal            Total                           11/302(3.6%)
                         Mean(sd)                        3.7%(2.0)
                         Range                           1/52 - 3/50
   Females
   1/52  3/50  3/50  1/50  2/50  1/50
---------------------------------------------------------------------------
Sarcoma                  Total                           0/302(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma Stromal          Total                           1/302(0.3%)
                         Mean(sd)                        0.3%(0.8)
                         Range                           0/52 - 1/50
   Females
   0/52  0/50  0/50  0/50  0/50  1/50
---------------------------------------------------------------------------
Sarcoma Stromal or       Total                           12/302(4%)
Polyp Stromal            Mean(sd)                        4.0%(1.8)
                         Range                           1/52 - 3/50
   Females
   1/52  3/50  3/50  1/50  2/50  2/50
---------------------------------------------------------------------------
===========================================================================

VAGINA                                                          B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Leiomyosarcoma           Total                           0/302(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total                           0/302(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total                           0/302(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/52 - 0/52
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ZYMBAL'S GLAND                                                  B6C3F1 MICE
                                  DERMAL ETHANOL
(Updated 12/99)                 Males(6 studies)      Females(6 studies)
===========================================================================
Adenoma                  Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/299(0%)              0/302(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/52 - 0/52
   Males
   0/50  0/50  0/50  0/50  0/50  0/49
   Females
   0/52  0/50  0/50  0/50  0/50  0/50
---------------------------------------------------------------------------