TOXICOLOGY DATA MANAGEMENT SYSTEM
                 HISTORICAL CONTROL TUMOR INCIDENCE SUMMARY
===========================================================================

ALL ORGANS                                                      B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Benign Tumors            Total    86/150(57.3%)          88/150(58.7%)
                         Mean(sd) 57.3%(21.9)            58.7%(16.2)
                         Range    16/50 - 35/50          20/50 - 34/50
   Males
   35/50 16/50 35/50
   Females
   34/50 20/50 34/50
---------------------------------------------------------------------------
Malignant Tumors         Total    60/150(40%)            59/150(39.3%)
                         Mean(sd) 40.0%(3.5)             39.3%(20.5)
                         Range    19/50 - 22/50          11/50 - 31/50
   Males
   22/50 19/50 19/50
   Females
   31/50 17/50 11/50
---------------------------------------------------------------------------
Malignant and Benign     Total    108/150(72%)           114/150(76%)
Tumors                   Mean(sd) 72.0%(15.9)            76.0%(15.1)
                         Range    27/50 - 42/50          31/50 - 46/50
   Males
   42/50 27/50 39/50
   Females
   46/50 31/50 37/50
---------------------------------------------------------------------------
Hemangioma               Total    3/150(2%)              1/150(0.7%)
                         Mean(sd) 2.0%(2.0)              0.7%(1.2)
                         Range    0/50 - 2/50            0/50 - 1/50
   Males
   2/50  0/50  1/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    16/150(10.7%)          9/150(6%)
                         Mean(sd) 10.7%(8.3)             6.0%(3.5)
                         Range    2/50 - 10/50           1/50 - 4/50
   Males
   4/50  10/50 2/50
   Females
   4/50  1/50  4/50
---------------------------------------------------------------------------
Hemangiosarcoma or       Total    19/150(12.7%)          10/150(6.7%)
Hemangioma               Mean(sd) 12.7%(7.0)             6.7%(2.3)
                         Range    3/50 - 10/50           2/50 - 4/50
   Males
   6/50  10/50 3/50
   Females
   4/50  2/50  4/50
---------------------------------------------------------------------------
Histiocytic Sarcoma      Total    1/150(0.7%)            4/150(2.7%)
                         Mean(sd) 0.7%(1.2)              2.7%(4.6)
                         Range    0/50 - 1/50            0/50 - 4/50
   Males
   1/50  0/50  0/50
   Females
   4/50  0/50  0/50
---------------------------------------------------------------------------
Leukemia: Erythrocytic   Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leukemia: Granulocytic   Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leukemia: Lymphocytic,   Total    0/150(0%)              1/150(0.7%)
Monocytic, Mononuclear,  Mean(sd) 0.0%(0.0)              0.7%(1.2)
or Undifferentiated      Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Malignant Lymphoma:      Total    10/150(6.7%)           22/150(14.7%)
Histiocytic,             Mean(sd) 6.7%(1.2)              14.7%(4.6)
Lymphocytic, Mixed, NOS, Range    3/50 - 4/50            6/50 - 10/50
or Undifferentiated Cell
Type
   Males
   3/50  3/50  4/50
   Females
   10/50 6/50  6/50
---------------------------------------------------------------------------
Osteoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma or Osteoma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ADRENAL CORTEX                                                  B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    9/149(6%)              5/148(3.4%)
                         Mean(sd) 6.0%(8.7)              3.4%(1.2)
                         Range    0/49 - 8/50            1/50 - 2/48
   Males
   0/49  8/50  1/50
   Females
   2/48  2/50  1/50
---------------------------------------------------------------------------
Carcinoma                Total    0/149(0%)              0/148(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/48 - 0/48
   Males
   0/49  0/50  0/50
   Females
   0/48  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/99(0%)               0/136(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/48 - 0/48
   Males
   0/49  0/0   0/50
   Females
   0/48  0/38  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    0/99(0%)               0/136(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/48 - 0/48
   Males
   0/49  0/0   0/50
   Females
   0/48  0/38  0/50
---------------------------------------------------------------------------
===========================================================================

ADRENAL GLAND: NON-MEDULLARY, NON-CORTICAL                      B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/149(0%)              0/148(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/48 - 0/48
   Males
   0/49  0/50  0/50
   Females
   0/48  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ADRENAL MEDULLA                                                 B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Pheochromocytoma Benign  Total    2/148(1.4%)            5/148(3.4%)
                         Mean(sd) 1.4%(1.2)              3.4%(4.1)
                         Range    0/50 - 1/48            0/50 - 4/50
   Males
   1/48  0/50  1/50
   Females
   1/48  4/50  0/50
---------------------------------------------------------------------------
Pheochromocytoma Complex Total    0/148(0%)              0/148(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/48 - 0/48            0/48 - 0/48
   Males
   0/48  0/50  0/50
   Females
   0/48  0/50  0/50
---------------------------------------------------------------------------
Pheochromocytoma         Total    0/148(0%)              1/148(0.7%)
Malignant                Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/48 - 0/48            0/50 - 1/48
   Males
   0/48  0/50  0/50
   Females
   1/48  0/50  0/50
---------------------------------------------------------------------------
Pheochromocytoma:        Total    2/148(1.4%)            6/148(4.1%)
Benign, Complex,         Mean(sd) 1.4%(1.2)              4.1%(4.0)
Malignant, NOS           Range    0/50 - 1/48            0/50 - 4/50
   Males
   1/48  0/50  1/50
   Females
   2/48  4/50  0/50
---------------------------------------------------------------------------
===========================================================================

BONE MARROW                                                     B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/149(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/149(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    2/149(1.3%)            2/150(1.3%)
                         Mean(sd) 1.4%(2.4)              1.3%(1.2)
                         Range    0/50 - 2/49            0/50 - 1/50
   Males
   2/49  0/50  0/50
   Females
   1/50  0/50  1/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/149(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor NOS      Total    0/149(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    0/149(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

BONE                                                            B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Osteoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma or Osteoma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

BRAIN                                                           B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Astrocytoma Benign       Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Meningioma Malignant     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Meningioma: Benign,      Total    0/150(0%)              0/150(0%)
Malignant, NOS           Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Oligodendroglioma Benign Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Oligodendroglioma        Total    0/150(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Oligodendroglioma,       Total    0/150(0%)              0/150(0%)
Glioma, or Astrocytoma   Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

CLITORAL/PREPUTIAL GLAND                                        B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

EAR                                                             B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Basosquamous Tumor       Total    0/150(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibroma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

EPIDIDYMIS                                                      B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/149(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/149(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50
---------------------------------------------------------------------------
Leiomyoma                Total    0/149(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    1/149(0.7%)
                         Mean(sd) 0.7%(1.2)
                         Range    0/49 - 1/50
   Males
   0/49  1/50  0/50
---------------------------------------------------------------------------
===========================================================================

ESOPHAGUS                                                       B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

EYE                                                             B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

GALLBLADDER                                                     B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/140(0%)              0/140(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/46 - 0/46            0/43 - 0/43
   Males
   0/46  0/44  0/50
   Females
   0/43  0/47  0/50
---------------------------------------------------------------------------
===========================================================================

HARDERIAN GLAND                                                 B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    7/150(4.7%)            2/150(1.3%)
                         Mean(sd) 4.7%(4.2)              1.3%(1.2)
                         Range    0/50 - 4/50            0/50 - 1/50
   Males
   3/50  0/50  4/50
   Females
   0/50  1/50  1/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    7/150(4.7%)            2/150(1.3%)
                         Mean(sd) 4.7%(4.2)              1.3%(1.2)
                         Range    0/50 - 4/50            0/50 - 1/50
   Males
   3/50  0/50  4/50
   Females
   0/50  1/50  1/50
---------------------------------------------------------------------------
===========================================================================

HEART                                                           B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   1/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              1/150(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   1/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE LARGE: CECUM                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE LARGE: COLON/RECTUM                                   B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE SMALL: DUODENUM                                       B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Polyp Adenomatous        Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE SMALL: ILEUM                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE SMALL: JEJUNUM                                        B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Polyp Adenomatous        Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

INTESTINE SMALL: SITE UNSPECIFIED                               B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Polyp Adenomatous        Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ISLETS, PANCREATIC                                              B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    1/149(0.7%)            1/149(0.7%)
                         Mean(sd) 0.7%(1.2)              0.7%(1.2)
                         Range    0/49 - 1/50            0/50 - 1/49
   Males
   0/49  0/50  1/50
   Females
   1/49  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/149(0%)              2/149(1.3%)
                         Mean(sd) 0.0%(0.0)              1.3%(2.3)
                         Range    0/49 - 0/49            0/49 - 2/50
   Males
   0/49  0/50  0/50
   Females
   0/49  2/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    1/149(0.7%)            3/149(2%)
                         Mean(sd) 0.7%(1.2)              2.0%(2.0)
                         Range    0/49 - 1/50            0/50 - 2/50
   Males
   0/49  0/50  1/50
   Females
   1/49  2/50  0/50
---------------------------------------------------------------------------
===========================================================================

KIDNEY: PELVIS AND TRANSITIONAL EPITHELIUM                      B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

KIDNEY: RENAL TUBULE                                            B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    1/150(0.7%)            1/150(0.7%)
                         Mean(sd) 0.7%(1.2)              0.7%(1.2)
                         Range    0/50 - 1/50            0/50 - 1/50
   Males
   1/50  0/50  0/50
   Females
   1/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    2/150(1.3%)            1/150(0.7%)
                         Mean(sd) 1.3%(1.2)              0.7%(1.2)
                         Range    0/50 - 1/50            0/50 - 1/50
   Males
   1/50  0/50  1/50
   Females
   1/50  0/50  0/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LIVER                                                           B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Cholangiocarcinoma       Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Cholangioma              Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/150(0%)              1/150(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    6/150(4%)              2/150(1.3%)
                         Mean(sd) 4.0%(2.0)              1.3%(2.3)
                         Range    1/50 - 3/50            0/50 - 2/50
   Males
   3/50  1/50  2/50
   Females
   2/50  0/50  0/50
---------------------------------------------------------------------------
Hepatoblastoma           Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hepatocellular Adenoma   Total    57/150(38%)            56/150(37.3%)
                         Mean(sd) 38.0%(22.7)            37.3%(26.6)
                         Range    6/50 - 27/50           4/50 - 30/50
   Males
   24/50 6/50  27/50
   Females
   30/50 4/50  22/50
---------------------------------------------------------------------------
Hepatocellular Carcinoma Total    27/150(18%)            18/150(12%)
                         Mean(sd) 18.0%(11.1)            12.0%(12.5)
                         Range    4/50 - 15/50           1/50 - 13/50
   Males
   8/50  4/50  15/50
   Females
   13/50 4/50  1/50
---------------------------------------------------------------------------
Hepatocellular           Total    27/150(18%)            18/150(12%)
Carcinoma or             Mean(sd) 18.0%(11.1)            12.0%(12.5)
Hepatoblastoma           Range    4/50 - 15/50           1/50 - 13/50
   Males
   8/50  4/50  15/50
   Females
   13/50 4/50  1/50
---------------------------------------------------------------------------
Hepatocellular           Total    67/150(44.7%)          63/150(42%)
Carcinoma or             Mean(sd) 44.7%(23.4)            42.0%(26.2)
Hepatocellular Adenoma   Range    9/50 - 31/50           7/50 - 33/50
   Males
   27/50 9/50  31/50
   Females
   33/50 7/50  23/50
---------------------------------------------------------------------------
Hepatocellular           Total    67/150(44.7%)          63/150(42%)
Carcinoma,               Mean(sd) 44.7%(23.4)            42.0%(26.2)
Hepatocellular Adenoma,  Range    9/50 - 31/50           7/50 - 33/50
or Hepatoblastoma
   Males
   27/50 9/50  31/50
   Females
   33/50 7/50  23/50
---------------------------------------------------------------------------
Hepatocholangiocarcinoma Total    0/150(0%)              1/150(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Ito Cell Tumor Benign    Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Ito Cell Tumor Malignant Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Ito Cell Tumor NOS       Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/150(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    0/150(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LUNG                                                            B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Alveolar/Bronchiolar     Total    32/150(21.3%)          5/150(3.3%)
Adenoma                  Mean(sd) 21.3%(10.3)            3.3%(1.2)
                         Range    5/50 - 15/50           1/50 - 2/50
   Males
   12/50 5/50  15/50
   Females
   1/50  2/50  2/50
---------------------------------------------------------------------------
Alveolar/Bronchiolar     Total    14/150(9.3%)           5/150(3.3%)
Carcinoma                Mean(sd) 9.3%(5.0)              3.3%(3.1)
                         Range    2/50 - 7/50            0/50 - 3/50
   Males
   7/50  5/50  2/50
   Females
   3/50  2/50  0/50
---------------------------------------------------------------------------
Alveolar/Bronchiolar     Total    42/150(28%)            10/150(6.7%)
Carcinoma or             Mean(sd) 28.0%(10.6)            6.7%(2.3)
Alveolar/Bronchiolar     Range    8/50 - 18/50           2/50 - 4/50
Adenoma
   Males
   18/50 8/50  16/50
   Females
   4/50  4/50  2/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  1/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/150(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LYMPH NODE, MANDIBULAR                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LYMPH NODE, MESENTERIC                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    0/150(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LYMPH NODE                                                      B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Liposarcoma              Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    0/150(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

LYMPH NODE: MESENTERIC                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

MAMMARY GLAND                                                   B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)              1/150(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/150(0%)              1/150(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Fibroma, Fibroadenoma    Total    0/150(0%)              0/150(0%)
or Adenoma               Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibroma, Fibroadenoma,   Total    0/150(0%)              1/150(0.7%)
Carcinoma, or Adenoma    Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              1/150(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  1/50
---------------------------------------------------------------------------
Myoepithelioma           Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

MESENTERY                                                       B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Chemodectoma Malignant   Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibroma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Lipoma                   Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Liposarcoma              Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

NOSE                                                            B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ORAL CAVITY (ORAL MUCOSA, TONGUE, PHARYNX, TOOTH, GINGIVA)      B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Papilloma Squamous or    Total    0/150(0%)              0/150(0%)
Papilloma                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/150(0%)              0/150(0%)
Carcinoma, Papilloma     Mean(sd) 0.0%(0.0)              0.0%(0.0)
Squamous, or Papilloma   Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ORAL MUCOSA                                                     B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Squamous Cell Carcinoma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

OVARY                                                           B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Arrhenoblastoma Benign   Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Arrhenoblastoma NOS      Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Carcinoma                Total                           1/149(0.7%)
                         Mean(sd)                        0.7%(1.2)
                         Range                           0/49 - 1/50
   Females
   1/50  0/49  0/50
---------------------------------------------------------------------------
Cystadenoma              Total                           9/149(6%)
                         Mean(sd)                        6.0%(4.0)
                         Range                           1/50 - 5/50
   Females
   1/50  3/49  5/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Granulosa Cell Tumor     Total                           1/149(0.7%)
Benign                   Mean(sd)                        0.7%(1.2)
                         Range                           0/50 - 1/50
   Females
   0/50  0/49  1/50
---------------------------------------------------------------------------
Granulosa Cell Tumor     Total                           1/149(0.7%)
Malignant                Mean(sd)                        0.7%(1.2)
                         Range                           0/50 - 1/49
   Females
   0/50  1/49  0/50
---------------------------------------------------------------------------
Granulosa Cell Tumor:    Total                           2/149(1.3%)
Benign, Malignant, NOS   Mean(sd)                        1.3%(1.2)
                         Range                           0/50 - 1/49
   Females
   0/50  1/49  1/50
---------------------------------------------------------------------------
Granulosa-Theca Tumor    Total                           0/149(0%)
Malignant                Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Hemangioma               Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total                           1/149(0.7%)
                         Mean(sd)                        0.7%(1.2)
                         Range                           0/50 - 1/50
   Females
   0/50  0/49  1/50
---------------------------------------------------------------------------
Liposarcoma              Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Luteoma                  Total                           3/149(2%)
                         Mean(sd)                        2.0%(3.5)
                         Range                           0/50 - 3/50
   Females
   0/50  0/49  3/50
---------------------------------------------------------------------------
Teratoma                 Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Teratoma Benign          Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Teratoma Malignant       Total                           1/149(0.7%)
                         Mean(sd)                        0.7%(1.2)
                         Range                           0/50 - 1/49
   Females
   0/50  1/49  0/50
---------------------------------------------------------------------------
Teratoma NOS             Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Thecoma Benign           Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Tubulostromal Adenoma    Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Yolk Sac Carcinoma       Total                           0/149(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
===========================================================================

PANCREAS                                                        B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
===========================================================================

PARATHYROID GLAND                                               B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Carcinoma                Total    0/133(0%)              0/130(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/37 - 0/37            0/40 - 0/40
   Males
   0/37  0/49  0/47
   Females
   0/40  0/47  0/43
---------------------------------------------------------------------------
===========================================================================

PHARYNX                                                         B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Squamous Cell Papilloma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

PITUITARY GLAND: PARS DISTALIS OR UNSPECIFIED SITE              B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/141(0%)              15/137(10.9%)
                         Mean(sd) 0.0%(0.0)              10.9%(1.6)
                         Range    0/45 - 0/45            4/44 - 6/49
   Males
   0/45  0/48  0/48
   Females
   5/44  6/49  4/44
---------------------------------------------------------------------------
Carcinoma                Total    0/141(0%)              0/137(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/45 - 0/45            0/44 - 0/44
   Males
   0/45  0/48  0/48
   Females
   0/44  0/49  0/44
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/141(0%)              15/137(10.9%)
                         Mean(sd) 0.0%(0.0)              10.9%(1.6)
                         Range    0/45 - 0/45            4/44 - 6/49
   Males
   0/45  0/48  0/48
   Females
   5/44  6/49  4/44
---------------------------------------------------------------------------
===========================================================================

PITUITARY GLAND: PARS INTERMEDIA                                B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/141(0%)              0/137(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/45 - 0/45            0/44 - 0/44
   Males
   0/45  0/48  0/48
   Females
   0/44  0/49  0/44
---------------------------------------------------------------------------
Carcinoma                Total    0/141(0%)              0/137(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/45 - 0/45            0/44 - 0/44
   Males
   0/45  0/48  0/48
   Females
   0/44  0/49  0/44
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/141(0%)              0/137(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/45 - 0/45            0/44 - 0/44
   Males
   0/45  0/48  0/48
   Females
   0/44  0/49  0/44
---------------------------------------------------------------------------
===========================================================================

PROSTATE                                                        B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Carcinoma                Total    0/149(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/149(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/149(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SALIVARY GLANDS                                                 B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Hemangioma               Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SEMINAL VESICLE                                                 B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/150(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/50 - 0/50
   Males
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SKELETAL MUSCLE                                                 B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Rhabdomyosarcoma         Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Rhabdomyosarcoma or      Total    0/150(0%)              0/150(0%)
Rhabdomyoma              Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SKIN1: SEBACEOUS GLAND                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SKIN2                                                           B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Basal Cell Adenoma       Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Adenoma or    Total    0/150(0%)              0/150(0%)
Basosquamous Tumor       Mean(sd) 0.0%(0.0)              0.0%(0.0)
Benign                   Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Adenoma,      Total    0/150(0%)              0/150(0%)
Basosquamous Tumor       Mean(sd) 0.0%(0.0)              0.0%(0.0)
Benign, or               Range    0/50 - 0/50            0/50 - 0/50
Trichoepithelioma
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Carcinoma     Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Carcinoma     Total    1/150(0.7%)            0/150(0%)
or Basosquamous Tumor    Mean(sd) 0.7%(1.2)              0.0%(0.0)
(malignant or NOS)       Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Basal Cell Carcinoma,    Total    1/150(0.7%)            0/150(0%)
Basal Cell Adenoma,      Mean(sd) 0.7%(1.2)              0.0%(0.0)
Basosquamous Tumor       Range    0/50 - 1/50            0/50 - 0/50
(benign, malignant or
NOS), or
Trichoepithelioma
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Basal or Sq. Cell        Total    1/150(0.7%)            0/150(0%)
Carcinoma, Carcinoma,    Mean(sd) 0.7%(1.2)              0.0%(0.0)
Basosq. Tumor (M or B),  Range    0/50 - 1/50            0/50 - 0/50
Basal Cell Adenoma,
Adenoma, Papilloma, Sq
Papilloma,
Keratoacanthoma,
Trichoepithelioma
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Basosquamous Tumor       Total    0/150(0%)              0/150(0%)
Benign                   Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Basosquamous Tumor       Total    0/150(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    2/150(1.3%)            0/150(0%)
                         Mean(sd) 1.3%(2.3)              0.0%(0.0)
                         Range    0/50 - 2/50            0/50 - 0/50
   Males
   0/50  2/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Keratoacanthoma          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Lipoma                   Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/150(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Melanoma Benign          Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Osteosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Paraganglioma Benign     Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  1/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    1/150(0.7%)            0/150(0%)
Carcinoma, Basal Cell    Mean(sd) 0.7%(1.2)              0.0%(0.0)
Carcinoma, Basosquamous  Range    0/50 - 1/50            0/50 - 0/50
Tumor (malignant or
NOS), or Carcinoma
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/150(0%)              0/150(0%)
Papilloma or Papilloma   Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/150(0%)              0/150(0%)
Papilloma, Papilloma,    Mean(sd) 0.0%(0.0)              0.0%(0.0)
Squamous Cell Carcinoma  Range    0/50 - 0/50            0/50 - 0/50
or Keratoacanthoma
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/150(0%)              0/150(0%)
Papilloma, Papilloma, or Mean(sd) 0.0%(0.0)              0.0%(0.0)
Keratoacanthoma          Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Trichoepithelioma        Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SKIN3                                                           B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibroma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibroma, Fibrosarcoma,   Total    0/150(0%)              4/150(2.7%)
Sarcoma, Myxoma,         Mean(sd) 0.0%(0.0)              2.7%(1.2)
Myxosarcoma, or Fibrous  Range    0/50 - 0/50            1/50 - 2/50
Histiocytoma
   Males
   0/50  0/50  0/50
   Females
   2/50  1/50  1/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/150(0%)              1/150(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Fibrosarcoma, Sarcoma,   Total    0/150(0%)              4/150(2.7%)
Myxosarcoma, or Fibrous  Mean(sd) 0.0%(0.0)              2.7%(1.2)
Histiocytoma             Range    0/50 - 0/50            1/50 - 2/50
   Males
   0/50  0/50  0/50
   Females
   2/50  1/50  1/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Myxosarcoma              Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Neurofibrosarcoma        Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Neurofibrosarcoma or     Total    0/150(0%)              0/150(0%)
Schwannoma (malignant or Mean(sd) 0.0%(0.0)              0.0%(0.0)
NOS)                     Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Neurofibrosarcoma,       Total    0/150(0%)              0/150(0%)
Neurofibroma, or         Mean(sd) 0.0%(0.0)              0.0%(0.0)
Schwannoma (benign,      Range    0/50 - 0/50            0/50 - 0/50
malignant or NOS)
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              3/150(2%)
                         Mean(sd) 0.0%(0.0)              2.0%(2.0)
                         Range    0/50 - 0/50            0/50 - 2/50
   Males
   0/50  0/50  0/50
   Females
   2/50  0/50  1/50
---------------------------------------------------------------------------
Schwannoma Malignant     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SPINAL CORD                                                     B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Hemangiosarcoma          Total    0/150(0%)              1/150(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   1/50  0/50  0/50
---------------------------------------------------------------------------
Schwannoma Malignant     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

SPLEEN                                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrosarcoma             Total    0/148(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/48 - 0/48            0/50 - 0/50
   Males
   0/48  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/148(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/48 - 0/48            0/50 - 0/50
   Males
   0/48  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/148(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/48 - 0/48            0/50 - 0/50
   Males
   0/48  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    9/148(6.1%)            4/150(2.7%)
                         Mean(sd) 6.1%(5.3)              2.7%(3.1)
                         Range    1/50 - 6/50            0/50 - 3/50
   Males
   2/48  6/50  1/50
   Females
   1/50  0/50  3/50
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/148(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/48 - 0/48            0/50 - 0/50
   Males
   0/48  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Plasma Cell Tumor        Total    0/148(0%)              0/150(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/48 - 0/48            0/50 - 0/50
   Males
   0/48  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

STOMACH, FORESTOMACH                                            B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Hemangioma               Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Mast Cell Tumor Benign   Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total    2/150(1.3%)            0/150(0%)
                         Mean(sd) 1.3%(2.3)              0.0%(0.0)
                         Range    0/50 - 2/50            0/50 - 0/50
   Males
   2/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    2/150(1.3%)            2/150(1.3%)
Carcinoma or Papilloma   Mean(sd) 1.3%(2.3)              1.3%(1.2)
Squamous                 Range    0/50 - 2/50            0/50 - 1/50
   Males
   2/50  0/50  0/50
   Females
   1/50  1/50  0/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total    0/150(0%)              2/150(1.3%)
                         Mean(sd) 0.0%(0.0)              1.3%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   1/50  1/50  0/50
---------------------------------------------------------------------------
===========================================================================

STOMACH, GLANDULAR                                              B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Fibrosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

TESTES                                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    1/149(0.7%)
                         Mean(sd) 0.7%(1.2)
                         Range    0/50 - 1/49
   Males
   1/49  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    0/149(0%)
                         Mean(sd) 0.0%(0.0)
                         Range    0/49 - 0/49
   Males
   0/49  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

THYMUS                                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrosarcoma             Total    0/112(0%)              0/132(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/39 - 0/39            0/45 - 0/45
   Males
   0/39  0/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
Fibrous Histiocytoma     Total    0/112(0%)              0/132(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/39 - 0/39            0/45 - 0/45
   Males
   0/39  0/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
Hemangioma               Total    0/112(0%)              0/132(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/39 - 0/39            0/45 - 0/45
   Males
   0/39  0/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
Hemangiosarcoma          Total    1/112(0.9%)            0/132(0%)
                         Mean(sd) 1.1%(2.0)              0.0%(0.0)
                         Range    0/39 - 1/29            0/45 - 0/45
   Males
   0/39  1/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
Mast Cell Tumor          Total    0/112(0%)              0/132(0%)
Malignant                Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/39 - 0/39            0/45 - 0/45
   Males
   0/39  0/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
Sarcoma                  Total    0/112(0%)              0/132(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/39 - 0/39            0/45 - 0/45
   Males
   0/39  0/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
Thymoma Benign           Total    0/112(0%)              0/132(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/39 - 0/39            0/45 - 0/45
   Males
   0/39  0/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
Thymoma Malignant        Total    0/112(0%)              0/132(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/39 - 0/39            0/45 - 0/45
   Males
   0/39  0/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
Thymoma NOS              Total    1/112(0.9%)            0/132(0%)
                         Mean(sd) 0.9%(1.5)              0.0%(0.0)
                         Range    0/29 - 1/39            0/45 - 0/45
   Males
   1/39  0/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
Thymoma: Benign,         Total    1/112(0.9%)            0/132(0%)
Malignant, NOS           Mean(sd) 0.9%(1.5)              0.0%(0.0)
                         Range    0/29 - 1/39            0/45 - 0/45
   Males
   1/39  0/29  0/44
   Females
   0/45  0/41  0/46
---------------------------------------------------------------------------
===========================================================================

THYROID GLAND: C-CELL                                           B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/149(0%)              1/149(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/49 - 0/49            0/50 - 1/49
   Males
   0/49  0/50  0/50
   Females
   1/49  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/149(0%)              1/149(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/49 - 0/49            0/50 - 1/49
   Males
   0/49  0/50  0/50
   Females
   1/49  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/149(0%)              2/149(1.3%)
                         Mean(sd) 0.0%(0.0)              1.4%(2.4)
                         Range    0/49 - 0/49            0/50 - 2/49
   Males
   0/49  0/50  0/50
   Females
   2/49  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

THYROID GLAND: FOLLICULAR CELL                                  B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    4/149(2.7%)            5/149(3.4%)
                         Mean(sd) 2.7%(2.3)              3.3%(4.2)
                         Range    0/49 - 2/50            0/49 - 4/50
   Males
   0/49  2/50  2/50
   Females
   0/49  1/50  4/50
---------------------------------------------------------------------------
Carcinoma                Total    1/149(0.7%)            0/149(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/49            0/49 - 0/49
   Males
   1/49  0/50  0/50
   Females
   0/49  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    5/149(3.4%)            5/149(3.4%)
                         Mean(sd) 3.3%(1.2)              3.3%(4.2)
                         Range    1/49 - 2/50            0/49 - 4/50
   Males
   1/49  2/50  2/50
   Females
   0/49  1/50  4/50
---------------------------------------------------------------------------
===========================================================================

TISSUE NOS                                                      B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Fibrosarcoma             Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  0/50  1/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/150(0%)              1/150(0.7%)
                         Mean(sd) 0.0%(0.0)              0.7%(1.2)
                         Range    0/50 - 0/50            0/50 - 1/50
   Males
   0/50  0/50  0/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Leiomyoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Lipoma                   Total    1/150(0.7%)            0/150(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/50            0/50 - 0/50
   Males
   0/50  1/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Rhabdomyosarcoma         Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

TONGUE                                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Squamous Cell Carcinoma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell            Total    0/150(0%)              0/150(0%)
Carcinoma or Papilloma   Mean(sd) 0.0%(0.0)              0.0%(0.0)
Squamous                 Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

TOOTH                                                           B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adamantinoma Benign      Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Odontoma                 Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

URINARY BLADDER                                                 B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Carcinoma or Papilloma   Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Hemangioma               Total    1/149(0.7%)            0/149(0%)
                         Mean(sd) 0.7%(1.2)              0.0%(0.0)
                         Range    0/50 - 1/49            0/50 - 0/50
   Males
   1/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
Papilloma                Total    0/149(0%)              0/149(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/49 - 0/49            0/50 - 0/50
   Males
   0/49  0/50  0/50
   Females
   0/50  0/49  0/50
---------------------------------------------------------------------------
===========================================================================

UTERUS                                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Deciduoma Benign         Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Granular Cell Tumor      Total                           0/150(0%)
Benign                   Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangioma               Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Hemangiosarcoma          Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyoma                Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Leiomyosarcoma           Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Polyp Stromal            Total                           4/150(2.7%)
                         Mean(sd)                        2.7%(3.1)
                         Range                           0/50 - 3/50
   Females
   0/50  3/50  1/50
---------------------------------------------------------------------------
Sarcoma                  Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Sarcoma Stromal          Total                           1/150(0.7%)
                         Mean(sd)                        0.7%(1.2)
                         Range                           0/50 - 1/50
   Females
   0/50  1/50  0/50
---------------------------------------------------------------------------
Sarcoma Stromal or       Total                           5/150(3.3%)
Polyp Stromal            Mean(sd)                        3.3%(4.2)
                         Range                           0/50 - 4/50
   Females
   0/50  4/50  1/50
---------------------------------------------------------------------------
===========================================================================

VAGINA                                                          B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Leiomyosarcoma           Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Carcinoma  Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Squamous Cell Papilloma  Total                           0/150(0%)
                         Mean(sd)                        0.0%(0.0)
                         Range                           0/50 - 0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
===========================================================================

ZYMBAL'S GLAND                                                  B6C3F1 MICE
                                  DERMAL ACETONE
(Updated 12/99)                 Males(3 studies)      Females(3 studies)
===========================================================================
Adenoma                  Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma                Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------
Carcinoma or Adenoma     Total    0/150(0%)              0/150(0%)
                         Mean(sd) 0.0%(0.0)              0.0%(0.0)
                         Range    0/50 - 0/50            0/50 - 0/50
   Males
   0/50  0/50  0/50
   Females
   0/50  0/50  0/50
---------------------------------------------------------------------------