NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 1
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                                                                             TIME: 11:16:00

                                                         EIS REPORT 27
                                                      lifetime/draft/mice

       FACILITY:  TSI Mason Research

       NTP C#:  C62419

       CONTRACT NUMBER:  NO1ES55111

       CAS NUMBER:  MOUSEAGE

       ANIMAL SUPPLIER:  NOT SPECIFIED

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 2
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

301         301  966 05/17/88   966 05/17/88   1/46  Tachypnea

  REMOVED  **  CID  3011 **   REASON - Moribund
                                969 05/20/88         Abnormal Posture
                                969 05/20/88         Tachypnea
                                969 05/20/88         Hypoactivity

302         302  140 02/11/86   644 06/30/87  19/41  Alopecia Entire Animal

  REMOVED  **  CID  3021 **   REASON - Moribund
                                841 01/13/88         Emaciated
                                841 01/13/88         Abnormal Posture
                                841 01/13/88         Tachypnea
                                841 01/13/88         Hypoactivity

303         303 1022 07/12/88  1022 07/12/88   1/50  Tachypnea
                1022 07/12/88  1022 07/12/88   1/50  Ruffled Fur
                1008 06/28/88  1022 07/12/88   2/50  Tissue Mass Right Rear Leg 16-20 Mm
                 994 06/14/88   994 06/14/88   1/50  Tissue Mass Right Rear Leg  3- 5 Mm
                 897 03/09/88   980 05/31/88   5/50  Tissue Mass Right Rear Leg  6-10 Mm
                 868 02/09/88  1022 07/12/88   9/50  Alopecia Body Ventral
                 700 08/25/87   835 01/07/88   6/50  Alopecia Neck

  REMOVED  **  CID  3031 **   REASON - Moribund
                               1023 07/13/88         Tissue Mass Right Rear Leg 26 or Gr
                               1023 07/13/88         Ruffled Fur
                               1023 07/13/88         Tachypnea
                               1023 07/13/88         Hypoactivity

305         305  897 03/09/88   897 03/09/88   1/43  Tissue Mass Body Dorsal 11-15 Mm
                 897 03/09/88   897 03/09/88   1/43  Ruffled Fur
                 897 03/09/88   897 03/09/88   1/43  Emaciated

  REMOVED  **  CID  3051 **   REASON - Moribund
                                904 03/16/88         Tremors
                                904 03/16/88         Tissue Mass Body Ventral 26 or Gr
                                904 03/16/88         Abnormal Posture
                                904 03/16/88         Tachypnea
                                904 03/16/88         Hypoactivity

306         306  567 04/14/87   595 05/12/87   2/32  Tissue Mass Body (Trunk)  3- 5 Mm

  REMOVED  **  CID  3061 **   REASON - Dead
                                601 05/18/87         Tissue Mass Body Ventral 26 or Gr

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 3
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

307         307  672 07/28/87   728 09/22/87   3/38  Sore Nose  0- 2 Mm
                 756 10/20/87   756 10/20/87   1/38  Tissue Mass Nose  0- 2 Mm

  REMOVED  **  CID  3071 **   REASON - Moribund
                                779 11/12/87         Dyspnea
                                779 11/12/87         Emaciated
                                779 11/12/87         Abnormal Posture

308         308  534 03/12/87   868 02/09/88  12/42  Alopecia Body Ventral
                 868 02/09/88   868 02/09/88   1/42  Tachypnea
                 785 11/18/87   868 02/09/88   4/42  Tissue Mass Hip  3- 5 Mm

  REMOVED  **  CID  3081 **   REASON - Moribund
                                876 02/17/88         Tissue Mass Hip 26 or Gr
                                876 02/17/88         Abnormal Posture
                                876 02/17/88         Tachypnea
                                876 02/17/88         Hypoactivity

309         309  450 12/18/86   672 07/28/87   4/35  Alopecia Body Ventral
                 506 02/12/87   616 06/02/87   5/35  Alopecia Entire Animal

  REMOVED  **  CID  3091 **   REASON - Moribund
                                698 08/23/87         Emaciated
                                698 08/23/87         Abnormal Posture
                                698 08/23/87         Ruffled Fur

311         311  805 12/08/87   805 12/08/87   1/40  Tissue Mass Hip  6-10 Mm
                 196 04/08/86   805 12/08/87  20/40  Alopecia Body Ventral
                 567 04/14/87   616 06/02/87   3/40  Alopecia Entire Animal

  REMOVED  **  CID  3111 **   REASON - Moribund
                                816 12/19/87         Tissue Mass Body Ventral 21-25 Mm
                                816 12/19/87         Limb Paralysis Right Rear Leg
                                816 12/19/87         Limb Paralysis Left Rear Leg

312         312  616 06/02/87   616 06/02/87   1/40  Alopecia Head

  REMOVED  **  CID  3121 **   REASON - Moribund
                                819 12/22/87         Ataxia
                                819 12/22/87         Ruffled Fur
                                819 12/22/87         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 4
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

313         313  506 02/12/87   506 02/12/87   1/29  Tissue Mass Body Dorsal 11-15 Mm
                 478 01/15/87   478 01/15/87   1/29  Alopecia Body Ventral

  REMOVED  **  CID  3131 **   REASON - Moribund
                                527 03/05/87         Tissue Mass Body Dorsal 26 or Gr
                                527 03/05/87         Emaciated

314         314  672 07/28/87   700 08/25/87   2/36  Tissue Mass Body Ventral  6-10 Mm

  REMOVED  **  CID  3141 **   REASON - Moribund
                                717 09/11/87         Dyspnea
                                717 09/11/87         Emaciated
                                717 09/11/87         Abnormal Posture

318         318  595 05/12/87   700 08/25/87   5/41  Tissue Mass Body (Trunk)  0- 2 Mm
                 728 09/22/87   756 10/20/87   2/41  Tissue Mass Body Ventral  0- 2 Mm

  REMOVED  **  CID  3181 **   REASON - Dead
                                849 01/21/88         Normal

320         320  534 03/12/87   567 04/14/87   2/31  Alopecia Body Ventral

  REMOVED  **  CID  3201 **   REASON - Dead
                                590 05/07/87         Normal

321         321  478 01/15/87   478 01/15/87   1/33  Alopecia Body Ventral
                 616 06/02/87   616 06/02/87   1/33  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID  3211 **   REASON - Dead
                                618 06/04/87         Normal

322         322  506 02/12/87   506 02/12/87   1/42  Alopecia Body Ventral

  REMOVED  **  CID  3221 **   REASON - Dead
                                893 03/05/88         Normal

323         323  897 03/09/88   897 03/09/88   1/43  Swelling Body Ventral

  REMOVED  **  CID  3231 **   REASON - Dead
                                920 04/01/88         Normal

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 5
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

325         325  196 04/08/86   534 03/12/87   3/30  Alopecia Entire Animal
                 140 02/11/86   478 01/15/87  11/30  Alopecia Body Ventral

  REMOVED  **  CID  3251 **   REASON - Dead
                                561 04/08/87         Normal

326         326  450 12/18/86   700 08/25/87   4/46  Tissue Mass Tail  3- 5 Mm
                 364 09/23/86   644 06/30/87   9/46  Tissue Mass Tail  0- 2 Mm
                 966 05/17/88   966 05/17/88   1/46  Tachypnea
                 966 05/17/88   966 05/17/88   1/46  Ruffled Fur
                 924 04/05/88   966 05/17/88   3/46  Tissue Mass Right Rear Leg  3- 5 Mm
                 728 09/22/87   966 05/17/88  10/46  Tissue Mass Tail  6-10 Mm

  REMOVED  **  CID  3261 **   REASON - Moribund
                                969 05/20/88         Tissue Mass Tail 11-15 Mm

327         327  534 03/12/87   616 06/02/87   4/34  Alopecia Body Ventral

  REMOVED  **  CID  3271 **   REASON - Dead
                                666 07/22/87         Normal

328         328  924 04/05/88   924 04/05/88   1/44  Tissue Mass Left Rear Leg  6-10 Mm

  REMOVED  **  CID  3281 **   REASON - Moribund
                                926 04/07/88         Tissue Mass Left Rear Leg 21-25 Mm
                                926 04/07/88         Emaciated
                                926 04/07/88         Abnormal Posture
                                926 04/07/88         Tachypnea

329         329  616 06/02/87   616 06/02/87   1/33  Dyspnea
                 616 06/02/87   616 06/02/87   1/33  Emaciated
                 616 06/02/87   616 06/02/87   1/33  Tissue Mass Neck  0- 2 Mm

  REMOVED  **  CID  3291 **   REASON - Moribund
                                621 06/07/87         Dyspnea
                                621 06/07/87         Tissue Mass Neck 11-15 Mm
                                621 06/07/87         Emaciated

332         332  534 03/12/87   616 06/02/87   4/44  Alopecia Body Ventral
                 835 01/07/88   897 03/09/88   3/44  Alopecia Hip

  REMOVED  **  CID  3321 **   REASON - Dead
                                939 04/20/88         Normal

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 6
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

333         333  835 01/07/88   980 05/31/88   7/47  Swelling Body Ventral

  REMOVED  **  CID  3331 **   REASON - Dead
                                981 06/01/88         Swelling Body Ventral

334         334  196 04/08/86   897 03/09/88  26/43  Alopecia Body Ventral

  REMOVED  **  CID  3341 **   REASON - Dead
                                912 03/24/88         Normal

335         335  924 04/05/88   924 04/05/88   1/44  Emaciated
                 616 06/02/87   616 06/02/87   1/44  Alopecia Body Dorsal

  REMOVED  **  CID  3351 **   REASON - Dead
                                931 04/12/88         Normal

336         336  868 02/09/88   868 02/09/88   1/42  Swelling Body Ventral

  REMOVED  **  CID  3361 **   REASON - Dead
                                881 02/22/88         Normal

337         337  897 03/09/88   897 03/09/88   1/43  Swelling Body Ventral
                 897 03/09/88   897 03/09/88   1/43  Ruffled Fur

  REMOVED  **  CID  3371 **   REASON - Dead
                                902 03/14/88         Normal

339         339  534 03/12/87   567 04/14/87   2/35  Alopecia Body Ventral
                 595 05/12/87   644 06/30/87   3/35  Tissue Mass Neck  0- 2 Mm
                 672 07/28/87   672 07/28/87   1/35  Tissue Mass Neck  3- 5 Mm

  REMOVED  **  CID  3391 **   REASON - Moribund
                                698 08/23/87         Tissue Mass Neck  6-10 Mm
                                698 08/23/87         Swelling Body Ventral
                                698 08/23/87         Ruffled Fur

340         340  966 05/17/88   966 05/17/88   1/46  Tachypnea
                 966 05/17/88   966 05/17/88   1/46  Emaciated
                 966 05/17/88   966 05/17/88   1/46  Ruffled Fur

  REMOVED  **  CID  3401 **   REASON - Dead

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 7
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
340         340                 969 05/20/88         Normal

344         344  805 12/08/87   805 12/08/87   1/40  Swelling Body Ventral
                 805 12/08/87   805 12/08/87   1/40  Tachypnea

  REMOVED  **  CID  3441 **   REASON - Moribund
                                818 12/21/87         Ruffled Fur
                                818 12/21/87         Tachypnea

346         346  567 04/14/87   805 12/08/87   2/40  Emaciated

  REMOVED  **  CID  3461 **   REASON - Dead
                                808 12/11/87         Normal

347         347  756 10/20/87   756 10/20/87   1/38  Emaciated
                 616 06/02/87   616 06/02/87   1/38  Tissue Mass Body (Trunk)  3- 5 Mm

  REMOVED  **  CID  3471 **   REASON - Dead
                                778 11/11/87         Normal

348         348  567 04/14/87   616 06/02/87   3/45  Alopecia Body Ventral

  REMOVED  **  CID  3481 **   REASON - Dead
                                962 05/13/88         Normal

349         349  140 02/11/86  1022 07/12/88  24/50  Alopecia Body Ventral
                 897 03/09/88   994 06/14/88   6/50  Swelling Body Ventral
                 339 08/29/86   616 06/02/87  11/50  Alopecia Entire Animal

  REMOVED  **  CID  3491 **   REASON - Term-Sac
                               1030 07/20/88         Alopecia Body Ventral

350         350  785 11/18/87   805 12/08/87   2/40  Tachypnea
                 534 03/12/87   616 06/02/87   4/40  Emaciated

  REMOVED  **  CID  3501 **   REASON - Moribund
                                820 12/23/87         Dyspnea
                                820 12/23/87         Emaciated
                                820 12/23/87         Abnormal Posture

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 8
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

352         352  567 04/14/87   616 06/02/87   3/41  Emaciated

  REMOVED  **  CID  3521 **   REASON - Dead
                                861 02/02/88         Normal

353         353  966 05/17/88   966 05/17/88   1/46  Tissue Mass Right Front Leg  6-10 Mm
                 952 05/03/88   966 05/17/88   2/46  Sore Body (Trunk)  3- 5 Mm
                 952 05/03/88   966 05/17/88   2/46  Emaciated

  REMOVED  **  CID  3531 **   REASON - Dead
                                973 05/24/88         Tissue Mass Right Front Leg 16-20 Mm
                                973 05/24/88         Emaciated
                                973 05/24/88         Sore Body Ventral 16-20 Mm

354         354  728 09/22/87   728 09/22/87   1/37  Tachypnea

  REMOVED  **  CID  3541 **   REASON - Dead
                                743 10/07/87         Normal

355         355  113 01/15/86   113 01/15/86   1/36  Alopecia Neck
                  71 12/04/85    85 12/18/85   2/36  Alopecia Face
                  85 12/18/85   113 01/15/86   2/36  Alopecia Body Dorsal
                 700 08/25/87   700 08/25/87   1/36  Hyperactive
                 140 02/11/86   616 06/02/87  18/36  Alopecia Entire Animal
                  71 12/04/85   113 01/15/86   2/36  Alopecia Body Ventral

  REMOVED  **  CID  3551 **   REASON - Moribund
                                705 08/30/87         Abnormal Posture
                                705 08/30/87         Ruffled Fur

358         358  534 03/12/87   567 04/14/87   2/41  Emaciated

  REMOVED  **  CID  3581 **   REASON - Moribund
                                855 01/27/88         Ataxia
                                855 01/27/88         Tachypnea
                                855 01/27/88         Hypoactivity

359         359  924 04/05/88   924 04/05/88   1/44  Tissue Mass Right Rear Leg 11-15 Mm
                 924 04/05/88   924 04/05/88   1/44  Emaciated

  REMOVED  **  CID  3591 **   REASON - Dead
                                930 04/11/88         Tissue Mass Right Rear Leg 26 or Gr

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 9
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

360         360  805 12/08/87   805 12/08/87   1/40  Emaciated
                 672 07/28/87   805 12/08/87   6/40  Swelling Right Eye
                 805 12/08/87   805 12/08/87   1/40  Tissue Mass Left Front Leg  6-10 Mm
                 805 12/08/87   805 12/08/87   1/40  Tachypnea
                 567 04/14/87   616 06/02/87   3/40  Alopecia Body Ventral
                 756 10/20/87   785 11/18/87   2/40  Tissue Mass Left Front Leg  3- 5 Mm

  REMOVED  **  CID  3601 **   REASON - Moribund
                                810 12/13/87         Tissue Mass Left Front Leg 16-20 Mm
                                810 12/13/87         Swelling Right Eye

362         362  196 04/08/86   966 05/17/88  21/46  Alopecia Body Ventral
                 952 05/03/88   966 05/17/88   2/46  Swelling Body Ventral
                 952 05/03/88   966 05/17/88   2/46  Tachypnea

  REMOVED  **  CID  3621 **   REASON - Moribund
                                967 05/18/88         Dyspnea
                                967 05/18/88         Emaciated
                                967 05/18/88         Abnormal Posture
                                967 05/18/88         Hypoactivity

364         364  756 10/20/87   756 10/20/87   1/38  Tissue Mass Body (Trunk) 11-15 Mm
                 728 09/22/87   756 10/20/87   2/38  Tachypnea

  REMOVED  **  CID  3641 **   REASON - Dead
                                757 10/21/87         Swelling Body Ventral

365         365  805 12/08/87   805 12/08/87   1/40  Tissue Mass Body Dorsal  6-10 Mm

  REMOVED  **  CID  3651 **   REASON - Moribund
                                820 12/23/87         Tissue Mass Body Dorsal 26 or Gr
                                820 12/23/87         Emaciated

366         366  966 05/17/88   994 06/14/88   3/48  Tissue Mass Left Rear Leg  6-10 Mm
                  85 12/18/85    85 12/18/85   1/48  Alopecia Face
                  78 12/11/85   835 01/07/88   6/48  Alopecia Body Ventral
                 140 02/11/86   994 06/14/88  24/48  Alopecia Entire Animal
                 952 05/03/88   994 06/14/88   4/48  Tachypnea

  REMOVED  **  CID  3661 **   REASON - Dead
                                998 06/18/88         Tissue Mass Left Rear Leg 21-25 Mm

367         367  728 09/22/87   728 09/22/87   1/37  Tachypnea

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 10
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
367         367  616 06/02/87   700 08/25/87   2/37  Emaciated

  REMOVED  **  CID  3671 **   REASON - Moribund
                                745 10/09/87         Tissue Mass Body Ventral 21-25 Mm
                                745 10/09/87         Emaciated

369         369  616 06/02/87   616 06/02/87   1/33  Ruffled Fur
                 616 06/02/87   616 06/02/87   1/33  Emaciated

  REMOVED  **  CID  3691 **   REASON - Dead
                                642 06/28/87         Normal

371         371  835 01/07/88   835 01/07/88   1/41  Emaciated
                 534 03/12/87   616 06/02/87   4/41  Alopecia Body Ventral
                 835 01/07/88   835 01/07/88   1/41  Tachypnea

  REMOVED  **  CID  3711 **   REASON - Moribund
                                835 01/07/88         Emaciated
                                835 01/07/88         Tachypnea
                                835 01/07/88         Hypoactivity

372         372  700 08/25/87   700 08/25/87   1/36  Sore Body Dorsal Yellow
                 700 08/25/87   700 08/25/87   1/36  Emaciated

  REMOVED  **  CID  3721 **   REASON - Moribund
                                705 08/30/87         Abnormal Posture
                                705 08/30/87         Sore Body (Trunk) Red
                                705 08/30/87         Ruffled Fur

373         373  224 05/06/86   616 06/02/87  15/48  Alopecia Entire Animal
                 897 03/09/88   897 03/09/88   1/48  Ruffled Fur
                 196 04/08/86   994 06/14/88  16/48  Alopecia Body Ventral

  REMOVED  **  CID  3731 **   REASON - Moribund
                               1007 06/27/88         Dyspnea
                               1007 06/27/88         Comatose

374         374 1008 06/28/88  1022 07/12/88   2/50  Swelling Left Eye
                1008 06/28/88  1022 07/12/88   2/50  Emaciated

  REMOVED  **  CID  3741 **   REASON - Term-Sac
                               1030 07/20/88         Swelling Left Eye

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 11
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
374         374                1030 07/20/88         Emaciated

376         376  196 04/08/86   339 08/29/86   6/30  Alopecia Body Ventral
                 364 09/23/86   534 03/12/87   7/30  Alopecia Entire Animal

  REMOVED  **  CID  3761 **   REASON - Moribund
                                555 04/02/87         Emaciated
                                555 04/02/87         Abnormal Posture
                                555 04/02/87         Limb Paralysis Right Rear Leg
                                555 04/02/87         Limb Paralysis Left Rear Leg

378         378  952 05/03/88   994 06/14/88   4/50  Tachypnea
                 897 03/09/88  1022 07/12/88   8/50  Swelling Body Ventral
                 952 05/03/88   994 06/14/88   3/50  Ruffled Fur

  REMOVED  **  CID  3781 **   REASON - Term-Sac
                               1030 07/20/88         Swelling Body Ventral

379         379  980 05/31/88   980 05/31/88   1/47  Tachypnea
                 980 05/31/88   980 05/31/88   1/47  Ruffled Fur

  REMOVED  **  CID  3791 **   REASON - Dead
                                993 06/13/88         Tissue Mass Body Ventral 16-20 Mm

380         380   15 10/09/85    15 10/09/85   1/50  Override
                 835 01/07/88   835 01/07/88   1/50  Exophthalmos
                 952 05/03/88  1022 07/12/88   6/50  Swelling Left Eye
                1022 07/12/88  1022 07/12/88   1/50  Swelling Body Ventral
                1008 06/28/88  1022 07/12/88   2/50  Discharge Left Eye

  REMOVED  **  CID  3801 **   REASON - Term-Sac
                               1030 07/20/88         Swelling Left Eye
                               1030 07/20/88         Discharge Left Eye

382         382  924 04/05/88   924 04/05/88   1/44  Emaciated
                 924 04/05/88   924 04/05/88   1/44  Sore Body (Trunk)  6-10 Mm

  REMOVED  **  CID  3821 **   REASON - Moribund
                                945 04/26/88         Emaciated
                                945 04/26/88         Hyperactive
                                945 04/26/88         Abnormal Posture
                                945 04/26/88         Wound Body Ventral 16-20 Mm

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 12
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
382         382                 945 04/26/88         Tachypnea

384         384  364 09/23/86   616 06/02/87  10/41  Alopecia Entire Animal
                 140 02/11/86   835 01/07/88  15/41  Alopecia Body Ventral
                 756 10/20/87   756 10/20/87   1/41  Tissue Mass Body Dorsal  6-10 Mm
                 835 01/07/88   835 01/07/88   1/41  Emaciated

  REMOVED  **  CID  3841 **   REASON - Moribund
                                859 01/31/88         Swelling Body Ventral
                                859 01/31/88         Abnormal Posture
                                859 01/31/88         Hypoactivity

385         385  785 11/18/87   785 11/18/87   1/39  Tachypnea
                 785 11/18/87   785 11/18/87   1/39  Emaciated
                 785 11/18/87   785 11/18/87   1/39  Swelling Body Ventral

  REMOVED  **  CID  3851 **   REASON - Moribund
                                802 12/05/87         Tissue Mass Body Ventral 26 or Gr
                                802 12/05/87         Abnormal Posture

386         386  534 03/12/87   700 08/25/87   4/36  Emaciated

  REMOVED  **  CID  3861 **   REASON - Moribund
                                705 08/30/87         Dyspnea
                                705 08/30/87         Emaciated
                                705 08/30/87         Abnormal Posture
                                705 08/30/87         Ruffled Fur
                                705 08/30/87         Hypoactivity

387         387  224 05/06/86   756 10/20/87  19/39  Alopecia Body Ventral
                 785 11/18/87   785 11/18/87   1/39  Alopecia Entire Animal

  REMOVED  **  CID  3871 **   REASON - Moribund
                                793 11/26/87         Tissue Mass Body Dorsal  6-10 Mm
                                793 11/26/87         Swelling Body Ventral

389         389  567 04/14/87   616 06/02/87   3/40  Alopecia Body Ventral

  REMOVED  **  CID  3891 **   REASON - Moribund
                                827 12/30/87         Ataxia
                                827 12/30/87         Tachypnea
                                827 12/30/87         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 13
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

390         390  924 04/05/88   952 05/03/88   2/45  Swelling Body Ventral

  REMOVED  **  CID  3901 **   REASON - Moribund
                                956 05/07/88         Tachypnea
                                956 05/07/88         Comatose

392         392  309 07/30/86   616 06/02/87   9/44  Alopecia Body Ventral
                 924 04/05/88   924 04/05/88   1/44  Ruffled Fur
                 506 02/12/87   567 04/14/87   3/44  Alopecia Entire Animal
                 897 03/09/88   924 04/05/88   2/44  Swelling Body Ventral
                 924 04/05/88   924 04/05/88   1/44  Emaciated

  REMOVED  **  CID  3921 **   REASON - Dead
                                944 04/25/88         Normal

393         393  835 01/07/88   835 01/07/88   1/41  Emaciated
                 534 03/12/87   616 06/02/87   4/41  Alopecia Entire Animal
                 835 01/07/88   835 01/07/88   1/41  Tachypnea

  REMOVED  **  CID  3931 **   REASON - Moribund
                                842 01/14/88         Emaciated
                                842 01/14/88         Abnormal Posture
                                842 01/14/88         Tachypnea

394         394  994 06/14/88   994 06/14/88   1/50  Tissue Mass Body (Trunk)  3- 5 Mm
                1022 07/12/88  1022 07/12/88   1/50  Tissue Mass Right Front Leg 26 or Gr
                1008 06/28/88  1008 06/28/88   1/50  Tissue Mass Left Front Leg 11-15 Mm
                 966 05/17/88   980 05/31/88   2/50  Tissue Mass Right Front Leg  6-10 Mm

  REMOVED  **  CID  3941 **   REASON - Term-Sac
                               1030 07/20/88         Tissue Mass Left Front Leg 11-15 Mm

395         395  952 05/03/88   966 05/17/88   2/46  Ruffled Fur
                 952 05/03/88   966 05/17/88   2/46  Tachypnea
                 966 05/17/88   966 05/17/88   1/46  Emaciated

  REMOVED  **  CID  3951 **   REASON - Dead
                                980 05/31/88         Normal

396         396  567 04/14/87   595 05/12/87   2/32  Alopecia Body Ventral

  REMOVED  **  CID  3961 **   REASON - Dead

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 14
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
396         396                 600 05/17/87         Normal

397         397  868 02/09/88   868 02/09/88   1/42  Emaciated
                 868 02/09/88   868 02/09/88   1/42  Tachypnea
                 364 09/23/86   364 09/23/86   1/42  Alopecia Right Rear Leg
                 616 06/02/87   616 06/02/87   1/42  Alopecia Body (Trunk)

  REMOVED  **  CID  3971 **   REASON - Moribund
                                872 02/13/88         Dyspnea
                                872 02/13/88         Tissue Mass Skin  6-10 Mm
                                872 02/13/88         Emaciated
                                872 02/13/88         Abnormal Posture

400         400  309 07/30/86   616 06/02/87   8/37  Alopecia Body Ventral
                 616 06/02/87   616 06/02/87   1/37  Ruffled Fur
                 364 09/23/86   450 12/18/86   4/37  Alopecia Entire Animal

  REMOVED  **  CID  4001 **   REASON - Moribund
                                749 10/13/87         Head Tilted
                                749 10/13/87         Tachypnea

402         402  567 04/14/87   616 06/02/87   3/40  Alopecia Body Ventral

  REMOVED  **  CID  4021 **   REASON - Moribund
                                814 12/17/87         Comatose

403         403 1022 07/12/88  1022 07/12/88   1/50  Emaciated
                1022 07/12/88  1022 07/12/88   1/50  Ruffled Fur
                1022 07/12/88  1022 07/12/88   1/50  Tachypnea

  REMOVED  **  CID  4031 **   REASON - Moribund
                               1024 07/14/88         Emaciated
                               1024 07/14/88         Comatose

408         408  756 10/20/87   756 10/20/87   1/38  Emaciated

  REMOVED  **  CID  4081 **   REASON - Moribund
                                763 10/27/87         Tissue Mass Face 11-15 Mm
                                763 10/27/87         Emaciated
                                763 10/27/87         Abnormal Posture

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 15
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

409         409  835 01/07/88   835 01/07/88   1/41  Tissue Mass Shoulder  6-10 Mm

  REMOVED  **  CID  4091 **   REASON - Moribund
                                851 01/23/88         Tissue Mass Shoulder  6-10 Mm
                                851 01/23/88         Swelling Body Ventral
                                851 01/23/88         Ruffled Fur

410         410  168 03/11/86  1022 07/12/88  34/50  Alopecia Body Ventral
                 534 03/12/87   616 06/02/87   4/50  Sore Right Ear  0- 2 Mm

  REMOVED  **  CID  4101 **   REASON - Term-Sac
                               1030 07/20/88         Alopecia Body Ventral

411         411 1008 06/28/88  1008 06/28/88   1/49  Swelling Body Ventral

  REMOVED  **  CID  4111 **   REASON - Moribund
                               1018 07/08/88         Dyspnea
                               1018 07/08/88         Swelling Body Ventral
                               1018 07/08/88         Abnormal Posture

413         413  728 09/22/87   728 09/22/87   1/37  Tissue Mass Body (Trunk) 11-15 Mm

  REMOVED  **  CID  4131 **   REASON - Moribund
                                747 10/11/87         Tissue Mass Body (Trunk) 26 or Gr

414         414  924 04/05/88   924 04/05/88   1/44  Tissue Mass Body Dorsal  6-10 Mm

  REMOVED  **  CID  4141 **   REASON - Dead
                                927 04/08/88         Tissue Mass Body Dorsal 11-15 Mm

416         416  196 04/08/86   644 06/30/87  16/34  Malocclusion
                 644 06/30/87   644 06/30/87   1/34  Emaciated
                 196 04/08/86   644 06/30/87  17/34  Swelling Nose

  REMOVED  **  CID  4161 **   REASON - Moribund
                                667 07/23/87         Swelling Face
                                667 07/23/87         Ataxia
                                667 07/23/87         Ruffled Fur
                                667 07/23/87         Hypoactivity

417         417  672 07/28/87   672 07/28/87   1/35  Tissue Mass Body (Trunk) 26 or Gr

  REMOVED  **  CID  4171 **   REASON - Moribund

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 16
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
417         417                 672 07/28/87         Dyspnea
                                672 07/28/87         Swelling Body Ventral
                                672 07/28/87         Emaciated

420         420  420 11/18/86   420 11/18/86   1/26  Swelling Body Ventral

  REMOVED  **  CID  4201 **   REASON - Moribund
                                422 11/20/86         Swelling Body Ventral

421         421  567 04/14/87   567 04/14/87   1/31  Emaciated

  REMOVED  **  CID  4211 **   REASON - Dead
                                572 04/19/87         Normal

422         422  835 01/07/88   835 01/07/88   1/46  Emaciated
                 835 01/07/88   835 01/07/88   1/46  Tachypnea
                 952 05/03/88   966 05/17/88   2/46  Tissue Mass Neck  6-10 Mm

  REMOVED  **  CID  4221 **   REASON - Moribund
                                967 05/18/88         Tissue Mass Neck 21-25 Mm
                                967 05/18/88         Abnormal Posture
                                967 05/18/88         Ruffled Fur
                                967 05/18/88         Hypoactivity

423         423  595 05/12/87   616 06/02/87   2/50  Emaciated
                1022 07/12/88  1022 07/12/88   1/50  Ruffled Fur
                1022 07/12/88  1022 07/12/88   1/50  Tachypnea

  REMOVED  **  CID  4231 **   REASON - Term-Sac
                               1030 07/20/88         Normal

424         424  924 04/05/88   924 04/05/88   1/44  Tissue Mass Right Front Leg  6-10 Mm

  REMOVED  **  CID  4241 **   REASON - Moribund
                                932 04/13/88         Tissue Mass Body Dorsal 16-20 Mm
                                932 04/13/88         Tachypnea
                                932 04/13/88         Comatose

425         425  282 07/03/86   534 03/12/87  10/30  Alopecia Body Ventral
                 478 01/15/87   478 01/15/87   1/30  Dyspnea
                 450 12/18/86   450 12/18/86   1/30  Tachypnea

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 17
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
425         425  140 02/11/86   140 02/11/86   1/30  Alopecia Left Front Leg

  REMOVED  **  CID  4251 **   REASON - Dead
                                550 03/28/87         Jaundice

426         426  420 11/18/86   616 06/02/87   8/41  Alopecia Body Ventral

  REMOVED  **  CID  4261 **   REASON - Moribund
                                847 01/19/88         Head Tilted
                                847 01/19/88         Abnormal Posture
                                847 01/19/88         Ruffled Fur
                                847 01/19/88         Tachypnea

427         427  756 10/20/87   756 10/20/87   1/38  Emaciated
                 253 06/04/86   756 10/20/87  18/38  Alopecia Body Ventral
                 140 02/11/86   224 05/06/86   4/38  Alopecia Entire Animal

  REMOVED  **  CID  4271 **   REASON - Moribund
                                758 10/22/87         Hypoactivity

430         430  966 05/17/88   966 05/17/88   1/46  Emaciated
                 966 05/17/88   966 05/17/88   1/46  Ruffled Fur

  REMOVED  **  CID  4301 **   REASON - Moribund
                                967 05/18/88         Emaciated
                                967 05/18/88         Abnormal Posture
                                967 05/18/88         Tachypnea
                                967 05/18/88         Hypoactivity

434         434  952 05/03/88   952 05/03/88   1/45  Emaciated

  REMOVED  **  CID  4341 **   REASON - Moribund
                                954 05/05/88         Tremors
                                954 05/05/88         Emaciated
                                954 05/05/88         Ataxia
                                954 05/05/88         Hypoactivity

435         435  168 03/11/86  1022 07/12/88  32/50  Alopecia Body Ventral

  REMOVED  **  CID  4351 **   REASON - Term-Sac
                               1030 07/20/88         Alopecia Body Ventral

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 18
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

436         436  534 03/12/87   616 06/02/87   4/49  Alopecia Body Ventral

  REMOVED  **  CID  4361 **   REASON - Dead
                               1016 07/06/88         Normal

437         437  616 06/02/87   616 06/02/87   1/36  Alopecia Body Ventral

  REMOVED  **  CID  4371 **   REASON - Dead
                                722 09/16/87         Tissue Mass Neck 16-20 Mm

438         438  506 02/12/87   616 06/02/87   5/33  Alopecia Body Ventral

  REMOVED  **  CID  4381 **   REASON - Dead
                                638 06/24/87         Normal

439         439  897 03/09/88   897 03/09/88   1/43  Emaciated
                 897 03/09/88   897 03/09/88   1/43  Tachypnea

  REMOVED  **  CID  4391 **   REASON - Dead
                                908 03/20/88         Normal

441         441  672 07/28/87   672 07/28/87   1/39  Emaciated
                 450 12/18/86   728 09/22/87  11/39  Discharge Right Eye
                 450 12/18/86   728 09/22/87  11/39  Swelling Right Eye
                 756 10/20/87   785 11/18/87   2/39  Tissue Mass Right Eye  6-10 Mm
                 450 12/18/86   644 06/30/87   8/39  Ulcer Right Eye  0- 2 Mm
                 785 11/18/87   785 11/18/87   1/39  Tachypnea

  REMOVED  **  CID  4411 **   REASON - Moribund
                                788 11/21/87         Tissue Mass Right Eye  6-10 Mm

442         442  616 06/02/87   616 06/02/87   1/36  Tissue Mass Body (Trunk)  0- 2 Mm
                 506 02/12/87   616 06/02/87   5/36  Emaciated
                 644 06/30/87   644 06/30/87   1/36  Reddened Right Front Leg
                 700 08/25/87   700 08/25/87   1/36  Sore Neck Yellow
                 672 07/28/87   672 07/28/87   1/36  Sore Right Front Leg Red

  REMOVED  **  CID  4421 **   REASON - Moribund
                                705 08/30/87         Abnormal Posture
                                705 08/30/87         Wound Neck Red
                                705 08/30/87         Ruffled Fur

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 19
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

444         444  952 05/03/88   952 05/03/88   1/45  Swelling Body Ventral

  REMOVED  **  CID  4441 **   REASON - Dead
                                954 05/05/88         Normal

446         446 1008 06/28/88  1008 06/28/88   1/49  Swelling Body Ventral
                1008 06/28/88  1008 06/28/88   1/49  Ruffled Fur

  REMOVED  **  CID  4461 **   REASON - Moribund
                               1009 06/29/88         Tremors
                               1009 06/29/88         Abnormal Posture
                               1009 06/29/88         Tachypnea
                               1009 06/29/88         Hypoactivity

447         447  805 12/08/87   805 12/08/87   1/40  Hyperactive
                 805 12/08/87   805 12/08/87   1/40  Head Tilted
                 805 12/08/87   805 12/08/87   1/40  Emaciated

  REMOVED  **  CID  4471 **   REASON - Dead
                                813 12/16/87         Normal

450         450  567 04/14/87   616 06/02/87   3/50  Alopecia Body Ventral
                1022 07/12/88  1022 07/12/88   1/50  Tissue Mass Neck 11-15 Mm

  REMOVED  **  CID  4501 **   REASON - Term-Sac
                               1030 07/20/88         Tissue Mass Neck 11-15 Mm

451         451  805 12/08/87   805 12/08/87   1/40  Tissue Mass Shoulder  6-10 Mm

  REMOVED  **  CID  4511 **   REASON - Moribund
                                820 12/23/87         Tissue Mass Body Ventral 26 or Gr
                                820 12/23/87         Emaciated
                                820 12/23/87         Abnormal Posture

452         452  309 07/30/86   339 08/29/86   2/39  Alopecia Body Ventral
                 140 02/11/86   616 06/02/87  15/39  Alopecia Entire Animal

  REMOVED  **  CID  4521 **   REASON - Dead
                                798 12/01/87         Normal

454         454  966 05/17/88   980 05/31/88   2/48  Swelling Body Ventral

  REMOVED  **  CID  4541 **   REASON - Dead

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 20
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
454         454                1008 06/28/88         Swelling Body Ventral

455         455  506 02/12/87   616 06/02/87   5/50  Alopecia Entire Animal
                 282 07/03/86   478 01/15/87   8/50  Alopecia Right Rear Leg
                1022 07/12/88  1022 07/12/88   1/50  Emaciated
                1022 07/12/88  1022 07/12/88   1/50  Tissue Mass Right Rear Leg 16-20 Mm
                 420 11/18/86   478 01/15/87   3/50  Alopecia Body Ventral
                1022 07/12/88  1022 07/12/88   1/50  Ruffled Fur
                1022 07/12/88  1022 07/12/88   1/50  Tachypnea

  REMOVED  **  CID  4551 **   REASON - Term-Sac
                               1030 07/20/88         Tissue Mass Right Rear Leg 16-20 Mm

456         456  534 03/12/87   567 04/14/87   2/31  Alopecia Body Ventral
                 567 04/14/87   567 04/14/87   1/31  Limb Paralysis Left Rear Foot

  REMOVED  **  CID  4561 **   REASON - Dead
                                569 04/16/87         Limb Paralysis Right Rear Leg

458         458  952 05/03/88   952 05/03/88   1/45  Ruffled Fur
                 952 05/03/88   952 05/03/88   1/45  Tachypnea

  REMOVED  **  CID  4581 **   REASON - Moribund
                                955 05/06/88         Abnormal Posture
                                955 05/06/88         Ruffled Fur
                                955 05/06/88         Tachypnea
                                955 05/06/88         Hypoactivity

459         459  924 04/05/88   980 05/31/88   4/48  Swelling Body Ventral
                 980 05/31/88   994 06/14/88   2/48  Sore Body Dorsal  6-10 Mm
                 980 05/31/88   994 06/14/88   2/48  Tachypnea
                 966 05/17/88   966 05/17/88   1/48  Sore Body Dorsal  3- 5 Mm
                 980 05/31/88   994 06/14/88   2/48  Emaciated

  REMOVED  **  CID  4591 **   REASON - Dead
                               1001 06/21/88         Tissue Mass Body Dorsal 16-20 Mm

461         461  868 02/09/88   868 02/09/88   1/42  Tissue Mass Shoulder  3- 5 Mm

  REMOVED  **  CID  4611 **   REASON - Moribund
                                896 03/08/88         Tissue Mass Body (Trunk) 26 or Gr
                                896 03/08/88         Abnormal Posture

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 21
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
461         461                 896 03/08/88         Tachypnea

462         462  835 01/07/88   868 02/09/88   2/42  Sore Body Dorsal  6-10 Mm
                 868 02/09/88   868 02/09/88   1/42  Emaciated

  REMOVED  **  CID  4621 **   REASON - Moribund
                                891 03/03/88         Emaciated
                                891 03/03/88         Abnormal Posture
                                891 03/03/88         Sore Body (Trunk) 21-25 Mm
                                891 03/03/88         Tachypnea

463         463  567 04/14/87   616 06/02/87   3/42  Alopecia Body Ventral
                 868 02/09/88   868 02/09/88   1/42  Emaciated

  REMOVED  **  CID  4631 **   REASON - Accident
                                880 02/21/88         Emaciated

464         464  616 06/02/87   616 06/02/87   1/33  Emaciated

  REMOVED  **  CID  4641 **   REASON - Moribund
                                618 06/04/87         Emaciated

465         465  450 12/18/86   616 06/02/87   7/45  Alopecia Body Ventral
                 897 03/09/88   952 05/03/88   3/45  Swelling Body Ventral

  REMOVED  **  CID  4651 **   REASON - Moribund
                                953 05/04/88         Ataxia
                                953 05/04/88         Tachypnea
                                953 05/04/88         Hypoactivity

468         468  364 09/23/86   835 01/07/88  16/50  Alopecia Entire Animal
                 339 08/29/86  1022 07/12/88  12/50  Alopecia Body Ventral
                1022 07/12/88  1022 07/12/88   1/50  Tachypnea

  REMOVED  **  CID  4681 **   REASON - Term-Sac
                               1030 07/20/88         Alopecia Body Ventral

469         469  506 02/12/87   616 06/02/87   5/40  Alopecia Body Ventral

  REMOVED  **  CID  4691 **   REASON - Dead
                                828 12/31/87         Normal

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 22
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

470         470  868 02/09/88   868 02/09/88   1/42  Swelling Body Ventral

  REMOVED  **  CID  4701 **   REASON - Moribund
                                890 03/02/88         Diarrhea
                                890 03/02/88         Abnormal Posture
                                890 03/02/88         Tachypnea

473         473  567 04/14/87   616 06/02/87   3/45  Alopecia Entire Animal
                 420 11/18/86   534 03/12/87   5/45  Alopecia Body Ventral
                 924 04/05/88   952 05/03/88   2/45  Ruffled Fur
                 952 05/03/88   952 05/03/88   1/45  Emaciated

  REMOVED  **  CID  4731 **   REASON - Dead
                                966 05/17/88         Normal

476         476  805 12/08/87   805 12/08/87   1/40  Tissue Mass Shoulder  6-10 Mm
                 616 06/02/87   616 06/02/87   1/40  Emaciated
                 756 10/20/87   785 11/18/87   2/40  Tissue Mass Body (Trunk)  6-10 Mm

  REMOVED  **  CID  4761 **   REASON - Moribund
                                809 12/12/87         Tissue Mass Body Ventral 16-20 Mm
                                809 12/12/87         Ataxia
                                809 12/12/87         Abnormal Posture

478         478  835 01/07/88   868 02/09/88   2/42  Swelling Left Eye
                 835 01/07/88   868 02/09/88   2/42  Discharge Left Eye

  REMOVED  **  CID  4781 **   REASON - Moribund
                                884 02/25/88         Emaciated
                                884 02/25/88         Abnormal Posture
                                884 02/25/88         Tachypnea
                                884 02/25/88         Hypoactivity

479         479 1022 07/12/88  1022 07/12/88   1/50  Swelling Body Ventral
                 339 08/29/86   339 08/29/86   1/50  Emaciated

  REMOVED  **  CID  4791 **   REASON - Dead
                               1026 07/16/88         Normal

480         480  567 04/14/87   567 04/14/87   1/31  Emaciated

  REMOVED  **  CID  4801 **   REASON - Moribund

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 23
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
480         480                 585 05/02/87         Dyspnea
                                585 05/02/87         Emaciated
                                585 05/02/87         Abnormal Posture
                                585 05/02/87         Hypoactivity

481         481  868 02/09/88   868 02/09/88   1/42  Tissue Mass Shoulder  3- 5 Mm
                 309 07/30/86   672 07/28/87   3/42  Alopecia Body Ventral
                 140 02/11/86   140 02/11/86   1/42  Alopecia Body (Trunk)
                 168 03/11/86   868 02/09/88  23/42  Alopecia Entire Animal

  REMOVED  **  CID  4811 **   REASON - Moribund
                                877 02/18/88         Abnormal Posture
                                877 02/18/88         Tachypnea
                                877 02/18/88         Hypoactivity

483         483  952 05/03/88   952 05/03/88   1/45  Tissue Mass Right Front Leg  6-10 Mm

  REMOVED  **  CID  4831 **   REASON - Dead
                                965 05/16/88         Tissue Mass Right Front Leg 16-20 Mm

484         484  567 04/14/87   616 06/02/87   3/35  Alopecia Entire Animal
                 450 12/18/86   534 03/12/87   4/35  Alopecia Body Ventral

  REMOVED  **  CID  4841 **   REASON - Moribund
                                695 08/20/87         Emaciated
                                695 08/20/87         Ataxia
                                695 08/20/87         Abnormal Posture
                                695 08/20/87         Ruffled Fur
                                695 08/20/87         Hypoactivity

485         485  534 03/12/87   595 05/12/87   3/32  Emaciated

  REMOVED  **  CID  4851 **   REASON - Moribund
                                605 05/22/87         Swelling Body Ventral

486         486  897 03/09/88   924 04/05/88   2/44  Ruffled Fur
                 868 02/09/88   868 02/09/88   1/44  Emaciated
                 897 03/09/88   924 04/05/88   2/44  Swelling Body Ventral

  REMOVED  **  CID  4861 **   REASON - Moribund
                                932 04/13/88         Swelling Body Ventral
                                932 04/13/88         Abnormal Posture

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 24
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
486         486                 932 04/13/88         Ruffled Fur
                                932 04/13/88         Tachypnea
                                932 04/13/88         Hypoactivity

488         488  868 02/09/88   868 02/09/88   1/42  Tachypnea
                 868 02/09/88   868 02/09/88   1/42  Head Tilted

  REMOVED  **  CID  4881 **   REASON - Moribund
                                883 02/24/88         Emaciated
                                883 02/24/88         Abnormal Posture
                                883 02/24/88         Tachypnea
                                883 02/24/88         Hypoactivity

489         489  450 12/18/86   616 06/02/87   7/43  Alopecia Right Rear Leg
                 616 06/02/87   616 06/02/87   1/43  Alopecia Left Rear Leg

  REMOVED  **  CID  4891 **   REASON - Dead
                                913 03/25/88         Normal

490         490  253 06/04/86   616 06/02/87  13/44  Alopecia Entire Animal
                 196 04/08/86   224 05/06/86   2/44  Alopecia Body Ventral

  REMOVED  **  CID  4901 **   REASON - Dead
                                951 05/02/88         Normal

491         491  785 11/18/87   868 02/09/88   4/42  Swelling Body Ventral
                 868 02/09/88   868 02/09/88   1/42  Emaciated
                 785 11/18/87   868 02/09/88   4/42  Tachypnea

  REMOVED  **  CID  4911 **   REASON - Moribund
                                873 02/14/88         Abnormal Posture
                                873 02/14/88         Tachypnea

492         492  756 10/20/87   756 10/20/87   1/38  Tissue Mass Body (Trunk)  6-10 Mm

  REMOVED  **  CID  4921 **   REASON - Moribund
                                765 10/29/87         Tissue Mass Body (Trunk) 21-25 Mm
                                765 10/29/87         Ruffled Fur
                                765 10/29/87         Tachypnea
                                765 10/29/87         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 25
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

493         493  835 01/07/88   835 01/07/88   1/41  Emaciated

  REMOVED  **  CID  4931 **   REASON - Dead
                                852 01/24/88         Normal

494         494  450 12/18/86   478 01/15/87   2/40  Swelling Tail
                 534 03/12/87   700 08/25/87   7/40  Tissue Mass Tail  0- 2 Mm
                 785 11/18/87   785 11/18/87   1/40  Tissue Mass Tail  6-10 Mm
                 728 09/22/87   805 12/08/87   3/40  Tissue Mass Tail  3- 5 Mm
                 785 11/18/87   785 11/18/87   1/40  Emaciated
                 805 12/08/87   805 12/08/87   1/40  Tissue Mass Neck  3- 5 Mm
                 805 12/08/87   805 12/08/87   1/40  Swelling Left Eye

  REMOVED  **  CID  4941 **   REASON - Moribund
                                817 12/20/87         Tissue Mass Right Eye  6-10 Mm
                                817 12/20/87         Tissue Mass Neck  6-10 Mm
                                817 12/20/87         Emaciated
                                817 12/20/87         Abnormal Posture
                                817 12/20/87         Ruffled Fur
                                817 12/20/87         Hypoactivity

497         497  364 09/23/86   364 09/23/86   1/40  Alopecia Right Rear Leg

  REMOVED  **  CID  4971 **   REASON - Dead
                                814 12/17/87         Normal

498         498  952 05/03/88   980 05/31/88   3/47  Head Tilted
                 952 05/03/88   980 05/31/88   3/47  Emaciated
                 952 05/03/88   980 05/31/88   3/47  Tachypnea

  REMOVED  **  CID  4981 **   REASON - Moribund
                                991 06/11/88         Dyspnea
                                991 06/11/88         Emaciated
                                991 06/11/88         Abnormal Posture

500         500  868 02/09/88   868 02/09/88   1/42  Swelling Body Ventral

  REMOVED  **  CID  5001 **   REASON - Moribund
                                878 02/19/88         Abnormal Posture
                                878 02/19/88         Tachypnea
                                878 02/19/88         Hypoactivity

504         504  700 08/25/87   700 08/25/87   1/36  Emaciated

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 26
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

  REMOVED  **  CID  5041 **   REASON - Dead
504         504                 705 08/30/87         Normal

505         505  395 10/24/86   534 03/12/87   6/35  Alopecia Right Rear Leg
                 567 04/14/87   616 06/02/87   3/35  Alopecia Entire Animal
                 364 09/23/86   506 02/12/87   6/35  Alopecia Left Rear Leg
                 534 03/12/87   534 03/12/87   1/35  Alopecia Left Rear Foot
                 309 07/30/86   339 08/29/86   2/35  Alopecia Body Dorsal

  REMOVED  **  CID  5051 **   REASON - Moribund
                                688 08/13/87         Dyspnea
                                688 08/13/87         Ruffled Fur
                                688 08/13/87         Hypoactivity

506         506  253 06/04/86   616 06/02/87  14/42  Alopecia Entire Animal
                 196 04/08/86   700 08/25/87   5/42  Alopecia Body Ventral
                 868 02/09/88   868 02/09/88   1/42  Tissue Mass Body (Trunk) 26 or Gr

  REMOVED  **  CID  5061 **   REASON - Moribund
                                868 02/09/88         Tissue Mass Left Rear Leg 26 or Gr
                                868 02/09/88         Ruffled Fur
                                868 02/09/88         Tachypnea
                                868 02/09/88         Hypoactivity

507         507  450 12/18/86   506 02/12/87   3/50  Alopecia Left Rear Leg
                 534 03/12/87   616 06/02/87   4/50  Alopecia Entire Animal
                 339 08/29/86  1022 07/12/88  24/50  Alopecia Body Ventral

  REMOVED  **  CID  5071 **   REASON - Term-Sac
                               1030 07/20/88         Alopecia Body Ventral

508         508  196 04/08/86   339 08/29/86   6/34  Alopecia Entire Animal
                 140 02/11/86   140 02/11/86   1/34  Alopecia Body Dorsal
                 140 02/11/86   616 06/02/87   6/34  Alopecia Body Ventral

  REMOVED  **  CID  5081 **   REASON - Dead
                                661 07/17/87         Salivating

509         509  140 02/11/86   168 03/11/86   2/29  Alopecia Body Dorsal
                 196 04/08/86   478 01/15/87  11/29  Alopecia Entire Animal

  REMOVED  **  CID  5091 **   REASON - Dead

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 27
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
509         509                 510 02/16/87         Normal

510         510  897 03/09/88   924 04/05/88   2/44  Tissue Mass Body (Trunk)  6-10 Mm

  REMOVED  **  CID  5101 **   REASON - Dead
                                939 04/20/88         Swelling Body (Trunk)

511         511  567 04/14/87   616 06/02/87   3/50  Emaciated
                1022 07/12/88  1022 07/12/88   1/50  Ruffled Fur
                1022 07/12/88  1022 07/12/88   1/50  Tachypnea

  REMOVED  **  CID  5111 **   REASON - Term-Sac
                               1030 07/20/88         Normal

515         515   57 11/20/85    78 12/11/85   5/25  Alopecia Body Dorsal
                  78 12/11/85    78 12/11/85   1/25  Alopecia Body (Trunk)
                  86 12/19/85   395 10/24/86  13/25  Alopecia Entire Animal
                  64 11/27/85    78 12/11/85   3/25  Alopecia Body Ventral
                  71 12/04/85    78 12/11/85   2/25  Alopecia Face

  REMOVED  **  CID  5151 **   REASON - Dead
                                408 11/06/86         Swelling Body Ventral

517         517  868 02/09/88   868 02/09/88   1/42  Tachypnea
                 868 02/09/88   868 02/09/88   1/42  Swelling Body Ventral
                 868 02/09/88   868 02/09/88   1/42  Ruffled Fur

  REMOVED  **  CID  5171 **   REASON - Moribund
                                872 02/13/88         Dyspnea
                                872 02/13/88         Swelling Body Ventral

520         520  980 05/31/88   980 05/31/88   1/47  Tachypnea
                 897 03/09/88   897 03/09/88   1/47  Swelling Body Ventral
                 980 05/31/88   980 05/31/88   1/47  Head Tilted
                 980 05/31/88   980 05/31/88   1/47  Emaciated

  REMOVED  **  CID  5201 **   REASON - Moribund
                                983 06/03/88         Dyspnea
                                983 06/03/88         Emaciated
                                983 06/03/88         Abnormal Posture

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 28
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

521         521  534 03/12/87   616 06/02/87   4/36  Alopecia Body Ventral

  REMOVED  **  CID  5211 **   REASON - Dead
                                701 08/26/87         Normal

522         522  196 04/08/86   478 01/15/87   6/50  Alopecia Body Ventral
                 309 07/30/86   616 06/02/87   9/50  Alopecia Entire Animal

  REMOVED  **  CID  5221 **   REASON - Term-Sac
                               1030 07/20/88         Normal

523         523  224 05/06/86   282 07/03/86   3/35  Alopecia Body Ventral
                 309 07/30/86   616 06/02/87  12/35  Alopecia Entire Animal

  REMOVED  **  CID  5231 **   REASON - Dead
                                680 08/05/87         Alopecia Body Ventral

524         524  897 03/09/88   924 04/05/88   2/44  Emaciated
                 534 03/12/87   616 06/02/87   4/44  Alopecia Body Ventral
                 924 04/05/88   924 04/05/88   1/44  Head Tilted

  REMOVED  **  CID  5241 **   REASON - Moribund
                                933 04/14/88         Tremors
                                933 04/14/88         Emaciated
                                933 04/14/88         Abnormal Posture
                                933 04/14/88         Tachypnea
                                933 04/14/88         Hypoactivity

525         525  897 03/09/88   966 05/17/88   4/46  Swelling Body Ventral

  REMOVED  **  CID  5251 **   REASON - Dead
                                980 05/31/88         Swelling Body Ventral

526         526  113 01/15/86   616 06/02/87  19/35  Alopecia Entire Animal
                 644 06/30/87   672 07/28/87   2/35  Alopecia Body Ventral

  REMOVED  **  CID  5261 **   REASON - Moribund
                                694 08/19/87         Emaciated
                                694 08/19/87         Abnormal Posture
                                694 08/19/87         Hypoactivity

527         527  364 09/23/86   805 12/08/87  13/40  Alopecia Body Ventral

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 29
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
527         527  168 03/11/86   616 06/02/87  11/40  Alopecia Entire Animal

  REMOVED  **  CID  5271 **   REASON - Dead
                                825 12/28/87         Normal

528         528  644 06/30/87   644 06/30/87   1/34  Tissue Mass Mammary  6-10 Mm

  REMOVED  **  CID  5281 **   REASON - Moribund
                                650 07/06/87         Tissue Mass Body Ventral 26 or Gr
                                650 07/06/87         Emaciated

529         529  952 05/03/88   952 05/03/88   1/45  Swelling Body Ventral
                 952 05/03/88   952 05/03/88   1/45  Tachypnea
                 952 05/03/88   952 05/03/88   1/45  Emaciated

  REMOVED  **  CID  5291 **   REASON - Moribund
                                953 05/04/88         Tremors
                                953 05/04/88         Abnormal Posture
                                953 05/04/88         Ruffled Fur
                                953 05/04/88         Tachypnea
                                953 05/04/88         Hypoactivity

531         531 1022 07/12/88  1022 07/12/88   1/50  Tachypnea
                1022 07/12/88  1022 07/12/88   1/50  Swelling Body Ventral
                1022 07/12/88  1022 07/12/88   1/50  Ruffled Fur
                 506 02/12/87  1022 07/12/88   2/50  Abnormal Posture

  REMOVED  **  CID  5311 **   REASON - Term-Sac
                               1030 07/20/88         Normal

533         533  339 08/29/86   339 08/29/86   1/45  Alopecia Body Ventral
                 897 03/09/88   952 05/03/88   3/45  Swelling Body Ventral
                 897 03/09/88   897 03/09/88   1/45  Tachypnea
                 897 03/09/88   897 03/09/88   1/45  Ruffled Fur
                 897 03/09/88   897 03/09/88   1/45  Emaciated

  REMOVED  **  CID  5331 **   REASON - Moribund
                                962 05/13/88         Tachypnea
                                962 05/13/88         Hypoactivity

534         534  756 10/20/87   756 10/20/87   1/39  Tissue Mass Body Dorsal  6-10 Mm
                 785 11/18/87   785 11/18/87   1/39  Tissue Mass Neck  6-10 Mm

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 30
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

  REMOVED  **  CID  5341 **   REASON - Dead
534         534                 804 12/07/87         Tissue Mass Neck 11-15 Mm

535         535  868 02/09/88   868 02/09/88   1/42  Tissue Mass Neck  6-10 Mm

  REMOVED  **  CID  5351 **   REASON - Moribund
                                897 03/09/88         Tissue Mass Body (Trunk) 21-25 Mm

537         537  805 12/08/87   835 01/07/88   2/41  Ruffled Fur
                 805 12/08/87   835 01/07/88   2/41  Tachypnea
                 805 12/08/87   835 01/07/88   2/41  Swelling Body Ventral
                 835 01/07/88   835 01/07/88   1/41  Emaciated

  REMOVED  **  CID  5371 **   REASON - Moribund
                                840 01/12/88         Abnormal Posture
                                840 01/12/88         Tachypnea
                                840 01/12/88         Hypoactivity

539         539  450 12/18/86   478 01/15/87   2/28  Emaciated

  REMOVED  **  CID  5391 **   REASON - Dead
                                483 01/20/87         Normal

540         540  140 02/11/86   616 06/02/87   6/42  Alopecia Body Ventral

  REMOVED  **  CID  5401 **   REASON - Moribund
                                884 02/25/88         Tachypnea
                                884 02/25/88         Comatose

541         541  534 03/12/87   616 06/02/87   4/39  Alopecia Body Ventral

  REMOVED  **  CID  5411 **   REASON - Dead
                                792 11/25/87         Normal

542         542  616 06/02/87   644 06/30/87   2/34  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID  5421 **   REASON - Dead
                                666 07/22/87         Normal

543         543  364 09/23/86   364 09/23/86   1/25  Tissue Mass Right Rear Leg 11-15 Mm

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 31
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
543         543  282 07/03/86   339 08/29/86   3/25  Tissue Mass Body (Trunk)  6-10 Mm
                 395 10/24/86   395 10/24/86   1/25  Tissue Mass Right Rear Leg 16-20 Mm
                 339 08/29/86   339 08/29/86   1/25  Override

  REMOVED  **  CID  5431 **   REASON - Moribund
                                398 10/27/86         Tissue Mass Right Rear Leg 11-15 Mm

545         545  672 07/28/87   672 07/28/87   1/35  Swelling Right Eye
                 672 07/28/87   672 07/28/87   1/35  Sore Right Ear Blue-Blk
                 616 06/02/87   672 07/28/87   3/35  Emaciated

  REMOVED  **  CID  5451 **   REASON - Dead
                                680 08/05/87         Swelling Right Ear
                                680 08/05/87         Emaciated
                                680 08/05/87         Discharge Right Ear

546         546  924 04/05/88   924 04/05/88   1/44  Head Tilted
                 924 04/05/88   924 04/05/88   1/44  Emaciated

  REMOVED  **  CID  5461 **   REASON - Dead
                                925 04/06/88         Normal

548         548  567 04/14/87   616 06/02/87   3/33  Emaciated

  REMOVED  **  CID  5481 **   REASON - Moribund
                                621 06/07/87         Emaciated

550         550  309 07/30/86   364 09/23/86   3/26  Alopecia Body Ventral
                 395 10/24/86   420 11/18/86   2/26  Alopecia Entire Animal

  REMOVED  **  CID  5501 **   REASON - Moribund
                                430 11/28/86         Alopecia Body Ventral
                                430 11/28/86         Swelling Body Ventral
                                430 11/28/86         Ruffled Fur

552         552 1008 06/28/88  1008 06/28/88   1/49  Tachypnea
                1008 06/28/88  1008 06/28/88   1/49  Emaciated
                1008 06/28/88  1008 06/28/88   1/49  Ruffled Fur

  REMOVED  **  CID  5521 **   REASON - Moribund
                               1010 06/30/88         Emaciated
                               1010 06/30/88         Abnormal Posture

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 32
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
552         552                1010 06/30/88         Hypoactivity

553         553  567 04/14/87   616 06/02/87   3/40  Alopecia Entire Animal
                 140 02/11/86   805 12/08/87  21/40  Alopecia Body Ventral

  REMOVED  **  CID  5531 **   REASON - Moribund
                                832 01/04/88         Dyspnea
                                832 01/04/88         Alopecia Body Ventral
                                832 01/04/88         Emaciated
                                832 01/04/88         Abnormal Posture

554         554  168 03/11/86   168 03/11/86   1/37  Alopecia Body Dorsal
                 196 04/08/86   616 06/02/87  16/37  Alopecia Entire Animal
                 140 02/11/86   140 02/11/86   1/37  Alopecia Body Ventral

  REMOVED  **  CID  5541 **   REASON - Moribund
                                733 09/27/87         Swelling Body Ventral
                                733 09/27/87         Ruffled Fur
                                733 09/27/87         Hypoactivity

555         555  897 03/09/88   897 03/09/88   1/44  Tissue Mass Right Front Leg  6-10 Mm
                 924 04/05/88   924 04/05/88   1/44  Tissue Mass Right Front Leg 11-15 Mm

  REMOVED  **  CID  5551 **   REASON - Dead
                                931 04/12/88         Tissue Mass Right Front Leg 26 or Gr

558         558  140 02/11/86   616 06/02/87   4/34  Alopecia Entire Animal
                 644 06/30/87   644 06/30/87   1/34  Swelling Left Eye
                 196 04/08/86   534 03/12/87  13/34  Alopecia Body Ventral
                 644 06/30/87   644 06/30/87   1/34  Head Tilted

  REMOVED  **  CID  5581 **   REASON - Dead
                                657 07/13/87         Head Tilted
                                657 07/13/87         Swelling Left Eye

560         560  339 08/29/86   616 06/02/87   5/50  Alopecia Body Ventral

  REMOVED  **  CID  5601 **   REASON - Dead
                               1023 07/13/88         Normal

562         562  868 02/09/88   868 02/09/88   1/42  Tissue Mass Neck 11-15 Mm

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 33
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
562         562  805 12/08/87   835 01/07/88   2/42  Tissue Mass Neck  6-10 Mm

  REMOVED  **  CID  5621 **   REASON - Moribund
                                869 02/10/88         Tissue Mass Neck 21-25 Mm

567         567  805 12/08/87   805 12/08/87   1/40  Head Tilted
                 805 12/08/87   805 12/08/87   1/40  Emaciated

  REMOVED  **  CID  5671 **   REASON - Dead
                                806 12/09/87         Normal

568         568  567 04/14/87   616 06/02/87   3/44  Alopecia Body Ventral

  REMOVED  **  CID  5681 **   REASON - Dead
                                946 04/27/88         Normal

571         571 1008 06/28/88  1008 06/28/88   1/49  Tachypnea
                1008 06/28/88  1008 06/28/88   1/49  Ruffled Fur
                1008 06/28/88  1008 06/28/88   1/49  Emaciated

  REMOVED  **  CID  5711 **   REASON - Dead
                               1010 06/30/88         Normal

573         573  897 03/09/88   924 04/05/88   2/44  Tissue Mass Right Rear Leg  6-10 Mm
                 835 01/07/88   868 02/09/88   2/44  Tissue Mass Head  6-10 Mm
                 897 03/09/88   924 04/05/88   2/44  Tissue Mass Head 11-15 Mm
                 756 10/20/87   805 12/08/87   3/44  Tissue Mass Head  3- 5 Mm
                 140 02/11/86   616 06/02/87  18/44  Alopecia Entire Animal

  REMOVED  **  CID  5731 **   REASON - Moribund
                                939 04/20/88         Tissue Mass Neck 16-20 Mm
                                939 04/20/88         Comatose

574         574  567 04/14/87   616 06/02/87   3/43  Alopecia Body Ventral
                 868 02/09/88   897 03/09/88   2/43  Tissue Mass Shoulder  6-10 Mm

  REMOVED  **  CID  5741 **   REASON - Moribund
                                904 03/16/88         Tremors
                                904 03/16/88         Tissue Mass Body (Trunk) 21-25 Mm
                                904 03/16/88         Abnormal Posture
                                904 03/16/88         Tachypnea
                                904 03/16/88         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 34
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

576         576  980 05/31/88   980 05/31/88   1/47  Swelling Body Ventral

  REMOVED  **  CID  5761 **   REASON - Moribund
                                984 06/04/88         Tachypnea
                                984 06/04/88         Comatose

577         577  756 10/20/87   868 02/09/88   5/42  Alopecia Entire Animal
                 567 04/14/87   728 09/22/87   7/42  Alopecia Body Ventral

  REMOVED  **  CID  5771 **   REASON - Dead
                                882 02/23/88         Normal

584         584  700 08/25/87   785 11/18/87   4/39  Sore Left Ear Red

  REMOVED  **  CID  5841 **   REASON - Moribund
                                788 11/21/87         Tissue Mass Neck  6-10 Mm
                                788 11/21/87         Swelling Body Ventral

585         585  168 03/11/86   728 09/22/87  18/37  Alopecia Body Ventral
                 567 04/14/87   616 06/02/87   3/37  Alopecia Entire Animal

  REMOVED  **  CID  5851 **   REASON - Dead
                                729 09/23/87         Normal

586         586  478 01/15/87   805 12/08/87  11/40  Alopecia Entire Animal
                 805 12/08/87   805 12/08/87   1/40  Emaciated
                 506 02/12/87   644 06/30/87   2/40  Alopecia Body Ventral

  REMOVED  **  CID  5861 **   REASON - Dead
                                807 12/10/87         Normal

587         587  644 06/30/87   644 06/30/87   1/34  Emaciated
                 478 01/15/87   478 01/15/87   1/34  Alopecia Body Ventral

  REMOVED  **  CID  5871 **   REASON - Moribund
                                661 07/17/87         Hypoactivity
                                661 07/17/87         Prostration

589         589  805 12/08/87   805 12/08/87   1/40  Sore Body Dorsal  6-10 Mm
                 785 11/18/87   785 11/18/87   1/40  Sore Body Dorsal  3- 5 Mm

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 35
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

  REMOVED  **  CID  5891 **   REASON - Moribund
589         589                 815 12/18/87         Tissue Mass Body (Trunk) 21-25 Mm
                                815 12/18/87         Emaciated
                                815 12/18/87         Abnormal Posture
                                815 12/18/87         Tachypnea
                                815 12/18/87         Hypoactivity

591         591 1022 07/12/88  1022 07/12/88   1/50  Tissue Mass Neck  6-10 Mm

  REMOVED  **  CID  5911 **   REASON - Term-Sac
                               1030 07/20/88         Tissue Mass Neck 11-15 Mm

592         592  616 06/02/87   616 06/02/87   1/43  Alopecia Entire Animal
                 567 04/14/87   595 05/12/87   2/43  Alopecia Left Rear Foot
                 567 04/14/87   595 05/12/87   2/43  Alopecia Right Rear Leg
                 450 12/18/86   450 12/18/86   1/43  Alopecia Left Front Leg
                 478 01/15/87   534 03/12/87   3/43  Alopecia Left Rear Leg

  REMOVED  **  CID  5921 **   REASON - Dead
                                899 03/11/88         Normal

593         593  339 08/29/86   616 06/02/87  11/37  Alopecia Body Ventral

  REMOVED  **  CID  5931 **   REASON - Moribund
                                745 10/09/87         Dyspnea
                                745 10/09/87         Swelling Body Ventral
                                745 10/09/87         Hypoactivity

594         594  168 03/11/86   616 06/02/87  17/50  Alopecia Entire Animal
                1022 07/12/88  1022 07/12/88   1/50  Emaciated

  REMOVED  **  CID  5941 **   REASON - Dead
                               1027 07/17/88         Emaciated

596         596  595 05/12/87   616 06/02/87   2/45  Alopecia Body Ventral

  REMOVED  **  CID  5961 **   REASON - Dead
                                957 05/08/88         Normal

598         598  478 01/15/87   595 05/12/87   5/44  Alopecia Body Ventral

  REMOVED  **  CID  5981 **   REASON - Dead

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 36
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 2                      ROOM/AREA:   5502         FIRST DOSE: 09/25/85
            SEX: FEMALE                               TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
598         598                 943 04/24/88         Alopecia Body Ventral

599         599  339 08/29/86   616 06/02/87   5/41  Alopecia Entire Animal
                 168 03/11/86   835 01/07/88  18/41  Alopecia Body Ventral
                 140 02/11/86   140 02/11/86   1/41  Alopecia Anal Area
                 835 01/07/88   835 01/07/88   1/41  Tissue Mass Right Front Foot  6-10 Mm

  REMOVED  **  CID  5991 **   REASON - Moribund
                                853 01/25/88         Tissue Mass Body Ventral 16-20 Mm
                                853 01/25/88         Tissue Mass Groin 11-15 Mm
                                853 01/25/88         Ataxia
                                853 01/25/88         Abnormal Posture
                                853 01/25/88         Tachypnea

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 37
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

3             3  168 03/10/86   868 02/08/88  25/42  Alopecia Body Ventral

  REMOVED  **  CID    31 **   REASON - Moribund
                                877 02/17/88         Abnormal Posture
                                877 02/17/88         Tachypnea
                                877 02/17/88         Hypoactivity

5             5  309 07/29/86   364 09/22/86   3/42  Alopecia Body Ventral
                 395 10/23/86   868 02/08/88  18/42  Alopecia Entire Animal

  REMOVED  **  CID    51 **   REASON - Moribund
                                878 02/18/88         Abnormal Posture
                                878 02/18/88         Tachypnea
                                878 02/18/88         Hypoactivity

6             6  728 09/21/87   728 09/21/87   1/42  Tissue Mass Groin  0- 2 Mm
                 868 02/08/88   868 02/08/88   1/42  Tachypnea

  REMOVED  **  CID    61 **   REASON - Moribund
                                871 02/11/88         Tachypnea
                                871 02/11/88         Comatose

7             7  966 05/16/88   966 05/16/88   1/49  Swelling Body Ventral
                1009 06/28/88  1009 06/28/88   1/49  Tachypnea
                1009 06/28/88  1009 06/28/88   1/49  Ruffled Fur
                1009 06/28/88  1009 06/28/88   1/49  Emaciated

  REMOVED  **  CID    71 **   REASON - Dead
                               1013 07/02/88         Emaciated

8             8 1094 09/21/88  1094 09/21/88   1/55  Tachypnea
                1094 09/21/88  1094 09/21/88   1/55  Ruffled Fur
                1065 08/23/88  1094 09/21/88   3/55  Swelling Body Ventral

  REMOVED  **  CID    81 **   REASON - Dead
                               1099 09/26/88         Swelling Body Ventral

9             9 1122 10/19/88  1122 10/19/88   1/57  Prolapse Penis
                1065 08/23/88  1122 10/19/88   5/57  Tachypnea
                1065 08/23/88  1122 10/19/88   5/57  Ruffled Fur
                 728 09/21/87   728 09/21/87   1/57  Tissue Mass Groin  0- 2 Mm

  REMOVED  **  CID    91 **   REASON - Term-Sac

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 38
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
9             9                1134 10/31/88         Prolapse Penis
                               1134 10/31/88         Ruffled Fur
                               1134 10/31/88         Tachypnea

10           10  616 06/01/87   616 06/01/87   1/44  Emaciated

  REMOVED  **  CID   101 **   REASON - Dead
                                929 04/09/88         Normal

13           13 1023 07/12/88  1050 08/08/88   3/52  Swelling Body Ventral

  REMOVED  **  CID   131 **   REASON - Dead
                               1053 08/11/88         Normal

14           14 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                1108 10/05/88  1122 10/19/88   2/57  Tachypnea
                1023 07/12/88  1122 10/19/88   8/57  Swelling Body Ventral

  REMOVED  **  CID   141 **   REASON - Term-Sac
                               1134 10/31/88         Normal

15           15  700 08/24/87   700 08/24/87   1/36  Sore Penis Yellow
                 700 08/24/87   700 08/24/87   1/36  Prostration

  REMOVED  **  CID   151 **   REASON - Dead
                                712 09/05/87         Tissue Mass Penis  6-10 Mm

17           17 1065 08/23/88  1108 10/05/88   4/56  Ruffled Fur
                 981 05/31/88   981 05/31/88   1/56  Emaciated
                1009 06/28/88  1108 10/05/88   8/56  Tissue Mass Left Eye 11-15 Mm
                1094 09/21/88  1094 09/21/88   1/56  Abnormal Posture
                 506 02/11/87   995 06/14/88  14/56  Swelling Left Eye
                 616 06/01/87   995 06/14/88   8/56  Discharge Left Eye
                1079 09/06/88  1108 10/05/88   2/56  Tachypnea
                 756 10/19/87   897 03/08/88   6/56  Tissue Mass Left Eye  6-10 Mm

  REMOVED  **  CID   171 **   REASON - Dead
                               1117 10/14/88         Tissue Mass Left Eye 11-15 Mm

18           18  785 11/17/87   805 12/07/87   2/44  Tissue Mass Neck  6-10 Mm
                 835 01/06/88   924 04/04/88   4/44  Tissue Mass Neck 11-15 Mm

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 39
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

  REMOVED  **  CID   181 **   REASON - Dead
18           18                 945 04/25/88         Tissue Mass Neck 21-25 Mm

19           19  785 11/17/87   785 11/17/87   1/39  Tissue Mass Body Ventral 16-20 Mm

  REMOVED  **  CID   191 **   REASON - Dead
                                785 11/17/87         Normal

21           21  672 07/27/87   672 07/27/87   1/40  Alopecia Neck
                 450 12/17/86   805 12/07/87   8/40  Alopecia Body Ventral

  REMOVED  **  CID   211 **   REASON - Moribund
                                817 12/19/87         Dyspnea
                                817 12/19/87         Abnormal Posture
                                817 12/19/87         Hypoactivity

24           24  897 03/08/88   924 04/04/88   2/44  Swelling Right Eye
                 569 04/15/87   924 04/04/88  14/44  Alopecia Body Ventral

  REMOVED  **  CID   241 **   REASON - Moribund
                                932 04/12/88         Swelling Toes
                                932 04/12/88         Tachypnea
                                932 04/12/88         Comatose

25           25 1065 08/23/88  1094 09/21/88   3/55  Ruffled Fur
                 981 05/31/88   995 06/14/88   2/55  Tachypnea

  REMOVED  **  CID   251 **   REASON - Dead
                               1100 09/27/88         Normal

26           26  728 09/21/87   728 09/21/87   1/37  Tissue Mass Groin  3- 5 Mm
                 700 08/24/87   728 09/21/87   2/37  Emaciated

  REMOVED  **  CID   261 **   REASON - Moribund
                                732 09/25/87         Emaciated
                                732 09/25/87         Tachypnea
                                732 09/25/87         Limb Paralysis Right Rear Leg
                                732 09/25/87         Limb Paralysis Left Rear Leg

27           27 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                1108 10/05/88  1122 10/19/88   2/57  Sore Body Dorsal  6-10 Mm

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 40
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
27           27 1122 10/19/88  1122 10/19/88   1/57  Prolapse Penis
                1122 10/19/88  1122 10/19/88   1/57  Polyuria
                1108 10/05/88  1122 10/19/88   2/57  Tachypnea

  REMOVED  **  CID   271 **   REASON - Term-Sac
                               1134 10/31/88         Alopecia Body Dorsal
                               1134 10/31/88         Prolapse Penis
                               1134 10/31/88         Ruffled Fur
                               1134 10/31/88         Tachypnea
                               1134 10/31/88         Polyuria

28           28  616 06/01/87   644 06/29/87   2/40  Alopecia Body Ventral

  REMOVED  **  CID   281 **   REASON - Dead
                                826 12/28/87         Normal

30           30  478 01/14/87   506 02/11/87   2/29  Emaciated

  REMOVED  **  CID   301 **   REASON - Moribund
                                528 03/05/87         Tremors
                                528 03/05/87         Hypoactivity

32           32  478 01/14/87   478 01/14/87   1/38  Emaciated

  REMOVED  **  CID   321 **   REASON - Dead
                                772 11/04/87         Normal

33           33  835 01/06/88   835 01/06/88   1/43  Circling
                 168 03/10/86   168 03/10/86   1/43  Alopecia Body Ventral

  REMOVED  **  CID   331 **   REASON - Dead
                                911 03/22/88         Normal

35           35  569 04/15/87   569 04/15/87   1/31  Emaciated
                 569 04/15/87   569 04/15/87   1/31  Ruffled Fur

  REMOVED  **  CID   351 **   REASON - Moribund
                                586 05/02/87         Abnormal Posture
                                586 05/02/87         Ruffled Fur
                                586 05/02/87         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 41
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

38           38  616 06/01/87   616 06/01/87   1/36  Tissue Mass Body (Trunk)  0- 2 Mm
                 569 04/15/87   700 08/24/87   3/36  Emaciated

  REMOVED  **  CID   381 **   REASON - Moribund
                                727 09/20/87         Emaciated
                                727 09/20/87         Abnormal Posture
                                727 09/20/87         Ruffled Fur

39           39  835 01/06/88   835 01/06/88   1/41  Emaciated
                 756 10/19/87   785 11/17/87   2/41  Tissue Mass Body Ventral 11-15 Mm
                 805 12/07/87   835 01/06/88   2/41  Swelling Body Ventral

  REMOVED  **  CID   391 **   REASON - Moribund
                                861 02/01/88         Swelling Body Ventral
                                861 02/01/88         Hypoactivity

40           40  309 07/29/86   616 06/01/87   9/39  Alopecia Body Ventral
                 672 07/27/87   785 11/17/87   5/39  Alopecia Neck

  REMOVED  **  CID   401 **   REASON - Dead
                                793 11/25/87         Normal

42           42 1065 08/23/88  1108 10/05/88   4/56  Ruffled Fur
                1065 08/23/88  1108 10/05/88   4/56  Tachypnea
                1038 07/27/88  1108 10/05/88   6/56  Emaciated
                1065 08/23/88  1108 10/05/88   4/56  Abnormal Posture

  REMOVED  **  CID   421 **   REASON - Moribund
                               1117 10/14/88         Dyspnea
                               1117 10/14/88         Emaciated
                               1117 10/14/88         Abnormal Posture
                               1117 10/14/88         Ruffled Fur
                               1117 10/14/88         Hypoactivity

43           43 1023 07/12/88  1065 08/23/88   4/53  Tachypnea
                1009 06/28/88  1065 08/23/88   5/53  Swelling Right Eye

  REMOVED  **  CID   431 **   REASON - Moribund
                               1076 09/03/88         Tissue Mass Right Eye  3- 5 Mm
                               1076 09/03/88         Emaciated
                               1076 09/03/88         Abnormal Posture
                               1076 09/03/88         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 42
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

44           44  450 12/17/86   506 02/11/87   3/57  Malocclusion
                 805 12/07/87  1122 10/19/88  18/57  Tachypnea
                 805 12/07/87  1122 10/19/88  16/57  Ruffled Fur
                 140 02/10/86   140 02/10/86   1/57  Alopecia Left Front Leg
                 196 04/07/86  1122 10/19/88  39/57  Alopecia Body Ventral
                 224 05/05/86   224 05/05/86   1/57  Alopecia Mammary
                 339 08/28/86   616 06/01/87   4/57  Emaciated

  REMOVED  **  CID   441 **   REASON - Dead
                               1134 10/31/88         Alopecia Body Ventral
                               1134 10/31/88         Ruffled Fur

48           48  616 06/01/87   700 08/24/87   4/36  Tissue Mass Body Ventral  0- 2 Mm
                 595 05/11/87   595 05/11/87   1/36  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID   481 **   REASON - Dead
                                717 09/10/87         Normal

49           49  981 05/31/88   995 06/14/88   2/49  Emaciated
                 966 05/16/88   995 06/14/88   3/49  Tachypnea
                 728 09/21/87   728 09/21/87   1/49  Tissue Mass Groin  3- 5 Mm
                 966 05/16/88   995 06/14/88   3/49  Ruffled Fur
                1009 06/28/88  1009 06/28/88   1/49  Prolapse Penis

  REMOVED  **  CID   491 **   REASON - Moribund
                               1018 07/07/88         Tremors
                               1018 07/07/88         Emaciated
                               1018 07/07/88         Abnormal Posture
                               1018 07/07/88         Prolapse Penis
                               1018 07/07/88         Tachypnea

50           50 1050 08/08/88  1050 08/08/88   1/52  Swelling Body Ventral

  REMOVED  **  CID   501 **   REASON - Moribund
                               1052 08/10/88         Comatose

52           52  506 02/11/87   616 06/01/87   3/38  Emaciated

  REMOVED  **  CID   521 **   REASON - Dead
                                771 11/03/87         Normal

53           53  981 05/31/88   981 05/31/88   1/47  Swelling Body Ventral
                 966 05/16/88   981 05/31/88   2/47  Ruffled Fur

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 43
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
53           53  756 10/19/87   981 05/31/88  10/47  Tissue Mass Groin  3- 5 Mm
                 966 05/16/88   981 05/31/88   2/47  Tachypnea

  REMOVED  **  CID   531 **   REASON - Moribund
                                994 06/13/88         Dyspnea
                                994 06/13/88         Abnormal Posture
                                994 06/13/88         Jaundice
                                994 06/13/88         Ruffled Fur

54           54 1038 07/27/88  1038 07/27/88   1/50  Convulsion/Seizure

  REMOVED  **  CID   541 **   REASON - Moribund
                               1038 07/27/88         Emaciated
                               1038 07/27/88         Abnormal Posture
                               1038 07/27/88         Ruffled Fur

55           55  616 06/01/87   616 06/01/87   1/33  Emaciated

  REMOVED  **  CID   551 **   REASON - Dead
                                637 06/22/87         Normal

56           56  835 01/06/88  1079 09/06/88  14/54  Alopecia Neck

  REMOVED  **  CID   561 **   REASON - Moribund
                               1087 09/14/88         Comatose

57           57  450 12/17/86   981 05/31/88  21/47  Alopecia Body Ventral

  REMOVED  **  CID   571 **   REASON - Dead
                                994 06/13/88         Alopecia Body Ventral

58           58  595 05/11/87   595 05/11/87   1/43  Emaciated
                 595 05/11/87   700 08/24/87   5/43  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID   581 **   REASON - Moribund
                                911 03/22/88         Tissue Mass Tail  6-10 Mm
                                911 03/22/88         Comatose

59           59  897 03/08/88   897 03/08/88   1/47  Tissue Mass Right Eye  3- 5 Mm
                 981 05/31/88   981 05/31/88   1/47  Tachypnea
                 835 01/06/88   868 02/08/88   2/47  Swelling Right Eye

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 44
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
59           59  835 01/06/88   981 05/31/88   6/47  Discharge Right Eye
                 924 04/04/88   981 05/31/88   4/47  Tissue Mass Right Eye 11-15 Mm

  REMOVED  **  CID   591 **   REASON - Moribund
                                985 06/04/88         Tissue Mass Right Eye 11-15 Mm
                                985 06/04/88         Emaciated
                                985 06/04/88         Abnormal Posture
                                985 06/04/88         Hypoactivity

60           60  533 03/10/87   700 08/24/87   7/40  Alopecia Body Ventral

  REMOVED  **  CID   601 **   REASON - Dead
                                823 12/25/87         Normal

61           61  981 05/31/88  1023 07/12/88   3/50  Tachypnea
                 966 05/16/88  1023 07/12/88   4/50  Swelling Body Ventral
                1023 07/12/88  1023 07/12/88   1/50  Polyuria
                1023 07/12/88  1023 07/12/88   1/50  Abnormal Posture
                 981 05/31/88  1023 07/12/88   3/50  Ruffled Fur

  REMOVED  **  CID   611 **   REASON - Dead
                               1024 07/13/88         Normal

62           62 1009 06/28/88  1122 10/19/88   9/57  Ruffled Fur
                 450 12/17/86  1122 10/19/88  30/57  Alopecia Body Ventral
                 981 05/31/88  1122 10/19/88  11/57  Tachypnea

  REMOVED  **  CID   621 **   REASON - Term-Sac
                               1134 10/31/88         Alopecia Body Ventral
                               1134 10/31/88         Ruffled Fur
                               1134 10/31/88         Tachypnea

63           63  868 02/08/88   868 02/08/88   1/42  Sore Body Dorsal  3- 5 Mm

  REMOVED  **  CID   631 **   REASON - Moribund
                                886 02/26/88         Abnormal Posture
                                886 02/26/88         Tachypnea
                                886 02/26/88         Hypoactivity

66           66  785 11/17/87   897 03/08/88   5/43  Alopecia Neck
                 168 03/10/86   168 03/10/86   1/43  Alopecia Body Ventral

  REMOVED  **  CID   661 **   REASON - Dead

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 45
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
66           66                 906 03/17/88         Normal

67           67  140 02/10/86   140 02/10/86   1/46  Alopecia Right Front Foot
                 168 03/10/86   966 05/16/88  21/46  Alopecia Body Ventral
                 309 07/29/86   478 01/14/87   6/46  Alopecia Neck

  REMOVED  **  CID   671 **   REASON - Dead
                                981 05/31/88         Alopecia Body Ventral

68           68  168 03/10/86   756 10/19/87  21/38  Alopecia Body Ventral

  REMOVED  **  CID   681 **   REASON - Moribund
                                770 11/02/87         Dyspnea
                                770 11/02/87         Alopecia Body Ventral
                                770 11/02/87         Emaciated
                                770 11/02/87         Hypothermia
                                770 11/02/87         Ruffled Fur
                                770 11/02/87         Prostration

70           70  785 11/17/87   785 11/17/87   1/39  Tissue Mass Tail  0- 2 Mm
                 756 10/19/87   785 11/17/87   2/39  Sore Body Dorsal  3- 5 Mm

  REMOVED  **  CID   701 **   REASON - Dead
                                796 11/28/87         Normal

71           71 1009 06/28/88  1122 10/19/88   9/57  Swelling Body Ventral
                1108 10/05/88  1122 10/19/88   2/57  Tachypnea

  REMOVED  **  CID   711 **   REASON - Term-Sac
                               1134 10/31/88         Swelling Body Ventral
                               1134 10/31/88         Tachypnea

73           73  728 09/21/87   728 09/21/87   1/57  Rales
                 756 10/19/87   785 11/17/87   2/57  Tissue Mass Body Ventral  3- 5 Mm

  REMOVED  **  CID   731 **   REASON - Term-Sac
                               1134 10/31/88         Normal

74           74  966 05/16/88   966 05/16/88   1/57  Swelling Right Eye
                1023 07/12/88  1122 10/19/88   8/57  Ruffled Fur
                1122 10/19/88  1122 10/19/88   1/57  Polyuria

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 46
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
74           74 1023 07/12/88  1122 10/19/88   8/57  Tachypnea

  REMOVED  **  CID   741 **   REASON - Term-Sac
                               1134 10/31/88         Ruffled Fur
                               1134 10/31/88         Tachypnea
                               1134 10/31/88         Polyuria

75           75  805 12/07/87   805 12/07/87   1/40  Ruffled Fur
                 533 03/10/87   700 08/24/87   7/40  Alopecia Body Ventral
                 805 12/07/87   805 12/07/87   1/40  Prolapse Penis
                 805 12/07/87   805 12/07/87   1/40  Emaciated
                 595 05/11/87   595 05/11/87   1/40  Swelling Groin

  REMOVED  **  CID   751 **   REASON - Moribund
                                809 12/11/87         Ruffled Fur
                                809 12/11/87         Tachypnea
                                809 12/11/87         Hypoactivity

76           76  981 05/31/88   981 05/31/88   1/48  Swelling Body Ventral

  REMOVED  **  CID   761 **   REASON - Moribund
                               1001 06/20/88         Dyspnea
                               1001 06/20/88         Abnormal Posture
                               1001 06/20/88         Ruffled Fur

77           77  897 03/08/88   897 03/08/88   1/43  Swelling Body Ventral
                 728 09/21/87   728 09/21/87   1/43  Tissue Mass Groin  3- 5 Mm

  REMOVED  **  CID   771 **   REASON - Dead
                                911 03/22/88         Normal

79           79  835 01/06/88   868 02/08/88   2/42  Tachypnea

  REMOVED  **  CID   791 **   REASON - Moribund
                                890 03/01/88         Tremors
                                890 03/01/88         Abnormal Posture
                                890 03/01/88         Tachypnea

80           80 1108 10/05/88  1122 10/19/88   2/57  Emaciated
                1122 10/19/88  1122 10/19/88   1/57  Urine Stain
                1094 09/21/88  1122 10/19/88   3/57  Abnormal Posture
                1023 07/12/88  1122 10/19/88   8/57  Ruffled Fur

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 47
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
80           80 1023 07/12/88  1122 10/19/88   8/57  Tachypnea

  REMOVED  **  CID   801 **   REASON - Moribund
                               1125 10/22/88         Emaciated
                               1125 10/22/88         Abnormal Posture
                               1125 10/22/88         Prolapse Penis
                               1125 10/22/88         Tachypnea
                               1125 10/22/88         Comatose

81           81 1009 06/28/88  1122 10/19/88   9/57  Tachypnea
                 868 02/08/88   868 02/08/88   1/57  Sore Right Ear  0- 2 Mm
                 756 10/19/87   995 06/14/88  11/57  Tissue Mass Groin  0- 2 Mm
                1108 10/05/88  1122 10/19/88   2/57  Tissue Mass Right Ear  6-10 Mm
                 924 04/04/88  1094 09/21/88  12/57  Tissue Mass Right Ear  3- 5 Mm

  REMOVED  **  CID   811 **   REASON - Term-Sac
                               1134 10/31/88         Tissue Mass Right Ear  3- 5 Mm
                               1134 10/31/88         Tachypnea

82           82 1038 07/27/88  1122 10/19/88   7/57  Ruffled Fur
                1108 10/05/88  1122 10/19/88   2/57  Tachypnea

  REMOVED  **  CID   821 **   REASON - Term-Sac
                               1134 10/31/88         Ruffled Fur
                               1134 10/31/88         Tachypnea

83           83 1038 07/27/88  1050 08/08/88   2/52  Tachypnea
                1050 08/08/88  1050 08/08/88   1/52  Emaciated
                1038 07/27/88  1050 08/08/88   2/52  Ruffled Fur

  REMOVED  **  CID   831 **   REASON - Dead
                               1058 08/16/88         Emaciated

84           84  966 05/16/88   966 05/16/88   1/46  Ruffled Fur
                 966 05/16/88   966 05/16/88   1/46  Tachypnea

  REMOVED  **  CID   841 **   REASON - Dead
                                967 05/17/88         Normal

85           85  168 03/10/86   168 03/10/86   1/37  Alopecia Body Ventral

  REMOVED  **  CID   851 **   REASON - Moribund

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 48
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
85           85                 754 10/17/87         Abnormal Posture
                                754 10/17/87         Hypoactivity

86           86  168 03/10/86   168 03/10/86   1/41  Alopecia Body Ventral

  REMOVED  **  CID   861 **   REASON - Moribund
                                863 02/03/88         Abnormal Posture
                                863 02/03/88         Tachypnea
                                863 02/03/88         Hypoactivity

87           87  450 12/17/86  1108 10/05/88  10/56  Alopecia Body Ventral
                 644 06/29/87   981 05/31/88  14/56  Alopecia Neck
                1038 07/27/88  1108 10/05/88   6/56  Ruffled Fur
                 756 10/19/87   835 01/06/88   4/56  Tissue Mass Groin  3- 5 Mm

  REMOVED  **  CID   871 **   REASON - Dead
                               1111 10/08/88         Normal

88           88  756 10/19/87   756 10/19/87   1/38  Emaciated

  REMOVED  **  CID   881 **   REASON - Moribund
                                757 10/20/87         Abnormal Posture
                                757 10/20/87         Tachypnea

89           89  168 03/10/86   168 03/10/86   1/41  Alopecia Body Ventral

  REMOVED  **  CID   891 **   REASON - Dead
                                862 02/02/88         Normal

90           90  700 08/24/87   700 08/24/87   1/36  Tissue Mass Right Rear Leg 16-20 Mm

  REMOVED  **  CID   901 **   REASON - Moribund
                                706 08/30/87         Tissue Mass Groin 16-20 Mm
                                706 08/30/87         Abnormal Posture
                                706 08/30/87         Ruffled Fur

92           92  450 12/17/86   450 12/17/86   1/27  Limb Paralysis Left Rear Leg
                 450 12/17/86   450 12/17/86   1/27  Limb Paralysis Right Rear Leg

  REMOVED  **  CID   921 **   REASON - Accident
                                451 12/18/86         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 49
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
92           92                 451 12/18/86         Limb Paralysis Right Rear Leg
                                451 12/18/86         Limb Paralysis Left Rear Leg

94           94  952 05/02/88  1009 06/28/88   5/49  Swelling Body Ventral
                 966 05/16/88   966 05/16/88   1/49  Diarrhea
                 966 05/16/88  1009 06/28/88   2/49  Ruffled Fur
                1009 06/28/88  1009 06/28/88   1/49  Polyuria
                 966 05/16/88  1009 06/28/88   2/49  Tachypnea

  REMOVED  **  CID   941 **   REASON - Dead
                               1012 07/01/88         Normal

95           95  835 01/06/88   835 01/06/88   1/41  Swelling Left Eye
                 835 01/06/88   835 01/06/88   1/41  Discharge Left Eye

  REMOVED  **  CID   951 **   REASON - Moribund
                                862 02/02/88         Head Tilted
                                862 02/02/88         Swelling Left Eye
                                862 02/02/88         Ruffled Fur
                                862 02/02/88         Tachypnea
                                862 02/02/88         Hypoactivity

96           96  868 02/08/88   897 03/08/88   2/43  Sore Body Dorsal  3- 5 Mm
                 785 11/17/87   897 03/08/88   5/43  Discharge Right Eye
                 700 08/24/87   897 03/08/88   8/43  Swelling Right Eye

  REMOVED  **  CID   961 **   REASON - Moribund
                                918 03/29/88         Tissue Mass Body (Trunk) 21-25 Mm
                                918 03/29/88         Tissue Mass Right Eye  3- 5 Mm
                                918 03/29/88         Hyperactive
                                918 03/29/88         Abnormal Posture
                                918 03/29/88         Ruffled Fur
                                918 03/29/88         Tachypnea

97           97  981 05/31/88   995 06/14/88   2/48  Emaciated

  REMOVED  **  CID   971 **   REASON - Dead
                               1003 06/22/88         Normal

98           98  952 05/02/88  1023 07/12/88   6/50  Tissue Mass Neck  6-10 Mm

  REMOVED  **  CID   981 **   REASON - Dead

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 50
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
98           98                1029 07/18/88         Normal

99           99  868 02/08/88   868 02/08/88   1/42  Emaciated
                 868 02/08/88   868 02/08/88   1/42  Prostration

  REMOVED  **  CID   991 **   REASON - Moribund
                                868 02/08/88         Ataxia
                                868 02/08/88         Abnormal Posture
                                868 02/08/88         Hypoactivity

101         101  616 06/01/87   700 08/24/87   4/38  Tissue Mass Body (Trunk)  3- 5 Mm
                 728 09/21/87   756 10/19/87   2/38  Tissue Mass Tail  3- 5 Mm

  REMOVED  **  CID  1011 **   REASON - Dead
                                762 10/25/87         Tissue Mass Tail  6-10 Mm

103         103  924 04/04/88   995 06/14/88   5/48  Tachypnea
                 924 04/04/88   995 06/14/88   5/48  Ruffled Fur
                 924 04/04/88   924 04/04/88   1/48  Emaciated

  REMOVED  **  CID  1031 **   REASON - Dead
                                998 06/17/88         Normal

104         104  140 02/10/86   140 02/10/86   1/26  Alopecia Left Rear Leg

  REMOVED  **  CID  1041 **   REASON - Dead
                                427 11/24/86         Normal

105         105 1108 10/05/88  1122 10/19/88   2/57  Tachypnea
                1079 09/06/88  1122 10/19/88   3/57  Ruffled Fur

  REMOVED  **  CID  1051 **   REASON - Term-Sac
                               1134 10/31/88         Ruffled Fur
                               1134 10/31/88         Tachypnea

106         106  616 06/01/87   616 06/01/87   1/44  Tissue Mass Body (Trunk)  0- 2 Mm
                 450 12/17/86   478 01/14/87   2/44  Alopecia Face
                 421 11/18/86   616 06/01/87   7/44  Alopecia Body Ventral

  REMOVED  **  CID  1061 **   REASON - Moribund
                                938 04/18/88         Tremors

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 51
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
106         106                 938 04/18/88         Emaciated
                                938 04/18/88         Tachypnea

107         107  700 08/24/87   756 10/19/87   3/38  Emaciated

  REMOVED  **  CID  1071 **   REASON - Moribund
                                759 10/22/87         Emaciated
                                759 10/22/87         Hypothermia
                                759 10/22/87         Ruffled Fur

109         109  835 01/06/88   835 01/06/88   1/41  Tachypnea
                 835 01/06/88   835 01/06/88   1/41  Ruffled Fur
                 364 09/22/86   616 06/01/87  10/41  Alopecia Body Ventral
                 835 01/06/88   835 01/06/88   1/41  Emaciated

  REMOVED  **  CID  1091 **   REASON - Moribund
                                841 01/12/88         Abnormal Posture
                                841 01/12/88         Tachypnea
                                841 01/12/88         Hypoactivity

110         110  756 10/19/87   805 12/07/87   3/55  Tissue Mass Groin  3- 5 Mm

  REMOVED  **  CID  1101 **   REASON - Moribund
                               1106 10/03/88         Prolapse Penis
                               1106 10/03/88         Urine Stain
                               1106 10/03/88         Tachypnea
                               1106 10/03/88         Comatose

111         111  168 03/10/86   168 03/10/86   1/43  Alopecia Body Ventral
                 644 06/29/87   672 07/27/87   2/43  Tissue Mass Body (Trunk)  6-10 Mm
                 805 12/07/87   805 12/07/87   1/43  Tissue Mass Groin  3- 5 Mm

  REMOVED  **  CID  1111 **   REASON - Moribund
                                922 04/02/88         Abnormal Posture
                                922 04/02/88         Tachypnea
                                922 04/02/88         Comatose

112         112  533 03/10/87   533 03/10/87   1/30  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID  1121 **   REASON - Dead
                                534 03/11/87         Normal

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 52
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

113         113 1050 08/08/88  1050 08/08/88   1/52  Micro-ophthalmia

  REMOVED  **  CID  1131 **   REASON - Moribund
                               1064 08/22/88         Comatose

114         114 1050 08/08/88  1122 10/19/88   3/57  Tachypnea
                1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                1122 10/19/88  1122 10/19/88   1/57  Prolapse Penis
                1079 09/06/88  1122 10/19/88   3/57  Swelling Body Ventral
                 785 11/17/87   785 11/17/87   1/57  Tissue Mass Groin  3- 5 Mm

  REMOVED  **  CID  1141 **   REASON - Term-Sac
                               1134 10/31/88         Swelling Body Ventral
                               1134 10/31/88         Prolapse Penis
                               1134 10/31/88         Ruffled Fur
                               1134 10/31/88         Tachypnea

115         115  897 03/08/88   897 03/08/88   1/43  Swelling Body Ventral

  REMOVED  **  CID  1151 **   REASON - Dead
                                919 03/30/88         Normal

118         118  924 04/04/88   924 04/04/88   1/44  Sore Skin  6-10 Mm
                 785 11/17/87   924 04/04/88   6/44  Swelling Left Eye

  REMOVED  **  CID  1181 **   REASON - Moribund
                                928 04/08/88         Emaciated
                                928 04/08/88         Hyperactive
                                928 04/08/88         Abnormal Posture
                                928 04/08/88         Wound Body (Trunk) 16-20 Mm
                                928 04/08/88         Tachypnea

119         119  981 05/31/88   981 05/31/88   1/47  Tachypnea
                 966 05/16/88   966 05/16/88   1/47  Tissue Mass Right Rear Leg 11-15 Mm
                 952 05/02/88   952 05/02/88   1/47  Tissue Mass Left Rear Leg  6-10 Mm
                 981 05/31/88   981 05/31/88   1/47  Tissue Mass Left Rear Leg 11-15 Mm
                 981 05/31/88   981 05/31/88   1/47  Ruffled Fur

  REMOVED  **  CID  1191 **   REASON - Dead
                                982 06/01/88         Tissue Mass Left Rear Leg  6-10 Mm

121         121 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                 595 05/11/87   616 06/01/87   2/57  Alopecia Body Ventral

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 53
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

  REMOVED  **  CID  1211 **   REASON - Term-Sac
121         121                1134 10/31/88         Ruffled Fur

122         122  672 07/27/87   700 08/24/87   2/36  Emaciated

  REMOVED  **  CID  1221 **   REASON - Moribund
                                702 08/26/87         Emaciated
                                702 08/26/87         Abnormal Posture
                                702 08/26/87         Ruffled Fur

123         123  897 03/08/88   924 04/04/88   2/44  Sore Body (Trunk)  3- 5 Mm

  REMOVED  **  CID  1231 **   REASON - Moribund
                                942 04/22/88         Circling
                                942 04/22/88         Head Tilted
                                942 04/22/88         Abnormal Posture
                                942 04/22/88         Prolapse Penis
                                942 04/22/88         Wound Body (Trunk) 26 or Gr
                                942 04/22/88         Ruffled Fur
                                942 04/22/88         Tachypnea

125         125  868 02/08/88   868 02/08/88   1/42  Swelling Body Ventral

  REMOVED  **  CID  1251 **   REASON - Moribund
                                886 02/26/88         Abnormal Posture
                                886 02/26/88         Tachypnea
                                886 02/26/88         Hypoactivity

126         126  868 02/08/88   868 02/08/88   1/42  Emaciated

  REMOVED  **  CID  1261 **   REASON - Moribund
                                868 02/08/88         Dyspnea
                                868 02/08/88         Abnormal Posture
                                868 02/08/88         Ruffled Fur
                                868 02/08/88         Hypoactivity

129         129  897 03/08/88   897 03/08/88   1/43  Sore Body (Trunk)  3- 5 Mm
                 868 02/08/88   868 02/08/88   1/43  Sore Neck  0- 2 Mm
                 897 03/08/88   897 03/08/88   1/43  Tachypnea
                 897 03/08/88   897 03/08/88   1/43  Ruffled Fur

  REMOVED  **  CID  1291 **   REASON - Moribund

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 54
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
129         129                 900 03/11/88         Tissue Mass Body (Trunk) 21-25 Mm
                                900 03/11/88         Emaciated
                                900 03/11/88         Hyperactive
                                900 03/11/88         Tachypnea

130         130 1108 10/05/88  1122 10/19/88   2/57  Tachypnea
                1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                1079 09/06/88  1122 10/19/88   3/57  Tissue Mass Right Ear  0- 2 Mm

  REMOVED  **  CID  1301 **   REASON - Term-Sac
                               1134 10/31/88         Tissue Mass Right Ear  0- 2 Mm

131         131  616 06/01/87   672 07/27/87   3/37  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID  1311 **   REASON - Dead
                                732 09/25/87         Normal

132         132 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                1108 10/05/88  1122 10/19/88   2/57  Swelling Body Ventral
                1108 10/05/88  1122 10/19/88   2/57  Tachypnea

  REMOVED  **  CID  1321 **   REASON - Dead
                               1134 10/31/88         Normal

134         134  644 06/29/87   728 09/21/87   4/38  Tissue Mass Body (Trunk)  0- 2 Mm
                 728 09/21/87   756 10/19/87   2/38  Emaciated

  REMOVED  **  CID  1341 **   REASON - Dead
                                758 10/21/87         Normal

135         135  756 10/19/87   756 10/19/87   1/38  Alopecia Neck

  REMOVED  **  CID  1351 **   REASON - Dead
                                759 10/22/87         Normal

137         137  700 08/24/87   868 02/08/88   6/48  Tissue Mass Groin  0- 2 Mm
                 728 09/21/87   728 09/21/87   1/48  Tissue Mass Groin  3- 5 Mm
                 952 05/02/88   995 06/14/88   4/48  Sore Body Dorsal  6-10 Mm
                 966 05/16/88   966 05/16/88   1/48  Ruffled Fur
                 966 05/16/88   995 06/14/88   3/48  Tachypnea

  REMOVED  **  CID  1371 **   REASON - Moribund

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 55
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
137         137                1001 06/20/88         Hyperactive
                               1001 06/20/88         Sore Body Dorsal 26 or Gr

138         138  897 03/08/88  1122 10/19/88  10/57  Tachypnea
                1023 07/12/88  1122 10/19/88   8/57  Tissue Mass Left Eye  6-10 Mm
                1094 09/21/88  1094 09/21/88   1/57  Abnormal Posture
                 897 03/08/88  1009 06/28/88   7/57  Tissue Mass Left Eye  3- 5 Mm
                 728 09/21/87   868 02/08/88   6/57  Swelling Left Eye
                 897 03/08/88  1122 10/19/88  10/57  Ruffled Fur

  REMOVED  **  CID  1381 **   REASON - Term-Sac
                               1134 10/31/88         Tissue Mass Left Eye  3- 5 Mm
                               1134 10/31/88         Ruffled Fur
                               1134 10/31/88         Tachypnea

139         139 1023 07/12/88  1023 07/12/88   1/50  Prolapse Penis

  REMOVED  **  CID  1391 **   REASON - Dead
                               1029 07/18/88         Prolapse Penis

144         144  835 01/06/88  1050 08/08/88  12/52  Swelling Body Ventral
                 835 01/06/88  1050 08/08/88  12/52  Tachypnea
                 835 01/06/88   835 01/06/88   1/52  Emaciated
                 756 10/19/87   785 11/17/87   2/52  Tissue Mass Groin  0- 2 Mm
                 835 01/06/88  1050 08/08/88   6/52  Ruffled Fur

  REMOVED  **  CID  1441 **   REASON - Dead
                               1060 08/18/88         Normal

146         146  966 05/16/88   966 05/16/88   1/52  Swelling Body Ventral

  REMOVED  **  CID  1461 **   REASON - Dead
                               1053 08/11/88         Normal

147         147 1009 06/28/88  1009 06/28/88   1/49  Tachypnea
                1009 06/28/88  1009 06/28/88   1/49  Ruffled Fur

  REMOVED  **  CID  1471 **   REASON - Dead
                               1016 07/05/88         Emaciated

149         149  700 08/24/87   700 08/24/87   1/36  Tissue Mass Body Ventral  6-10 Mm

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 56
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

  REMOVED  **  CID  1491 **   REASON - Dead
149         149                 706 08/30/87         Normal

151         151  595 05/11/87  1122 10/19/88  21/57  Alopecia Body Ventral

  REMOVED  **  CID  1511 **   REASON - Term-Sac
                               1134 10/31/88         Normal

152         152  952 05/02/88   952 05/02/88   1/45  Sore Tail  6-10 Mm
                 952 05/02/88   952 05/02/88   1/45  Ruffled Fur
                 868 02/08/88   952 05/02/88   4/45  Swelling Groin
                 785 11/17/87   835 01/06/88   3/45  Tissue Mass Groin  0- 2 Mm
                 952 05/02/88   952 05/02/88   1/45  Tachypnea

  REMOVED  **  CID  1521 **   REASON - Dead
                                962 05/12/88         Normal

154         154  952 05/02/88  1009 06/28/88   5/49  Swelling Body Ventral
                 981 05/31/88   995 06/14/88   2/49  Tachypnea

  REMOVED  **  CID  1541 **   REASON - Moribund
                               1019 07/08/88         Dyspnea
                               1019 07/08/88         Swelling Body Ventral
                               1019 07/08/88         Abnormal Posture

155         155  924 04/04/88  1050 08/08/88   9/52  Ruffled Fur
                 924 04/04/88  1050 08/08/88   9/52  Tachypnea
                1009 06/28/88  1050 08/08/88   4/52  Tissue Mass Right Eye  3- 5 Mm
                 506 02/11/87   616 06/01/87   4/52  Discharge Right Eye
                 595 05/11/87   995 06/14/88  17/52  Swelling Right Eye

  REMOVED  **  CID  1551 **   REASON - Moribund
                               1053 08/11/88         Tissue Mass Right Eye 11-15 Mm
                               1053 08/11/88         Ruffled Fur
                               1053 08/11/88         Tachypnea

156         156 1065 08/23/88  1122 10/19/88   5/57  Swelling Body Ventral
                1065 08/23/88  1122 10/19/88   5/57  Tachypnea
                1094 09/21/88  1122 10/19/88   3/57  Ruffled Fur
                1122 10/19/88  1122 10/19/88   1/57  Abnormal Posture

  REMOVED  **  CID  1561 **   REASON - Moribund

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 57
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
156         156                1124 10/21/88         Dyspnea
                               1124 10/21/88         Abnormal Posture
                               1124 10/21/88         Urine Stain

157         157  595 05/11/87   868 02/08/88  11/42  Alopecia Body Ventral
                  78 12/10/85    78 12/10/85   1/42  Pallor
                 868 02/08/88   868 02/08/88   1/42  Emaciated
                 506 02/11/87   506 02/11/87   1/42  Alopecia Neck

  REMOVED  **  CID  1571 **   REASON - Moribund
                                869 02/09/88         Abnormal Posture
                                869 02/09/88         Ruffled Fur
                                869 02/09/88         Tachypnea
                                869 02/09/88         Hypoactivity

158         158  805 12/07/87   805 12/07/87   1/41  Tissue Mass Tail  3- 5 Mm
                 835 01/06/88   835 01/06/88   1/41  Tissue Mass Tail  6-10 Mm

  REMOVED  **  CID  1581 **   REASON - Dead
                                845 01/16/88         Normal

159         159  168 03/10/86   224 05/05/86   3/40  Alopecia Body Ventral

  REMOVED  **  CID  1591 **   REASON - Dead
                                820 12/22/87         Normal

160         160  868 02/08/88   868 02/08/88   1/43  Sore Body Dorsal  3- 5 Mm
                 897 03/08/88   897 03/08/88   1/43  Swelling Body Ventral
                 897 03/08/88   897 03/08/88   1/43  Sore Body (Trunk)  3- 5 Mm
                 897 03/08/88   897 03/08/88   1/43  Tachypnea

  REMOVED  **  CID  1601 **   REASON - Moribund
                                900 03/11/88         Tissue Mass Body Dorsal 11-15 Mm
                                900 03/11/88         Emaciated
                                900 03/11/88         Ruffled Fur
                                900 03/11/88         Hypoactivity

161         161 1108 10/05/88  1122 10/19/88   2/57  Tachypnea
                1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur

  REMOVED  **  CID  1611 **   REASON - Term-Sac
                               1134 10/31/88         Ruffled Fur

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 58
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
161         161                1134 10/31/88         Tachypnea

162         162 1079 09/06/88  1122 10/19/88   3/57  Swelling Body Ventral
                1122 10/19/88  1122 10/19/88   1/57  Ruffled Fur

  REMOVED  **  CID  1621 **   REASON - Moribund
                               1130 10/27/88         Swelling Body Ventral

163         163  700 08/24/87   700 08/24/87   1/36  Swelling Left Eye

  REMOVED  **  CID  1631 **   REASON - Dead
                                728 09/21/87         Normal

164         164  616 06/01/87   616 06/01/87   1/37  Alopecia Body Ventral

  REMOVED  **  CID  1641 **   REASON - Dead
                                747 10/10/87         Dyspnea
                                747 10/10/87         Hypoactivity

167         167 1122 10/19/88  1122 10/19/88   1/57  Prolapse Penis
                1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                1079 09/06/88  1079 09/06/88   1/57  Swelling Left Eye

  REMOVED  **  CID  1671 **   REASON - Term-Sac
                               1134 10/31/88         Normal

168         168 1079 09/06/88  1094 09/21/88   2/55  Tachypnea
                1079 09/06/88  1079 09/06/88   1/55  Swelling Body Ventral
                1050 08/08/88  1050 08/08/88   1/55  Emaciated
                1079 09/06/88  1094 09/21/88   2/55  Ruffled Fur

  REMOVED  **  CID  1681 **   REASON - Dead
                               1100 09/27/88         Normal

171         171  835 01/06/88   868 02/08/88   2/42  Tissue Mass Groin  0- 2 Mm

  REMOVED  **  CID  1711 **   REASON - Moribund
                                883 02/23/88         Tissue Mass Groin  6-10 Mm
                                883 02/23/88         Emaciated
                                883 02/23/88         Abnormal Posture
                                883 02/23/88         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 59
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

174         174  616 06/01/87   672 07/27/87   3/35  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID  1741 **   REASON - Moribund
                                682 08/06/87         Tissue Mass Left Rear Leg 16-20 Mm

175         175  569 04/15/87   569 04/15/87   1/31  Emaciated

  REMOVED  **  CID  1751 **   REASON - Moribund
                                589 05/05/87         Swelling Body Ventral

176         176 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur

  REMOVED  **  CID  1761 **   REASON - Term-Sac
                               1134 10/31/88         Ruffled Fur

177         177  924 04/04/88   924 04/04/88   1/44  Tachypnea
                 897 03/08/88   924 04/04/88   2/44  Emaciated

  REMOVED  **  CID  1771 **   REASON - Moribund
                                928 04/08/88         Emaciated
                                928 04/08/88         Abnormal Posture
                                928 04/08/88         Ruffled Fur
                                928 04/08/88         Tachypnea
                                928 04/08/88         Hypoactivity

178         178 1065 08/23/88  1122 10/19/88   5/57  Ruffled Fur
                1009 06/28/88  1009 06/28/88   1/57  Discharge Right Eye
                 835 01/06/88  1009 06/28/88   9/57  Swelling Right Eye
                1023 07/12/88  1122 10/19/88   8/57  Tissue Mass Right Eye  6-10 Mm

  REMOVED  **  CID  1781 **   REASON - Term-Sac
                               1134 10/31/88         Tissue Mass Right Eye  6-10 Mm
                               1134 10/31/88         Ruffled Fur

179         179  700 08/24/87   700 08/24/87   1/36  Emaciated

  REMOVED  **  CID  1791 **   REASON - Moribund
                                714 09/07/87         Emaciated
                                714 09/07/87         Abnormal Posture
                                714 09/07/87         Ruffled Fur

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 60
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

180         180  966 05/16/88   966 05/16/88   2/47  Ruffled Fur
                 966 05/16/88   966 05/16/88   2/47  Tachypnea

  REMOVED  **  CID  1801 **   REASON - Dead
                                986 06/05/88         Normal

181         181 1108 10/05/88  1108 10/05/88   1/56  Ruffled Fur
                 168 03/10/86   168 03/10/86   1/56  Alopecia Body Ventral
                1065 08/23/88  1108 10/05/88   4/56  Swelling Body Ventral

  REMOVED  **  CID  1811 **   REASON - Dead
                               1108 10/05/88         Swelling Body Ventral

182         182 1050 08/08/88  1050 08/08/88   1/53  Tachypnea
                 756 10/19/87  1065 08/23/88  16/53  Swelling Right Eye

  REMOVED  **  CID  1821 **   REASON - Moribund
                               1072 08/30/88         Swelling Left Eye
                               1072 08/30/88         Abnormal Posture
                               1072 08/30/88         Prolapse Penis
                               1072 08/30/88         Tachypnea
                               1072 08/30/88         Comatose

183         183  728 09/21/87   728 09/21/87   1/37  Emaciated

  REMOVED  **  CID  1831 **   REASON - Moribund
                                728 09/21/87         Emaciated
                                728 09/21/87         Abnormal Posture
                                728 09/21/87         Tachypnea

184         184 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                 981 05/31/88  1122 10/19/88  10/57  Swelling Body Ventral

  REMOVED  **  CID  1841 **   REASON - Term-Sac
                               1134 10/31/88         Normal

185         185  835 01/06/88   952 05/02/88   5/45  Tissue Mass Tail  3- 5 Mm
                 785 11/17/87   805 12/07/87   2/45  Tissue Mass Tail  0- 2 Mm

  REMOVED  **  CID  1851 **   REASON - Dead
                                959 05/09/88         Tissue Mass Tail 11-15 Mm

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 61
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

187         187  168 03/10/86   168 03/10/86   1/41  Alopecia Body Ventral
                 835 01/06/88   835 01/06/88   1/41  Tissue Mass Left Ear  0- 2 Mm

  REMOVED  **  CID  1871 **   REASON - Dead
                                845 01/16/88         Normal

188         188  196 04/07/86   672 07/27/87  16/36  Alopecia Entire Animal
                 616 06/01/87   700 08/24/87   3/36  Emaciated
                 168 03/10/86   533 03/10/87   2/36  Alopecia Body Ventral
                 168 03/10/86   224 05/05/86   2/36  Alopecia Head
                 224 05/05/86   224 05/05/86   1/36  Alopecia Body (Trunk)

  REMOVED  **  CID  1881 **   REASON - Moribund
                                706 08/30/87         Alopecia Entire Animal
                                706 08/30/87         Emaciated
                                706 08/30/87         Abnormal Posture
                                706 08/30/87         Ruffled Fur

189         189  616 06/01/87   616 06/01/87   1/33  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID  1891 **   REASON - Moribund
                                622 06/07/87         Swelling Body Ventral
                                622 06/07/87         Abnormal Posture
                                622 06/07/87         Hypoactivity

192         192  835 01/06/88   835 01/06/88   1/41  Emaciated
                 835 01/06/88   835 01/06/88   1/41  Hypothermia

  REMOVED  **  CID  1921 **   REASON - Moribund
                                835 01/06/88         Ruffled Fur
                                835 01/06/88         Hypoactivity

193         193  756 10/19/87   897 03/08/88   6/56  Alopecia Neck
                1108 10/05/88  1108 10/05/88   1/56  Tachypnea
                1108 10/05/88  1108 10/05/88   1/56  Swelling Body Ventral
                 450 12/17/86  1094 09/21/88  23/56  Alopecia Body Ventral
                1108 10/05/88  1108 10/05/88   1/56  Ruffled Fur
                1108 10/05/88  1108 10/05/88   1/56  Emaciated

  REMOVED  **  CID  1931 **   REASON - Dead
                               1111 10/08/88         Normal

194         194  168 03/10/86   224 05/05/86   3/32  Alopecia Body Ventral

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 62
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

  REMOVED  **  CID  1941 **   REASON - Dead
194         194                 602 05/18/87         Normal

195         195 1065 08/23/88  1065 08/23/88   1/53  Tachypnea
                1065 08/23/88  1065 08/23/88   1/53  Ruffled Fur
                1065 08/23/88  1065 08/23/88   1/53  Hypoactivity

  REMOVED  **  CID  1951 **   REASON - Moribund
                               1071 08/29/88         Swelling Groin
                               1071 08/29/88         Comatose

196         196 1108 10/05/88  1108 10/05/88   1/55  Emaciated
                1108 10/05/88  1108 10/05/88   1/55  Tachypnea
                1108 10/05/88  1108 10/05/88   1/55  Swelling Body Ventral
                1108 10/05/88  1108 10/05/88   1/55  Ruffled Fur
                1108 10/05/88  1108 10/05/88   1/55  Abnormal Posture

  REMOVED  **  CID  1961 **   REASON - Dead
                               1111 10/08/88         Emaciated

201         201 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                 196 04/07/86   196 04/07/86   1/57  Alopecia Body Ventral
                 805 12/07/87   924 04/04/88   5/57  Swelling Groin

  REMOVED  **  CID  2011 **   REASON - Term-Sac
                               1134 10/31/88         Ruffled Fur

202         202  700 08/24/87   700 08/24/87   1/37  Tissue Mass Body Ventral  3- 5 Mm
                 728 09/21/87   728 09/21/87   1/37  Tissue Mass Body Ventral  6-10 Mm

  REMOVED  **  CID  2021 **   REASON - Moribund
                                733 09/26/87         Dyspnea
                                733 09/26/87         Tissue Mass Body Ventral 26 or Gr
                                733 09/26/87         Hypoactivity

203         203  168 03/10/86   196 04/07/86   2/41  Alopecia Body Ventral

  REMOVED  **  CID  2031 **   REASON - Moribund
                                847 01/18/88         Abnormal Posture
                                847 01/18/88         Ruffled Fur
                                847 01/18/88         Tachypnea
                                847 01/18/88         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 63
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

204         204  616 06/01/87   672 07/27/87   3/37  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID  2041 **   REASON - Dead
                                739 10/02/87         Normal

205         205 1023 07/12/88  1023 07/12/88   1/50  Ruffled Fur
                1023 07/12/88  1023 07/12/88   1/50  Tachypnea

  REMOVED  **  CID  2051 **   REASON - Dead
                               1036 07/25/88         Normal

206         206  785 11/17/87   805 12/07/87   2/48  Tissue Mass Groin  0- 2 Mm

  REMOVED  **  CID  2061 **   REASON - Dead
                                998 06/17/88         Normal

207         207 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                 569 04/15/87   569 04/15/87   1/57  Emaciated

  REMOVED  **  CID  2071 **   REASON - Term-Sac
                               1134 10/31/88         Normal

208         208  364 09/22/86   981 05/31/88  22/47  Alopecia Body Ventral

  REMOVED  **  CID  2081 **   REASON - Moribund
                                985 06/04/88         Tachypnea
                                985 06/04/88         Comatose

210         210 1009 06/28/88  1065 08/23/88   5/53  Swelling Body Ventral
                1023 07/12/88  1065 08/23/88   4/53  Tachypnea

  REMOVED  **  CID  2101 **   REASON - Dead
                               1075 09/02/88         Normal

212         212  569 04/15/87   700 08/24/87   4/38  Emaciated

  REMOVED  **  CID  2121 **   REASON - Moribund
                                780 11/12/87         Alopecia Body Ventral
                                780 11/12/87         Emaciated
                                780 11/12/87         Abnormal Posture

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 64
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

214         214  897 03/08/88   897 03/08/88   1/43  Swelling Body Ventral

  REMOVED  **  CID  2141 **   REASON - Dead
                                910 03/21/88         Normal

216         216  897 03/08/88   952 05/02/88   3/45  Swelling Body Ventral

  REMOVED  **  CID  2161 **   REASON - Dead
                                958 05/08/88         Normal

218         218 1065 08/23/88  1122 10/19/88   5/57  Sore Body Dorsal  6-10 Mm
                1065 08/23/88  1122 10/19/88   5/57  Tachypnea
                1108 10/05/88  1122 10/19/88   2/57  Emaciated
                1108 10/05/88  1122 10/19/88   2/57  Abnormal Posture
                 981 05/31/88  1122 10/19/88  11/57  Swelling Left Eye
                1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur

  REMOVED  **  CID  2181 **   REASON - Dead
                               1134 10/31/88         Swelling Left Eye
                               1134 10/31/88         Emaciated
                               1134 10/31/88         Abnormal Posture
                               1134 10/31/88         Sore Left Rear Leg 11-15 Mm
                               1134 10/31/88         Ruffled Fur

221         221  644 06/29/87   728 09/21/87   4/39  Alopecia Neck
                 785 11/17/87   785 11/17/87   1/39  Tissue Mass Body Ventral 11-15 Mm
                 616 06/01/87   616 06/01/87   1/39  Alopecia Body Ventral

  REMOVED  **  CID  2211 **   REASON - Dead
                                791 11/23/87         Normal

222         222  897 03/08/88   897 03/08/88   1/43  Tachypnea
                 897 03/08/88   897 03/08/88   1/43  Tissue Mass Tail  3- 5 Mm
                 897 03/08/88   897 03/08/88   1/43  Ruffled Fur
                 897 03/08/88   897 03/08/88   1/43  Emaciated

  REMOVED  **  CID  2221 **   REASON - Moribund
                                904 03/15/88         Abnormal Posture
                                904 03/15/88         Tachypnea
                                904 03/15/88         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 65
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

223         223  897 03/08/88   897 03/08/88   1/43  Tachypnea
                 897 03/08/88   897 03/08/88   1/43  Emaciated
                 897 03/08/88   897 03/08/88   1/43  Swelling Body Ventral

  REMOVED  **  CID  2231 **   REASON - Moribund
                                900 03/11/88         Comatose

225         225  569 04/15/87   595 05/11/87   2/32  Swelling Left Eye

  REMOVED  **  CID  2251 **   REASON - Moribund
                                602 05/18/87         Swelling Left Eye
                                602 05/18/87         Emaciated

227         227 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur

  REMOVED  **  CID  2271 **   REASON - Term-Sac
                               1134 10/31/88         Ruffled Fur

229         229 1065 08/23/88  1122 10/19/88   5/57  Tachypnea
                1108 10/05/88  1122 10/19/88   2/57  Swelling Body Ventral
                1065 08/23/88  1122 10/19/88   5/57  Ruffled Fur

  REMOVED  **  CID  2291 **   REASON - Dead
                               1129 10/26/88         Normal

230         230 1094 09/21/88  1094 09/21/88   1/55  Ruffled Fur
                1065 08/23/88  1094 09/21/88   3/55  Tachypnea
                 644 06/29/87  1094 09/21/88  21/55  Alopecia Body Ventral
                 756 10/19/87   756 10/19/87   1/55  Alopecia Neck
                1023 07/12/88  1094 09/21/88   6/55  Swelling Body Ventral

  REMOVED  **  CID  2301 **   REASON - Moribund
                               1103 09/30/88         Tremors
                               1103 09/30/88         Alopecia Body Ventral
                               1103 09/30/88         Swelling Body Ventral
                               1103 09/30/88         Abnormal Posture
                               1103 09/30/88         Ruffled Fur
                               1103 09/30/88         Hypoactivity

231         231  616 06/01/87   616 06/01/87   1/33  Tissue Mass Body (Trunk)  0- 2 Mm
                 450 12/17/86   478 01/14/87   2/33  Alopecia Body Ventral

  REMOVED  **  CID  2311 **   REASON - Moribund

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 66
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
231         231                 622 06/07/87         Emaciated

235         235 1079 09/06/88  1079 09/06/88   1/54  Swelling Body Ventral
                 728 09/21/87   728 09/21/87   1/54  Tissue Mass Groin  6-10 Mm
                 785 11/17/87   805 12/07/87   2/54  Tissue Mass Groin  3- 5 Mm
                 835 01/06/88  1079 09/06/88  14/54  Swelling Right Eye

  REMOVED  **  CID  2351 **   REASON - Dead
                               1089 09/16/88         Swelling Right Eye

236         236  897 03/08/88   897 03/08/88   1/43  Swelling Body Ventral

  REMOVED  **  CID  2361 **   REASON - Moribund
                                918 03/29/88         Tremors
                                918 03/29/88         Abnormal Posture
                                918 03/29/88         Tachypnea
                                918 03/29/88         Hypoactivity

238         238  533 03/10/87   533 03/10/87   1/30  Tissue Mass Body (Trunk)  0- 2 Mm

  REMOVED  **  CID  2381 **   REASON - Moribund
                                555 04/01/87         Swelling Body (Trunk)

242         242 1065 08/23/88  1079 09/06/88   2/54  Tachypnea
                 569 04/15/87   616 06/01/87   3/54  Alopecia Body Ventral
                1009 06/28/88  1079 09/06/88   6/54  Prolapse Penis
                1065 08/23/88  1079 09/06/88   2/54  Ruffled Fur

  REMOVED  **  CID  2421 **   REASON - Moribund
                               1083 09/10/88         Emaciated
                               1083 09/10/88         Prolapse Penis
                               1083 09/10/88         Ruffled Fur
                               1083 09/10/88         Tachypnea

244         244  756 10/19/87   805 12/07/87   3/41  Tissue Mass Groin  3- 5 Mm
                 835 01/06/88   835 01/06/88   1/41  Tissue Mass Groin  0- 2 Mm

  REMOVED  **  CID  2441 **   REASON - Moribund
                                861 02/01/88         Abnormal Posture
                                861 02/01/88         Ruffled Fur
                                861 02/01/88         Tachypnea
                                861 02/01/88         Hypoactivity

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 67
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

245         245  616 06/01/87   835 01/06/88   9/41  Discharge Left Eye
                 506 02/11/87   506 02/11/87   1/41  Swelling Right Eye
                 569 04/15/87   835 01/06/88  11/41  Swelling Left Eye
                 785 11/17/87   835 01/06/88   3/41  Emaciated

  REMOVED  **  CID  2451 **   REASON - Moribund
                                836 01/07/88         Dyspnea
                                836 01/07/88         Tissue Mass Left Eye  3- 5 Mm
                                836 01/07/88         Emaciated
                                836 01/07/88         Abnormal Posture

248         248  835 01/06/88   835 01/06/88   1/41  Emaciated

  REMOVED  **  CID  2481 **   REASON - Moribund
                                844 01/15/88         Abnormal Posture
                                844 01/15/88         Tachypnea
                                844 01/15/88         Hypoactivity

249         249  196 04/07/86   835 01/06/88  16/41  Alopecia Body Ventral
                 785 11/17/87   835 01/06/88   3/41  Tissue Mass Neck  0- 2 Mm

  REMOVED  **  CID  2491 **   REASON - Moribund
                                847 01/18/88         Abnormal Posture
                                847 01/18/88         Tachypnea
                                847 01/18/88         Hypoactivity

251         251  569 04/15/87   868 02/08/88  12/44  Swelling Left Eye
                 897 03/08/88   924 04/04/88   2/44  Tissue Mass Left Eye  6-10 Mm
                 616 06/01/87   924 04/04/88  12/44  Discharge Left Eye

  REMOVED  **  CID  2511 **   REASON - Dead
                                941 04/21/88         Tissue Mass Left Eye  6-10 Mm

254         254  506 02/11/87  1009 06/28/88  21/57  Swelling Right Eye
                1065 08/23/88  1122 10/19/88   5/57  Ruffled Fur
                1050 08/08/88  1050 08/08/88   1/57  Tissue Mass Left Front Leg  6-10 Mm
                 569 04/15/87   616 06/01/87   3/57  Discharge Right Eye
                1023 07/12/88  1122 10/19/88   8/57  Tissue Mass Right Eye  6-10 Mm
                1065 08/23/88  1122 10/19/88   5/57  Tachypnea
                1108 10/05/88  1122 10/19/88   2/57  Abnormal Posture
                1050 08/08/88  1050 08/08/88   1/57  Tissue Mass Groin  6-10 Mm
                 168 03/10/86   168 03/10/86   1/57  Override

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 68
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

  REMOVED  **  CID  2541 **   REASON - Term-Sac
254         254                1134 10/31/88         Tissue Mass Right Eye  6-10 Mm
                               1134 10/31/88         Abnormal Posture
                               1134 10/31/88         Ruffled Fur
                               1134 10/31/88         Tachypnea

255         255  805 12/07/87   805 12/07/87   1/42  Emaciated
                 835 01/06/88   868 02/08/88   2/42  Tachypnea

  REMOVED  **  CID  2551 **   REASON - Moribund
                                882 02/22/88         Abnormal Posture
                                882 02/22/88         Tachypnea
                                882 02/22/88         Hypoactivity

257         257 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur

  REMOVED  **  CID  2571 **   REASON - Term-Sac
                               1134 10/31/88         Ruffled Fur

258         258  897 03/08/88   897 03/08/88   1/43  Tachypnea
                 897 03/08/88   897 03/08/88   1/43  Hyperactive
                 897 03/08/88   897 03/08/88   1/43  Swelling Body Ventral
                 897 03/08/88   897 03/08/88   1/43  Emaciated

  REMOVED  **  CID  2581 **   REASON - Moribund
                                904 03/15/88         Tremors
                                904 03/15/88         Tachypnea
                                904 03/15/88         Hypoactivity

259         259 1108 10/05/88  1122 10/19/88   2/57  Ruffled Fur
                1108 10/05/88  1122 10/19/88   2/57  Swelling Left Eye
                1108 10/05/88  1122 10/19/88   2/57  Tachypnea
                1079 09/06/88  1079 09/06/88   1/57  Swelling Body Ventral

  REMOVED  **  CID  2591 **   REASON - Dead
                               1127 10/24/88         Swelling Left Eye
                               1127 10/24/88         Abnormal Posture
                               1127 10/24/88         Ruffled Fur

260         260  533 03/10/87   533 03/10/87   1/38  Alopecia Body Ventral

  REMOVED  **  CID  2601 **   REASON - Dead

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 69
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
260         260                 758 10/21/87         Normal

261         261  595 05/11/87   595 05/11/87   1/32  Emaciated

  REMOVED  **  CID  2611 **   REASON - Moribund
                                602 05/18/87         Swelling Body Ventral

262         262  981 05/31/88  1009 06/28/88   3/49  Swelling Body Ventral

  REMOVED  **  CID  2621 **   REASON - Dead
                               1020 07/09/88         Normal

263         263  897 03/08/88   924 04/04/88   2/44  Swelling Body Ventral
                 533 03/10/87   533 03/10/87   1/44  Wound Tail Red

  REMOVED  **  CID  2631 **   REASON - Moribund
                                942 04/22/88         Swelling Body Ventral
                                942 04/22/88         Abnormal Posture
                                942 04/22/88         Tachypnea
                                942 04/22/88         Hypoactivity

266         266  835 01/06/88   835 01/06/88   1/41  Emaciated

  REMOVED  **  CID  2661 **   REASON - Moribund
                                844 01/15/88         Abnormal Posture
                                844 01/15/88         Tachypnea
                                844 01/15/88         Hypoactivity

268         268  835 01/06/88   835 01/06/88   1/41  Emaciated
                 506 02/11/87   533 03/10/87   2/41  Swelling Groin
                 395 10/23/86   478 01/14/87   4/41  Alopecia Entire Animal
                 595 05/11/87   616 06/01/87   2/41  Alopecia Body Ventral
                 805 12/07/87   835 01/06/88   2/41  Tissue Mass Groin  3- 5 Mm

  REMOVED  **  CID  2681 **   REASON - Moribund
                                862 02/02/88         Emaciated
                                862 02/02/88         Ruffled Fur
                                862 02/02/88         Tachypnea
                                862 02/02/88         Hypoactivity

271         271  282 07/02/86   282 07/02/86   1/42  Alopecia Body Dorsal

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 70
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
271         271  364 09/22/86   728 09/21/87  14/42  Alopecia Entire Animal
                 450 12/17/86   478 01/14/87   2/42  Malocclusion
                 868 02/08/88   868 02/08/88   1/42  Alopecia Body Ventral

  REMOVED  **  CID  2711 **   REASON - Moribund
                                869 02/09/88         Abnormal Posture
                                869 02/09/88         Hypoactivity

274         274  756 10/19/87   805 12/07/87   3/45  Alopecia Neck
                 196 04/07/86   952 05/02/88   9/45  Alopecia Body Ventral

  REMOVED  **  CID  2741 **   REASON - Moribund
                                961 05/11/88         Emaciated
                                961 05/11/88         Abnormal Posture
                                961 05/11/88         Comatose

275         275  506 02/11/87   506 02/11/87   1/32  Wound Right Ear Red

  REMOVED  **  CID  2751 **   REASON - Moribund
                                597 05/13/87         Dyspnea
                                597 05/13/87         Abnormal Posture

282         282  952 05/02/88   952 05/02/88   1/45  Sore Body (Trunk)  6-10 Mm
                 644 06/29/87   952 05/02/88  12/45  Swelling Left Eye

  REMOVED  **  CID  2821 **   REASON - Moribund
                                965 05/15/88         Tissue Mass Left Eye  6-10 Mm
                                965 05/15/88         Sore Body Dorsal 21-25 Mm
                                965 05/15/88         Ruffled Fur
                                965 05/15/88         Hypoactivity

284         284  805 12/07/87   805 12/07/87   1/40  Swelling Right Eye

  REMOVED  **  CID  2841 **   REASON - Dead
                                824 12/26/87         Swelling Right Eye

287         287  785 11/17/87   785 11/17/87   1/39  Emaciated

  REMOVED  **  CID  2871 **   REASON - Moribund
                                798 11/30/87         Circling
                                798 11/30/87         Dyspnea

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 71
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

289         289  952 05/02/88   952 05/02/88   1/45  Ruffled Fur
                 952 05/02/88   952 05/02/88   1/45  Head Tilted
                 952 05/02/88   952 05/02/88   1/45  Tachypnea
                 952 05/02/88   952 05/02/88   1/45  Emaciated

  REMOVED  **  CID  2891 **   REASON - Moribund
                                952 05/02/88         Comatose

290         290  897 03/08/88   897 03/08/88   1/43  Swelling Body Ventral

  REMOVED  **  CID  2901 **   REASON - Moribund
                                899 03/10/88         Comatose

293         293  952 05/02/88   952 05/02/88   1/46  Swelling Right Eye

  REMOVED  **  CID  2931 **   REASON - Dead
                                981 05/31/88         Swelling Right Eye

294         294  868 02/08/88   868 02/08/88   1/42  Swelling Body Ventral

  REMOVED  **  CID  2941 **   REASON - Moribund
                                884 02/24/88         Emaciated
                                884 02/24/88         Hyperactive
                                884 02/24/88         Tachypnea

295         295  478 01/14/87   478 01/14/87   1/28  Swelling Body Ventral

  REMOVED  **  CID  2951 **   REASON - Moribund
                                494 01/30/87         Swelling Body Ventral
                                494 01/30/87         Emaciated
                                494 01/30/87         Ruffled Fur

296         296  785 11/17/87   785 11/17/87   1/39  Emaciated
                 196 04/07/86   672 07/27/87   9/39  Alopecia Body Ventral
                 700 08/24/87   785 11/17/87   4/39  Alopecia Neck
                 785 11/17/87   785 11/17/87   1/39  Tissue Mass Scrotum  3- 5 Mm

  REMOVED  **  CID  2961 **   REASON - Dead
                                788 11/20/87         Normal

298         298  981 05/31/88   981 05/31/88   1/46  Alopecia Body Ventral
                 835 01/06/88   981 05/31/88   6/46  Swelling Right Eye

NTP  EXP/TEST: 05126-02                                MOUSE AGEING STUDY                                         PAGE: 72
TEST TYPE: CHRONIC-LIFETIME                     CLINICAL OBSERVATIONS BY ANIMAL                                   DATE: 11/06/02
ROUTE: NOT APPLICABLE                                       EISRPT27                                              TIME: 11:16:00
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-B6C3F1                         TRT#: 1                      ROOM/AREA:   5501         FIRST DOSE: 09/24/85
            SEX: MALE                                 TRT: LIFETIME           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
298         298  981 05/31/88   981 05/31/88   1/46  Tachypnea
                 981 05/31/88   981 05/31/88   1/46  Swelling Body Ventral

  REMOVED  **  CID  2981 **   REASON - Moribund
                                981 05/31/88         Tremors
                                981 05/31/88         Swelling Right Eye
                                981 05/31/88         Swelling Body Ventral
                                981 05/31/88         Tachypnea
                                981 05/31/88         Hypoactivity

299         299  981 05/31/88   995 06/14/88   2/47  Sore Right Front Leg  3- 5 Mm
                 981 05/31/88   995 06/14/88   2/47  Tachypnea

  REMOVED  **  CID  2991 **   REASON - Dead
                               1006 06/25/88         Normal

300         300 1009 06/28/88  1023 07/12/88   2/49  Tachypnea
                1009 06/28/88  1023 07/12/88   2/49  Ruffled Fur
                1023 07/12/88  1023 07/12/88   1/49  Abnormal Posture

  REMOVED  **  CID  3001 **   REASON - Dead
                               1025 07/14/88         Emaciated

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                                               ---------- END-OF-REPORT ----------
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