NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 1
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                                                                           TIME: 08:57:27

                                                         EIS REPORT 37

       FACILITY:  BIORELIANCE

       NTP C#:  C95003

       CONTRACT NUMBER:  N01-ES-75408

       CAS NUMBER:  1896-62-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 2
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 7                      ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: VEHICLE CONTROL    PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 3
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 19                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: CONTROL SPECIAL    PROCEDURE SET:      4
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 4
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 8                      ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 22.0    MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 5
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 20                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 22.0    MG/KG      PROCEDURE SET:      4
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 6
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 9                      ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 44.0    MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 7
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 21                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 44.0    MG/KG      PROCEDURE SET:      4
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 8
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 10                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 87.5    MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

91           91   93 03/13/02    93 03/13/02   1/14  Thickened Site Of Application

  REMOVED  **  CID    91 **   REASON - TSAC
                                 93 03/13/02         Thickened Site Of Application

93           93   93 03/13/02    93 03/13/02   1/14  Irritation Site Of Application

  REMOVED  **  CID    93 **   REASON - TSAC
                                 93 03/13/02         Irritation Site Of Application

99           99   93 03/13/02    93 03/13/02   1/14  Irritation Site Of Application

  REMOVED  **  CID    99 **   REASON - TSAC
                                 93 03/13/02         Irritation Site Of Application

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 9
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 22                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 87.5    MG/KG      PROCEDURE SET:      4
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 10
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 11                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 175     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

101         101   93 03/13/02    93 03/13/02   1/14  Irritation Site Of Application

  REMOVED  **  CID   101 **   REASON - TSAC
                                 93 03/13/02         Irritation Site Of Application

102         102   85 03/05/02    85 03/05/02   1/14  Ulcer Site Of Application
                  85 03/05/02    85 03/05/02   1/14  Thickened Site Of Application
                  78 02/26/02    93 03/13/02   2/14  Irritation Site Of Application

  REMOVED  **  CID   102 **   REASON - TSAC
                                 93 03/13/02         Irritation Site Of Application

103         103   78 02/26/02    93 03/13/02   3/14  Irritation Site Of Application
                  85 03/05/02    93 03/13/02   2/14  Thickened Site Of Application

  REMOVED  **  CID   103 **   REASON - TSAC
                                 93 03/13/02         Thickened Site Of Application
                                 93 03/13/02         Irritation Site Of Application

104         104   36 01/15/02    36 01/15/02   1/14  Irritation Site Of Application
                  85 03/05/02    93 03/13/02   2/14  Thickened Site Of Application

  REMOVED  **  CID   104 **   REASON - TSAC
                                 93 03/13/02         Thickened Site Of Application

105         105   44 01/23/02    78 02/26/02   2/14  Irritation Site Of Application
                  85 03/05/02    93 03/13/02   2/14  Thickened Site Of Application
                  93 03/13/02    93 03/13/02   1/14  Ulcer Site Of Application

  REMOVED  **  CID   105 **   REASON - TSAC
                                 93 03/13/02         Ulcer Site Of Application
                                 93 03/13/02         Thickened Site Of Application

106         106   85 03/05/02    93 03/13/02   2/14  Thickened Site Of Application
                  78 02/26/02    93 03/13/02   2/14  Irritation Site Of Application

  REMOVED  **  CID   106 **   REASON - TSAC
                                 93 03/13/02         Thickened Site Of Application
                                 93 03/13/02         Irritation Site Of Application

107         107   72 02/20/02    78 02/26/02   2/14  Ulcer Site Of Application
                  78 02/26/02    78 02/26/02   1/14  Irritation Site Of Application

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 11
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 11                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 175     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
107         107   85 03/05/02    85 03/05/02   1/14  Thickened Site Of Application

  REMOVED  **  CID   107 **   REASON - TSAC
                                 93 03/13/02         Unremarkable

108         108   93 03/13/02    93 03/13/02   1/14  Ulcer Site Of Application
                  44 01/23/02    78 02/26/02   2/14  Irritation Site Of Application
                  85 03/05/02    93 03/13/02   2/14  Thickened Site Of Application

  REMOVED  **  CID   108 **   REASON - TSAC
                                 93 03/13/02         Ulcer Site Of Application
                                 93 03/13/02         Thickened Site Of Application

109         109   93 03/13/02    93 03/13/02   1/14  Thickened Site Of Application
                  85 03/05/02    85 03/05/02   1/14  Irritation Site Of Application
                  72 02/20/02    78 02/26/02   2/14  Ulcer Site Of Application

  REMOVED  **  CID   109 **   REASON - TSAC
                                 93 03/13/02         Thickened Site Of Application

110         110   44 01/23/02    44 01/23/02   1/14  Irritation Site Of Application

  REMOVED  **  CID   110 **   REASON - TSAC
                                 93 03/13/02         Unremarkable

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 12
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 23                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 175     MG/KG      PROCEDURE SET:      4
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 13
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 12                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 350     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

111         111   78 02/26/02    78 02/26/02   1/14  Ulcer Site Of Application
                   8 12/18/01    85 03/05/02   2/14  Thickened Site Of Application
                  29 01/08/02    93 03/13/02  10/14  Irritation Site Of Application

  REMOVED  **  CID   111 **   REASON - TSAC
                                 93 03/13/02         Irritation Site Of Application

112         112    8 12/18/01    93 03/13/02   3/14  Thickened Site Of Application
                  29 01/08/02    93 03/13/02  10/14  Irritation Site Of Application

  REMOVED  **  CID   112 **   REASON - TSAC
                                 93 03/13/02         Thickened Site Of Application
                                 93 03/13/02         Irritation Site Of Application

113         113   29 01/08/02    93 03/13/02   8/14  Irritation Site Of Application
                  72 02/20/02    78 02/26/02   2/14  Ulcer Site Of Application
                   8 12/18/01    93 03/13/02   3/14  Thickened Site Of Application

  REMOVED  **  CID   113 **   REASON - TSAC
                                 93 03/13/02         Thickened Site Of Application
                                 93 03/13/02         Irritation Site Of Application

114         114    8 12/18/01    16 12/26/01   2/14  Thickened Site Of Application
                  23 01/02/02    93 03/13/02  10/14  Irritation Site Of Application

  REMOVED  **  CID   114 **   REASON - TSAC
                                 93 03/13/02         Irritation Site Of Application

115         115    8 12/18/01    93 03/13/02   4/14  Thickened Site Of Application
                  29 01/08/02    93 03/13/02  10/14  Irritation Site Of Application

  REMOVED  **  CID   115 **   REASON - TSAC
                                 93 03/13/02         Thickened Site Of Application
                                 93 03/13/02         Irritation Site Of Application

116         116    8 12/18/01    85 03/05/02   3/14  Thickened Site Of Application
                  72 02/20/02    78 02/26/02   2/14  Ulcer Site Of Application
                  36 01/15/02    93 03/13/02   9/14  Irritation Site Of Application

  REMOVED  **  CID   116 **   REASON - TSAC
                                 93 03/13/02         Irritation Site Of Application

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 14
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 12                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 350     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

117         117    8 12/18/01    93 03/13/02   3/14  Thickened Site Of Application
                  29 01/08/02    93 03/13/02  10/14  Irritation Site Of Application

  REMOVED  **  CID   117 **   REASON - TSAC
                                 93 03/13/02         Thickened Site Of Application
                                 93 03/13/02         Irritation Site Of Application

118         118    8 12/18/01    93 03/13/02   3/14  Thickened Site Of Application
                  78 02/26/02    93 03/13/02   3/14  Ulcer Site Of Application
                  29 01/08/02    93 03/13/02  10/14  Irritation Site Of Application

  REMOVED  **  CID   118 **   REASON - TSAC
                                 93 03/13/02         Ulcer Site Of Application
                                 93 03/13/02         Thickened Site Of Application
                                 93 03/13/02         Irritation Site Of Application

119         119    8 12/18/01    16 12/26/01   2/14  Thickened Site Of Application
                  29 01/08/02    93 03/13/02   9/14  Irritation Site Of Application

  REMOVED  **  CID   119 **   REASON - TSAC
                                 93 03/13/02         Irritation Site Of Application

120         120   29 01/08/02    93 03/13/02  10/14  Irritation Site Of Application
                   8 12/18/01    16 12/26/01   2/14  Thickened Site Of Application

  REMOVED  **  CID   120 **   REASON - TSAC
                                 93 03/13/02         Irritation Site Of Application

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 15
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 24                     ROOM/AREA:     39         FIRST DOSE: 12/11/01
            SEX: FEMALE                               TRT: 350     MG/KG      PROCEDURE SET:      4
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 16
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 1                      ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: VEHICLE CONTROL    PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 17
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 13                     ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: CONTROL SPECIAL    PROCEDURE SET:      3
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 18
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 2                      ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 22.0    MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 19
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 14                     ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 22.0    MG/KG      PROCEDURE SET:      3
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 20
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 3                      ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 44.0    MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

24           24   57 02/04/02    57 02/04/02   1/14  Irritation Site Of Application

  REMOVED  **  CID    24 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

26           26   57 02/04/02    57 02/04/02   1/14  Irritation Site Of Application

  REMOVED  **  CID    26 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

27           27   72 02/19/02    72 02/19/02   1/14  Irritation Site Of Application

  REMOVED  **  CID    27 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

28           28   78 02/25/02    85 03/04/02   2/14  Irritation Site Of Application

  REMOVED  **  CID    28 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

30           30   85 03/04/02    85 03/04/02   1/14  Irritation Site Of Application

  REMOVED  **  CID    30 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 21
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 15                     ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 44.0    MG/KG      PROCEDURE SET:      3
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 22
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 87.5    MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

31           31   85 03/04/02    85 03/04/02   1/14  Irritation Site Of Application

  REMOVED  **  CID    31 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

34           34   72 02/19/02    78 02/25/02   2/14  Irritation Site Of Application

  REMOVED  **  CID    34 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

35           35   22 12/31/01    78 02/25/02   2/14  Irritation Site Of Application

  REMOVED  **  CID    35 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

36           36   22 12/31/01    85 03/04/02   4/14  Irritation Site Of Application

  REMOVED  **  CID    36 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

37           37   22 12/31/01    29 01/07/02   2/14  Irritation Site Of Application

  REMOVED  **  CID    37 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

38           38   22 12/31/01    78 02/25/02   4/14  Irritation Site Of Application

  REMOVED  **  CID    38 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

39           39   22 12/31/01    85 03/04/02   3/14  Irritation Site Of Application

  REMOVED  **  CID    39 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

40           40   22 12/31/01    29 01/07/02   2/14  Irritation Site Of Application

  REMOVED  **  CID    40 **   REASON - TSAC
                                 93 03/12/02         Unremarkable

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 23
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 16                     ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 87.5    MG/KG      PROCEDURE SET:      3
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 24
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 175     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

41           41   22 12/31/01    93 03/12/02  10/14  Irritation Site Of Application
                  36 01/14/02    36 01/14/02   1/14  Thickened Site Of Application

  REMOVED  **  CID    41 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

42           42   22 12/31/01    93 03/12/02   8/14  Irritation Site Of Application

  REMOVED  **  CID    42 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

43           43   15 12/24/01    15 12/24/01   1/14  Thickened Site Of Application
                  22 12/31/01    93 03/12/02   9/14  Irritation Site Of Application

  REMOVED  **  CID    43 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

44           44   22 12/31/01    93 03/12/02   9/14  Irritation Site Of Application
                  22 12/31/01    93 03/12/02   3/14  Ulcer Site Of Application
                  15 12/24/01    15 12/24/01   1/14  Thickened Site Of Application

  REMOVED  **  CID    44 **   REASON - TSAC
                                 93 03/12/02         Ulcer Site Of Application
                                 93 03/12/02         Irritation Site Of Application

45           45   15 12/24/01    93 03/12/02  10/14  Irritation Site Of Application
                  22 12/31/01    22 12/31/01   1/14  Thickened Site Of Application

  REMOVED  **  CID    45 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

46           46   78 02/25/02    78 02/25/02   1/14  Thickened Site Of Application
                  22 12/31/01    93 03/12/02   9/14  Irritation Site Of Application

  REMOVED  **  CID    46 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

47           47   22 12/31/01    93 03/12/02   8/14  Irritation Site Of Application

  REMOVED  **  CID    47 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 25
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 175     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

48           48   22 12/31/01    93 03/12/02   9/14  Irritation Site Of Application
                  85 03/04/02    93 03/12/02   2/14  Ulcer Site Of Application

  REMOVED  **  CID    48 **   REASON - TSAC
                                 93 03/12/02         Ulcer Site Of Application
                                 93 03/12/02         Irritation Site Of Application

49           49   22 12/31/01    93 03/12/02   8/14  Irritation Site Of Application

  REMOVED  **  CID    49 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

50           50   15 12/24/01    78 02/25/02   2/14  Thickened Site Of Application
                  22 12/31/01    93 03/12/02   8/14  Irritation Site Of Application
                  72 02/19/02    85 03/04/02   3/14  Ulcer Site Of Application

  REMOVED  **  CID    50 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 26
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 17                     ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 175     MG/KG      PROCEDURE SET:      3
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 27
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 350     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

51           51    8 12/17/01    15 12/24/01   2/14  Thickened Site Of Application
                  22 12/31/01    93 03/12/02  11/14  Irritation Site Of Application

  REMOVED  **  CID    51 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

52           52   22 12/31/01    93 03/12/02  10/14  Irritation Site Of Application

  REMOVED  **  CID    52 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

53           53    8 12/17/01    93 03/12/02   4/14  Thickened Site Of Application
                  72 02/19/02    72 02/19/02   1/14  Ulcer Site Of Application
                  22 12/31/01    93 03/12/02  11/14  Irritation Site Of Application

  REMOVED  **  CID    53 **   REASON - TSAC
                                 93 03/12/02         Thickened Site Of Application
                                 93 03/12/02         Irritation Site Of Application

54           54   22 12/31/01    93 03/12/02   8/14  Irritation Site Of Application
                   8 12/17/01     8 12/17/01   1/14  Thickened Site Of Application

  REMOVED  **  CID    54 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

55           55   22 12/31/01    93 03/12/02  11/14  Irritation Site Of Application
                   8 12/17/01     8 12/17/01   1/14  Thickened Site Of Application

  REMOVED  **  CID    55 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

56           56    8 12/17/01    22 12/31/01   3/14  Thickened Site Of Application
                  22 12/31/01    93 03/12/02  11/14  Irritation Site Of Application

  REMOVED  **  CID    56 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

57           57   22 12/31/01    93 03/12/02  10/14  Irritation Site Of Application
                   8 12/17/01     8 12/17/01   1/14  Thickened Site Of Application

  REMOVED  **  CID    57 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 28
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 350     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

58           58    8 12/17/01     8 12/17/01   1/14  Thickened Site Of Application
                  22 12/31/01    93 03/12/02  11/14  Irritation Site Of Application

  REMOVED  **  CID    58 **   REASON - TSAC
                                 93 03/12/02         Irritation Site Of Application

59           59   15 12/24/01    93 03/12/02  12/14  Irritation Site Of Application
                   8 12/17/01    93 03/12/02   2/14  Thickened Site Of Application

  REMOVED  **  CID    59 **   REASON - TSAC
                                 93 03/12/02         Thickened Site Of Application
                                 93 03/12/02         Irritation Site Of Application

60           60   22 12/31/01    93 03/12/02  10/14  Irritation Site Of Application
                  72 02/19/02    78 02/25/02   2/14  Ulcer Site Of Application
                   8 12/17/01    93 03/12/02   5/14  Thickened Site Of Application

  REMOVED  **  CID    60 **   REASON - TSAC
                                 93 03/12/02         Thickened Site Of Application
                                 93 03/12/02         Irritation Site Of Application

NTP  EXP/TEST: 95003-03                            METHYL TRANS-STYRYL KETONE                                     PAGE: 29
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/22/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 08:57:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 18                     ROOM/AREA:     39         FIRST DOSE: 12/10/01
            SEX: MALE                                 TRT: 350     MG/KG      PROCEDURE SET:      3
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------