NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 1
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                                                                           TIME: 15:06:38

                                                         EIS REPORT 37

       FACILITY:  BIORELIANCE

       NTP C#:  C98007

       CONTRACT NUMBER:  N01-ES-75408

       CAS NUMBER:  367-51-1

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 2
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 7                      ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: VEHICLE CONTROL    PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 3
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 8                      ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 11.25   MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

71           71   29 01/14/03    85 03/11/03   3/14  Irritation Site Of Application

  REMOVED  **  CID    71 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

72           72   29 01/14/03    85 03/11/03   8/14  Irritation Site Of Application

  REMOVED  **  CID    72 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

73           73   29 01/14/03    93 03/19/03   8/14  Irritation Site Of Application

  REMOVED  **  CID    73 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

74           74   36 01/21/03    64 02/18/03   2/14  Irritation Site Of Application

  REMOVED  **  CID    74 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

75           75   29 01/14/03    93 03/19/03   5/14  Irritation Site Of Application

  REMOVED  **  CID    75 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

76           76   71 02/25/03    78 03/04/03   2/14  Irritation Site Of Application

  REMOVED  **  CID    76 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

77           77   57 02/11/03    93 03/19/03   5/14  Irritation Site Of Application

  REMOVED  **  CID    77 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

78           78   71 02/25/03    93 03/19/03   4/14  Irritation Site Of Application

  REMOVED  **  CID    78 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 4
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 8                      ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 11.25   MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

79           79   64 02/18/03    85 03/11/03   2/14  Irritation Site Of Application

  REMOVED  **  CID    79 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

80           80   29 01/14/03    36 01/21/03   2/14  Irritation Site Of Application

  REMOVED  **  CID    80 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 5
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 9                      ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 22.5    MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

81           81   29 01/14/03    85 03/11/03   5/14  Irritation Site Of Application

  REMOVED  **  CID    81 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

82           82   29 01/14/03    78 03/04/03   6/14  Irritation Site Of Application

  REMOVED  **  CID    82 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

83           83   29 01/14/03    78 03/04/03   7/14  Irritation Site Of Application

  REMOVED  **  CID    83 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

84           84   29 01/14/03    78 03/04/03   6/14  Irritation Site Of Application

  REMOVED  **  CID    84 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

85           85   29 01/14/03    85 03/11/03   5/14  Irritation Site Of Application

  REMOVED  **  CID    85 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

86           86   29 01/14/03    78 03/04/03   6/14  Irritation Site Of Application

  REMOVED  **  CID    86 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

87           87   29 01/14/03    78 03/04/03   6/14  Irritation Site Of Application

  REMOVED  **  CID    87 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

88           88   29 01/14/03    85 03/11/03   6/14  Irritation Site Of Application

  REMOVED  **  CID    88 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 6
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 9                      ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 22.5    MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

89           89   29 01/14/03    93 03/19/03   8/14  Irritation Site Of Application

  REMOVED  **  CID    89 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

90           90   29 01/14/03    85 03/11/03   6/14  Irritation Site Of Application

  REMOVED  **  CID    90 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 7
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 10                     ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 45.0    MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

91           91   85 03/11/03    85 03/11/03   1/14  Thickened Site Of Application
                  22 01/07/03    93 03/19/03   8/14  Irritation Site Of Application

  REMOVED  **  CID    91 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

92           92   22 01/07/03    93 03/19/03   9/14  Irritation Site Of Application

  REMOVED  **  CID    92 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

93           93   85 03/11/03    85 03/11/03   1/14  Thickened Site Of Application
                  22 01/07/03    93 03/19/03   9/14  Irritation Site Of Application

  REMOVED  **  CID    93 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

94           94   22 01/07/03    93 03/19/03  10/14  Irritation Site Of Application
                  64 02/18/03    85 03/11/03   2/14  Thickened Site Of Application

  REMOVED  **  CID    94 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

95           95   29 01/14/03    93 03/19/03  10/14  Irritation Site Of Application

  REMOVED  **  CID    95 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

96           96   22 01/07/03    85 03/11/03   6/14  Irritation Site Of Application

  REMOVED  **  CID    96 **   REASON - TSAC
                                 93 03/19/03         Unremarkable

97           97   22 01/07/03    93 03/19/03   9/14  Irritation Site Of Application

  REMOVED  **  CID    97 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

98           98   22 01/07/03    93 03/19/03  10/14  Irritation Site Of Application

  REMOVED  **  CID    98 **   REASON - TSAC

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 8
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 10                     ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 45.0    MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
98           98                  93 03/19/03         Irritation Site Of Application

99           99   22 01/07/03    93 03/19/03   9/14  Irritation Site Of Application

  REMOVED  **  CID    99 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

100         100   22 01/07/03    93 03/19/03   9/14  Irritation Site Of Application

  REMOVED  **  CID   100 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 9
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 11                     ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 90.0    MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

101         101   22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  50 02/04/03    93 03/19/03   5/14  Thickened Site Of Application
                  57 02/11/03    78 03/04/03   3/14  Ulcer 1

  REMOVED  **  CID   101 **   REASON - TSAC
                                 93 03/19/03         Thickened Site Of Application
                                 93 03/19/03         Irritation Site Of Application

102         102   22 01/07/03    85 03/11/03   4/14  Thickened Site Of Application
                  15 12/31/02    93 03/19/03  12/14  Irritation Site Of Application
                  57 02/11/03    71 02/25/03   2/14  Ulcer 1

  REMOVED  **  CID   102 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

103         103   57 02/11/03    93 03/19/03   2/14  Thickened Site Of Application
                  22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  57 02/11/03    93 03/19/03   3/14  Ulcer 1

  REMOVED  **  CID   103 **   REASON - TSAC
                                 93 03/19/03         Ulcer 1
                                 93 03/19/03         Thickened Site Of Application
                                 93 03/19/03         Irritation Site Of Application

104         104   78 03/04/03    78 03/04/03   1/14  Thickened Site Of Application
                  22 01/07/03    93 03/19/03   9/14  Irritation Site Of Application
                  78 03/04/03    78 03/04/03   1/14  Ulcer 1

  REMOVED  **  CID   104 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

105         105   22 01/07/03    93 03/19/03  10/14  Irritation Site Of Application
                  22 01/07/03    85 03/11/03   8/14  Thickened Site Of Application
                  64 02/18/03    85 03/11/03   4/14  Ulcer 1

  REMOVED  **  CID   105 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

106         106   22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  57 02/11/03    78 03/04/03   4/14  Thickened Site Of Application
                  57 02/11/03    85 03/11/03   4/14  Ulcer 1

  REMOVED  **  CID   106 **   REASON - TSAC

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 10
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 11                     ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 90.0    MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
106         106                  93 03/19/03         Irritation Site Of Application

107         107   29 01/14/03    78 03/04/03   5/14  Thickened Site Of Application
                  22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  78 03/04/03    93 03/19/03   2/14  Ulcer 1

  REMOVED  **  CID   107 **   REASON - TSAC
                                 93 03/19/03         Ulcer 1
                                 93 03/19/03         Irritation Site Of Application

108         108   15 12/31/02    93 03/19/03  12/14  Irritation Site Of Application
                  22 01/07/03    93 03/19/03   7/14  Thickened Site Of Application
                  93 03/19/03    93 03/19/03   1/14  Ulcer 1

  REMOVED  **  CID   108 **   REASON - TSAC
                                 93 03/19/03         Ulcer 1
                                 93 03/19/03         Thickened Site Of Application
                                 93 03/19/03         Irritation Site Of Application

109         109   57 02/11/03    78 03/04/03   2/14  Thickened Site Of Application
                  22 01/07/03    93 03/19/03  10/14  Irritation Site Of Application
                  78 03/04/03    78 03/04/03   1/14  Ulcer 1

  REMOVED  **  CID   109 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

110         110   15 12/31/02    93 03/19/03  12/14  Irritation Site Of Application
                  22 01/07/03    93 03/19/03   6/14  Thickened Site Of Application
                  50 02/04/03    93 03/19/03   4/14  Ulcer 1

  REMOVED  **  CID   110 **   REASON - TSAC
                                 93 03/19/03         Ulcer 1
                                 93 03/19/03         Thickened Site Of Application
                                 93 03/19/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 11
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 12                     ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 180.0   MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

111         111   29 01/14/03    78 03/04/03   7/14  Thickened Site Of Application
                  22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  50 02/04/03    78 03/04/03   3/14  Ulcer 1

  REMOVED  **  CID   111 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

112         112   15 12/31/02    93 03/19/03  12/14  Irritation Site Of Application
                  22 01/07/03    93 03/19/03   7/14  Thickened Site Of Application
                  57 02/11/03    85 03/11/03   5/14  Ulcer 1

  REMOVED  **  CID   112 **   REASON - TSAC
                                 93 03/19/03         Thickened Site Of Application
                                 93 03/19/03         Irritation Site Of Application

113         113   22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  22 01/07/03    78 03/04/03   6/14  Thickened Site Of Application
                  50 02/04/03    85 03/11/03   5/14  Ulcer 1

  REMOVED  **  CID   113 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

114         114   22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  22 01/07/03    78 03/04/03   7/14  Thickened Site Of Application
                  57 02/11/03    85 03/11/03   3/14  Ulcer 1

  REMOVED  **  CID   114 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

115         115   22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  22 01/07/03    93 03/19/03   6/14  Thickened Site Of Application
                  64 02/18/03    93 03/19/03   3/14  Ulcer 1

  REMOVED  **  CID   115 **   REASON - TSAC
                                 93 03/19/03         Ulcer 1
                                 93 03/19/03         Thickened Site Of Application
                                 93 03/19/03         Irritation Site Of Application

116         116   57 02/11/03    93 03/19/03   4/14  Thickened Site Of Application
                  22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  50 02/04/03    93 03/19/03   5/14  Ulcer 1

  REMOVED  **  CID   116 **   REASON - TSAC

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 12
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 12                     ROOM/AREA:     37         FIRST DOSE: 12/17/02
            SEX: FEMALE                               TRT: 180.0   MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
116         116                  93 03/19/03         Ulcer 1
                                 93 03/19/03         Thickened Site Of Application
                                 93 03/19/03         Irritation Site Of Application

117         117   15 12/31/02    93 03/19/03  12/14  Irritation Site Of Application
                  22 01/07/03    85 03/11/03   4/14  Thickened Site Of Application
                  57 02/11/03    93 03/19/03   4/14  Ulcer 1

  REMOVED  **  CID   117 **   REASON - TSAC
                                 93 03/19/03         Ulcer 1
                                 93 03/19/03         Irritation Site Of Application

118         118   22 01/07/03    93 03/19/03   6/14  Thickened Site Of Application
                  15 12/31/02    93 03/19/03  12/14  Irritation Site Of Application
                  64 02/18/03    93 03/19/03   4/14  Ulcer 1

  REMOVED  **  CID   118 **   REASON - TSAC
                                 93 03/19/03         Ulcer 1
                                 93 03/19/03         Thickened Site Of Application
                                 93 03/19/03         Irritation Site Of Application

119         119   22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  22 01/07/03    64 02/18/03   5/14  Thickened Site Of Application
                  22 01/07/03    78 03/04/03   4/14  Ulcer 1

  REMOVED  **  CID   119 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

120         120   22 01/07/03    85 03/11/03   6/14  Thickened Site Of Application
                  22 01/07/03    93 03/19/03  11/14  Irritation Site Of Application
                  50 02/04/03    64 02/18/03   3/14  Ulcer 1

  REMOVED  **  CID   120 **   REASON - TSAC
                                 93 03/19/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 13
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 1                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: VEHICLE CONTROL    PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

2             2   64 02/17/03    64 02/17/03   1/15  Irritation Site Of Application

  REMOVED  **  CID     2 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

3             3   64 02/17/03    64 02/17/03   1/15  Irritation Site Of Application

  REMOVED  **  CID     3 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

5             5   64 02/17/03    64 02/17/03   1/15  Irritation Site Of Application

  REMOVED  **  CID     5 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

10           10   85 03/10/03    85 03/10/03   1/15  Irritation Site Of Application

  REMOVED  **  CID    10 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 14
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 2                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 11.25   MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

11           11   50 02/03/03    71 02/24/03   3/15  Irritation Site Of Application

  REMOVED  **  CID    11 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

12           12   22 01/06/03    71 02/24/03   3/15  Irritation Site Of Application

  REMOVED  **  CID    12 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

13           13   29 01/13/03    93 03/18/03   4/15  Irritation Site Of Application

  REMOVED  **  CID    13 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

14           14   64 02/17/03    64 02/17/03   1/15  Irritation Site Of Application

  REMOVED  **  CID    14 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

15           15   78 03/03/03    78 03/03/03   1/15  Irritation Site Of Application

  REMOVED  **  CID    15 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

16           16   64 02/17/03    85 03/10/03   3/15  Irritation Site Of Application

  REMOVED  **  CID    16 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

17           17   64 02/17/03    85 03/10/03   2/15  Irritation Site Of Application

  REMOVED  **  CID    17 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

18           18   64 02/17/03    85 03/10/03   3/15  Irritation Site Of Application
                  64 02/17/03    64 02/17/03   1/15  Ulcer 1

  REMOVED  **  CID    18 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 15
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 2                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 11.25   MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

19           19   22 01/06/03    85 03/10/03   6/15  Irritation Site Of Application

  REMOVED  **  CID    19 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

20           20   22 01/06/03    93 03/18/03   9/15  Irritation Site Of Application

  REMOVED  **  CID    20 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 16
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 3                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 22.5    MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

21           21   43 01/27/03    93 03/18/03   7/15  Irritation Site Of Application

  REMOVED  **  CID    21 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

22           22   43 01/27/03    93 03/18/03   7/15  Irritation Site Of Application

  REMOVED  **  CID    22 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

23           23   22 01/06/03    93 03/18/03   9/15  Irritation Site Of Application
                  50 02/03/03    50 02/03/03   1/15  Ulcer 1

  REMOVED  **  CID    23 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

24           24   22 01/06/03    93 03/18/03   9/15  Irritation Site Of Application

  REMOVED  **  CID    24 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

25           25   22 01/06/03    85 03/10/03   9/15  Irritation Site Of Application

  REMOVED  **  CID    25 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

26           26   22 01/06/03    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    26 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

27           27   22 01/06/03    93 03/18/03   8/15  Irritation Site Of Application

  REMOVED  **  CID    27 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

28           28   22 01/06/03    93 03/18/03   9/15  Irritation Site Of Application

  REMOVED  **  CID    28 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 17
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 3                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 22.5    MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

29           29   22 01/06/03    93 03/18/03  10/15  Irritation Site Of Application

  REMOVED  **  CID    29 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

30           30   22 01/06/03    93 03/18/03   8/15  Irritation Site Of Application

  REMOVED  **  CID    30 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 18
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 45.0    MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

31           31   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    31 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

32           32   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    32 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

33           33   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    33 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

34           34   15 12/30/02    93 03/18/03  10/15  Irritation Site Of Application

  REMOVED  **  CID    34 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

35           35   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    35 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

36           36   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application

  REMOVED  **  CID    36 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

37           37   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    37 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

38           38   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    38 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 19
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 45.0    MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

39           39   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    39 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

40           40   15 12/30/02    93 03/18/03  10/15  Irritation Site Of Application

  REMOVED  **  CID    40 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 20
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 90.0    MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

41           41   15 12/30/02    78 03/03/03  10/15  Irritation Site Of Application
                  50 02/03/03    50 02/03/03   1/15  Ulcer 1

  REMOVED  **  CID    41 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

42           42   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    42 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

43           43   15 12/30/02    85 03/10/03  10/15  Irritation Site Of Application
                  43 01/27/03    85 03/10/03   2/15  Ulcer 1

  REMOVED  **  CID    43 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

44           44   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application
                  85 03/10/03    85 03/10/03   1/15  Ulcer 1

  REMOVED  **  CID    44 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

45           45   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application

  REMOVED  **  CID    45 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

46           46   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application

  REMOVED  **  CID    46 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

47           47   15 12/30/02    93 03/18/03  11/15  Irritation Site Of Application
                  85 03/10/03    85 03/10/03   1/15  Ulcer 1

  REMOVED  **  CID    47 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

48           48   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application

  REMOVED  **  CID    48 **   REASON - TSAC

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 21
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 90.0    MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
48           48                  93 03/18/03         Irritation Site Of Application

49           49   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application
                  50 02/03/03    85 03/10/03   2/15  Ulcer 1

  REMOVED  **  CID    49 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

50           50   50 02/03/03    57 02/10/03   2/15  Thickened Site Of Application
                  15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application

  REMOVED  **  CID    50 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 22
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 180.0   MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

51           51   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application

  REMOVED  **  CID    51 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

52           52   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application

  REMOVED  **  CID    52 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

53           53   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application
                  50 02/03/03    93 03/18/03   2/15  Ulcer 1

  REMOVED  **  CID    53 **   REASON - TSAC
                                 93 03/18/03         Ulcer 1
                                 93 03/18/03         Irritation Site Of Application

54           54   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application
                  50 02/03/03    93 03/18/03   2/15  Ulcer 1

  REMOVED  **  CID    54 **   REASON - TSAC
                                 93 03/18/03         Ulcer 1
                                 93 03/18/03         Irritation Site Of Application

55           55   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application
                  50 02/03/03    93 03/18/03   2/15  Ulcer 1

  REMOVED  **  CID    55 **   REASON - TSAC
                                 93 03/18/03         Ulcer 1
                                 93 03/18/03         Irritation Site Of Application

56           56   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application
                  93 03/18/03    93 03/18/03   1/15  Ulcer 1

  REMOVED  **  CID    56 **   REASON - TSAC
                                 93 03/18/03         Ulcer 1
                                 93 03/18/03         Irritation Site Of Application

57           57   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application
                  85 03/10/03    85 03/10/03   1/15  Ulcer 1

  REMOVED  **  CID    57 **   REASON - TSAC

NTP  EXP/TEST: 98007-03                               SODIUM THIOGLYCOLATE                                        PAGE: 23
TEST TYPE: SUBCHRON 90-DAY       DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 10/27/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 15:06:38
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:     37         FIRST DOSE: 12/16/02
            SEX: MALE                                 TRT: 180.0   MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS REMOVAL DATA -
57           57                  93 03/18/03         Irritation Site Of Application

58           58   15 12/30/02    85 03/10/03  11/15  Irritation Site Of Application
                  85 03/10/03    85 03/10/03   1/15  Thickened Site Of Application
                  85 03/10/03    85 03/10/03   1/15  Ulcer 1

  REMOVED  **  CID    58 **   REASON - TSAC
                                 93 03/18/03         Unremarkable

59           59   85 03/10/03    85 03/10/03   1/15  Thickened Site Of Application
                  15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application
                  85 03/10/03    85 03/10/03   1/15  Ulcer 1

  REMOVED  **  CID    59 **   REASON - TSAC
                                 93 03/18/03         Irritation Site Of Application

60           60   15 12/30/02    93 03/18/03  12/15  Irritation Site Of Application
                  50 02/03/03    93 03/18/03   2/15  Ulcer 1

  REMOVED  **  CID    60 **   REASON - TSAC
                                 93 03/18/03         Ulcer 1
                                 93 03/18/03         Irritation Site Of Application

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------