VACCINE
MANAGEMENT
Recommendations for
Storage and Handling of
Selected Biologicals
November 2007
Department of Health and Human Services
Centers for Disease Control and Prevention
Contents
DT, Td . 3
DTaP, DTaP/Hib, DTaP/HepB/IPV,Tdap 4
Hepatitis Vaccines: Hepatitis A, Hepatitis B, Hepatitis A/B, Hepatitis B/Hib 5
Hib 6
HPV 7
IPV 8
TIV 9
LAIV 10
MMR, MR, Measles Virus Vaccine, Mumps Virus Vaccine, Rubella Virus Vaccine 11
MMRV 12
MCV 13
MPSV 14
PCV 15
PPV 16
Rotavirus Vaccine 17
Varicella (Chickenpox) Vaccine 18
Zoster (Shingles) Vaccine 19
Manufacturer Quality Control Office Telephone Numbers 20
DT: Diphtheria, Tetanus ToxoidsPediatric
Td: Tetanus, Diphtheria ToxoidsAdult
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial or manufacturer-filled syringe.
Instructions for Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial or manufacturer-filled syringe well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Opening
Single-Dose Vials: The vaccine should be administered shortly after withdrawal from the vial.
Multidose Vials: Withdraw single dose of vaccine into separate sterile needle and syringe for each immunization. The vaccine should be administered shortly after withdrawal from the vial. Unused portions of multidose vials may be refrigerated at
35  46F (2  8C) and used until expired, if not contaminated or unless otherwise stated in the manufacturers product information.
Manufacturer-Filled Syringes: The vaccine should be administered shortly after the needle is attached to the syringe.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
DTaP: Diphtheria Toxoid, Tetanus Toxoid,
Acellular Pertussis VaccinePediatric
DTaP/Hib: Diphtheria Toxoid, Tetanus Toxoid,
Acellular Pertussis Vaccine Combined with Haemophilus influenzae type b Conjugate Vaccine*Pediatric
DTaP/HepB/IPV: Diphtheria Toxoid, Tetanus Toxoid,
Acellular Pertussis Vaccine, Hepatitis B Vaccine,
Inactivated Polio VaccinePediatric
Tdap: Tetanus Toxoid, Diphtheria Toxoid,
Acellular Pertussis VaccineAdult
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial, or manufacturer-filled syringe.
Instructions for Reconstitution* or Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial or manufacturer-filled syringe well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Reconstitution* or Opening
Single-Dose Vials: The vaccine should be administered shortly after withdrawal from the vial.
Manufacturer-Filled Syringes: The vaccine should be administered shortly after the needle is attached to the syringe.
Special Instructions
Rotate stock so that the earliest dated
material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
* DTaP/Hib (TriHIBit) is ActHIB (sanofi pasteur) reconstituted with Tripedia (sanofi pasteur). Once reconstituted, this combination vaccine must be used within 30 minutes or discarded. The only DTaP vaccine that can be used to reconstitute ActHIB is Tripedia. No other brand of DTaP is approved for this use.
Hepatitis Vaccines:
Hepatitis A, Hepatitis B, Hepatitis A/B,
Hepatitis B/Haemophilus influenzae type b
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial or manufacturer-filled syringe.
Instructions for Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial or manufacturer-filled syringe well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Opening
Single-Dose Vials: The vaccine should be administered shortly after withdrawal from the vial.
Manufacturer-Filled Syringes: The vaccine should be administered shortly after the needle is attached to the syringe.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
Hib: Haemophilus influenzae type b
Conjugate Vaccine
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Vaccine: Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures.
Diluent: May be refrigerated or stored at room temperature (68  77F
[20  25C]). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial.
Instructions for Reconstitution* or Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Reconstitution* or Opening
Single-Dose Vials: The vaccine should be administered shortly after withdrawal from the vial.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
*
ActHIB (sanofi pasteur) reconstituted with 0.4% sodium chloride diluent should be used within 24 hours after reconstitution. If sanofi pasteur DTaP-Tripedia is used to reconstitute ActHIB, the TriHibit vaccine must be used within 30 minutes of reconstitution. Only sanofi pasteur DTaP-Tripedia or the diluent shipped with the product may be used to reconstitute the sanofi pasteur ActHIB product. No other brand of DTaP is licensed for use in reconstitution of ActHIB.
HPV: Human Papillomavirus Vaccine
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures. Protect from light at all times.
Shelf Life
Check expiration date on vial or manufacturer-filled syringe.
Instructions for Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial or manufacturer-filled syringe well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Opening
Single-Dose Vials: The vaccine should be administered shortly after withdrawal from the vial.
Manufacturer-Filled Syringes: The vaccine should be administered shortly after the needle is attached to the syringe.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
IPV: Inactivated Polio Vaccine
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial or manufacturer-filled syringe.
Instructions for Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial or manufacturer-filled syringe well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Opening
Multidose Vials: Withdraw single dose of vaccine into separate sterile needle and syringe for each immunization. The vaccine should be administered shortly after withdrawal from the vial. Unused portions of multidose vials may be refrigerated at
35  46F (2  8C) and used until expired, if not contaminated or unless otherwise stated in the manufacturers product information.
Manufacturer-Filled Syringes: The vaccine should be administered shortly after the needle is attached to the syringe.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
TIV: Trivalent Inactivated Influenza Vaccine
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures. Protect Fluarix and FluLaval from light at all times by storing in original package.
Shelf Life
Formulated for use during current influenza season. Check expiration date on vial or manufacturer-filled syringe.
Instructions for Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial or manufacturer-filled syringe well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Opening
Single-Dose Vials: The vaccine should be administered shortly after withdrawal from the vial.
Multidose Vials: Withdraw single dose of vaccine into separate sterile needle and syringe for each immunization. The vaccine should be administered shortly after withdrawal from the vial. Unused portions of multidose vials may be refrigerated at
35  46F (2  8C) and used until expired, if not contaminated or unless otherwise stated in the manufacturers product information.
Manufacturer-Filled Syringes: The vaccine should be administered shortly after the needle is attached to the syringe.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
LAIV: Live Attenuated Influenza Vaccine
Shipping Requirements
Initially shipped to authorized distributors in the frozen state 5F (-15C). Shipped from the distributor to healthcare facilities in the refrigerated state at 35  46F
(2  8C).
Condition upon Arrival
Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures. (If LAIV is inadvertently frozen, the vaccine should be moved immediately to the refrigerator and may be used until the expiration date printed on the package.)
Shelf Life
Formulated for use during current influenza season. Check expiration date on package.
Instructions for Use
LAIV is a colorless to pale yellow liquid and is clear to slightly cloudy; some particulates may be present but do not affect the use of the product. After removal of the sprayer from the refrigerator, remove the rubber tip protector. Follow manufacturers instructions to deliver  dose into one nostril. Then remove the dose-divider clip and deliver the remainder of the dose into the other nostril.
Shelf Life after Opening
Single-Dose Sprayer: The vaccine should be administered shortly after removal from the refrigerator.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
MMR: Measles/Mumps/Rubella Vaccine,
MR: Measles/Rubella Vaccine,
Measles Virus Vaccine, Mumps Virus Vaccine, Rubella Virus Vaccine
Shipping Requirements
Vaccine: Should be shipped in insulated container. Must be shipped with refrigerant. Maintain temperature at 50F (10C) or less. If shipped with dry ice, diluent must be shipped separately.
Diluent: May be shipped with vaccine, but do not place in container with dry ice.
Condition upon Arrival
Maintain at 50F (10 C) or less. Do not use warm vaccine. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Vaccine: Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Protect from light at all times, since such exposure may inactivate the vaccine viruses.
Diluent: May be refrigerated or stored at room temperature (68  77F
[20  25C]). Do not freeze or expose to freezing temperatures.
Note: MMR vaccine may be stored in the refrigerator or freezer.
Shelf Life
Check expiration date on vial.
Instructions for Reconstitution and Use
Reconstitute just before use according to the manufacturers instructions. Use only the diluent supplied to reconstitute the vaccine.
Shelf Life after Reconstitution, Thawing or Opening
Single-Dose Vials: After reconstitution, use immediately or store at 35  46F
(2  8C) and protect from light. Discard if not used within 8 hours of reconstitution.
Multidose vials: Withdraw single dose of reconstituted vaccine into separate sterile needle and syringe for each immunization. The vaccine dose should be administered shortly after withdrawal from vial. Unused portions of multidose vials may be refrigerated at 35  46F (2  8C), but must be discarded if not used within 8 hours after reconstitution.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
MMRV: Measles/Mumps/Rubella/Varicella Vaccine
Shipping Requirements
Vaccine: Should be shipped in insulated container. Must be shipped with dry ice only, at 5F (-15C) or colder. Should be delivered within 2 days.
Diluent: May be shipped with vaccine, but do not place in container with dry ice.
Condition upon Arrival
Should be frozen. Vaccine should remain at 5F (-15C) or colder until arrival at the healthcare facility. Dry ice should still be present in the shipping container when vaccine is delivered.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Vaccine: Freeze immediately upon arrival. Maintain vaccine in a continuously frozen state at 5F (-15C) or colder. No freeze/thaw cycles are allowed with this vaccine. Vaccine should only be stored in freezers or refrigerator/freezers with separate external doors and compartments. Acceptable storage may be achieved in standard household freezers purchased in the last
10 years, and standard household refrigerator/freezers with a separate, sealed freezer compartment. "Dormitory-style units" are not appropriate for the storage of MMRV vaccine. Do not store lyophilized vaccine in the refrigerator. If lyophilized vaccine is inadvertently stored in the refrigerator, it should be used within
72 hours. Lyophilized vaccine stored at
35  46F (2  8C) which is not used within 72 hours should be discarded.
Protect the vaccine from light at all times since such exposure may inactivate the vaccine viruses.
In order to maintain temperatures of
5F (-15C) or colder, it will be necessary in most refrigerator/freezer models to adjust the temperature dial down to the coldest setting. This may result in the refrigerator compartment temperature being lowered as well. Careful monitoring of the refrigerator temperature will be necessary to avoid freezing killed or inactivated vaccines.
Diluent: May be refrigerated or stored at room temperature (68  77F
[20  25C]). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial.
Instructions for Reconstitution and Use
Reconstitute just before use according to the manufacturers instructions. Use only the diluent supplied to reconstitute the vaccine.
Shelf Life after Reconstitution, Thawing or Opening
Single-Dose Vials: Discard reconstituted vaccine if it is not used within
30 minutes of reconstitution. Do not freeze reconstituted vaccine.
Special Instructions
Rotate stock so that the earliest dated material is used first.
If this vaccine is stored at a temperature warmer than 5F (-15C), it will result in a loss of potency and a reduced shelf life. If a power outage or some other situation occurs that results in the vaccine storage temperature rising above the recommended temperature, the healthcare provider should contact Merck, the vaccine manufacturer, at 1-800-MERCK-90 for an evaluation of the product potency before using the vaccine.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
MCV: Meningococcal Conjugate Vaccine
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures. Protect from light at all times.
Shelf Life
Check expiration date on vial or manufacturer-filled syringe.
Instructions for Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial or manufacturer-filled syringe well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Opening
Single-Dose Vials: The vaccine should be administered shortly after withdrawal from the vial.
Manufacturer-Filled Syringes: The vaccine should be administered shortly after the needle is attached to the syringe.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
MPSV: Meningococcal Polysaccharide Vaccine
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Vaccine: Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures.
Diluent: May be refrigerated or stored at room temperature (68  77F
[20  25C]). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial.
Instructions for Reconstitution and Use
Reconstitute just before using according to the manufacturers instructions. Use only the diluent supplied to reconstitute the vaccine.
Shelf Life after Reconstitution or Opening
Single-Dose Vials: Use within 30 minutes of reconstitution.
Multidose Vials: Unused portions of multidose vials may be refrigerated at
35  46F (2  8C) and used up to
35 days after reconstitution.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
PCV: Pneumococcal Conjugate Vaccine
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial or manufacturer-filled syringe.
Instructions for Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial or manufacturer-filled syringe well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Opening
Single-Dose Vials: The vaccine should be administered shortly after withdrawal from the vial.
Manufacturer-Filled Syringes: The vaccine should be administered shortly after the needle is attached to the syringe.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
PPV: Pneumococcal Polysaccharide Vaccine
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial.
Instructions for Use
Inspect visually for extraneous particulate matter and/or discoloration. If these conditions exist, the vaccine should not be used. Shake vial or manufacturer-filled syringe well before use. Discard vaccine if it cannot be resuspended with thorough agitation.
Shelf Life after Opening
Single-Dose Vials: The vaccine should be administered shortly after withdrawal from the vial.
Multidose Vials: Withdraw single dose of vaccine into separate sterile needle and syringe for each immunization. The vaccine should be administered shortly after withdrawal from the vial. Unused portions of multidose vials may be refrigerated at
35  46F (2  8C) and used until expired, if not contaminated or unless otherwise stated in the manufacturers product information.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
Rotavirus Vaccine
Shipping Requirements
Should be shipped in insulated container. Maintain temperature at 35  46F
(2  8C). Do not freeze or expose to freezing temperatures.
Condition upon Arrival
Should not have been frozen or exposed to freezing temperatures. Refrigerate upon arrival.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Refrigerate immediately upon arrival. Store at 35  46F (2  8C). Do not freeze or expose to freezing temperatures. Protect from light at all times, since such exposure may inactivate the vaccine viruses.
Shelf Life
Check expiration date on package.
Instructions for Use
Each dose is supplied in a container consisting of a squeezable plastic, latex-free dosing tube with a twist-off cap, allowing for direct oral administration. The dosing tube is contained in a pouch. Remove the dosing tube from the pouch, screw the cap clockwise to puncture the tube, and screw the cap off counter-clockwise so that the liquid can be squeezed from the tube during oral administration of the vaccine.
Shelf Life after Opening
Pouched Single-Dose Tubes: The vaccine should be administered shortly after withdrawal from the refrigerator. The dosing tube should not be returned to the refrigerator once the screw cap has
been removed.
Special Instructions
Rotate stock so that the earliest dated material is used first.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
Varicella (Chickenpox) Vaccine
Shipping Requirements
Vaccine: Should be shipped in insulated container. Must be shipped with dry ice only, at 5F (-15C) or colder. Should be delivered within 2 days.
Diluent: May be shipped with vaccine, but do not place in container with dry ice.
Condition upon Arrival
Should be frozen. Vaccine should remain at 5F (-15C) or colder until arrival at the healthcare facility. Dry ice should still be present in the shipping container when vaccine is delivered.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Vaccine: Freeze immediately upon arrival. Maintain vaccine in a continuously frozen state at 5F (-15C) or colder. No freeze/thaw cycles are allowed with this vaccine. Vaccine should only be stored in freezers or refrigerator/freezers with separate external doors and compartments. Acceptable storage may be achieved in standard household freezers purchased in the last
10 years, and standard household refrigerator/freezers with a separate, sealed freezer compartment. "Dormitory-style units" are not appropriate for the storage of varicella vaccine. Do not store lyophilized vaccine in the refrigerator. If lyophilized vaccine is inadvertently stored in the refrigerator, it should be used within
72 hours. Lyophilized vaccine stored at 35  46F (2  8C) which is not used within 72 hours, should be discarded.
Protect the vaccine from light at all times since such exposure may inactivate the vaccine virus.
In order to maintain temperatures of
5F (-15C) or colder, it will be necessary in most refrigerator/freezer models to turn the temperature dial down to the coldest setting. This may result in the refrigerator compartment temperature being lowered as well. Careful monitoring of the refrigerator temperature will be necessary to avoid freezing killed or inactivated vaccines.
Diluent: May be refrigerated or stored at room temperature (68  77F
[20  25C]). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial.
Instructions for Reconstitution and Use
Reconstitute just before use according to the manufacturers instructions. Use only the diluent supplied to reconstitute the vaccine.
Shelf Life after Reconstitution, Thawing or Opening
Single-Dose Vials: Discard reconstituted vaccine if it is not used within 30 minutes of reconstitution. Do not freeze reconstituted vaccine.
Special Instructions
Rotate stock so that the earliest dated material is used first.
If this vaccine is stored at a temperature warmer than 5F (-15C), it will result in a loss of potency and a reduced shelf life. If a power outage or some other situation occurs that results in the vaccine storage temperature rising above the recommended temperature, the healthcare provider should contact Merck, the vaccine manufacturer, at 1-800-9-VARIVAX for an evaluation of the product potency before using the vaccine.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
Zoster (Shingles) Vaccine
Shipping Requirements
Vaccine: Should be shipped in insulated container. Must be shipped with dry ice only, at 5F (-15C) or colder. Should be delivered within 2 days.
Diluent: May be shipped with vaccine, but do not place in container with dry ice.
Condition upon Arrival
Should be frozen. Vaccine should remain at 5F (-15C) or colder until arrival at the healthcare facility. Dry ice should still be present in the shipping container when vaccine is delivered.
If you have questions about the condition of the material at the time of delivery, you should 1) immediately place material in recommended storage; and 2) then follow your state health department immunization program policy and contact either the Manufacturers Quality Control office or the immunization program for guidance.
Storage Requirements
Vaccine: Freeze immediately upon arrival. Maintain vaccine in a continuously frozen state at 5F (-15C) or colder. No freeze/thaw cycles are allowed with this vaccine. Vaccine should only be stored in freezers or refrigerator/freezers with separate external doors and compartments. Acceptable storage may be achieved in standard household freezers purchased in the last 10 years, and standard household refrigerator/freezers with a separate, sealed freezer compartment. "Dormitory-style units" are not appropriate for the storage of zoster vaccine. Do not store lyophilized vaccine in the refrigerator. Protect the vaccine from light at all times since such exposure may inactivate the vaccine virus.
In order to maintain temperatures of
5F (-15C) or colder, it will be necessary in most refrigerator/freezer models to turn the temperature dial down to the coldest setting. This may result in the refrigerator compartment temperature being lowered as well. Careful monitoring of the refrigerator temperature will be necessary to avoid freezing killed or inactivated vaccines.
Diluent: May be refrigerated or stored at room temperature (68  77F [20  25C]). Do not freeze or expose to freezing temperatures.
Shelf Life
Check expiration date on vial.
Instructions for Reconstitution and Use
Reconstitute just before use according to the manufacturers instructions. Use only the diluent supplied to reconstitute the vaccine.
Shelf Life after Reconstitution, Thawing or Opening
Single-Dose Vials: Discard reconstituted vaccine if it is not used within 30 minutes of reconstitution. Do not freeze reconstituted vaccine.
Special Instructions
Rotate stock so that the earliest dated material is used first.
If this vaccine is stored at a temperature warmer than 5F (-15C), it will result in a loss of potency and a reduced shelf life. If a power outage or some other situation occurs that results in the vaccine storage temperature rising above the recommended temperature, the healthcare provider should contact Merck, the vaccine manufacturer, at
1-800-MERCK-90 for an evaluation of the product potency before using the vaccine.
Note: All vaccine materials should be disposed of using medical waste disposal procedures. Contact the state health department for details.
Manufacturer Quality Control Office
Telephone Numbers
Manufacturer/Distributor
sanofi pasteur
www.sanofipasteur.us
Talecris Biotherapeutics
www.talecrisusa.com/
Centers for Disease Control and Prevention
Drug Service
www.cdc.gov/ncidod/srp/drugs/drug-service.html
Novartis
www.novartis-vaccines.com/products/index.shtml
GlaxoSmithKline
www.gsk.com/
Massachusetts Biological Labs
MedImmune, Inc.
www.medimmune.com
Merck
www.merckvaccines.com
Nabi Biopharmaceuticals
www.nabi.com
Wyeth
www.wyeth.com
Telephone
Number
800-822-2463
800-520-2807
404-639-3670
800-244-7668
866-475-8222
(customer support)
888-825-5249
(customer support)
617-474-3000
617-983-6400
877-358-6478
800-637-2590
800-635-1766
800-999-9384
Products
DTaP, DTaP-Hib, DT, Td, Tdap, TT, Hib, Influenza (TIV), IPV, MCV4, MPSV4
HBIG, IGIM, RIG, TIG
Distributor for Diphtheria antitoxin
Influenza (TIV)
DTaP, DTaP-HepB-IPV,Tdap, HepA, HepB, HepA-HepB,
Influenza (TIV)
Td, IGIM,
TT
Influenza (LAIV)
Hib, Hib-HepB, HepA, HepB, HPV, Measles, Mumps, Rubella, MMR, MMRV, PPV23, Rotavirus, Varicella, Zoster
HBIG
Hib, PCV7
http://www.cdc.gov/vaccines/pubs/downloads/bk-vac-mgt.txt